<?xml version="1.0" encoding="UTF-8"?>
<uniprot xmlns="https://uniprot.org/uniprot"
 xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"
 xsi:schemaLocation="http://uniprot.org/uniprot http://www.uniprot.org/docs/uniprot.xsd">
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BVK5</accession>
    <name>A0A177BVK5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphoglycerate mutase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_420053</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441564">
        <property type="protein sequence ID" value="OAF98688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029054.1">
        <property type="nucleotide sequence ID" value="XM_018186154.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BVK5"/>
    <dbReference type="GeneID" id="28769640"/>
    <dbReference type="InParanoid" id="A0A177BVK5"/>
    <dbReference type="OrthoDB" id="496981at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050275">
        <property type="entry name" value="PGM_Phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100">
        <property type="entry name" value="BROAD-SPECIFICITY PHOSPHATASE YOR283W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100:SF24">
        <property type="entry name" value="PHOSPHOGLYCERATE MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="218"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAF98688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="256" mass="28832" checksum="946BEA9A970D807F" modified="2016-09-07" version="1">MPPTLLLIRHAQALHNVASDWSIHDPPLSELGKEQCKELQTSLQNNKIGDQVELIVVSSMRRTLQTASIGLEWLIKEKTIEVRPDAGWQENADKPCDTGSPIGTMVQEFPDFDFSTVDPLYPDKTSSLSSNPYAFTRKAILARGQSCLRSLYSRPEKCIAVVSHSGFLRAAVCNRRFFNADWRVFDYDEERMRESQERGEGMDGQGLYLLQEWKETEEKGGGMGRSDVGIFGPETADFPPEVEEEETTEIPTQIAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BVW5</accession>
    <name>A0A177BVW5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1233456</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441563">
        <property type="protein sequence ID" value="OAF99070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029436.1">
        <property type="nucleotide sequence ID" value="XM_018183789.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BVW5"/>
    <dbReference type="GeneID" id="28767275"/>
    <dbReference type="InParanoid" id="A0A177BVW5"/>
    <dbReference type="OrthoDB" id="10437022at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAF99070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="255" mass="28832" checksum="5B7FC6430A557FD8" modified="2016-09-07" version="1">MFYPVEVLLHFPAMVTVGSGQEARRFTEARTNQIIDLQTYERKAAVDEKRWTTSHTKFEAQNPPPAYYHASPMMRLPTEIRLQILAEVLFDPDEITFNFNVPDPSALFLDALKQHAVQLPSTYAKSYSEYSFQALLILRLAPQWKNQIFVELQQNDPGTPRKRSNARKLYTDFHGDSLHRREACLDCYVHCRCWENHSAQCTRNRANGQLLRVCKAIWAPCCTPWGPAGSSSATSTCAASCSTAACCGSTCFRVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BW21</accession>
    <name>A0A177BW21_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription factor Iwr1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_393090</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IWR1/SLC7A6OS family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441562">
        <property type="protein sequence ID" value="OAF99315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029681.1">
        <property type="nucleotide sequence ID" value="XM_018186025.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BW21"/>
    <dbReference type="STRING" id="1460663.A0A177BW21"/>
    <dbReference type="GeneID" id="28769511"/>
    <dbReference type="InParanoid" id="A0A177BW21"/>
    <dbReference type="OrthoDB" id="6255506at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040150">
        <property type="entry name" value="Iwr1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013883">
        <property type="entry name" value="TF_Iwr1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28063">
        <property type="entry name" value="RNA POLYMERASE II NUCLEAR LOCALIZATION PROTEIN IWR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28063:SF1">
        <property type="entry name" value="RNA POLYMERASE II NUCLEAR LOCALIZATION PROTEIN IWR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08574">
        <property type="entry name" value="Iwr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription factor Iwr1" evidence="3">
        <location>
            <begin position="205"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="85"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="162"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="242"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="242"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="272"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="297"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAF99315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="334" mass="37464" checksum="BCDC130736A49E4E" modified="2016-09-07" version="1">MAPQPPQTLSVKRKRNDAPVHHLVVDADRDRTVKRQKSAPRFTWRLLQKPGEHVPAALPSPTPQQNRRFHVSLSAGQRVLVEAPDLPDTVPATAGETPSVPSIADAAEPRDAARATPATPRPRKRPGAAAAVRINPAYAAQSEDDANPSDEHVKHFEKLAEELEQEELAQAKPAPSPVKYLPTGPARRPRKAALAVQDPDAMDIDEYVIDTYVREELMSDSDGNIAEHEGIVGYIILKEEDEDWWNGEDESDKEFDTDEDDENAEDYYANDYPEDELSSDDEFDRDPYQRKYRHGSDDEEYDLNDDAFSGDEDDDHFRRLTLPGQAALLNRPGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BW98</accession>
    <name>A0A177BW98_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CC84DRAFT_1223532</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441564">
        <property type="protein sequence ID" value="OAF98787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029153.1">
        <property type="nucleotide sequence ID" value="XM_018183500.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BW98"/>
    <dbReference type="STRING" id="1460663.A0A177BW98"/>
    <dbReference type="GeneID" id="28766986"/>
    <dbReference type="InParanoid" id="A0A177BW98"/>
    <dbReference type="OrthoDB" id="2496787at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF19">
        <property type="entry name" value="MEMBRANE PROTEIN PTH11-LIKE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G14080)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008057397" description="Rhodopsin domain-containing protein" evidence="8">
        <location>
            <begin position="25"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="101"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="144"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="179"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="230"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="261"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="9">
        <location>
            <begin position="85"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="348"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="411"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="354"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="419"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAF98787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="456" mass="50715" checksum="117A3A39E6A6D821" modified="2016-09-07" version="1">MPVPPLRRVLAFILLASVDIECQCSSRNSTKLLQPCFESACTYDETFATLRAQASVCNRPHDSLSNSIRITAWVSGIAPIIVTAMRFASRHLGGNNFWWDDWVHLASVILVIPMTVFLLLNVEAGIGHHIWDLTYARVVAVGRWTYITTIFWGLEMILLKYSILCLYLRIFPNVWLKRFVFAFMAFTAAFTLPLIGLAAFQCTPIHAIWDLQAQKTAKCIDWIAVLRLTVVYEIIAEIVLFSLPIPIVLKLQMKTAKKIQLMVFFGMGICVIAMAIARVPFLPGVVDTDDQTYTVTPTSILGFAGSGVAHVCAAVPTVKNFTRFCSNGFKQERKFSSTYAKESTLDSSGKRSYKSLQDNKNNATASQTIRSAQQVSRGTSRDTLAHLQLSSIMDAEDGSAVMELHPVLTAAEGGLHPHGGRDREQEKNAWTERIPEQPPKADSASDEAILHNDPYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BX44</accession>
    <name>A0A177BX44_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">FAD/NAD(P)-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CC84DRAFT_1210180</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAD-dependent oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441562">
        <property type="protein sequence ID" value="OAF99261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029627.1">
        <property type="nucleotide sequence ID" value="XM_018182270.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BX44"/>
    <dbReference type="STRING" id="1460663.A0A177BX44"/>
    <dbReference type="GeneID" id="28765756"/>
    <dbReference type="InParanoid" id="A0A177BX44"/>
    <dbReference type="OrthoDB" id="202203at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004174">
        <property type="term" value="F:electron-transferring-flavoprotein dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43735">
        <property type="entry name" value="APOPTOSIS-INDUCING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43735:SF3">
        <property type="entry name" value="FERROPTOSIS SUPPRESSOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00469">
        <property type="entry name" value="PNDRDTASEII"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="361"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="6">
        <location>
            <begin position="6"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAF99261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="420" mass="46199" checksum="2B8435D6AF917A04" modified="2016-09-07" version="1">MVEVRNIVVVGASSSGLQVAHYIAKYLLPVLKNKDRSVKYHLYIINPSSDWFFRIASPRVATSTSLISTEKVFVPLADVFGKYSKDEVTWIQAAATGLNHSARLVEYKRVGEKEEEHLQYHALIVATGSRTYYPAFSTWSDKETTLEALKYTETAAAAAKSIIIAGGGATGVEAAGELGDFLNGRPGWFSTPQRKVAITLLTSAQQLLPTVRKAIGDEAERKLKGLGVDVRYNIRVTDARKEQDGKTTLTLSNGETITTDLYIPAHGVQPNSQWLPPDLLTENKYLNTNARTLRVDLAGPRVYAIGDVSSYSRNTVIDIMDGLPVLVINLKRDLLAYDAKHPERATPGKDRVFKPNTKETMVVPIGTATGVGVLFGFRVPGFLVWLLKGRDYFIGMSMMGTATGSKVNEVKWTKEEEVSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BXC6</accession>
    <name>A0A177BXC6_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Stress-activated map kinase-interacting protein-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CC84DRAFT_1264185</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SIN1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441562">
        <property type="protein sequence ID" value="OAF99167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029533.1">
        <property type="nucleotide sequence ID" value="XM_018185289.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BXC6"/>
    <dbReference type="STRING" id="1460663.A0A177BXC6"/>
    <dbReference type="GeneID" id="28768775"/>
    <dbReference type="InParanoid" id="A0A177BXC6"/>
    <dbReference type="OrthoDB" id="241990at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031932">
        <property type="term" value="C:TORC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005546">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038203">
        <property type="term" value="P:TORC2 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000263">
        <property type="entry name" value="Stress activated MAP kinase interacting protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031567">
        <property type="entry name" value="CRIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008828">
        <property type="entry name" value="Sin1/Avo1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031313">
        <property type="entry name" value="Sin1_PH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13335">
        <property type="entry name" value="TARGET OF RAPAMYCIN COMPLEX 2 SUBUNIT MAPKAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13335:SF1">
        <property type="entry name" value="TARGET OF RAPAMYCIN COMPLEX 2 SUBUNIT MAPKAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16978">
        <property type="entry name" value="CRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16979">
        <property type="entry name" value="SIN1_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRIM" evidence="3">
        <location>
            <begin position="339"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="domain" description="SIN1-type PH" evidence="4">
        <location>
            <begin position="721"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="75"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="506"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="120"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="213"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="228"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="251"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="265"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="302"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="506"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAF99167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="833" mass="91136" checksum="01DCB94217E0966D" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BYS7</accession>
    <name>A0A177BYS7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Serine/threonine-protein kinase ATG1</fullName>
            <ecNumber evidence="4">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Autophagy-related protein 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Serine/threonine-protein kinase atg1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">CC84DRAFT_294399</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23 24">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer. Forms a ternary complex with ATG13 and ATG17.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Preautophagosomal structure membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4"/>
    <dbReference type="EMBL" id="KV441559">
        <property type="protein sequence ID" value="OAG00306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030671.1">
        <property type="nucleotide sequence ID" value="XM_018185770.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BYS7"/>
    <dbReference type="FunCoup" id="A0A177BYS7">
        <property type="interactions" value="73"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177BYS7"/>
    <dbReference type="GeneID" id="28769256"/>
    <dbReference type="InParanoid" id="A0A177BYS7"/>
    <dbReference type="OrthoDB" id="346907at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005776">
        <property type="term" value="C:autophagosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010506">
        <property type="term" value="P:regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042594">
        <property type="term" value="P:response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061709">
        <property type="term" value="P:reticulophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14009">
        <property type="entry name" value="STKc_ATG1_ULK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000817">
        <property type="entry name" value="Serine/threonine-protein kinase ATG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000399">
        <property type="entry name" value="Serine/threonine-protein kinase atg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045269">
        <property type="entry name" value="Atg1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048941">
        <property type="entry name" value="ATG1-like_MIT2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022708">
        <property type="entry name" value="Atg1-like_tMIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24348:SF22">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24348">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE UNC-51-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12063">
        <property type="entry name" value="ATG1-like_MIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21127">
        <property type="entry name" value="ATG1-like_MIT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="13 20" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0072">Autophagy</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12 23" id="KW-0418">Kinase</keyword>
    <keyword evidence="16" id="KW-0472">Membrane</keyword>
    <keyword evidence="11 20" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-0653">Protein transport</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Protein kinase" evidence="22">
        <location>
            <begin position="32"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="346"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="545"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="936"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="21">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="21">
        <location>
            <begin position="364"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="383"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="418"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="21">
        <location>
            <begin position="488"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="21">
        <location>
            <begin position="546"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="562"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="21">
        <location>
            <begin position="936"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="948"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00019599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00030237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="OAG00306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="971" mass="107048" checksum="9FBCA2EDA8E61474" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BYX0</accession>
    <name>A0A177BYX0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">FAD/NAD(P)-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CC84DRAFT_1222737</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441561">
        <property type="protein sequence ID" value="OAF99727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030093.1">
        <property type="nucleotide sequence ID" value="XM_018183408.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BYX0"/>
    <dbReference type="STRING" id="1460663.A0A177BYX0"/>
    <dbReference type="GeneID" id="28766894"/>
    <dbReference type="InParanoid" id="A0A177BYX0"/>
    <dbReference type="OrthoDB" id="417877at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051104">
        <property type="entry name" value="FAD_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46720:SF3">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46720">
        <property type="entry name" value="HYDROXYLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01460)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="5">
        <location>
            <begin position="11"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAF99727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="429" mass="46270" checksum="5A8EC025F0C91773" modified="2016-09-07" version="1">MTVDITAAPLKVAIVGGGPGGLATAIALQKIPSVEVTIYEQASVLREVGAGISIGANSWKVLELLGVADQVNTGHETYTVLNLNGRSGEEVHRREKPHSATGRPPIRTQRTKLQSALLSAVRPGTIKLSKKLVKMEDQGAKGISLTFKDGTSSVVDLVVGADGIRSVVRDTAFPAYPDTLKFTGTTIWRTLLPWSAVSDLDPRFGTTAWWHTPTTHVYFSPVGEGLWEIAARAWHDPAVHSASKVSWGVPVTNEHVESHFTEYLPQIREALARVSAGGWREFAAFAGPEIPTLTAWSNRVVLVGDSSHALSGAFGSGAGFAMEDGWILARALAYYANDTGRALSLFNEIRLPYYARMYEYLASEAARRAKKLADIGDPTFDERVRGKVISDGGGGLDWIYQNDIEAVWKTAVGYGPTDTSNFGPIHASI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BYZ4</accession>
    <name>A0A177BYZ4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_316108</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441559">
        <property type="protein sequence ID" value="OAG00593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030958.1">
        <property type="nucleotide sequence ID" value="XM_018185832.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BYZ4"/>
    <dbReference type="GeneID" id="28769318"/>
    <dbReference type="InParanoid" id="A0A177BYZ4"/>
    <dbReference type="OrthoDB" id="3787430at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG00593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="192" mass="21583" checksum="460C25243D3C02CA" modified="2016-09-07" version="1">MQNNPNVPNGPAPDTATTAEALSMLASLRAHQQCAPPHAHSIFVGATRTEVRSILAPGRLRGTMHYEAMPESMAQDKLGKFLKAIDDDPDRAVLVRSVKLSLECDHFKHSGVAELFNQDVLPYYPFTDDETSEEHPPLTYAPLYLKNIQRRMAHEPRLSQHPTCPTDIALPRKEFFYMYTCLSLYLPSKSMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BZ19</accession>
    <name>A0A177BZ19_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Nucleolar essential protein-like protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CC84DRAFT_1169199</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase NEP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441561">
        <property type="protein sequence ID" value="OAF99676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030042.1">
        <property type="nucleotide sequence ID" value="XM_018179593.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BZ19"/>
    <dbReference type="FunCoup" id="A0A177BZ19">
        <property type="interactions" value="921"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177BZ19"/>
    <dbReference type="GeneID" id="28763079"/>
    <dbReference type="InParanoid" id="A0A177BZ19"/>
    <dbReference type="OrthoDB" id="269804at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005880">
        <property type="term" value="C:nuclear microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070037">
        <property type="term" value="F:rRNA (pseudouridine) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000480">
        <property type="term" value="P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000472">
        <property type="term" value="P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd18088">
        <property type="entry name" value="Nep1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1280.10:FF:000003">
        <property type="entry name" value="Ribosomal RNA small subunit methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005304">
        <property type="entry name" value="Rbsml_bgen_MeTrfase_EMG1/NEP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12636">
        <property type="entry name" value="NEP1/MRA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12636:SF5">
        <property type="entry name" value="RIBOSOMAL RNA SMALL SUBUNIT METHYLTRANSFERASE NEP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03587">
        <property type="entry name" value="EMG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="alpha/beta knot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="8" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="10"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OAF99676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="277" mass="30747" checksum="35C3CB4C6D87314E" modified="2016-09-07" version="1">MGGLPLRNDSPSDRERKAVRDSPERGTKRIRTQSLPPPDLPKLVAEQHQPIPSSDKDTQRLIVVLCSATLETYKASHGVGRGGAGREDKFNLLNSDDHIGVMRKMGRDISEARPDITHQCLLTLLDSPINKAGKLQIYIQTARGVLIEVNPTVRIPRTFKRFAGLMVQLLHRHQIRSTTSNEKLIQVIKNPITDHLPPNCRKVTLSFDSEVVRVRDYIQGLHTDESIAVFIGAMAKGSDDFADQIKDDSIAISQFNLSASVACSKFCHAAEDVWGII</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BZ37</accession>
    <name>A0A177BZ37_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_376907</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441561">
        <property type="protein sequence ID" value="OAF99696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030062.1">
        <property type="nucleotide sequence ID" value="XM_018185968.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BZ37"/>
    <dbReference type="GeneID" id="28769454"/>
    <dbReference type="InParanoid" id="A0A177BZ37"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAF99696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="128" mass="14052" checksum="433F91A71729C216" modified="2016-09-07" version="1">MADSHCNVLPRETPALALSLPLSLCWAGRLLERSTRESGPIHFLVDASQRLTRKKNWTSGALSATVPVGEALQQTLNHLSKFRIRTNFVSVLLPVFAITNALPTILASLAVSHECKLNYQMSTPHPPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BZF8</accession>
    <name>A0A177BZF8_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH CENPB-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1232414</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441561">
        <property type="protein sequence ID" value="OAF99826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030192.1">
        <property type="nucleotide sequence ID" value="XM_018183757.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BZF8"/>
    <dbReference type="GeneID" id="28767243"/>
    <dbReference type="InParanoid" id="A0A177BZF8"/>
    <dbReference type="OrthoDB" id="3942738at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03221">
        <property type="entry name" value="HTH_Tnp_Tc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH CENPB-type" evidence="2">
        <location>
            <begin position="49"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAF99826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="110" mass="12344" checksum="3913DFD0691B420C" modified="2016-09-07" version="1" fragment="single">MDPINEAIEEINSLGPGETFTYTAIAKKYGVVRSTLTRQHKGETASSTTQHANTQKLTPQQELELVSYIEQLTARRLPPTREMVQNFASAIAKEPVSESWVTRFLTRHGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BZH5</accession>
    <name>A0A177BZH5_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">assimilatory sulfite reductase (NADPH)</fullName>
            <ecNumber evidence="4">1.8.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">CC84DRAFT_1168893</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">This enzyme catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>hydrogen sulfide + 3 NADP(+) + 3 H2O = sulfite + 3 NADPH + 4 H(+)</text>
            <dbReference type="Rhea" id="RHEA:13801"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17359"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.8.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sulfur metabolism; hydrogen sulfide biosynthesis; hydrogen sulfide from sulfite (NADPH route): step 1/1.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.2" evidence="4"/>
    <dbReference type="EMBL" id="KV441560">
        <property type="protein sequence ID" value="OAF99991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030357.1">
        <property type="nucleotide sequence ID" value="XM_018179513.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BZH5"/>
    <dbReference type="FunCoup" id="A0A177BZH5">
        <property type="interactions" value="394"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177BZH5"/>
    <dbReference type="GeneID" id="28762999"/>
    <dbReference type="InParanoid" id="A0A177BZH5"/>
    <dbReference type="OrthoDB" id="1856718at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009337">
        <property type="term" value="C:sulfite reductase complex (NADPH)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016903">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004783">
        <property type="term" value="F:sulfite reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000103">
        <property type="term" value="P:sulfate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd06207">
        <property type="entry name" value="CyPoR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.920:FF:000007">
        <property type="entry name" value="Pyruvate:ferredoxin (Flavodoxin) oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.990.10:FF:000010">
        <property type="entry name" value="Sulfite reductase [NADPH] flavoprotein component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000052">
        <property type="entry name" value="Sulfite reductase [NADPH] flavoprotein component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000011">
        <property type="entry name" value="Sulfite reductase flavoprotein component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.990.10">
        <property type="entry name" value="NADPH-cytochrome p450 Reductase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.920.10">
        <property type="entry name" value="Pyruvate-ferredoxin oxidoreductase, PFOR, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003097">
        <property type="entry name" value="CysJ-like_FAD-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023173">
        <property type="entry name" value="NADPH_Cyt_P450_Rdtase_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019752">
        <property type="entry name" value="Pyrv/ketoisovalerate_OxRed_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002869">
        <property type="entry name" value="Pyrv_flavodox_OxRed_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384">
        <property type="entry name" value="NITRIC OXIDE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384:SF109">
        <property type="entry name" value="SULFITE REDUCTASE [NADPH] FLAVOPROTEIN COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00667">
        <property type="entry name" value="FAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01558">
        <property type="entry name" value="POR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53323">
        <property type="entry name" value="Pyruvate-ferredoxin oxidoreductase, PFOR, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="TK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="12" id="KW-0249">Electron transport</keyword>
    <keyword evidence="10" id="KW-0274">FAD</keyword>
    <keyword evidence="7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0288">FMN</keyword>
    <keyword evidence="14" id="KW-0408">Iron</keyword>
    <keyword evidence="15" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0521">NADP</keyword>
    <keyword evidence="13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="19">
        <location>
            <begin position="691"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="21"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00052219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00059320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="OAF99991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="1086" mass="120970" checksum="3979BB05FE1F3A3C" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BZZ6</accession>
    <name>A0A177BZZ6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Zn-dependent exopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CC84DRAFT_362126</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the peptidase M14 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441560">
        <property type="protein sequence ID" value="OAG00172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030537.1">
        <property type="nucleotide sequence ID" value="XM_018185913.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BZZ6"/>
    <dbReference type="STRING" id="1460663.A0A177BZZ6"/>
    <dbReference type="GeneID" id="28769399"/>
    <dbReference type="InParanoid" id="A0A177BZZ6"/>
    <dbReference type="OrthoDB" id="3626597at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06228">
        <property type="entry name" value="M14-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000155">
        <property type="entry name" value="Zn-dependent exopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000834">
        <property type="entry name" value="Peptidase_M14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11705">
        <property type="entry name" value="PROTEASE FAMILY M14 CARBOXYPEPTIDASE A,B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11705:SF143">
        <property type="entry name" value="SLL0236 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00246">
        <property type="entry name" value="Peptidase_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00631">
        <property type="entry name" value="Zn_pept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52035">
        <property type="entry name" value="PEPTIDASE_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008057515" evidence="8">
        <location>
            <begin position="19"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M14" evidence="9">
        <location>
            <begin position="124"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="7">
        <location>
            <position position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS52035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAG00172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="478" mass="51837" checksum="8E07944032EE2BE8" modified="2016-09-07" version="1">MKYSFVASLLASSTVVLGELVPVHFKAPSPAHFRDVVRNDTYDFGCRPVAQPTEDGQFRLAAWLSEPQIVELEKFYERDAEISIKRHLVKRAANAPIGTGDRFSSGTVAPKGLGQQASGTTIASIMNVNEITSALNALKSTYGVNLLTLASKTFEGRTQTVGYVGAGTDKSAYHLYLSAGIHARERGGPDNLIYWISDLLAANKAGTGLTYGQKTYTNAQVKSVLTAGIVFFPLVNPDGVAYDQANGNLWRKNRNTKSGSSGSSVGVDLNRNFDFLWNFKKFFASSESPASTSPSSETFYGTAAASEPETKNHVSVYSNFPKIRWFMDIHSAVGDLLYSWGDDEDQTTTSTMNFQNSAYDGKRGPVGDTAYKEYIPSQDLTNIKNVASKTVAAMKAVGGRSYSSQQAVGLYPTSGATDDYAFSRYWQVSGANKVYGYTLEFAPSGNFYPTLAEFNTNILDTNAGFMDWALAAIAVGLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C0B5</accession>
    <name>A0A177C0B5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative xenobiotic compound monooxygenase, DszA family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CC84DRAFT_1190941</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the NtaA/SnaA/DszA monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441560">
        <property type="protein sequence ID" value="OAG00248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030613.1">
        <property type="nucleotide sequence ID" value="XM_018181154.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C0B5"/>
    <dbReference type="STRING" id="1460663.A0A177C0B5"/>
    <dbReference type="GeneID" id="28764640"/>
    <dbReference type="InParanoid" id="A0A177C0B5"/>
    <dbReference type="OrthoDB" id="5561043at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="entry name" value="Luciferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051260">
        <property type="entry name" value="Diverse_substr_monoxygenases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016215">
        <property type="entry name" value="NTA_MOA"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03860">
        <property type="entry name" value="FMN_nitrolo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30011">
        <property type="entry name" value="ALKANESULFONATE MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30011:SF16">
        <property type="entry name" value="C2H2 FINGER DOMAIN TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000337">
        <property type="entry name" value="NTA_MOA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="Bacterial luciferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0288">FMN</keyword>
    <keyword evidence="4 7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Luciferase-like" evidence="6">
        <location>
            <begin position="41"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00033748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAG00248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="488" mass="53577" checksum="F1F0828C2A65E353" modified="2016-09-07" version="1">MASNAAATNGHDSAKKKLILNAFVEMCSGHQSPGLWQHGTPDDTSTEFNSVSHWVNLAKLLEDAKFHGIFIADVLGGYDVYKGPRNLEPAIKSGAQWPVNEPLAVVPAMAAATKNLGFGVTVATTYEQPYHLARRLSTIDHLTGGRLGWNIVTGYLDSAARNLVNSEQPEHDERYAIAEEYIKVMYKLFESSWRDDAVILDRKRGIYTDPSLVREINHKGKYYTVPGPHICQPSPQRTPLLLQAGTSKAGKTFAAQHAEAIFVAGHSPSVVAKNVAEVRELARSFGRKGEDIKFLALICPVLGRTEEEAKAKFEDYAQYGDLDGALALFGGWTGIDLAVYQDDEELRHVESNAIRSAVEAWSKASPGIPKWTKKTVAKHITVGGLGATVVGTAAQVADEFERWVNEADVDGFNIAYAIKPGTFVDVAELLIPELRNRGLFWDDYKVQGGTYRENFYGRPGESGPLKEHVASGYRWRKDVSAHDAVIPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C0Q0</accession>
    <name>A0A177C0Q0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_363118</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441560">
        <property type="protein sequence ID" value="OAG00190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030555.1">
        <property type="nucleotide sequence ID" value="XM_018185918.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C0Q0"/>
    <dbReference type="GeneID" id="28769404"/>
    <dbReference type="InParanoid" id="A0A177C0Q0"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG00190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="81" mass="9465" checksum="840692FCA01A8C85" modified="2016-09-07" version="1">MTFRRIPANFMTYNTLVPRCVKDWKDTLFIGFLGSIGKGVFVAARSKVLANTPRNRRSDLCRTRESPVKPPPMRKRTWRPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C193</accession>
    <name>A0A177C193_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Adiponectin receptor protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_1129230</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441559">
        <property type="protein sequence ID" value="OAG00487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030852.1">
        <property type="nucleotide sequence ID" value="XM_018175824.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C193"/>
    <dbReference type="FunCoup" id="A0A177C193">
        <property type="interactions" value="17"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177C193"/>
    <dbReference type="GeneID" id="28759310"/>
    <dbReference type="InParanoid" id="A0A177C193"/>
    <dbReference type="OrthoDB" id="5585746at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006882">
        <property type="term" value="P:intracellular zinc ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004254">
        <property type="entry name" value="AdipoR/HlyIII-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855:SF97">
        <property type="entry name" value="ADIPOR-LIKE RECEPTOR IZH3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855">
        <property type="entry name" value="ADIPOR/PROGESTIN RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03006">
        <property type="entry name" value="HlyIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="284"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="314"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="358"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="383"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="411"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="444"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="484"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="337"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="482"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="486"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR604254-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAG00487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="522" mass="58241" checksum="B1EAC1FCFCBB08B1" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C1G8</accession>
    <name>A0A177C1G8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Lipase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CC84DRAFT_1190617</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441559">
        <property type="protein sequence ID" value="OAG00567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030932.1">
        <property type="nucleotide sequence ID" value="XM_018181123.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C1G8"/>
    <dbReference type="FunCoup" id="A0A177C1G8">
        <property type="interactions" value="5"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177C1G8"/>
    <dbReference type="GeneID" id="28764609"/>
    <dbReference type="InParanoid" id="A0A177C1G8"/>
    <dbReference type="OrthoDB" id="438440at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00519">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051299">
        <property type="entry name" value="AB_hydrolase_lip/est"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46640:SF1">
        <property type="entry name" value="FUNGAL LIPASE-LIKE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46640">
        <property type="entry name" value="TRIACYLGLYCEROL LIPASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G06510)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008057614" evidence="4">
        <location>
            <begin position="26"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="domain" description="Fungal lipase-type" evidence="5">
        <location>
            <begin position="121"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="144"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAG00567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="395" mass="43128" checksum="F1180ED361CE139F" modified="2016-09-07" version="1">MGSVSGLLFRVLCLVFVVRSAGALARTTGPAQTPLSTPANDTVSRELFFELEELARIVDISYCVGTAGLGITKPFSCASHCGDEDFKDFELVTAWNTGPLFSDSCGYIALSHPPSRPRILLAFRGTYSIANTIVDLSTIPQEYVPYPGDDDDGATSDFLAPPQPSPSSDGDEPPPADPPECTNCTVHTGFYTSWLHTRKAILPQLTEAINQHPDYEIVLVGHSLGGAVAALAALDLRARGWNPTITTFGEPRVGNAALMSYINARFNITSNRATNRYHRVTHASDPVPLLPLAEWGYTMHSEELFISAPSLPFTQADIRHCNGDEDGSCIAGTEAEGEGWGIPARFKFWELFFAHRDYFWRLGLCVPGGDPKDWYRKYPKHGDDEEGGVQDIGEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C1Q2</accession>
    <name>A0A177C1Q2_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase</fullName>
            <ecNumber evidence="4 13">4.2.1.134</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CC84DRAFT_1154018</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>a very-long-chain (3R)-3-hydroxyacyl-CoA = a very-long-chain (2E)-enoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:45812"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:83728"/>
            <dbReference type="ChEBI" id="CHEBI:85440"/>
            <dbReference type="EC" id="4.2.1.134"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 13">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Endoplasmic reticulum membrane</location>
            <topology evidence="13">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the very long-chain fatty acids dehydratase HACD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.134" evidence="4 13"/>
    <dbReference type="EMBL" id="KV441558">
        <property type="protein sequence ID" value="OAG00762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031127.1">
        <property type="nucleotide sequence ID" value="XM_018176864.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C1Q2"/>
    <dbReference type="FunCoup" id="A0A177C1Q2">
        <property type="interactions" value="550"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177C1Q2"/>
    <dbReference type="GeneID" id="28760350"/>
    <dbReference type="InParanoid" id="A0A177C1Q2"/>
    <dbReference type="OrthoDB" id="46988at2759"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102158">
        <property type="term" value="F:very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030497">
        <property type="term" value="P:fatty acid elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042761">
        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007482">
        <property type="entry name" value="Tyr_Pase-like_PTPLA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11035">
        <property type="entry name" value="VERY-LONG-CHAIN (3R)-3-HYDROXYACYL-COA DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11035:SF24">
        <property type="entry name" value="VERY-LONG-CHAIN (3R)-3-HYDROXYACYL-COA DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04387">
        <property type="entry name" value="PTPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11 13" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="7 13" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5 13" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9 13" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 13" id="KW-0456">Lyase</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="20"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="98"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="144"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="184"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU363109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OAG00762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="217" mass="24779" checksum="10851D402D8F9B27" modified="2016-09-07" version="1">MADDKASVRSDAGQLRIQYLTFYNIVFAALWAAVGITALIFVCLGSSKAEIFREVEPLARWTQTLTLIEIMHAAVGIVKSPVSTTAIQVLTRCIQVWMIWWCFPFSTASSHAFLILVLAWAAADAIRYLYLALNMHGKAPKYLVWLRYTMFYPLYPIGIGAEWWLMYRSVGPVGRVNAALPYMWYFLLALYVPGAYTMFTYMVKQRKKVFGRRAKMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C211</accession>
    <name>A0A177C211_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Eisosome protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1168728</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441559">
        <property type="protein sequence ID" value="OAG00670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031035.1">
        <property type="nucleotide sequence ID" value="XM_018179467.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C211"/>
    <dbReference type="STRING" id="1460663.A0A177C211"/>
    <dbReference type="GeneID" id="28762953"/>
    <dbReference type="InParanoid" id="A0A177C211"/>
    <dbReference type="OrthoDB" id="4070583at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070941">
        <property type="term" value="P:eisosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024527">
        <property type="entry name" value="Eisosome1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28298">
        <property type="entry name" value="EISOSOME PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28298:SF1">
        <property type="entry name" value="EISOSOME PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12757">
        <property type="entry name" value="Eisosome1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="404"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="559"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="559"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="643"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="688"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="719"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="737"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="766"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="819"/>
            <end position="830"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG00670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="871" mass="93770" checksum="98EEBD38446735A5" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C248</accession>
    <name>A0A177C248_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_1262582</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441557">
        <property type="protein sequence ID" value="OAG01526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031891.1">
        <property type="nucleotide sequence ID" value="XM_018185161.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C248"/>
    <dbReference type="GeneID" id="28768647"/>
    <dbReference type="InParanoid" id="A0A177C248"/>
    <dbReference type="OrthoDB" id="3797690at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008057612" evidence="3">
        <location>
            <begin position="23"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="68"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="481"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="82"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="95"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="114"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAG01526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="616" mass="68118" checksum="84DA6EE1ACAF4DC5" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C3D0</accession>
    <name>A0A177C3D0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major facilitator superfamily MFS-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_1100332</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441557">
        <property type="protein sequence ID" value="OAG01671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032036.1">
        <property type="nucleotide sequence ID" value="XM_018174861.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C3D0"/>
    <dbReference type="GeneID" id="28758347"/>
    <dbReference type="InParanoid" id="A0A177C3D0"/>
    <dbReference type="OrthoDB" id="2985014at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718:SF23">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="31"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="61"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="85"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="121"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="191"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="222"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="261"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="296"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="324"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="349"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="396"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="434"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="1"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="459"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAG01671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="501" mass="54061" checksum="4A9A796DCFB48F5F" modified="2016-09-07" version="1">MAVAMSAFLSGSVTVCSTFAGRDLNMSNAEITWMNAATSLSSGSLLLFFGSIADLFGRKTMFIGSMFLFAVICLGAGFSKNGVTLDVLCGILGIFSASAVPSAQGMLGTIYDKPSQRKNKAFGCFSAGNPLGFVFGIIFSGLATQLFSWRAAFWLLAIVYLVISVLAAIFVPSDHAKKVPLNRETLKRLDLPGTFMTILGIGMFCAALTLGGDAPDGWKTSYVLVLLILGALLIVAFIFWEISYPYAMIDMRIWKDRDFSLLLAIISLGFIGFPVATFWLSLWFQRFAGYNALMTGVHMLPMFVCGVLINVIAALIQHKVSNKLLMGIGAFAYVISFTLIAVQRSGNSYWAFSFPGLCLTVVGADFQFVVTNMYVMSSMPPDKQSIAGSLLQTLTRLSQAVGFGIATAIFDAVQQNPSTSGYYANDPIEPYVSTFWFATGMAALGVGLVPFLRIGTQGHHGDKGRLVERNSEDVCDAAPRDEKLSGRTSARDSKEVPVEVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C3M2</accession>
    <name>A0A177C3M2_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF7053 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1189407</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441556">
        <property type="protein sequence ID" value="OAG02075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032440.1">
        <property type="nucleotide sequence ID" value="XM_018181049.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C3M2"/>
    <dbReference type="GeneID" id="28764535"/>
    <dbReference type="InParanoid" id="A0A177C3M2"/>
    <dbReference type="OrthoDB" id="3905686at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055481">
        <property type="entry name" value="DUF7053"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23155">
        <property type="entry name" value="DUF7053"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7053" evidence="1">
        <location>
            <begin position="4"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF23155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG02075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="139" mass="14965" checksum="59A33DBB2A70399E" modified="2016-09-07" version="1">MSSTITTAIPSTIDAATLIATLHNHETMIAALCPGLISYEFISGDKSTEATYSVTDKKPIGQTTYKLTLTNVPDGINSLVNAKPPVGSLTIAAKWRVVGTQLVEEVEIEGNFMVKKMAKGNVEKTHPEQHTKLIELARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C3S1</accession>
    <name>A0A177C3S1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">peptide-methionine (S)-S-oxide reductase</fullName>
            <ecNumber evidence="2">1.8.4.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Peptide-methionine (S)-S-oxide reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_1189440</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-methionyl-[protein] + [thioredoxin]-disulfide + H2O = L-methionyl-(S)-S-oxide-[protein] + [thioredoxin]-dithiol</text>
            <dbReference type="Rhea" id="RHEA:14217"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="Rhea" id="RHEA-COMP:12313"/>
            <dbReference type="Rhea" id="RHEA-COMP:12315"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16044"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:44120"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.8.4.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>[thioredoxin]-disulfide + L-methionine + H2O = L-methionine (S)-S-oxide + [thioredoxin]-dithiol</text>
            <dbReference type="Rhea" id="RHEA:19993"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:58772"/>
            <dbReference type="EC" id="1.8.4.11"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MsrA Met sulfoxide reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.8.4.11" evidence="2"/>
    <dbReference type="EMBL" id="KV441556">
        <property type="protein sequence ID" value="OAG02125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032490.1">
        <property type="nucleotide sequence ID" value="XM_018181055.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C3S1"/>
    <dbReference type="FunCoup" id="A0A177C3S1">
        <property type="interactions" value="560"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177C3S1"/>
    <dbReference type="GeneID" id="28764541"/>
    <dbReference type="InParanoid" id="A0A177C3S1"/>
    <dbReference type="OrthoDB" id="77405at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008113">
        <property type="term" value="F:peptide-methionine (S)-S-oxide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1060.10:FF:000006">
        <property type="entry name" value="Peptide methionine sulfoxide reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1060.10">
        <property type="entry name" value="Peptide methionine sulphoxide reductase MsrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01401">
        <property type="entry name" value="MsrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002569">
        <property type="entry name" value="Met_Sox_Rdtase_MsrA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036509">
        <property type="entry name" value="Met_Sox_Rdtase_MsrA_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00401">
        <property type="entry name" value="msrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43774">
        <property type="entry name" value="PEPTIDE METHIONINE SULFOXIDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43774:SF1">
        <property type="entry name" value="PEPTIDE METHIONINE SULFOXIDE REDUCTASE MSRA 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01625">
        <property type="entry name" value="PMSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55068">
        <property type="entry name" value="Peptide methionine sulfoxide reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptide methionine sulphoxide reductase MsrA" evidence="7">
        <location>
            <begin position="29"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00030643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAG02125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="200" mass="22502" checksum="A346DE3374767D0A" modified="2016-09-07" version="1">MSFLSRFIRPFSMNNAPAAPMAVPQGAQTATLAAGCFWGVEHMYRKAFANKGLLDARVGYIGGDTDSPSYRAVCSGRTGHAEALQVVYDPEQLTYRTILEFFYKMHDPTTVNRQGPDTGSQYRSGVFYHNAEQEKEARDITERVNQQWWKGGVVTEILPAGQWWDAEAYHQLYLDKNPSGYECPSHFLRSFPPLDYSSGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C423</accession>
    <name>A0A177C423_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glucose N-acetyltransferase 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1124185</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG02494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032859.1">
        <property type="nucleotide sequence ID" value="XM_018175676.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C423"/>
    <dbReference type="FunCoup" id="A0A177C423">
        <property type="interactions" value="10"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177C423"/>
    <dbReference type="GeneID" id="28759162"/>
    <dbReference type="InParanoid" id="A0A177C423"/>
    <dbReference type="OrthoDB" id="2014201at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050587">
        <property type="entry name" value="GNT1/Glycosyltrans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11183">
        <property type="entry name" value="GLYCOGENIN SUBFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="27"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="363"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="368"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="381"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG02494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="401" mass="46101" checksum="31E73CDF915DCA4F" modified="2016-09-07" version="1">MRRRRSDELPQFVREVEPRAFRWRRRSWIYIGIFLLACWILYPRRPSYDDSSTTKTKGSKHAYSLYATDSATLCHALLLLDALARYGSKADRVLFYPKHWDLVISDSKDRDSQLLVMARDEYKVKLHPTTLLSVEGRTTDEWTGTWDKSVTKFMAFSLASYERVIALDSDITLLSSLDELFALPPTPIAMPRAYWYETLPQPLTSLLMVIKPDLDEFQRFKQVIYGGGNPALVNAHKFDMELVNDRFEHSAMVLPHRPYALLTGEFRRSNHSAYLGNTFEAWDPEKVFKEAKLVHFSDWPLPKPWIMWPSEGLAEVQPDCGGSHEGTCLERVIWKHLYEDFRQRRKDICRLLSVPAPDWHSIRGAARSNATDGTTHQAPHAKGEADARSDSSTEQGVAHDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C476</accession>
    <name>A0A177C476_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Carnitine acetyl transferas-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CC84DRAFT_211085</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the carnitine/choline acetyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441557">
        <property type="protein sequence ID" value="OAG01682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032047.1">
        <property type="nucleotide sequence ID" value="XM_018185598.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C476"/>
    <dbReference type="FunCoup" id="A0A177C476">
        <property type="interactions" value="443"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177C476"/>
    <dbReference type="GeneID" id="28769084"/>
    <dbReference type="InParanoid" id="A0A177C476"/>
    <dbReference type="OrthoDB" id="240216at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004092">
        <property type="term" value="F:carnitine O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009437">
        <property type="term" value="P:carnitine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.275.20:FF:000003">
        <property type="entry name" value="Carnitine acetyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.10:FF:000019">
        <property type="entry name" value="Carnitine acetyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.10:FF:000025">
        <property type="entry name" value="Carnitine acetyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.70:FF:000003">
        <property type="entry name" value="Carnitine acetyl transferase FacC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.20">
        <property type="entry name" value="Choline/Carnitine o-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.70">
        <property type="entry name" value="Choline/Carnitine o-acyltransferase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000542">
        <property type="entry name" value="Carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042572">
        <property type="entry name" value="Carn_acyl_trans_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039551">
        <property type="entry name" value="Cho/carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042231">
        <property type="entry name" value="Cho/carn_acyl_trans_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589">
        <property type="entry name" value="CARNITINE O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589:SF29">
        <property type="entry name" value="MITOCHONDRIAL CARNITINE O-ACETYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00755">
        <property type="entry name" value="Carn_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00440">
        <property type="entry name" value="ACYLTRANSF_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Choline/carnitine acyltransferase" evidence="9">
        <location>
            <begin position="76"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="28"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="598"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="733"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="28"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="603"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="739"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="751"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="775"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR600542-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAG01682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="831" mass="92017" checksum="0CBCC51EEC1B15F8" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C4K9</accession>
    <name>A0A177C4K9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Class E vacuolar protein-sorting machinery protein HSE1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Class E vacuolar protein-sorting machinery protein hse1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CC84DRAFT_1262358</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the ESCRT-0 complex which is the sorting receptor for ubiquitinated cargo proteins at the multivesicular body (MVB).</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the ESCRT-0 complex composed of HSE1 and VPS27.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endosome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the STAM family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441556">
        <property type="protein sequence ID" value="OAG02435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032800.1">
        <property type="nucleotide sequence ID" value="XM_018185147.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C4K9"/>
    <dbReference type="FunCoup" id="A0A177C4K9">
        <property type="interactions" value="220"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177C4K9"/>
    <dbReference type="GeneID" id="28768633"/>
    <dbReference type="InParanoid" id="A0A177C4K9"/>
    <dbReference type="OrthoDB" id="546434at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00155">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06224">
        <property type="entry name" value="REM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11883">
        <property type="entry name" value="SH3_Sdc25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000072">
        <property type="entry name" value="Unconventional Myosin IB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.840.10">
        <property type="entry name" value="Ras guanine-nucleotide exchange factors catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.870.10">
        <property type="entry name" value="Son of sevenless (SoS) protein Chain: S domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056685">
        <property type="entry name" value="DUF7783"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056686">
        <property type="entry name" value="DUF7784"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008937">
        <property type="entry name" value="Ras-like_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000651">
        <property type="entry name" value="Ras-like_Gua-exchang_fac_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019804">
        <property type="entry name" value="Ras_G-nucl-exch_fac_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023578">
        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001895">
        <property type="entry name" value="RASGEF_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036964">
        <property type="entry name" value="RASGEF_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057827">
        <property type="entry name" value="WW_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113:SF368">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25006">
        <property type="entry name" value="DUF7783"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25008">
        <property type="entry name" value="DUF7784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00617">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00618">
        <property type="entry name" value="RasGEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23518">
        <property type="entry name" value="WW_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00147">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00229">
        <property type="entry name" value="RasGEFN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48366">
        <property type="entry name" value="Ras GEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00720">
        <property type="entry name" value="RASGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50009">
        <property type="entry name" value="RASGEF_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50212">
        <property type="entry name" value="RASGEF_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0967">Endosome</keyword>
    <keyword evidence="8 10" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="13">
        <location>
            <begin position="10"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="N-terminal Ras-GEF" evidence="15">
        <location>
            <begin position="724"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GEF" evidence="14">
        <location>
            <begin position="893"/>
            <end position="1130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="77"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="157"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="630"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="639"/>
            <end position="651"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OAG02435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="1147" mass="128079" checksum="8071B7FCF096C44B" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C4N9</accession>
    <name>A0A177C4N9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1097826</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG02704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033069.1">
        <property type="nucleotide sequence ID" value="XM_018174733.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C4N9"/>
    <dbReference type="STRING" id="1460663.A0A177C4N9"/>
    <dbReference type="GeneID" id="28758219"/>
    <dbReference type="InParanoid" id="A0A177C4N9"/>
    <dbReference type="OrthoDB" id="3363286at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG02704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="392" mass="44673" checksum="F0109F28E149297B" modified="2016-09-07" version="1">MPGRPVPRVRSCLRSPHNAQRRAHATKVLRGDDLGPVVQDEHQTFRLRHDGSKLPLPPVLDPVVVEQRARWKQQKAKPDVAGSTPFQKKLLENPYAHVLASPVRIDRSLSTLLPSALLLTLHIKPHPATLEPWLLPLSLSTPNPPKYLGPPLRFLAHRHNAAHLTARKEVWKKVLGQRFYPFLGPRGMAQLVWRKDMPELLLQMLRARVEDKLAWWFKWRGRLTPVASPSPSDTQDVEDVACVLFYGSLKSRADEIHDEANAIVAEADKWTDYFRTGYGKAFDPHATPPPHLPKATHPPPAWFQPLVPRLAPRAQFPPLDYPTTRWRGRKVAVYSLTDMLGVDRAEALIGRTRYEGERCWVMKRGRQTVDVQMLLGQLQSYLAESGAVWWPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C4P5</accession>
    <name>A0A177C4P5_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">PQ-loop-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CC84DRAFT_1099045</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441556">
        <property type="protein sequence ID" value="OAG02396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032761.1">
        <property type="nucleotide sequence ID" value="XM_018174799.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C4P5"/>
    <dbReference type="GeneID" id="28758285"/>
    <dbReference type="InParanoid" id="A0A177C4P5"/>
    <dbReference type="OrthoDB" id="407617at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006603">
        <property type="entry name" value="PQ-loop_rpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04193">
        <property type="entry name" value="PQ-loop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00679">
        <property type="entry name" value="CTNS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="69"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="104"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="232"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="255"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAG02396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="283" mass="31641" checksum="B2E9FB3AE2104E6D" modified="2016-09-07" version="1" fragment="single">RIWHNWRRKNTDGLPGTMLMLWASCAVPFGVYAIVQASFLALQLQPQCFGGLTLIAWGQTLYYGNKWRAWTATVATVGMMVAFAASEAILILTLRIPYYKGVEWPMMMMAILASVMQCLGLVMPYFELAKRQGRVIGIDFWFLLIDYSGAFFSLMALVAQHTFDALGGSMYIVAMTLETGIVASQAIWLWRVRHIRHEAKKLGMTYDEYVDANPSKKLSRKASLETVADVEAAHPEEPAVPKKCLPRTQEKVSTEEPTNTKTNSAQLHEQTLGAPEKAVTASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C4Q8</accession>
    <name>A0A177C4Q8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1262397</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441556">
        <property type="protein sequence ID" value="OAG02485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032850.1">
        <property type="nucleotide sequence ID" value="XM_018185151.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C4Q8"/>
    <dbReference type="STRING" id="1460663.A0A177C4Q8"/>
    <dbReference type="GeneID" id="28768637"/>
    <dbReference type="InParanoid" id="A0A177C4Q8"/>
    <dbReference type="OrthoDB" id="3923202at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG02485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="151" mass="15541" checksum="C731FB7DC23B305D" modified="2016-09-07" version="1">MAAAAACPVIGSTNDVLPPNHPEVDLTKDGQTCPVVGATTDHHHNLQKHPSVPIPEPKSPLATQCPALKSAVQEPKSQAMDDAICPVVGTATTILPPDHPDTTKAQEGDVCPVTKASVGHHKQKVQPHPSLQAASDVAVCPVTGQHGPAHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C4R9</accession>
    <name>A0A177C4R9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1098617</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441556">
        <property type="protein sequence ID" value="OAG01879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032244.1">
        <property type="nucleotide sequence ID" value="XM_018174778.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C4R9"/>
    <dbReference type="GeneID" id="28758264"/>
    <dbReference type="InParanoid" id="A0A177C4R9"/>
    <dbReference type="OrthoDB" id="5144514at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006771">
        <property type="entry name" value="CetA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36195">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G01990)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04681">
        <property type="entry name" value="Bys1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008057710" evidence="1">
        <location>
            <begin position="20"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG01879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="184" mass="20121" checksum="0C3BB704D8EC6BD6" modified="2016-09-07" version="1">MFFNLCLFLFTAQVALVAALGKLTVANRCSRDMYVWSVDGQGSSRAIKINARSRYTEPIRTSCNGCGVTLKVSRTLQLIGGHHSQFEYAISNNVMYYDISFVDCAKGQDASNCPGHVAGLEIYSPNERKCDRVTCSGNSYCPTKAYYVDQPNQKLGIPEPVYGCGDAGTGADLVFVLCQNQRSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C6M8</accession>
    <name>A0A177C6M8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1166372</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG02529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032894.1">
        <property type="nucleotide sequence ID" value="XM_018178945.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C6M8"/>
    <dbReference type="GeneID" id="28762431"/>
    <dbReference type="InParanoid" id="A0A177C6M8"/>
    <dbReference type="OrthoDB" id="3750348at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="283"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG02529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="356" mass="40759" checksum="E19E788086456AC7" modified="2016-09-07" version="1">MATHFSFLDFPAPVRERIYAHLLAPHPDENETTINYTLKWNWLENPSNTTFGGVPQIDLCRCPREKPRTTNIKTKDHMYTRYKCHGPEVKFASGWEDLWVPSQAYANSGQINFLRPATQEELSRRPSGNILSTNKTIYEEALPVLYRGRNFLFVTGPCPRGRYQAYATQRFFAGLSLFARVHITGFSLNILPHEEDCQTEDITKAYRDLAEWVQHNLPLFQVLGLNLWHPRLTSMAKVFECLLQRNGVKIELDRGQNDGWVEEVEDVEGFRAYLSAGSRQLDHVDEAPPQGEASMDVIPGEERRLNVSRPPRRSTGKVSDWESFDNNTNEDEEWSDTLLSPASSREGGVVDGWEVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C781</accession>
    <name>A0A177C781_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BOD1/SHG1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_939179</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG02981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033346.1">
        <property type="nucleotide sequence ID" value="XM_018187929.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C781"/>
    <dbReference type="STRING" id="1460663.A0A177C781"/>
    <dbReference type="GeneID" id="28771415"/>
    <dbReference type="InParanoid" id="A0A177C781"/>
    <dbReference type="OrthoDB" id="5579731at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055264">
        <property type="entry name" value="BOD1/SHG1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28034:SF1">
        <property type="entry name" value="NUCLEOMORPHIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28034">
        <property type="entry name" value="SET1 COMPLEX COMPONENT SHG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05205">
        <property type="entry name" value="COMPASS-Shg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BOD1/SHG1" evidence="2">
        <location>
            <begin position="39"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="262"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="366"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="262"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="300"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="310"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="336"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="435"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="452"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="480"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="552"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="585"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="600"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="680"/>
            <end position="700"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG02981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="700" mass="84116" checksum="4D7B6F1B3FDD20FB" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C7E8</accession>
    <name>A0A177C7E8_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">WSC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CC84DRAFT_1219656</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG02698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033063.1">
        <property type="nucleotide sequence ID" value="XM_018183095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C7E8"/>
    <dbReference type="STRING" id="1460663.A0A177C7E8"/>
    <dbReference type="GeneID" id="28766581"/>
    <dbReference type="InParanoid" id="A0A177C7E8"/>
    <dbReference type="OrthoDB" id="2019572at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051694">
        <property type="entry name" value="Immunoregulatory_rcpt-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002889">
        <property type="entry name" value="WSC_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549">
        <property type="entry name" value="PAIRED IMMUNOGLOBULIN-LIKE TYPE 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01822">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00321">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51212">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008057910" description="WSC domain-containing protein" evidence="7">
        <location>
            <begin position="21"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="186"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="8">
        <location>
            <begin position="44"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="147"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="147"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAG02698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="279" mass="29049" checksum="6578534AD5A941C8" modified="2016-09-07" version="1">MFSIRLAALAAAALFSMASADDSSSSSSKIVSIPTPTATVAVSAMSTLGCFATGVPLEDHGKGKFVTAGSCQQICVQLDKNVLGLSDGERCWCGDKFPPRDTKIDDKKCTSMCSGDDTTVCGGAGLLWVMTTGNTRNVIEYADPIVESSSSPSASKTASPTSSSAPESAAASSATSEPEKKGASTAGIAAGVVVGVVVLAAIIGGVFFYLRRQKRQAVEEEYRRQAAVNSFVSGGKLHTSNSSMTDSRLDPEFMARRQSNGSIADNEDYSRRILKVTNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2023-06-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C7L8</accession>
    <name>A0A177C7L8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_861659</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG03643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034008.1">
        <property type="nucleotide sequence ID" value="XM_018187672.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C7L8"/>
    <dbReference type="GeneID" id="28771158"/>
    <dbReference type="InParanoid" id="A0A177C7L8"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG03643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="111" mass="13137" checksum="CF6137796BCF3CC5" modified="2016-09-07" version="1">MRRTRTAASNRLLLLDWCFAQGIDRHPRKRTFRCCIFVPPSQLPLPSYGQRSGRQSRLIYQKYIMYRSSARTFTPILLHRSRLHVEHSRLLSSFVRRPCIRNPCDLVSHLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C7V6</accession>
    <name>A0A177C7V6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cytochrome b5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CC84DRAFT_1197236</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4 5">Belongs to the cytochrome b5 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG03486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033851.1">
        <property type="nucleotide sequence ID" value="XM_018181510.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C7V6"/>
    <dbReference type="STRING" id="1460663.A0A177C7V6"/>
    <dbReference type="GeneID" id="28764996"/>
    <dbReference type="InParanoid" id="A0A177C7V6"/>
    <dbReference type="OrthoDB" id="260519at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050668">
        <property type="entry name" value="Cytochrome_b5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19359">
        <property type="entry name" value="CYTOCHROME B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19359:SF14">
        <property type="entry name" value="CYTOCHROME B5 A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00363">
        <property type="entry name" value="CYTOCHROMEB5"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0349">Heme</keyword>
    <keyword evidence="3 5" id="KW-0408">Iron</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="6">
        <location>
            <begin position="2"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAG03486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="84" mass="9384" checksum="C57488995CEC484F" modified="2016-09-07" version="1">MSESFTAKQVAEHKDVDKGLYIIIDGGVYALESFVDEHPGGAKILKRVGGKDASKQFWKYHNESVLKKYGEKLKVGTLKEEAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2023-06-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C846</accession>
    <name>A0A177C846_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1166713</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG02927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033292.1">
        <property type="nucleotide sequence ID" value="XM_018179033.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C846"/>
    <dbReference type="GeneID" id="28762519"/>
    <dbReference type="InParanoid" id="A0A177C846"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG02927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="58" mass="6214" checksum="121B45DD78651CB3" modified="2016-09-07" version="1">MRQLNSISIRLRIDRLPSKGVVLSAPYIWAGTGATCLASSVSGGCNTRKSRLGHLCLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C8M4</accession>
    <name>A0A177C8M4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">WSC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_841092</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG03481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033846.1">
        <property type="nucleotide sequence ID" value="XM_018187621.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C8M4"/>
    <dbReference type="GeneID" id="28771107"/>
    <dbReference type="InParanoid" id="A0A177C8M4"/>
    <dbReference type="OrthoDB" id="5985073at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002889">
        <property type="entry name" value="WSC_carb-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01822">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51212">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="229"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="267"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="3">
        <location>
            <begin position="77"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAG03481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="319" mass="35589" checksum="35C4D6150D199534" modified="2016-09-07" version="1">MPSATSVIGEILNHMSPTTVKVETATKTIAAMAPEAPAASMHASVATDFSASFTGDVTANYEEAGWANITILDDAGFWYNQGCFVSESSNKSAMGDILHVSSKLVRWSDKMDVRLCRQHCAYYAPDEGHEYFGIANGQECYCGNFISNHARRVDQSNCHLWCPPREDRGDDKFLCGGKGSMIVYGRRKWNMALQTSEDSEPGYRPPRPHIQSSPARRNEWRDHVGLSHLLYWMSPGSIIAFFIQWWWSCGHPFCWVWSASLKGFLGSWVIAGIIGMLSMVFYWGCVSATRPPDLILQRAAFAERAHRIGAPIPGPDFIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C942</accession>
    <name>A0A177C942_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Tricorn protease domain 2-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CC84DRAFT_1165851</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat AIP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG03641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034006.1">
        <property type="nucleotide sequence ID" value="XM_018178810.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C942"/>
    <dbReference type="FunCoup" id="A0A177C942">
        <property type="interactions" value="749"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177C942"/>
    <dbReference type="GeneID" id="28762296"/>
    <dbReference type="InParanoid" id="A0A177C942"/>
    <dbReference type="OrthoDB" id="2306at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005884">
        <property type="term" value="C:actin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003786">
        <property type="term" value="F:actin lateral binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030042">
        <property type="term" value="P:actin filament depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051014">
        <property type="term" value="P:actin filament severing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051016">
        <property type="term" value="P:barbed-end actin filament capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032466">
        <property type="term" value="P:negative regulation of cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000102">
        <property type="entry name" value="Actin-interacting protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000167">
        <property type="entry name" value="Actin-interacting protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19856:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19856">
        <property type="entry name" value="WD-REPEATCONTAINING PROTEIN WDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50960">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63825">
        <property type="entry name" value="YWTD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="54"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="185"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="229"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="322"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="530"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="573"/>
            <end position="607"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAG03641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="607" mass="64064" checksum="C7585909E5BEDDBC" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C9S2</accession>
    <name>A0A177C9S2_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RlpA-like protein double-psi beta-barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_1166240</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG04136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034501.1">
        <property type="nucleotide sequence ID" value="XM_018178907.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C9S2"/>
    <dbReference type="STRING" id="1460663.A0A177C9S2"/>
    <dbReference type="GeneID" id="28762393"/>
    <dbReference type="InParanoid" id="A0A177C9S2"/>
    <dbReference type="OrthoDB" id="623670at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22191">
        <property type="entry name" value="DPBB_RlpA_EXP_N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="entry name" value="RlpA-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051477">
        <property type="entry name" value="Expansin_CellWall"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836:SF27">
        <property type="entry name" value="RLPA-LIKE PROTEIN DOUBLE-PSI BETA-BARREL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50685">
        <property type="entry name" value="Barwin-like endoglucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="73"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAG04136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="219" mass="23879" checksum="366A56A5A5A72324" modified="2016-09-07" version="1" fragment="single">MATGAEEVKVPEPVHGAQGSSFNAPDWELPEEGTATRKRLHLGSASTRWAIADRFDRVLPPYKRYVGLKRRTFLLVLLGALLAVIALAVGLGVGLGNKHKDQNLPLPSNSQTFTGDLTYYNPALGACGIESNDDSPIVAVSHFTFDAVQIGSDPNQNPLCGKKIRARRRREDGKTVSVDLTVVDRCTGCQPTDIDVSPTMFDRLADHDLGRVDVTWAWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CB23</accession>
    <name>A0A177CB23_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Sugar transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CC84DRAFT_1218284</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG04873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035238.1">
        <property type="nucleotide sequence ID" value="XM_018182983.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CB23"/>
    <dbReference type="FunCoup" id="A0A177CB23">
        <property type="interactions" value="46"/>
    </dbReference>
    <dbReference type="GeneID" id="28766469"/>
    <dbReference type="InParanoid" id="A0A177CB23"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000023">
        <property type="term" value="P:maltose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000254">
        <property type="entry name" value="MAL31p Maltose permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF5">
        <property type="entry name" value="ALPHA-GLUCOSIDES PERMEASE MPH2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0462">Maltose metabolism</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="160"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="185"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="219"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="254"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="342"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="377"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="404"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="432"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="480"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="503"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="11">
        <location>
            <begin position="84"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00026248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OAG04873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="576" mass="64205" checksum="17033666625FE603" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CBP3</accession>
    <name>A0A177CBP3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Glucoamylase</fullName>
            <ecNumber evidence="9">3.2.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">1,4-alpha-D-glucan glucohydrolase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Glucan 1,4-alpha-glucosidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CC84DRAFT_1093034</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>Hydrolysis of terminal (1-&gt;4)-linked alpha-D-glucose residues successively from non-reducing ends of the chains with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the glycosyl hydrolase 15 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.3" evidence="9"/>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG04611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034976.1">
        <property type="nucleotide sequence ID" value="XM_018174499.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CBP3"/>
    <dbReference type="STRING" id="1460663.A0A177CBP3"/>
    <dbReference type="GeneID" id="28757985"/>
    <dbReference type="InParanoid" id="A0A177CBP3"/>
    <dbReference type="OrthoDB" id="6123450at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004339">
        <property type="term" value="F:glucan 1,4-alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001070">
        <property type="term" value="F:starch binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.10:FF:000018">
        <property type="entry name" value="Glucoamylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013784">
        <property type="entry name" value="Carb-bd-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002044">
        <property type="entry name" value="CBM20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011613">
        <property type="entry name" value="GH15-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000165">
        <property type="entry name" value="Glucoamylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046966">
        <property type="entry name" value="Glucoamylase_active_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008291">
        <property type="entry name" value="Glucoamylase_SBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31616:SF12">
        <property type="entry name" value="GLUCOAMYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31616">
        <property type="entry name" value="TREHALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00686">
        <property type="entry name" value="CBM_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00723">
        <property type="entry name" value="Glyco_hydro_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001031">
        <property type="entry name" value="Glu-a-glcsd_SBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00736">
        <property type="entry name" value="GLHYDRLASE15"/>
    </dbReference>
    <dbReference type="SMART" id="SM01065">
        <property type="entry name" value="CBM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49452">
        <property type="entry name" value="Starch-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51166">
        <property type="entry name" value="CBM20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00820">
        <property type="entry name" value="GLUCOAMYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 9 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 9" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 13" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008057976" description="Glucoamylase" evidence="13">
        <location>
            <begin position="21"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="domain" description="CBM20" evidence="14">
        <location>
            <begin position="511"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="601"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="206"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10">
        <location>
            <position position="209"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR001031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001031-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR001031-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OAG04611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="627" mass="68159" checksum="A7ECF0557DCCE19C" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CC06</accession>
    <name>A0A177CC06_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PEBP-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1093359</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG04731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035096.1">
        <property type="nucleotide sequence ID" value="XM_018174509.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CC06"/>
    <dbReference type="STRING" id="1460663.A0A177CC06"/>
    <dbReference type="GeneID" id="28757995"/>
    <dbReference type="InParanoid" id="A0A177CC06"/>
    <dbReference type="OrthoDB" id="2506647at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030414">
        <property type="term" value="F:peptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030162">
        <property type="term" value="P:regulation of proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046578">
        <property type="term" value="P:regulation of Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00866">
        <property type="entry name" value="PEBP_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.280.10">
        <property type="entry name" value="PEBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008914">
        <property type="entry name" value="PEBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036610">
        <property type="entry name" value="PEBP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035810">
        <property type="entry name" value="PEBP_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11362">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11362:SF141">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01161">
        <property type="entry name" value="PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49777">
        <property type="entry name" value="PEBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008057963" evidence="2">
        <location>
            <begin position="19"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG04731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="232" mass="23424" checksum="F64479B4B3A61CBB" modified="2016-09-07" version="1">MHFSKGLVVAAAVGIAQAQTPKGFTPAAKAQLDVIFNSTKVSTPGELLSKAATASQPQLALPSSAVSSNETYVFVMLDLDVPAASGNSSRRVLLHAMNTGFKATKQSIAGGNVLLASSEKGPATYIGPSPPASDTIAHRYTQLLFKQPSTLKASASDFSNTQARIGFDIAGFAKQNGLGEPVAGNFFMVDGRASGAAAATGTRGAGGARQTGGGGGRGNGTSPRKLSPVVCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CDX5</accession>
    <name>A0A177CDX5_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Urease</fullName>
            <ecNumber evidence="2 9">3.5.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7 9">Urea amidohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CC84DRAFT_1244418</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>urea + 2 H2O + H(+) = hydrogencarbonate + 2 NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:20557"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16199"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.1.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Ni cation</name>
            <dbReference type="ChEBI" id="CHEBI:25516"/>
        </cofactor>
        <text evidence="11">Binds 2 nickel ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Nitrogen metabolism; urea degradation; CO(2) and NH(3) from urea (urease route): step 1/1.</text>
    </comment>
    <comment type="PTM">
        <text evidence="10">Carbamylation allows a single lysine to coordinate two nickel ions.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.5" evidence="2 9"/>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG05834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036199.1">
        <property type="nucleotide sequence ID" value="XM_018184153.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CDX5"/>
    <dbReference type="STRING" id="1460663.A0A177CDX5"/>
    <dbReference type="GeneID" id="28767639"/>
    <dbReference type="InParanoid" id="A0A177CDX5"/>
    <dbReference type="OrthoDB" id="1708534at2759"/>
    <dbReference type="UniPathway" id="UPA00258">
        <property type="reaction ID" value="UER00370"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035550">
        <property type="term" value="C:urease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009039">
        <property type="term" value="F:urease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043419">
        <property type="term" value="P:urea catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00375">
        <property type="entry name" value="Urease_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00407">
        <property type="entry name" value="Urease_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00390">
        <property type="entry name" value="Urease_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.280.10:FF:000001">
        <property type="entry name" value="Urease subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.150.10">
        <property type="entry name" value="Urease, beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.280.10">
        <property type="entry name" value="Urease, gamma-like subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01953">
        <property type="entry name" value="Urease_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008221">
        <property type="entry name" value="Urease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011612">
        <property type="entry name" value="Urease_alpha_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050112">
        <property type="entry name" value="Urease_alpha_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017950">
        <property type="entry name" value="Urease_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005848">
        <property type="entry name" value="Urease_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017951">
        <property type="entry name" value="Urease_asu_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002019">
        <property type="entry name" value="Urease_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036461">
        <property type="entry name" value="Urease_betasu_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002026">
        <property type="entry name" value="Urease_gamma/gamma-beta_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036463">
        <property type="entry name" value="Urease_gamma_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029754">
        <property type="entry name" value="Urease_Ni-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009671">
        <property type="entry name" value="PRK13192.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009686">
        <property type="entry name" value="PRK13207.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01792">
        <property type="entry name" value="urease_alph"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00192">
        <property type="entry name" value="urease_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00193">
        <property type="entry name" value="urease_gam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43440">
        <property type="entry name" value="UREASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43440:SF1">
        <property type="entry name" value="UREASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00449">
        <property type="entry name" value="Urease_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00699">
        <property type="entry name" value="Urease_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00547">
        <property type="entry name" value="Urease_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001222">
        <property type="entry name" value="Urease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01752">
        <property type="entry name" value="UREASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51278">
        <property type="entry name" value="Urease, beta-subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54111">
        <property type="entry name" value="Urease, gamma-subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01120">
        <property type="entry name" value="UREASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00145">
        <property type="entry name" value="UREASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51368">
        <property type="entry name" value="UREASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 9 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 9 11" id="KW-0533">Nickel</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Urease" evidence="14">
        <location>
            <begin position="401"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="12 13">
        <location>
            <position position="592"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="406"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="408"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="via carbamate group" evidence="11">
        <location>
            <position position="489"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" description="via carbamate group" evidence="11">
        <location>
            <position position="489"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="491"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="518"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="544"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="632"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-carboxylysine" evidence="10">
        <location>
            <position position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR001222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001222-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR001222-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR611612-52"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OAG05834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="837" mass="90396" checksum="4AB8D3282D47EF7A" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CF93</accession>
    <name>A0A177CF93_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1244885</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG06006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036371.1">
        <property type="nucleotide sequence ID" value="XM_018184170.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CF93"/>
    <dbReference type="GeneID" id="28767656"/>
    <dbReference type="InParanoid" id="A0A177CF93"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG06006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="162" mass="18097" checksum="A3E2FD8CDFAF1055" modified="2016-09-07" version="1">MDAASHLKIIFRLMSPLRSTAEPPKSASQGTDSAGKTYVPCRDASKTGNGELTSSNTLGSKRSAFCNSVFWKPRSSLRCTSMKDASRSRRWRLTSSIRSCWSSARLRDENSAKIRRGDEAMAGPCFVMRQIRSYRSIIQPFGMAMMIMIRMTSKAKMSRGTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CFU1</accession>
    <name>A0A177CFU1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">2'-phosphotransferase</fullName>
            <ecNumber evidence="3">2.7.1.160</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_1196490</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the last step of tRNA splicing, the transfer of the splice junction 2'-phosphate from ligated tRNA to NAD to produce ADP-ribose 1''-2'' cyclic phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>2'-phospho-[ligated tRNA] + NAD(+) = mature tRNA + ADP-alpha-D-ribose 1'',2''-cyclic phosphate + nicotinamide</text>
            <dbReference type="Rhea" id="RHEA:23324"/>
            <dbReference type="Rhea" id="RHEA-COMP:11106"/>
            <dbReference type="Rhea" id="RHEA-COMP:11107"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:76596"/>
            <dbReference type="ChEBI" id="CHEBI:82883"/>
            <dbReference type="ChEBI" id="CHEBI:85027"/>
            <dbReference type="EC" id="2.7.1.160"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the KptA/TPT1 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.160" evidence="3"/>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG06473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036838.1">
        <property type="nucleotide sequence ID" value="XM_018181466.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CFU1"/>
    <dbReference type="FunCoup" id="A0A177CFU1">
        <property type="interactions" value="229"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CFU1"/>
    <dbReference type="GeneID" id="28764952"/>
    <dbReference type="InParanoid" id="A0A177CFU1"/>
    <dbReference type="OrthoDB" id="419694at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000215">
        <property type="term" value="F:tRNA 2'-phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006388">
        <property type="term" value="P:tRNA splicing, via endonucleolytic cleavage and ligation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.170.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.970">
        <property type="entry name" value="RNA 2'-phosphotransferase, Tpt1/KptA family, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002745">
        <property type="entry name" value="Ptrans_KptA/Tpt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042081">
        <property type="entry name" value="RNA_2'-PTrans_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042080">
        <property type="entry name" value="RNA_2'-PTrans_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12684">
        <property type="entry name" value="PUTATIVE PHOSPHOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12684:SF2">
        <property type="entry name" value="TRNA 2'-PHOSPHOTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01885">
        <property type="entry name" value="PTS_2-RNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56399">
        <property type="entry name" value="ADP-ribosylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="87"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="279"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="286"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="300"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAG06473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="325" mass="34729" checksum="0426A2A788B22E12" modified="2016-09-07" version="1">MARGGGRNPAFLPREQQVSRKVSWLLRHGAHSEGLQLGKGGYVGVDAALRTRCLTALKVTFPELRDVVRTNDKQRFSMVLRERLEGAGSEEEAEKVGGVDVGEGEGEEEDPGRWVIRANQGHSIKVDAEGLLTPVEVERGNVPDVVVHGTDEGAWNLILKSGGLRRMGRNHIHFASGLPAGFKALDVGEAMGEEKEVPPVISGMRRSSTVLVYVDILAAMEKGVKFFVSENGVILTEGDDKGLLPYEFFKRVENRKKGGGVLMSEGVLPEGVEVDVDAWEKEVGSRGRKGGRGRGRGGRGGRGGQGSGGGKARANDDSGDLLAGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CFV7</accession>
    <name>A0A177CFV7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1164522</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG06206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036571.1">
        <property type="nucleotide sequence ID" value="XM_018178502.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CFV7"/>
    <dbReference type="GeneID" id="28761988"/>
    <dbReference type="InParanoid" id="A0A177CFV7"/>
    <dbReference type="OrthoDB" id="3801185at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="9"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG06206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="486" mass="55568" checksum="08263BE3C3F8E2DF" modified="2016-09-07" version="1">MASFSGCAPELIDSILQHLSFRDLLAVSIVSKRLHKCVTPLLYSQIDMTVHRDNPRSIIHLCRSIFNRPELAAHVDAVRLRDSECFSRWTHFSMNKPPEASPPRPNDEDGMSKFVPFISRSGLAYADIWTEKLRSGDLNAFVALFLSRLPRIKSFRVGNMVVLPDHEKKQQGRDAPTEARDMENQFLGKVFQSAVFDSSNHGISRFRHLQHISYPWLLNPWPGKNPDFCKPKDMMALLSLPSVRSISGWCLNPESLPFSWPTGPPELAYLTSLSLIHVRHDFLGQILERTRVLKKLRWVWSHTPYLDPLNTDILDLDRLTGALLVVQNTLEDLVISTDAGPTWDDPDFQDIDICGSLNGLRNMVNIKRFKVPFALLLSDVYNPSDSYTGRLEDSIPPNVEVVTFSDNYTGFNQGFGSRLHEWPKIASWLLETAWKTTPCLKEVCMFLKPYSPRGPSHELHKLEEIFEGTDVLYNIKHESKDSQRWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2023-06-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CG33</accession>
    <name>A0A177CG33_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_735213</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG05778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036143.1">
        <property type="nucleotide sequence ID" value="XM_018187228.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CG33"/>
    <dbReference type="GeneID" id="28770714"/>
    <dbReference type="InParanoid" id="A0A177CG33"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG05778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="90" mass="9392" checksum="D2C90B07DDFC1C31" modified="2016-09-07" version="1">MTHENPGLFYITLFLAELGARGLSSLSSSNSLNPSARSTPDKFQGCALCTEFMGRASCAGSVQSNDTVCGLLIGVLTRAGEQAMRTSSAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CGB1</accession>
    <name>A0A177CGB1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Voltage-gated potassium channel</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CC84DRAFT_1092033</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG05982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036347.1">
        <property type="nucleotide sequence ID" value="XM_018174426.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CGB1"/>
    <dbReference type="FunCoup" id="A0A177CGB1">
        <property type="interactions" value="16"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CGB1"/>
    <dbReference type="GeneID" id="28757912"/>
    <dbReference type="InParanoid" id="A0A177CGB1"/>
    <dbReference type="OrthoDB" id="297496at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015271">
        <property type="term" value="F:outward rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022841">
        <property type="term" value="F:potassium ion leak channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030322">
        <property type="term" value="P:stabilization of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000182">
        <property type="entry name" value="Outward-rectifier potassium channel TOK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003280">
        <property type="entry name" value="2pore_dom_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003:SF342">
        <property type="entry name" value="OUTWARD-RECTIFIER POTASSIUM CHANNEL TOK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003">
        <property type="entry name" value="POTASSIUM CHANNEL, SUBFAMILY K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01333">
        <property type="entry name" value="2POREKCHANEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5 8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="65"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="121"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="149"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="190"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="231"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="292"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="435"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="469"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="497"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="11">
        <location>
            <begin position="238"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="11">
        <location>
            <begin position="447"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="576"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="756"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="19"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="768"/>
            <end position="777"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OAG05982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="799" mass="91000" checksum="159F3C80CF8C07F2" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CGT3</accession>
    <name>A0A177CGT3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidase M60 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1259354</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG06068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036433.1">
        <property type="nucleotide sequence ID" value="XM_018184905.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CGT3"/>
    <dbReference type="GeneID" id="28768391"/>
    <dbReference type="InParanoid" id="A0A177CGT3"/>
    <dbReference type="OrthoDB" id="3744671at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.30">
        <property type="entry name" value="Peptidase M60, enhancin-like domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042279">
        <property type="entry name" value="Pep_M60_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031161">
        <property type="entry name" value="Peptidase_M60_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF038322">
        <property type="entry name" value="ImpA_fam_HExGH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01276">
        <property type="entry name" value="M60-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51723">
        <property type="entry name" value="PEPTIDASE_M60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M60" evidence="2">
        <location>
            <begin position="628"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG06068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="1233" mass="133181" checksum="99AB7B4CD851D7B3" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CHG2</accession>
    <name>A0A177CHG2_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1215696</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG06651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037016.1">
        <property type="nucleotide sequence ID" value="XM_018182737.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CHG2"/>
    <dbReference type="STRING" id="1460663.A0A177CHG2"/>
    <dbReference type="GeneID" id="28766223"/>
    <dbReference type="InParanoid" id="A0A177CHG2"/>
    <dbReference type="OrthoDB" id="5865767at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37283">
        <property type="entry name" value="PH DOMAIN-CONTAINING PROTEIN YHR131C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37283:SF1">
        <property type="entry name" value="PH DOMAIN-CONTAINING PROTEIN YHR131C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="94"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="306"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="473"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="25"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="339"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="357"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG06651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="544" mass="60496" checksum="63759C42508524B4" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CHU1</accession>
    <name>A0A177CHU1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CC84DRAFT_1143401</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG07093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037458.1">
        <property type="nucleotide sequence ID" value="XM_018176412.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CHU1"/>
    <dbReference type="GeneID" id="28759898"/>
    <dbReference type="InParanoid" id="A0A177CHU1"/>
    <dbReference type="OrthoDB" id="2544694at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF68">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="158"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="185"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="315"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="337"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="370"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="411"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="439"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="19"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAG07093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="527" mass="57861" checksum="FBA717488AFF7E9A" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CHW7</accession>
    <name>A0A177CHW7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pescadillo homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Nucleolar protein 7 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">NOP7</name>
        <name evidence="7" type="ORF">CC84DRAFT_1116716</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the NOP7 complex, composed of ERB1, NOP7 and YTM1. Within the NOP7 complex ERB1 appears to interact directly with NOP7 and YTM1. The NOP7 complex also associates with the 66S pre-ribosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
            <location evidence="4">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
            <location evidence="4">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the pescadillo family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG06831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037196.1">
        <property type="nucleotide sequence ID" value="XM_018175467.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CHW7"/>
    <dbReference type="FunCoup" id="A0A177CHW7">
        <property type="interactions" value="1250"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CHW7"/>
    <dbReference type="GeneID" id="28758953"/>
    <dbReference type="InParanoid" id="A0A177CHW7"/>
    <dbReference type="OrthoDB" id="10264910at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070545">
        <property type="term" value="C:PeBoW complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043021">
        <property type="term" value="F:ribonucleoprotein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000466">
        <property type="term" value="P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd17709">
        <property type="entry name" value="BRCT_pescadillo_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03028">
        <property type="entry name" value="Pescadillo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010613">
        <property type="entry name" value="PES"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12221">
        <property type="entry name" value="PESCADILLO - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12221:SF6">
        <property type="entry name" value="PESCADILLO HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06732">
        <property type="entry name" value="Pescadillo_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="2 4" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="BRCT" evidence="6">
        <location>
            <begin position="347"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="412"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="493"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="499"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="539"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="556"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="572"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="612"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="636"/>
            <end position="652"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAG06831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="669" mass="74756" checksum="B378BE735C1675DE" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CJ02</accession>
    <name>A0A177CJ02_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">POT family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_1117897</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG07504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037869.1">
        <property type="nucleotide sequence ID" value="XM_018175508.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CJ02"/>
    <dbReference type="GeneID" id="28758994"/>
    <dbReference type="InParanoid" id="A0A177CJ02"/>
    <dbReference type="OrthoDB" id="8904098at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006857">
        <property type="term" value="P:oligopeptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000651">
        <property type="entry name" value="Glutathione uptake transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000109">
        <property type="entry name" value="POT_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018456">
        <property type="entry name" value="PTR2_symporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11654">
        <property type="entry name" value="OLIGOPEPTIDE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00854">
        <property type="entry name" value="PTR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01022">
        <property type="entry name" value="PTR2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01023">
        <property type="entry name" value="PTR2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="121"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="150"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="209"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="233"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="327"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="366"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="396"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="434"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="467"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="493"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAG07504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="551" mass="60407" checksum="0DC6D6AA2D6435DD" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CJ11</accession>
    <name>A0A177CJ11_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1087803</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG07251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037616.1">
        <property type="nucleotide sequence ID" value="XM_018174219.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CJ11"/>
    <dbReference type="STRING" id="1460663.A0A177CJ11"/>
    <dbReference type="GeneID" id="28757705"/>
    <dbReference type="InParanoid" id="A0A177CJ11"/>
    <dbReference type="OrthoDB" id="5417135at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42088">
        <property type="entry name" value="YALI0F10131P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42088:SF1">
        <property type="entry name" value="YALI0F10131P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="383"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="469"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="561"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="621"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="225"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="274"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="284"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="312"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="351"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="630"/>
            <end position="648"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG07251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="688" mass="74518" checksum="B130887C01EF5830" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CJA6</accession>
    <name>A0A177CJA6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">FAD-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CC84DRAFT_1241757</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG06919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037284.1">
        <property type="nucleotide sequence ID" value="XM_018184062.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CJA6"/>
    <dbReference type="STRING" id="1460663.A0A177CJA6"/>
    <dbReference type="GeneID" id="28767548"/>
    <dbReference type="InParanoid" id="A0A177CJA6"/>
    <dbReference type="OrthoDB" id="2151789at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF53">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008058227" evidence="5">
        <location>
            <begin position="17"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="6">
        <location>
            <begin position="53"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAG06919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="522" mass="56341" checksum="255B23390A6BAF2A" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CJF2</accession>
    <name>A0A177CJF2_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 14">Delta-aminolevulinic acid dehydratase</fullName>
            <ecNumber evidence="5 14">4.2.1.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CC84DRAFT_1163783</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 14">
            <text>2 5-aminolevulinate = porphobilinogen + 2 H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24064"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58126"/>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <dbReference type="EC" id="4.2.1.24"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 1/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 14">Homooctamer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the ALAD family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.24" evidence="5 14"/>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG07664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038029.1">
        <property type="nucleotide sequence ID" value="XM_018178337.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CJF2"/>
    <dbReference type="FunCoup" id="A0A177CJF2">
        <property type="interactions" value="635"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CJF2"/>
    <dbReference type="GeneID" id="28761823"/>
    <dbReference type="InParanoid" id="A0A177CJF2"/>
    <dbReference type="OrthoDB" id="1530at2759"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00318"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004655">
        <property type="term" value="F:porphobilinogen synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04824">
        <property type="entry name" value="eu_ALAD_PBGS_cysteine_rich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000048">
        <property type="entry name" value="Delta-aminolevulinic acid dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001731">
        <property type="entry name" value="ALAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030656">
        <property type="entry name" value="ALAD_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006762">
        <property type="entry name" value="PRK09283.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11458">
        <property type="entry name" value="DELTA-AMINOLEVULINIC ACID DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11458:SF0">
        <property type="entry name" value="DELTA-AMINOLEVULINIC ACID DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00490">
        <property type="entry name" value="ALAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00144">
        <property type="entry name" value="DALDHYDRTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01004">
        <property type="entry name" value="ALAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00169">
        <property type="entry name" value="D_ALA_DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="10 14" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 14" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="14"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="14"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="28"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00020771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU004161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="OAG07664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="390" mass="42119" checksum="6A47B819911FBFA2" modified="2016-09-07" version="1">MSFSSLVSDIAFRKDADRSDDRDDRRPQVSSGRSMTGDSRPGLSSGRSYASTAATSVSITGDIKSQLHGGYSHPLARSWQAERQLTKSMLIFPLFISDQPDEETVIPALPNQHRRGLNKLVPYLKPLVEKGLRSVILFGVPLAPGAKDALGTSADDPKGPVIKAIRLLRRSFPDLFIVADVCLCEYTSHGHCGILRDDGSLNNALSVDRISDVAMAYAEAGAHCVAPSDMNDGRIRAIKLKLIEAGIAHQVVLMSYSAKFSGVLYGPFRDAAGSCPSFGDRRCYQLPPGGRGLARRAIVRDINEGADIIMVKPASQYLDIISDAKELGKDMPVAAYQVSGEYAMIHAAAKAGVFDLRAMAEEATQGILRAGASIVVSYFTPEFLDWLSEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CJS7</accession>
    <name>A0A177CJS7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Dabb-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1163321</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG07080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037445.1">
        <property type="nucleotide sequence ID" value="XM_018178237.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CJS7"/>
    <dbReference type="STRING" id="1460663.A0A177CJS7"/>
    <dbReference type="GeneID" id="28761723"/>
    <dbReference type="InParanoid" id="A0A177CJS7"/>
    <dbReference type="OrthoDB" id="1601230at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013097">
        <property type="entry name" value="Dabb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044662">
        <property type="entry name" value="HS1/DABB1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33178">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33178:SF10">
        <property type="entry name" value="STRESS-RESPONSE A_B BARREL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07876">
        <property type="entry name" value="Dabb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00886">
        <property type="entry name" value="Dabb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51502">
        <property type="entry name" value="S_R_A_B_BARREL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Stress-response A/B barrel" evidence="2">
        <location>
            <begin position="3"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG07080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="110" mass="12272" checksum="F633E8A1D486D208" modified="2016-09-07" version="1">MAIIHLVFFAWKSDVSKETITDALERLQALELDCVHPISKKPYIKSLKAGANNSPEGVSDPYTHGFVVEFESAEDRDYYVDQDPAHTDFKSFAGPHLAGVKVVDFEPGKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CK22</accession>
    <name>A0A177CK22_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1256832</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG07865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038230.1">
        <property type="nucleotide sequence ID" value="XM_018184668.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CK22"/>
    <dbReference type="GeneID" id="28768154"/>
    <dbReference type="InParanoid" id="A0A177CK22"/>
    <dbReference type="OrthoDB" id="2121326at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG07865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="93" mass="10195" checksum="44EE228A1372174E" modified="2016-09-07" version="1">MATATPITSQAEFDAAIAEPTKFVTIYVHDGPIPEEVRQRFQATAPAFADKAKEKMKLEKLPALLVFKGGKEVDRVYAPGEEEMKALVGKLFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CKM7</accession>
    <name>A0A177CKM7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 13">Fructose-bisphosphate aldolase</fullName>
            <shortName evidence="13">FBP aldolase</shortName>
            <ecNumber evidence="5 13">4.1.2.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CC84DRAFT_1203538</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 13">Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>beta-D-fructose 1,6-bisphosphate = D-glyceraldehyde 3-phosphate + dihydroxyacetone phosphate</text>
            <dbReference type="Rhea" id="RHEA:14729"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="4.1.2.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12 13">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="12 13">Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 13">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 4/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the class II fructose-bisphosphate aldolase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.13" evidence="5 13"/>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038418.1">
        <property type="nucleotide sequence ID" value="XM_018181837.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CKM7"/>
    <dbReference type="FunCoup" id="A0A177CKM7">
        <property type="interactions" value="670"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CKM7"/>
    <dbReference type="GeneID" id="28765323"/>
    <dbReference type="InParanoid" id="A0A177CKM7"/>
    <dbReference type="OrthoDB" id="35652at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00183"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004332">
        <property type="term" value="F:fructose-bisphosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904408">
        <property type="term" value="F:melatonin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061621">
        <property type="term" value="P:canonical glycolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00946">
        <property type="entry name" value="FBP_aldolase_IIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000013">
        <property type="entry name" value="Class II fructose-bisphosphate aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000771">
        <property type="entry name" value="FBA_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006411">
        <property type="entry name" value="Fruct_bisP_bact"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00167">
        <property type="entry name" value="cbbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01520">
        <property type="entry name" value="FruBisAldo_II_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006628">
        <property type="entry name" value="PRK09197.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30559:SF0">
        <property type="entry name" value="FRUCTOSE-BISPHOSPHATE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30559">
        <property type="entry name" value="FRUCTOSE-BISPHOSPHATE ALDOLASE CLASS 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01116">
        <property type="entry name" value="F_bP_aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001359">
        <property type="entry name" value="F_bP_aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00602">
        <property type="entry name" value="ALDOLASE_CLASS_II_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00806">
        <property type="entry name" value="ALDOLASE_CLASS_II_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="9 13" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 12 13" id="KW-0862">Zinc</keyword>
    <feature type="active site" description="Proton donor" evidence="10">
        <location>
            <position position="110"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>dihydroxyacetone phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="266"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="267"/>
            <end position="269"/>
        </location>
        <ligand>
            <name>dihydroxyacetone phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="288"/>
            <end position="291"/>
        </location>
        <ligand>
            <name>dihydroxyacetone phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001359-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR001359-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR001359-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU366023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OAG08053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="360" mass="39884" checksum="4A8378A0ED1BB18B" modified="2016-09-07" version="1">MGAQDVLSRKSGVITGDDVLKLFQHAKENQYAIPAINVTSSSTVVASLEAARDKKSPIILQTSQGGAAFFAGKGVDNKDQAASIAGAVAAAHYIRSIAPAYGIPVVLHTDHCAKKLLPWLDGMLDADEAYFKEHNEPLFSSHMIDLSEEPVDWNIQTTAKYLKRAAPMKQWLEMEIGITGGEEDGVNNEDVDNNSLYTQPEDIYEIYKTLSPISPYFSIAAGFGNVHGVYKPGNVKLQPVLLKKHQDYVKEQTKAKEDKPVFLVFHGGSGSSVDDFREAISYGVVKVNLDTDLQWAYSNGFRDYFKSKEGYLKTQVGNPDGEDKPNKKYYDPRVWVREGEKTMTKRVEVALDDFYTAGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2023-06-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CKU9</accession>
    <name>A0A177CKU9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_557514</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038520.1">
        <property type="nucleotide sequence ID" value="XM_018186685.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CKU9"/>
    <dbReference type="GeneID" id="28770171"/>
    <dbReference type="InParanoid" id="A0A177CKU9"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG08155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="159" mass="17525" checksum="5110FC16EC476BE9" modified="2016-09-07" version="1">MRLVRRSLGVQDPHCLFRTGVNAGFGTIGGLNTRSRVRGSHMLALTVSDLAVPLLPLTASLNDSVLMRHTMFIGLTRWLRIVRMCRLRITASLSSTRLPPWSMQKQTSISLAMAFHVDLPIPLKFGLVIRHGIRGAVRCCSARGGVLHAFGADPRDSRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CLE5</accession>
    <name>A0A177CLE5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Tctex-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1163795</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG07680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038045.1">
        <property type="nucleotide sequence ID" value="XM_018178340.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CLE5"/>
    <dbReference type="STRING" id="1460663.A0A177CLE5"/>
    <dbReference type="GeneID" id="28761826"/>
    <dbReference type="InParanoid" id="A0A177CLE5"/>
    <dbReference type="OrthoDB" id="10059120at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005868">
        <property type="term" value="C:cytoplasmic dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21456">
        <property type="entry name" value="DLC-like_SpDlc1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1140.40">
        <property type="entry name" value="Tctex-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005334">
        <property type="entry name" value="Tctex-1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038586">
        <property type="entry name" value="Tctex-1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21255:SF4">
        <property type="entry name" value="DYNEIN LIGHT CHAIN TCTEX-TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21255">
        <property type="entry name" value="T-COMPLEX-ASSOCIATED-TESTIS-EXPRESSED 1/ DYNEIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03645">
        <property type="entry name" value="Tctex-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG07680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="132" mass="14239" checksum="6E4A7A1DDF7B5D0A" modified="2016-09-07" version="1">MASPLPTDELTEIVRTTVESALASAEKYEHDKVADWNTAIINNLLKTLIEKTTPASQDTSKPAQPAYKYIAHSTIIQHPGAPSDGGAAGRRGMHSAVGAFWNTEKDGTLSYKWDGAEKKGMDVVVSVNWIGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CLF5</accession>
    <name>A0A177CLF5_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Quinate transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CC84DRAFT_1257255</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038749.1">
        <property type="nucleotide sequence ID" value="XM_018184715.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CLF5"/>
    <dbReference type="GeneID" id="28768201"/>
    <dbReference type="InParanoid" id="A0A177CLF5"/>
    <dbReference type="OrthoDB" id="508119at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17356">
        <property type="entry name" value="MFS_HXT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000026">
        <property type="entry name" value="MFS quinate transporter QutD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF34">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0672">Quinate metabolism</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="21"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="125"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="160"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="193"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="285"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="323"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="352"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="384"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="456"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="11">
        <location>
            <begin position="24"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00043213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OAG08384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="537" mass="59616" checksum="329F56618B41D28F" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CLI1</accession>
    <name>A0A177CLI1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CC84DRAFT_1195845</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG07802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038167.1">
        <property type="nucleotide sequence ID" value="XM_018181421.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CLI1"/>
    <dbReference type="STRING" id="1460663.A0A177CLI1"/>
    <dbReference type="GeneID" id="28764907"/>
    <dbReference type="InParanoid" id="A0A177CLI1"/>
    <dbReference type="OrthoDB" id="3903189at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF149">
        <property type="entry name" value="UBID FAMILY DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="94"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="130"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="213"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="247"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="24"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="287"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="291"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="321"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="352"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAG07802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="389" mass="43587" checksum="D486D0AD3DC461E1" modified="2016-09-07" version="1">MAKTPYSGESWIWWIVVLAMIGARLISRKLLFRSIKGLQVDDWVMGLFVATCYTTFIVISNKYLKAGSNLEPSGFDWSAVSARDISRRVYGSKLMIVVEQMLILVIWSCKGCLLVMYHRLTRTALRKENVAIKLLAAYVVLGFVVMELLYFAAWCRPFSLYYAVPTANKQCDTLIDHRITKTVFNVSSDLVMLCIALQMLIRSSLPTKRKMVLCFIFSLGLFTITAAILSLYYSISNSYIHTWLSWYLREVSMAVIVANIPFTWTILRELFEVDEFNASSPQPWSFYPAPRSTTNSNNARLSQATGPSVPNASKHRERSATSRLASQDTQSPTLVGSLSVSKTSGESPSKSLKFEGSERGEMVQIRSHDFAAASSPPAHDHDAISPVLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CLJ0</accession>
    <name>A0A177CLJ0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1205125</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG07720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038085.1">
        <property type="nucleotide sequence ID" value="XM_018181954.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CLJ0"/>
    <dbReference type="STRING" id="1460663.A0A177CLJ0"/>
    <dbReference type="GeneID" id="28765440"/>
    <dbReference type="InParanoid" id="A0A177CLJ0"/>
    <dbReference type="OrthoDB" id="73875at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG07720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="165" mass="18576" checksum="79CFC85E78463710" modified="2016-09-07" version="1">MGGTTDWEYHDVPAPGKSWDQFKLLVASGSDPKTDYSRNGNWTSFHYESEKLNADSAWGNIIWIWKDTDRLTIHVGTNADCGEILLTSNCEQAKDCDKGFNVEDSRALHKDYQDTLFKAASTLNTMLNNFKDKFAPVPPAPNTMWIDFMIDLITLGTVSAWGTFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CN96</accession>
    <name>A0A177CN96_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1162338</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038735.1">
        <property type="nucleotide sequence ID" value="XM_018177965.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CN96"/>
    <dbReference type="GeneID" id="28761451"/>
    <dbReference type="InParanoid" id="A0A177CN96"/>
    <dbReference type="OrthoDB" id="3439035at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="673"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="321"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="89"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="245"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="329"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="361"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="397"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="423"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="472"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG08370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="803" mass="89476" checksum="654D7EDA0BA734AB" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CND9</accession>
    <name>A0A177CND9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">AA1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1162597</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039086.1">
        <property type="nucleotide sequence ID" value="XM_018178038.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CND9"/>
    <dbReference type="GeneID" id="28761524"/>
    <dbReference type="InParanoid" id="A0A177CND9"/>
    <dbReference type="OrthoDB" id="5204141at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008058421" description="AA1-like domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG08721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="121" mass="13295" checksum="EA3B244E4367ABA3" modified="2016-09-07" version="1">MQFTTALMATLMAGTSLATINFGKARYDSGNVDVAIWIDGENACTYVYQGHNNPCDFNGGKFQAQNGFKYTVKDCGNSAFHLENADGSFNSFAHFNPYNNAGSGCANSQGRYHVDQEWSFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CNJ1</accession>
    <name>A0A177CNJ1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_603340</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG09083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039448.1">
        <property type="nucleotide sequence ID" value="XM_018186851.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CNJ1"/>
    <dbReference type="GeneID" id="28770337"/>
    <dbReference type="InParanoid" id="A0A177CNJ1"/>
    <dbReference type="OrthoDB" id="3226064at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="4"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="446"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="446"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG09083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="474" mass="54274" checksum="AF36BB3F96E3310C" modified="2016-09-07" version="1">MTELLDLCYDVLIRILEEIDPEDVGRCAQTSNGFNDFIKKNTRLYKAQYLKNFDDPRRRPTDPEPAWIPQLQRLVRCRKMLESANSDLKRDEFRFIASTLETLIATGSTDALGNSHNQQLITKLFQPIYQNHDAFLCRSSLYDRCGKASQKPADDEEDRQLSAKLLCLFGIPSGNVGNRVLSTHPYARSRVYDLRNYTDKTGWGPFRDDGSMRVDWEMVESLMIVLGYNSGLCGRQFIQRFRPPWTAPLEGVLPARDRILPAYPPKLYTQPEIPLSLRDPYNVSGVWSRIVCFLDYNDLYHYNFNSEAMKVPPDQPREPIQTEEAIRHIVMDLKVTEVLAPGEFENRALPIVKFTGTSRSVDLYGDPNANSKLRGSVRLTPEGEVRWRTISVFYGGEERWRSEGVQVGGVRSQRGVIGTWFDKDMDPHGPAGPTAFWKICDTNELDSEGSEEVDVEVEDEEEDEEDGVWILQEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CPF6</accession>
    <name>A0A177CPF6_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Regulatory P domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1162683</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039207.1">
        <property type="nucleotide sequence ID" value="XM_018178062.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CPF6"/>
    <dbReference type="STRING" id="1460663.A0A177CPF6"/>
    <dbReference type="GeneID" id="28761548"/>
    <dbReference type="InParanoid" id="A0A177CPF6"/>
    <dbReference type="OrthoDB" id="2099887at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027589">
        <property type="entry name" value="Choice_anch_B"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR04312">
        <property type="entry name" value="choice_anch_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38787">
        <property type="entry name" value="REGULATORY P DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38787:SF3">
        <property type="entry name" value="REGULATORY P DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG08842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="484" mass="53645" checksum="7BE8FEBE66C6FFB8" modified="2016-09-07" version="1">MKYAAAIAALAAAAFAKEIPKDPERAAELYDSGVMHERIMADKNAQWDLQDQMGVLNSLAGPQFPELPFAQCKNGLAAPLDPFQSNNASTKFRCNNINLHHFLSHTDLGSAVGKGSSSWGWVSDDGREFAIIAQGDGAAFAEITTAGKLRYLGRLPQTTGVAPSQWREIRTFKHYIVVGSEEPGHGVQIFDLKKLLTIDYKKGPVTFSPDTDLTGYWNDLPLGRVHNVLANSDSNFAYVVGAQPRNSSCLSGLIFLDLTDPSNPKNPGCARDDGYVHDAQCVIYKGPHKKYLGREICYGYNEDSITIYDVTDKQFPETISITSYEGATYTHQGWLLDVNNQEWLISDDEYDEVEGRGVASNGRPVTFIWDIRDLEHPKQTGYYQGPRKNIDHNQYIFGKYSYQSQYTAGLSILDISSIPTDPTGRGVREVGWFDTYPEDDHLEGGGELKFSGSWSNYAGYPSGFILINTMDRGAFVVKTQKPLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CPI7</accession>
    <name>A0A177CPI7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ER membrane protein complex subunit 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CC84DRAFT_1087034</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EMC6 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG09131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039496.1">
        <property type="nucleotide sequence ID" value="XM_018174182.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CPI7"/>
    <dbReference type="FunCoup" id="A0A177CPI7">
        <property type="interactions" value="19"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CPI7"/>
    <dbReference type="GeneID" id="28757668"/>
    <dbReference type="InParanoid" id="A0A177CPI7"/>
    <dbReference type="OrthoDB" id="16510at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072546">
        <property type="term" value="C:EMC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034975">
        <property type="term" value="P:protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008504">
        <property type="entry name" value="Emc6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029008">
        <property type="entry name" value="EMC6-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20994">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20994:SF0">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07019">
        <property type="entry name" value="EMC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="91"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAG09131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="111" mass="12164" checksum="AC2345BA7E4B0DDE" modified="2016-09-07" version="1">MSTFEERELAINPIVVTSVQHNTQVVSNIRNLTASLFGVAAGTLGLESYPGFIFYLVGSFIVSALIFALRTDGKPGDYFHRPLGDLWGGDVFNGLSSFVLTWTLFYGLLRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CPI9</accession>
    <name>A0A177CPI9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1215175</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039064.1">
        <property type="nucleotide sequence ID" value="XM_018182701.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CPI9"/>
    <dbReference type="GeneID" id="28766187"/>
    <dbReference type="InParanoid" id="A0A177CPI9"/>
    <dbReference type="OrthoDB" id="10589854at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG08699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="250" mass="26958" checksum="C8774D8F8D812390" modified="2016-09-07" version="1">MDNHPTKASRFQEEDGPVTTAESGKSRPLTPMKAPQGQNKASVLPEIHHPTRLSPLQKQDSPAKTDDAGRAVSPTPMKALRGHSRSRDNVDATTPAPPDIISKSVRISPKVEREHATGKNSVYDEAIDYPTRDQRDGSAERSRAHGGGEAVASGNGDTPGVQAAERHGLVEQQDSAKEAEKSANLPAAQEASASRRPYDVYTIGKKEASTGEILEGRHAHQAKRAREEQERSDDVKGGAIESREANVLKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CPU7</accession>
    <name>A0A177CPU7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">FAD-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CC84DRAFT_1160445</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG09251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039616.1">
        <property type="nucleotide sequence ID" value="XM_018177504.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CPU7"/>
    <dbReference type="STRING" id="1460663.A0A177CPU7"/>
    <dbReference type="GeneID" id="28760990"/>
    <dbReference type="InParanoid" id="A0A177CPU7"/>
    <dbReference type="OrthoDB" id="2151789at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="entry name" value="Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF54">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="5">
        <location>
            <begin position="42"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAG09251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="480" mass="51511" checksum="05883BE2868A88DC" modified="2016-09-07" version="1">MGDLLHTQAIETLSRAFPHAVLRPGEPRYEEENGRFWNQDNADVRPAGIVAPGDADETAKILQVLSDTKTPFAIRSGGYMPVPGFNTSPSILISLSRLTYVSLLPSPSQDGETPLVKFGAGNTWGRIYDALSPHGLVVPGARSRPIGVGGFLLYGGVSHFYASVGWACEAVTEFEVALASGIVVTANATQNADLFWALKGGGANFGVVTSFTMRTRKLKKLWGGVRVAVGTQLTALQVFTALHEGIQGDVDEKAHVEVITFYSPETCGSGDALFVLSLAYAAEVENPVALKGFLDIEAVSDGTRMTTQRDLAEDDKVNVGYDKRGLFRAFSYRGSAELTLDIYSTYYALVKASGLFDADPSAMAALLWLPAGRNLAAGTGVMALGEEAEPYLSCSICMRWSDPSASARIHAIADSIAEKLKKKPRDAGAFVTFTYGNIAGVQDQTFSGLPEKTRRRLSDVARNYDPEGVFQTQVPGFKLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CQJ4</accession>
    <name>A0A177CQJ4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aminoglycoside phosphotransferas-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1115952</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG09027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039392.1">
        <property type="nucleotide sequence ID" value="XM_018175446.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CQJ4"/>
    <dbReference type="STRING" id="1460663.A0A177CQJ4"/>
    <dbReference type="GeneID" id="28758932"/>
    <dbReference type="InParanoid" id="A0A177CQJ4"/>
    <dbReference type="OrthoDB" id="191037at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05154">
        <property type="entry name" value="ACAD10_11_N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052898">
        <property type="entry name" value="ACAD10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041726">
        <property type="entry name" value="ACAD10_11_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47829:SF1">
        <property type="entry name" value="HAD FAMILY PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47829">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12880)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="30"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG09027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="368" mass="41374" checksum="F8F13D85514EE9B8" modified="2016-09-07" version="1">MAGAVRQPIDIASLESYISSNVPEIAVPIEVKQFGYGQSNPTYQLTDKNGKKYVMRKKPPGTLLSKTAHKVDREYRIIHALEKTDVPVPKAYALCQDEKVIGSDFYIMEFLDGRIFEDPSIPGVTPEERSKMWHSAVTTLAKFHRVVPKDVGLENYGKPSGFYNRQITTFNTISKSQAEAKDKETGIPVGKIPHQDDMVAFFSDPKTQPKDRSSFVHGDYKIDNVVFHKTEPRVIGILDWEMSTIGHPLSDLNNLFAPYLWADKKKSLGSRANEAFLPGKTSGLPSEDQLVAWYSEVAGWDPRSDLTWGHAFSTYRSAIIMQGIAARYALRQASSAQAHEYGSLMKPFAEAAWDLVQEYKRSHQRAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CR77</accession>
    <name>A0A177CR77_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cell morphogenesis protein-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CC84DRAFT_1111897</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040388.1">
        <property type="nucleotide sequence ID" value="XM_018175298.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A177CR77">
        <property type="interactions" value="636"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CR77"/>
    <dbReference type="GeneID" id="28758784"/>
    <dbReference type="InParanoid" id="A0A177CR77"/>
    <dbReference type="OrthoDB" id="6287725at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030427">
        <property type="term" value="C:site of polarized growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025614">
        <property type="entry name" value="Cell_morpho_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025481">
        <property type="entry name" value="Cell_Morphogen_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039867">
        <property type="entry name" value="Furry/Tao3/Mor2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029473">
        <property type="entry name" value="MOR2-PAG1_mid"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12295">
        <property type="entry name" value="FURRY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12295:SF30">
        <property type="entry name" value="PROTEIN FURRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14225">
        <property type="entry name" value="MOR2-PAG1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14228">
        <property type="entry name" value="MOR2-PAG1_mid"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14222">
        <property type="entry name" value="MOR2-PAG1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cell morphogenesis protein N-terminal" evidence="2">
        <location>
            <begin position="330"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="domain" description="Cell morphogenesis central region" evidence="4">
        <location>
            <begin position="953"/>
            <end position="1434"/>
        </location>
    </feature>
    <feature type="domain" description="Cell morphogenesis central region" evidence="4">
        <location>
            <begin position="1438"/>
            <end position="1668"/>
        </location>
    </feature>
    <feature type="domain" description="Cell morphogenesis central region" evidence="4">
        <location>
            <begin position="1736"/>
            <end position="1903"/>
        </location>
    </feature>
    <feature type="domain" description="Cell morphogenesis protein C-terminal" evidence="3">
        <location>
            <begin position="1952"/>
            <end position="2201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="693"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2402"/>
            <end position="2472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2505"/>
            <end position="2555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="135"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="705"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2437"/>
            <end position="2459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="2517"/>
            <end position="2528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAG10023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="2555" mass="285478" checksum="EEBAB2865DA32D13" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CRT2</accession>
    <name>A0A177CRT2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_1083799</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG09469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039834.1">
        <property type="nucleotide sequence ID" value="XM_018174021.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CRT2"/>
    <dbReference type="GeneID" id="28757507"/>
    <dbReference type="InParanoid" id="A0A177CRT2"/>
    <dbReference type="OrthoDB" id="6133115at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000078">
        <property type="entry name" value="MFS maltose transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF10">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="70"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="99"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="155"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="186"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="275"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="308"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="338"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="370"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="404"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="441"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="19"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAG09469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="531" mass="58330" checksum="68D40548C98E4301" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CS05</accession>
    <name>A0A177CS05_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_478808</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040679.1">
        <property type="nucleotide sequence ID" value="XM_018186430.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CS05"/>
    <dbReference type="GeneID" id="28769916"/>
    <dbReference type="InParanoid" id="A0A177CS05"/>
    <dbReference type="OrthoDB" id="2910287at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG10314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="207" mass="22659" checksum="5F5533F5287023AB" modified="2016-09-07" version="1">MVHFSIFPSIALYLFCVLPIIVALPTSRFNHDVQSLPPRNFQENPRTPPASHTHRFRKRGLPGAVYICTSDNFRGDCAWTAPNNRCHIAGTGNNSARSIGPDEDGFCVLFEKATCTGTQVKTLRFPGQASNMPTFMSLKCFSDGNGNGARANATATAVTSNILPDADPRLSGGVGSMERKNLENVMEQMEKDGFRQGMIGLKKGHYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CS91</accession>
    <name>A0A177CS91_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ceramidase</fullName>
            <ecNumber evidence="1">3.5.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1044967</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.5.1.23" evidence="1"/>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG09838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040203.1">
        <property type="nucleotide sequence ID" value="XM_018173410.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CS91"/>
    <dbReference type="STRING" id="1460663.A0A177CS91"/>
    <dbReference type="GeneID" id="28756896"/>
    <dbReference type="InParanoid" id="A0A177CS91"/>
    <dbReference type="OrthoDB" id="5273684at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017040">
        <property type="term" value="F:N-acylsphingosine amidohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.60.10">
        <property type="entry name" value="Penicillin V Acylase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029130">
        <property type="entry name" value="Acid_ceramidase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28583">
        <property type="entry name" value="ACID AMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28583:SF1">
        <property type="entry name" value="ACID CERAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15508">
        <property type="entry name" value="NAAA-beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acid ceramidase N-terminal" evidence="2">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF15508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG09838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="399" mass="45187" checksum="E008E49FB4EDCEEF" modified="2016-09-07" version="1" fragment="single">PPRTVIDLSLPPRERYKSLARSQADKLRSLASLLDELLLDYGVPWRLIKPLHMLSQVFLRQVRSSEETEELKGIAEVTGLPMYLLVAFNVLLDLLMGCTSGGVLSQEDSQPRSSAKMLHFRTLDWTMDPLREVVVQLDFIRSKSSQPDTVLASSITYIGFVGVLTGVRPGLSLSLNFRAVHDATSTKDQVRFYLHHLMVLLGRRPSIASILRHHLLADYRSMGVGQSALELVIDNIAKRHTTAAYLIFSDGHSTITMEKDYSTALTDRSDTFIVRTNHDLNDHGVEPKPIPVVTEDVDIVRRAVHTLDEILDESRERLGCITKQYETKMKMNRASQRRSARALRQNSAQVDKEANLLPTRTEIIQWLCTWTTTNESTHYSVVMDPKAGKVVWCRVYPRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CSI8</accession>
    <name>A0A177CSI8_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CC84DRAFT_1213613</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040631.1">
        <property type="nucleotide sequence ID" value="XM_018182549.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CSI8"/>
    <dbReference type="GeneID" id="28766035"/>
    <dbReference type="InParanoid" id="A0A177CSI8"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd16448">
        <property type="entry name" value="RING-H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024766">
        <property type="entry name" value="Znf_RING_H2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45969:SF81">
        <property type="entry name" value="OS08G0157400 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45969">
        <property type="entry name" value="RING ZINC FINGER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12678">
        <property type="entry name" value="zf-rbx1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="228"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="9">
        <location>
            <begin position="148"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="44"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAG10266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="255" mass="28863" checksum="730BD80E35529BC5" modified="2016-09-07" version="1">MPRATADYPTREDFIWLGVEQLSEVPEDRENSCPICMMPLVPHDSPTTEDGHEFAPVQDDQDLQGSESSFTANITDTHSDLGIITMGTVHAAGTTVFNIAEQDTLNSLVTHWRVVFSVGRHNLNFDDTEELGDTDEPEEGLFIRIRICRHIFHTACLRKWLSKPMNKTCPLCRRLLFAAPCRHTNLLQDLAALEQHVQHGRRQSVEITRLKEEITTLKKTIKNMEKGYVDFLSDCATMVFVAAMIMVALYGMLKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CSN5</accession>
    <name>A0A177CSN5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1172390</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG09900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040265.1">
        <property type="nucleotide sequence ID" value="XM_018179977.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CSN5"/>
    <dbReference type="GeneID" id="28763463"/>
    <dbReference type="InParanoid" id="A0A177CSN5"/>
    <dbReference type="OrthoDB" id="3770625at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG09900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="413" mass="47014" checksum="D2B94059D84C6F9E" modified="2016-09-07" version="1">MPGAASELELAVSGGILLEKRPSNGLDPCFAACAPYESKPLSTRSSASLTTSLFSHDDLLVHFICPDEPMMCAACGCWTRDAVSPQLVDTLRTMINDLEKSISGTIESATAVVKIHRDMLLQLRSQLAVLEKSHSLVMKLEDDHAREMAVVDRRINTMVQNQGYLKIHDQDETILMLHAPKKVLISEHRVAGAAWAAAHAKEESDSKVLIDRTRALLAHTKEAVELEGTIRVAVENEFQQRHREHIAQIADNLLQDGIRVWVSKSNIFATLMTECLLRVADHQLVIEPTKTCFDEDCLRKLYDKYRLNHTCSDMQKTKFTIDMRDVEELKFVKRRATIPGTCDETSPHWEPPRYHQCVYVRTRVSREYYLADRKNEPQDKAWESLRMDVPDGSPNLLCHKLVRYWHDAKQSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CSW1</accession>
    <name>A0A177CSW1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Superoxide dismutase</fullName>
            <ecNumber evidence="13">1.15.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CC84DRAFT_1083975</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Destroys radicals which are normally produced within the cells and which are toxic to biological systems.</text>
    </comment>
    <comment type="function">
        <text evidence="2">Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 13">
            <text>2 superoxide + 2 H(+) = H2O2 + O2</text>
            <dbReference type="Rhea" id="RHEA:20696"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:18421"/>
            <dbReference type="EC" id="1.15.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the iron/manganese superoxide dismutase family.</text>
    </comment>
    <dbReference type="EC" id="1.15.1.1" evidence="13"/>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040656.1">
        <property type="nucleotide sequence ID" value="XM_018174031.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CSW1"/>
    <dbReference type="STRING" id="1460663.A0A177CSW1"/>
    <dbReference type="GeneID" id="28757517"/>
    <dbReference type="InParanoid" id="A0A177CSW1"/>
    <dbReference type="OrthoDB" id="239262at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004784">
        <property type="term" value="F:superoxide dismutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.990:FF:000001">
        <property type="entry name" value="Superoxide dismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.55.40.20:FF:000004">
        <property type="entry name" value="Superoxide dismutase [Fe]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.990">
        <property type="entry name" value="Fe,Mn superoxide dismutase (SOD) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.55.40.20">
        <property type="entry name" value="Iron/manganese superoxide dismutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050265">
        <property type="entry name" value="Fe/Mn_Superoxide_Dismutase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001189">
        <property type="entry name" value="Mn/Fe_SOD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019833">
        <property type="entry name" value="Mn/Fe_SOD_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019832">
        <property type="entry name" value="Mn/Fe_SOD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019831">
        <property type="entry name" value="Mn/Fe_SOD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036324">
        <property type="entry name" value="Mn/Fe_SOD_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036314">
        <property type="entry name" value="SOD_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11404:SF29">
        <property type="entry name" value="SUPEROXIDE DISMUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11404">
        <property type="entry name" value="SUPEROXIDE DISMUTASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02777">
        <property type="entry name" value="Sod_Fe_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00081">
        <property type="entry name" value="Sod_Fe_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000349">
        <property type="entry name" value="SODismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01703">
        <property type="entry name" value="MNSODISMTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54719">
        <property type="entry name" value="Fe,Mn superoxide dismutase (SOD), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46609">
        <property type="entry name" value="Fe,Mn superoxide dismutase (SOD), N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00088">
        <property type="entry name" value="SOD_MN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0464">Manganese</keyword>
    <keyword evidence="6 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Manganese/iron superoxide dismutase N-terminal" evidence="14">
        <location>
            <begin position="5"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="Manganese/iron superoxide dismutase C-terminal" evidence="15">
        <location>
            <begin position="100"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000349-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OAG10291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="217" mass="24175" checksum="6C27B2180D131D74" modified="2016-09-07" version="1">MSAPSYTLPPLPYAYDALEPHISKQIMELHHGKHHQTYITNLNAALKTQAEAVHTSDITSQVGLQAAIKFNAGGHINHSLFWQNLAPASSAEAKTSAAPELIKQINAIWGDEQAFYDAFKTTLLGIQGSGWGWLVKVETGKEQRLTIVTTKDQDPVVGKGEVPIFGIDMWEHAYYLQYLNGKPAYVENIWKVINWKTAEERFLGTRADAFKVLRASI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CT13</accession>
    <name>A0A177CT13_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Carboxypeptidase-like protein A1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CC84DRAFT_1256023</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Extracellular metalloprotease that contributes to pathogenicity.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the peptidase M14 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040493.1">
        <property type="nucleotide sequence ID" value="XM_018184588.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CT13"/>
    <dbReference type="STRING" id="1460663.A0A177CT13"/>
    <dbReference type="GeneID" id="28768074"/>
    <dbReference type="InParanoid" id="A0A177CT13"/>
    <dbReference type="OrthoDB" id="3626597at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03860">
        <property type="entry name" value="M14_CP_A-B_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000165">
        <property type="entry name" value="Glucan 1,4-alpha-glucosidase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057246">
        <property type="entry name" value="CARBOXYPEPT_ZN_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000834">
        <property type="entry name" value="Peptidase_M14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11705">
        <property type="entry name" value="PROTEASE FAMILY M14 CARBOXYPEPTIDASE A,B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11705:SF143">
        <property type="entry name" value="SLL0236 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00246">
        <property type="entry name" value="Peptidase_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00765">
        <property type="entry name" value="CRBOXYPTASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00631">
        <property type="entry name" value="Zn_pept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00132">
        <property type="entry name" value="CARBOXYPEPT_ZN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52035">
        <property type="entry name" value="PEPTIDASE_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="17" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="8 15" id="KW-0732">Signal</keyword>
    <keyword evidence="11" id="KW-0843">Virulence</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="13" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008058558" evidence="15">
        <location>
            <begin position="20"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M14" evidence="16">
        <location>
            <begin position="119"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="14">
        <location>
            <position position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS52035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="OAG10128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="421" mass="45571" checksum="D188EC017D2CC71A" modified="2016-09-07" version="1">MKFFLSESLLLATTVLGTAVPRAEKKVDYTGFKVLRLSLHKATNNIEEQIEKVAAHILNPGKSTLDVVVSPDSVAAVKALVPESIVINEDLGASLAEEGELVSPDFSVSAVPSETWFTAYHPYADHLTFLSDLQGGFPSQSEIFTAGTSVQGRALTGIHIWGSGGKGSKPAVLIHGTVHAREWITTMTTEYFAWQLLTKYASDATVKSLVDKYDYYIIPAVNPDGFVYSQTNDRLWRKNRQTVSSSTCVGRDINRNWPFKWEVTGGASTSPCSETYKGQAAGDAPENKGLVAQVNSLRAGTGIRLYLDIHSYGQYILWPYGYDCSLVVHNSAQHRSIATSAAAAIKAVSGTSYTIGPSCSTLYATTGSSVDYIDATGNATYSYTWELRDTGTYGFQLPASQIQPTVRETWAGLVSTLQNAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CT84</accession>
    <name>A0A177CT84_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1213361</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG09987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040352.1">
        <property type="nucleotide sequence ID" value="XM_018182527.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CT84"/>
    <dbReference type="GeneID" id="28766013"/>
    <dbReference type="InParanoid" id="A0A177CT84"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG09987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="115" mass="12640" checksum="42080BB080AACF3B" modified="2016-09-07" version="1">MDPDTHSDLVALYALYPASSADLTALAPACDPEFCGPAALPSWPSEDPRSPALAPPRLQIEKAYLAIATTPAWREEGVTLVTLNRYDYGGGSEEEAMDGWQREALERGTRRKFWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CT95</accession>
    <name>A0A177CT95_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Enhancer of mRNA-decapping protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_1193681</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">P-body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EDC3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040485.1">
        <property type="nucleotide sequence ID" value="XM_018181321.1"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CT95"/>
    <dbReference type="GeneID" id="28764807"/>
    <dbReference type="InParanoid" id="A0A177CT95"/>
    <dbReference type="OrthoDB" id="10030313at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031087">
        <property type="term" value="P:deadenylation-independent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033962">
        <property type="term" value="P:P-body assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.620.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10260">
        <property type="entry name" value="YjeF N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025762">
        <property type="entry name" value="DFDF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019050">
        <property type="entry name" value="FDF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002931">
        <property type="entry name" value="Transglutaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004443">
        <property type="entry name" value="YjeF_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036652">
        <property type="entry name" value="YjeF_N_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13612">
        <property type="entry name" value="ENHANCER OF MRNA-DECAPPING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13612:SF0">
        <property type="entry name" value="ENHANCER OF MRNA-DECAPPING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09532">
        <property type="entry name" value="FDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01841">
        <property type="entry name" value="Transglut_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03853">
        <property type="entry name" value="YjeF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01199">
        <property type="entry name" value="FDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00460">
        <property type="entry name" value="TGc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64153">
        <property type="entry name" value="YjeF N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51512">
        <property type="entry name" value="DFDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51385">
        <property type="entry name" value="YJEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DFDF" evidence="7">
        <location>
            <begin position="1022"/>
            <end position="1058"/>
        </location>
    </feature>
    <feature type="domain" description="YjeF N-terminal" evidence="6">
        <location>
            <begin position="1214"/>
            <end position="1450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="16"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="765"/>
            <end position="1011"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1070"/>
            <end position="1144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="21"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="91"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="126"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="184"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="210"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="223"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="259"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="765"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="794"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="828"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="902"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="936"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="946"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="963"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="973"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1113"/>
            <end position="1127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAG10120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="1474" mass="159053" checksum="1CAE95B7C2DAD7B4" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CTJ5</accession>
    <name>A0A177CTJ5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cse1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CC84DRAFT_1113489</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the XPO2/CSE1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041220.1">
        <property type="nucleotide sequence ID" value="XM_018175357.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CTJ5"/>
    <dbReference type="FunCoup" id="A0A177CTJ5">
        <property type="interactions" value="1180"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CTJ5"/>
    <dbReference type="GeneID" id="28758843"/>
    <dbReference type="InParanoid" id="A0A177CTJ5"/>
    <dbReference type="OrthoDB" id="3268246at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005049">
        <property type="term" value="F:nuclear export signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046827">
        <property type="term" value="P:positive regulation of protein export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006611">
        <property type="term" value="P:protein export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061015">
        <property type="term" value="P:snRNA import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000057">
        <property type="entry name" value="Exportin-2 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005043">
        <property type="entry name" value="XPO2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013713">
        <property type="entry name" value="XPO2_central"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997:SF8">
        <property type="entry name" value="EXPORTIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997">
        <property type="entry name" value="IMPORTIN-7, 8, 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03378">
        <property type="entry name" value="CAS_CSE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08506">
        <property type="entry name" value="Cse1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="8">
        <location>
            <begin position="24"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAG10855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="958" mass="108350" checksum="9D8ED7BCFAE2A855" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CUC7</accession>
    <name>A0A177CUC7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_496478</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041211.1">
        <property type="nucleotide sequence ID" value="XM_018186528.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CUC7"/>
    <dbReference type="STRING" id="1460663.A0A177CUC7"/>
    <dbReference type="GeneID" id="28770014"/>
    <dbReference type="InParanoid" id="A0A177CUC7"/>
    <dbReference type="OrthoDB" id="5368516at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="138"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="219"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="256"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="295"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="383"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="631"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="632"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="665"/>
            <end position="697"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG10846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="719" mass="78547" checksum="99E3BBC93007A19D" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CUD3</accession>
    <name>A0A177CUD3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Exosome complex protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_1161452</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Required for exosome-dependent processing of pre-rRNA and small nucleolar RNA (snRNA) precursors. Involved in processing of 35S pre-rRNA at the A0, A1 and A2 sites.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the C1D family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040887.1">
        <property type="nucleotide sequence ID" value="XM_018177744.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CUD3"/>
    <dbReference type="STRING" id="1460663.A0A177CUD3"/>
    <dbReference type="GeneID" id="28761230"/>
    <dbReference type="InParanoid" id="A0A177CUD3"/>
    <dbReference type="OrthoDB" id="1421013at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000178">
        <property type="term" value="C:exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000460">
        <property type="term" value="P:maturation of 5.8S rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011082">
        <property type="entry name" value="Exosome-assoc_fac/DNA_repair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007146">
        <property type="entry name" value="Sas10/Utp3/C1D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15341:SF3">
        <property type="entry name" value="NUCLEAR NUCLEIC ACID-BINDING PROTEIN C1D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15341">
        <property type="entry name" value="SUN-COR STEROID HORMONE RECEPTOR CO-REPRESSOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04000">
        <property type="entry name" value="Sas10_Utp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 6" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="41"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="264"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="41"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="294"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="342"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="367"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="406"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU368003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAG10522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="416" mass="45619" checksum="F8A26638C64600AC" modified="2016-09-07" version="1">MKKATLCTSLSGECDYSKKGAGRNSNVVLFPIEALARRAERRKARPARSKKVHSCAASLAHANASSRHSKRSHTTRDCTRLTETLPHSQPEALAPERAAHIAPPSAKHTDTATMDPETNLPDLTDDFETTIDDLEAALAPVLASPLPTLTSTLPTLDKAKLHILTAYTLESLLFSALQASGADAKAHRIFPELARLKTYFGKVTAAEAAGEGKGVQGPSTKLDKDAAARFIRHGLSGNERYDKERAERLAKERARAALKAKQMAERVNKKFDDDVEDQVQEELGKKRKKAVESDSSDDEDEDMEEPAEPAELQAGGSSEDHVDSENAEFYGEDAAPTDTPSKKAKKEKKDKKSSKRRRSGVNVARKSAKDDRPQELILPERGEEPRTRSETFNALLAGSFAEQKKERKKSKKGKKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CUN7</accession>
    <name>A0A177CUN7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1161736</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041286.1">
        <property type="nucleotide sequence ID" value="XM_018177824.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CUN7"/>
    <dbReference type="GeneID" id="28761310"/>
    <dbReference type="InParanoid" id="A0A177CUN7"/>
    <dbReference type="OrthoDB" id="3792666at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="390"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="429"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="440"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG10921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="472" mass="53323" checksum="AC0C671F07A4F934" modified="2016-09-07" version="1">MHKIIDYKRYDPPTIADLEHKVNILKDVENDVGGTVRETVAEGVTMGQVFTDHIKPGKILRLASTVPRIDTPPNKDALERRGSADRYRDYVVFDAFSTGVHAEVGGRTATRARGNYNEIAHMLGLREVKLQLGTPMTHFAQMLDKAYQFIQLGCPVEFDICIRHCTDKQAAILFKCSDPLDSLDYVYKHFPHLRPDFIYKSMPEGTRWIVDPFTNGRHVQFVLGHGTKRDEFGMSNFTKRVLNVQKAVRKGIEEGRVQQLPRGMKSGFAHAVSNKGHEQNTAPMRTRRGDLDRMWKKDENIAANEAKRQVNLRAKMSGGERELEAEVDGAVEENYDAVYTRHLEGDADLSPFLSTSGHLCERALGESYSKSLLGDIQGATHGRLEKEETHATLGERGGHNFTPGSYARDPTDEIPEEKRHLWEAWTAGGQDNDSRYYVPSKKDASKLRDKKWERFSKSQGKGQKGGHKSSRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CV64</accession>
    <name>A0A177CV64_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Molybdopterin synthase catalytic subunit</fullName>
            <ecNumber evidence="4">2.8.1.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Common component for nitrate reductase and xanthine dehydrogenase protein H</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Molybdenum cofactor synthesis protein 2 large subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Molybdenum cofactor synthesis protein 2B</fullName>
            <shortName evidence="4">MOCS2B</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">cnxH</name>
        <name evidence="5" type="ORF">CC84DRAFT_1184603</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalytic subunit of the molybdopterin synthase complex, a complex that catalyzes the conversion of precursor Z into molybdopterin. Acts by mediating the incorporation of 2 sulfur atoms from thiocarboxylated MOCS2A into precursor Z to generate a dithiolene group.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>2 [molybdopterin-synthase sulfur-carrier protein]-C-terminal-Gly-aminoethanethioate + cyclic pyranopterin phosphate + H2O = molybdopterin + 2 [molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-Gly + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:26333"/>
            <dbReference type="Rhea" id="RHEA-COMP:12202"/>
            <dbReference type="Rhea" id="RHEA-COMP:19907"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58698"/>
            <dbReference type="ChEBI" id="CHEBI:59648"/>
            <dbReference type="ChEBI" id="CHEBI:90778"/>
            <dbReference type="ChEBI" id="CHEBI:232372"/>
            <dbReference type="EC" id="2.8.1.12"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Heterotetramer; composed of 2 small (MOCS2A) and 2 large (MOCS2B) subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the MoaE family. MOCS2B subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.12" evidence="4"/>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041004.1">
        <property type="nucleotide sequence ID" value="XM_018180760.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CV64"/>
    <dbReference type="STRING" id="1460663.A0A177CV64"/>
    <dbReference type="GeneID" id="28764246"/>
    <dbReference type="InParanoid" id="A0A177CV64"/>
    <dbReference type="OrthoDB" id="5531344at2759"/>
    <dbReference type="UniPathway" id="UPA00344"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990140">
        <property type="term" value="C:molybdopterin synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030366">
        <property type="term" value="F:molybdopterin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00756">
        <property type="entry name" value="MoaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1170.40:FF:000003">
        <property type="entry name" value="Molybdopterin converting factor subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.40">
        <property type="entry name" value="Molybdopterin biosynthesis MoaE subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03052">
        <property type="entry name" value="MOC2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036563">
        <property type="entry name" value="MoaE_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028888">
        <property type="entry name" value="MOCS2B_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003448">
        <property type="entry name" value="Mopterin_biosynth_MoaE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23404">
        <property type="entry name" value="MOLYBDOPTERIN SYNTHASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02391">
        <property type="entry name" value="MoaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54690">
        <property type="entry name" value="Molybdopterin synthase subunit MoaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 4" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="123"/>
            <end position="124"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="146"/>
            <end position="148"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAG10639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="176" mass="18997" checksum="95A3EC9B8496FB2C" modified="2016-09-07" version="1">MSTTEPPTYKPDIPSEPVTQTTENIHIELTPHALDSLAATRFVRSPSAGATVLFIGTTRDTFNDLPVSSLAYTSYAPLALSTLHNIATTLLAKHALTRIAIIHKLGECPIGEESIVIAVSAPHRQAAWRAGEEALEETKKRAEIWKLERFEGGDGVWRANRDGVMGVRVGEGEGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CW26</accession>
    <name>A0A177CW26_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">NADH-ubiquinone oxidoreductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CC84DRAFT_1184844</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the complex I NDUFA8 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG11007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041372.1">
        <property type="nucleotide sequence ID" value="XM_018180776.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CW26"/>
    <dbReference type="STRING" id="1460663.A0A177CW26"/>
    <dbReference type="GeneID" id="28764262"/>
    <dbReference type="InParanoid" id="A0A177CW26"/>
    <dbReference type="OrthoDB" id="276296at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010625">
        <property type="entry name" value="CHCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016680">
        <property type="entry name" value="NDUFA8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13344:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13344">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06747">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017016">
        <property type="entry name" value="NDUA8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 9" id="KW-0249">Electron transport</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <keyword evidence="11" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="CHCH" evidence="10">
        <location>
            <begin position="91"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR017016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF06747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OAG11007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="154" mass="17646" checksum="774ED7494A539DF8" modified="2016-09-07" version="1">MSSRQPRFNDQALIDTTPLPDDIPKVKELGASSAPLLSASYFIGARCKAYNDDYMMCKTEANGRGELDCMKEGRKVTRCAASVIKDLNEHCLEEFRNHWKCLDNQNHQLWNCRSQERRLNSCVFDKLKLEKVIPDTPKGETPVHLRGRQIFSTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CX72</accession>
    <name>A0A177CX72_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1079099</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG11801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042166.1">
        <property type="nucleotide sequence ID" value="XM_018173824.1"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CX72"/>
    <dbReference type="GeneID" id="28757310"/>
    <dbReference type="InParanoid" id="A0A177CX72"/>
    <dbReference type="OrthoDB" id="5382102at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42105">
        <property type="entry name" value="DIM2-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42105:SF1">
        <property type="entry name" value="TRANSALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="189"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="359"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="836"/>
            <end position="1011"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1027"/>
            <end position="1111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1193"/>
            <end position="1215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1279"/>
            <end position="1725"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="214"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="242"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="297"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="317"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="370"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="446"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="466"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="485"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="496"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="584"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="598"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="616"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="628"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="706"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="736"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="836"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="890"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="957"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="983"/>
            <end position="998"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1027"/>
            <end position="1041"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1064"/>
            <end position="1073"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1074"/>
            <end position="1083"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1299"/>
            <end position="1317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1339"/>
            <end position="1351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1357"/>
            <end position="1375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1440"/>
            <end position="1449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1566"/>
            <end position="1588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1663"/>
            <end position="1672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1683"/>
            <end position="1694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1713"/>
            <end position="1725"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG11801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="1725" mass="190340" checksum="DACB15BCEB4A5DFE" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CXA8</accession>
    <name>A0A177CXA8_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CC84DRAFT_1159516</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042528.1">
        <property type="nucleotide sequence ID" value="XM_018177256.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CXA8"/>
    <dbReference type="STRING" id="1460663.A0A177CXA8"/>
    <dbReference type="GeneID" id="28760742"/>
    <dbReference type="InParanoid" id="A0A177CXA8"/>
    <dbReference type="OrthoDB" id="5392779at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47840:SF1">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47840">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="4">
        <location>
            <begin position="296"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAG12163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="663" mass="74316" checksum="7C68D161CC083517" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CY15</accession>
    <name>A0A177CY15_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_44135</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG11717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042082.1">
        <property type="nucleotide sequence ID" value="XM_018186296.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CY15"/>
    <dbReference type="GeneID" id="28769782"/>
    <dbReference type="InParanoid" id="A0A177CY15"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG11717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="153" mass="18028" checksum="3E8ADBA525131156" modified="2016-09-07" version="1">MIRRARRHYDPPRTARAKFRRQAQYHRSPSHRRNGVARLGTNEVYSGSVLPLIPKRQTRRQRQSEVVLSSRAFVNPGGRYYFPMARYRLFFLDQDASLRALEAEARDVSSWPRFRTGNIGELRAYTTSETYGRGVVRRSSMWMARIELCCTLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CZ67</accession>
    <name>A0A177CZ67_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_64154</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG11979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042344.1">
        <property type="nucleotide sequence ID" value="XM_018186986.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CZ67"/>
    <dbReference type="GeneID" id="28770472"/>
    <dbReference type="InParanoid" id="A0A177CZ67"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG11979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="218" mass="24159" checksum="A10553C8E606BBFA" modified="2016-09-07" version="1">MHARQGFAVSGRYARRRRALVFTRCQPSLSLICNNLSRVTAREEQVKHSYTYFAYIFWTSNGHANTSICGLQTWTLHTETCWWTLLQTDTIPSLGLDSLTIPRSSDILSALTFHHLDGEGGGDGSEGAASKSTTEESQFSKKGQLVSQVLVRRNLSSVPLWSVHANTTEVTARTVHSHTEGYIYTPGDGLYPRRLAPPPRRVPCVYQRCAGFLIGGAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CZG1</accession>
    <name>A0A177CZG1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_98854</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042657.1">
        <property type="nucleotide sequence ID" value="XM_018188058.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CZG1"/>
    <dbReference type="GeneID" id="28771544"/>
    <dbReference type="InParanoid" id="A0A177CZG1"/>
    <dbReference type="OrthoDB" id="3800943at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="243"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="292"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="528"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="698"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="799"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="250"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="292"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="328"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="536"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="552"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="703"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="826"/>
            <end position="835"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG12292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="835" mass="89363" checksum="C8349567432ED111" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CZN5</accession>
    <name>A0A177CZN5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nagb/rpia/CoA transferase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1211986</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the eIF-2B alpha/beta/delta subunits family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042792.1">
        <property type="nucleotide sequence ID" value="XM_018182416.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CZN5"/>
    <dbReference type="STRING" id="1460663.A0A177CZN5"/>
    <dbReference type="GeneID" id="28765902"/>
    <dbReference type="InParanoid" id="A0A177CZN5"/>
    <dbReference type="OrthoDB" id="206213at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046523">
        <property type="term" value="F:S-methyl-5-thioribose-1-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019509">
        <property type="term" value="P:L-methionine salvage from methylthioadenosine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10470">
        <property type="entry name" value="Translation initiation factor eif-2b, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000649">
        <property type="entry name" value="IF-2B-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042529">
        <property type="entry name" value="IF_2B-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43475">
        <property type="entry name" value="METHYLTHIORIBOSE-1-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43475:SF3">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_2G14290)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01008">
        <property type="entry name" value="IF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG12427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="449" mass="48693" checksum="D414C485DD218158" modified="2016-09-07" version="1">MATVGYPNLDSYTQNTLALEFPEPGPASVGMQQNEKKCRWTRLKRVMGQSLTSRSTSSVKSLKPLSPISETDSAIYSIRAGPSSVTEDAQTTTWEDSEYDKQLNEAVSGLKNDFVSGAREMADSALSSLSSLIVVAAAAALNRDELWNMTISAAKELSSARPSMNAAITSCLLGALDDLSKLWDSLDKKRNKPPDELAAMASRQMVRTLEKRKEAGMRLSENFAERLRAYCSQRLNNTHTLTILTLSNSSTIRASILTTLSTLRFLHLILLVLESRPRFEGASMASQILSATSAEARGRLKIHILPDCAVATVAKDAQLVLLGADRISASGDVSNKIGSLAAAVCIKTLNPKAQVVVVSDADKIVAKGVEEGEKETHPASEMLEGWGDETRRDLAARIVDGSVEVFGEWFEWVPAEYVDGYVTENGTLDTSGVEKVAEEIGELREKIFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CZU1</accession>
    <name>A0A177CZU1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1171331</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018043016.1">
        <property type="nucleotide sequence ID" value="XM_018179906.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CZU1"/>
    <dbReference type="GeneID" id="28763392"/>
    <dbReference type="InParanoid" id="A0A177CZU1"/>
    <dbReference type="OrthoDB" id="5429002at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008058806" evidence="2">
        <location>
            <begin position="17"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="125"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="145"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG12651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="193" mass="18209" checksum="E69E2180DE65B92C" modified="2016-09-07" version="1">MRAYAFVSALAAVAFAQDSSSEAASSSIDPAPQTSYLQQTNSLGVVTGGPAVATSQPAVDTSIPAQPAADTSIPLLVTSLPAGASIPAQPSGINTVVIPVGNNSTIQVVVSASNSTTIVYGSPNSATGSATTGTGKASGTGKASGSGAEATGSDATGSGATGTGAQSTSTPGAAANVQIASGFLGAAFLAAFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CZW3</accession>
    <name>A0A177CZW3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">PAN2-PAN3 deadenylation complex catalytic subunit PAN2</fullName>
            <ecNumber evidence="10">3.1.13.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">PAB1P-dependent poly(A)-specific ribonuclease</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Poly(A)-nuclease deadenylation complex subunit 2</fullName>
            <shortName evidence="10">PAN deadenylation complex subunit 2</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">PAN2</name>
        <name evidence="13" type="ORF">CC84DRAFT_1192595</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein PAB1. PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. May also be involved in post-transcriptional maturation of mRNA poly(A) tails.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Exonucleolytic cleavage of poly(A) to 5'-AMP.</text>
            <dbReference type="EC" id="3.1.13.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="10">Binds 2 metal cations per subunit in the catalytic exonuclease domain.</text>
    </comment>
    <comment type="activity regulation">
        <text evidence="10">Positively regulated by the regulatory subunit PAN3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Forms a heterotrimer with an asymmetric homodimer of the regulatory subunit PAN3 to form the poly(A)-nuclease (PAN) deadenylation complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="10">Contains a pseudo-UCH domain. This ubiquitin C-terminal hydrolase (UCH)-like or ubiquitin specific protease (USP)-like domain is predicted to be catalytically inactive because it lacks the active site catalytic triad characteristic of thiol proteases, with residues at the equivalent structural positions that are incompatible with catalysis, and it cannot bind ubiquitin. It functions as a structural scaffold for intra- and intermolecular interactions in the complex.</text>
    </comment>
    <comment type="domain">
        <text evidence="10">The linker, or PAN3 interaction domain (PID), between the WD40 repeats and the pseudo-UCH domain mediates interaction with PAN3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the peptidase C19 family. PAN2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.1.13.4" evidence="10"/>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042765.1">
        <property type="nucleotide sequence ID" value="XM_018181253.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CZW3"/>
    <dbReference type="FunCoup" id="A0A177CZW3">
        <property type="interactions" value="667"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CZW3"/>
    <dbReference type="GeneID" id="28764739"/>
    <dbReference type="InParanoid" id="A0A177CZW3"/>
    <dbReference type="OrthoDB" id="16516at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031251">
        <property type="term" value="C:PAN complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004535">
        <property type="term" value="F:poly(A)-specific ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000289">
        <property type="term" value="P:nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06143">
        <property type="entry name" value="PAN2_exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02672">
        <property type="entry name" value="Peptidase_C19P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000459">
        <property type="entry name" value="PAN2-PAN3 deadenylation complex catalytic subunit PAN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000028">
        <property type="entry name" value="PAN2-PAN3 deadenylation complex catalytic subunit PAN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000135">
        <property type="entry name" value="PAN2-PAN3 deadenylation complex catalytic subunit pan2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03182">
        <property type="entry name" value="PAN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030843">
        <property type="entry name" value="PAN2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050785">
        <property type="entry name" value="PAN2-PAN3_catalytic_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048841">
        <property type="entry name" value="PAN2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028881">
        <property type="entry name" value="PAN2_UCH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15728">
        <property type="entry name" value="DEADENYLATION COMPLEX CATALYTIC SUBUNIT PAN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15728:SF0">
        <property type="entry name" value="PAN2-PAN3 DEADENYLATION COMPLEX CATALYTIC SUBUNIT PAN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20770">
        <property type="entry name" value="PAN2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13423">
        <property type="entry name" value="UCH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 10" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="8 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 10" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 10" id="KW-0540">Nuclease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="USP" evidence="12">
        <location>
            <begin position="492"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="400"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1117"/>
            <end position="1145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="404"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="888"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="890"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="997"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="1050"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OAG12400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="1145" mass="127136" checksum="7B6C837932593C69" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177D0F0</accession>
    <name>A0A177D0F0_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RNA helicase</fullName>
            <ecNumber evidence="4">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CC84DRAFT_163225</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits and is required for the normal formation of 25S and 5.8S rRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DEAD box helicase family. DDX54/DBP10 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="4"/>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018043243.1">
        <property type="nucleotide sequence ID" value="XM_018185434.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177D0F0"/>
    <dbReference type="FunCoup" id="A0A177D0F0">
        <property type="interactions" value="1037"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177D0F0"/>
    <dbReference type="GeneID" id="28768920"/>
    <dbReference type="InParanoid" id="A0A177D0F0"/>
    <dbReference type="OrthoDB" id="10261375at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17959">
        <property type="entry name" value="DEADc_DDX54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000865">
        <property type="entry name" value="ATP-dependent RNA helicase DDX54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012541">
        <property type="entry name" value="DBP10_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033517">
        <property type="entry name" value="DDX54/DBP10_DEAD-box_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF8">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08147">
        <property type="entry name" value="DBP10CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01123">
        <property type="entry name" value="DBP10CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0347">Helicase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="18">
        <location>
            <begin position="79"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="16">
        <location>
            <begin position="110"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="17">
        <location>
            <begin position="332"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="21"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="324"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="614"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="657"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="801"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="14">
        <location>
            <begin position="79"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="325"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="657"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="673"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="833"/>
            <end position="894"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="OAG12878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="902" mass="98998" checksum="7E477317C9E43029" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177D145</accession>
    <name>A0A177D145_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mannitol 2-dehydrogenase</fullName>
            <ecNumber evidence="4">1.1.1.67</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CC84DRAFT_1183421</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the NAD(H)-dependent interconversion of D-fructose and D-mannitol in the mannitol metabolic pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>D-mannitol + NAD(+) = D-fructose + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12084"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16899"/>
            <dbReference type="ChEBI" id="CHEBI:37721"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.67"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the mannitol dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.67" evidence="4"/>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018043257.1">
        <property type="nucleotide sequence ID" value="XM_018180686.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177D145"/>
    <dbReference type="FunCoup" id="A0A177D145">
        <property type="interactions" value="52"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177D145"/>
    <dbReference type="GeneID" id="28764172"/>
    <dbReference type="InParanoid" id="A0A177D145"/>
    <dbReference type="OrthoDB" id="418169at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050086">
        <property type="term" value="F:mannitol 2-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046029">
        <property type="term" value="F:mannitol dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000129">
        <property type="entry name" value="D-mannonate oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000669">
        <property type="entry name" value="Mannitol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050988">
        <property type="entry name" value="Mannitol_DH/Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013118">
        <property type="entry name" value="Mannitol_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013131">
        <property type="entry name" value="Mannitol_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43362:SF1">
        <property type="entry name" value="MANNITOL DEHYDROGENASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43362">
        <property type="entry name" value="MANNITOL DEHYDROGENASE DSF1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01232">
        <property type="entry name" value="Mannitol_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08125">
        <property type="entry name" value="Mannitol_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00084">
        <property type="entry name" value="MTLDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mannitol dehydrogenase N-terminal" evidence="8">
        <location>
            <begin position="36"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="Mannitol dehydrogenase C-terminal" evidence="9">
        <location>
            <begin position="297"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00040250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00058571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAG12892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="514" mass="57196" checksum="FA4EBF53C53BE237" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177D253</accession>
    <name>A0A177D253_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_180630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG13129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018043494.1">
        <property type="nucleotide sequence ID" value="XM_018185486.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177D253"/>
    <dbReference type="GeneID" id="28768972"/>
    <dbReference type="InParanoid" id="A0A177D253"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG13129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="111" mass="12683" checksum="75B035A9C95F4670" modified="2016-09-07" version="1">MDGTLKTFCLRNHCVVFLLVLPETPRPKQATGSNGFGFEEARLETLLKNSREGGIRYASLSHTLVVEKRGPQRAMHSMTCMRSNEREIRGLVFFSFFTFLLVSSYEPHSRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BTB3</accession>
    <name>A0A177BTB3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Zf-U1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CC84DRAFT_1105819</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="8">Component of the U1 snRNP. The U1 snRNP is composed of the U1 snRNA and the 7 core Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP, and at least 3 U1 snRNP-specific proteins SNRNP70/U1-70K, SNRPA/U1-A and SNRPC/U1-C. SNRPC/U1-C interacts with U1 snRNA and the 5' splice-site region of the pre-mRNA. Interacts (via N-terminus) with TIA1 (via C-terminus); thereby promoting spliceosomal U1 snRNP recruitment to 5' splice sites.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441565">
        <property type="protein sequence ID" value="OAF98633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018028999.1">
        <property type="nucleotide sequence ID" value="XM_018175114.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BTB3"/>
    <dbReference type="STRING" id="1460663.A0A177BTB3"/>
    <dbReference type="GeneID" id="28758600"/>
    <dbReference type="InParanoid" id="A0A177BTB3"/>
    <dbReference type="OrthoDB" id="76567at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030627">
        <property type="term" value="F:pre-mRNA 5'-splice site binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000395">
        <property type="term" value="P:mRNA 5'-splice site recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000059">
        <property type="entry name" value="U1 small nuclear ribonucleoprotein C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03153">
        <property type="entry name" value="U1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000690">
        <property type="entry name" value="Matrin/U1-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013085">
        <property type="entry name" value="U1-CZ_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017340">
        <property type="entry name" value="U1_snRNP-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31148">
        <property type="entry name" value="U1 SMALL NUCLEAR RIBONUCLEOPROTEIN C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31148:SF1">
        <property type="entry name" value="U1 SMALL NUCLEAR RIBONUCLEOPROTEIN C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06220">
        <property type="entry name" value="zf-U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037969">
        <property type="entry name" value="U1_snRNP-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50171">
        <property type="entry name" value="ZF_MATRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Matrin-type" evidence="10">
        <location>
            <begin position="6"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="71"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="79"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="136"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OAF98633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="167" mass="17322" checksum="B063C55BEE5EBDC3" modified="2016-09-07" version="1" fragment="single">AKMPKFFCDYCDVYLTHDSMSVRKAHNAGRNHLRNVQAYYEQISSEQTQLVINSITDAYNAEGQANPMTQNPMGGLGGFPPPGGPGFPPHGFPPPGPGGPMPPGGMPFPPPNMAGGPPPNMPFPFPPPGQAGSPPGGMPFPPPGAMPPRGFPPFPPPNAGPPGPPGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BUL1</accession>
    <name>A0A177BUL1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1181975</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441564">
        <property type="protein sequence ID" value="OAF98825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029191.1">
        <property type="nucleotide sequence ID" value="XM_018180587.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BUL1"/>
    <dbReference type="GeneID" id="28764073"/>
    <dbReference type="InParanoid" id="A0A177BUL1"/>
    <dbReference type="OrthoDB" id="2910287at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAF98825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="198" mass="19815" checksum="F56F36421F8A78AC" modified="2016-09-07" version="1">MRALSYLAHAIALRTSPFTPDTAKCSPTLGVPGGGMSSPSSILPTPTEFPCTAYICPIPSACTWHPPSSSPACITLETSVSGPPTLIGPDAGGQCLLYSSPACAPESVLGVPEDAAGAGQTDETKGSVVCPRIGGAVVPGGVRGVRCFATGAGKVEAKEGEDVKRPLGVPVTHGTPGVGHYWGRGYGGGRDIDAAIST</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BUV2</accession>
    <name>A0A177BUV2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Homoserine O-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CC84DRAFT_1199986</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. MetX family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441562">
        <property type="protein sequence ID" value="OAF99253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029619.1">
        <property type="nucleotide sequence ID" value="XM_018181644.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BUV2"/>
    <dbReference type="FunCoup" id="A0A177BUV2">
        <property type="interactions" value="127"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177BUV2"/>
    <dbReference type="GeneID" id="28765130"/>
    <dbReference type="InParanoid" id="A0A177BUV2"/>
    <dbReference type="OrthoDB" id="191364at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004414">
        <property type="term" value="F:homoserine O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071266">
        <property type="term" value="P:'de novo' L-methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009092">
        <property type="term" value="P:homoserine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00296">
        <property type="entry name" value="MetX_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008220">
        <property type="entry name" value="HAT_MetX-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01392">
        <property type="entry name" value="homoserO_Ac_trn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32268">
        <property type="entry name" value="HOMOSERINE O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32268:SF11">
        <property type="entry name" value="HOMOSERINE O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000443">
        <property type="entry name" value="Homoser_Ac_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="5">
        <location>
            <begin position="71"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="254"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="169"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="420"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000443-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAF99253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="510" mass="55439" checksum="CF2C2AC4AA5741A7" modified="2016-09-07" version="1">MSTAQADGASSNGTHKYQRVTEQPENPFAKLIPDQTFAIIPEVTLESGAVLRNVPVAYKTYGTLSPTGDNAMVICHALTGSADVGDWWGPMLGGPGKAFDISRFFVVCINSLGSPYGSASPVTAKDGDPSLGQYGPEFPLTTVRDDVNIFKLILDDLGVRQIAAVIGGSMGGMLVLEFAYFGKDYVKSIIPIATSARYSAWGISWGEAQRQSIYSDPKYEDGYYTCEDPPSTGLGAARMSALLTYRSRDSFESRFGRNTPDLSKKQSINAVPRPSTPANEHWAIHNHGHKNAGSPRVSRTNSTVGLSTSANTADLEFKDASNPPSPPVQAKPIGVSQFQKSRTPHYFSAQSYLRYQGEKFIKRFDANCYIAITRKLDTHDVSRHRYPEGFETETLDPVLALQHALSLIEQPTLVLGIQSDGLFTFAEQQELAAHIPNAKLKTIDSPDGHDAFLLEFEQVNGHLCGFLNEVLPEIMTRTPNVDSAGLADSGLNATKTSTFGEAEVEDITAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BUV4</accession>
    <name>A0A177BUV4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HET-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1050485</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441562">
        <property type="protein sequence ID" value="OAF99172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029538.1">
        <property type="nucleotide sequence ID" value="XM_018173468.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BUV4"/>
    <dbReference type="STRING" id="1460663.A0A177BUV4"/>
    <dbReference type="GeneID" id="28756954"/>
    <dbReference type="InParanoid" id="A0A177BUV4"/>
    <dbReference type="OrthoDB" id="5386682at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF73">
        <property type="entry name" value="HET DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_8G01020)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="18"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAF99172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="111" mass="12674" checksum="279977B2BDC17040" modified="2016-09-07" version="1" fragment="single">DLSTCGLCTVNTETAPPYKTLFYVWGPENSLKEFLLNGQALDVRKHLWDFEIQSNHGEEKEMSLGSLSDDTEYIWIDALCIDQRNLKERLHQVAIMGDIYSSATHVLVWLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BVD8</accession>
    <name>A0A177BVD8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HET-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1157302</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441562">
        <property type="protein sequence ID" value="OAF99362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029728.1">
        <property type="nucleotide sequence ID" value="XM_018177006.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BVD8"/>
    <dbReference type="STRING" id="1460663.A0A177BVD8"/>
    <dbReference type="GeneID" id="28760492"/>
    <dbReference type="InParanoid" id="A0A177BVD8"/>
    <dbReference type="OrthoDB" id="2288928at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF80">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26639">
        <property type="entry name" value="Het-6_barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="142"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAF99362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="679" mass="76387" checksum="8A958F84AC0CA54E" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BVI8</accession>
    <name>A0A177BVI8_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Prolyl 4-hydroxylase alpha subunit domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_1169896</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KV441564">
        <property type="protein sequence ID" value="OAF98741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029107.1">
        <property type="nucleotide sequence ID" value="XM_018179782.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BVI8"/>
    <dbReference type="STRING" id="1460663.A0A177BVI8"/>
    <dbReference type="GeneID" id="28763268"/>
    <dbReference type="InParanoid" id="A0A177BVI8"/>
    <dbReference type="OrthoDB" id="420380at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031418">
        <property type="term" value="F:L-ascorbic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004656">
        <property type="term" value="F:procollagen-proline 4-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.620:FF:000027">
        <property type="entry name" value="Oxidoreductase, 2OG-Fe(II) oxygenase family family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045054">
        <property type="entry name" value="P4HA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006620">
        <property type="entry name" value="Pro_4_hyd_alph"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044862">
        <property type="entry name" value="Pro_4_hyd_alph_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869">
        <property type="entry name" value="PROLYL 4-HYDROXYLASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869:SF246">
        <property type="entry name" value="TRANSMEMBRANE PROLYL 4-HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13640">
        <property type="entry name" value="2OG-FeII_Oxy_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00702">
        <property type="entry name" value="P4Hc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="Prolyl 4-hydroxylase alpha subunit" evidence="7">
        <location>
            <begin position="85"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAF98741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="304" mass="33936" checksum="C95C41A59653C43A" modified="2016-09-07" version="1">MTSRSFPFASILQYIVLVIIGYILAGAPLLSFVIGPTPDNQKARAGTGRPSPLSLDKAAGLVIPERNLSCTEHMYKGLHVLSRDPLVVYVEGFLREDEVQHVVDVSQMHFSPSTVWSSGHERLDPTVRLSEKAPVPRSPAVRCIEERARAFQGWRPYVFVEKLWAQKYGPGGHYAYHYDWSNALRGAGRVSSFMVWLGDQCEGGGTRFPRLERPKDEAWCRFIDCEGDASEDKGDADEDEMGMGVTFKPIRGNAVYWENMRTDGTGYEESWHAGLPVTSGTKLGLNIWSWLQEGYQPLPPEGAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BVQ6</accession>
    <name>A0A177BVQ6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PLP-dependent transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CC84DRAFT_1169940</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the trans-sulfuration enzymes family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441564">
        <property type="protein sequence ID" value="OAF98811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029177.1">
        <property type="nucleotide sequence ID" value="XM_018179795.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BVQ6"/>
    <dbReference type="FunCoup" id="A0A177BVQ6">
        <property type="interactions" value="162"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177BVQ6"/>
    <dbReference type="GeneID" id="28763281"/>
    <dbReference type="InParanoid" id="A0A177BVQ6"/>
    <dbReference type="OrthoDB" id="3512640at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016846">
        <property type="term" value="F:carbon-sulfur lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000072">
        <property type="entry name" value="Putative cystathionine beta-lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000066">
        <property type="entry name" value="Putative cystathionine beta-lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054542">
        <property type="entry name" value="Cys_met_metab_PP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11808:SF35">
        <property type="entry name" value="CYSTATHIONINE GAMMA-SYNTHASE (AFU_ORTHOLOGUE AFUA_7G01590)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11808">
        <property type="entry name" value="TRANS-SULFURATION ENZYME FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001434">
        <property type="entry name" value="CGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00868">
        <property type="entry name" value="CYS_MET_METAB_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="3">
        <location>
            <position position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001434-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAF98811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="441" mass="47793" checksum="5DF8B6B42E7D9B32" modified="2016-09-07" version="1">MPKPLSAATAAVHADDHINVLTDVAPAIHTSTTFRYPRNHADLQPVETGSSHSFPALQTPLVYSRLASANINRLETVLAPLIYPNTPESELENLANHVVSYSSGLSAFHALLVNVVPKVIAISEGYHGCHGVIGLHKKMHGVRTVDLHADEKAWDDAGLGKGDIVHLETPLNPTGEAFSIQKYADRAHKRGALLSVDATFGPPGLQDPFAWGADVVMHSGTKYIGGHSDILCGILAVKKGEEGYKMAGKLREERLFMGSVLGSLEGWLGVRSLRTLELRVQRQSSNATKLVEWLSEALKGNGEGSDVVSEVVSEVTHASLQTSDFPWLKKQMPNGFGPVFSFYTKTPDLARQLPSHLRLFHHATSLGGVESLIEWRRMSDSGVDERLLRVSVGVESWEDLRDDLVQAFEKLAAGEKVENGVSLDVQTRGRGAKMEGGDGAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BVU8</accession>
    <name>A0A177BVU8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1223588</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441564">
        <property type="protein sequence ID" value="OAF98851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029217.1">
        <property type="nucleotide sequence ID" value="XM_018183507.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BVU8"/>
    <dbReference type="STRING" id="1460663.A0A177BVU8"/>
    <dbReference type="GeneID" id="28766993"/>
    <dbReference type="InParanoid" id="A0A177BVU8"/>
    <dbReference type="OrthoDB" id="4521980at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAF98851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="218" mass="24567" checksum="D9BB76C0E967509A" modified="2016-09-07" version="1">MIAVEQPQSPSLLKRSTSMFRRFSKRESRPVLPVSPGPSPLPSPRKLQRRPTNKDPTAKMITHLQTIEFSEKAPAVGSPRREVELRRRVLASDMRTMPFPASPCVQTVAWNVFLTPEQAYSLVMGFRPRETDDKWFIYSEGPDHSGKLKVHFHRSWTGMKIAELFVVIDLKGEGAGKIVGIKWDGSDQTNGLEQEEVKYMVSTACAFVLEISLENGVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BW92</accession>
    <name>A0A177BW92_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CC84DRAFT_1169731</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441563">
        <property type="protein sequence ID" value="OAF99011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029377.1">
        <property type="nucleotide sequence ID" value="XM_018179742.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BW92"/>
    <dbReference type="FunCoup" id="A0A177BW92">
        <property type="interactions" value="56"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177BW92"/>
    <dbReference type="GeneID" id="28763228"/>
    <dbReference type="InParanoid" id="A0A177BW92"/>
    <dbReference type="OrthoDB" id="4977at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005869">
        <property type="term" value="C:dynactin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028133">
        <property type="entry name" value="Dynamitin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15346">
        <property type="entry name" value="DYNACTIN SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04912">
        <property type="entry name" value="Dynamitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="358"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="60"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="88"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="103"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="113"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAF99011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="418" mass="46712" checksum="83E0B8F5F315394B" modified="2016-09-07" version="1">MAEASKVKYDSLPGIDTAPDVYETPELAEDVSTIPASTAVSDSEGDDDPESSAVRHQHLQTDQARSRFQPSRVDANGVDFSDNISARRSYRTSTRARRRGDILGDDSDEEQESFERKLMRVKQELQELEGEHQERVKSGDKSKVEERDPKEIIEFISEKVDQIYAMRRGGVRGAEPQLDRTIDKFNNYAPFEPSSRITKAIANQPPLPGSQVQRGQLEFVLDQAKQFDERLSKLETSLGLDGTTMPDLGDKAPFPVFATLERIEQTVGLVGDASQGNLEAASAQIKKMIADAEQLKELRAEGSRDGESPNSEQEAKINALYGTLPSIDKLSPVLPMMLERLRTLRLVHTSAWAADDVLTELENRQSQQEAEIKKWEQSIQEVEADVKKCEAAMQSNMHTVGDWVKTIEERVAKLPRGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BWG8</accession>
    <name>A0A177BWG8_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Amino acid permease/ SLC12A domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_429534</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441565">
        <property type="protein sequence ID" value="OAF98669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029035.1">
        <property type="nucleotide sequence ID" value="XM_018186205.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BWG8"/>
    <dbReference type="GeneID" id="28769691"/>
    <dbReference type="InParanoid" id="A0A177BWG8"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAF98669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="77" mass="8660" checksum="355EAF8BC231E115" modified="2016-09-07" version="1">MLAMRTPTLTRSRMFQHEKYRCLGAQIPVGLISRVCCNLILVGVAFSSAFREDSAFVLYRICSVLCCSFLNPVVSRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2023-06-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BWI1</accession>
    <name>A0A177BWI1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1181297</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441561">
        <property type="protein sequence ID" value="OAF99843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030209.1">
        <property type="nucleotide sequence ID" value="XM_018180548.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BWI1"/>
    <dbReference type="GeneID" id="28764034"/>
    <dbReference type="InParanoid" id="A0A177BWI1"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAF99843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="237" mass="25857" checksum="F381EB9A43193CD9" modified="2016-09-07" version="1">MQHLPSNRHGRHRVVDVAKWRSPMAARCSDSLPAHIITASSTAINSAPATTVPTGQSRPLSTKDEIRASLAGTHAVTILACFANTERAPAYLNACLFLGTIHFPLYSYQCIAGSSGRKRTPSHMLVSRDSIFIKMGADLCKAITARRRRHLLPARLQYRTNSGTSPPDRGTTLAVKVLSSHVCDLDDFVSGLVARSEQIKHQPNSTDYFTASRPSCPPPMQGRISRFDCGEGVDARF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BWL6</accession>
    <name>A0A177BWL6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1223209</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441563">
        <property type="protein sequence ID" value="OAF98897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029263.1">
        <property type="nucleotide sequence ID" value="XM_018183471.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BWL6"/>
    <dbReference type="GeneID" id="28766957"/>
    <dbReference type="InParanoid" id="A0A177BWL6"/>
    <dbReference type="OrthoDB" id="3745771at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="187"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAF98897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="250" mass="27192" checksum="BE94F0E560348B6A" modified="2016-09-07" version="1">MAKGRVRQILLTVFRVIQFILSLVALVCGIYITYVYYDMASSAHDLLEAIDTLDPENDGVQILEHSLVPVLHHFDGTPMRAILILVAALWSSLSIISLFFADRAARHSPRDLKRNSRTTRVTISVLTLILWIAAIICSALLTVEFGVFALVAGPETKVALTTSEKILLEAMQQIAESIDPISDAMNIVGSIMTIGFMAILLLVASIVNTKVALWNCVIACCMSGKGMNKKVTKDQAMMEKGGVQVSVASV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BWM0</accession>
    <name>A0A177BWM0_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Post-SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_1190718</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441560">
        <property type="protein sequence ID" value="OAF99883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030249.1">
        <property type="nucleotide sequence ID" value="XM_018181134.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BWM0"/>
    <dbReference type="STRING" id="1460663.A0A177BWM0"/>
    <dbReference type="GeneID" id="28764620"/>
    <dbReference type="InParanoid" id="A0A177BWM0"/>
    <dbReference type="OrthoDB" id="5984008at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053201">
        <property type="entry name" value="Flavunoidine_N-MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003616">
        <property type="entry name" value="Post-SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12350">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12350:SF19">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50868">
        <property type="entry name" value="POST_SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Post-SET" evidence="3">
        <location>
            <begin position="158"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAF99883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="202" mass="22350" checksum="9EF2FE6BFB294554" modified="2016-09-07" version="1">MPPAAITTSAPPPTNGKAAAVKSSAEPIIIPSGRLNGPSDVVPAWVKPDLTRLLRVEHLEGDFAARSVSLVDLPAGATFARISNPTPAKCAYTSVQASRDLHIELNCDLVYINHSCRPTLVFDMQRWEVRVNPDLKEGLKAGDELTFFYPSTEFDMSQPFDCRCKEKNCRGTISGAKDMSLEVLRQYWLNPHIEELLQERIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BYH1</accession>
    <name>A0A177BYH1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Succinate dehydrogenase assembly factor 3</fullName>
            <shortName evidence="8">SDH assembly factor 3</shortName>
            <shortName evidence="8">SDHAF3</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CC84DRAFT_380764</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 8">Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Promotes maturation of the iron-sulfur protein subunit of the SDH catalytic dimer, protecting it from the deleterious effects of oxidants. May act together with SDHAF1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 8">Interacts with the iron-sulfur protein subunit within the SDH catalytic dimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 8">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the complex I LYR family. SDHAF3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV441561">
        <property type="protein sequence ID" value="OAF99738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030104.1">
        <property type="nucleotide sequence ID" value="XM_018185972.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BYH1"/>
    <dbReference type="FunCoup" id="A0A177BYH1">
        <property type="interactions" value="254"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177BYH1"/>
    <dbReference type="GeneID" id="28769458"/>
    <dbReference type="InParanoid" id="A0A177BYH1"/>
    <dbReference type="OrthoDB" id="278329at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015976">
        <property type="term" value="P:carbon utilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034553">
        <property type="term" value="P:mitochondrial respiratory chain complex II assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006111">
        <property type="term" value="P:regulation of gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006105">
        <property type="term" value="P:succinate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20270">
        <property type="entry name" value="Complex1_LYR_SDHAF3_LYRM10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008381">
        <property type="entry name" value="SDHAF3/Sdh7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13137">
        <property type="entry name" value="DC11 ACN9 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13137:SF6">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE ASSEMBLY FACTOR 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13233">
        <property type="entry name" value="Complex1_LYR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6 8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU368039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAF99738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="137" mass="15749" checksum="EA105B629D753431" modified="2016-09-07" version="1">MRVYSRLLATASNAGASNSFRPTPMALLPPIPLYRRLLRAHRKLPKEERTLGDLYVKKEFRAHKDIDNPVHIVGFLSEWQMYAQQLSGDAWKDAKMDSAKVDKMSDQQIGQLYELMTAIRKQELDDNEAEKESGNEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BZ92</accession>
    <name>A0A177BZ92_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">D-amino-acid oxidase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_1168075</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DAMOX/DASOX family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441558">
        <property type="protein sequence ID" value="OAG00844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031209.1">
        <property type="nucleotide sequence ID" value="XM_018179313.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BZ92"/>
    <dbReference type="STRING" id="1460663.A0A177BZ92"/>
    <dbReference type="GeneID" id="28762799"/>
    <dbReference type="InParanoid" id="A0A177BZ92"/>
    <dbReference type="OrthoDB" id="2015447at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003884">
        <property type="term" value="F:D-amino-acid oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019478">
        <property type="term" value="P:D-amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006181">
        <property type="entry name" value="D-amino_acid_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023209">
        <property type="entry name" value="DAO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11530">
        <property type="entry name" value="D-AMINO ACID OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11530:SF16">
        <property type="entry name" value="D-AMINO ACID OXIDASE (AFU_ORTHOLOGUE AFUA_5G11290)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000189">
        <property type="entry name" value="D-aa_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51971">
        <property type="entry name" value="Nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00677">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="7">
        <location>
            <begin position="9"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="50"/>
            <end position="51"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="246"/>
        </location>
        <ligand>
            <name>D-dopa</name>
            <dbReference type="ChEBI" id="CHEBI:149689"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="306"/>
        </location>
        <ligand>
            <name>D-dopa</name>
            <dbReference type="ChEBI" id="CHEBI:149689"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="334"/>
        </location>
        <ligand>
            <name>D-dopa</name>
            <dbReference type="ChEBI" id="CHEBI:149689"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000189-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAG00844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="361" mass="39659" checksum="03CFBC2C1E48B95B" modified="2016-09-07" version="1">MPSKHGNEFVVLGAGVIGLSSALALREAYPSSAITVVAKHFPGDRSIDYTSPWAGANWSSMATDNGPLEGYDRVTFNRFAKMVDEGLGDVVGVGRMGLRAVFDAEIEQVNVLSQGTGKIWYEELVGGMRFLEERELPQGAVFGLDFKSTFRLNTQVYLNWLQQQAIEKGIKTVRRHYPSIKAILEDYPSTTALVNCSALGSLHLEDVKDTNLYPTRGQTILVAEPKVPIERMYLRTPKRVDPTVAYVFPRPNGGGVILGGSRQDNDWSAEPDMSLAQTIMQRCCSLCPELGKPEDLQVISHNVGLRPSRKGGPRIEVERWADGTPVVHNYGHAGAGYQSSWGTAERVVELVGKALEKKARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BZD2</accession>
    <name>A0A177BZD2_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Acyl-CoA desaturase</fullName>
            <ecNumber evidence="16">1.14.19.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CC84DRAFT_1222719</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Stearoyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>octadecanoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (9Z)-octadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:19721"/>
            <dbReference type="Rhea" id="RHEA-COMP:10438"/>
            <dbReference type="Rhea" id="RHEA-COMP:10439"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57387"/>
            <dbReference type="ChEBI" id="CHEBI:57394"/>
            <dbReference type="EC" id="1.14.19.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="16">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="16">Expected to bind 2 Fe(2+) ions per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the fatty acid desaturase type 1 family.</text>
    </comment>
    <dbReference type="EC" id="1.14.19.1" evidence="16"/>
    <dbReference type="EMBL" id="KV441561">
        <property type="protein sequence ID" value="OAF99709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030075.1">
        <property type="nucleotide sequence ID" value="XM_018183407.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BZD2"/>
    <dbReference type="FunCoup" id="A0A177BZD2">
        <property type="interactions" value="900"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177BZD2"/>
    <dbReference type="GeneID" id="28766893"/>
    <dbReference type="InParanoid" id="A0A177BZD2"/>
    <dbReference type="OrthoDB" id="10260134at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004768">
        <property type="term" value="F:stearoyl-CoA 9-desaturase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006636">
        <property type="term" value="P:unsaturated fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03505">
        <property type="entry name" value="Delta9-FADS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000004">
        <property type="entry name" value="Acyl-CoA desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009160">
        <property type="entry name" value="Acyl-CoA_deSatase_haem/ster-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015876">
        <property type="entry name" value="Acyl-CoA_DS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001522">
        <property type="entry name" value="FADS-1_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11351">
        <property type="entry name" value="ACYL-COA DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11351:SF31">
        <property type="entry name" value="DESATURASE 1, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000345">
        <property type="entry name" value="OLE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00075">
        <property type="entry name" value="FACDDSATRASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00476">
        <property type="entry name" value="FATTY_ACID_DESATUR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 16" id="KW-0249">Electron transport</keyword>
    <keyword evidence="15 16" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="8 16" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5 16" id="KW-0349">Heme</keyword>
    <keyword evidence="12 16" id="KW-0408">Iron</keyword>
    <keyword evidence="4 16" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="13 16" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="14 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 16" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 16" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="26"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="173"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="18">
        <location>
            <begin position="322"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRNR" id="PIRNR000345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="OAF99709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="448" mass="50905" checksum="237D34EB0DA2630D" modified="2016-09-07" version="1">MGVKRPQTKVHISDQPVTLQNWYKHINWFSTTLVVLVPTYGLYACRYVPLTAATAIWAVIYYFFTGFGITGGYHRLWSHRCYNARLPLRLFLAFVGAGAIQGSIRFWSSKHRAHHRWTDTQKDPYCALKGFFHAHVGWMVLKQDPKKIGRTDISDLDADPVVVWQHKHYGKSLLVAAWLFPMCVAGLGWGDWWGGLVYAGIMRACFVQQATFCVNSLAHWLGEQPFDDRRTPRDHFITALVTLGEGYHNFHHEFPSDYRNAIAWYQYDPTKWLIFLLSKTTLAYDLKRFRHNEIEKGRLQQQQKALDARRSTLDWGLPLSQLPVLSWEEFQARCASGEAALVAIAGIIHDVTDFIAEHPGGKALIKGWVGKDATAVFNGGVYMHSNAAHNLLSTIRVGVLRGGQEVEVWKEERETYVKDKMGQIVVRANNHITNVRPLVATADAASIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BZK7</accession>
    <name>A0A177BZK7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_360740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441560">
        <property type="protein sequence ID" value="OAG00149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030514.1">
        <property type="nucleotide sequence ID" value="XM_018185905.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BZK7"/>
    <dbReference type="STRING" id="1460663.A0A177BZK7"/>
    <dbReference type="GeneID" id="28769391"/>
    <dbReference type="InParanoid" id="A0A177BZK7"/>
    <dbReference type="OrthoDB" id="2603at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG00149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="146" mass="16480" checksum="A06D6F5BFA0D3FDB" modified="2016-09-07" version="1">MNASATIRSAYVRASMMLEFQARLIVLFSSAIFMFAGIVDFPRIISKESPLFASIVFGPQVIHGFLFLFANAMLAISEQHKWYIPKISDPDWLGAFLNATGGFWFMMAGFFFFQKDELAAAAAAMVGSWAFLVRSLVRWYVVMEFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C0A2</accession>
    <name>A0A177C0A2_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1221459</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441558">
        <property type="protein sequence ID" value="OAG00905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031270.1">
        <property type="nucleotide sequence ID" value="XM_018183276.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C0A2"/>
    <dbReference type="GeneID" id="28766762"/>
    <dbReference type="InParanoid" id="A0A177C0A2"/>
    <dbReference type="OrthoDB" id="5229512at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038883">
        <property type="entry name" value="AN11006-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085:SF2">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG00905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="424" mass="48832" checksum="0CAC719C0DEC3663" modified="2016-09-07" version="1">MPRHFQFLDLPREIREIIYEALLCNWELNHTRERAYLSTRFDNPTAILRLNHQIYSEAFDYLVKHNQFISVDCDGISIRSDPLGRQILAVTEDPKKIGQFNGYVARIKWSTNKDPLQKIRRKQYMVLGRQLPDLLKCTDYHVMTQWPAITMTIAINPIRTSRTDLTTPSLRPFQISLLHIIPTLLHAFPGLTIEGTAVPRRLAGHIIRETARPRWMTPAAALADLLWFKHNNDRLANEAYYLSTNTAIECGLKTIDYMRASPGWPELILAGGRSFVNAVAELAFELRVARAQRALDAMERSQSRRNLVEEFSEHVNADLAKCLPPVPSDGDEAFWEPNQEQVAVVLCMHARKHRLLLDVESRDAAVGLVERALQMVPDNEAVRRESIAVAAWSRRVDRYINEVWVSSSGAMEEMWQWWEQEVEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C0V5</accession>
    <name>A0A177C0V5_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CC84DRAFT_1128976</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the U5 snRNP complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DEAD box helicase family. DDX23/PRP28 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="KV441559">
        <property type="protein sequence ID" value="OAG00347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030712.1">
        <property type="nucleotide sequence ID" value="XM_018175816.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C0V5"/>
    <dbReference type="FunCoup" id="A0A177C0V5">
        <property type="interactions" value="881"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177C0V5"/>
    <dbReference type="GeneID" id="28759302"/>
    <dbReference type="InParanoid" id="A0A177C0V5"/>
    <dbReference type="OrthoDB" id="196131at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17945">
        <property type="entry name" value="DEADc_DDX23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000322">
        <property type="entry name" value="probable ATP-dependent RNA helicase DDX23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057479">
        <property type="entry name" value="PRP28/DDX23-like_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25430">
        <property type="entry name" value="DDX23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101447">
        <property type="entry name" value="Formin homology 2 domain (FH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 14" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="4 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="18">
        <location>
            <begin position="351"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="16">
        <location>
            <begin position="382"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="17">
        <location>
            <begin position="591"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="743"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="13">
        <location>
            <begin position="351"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="15">
        <location>
            <begin position="9"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="80"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="99"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="134"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="745"/>
            <end position="756"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00037954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="OAG00347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="774" mass="85723" checksum="176513A7794E5C35" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C115</accession>
    <name>A0A177C115_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DUF1000-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CC84DRAFT_1129318</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioredoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441559">
        <property type="protein sequence ID" value="OAG00532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030897.1">
        <property type="nucleotide sequence ID" value="XM_018175827.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C115"/>
    <dbReference type="STRING" id="1460663.A0A177C115"/>
    <dbReference type="GeneID" id="28759313"/>
    <dbReference type="InParanoid" id="A0A177C115"/>
    <dbReference type="OrthoDB" id="2121326at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02947">
        <property type="entry name" value="TRX_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.470">
        <property type="entry name" value="PITH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010400">
        <property type="entry name" value="PITH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037047">
        <property type="entry name" value="PITH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46115">
        <property type="entry name" value="THIOREDOXIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06201">
        <property type="entry name" value="PITH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51532">
        <property type="entry name" value="PITH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="3">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="PITH" evidence="4">
        <location>
            <begin position="132"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAG00532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="333" mass="36323" checksum="0470353925D27816" modified="2016-09-07" version="1">MSGSTQISSPEQLRTLLSSSRIVVVNFYNEWNPACKTISPVYDQLAASLARPGVVSFAKVNAEQQTQIAQSYGATNPPLFVIFKNGNQVSKFTGTNPQQLSDNIRKLAAEVESGEGGFGEASGSSGGAGGWRGAGLPRGYTDVTDQVDVRGLDLLNSDSEFGGVRTLFDTTQPSSAGKGKAAGESKRDWVESDVDEQLMLYLPFTSTLKVHTIQITSFPPKADDDDDDEDEVPLRPKTIHLYTNRQHNLGFEEAEDIAPTQTFELQPSDWDESTGTAKLELRFVKFQNVYSLVLFVVDGDGDGEKTRIDRIRIIGESGEKREMGKLEKVGADD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C1E8</accession>
    <name>A0A177C1E8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1180294</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441558">
        <property type="protein sequence ID" value="OAG01256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031621.1">
        <property type="nucleotide sequence ID" value="XM_018180465.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C1E8"/>
    <dbReference type="GeneID" id="28763951"/>
    <dbReference type="InParanoid" id="A0A177C1E8"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="11"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG01256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="173" mass="18555" checksum="8292D516E1E49BDB" modified="2016-09-07" version="1">MHALFGRANRHRLAKNLRPAARPHQRREPSQFTARNPLSASAAGTLQRALARKCAPLGVKAYGAFVAAARLEWLDKRARAQSRLRGGCHPQDLAMQLTSPVGCERALPTSSVTPPERPLSIHRPRKPDAVCSLRHGGDILQSGSSTASFRILSSTDAATPAPIVGPSQRVCCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C1W7</accession>
    <name>A0A177C1W7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ras-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1168291</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441558">
        <property type="protein sequence ID" value="OAG01151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031516.1">
        <property type="nucleotide sequence ID" value="XM_018179363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C1W7"/>
    <dbReference type="STRING" id="1460663.A0A177C1W7"/>
    <dbReference type="GeneID" id="28762849"/>
    <dbReference type="InParanoid" id="A0A177C1W7"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007033">
        <property type="term" value="P:vacuole organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00154">
        <property type="entry name" value="Rab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050209">
        <property type="entry name" value="Rab_GTPases_membrane_traffic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47979">
        <property type="entry name" value="DRAB11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG01151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="290" mass="31293" checksum="9FE59092B2D03DA8" modified="2016-09-07" version="1">MYDYLAKIILLGPSGAGKSCMLHRFVNSSWKILSSQTIGVEFASKIVHIHPRDPSRGTRKRIKLQLWDTAGTERFRSVSRSYYRGAAGAILVYDVSSWRSFEGLRTYMEDVRALASPDCTMILAGNKMDVAEEGGGRIGGSSSASSYSDGLDSAAASVSSRSTIPALSHSKATVAPEGREVPFDTASRWAGQNGIPVAVEVSAFSGENVDELFERLARMILTKIELGEIDPDDPQSGIQYGDIGGWGIDDGNESIRSRGGRRGGGGNGQLREWEEVFRLSGSTGRRKGCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C2W5</accession>
    <name>A0A177C2W5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Extracellular sulfatase Sulf-2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CC84DRAFT_1199123</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfatase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441558">
        <property type="protein sequence ID" value="OAG01097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031462.1">
        <property type="nucleotide sequence ID" value="XM_018181601.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C2W5"/>
    <dbReference type="STRING" id="1460663.A0A177C2W5"/>
    <dbReference type="GeneID" id="28765087"/>
    <dbReference type="InParanoid" id="A0A177C2W5"/>
    <dbReference type="OrthoDB" id="103349at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16031">
        <property type="entry name" value="G6S_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024607">
        <property type="entry name" value="Sulfatase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43108">
        <property type="entry name" value="N-ACETYLGLUCOSAMINE-6-SULFATASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43108:SF6">
        <property type="entry name" value="N-SULPHOGLUCOSAMINE SULPHOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00523">
        <property type="entry name" value="SULFATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00149">
        <property type="entry name" value="SULFATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Sulfatase N-terminal" evidence="6">
        <location>
            <begin position="5"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="241"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAG01097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="532" mass="61000" checksum="86E7B09F98EF3391" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C2W8</accession>
    <name>A0A177C2W8_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Phosphotransferase</fullName>
            <ecNumber evidence="8">2.7.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CC84DRAFT_1154882</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 1/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the hexokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.-" evidence="8"/>
    <dbReference type="EMBL" id="KV441558">
        <property type="protein sequence ID" value="OAG01249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031614.1">
        <property type="nucleotide sequence ID" value="XM_018176915.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C2W8"/>
    <dbReference type="STRING" id="1460663.A0A177C2W8"/>
    <dbReference type="GeneID" id="28760401"/>
    <dbReference type="InParanoid" id="A0A177C2W8"/>
    <dbReference type="OrthoDB" id="419537at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00180"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005536">
        <property type="term" value="F:D-glucose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008865">
        <property type="term" value="F:fructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004340">
        <property type="term" value="F:glucokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001678">
        <property type="term" value="P:intracellular glucose homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000034">
        <property type="entry name" value="Phosphotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.367.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001312">
        <property type="entry name" value="Hexokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022673">
        <property type="entry name" value="Hexokinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022672">
        <property type="entry name" value="Hexokinase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443:SF30">
        <property type="entry name" value="GLUCOKINASE-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443">
        <property type="entry name" value="HEXOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00349">
        <property type="entry name" value="Hexokinase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03727">
        <property type="entry name" value="Hexokinase_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00475">
        <property type="entry name" value="HEXOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51748">
        <property type="entry name" value="HEXOKINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 8" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="5 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Hexokinase N-terminal" evidence="9">
        <location>
            <begin position="11"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="Hexokinase C-terminal" evidence="10">
        <location>
            <begin position="219"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="Hexokinase C-terminal" evidence="10">
        <location>
            <begin position="466"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OAG01249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="530" mass="58347" checksum="A202C6EF564C19E5" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C3C0</accession>
    <name>A0A177C3C0_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SWIRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1221148</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441557">
        <property type="protein sequence ID" value="OAG01661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032026.1">
        <property type="nucleotide sequence ID" value="XM_018183234.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C3C0"/>
    <dbReference type="STRING" id="1460663.A0A177C3C0"/>
    <dbReference type="GeneID" id="28766720"/>
    <dbReference type="InParanoid" id="A0A177C3C0"/>
    <dbReference type="OrthoDB" id="5598695at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000087">
        <property type="entry name" value="Transcriptional adapter 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007526">
        <property type="entry name" value="SWIRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04433">
        <property type="entry name" value="SWIRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50934">
        <property type="entry name" value="SWIRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SWIRM" evidence="2">
        <location>
            <begin position="295"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="283"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG01661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="392" mass="43752" checksum="7E1B9734FDD909D7" modified="2016-09-07" version="1">MANNSHHWPATPSQGIPVSSLLSPPEMKRSESFGSLAHSNSATSFGSFASMDSQQSKPPSVLPWNTFPTKSNTTATYALASPPISPYETCMENENTDRMEVDGVRDPPLFRRSETVSSIAGDEPLFPQEQVDTTSQDLITKHMNSSKFAALKHKPAREDYELAVTFVSNVHDLYRKDPRAWFLQERKFDEQISQKRAGVHKREPLKKLAPAPSSRSQAKLPKVGIPRLPRSPRAPRVQKRTPKAQVYDSFSEAGPSSVSPKPARPAGTRDDTDYNSLPDYSPPLSTLGTGNSSALKTEWKGSALKLHDDPDRHLLHEAEIPLAGTLRLSCATYLCSKRRIFQARIEALKIGKEFRKTDAQQACKIDVNKASKLWAVYDKVGWFDPKYFVRFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C3K6</accession>
    <name>A0A177C3K6_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Nucleolar GTP-binding protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CC84DRAFT_1179459</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 7">Involved in the biogenesis of the 60S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 7">Nucleus</location>
            <location evidence="2 7">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. NOG subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV441557">
        <property type="protein sequence ID" value="OAG01368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031733.1">
        <property type="nucleotide sequence ID" value="XM_018180418.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C3K6"/>
    <dbReference type="FunCoup" id="A0A177C3K6">
        <property type="interactions" value="1234"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177C3K6"/>
    <dbReference type="GeneID" id="28763904"/>
    <dbReference type="InParanoid" id="A0A177C3K6"/>
    <dbReference type="OrthoDB" id="415015at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902626">
        <property type="term" value="P:assembly of large subunit precursor of preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000054">
        <property type="term" value="P:ribosomal subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01897">
        <property type="entry name" value="NOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000496">
        <property type="entry name" value="Nucleolar GTP-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024926">
        <property type="entry name" value="NOG1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041623">
        <property type="entry name" value="NOG1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010674">
        <property type="entry name" value="NOG1_Rossman_fold_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012973">
        <property type="entry name" value="NOG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45759">
        <property type="entry name" value="NUCLEOLAR GTP-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06858">
        <property type="entry name" value="NOG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17835">
        <property type="entry name" value="NOG1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08155">
        <property type="entry name" value="NOGCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038919">
        <property type="entry name" value="NOG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="OBG-type G" evidence="9">
        <location>
            <begin position="169"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="544"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="579"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="595"/>
            <end position="613"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR038919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAG01368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="654" mass="73952" checksum="AC895ACF86050649" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C4W1</accession>
    <name>A0A177C4W1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Proteasome subunit alpha type</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_1221246</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="4">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the peptidase T1A family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441557">
        <property type="protein sequence ID" value="OAG01767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032132.1">
        <property type="nucleotide sequence ID" value="XM_018183248.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C4W1"/>
    <dbReference type="FunCoup" id="A0A177C4W1">
        <property type="interactions" value="957"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177C4W1"/>
    <dbReference type="GeneID" id="28766734"/>
    <dbReference type="InParanoid" id="A0A177C4W1"/>
    <dbReference type="OrthoDB" id="431557at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034515">
        <property type="term" value="C:proteasome storage granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010499">
        <property type="term" value="P:proteasomal ubiquitin-independent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd03753">
        <property type="entry name" value="proteasome_alpha_type_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000015">
        <property type="entry name" value="Proteasome subunit alpha type-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033812">
        <property type="entry name" value="Proteasome_alpha_type_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003075">
        <property type="entry name" value="PRK03996.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00388">
        <property type="entry name" value="PROTEASOME_ALPHA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 5 6" id="KW-0647">Proteasome</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome alpha-type subunits" evidence="7">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00026071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAG01767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="290" mass="32044" checksum="5B62B72919B67610" modified="2016-09-07" version="1">MQRHYNACALPVRDTFYPSFYPSVEAKDDAPYPRPFHESSTNTLNMFIARSEYDRGINTFSPEGRLFQVEYSLEAIKLGSTAIGVATGEGVILGVEKRVTSTLLETSSVEKIVEIDRHIGCAMSGLQADARSMVEHARVESQNHAFNYAEPLRVESCTQAICDLALRFGEGADGEESIMSRPFGVALLIAGYDEDGPSLYHAEPSGTFYRYDAKAIGSGSEGAQAELQNEFHKSLTLSEAEVMVLKTLKQVMEEKLDSKNVQLASVTKEKGFRIYTDTEMEEVVGRLPTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C567</accession>
    <name>A0A177C567_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1221286</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441557">
        <property type="protein sequence ID" value="OAG01820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032185.1">
        <property type="nucleotide sequence ID" value="XM_018183255.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C567"/>
    <dbReference type="GeneID" id="28766741"/>
    <dbReference type="InParanoid" id="A0A177C567"/>
    <dbReference type="OrthoDB" id="3886371at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG01820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="403" mass="45122" checksum="06691250ABB51088" modified="2016-09-07" version="1">MSPYQHLFSTNAVLNVWRNLRTRDQNDLLLSFHVQPDDVRAARDPRYGKGGVVETTSDESGRKNTVVDGRGAIDGRSIGFVVPWRSMQAQKKELREKEKELADALVVLAGEVSFADLPPALQSSLTQNPLIQVRHLAAGLSRQMSRVEVQMADNEPFATGKNLYSGGELIRKYLPDIETLFQQRPTPQRMIFELLLELKDLVYAGMQACEREVIEWDLTNFSSFEDLDEALVRAITPLPSDETARAGSSAGPRKLLRRKASSMSILSRPWLHDEAEILFHLESLDTTAAAMSHLAVPITDFAAKAAITLRRTLPRQVLNDHSLVKRKRTGRCAEYARCMKWAGTSWRQGGGCRRGCKNEDEDPESLPSWHSSSRWFDERGTYMVGGGRGSVEGRAAVPTVREM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C6J1</accession>
    <name>A0A177C6J1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Apple domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1167063</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG03374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033739.1">
        <property type="nucleotide sequence ID" value="XM_018179112.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C6J1"/>
    <dbReference type="GeneID" id="28762598"/>
    <dbReference type="InParanoid" id="A0A177C6J1"/>
    <dbReference type="OrthoDB" id="4927749at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008057801" description="Apple domain-containing protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG03374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="162" mass="16628" checksum="59710516E507D2F8" modified="2016-09-07" version="1">MRTLLFSILAVVAILSGSTLAVKGVISDTLTSDEEGCLSLCGLNDACLLALYQTECRECWLMDCSLQFMPVGFTGGGKDTIKIKPTCDSALVPKPREDGCKDAPAATTSAAAATTTSAATATTTSGAARSSETGVKGSATWRTSIDWLPLGAVVMANIVVAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C6K1</accession>
    <name>A0A177C6K1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Acid protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CC84DRAFT_1219704</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG02751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033116.1">
        <property type="nucleotide sequence ID" value="XM_018183101.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C6K1"/>
    <dbReference type="STRING" id="1460663.A0A177C6K1"/>
    <dbReference type="GeneID" id="28766587"/>
    <dbReference type="InParanoid" id="A0A177C6K1"/>
    <dbReference type="OrthoDB" id="4074350at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05471">
        <property type="entry name" value="pepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034164">
        <property type="entry name" value="Pepsin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47965">
        <property type="entry name" value="ASPARTYL PROTEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47965:SF101">
        <property type="entry name" value="HYPOTHETICAL ASPARTYL PROTEASE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="451"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="4">
        <location>
            <begin position="49"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="422"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="520"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="586"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="10"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="425"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="539"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAG02751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="637" mass="69068" checksum="11A1822B608C1B6F" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C795</accession>
    <name>A0A177C795_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Mg2+ transporter protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CC84DRAFT_908274</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG02648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033013.1">
        <property type="nucleotide sequence ID" value="XM_018187854.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C795"/>
    <dbReference type="STRING" id="1460663.A0A177C795"/>
    <dbReference type="GeneID" id="28771340"/>
    <dbReference type="InParanoid" id="A0A177C795"/>
    <dbReference type="OrthoDB" id="3801263at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046873">
        <property type="term" value="F:metal ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045863">
        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="183"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="214"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAG02648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="257" mass="29339" checksum="FED005BC6832A720" modified="2016-09-07" version="1">MEHFQALLRFRPTEEILLSMVEYPADLLVMKTSFQVLMDLTTWHLNLGELATVARELDTDATANPSKMVIQRLSKGRSLVLQVLSDVIRLREVTKNYPSDNYKLLSQVMVIVKLEYPEIDWIQEEQYSLSADVSIILRVLSRLEQQAEELSSQLCETFQTLTTAIAIEDSEFNKKQAQRSTQLTLLAAIYLPLTLATGIFGMNIQEINGGTPHWWVVFIVIAILFLPSASFVVMLFAGDDIKKTVQAMRDRKEREIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C7Y9</accession>
    <name>A0A177C7Y9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_938835</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG02969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033334.1">
        <property type="nucleotide sequence ID" value="XM_018187923.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C7Y9"/>
    <dbReference type="GeneID" id="28771409"/>
    <dbReference type="InParanoid" id="A0A177C7Y9"/>
    <dbReference type="OrthoDB" id="3800625at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG02969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="212" mass="24028" checksum="46A4C94EFA8119A8" modified="2016-09-07" version="1">MDGQETRRFLSQYSSTIGSYRQRLKEDLKYFKHTQMKLPPKTSSRPDFLVVPGPGEPSWLNILGGVDLVGVRSTESYDRGATKIQIRAKNPLVPHASRNGRRRNGESDRHMAHSLIVRQLAAMKGMNHARFLNILHWGRNRFTPLRIMKGGDIHGVSPPKYYFRNEFSSANECSIDNDTGDQTKSLSNCHEFLDDDVDPVLRKIGLLYSGNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C832</accession>
    <name>A0A177C832_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">Cutinase</fullName>
            <ecNumber evidence="3 12">3.1.1.74</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CC84DRAFT_1197370</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the hydrolysis of complex carboxylic polyesters found in the cell wall of plants. Degrades cutin, a macromolecule that forms the structure of the plant cuticle.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 12">
            <text>cutin + H2O = cutin monomers.</text>
            <dbReference type="EC" id="3.1.1.74"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the cutinase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.74" evidence="3 12"/>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG03715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034080.1">
        <property type="nucleotide sequence ID" value="XM_018181519.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C832"/>
    <dbReference type="STRING" id="1460663.A0A177C832"/>
    <dbReference type="GeneID" id="28765005"/>
    <dbReference type="InParanoid" id="A0A177C832"/>
    <dbReference type="OrthoDB" id="2975078at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050525">
        <property type="term" value="F:cutinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000675">
        <property type="entry name" value="Cutinase/axe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043580">
        <property type="entry name" value="CUTINASE_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011150">
        <property type="entry name" value="Cutinase_monf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48250:SF2">
        <property type="entry name" value="CUTINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48250">
        <property type="entry name" value="CUTINASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01083">
        <property type="entry name" value="Cutinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00129">
        <property type="entry name" value="CUTINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01110">
        <property type="entry name" value="Cutinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00155">
        <property type="entry name" value="CUTINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 12" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="active site" description="Nucleophile" evidence="10">
        <location>
            <position position="167"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="218"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="10">
        <location>
            <position position="230"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="82"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="214"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR611150-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR611150-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OAG03715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="250" mass="25650" checksum="4A18632CCFF1F552" modified="2016-09-07" version="1">MLCGCFYAVSPAALDSRADIPDALAKFPSGPLNQFLRLISSLPQGAAALDAVGKVLTPLQQGLADAVGIDTTKDDLAQSTSCADVTVVFARGTTEPGNVGLVTGPPFFDALKEQLGSKSLAVQGVEYPATFAGFNKNGTEGVPSMTAFINQALTTCPETKVVVSGYSQGALVVRGTAASLPADTMSRVSSVVTFGDPRNQTAITGAEGKTLTICYENDAVCSGGFITVDHLTYADNADEAAQFVVGKAQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C8K2</accession>
    <name>A0A177C8K2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1166920</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG03179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033544.1">
        <property type="nucleotide sequence ID" value="XM_018179082.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C8K2"/>
    <dbReference type="STRING" id="1460663.A0A177C8K2"/>
    <dbReference type="GeneID" id="28762568"/>
    <dbReference type="InParanoid" id="A0A177C8K2"/>
    <dbReference type="OrthoDB" id="5378435at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="257"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="165"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="277"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG03179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="361" mass="40756" checksum="BC74B67955C00BDF" modified="2016-09-07" version="1">MSNSLSPYDMATNMTAYAPNPYRTARSSNSQPGHPYRVEKPRSNHNSPRTVERRKTTTGAKLYATLDDHYNMMMGITSNEEIEPMGEPANTRPMSWHPSSNQYYTRPQSTMFDQSQDWSQTYSDQTSVQGSDFYSFSARNSMGADTTQQYPTYMTGYETHRGSQDSDSSWQTQQSQQSHVHSAYSTPATEPMPWYLQEWARKNQEQAASQNNSMDFLPIQHPTEPEEQQAGASMEDSGKELIGMGLYDVSDSSLDWTSPLGEATGKGLKLEETWQPPEEDEDEDDDDQDDNASSDDGEEELPPPPAPVAPVASAKDQPAGNMEGQSFFFDEDENISKEWWYQHLKQPSMPVRDAGYGYGWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C8W2</accession>
    <name>A0A177C8W2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CC84DRAFT_1149964</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG04083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034448.1">
        <property type="nucleotide sequence ID" value="XM_018176686.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C8W2"/>
    <dbReference type="STRING" id="1460663.A0A177C8W2"/>
    <dbReference type="GeneID" id="28760172"/>
    <dbReference type="InParanoid" id="A0A177C8W2"/>
    <dbReference type="OrthoDB" id="5141738at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000082">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF74">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="113"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="152"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="207"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="244"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="270"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="345"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="384"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="426"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="451"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="484"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="514"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="115"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="566"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="566"/>
            <end position="576"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAG04083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="594" mass="66073" checksum="65FABD1E5F1F5D67" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C9X0</accession>
    <name>A0A177C9X0_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CC84DRAFT_1123023</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG03629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033994.1">
        <property type="nucleotide sequence ID" value="XM_018175646.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C9X0"/>
    <dbReference type="STRING" id="1460663.A0A177C9X0"/>
    <dbReference type="GeneID" id="28759132"/>
    <dbReference type="InParanoid" id="A0A177C9X0"/>
    <dbReference type="OrthoDB" id="8117402at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000032">
        <property type="entry name" value="Krueppel-like factor 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235:SF120">
        <property type="entry name" value="KRUPPEL-LIKE FACTOR 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="345"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="375"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="69"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="438"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="554"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="78"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="97"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="138"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="438"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="448"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="465"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="564"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="591"/>
            <end position="603"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAG03629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="652" mass="71752" checksum="2B60C007FA71CD31" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2023-06-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CAG6</accession>
    <name>A0A177CAG6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_865884</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG03757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034122.1">
        <property type="nucleotide sequence ID" value="XM_018187705.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CAG6"/>
    <dbReference type="GeneID" id="28771191"/>
    <dbReference type="InParanoid" id="A0A177CAG6"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG03757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="106" mass="11889" checksum="B80E43B620D2DA39" modified="2016-09-07" version="1">MKLCALQCKQAVRSRWPICSLLCARRSRYLGWQEQSRAWCDFTFTALAVGGRMRVRCMSQLGPPALRSGLHLGRPTAQLNPTSHHLTTLAFIAARTTPRPMHPVST</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CAK9</accession>
    <name>A0A177CAK9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UBA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1218123</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG04693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035058.1">
        <property type="nucleotide sequence ID" value="XM_018182967.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CAK9"/>
    <dbReference type="STRING" id="1460663.A0A177CAK9"/>
    <dbReference type="GeneID" id="28766453"/>
    <dbReference type="InParanoid" id="A0A177CAK9"/>
    <dbReference type="OrthoDB" id="1717591at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031982">
        <property type="term" value="C:vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072318">
        <property type="term" value="P:clathrin coat disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072583">
        <property type="term" value="P:clathrin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000002">
        <property type="entry name" value="putative tyrosine-protein phosphatase auxilin isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000354">
        <property type="entry name" value="UBA domain-containing protein 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23172">
        <property type="entry name" value="AUXILIN/CYCLIN G-ASSOCIATED KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23172:SF19">
        <property type="entry name" value="J DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22562">
        <property type="entry name" value="UBA_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBA" evidence="2">
        <location>
            <begin position="303"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="347"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="437"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="788"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="41"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="82"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="348"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="396"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="515"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="545"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="597"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="624"/>
            <end position="638"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG04693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="944" mass="100782" checksum="F22238987174B429" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CAN5</accession>
    <name>A0A177CAN5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative endo-exoxylanase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CC84DRAFT_1147034</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 30 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG04436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034801.1">
        <property type="nucleotide sequence ID" value="XM_018176576.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CAN5"/>
    <dbReference type="STRING" id="1460663.A0A177CAN5"/>
    <dbReference type="GeneID" id="28760062"/>
    <dbReference type="InParanoid" id="A0A177CAN5"/>
    <dbReference type="OrthoDB" id="2012278at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004348">
        <property type="term" value="F:glucosylceramidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006680">
        <property type="term" value="P:glucosylceramide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049161">
        <property type="entry name" value="GH59_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001139">
        <property type="entry name" value="Glyco_hydro_30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11069">
        <property type="entry name" value="GLUCOSYLCERAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11069:SF23">
        <property type="entry name" value="LYSOSOMAL ACID GLUCOSYLCERAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02057">
        <property type="entry name" value="Glyco_hydro_59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0858">Xylan degradation</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008057904" evidence="4">
        <location>
            <begin position="18"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 59 catalytic" evidence="5">
        <location>
            <begin position="69"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAG04436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="484" mass="52559" checksum="A92DEF0489BC2004" modified="2016-09-07" version="1">MHLHVSIWSLVLPLSAASHSQRHISHDVAIPTVKIAINASTRFQVIDGFGVSEAFQRSAQVHGKAGLSESNQRKVLDYLFSNEVGAGLTSLRNGIGSSTSYIRDFMKSIEPTDPGGPNATAKYEWDGDDGSQVWLTKEALRYGVKWVYADAWSAPAYMKTNGNDSNGGSICGVQETFCASGDWRQAYANYLVQYIRFYKEKEGIAITHLGFLNEPDLNQTYASMQSSGFQAGDFLKVLAPTLKASGFEDVQIVCCEATGWNDGEDILAELQSIPGAEDSLAVYSAHGYSSNPALPFKTTISKTWQTEWADLDGSWRTSWDYLGKEGEGMAWANKIQQALTLSNVSGFLYWIGAETTTTNSALIRLANDTVSVSSRLWAFAQFSRFVKPGAVRVGVESGIGYVRVSAFENVNGGVVVNIINNGHVDVRTDVVISGWDGTVGNVTSWLTNNANNLTVGVEFRAIGGSREPGFNGLVPARSMVSYIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CB87</accession>
    <name>A0A177CB87_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nascent polypeptide-associated complex subunit alpha</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Alpha-NAC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CC84DRAFT_1206477</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NAC-alpha family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG04933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035298.1">
        <property type="nucleotide sequence ID" value="XM_018182032.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CB87"/>
    <dbReference type="FunCoup" id="A0A177CB87">
        <property type="interactions" value="546"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CB87"/>
    <dbReference type="GeneID" id="28765518"/>
    <dbReference type="InParanoid" id="A0A177CB87"/>
    <dbReference type="OrthoDB" id="3169036at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005854">
        <property type="term" value="C:nascent polypeptide-associated complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22054">
        <property type="entry name" value="NAC_NACA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14358">
        <property type="entry name" value="UBA_NAC_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.30:FF:000002">
        <property type="entry name" value="Nascent polypeptide-associated complex (NAC), alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000006">
        <property type="entry name" value="Putative nascent polypeptide-associated complex subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.30">
        <property type="entry name" value="Nascent polypeptide-associated complex domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016641">
        <property type="entry name" value="EGD2/NACA0like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044034">
        <property type="entry name" value="NAC-like_UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038187">
        <property type="entry name" value="NAC_A/B_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002715">
        <property type="entry name" value="Nas_poly-pep-assoc_cplx_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21713">
        <property type="entry name" value="NASCENT POLYPEPTIDE ASSOCIATED COMPLEX ALPHA SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01849">
        <property type="entry name" value="NAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19026">
        <property type="entry name" value="UBA_HYPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015901">
        <property type="entry name" value="NAC_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01407">
        <property type="entry name" value="NAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51151">
        <property type="entry name" value="NAC_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="NAC-A/B" evidence="8">
        <location>
            <begin position="49"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="117"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="20"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="117"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="128"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="152"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00030300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAG04933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="209" mass="22702" checksum="37D6158E9F224A86" modified="2016-09-07" version="1">MANPRIEELPDEVEKKNVEIEDGESDSDSEVEGEAESGVPAGASVTVHSRNEKKARKAIGKLGLKHIEGITRVTLRRPKGILFVINQPDVYKSPSSNTYIIFGEAKIEDLNSTAQANAAQQLAAQEAASHDHSGHDHEGHDHGKGKAVEAAKDEEEEEEDDDEEVDDSGLEAKDIELVMQQASVSRKKAVKALKENDNDIVNSIMALSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CCJ4</accession>
    <name>A0A177CCJ4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1176709</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG04498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034863.1">
        <property type="nucleotide sequence ID" value="XM_018180238.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CCJ4"/>
    <dbReference type="GeneID" id="28763724"/>
    <dbReference type="InParanoid" id="A0A177CCJ4"/>
    <dbReference type="OrthoDB" id="3497702at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008058024" evidence="1">
        <location>
            <begin position="19"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG04498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="125" mass="12774" checksum="E3FCF3C6B6F534C7" modified="2016-09-07" version="1">MQFTIATISALFAATSCALPAAQGATATVSFINDQTGAHAPVVAPLDGTVINLYNVLIGTPVGVPNQVIASSAQLIDYPQNVDCTINGINGGQLGQLNARQTYVLLKSGGINLDGATMMCTPLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CCM4</accession>
    <name>A0A177CCM4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1259900</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG04528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034893.1">
        <property type="nucleotide sequence ID" value="XM_018184946.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CCM4"/>
    <dbReference type="STRING" id="1460663.A0A177CCM4"/>
    <dbReference type="GeneID" id="28768432"/>
    <dbReference type="InParanoid" id="A0A177CCM4"/>
    <dbReference type="OrthoDB" id="5348404at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12432">
        <property type="entry name" value="RRM_ACINU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.30">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034257">
        <property type="entry name" value="Acinus_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032552">
        <property type="entry name" value="RSB_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003034">
        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036361">
        <property type="entry name" value="SAP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47031">
        <property type="entry name" value="SAP DNA-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47031:SF3">
        <property type="entry name" value="SAP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16294">
        <property type="entry name" value="RSB_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02037">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68906">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAP" evidence="2">
        <location>
            <begin position="3"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="299"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="539"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="579"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="129"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="214"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="539"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG04528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="615" mass="67509" checksum="547E656561DD7B07" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CD18</accession>
    <name>A0A177CD18_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RGS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1187945</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG05091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035456.1">
        <property type="nucleotide sequence ID" value="XM_018180965.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CD18"/>
    <dbReference type="STRING" id="1460663.A0A177CD18"/>
    <dbReference type="GeneID" id="28764451"/>
    <dbReference type="InParanoid" id="A0A177CD18"/>
    <dbReference type="OrthoDB" id="3232309at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39466">
        <property type="entry name" value="RGS DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39466:SF1">
        <property type="entry name" value="RGS DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="287"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="321"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="422"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG05091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="450" mass="50111" checksum="FA9654652D12E39C" modified="2016-09-07" version="1">MVYPINYRRPAHVSRAESSRGSLSGTDKQKSIEESVKSGSSGMSHGIPEALSFDRIISGGTCPPCTTRDFMNYLKYIELSAENLQFFLWFRSYAKRFNELPGNEKALSPEWFEDSETEAPARPKQLSPETAAVFKGTDFATDFRATEAEKSNPFFTPPRTPNSDLRREGGESLDSYDASLASGAKTDHAQRATGAFESAGLKWKPLSVQPYREEITRIISIYVADGGNRQLNLSSKERTALLHALQNTTHPSAFRDVIATVEWSLRCQAHPNFIRWTICNGNRPRVIFARGLGVGGIVGGFIAALLITLSSAGRAWRVLSLIGFMIGISTLIAAWKGMCVVLHGMHHRHLRPWELFASDDEPAASIDLKGDSFDSIISHASSNSYEDEPWVARYEKRNVVRKIFDREVWIQEPALRQIQDTIFLQAILGATVLSFIIVGIFCAVPHGNFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CD29</accession>
    <name>A0A177CD29_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DUF803-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CC84DRAFT_1091879</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG05563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035928.1">
        <property type="nucleotide sequence ID" value="XM_018174417.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CD29"/>
    <dbReference type="GeneID" id="28757903"/>
    <dbReference type="InParanoid" id="A0A177CD29"/>
    <dbReference type="OrthoDB" id="165382at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008521">
        <property type="entry name" value="Mg_trans_NIPA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570:SF65">
        <property type="entry name" value="MAGNESIUM TRANSPORTER NIPA9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05653">
        <property type="entry name" value="Mg_trans_NIPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="147"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="202"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="240"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="302"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="334"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="365"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="70"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="97"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAG05563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="391" mass="42182" checksum="BD62EB1F30A088CA" modified="2016-09-07" version="1" fragment="single">MLPPTSVAAGSATATSDAPTPTSTSIIPPYGSAQWNSLIGIITAIVGNVLISFALNTQRYAHIRLEREWQQKERQRKRRSASYRSLSGAKQYRDEPQGDDAANEEDPLLPASPRNSTGGSGSLSPVEEEGVLAEPAYKQKSYLKSPYWWAGIIMMTCGEAGNFLAYGFAPASIVSPLGVVALISNCIIAPFMLKEPFRARDALGVLVAVGGAVTVVLSASDNNPKLGPDEIWSLISTWEFETYFGITVGIIIALVFASNRYGDKNILIDLGLVGLFGGYTALSTKGVASMLSYTLWRAITFPVTYLLVAILVGTAIMQIKYINRALQRFDATQVIPVQFVLFTLSVILGSAILYRDFERTSADDAGKFVGGCALTFAGVWLITNGRPKRSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CE62</accession>
    <name>A0A177CE62_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1164018</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG05501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035866.1">
        <property type="nucleotide sequence ID" value="XM_018178394.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CE62"/>
    <dbReference type="GeneID" id="28761880"/>
    <dbReference type="InParanoid" id="A0A177CE62"/>
    <dbReference type="OrthoDB" id="3770443at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="47"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG05501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="147" mass="16242" checksum="EE8BB992E55079FB" modified="2016-09-07" version="1">MVVHLVNHTHRTEPPQKVYLKPELRPTNETLKHIHGVLASNSPEAGILFMMLEITLPILGVIAFLTLMLLIMRHVTNKLYPNNEEDSEAGDIELSSLGGTSVNSDGTLVNPRKLSKPGSPKAVDRFPDSKNGGVFAWRLAMEKPKQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CEW5</accession>
    <name>A0A177CEW5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Arylsulphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CC84DRAFT_1186979</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="PTM">
        <text evidence="5">The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfatase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG05856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036221.1">
        <property type="nucleotide sequence ID" value="XM_018180895.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CEW5"/>
    <dbReference type="STRING" id="1460663.A0A177CEW5"/>
    <dbReference type="GeneID" id="28764381"/>
    <dbReference type="InParanoid" id="A0A177CEW5"/>
    <dbReference type="OrthoDB" id="96314at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004065">
        <property type="term" value="F:arylsulfatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005539">
        <property type="term" value="F:glycosaminoglycan binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008449">
        <property type="term" value="F:N-acetylglucosamine-6-sulfatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018958">
        <property type="term" value="P:phenol-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16147">
        <property type="entry name" value="G6S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.720.10:FF:000051">
        <property type="entry name" value="Arylsulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012083">
        <property type="entry name" value="Arylsulfatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024607">
        <property type="entry name" value="Sulfatase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43108">
        <property type="entry name" value="N-ACETYLGLUCOSAMINE-6-SULFATASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43108:SF8">
        <property type="entry name" value="SD21168P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000972">
        <property type="entry name" value="Arylsulf_plant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00523">
        <property type="entry name" value="SULFATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Sulfatase N-terminal" evidence="6">
        <location>
            <begin position="19"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="modified residue" description="3-oxoalanine (Cys)" evidence="5">
        <location>
            <position position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000972-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAG05856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="554" mass="62086" checksum="7FD810FADF6F328C" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CFD3</accession>
    <name>A0A177CFD3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1244090</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG05652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036017.1">
        <property type="nucleotide sequence ID" value="XM_018184140.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CFD3"/>
    <dbReference type="STRING" id="1460663.A0A177CFD3"/>
    <dbReference type="GeneID" id="28767626"/>
    <dbReference type="InParanoid" id="A0A177CFD3"/>
    <dbReference type="OrthoDB" id="3784817at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008058211" evidence="2">
        <location>
            <begin position="23"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="104"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG05652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="508" mass="57048" checksum="B2E4553EB845314B" modified="2016-09-07" version="1">MHLNKASIFSVCLLALRIGVAAAPTENINTALIVDQDHNTTSVADGHLPLGNTGIEFPVPVAGLERRKAKGSSKGTSRKPSKTTKKKRPTKPKPANSKVTSKAKLSPTKSKSVSKSASKTKSAKDPYGSCKPKKGAKGTKGTKTKGKKGVKREEEGFTPISDEQYHSLAARDRKILQAGAVELQFPTHPSSGDAIRVKRYKADGMKAYGTVNPDPCDDDYALKVVTYPTAQGQGLIGENWDTEHVMDAQIIQQFFEYLNDNLPTTNMPAQWWSRDSQTGKIGHFQVQRAFRYMRDFWEDRKGTGGITATDHLLAVYPGTHQYTGELTLLGHGINRKKESIFGHGGGSCIGSSTWRGLDYWGKVDKLRECVLLAKYMNHADIQDSFEAVATRIKKRLTKMEDVGGFMESTDDYWARKMNNNKYLDRQGEVYKDQRLDRYWQQWLKQFMATRLSNLSTEITTKLRELDTIQKGAQKDRNLSQQRRDRIASRYRRIDRAWTATKPLRNPAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CFD4</accession>
    <name>A0A177CFD4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1090801</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG06323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036688.1">
        <property type="nucleotide sequence ID" value="XM_018174377.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CFD4"/>
    <dbReference type="GeneID" id="28757863"/>
    <dbReference type="InParanoid" id="A0A177CFD4"/>
    <dbReference type="OrthoDB" id="5386682at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF73">
        <property type="entry name" value="HET DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_8G01020)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="17"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG06323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="108" mass="12955" checksum="330CFC79BFC6621D" modified="2016-09-07" version="1" fragment="single">MSHTEDWDNDKKAATKYTCLSYRWGDDEATHTVLINGKIRCVRQNLFDFLDMWKHGRRRRRKLKRWFWIDALCIDQTNAAERNHQVQKMGQIYSNAEEVIVWLGKEPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CG07</accession>
    <name>A0A177CG07_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative 14-3-3 family protein ArtA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CC84DRAFT_1092414</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the 14-3-3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG05892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036257.1">
        <property type="nucleotide sequence ID" value="XM_018174451.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CG07"/>
    <dbReference type="FunCoup" id="A0A177CG07">
        <property type="interactions" value="1362"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CG07"/>
    <dbReference type="GeneID" id="28757937"/>
    <dbReference type="InParanoid" id="A0A177CG07"/>
    <dbReference type="OrthoDB" id="10260625at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.190.20:FF:000002">
        <property type="entry name" value="14-3-3 protein epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.190.20">
        <property type="entry name" value="14-3-3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000308">
        <property type="entry name" value="14-3-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023409">
        <property type="entry name" value="14-3-3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036815">
        <property type="entry name" value="14-3-3_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023410">
        <property type="entry name" value="14-3-3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18860">
        <property type="entry name" value="14-3-3 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00244">
        <property type="entry name" value="14-3-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000868">
        <property type="entry name" value="14-3-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00305">
        <property type="entry name" value="1433ZETA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00101">
        <property type="entry name" value="14_3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48445">
        <property type="entry name" value="14-3-3 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00796">
        <property type="entry name" value="1433_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00797">
        <property type="entry name" value="1433_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="14-3-3" evidence="5">
        <location>
            <begin position="4"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="233"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="233"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="258"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with phosphoserine on interacting protein" evidence="2">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with phosphoserine on interacting protein" evidence="2">
        <location>
            <position position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000868-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAG05892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="269" mass="29623" checksum="0C88C82145933285" modified="2016-09-07" version="1">MGYEDSVYLAKLAEQAERYEEMVENMKAVASADQELSVEERNLLSVAYKNVIGARRASWRIVTSIEQKEESKGNETQVGLIKEYRQKIEAELAQICEDILACLDEHLIPSAESGESKVFYHKMKGDYHRYLAEFAVGDKRKTSADKSLEAYKAATEVAASSLAPTHPIRLGLALNFSVFYYEILNSPDQACQLAKQAFDDAIAELDTLSEESYKDSTLIMQLLRDNLTLWTSSEAEAPAESTPADAPAAADATKEEPAAPAAAAEEPKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CG13</accession>
    <name>A0A177CG13_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1175871</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG05748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036113.1">
        <property type="nucleotide sequence ID" value="XM_018180176.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CG13"/>
    <dbReference type="GeneID" id="28763662"/>
    <dbReference type="InParanoid" id="A0A177CG13"/>
    <dbReference type="OrthoDB" id="3889136at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG05748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="162" mass="17224" checksum="3B8489F780CDFC93" modified="2016-09-07" version="1">MPPKKVVATKGDAGDDGDKFSWTAENERKLLLFMIGTTSFTKEDTERLAEHAFNGGLLTTPPTSTTLICNTGPSANAIKQRANKIRIEHRALYEEHGWPAPDGKPAVKAATPKTKKRGAADGTDDAPATPSKKGKKGKAAEDGDGPSNDLDRGIKAEAVEEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CG55</accession>
    <name>A0A177CG55_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NB-ARC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1052555</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG05932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036297.1">
        <property type="nucleotide sequence ID" value="XM_018173496.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CG55"/>
    <dbReference type="STRING" id="1460663.A0A177CG55"/>
    <dbReference type="GeneID" id="28756982"/>
    <dbReference type="InParanoid" id="A0A177CG55"/>
    <dbReference type="OrthoDB" id="20872at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
        <property type="entry name" value="NB-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NB-ARC" evidence="1">
        <location>
            <begin position="18"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG05932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="125" mass="14227" checksum="27E4C75949986EC5" modified="2016-09-07" version="1" fragment="single">SYTIPFRRDPDFVDRGTLLDELKEKCSAPASRVALVGIGGVGKSQLAIEHCYRTHETSLGMWVLWAHASSTARLEQSFHDIADRVKIEGRRDPQVNIFKLVHDWMCDTDERWLLVLDNVDDAGFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CG68</accession>
    <name>A0A177CG68_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1162953</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG06593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036958.1">
        <property type="nucleotide sequence ID" value="XM_018178134.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CG68"/>
    <dbReference type="GeneID" id="28761620"/>
    <dbReference type="InParanoid" id="A0A177CG68"/>
    <dbReference type="OrthoDB" id="3789817at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="275"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="405"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="406"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG06593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="520" mass="58266" checksum="A62644F4D43F2272" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CGC3</accession>
    <name>A0A177CGC3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CC84DRAFT_1092620</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG05992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036357.1">
        <property type="nucleotide sequence ID" value="XM_018174472.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CGC3"/>
    <dbReference type="STRING" id="1460663.A0A177CGC3"/>
    <dbReference type="GeneID" id="28757958"/>
    <dbReference type="InParanoid" id="A0A177CGC3"/>
    <dbReference type="OrthoDB" id="3936150at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015606">
        <property type="term" value="F:spermidine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000297">
        <property type="term" value="F:spermine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF38">
        <property type="entry name" value="POLYAMINE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="14"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="82"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="106"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="16"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAG05992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="139" mass="15030" checksum="4511AB9537E90F0A" modified="2016-09-07" version="1" fragment="single">DPLNPHKWSLVRRWFQACTVSGIAFAGTFVSSVFTPAMEKSATDLRSSIIMGSLAYLIHPIGLTLGSPFAAPFNETFGRKPILLINLPIFALFVLGIGFAHSMVTFVVLCFSTGIFAALSLIIGPGILSDQWQPEMIKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CGL1</accession>
    <name>A0A177CGL1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1217197</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG05900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036265.1">
        <property type="nucleotide sequence ID" value="XM_018182873.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CGL1"/>
    <dbReference type="GeneID" id="28766359"/>
    <dbReference type="InParanoid" id="A0A177CGL1"/>
    <dbReference type="OrthoDB" id="4764520at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008058151" evidence="1">
        <location>
            <begin position="17"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG05900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="105" mass="11557" checksum="25477A026818D9CE" modified="2016-09-07" version="1" fragment="single">MHFRNVVLLIPALVAAAPVAEPKALVPVSPWTPALNLRTLDEDAAKYGKRALDEDAAKYGKRTLDEDAAKYGRRELDEDAAKYGKRTLDEDAAKYGKRTLDEDAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CGW8</accession>
    <name>A0A177CGW8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CC84DRAFT_1091515</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG06192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036557.1">
        <property type="nucleotide sequence ID" value="XM_018174403.1"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CGW8"/>
    <dbReference type="GeneID" id="28757889"/>
    <dbReference type="InParanoid" id="A0A177CGW8"/>
    <dbReference type="OrthoDB" id="2913095at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031350">
        <property type="entry name" value="Goodbye_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF17">
        <property type="entry name" value="FUNGAL STAND N-TERMINAL GOODBYE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17109">
        <property type="entry name" value="Goodbye"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="Fungal STAND N-terminal Goodbye" evidence="4">
        <location>
            <begin position="12"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="5">
        <location>
            <begin position="287"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="2">
        <location>
            <begin position="925"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="360"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1304"/>
            <end position="1363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="360"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1344"/>
            <end position="1353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAG06192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="1486" mass="167688" checksum="FC3B231ABA3D65F5" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CGZ0</accession>
    <name>A0A177CGZ0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Spindle pole body interacting protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1185973</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG06835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037200.1">
        <property type="nucleotide sequence ID" value="XM_018180833.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CGZ0"/>
    <dbReference type="FunCoup" id="A0A177CGZ0">
        <property type="interactions" value="6"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CGZ0"/>
    <dbReference type="GeneID" id="28764319"/>
    <dbReference type="InParanoid" id="A0A177CGZ0"/>
    <dbReference type="OrthoDB" id="66409at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051666">
        <property type="term" value="P:actin cortical patch localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052809">
        <property type="entry name" value="Actin_polarity_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012860">
        <property type="entry name" value="Afi1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037516">
        <property type="entry name" value="Tripartite_DENN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28245">
        <property type="entry name" value="ARF3-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28245:SF1">
        <property type="entry name" value="ARF3-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07792">
        <property type="entry name" value="Afi1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08616">
        <property type="entry name" value="SPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50211">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDENN" evidence="2">
        <location>
            <begin position="95"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="316"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="689"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="22"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="697"/>
            <end position="712"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG06835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="803" mass="89928" checksum="11F0E7FA250D62DB" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CH74</accession>
    <name>A0A177CH74_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1164523</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG06208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036573.1">
        <property type="nucleotide sequence ID" value="XM_018178503.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CH74"/>
    <dbReference type="STRING" id="1460663.A0A177CH74"/>
    <dbReference type="GeneID" id="28761989"/>
    <dbReference type="InParanoid" id="A0A177CH74"/>
    <dbReference type="OrthoDB" id="4521980at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG06208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="139" mass="15982" checksum="8FE761F88EB57CFC" modified="2016-09-07" version="1">MREIPARTPTYHPIKDPATAEWGLAIKRTDYEKLLEGFRPRDMDDKWLCITEKNDAQGNTTVHWYRSWGNMEYYTVIVEVQDPKQAKENDWAKLTKITWEKLVGGLEVPVEEAKGDVVDLCRAFVGCEFENAGSASRSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CIF0</accession>
    <name>A0A177CIF0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1186291</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG07283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037648.1">
        <property type="nucleotide sequence ID" value="XM_018180849.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CIF0"/>
    <dbReference type="STRING" id="1460663.A0A177CIF0"/>
    <dbReference type="GeneID" id="28764335"/>
    <dbReference type="InParanoid" id="A0A177CIF0"/>
    <dbReference type="OrthoDB" id="3912356at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG07283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="309" mass="35296" checksum="0FEEC17F401A16CF" modified="2016-09-07" version="1">MDKKLPNHLFCFPCAKWHVRTTPGLEKLKPPRVLNPVYDCPNSTNNLMPPPRLRICDSRWLPFTFVQLYKRAWEHGPGYGINVHSLARRFKDVELGWSHETMFHIHPANGHVLMRVKSQVFVEGGMQPAAKRLLLFTRSDYTPYFSVCAHWRKGLLTSIPKCALDHIPTPEENVYMATFNKMRHAKLVGPTALCGHCQPMRRCAECPTEYLFELKLVEDKTVQKMSPERFRQVLLVTRWSDLGPARSPRDPEWASVVGEGDGYDSFREIGKRAVSGIFESAFTDTTPRARILSLNPAGLQDGGDDGDWY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CJ22</accession>
    <name>A0A177CJ22_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Eukaryotic translation initiation factor 3 subunit F</fullName>
            <shortName evidence="4">eIF3f</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CC84DRAFT_1186310</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the eIF-3 subunit F family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG07316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037681.1">
        <property type="nucleotide sequence ID" value="XM_018180851.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CJ22"/>
    <dbReference type="STRING" id="1460663.A0A177CJ22"/>
    <dbReference type="GeneID" id="28764337"/>
    <dbReference type="InParanoid" id="A0A177CJ22"/>
    <dbReference type="OrthoDB" id="25498at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071540">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex, eIF3e"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071541">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex, eIF3m"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd08064">
        <property type="entry name" value="MPN_eIF3f"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000019">
        <property type="entry name" value="Eukaryotic translation initiation factor 3 subunit F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03005">
        <property type="entry name" value="eIF3f"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027531">
        <property type="entry name" value="eIF3f"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024969">
        <property type="entry name" value="EIF3F/CSN6-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10540:SF6">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10540">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13012">
        <property type="entry name" value="MitMem_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4 7" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MPN" evidence="6">
        <location>
            <begin position="30"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="310"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="331"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAG07316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="348" mass="37969" checksum="556DF5F2E7AC14B0" modified="2016-09-07" version="1">MADKESFLHLARPLGPAPLGAQPSTAPLNVVVQPQAIFSILDHALRRPADQERVIGTLLGTRSEDGTEVEIRNCYAVPHTETAEQVEVDMDYQKQMLQLHLRANPREVLVGWYATSSDLNTFSALIQNFYGQQGDGTWPHPAVHLTVSTDPGQEIESRTYISAPIGVTAERAADSCLFIPVPHELKYGEAEKSGLELISSAKDREDRSQPIITDLEALERAITHVLEMLDRVSTYVNNVLDEEAEPSSALGQYLMNALSLAPKVDAQDIERDFNNHIQDVLVVSYLANTIRTQIDLSNRLATAALTLGTGDAITGDGEQQGGRGGDRQRGGRGGRGGGQGRQQRQQEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2023-06-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CJA8</accession>
    <name>A0A177CJA8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1163310</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG07062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037427.1">
        <property type="nucleotide sequence ID" value="XM_018178232.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CJA8"/>
    <dbReference type="GeneID" id="28761718"/>
    <dbReference type="InParanoid" id="A0A177CJA8"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG07062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="211" mass="24522" checksum="44ED6C17E3513F36" modified="2016-09-07" version="1">MDTSVGNLSREHTKGAANPKHRIRPRIVLAYDSVRRKQPVRRRCASRMLTGGAIHRMFRRVGLEKAMLWAAIETRDPEPWESPWAVSGGCDCHDSCVNYYLHRTVQYAQRKWWLGGETVPADFALEDQTRHSRNSRCSRQITWIVECHPSIYDSFLRLLLRHRQLMLQVTGPRIDGKCRVVGLEHNALLEKIILQILRDSMKQRRQVAVLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CJK4</accession>
    <name>A0A177CJK4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1174903</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG07019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037384.1">
        <property type="nucleotide sequence ID" value="XM_018180120.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CJK4"/>
    <dbReference type="GeneID" id="28763606"/>
    <dbReference type="InParanoid" id="A0A177CJK4"/>
    <dbReference type="OrthoDB" id="3784745at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="299"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG07019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="365" mass="39522" checksum="F850848685649D1B" modified="2016-09-07" version="1">MSSPTTHDLIDVSEFNSNLADISSAASHEVQSQAGPSDANAPLRAPTGPKFTSGYSHGHRVMRNPPCPFSGIPSPQTMHRHILHKKEDKKCLSITLMQPPAMPWSPLPSNQNMETRTCFYTGSRVHKLDCGHTVVVARDAEPCAANCKPPMCMISSTSSALPAPYAAPINLVRASTLRILQSHVEFLVDAGDALAQAKFAAHAEILSKVWDAQDKTLAPPKDLISGNFSCALCGTVGMRASRAAAVVKGAPYHCVLVGNDTCDVAIIMELEKGVQPSASSPFGSFNGNLRNQNKVPPLKRLGVANDRGHRRSSAIAGERESAGDVRRRKKDAWQSVVRRREKEVVMGKLREECLMEKLGGMELER</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CK21</accession>
    <name>A0A177CK21_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_1256840</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG07874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038239.1">
        <property type="nucleotide sequence ID" value="XM_018184670.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CK21"/>
    <dbReference type="STRING" id="1460663.A0A177CK21"/>
    <dbReference type="GeneID" id="28768156"/>
    <dbReference type="InParanoid" id="A0A177CK21"/>
    <dbReference type="OrthoDB" id="4941332at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008058266" evidence="3">
        <location>
            <begin position="20"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="125"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="208"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="248"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="347"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAG07874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="420" mass="45918" checksum="9EBB807F1A1EC22E" modified="2016-09-07" version="1">MSGIKITGLVLGTITTVTATISQSVESLTGLKSIIRNAYRDRVAQFEEYGVAAFFLDTMFPDAPRIMRRVERYILNADDQQVVAFMKQYTSSFNMTGVAGAIISQVAITALSLMRLQDTHWTAEAFFITSLVTGALSVYFSTALSPAFNGLHSADDIKDFLTKPAKWRNLTRLNNHLRHAEQTQSLTSGLSRKLPQLIAEERWKVPSAYAAIMLVVPMTLLNVALNTFLIGLGIYLGKLYTAELVPSYGSGSLGILIVYIATALFGIGIFYTPQISKAIEDIPFERYRSIVHANKLKMSESGQGTPDVNGTEEAPIAPQNSLQSVHARKKGNKVGYEIIELSESEMVASPDPLEDTDAPDEGYIKPPPSSSETELLSHVAESVSSDNAPNVQDALRALIEAQEISLRASRILLEALNRSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CK77</accession>
    <name>A0A177CK77_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_655723</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG07372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037737.1">
        <property type="nucleotide sequence ID" value="XM_018187028.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CK77"/>
    <dbReference type="GeneID" id="28770514"/>
    <dbReference type="InParanoid" id="A0A177CK77"/>
    <dbReference type="OrthoDB" id="10409843at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG07372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="187" mass="21511" checksum="DEC65B5B668E7800" modified="2016-09-07" version="1">MTPMAAYAHALESPALRVVWRWPRLSKRFVPNSGIVFFLQLFHHSLLDLTICSQLCMKTISPVVSFFEYTQFLHHFLFTGIPFSVIRICMPLGKWPSEEVDLRPLIVARTVDTNDDPMNSIIELQGGYLERLFSDSAVWKKVLSSGQIRAISFRSERWKAYLTFTISNHLGDEWHQYGHGAVAHECP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CKJ3</accession>
    <name>A0A177CKJ3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="10">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CC84DRAFT_1088485</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>feruloyl-polysaccharide + H2O = ferulate + polysaccharide.</text>
            <dbReference type="EC" id="3.1.1.73"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the tannase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="10"/>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG07360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037725.1">
        <property type="nucleotide sequence ID" value="XM_018174256.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CKJ3"/>
    <dbReference type="GeneID" id="28757742"/>
    <dbReference type="InParanoid" id="A0A177CKJ3"/>
    <dbReference type="OrthoDB" id="3039123at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030600">
        <property type="term" value="F:feruloyl esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011118">
        <property type="entry name" value="Tannase/feruloyl_esterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33938">
        <property type="entry name" value="FERULOYL ESTERASE B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33938:SF15">
        <property type="entry name" value="FERULOYL ESTERASE B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07519">
        <property type="entry name" value="Tannase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="5 10" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0858">Xylan degradation</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007948960" description="Carboxylic ester hydrolase" evidence="10">
        <location>
            <begin position="21"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OAG07360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="508" mass="55172" checksum="DF048127E60ADAF5" modified="2016-09-07" version="1">MARLCRLATFLLVQAAVAVAAPAHISSHCAKLRSLSLEQFNASIVNATYHAANAFNVSETFNDIPFCEVQAQVPYGKNNSLSFVVWLPDECDYQQRFLAVGNGGFAGTIDTVSMLKQLNAGLGLVVAGGNGGHEATGNTGDGFLPFMHDPGQIRAWIHDGISLFTSAAKEVVLAYYGKAAKKSYYAGCSTGGAQGYALAQYHPHLFDGIYAGSPGFWYSHLMLSFLWNLQKTNVGGTSLRKPQLNFTAQAVLDTCDTLDGVQDGLIENPLLCNFDIDSLVCGGSSEPDRCLSPDQIEAAKGIYAGPRRADNGEILYPGFSFGSEREWLLQEGSLGNEYAVPVLRNMVFDDLNWDPSTFDWSTDVDLVGSRASVLIDEISANLTSYRRTGGKFLTSQGWSDSYNAGELPVSHLEDIQALLGGDISDFYRLFMIPGGGHCGAAQYSPEVPAEYHYLGPLIEWVEAGTPPAQLLSSDPPDKSNRTRKLCPWPQTAHLVGENVNDWKNYRCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CL72</accession>
    <name>A0A177CL72_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_702395</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG07618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037983.1">
        <property type="nucleotide sequence ID" value="XM_018187101.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CL72"/>
    <dbReference type="GeneID" id="28770587"/>
    <dbReference type="InParanoid" id="A0A177CL72"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG07618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="181" mass="19991" checksum="63640A7C7698E0F6" modified="2016-09-07" version="1">MRSTTAFTPAIDVPACERPRTAVSAPSSARYKDTRSQSSFHTIDSNGRDATLRAKPTVPHSSPFFIPSLSLTTTHAVTHGTHLPQRHPKRTVPSFSPHCPRPAYAYAANQTNPPTHTHTHTHTHTHTHTHTHTHKKQHPPSHRHHTVATPTPPTHGANETTNAPSASHGWAFPFRVEWVCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CM07</accession>
    <name>A0A177CM07_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1161943</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG07898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038263.1">
        <property type="nucleotide sequence ID" value="XM_018177866.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CM07"/>
    <dbReference type="STRING" id="1460663.A0A177CM07"/>
    <dbReference type="GeneID" id="28761352"/>
    <dbReference type="InParanoid" id="A0A177CM07"/>
    <dbReference type="OrthoDB" id="6058203at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG07898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="269" mass="29952" checksum="2C085B9E5CA26A8A" modified="2016-09-07" version="1">MNAATWAHTMFSKEQTSLPAGVAGVTTSRRGIYLTQRHLHRPWNPTLSQHEPCTNAVLKLFISRDKYHIAPGGPALQGAYVVRMLHTSVDACKPFDPLVTNTTSYHRYVARLADTPCFDNLPSIGLKVAVSPRAHRIALAAWRTLKIYALNPQVFLSQDQGLYGPEQSDDGNAFTYCDPCPTSAWRSGYYNNWTREEEHVLLEPVTMPSTGVVHALRWVSEDEVWAVTDEGVCRWNVGVWATGERTEDYLAHCSGDLGLKRVKKGSVGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CN99</accession>
    <name>A0A177CN99_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial division protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CC84DRAFT_1240275</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in mitochondrial fission. Acts as an adapter protein required to form mitochondrial fission complexes. Formation of these complexes is required to promote constriction and fission of the mitochondrial compartment at a late step in mitochondrial division.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat MDV1/CAF4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039131.1">
        <property type="nucleotide sequence ID" value="XM_018184012.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CN99"/>
    <dbReference type="STRING" id="1460663.A0A177CN99"/>
    <dbReference type="GeneID" id="28767498"/>
    <dbReference type="InParanoid" id="A0A177CN99"/>
    <dbReference type="OrthoDB" id="5421599at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990234">
        <property type="term" value="C:transferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847:SF637">
        <property type="entry name" value="WD REPEAT DOMAIN 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="301"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00039789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00043913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAG08766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="370" mass="41926" checksum="10FECB00FFA31859" modified="2016-09-07" version="1">MSTAYPRRYCRAQQYRTNISTRPVAAPRSPSAVAAAQARALVQSASGLFIWAATACRFICEGRHFVARRLETILRDNSNNTRALEKHLDQIYTTMLMLWHVLRSMLLSKLLRCAGEEARQALEDLHAIINIPEGPAQPLCLYHPSFRDFLLDRQRCNDDNFWVNERRIHEKLVAYCVELMSAPYGLRQDIYKLSKPGIRRIEIDESRITASLPPELQYAQRGIKDGDATHGFLEKHLLYWLKAMSLMNETSLCVRLIYVSALLFSPEASIVRKIFIEEVQPQAVRVLSERDIEWDACRSVLEGHLEGVSAVVFSPDGQLVASASEDSTVRVWETATGQCRSVLYGRPSIFHIAFSPNGQTLQTNTGAWCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CNA2</accession>
    <name>A0A177CNA2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1215437</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039349.1">
        <property type="nucleotide sequence ID" value="XM_018182721.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CNA2"/>
    <dbReference type="GeneID" id="28766207"/>
    <dbReference type="InParanoid" id="A0A177CNA2"/>
    <dbReference type="OrthoDB" id="3749299at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG08984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="322" mass="35645" checksum="FD6FC6BE0FE89BE9" modified="2016-09-07" version="1">MSQPNAMLALFLDGNLSFQLTREGFAGSKPRLMIQMHDTSSAATIIIPGYQPSMKGFSLAFALQGGLLDLFDAGSNSKIPVPSNNAQPGELVVRAGAPSQWFNLRFDPCEDFGQGPPEQVPVRFLPRPIKLNVFDEATAPPQFSLSLTPTNKICHLSGEPRFGFKLEFMSHINEVITVCLYKTPLRELHGLEDVAIVEDEGGEEVEWPWGIGCWEGPEPFPSDDNFEELKPGVPYKTTFWLDKFDTRTSTGGELESLQARTRYTGMVSDDLRSGFGNWRRGNKEKLLAGDVKEKEERWKSGSGCSAQSIIEVSDPFTFETAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CNC0</accession>
    <name>A0A177CNC0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF1294-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1162581</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039066.1">
        <property type="nucleotide sequence ID" value="XM_018178027.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CNC0"/>
    <dbReference type="GeneID" id="28761513"/>
    <dbReference type="InParanoid" id="A0A177CNC0"/>
    <dbReference type="OrthoDB" id="10259680at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010718">
        <property type="entry name" value="DUF1294"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06961">
        <property type="entry name" value="DUF1294"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG08701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="133" mass="15411" checksum="3B5C94CCD01579E8" modified="2016-09-07" version="1">MPPRTRSHHRHRPITPLTFLAASSLILPILSLTRLYLRAHAILLTIFTVVLSLVTFLLYGYDKMQARNLNWRVKESTLHLCAVLGGWPGALAGMHYFQHKTRKVRFLIVFWGIVACWEGVWLGIWRADYGDWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CNW6</accession>
    <name>A0A177CNW6_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">aminodeoxychorismate synthase</fullName>
            <ecNumber evidence="4">2.6.1.85</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Para-aminobenzoate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">p-aminobenzoic acid synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CC84DRAFT_1194641</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>chorismate + L-glutamine = 4-amino-4-deoxychorismate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:11672"/>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58406"/>
            <dbReference type="EC" id="2.6.1.85"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 4-aminobenzoate from chorismate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the anthranilate synthase component I family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.85" evidence="4"/>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038822.1">
        <property type="nucleotide sequence ID" value="XM_018181356.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CNW6"/>
    <dbReference type="FunCoup" id="A0A177CNW6">
        <property type="interactions" value="179"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CNW6"/>
    <dbReference type="GeneID" id="28764842"/>
    <dbReference type="InParanoid" id="A0A177CNW6"/>
    <dbReference type="OrthoDB" id="64220at2759"/>
    <dbReference type="UniPathway" id="UPA00077">
        <property type="reaction ID" value="UER00149"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046820">
        <property type="term" value="F:4-amino-4-deoxychorismate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008153">
        <property type="term" value="P:4-aminobenzoate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046656">
        <property type="term" value="P:folic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:L-tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01743">
        <property type="entry name" value="GATase1_Anthranilate_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.120.10">
        <property type="entry name" value="Anthranilate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005801">
        <property type="entry name" value="ADC_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019999">
        <property type="entry name" value="Anth_synth_I-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006805">
        <property type="entry name" value="Anth_synth_I_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015890">
        <property type="entry name" value="Chorismate_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010117">
        <property type="entry name" value="PabB_fungal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006221">
        <property type="entry name" value="TrpG/PapA_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01823">
        <property type="entry name" value="PabB-fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11236">
        <property type="entry name" value="AMINOBENZOATE/ANTHRANILATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11236:SF18">
        <property type="entry name" value="AMINODEOXYCHORISMATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04715">
        <property type="entry name" value="Anth_synt_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00425">
        <property type="entry name" value="Chorismate_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00097">
        <property type="entry name" value="ANTSNTHASEII"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00099">
        <property type="entry name" value="CPSGATASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00096">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56322">
        <property type="entry name" value="ADC synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0289">Folate biosynthesis</keyword>
    <keyword evidence="7" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glutamine amidotransferase" evidence="10">
        <location>
            <begin position="23"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="Anthranilate synthase component I N-terminal" evidence="12">
        <location>
            <begin position="321"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="domain" description="Chorismate-utilising enzyme C-terminal" evidence="11">
        <location>
            <begin position="533"/>
            <end position="805"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF04715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OAG08457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="816" mass="90632" checksum="5AD286798DF6BE93" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CNX5</accession>
    <name>A0A177CNX5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1203950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038983.1">
        <property type="nucleotide sequence ID" value="XM_018181866.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CNX5"/>
    <dbReference type="GeneID" id="28765352"/>
    <dbReference type="InParanoid" id="A0A177CNX5"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG08618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="181" mass="19945" checksum="A9BE6677D808114D" modified="2016-09-07" version="1">MEVQPSSTRPNGGAVASRAFSRYSAVFSFIRPRFKKTMTDVQISVSKYTKPPCRYPRRAPEPSPLSPDTGTATVPDNTPIMREVEVCGDSCHDVSRFCLFARSALSSDIVSTLLCVRYQTLLLAHFKIISQHEGLPVDVLFSACFHARLRGHEEIAAYTLSDVFVTVVVLGQSVLECTSQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CPZ6</accession>
    <name>A0A177CPZ6_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_600020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG09012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039377.1">
        <property type="nucleotide sequence ID" value="XM_018186835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CPZ6"/>
    <dbReference type="STRING" id="1460663.A0A177CPZ6"/>
    <dbReference type="GeneID" id="28770321"/>
    <dbReference type="InParanoid" id="A0A177CPZ6"/>
    <dbReference type="OrthoDB" id="342064at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025239">
        <property type="entry name" value="DUF4187"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039249">
        <property type="entry name" value="GPATCH11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007042">
        <property type="entry name" value="SERRATE/Ars2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021933">
        <property type="entry name" value="SERRATE/Ars2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21032">
        <property type="entry name" value="G PATCH DOMAIN-CONTAINING PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21032:SF2">
        <property type="entry name" value="RESISTANCE PROTEIN ARS2, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G14710)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04959">
        <property type="entry name" value="ARS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13821">
        <property type="entry name" value="DUF4187"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12066">
        <property type="entry name" value="SERRATE_Ars2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01173">
        <property type="entry name" value="DUF4187"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="656"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="334"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="452"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="564"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="762"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="472"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="808"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="840"/>
            <end position="849"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG09012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="849" mass="96238" checksum="123BAA43EDA07824" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CQF3</accession>
    <name>A0A177CQF3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">rhamnogalacturonan endolyase</fullName>
            <ecNumber evidence="4">4.2.2.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CC84DRAFT_599920</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endotype eliminative cleavage of L-alpha-rhamnopyranosyl-(1-&gt;4)-alpha-D-galactopyranosyluronic acid bonds of rhamnogalacturonan I domains in ramified hairy regions of pectin leaving L-rhamnopyranose at the reducing end and 4-deoxy-4,5-unsaturated D-galactopyranosyluronic acid at the non-reducing end.</text>
            <dbReference type="EC" id="4.2.2.23"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the polysaccharide lyase 4 family.</text>
    </comment>
    <dbReference type="EC" id="4.2.2.23" evidence="4"/>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG09009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039374.1">
        <property type="nucleotide sequence ID" value="XM_018186833.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CQF3"/>
    <dbReference type="STRING" id="1460663.A0A177CQF3"/>
    <dbReference type="GeneID" id="28770319"/>
    <dbReference type="InParanoid" id="A0A177CQF3"/>
    <dbReference type="OrthoDB" id="114708at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102210">
        <property type="term" value="F:rhamnogalacturonan endolyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045490">
        <property type="term" value="P:pectin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10317">
        <property type="entry name" value="RGL4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10316">
        <property type="entry name" value="RGL4_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1120">
        <property type="entry name" value="Carboxypeptidase-like, regulatory domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013784">
        <property type="entry name" value="Carb-bd-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029413">
        <property type="entry name" value="RG-lyase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029411">
        <property type="entry name" value="RG-lyase_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016590">
        <property type="entry name" value="Rhamnogalacturonase_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015364">
        <property type="entry name" value="RhgB_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36574">
        <property type="entry name" value="RHAMNOGALACTURONATE LYASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36574:SF1">
        <property type="entry name" value="RHAMNOGALACTURONATE LYASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14683">
        <property type="entry name" value="CBM-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14686">
        <property type="entry name" value="fn3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09284">
        <property type="entry name" value="RhgB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49452">
        <property type="entry name" value="Starch-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="10" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008058469" description="rhamnogalacturonan endolyase" evidence="12">
        <location>
            <begin position="20"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="domain" description="Rhamnogalacturonase B N-terminal" evidence="13">
        <location>
            <begin position="21"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="Rhamnogalacturonan lyase" evidence="15">
        <location>
            <begin position="286"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="Rhamnogalacturonan lyase" evidence="14">
        <location>
            <begin position="372"/>
            <end position="543"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF09284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF14683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF14686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OAG09009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="547" mass="59862" checksum="57A867D7FB76A20C" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CRT9</accession>
    <name>A0A177CRT9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1212908</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG09479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039844.1">
        <property type="nucleotide sequence ID" value="XM_018182487.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CRT9"/>
    <dbReference type="GeneID" id="28765973"/>
    <dbReference type="InParanoid" id="A0A177CRT9"/>
    <dbReference type="OrthoDB" id="3793529at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG09479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="220" mass="25255" checksum="674E43B9E64FE877" modified="2016-09-07" version="1">MTSSGARGNAHLDTLPASLLLEIFSHRTPRASMQTPATSDGREKHNTSHLDTSLRNVRAVDGDFFHVRRNAKDMSNWNVESMVMDGSLYGWDSYRHHGETFHEYLRLRDLDRRLGLSEVWLVDQDEDDDEEEDAVDPLDEEAWKQQLQDEGSNYERATVLCLCPNIEEMLSGSNFNDNRREYPEDEDSVAIRPIVSAGKGEGFGRAHRFEHLRYLSIDVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CRX4</accession>
    <name>A0A177CRX4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative GNAT family acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1160661</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG09527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039892.1">
        <property type="nucleotide sequence ID" value="XM_018177549.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CRX4"/>
    <dbReference type="STRING" id="1460663.A0A177CRX4"/>
    <dbReference type="GeneID" id="28761035"/>
    <dbReference type="InParanoid" id="A0A177CRX4"/>
    <dbReference type="OrthoDB" id="2832510at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052523">
        <property type="entry name" value="Trichothecene_AcTrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791">
        <property type="entry name" value="GNAT FAMILY ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791:SF14">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13508">
        <property type="entry name" value="Acetyltransf_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="105"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG09527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="243" mass="27223" checksum="1F4A96F6E452651E" modified="2016-09-07" version="1">MAEPNITVESVSNADDFTQIFHCVSEAFGRQAKDTVWIVTSPGWDTPEGQKKGAADLVKRWQNVKTNKDGKPNTVFLKATLPDPADASKRRIAGMAIWQQASFVDGYGDIPTDDMSELLHTLDPTEARFAAQMFRSLWRRRIAYAKEKASADPPAIFVLDMCAVDPEFQRRGIAQKLVQWGLDEAKRRGELECTTEASSMGRGAYQKLGFQPEGTEDIVYEVDEEFSSRDKPPNVFLRTGIKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CS43</accession>
    <name>A0A177CS43_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Chloride channel protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CC84DRAFT_1111447</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the chloride channel (TC 2.A.49) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG09788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040153.1">
        <property type="nucleotide sequence ID" value="XM_018175280.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CS43"/>
    <dbReference type="FunCoup" id="A0A177CS43">
        <property type="interactions" value="335"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CS43"/>
    <dbReference type="GeneID" id="28758766"/>
    <dbReference type="InParanoid" id="A0A177CS43"/>
    <dbReference type="OrthoDB" id="44789at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005247">
        <property type="term" value="F:voltage-gated chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006878">
        <property type="term" value="P:intracellular copper ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04591">
        <property type="entry name" value="CBS_pair_voltage-gated_CLC_euk_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03684">
        <property type="entry name" value="ClC_3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3080.10:FF:000011">
        <property type="entry name" value="Chloride channel protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3080.10">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014743">
        <property type="entry name" value="Cl-channel_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001807">
        <property type="entry name" value="ClC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45711:SF9">
        <property type="entry name" value="ANION_PROTON EXCHANGE TRANSPORTER GEF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45711">
        <property type="entry name" value="CHLORIDE CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00654">
        <property type="entry name" value="Voltage_CLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00762">
        <property type="entry name" value="CLCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81340">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0129">CBS domain</keyword>
    <keyword evidence="7 9" id="KW-0868">Chloride</keyword>
    <keyword evidence="5 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="116"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="184"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="217"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="286"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="322"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="363"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="403"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="453"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="478"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="11">
        <location>
            <begin position="611"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="11">
        <location>
            <begin position="719"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="681"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="830"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="682"/>
            <end position="692"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OAG09788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="856" mass="94633" checksum="2E1847712868DF80" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CSS9</accession>
    <name>A0A177CSS9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1237448</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040959.1">
        <property type="nucleotide sequence ID" value="XM_018183898.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CSS9"/>
    <dbReference type="STRING" id="1460663.A0A177CSS9"/>
    <dbReference type="GeneID" id="28767384"/>
    <dbReference type="InParanoid" id="A0A177CSS9"/>
    <dbReference type="OrthoDB" id="3774289at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG10594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="360" mass="39449" checksum="764794538B8AD849" modified="2016-09-07" version="1">MGRISNPKHSNGPNLAMDSFQLARNASLAIRVALGSDWNSPGGALSTVADKYILKRLDKAISSADDEQPDWEAYILIPLFNSCLSTYTAIDIDSKFVTQTVAVILLAYDIIRQRNAVPTQTDYNFIESTLDKFLTPESLVIIREVVEAESERYSGLNIDFGKVNGLFVLEALLKEAIHRAENNGIVPEGATVKLMADSVKTQVPTASADEGFSSTPGLQTTTKRDVHLQYYLKSGYALEVDSVTSIDLHNEALVLETSDGLHVSIEEGVIVSEVEGKSRTVDIRAPQADGFELSATVVIPPDNSYIIEDVTSVERIDKMADWAVFETLKATIWVGNGAYMYERDGETVKVKNLFNICSTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CT22</accession>
    <name>A0A177CT22_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_491791</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041050.1">
        <property type="nucleotide sequence ID" value="XM_018186501.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CT22"/>
    <dbReference type="STRING" id="1460663.A0A177CT22"/>
    <dbReference type="GeneID" id="28769987"/>
    <dbReference type="InParanoid" id="A0A177CT22"/>
    <dbReference type="OrthoDB" id="6077919at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="382"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="409"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="441"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="500"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="259"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="304"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="468"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="555"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="96"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="222"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="311"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="570"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="594"/>
            <end position="608"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG10685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="608" mass="66724" checksum="9C403E338293926F" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CTU4</accession>
    <name>A0A177CTU4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Translin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CC84DRAFT_1084170</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the translin family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040675.1">
        <property type="nucleotide sequence ID" value="XM_018174039.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CTU4"/>
    <dbReference type="STRING" id="1460663.A0A177CTU4"/>
    <dbReference type="GeneID" id="28757525"/>
    <dbReference type="InParanoid" id="A0A177CTU4"/>
    <dbReference type="OrthoDB" id="31005at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14820">
        <property type="entry name" value="TRAX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.190">
        <property type="entry name" value="Translin, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.200">
        <property type="entry name" value="Translin, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016069">
        <property type="entry name" value="Translin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002848">
        <property type="entry name" value="Translin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016068">
        <property type="entry name" value="Translin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036081">
        <property type="entry name" value="Translin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10741">
        <property type="entry name" value="TRANSLIN AND TRANSLIN ASSOCIATED PROTEIN X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01997">
        <property type="entry name" value="Translin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74784">
        <property type="entry name" value="Translin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="176"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="181"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAG10310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="291" mass="32968" checksum="2BADFDA2BEC48FB9" modified="2016-09-07" version="1">MKEEKFEQPGQAPLPFMEMFEGFRAELDEHHDRRERIIKASRDITAASKKIIFTLQRVRTLGQSVPPFVVKGNAQYWEIIEKQYQHIAADVQGLNAFRYPQITGGNQEFMEALSFHHYLETQTLISYDDAKARVASMSGDTGAVLLTPEDYILGIFDMVGELMRFSITAMATNGKLPAGKPKKEVRSAKKEESEDQGADKMDVDEQTPAATPAEEPRNVLSDLRALRLQLEIFEPGGGKFGADVKKKADVMRECVDKVEKALYQLTVRGTERPKGWVPDVREERRPELESY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CU72</accession>
    <name>A0A177CU72_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PIN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1236879</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040674.1">
        <property type="nucleotide sequence ID" value="XM_018183887.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CU72"/>
    <dbReference type="STRING" id="1460663.A0A177CU72"/>
    <dbReference type="GeneID" id="28767373"/>
    <dbReference type="InParanoid" id="A0A177CU72"/>
    <dbReference type="OrthoDB" id="5361617at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="304"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="304"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="386"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="408"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="419"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG10309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="453" mass="50305" checksum="891CD7D1990023BD" modified="2016-09-07" version="1">MRRNTFPPRPRPDESRLRAAPEPPTRKVFNCIVDDTALIAGAKKSTRDGIRKWITQDAIRLFVPLHTLTQLNHLKTGPERYNSDARDALKWLDDVTSSPAIGDRIVLEGVDEAYTTWAEVEHFMLPETLLSMDSSGSEDEDEDDEYHEDLESSFNALDISDGTSMSSVDQSPKSTRTTEPDFAVPTGGLVDAKTMVTSNAAPVVESPARTARNSIELPRGQKPPKNSFPHSLRPLFNHILWRIHQETNPDAALDNFILLTNDTVKQGIAQKFGIRAKRLEQLRDAVMREDREFKNHLTVYKKETEEHALKKESELEPKVAQRPKSSHSSITKSAVDSDEDDCVLIKNAPRGPASSTSQRLFDPNDFGRATQPQSPRGGRGHPVLRGRGGSIRGRGAFAGRGRGGAYVPPAPSFQSPPAPRHDPNRPIDPDSFTRPATRGSPIRGGRRTLWEPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CUK3</accession>
    <name>A0A177CUK3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_489119</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040925.1">
        <property type="nucleotide sequence ID" value="XM_018186481.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CUK3"/>
    <dbReference type="GeneID" id="28769967"/>
    <dbReference type="InParanoid" id="A0A177CUK3"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG10560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="209" mass="22906" checksum="59306CF14577B950" modified="2016-09-07" version="1">MRFFPRGHVSTGDLGEHLKPRPAPNPRRKSSDPRPQSSSPFLPPTPSHHTVQPRTPPTSLNPASDRHSHTPPSPARAHRRAIPSCRPAAGLQQAARTRRIYEVALAATGPAVRTAFRQFAACFKQNAHGRMSRASQTGIYLCNAKVACRCTCSRNRLMVHGSRVPTFASNLMVCDQVPRHRRDIIHTAAQQISSLATGITQSLPHSSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CUV1</accession>
    <name>A0A177CUV1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ZIP zinc/iron transport family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CC84DRAFT_1084803</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ZIP transporter (TC 2.A.5) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040932.1">
        <property type="nucleotide sequence ID" value="XM_018174070.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CUV1"/>
    <dbReference type="FunCoup" id="A0A177CUV1">
        <property type="interactions" value="489"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CUV1"/>
    <dbReference type="GeneID" id="28757556"/>
    <dbReference type="InParanoid" id="A0A177CUV1"/>
    <dbReference type="OrthoDB" id="448280at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000007">
        <property type="term" value="F:low-affinity zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071578">
        <property type="term" value="P:zinc ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004698">
        <property type="entry name" value="Zn/Fe_permease_fun/pln"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00820">
        <property type="entry name" value="zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040:SF69">
        <property type="entry name" value="ZINC-REGULATED TRANSPORTER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040">
        <property type="entry name" value="ZINC/IRON TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="40"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="74"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="116"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="212"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="245"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="280"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="320"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="353"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="146"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="174"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAG10567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="374" mass="40788" checksum="9DD578CABA5A1996" modified="2016-09-07" version="1">MSLPMEVARLVLRQAEEGAEEEPSPGHCISSNAYDGRMGIRISSIFVILVGSMFGAVFPVFAKRNRQLGIPESLFFVAKYFGSGVIIATAFIHLLAPANEALGNPCLTGVITVYPWPEGIALMTIFLMFFLELMTMRFGNFGGEHSHDGHTHGSAPHDSVSLEDRSKTVGSEGDQSHGHQIGEDHLGHTRDHTDNSELGSDFEARGIIPETYAAQITAIFILEFGVIFHSIFIGLTLAVSGDEFITLYIVLVFHQMFEGLGLGSRLAMVPWPKSKRWTPYIMGIAYGLSTPIAIAVGLGVRTSYPPESTTTLLTNGVFDSISAGILIYTGLVELMAHEFMFSPYMQKGPISRMLWAFTLMVLGAGLMALLGYWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CVH5</accession>
    <name>A0A177CVH5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Acetyl-CoA synthetase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CC84DRAFT_1253724</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG11221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041586.1">
        <property type="nucleotide sequence ID" value="XM_018184396.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CVH5"/>
    <dbReference type="STRING" id="1460663.A0A177CVH5"/>
    <dbReference type="GeneID" id="28767882"/>
    <dbReference type="InParanoid" id="A0A177CVH5"/>
    <dbReference type="OrthoDB" id="1706066at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050218">
        <property type="term" value="F:propionate-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032387">
        <property type="entry name" value="ACAS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43347">
        <property type="entry name" value="ACYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43347:SF3">
        <property type="entry name" value="ACYL-COA SYNTHETASE SHORT-CHAIN FAMILY MEMBER 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16177">
        <property type="entry name" value="ACAS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acetyl-coenzyme A synthetase N-terminal" evidence="4">
        <location>
            <begin position="10"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="2">
        <location>
            <begin position="80"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="3">
        <location>
            <begin position="554"/>
            <end position="637"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAG11221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="699" mass="77047" checksum="03D0908CFB669904" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CVR9</accession>
    <name>A0A177CVR9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CID domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_501639</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041357.1">
        <property type="nucleotide sequence ID" value="XM_018186564.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CVR9"/>
    <dbReference type="FunCoup" id="A0A177CVR9">
        <property type="interactions" value="490"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CVR9"/>
    <dbReference type="GeneID" id="28770050"/>
    <dbReference type="InParanoid" id="A0A177CVR9"/>
    <dbReference type="OrthoDB" id="343582at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005849">
        <property type="term" value="C:mRNA cleavage factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000993">
        <property type="term" value="F:RNA polymerase II complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006369">
        <property type="term" value="P:termination of RNA polymerase II transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16982">
        <property type="entry name" value="CID_Pcf11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.90:FF:000016">
        <property type="entry name" value="mRNA cleavage factor complex component Pcf11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006569">
        <property type="entry name" value="CID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045154">
        <property type="entry name" value="PCF11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054127">
        <property type="entry name" value="Pcf11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047415">
        <property type="entry name" value="Pcf11_CID"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15921:SF3">
        <property type="entry name" value="PRE-MRNA CLEAVAGE COMPLEX 2 PROTEIN PCF11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15921">
        <property type="entry name" value="PRE-MRNA CLEAVAGE COMPLEX II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04818">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21936">
        <property type="entry name" value="Pcf11_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00582">
        <property type="entry name" value="RPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51391">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CID" evidence="2">
        <location>
            <begin position="4"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="357"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="418"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="446"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="669"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="364"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="383"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="424"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="459"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="474"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG10992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="696" mass="75465" checksum="1BE3DBC88B7C2867" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CWD4</accession>
    <name>A0A177CWD4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1253825</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG11348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041713.1">
        <property type="nucleotide sequence ID" value="XM_018184408.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CWD4"/>
    <dbReference type="GeneID" id="28767894"/>
    <dbReference type="InParanoid" id="A0A177CWD4"/>
    <dbReference type="OrthoDB" id="10558375at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="370"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="763"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="371"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="411"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="469"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="484"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="540"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="628"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="644"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="766"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="818"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="849"/>
            <end position="860"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG11348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="1064" mass="115968" checksum="2556852B9CE19A90" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CWF9</accession>
    <name>A0A177CWF9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">UDP-galactopyranose mutase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1158923</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG11378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041743.1">
        <property type="nucleotide sequence ID" value="XM_018177098.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CWF9"/>
    <dbReference type="STRING" id="1460663.A0A177CWF9"/>
    <dbReference type="GeneID" id="28760584"/>
    <dbReference type="InParanoid" id="A0A177CWF9"/>
    <dbReference type="OrthoDB" id="38045at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000220">
        <property type="entry name" value="UDP-galactopyranose mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43734:SF4">
        <property type="entry name" value="AMINE OXIDASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43734">
        <property type="entry name" value="PHYTOENE DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG11378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="535" mass="59743" checksum="87964E3E54AFCB75" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CWT7</accession>
    <name>A0A177CWT7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1211322</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG11671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042036.1">
        <property type="nucleotide sequence ID" value="XM_018182367.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CWT7"/>
    <dbReference type="GeneID" id="28765853"/>
    <dbReference type="InParanoid" id="A0A177CWT7"/>
    <dbReference type="OrthoDB" id="4133832at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG11671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="234" mass="27121" checksum="F712402B5109FDDE" modified="2016-09-07" version="1">MAGNATSQSRLLQLPGELRNRIYDFAREEGPVGEQSTTRSQPLFLGLTQTCRVIRNEYRPTYMAYTMFSMRLLDAYTFIPAYVKPHGEDSHGCMLINFDYGFSSIETNVLPLLKQLRRFSSLTAVATCSDITIQHAFRILLSACAREWFDDIAPLVTRITIKKNAPRHIDQAPRTILNWYLKCTVAKSPFFLSENANVMDIWAWEQRCFQWLFLEKDMNMHGLEVNFRPLWSGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CXA7</accession>
    <name>A0A177CXA7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1253986</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG11532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041897.1">
        <property type="nucleotide sequence ID" value="XM_018184427.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CXA7"/>
    <dbReference type="STRING" id="1460663.A0A177CXA7"/>
    <dbReference type="GeneID" id="28767913"/>
    <dbReference type="InParanoid" id="A0A177CXA7"/>
    <dbReference type="OrthoDB" id="1933717at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42901">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42901:SF1">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG11532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="312" mass="33955" checksum="51853EB16BE623A0" modified="2016-09-07" version="1">MDAIVDLKKTDFTATVHDTAYPAISPTRPELSQSGRVVLITGGGTGIGKAIAQNFVIASASHVVIVGRRLQVLEAAASELKKKALEVGSPSQVLTFKADVTVKSDVVGIFDDIASKGLLVDVLVLNAAKFAKLTPLIDLGMDELWTHMEANVKGPMLIAERFLKQNLSKKKFLVNVTTAAIHQQHHPLITTLAPYVLSKSAGTLFVQLLARQVPQDQLQVVTMHPGTVFADGFKDLGITEDMVPFDQADLPGAFAVWAASEEAAFVHNRLVWASWDVNELAHGDVRKRIEQDEDYLRISVIGFDLGKRAKRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CXI6</accession>
    <name>A0A177CXI6_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CC84DRAFT_1254294</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG11926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042291.1">
        <property type="nucleotide sequence ID" value="XM_018184449.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CXI6"/>
    <dbReference type="STRING" id="1460663.A0A177CXI6"/>
    <dbReference type="GeneID" id="28767935"/>
    <dbReference type="InParanoid" id="A0A177CXI6"/>
    <dbReference type="OrthoDB" id="10056939at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008422">
        <property type="entry name" value="KN_HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050224">
        <property type="entry name" value="TALE_homeobox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11850">
        <property type="entry name" value="HOMEOBOX PROTEIN TRANSCRIPTION FACTORS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05920">
        <property type="entry name" value="Homeobox_KN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 4" id="KW-0371">Homeobox</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="6">
        <location>
            <begin position="214"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="4">
        <location>
            <begin position="216"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="196"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="275"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="311"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="564"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="711"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="210"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="287"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="327"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="564"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="718"/>
            <end position="731"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAG11926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="731" mass="82450" checksum="AD73544AC2378780" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CXW6</accession>
    <name>A0A177CXW6_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">EamA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CC84DRAFT_1171148</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042779.1">
        <property type="nucleotide sequence ID" value="XM_018179897.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CXW6"/>
    <dbReference type="GeneID" id="28763383"/>
    <dbReference type="InParanoid" id="A0A177CXW6"/>
    <dbReference type="OrthoDB" id="306876at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22911">
        <property type="entry name" value="ACYL-MALONYL CONDENSING ENZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22911:SF6">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER G1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="31"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="60"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="121"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="152"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="184"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="239"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="6">
        <location>
            <begin position="121"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAG12414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="299" mass="31482" checksum="9193935FD4A12C0C" modified="2016-09-07" version="1">MMITTAFLSWPTAYFLQLPSLPLGPPPARPLLFIRGIAGAIGIWGFYYSLRSLALSEASIINFLSPTLAALLLSLLPSSSTSSSGISLAQLAAGGISMGGAVCVLQPWITQPEVGGGHRALAILAAVVGVAGGAVSYVAMARLGDSVHPAHTLAYFSTTTAVLSALLILVQWQPLHLPSAPMQWGLTLLLGVLGFAMHWLMTASLAQADDAKRPLNFVYTQMVFAMVADRVVWGVGFDVWKYLGGALIIASAVFVASTAEKMSHQYALVDGQGAAEEDEVELEMGKERADVAVAKDVEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CYN6</accession>
    <name>A0A177CYN6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cyanovirin-N</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1159709</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042751.1">
        <property type="nucleotide sequence ID" value="XM_018177304.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CYN6"/>
    <dbReference type="STRING" id="1460663.A0A177CYN6"/>
    <dbReference type="GeneID" id="28760790"/>
    <dbReference type="InParanoid" id="A0A177CYN6"/>
    <dbReference type="OrthoDB" id="2441380at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.60.10">
        <property type="entry name" value="Cyanovirin-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011058">
        <property type="entry name" value="Cyanovirin-N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036673">
        <property type="entry name" value="Cyanovirin-N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42076:SF1">
        <property type="entry name" value="CYANOVIRIN-N DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42076">
        <property type="entry name" value="CYANOVIRIN-N HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08881">
        <property type="entry name" value="CVNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01111">
        <property type="entry name" value="CVNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51322">
        <property type="entry name" value="Cyanovirin-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyanovirin-N" evidence="1">
        <location>
            <begin position="2"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG12386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="108" mass="12237" checksum="256B9C58E6813EB8" modified="2016-09-07" version="1">MTFHYSAEEGSIRVDDNHILRARLQRADGEWQDAEIDLNNHIGNDNGSFFWDGENFADSAQDVHFTIEGDGEVPVLRATLLNEDGEGIERDLNLSERIVNNDGNFLFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CYX3</accession>
    <name>A0A177CYX3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_157916</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018043099.1">
        <property type="nucleotide sequence ID" value="XM_018185410.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CYX3"/>
    <dbReference type="STRING" id="1460663.A0A177CYX3"/>
    <dbReference type="GeneID" id="28768896"/>
    <dbReference type="InParanoid" id="A0A177CYX3"/>
    <dbReference type="OrthoDB" id="5399006at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43431">
        <property type="entry name" value="OXIDOREDUCTASE, SHORT CHAIN DEHYDROGENASE/REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_5G14000)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43431:SF7">
        <property type="entry name" value="OXIDOREDUCTASE, SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_5G14000)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG12734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="247" mass="26110" checksum="B4BD76E0218DA5A2" modified="2016-09-07" version="1">MSSKLIAIVAGVGAGTGAAVARKFAATYPVVLLARNPDSYQSLAEEINASGGKAIGISTDVSDSKSVQLAVDAIKKEFGSDVAAAAAIFNASGGFMRRPFLEVPEDAFTQSLTVSAKGGFLFSQATLPLLLEGVKQKSQYPPSLIFTGATASVKSSAQMSSFSTGKWALRALSQSLAKEFGPEGVHVSHAIIDGVIDIPRTKGWLKDAGPDAKLSADGIANDYWYLHTQPRTNFTWELDLRPAVEKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CZ31</accession>
    <name>A0A177CZ31_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Protein HIR</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CC84DRAFT_1135790</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 12">Required for replication-independent chromatin assembly and for the periodic repression of histone gene transcription during the cell cycle.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the WD repeat HIR1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018043159.1">
        <property type="nucleotide sequence ID" value="XM_018176074.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CZ31"/>
    <dbReference type="FunCoup" id="A0A177CZ31">
        <property type="interactions" value="162"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CZ31"/>
    <dbReference type="GeneID" id="28759560"/>
    <dbReference type="InParanoid" id="A0A177CZ31"/>
    <dbReference type="OrthoDB" id="1741719at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000417">
        <property type="term" value="C:HIR complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000290">
        <property type="entry name" value="Protein HIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001557">
        <property type="entry name" value="Protein HIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055410">
        <property type="entry name" value="Beta-prop_CAF1B_HIR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031120">
        <property type="entry name" value="HIR1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011494">
        <property type="entry name" value="HIRA-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019015">
        <property type="entry name" value="HIRA_B_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13831">
        <property type="entry name" value="MEMBER OF THE HIR1 FAMILY OF WD-REPEAT PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13831:SF0">
        <property type="entry name" value="PROTEIN HIRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24105">
        <property type="entry name" value="Beta-prop_CAF1B_HIR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07569">
        <property type="entry name" value="Hira"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09453">
        <property type="entry name" value="HIRA_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="10 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 12" id="KW-0678">Repressor</keyword>
    <keyword evidence="9 12" id="KW-0804">Transcription</keyword>
    <keyword evidence="8 12" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5 11 12" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="20"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="domain" description="CAF1B/HIR1 beta-propeller" evidence="15">
        <location>
            <begin position="28"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="66"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="126"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="169"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="Protein HIRA-like C-terminal" evidence="14">
        <location>
            <begin position="719"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="435"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="449"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU364014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF07569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF24105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OAG12794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="1014" mass="109374" checksum="3409708A4395B741" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2023-06-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CZ70</accession>
    <name>A0A177CZ70_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1227113</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042941.1">
        <property type="nucleotide sequence ID" value="XM_018183603.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CZ70"/>
    <dbReference type="GeneID" id="28767089"/>
    <dbReference type="InParanoid" id="A0A177CZ70"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG12576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="134" mass="15396" checksum="482133463B760D1A" modified="2016-09-07" version="1">MDVDRTTLAQPEQSIYSVPGISALESQSPRYQAHKIFSLAFAQGMSQHYSNRASSVIRPVQHLLTFPTQMANYPWHPCLSPRSICQHEVVPQRRPRSAYKYRTASEYDLGQRPYPPQPRFLEQICNRFPCAGTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CZK3</accession>
    <name>A0A177CZK3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_112811</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042697.1">
        <property type="nucleotide sequence ID" value="XM_018175787.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CZK3"/>
    <dbReference type="GeneID" id="28759273"/>
    <dbReference type="InParanoid" id="A0A177CZK3"/>
    <dbReference type="OrthoDB" id="3770142at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008058794" evidence="1">
        <location>
            <begin position="21"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG12332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="174" mass="19247" checksum="3A3BDDC152353C89" modified="2016-09-07" version="1">MKYTSAVTIAVATLLHSVNANFDLYRVGLGGTGVSGNGEGWQAYEAEANCDNKLDWYWVDSEDVSGGKYGVRCEGDGCGRSQDDDDKSLDVIEMNFNRDEHHWTYYKDRDGALVDLSDNQVGRCYPFPGPNLNCGLTVGRVDGYRKIRCEIDVTADDINGGRPSKRRAARDFTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CZM3</accession>
    <name>A0A177CZM3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Natural resistance-associated macrophage protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CC84DRAFT_1071143</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042665.1">
        <property type="nucleotide sequence ID" value="XM_018173672.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CZM3"/>
    <dbReference type="FunCoup" id="A0A177CZM3">
        <property type="interactions" value="245"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CZM3"/>
    <dbReference type="GeneID" id="28757158"/>
    <dbReference type="InParanoid" id="A0A177CZM3"/>
    <dbReference type="OrthoDB" id="409173at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015086">
        <property type="term" value="F:cadmium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005384">
        <property type="term" value="F:manganese ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030026">
        <property type="term" value="P:intracellular manganese ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034755">
        <property type="term" value="P:iron ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00221">
        <property type="entry name" value="NRAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001046">
        <property type="entry name" value="NRAMP_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01197">
        <property type="entry name" value="nramp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF037982">
        <property type="entry name" value="Nramp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11706:SF101">
        <property type="entry name" value="MANGANESE TRANSPORTER SMF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11706">
        <property type="entry name" value="SOLUTE CARRIER PROTEIN FAMILY 11 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01566">
        <property type="entry name" value="Nramp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00447">
        <property type="entry name" value="NATRESASSCMP"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="131"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="169"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="211"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="242"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="274"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="318"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="405"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="450"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="496"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="526"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="574"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="46"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="361"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="55"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="602"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAG12300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="602" mass="63215" checksum="BBEFD47F79947619" modified="2016-09-07" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CZS1</accession>
    <name>A0A177CZS1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Clavaminate synthase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_129342</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042953.1">
        <property type="nucleotide sequence ID" value="XM_018185366.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CZS1"/>
    <dbReference type="STRING" id="1460663.A0A177CZS1"/>
    <dbReference type="GeneID" id="28768852"/>
    <dbReference type="InParanoid" id="A0A177CZS1"/>
    <dbReference type="OrthoDB" id="263283at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041667">
        <property type="entry name" value="Cupin_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12461">
        <property type="entry name" value="HYPOXIA-INDUCIBLE FACTOR 1 ALPHA INHIBITOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12461:SF105">
        <property type="entry name" value="HYPOXIA-INDUCIBLE FACTOR 1-ALPHA INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13621">
        <property type="entry name" value="Cupin_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="JmjC" evidence="2">
        <location>
            <begin position="126"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG12588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="293" mass="32875" checksum="C53FE7E0AD4C2C0B" modified="2016-09-07" version="1">MLARRTVQQIARNKRPYSQHSRFAPAKRLDGTLTHVKSLDLSEPIVLPRQFVDIPAINNWFTPAGSPEDDGVCHELKTSYLGRHGSLLVPLEYTRYDSDEGAVDGRKTIATFESIQAPLSLLLSHISSEDYSQQLYLAQCSIDDLPSDLQADLPTPGLISCLGRGDIYASSIWMGRPPTSTPLHRDPNPNLFVQLVGKKVIRLVRPKQGRHLYDRLRTQMGHAHMRGEEMMVGDERNRLHDVVWNEKEVNGVSASGVEARIEGGDGLYIPHGWWHAVESIGSHANASANWWFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2023-06-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CZX8</accession>
    <name>A0A177CZX8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_122839</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042785.1">
        <property type="nucleotide sequence ID" value="XM_018183636.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CZX8"/>
    <dbReference type="GeneID" id="28767122"/>
    <dbReference type="InParanoid" id="A0A177CZX8"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG12420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="167" mass="19109" checksum="5020C4EB42C1EEFC" modified="2016-09-07" version="1">MTHWVFTQGWRPIFSIYIQNGQSTPTNSVMVYRLASVAFIPNVSFRREPGSIPGNGKSSFLPQPLHIYVNTPSFWFCQVASGRLLLNYHVQLRSRVVVSIVRTIHADMCSSFVHLMHVITREALVKLYLLFSYHAWSRHNNAQSSLNRFIYDSSNVKKGDGPFTIFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177D0M7</accession>
    <name>A0A177D0M7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ARM repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CC84DRAFT_155967</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018043067.1">
        <property type="nucleotide sequence ID" value="XM_018185397.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177D0M7"/>
    <dbReference type="FunCoup" id="A0A177D0M7">
        <property type="interactions" value="1045"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177D0M7"/>
    <dbReference type="GeneID" id="28768883"/>
    <dbReference type="InParanoid" id="A0A177D0M7"/>
    <dbReference type="OrthoDB" id="431626at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000373">
        <property type="entry name" value="Importin beta-5 subunit, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056840">
        <property type="entry name" value="HEAT_IPO9_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997">
        <property type="entry name" value="IMPORTIN-7, 8, 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997:SF9">
        <property type="entry name" value="IMPORTIN-9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25018">
        <property type="entry name" value="HEAT_IPO9_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="6">
        <location>
            <begin position="23"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1007"/>
            <end position="1030"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="1015"/>
            <end position="1029"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAG12702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="1100" mass="122367" checksum="81A8994A5391A5C8" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177D1Q0</accession>
    <name>A0A177D1Q0_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ABM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1160200</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018043324.1">
        <property type="nucleotide sequence ID" value="XM_018177436.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177D1Q0"/>
    <dbReference type="GeneID" id="28760922"/>
    <dbReference type="InParanoid" id="A0A177D1Q0"/>
    <dbReference type="OrthoDB" id="3542212at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42052">
        <property type="entry name" value="ABM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42052:SF1">
        <property type="entry name" value="ABM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG12959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="174" mass="20066" checksum="2A654F544A4409EB" modified="2016-09-07" version="1">MPVTEYSRLTLKQGLNKEQIIFAKRGLSRAKKLMEDFTGHDFHIFQEVEDPDHIYIVGQWASVEQHMKSWIPSEANQGLLKDLGPLVDVDYLFHIVVSFGSIPPSEKSPVFSIGRHVMESEKRPDFESTFESRRHGLEMHAPGSISGGWRIEKEPGREEFVLFTPWKYVSRSIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2023-06-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BT92</accession>
    <name>A0A177BT92_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1182129</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441568">
        <property type="protein sequence ID" value="OAF98524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018028890.1">
        <property type="nucleotide sequence ID" value="XM_018180602.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BT92"/>
    <dbReference type="GeneID" id="28764088"/>
    <dbReference type="InParanoid" id="A0A177BT92"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAF98524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="196" mass="21204" checksum="76E76B0FD69CCCD1" modified="2016-09-07" version="1">MGIKAFQPHLEGKYSVPNLGQSIALQQRSIIFSIVDHSVAVKAIACDLTHRKIVLTSTANAPISEQIARFPKLMLPGYDKSNSSSPLILAGDAASRVPTLAARTKLSSRVMLLSPERRTRAAMPSLQSQSTQNTRGGITKLQLNPFDIFEPDVRILATNEETTTIICWFVPIATPLGPPVSAQLCTRSAFATHPGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BUB2</accession>
    <name>A0A177BUB2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1191704</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441564">
        <property type="protein sequence ID" value="OAF98864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029230.1">
        <property type="nucleotide sequence ID" value="XM_018181200.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BUB2"/>
    <dbReference type="STRING" id="1460663.A0A177BUB2"/>
    <dbReference type="GeneID" id="28764686"/>
    <dbReference type="InParanoid" id="A0A177BUB2"/>
    <dbReference type="OrthoDB" id="3934656at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF168">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAF98864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="341" mass="38165" checksum="AB1232FC423988F4" modified="2016-09-07" version="1">MYNTNPTLGLSIVLALRTAVSVHVVWQWRRLSHIPRPFSASLSKWSMLKESLKGEQSNSFQVLNDKYGSLVRVGPNELITRSRRSAKDDGGLFSMRDEIAHNQLRIKMAAGSIDGQIEEFVHLLNEICLSTDEKCRPKDFAEKKSFLTLDVMSKLAFGEAFGYLDQDRDVYDYLNTTATPTAGSRRDMLGSFIRHGLTQEEASGEALLHVVASSDTSAARLQAVMLGILTYPSTYRRLQSEIDDGIKTGTVPPAGDIIDGKFIQGGTQIGSSPLGFAEMVSTVDLVFHFVKFQCPGKNFALMEYLLPRFDFSITRPDRPVKVSNAGIWIMKDFWLRIEKRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BUP3</accession>
    <name>A0A177BUP3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">SWIRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CC84DRAFT_1131811</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the flavin monoamine oxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441563">
        <property type="protein sequence ID" value="OAF99014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029380.1">
        <property type="nucleotide sequence ID" value="XM_018175914.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BUP3"/>
    <dbReference type="STRING" id="1460663.A0A177BUP3"/>
    <dbReference type="GeneID" id="28759400"/>
    <dbReference type="InParanoid" id="A0A177BUP3"/>
    <dbReference type="OrthoDB" id="9982100at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000064">
        <property type="entry name" value="Lysine-specific histone demethylase 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.660.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050281">
        <property type="entry name" value="Flavin_monoamine_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007526">
        <property type="entry name" value="SWIRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10742">
        <property type="entry name" value="FLAVIN MONOAMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10742:SF386">
        <property type="entry name" value="LYSINE-SPECIFIC HISTONE DEMETHYLASE 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04433">
        <property type="entry name" value="SWIRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50934">
        <property type="entry name" value="SWIRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SWIRM" evidence="6">
        <location>
            <begin position="229"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="HMG box" evidence="5">
        <location>
            <begin position="994"/>
            <end position="1074"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="3">
        <location>
            <begin position="994"/>
            <end position="1074"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="59"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="155"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="511"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="177"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAF99014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1123" mass="124189" checksum="E4B27EF2306D9F1F" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BVF5</accession>
    <name>A0A177BVF5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1169682</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441563">
        <property type="protein sequence ID" value="OAF98950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029316.1">
        <property type="nucleotide sequence ID" value="XM_018179723.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BVF5"/>
    <dbReference type="GeneID" id="28763209"/>
    <dbReference type="InParanoid" id="A0A177BVF5"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAF98950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="54" mass="5496" checksum="F2FC374741C19322" modified="2016-09-07" version="1">MSRLSWVPRRAVIGPPVEPLPSCIPPATSKASRPPLAKPAGTSSLATQSAMTGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BW31</accession>
    <name>A0A177BW31_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Metallo-hydrolase/oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_427898</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441564">
        <property type="protein sequence ID" value="OAF98868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029234.1">
        <property type="nucleotide sequence ID" value="XM_018186192.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BW31"/>
    <dbReference type="STRING" id="1460663.A0A177BW31"/>
    <dbReference type="GeneID" id="28769678"/>
    <dbReference type="InParanoid" id="A0A177BW31"/>
    <dbReference type="OrthoDB" id="449487at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050313">
        <property type="term" value="F:sulfur dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070813">
        <property type="term" value="P:hydrogen sulfide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07724">
        <property type="entry name" value="POD-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.15.10:FF:000033">
        <property type="entry name" value="MBL fold metallo-hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051682">
        <property type="entry name" value="Mito_Persulfide_Diox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044528">
        <property type="entry name" value="POD-like_MBL-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43084">
        <property type="entry name" value="PERSULFIDE DIOXYGENASE ETHE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43084:SF1">
        <property type="entry name" value="PERSULFIDE DIOXYGENASE ETHE1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="2">
        <location>
            <begin position="16"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAF98868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="303" mass="34187" checksum="80C17DAE1CE1C5CB" modified="2016-09-07" version="1">MSNTPEIYPCFEPKTSTWQYIVADPQTREAVIIDSVLDFDPASNSLSTATADSLLSIIDEQKYSVTRILETHVHADHLTASRYLQQQLINRGQPRADVCIGKRIQLVQHTLAARYSISSPELESAFDYLFDDDERFSIGSIEAYVLHLPGHTPDHVGYVIGESVFTGDSIFNPDVGSARCDFPGGSAHALFCSMQKLLSLPPDYRLYTGHDYPPEARALSEHGQKWKAYTTVKEQNLTNKHVRNGVSEDQFVTWRTERDVALSEPRLLHQSLQVNIRGGRLPRRNTEGYRFLIIPLKVPESLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BWY4</accession>
    <name>A0A177BWY4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Protein-S-isoprenylcysteine O-methyltransferase</fullName>
            <ecNumber evidence="3 10">2.1.1.100</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CC84DRAFT_1200107</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>[protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine + S-adenosyl-L-methionine = [protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine methyl ester + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:21672"/>
            <dbReference type="Rhea" id="RHEA-COMP:12125"/>
            <dbReference type="Rhea" id="RHEA-COMP:12126"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:90510"/>
            <dbReference type="ChEBI" id="CHEBI:90511"/>
            <dbReference type="EC" id="2.1.1.100"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Endoplasmic reticulum membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the class VI-like SAM-binding methyltransferase superfamily. Isoprenylcysteine carboxyl methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.100" evidence="3 10"/>
    <dbReference type="EMBL" id="KV441562">
        <property type="protein sequence ID" value="OAF99470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029836.1">
        <property type="nucleotide sequence ID" value="XM_018181651.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BWY4"/>
    <dbReference type="FunCoup" id="A0A177BWY4">
        <property type="interactions" value="492"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177BWY4"/>
    <dbReference type="GeneID" id="28765137"/>
    <dbReference type="InParanoid" id="A0A177BWY4"/>
    <dbReference type="OrthoDB" id="422086at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004671">
        <property type="term" value="F:protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007269">
        <property type="entry name" value="ICMT_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025770">
        <property type="entry name" value="PPMT_MeTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12714">
        <property type="entry name" value="PROTEIN-S ISOPRENYLCYSTEINE O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12714:SF9">
        <property type="entry name" value="PROTEIN-S-ISOPRENYLCYSTEINE O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04140">
        <property type="entry name" value="ICMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51564">
        <property type="entry name" value="SAM_ICMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="66"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="165"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="206"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="232"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OAF99470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="284" mass="32030" checksum="E67149DF32ECFA68" modified="2016-09-07" version="1">MASQNGAPSSPHADISFPVNRPAEPGKWTPELDAKIRAQEAANIQLKKTILPRYLWPGGDRSLAGIAIRAFLLGVSGAMGFLLTVALAYNGIRLWRPCFFLGVLCVFHFLEFWTTAAYNTPTAYISSFLLTNGSRYRQAHTVAFVETITTSYFFPGWQACVHPPWVVALGVVMIVVGQVVRSLAMVQAGTNFNHQVQQHKNEGHELVTTGLYSVFRHPSYFGFFWWGLGTQVALGNTVSFVGYAGILWYFFYTRITHEEKHLIEFFGDDYKAYKTRTRVWIPFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BY96</accession>
    <name>A0A177BY96_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1049726</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441562">
        <property type="protein sequence ID" value="OAF99299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029665.1">
        <property type="nucleotide sequence ID" value="XM_018173458.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BY96"/>
    <dbReference type="GeneID" id="28756944"/>
    <dbReference type="InParanoid" id="A0A177BY96"/>
    <dbReference type="OrthoDB" id="3939900at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAF99299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="114" mass="13027" checksum="B556BDA4C04EBD39" modified="2016-09-07" version="1" fragment="single">LQLPPELLLELSDFLPVDGILALKLTHSILNNTLPAIPRLRNRTLDRCARFAIERHRTLPDEDRQQRRCMLCKKTYPKSQFSSSSSPACLSLAFDQDGPRPEVVELPDSFCAWH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2023-06-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BZC2</accession>
    <name>A0A177BZC2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1180773</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441560">
        <property type="protein sequence ID" value="OAF99931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030297.1">
        <property type="nucleotide sequence ID" value="XM_018180506.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BZC2"/>
    <dbReference type="GeneID" id="28763992"/>
    <dbReference type="InParanoid" id="A0A177BZC2"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAF99931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="157" mass="17831" checksum="BEFC249BAB747500" modified="2016-09-07" version="1">MRIQQSPAVFVPCPGPTMRFVCVPIAILRWMGQLEKDRMGEERGQGWSANERWLKAVILPACTSPPSSQRPMKDRTAQLLIPPCPPITTQKSTQGQSNVLHMDTKLNKRNQQKRGYLQTPAPPEKNYFGVCQKVISKRVIFWTQEKEGGYRKSGVVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2023-06-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BZK6</accession>
    <name>A0A177BZK6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_357305</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441560">
        <property type="protein sequence ID" value="OAG00022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030387.1">
        <property type="nucleotide sequence ID" value="XM_018185887.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BZK6"/>
    <dbReference type="GeneID" id="28769373"/>
    <dbReference type="InParanoid" id="A0A177BZK6"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG00022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="74" mass="8691" checksum="6FAB2F36C1DBA450" modified="2016-09-07" version="1">MAQYIWCRDKGQDYHLPIVVFEQRSEQRPTNPGIRVLWHRSIVARTCVLDDTSCYSNLTGERYGNMTWSSDLPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C058</accession>
    <name>A0A177C058_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF4419 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1168214</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441558">
        <property type="protein sequence ID" value="OAG01023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031388.1">
        <property type="nucleotide sequence ID" value="XM_018179340.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C058"/>
    <dbReference type="GeneID" id="28762826"/>
    <dbReference type="InParanoid" id="A0A177C058"/>
    <dbReference type="OrthoDB" id="9978173at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025533">
        <property type="entry name" value="DUF4419"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31252">
        <property type="entry name" value="DUF4419 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31252:SF11">
        <property type="entry name" value="DUF4419 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14388">
        <property type="entry name" value="DUF4419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="340"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="341"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="353"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG01023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="416" mass="46576" checksum="BE177A72C96F9F04" modified="2016-09-07" version="1">MPITVAIAKHDANAINTSNWDWRRMNNHEELLPHSEKNKSKGVLQSSVLPNEYFPKHIASSTNGLVWAAYYAYSDHHNLTLRPEDIWFAIISQLSFYINAHAEELRYLFVTHEERKELIVHTEGSINTIDFARIAKEVANMIQENVERADLQEWIMPSFSTTTESDRAVASVLFMGAMQKYFSYGACLSCGIPSVTLLGKREDWENILQRLDTLPEFGAEPAAFADGLRPVLQGFIATFDGERTPETLDFWGRIAHRTFGGSGPTYLSGWITAFCFWDADGKPISKRGWSEDLGAPACEVDFKDVPNGYAIVPLTINDNGKEYLTQMVAGSFGMEAFSQQKVKDTPDGHATTEDNSTTDSKTSNDGIRDEDPDSALDSIKPLTGWMMYHTNTFEDGHIKNLQPVADGSANRIDRTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C0D9</accession>
    <name>A0A177C0D9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_297759</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441559">
        <property type="protein sequence ID" value="OAG00359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030724.1">
        <property type="nucleotide sequence ID" value="XM_018185786.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C0D9"/>
    <dbReference type="GeneID" id="28769272"/>
    <dbReference type="InParanoid" id="A0A177C0D9"/>
    <dbReference type="OrthoDB" id="3799443at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG00359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="150" mass="16601" checksum="6AFCDD27736D704D" modified="2016-09-07" version="1">MARKRHIFVWHCCACGQASNNIGVGHCIRCGHGRCAYCQTEKVQIRAAISVTRLKYCLYQTIDESTRSFGTARPTYSTVLRYRAPQQYHHSGSRTAAAVATAMAESFESLDHPSSEAGSIIDPHAWPGDLQAYGTCFPIAWTRLVSSRFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C0L9</accession>
    <name>A0A177C0L9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1100973</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441558">
        <property type="protein sequence ID" value="OAG01183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031548.1">
        <property type="nucleotide sequence ID" value="XM_018174890.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C0L9"/>
    <dbReference type="GeneID" id="28758376"/>
    <dbReference type="InParanoid" id="A0A177C0L9"/>
    <dbReference type="OrthoDB" id="1517790at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.56.110">
        <property type="entry name" value="Protein of unknown function DUF2237"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018714">
        <property type="entry name" value="DUF2237"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37466">
        <property type="entry name" value="SLR1628 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37466:SF1">
        <property type="entry name" value="SLR1628 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09996">
        <property type="entry name" value="DUF2237"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG01183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="165" mass="18484" checksum="364EEE31E731095E" modified="2016-09-07" version="1">MRLLKNLLTGITKRRYAKVHDVQIKFVQDKEKKPIMDKNGKLHLRTSFHNQPLSLHGTSPLTGFLRTGYCEAPRSDAGNHSVAGIVTNEFLDFSAARGNDLRQAGLTDGCKWCLCVARWKEAFNARTGDDDRKVPRVVLSATNKRALEGATMEELKKFAVNEEGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C0Q4</accession>
    <name>A0A177C0Q4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mid2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_1168522</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441559">
        <property type="protein sequence ID" value="OAG00422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030787.1">
        <property type="nucleotide sequence ID" value="XM_018179419.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C0Q4"/>
    <dbReference type="STRING" id="1460663.A0A177C0Q4"/>
    <dbReference type="GeneID" id="28762905"/>
    <dbReference type="InParanoid" id="A0A177C0Q4"/>
    <dbReference type="OrthoDB" id="5338512at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008057544" description="Mid2 domain-containing protein" evidence="3">
        <location>
            <begin position="28"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="182"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="245"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="295"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="145"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="321"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="339"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="404"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAG00422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="427" mass="45368" checksum="F0B5007C89206B8B" modified="2016-09-07" version="1">MSRQAGPKLSRISLLLLAAVMIPAATASSLFLRAEPVCGGKSNLQQCGGDLPASFCCASDTTCTTVNSTIQAVICCPKGKDCSTIQTVPCDTTQYNATLFPDNQIHFAETADVELPKCGDACCPLGYKCSNGMCIASQDTPSSTVPIPTSSPTTSPASASQSSGCPPDALPPPASSFDAKSFAAGFFPGLLLGALGVIAFIWLTKRRRDAKAARYSGDFGHVARTISDPIYDPQHAQRTDFIRRGSHSVSSTPSVQKPIGTRAAGGGGHGLTPRIKSMWDRTPKLAMGVWSGLPLTPTLNLQPPPPAMRAGDPLRDPYRTPGQTPSQPSPESDEGATRTHSRRRKRKHSAKPSRRPLETPTRSTSSETIDVLMPAPSFLEPPKAPAMRENRMTADSGHTTFTKLMERAGYGEDSRESVRNLSSAGRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C1D0</accession>
    <name>A0A177C1D0_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1129457</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441559">
        <property type="protein sequence ID" value="OAG00642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031007.1">
        <property type="nucleotide sequence ID" value="XM_018175833.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C1D0"/>
    <dbReference type="GeneID" id="28759319"/>
    <dbReference type="InParanoid" id="A0A177C1D0"/>
    <dbReference type="OrthoDB" id="2148716at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00531">
        <property type="entry name" value="NTF2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13577">
        <property type="entry name" value="SnoaL_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="1">
        <location>
            <begin position="8"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG00642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="172" mass="18478" checksum="778C83A7773455A2" modified="2016-09-07" version="1" fragment="single">MPPANPLDALAIQNTLARYCEALDTKNWALLAKVFAPDCRADYPFNHSLHGASAISSAIQNRLGPILTHHSLTTSSLVFAPDGKSATATTFFVGCHFGQGPHEGKVLQAWGRYVDVLEVQAAKEDGDGGGDVDVDVDGSYEGVPGASGCWRIRKREVGFTKRIGDEKVMSEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C1E9</accession>
    <name>A0A177C1E9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1263501</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441559">
        <property type="protein sequence ID" value="OAG00547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030912.1">
        <property type="nucleotide sequence ID" value="XM_018185246.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C1E9"/>
    <dbReference type="GeneID" id="28768732"/>
    <dbReference type="InParanoid" id="A0A177C1E9"/>
    <dbReference type="OrthoDB" id="3780398at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008057610" evidence="1">
        <location>
            <begin position="17"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG00547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="144" mass="15023" checksum="D74261CE17F660BE" modified="2016-09-07" version="1">MHFSTILTNLALGASALAVAVTPRQQTSCFEPRNGVCLSRQADFNNATLAITNACNKIPSCSPGQADTARVSGVVRGFPYSAALKVGTQCAGVVPWSTQGCVDAFIAVIDQGCEQQYPSTDGLFQLGYFNAACDSSFVSFNLGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C1I2</accession>
    <name>A0A177C1I2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transportin-2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_1189818</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441557">
        <property type="protein sequence ID" value="OAG01503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031868.1">
        <property type="nucleotide sequence ID" value="XM_018181077.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C1I2"/>
    <dbReference type="FunCoup" id="A0A177C1I2">
        <property type="interactions" value="1184"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177C1I2"/>
    <dbReference type="GeneID" id="28764563"/>
    <dbReference type="InParanoid" id="A0A177C1I2"/>
    <dbReference type="OrthoDB" id="951172at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000313">
        <property type="entry name" value="Importin beta-2 subunit, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000219">
        <property type="entry name" value="Importin subunit beta-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040122">
        <property type="entry name" value="Importin_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034085">
        <property type="entry name" value="TOG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10527">
        <property type="entry name" value="IMPORTIN BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13513">
        <property type="entry name" value="HEAT_EZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01349">
        <property type="entry name" value="TOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="7">
        <location>
            <begin position="32"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="356"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="356"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="381"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAG01503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="943" mass="104203" checksum="F65265A9CA6F62F1" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C1N2</accession>
    <name>A0A177C1N2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Putative oligopeptide transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CC84DRAFT_1153461</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oligopeptide OPT transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441557">
        <property type="protein sequence ID" value="OAG01553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031918.1">
        <property type="nucleotide sequence ID" value="XM_018176839.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C1N2"/>
    <dbReference type="GeneID" id="28760325"/>
    <dbReference type="InParanoid" id="A0A177C1N2"/>
    <dbReference type="OrthoDB" id="9986677at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035673">
        <property type="term" value="F:oligopeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004648">
        <property type="entry name" value="Oligpept_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004813">
        <property type="entry name" value="OPT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00728">
        <property type="entry name" value="OPT_sfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22601">
        <property type="entry name" value="ISP4 LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03169">
        <property type="entry name" value="OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0571">Peptide transport</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="92"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="233"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="271"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="304"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="449"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="479"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="563"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="637"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="688"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="715"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OAG01553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="762" mass="86804" checksum="0EF77A9A33D276D4" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C1R4</accession>
    <name>A0A177C1R4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Phospholipase C/P1 nuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CC84DRAFT_1153992</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the nuclease type I family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441558">
        <property type="protein sequence ID" value="OAG00748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031113.1">
        <property type="nucleotide sequence ID" value="XM_018176861.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C1R4"/>
    <dbReference type="STRING" id="1460663.A0A177C1R4"/>
    <dbReference type="GeneID" id="28760347"/>
    <dbReference type="InParanoid" id="A0A177C1R4"/>
    <dbReference type="OrthoDB" id="441446at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006308">
        <property type="term" value="P:DNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11010">
        <property type="entry name" value="S1-P1_nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.575.10">
        <property type="entry name" value="P1 Nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008947">
        <property type="entry name" value="PLipase_C/P1_nuclease_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003154">
        <property type="entry name" value="S1/P1nuclease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33146">
        <property type="entry name" value="ENDONUCLEASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33146:SF26">
        <property type="entry name" value="ENDONUCLEASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02265">
        <property type="entry name" value="S1-P1_nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48537">
        <property type="entry name" value="Phospholipase C/P1 nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008057674" evidence="8">
        <location>
            <begin position="19"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAG00748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="304" mass="33853" checksum="98C0BA41333285BF" modified="2016-09-07" version="1">MHFLKLATFFLPSAASWSTDVHNQIGFMAEQFLEPHTISVVQHILEPQYNGSIGRAAAWADGYAHTDEGRFSYQWHWIDSHDFPPQRCDLDYNRDCAKGGCVVSAIENQTSILRGCIADVKAGSLANGANLTCSYALKWVSHFLGDINQPLHASGRAAGGNFFRVKFGNASTELHAVWDHYLPYTAAAATHPFSNQTIAPFFEGLVSRIRKDLFWEAPYMWLACSDPSTPVECATRWARESNKWTCDYVYSRVNATSDLAEDGYAAGGVPIVELQISKAALRLATWLNKLVGEENQKQVDQIEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C2L1</accession>
    <name>A0A177C2L1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Short chain alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_1198243</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441556">
        <property type="protein sequence ID" value="OAG01883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032248.1">
        <property type="nucleotide sequence ID" value="XM_018181557.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C2L1"/>
    <dbReference type="STRING" id="1460663.A0A177C2L1"/>
    <dbReference type="GeneID" id="28765043"/>
    <dbReference type="InParanoid" id="A0A177C2L1"/>
    <dbReference type="OrthoDB" id="47007at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24321">
        <property type="entry name" value="DEHYDROGENASES, SHORT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24321:SF8">
        <property type="entry name" value="ESTRADIOL 17-BETA-DEHYDROGENASE 8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="221"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAG01883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="286" mass="31252" checksum="06BCCA5F3988E034" modified="2016-09-07" version="1">MEINPAEPSASRNIIVSGGAQGIGRALGRYFLEAGHRIFIFDIQEEELEYTATKHLEKYHKDGKVGYAVCNLRNVDAIRSKVDEAAKFFGGQIDVLVNNGGIASPHWKDNKTMEDKETYDQWLAYMETNLTAPFAMSQACIPFMKHRESESHNSLGAHKHVAGPCIIHIGSFRAHQSDLNQEGYAASKAGQLGLMQAMSVSLGPLGIRTNLVAPGRIKVGHESKEGDEHGHTWEGQNTEKDIDDHTTNRAGRPKDIADACLYLINAGFVNGVDITVDGGALRKKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C332</accession>
    <name>A0A177C332_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative acc synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1151909</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441556">
        <property type="protein sequence ID" value="OAG01875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032240.1">
        <property type="nucleotide sequence ID" value="XM_018176774.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C332"/>
    <dbReference type="STRING" id="1460663.A0A177C332"/>
    <dbReference type="GeneID" id="28760260"/>
    <dbReference type="InParanoid" id="A0A177C332"/>
    <dbReference type="OrthoDB" id="7042322at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050478">
        <property type="entry name" value="Ethylene_sulfur-biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43795:SF39">
        <property type="entry name" value="AMINOTRANSFERASE CLASS I_CLASSII DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43795">
        <property type="entry name" value="BIFUNCTIONAL ASPARTATE AMINOTRANSFERASE AND GLUTAMATE/ASPARTATE-PREPHENATE AMINOTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00753">
        <property type="entry name" value="ACCSYNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="2">
        <location>
            <begin position="54"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG01875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="459" mass="50421" checksum="620EA079C9A25915" modified="2016-09-07" version="1">MSAPVSQSCVDFSLSQRGAHNSVQDSPWDAVERLMANLWATDNPDGLVFLGVAENSILHKQVAARANKNAAVNTNNHLNYGVGPRGSPRLKKALVPFFNSEFRPSKPILQKELLVLPGVAAVIDALTWAICNEGEGIITPAPFYTGLKPMSALRAGGVLISAPFKSVEGYRGLNDVFDPDMNRKALEKTLLQATQDGVTVRAVLISNPHNPLGRCYPAETIREIARFCGRNNLHLISDEIFALSVYHNVHANNATPFVSVLGAGLDECIDSHLVHVMYGMSKDFCATGLRLGVLHSTNEGLIAAVSSISVFGWVPYVVQDVWADVLEDKQFLGDFKLENRKVLGKHCTMLRSFLDQHKIPYYDHVHAGVFVWVDLRRYLRGNSAPRPAISAAGINHDQEVELFKRFLGAGVVVSQGSSFGTEELGWYRISFAMDEQALNLGLQRLGNCLKSIENNGWEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C393</accession>
    <name>A0A177C393_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_190492</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441557">
        <property type="protein sequence ID" value="OAG01379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031744.1">
        <property type="nucleotide sequence ID" value="XM_018185531.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C393"/>
    <dbReference type="GeneID" id="28769017"/>
    <dbReference type="InParanoid" id="A0A177C393"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="58"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG01379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="144" mass="15086" checksum="5D04B194C835D345" modified="2016-09-07" version="1">MRASVVQPPLAAVSLAAGGAFFSPERAPTALFGAEQHHLRRLCAAWPPRWGGRATKPAADARSSGVRGGARSRSRGLDKCVPKNRGSKTASERQDDVCASARRGGDVTPEGRMPWMGRGTQRTASPFIKRAKASAGGSPVGHSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2023-06-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C3W7</accession>
    <name>A0A177C3W7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1020848</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441556">
        <property type="protein sequence ID" value="OAG02434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032799.1">
        <property type="nucleotide sequence ID" value="XM_018173379.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C3W7"/>
    <dbReference type="GeneID" id="28756865"/>
    <dbReference type="InParanoid" id="A0A177C3W7"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG02434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="84" mass="8949" checksum="7AC0A66D81CE2BAA" modified="2016-09-07" version="1">MRPVTVSFTFGHVLTKSWGRVVLEEYTGAIVVEGFSCSRMTGGCSMVMTTAHPVTVRAQGLSVQDSLPSSEPCVSGLGGARRWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C438</accession>
    <name>A0A177C438_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cyclin-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_198079</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441557">
        <property type="protein sequence ID" value="OAG01487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031852.1">
        <property type="nucleotide sequence ID" value="XM_018185557.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C438"/>
    <dbReference type="STRING" id="1460663.A0A177C438"/>
    <dbReference type="GeneID" id="28769043"/>
    <dbReference type="InParanoid" id="A0A177C438"/>
    <dbReference type="OrthoDB" id="5304883at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013922">
        <property type="entry name" value="Cyclin_PHO80-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615:SF32">
        <property type="entry name" value="PROTEIN KINASE COMPLEX COMPONENT, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G07660)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08613">
        <property type="entry name" value="Cyclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG01487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="315" mass="34428" checksum="2572B16D493F7C8D" modified="2016-09-07" version="1">MLQVCHPTPPATVLPGHFAAPVRRTPRAMNPPSAPNPAGDAGVLPEFGSLSIRDAPSPPGEEELDVTNMSRETAMKILVRSVLALANAAGEIPATPPLSRPHTPSGKENVPGTRPHRRTASRPATPIPADRAQTSRTDLEQPEAHHDEPIIDIGAGAEPEYVQRANMARKFFSKSVPKVSLEEYCNRIQQYCPLSTGVWLAAGSYILRLSLVDKYVPLTHRTMHRLVLACLTTAMKTLEDHRWPQKRLAAVGGVDEMALGRLELCVEFLLSFDLQFLAENRLKDSTVALQKAGQAAVMTARLPSSFKLSIPRTRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C4B6</accession>
    <name>A0A177C4B6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1221057</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441557">
        <property type="protein sequence ID" value="OAG01567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031932.1">
        <property type="nucleotide sequence ID" value="XM_018183224.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C4B6"/>
    <dbReference type="GeneID" id="28766710"/>
    <dbReference type="InParanoid" id="A0A177C4B6"/>
    <dbReference type="OrthoDB" id="3641893at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG01567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="101" mass="11288" checksum="F64FDCC2A53336DD" modified="2016-09-07" version="1">MAPIDLLETVHSLAKRSDDNIAGIPKGLLVILIMISGGALVVVIYGLARFMFPEKEGMRTVGAEQADYMREVRVRNLNNLMADYAPRGPYRQRQSNTRVVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C4F4</accession>
    <name>A0A177C4F4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_218232</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441557">
        <property type="protein sequence ID" value="OAG01762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032127.1">
        <property type="nucleotide sequence ID" value="XM_018185619.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C4F4"/>
    <dbReference type="GeneID" id="28769105"/>
    <dbReference type="InParanoid" id="A0A177C4F4"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG01762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="202" mass="22316" checksum="A78873BD80C2E911" modified="2016-09-07" version="1">MHQSNSFAARAVMEMARQLDMAHRDLGPTPRGGGRGRHAAKRTCERSADRRLHVLADVWLPGCRRGLATGRRRVGGRPRRWCETMSESCSRSSQAAQKTQGPRRCTARSTQHAAHSTQHTAVSSTVRVPVTATTAGQLYQARVGSRLGAYLGAARAIESRASDFRFLPRRRRQLRARRRAVSPDFAGQAPADERPHLESASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C699</accession>
    <name>A0A177C699_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1179227</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441556">
        <property type="protein sequence ID" value="OAG02298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032663.1">
        <property type="nucleotide sequence ID" value="XM_018180398.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C699"/>
    <dbReference type="GeneID" id="28763884"/>
    <dbReference type="InParanoid" id="A0A177C699"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG02298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="233" mass="25307" checksum="C50CFB2FAA78D74A" modified="2016-09-07" version="1">MFDGADLIAYTGPNLGSVTVLMLVIAIVRYYRDPAEDAQSPLNCTPSMNGLVQSSQTIVSSAPHVGAALRARSIRRCSERLPLQNGCLSLLHKAPMAASDGTPPRSSLRLIAARRSILRSTEAAAVSGQAGRPFAQHLGRCSSSPIGSLSTLAFSQCFWYRNDSMAGLDIRCGLFTADHMQSGPVLPLFYLPDLARCNPSTQTQLQQPVVSTRTCFVSISSHLRFKSRSRFYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C782</accession>
    <name>A0A177C782_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">WSC-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CC84DRAFT_1197180</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG03405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033770.1">
        <property type="nucleotide sequence ID" value="XM_018181508.1"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177C782"/>
    <dbReference type="GeneID" id="28764994"/>
    <dbReference type="InParanoid" id="A0A177C782"/>
    <dbReference type="OrthoDB" id="5985073at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051836">
        <property type="entry name" value="Kremen_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002889">
        <property type="entry name" value="WSC_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24269">
        <property type="entry name" value="KREMEN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24269:SF25">
        <property type="entry name" value="WSC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01822">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00321">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51212">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="WSC" evidence="8">
        <location>
            <begin position="901"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="8">
        <location>
            <begin position="992"/>
            <end position="1083"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="8">
        <location>
            <begin position="1265"/>
            <end position="1355"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="8">
        <location>
            <begin position="1367"/>
            <end position="1458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1216"/>
            <end position="1253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1521"/>
            <end position="1562"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAG03405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="1580" mass="165876" checksum="07BA4E019E86D939" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C7W9</accession>
    <name>A0A177C7W9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Mitochondrial import inner membrane translocase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CC84DRAFT_1097970</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Heterohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Mitochondrion inner membrane</location>
            <topology evidence="1 12">Peripheral membrane protein</topology>
            <orientation evidence="1 12">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="12">The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the small Tim family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG02868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033233.1">
        <property type="nucleotide sequence ID" value="XM_018174744.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C7W9"/>
    <dbReference type="FunCoup" id="A0A177C7W9">
        <property type="interactions" value="894"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177C7W9"/>
    <dbReference type="GeneID" id="28758230"/>
    <dbReference type="InParanoid" id="A0A177C7W9"/>
    <dbReference type="OrthoDB" id="1551503at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.810">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit tim13 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050673">
        <property type="entry name" value="Mito_inner_translocase_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004217">
        <property type="entry name" value="Tim10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035427">
        <property type="entry name" value="Tim10-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13172">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM9B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02953">
        <property type="entry name" value="zf-Tim10_DDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144122">
        <property type="entry name" value="Tim10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 12" id="KW-0143">Chaperone</keyword>
    <keyword evidence="10 12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 12" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7 12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12" id="KW-0811">Translocation</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Tim10-like" evidence="13">
        <location>
            <begin position="11"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU367043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OAG02868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="88" mass="10149" checksum="A2319F324E6B5476" modified="2016-09-07" version="1" fragment="single">LSSAEQRELQNRMEKKQMKEFMNMYSNLVQQCFDNCVNGFESKSLTSREEGCIMKCVDKHMKGSQRLGDRFQEQNAAMAQGQQSGFGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C939</accession>
    <name>A0A177C939_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">mRNA N(6)-methyladenine demethylase</fullName>
            <ecNumber evidence="2">1.14.11.53</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CC84DRAFT_1198158</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>an N(6)-methyladenosine in mRNA + 2-oxoglutarate + O2 = an adenosine in mRNA + formaldehyde + succinate + CO2</text>
            <dbReference type="Rhea" id="RHEA:49520"/>
            <dbReference type="Rhea" id="RHEA-COMP:12414"/>
            <dbReference type="Rhea" id="RHEA-COMP:12417"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:16842"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74449"/>
            <dbReference type="EC" id="1.14.11.53"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:49521"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="9">Binds 1 Fe(2+) ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the alkB family.</text>
    </comment>
    <dbReference type="EC" id="1.14.11.53" evidence="2"/>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG03230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033595.1">
        <property type="nucleotide sequence ID" value="XM_018181549.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C939"/>
    <dbReference type="STRING" id="1460663.A0A177C939"/>
    <dbReference type="GeneID" id="28765035"/>
    <dbReference type="InParanoid" id="A0A177C939"/>
    <dbReference type="OrthoDB" id="6614653at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990931">
        <property type="term" value="F:mRNA N6-methyladenosine dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.590:FF:000014">
        <property type="entry name" value="Oxidoreductase, 2OG-Fe(II) oxygenase family family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.590">
        <property type="entry name" value="Alpha-ketoglutarate-dependent dioxygenase AlkB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004574">
        <property type="entry name" value="Alkb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027450">
        <property type="entry name" value="AlkB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037151">
        <property type="entry name" value="AlkB-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16557">
        <property type="entry name" value="ALKYLATED DNA REPAIR PROTEIN ALKB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16557:SF3">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE ALKB-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13532">
        <property type="entry name" value="2OG-FeII_Oxy_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6 9" id="KW-0408">Iron</keyword>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0843">Virulence</keyword>
    <feature type="domain" description="Alpha-ketoglutarate-dependent dioxygenase AlkB-like" evidence="11">
        <location>
            <begin position="171"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="9"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="254"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="256"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="315"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR604574-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF13532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OAG03230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="368" mass="41608" checksum="D86DD91EE17FB1AC" modified="2016-09-07" version="1">MDLSTAAAVEKKGSVHHDTHAQPPEFIQRQHWKYQSMRRADLENDTNVQDLSNWETFTKEKRNIWRLAGAIPGEQVQAACEAYAGGKPLDTTVEDVPFFEHRDFPGLQVVPALLPPETQVLFTSCLMHRDLADPGHKMNLQADYDVPYPPKSSSPTSHRFESSFFLRERAAEEDILAPKIPDKHKQLNTEQALYTKLRWLTLGEQYDWPTRSYAKHATPFPADLSTLVTGLFPHIRPESGVVLMYGAKDFMPVHRDVSEQCQRALASFSVGCDGIFIMARGEDGGEGDNAPRTVAIRVRSGDVVHLTGQARWAWHAMARTIPSTCPSYLSDWPVGTPNATPEEKKMYKKWKGYMGTKRINVSCRQVWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2023-06-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C9D0</accession>
    <name>A0A177C9D0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_970842</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG03378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033743.1">
        <property type="nucleotide sequence ID" value="XM_018188012.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C9D0"/>
    <dbReference type="GeneID" id="28771498"/>
    <dbReference type="InParanoid" id="A0A177C9D0"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG03378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="70" mass="8111" checksum="5A9A80EAF8EFFF0D" modified="2016-09-07" version="1">MELVGLTSYFVRKPTIRVHLEITLFTSSSQRQRLAHYELVADYLRQVLGIIPGQANLVLHPKRVRNDHSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CAL8</accession>
    <name>A0A177CAL8_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ribonuclease Z</fullName>
            <ecNumber evidence="4">3.1.26.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CC84DRAFT_1177762</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endonucleolytic cleavage of RNA, removing extra 3' nucleotides from tRNA precursor, generating 3' termini of tRNAs. A 3'-hydroxy group is left at the tRNA terminus and a 5'-phosphoryl group is left at the trailer molecule.</text>
            <dbReference type="EC" id="3.1.26.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase Z family.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.11" evidence="4"/>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG03818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034183.1">
        <property type="nucleotide sequence ID" value="XM_018180302.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A177CAL8">
        <property type="interactions" value="1185"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CAL8"/>
    <dbReference type="GeneID" id="28763788"/>
    <dbReference type="InParanoid" id="A0A177CAL8"/>
    <dbReference type="OrthoDB" id="527344at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042781">
        <property type="term" value="F:3'-tRNA processing endoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990180">
        <property type="term" value="P:mitochondrial tRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14810">
        <property type="entry name" value="bZIP_u1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07718">
        <property type="entry name" value="RNaseZ_ELAC1_ELAC2-C-term-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047151">
        <property type="entry name" value="RNZ2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027794">
        <property type="entry name" value="tRNase_Z_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12553">
        <property type="entry name" value="ZINC PHOSPHODIESTERASE ELAC PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12553:SF49">
        <property type="entry name" value="ZINC PHOSPHODIESTERASE ELAC PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13691">
        <property type="entry name" value="Lactamase_B_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="BZIP" evidence="13">
        <location>
            <begin position="290"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="35"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="197"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="269"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="590"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="992"/>
            <end position="1035"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1565"/>
            <end position="1588"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1633"/>
            <end position="1672"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="315"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="42"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="280"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="655"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="996"/>
            <end position="1005"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1565"/>
            <end position="1576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="1663"/>
            <end position="1672"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OAG03818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="1672" mass="184988" checksum="C53A077FC25E3BA5" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CB70</accession>
    <name>A0A177CB70_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">FAD dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CC84DRAFT_1247167</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FMO family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG04825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035190.1">
        <property type="nucleotide sequence ID" value="XM_018184227.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CB70"/>
    <dbReference type="GeneID" id="28767713"/>
    <dbReference type="InParanoid" id="A0A177CB70"/>
    <dbReference type="OrthoDB" id="66881at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000960">
        <property type="entry name" value="Flavin_mOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050346">
        <property type="entry name" value="FMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23023">
        <property type="entry name" value="DIMETHYLANILINE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000332">
        <property type="entry name" value="FMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00419">
        <property type="entry name" value="ADXRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAG04825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="487" mass="53121" checksum="66C4D904E7662A19" modified="2016-09-07" version="1">MSTSPKRAVVIGAGISGVVSAAHLRNEGLDVTVYERSSAAGGVWLYDERRPLEPAYPSVLPSKGEVYPDDPVLELTETETQAVRHAPPGPCYVGLKNNVGTRLLTTTLNSFPEGTEDYVSHSVLKDYIQDTAIKTGVERITHYGTEVKNLSKVNGKWKVETVALERNSTGNVERKSTTSNFDVVVVASGHYHAPRVPDIPGIGDVKRQFPTRITHSKGYRTPERFANRNVLLIGASVSSSDIARELGPIANSIYQSHRGGAFDLPASILPENATRIEEVVAFELSKENAEAIDENEPLPVTIKLKSGQTLCGIHDILVCTGYHITVPFLPDLHSDNTAAADASPITLVTDGTQLHNLHKDIFYIPDPSLVFVGVPYFTATFTLFEFQAMVAAKVLAGKVNLPSEKGMREEYENRVALKGYGKTFHSLREKEVEYVNELLAFANPQLDTQLLGHTEVWHGARAELVARMKAMFAGGNESAKELGVTCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CBI1</accession>
    <name>A0A177CBI1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_1187687</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG04696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035061.1">
        <property type="nucleotide sequence ID" value="XM_018180948.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CBI1"/>
    <dbReference type="STRING" id="1460663.A0A177CBI1"/>
    <dbReference type="GeneID" id="28764434"/>
    <dbReference type="InParanoid" id="A0A177CBI1"/>
    <dbReference type="OrthoDB" id="5426798at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF11">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="272"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="190"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="353"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="34"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="102"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="129"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="353"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="386"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAG04696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="923" mass="102585" checksum="522FD7A42537A0F6" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CCE0</accession>
    <name>A0A177CCE0_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">EGF-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_1248230</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG05314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035679.1">
        <property type="nucleotide sequence ID" value="XM_018184255.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CCE0"/>
    <dbReference type="STRING" id="1460663.A0A177CCE0"/>
    <dbReference type="GeneID" id="28767741"/>
    <dbReference type="InParanoid" id="A0A177CCE0"/>
    <dbReference type="OrthoDB" id="6130531at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00053">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08994">
        <property type="entry name" value="GH43_62_32_68_117_130-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23106">
        <property type="entry name" value="EGF_Teneurin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008057999" description="EGF-like domain-containing protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="3">
        <location>
            <begin position="17"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="44"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAG05314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="384" mass="43330" checksum="C496164D72058367" modified="2016-09-07" version="1">MYCRNSLLLAFLALLATTLACTKDDDCSLNGICKTNTTTTICHCDPGWTGPDCGRLDLAPATRWTGYNHTNYTDPAYYGAYGNSSWGGRIIQDRDDPKLFHLLVDQFSHGCGLGGWRPTSFIVRAESRSGPQGPYKWVQNVTSSFRHNADVLWSPADRKYLLWAIGAAVEDPKTCKSIPGSQFPNNVSVSSASSIRGPWTPFHITINGTNPAPWPLYSPANKTSQIALAVEDFKIFTAPDWNGAFTRVNEDVAWNTTDYSPTWTEDPFIWRDKRGNWHALAHWMIDIVEKNGTKYPRVGAHMFSRRLESGWTFKVQEAFSSTVEFTDGAVETFNRRERSKIFFDEDMRPLYLVSGVQAMGVKSSFTLVQPIGKRWREYEKELGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CCJ0</accession>
    <name>A0A177CCJ0_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">glutathione transferase</fullName>
            <ecNumber evidence="1">2.5.1.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CC84DRAFT_1206769</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>RX + glutathione = an S-substituted glutathione + a halide anion + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16042"/>
            <dbReference type="ChEBI" id="CHEBI:17792"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="EC" id="2.5.1.18"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.5.1.18" evidence="1"/>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG05353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035718.1">
        <property type="nucleotide sequence ID" value="XM_018182056.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CCJ0"/>
    <dbReference type="STRING" id="1460663.A0A177CCJ0"/>
    <dbReference type="GeneID" id="28765542"/>
    <dbReference type="InParanoid" id="A0A177CCJ0"/>
    <dbReference type="OrthoDB" id="249703at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043295">
        <property type="term" value="F:glutathione binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43900">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43900:SF3">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00043">
        <property type="entry name" value="GST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13417">
        <property type="entry name" value="GST_N_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST N-terminal" evidence="4">
        <location>
            <begin position="2"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="5">
        <location>
            <begin position="91"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00047960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAG05353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="225" mass="25339" checksum="07B18ADA4721639B" modified="2016-09-07" version="1">MPAFVLYGSRTSTNTMRVRLTLAEGNITDYELVLLNLLKGEQKSEEYKMRHPWGKVPTITFPDGFTLHESRAICKYLATKYSIPLLPPSSDAEATARFDEAQSVEIFYFADPVQKLAFEKFIKKFMTGGAPDEKVVADSLQALETYFDAAENLLQKRSYMACENYTLIDLYYIPLMLRLFAVGHGDLITSHKAVNAWYDRCLSRPATQRILAADKEAAAAADGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CCQ1</accession>
    <name>A0A177CCQ1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1246923</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG04662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035027.1">
        <property type="nucleotide sequence ID" value="XM_018184216.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CCQ1"/>
    <dbReference type="GeneID" id="28767702"/>
    <dbReference type="InParanoid" id="A0A177CCQ1"/>
    <dbReference type="OrthoDB" id="10549357at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG04662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="303" mass="33858" checksum="024F74981739DC7D" modified="2016-09-07" version="1">MPYHAPLRTASSLLPVYTALRAAQVPSLTYLFSLDEQIAHTELEELYARIVLLWQEMRGHYVEFCCLCADWCVGEVLGFVREVGESAKVWCAGVGNEWEDLGWSMEEERLISATSEVAACEEMSFCRITCISSEPVGQHFHYTKCLATHNKVLLSYYSQPAATFRMRVCVFVLGIAGLFISLSRSTPIRVPLSDDEPDALEKRSGTDGLWTWQKPQPVIGRYPDGRLICRIVTMTAGHTQGPCPPEVAPEAVAKLLHAQHCRQHCCMEDGAPCGENWHVHEGSAYKDKHTYTNGHGATIHDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CDD1</accession>
    <name>A0A177CDD1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_800995</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG04710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035075.1">
        <property type="nucleotide sequence ID" value="XM_018187470.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CDD1"/>
    <dbReference type="GeneID" id="28770956"/>
    <dbReference type="InParanoid" id="A0A177CDD1"/>
    <dbReference type="OrthoDB" id="422839at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG04710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="151" mass="16060" checksum="444855CD456528D9" modified="2016-09-07" version="1">MPPPVTRSSPSGPSRGGSRRRGTTRSGSAAPGSPHLSVPGSSRSTPASNTSTTTRSGQIVVPSLKARESQNARFADATESPMVIPPNEILVYAATTTGEDIPRTYAEAMSDTNALLWRPPIAHEIRAHETNRTYDIVNIEDLPLSIRLVGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CDK3</accession>
    <name>A0A177CDK3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_808541</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG04879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035244.1">
        <property type="nucleotide sequence ID" value="XM_018187499.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CDK3"/>
    <dbReference type="GeneID" id="28770985"/>
    <dbReference type="InParanoid" id="A0A177CDK3"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="76"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG04879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="187" mass="20583" checksum="0FC8F4C46A8CD6C7" modified="2016-09-07" version="1">MNKPSNRVVDPKAVPQIFTWLEDTVGRSAKRPRHWGLPKTITTNCESVPIARQRGADTHWPENWPQSDLNERHFSSDQPSSSSDSLMPVDGPPFNVMAAHLTEGVGDGQNGRSTGHAPSDCSSDRRTSLEEISIHPDKSLEDDNLGCQGSQGRDEGTDILGWLSLFGNVNELHPTDTVRDVLSSWSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CEM9</accession>
    <name>A0A177CEM9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Ketoacyl-synt-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CC84DRAFT_1206707</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG05259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035624.1">
        <property type="nucleotide sequence ID" value="XM_018182046.1"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CEM9"/>
    <dbReference type="GeneID" id="28765532"/>
    <dbReference type="InParanoid" id="A0A177CEM9"/>
    <dbReference type="OrthoDB" id="329835at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030639">
        <property type="term" value="P:polyketide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05274">
        <property type="entry name" value="KR_FAS_SDR_x"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013217">
        <property type="entry name" value="Methyltransf_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056501">
        <property type="entry name" value="NAD-bd_HRPKS_sdrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049551">
        <property type="entry name" value="PKS_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049552">
        <property type="entry name" value="PKS_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF22">
        <property type="entry name" value="SYNTHASE, PUTATIVE (JCVI)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23297">
        <property type="entry name" value="ACP_SdgA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08242">
        <property type="entry name" value="Methyltransf_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23114">
        <property type="entry name" value="NAD-bd_HRPKS_sdrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21089">
        <property type="entry name" value="PKS_DH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="8">
        <location>
            <begin position="6"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="9">
        <location>
            <begin position="914"/>
            <end position="1217"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="7">
        <location>
            <begin position="2050"/>
            <end position="2128"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="6">
        <location>
            <begin position="914"/>
            <end position="1052"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="6">
        <location>
            <begin position="1064"/>
            <end position="1217"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for dehydratase activity" evidence="6">
        <location>
            <position position="946"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for dehydratase activity" evidence="6">
        <location>
            <position position="1130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAG05259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="2139" mass="234185" checksum="8AD508B9FF94EE77" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CER8</accession>
    <name>A0A177CER8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cysteine proteinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CC84DRAFT_1145980</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG06113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036478.1">
        <property type="nucleotide sequence ID" value="XM_018176535.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CER8"/>
    <dbReference type="STRING" id="1460663.A0A177CER8"/>
    <dbReference type="GeneID" id="28760021"/>
    <dbReference type="InParanoid" id="A0A177CER8"/>
    <dbReference type="OrthoDB" id="424753at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004198">
        <property type="term" value="F:calcium-dependent cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00044">
        <property type="entry name" value="CysPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022684">
        <property type="entry name" value="Calpain_cysteine_protease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000169">
        <property type="entry name" value="Pept_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001300">
        <property type="entry name" value="Peptidase_C2_calpain_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10183">
        <property type="entry name" value="CALPAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10183:SF425">
        <property type="entry name" value="CALPAIN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00648">
        <property type="entry name" value="Peptidase_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00230">
        <property type="entry name" value="CysPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50203">
        <property type="entry name" value="CALPAIN_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00139">
        <property type="entry name" value="THIOL_PROTEASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0788">Thiol protease</keyword>
    <feature type="domain" description="Calpain catalytic" evidence="5">
        <location>
            <begin position="172"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="621"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="621"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="675"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="779"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="active site" evidence="2 3">
        <location>
            <position position="200"/>
        </location>
    </feature>
    <feature type="active site" evidence="2 3">
        <location>
            <position position="383"/>
        </location>
    </feature>
    <feature type="active site" evidence="2 3">
        <location>
            <position position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR622684-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAG06113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="860" mass="95874" checksum="1551E2DDFE98FAE3" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CF08</accession>
    <name>A0A177CF08_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">AA9 family lytic polysaccharide monooxygenase</fullName>
            <ecNumber evidence="5">1.14.99.56</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Endo-beta-1,4-glucanase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Glycosyl hydrolase 61 family protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CC84DRAFT_1090620</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Lytic polysaccharide monooxygenase (LMPO) that depolymerizes crystalline and amorphous polysaccharides via the oxidation of scissile alpha- or beta-(1-4)-glycosidic bonds, yielding C1 and/or C4 oxidation products. Catalysis by LPMOs requires the reduction of the active-site copper from Cu(II) to Cu(I) by a reducing agent and H(2)O(2) or O(2) as a cosubstrate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 5">
            <text>[(1-&gt;4)-beta-D-glucosyl]n+m + reduced acceptor + O2 = 4-dehydro-beta-D-glucosyl-[(1-&gt;4)-beta-D-glucosyl]n-1 + [(1-&gt;4)-beta-D-glucosyl]m + acceptor + H2O.</text>
            <dbReference type="EC" id="1.14.99.56"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 5">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="5">Has a modular structure: an endo-beta-1,4-glucanase catalytic module at the N-terminus, a linker rich in serines and threonines, and a C-terminal carbohydrate-binding module (CBM).</text>
    </comment>
    <dbReference type="EC" id="1.14.99.56" evidence="5"/>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG05926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036291.1">
        <property type="nucleotide sequence ID" value="XM_018174363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CF08"/>
    <dbReference type="STRING" id="1460663.A0A177CF08"/>
    <dbReference type="GeneID" id="28757849"/>
    <dbReference type="InParanoid" id="A0A177CF08"/>
    <dbReference type="OrthoDB" id="4849160at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008810">
        <property type="term" value="F:cellulase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030248">
        <property type="term" value="F:cellulose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd21175">
        <property type="entry name" value="LPMO_AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049892">
        <property type="entry name" value="AA9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005103">
        <property type="entry name" value="AA9_LPMO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353:SF19">
        <property type="entry name" value="GLYCOSYLHYDROLASE FAMILY 61-8 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03443">
        <property type="entry name" value="AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="4 5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Auxiliary Activity family 9 catalytic" evidence="6">
        <location>
            <begin position="14"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU368122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAG05926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="246" mass="27370" checksum="F5AF45933AE56971" modified="2016-09-07" version="1">MLGASWLAAQTSAHGGCLNYTVGDTWYPGYSPFDDQTFQDAAPWMVQRKWITNDPIFETTNISLSCNTPGTPARSSIPILPGQNITAVYMYWVHTVGPMIAWMARCTNDDCHTFDSSTADWFKIGERGLQDGTIELGNWFQKTFSNWDGSPSLWSETVPRGLKKGKYLVRHEIISLHSANKPQFYPECAHLDVGGEGSAEPGEEYLVKIPGVWSMNQPEINIDIYAPNVSNRTTYTIPGPPVWSGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CFD8</accession>
    <name>A0A177CFD8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_760532</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG06314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036679.1">
        <property type="nucleotide sequence ID" value="XM_018187330.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CFD8"/>
    <dbReference type="GeneID" id="28770816"/>
    <dbReference type="InParanoid" id="A0A177CFD8"/>
    <dbReference type="OrthoDB" id="3762345at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG06314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="331" mass="37755" checksum="17B650368EE01AFB" modified="2016-09-07" version="1">MLAMGTALSKDPARTPRAKLSLSSKKKRKIGNVSSTIARQSITWPKRIETGLEEIDQSLLELSLNSGADKRAQRCHWNKLPTELKLHVFSFLGIVMGDPVRHPATTGSRYHLETLRFRLVNKEFRTLYRDVWYKSNTFVVAPIWINPLEEDRPIFVYPAARNGHFIRKLQVELTLDWGHDGLEMLRCQTTDWCRLFRPRPHVSAFQDEHDKRDDKDDLGFDMNGGGYTRHCACGESCSLGTSTTDWQNHFQSLDELKISLRVTGFDGCSEGCTQSAHELIQMFTNSVRRLMIASEIIVSAKNVDVRVHCDCERVAAFVQSLVEGKIKKRCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CFE8</accession>
    <name>A0A177CFE8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1145034</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG05559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035924.1">
        <property type="nucleotide sequence ID" value="XM_018176489.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CFE8"/>
    <dbReference type="GeneID" id="28759975"/>
    <dbReference type="InParanoid" id="A0A177CFE8"/>
    <dbReference type="OrthoDB" id="5201563at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="39"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG05559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="123" mass="14022" checksum="5C327F5770C3A445" modified="2016-09-07" version="1">MSVTTTANAQTYNLRAVLADYDLHHTPETDPLDTTLNVHPSPNSPLSHSNPADWPTNERRVPPYRPINTELDQTQRRVYQNGVERAFVAVMFSGVFLESTASKLWRNTFGRFWNVGYNIGGEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CFL1</accession>
    <name>A0A177CFL1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Succinate dehydrogenase assembly factor 2, mitochondrial</fullName>
            <shortName evidence="4">SDH assembly factor 2</shortName>
            <shortName evidence="4">SDHAF2</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CC84DRAFT_1164676</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit of the SDH catalytic dimer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Interacts with the flavoprotein subunit within the SDH catalytic dimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the SDHAF2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG06403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036768.1">
        <property type="nucleotide sequence ID" value="XM_018178535.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CFL1"/>
    <dbReference type="STRING" id="1460663.A0A177CFL1"/>
    <dbReference type="GeneID" id="28762021"/>
    <dbReference type="InParanoid" id="A0A177CFL1"/>
    <dbReference type="OrthoDB" id="284292at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006121">
        <property type="term" value="P:mitochondrial electron transport, succinate to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034553">
        <property type="term" value="P:mitochondrial respiratory chain complex II assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.250:FF:000002">
        <property type="entry name" value="Succinate dehydrogenase assembly factor 2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.250">
        <property type="entry name" value="Flavinator of succinate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03057">
        <property type="entry name" value="SDHAF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005631">
        <property type="entry name" value="SDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036714">
        <property type="entry name" value="SDH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028882">
        <property type="entry name" value="SDHAF2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12469">
        <property type="entry name" value="PROTEIN EMI5 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12469:SF2">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE ASSEMBLY FACTOR 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03937">
        <property type="entry name" value="Sdh5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109910">
        <property type="entry name" value="YgfY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2 4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="55"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="214"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="283"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="55"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="214"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="234"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="289"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAG06403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="322" mass="35327" checksum="B2C9835AF0A1F8E4" modified="2016-09-07" version="1">MAHARLAIRSSRALLSLSQPARFFSVYAARCNEFEALNKRANDTADEYRRIQTSRPLNPHMTNTTSTIANEMPSVGKDAPPPELVTSVDPGFAPKDAVPENTERMTGGTQGSKSEDVSGSNKDLKGTNELGVGEMEGATFKVEPLRRTGEDENTMRARLLYQCRKRGTLESELLMSTFADANLATMTPSQLEQFDLFLDENDWDIYYWATQEPTPTSMETAEGQSGELATENAKGQEQDEQKRAPAKGEWAQTIGTFKPAYRPVPARWKDSEILTMLRNHVTSRSAGGAQEGGSKVGGKDLGQGTKGTGGLGMMPKIRHFDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CFR6</accession>
    <name>A0A177CFR6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_735552</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG05812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036177.1">
        <property type="nucleotide sequence ID" value="XM_018187231.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CFR6"/>
    <dbReference type="GeneID" id="28770717"/>
    <dbReference type="InParanoid" id="A0A177CFR6"/>
    <dbReference type="OrthoDB" id="5392263at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="211"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="245"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="392"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="427"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="553"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="604"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="753"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="870"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="767"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="816"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="833"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="870"/>
            <end position="879"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG05812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="905" mass="102674" checksum="B2F6D3E2A88B08E2" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CFS8</accession>
    <name>A0A177CFS8_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">beta-glucosidase</fullName>
            <ecNumber evidence="3">3.2.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CC84DRAFT_753632</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 14">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="3"/>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG06176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036541.1">
        <property type="nucleotide sequence ID" value="XM_018187304.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CFS8"/>
    <dbReference type="STRING" id="1460663.A0A177CFS8"/>
    <dbReference type="GeneID" id="28770790"/>
    <dbReference type="InParanoid" id="A0A177CFS8"/>
    <dbReference type="OrthoDB" id="2123594at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.300:FF:000007">
        <property type="entry name" value="Lysosomal beta glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000495">
        <property type="entry name" value="Periplasmic beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1700:FF:000009">
        <property type="entry name" value="Periplasmic beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051915">
        <property type="entry name" value="Cellulose_Degrad_GH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30620:SF117">
        <property type="entry name" value="BETA-1,4-XYLOSIDASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30620">
        <property type="entry name" value="PERIPLASMIC BETA-GLUCOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="Beta-D-glucan exohydrolase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008058131" description="beta-glucosidase" evidence="10">
        <location>
            <begin position="20"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type III-like" evidence="11">
        <location>
            <begin position="717"/>
            <end position="786"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OAG06176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="798" mass="85454" checksum="484AA58AFCA2D3D9" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CFU4</accession>
    <name>A0A177CFU4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Phenylacetaldoxime dehydratase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CC84DRAFT_765651</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG06484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036849.1">
        <property type="nucleotide sequence ID" value="XM_018187366.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CFU4"/>
    <dbReference type="GeneID" id="28770852"/>
    <dbReference type="InParanoid" id="A0A177CFU4"/>
    <dbReference type="OrthoDB" id="3359285at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025702">
        <property type="entry name" value="OXD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13816">
        <property type="entry name" value="Dehydratase_hem"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAG06484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="375" mass="42031" checksum="57043B2B13E8B4B4" modified="2016-09-07" version="1">MTCPMPLTRTYPLSKPPNHTLPVPRYTATLLSSTTHLHTLYIGLQTHSTSGAITAAAHQLQKHIQFWIDSTPELSHESESPLDLTYERFTLIDHAGGDPAGSKVWVCYQSFTTRGSSPPSPTFPDIDLPSLYKTIPEASRPAIGLWKESFTTPVGRLETNYSGTDYLPGLARIPGVRVAEHELATYWGAARDRIPEAGWDLFPRPDTGGMRTEVGDVDGRGHVFKGTNKANVVHIRSGQWWENCEDEERGAYEGKLEPTLRAGLSYLNSHREESGCMRIRYLRNGEGDEDVRETCGAGFFHNLEDLERWSKTHSSHLKIWRGALAHYKAFPENRRLRTWHEVSVIREGEARWEYMNCKGGTGVMGCVVLEGTPLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CFW0</accession>
    <name>A0A177CFW0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ornithine cyclodeaminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1259679</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ornithine cyclodeaminase/mu-crystallin family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG06504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036869.1">
        <property type="nucleotide sequence ID" value="XM_018184930.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CFW0"/>
    <dbReference type="FunCoup" id="A0A177CFW0">
        <property type="interactions" value="7"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CFW0"/>
    <dbReference type="GeneID" id="28768416"/>
    <dbReference type="InParanoid" id="A0A177CFW0"/>
    <dbReference type="OrthoDB" id="41492at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1780.10">
        <property type="entry name" value="ornithine cyclodeaminase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003462">
        <property type="entry name" value="ODC_Mu_crystall"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023401">
        <property type="entry name" value="ODC_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13812">
        <property type="entry name" value="KETIMINE REDUCTASE MU-CRYSTALLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13812:SF19">
        <property type="entry name" value="KETIMINE REDUCTASE MU-CRYSTALLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02423">
        <property type="entry name" value="OCD_Mu_crystall"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG06504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="364" mass="39437" checksum="539E4DD551852092" modified="2016-09-07" version="1">MFTVLSDKDIQRILQNLSHGELDGLTQALEKALIQYSTQNDHQYQPHRATITRPSGQVSLFMPATTESLVGVKIVGVAPSPDPSTLPPGTKPQAGLKSALTLCDDVGQAIGILNAAELTAFRTALGSMLLYKTRKRTEKIVVFGAGKQALWHVRLAVLLRGKDIMRVTIVNRSGQRAQELVETLTSDSGWPEHVTIGAVEQPESEELEKLVSEADVIFCTTPSRVPLILASFLTSESAREKSRYIAAIGSYRLDMAEIDPELLKKVADPSGEFSSQVWRGSITVDSREGCLQEAGELVSSGVAAENWLEVGAIKGDCSPEMDDWLKNGFVIYKSVGIGIMDLAVGSALLELARSKNIGLTVEDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CG40</accession>
    <name>A0A177CG40_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Developmental regulatory protein wetA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CC84DRAFT_1092599</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the wetA family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG06306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036671.1">
        <property type="nucleotide sequence ID" value="XM_018174468.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CG40"/>
    <dbReference type="STRING" id="1460663.A0A177CG40"/>
    <dbReference type="GeneID" id="28757954"/>
    <dbReference type="InParanoid" id="A0A177CG40"/>
    <dbReference type="OrthoDB" id="2575228at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048315">
        <property type="term" value="P:conidium formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040112">
        <property type="entry name" value="WetA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22934:SF25">
        <property type="entry name" value="DEVELOPMENTAL REGULATORY PROTEIN WETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22934">
        <property type="entry name" value="PROTEIN ESC1/WETA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0010">Activator</keyword>
    <keyword evidence="7" id="KW-0183">Conidiation</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0749">Sporulation</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="127"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="323"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="403"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="140"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="157"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="323"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="414"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="434"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAG06306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="520" mass="55842" checksum="D1E9F94B78721103" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CG43</accession>
    <name>A0A177CG43_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CC84DRAFT_1186890</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG05710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036075.1">
        <property type="nucleotide sequence ID" value="XM_018180886.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CG43"/>
    <dbReference type="STRING" id="1460663.A0A177CG43"/>
    <dbReference type="GeneID" id="28764372"/>
    <dbReference type="InParanoid" id="A0A177CG43"/>
    <dbReference type="OrthoDB" id="448448at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18008">
        <property type="entry name" value="DEXDc_SHPRH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050628">
        <property type="entry name" value="SNF2_RAD54_helicase_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626:SF22">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="4">
        <location>
            <begin position="186"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="5">
        <location>
            <begin position="604"/>
            <end position="756"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAG05710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="781" mass="88000" checksum="0D7858291B3CE664" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CGQ6</accession>
    <name>A0A177CGQ6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_750409</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG06132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036497.1">
        <property type="nucleotide sequence ID" value="XM_018187291.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CGQ6"/>
    <dbReference type="GeneID" id="28770777"/>
    <dbReference type="InParanoid" id="A0A177CGQ6"/>
    <dbReference type="OrthoDB" id="3680973at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG06132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="258" mass="29518" checksum="80890C7FCAA7EC1B" modified="2016-09-07" version="1">MSKSHLCLGEEMHMSAEEKEMARLRNMGDEKARAEAACHGRGRQERIRSGRTSRHLEIPLADHLPITNSTNRTRYRASHHSRCLRHQNPPLGPHRWPRKTYTSCLETRHKHNAYTYIPSRYGKVPNRMGEIQIPNDEVECLPEFDGNTKQKRSAKMIAALKKHHADGADSDFTIIDTYTGSSLLDWDIIIGYARPGICVDPEVRPLVRASLTNDDKITLYMPAGCGVDRNRVDGELLVAIRDIKVWKEFDAPIESRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CHA0</accession>
    <name>A0A177CHA0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1174849</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG06953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037318.1">
        <property type="nucleotide sequence ID" value="XM_018180116.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CHA0"/>
    <dbReference type="GeneID" id="28763602"/>
    <dbReference type="InParanoid" id="A0A177CHA0"/>
    <dbReference type="OrthoDB" id="2796277at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG06953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="158" mass="16870" checksum="592CECCCB3B759F3" modified="2016-09-07" version="1">MFSLMLGGGVVPTLYDTTASLKSKGLSGRGTPDKSKARKSSNDGPSSKTVRESGIFSLLRDIPVFQMVLWTSSQLQAGVAKSPWQLQALNTVTWVGTSGPFINFCHSAWSVVGETNNLMSSSKSFLPQRYDPSPWGPAGAVIEHGLAGAQTYPTPHKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CHL0</accession>
    <name>A0A177CHL0_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">TMEM205-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CC84DRAFT_1092211</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG06338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036703.1">
        <property type="nucleotide sequence ID" value="XM_018174440.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CHL0"/>
    <dbReference type="FunCoup" id="A0A177CHL0">
        <property type="interactions" value="83"/>
    </dbReference>
    <dbReference type="GeneID" id="28757926"/>
    <dbReference type="InParanoid" id="A0A177CHL0"/>
    <dbReference type="OrthoDB" id="1641132at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025423">
        <property type="entry name" value="TMEM205-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053009">
        <property type="entry name" value="Xanthocillin_Biosynth-Assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23241:SF106">
        <property type="entry name" value="DUF4149 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23241">
        <property type="entry name" value="LATE EMBRYOGENESIS ABUNDANT PLANTS LEA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13664">
        <property type="entry name" value="DUF4149"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="46"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="141"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="TMEM205-like" evidence="6">
        <location>
            <begin position="12"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAG06338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="172" mass="18885" checksum="59ECF000271588A9" modified="2016-09-07" version="1">MTSLASFKNPAAYGTLLGSTLFQSFIGGIVAFRALPRPMFSTLQKATFPAYFTLQTVTPALMALTYPGGPSALWTYKASGDGLAFWLTSTMFTTALVNLLYVGPETTRIMKVRKHQETKDGKKSYDKGPHSKEMEALNRQFGILHGVSSLVNLIGFLGMCWYGVLLGEGLRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CIN5</accession>
    <name>A0A177CIN5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_1204709</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG07121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037486.1">
        <property type="nucleotide sequence ID" value="XM_018181924.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CIN5"/>
    <dbReference type="STRING" id="1460663.A0A177CIN5"/>
    <dbReference type="GeneID" id="28765410"/>
    <dbReference type="InParanoid" id="A0A177CIN5"/>
    <dbReference type="OrthoDB" id="3642826at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008058352" evidence="3">
        <location>
            <begin position="32"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="582"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="183"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAG07121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="604" mass="60655" checksum="FEAF062E90F64A29" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CJ82</accession>
    <name>A0A177CJ82_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">IDI-2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1163693</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG07563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037928.1">
        <property type="nucleotide sequence ID" value="XM_018178319.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CJ82"/>
    <dbReference type="GeneID" id="28761805"/>
    <dbReference type="InParanoid" id="A0A177CJ82"/>
    <dbReference type="OrthoDB" id="3660930at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008058256" description="IDI-2" evidence="1">
        <location>
            <begin position="19"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG07563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="143" mass="15402" checksum="9549922F7FCB2E64" modified="2016-09-07" version="1">MKFTPILLFAASLASVSSTAIPDPQTLECGELGRMNIKPGDLPPNVHISDVRTCRDHPETTSVNKRKHDGTPAIFKRECNSSGKSKGCSKNGYCWKECGGGHQWCWVALAEGWGPWKTCSNDGQCKSSDSCAKGDCKDCGCSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CJI6</accession>
    <name>A0A177CJI6_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">methionyl-tRNA formyltransferase</fullName>
            <ecNumber evidence="1">2.1.2.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1143940</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.1.2.9" evidence="1"/>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG07421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037786.1">
        <property type="nucleotide sequence ID" value="XM_018176437.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CJI6"/>
    <dbReference type="FunCoup" id="A0A177CJI6">
        <property type="interactions" value="273"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CJI6"/>
    <dbReference type="GeneID" id="28759923"/>
    <dbReference type="InParanoid" id="A0A177CJI6"/>
    <dbReference type="OrthoDB" id="10268103at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004479">
        <property type="term" value="F:methionyl-tRNA formyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd08646">
        <property type="entry name" value="FMT_core_Met-tRNA-FMT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002376">
        <property type="entry name" value="Formyl_transf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036477">
        <property type="entry name" value="Formyl_transf_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041711">
        <property type="entry name" value="Met-tRNA-FMT_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11138">
        <property type="entry name" value="METHIONYL-TRNA FORMYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11138:SF5">
        <property type="entry name" value="METHIONYL-TRNA FORMYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00551">
        <property type="entry name" value="Formyl_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53328">
        <property type="entry name" value="Formyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Formyl transferase N-terminal" evidence="2">
        <location>
            <begin position="32"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG07421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="367" mass="39928" checksum="A308C210731D0DF8" modified="2016-09-07" version="1">MLWRLPAPVRSFLAPGYRRFISTAATTAPPLRILFCGSDDFSIASLRALSQAQREVPKLIESIDVVHRPAKPTGRGLKSLRDVPIKLAAAEELCVTHTIDTFTGWTPPSRVDLIIAVSFGLFVPPRILSLAKYGGLNVHPSLLPDLKGPAPIQHALLKRRQATGVSVQTLHPTQFDGGTILAQTPSPGISIPDWVDADGLTRRLGHEGANMLVNVLLSRAFVPPLKDVGWYGDSGGAIDHAGKILKGDQQVDFAKSTLDDVFAIKRAIGEPWCWLPNGDRLILNEFSEKKVLLGEQGQEHPPGRMWLDTSRAPKHNVPLARMACGRILQIDKSSIGGRPVGAGNQRLVSMLRQQRTDTVAMDEGTQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2023-06-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CJP6</accession>
    <name>A0A177CJP6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_708658</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG07745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038110.1">
        <property type="nucleotide sequence ID" value="XM_018187130.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CJP6"/>
    <dbReference type="GeneID" id="28770616"/>
    <dbReference type="InParanoid" id="A0A177CJP6"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG07745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="121" mass="12999" checksum="B4940C8F49688D3F" modified="2016-09-07" version="1">MRAGTPNACDVARPSLDSVPTRLAWPAGTEAKSPAPAPSPGEVRGRKASIIYWRGAEKNDNGPLWGSVSCHDMCKSRCWGAKLTYTDRALDLHQQCSDGRLHASSTLWQGPVRASGPTALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CJQ1</accession>
    <name>A0A177CJQ1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cnl2/NKP2 family protein-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1216073</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG07069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037434.1">
        <property type="nucleotide sequence ID" value="XM_018182764.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CJQ1"/>
    <dbReference type="STRING" id="1460663.A0A177CJQ1"/>
    <dbReference type="GeneID" id="28766250"/>
    <dbReference type="InParanoid" id="A0A177CJQ1"/>
    <dbReference type="OrthoDB" id="2311687at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031511">
        <property type="term" value="C:Mis6-Sim4 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018565">
        <property type="entry name" value="Nkp2/Cnl2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28064">
        <property type="entry name" value="INNER KINETOCHORE SUBUNIT NKP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28064:SF1">
        <property type="entry name" value="INNER KINETOCHORE SUBUNIT NKP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09447">
        <property type="entry name" value="Cnl2_NKP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="119"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG07069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="191" mass="21336" checksum="3A5F42CA5E6ADCAF" modified="2016-09-07" version="1">MPSTEAKLLSDFLVAPASLRDFMTLRQFTDIFPKGHRSNPAVKELHRELCTLRERDIDAVRQDIALEVKRSKQLRRDYARERRQVDEANVVGLDPVALRMEQELSGAHGRKPHTLQTVHASIEEACEALEAQIADIEQENRAALLEVEDTISALSDLRKGSFPQTASGEDIGQEVLATLKRLEAVCLEPAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CKP9</accession>
    <name>A0A177CKP9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1256842</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG07876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038241.1">
        <property type="nucleotide sequence ID" value="XM_018184671.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CKP9"/>
    <dbReference type="GeneID" id="28768157"/>
    <dbReference type="InParanoid" id="A0A177CKP9"/>
    <dbReference type="OrthoDB" id="3790861at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="250"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="290"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="365"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="220"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="293"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="311"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="367"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG07876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="489" mass="53239" checksum="0306A14B5BFB0CDC" modified="2016-09-07" version="1">MSTDSKKQNKKERLRRLLSQPFLRSRLPCLPEEPAAMPPTIAPDAADLLEQVQETIARIQKANPQTITNANKATIRDRIDDADLLALEKKDLDAKVAALKASNVYQADYLKLGSRWSPNSTETELSTRAPIEDVPSDEEPEICEADVAIVYPVKKIPAGTVKLVGTGAPALNRRQREEEARPQTKNVVSFQGIRASKAADKDAFEKTLHRKRSSDDLRRGKAHLAHKKSTGPLPAYLDYFEEEERKKILDIPRDAPSTSPRARGTQHGDVNECPQSSACTQDFTAERAIPPVSLQQSALSTTRLPPKSPKRAPPIAPMMPLRTPPPPPIPIKSAYRPSGVPSSTAVPLPTSPVPPFCIAPVRGKPLSPSTRSPLSQATMTASPSTIQRNAPPRIQLPVPGPNAALPRSSSLQAPMRQECDEGQHTFRPINLNAARMASAYHCTGSTENTDGPACCEKCGREVEVCMQCEVPVCSLAACYDCANIMKEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CKX6</accession>
    <name>A0A177CKX6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Actin-like ATPase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1185124</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the actin family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038550.1">
        <property type="nucleotide sequence ID" value="XM_018180785.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CKX6"/>
    <dbReference type="FunCoup" id="A0A177CKX6">
        <property type="interactions" value="802"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CKX6"/>
    <dbReference type="GeneID" id="28764271"/>
    <dbReference type="InParanoid" id="A0A177CKX6"/>
    <dbReference type="OrthoDB" id="5572108at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031011">
        <property type="term" value="C:Ino80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034080">
        <property type="term" value="P:CENP-A containing chromatin assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd10206">
        <property type="entry name" value="ASKHA_NBD_Arp8-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000232">
        <property type="entry name" value="Actin-related protein 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.580:FF:000004">
        <property type="entry name" value="Actin-related protein 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="65"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="516"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="65"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="519"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG08185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="718" mass="80782" checksum="BA0B8F63EEC51B2B" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2023-06-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CLD1</accession>
    <name>A0A177CLD1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_703459</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG07629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037994.1">
        <property type="nucleotide sequence ID" value="XM_018187109.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CLD1"/>
    <dbReference type="GeneID" id="28770595"/>
    <dbReference type="InParanoid" id="A0A177CLD1"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG07629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="82" mass="9240" checksum="461814A47D0DAE96" modified="2016-09-07" version="1">MRRGARNGIYSHRVATLRFASYGGFRLYRMLRNPRTGSIYVVCTVAVSLPCHFDNYNILSQHYCICAECDVACSVDALAGWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CMS3</accession>
    <name>A0A177CMS3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1240371</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039178.1">
        <property type="nucleotide sequence ID" value="XM_018184017.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CMS3"/>
    <dbReference type="STRING" id="1460663.A0A177CMS3"/>
    <dbReference type="GeneID" id="28767503"/>
    <dbReference type="InParanoid" id="A0A177CMS3"/>
    <dbReference type="OrthoDB" id="3944737at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="362"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="373"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="401"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="419"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG08813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="431" mass="48683" checksum="7087A8B65CCAA3DA" modified="2016-09-07" version="1">MAQTLLDYLRQQNPTLGQIHHKSGSTNTKNSQYKVPQRVARWEGFDSGTLQKMYPILLNRVRTRDALGFRPVDLQVKGENGGFSDVVYCWNREIVVRALEETREYIRHGDLVYMVRGEKARHPQGATKGFRPDWAAILLDADGKARGSSPTNFLPGETKYSEKWRSAWVEVGDFKHMFNSQNELPEWFKPLAQVFTYCYHLKTRYAYIITDEELVLFRVGPSEDGPEPSPTTWQCEVEALRFHGKIEFVSVPWINGRSEEGVELGGPNELSVNTALWWIHLQAAHKNSIEWTYPSLEEEILAIQDSFRLEDDVMFPRNDSCGASAVYTPTERAASDASDILPSFVVGQETAQFAIPRSSAASYGLRSRRRNAGRNQATSSFGSDAPNTSFVSHSSITSNKNRVKKPKAKISKRGRPERSNSGNNRGNSKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CNK5</accession>
    <name>A0A177CNK5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Hyoscyamine 6-dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_1142294</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG09084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039449.1">
        <property type="nucleotide sequence ID" value="XM_018176360.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CNK5"/>
    <dbReference type="STRING" id="1460663.A0A177CNK5"/>
    <dbReference type="GeneID" id="28759846"/>
    <dbReference type="InParanoid" id="A0A177CNK5"/>
    <dbReference type="OrthoDB" id="288590at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044283">
        <property type="term" value="P:small molecule biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050231">
        <property type="entry name" value="Iron_ascorbate_oxido_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47990">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00682">
        <property type="entry name" value="IPNSYNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="3">
        <location>
            <begin position="183"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAG09084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="351" mass="39073" checksum="E1998B0220C68651" modified="2016-09-07" version="1">MVGVGEAPPILDFSAFYTGDAAAKKKLVDDVRSCCLHNGFFQITGHNVPRELQQGIMDWNKKFFDLPLEQKMEVSKDTTNTWNRGYELLKSQILEEGTLPELKEGFYIGDEISKSHPYFINKKLNSGPNMWPSPSTLPEVADFQKTALAYYYQVVDLAKDILKVLAQTLDLEESWFDEFSEGAVATMRLLHYPSQPPDSPQKLTRGIGAHTDFGTITILLQDKVAGLQVLDNQTKEWLDVEPTPGAFVVNLGNLMMRWSNDKYISNTHRVINQSGEERYSIPVFFSGNPDFVVECLPNCRAEGEEAKYAPITVEQAVLGGYADSYGRAERFKKDAAAKASAVPSAQGVAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CNM2</accession>
    <name>A0A177CNM2_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_580881</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038883.1">
        <property type="nucleotide sequence ID" value="XM_018186756.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CNM2"/>
    <dbReference type="GeneID" id="28770242"/>
    <dbReference type="InParanoid" id="A0A177CNM2"/>
    <dbReference type="OrthoDB" id="3942472at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG08518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="327" mass="38555" checksum="CC951FD3B7E40B69" modified="2016-09-07" version="1">MSAAPTTPRYTRPTAAWQTRVTPERSSVRYPARPHLKRPPRLLLMSPRDPTQPCLFSRLPRELRLQIYECVLPRDLFLAPASGKYMCGMKERFKPALLHVCGLVRLEVATLLYGSTRITYKLTNFDFRPFEQWVTTIPKEHVNYMSRNKNLIMDLSGHIFPPITKKRFELCDTFGNRYLIPKGNSYNQFINFCLLAHWTQWCGNHSIPKKLHWNYRFGINTEFGSEADTFSVLRSFHKWFSSYLWTIAQPNVQNAWLRNVRRRTMKRELQKMLESIERAWRVHHTRMEDTKDADTRKSVSYSASAYASLRDDWATRVAIVKEVISSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CNT7</accession>
    <name>A0A177CNT7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Galactokinase</fullName>
            <ecNumber evidence="3">2.7.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Galactose kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CC84DRAFT_1114889</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>alpha-D-galactose + ATP = alpha-D-galactose 1-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13553"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28061"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58336"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.6"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:13554"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate metabolism; galactose metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GHMP kinase family. GalK subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.6" evidence="3"/>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038792.1">
        <property type="nucleotide sequence ID" value="XM_018175409.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CNT7"/>
    <dbReference type="FunCoup" id="A0A177CNT7">
        <property type="interactions" value="1027"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CNT7"/>
    <dbReference type="GeneID" id="28758895"/>
    <dbReference type="InParanoid" id="A0A177CNT7"/>
    <dbReference type="OrthoDB" id="187738at2759"/>
    <dbReference type="UniPathway" id="UPA00214"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004335">
        <property type="term" value="F:galactokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006012">
        <property type="term" value="P:galactose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000411">
        <property type="term" value="P:positive regulation of transcription by galactose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016126">
        <property type="term" value="P:sterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1440.340:FF:000003">
        <property type="entry name" value="GAL1p Galactokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000056">
        <property type="entry name" value="GAL1p Galactokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.3170:FF:000002">
        <property type="entry name" value="Galactokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000705">
        <property type="entry name" value="Galactokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019741">
        <property type="entry name" value="Galactokinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019539">
        <property type="entry name" value="GalKase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013750">
        <property type="entry name" value="GHMP_kinase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006203">
        <property type="entry name" value="GHMP_knse_ATP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006206">
        <property type="entry name" value="Mevalonate/galactokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00131">
        <property type="entry name" value="gal_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10457:SF7">
        <property type="entry name" value="GALACTOKINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10457">
        <property type="entry name" value="MEVALONATE KINASE/GALACTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10509">
        <property type="entry name" value="GalKase_gal_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08544">
        <property type="entry name" value="GHMP_kinases_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000530">
        <property type="entry name" value="Galactokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00473">
        <property type="entry name" value="GALCTOKINASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00959">
        <property type="entry name" value="MEVGALKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="GHMP Kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00106">
        <property type="entry name" value="GALACTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00627">
        <property type="entry name" value="GHMP_KINASES_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="10" id="KW-0299">Galactose metabolism</keyword>
    <keyword evidence="7 19" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="9" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="11" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Galactokinase N-terminal" evidence="18">
        <location>
            <begin position="30"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP kinase N-terminal" evidence="16">
        <location>
            <begin position="129"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP kinase C-terminal" evidence="17">
        <location>
            <begin position="410"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00029590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF08544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF10509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="OAG08427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="518" mass="56931" checksum="E716B4FE26B1EF1B" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CP56</accession>
    <name>A0A177CP56_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Hypervirulence associated protein TUDOR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1185669</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039356.1">
        <property type="nucleotide sequence ID" value="XM_018180815.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CP56"/>
    <dbReference type="STRING" id="1460663.A0A177CP56"/>
    <dbReference type="GeneID" id="28764301"/>
    <dbReference type="InParanoid" id="A0A177CP56"/>
    <dbReference type="OrthoDB" id="3360421at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021331">
        <property type="entry name" value="Hva1_TUDOR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11160">
        <property type="entry name" value="Hva1_TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hypervirulence associated protein TUDOR" evidence="2">
        <location>
            <begin position="251"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG08991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="312" mass="34472" checksum="A166A113D2A57323" modified="2016-09-07" version="1">MPSKDEKYTDPELRNEVKEEIQASDKGGAPGQWSARKAQMMASEYKKRGGGYTTDKKDEKAQHLDNWTEEDWQTKEGGGKAKQEDGTETRYLPKKAWEQMSEAEKEETDQKKQQGSKEGNQYVANTSKAKSARKHASKDTENANGKPNMKDAQSCTHHWEDEEHLKNGQKAYQEFKEQNKKDGAASVEAQSDSGSAHSDDQEHPTPKKRGRGANASGSNKKQKTSGGSDERNGSAGDKNPAGDKNRVPQVGQKVQWKALPGYVDGEVVEVAYEEKTVEGKAVKASKEDPRIVLKSSSSGKIAVHKPEAVYFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CQ40</accession>
    <name>A0A177CQ40_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">uS12 prolyl 3,4-dihydroxylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CC84DRAFT_1162851</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>[ribosomal protein uS12]-(3S)-3-hydroxy-L-proline + 2-oxoglutarate + O2 = [ribosomal protein uS12]-(3S)-3,4-dihydroxy-L-proline + succinate + CO2</text>
            <dbReference type="Rhea" id="RHEA:54160"/>
            <dbReference type="Rhea" id="RHEA-COMP:13817"/>
            <dbReference type="Rhea" id="RHEA-COMP:13818"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:85428"/>
            <dbReference type="ChEBI" id="CHEBI:138052"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>[ribosomal protein uS12]-L-proline + 2-oxoglutarate + O2 = [ribosomal protein uS12]-(3S)-3-hydroxy-L-proline + succinate + CO2</text>
            <dbReference type="Rhea" id="RHEA:54156"/>
            <dbReference type="Rhea" id="RHEA-COMP:13816"/>
            <dbReference type="Rhea" id="RHEA-COMP:13818"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:50342"/>
            <dbReference type="ChEBI" id="CHEBI:85428"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TPA1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG09068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039433.1">
        <property type="nucleotide sequence ID" value="XM_018178113.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CQ40"/>
    <dbReference type="FunCoup" id="A0A177CQ40">
        <property type="interactions" value="383"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CQ40"/>
    <dbReference type="GeneID" id="28761599"/>
    <dbReference type="InParanoid" id="A0A177CQ40"/>
    <dbReference type="OrthoDB" id="430522at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031418">
        <property type="term" value="F:L-ascorbic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019826">
        <property type="term" value="F:oxygen sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031543">
        <property type="term" value="F:peptidyl-proline dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008143">
        <property type="term" value="F:poly(A) binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140311">
        <property type="term" value="F:protein sequestering activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071456">
        <property type="term" value="P:cellular response to hypoxia"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000639">
        <property type="term" value="P:negative regulation of SREBP signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000288">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032436">
        <property type="term" value="P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006450">
        <property type="term" value="P:regulation of translational fidelity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006449">
        <property type="term" value="P:regulation of translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006415">
        <property type="term" value="P:translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.620:FF:000014">
        <property type="entry name" value="Prolyl 3,4-dihydroxylase TPA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.20">
        <property type="entry name" value="Oxoglutarate/iron-dependent oxygenase, C-terminal degradation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019601">
        <property type="entry name" value="Oxoglutarate/Fe-dep_Oase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006620">
        <property type="entry name" value="Pro_4_hyd_alph"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043044">
        <property type="entry name" value="TPA1/Ofd1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039558">
        <property type="entry name" value="TPA1/OFD1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051842">
        <property type="entry name" value="uS12_prolyl_hydroxylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12117">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE COMPLEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12117:SF0">
        <property type="entry name" value="PROLYL 3-HYDROXYLASE OGFOD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13661">
        <property type="entry name" value="2OG-FeII_Oxy_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10637">
        <property type="entry name" value="Ofd1_CTDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00702">
        <property type="entry name" value="P4Hc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0847">Vitamin C</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="14">
        <location>
            <begin position="134"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="483"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="496"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00051966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00081607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OAG09068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="642" mass="71804" checksum="D139D1380726260C" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CQQ9</accession>
    <name>A0A177CQQ9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mitochondrial division protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CC84DRAFT_1255795</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Involved in mitochondrial fission. Acts as an adapter protein required to form mitochondrial fission complexes. Formation of these complexes is required to promote constriction and fission of the mitochondrial compartment at a late step in mitochondrial division.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the WD repeat MDV1/CAF4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG09853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040218.1">
        <property type="nucleotide sequence ID" value="XM_018184571.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CQQ9"/>
    <dbReference type="FunCoup" id="A0A177CQQ9">
        <property type="interactions" value="84"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CQQ9"/>
    <dbReference type="GeneID" id="28768057"/>
    <dbReference type="InParanoid" id="A0A177CQQ9"/>
    <dbReference type="OrthoDB" id="496at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000266">
        <property type="term" value="P:mitochondrial fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016559">
        <property type="term" value="P:peroxisome fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22881">
        <property type="entry name" value="Mdv1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000881">
        <property type="entry name" value="Mitochondrial division protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.280.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19855:SF28">
        <property type="entry name" value="CCR4-ASSOCIATED FACTOR 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19855">
        <property type="entry name" value="WD40 REPEAT PROTEIN 12, 37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 11" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="328"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="370"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="453"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="537"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="560"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="409"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="236"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="417"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00039789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00043913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OAG09853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="678" mass="74544" checksum="F6D11FD597A9377E" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CRC4</accession>
    <name>A0A177CRC4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1160501</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG09327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039692.1">
        <property type="nucleotide sequence ID" value="XM_018177512.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CRC4"/>
    <dbReference type="GeneID" id="28760998"/>
    <dbReference type="InParanoid" id="A0A177CRC4"/>
    <dbReference type="OrthoDB" id="3029913at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG09327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="921" mass="101398" checksum="A4EC7F0E96844ADD" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CRZ8</accession>
    <name>A0A177CRZ8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1202790</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040668.1">
        <property type="nucleotide sequence ID" value="XM_018181792.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CRZ8"/>
    <dbReference type="GeneID" id="28765278"/>
    <dbReference type="InParanoid" id="A0A177CRZ8"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG10303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="102" mass="10962" checksum="2AE9461B6FFEA9D3" modified="2016-09-07" version="1">MLRSRALVLAIIGGKTCGRETGICRASQPHSKGTPYRSTLGVELKAIRSMTVLSNCAGSSKVERRRKLAEAGRGGDPQDSDNFPDNHQPSSASCYCNKHGRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CS44</accession>
    <name>A0A177CS44_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_482286</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040718.1">
        <property type="nucleotide sequence ID" value="XM_018186444.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CS44"/>
    <dbReference type="GeneID" id="28769930"/>
    <dbReference type="InParanoid" id="A0A177CS44"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG10353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="224" mass="24648" checksum="E4BF8D4D4D446498" modified="2016-09-07" version="1">MHASTLGRGFATTARFCHTSPLSAAVGRAPMLPVALPDLHPTSGRGCDPLRCILPKVPWLCSPNGCEFAHQTPALTHAYVARWQVVRLYPLRTILRLPRKQLDAARHTLGTPRATCNLALEHLRASSCPSSSRNIVFLISDHARNTGLGVLAREPFWKIRPTVSYEEFEHSILKNVIEARQLPEINHLAANSESVQDAASSKASTADAPHFTMRFLALLPCHLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CSH2</accession>
    <name>A0A177CSH2_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Mid2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_1213802</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040848.1">
        <property type="nucleotide sequence ID" value="XM_018182570.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CSH2"/>
    <dbReference type="GeneID" id="28766056"/>
    <dbReference type="InParanoid" id="A0A177CSH2"/>
    <dbReference type="OrthoDB" id="3795887at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd12087">
        <property type="entry name" value="TM_EGFR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.510">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051694">
        <property type="entry name" value="Immunoregulatory_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549:SF26">
        <property type="entry name" value="AXIAL BUDDING PATTERN PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549">
        <property type="entry name" value="PAIRED IMMUNOGLOBULIN-LIKE TYPE 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008058535" description="Mid2 domain-containing protein" evidence="7">
        <location>
            <begin position="20"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="228"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="166"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="259"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="168"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="279"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="322"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAG10483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="371" mass="39476" checksum="3A5F7BFED21265F9" modified="2016-09-07" version="1">MLKLLQFALFLEVFARVGASPVDATFDAAHPTITQRAELFVREAPLSLVGYYTITDADGNVWITSSEKPGSVATFRGSTLVDWCNEGSEYLSATCPSAYWTSCDGSTLMSEGGSSPCTGTSTCDYDIIYTGSEIDTTSSLRWYHCIDRTYLQFYRDVPPGTLIEDVTSTDATSTESSSESSSDSSTTETTASPASPGTSLASQTSDSTSSPTPTSSTEPVKEKEPSKAWIAGVVIGIVGLLAVAGMGFYLWRRRNSQGYGPAPQGPPTGQPQAHMQSGYPPQQAAYYPPQQAYGNGPSPYLQPVSPNMGAYDAQTAKPQDNTMYGGYAAQQYGGPPPGVGTVQMPQPNPQVQPQMAANVHELPELAPSSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CSP9</accession>
    <name>A0A177CSP9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_1172944</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040920.1">
        <property type="nucleotide sequence ID" value="XM_018180002.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CSP9"/>
    <dbReference type="GeneID" id="28763488"/>
    <dbReference type="InParanoid" id="A0A177CSP9"/>
    <dbReference type="OrthoDB" id="424974at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053230">
        <property type="entry name" value="Trans_reg_galc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47654:SF5">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47654">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="3">
        <location>
            <begin position="311"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="16"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="93"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="400"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="769"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="93"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="405"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAG10555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="790" mass="87804" checksum="863E977F5F56005F" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CTQ4</accession>
    <name>A0A177CTQ4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CC84DRAFT_489785</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040936.1">
        <property type="nucleotide sequence ID" value="XM_018186484.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CTQ4"/>
    <dbReference type="GeneID" id="28769970"/>
    <dbReference type="InParanoid" id="A0A177CTQ4"/>
    <dbReference type="OrthoDB" id="508119at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000026">
        <property type="entry name" value="MFS quinate transporter QutD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF21">
        <property type="entry name" value="QUINATE TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G06960)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="45"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="119"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="149"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="178"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="209"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="303"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="345"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="372"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="404"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="442"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="474"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="41"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAG10571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="549" mass="59958" checksum="BD57193E2BF27D47" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CUF3</accession>
    <name>A0A177CUF3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RBR-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CC84DRAFT_1047161</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.31"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.3.2.31" evidence="2"/>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040782.1">
        <property type="nucleotide sequence ID" value="XM_018173426.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CUF3"/>
    <dbReference type="STRING" id="1460663.A0A177CUF3"/>
    <dbReference type="GeneID" id="28756912"/>
    <dbReference type="InParanoid" id="A0A177CUF3"/>
    <dbReference type="OrthoDB" id="1431934at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20335">
        <property type="entry name" value="BRcat_RBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20336">
        <property type="entry name" value="Rcat_RBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031127">
        <property type="entry name" value="E3_UB_ligase_RBR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002867">
        <property type="entry name" value="IBR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11685">
        <property type="entry name" value="RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01485">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22191">
        <property type="entry name" value="IBR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00647">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="11">
        <location>
            <begin position="1"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="10">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OAG10417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="219" mass="24578" checksum="FF6D4D17C9DB8F9E" modified="2016-09-07" version="1" fragment="single">CTVCSDSIHIADIPLLSGCSHQAATCVECFARWIESQLTTQGWKGIKCPDVSCSVILTHHDVQAYATPEVFSQYDMFSMRDALGQVSNFRWCRNPACTSGQEHDDDGYIFTCVACGHKACVTHDVNWHEGETCDEYTYRVSGAKEREQKAQEEASVAAISKLSKKCPGPDCAFNIEKNAGCDHMTCSRCRYEFCWECLADYQRIRTKGNAAHEKTCKYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CUH7</accession>
    <name>A0A177CUH7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CC84DRAFT_1191833</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG11205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041570.1">
        <property type="nucleotide sequence ID" value="XM_018181212.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CUH7"/>
    <dbReference type="STRING" id="1460663.A0A177CUH7"/>
    <dbReference type="GeneID" id="28764698"/>
    <dbReference type="InParanoid" id="A0A177CUH7"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11062">
        <property type="entry name" value="CYP58-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF156">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0349">Heme</keyword>
    <keyword evidence="4 5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="3 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="467"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAG11205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="524" mass="58293" checksum="3F470BDBDE683905" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CUI1</accession>
    <name>A0A177CUI1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Elongator complex protein 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_1161368</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ELP6 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040784.1">
        <property type="nucleotide sequence ID" value="XM_018177715.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CUI1"/>
    <dbReference type="GeneID" id="28761201"/>
    <dbReference type="InParanoid" id="A0A177CUI1"/>
    <dbReference type="OrthoDB" id="9995306at2759"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033588">
        <property type="term" value="C:elongator holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19495">
        <property type="entry name" value="Elp6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018627">
        <property type="entry name" value="ELP6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16184">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16184:SF6">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="110"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAG10419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="344" mass="36207" checksum="BE238396FDB44FDD" modified="2016-09-07" version="1">MPPTSRIPPLLQPFVRTPKNESLLLLTSTLDASANWLLTRFLCDALGSGQKDNDNGGAKNVVLVSWMRDYEFWRQEARKGSGLDLVGLRTQGRFAFVDGLSSLFLPADEDAADPQRPRSLPAAQPGVPSTKGLPTLPVRGPPGRTAPATAQAALRAPASHPGLYALSSTSIDQIKTAITAAIASLRPTTAAATRTLIILDNPDILLASVPGLTPAALTSFFLDLHTQATVSHVLVHLQSDLALLATTAEKPSPLQIAQQNLVVKTAHMSAKVLGVRVLDTGVARDVSGVLRVTANRESWAGIATLGEEEGGAVQAPEEAGSEVLYKVNGDGSVRVFERGADVAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CUI3</accession>
    <name>A0A177CUI3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Mso1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1161697</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041226.1">
        <property type="nucleotide sequence ID" value="XM_018177810.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CUI3"/>
    <dbReference type="GeneID" id="28761296"/>
    <dbReference type="InParanoid" id="A0A177CUI3"/>
    <dbReference type="OrthoDB" id="2683368at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028095">
        <property type="entry name" value="Mso1_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14475">
        <property type="entry name" value="Mso1_Sec1_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mso1 N-terminal" evidence="2">
        <location>
            <begin position="19"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="101"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="145"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="183"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="241"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG10861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="285" mass="30417" checksum="D27313543ADFF318" modified="2016-09-07" version="1">MSNYLNNLLTTTTSKYNTLRRTLLSDEADGDTEDDSHIARALRAYYTEKGRPFPQWLPPDPKAPQAAPVQMVSSAGRGYGQMGQQQPMTGRGGGLGDLWDSPSQAAPQQQEPMSLRRAQGRGGGGLRAHNSLSPEPQMQGRPLPSQRAGSQQSASSFRNELAPQTTGGSATSAQDRLKARLWGSGKSQNPSSSQNPSPTTSPAPSGGMRSQYDRPQAGGGRAPYPDDRGSTGGYSGGGRPQNYNMSANSPWSGGNDDPYGPSYNSAPPQQPERRRMGLPNGPRMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CUJ2</accession>
    <name>A0A177CUJ2_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein PNG1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Protein png1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_1237197</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transglutaminase-like superfamily. PNGase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040822.1">
        <property type="nucleotide sequence ID" value="XM_018183892.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CUJ2"/>
    <dbReference type="FunCoup" id="A0A177CUJ2">
        <property type="interactions" value="85"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CUJ2"/>
    <dbReference type="GeneID" id="28767378"/>
    <dbReference type="InParanoid" id="A0A177CUJ2"/>
    <dbReference type="OrthoDB" id="409136at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000224">
        <property type="term" value="F:peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006516">
        <property type="term" value="P:glycoprotein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.620.30:FF:000004">
        <property type="entry name" value="Peptidase (PNG1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.10:FF:000011">
        <property type="entry name" value="peptide-N(4)-(N-acetyl-beta- glucosaminyl)asparagine amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.620.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050883">
        <property type="entry name" value="PNGase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002931">
        <property type="entry name" value="Transglutaminase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12143">
        <property type="entry name" value="PEPTIDE N-GLYCANASE PNGASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12143:SF19">
        <property type="entry name" value="PEPTIDE-N(4)-(N-ACETYL-BETA-GLUCOSAMINYL)ASPARAGINE AMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01841">
        <property type="entry name" value="Transglut_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00460">
        <property type="entry name" value="TGc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Transglutaminase-like" evidence="7">
        <location>
            <begin position="230"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="403"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="9"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00071430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00071953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAG10457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="442" mass="50370" checksum="0A4645125872A829" modified="2016-09-07" version="1">MEHSHGASRPTTAHQDANQLATELTERFRQVLSTKRMNELTSRSVQSRSASPAPRDFGTPQPPPVQNAPPSYSSLRNIPLVPEPPQDARSLRFKNMLHSLSNMPLRWENPGLLDEALRVVPLEQIYSEAEEESQILQAEAESLGAGKKAAWGYQDCVVRALMRWFKRSFFSWVNNPPCGRCYSPTIGVGMAAPLPDEQARGANQVELYKCSLEHCGAYERYPRYNDAFVLLQTRRGRCGEWANCFSMLCRAVGSRVRWVWNAEDHVWTEVYSVHRKRWVHVDVCEEAWDKPLLYTQGWGKKLSYCIAFSADGAMDVTRRYVRDATKYSAERTRAPEAVLHHIMTEIRNMRRNNMGKQEKFRLEGEDMREDRELRTYVITSIAQSVSKINADDIISGRVTARADPDAPKALEGRTSGNAQWIRSRGEQGRGTPGQDPHNQHPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CVM7</accession>
    <name>A0A177CVM7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">UBC core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CC84DRAFT_1079240</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG11624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041989.1">
        <property type="nucleotide sequence ID" value="XM_018173834.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CVM7"/>
    <dbReference type="STRING" id="1460663.A0A177CVM7"/>
    <dbReference type="GeneID" id="28757320"/>
    <dbReference type="InParanoid" id="A0A177CVM7"/>
    <dbReference type="OrthoDB" id="47801at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23837">
        <property type="entry name" value="UBCc_UBE2O"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000094">
        <property type="entry name" value="Probable ubiquitin-conjugating enzyme E2 23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057733">
        <property type="entry name" value="UBE2O-like_SH3-B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057735">
        <property type="entry name" value="UBE2O-like_tSH3-B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46116">
        <property type="entry name" value="(E3-INDEPENDENT) E2 UBIQUITIN-CONJUGATING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46116:SF15">
        <property type="entry name" value="(E3-INDEPENDENT) E2 UBIQUITIN-CONJUGATING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23043">
        <property type="entry name" value="SH3-B_UBE2O"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23046">
        <property type="entry name" value="tSH3-B_UBE2O"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="4">
        <location>
            <begin position="709"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="554"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="600"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="565"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="600"/>
            <end position="620"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAG11624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="955" mass="106751" checksum="7DA0841078FB1BD5" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CVQ9</accession>
    <name>A0A177CVQ9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CC84DRAFT_1084542</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041242.1">
        <property type="nucleotide sequence ID" value="XM_018174058.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CVQ9"/>
    <dbReference type="STRING" id="1460663.A0A177CVQ9"/>
    <dbReference type="GeneID" id="28757544"/>
    <dbReference type="InParanoid" id="A0A177CVQ9"/>
    <dbReference type="OrthoDB" id="7130006at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004301">
        <property type="term" value="F:epoxide hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097176">
        <property type="term" value="P:epoxide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010497">
        <property type="entry name" value="Epoxide_hydro_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016292">
        <property type="entry name" value="Epoxide_hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21661:SF35">
        <property type="entry name" value="EPOXIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21661">
        <property type="entry name" value="EPOXIDE HYDROLASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06441">
        <property type="entry name" value="EHN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001112">
        <property type="entry name" value="Epoxide_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0058">Aromatic hydrocarbons catabolism</keyword>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epoxide hydrolase N-terminal" evidence="5">
        <location>
            <begin position="4"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="180"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="315"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR001112-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF06441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAG10877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="406" mass="45724" checksum="30CDBB7B6419E54F" modified="2016-09-07" version="1">MTDIHPFTLSIPDARLQHLQEKLALATFPDELEDAGWEHGAPLADIKRLVHHWRTTYDWRRHEASINALPNYETPIDVDGFGHIDIHFVHQVSPNANAIPVLFVHGWPGHFLEVAKLLPLFRDSEKNGGPAFHVVAPSLTNFGFSGVVKKKGFGMKQYAETCHKLMIKLGYEQYVSQGGDWGTFITRTMAMLYPEALKATHINMVACPPPYKNPLALLTLGFKYLTGTFSADEKAGFERTQWFQDHGFGYFKIQSTKPQTVGYALNDSPVALLAWIYEKLHDWTDSYPWTDDEILDWISVYWWSRAGPAASVRIYYEALKGEYTTERTYKTWIPNVKLGLGYFPKELALLPKSWAQSLGPIAFASEHKSGGHFAAFENPEGIVGDMRLMFGKGGGASGVVENKHGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CW20</accession>
    <name>A0A177CW20_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Spliceosomal protein DIB1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_1254146</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Essential role in pre-mRNA splicing. Also essential for entry into mitosis (G2/M progression) as well as for chromosome segregation during mitosis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the DIM1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG11745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042110.1">
        <property type="nucleotide sequence ID" value="XM_018184438.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CW20"/>
    <dbReference type="FunCoup" id="A0A177CW20">
        <property type="interactions" value="892"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CW20"/>
    <dbReference type="GeneID" id="28767924"/>
    <dbReference type="InParanoid" id="A0A177CW20"/>
    <dbReference type="OrthoDB" id="147752at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02954">
        <property type="entry name" value="DIM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000004">
        <property type="entry name" value="Spliceosomal protein DIB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004123">
        <property type="entry name" value="Dim1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12052:SF5">
        <property type="entry name" value="THIOREDOXIN-LIKE PROTEIN 4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12052">
        <property type="entry name" value="THIOREDOXIN-LIKE PROTEN 4A, 4B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02966">
        <property type="entry name" value="DIM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017199">
        <property type="entry name" value="mRNA_splic_U5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01410">
        <property type="entry name" value="DIM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4 6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="39"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR017199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR017199-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAG11745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="143" mass="16840" checksum="AC96126032AFE2FB" modified="2016-09-07" version="1">MGSVVLPHLRTGWHVDQAILSEEDRLVVIRFGRDHDQDCMRQDEVLYKVADKVKNFAVIYLCDLDEVPDFKAMYELYDACTVMFFFRNKHMMCDFGTGNNNKLNWVLEDKQELIDIIETIYRGAKKGRGLVVSPKDYSTRYRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CWW6</accession>
    <name>A0A177CWW6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1210890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG11219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041584.1">
        <property type="nucleotide sequence ID" value="XM_018182331.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CWW6"/>
    <dbReference type="STRING" id="1460663.A0A177CWW6"/>
    <dbReference type="GeneID" id="28765817"/>
    <dbReference type="InParanoid" id="A0A177CWW6"/>
    <dbReference type="OrthoDB" id="4582561at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="184"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="231"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="262"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="319"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="354"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="395"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG11219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="464" mass="52384" checksum="823E3E9BACDEE959" modified="2016-09-07" version="1">MADQKNRTWIPEDSKALRYSNCTSPSAWLVEFIGSMDLLSLRTVDAIFEGYDYYWRENNITKPKIDEVLNWVLNVDECDGQSMCGSHPVSQIIDYAFDHCQADVCRGLPWQGNADQAGRGMIFAYGSQAVLVTIYLIILFISRISKLDSTTDARSTTKTGQTRTLLRRIHDSARETLRTFLDASLLFSIAMIIAAIVTANIALASVRKLETEHLSTGIITRELPLNSTVQLSAFAALLSIFPAIALHSSASSLLRRKVYRQSVWILVGVLVVLMFVLSRMAGSEIFTFHDKNDEDMTFNGKALFENLCIDNQVPSHLRLIVLVFFISLSAFGSIYILSMIPWIQKHLEKIQDALSSMMALFATIAMWIAFGAFYYYRKQVEKNAGETNENHKWTFGQVIGLCTFAPIVVEFLFVLVERPEKALTGTMSKRFQVNSVKHSIEEEQTYTEIGFSDEVPLRVVERAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CX92</accession>
    <name>A0A177CX92_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zinc transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CC84DRAFT_1107017</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Functions as a zinc transporter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Endoplasmic reticulum membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG11480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041845.1">
        <property type="nucleotide sequence ID" value="XM_018175161.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CX92"/>
    <dbReference type="STRING" id="1460663.A0A177CX92"/>
    <dbReference type="GeneID" id="28758647"/>
    <dbReference type="InParanoid" id="A0A177CX92"/>
    <dbReference type="OrthoDB" id="78669at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006882">
        <property type="term" value="P:intracellular zinc ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904257">
        <property type="term" value="P:zinc ion import into Golgi lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1510.10:FF:000014">
        <property type="entry name" value="Cation efflux protein/ zinc transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045316">
        <property type="entry name" value="Msc2-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45755">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45755:SF4">
        <property type="entry name" value="ZINC TRANSPORTER 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="273"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="334"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="395"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="420"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="474"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="557"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="627"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="661"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="713"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="744"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="11">
        <location>
            <begin position="559"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="496"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="814"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="34"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="814"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="835"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="854"/>
            <end position="875"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU369017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OAG11480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="935" mass="101225" checksum="F26759780F432F3A" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CXC7</accession>
    <name>A0A177CXC7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CC84DRAFT_71838</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042548.1">
        <property type="nucleotide sequence ID" value="XM_018187148.1"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CXC7"/>
    <dbReference type="GeneID" id="28770634"/>
    <dbReference type="InParanoid" id="A0A177CXC7"/>
    <dbReference type="OrthoDB" id="1893551at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051625">
        <property type="entry name" value="Signaling_Regulatory_Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22872">
        <property type="entry name" value="BTK-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22872:SF2">
        <property type="entry name" value="INHIBITOR OF BRUTON TYROSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="125"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="336"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="390"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="5">
        <location>
            <begin position="916"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="198"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1162"/>
            <end position="1194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1310"/>
            <end position="1479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1526"/>
            <end position="1639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="198"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1310"/>
            <end position="1319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="1351"/>
            <end position="1364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="1382"/>
            <end position="1391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1422"/>
            <end position="1437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1451"/>
            <end position="1462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1526"/>
            <end position="1540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1547"/>
            <end position="1556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1557"/>
            <end position="1577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="1605"/>
            <end position="1621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1630"/>
            <end position="1639"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAG12183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="1639" mass="180559" checksum="65E1FC8FEDEF4926" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CXI1</accession>
    <name>A0A177CXI1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Neutral ceramidase</fullName>
            <ecNumber evidence="4">3.5.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_1211196</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>an N-acylsphing-4-enine + H2O = sphing-4-enine + a fatty acid</text>
            <dbReference type="Rhea" id="RHEA:20856"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:52639"/>
            <dbReference type="ChEBI" id="CHEBI:57756"/>
            <dbReference type="EC" id="3.5.1.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="3">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the neutral ceramidase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.23" evidence="4"/>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG11537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041902.1">
        <property type="nucleotide sequence ID" value="XM_018182355.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CXI1"/>
    <dbReference type="STRING" id="1460663.A0A177CXI1"/>
    <dbReference type="GeneID" id="28765841"/>
    <dbReference type="InParanoid" id="A0A177CXI1"/>
    <dbReference type="OrthoDB" id="191371at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017040">
        <property type="term" value="F:N-acylsphingosine amidohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046514">
        <property type="term" value="P:ceramide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042759">
        <property type="term" value="P:long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046512">
        <property type="term" value="P:sphingosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.2300:FF:000004">
        <property type="entry name" value="Neutral/alkaline nonlysosomal ceramidase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2300">
        <property type="entry name" value="Neutral/alkaline non-lysosomal ceramidase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006823">
        <property type="entry name" value="Ceramidase_alk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038445">
        <property type="entry name" value="NCDase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031331">
        <property type="entry name" value="NEUT/ALK_ceramidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031329">
        <property type="entry name" value="NEUT/ALK_ceramidase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12670">
        <property type="entry name" value="CERAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12670:SF1">
        <property type="entry name" value="NEUTRAL CERAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04734">
        <property type="entry name" value="Ceramidase_alk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17048">
        <property type="entry name" value="Ceramidse_alk_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008058717" description="Neutral ceramidase" evidence="5">
        <location>
            <begin position="29"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="domain" description="Neutral/alkaline non-lysosomal ceramidase N-terminal" evidence="6">
        <location>
            <begin position="67"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="domain" description="Neutral/alkaline non-lysosomal ceramidase C-terminal" evidence="7">
        <location>
            <begin position="593"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="272"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="517"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="560"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR606823-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU366019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAG11537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="756" mass="80231" checksum="967954B6DF406598" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CXI5</accession>
    <name>A0A177CXI5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GTPase binding protein Rid1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_92090</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042608.1">
        <property type="nucleotide sequence ID" value="XM_018187896.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CXI5"/>
    <dbReference type="GeneID" id="28771382"/>
    <dbReference type="InParanoid" id="A0A177CXI5"/>
    <dbReference type="OrthoDB" id="2155261at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010473">
        <property type="entry name" value="GTPase-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06371">
        <property type="entry name" value="Drf_GBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01140">
        <property type="entry name" value="Drf_GBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Formin GTPase-binding" evidence="2">
        <location>
            <begin position="357"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="397"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="821"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="252"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="263"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="303"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="406"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="469"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="482"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG12243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="883" mass="97569" checksum="052882B6B232AA00" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CY48</accession>
    <name>A0A177CY48_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Phox-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_64143</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Essential for proper morphogenesis of the vacuole. May exist as structural reinforcement on the surface of the vacuolar membrane and be required for maintenance against rupture by osmotic pressure.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG11978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042343.1">
        <property type="nucleotide sequence ID" value="XM_018186985.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CY48"/>
    <dbReference type="FunCoup" id="A0A177CY48">
        <property type="interactions" value="127"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CY48"/>
    <dbReference type="GeneID" id="28770471"/>
    <dbReference type="InParanoid" id="A0A177CY48"/>
    <dbReference type="OrthoDB" id="428895at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097576">
        <property type="term" value="P:vacuole fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06897">
        <property type="entry name" value="PX_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15858">
        <property type="entry name" value="SNARE_VAM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000058">
        <property type="entry name" value="VAM7p Vacuolar SNARE protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0926">Vacuole</keyword>
    <feature type="domain" description="PX" evidence="7">
        <location>
            <begin position="2"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="6">
        <location>
            <begin position="313"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="276"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00054927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAG11978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="376" mass="41229" checksum="E835290B4B9A7622" modified="2016-09-07" version="1">MAPLRLSIPTTHTESDGGKEFTTYEIRIEHPFPRASTSLRKRYSDFAALDSTLRSHVGPPPASLPPKSWLGGFLGLGSTLGSPEQIEKRRQALEQYLQAIETSEDGRWRVTPAYREFLDLGSDKDKKTANLPGAQFGKDRVRDSTDWLDKYQEVKSNLQDARRWLTSREQATAATAQHEAGANAKKGLVRAGTLLSALEEGLTRLGGGGDGWGGDKLGDGEIRRRRDLIGTSRKERDGLESVLNTLAVKAAASGSTSSAPSTNSAAATNEQKAGLFSRANQGAGRSGRVLGGPAKETERTRELDNDGVLQLQEQIIAEQDQDLVDLTTVVRRMKEMGVQINDELQYQNELLNQFGDDVERVDGKMKIAKKRIAKIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CY57</accession>
    <name>A0A177CY57_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glutathione S-transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CC84DRAFT_1201104</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the GST superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG11988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042353.1">
        <property type="nucleotide sequence ID" value="XM_018181703.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CY57"/>
    <dbReference type="FunCoup" id="A0A177CY57">
        <property type="interactions" value="690"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CY57"/>
    <dbReference type="GeneID" id="28765189"/>
    <dbReference type="InParanoid" id="A0A177CY57"/>
    <dbReference type="OrthoDB" id="422574at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd10291">
        <property type="entry name" value="GST_C_YfcG_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03048">
        <property type="entry name" value="GST_N_Ure2p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051:SF8">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE GSTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00043">
        <property type="entry name" value="GST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01151">
        <property type="entry name" value="Main.2:_Nu-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST N-terminal" evidence="3">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="4">
        <location>
            <begin position="93"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAG11988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="250" mass="28807" checksum="7FF16734D4AC3AD3" modified="2016-09-07" version="1">MGITLYTEGTPNGLKASIALEELGLEYKVVTLDFNLHEQKEPWFLEINPNGRIPALTDKGEGGRETTIFESGAILLYLVATYDKDNKISYPYGTKEHWETINWLMWQMGGLGPMQGQANHFTRFAPEKLKYPIDRYVNETHRLYRILDRQLAKNGTGYVVGDRVTVADIAVWPWIAAHNFSGITSIAQYTEIVKWFENLLQRPGFEAGRNVPRPHFHITLNELPEEELDKIAEHGKKWQDEARERETFVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CY72</accession>
    <name>A0A177CY72_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_124682</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042880.1">
        <property type="nucleotide sequence ID" value="XM_018184212.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CY72"/>
    <dbReference type="GeneID" id="28767698"/>
    <dbReference type="InParanoid" id="A0A177CY72"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="13"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG12515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="168" mass="19114" checksum="6FD946B2844BAF5F" modified="2016-09-07" version="1">MATPYPRTQIIQRQRVSQSMLDPEYNPTRQSASTLSPRHAEGFEHGANLPVRLLPNSDPGRSSNTMKDGPGHFKGPRGSDRINTSIGHFTIHASMRRVQWSSFVTGRDDCLNRQVCERTHNLSAIQQDVDSCNVRLVYEALASQGERHNCSTRWHCKFSTIRVRREAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CYW2</accession>
    <name>A0A177CYW2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1135154</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042841.1">
        <property type="nucleotide sequence ID" value="XM_018176048.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CYW2"/>
    <dbReference type="STRING" id="1460663.A0A177CYW2"/>
    <dbReference type="GeneID" id="28759534"/>
    <dbReference type="InParanoid" id="A0A177CYW2"/>
    <dbReference type="OrthoDB" id="5408302at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="266"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="488"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="774"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="975"/>
            <end position="1083"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="335"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="362"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="429"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="791"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="975"/>
            <end position="995"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1046"/>
            <end position="1059"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1067"/>
            <end position="1081"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG12476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="1152" mass="124094" checksum="C13F394850ED7C77" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2023-06-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CZ53</accession>
    <name>A0A177CZ53_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_127041</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042921.1">
        <property type="nucleotide sequence ID" value="XM_018185354.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CZ53"/>
    <dbReference type="GeneID" id="28768840"/>
    <dbReference type="InParanoid" id="A0A177CZ53"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG12556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="150" mass="16143" checksum="D64BBD009294BD27" modified="2016-09-07" version="1">MYHSRADSVESTALDGTSTAEVYVGKSTACAEVGCLHLHLQRDNCLHHSWAERQNRNGSNSYASKPSAAHAEPHATLFALDARPIGDVPKGLRALPRIRCVPCDVRPTLRVVTGPSTIVCIGQLARVPSASEPHICNGYPLWGLTWCASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CZ58</accession>
    <name>A0A177CZ58_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Carboxypeptidase s</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CC84DRAFT_1159688</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M20A family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042723.1">
        <property type="nucleotide sequence ID" value="XM_018177298.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CZ58"/>
    <dbReference type="FunCoup" id="A0A177CZ58">
        <property type="interactions" value="30"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CZ58"/>
    <dbReference type="GeneID" id="28760784"/>
    <dbReference type="InParanoid" id="A0A177CZ58"/>
    <dbReference type="OrthoDB" id="3064516at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000328">
        <property type="term" value="C:fungal-type vacuole lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05674">
        <property type="entry name" value="M20_yscS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000027">
        <property type="entry name" value="N-fatty-acyl-amino acid synthase/hydrolase PM20D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001261">
        <property type="entry name" value="ArgE/DapE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017141">
        <property type="entry name" value="Pept_M20_carboxypep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047177">
        <property type="entry name" value="Pept_M20A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45962">
        <property type="entry name" value="N-FATTY-ACYL-AMINO ACID SYNTHASE/HYDROLASE PM20D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45962:SF1">
        <property type="entry name" value="N-FATTY-ACYL-AMINO ACID SYNTHASE_HYDROLASE PM20D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037217">
        <property type="entry name" value="Carboxypeptidase_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="Bacterial exopeptidase dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00759">
        <property type="entry name" value="ARGE_DAPE_CPG2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M20 dimerisation" evidence="8">
        <location>
            <begin position="287"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="173"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="240"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="241"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="269"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="544"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR037217-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR037217-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAG12358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="574" mass="62842" checksum="6638C2AD722138FF" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CZH6</accession>
    <name>A0A177CZH6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1159592</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042615.1">
        <property type="nucleotide sequence ID" value="XM_018177278.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CZH6"/>
    <dbReference type="STRING" id="1460663.A0A177CZH6"/>
    <dbReference type="GeneID" id="28760764"/>
    <dbReference type="InParanoid" id="A0A177CZH6"/>
    <dbReference type="OrthoDB" id="5343576at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="383"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="461"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="383"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="465"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG12250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="523" mass="57107" checksum="ADAAE812297E5C5C" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CZM9</accession>
    <name>A0A177CZM9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1160204</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018043328.1">
        <property type="nucleotide sequence ID" value="XM_018177437.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CZM9"/>
    <dbReference type="STRING" id="1460663.A0A177CZM9"/>
    <dbReference type="GeneID" id="28760923"/>
    <dbReference type="InParanoid" id="A0A177CZM9"/>
    <dbReference type="OrthoDB" id="10013825at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.10.10">
        <property type="entry name" value="Trypsin Inhibitor V, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021719">
        <property type="entry name" value="Prot_inh_I78"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39600">
        <property type="entry name" value="PEPTIDASE INHIBITOR I78 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39600:SF1">
        <property type="entry name" value="PEPTIDASE INHIBITOR I78 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11720">
        <property type="entry name" value="Inhibitor_I78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG12963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="57" mass="6516" checksum="56BC247C91751520" modified="2016-09-07" version="1">MGKKIGDNHDEVTFAKKDLPSEHRVLQPDSMSTMDHKPDRLNIHVDEQGTVKNVRYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CZQ3</accession>
    <name>A0A177CZQ3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1211948</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042747.1">
        <property type="nucleotide sequence ID" value="XM_018182413.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CZQ3"/>
    <dbReference type="GeneID" id="28765899"/>
    <dbReference type="InParanoid" id="A0A177CZQ3"/>
    <dbReference type="OrthoDB" id="3775757at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="200"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="271"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="271"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG12382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="312" mass="34943" checksum="9A6B37AA44B7B008" modified="2016-09-07" version="1">MTTPAANSHARKRAMPPTSPSGKPVPSSPALLAQANPVPGSPTSELQTPRERRSISNRFWEKNGSRAKDGTSGVDLASDSSDPDDDSEAARIKKHDHLHTKVKRLLALETTGAIRLKTLESNKTVREYNKLLDAFAHKPKTKRKRAQCTETLRLFLEDHDQIIDLYNQYAILDHGLHKDRILPEFMRDDDRSASAKKIEQAQASNVRRAPAKHALNKEDDSDEEGVVLQTVKSGEGFDEPSVFNTRGLTVPSIFNRKTSATVEKDQRRFLLHRRDGPLTRDAEGDQHVLDERTAGDQEETPTRPPTKKRRLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177D087</accession>
    <name>A0A177D087_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1160187</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018043311.1">
        <property type="nucleotide sequence ID" value="XM_018177430.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177D087"/>
    <dbReference type="GeneID" id="28760916"/>
    <dbReference type="InParanoid" id="A0A177D087"/>
    <dbReference type="OrthoDB" id="4588567at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="30"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG12946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="123" mass="13557" checksum="0D0AF2F026DAFCA2" modified="2016-09-07" version="1">MANTRTNRFSFGSPVRTPSTSLRRLRTAFSPTRSSRSISPSSTGTTSPLARGRTGSPDSHRSSGSIESIRNLLMLRRKPSVLDLEMEEEKHLFEHELEVLEPRPSLGEAGATVGIFEVLDGKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177D0A4</accession>
    <name>A0A177D0A4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1212127</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042967.1">
        <property type="nucleotide sequence ID" value="XM_018182421.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177D0A4"/>
    <dbReference type="GeneID" id="28765907"/>
    <dbReference type="InParanoid" id="A0A177D0A4"/>
    <dbReference type="OrthoDB" id="3559694at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024316">
        <property type="entry name" value="APQ12"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12716">
        <property type="entry name" value="Apq12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG12602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="159" mass="17981" checksum="0B2854D55F666B10" modified="2016-09-07" version="1">MDVVQNYLALLHTLLPSSLINPLISAISTVYGLTKSLQTHFAPLITQVITQPDIASVLMLLAILWFSLQIFGMLYRSVMFWVRLVWQLAQYSFLIVVSLWIWNRGVDGALRDAQELAGFWMGEYQKFSGEAKAWKVAEEAQIRMQAKQRAAGGGGFGWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177D0B7</accession>
    <name>A0A177D0B7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">WH2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1159899</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042977.1">
        <property type="nucleotide sequence ID" value="XM_018177359.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177D0B7"/>
    <dbReference type="STRING" id="1460663.A0A177D0B7"/>
    <dbReference type="GeneID" id="28760845"/>
    <dbReference type="InParanoid" id="A0A177D0B7"/>
    <dbReference type="OrthoDB" id="2430277at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003124">
        <property type="entry name" value="WH2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02205">
        <property type="entry name" value="WH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00246">
        <property type="entry name" value="WH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51082">
        <property type="entry name" value="WH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WH2" evidence="2">
        <location>
            <begin position="41"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="466"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="225"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="309"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="339"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="376"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="425"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG12612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="494" mass="48830" checksum="1D1BC66D06EB897F" modified="2016-09-07" version="1">MPAPPPPPPPPMPPMGRGAGGPPPPPMPGRAPGGKPPSGAGRGALLGDITKGAKLKKVTVINDRSAPIVGKVSDGPSGPPVGGAPPIPGMGKAPAPPSGLAPPVPGNRARSNSDTGGDGAGGGGGMVSAAPQLGGLFAGGMPKLRKSGGVATGREQSSPYLSDPETSRSSAPRPPRGAAPKPPGAAPPIPGGRPPPAPGIAALRNNLRPSSVVSTHSMSDIGSKPKPPLPGKKPPIPPPSSRKPSGLAPPPPATPARAPPVPGAAPPAPPPPPPSSSPLAPPPPPPPSSTPSAPPPPPPTAAPRAPSRSTPPPPPPAPPSKAPQDDDDEYDPYKYTSTPPKPPSAPAPPAPKAPTNGTPSLAEQAARNAFGRSSPAAPPPPPPSSAPAPPPPPSSAPAPPPPPMSPPSRTNSQAPQRSMLDPSAYTLTNGGSPSIKSPTSPAPGQKGKIVPVHDLRWRFVDESQFPRPREFLGGPKKYRAGRGSSVPLDLSAFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177D1S3</accession>
    <name>A0A177D1S3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Rcd1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1183585</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CNOT9 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG13132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018043497.1">
        <property type="nucleotide sequence ID" value="XM_018180695.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177D1S3"/>
    <dbReference type="FunCoup" id="A0A177D1S3">
        <property type="interactions" value="862"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177D1S3"/>
    <dbReference type="GeneID" id="28764181"/>
    <dbReference type="InParanoid" id="A0A177D1S3"/>
    <dbReference type="OrthoDB" id="1183224at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030014">
        <property type="term" value="C:CCR4-NOT complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006402">
        <property type="term" value="P:mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000014">
        <property type="entry name" value="Cell differentiation protein RCD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007216">
        <property type="entry name" value="CNOT9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12262">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04078">
        <property type="entry name" value="Rcd1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="19"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="29"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG13132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="373" mass="41324" checksum="4B86253C0387BA14" modified="2016-09-07" version="1">MQHVYPHQQQYPGEWSQHHQQHPTHHVAHQQQGQLQAHQAQAQAAAVAAAAAQQQHFARMAGNNGNSVPGGGIIPRGPANDVQGNSQAVMSEENQRVLEWIAQLMKPNTRETALLELSKKREQVPELALILWHSFGVMASLLQEIISVYPLLNPSQLTAAASNRVCNALALLQCVASHTETRGLFLGAHIPLFLYPFLNTTSKSRPFEYLRLTSLGVIGALVKNDSSEVINFLLTTEIIPLCLRIMETGSELSKTVAIFIVQKILLDDTGLAYICQTYERFYAVGTVLSNMVNQLVEQQTVRLLKHVVRCFLRLSDNARAREALRQCLPEPLRDATFSSVLRDDAATKRCLAQLLINLSDNVAEVGGNQLNLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BTV7</accession>
    <name>A0A177BTV7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1223580</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441564">
        <property type="protein sequence ID" value="OAF98843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029209.1">
        <property type="nucleotide sequence ID" value="XM_018183506.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BTV7"/>
    <dbReference type="GeneID" id="28766992"/>
    <dbReference type="InParanoid" id="A0A177BTV7"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008057401" evidence="2">
        <location>
            <begin position="22"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="51"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAF98843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="94" mass="9287" checksum="65B746E06A9AD586" modified="2016-09-07" version="1">MFRSIILTLGLVAVLVAGHEGHDDGHSAVVYTTVMVMDGMTTTMEMTATASEHSSATAAAGSSTSASGLAHPTSVPTQIGVAGIFVAALAGIGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2023-06-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BVV8</accession>
    <name>A0A177BVV8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1181389</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441562">
        <property type="protein sequence ID" value="OAF99245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029611.1">
        <property type="nucleotide sequence ID" value="XM_018180556.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BVV8"/>
    <dbReference type="GeneID" id="28764042"/>
    <dbReference type="InParanoid" id="A0A177BVV8"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAF99245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="220" mass="24568" checksum="46EA37013FACA2EA" modified="2016-09-07" version="1">MSEVPSSTTPEWFSNEWKLGRRFAQKCFEMVDEYSEKGVGDANPDRVGFPKIVLDPNSQDRICEELFEADGNTVPGTMGMKQTFDLLCQVFLKNENTEKVIIWGTDEDSLKESGLSQHELDGLSQDNWQTLVTTAGQLIVAEGLKDGKYGVSDPTYKHFEVEKSLTLKVGFSGSSEKELLAIFTLDIPAEYSDAYLANNTSDVDEVFFLGISNIPEPRDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BW17</accession>
    <name>A0A177BW17_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">IF4E-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1104541</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic initiation factor 4E family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441562">
        <property type="protein sequence ID" value="OAF99494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029860.1">
        <property type="nucleotide sequence ID" value="XM_018175063.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BW17"/>
    <dbReference type="STRING" id="1460663.A0A177BW17"/>
    <dbReference type="GeneID" id="28758549"/>
    <dbReference type="InParanoid" id="A0A177BW17"/>
    <dbReference type="OrthoDB" id="590761at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016281">
        <property type="term" value="C:eukaryotic translation initiation factor 4F complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000340">
        <property type="term" value="F:RNA 7-methylguanosine cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.760.10:FF:000015">
        <property type="entry name" value="Translation initiation factor eIF4E3, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.760.10">
        <property type="entry name" value="RNA Cap, Translation Initiation Factor Eif4e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023398">
        <property type="entry name" value="TIF_eIF4e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001040">
        <property type="entry name" value="TIF_eIF_4E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019770">
        <property type="entry name" value="TIF_eIF_4E_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11960:SF18">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E HOMOLOGOUS PROTEIN, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11960">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01652">
        <property type="entry name" value="IF4E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55418">
        <property type="entry name" value="eIF4e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00813">
        <property type="entry name" value="IF4E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="1" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="107"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="320"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="12"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="33"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="339"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAF99494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="348" mass="38467" checksum="86A097554C3C226F" modified="2016-09-07" version="1">MDSRDNLWTRRSNSSKLSLSMNSGDGKPDPPQRTFSATKRFGDTSSHGGRNPFNALSPITAGGLASPTTSGQTAFGLGSGAFASFGSANKTPKTPGTAFDFKAATMGGGAPVTPSEKKDKPAGKAVNSARKESLSTTASEEAPVSSAPLDFNVPWPLKYTWVIWYRPPTPKNSDYEKSTKALCRMSSVQEFWKVFVHLKRPSTLPTVSDYHFFKEGIRPVWEDDENKRGGKWIMRLKKGVADRYWEELLMAMTGGEFMEATEEVCGFVLSVRSGEDVFSIWTKNDGGRNIKIRETVKRVLNLPEGTIITWRSHDESIAQRTAIDQARQDKGHQEKRRPNTSTTEESSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BWB7</accession>
    <name>A0A177BWB7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_383019</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441561">
        <property type="protein sequence ID" value="OAF99783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030149.1">
        <property type="nucleotide sequence ID" value="XM_018185986.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BWB7"/>
    <dbReference type="STRING" id="1460663.A0A177BWB7"/>
    <dbReference type="GeneID" id="28769472"/>
    <dbReference type="InParanoid" id="A0A177BWB7"/>
    <dbReference type="OrthoDB" id="3782588at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAF99783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="327" mass="37703" checksum="6070B604670440B9" modified="2016-09-07" version="1">MVKIIRYYSSTLEWTKLPQSKNEPVMSGRIHDVDMEGIEAAMEDKLVLRQGLRRKRSRADSSGFVDIEETAAKRVKVPELKRVQPEQFPAFTGTITIHVKNKGRKRKPLSLHIERDRVSSGFIARSVSNSFSDWIATVPKPIDLTHEDPLLVKHYVKWANTRTIGTRKKQRLVSLQEKSRPDYKESLTLDTEQLALCYGLGERLEDAAYRNALLFTMRYYLVKEEAFPSDRTVAIIYEQTKRRSPARKLMVDFWAYAGNISWLEGRDVEFSVCLDFFEDLFPALLRARAKPEKATWPWADNADAYLVAGGEAQTEEGIMFKEKSMEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BWG1</accession>
    <name>A0A177BWG1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1210093</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441561">
        <property type="protein sequence ID" value="OAF99823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030189.1">
        <property type="nucleotide sequence ID" value="XM_018182264.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BWG1"/>
    <dbReference type="GeneID" id="28765750"/>
    <dbReference type="InParanoid" id="A0A177BWG1"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAF99823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="121" mass="13672" checksum="6067C67AD074E173" modified="2016-09-07" version="1">MGISNNLLYAFRMAKSHTLEIRWKKTKDLLSRLATQLLRVRLTTRTKVTISAKNKENPAGNDAAGDEADGYNNGPGVSSAHRKKQGPTSRDEVPHIDEVPGTTVSWRDYDDKEGWEEWYIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BWL2</accession>
    <name>A0A177BWL2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1051184</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441563">
        <property type="protein sequence ID" value="OAF99141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029507.1">
        <property type="nucleotide sequence ID" value="XM_018173480.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BWL2"/>
    <dbReference type="GeneID" id="28756966"/>
    <dbReference type="InParanoid" id="A0A177BWL2"/>
    <dbReference type="OrthoDB" id="3938057at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAF99141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="85" mass="8821" checksum="2C46F088255F560F" modified="2016-09-07" version="1" fragment="single">AANDANSGGGGGKVVSEDTVAVLLMAMGSTSISKAQYNIMSSLDGTRTASSFEHSFRSIIKKAKELQARVDAGETFEAVAPAKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BWP4</accession>
    <name>A0A177BWP4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CobW domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1105642</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441564">
        <property type="protein sequence ID" value="OAF98739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029105.1">
        <property type="nucleotide sequence ID" value="XM_018175105.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BWP4"/>
    <dbReference type="STRING" id="1460663.A0A177BWP4"/>
    <dbReference type="GeneID" id="28758591"/>
    <dbReference type="InParanoid" id="A0A177BWP4"/>
    <dbReference type="OrthoDB" id="259708at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03112">
        <property type="entry name" value="CobW-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1220.10">
        <property type="entry name" value="CobW-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036627">
        <property type="entry name" value="CobW-likC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003495">
        <property type="entry name" value="CobW/HypB/UreG_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051316">
        <property type="entry name" value="Zinc-reg_GTPase_activator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13748:SF62">
        <property type="entry name" value="COBW DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13748">
        <property type="entry name" value="COBW-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02492">
        <property type="entry name" value="cobW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CobW/HypB/UreG nucleotide-binding" evidence="1">
        <location>
            <begin position="7"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAF98739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="366" mass="39545" checksum="ACB03F4AE17249FB" modified="2016-09-07" version="1">MAPIPIPITIITGFLGSGKTTLILNLIPQLPKTYKLALLKNEFGDVAVDSELASSSAISGVQELLNGCICCNLVGQLSDALATLAADIAPDRIVIETSGSAFPATLAMEVNRLAHSTAKYVLDGVMSVIDVENWKGYEDTSYTAKMQAKYTDVVVLNKWELVGERRLEDVEDAVLALEVDPPIPRTKSDRGWVSKDIVFGLDPKLVKAAGSKSEYHHDHDHSSEVEVLSVALTSNGNNASVDLGKLEKLLREPTKDSVYRIKGVLYASSAPTSSQSDSQSTLSVAGDRTRYILNWAFGRWTFTPVPPLSANNTALASGTTIEEPELRLTVITAKYESNQFQKVIESSGFIALDGNSEGKLTIERVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BXZ9</accession>
    <name>A0A177BXZ9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Dickkopf N-terminal cysteine-rich domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1180836</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441560">
        <property type="protein sequence ID" value="OAG00006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030371.1">
        <property type="nucleotide sequence ID" value="XM_018180511.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BXZ9"/>
    <dbReference type="GeneID" id="28763997"/>
    <dbReference type="InParanoid" id="A0A177BXZ9"/>
    <dbReference type="OrthoDB" id="5413589at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008057476" description="Dickkopf N-terminal cysteine-rich domain-containing protein" evidence="2">
        <location>
            <begin position="18"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG00006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="278" mass="27773" checksum="91DE52BC66B7F298" modified="2016-09-07" version="1">MQYHFLTVVAAAAYVSAQATESLVPVGGNCDPKGTACAEGANCYAVNSMLQTVCGNFQASCTKDAQCAFNTCNLQQGLCNGFLPSSASSSATAPPATSSSACPAPGSTDNQGRYSCNPAHQYPSGQQCVVIDGCYFLSSTVPSTATSAPTSLPTAAAGTLPLGAQCDPRATPSPCAGGAQCWASNSMLIAACGNFNAACKQDSECAFNTCNNGLCNGFKPTGINNGTSTAQSTGGHGATSAPTSTYTPPAFTGAATLSRTIETSGLMAALLAAAAWIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BY59</accession>
    <name>A0A177BY59_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Methylthioribose-1-phosphate isomerase</fullName>
            <shortName evidence="4">M1Pi</shortName>
            <shortName evidence="4">MTR-1-P isomerase</shortName>
            <ecNumber evidence="4">5.3.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">S-methyl-5-thioribose-1-phosphate isomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Translation initiation factor eIF-2B subunit alpha/beta/delta-like protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">MRI1</name>
        <name evidence="5" type="ORF">CC84DRAFT_1190415</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>5-(methylsulfanyl)-alpha-D-ribose 1-phosphate = 5-(methylsulfanyl)-D-ribulose 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:19989"/>
            <dbReference type="ChEBI" id="CHEBI:58533"/>
            <dbReference type="ChEBI" id="CHEBI:58548"/>
            <dbReference type="EC" id="5.3.1.23"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 1/6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.23" evidence="4"/>
    <dbReference type="EMBL" id="KV441559">
        <property type="protein sequence ID" value="OAG00293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030658.1">
        <property type="nucleotide sequence ID" value="XM_018181114.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BY59"/>
    <dbReference type="FunCoup" id="A0A177BY59">
        <property type="interactions" value="722"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177BY59"/>
    <dbReference type="GeneID" id="28764600"/>
    <dbReference type="InParanoid" id="A0A177BY59"/>
    <dbReference type="OrthoDB" id="2461at2759"/>
    <dbReference type="UniPathway" id="UPA00904">
        <property type="reaction ID" value="UER00874"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046523">
        <property type="term" value="F:S-methyl-5-thioribose-1-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019509">
        <property type="term" value="P:L-methionine salvage from methylthioadenosine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.420:FF:000003">
        <property type="entry name" value="Methylthioribose-1-phosphate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10470:FF:000010">
        <property type="entry name" value="Methylthioribose-1-phosphate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.420">
        <property type="entry name" value="translation initiation factor eif-2b, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10470">
        <property type="entry name" value="Translation initiation factor eif-2b, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01678">
        <property type="entry name" value="Salvage_MtnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000649">
        <property type="entry name" value="IF-2B-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005251">
        <property type="entry name" value="IF-M1Pi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042529">
        <property type="entry name" value="IF_2B-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011559">
        <property type="entry name" value="Initiation_fac_2B_a/b/d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027363">
        <property type="entry name" value="M1Pi_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00524">
        <property type="entry name" value="eIF-2B_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004326">
        <property type="entry name" value="PRK05720.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00512">
        <property type="entry name" value="salvage_mtnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43475">
        <property type="entry name" value="METHYLTHIORIBOSE-1-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43475:SF1">
        <property type="entry name" value="METHYLTHIORIBOSE-1-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01008">
        <property type="entry name" value="IF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 4 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2 4" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="253"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="4">
        <location>
            <position position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAG00293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="392" mass="41805" checksum="C7A073A96ACCF640" modified="2016-09-07" version="1">MVLQAIKYSRGQLEILDQLKLPHAEEYDHIYSSTDAWHAIKEMRTRGAPAIAIVAALALAVELTNMKLPSIAEEVKVFIIEKLDYLVTSRPTAVNLADAARKLKKATEESATREGATGDSVREAYVSASEQMLIDDVSDNENIGRHGADWIVKHTIAAKKGPVSMLTHCNTGSLATAGYGTALGVIRSLHAQGNLKHAFCSETRPYNQGSRLTAFELVHDKIPATLVTDSMAAALLRLRGPSENIAGIVVGADRVAANGDTANKIGTYSLAILAKHHGVKFLVAAPRTTIDLDTKSGADIVIEERPGKEVTLVKGPRHDGVNLDLGVVETVSIAANGIGVWNPAFDVTPAELIDGIITEVGVVEKDSKGVFHLDKVFEVAGSTIKPSSVGEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BZ61</accession>
    <name>A0A177BZ61_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Lethal giant larvae (Lgl)-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CC84DRAFT_380430</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat L(2)GL family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441561">
        <property type="protein sequence ID" value="OAF99726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030092.1">
        <property type="nucleotide sequence ID" value="XM_018185971.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BZ61"/>
    <dbReference type="FunCoup" id="A0A177BZ61">
        <property type="interactions" value="129"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177BZ61"/>
    <dbReference type="GeneID" id="28769457"/>
    <dbReference type="InParanoid" id="A0A177BZ61"/>
    <dbReference type="OrthoDB" id="19944at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045159">
        <property type="term" value="F:myosin II binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15873">
        <property type="entry name" value="R-SNARE_STXBP5_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000848">
        <property type="entry name" value="SNARE-dependent exocytosis protein (Sro7), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013905">
        <property type="entry name" value="Lgl_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10241">
        <property type="entry name" value="LETHAL 2 GIANT LARVAE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10241:SF25">
        <property type="entry name" value="TOMOSYN, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08596">
        <property type="entry name" value="Lgl_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="230"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="459"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="domain" description="Lethal giant larvae (Lgl)-like C-terminal" evidence="5">
        <location>
            <begin position="518"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="895"/>
            <end position="943"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAF99726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="1001" mass="108748" checksum="FF491E6EEB224326" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BZM5</accession>
    <name>A0A177BZM5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">3-chlorobenzoate-3,4-dioxygenase reductase subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CC84DRAFT_355982</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441560">
        <property type="protein sequence ID" value="OAF99997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030363.1">
        <property type="nucleotide sequence ID" value="XM_018185883.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BZM5"/>
    <dbReference type="STRING" id="1460663.A0A177BZM5"/>
    <dbReference type="GeneID" id="28769369"/>
    <dbReference type="InParanoid" id="A0A177BZM5"/>
    <dbReference type="OrthoDB" id="5390at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030151">
        <property type="term" value="F:molybdenum ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06185">
        <property type="entry name" value="PDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.33.20">
        <property type="entry name" value="PK beta-barrel domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052353">
        <property type="entry name" value="Benzoxazolinone_Detox_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005302">
        <property type="entry name" value="MoCF_Sase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011037">
        <property type="entry name" value="Pyrv_Knase-like_insert_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005163">
        <property type="entry name" value="Tri_helical_YiiM-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30212">
        <property type="entry name" value="PROTEIN YIIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30212:SF2">
        <property type="entry name" value="PROTEIN YIIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03473">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03475">
        <property type="entry name" value="YiiM_3-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00409">
        <property type="entry name" value="PHDIOXRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="2Fe-2S ferredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50800">
        <property type="entry name" value="PK beta-barrel domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51340">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="7" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MOSC" evidence="5">
        <location>
            <begin position="54"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="6">
        <location>
            <begin position="258"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="4">
        <location>
            <begin position="480"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAF99997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="564" mass="62246" checksum="B6FF72DC249B4F8E" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C037</accession>
    <name>A0A177C037_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">P-type Cu(+) transporter</fullName>
            <ecNumber evidence="3">7.2.2.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Cu(2+)-ATPase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CC84DRAFT_1168293</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="17">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 17">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.8" evidence="3"/>
    <dbReference type="EMBL" id="KV441558">
        <property type="protein sequence ID" value="OAG01154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031519.1">
        <property type="nucleotide sequence ID" value="XM_018179364.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C037"/>
    <dbReference type="FunCoup" id="A0A177C037">
        <property type="interactions" value="449"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177C037"/>
    <dbReference type="GeneID" id="28762850"/>
    <dbReference type="InParanoid" id="A0A177C037"/>
    <dbReference type="OrthoDB" id="432719at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043682">
        <property type="term" value="F:P-type divalent copper transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140581">
        <property type="term" value="F:P-type monovalent copper transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055070">
        <property type="term" value="P:copper ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030003">
        <property type="term" value="P:intracellular monoatomic cation homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="CDD" id="cd02094">
        <property type="entry name" value="P-type_ATPase_Cu-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.100:FF:000001">
        <property type="entry name" value="ATPase copper transporting beta"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000002">
        <property type="entry name" value="Copper-transporting ATPase 1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006122">
        <property type="entry name" value="HMA_Cu_ion-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027256">
        <property type="entry name" value="P-typ_ATPase_IB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01525">
        <property type="entry name" value="ATPase-IB_hvy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00003">
        <property type="entry name" value="copper ion binding protein"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43520">
        <property type="entry name" value="ATP7, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43520:SF8">
        <property type="entry name" value="P-TYPE CU(+) TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00942">
        <property type="entry name" value="CUATPASEI"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="HMA, heavy metal-associated domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0186">Copper</keyword>
    <keyword evidence="9" id="KW-0187">Copper transport</keyword>
    <keyword evidence="14" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="15 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="12" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="376"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="410"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="451"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="480"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="661"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="703"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1054"/>
            <end position="1077"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1083"/>
            <end position="1105"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="18">
        <location>
            <begin position="16"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="18">
        <location>
            <begin position="112"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="18">
        <location>
            <begin position="201"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="18">
        <location>
            <begin position="284"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00080126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU362081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="OAG01154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="1172" mass="123901" checksum="5C68D4C35934EA20" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C0M6</accession>
    <name>A0A177C0M6_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Beta/gamma crystallin 'Greek key' domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1189713</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441557">
        <property type="protein sequence ID" value="OAG01344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031709.1">
        <property type="nucleotide sequence ID" value="XM_018181071.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C0M6"/>
    <dbReference type="GeneID" id="28764557"/>
    <dbReference type="InParanoid" id="A0A177C0M6"/>
    <dbReference type="OrthoDB" id="3774233at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008057540" description="Beta/gamma crystallin 'Greek key' domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG01344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="130" mass="14116" checksum="9C298C3BC88D6661" modified="2016-09-07" version="1">MKAGIATLGLLAGLLDGVQAQYVATDHIRVFLFGQTSYFSEVAVDVRNNTCLSLDNNLIDGKVQSVLVGGHNIWDVYQRNDEWYCILYDNFDCTGSEASMITVAGGTNNLATAGWGNRVHGLRCINDDPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C129</accession>
    <name>A0A177C129_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1180250</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441558">
        <property type="protein sequence ID" value="OAG01195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031560.1">
        <property type="nucleotide sequence ID" value="XM_018180462.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C129"/>
    <dbReference type="GeneID" id="28763948"/>
    <dbReference type="InParanoid" id="A0A177C129"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008057564" evidence="2">
        <location>
            <begin position="18"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG01195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="179" mass="19603" checksum="61F17B1F77A5E3EE" modified="2016-09-07" version="1">MRFSVIALAALLGTAYALPLVAEGPEDAVLRTPLTLRSAEPEAIPEADPKKHKHHQKGKDGKKKDHAARDASADPEAEAKKHHHKLGKDKHHKDKGTNTARGEKHDGKAAKSADKAAKHNEKAGKHDDKGKKHDGKGGKHEKGEKKGGKNPRDADPKKKHKEHYHKENHKEEKGKGNNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C1C1</accession>
    <name>A0A177C1C1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Serine/threonine-protein kinase crk1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CC84DRAFT_1168737</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV441559">
        <property type="protein sequence ID" value="OAG00679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031044.1">
        <property type="nucleotide sequence ID" value="XM_018179470.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C1C1"/>
    <dbReference type="FunCoup" id="A0A177C1C1">
        <property type="interactions" value="1035"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177C1C1"/>
    <dbReference type="GeneID" id="28762956"/>
    <dbReference type="InParanoid" id="A0A177C1C1"/>
    <dbReference type="OrthoDB" id="1732493at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070985">
        <property type="term" value="C:transcription factor TFIIK complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008353">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000624">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF0">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="68"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="364"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="366"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OAG00679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="412" mass="46039" checksum="118715B18ACDDE5B" modified="2016-09-07" version="1">MGMSPALSPRPNPPGSNAPANAAKARPLVHLLNHKTVPSPSLASTATTPGGPDEGLAEEMNDVVKNQFVFGSRLGEGTYATVYRGHYRDDPSKLVAIKKMKKNAEWQDGINLDSLREMKYLAELHHPHVINLIAVFTTKDENINLVLEHLPRGELQDLWQDKSIAYGGADVKAWANMICQAVWWIHENFVLHRDIKSNNILIAADNSLKLADFGLARSFANPEADMTYNVITRFYRPPELFLGSSHYGGCVDMWSVGCVIAELACREFFIFSETDLQHLVRICDVFGVPTEAEWPGISKLRFWQEQLENSPPKRPQPMSWWRNKMPLIGDAGIDLVKGLLAMDPAKRLDAKQALAHHYWTTAPKPQKRENLPGKGGKAAEKAMGEQLKRVGPEADEEKMSKIARKLDFGAMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C2Z9</accession>
    <name>A0A177C2Z9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1179395</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441557">
        <property type="protein sequence ID" value="OAG01289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031654.1">
        <property type="nucleotide sequence ID" value="XM_018180414.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C2Z9"/>
    <dbReference type="GeneID" id="28763900"/>
    <dbReference type="InParanoid" id="A0A177C2Z9"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG01289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="142" mass="14901" checksum="E70F03994831909E" modified="2016-09-07" version="1">MSPQRLQGGGQHGPAMLSFIVAAYTALDRAPRACRFATAPDARRGRGRHRQREDARTEALGRPPPSGPVPGTSLPASHHGAHTSTLRAAPPSMRHPKSQRHAPAPLAAIGLAQTSAASAQSCCCDRCATVQSSRACEQRPIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C379</accession>
    <name>A0A177C379_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">PEBP-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1262843</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441557">
        <property type="protein sequence ID" value="OAG01846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032211.1">
        <property type="nucleotide sequence ID" value="XM_018185180.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C379"/>
    <dbReference type="STRING" id="1460663.A0A177C379"/>
    <dbReference type="GeneID" id="28768666"/>
    <dbReference type="InParanoid" id="A0A177C379"/>
    <dbReference type="OrthoDB" id="10251855at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00457">
        <property type="entry name" value="PEBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.280.10">
        <property type="entry name" value="PEBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008914">
        <property type="entry name" value="PEBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036610">
        <property type="entry name" value="PEBP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049556">
        <property type="entry name" value="PhiB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30289:SF1">
        <property type="entry name" value="PEBP (PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN) FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30289">
        <property type="entry name" value="UNCHARACTERIZED PROTEIN YBCL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01161">
        <property type="entry name" value="PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49777">
        <property type="entry name" value="PEBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG01846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="203" mass="22707" checksum="4E320DFF531278B3" modified="2016-09-07" version="1">MWLLRLLEYCLGRLLYRRRGYDSDLFFNTIPFGNLKPTLRLESPECGPAGARLTNDHSAFGAGRIPHFTWPAAPPSVKEYLFLAEDPDAPLGHANVHGIYLGIPPTTTSLGPVDLEVVRVENGVKVLKNGWTVGQNRRGWVYIPARPPRGHGPHRYFFVLVGLGEKLDLGRMDKVPTKGEVVREIEGKVVAWGVWEGTYESTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C4G4</accession>
    <name>A0A177C4G4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">GPR1/FUN34/YaaH-class plasma membrane protein-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CC84DRAFT_1262263</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acetate uptake transporter (AceTr) (TC 2.A.96) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441556">
        <property type="protein sequence ID" value="OAG02306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032671.1">
        <property type="nucleotide sequence ID" value="XM_018185141.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C4G4"/>
    <dbReference type="STRING" id="1460663.A0A177C4G4"/>
    <dbReference type="GeneID" id="28768627"/>
    <dbReference type="InParanoid" id="A0A177C4G4"/>
    <dbReference type="OrthoDB" id="3648309at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015123">
        <property type="term" value="F:acetate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051633">
        <property type="entry name" value="AceTr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000791">
        <property type="entry name" value="Gpr1/Fun34/SatP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31123">
        <property type="entry name" value="ACCUMULATION OF DYADS PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31123:SF4">
        <property type="entry name" value="PROTEIN ALCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01184">
        <property type="entry name" value="Gpr1_Fun34_YaaH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="63"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="166"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="188"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="226"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAG02306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="279" mass="30338" checksum="61C246C22746FFA1" modified="2016-09-07" version="1">MSDSHKIDHEMKEHNGHSIVGNGVELSRQVTVQLSPEQYERLFFQPSAPRRGDLAKRFANPTLLGLVGFLIPYTSTILTLCGFQGAVAPQTLVGLSGDYYFFGCIAMNLAGLAEFILGNTFPMAVFIIYGSHWGSLAYTQDPIHQTTSAFSELGGATGAAYNSSQGFHNITMAIASFVFFIGTFRVNVFFTLTFFGLVMLFSFIAAADFRIAHAATEVDVEHINRLLHFAGGFGFIGLVCGWYLAILTACEAVGIPCPLPVLDLSSKIFPKKDPNANVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2023-06-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C4M7</accession>
    <name>A0A177C4M7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_217573</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441557">
        <property type="protein sequence ID" value="OAG01748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032113.1">
        <property type="nucleotide sequence ID" value="XM_018185616.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C4M7"/>
    <dbReference type="GeneID" id="28769102"/>
    <dbReference type="InParanoid" id="A0A177C4M7"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG01748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="211" mass="23143" checksum="82B9DAD065C5CD37" modified="2016-09-07" version="1">MLFPAIPMRVLFDRFPQYERRGTVGNAGLGPLQTIGRPWWVRSVTLGWFCLNTLSPSADVRLLPGAWREIKRQTGAPVAVLSPRQGATALSDTWQRRSLDATGRKACDTRDIEAASRGPSTRVWPSERQQNRASSPEYAAASVYGTLTGLASGYVSPRRARPWTRVLAGLVSQDTHHDKPARTARPRLGQSHKSPPATPSVPAAHATLCRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C4Z9</accession>
    <name>A0A177C4Z9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">GroES-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CC84DRAFT_976069</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441556">
        <property type="protein sequence ID" value="OAG01962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032327.1">
        <property type="nucleotide sequence ID" value="XM_018188029.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C4Z9"/>
    <dbReference type="STRING" id="1460663.A0A177C4Z9"/>
    <dbReference type="GeneID" id="28771515"/>
    <dbReference type="InParanoid" id="A0A177C4Z9"/>
    <dbReference type="OrthoDB" id="10257049at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08249">
        <property type="entry name" value="enoyl_reductase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047122">
        <property type="entry name" value="Trans-enoyl_RdTase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348">
        <property type="entry name" value="HYPOTHETICAL OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348:SF2">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE PROTEIN C2E1P3.01"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="4">
        <location>
            <begin position="51"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAG01962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="407" mass="43729" checksum="8D7E33C9B0E2BC09" modified="2016-09-07" version="1">MPIFSKTRNTSILRFATSLALSTQNTEAQPYLTNQILSTTMPTNSAAWMLGPKQELQVKEAPYPKPGPGEIVVRNRAVAINPIDWILQSQGTAMAFGWIQYPFVFGNDVAGEVVQIGEQVTRLKVGDRVTGQAHSVDKLFNNSAYGGFQQYTILLERNTATIPETMSFESASVLPLAYATAAAGLFEKDQLNLEYPQLDAKATGKTVLVWGGSTSVGLSAIQLALAAGYEVISTSSPRNFDLLKSLGASEVFDYNDPKVVANVVMAMKGRTSAGALAIGEGSMFRCLDVLGRCKGDKHMAMATYPVPSHPKRFALLHTIYCFVTSMISITVKSKLRGITTSFVWGSVAHSPVGEAVYARFLPDALANGKFRAAPEPVVAGEGLEAIQGAIDLQKKGVSARKVVVSLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C5K9</accession>
    <name>A0A177C5K9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_976338</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441556">
        <property type="protein sequence ID" value="OAG01970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032335.1">
        <property type="nucleotide sequence ID" value="XM_018188030.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C5K9"/>
    <dbReference type="GeneID" id="28771516"/>
    <dbReference type="InParanoid" id="A0A177C5K9"/>
    <dbReference type="OrthoDB" id="3766353at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="492"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="277"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="24"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="89"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="496"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG01970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="514" mass="60019" checksum="A4F3E23E1AA858DB" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C6T0</accession>
    <name>A0A177C6T0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RNA-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CC84DRAFT_1167495</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441556">
        <property type="protein sequence ID" value="OAG02447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032812.1">
        <property type="nucleotide sequence ID" value="XM_018179186.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C6T0"/>
    <dbReference type="STRING" id="1460663.A0A177C6T0"/>
    <dbReference type="GeneID" id="28762672"/>
    <dbReference type="InParanoid" id="A0A177C6T0"/>
    <dbReference type="OrthoDB" id="2573941at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12411">
        <property type="entry name" value="RRM_ist3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051847">
        <property type="entry name" value="RNA_proc/Spliceosome_comp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045844">
        <property type="entry name" value="RRM_Ist3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45880">
        <property type="entry name" value="RNA-BINDING MOTIF PROTEIN, X-LINKED 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45880:SF1">
        <property type="entry name" value="RNA-BINDING MOTIF PROTEIN, X-LINKED 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="33"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="112"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="152"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="175"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="192"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="215"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="246"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="279"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAG02447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="328" mass="39272" checksum="CD16826EC1D5956B" modified="2016-09-07" version="1">MNSIRAIQQLNKRELEAGINPEGSWHTDYRDTAFIYIGGLPFELSEGDVITIFSQFGEPVWIRLARDKETGKSKGFGWLKYEDQRSCDLAVDNLGGATIMDRVLKVDHTRYKPKDDEDMGDNTMGEVDVAADEDGGRRKRQRTESESDSDDDRPLLPEEIELEKAIRDLDEEDPMKESMVKRLQEKAESAIKKYKKSKRKEKERKHHRRHRSPRRDRSRDHDRERRRIKDRDSEDEDRRRRKEHRSRREDEDEDRPRRKEHRSRRGDSEGERRHKSSRPPRDGSSDREEVRNSPRDGRDRVRRDHSRERRRYSSEEEDRKRSRSKRSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C790</accession>
    <name>A0A177C790_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_963993</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG03276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033641.1">
        <property type="nucleotide sequence ID" value="XM_018187987.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C790"/>
    <dbReference type="GeneID" id="28771473"/>
    <dbReference type="InParanoid" id="A0A177C790"/>
    <dbReference type="OrthoDB" id="5144514at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006771">
        <property type="entry name" value="CetA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04681">
        <property type="entry name" value="Bys1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008057902" evidence="1">
        <location>
            <begin position="18"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG03276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="205" mass="20682" checksum="EFF3079CE8A4D2B9" modified="2016-09-07" version="1">MVQTSFITLLLPALALAAPWAAPNAPASSAAYSTAVAQPTSTSLPSTTGGKVTFKNNCDYDVTYEQLCPCGSSDGSGTISAGATWSDSISDCSGGNTALKLFKDGGSKPMQFEYGIQSGNIWYDMSFIDCVSGSDDFSQCAGSAWSMGAADSCPTYSCSGGSECCIQGYCDPTASVASEQPVGACGANQGFSASSVGVSIEICGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C7A5</accession>
    <name>A0A177C7A5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cloroperoxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CC84DRAFT_1206881</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the chloroperoxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG03523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033888.1">
        <property type="nucleotide sequence ID" value="XM_018182062.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C7A5"/>
    <dbReference type="STRING" id="1460663.A0A177C7A5"/>
    <dbReference type="GeneID" id="28765548"/>
    <dbReference type="InParanoid" id="A0A177C7A5"/>
    <dbReference type="OrthoDB" id="407298at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.489.10">
        <property type="entry name" value="Chloroperoxidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000028">
        <property type="entry name" value="Chloroperoxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036851">
        <property type="entry name" value="Chloroperoxidase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33577:SF7">
        <property type="entry name" value="HEME HALOPEROXIDASE FAMILY PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33577">
        <property type="entry name" value="STERIGMATOCYSTIN BIOSYNTHESIS PEROXIDASE STCC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01328">
        <property type="entry name" value="Peroxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47571">
        <property type="entry name" value="Cloroperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51405">
        <property type="entry name" value="HEME_HALOPEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 10" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008057827" evidence="8">
        <location>
            <begin position="20"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="Heme haloperoxidase family profile" evidence="9">
        <location>
            <begin position="22"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAG03523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="264" mass="28658" checksum="AE4502196C5AE0BE" modified="2016-09-07" version="1">MRSTSFVAAATLLAGLVRGQGSVEDWHPPTKGDVRGPCPMLNSLANHGFLPHSGKGIKLNDTIHALGEALNIGQDIAIDLFGFAAMTNPEPNATEFSLENLGRHNVLEHDASLSRADFDVTGDSVSFNRDAYDETRKFWTSESITVKQAAAARLARYNTSQTTNPKYTMSPLGDRFSAGESAAYLLVLGDISTATAPRKFVEYLFLNERLPAAEGWKKPSHVFTPTDLATGIDLIYNATGASAEDLKKMRARSKSELHGGSWRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C7J6</accession>
    <name>A0A177C7J6_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">EthD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1219774</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the tpcK family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG02829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033194.1">
        <property type="nucleotide sequence ID" value="XM_018183110.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C7J6"/>
    <dbReference type="STRING" id="1460663.A0A177C7J6"/>
    <dbReference type="GeneID" id="28766596"/>
    <dbReference type="InParanoid" id="A0A177C7J6"/>
    <dbReference type="OrthoDB" id="2519291at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009799">
        <property type="entry name" value="EthD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07110">
        <property type="entry name" value="EthD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EthD" evidence="2">
        <location>
            <begin position="13"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG02829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="143" mass="16410" checksum="09471E9ADEC5115B" modified="2016-09-07" version="1">MVQALICLFSKRDDISFREFRDAMENRFVPLLEKLTGPLFPLTYTRRYIAQDGNDRERHRSGPLGLPSLVVGEADSITWDALVESTFEDDLHLQQFMAFINESEAAEELMECETSFSDSSKLRIIVMENNVSVNKTRGLKTWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C865</accession>
    <name>A0A177C865_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_865644</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG03745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034110.1">
        <property type="nucleotide sequence ID" value="XM_018187700.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C865"/>
    <dbReference type="GeneID" id="28771186"/>
    <dbReference type="InParanoid" id="A0A177C865"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG03745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="128" mass="14692" checksum="7220F2EE0D8A4C4C" modified="2016-09-07" version="1">MPKVGKFEPSTVVTMLLYPAIVVLYSVLACTKLPRHDPRYSALSMTPYVRDHRIWPSATASWPRLCRPGIFQLFFSIGTNRKQMTIQADRRLCARIRYQNMHSVTCMQGGLYTVLRISHAPNTHPRVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C8M5</accession>
    <name>A0A177C8M5_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_1249331</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG03905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034270.1">
        <property type="nucleotide sequence ID" value="XM_018184281.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C8M5"/>
    <dbReference type="GeneID" id="28767767"/>
    <dbReference type="InParanoid" id="A0A177C8M5"/>
    <dbReference type="OrthoDB" id="3799841at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="255"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="236"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="238"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="250"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAG03905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="335" mass="37009" checksum="327AD344A1C7A00B" modified="2016-09-07" version="1">MSEDTDYHWLLSEPGLVDSASGGFALDSHRHNLSVIAARTAPAYHNNASPSIANDLSSNILTPYNTSLEGLLTNTCPATGFNVINTVQNLPSIPDLTVTCSQLGEISLDDPTHTSPSRFASSCRLHFDPQRLYPDTFYVDTIPSHCPTTLHGLSFETPSSSALCFVDDGQHAPEILGNVDYSEGFEAAAPPNQLENLGLDSLISPWCDLTFDEGQSINVGWLPDHLLNPSMLYPVGESSSASPQSSQSSTRERRFPCPHKPCDKVFGSNNDLERHLGTRKHRKDVGNWSERANRYPCKVTVCKRNNVGFARKDHYINHLRRMHQGLELDEDDLYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C8P0</accession>
    <name>A0A177C8P0_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Adenosine kinase</fullName>
            <shortName evidence="11">AK</shortName>
            <ecNumber evidence="4 11">2.7.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Adenosine 5'-phosphotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CC84DRAFT_1219331</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">ATP dependent phosphorylation of adenosine and other related nucleoside analogs to monophosphate derivatives.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>adenosine + ATP = AMP + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20824"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16335"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Purine metabolism; AMP biosynthesis via salvage pathway; AMP from adenosine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the carbohydrate kinase PfkB family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.20" evidence="4 11"/>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG04114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034479.1">
        <property type="nucleotide sequence ID" value="XM_018183074.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C8P0"/>
    <dbReference type="FunCoup" id="A0A177C8P0">
        <property type="interactions" value="1272"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177C8P0"/>
    <dbReference type="GeneID" id="28766560"/>
    <dbReference type="InParanoid" id="A0A177C8P0"/>
    <dbReference type="OrthoDB" id="432447at2759"/>
    <dbReference type="UniPathway" id="UPA00588">
        <property type="reaction ID" value="UER00659"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004001">
        <property type="term" value="F:adenosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044209">
        <property type="term" value="P:AMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006144">
        <property type="term" value="P:purine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01168">
        <property type="entry name" value="adenosine_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1190.20:FF:000014">
        <property type="entry name" value="ADO1p Adenosine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001805">
        <property type="entry name" value="Adenokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002173">
        <property type="entry name" value="Carboh/pur_kinase_PfkB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45769">
        <property type="entry name" value="ADENOSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45769:SF3">
        <property type="entry name" value="ADENOSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00989">
        <property type="entry name" value="ADENOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00584">
        <property type="entry name" value="PFKB_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 11 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 11" id="KW-0660">Purine salvage</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carbohydrate kinase PfkB" evidence="12">
        <location>
            <begin position="26"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR601805-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OAG04114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="344" mass="37069" checksum="B6D9C39020BBF29B" modified="2016-09-07" version="1">MAKGNFELLALENPLLDIQGVGDEKLLEKYGLKANDAILAEEKHLGLFEDLIQNYNAVLIAGGAAQNSARGAQYILPEDSTVYIGCVGKDKYGQTLEDINKKAGVKTVYRYDEKAPTGRCGVVITGQNRSLCTDLAAANLYNVEHLKQPEVWKYVEGAKFFYVGGYHLTVSVPAILAIAEHAAANNKTFVLNLSAPFISQFFKDQLDSVIPYVDILIGNESEAAAYAESHDIASKDVKEIAKEIAKLPKKNSKKERTVVFTQGTDATITVTGSEAAEYPVHAISSDKINDTNGAGDAFAGGFLAGIVAGDNLKAAVDKGQWLAKLSIQELGPSYPEPRQTYTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C9C0</accession>
    <name>A0A177C9C0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Class I glutamine amidotransferase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1097575</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG03320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033685.1">
        <property type="nucleotide sequence ID" value="XM_018174721.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C9C0"/>
    <dbReference type="STRING" id="1460663.A0A177C9C0"/>
    <dbReference type="GeneID" id="28758207"/>
    <dbReference type="InParanoid" id="A0A177C9C0"/>
    <dbReference type="OrthoDB" id="543156at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03139">
        <property type="entry name" value="GATase1_PfpI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052158">
        <property type="entry name" value="INH-QAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43130">
        <property type="entry name" value="ARAC-FAMILY TRANSCRIPTIONAL REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43130:SF15">
        <property type="entry name" value="THIJ_PFPI FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_5G14240)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DJ-1/PfpI" evidence="1">
        <location>
            <begin position="7"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG03320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="231" mass="24850" checksum="58A1CE4ABAED20F1" modified="2016-09-07" version="1">MAAKTPKHVAVILFPGFQLLDITGPLDTLNILSRSTPLRLSILAATLDPVSTALPISTPYLSTLTPSSPPDSPFAQSIVPTHTFDTAPAGIEVLIIPGGFGSRAEENVTPVVEFVQAAYPTLTYLLTVCTGSAIVAKSGVLDGRRATSNKKAFAWVKAQNAEVKWVAKARWVVDGNVWTSSGVAAGIDMIYAWVEDIWGTDVAEELADSSEYERNRDSKKDRFAERWGATD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C9T5</accession>
    <name>A0A177C9T5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Flavo protein-like protein oxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CC84DRAFT_872033</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the flavoredoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG03881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034246.1">
        <property type="nucleotide sequence ID" value="XM_018187734.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C9T5"/>
    <dbReference type="STRING" id="1460663.A0A177C9T5"/>
    <dbReference type="GeneID" id="28771220"/>
    <dbReference type="InParanoid" id="A0A177C9T5"/>
    <dbReference type="OrthoDB" id="10250990at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002563">
        <property type="entry name" value="Flavin_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33798:SF5">
        <property type="entry name" value="FLAVIN REDUCTASE LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33798">
        <property type="entry name" value="FLAVOPROTEIN OXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01613">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00903">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0288">FMN</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavin reductase like" evidence="6">
        <location>
            <begin position="83"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="16"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAG03881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="294" mass="32090" checksum="04F7CEA9C63E6A30" modified="2016-09-07" version="1">MAEGKADAEAAIQRNPHPDFKGVEASRPDFEADRAVHFVKTPKPDWKPGQGANNAEGLSKKHREIDPYAEGRPAIHNYKLLISGVVPRPVGFVSTISGDGKSTNLAPFSYFNMISHDPPLFVLGFAGGVLNAKDTLANLLKTGECTLNIISQDFIEAANYTSLNAPEDVSEWTFSGLHPAKSSIVKPDRVQEAVFNIEAKLIKSMEWESKATPGKKTGVTVIVEGVNFWVREDAVDEAGVLIDPAVLRPICRLGGITYGRVTDLFELPRPQYNDIVKDPETEKLAKPKADGQLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C9V6</accession>
    <name>A0A177C9V6_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Alpha/beta-hydrolase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1188618</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG04166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034531.1">
        <property type="nucleotide sequence ID" value="XM_018180997.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C9V6"/>
    <dbReference type="FunCoup" id="A0A177C9V6">
        <property type="interactions" value="31"/>
    </dbReference>
    <dbReference type="GeneID" id="28764483"/>
    <dbReference type="InParanoid" id="A0A177C9V6"/>
    <dbReference type="OrthoDB" id="10250441at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11440">
        <property type="entry name" value="LECITHIN-CHOLESTEROL ACYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="375"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="689"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="739"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="247"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="258"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="706"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="752"/>
            <end position="761"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG04166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="911" mass="98902" checksum="7C9D524DBB2E0794" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CA95</accession>
    <name>A0A177CA95_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Amino acid transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_884501</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG04051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034416.1">
        <property type="nucleotide sequence ID" value="XM_018187782.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CA95"/>
    <dbReference type="FunCoup" id="A0A177CA95">
        <property type="interactions" value="13"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CA95"/>
    <dbReference type="GeneID" id="28771268"/>
    <dbReference type="InParanoid" id="A0A177CA95"/>
    <dbReference type="OrthoDB" id="2417308at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015101">
        <property type="term" value="F:organic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000046">
        <property type="entry name" value="Amino-acid permease, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF14">
        <property type="entry name" value="GABA PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="62"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="155"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="184"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="225"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="262"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="315"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="364"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="392"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="431"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="464"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="507"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAG04051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="527" mass="56829" checksum="3923CF7831E850E7" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CAH6</accession>
    <name>A0A177CAH6_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_1177716</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG03767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034132.1">
        <property type="nucleotide sequence ID" value="XM_018180298.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CAH6"/>
    <dbReference type="STRING" id="1460663.A0A177CAH6"/>
    <dbReference type="GeneID" id="28763784"/>
    <dbReference type="InParanoid" id="A0A177CAH6"/>
    <dbReference type="OrthoDB" id="4491390at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053175">
        <property type="entry name" value="DHMBA_Reg_Transcription_Factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38791:SF13">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38791">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="10"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="56"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAG03767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="554" mass="61697" checksum="5768BF2836EDBD81" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CB66</accession>
    <name>A0A177CB66_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Jacalin-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_795987</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG04566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034931.1">
        <property type="nucleotide sequence ID" value="XM_018187441.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CB66"/>
    <dbReference type="GeneID" id="28770927"/>
    <dbReference type="InParanoid" id="A0A177CB66"/>
    <dbReference type="OrthoDB" id="3758675at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.100.10.30">
        <property type="entry name" value="Jacalin-like lectin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.15.10">
        <property type="entry name" value="Proaerolysin, chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001229">
        <property type="entry name" value="Jacalin-like_lectin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036404">
        <property type="entry name" value="Jacalin-like_lectin_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01419">
        <property type="entry name" value="Jacalin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56973">
        <property type="entry name" value="Aerolisin/ETX pore-forming domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51101">
        <property type="entry name" value="Mannose-binding lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008057966" description="Jacalin-type lectin domain-containing protein" evidence="1">
        <location>
            <begin position="24"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="Jacalin-type lectin" evidence="2">
        <location>
            <begin position="37"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG04566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="379" mass="40695" checksum="380EBBD94F66730C" modified="2016-09-07" version="1">MFFNPRSLLLGAAALFMSGLANAADCSNGPWTNVLYIGGQGGGEWCNTKYDAGIVVTGMEVWASNKAVRAVQLYYSDGSNSGMVGKLDDIGEHQRIDWDPSKDSISQLKTWGNGNGKYLGRVYLRLKSGGELNVGKDTDGQNVYETDVQSGIMLGAFGRSGDSIDGMGVLFLKSKVSKVTIEDVAFADNVDSLNERMQGLNTMIIDYADHKNNQVNATDDFSFSKKQARTVTKTYTTTAALTFGITEAVEVSGELLGIGGKSTTTLKFETTLTDSSSEATADTAELTYQTSTTVPPGGKVYCRATAMSGVYKGSYSANVKIWLEDGSDFSFAQGGELDQVTWSQASSECQNDPFTDDLPTAEAPISIENLDKRAMKFIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CBC9</accession>
    <name>A0A177CBC9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_799973</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG04636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035001.1">
        <property type="nucleotide sequence ID" value="XM_018187454.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CBC9"/>
    <dbReference type="GeneID" id="28770940"/>
    <dbReference type="InParanoid" id="A0A177CBC9"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG04636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="136" mass="15126" checksum="991C6516709F626B" modified="2016-09-07" version="1">MLSRRMHACIFDLFAGTRTFFNRPLLYVRHTLVPFVVPSATLSSASVLGILGFLSSRLPRRLTRQLTSSRNTPAWINFNRNGTCCTDLHFLRGKQKSKSASSRSLGMPSCQGVLVATKPALETTNTTLRPQQPTFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CBE2</accession>
    <name>A0A177CBE2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1177102</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG04974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035339.1">
        <property type="nucleotide sequence ID" value="XM_018180264.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CBE2"/>
    <dbReference type="GeneID" id="28763750"/>
    <dbReference type="InParanoid" id="A0A177CBE2"/>
    <dbReference type="OrthoDB" id="10601405at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="223"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="406"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="409"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="454"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="467"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG04974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="608" mass="66680" checksum="5C42E305B9D77880" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2023-06-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CBN9</accession>
    <name>A0A177CBN9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1177183</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG05074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035439.1">
        <property type="nucleotide sequence ID" value="XM_018180272.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CBN9"/>
    <dbReference type="GeneID" id="28763758"/>
    <dbReference type="InParanoid" id="A0A177CBN9"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG05074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="181" mass="18742" checksum="E27827B2FF1B05B3" modified="2016-09-07" version="1">MNHTVASWDAPVAEPAEFSSTVTPSAATAATPLCCLPWRASVLPACELQHGGSSQCWPAACSRSCSLSTTVTVLGARAWQRRQAAAVQAASQTAATLNTAPRLASPLLPGCVPGAFAAQPGSGGRQQARRERGGSSRHRAAPLHGLLFPVRLAYTGSACPPLRRRTASPARPSQLRGLSPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CBQ7</accession>
    <name>A0A177CBQ7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytosine deaminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1206259</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG04621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034986.1">
        <property type="nucleotide sequence ID" value="XM_018182023.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CBQ7"/>
    <dbReference type="STRING" id="1460663.A0A177CBQ7"/>
    <dbReference type="GeneID" id="28765509"/>
    <dbReference type="InParanoid" id="A0A177CBQ7"/>
    <dbReference type="OrthoDB" id="408702at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052717">
        <property type="term" value="F:tRNA-specific adenosine-34 deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002100">
        <property type="term" value="P:tRNA wobble adenosine to inosine editing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01285">
        <property type="entry name" value="nucleoside_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11079:SF203">
        <property type="entry name" value="CMP_DCMP-TYPE DEAMINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11079">
        <property type="entry name" value="CYTOSINE DEAMINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008057978" evidence="1">
        <location>
            <begin position="20"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="2">
        <location>
            <begin position="44"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG04621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="236" mass="25326" checksum="8FB0A25E8E6016C5" modified="2016-09-07" version="1">MMSVRSFFAVALALPLALAHQHHIRSDPSTLAQTPLAINGIPPSTRAHWMRKANEALQDVHGDPCPFGAFGAVIVNHTAPGLGELVCIGANSNRQKGDPTLHGEIAAIQNCSAVLTSPWGPYNLSTTAALAAFTQLSLYTNAESCPMCASAIRWAGFKEYVYGTSIDTLVEKGWGQIRISSMEVFRESYDLGTATKLIGEVLTNETDVYFGWQYDLEAECPEGCGRVGSSCQAGDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CCQ0</accession>
    <name>A0A177CCQ0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FAD/NAD(P)-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1093664</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG04579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034944.1">
        <property type="nucleotide sequence ID" value="XM_018174526.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CCQ0"/>
    <dbReference type="STRING" id="1460663.A0A177CCQ0"/>
    <dbReference type="GeneID" id="28758012"/>
    <dbReference type="InParanoid" id="A0A177CCQ0"/>
    <dbReference type="OrthoDB" id="202203at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004174">
        <property type="term" value="F:electron-transferring-flavoprotein dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43735">
        <property type="entry name" value="APOPTOSIS-INDUCING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43735:SF24">
        <property type="entry name" value="NUCLEOTIDE-DISULPHIDE OXIDOREDUCTASE AMID-LIKE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17180)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="1">
        <location>
            <begin position="67"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG04579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="462" mass="50374" checksum="4204627A36C3853F" modified="2016-09-07" version="1">MRLQAISDVLNPISPLANLSLSAPHRVLVIGCAYGGLSAVVNLLDCDKGKARQSYYPDAPDFKEKRSRNGVEITVLDERDGYFHSVGAPLAHTVPKHTVNMWKRFSQTNELRSERNLKFKHGSLKRVDPEAKVAEWLDRSGETQHQAYDYLIMATGLKRHWPAVPKSGSYEEYLKDGKAFVSKIVGGDPRKPQEGRRVVIIGAGAVGIEFAGEIKSHYPSINVTLIHSRDQVLSSEPLPSDVKDKVKDILIEEGVDVVTGSRAAITELPSGEFEVKLANGNVLIADFVIDSTRKGEPTTDPLPEACLNKDKEVKVNLDLSFQDTIPNAASHFGVGDVVEWSGIKRAGSAMVMGQTAAHNIYAAILNSEKTHGSSGEQYKPLKLNKWEPVIGIAIGKQCLTWGAEAGMKYGVEVMQGYFGDDLGWAGNLKYIGLTDVEEEKESQKPEAVKMGPVGVQEISAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CCQ8</accession>
    <name>A0A177CCQ8_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Terpene synthase</fullName>
            <ecNumber evidence="4">4.2.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CC84DRAFT_1094171</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the terpene synthase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.-" evidence="4"/>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG04589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034954.1">
        <property type="nucleotide sequence ID" value="XM_018174551.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CCQ8"/>
    <dbReference type="STRING" id="1460663.A0A177CCQ8"/>
    <dbReference type="GeneID" id="28758037"/>
    <dbReference type="InParanoid" id="A0A177CCQ8"/>
    <dbReference type="OrthoDB" id="6921389at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010333">
        <property type="term" value="F:terpene synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034686">
        <property type="entry name" value="Terpene_cyclase-like_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35201:SF4">
        <property type="entry name" value="BETA-PINACENE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35201">
        <property type="entry name" value="TERPENE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19086">
        <property type="entry name" value="Terpene_syn_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU366034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAG04589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="391" mass="45086" checksum="56505EF1A713614C" modified="2016-09-07" version="1">MDFKYSDVLDSGTYRDDGLANGIPFRIHKDPYSEIAGSLRAQKDWNSTVSPVYDYQGGLGEPYSFIRATIPECIPERLEIISYANEYAFLYDDEMENLDLKNFKEGRDDMLHVFRDDALNEKVHGTVRPEKKLQAQILAEMMAIDRARAITTMKAWAQFVELASRTRSQPFETLDEYLPSRAIDAGELFWYGMLTFAMALTIPANELDLCMKLARPGYAAISLTNDLYSWRKEREDADKAGQDYVFNAVWVVMQERKCTESTAIKICQEEIKRHLSEFEENIESPNTKTLSRDAQAYLHAVRLSHVGNLVWSIYCPRYHRGAYVPTTLQRKADELIPFSDKRLALPTQFGNVASRFFDTIFKFFISPFHQVFHTSGRRLLIQRLRGLVTKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CD31</accession>
    <name>A0A177CD31_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1218056</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG04620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034985.1">
        <property type="nucleotide sequence ID" value="XM_018182961.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CD31"/>
    <dbReference type="STRING" id="1460663.A0A177CD31"/>
    <dbReference type="GeneID" id="28766447"/>
    <dbReference type="InParanoid" id="A0A177CD31"/>
    <dbReference type="OrthoDB" id="4586300at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="321"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="388"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="321"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="337"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="349"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="430"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="469"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG04620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="488" mass="56019" checksum="B5F642154E43BA53" modified="2016-09-07" version="1">MASDENDPRRNRSRDRDQFDEHNPFIAFRRFADSHVSSLLNTVFTLPATIANYKNVHVAREHCLFGRADSAKCEQLHELEEETARVIAECRELYRAGNVEQALDRGEALLQLNHAADELRKQIVEGGQGSSPAERRAGLIPEARDGNSRTELVERVANEKGQQWGWSWDWGFPKPFDADEDIADRRDRCRRWRRRREESMLTNTQAAEQRDAAEDRSMFPDQQSWVEQQRFLHQLDEALLPIFQELFRRESSETADVYDMAGNSNVAAELVRVGVPRDAFEDLLRSQNGYPLMPQEKLGQSDHLLHENWCRRFFDRTDRGFVGRPSRPEYPKRVPWEGEETAEEPNYEYAHDHEDQHDEPPSPKTKQGGWSSGMPETEMEAYERLLGPTPAFGSDAQTEGRPSVLSTLTTTERTVHPDGTVTTKVVLKKRFNDGREESSETVHTERGQDSAGEPSDSPSSVWEAAAQHKPQEQARKDNDKKTGWFWSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CF38</accession>
    <name>A0A177CF38_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CC84DRAFT_1119501</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG05946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036311.1">
        <property type="nucleotide sequence ID" value="XM_018175553.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CF38"/>
    <dbReference type="STRING" id="1460663.A0A177CF38"/>
    <dbReference type="GeneID" id="28759039"/>
    <dbReference type="InParanoid" id="A0A177CF38"/>
    <dbReference type="OrthoDB" id="654211at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051059">
        <property type="entry name" value="VerF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626">
        <property type="entry name" value="MIP31509P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626:SF13">
        <property type="entry name" value="RESPIRATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="8">
        <location>
            <begin position="214"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="133"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="486"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="146"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="748"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAG05946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="748" mass="84005" checksum="0D3A54DED0E51B6C" modified="2016-09-07" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CGX2</accession>
    <name>A0A177CGX2_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Kinetochore complex Sim4 subunit Fta1-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1091965</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG06099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036464.1">
        <property type="nucleotide sequence ID" value="XM_018174423.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CGX2"/>
    <dbReference type="GeneID" id="28757909"/>
    <dbReference type="InParanoid" id="A0A177CGX2"/>
    <dbReference type="OrthoDB" id="8864979at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025204">
        <property type="entry name" value="CENP-L"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13092">
        <property type="entry name" value="CENP-L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="334"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="344"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG06099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="394" mass="43126" checksum="A61731EED69820C3" modified="2016-09-07" version="1">MADVPPYPLYGRSYLLYRVSPLHHGDAPLLREPALNTHAKRLREQLKGDNVRGVDVDFAATEGALPNLGPLDACSWDVIGDDDAWIDRHRQLLHPDASQLTTVVPAEHARGIHVSLDYETQSYNALLLRDPSSTAAPDGFTSLPLLLVKMPSAIRDIFLNYIRTSFDAHVAPLRLSSAFVTSTLETYFRRLTASTSTQTVQDVIRQLQVQLSFPTATTLLRHLDVTMAGRDVPGFLSRGRLLRNAKDRPFTAALAAYMREHLALDISHPKVRISRISCASFVLATDRLKLMAPDIADVSIVDSDTPEGSAGELAVQDFYASLVKEATGTGKFLSEDLTMDRRSSTPSSSTSASASRRKRAVSNVAAGSRTSKRSKAREKENRDGVLGDAEMADA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CGZ7</accession>
    <name>A0A177CGZ7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CC84DRAFT_1164760</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG06501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036866.1">
        <property type="nucleotide sequence ID" value="XM_018178554.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CGZ7"/>
    <dbReference type="STRING" id="1460663.A0A177CGZ7"/>
    <dbReference type="GeneID" id="28762040"/>
    <dbReference type="InParanoid" id="A0A177CGZ7"/>
    <dbReference type="OrthoDB" id="5392646at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048401">
        <property type="entry name" value="SLS1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032741">
        <property type="entry name" value="Sls1_KH-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048400">
        <property type="entry name" value="SLS1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37919:SF2">
        <property type="entry name" value="EXPERA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37919">
        <property type="entry name" value="PROTEIN CBG05606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14611">
        <property type="entry name" value="KH_SLS1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20778">
        <property type="entry name" value="SLS1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20776">
        <property type="entry name" value="SLS1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SLS1 N-terminal" evidence="3">
        <location>
            <begin position="145"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="SLS1 first KH" evidence="2">
        <location>
            <begin position="287"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="SLS1 C-terminal" evidence="4">
        <location>
            <begin position="456"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="777"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="812"/>
            <end position="821"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF20778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAG06501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="878" mass="98619" checksum="872A72A8E8F35A5B" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CH62</accession>
    <name>A0A177CH62_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Membrane-associated proteins in eicosanoid and glutathione metabolism</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CC84DRAFT_743941</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG06047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036412.1">
        <property type="nucleotide sequence ID" value="XM_018187270.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CH62"/>
    <dbReference type="GeneID" id="28770756"/>
    <dbReference type="InParanoid" id="A0A177CH62"/>
    <dbReference type="OrthoDB" id="2122304at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.550">
        <property type="entry name" value="Membrane associated eicosanoid/glutathione metabolism-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023352">
        <property type="entry name" value="MAPEG-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001129">
        <property type="entry name" value="Membr-assoc_MAPEG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35371:SF1">
        <property type="entry name" value="BLR7753 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35371">
        <property type="entry name" value="INNER MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01124">
        <property type="entry name" value="MAPEG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161084">
        <property type="entry name" value="MAPEG domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAG06047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="155" mass="17451" checksum="47F8CFC806104065" modified="2016-09-07" version="1">MFDSINLSIASLPFTLLLSALPHWYTIYLAQSQKVQGGWTNQNPRAFVARLNAKAASGKKLSEVEETILRGQAAQQNGFEWWGVWGVAVVFGYLMKEPKASMDYYTMVHVGARVAYNYLYLRTSRRKTSYLRTVAFWAASYPSVAILCRAAKVLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CHR1</accession>
    <name>A0A177CHR1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1205847</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG06317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036682.1">
        <property type="nucleotide sequence ID" value="XM_018182000.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CHR1"/>
    <dbReference type="STRING" id="1460663.A0A177CHR1"/>
    <dbReference type="GeneID" id="28765486"/>
    <dbReference type="InParanoid" id="A0A177CHR1"/>
    <dbReference type="OrthoDB" id="9451547at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35043:SF8">
        <property type="entry name" value="DUF4220 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35043">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="60"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="351"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG06317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="380" mass="42506" checksum="81D5E6844D75B7DF" modified="2016-09-07" version="1">MNHTELNARVAWQSGPKKRGGFSILWTGLALIITCTWTTLHLNVPGLYDTSKTQLLRKVKWTFIMVIFPEFVLARAIVELKTALDDDVKMAGQAEQMRRLGWCVHPSRSALWIQRVLKKLNFPLSVAQDSDVRDEEDARSCRAPVMSEGSAMNGDPTTSDRTPGTDNDITDDDLPTHDNVPRTCYRSVENLPARKQNFSFSDQTDAEAAFHPARRNCNDHKCYLWTLTHTVFANMGGLMLPLHDGCEITYTGRFLTSGTPGVAGIPRDNHFTEDDIVDKSNGDGFVRGIWLLQILRLLLDLIARAYQKYPMTPLEIITASFAALSFTTVIVQSKKPLDVRKPLDTKTEALLLSMLTGSTILFSTIHCGAWAYEFPSLVGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CI22</accession>
    <name>A0A177CI22_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Amino acid transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CC84DRAFT_1091935</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG06518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036883.1">
        <property type="nucleotide sequence ID" value="XM_018174422.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CI22"/>
    <dbReference type="STRING" id="1460663.A0A177CI22"/>
    <dbReference type="GeneID" id="28757908"/>
    <dbReference type="InParanoid" id="A0A177CI22"/>
    <dbReference type="OrthoDB" id="5982228at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050598">
        <property type="entry name" value="AminoAcid_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785:SF353">
        <property type="entry name" value="METHIONINE TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="139"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="183"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="208"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="289"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="340"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="389"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="420"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="449"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="483"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAG06518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="593" mass="65351" checksum="FCC22CE57A826ED1" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CII5</accession>
    <name>A0A177CII5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CC84DRAFT_1116369</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG06640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037005.1">
        <property type="nucleotide sequence ID" value="XM_018175459.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CII5"/>
    <dbReference type="GeneID" id="28758945"/>
    <dbReference type="InParanoid" id="A0A177CII5"/>
    <dbReference type="OrthoDB" id="6499973at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF130">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="95"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="125"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="160"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="184"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="214"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="255"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="293"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="323"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="347"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="384"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="411"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="24"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAG06640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="445" mass="47550" checksum="552CABD38D6D15E9" modified="2016-09-07" version="1">MPPLDIEHATQGAKEQDFSNDNSTAKEIHHDEPLNPTPSNAPSSIAPPPAPNGGLKAWSQPLAAHLVIINCWGYISSFGFFQSYYTNAFQVEPSAISWIGSVQILLIYFVGTFSGRALDAGYFRVVVGVGFALQVVGVFATSGATAYWQLFLAQGICKGLGDGLVFCPTVALVATYFTTKRSLAIGVMACGGATGGIIFPLIAQQLLLRVGFGWTVRTMGFVILFDALVFLSIARPRLPPRKVGPIVEWSAFKDPAFSLFCCGMFLVLWAVFFAYFYISSFGRDILHVDPSTSLNLLLVLNAIGVPARILCNLIADKLGPVNTLIPAVLAAGILIFGWIGIHALPSLYVFCVIYGFFGGGIQSLFPAACASLTTDLKKMGVRTGMCFSFVSVACLTGPPIAGALIQRDDGGYVYAQIFGGVALIGGTLTLMAAKFVRSRHVMARI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CIJ5</accession>
    <name>A0A177CIJ5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1174601</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG06650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037015.1">
        <property type="nucleotide sequence ID" value="XM_018180104.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CIJ5"/>
    <dbReference type="GeneID" id="28763590"/>
    <dbReference type="InParanoid" id="A0A177CIJ5"/>
    <dbReference type="OrthoDB" id="5372385at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG06650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="135" mass="15678" checksum="98C980B9F1DFF195" modified="2016-09-07" version="1">MPSHWTAIRRLAYADDAATVRLSDTGASRLLDHLLCSMVQNAEVYFHLCNTPAWIRARLHAWVRPFERLRFVKSKIISRINYWLAGTLLGISIRYGEYEPIWARNVDMEERLPRISVACAKSAPPRSFRDEHHTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CIQ1</accession>
    <name>A0A177CIQ1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1088636</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG06729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037094.1">
        <property type="nucleotide sequence ID" value="XM_018174263.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CIQ1"/>
    <dbReference type="STRING" id="1460663.A0A177CIQ1"/>
    <dbReference type="GeneID" id="28757749"/>
    <dbReference type="InParanoid" id="A0A177CIQ1"/>
    <dbReference type="OrthoDB" id="4186885at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="164"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="306"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG06729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="350" mass="38805" checksum="DF3B0AD5FABAE563" modified="2016-09-07" version="1">MRREYEDDARSRASTMSTLNGDDLDFGFPEKTPTNKTFSADRSIPPTAAPAARKAMGPLESQLAALMDKVSQIEKKNPVASVTPDDYAAMKARLETLEAEKRTWQKRHEAIWALRDEDVANNIKIRGVLAKTRRELEAMTKLRDEDLVNVQAVRIKLAEATKQVDRLKSQGPAASGRTSPMRGGRPPSMMLERRDTTDLFAAAKAAALEQRALEMEKRNTDLLHQIETLKGGANIDDLNRMTAHEAWKSEVATISAKLKAKDAEIAELRAAKSMAAPAPSGGTSAAAGAVAWHRVEAIHEEHANYRERMGGKLAVLRAEKEGLQKELHRKEDECHELEVRVQSLQRRMGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CIX5</accession>
    <name>A0A177CIX5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1163103</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG06799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037164.1">
        <property type="nucleotide sequence ID" value="XM_018178176.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CIX5"/>
    <dbReference type="STRING" id="1460663.A0A177CIX5"/>
    <dbReference type="GeneID" id="28761662"/>
    <dbReference type="InParanoid" id="A0A177CIX5"/>
    <dbReference type="OrthoDB" id="3784821at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="293"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="51"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG06799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="330" mass="34385" checksum="E0E03A49C0554521" modified="2016-09-07" version="1">MDTAVATEPIPKKRGRPRKVVSEDAPAVEPKTGVRKASTKTAAAEKKEAAPNKVAKATKTATKTTTKSTTKTTTKAAPAKATKATKAAAPSKTAPAPQTSAAPKAPAPTKAASTPDAEEHIVETPQVADKPTPVTPSTSKILEQVYKTGTVKPPPPASPAPAAQEILLPTGGAANVVIEQPAPAAAMKPSLPSEPIQPTPTPTYTPPTSSSAPPPPPPPPPPQHSIPISRPTPTSALRKATTIPLPLHPLNPSKPATPRPKPISPADLEKAAIERDINEGRMPRKYQGAARRVTAIMVGIPVILVVGWDLYKRWDGEVRKKFGEERVAGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CIX8</accession>
    <name>A0A177CIX8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1163088</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG06780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037145.1">
        <property type="nucleotide sequence ID" value="XM_018178171.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CIX8"/>
    <dbReference type="STRING" id="1460663.A0A177CIX8"/>
    <dbReference type="GeneID" id="28761657"/>
    <dbReference type="InParanoid" id="A0A177CIX8"/>
    <dbReference type="OrthoDB" id="288942at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG06780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="191" mass="22956" checksum="5D71579C0EF1A075" modified="2016-09-07" version="1">MSGYLSTNCFIHPRANWFKPEHWARIQHYHVFGQMYLLGQGMNGLFRNRFDVCLPTTMTLTLRYTDWWDWETNAPIYPIRQDRFFPLRYMWLPPTVQRMTVEFENIESKIKELDAVVNEMFSRHYHWVWRRRDGKNLKVCGRGVEGDGVETWRWNGPTTFGYRSQKFPHHGDGPTMGYVVKVVTWEVVDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CJ63</accession>
    <name>A0A177CJ63_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">separase</fullName>
            <ecNumber evidence="2">3.4.22.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CC84DRAFT_1143059</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>All bonds known to be hydrolyzed by this endopeptidase have arginine in P1 and an acidic residue in P4. P6 is often occupied by an acidic residue or by a hydroxy-amino-acid residue, the phosphorylation of which enhances cleavage.</text>
            <dbReference type="EC" id="3.4.22.49"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.4.22.49" evidence="2"/>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG06898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037263.1">
        <property type="nucleotide sequence ID" value="XM_018176391.1"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CJ63"/>
    <dbReference type="GeneID" id="28759877"/>
    <dbReference type="InParanoid" id="A0A177CJ63"/>
    <dbReference type="OrthoDB" id="10255632at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051307">
        <property type="term" value="P:meiotic chromosome separation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005314">
        <property type="entry name" value="Peptidase_C50"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030397">
        <property type="entry name" value="SEPARIN_core_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12792">
        <property type="entry name" value="EXTRA SPINDLE POLES 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12792:SF0">
        <property type="entry name" value="SEPARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03568">
        <property type="entry name" value="Separin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51700">
        <property type="entry name" value="SEPARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase C50" evidence="6">
        <location>
            <begin position="1943"/>
            <end position="2053"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="45"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="110"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="248"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1382"/>
            <end position="1401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1501"/>
            <end position="1532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="2103"/>
            <end position="2125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="112"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="130"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="165"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="256"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAG06898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="2190" mass="242343" checksum="2DB04B9810CD28A7" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CJA1</accession>
    <name>A0A177CJA1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1175385</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG07614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037979.1">
        <property type="nucleotide sequence ID" value="XM_018180150.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CJA1"/>
    <dbReference type="GeneID" id="28763636"/>
    <dbReference type="InParanoid" id="A0A177CJA1"/>
    <dbReference type="OrthoDB" id="5426707at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="28"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG07614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="123" mass="13456" checksum="0EB438713E46360C" modified="2016-09-07" version="1">MPLTSTRRTHHTTAPRTTRTTRTKPSLKTRLMGAPRTGTRTSARRAPATTTTTTTTKTTRTTHGAGHHGATTTHHHKRHATMGDKVSGALMKLRGSLTRRPGLKAAGTRRMHGTDGRNARRVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CJG2</accession>
    <name>A0A177CJG2_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL3m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CC84DRAFT_1163791</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG07674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038039.1">
        <property type="nucleotide sequence ID" value="XM_018178339.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CJG2"/>
    <dbReference type="FunCoup" id="A0A177CJG2">
        <property type="interactions" value="842"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CJG2"/>
    <dbReference type="GeneID" id="28761825"/>
    <dbReference type="InParanoid" id="A0A177CJG2"/>
    <dbReference type="OrthoDB" id="274683at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000004">
        <property type="entry name" value="50S ribosomal protein L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.810:FF:000001">
        <property type="entry name" value="50S ribosomal protein L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.810">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01325_B">
        <property type="entry name" value="Ribosomal_uL3_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000597">
        <property type="entry name" value="Ribosomal_uL3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019927">
        <property type="entry name" value="Ribosomal_uL3_bac/org-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03625">
        <property type="entry name" value="L3_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11229">
        <property type="entry name" value="50S RIBOSOMAL PROTEIN L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11229:SF8">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL3M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00297">
        <property type="entry name" value="Ribosomal_L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="48"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAG07674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="321" mass="33882" checksum="5421E9536447A0B7" modified="2016-09-07" version="1">MPPMAPLNWGLLPPSFLLPSSTRSLLPLIPLSAAPSHTTVRTIKSVNTPRPDRFAHHPKKPALNSTSRAALARKAPTTPLRTGLLAQKRGMTAVFDPETGRRTACTVLQLDRNEVVAHKTRDKNGYWAVQVGAGHKSIDNTTKPMLGHFAVAGVEPKRWVMEFKVKGKEGLGVGVGEHVGASWFSVGQWVDVKGISRGMGFEGGMKRHGFSGQPASHGQSLMHRGMGSAGGSQGSGSRVLPGKRMAGNMGNESVTVKNLKVLQVDEANGIVVVNGCVPGPKNQIIKVQDAMGKPWPAGPMKLADISPAVAAETAEAATTPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CJR9</accession>
    <name>A0A177CJR9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transcription factor TAFII-31</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CC84DRAFT_1044429</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF9 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG07784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038149.1">
        <property type="nucleotide sequence ID" value="XM_018173399.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CJR9"/>
    <dbReference type="FunCoup" id="A0A177CJR9">
        <property type="interactions" value="440"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CJR9"/>
    <dbReference type="GeneID" id="28756885"/>
    <dbReference type="InParanoid" id="A0A177CJR9"/>
    <dbReference type="OrthoDB" id="341924at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046695">
        <property type="term" value="C:SLIK (SAGA-like) complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd07979">
        <property type="entry name" value="HFD_TAF9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003162">
        <property type="entry name" value="TFIID-31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051431">
        <property type="entry name" value="TFIID_subunit_9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48068">
        <property type="entry name" value="TAF9 RNA POLYMERASE II, TATA BOX-BINDING PROTEIN (TBP)-ASSOCIATED FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48068:SF4">
        <property type="entry name" value="TATA-BOX BINDING PROTEIN ASSOCIATED FACTOR 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02291">
        <property type="entry name" value="TFIID-31kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAG07784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="132" mass="14811" checksum="B77769A2342A3072" modified="2016-09-07" version="1" fragment="single">DTGTSKRPRDARLIHLVLANMGVHAYTERVPLQLLDFAYRYTNGILSDAVSYEGPQANVGKKAAPKDDEGVSLNALRTAIHARAQQQFSSVLPKEFMTEVASERNRVALPRVEREWGLRLPPERYCFTGVGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CJU0</accession>
    <name>A0A177CJU0_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Beta/gamma crystallin 'Greek key' domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1163306</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG07057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037422.1">
        <property type="nucleotide sequence ID" value="XM_018178231.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CJU0"/>
    <dbReference type="STRING" id="1460663.A0A177CJU0"/>
    <dbReference type="GeneID" id="28761717"/>
    <dbReference type="InParanoid" id="A0A177CJU0"/>
    <dbReference type="OrthoDB" id="2910287at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.20.10">
        <property type="entry name" value="Crystallins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008058381" description="Beta/gamma crystallin 'Greek key' domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG07057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="115" mass="12381" checksum="7A9BA78477F8881D" modified="2016-09-07" version="1">MLIPTILTFLTLFTTALARPTAELANVYVCEHINWGGACVNVLYAIDSGDCVSLDGTASSIRPDKGFSCTFYKNGSCRTFDGSASLKLQDPGSADLTKEAGEWNDAARGFQCFRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CL05</accession>
    <name>A0A177CL05_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Rab-GAP TBC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CC84DRAFT_1059252</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">May act as a GTPase-activating protein for Rab family protein(s).</text>
    </comment>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG07986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038351.1">
        <property type="nucleotide sequence ID" value="XM_018173566.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CL05"/>
    <dbReference type="STRING" id="1460663.A0A177CL05"/>
    <dbReference type="GeneID" id="28757052"/>
    <dbReference type="InParanoid" id="A0A177CL05"/>
    <dbReference type="OrthoDB" id="294251at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF10">
        <property type="entry name" value="GROWTH HORMONE-REGULATED TBC PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="4">
        <location>
            <begin position="580"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="233"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="303"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="418"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="477"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="877"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="55"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="108"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="145"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="233"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="335"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="362"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="913"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="925"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00043879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAG07986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="925" mass="103628" checksum="3A0C7D8022188E6F" modified="2016-09-07" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CLD0</accession>
    <name>A0A177CLD0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_714014</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG07752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038117.1">
        <property type="nucleotide sequence ID" value="XM_018187132.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CLD0"/>
    <dbReference type="GeneID" id="28770618"/>
    <dbReference type="InParanoid" id="A0A177CLD0"/>
    <dbReference type="OrthoDB" id="5314997at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG07752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="164" mass="18634" checksum="B2160EA23AE4D596" modified="2016-09-07" version="1">MLDALIRAIMKQVDALHDYELGQGPCLTLLQLFEGRLRNSLLSKRNSRYLVKFVHQAGHYLRYSSITLGTWRRLACLEQSSQPRRHCHSLCRCITCWCGRNDNLCFGRRSRSPACQLPSVRSRMLRTIVTPNGGESLARKLARVSTKGVIELDYTASLLSKIAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CLP2</accession>
    <name>A0A177CLP2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CC84DRAFT_1141130</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MCM10 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038798.1">
        <property type="nucleotide sequence ID" value="XM_018176313.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CLP2"/>
    <dbReference type="STRING" id="1460663.A0A177CLP2"/>
    <dbReference type="GeneID" id="28759799"/>
    <dbReference type="InParanoid" id="A0A177CLP2"/>
    <dbReference type="OrthoDB" id="202825at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000174">
        <property type="entry name" value="DNA replication licensing factor mcm10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040184">
        <property type="entry name" value="Mcm10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055065">
        <property type="entry name" value="OB_MCM10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015408">
        <property type="entry name" value="Znf_Mcm10/DnaG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13454">
        <property type="entry name" value="PROTEIN MCM10 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13454:SF11">
        <property type="entry name" value="PROTEIN MCM10 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22379">
        <property type="entry name" value="OB_MCM10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09329">
        <property type="entry name" value="zf-primase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MCM10 OB-fold" evidence="10">
        <location>
            <begin position="332"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="domain" description="Zinc finger Mcm10/DnaG-type" evidence="9">
        <location>
            <begin position="483"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="92"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="169"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="534"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="591"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="683"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="66"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="105"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="120"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="140"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="194"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="265"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="539"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="723"/>
            <end position="738"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF09329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF22379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OAG08433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="780" mass="85649" checksum="5B36A54C1E25A80C" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CLS0</accession>
    <name>A0A177CLS0_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1087926</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG07800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038165.1">
        <property type="nucleotide sequence ID" value="XM_018174225.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CLS0"/>
    <dbReference type="STRING" id="1460663.A0A177CLS0"/>
    <dbReference type="GeneID" id="28757711"/>
    <dbReference type="InParanoid" id="A0A177CLS0"/>
    <dbReference type="OrthoDB" id="194443at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG07800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="149" mass="17518" checksum="E3BB04BA38E7E166" modified="2016-09-07" version="1" fragment="single">FEIFYDWLYTRTIYTPTEEGRIPLTFDSIIFAYVFGDAHQSPEFCNAAINALIQKCDQDDVLPLYQLNYAYENTLHDNLLRKYLTHDAVACYNFEVFQVDADSYPREFMMEVILASRELECAPRCMASGENWARLLQKRTCDYHDHSNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CNB6</accession>
    <name>A0A177CNB6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">L domain-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_1194600</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038755.1">
        <property type="nucleotide sequence ID" value="XM_018181354.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CNB6"/>
    <dbReference type="STRING" id="1460663.A0A177CNB6"/>
    <dbReference type="GeneID" id="28764840"/>
    <dbReference type="InParanoid" id="A0A177CNB6"/>
    <dbReference type="OrthoDB" id="676979at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025875">
        <property type="entry name" value="Leu-rich_rpt_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050216">
        <property type="entry name" value="LRR_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051:SF1">
        <property type="entry name" value="RAS SUPPRESSOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12799">
        <property type="entry name" value="LRR_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="165"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="322"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="28"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="50"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="91"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="322"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAG08390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="987" mass="107853" checksum="BF021D9A12D611F4" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CP34</accession>
    <name>A0A177CP34_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">FAD/NAD(P)-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CC84DRAFT_1194772</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039015.1">
        <property type="nucleotide sequence ID" value="XM_018181368.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CP34"/>
    <dbReference type="STRING" id="1460663.A0A177CP34"/>
    <dbReference type="GeneID" id="28764854"/>
    <dbReference type="InParanoid" id="A0A177CP34"/>
    <dbReference type="OrthoDB" id="16820at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000156">
        <property type="entry name" value="Salicylate hydroxylase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050493">
        <property type="entry name" value="FAD-dep_Monooxygenase_BioMet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789:SF316">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="9"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAG08650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="423" mass="46457" checksum="0AE41C7DC1945B8C" modified="2016-09-07" version="1">MLTAPPKRVAIIGAGLSGLTLALALHRHGIACTLYELRRPSVSSSGALMLSPNALRILDTLGLYGRLSAQGYNFETIAYKNQAEVTTDRYYLGDEKTYGYKALRVYRQTLLTELRVMAKQLQIPITYGVKFSHIISEDDSGVSFAFTDGTVASADILIGADGIHSTVRKYIAPGVVPKYSGQVAITCAIPISKLEIPKGIEYEMPVAIHGKNGAFVMAPQNVDGSEVLAGTQRAYPEQDRAGWDALLADKDRLLALFRTGIEDWPQIVKSALNNVPIDSLAIWPYYVVPKLERWFSSGKRVIILGDAAHAIPPTAGQGASQGFEDVFTLAALLPHLSEKMPLNKAITYWKHMRQERVDKVIKLTLQLNNTRLPQAERKKLEAGQTWVSGESGQLAWLYNAKVEEDVQAWIIALMLESGYANVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CP70</accession>
    <name>A0A177CP70_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Eukaryotic translation initiation factor 3 subunit D</fullName>
            <shortName evidence="5">eIF3d</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CC84DRAFT_1257560</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">mRNA cap-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. In the eIF-3 complex, eif3d specifically recognizes and binds the 7-methylguanosine cap of a subset of mRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="5">The RNA gate region regulates mRNA cap recognition to prevent promiscuous mRNA-binding before assembly of eif3d into the full eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the eIF-3 subunit D family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039137.1">
        <property type="nucleotide sequence ID" value="XM_018184744.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CP70"/>
    <dbReference type="STRING" id="1460663.A0A177CP70"/>
    <dbReference type="GeneID" id="28768230"/>
    <dbReference type="InParanoid" id="A0A177CP70"/>
    <dbReference type="OrthoDB" id="16538at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071540">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex, eIF3e"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071541">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex, eIF3m"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098808">
        <property type="term" value="F:mRNA cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002191">
        <property type="term" value="P:cap-dependent translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03003">
        <property type="entry name" value="eIF3d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007783">
        <property type="entry name" value="eIF3d"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12399">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12399:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05091">
        <property type="entry name" value="eIF-3_zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016281">
        <property type="entry name" value="EIF-3_zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5 7" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="103"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="RNA gate" evidence="5">
        <location>
            <begin position="302"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="48"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="107"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="163"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAG08772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="575" mass="64041" checksum="2CB4BDFA6C0C8DE3" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CQL4</accession>
    <name>A0A177CQL4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Major facilitator superfamily transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CC84DRAFT_1137752</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG09813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040178.1">
        <property type="nucleotide sequence ID" value="XM_018176161.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CQL4"/>
    <dbReference type="FunCoup" id="A0A177CQL4">
        <property type="interactions" value="17"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CQL4"/>
    <dbReference type="GeneID" id="28759647"/>
    <dbReference type="InParanoid" id="A0A177CQL4"/>
    <dbReference type="OrthoDB" id="5215911at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000224">
        <property type="entry name" value="MFS transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF34">
        <property type="entry name" value="PROTEIN HOL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="68"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="105"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="135"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="195"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="224"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="380"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="418"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="451"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="480"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="514"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="269"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="13"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAG09813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="558" mass="61825" checksum="4177D6E25D41FDD0" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CQV7</accession>
    <name>A0A177CQV7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 17">Postreplication repair E3 ubiquitin-protein ligase RAD18</fullName>
            <ecNumber evidence="5 17">2.3.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">RING-type E3 ubiquitin transferase RAD18</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">CC84DRAFT_1057221</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">E3 RING-finger protein, member of the UBC2/RAD6 epistasis group. Associates to the E2 ubiquitin conjugating enzyme UBC2/RAD6 to form the UBC2-RAD18 ubiquitin ligase complex involved in postreplicative repair (PRR) of damaged DNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 17">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="17">Interacts with E2 UBC2, forming a complex with ubiquitin ligase activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 17">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 17">Belongs to the RAD18 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="5 17"/>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG09895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040260.1">
        <property type="nucleotide sequence ID" value="XM_018173549.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CQV7"/>
    <dbReference type="FunCoup" id="A0A177CQV7">
        <property type="interactions" value="293"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CQV7"/>
    <dbReference type="GeneID" id="28757035"/>
    <dbReference type="InParanoid" id="A0A177CQV7"/>
    <dbReference type="OrthoDB" id="9049620at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097505">
        <property type="term" value="C:Rad6-Rad18 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006301">
        <property type="term" value="P:DNA damage tolerance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006513">
        <property type="term" value="P:protein monoubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000172">
        <property type="entry name" value="E3 ubiquitin-protein ligase RAD18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039577">
        <property type="entry name" value="Rad18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004580">
        <property type="entry name" value="Rad18_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003034">
        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00599">
        <property type="entry name" value="rad18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14134">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RAD18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14134:SF2">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RAD18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02037">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13923">
        <property type="entry name" value="zf-C3HC4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00513">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50800">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 17" id="KW-0227">DNA damage</keyword>
    <keyword evidence="14 17" id="KW-0234">DNA repair</keyword>
    <keyword evidence="13 17" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15 17" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 17" id="KW-0808">Transferase</keyword>
    <keyword evidence="11 17" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="12 17" id="KW-0862">Zinc</keyword>
    <keyword evidence="10 16 17" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="19">
        <location>
            <begin position="41"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="SAP" evidence="20">
        <location>
            <begin position="251"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="110"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="228"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="356"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="448"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="18">
        <location>
            <begin position="145"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="18">
        <location>
            <begin position="172"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="357"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="371"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="21">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="21">
        <location>
            <position position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00015551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU368093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="OAG09895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="471" mass="52590" checksum="282F1D5B1ABAB950" modified="2016-09-07" version="1" fragment="single">PAAPLLPATLAMESSFELPDSTDWLTTSLPAFEPLEAALRCEVCKEFYNNPVITSCAHTFCSLCIRRCIAIDGKCPACKSACQADKLQPNIAVREIATKFQEARPKALELARAKEDNDDGETAAPASGRKRKRETADGEDEGRRTTRSRHTRRSTRLGNESITDDMPVVIPDSDEEKEDEYVPEGMVPCPICKKPMKEEAVFNHIPICPAAQDDTGTRKTRSRKDDAFPNHLQARMKENGPPPTRLSGLHYPMLNDKALRKKLQELGIPTWGTKQQLMKRHQEWLNIYNSNCDASDEARKPKRELLRELDEWERTQGGRATAKESHIMRKDFDGQNHATAHKNQFDDLIANARKRAKDISRASEEKVESTPAGSSGTDPQPAQADNLEATSDPPHPYENNEAALSSIRQKVEEANRTDSAFPPLSHNTKDANIKAAQDAGMYQEEIPLGFAPENPLGSPTRKVPMFRMPEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CR89</accession>
    <name>A0A177CR89_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CC84DRAFT_1235584</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG09731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040096.1">
        <property type="nucleotide sequence ID" value="XM_018183851.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CR89"/>
    <dbReference type="STRING" id="1460663.A0A177CR89"/>
    <dbReference type="GeneID" id="28767337"/>
    <dbReference type="InParanoid" id="A0A177CR89"/>
    <dbReference type="OrthoDB" id="5365785at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051439">
        <property type="entry name" value="XlnR/Xlr1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47663">
        <property type="entry name" value="XYLANOLYTIC TRANSCRIPTIONAL ACTIVATOR XLNR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47663:SF1">
        <property type="entry name" value="XYLANOLYTIC TRANSCRIPTIONAL ACTIVATOR XLNR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="829"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="8">
        <location>
            <begin position="534"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="130"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="553"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="141"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="580"/>
            <end position="589"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAG09731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="931" mass="102380" checksum="9784DA9C36B05725" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CRF9</accession>
    <name>A0A177CRF9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CC84DRAFT_1137167</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG09470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039835.1">
        <property type="nucleotide sequence ID" value="XM_018176138.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CRF9"/>
    <dbReference type="STRING" id="1460663.A0A177CRF9"/>
    <dbReference type="GeneID" id="28759624"/>
    <dbReference type="InParanoid" id="A0A177CRF9"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11065">
        <property type="entry name" value="CYP64-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF4">
        <property type="entry name" value="CYTOCHROME P450 98A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0349">Heme</keyword>
    <keyword evidence="4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="26"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="463"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAG09470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="562" mass="64149" checksum="61F02854C69E8586" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CRM6</accession>
    <name>A0A177CRM6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1235915</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG09946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040311.1">
        <property type="nucleotide sequence ID" value="XM_018183868.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CRM6"/>
    <dbReference type="GeneID" id="28767354"/>
    <dbReference type="InParanoid" id="A0A177CRM6"/>
    <dbReference type="OrthoDB" id="3740056at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008058508" evidence="1">
        <location>
            <begin position="18"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG09946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="207" mass="22551" checksum="06778A636C8336A1" modified="2016-09-07" version="1">MFSALVICLFIACSAIAASTGHEVVCGPSSNCEILNCSGTISHHFKRGLGLNSSDYAARFATHEARGDLIKTYITLGKTKIGWGCDQPLGPIFKEGIKKVCGAHGCAEDTSYTKDVSWVDANLARSKPQKRKLELKAKGEYDSQADLDNYIKAFEATATPKTVGTENREWCDAEVSHWMNGGCKEIGTCPMRMFPSFVKIARFRGGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CRV4</accession>
    <name>A0A177CRV4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1193400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG09672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040037.1">
        <property type="nucleotide sequence ID" value="XM_018181295.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CRV4"/>
    <dbReference type="GeneID" id="28764781"/>
    <dbReference type="InParanoid" id="A0A177CRV4"/>
    <dbReference type="OrthoDB" id="2589819at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025494">
        <property type="entry name" value="DUF4385"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14328">
        <property type="entry name" value="DUF4385"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG09672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="157" mass="18557" checksum="6832E14E3E2D98E5" modified="2016-09-07" version="1">MSQTGSKADHMSYRIGRGEQGVLTFEPYSAEILPLWRFKTPAIARQSSKKIYDKFFEYEKQDDFVGMDMCRKFLQMGMTRAKRYANHAGGRKYDKETGKELGRSTNHEGAKEKLEASMIFREVWEKAKTYETYVEKKKIFLKEQKEWDKQQKKEAKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CRX7</accession>
    <name>A0A177CRX7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cytochrome b5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_1213328</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome b5 family. MAPR subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG09951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040316.1">
        <property type="nucleotide sequence ID" value="XM_018182522.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CRX7"/>
    <dbReference type="STRING" id="1460663.A0A177CRX7"/>
    <dbReference type="GeneID" id="28766008"/>
    <dbReference type="InParanoid" id="A0A177CRX7"/>
    <dbReference type="OrthoDB" id="899at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000003">
        <property type="entry name" value="membrane-associated progesterone receptor component 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050577">
        <property type="entry name" value="MAPR/NEUFC/NENF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10281:SF115">
        <property type="entry name" value="BINDING PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G06240)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10281">
        <property type="entry name" value="MEMBRANE-ASSOCIATED PROGESTERONE RECEPTOR COMPONENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="3">
        <location>
            <begin position="29"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAG09951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="131" mass="14538" checksum="8F967AA3BB913EF4" modified="2016-09-07" version="1">MSDSSAPQQKERFAPKQPVNLAPPKDDVITRDYLAKCDGTNEGFPTLVAIKGDVFDVSGKDTYAPGKNYHVFTGKEPNRALGLSSLEPKDCISDYSDLAEDKLQVLNDWHTFFSKRYNIVGRLQPENSASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CSK2</accession>
    <name>A0A177CSK2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CC84DRAFT_1235923</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG09948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040313.1">
        <property type="nucleotide sequence ID" value="XM_018183869.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CSK2"/>
    <dbReference type="GeneID" id="28767355"/>
    <dbReference type="InParanoid" id="A0A177CSK2"/>
    <dbReference type="OrthoDB" id="4161376at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010573">
        <property type="entry name" value="MFS_Str1/Tri12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF195">
        <property type="entry name" value="PEP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06609">
        <property type="entry name" value="TRI12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="54"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="92"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="121"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="146"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="179"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="209"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="250"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="277"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="320"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="356"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="387"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="414"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="447"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="538"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="57"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="12"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAG09948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="579" mass="61617" checksum="5A175401196CA7B1" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2023-06-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CSV4</accession>
    <name>A0A177CSV4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_490830</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040980.1">
        <property type="nucleotide sequence ID" value="XM_018186489.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CSV4"/>
    <dbReference type="GeneID" id="28769975"/>
    <dbReference type="InParanoid" id="A0A177CSV4"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG10615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="165" mass="18173" checksum="0B0B05AB9D657991" modified="2016-09-07" version="1">MKGRKGTVQVARVSIVRKGHACIGSCEACRIFTLSCVAALISQYIHTSKGCSTEDRKVYKMSWVSLLVPAPGRRSRGTRTVCRMDKVAWKRRWDRVAWNSRVEGPGNVAGKCRTGQQCRVGGVSIAMDGCRMGIVRHGRKIVMGIIGENRVGRVGRQTSPVMLAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CT74</accession>
    <name>A0A177CT74_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AMP-binding enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CC84DRAFT_492582</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041098.1">
        <property type="nucleotide sequence ID" value="XM_018186512.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CT74"/>
    <dbReference type="STRING" id="1460663.A0A177CT74"/>
    <dbReference type="GeneID" id="28769998"/>
    <dbReference type="InParanoid" id="A0A177CT74"/>
    <dbReference type="OrthoDB" id="1898221at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016405">
        <property type="term" value="F:CoA-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096:SF149">
        <property type="entry name" value="AMP-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="3">
        <location>
            <begin position="42"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="4">
        <location>
            <begin position="456"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAG10733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="564" mass="60754" checksum="B40B9552D30CB7B1" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CTK0</accession>
    <name>A0A177CTK0_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">G-protein coupled receptors family 3 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_1202646</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040472.1">
        <property type="nucleotide sequence ID" value="XM_018181785.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CTK0"/>
    <dbReference type="GeneID" id="28765271"/>
    <dbReference type="InParanoid" id="A0A177CTK0"/>
    <dbReference type="OrthoDB" id="3210850at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019424">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38848">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 3 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38848:SF3">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 3 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10320">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008058589" description="G-protein coupled receptors family 3 profile domain-containing protein" evidence="3">
        <location>
            <begin position="24"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="78"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="153"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="195"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="278"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="336"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="339"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="359"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAG10107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="371" mass="40882" checksum="CAE1641DFB68D611" modified="2016-09-07" version="1">MVVMAFLWSSYLQSLQLSHGSSASPVHPRSNSVYTDPDYGTSMQGRLAYGLVSFFCLFSLAFVLGIRAKRFEKKKLKFTWLLVHVQTLIALGLVISSSILVVTFGTTTQEQCFSAIMVCVVFYITAKMCLYMFLLERAHVVRAPFIRKRTDDWVWVGGTTLICVTFGAISIWGLITPHAELSLDDGQCRIGLAKVPAYLLLIFDALINAALTVLFVVLLRPVLEFRERTSTCFDDGNPSPSVNRFRQALRQLRSLGFKEDEGTDNFSTSIKIVLWKNVVGSGITFMASAANLIVFFSEKGSQLASVCLVSCMADVTCGALVVHWLTIGSNEEIHVPPRSTRSNHTPSLSSSSTIAAISKPEDIVKPSKPES</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CTZ6</accession>
    <name>A0A177CTZ6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF1446-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1237670</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041056.1">
        <property type="nucleotide sequence ID" value="XM_018183910.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CTZ6"/>
    <dbReference type="GeneID" id="28767396"/>
    <dbReference type="InParanoid" id="A0A177CTZ6"/>
    <dbReference type="OrthoDB" id="10265871at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056362">
        <property type="entry name" value="AtuA-like_ferredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010839">
        <property type="entry name" value="AtuA_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47585">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47585:SF2">
        <property type="entry name" value="DUF1446 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G11420)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07287">
        <property type="entry name" value="AtuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23544">
        <property type="entry name" value="AtuA_ferredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyclic terpene utilisation N-terminal" evidence="1">
        <location>
            <begin position="15"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="domain" description="AtuA-like ferredoxin-fold" evidence="2">
        <location>
            <begin position="517"/>
            <end position="614"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG10691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="627" mass="68874" checksum="B3FCC22DBE15EB42" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CUB4</accession>
    <name>A0A177CUB4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1214372</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG11124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041489.1">
        <property type="nucleotide sequence ID" value="XM_018182627.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CUB4"/>
    <dbReference type="GeneID" id="28766113"/>
    <dbReference type="InParanoid" id="A0A177CUB4"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG11124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="713" mass="80858" checksum="166A048391111E33" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CUM2</accession>
    <name>A0A177CUM2_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF3295 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_486236</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040852.1">
        <property type="nucleotide sequence ID" value="XM_018186464.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CUM2"/>
    <dbReference type="GeneID" id="28769950"/>
    <dbReference type="InParanoid" id="A0A177CUM2"/>
    <dbReference type="OrthoDB" id="5355526at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031930">
        <property type="term" value="P:mitochondria-nucleus signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006808">
        <property type="term" value="P:regulation of nitrogen utilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021711">
        <property type="entry name" value="DUF3295"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053043">
        <property type="entry name" value="Ras-cAMP_regulatory"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28014">
        <property type="entry name" value="NEGATIVE REGULATOR OF RAS-CAMP PATHWAY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28014:SF1">
        <property type="entry name" value="NEGATIVE REGULATOR OF RAS-CAMP PATHWAY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11702">
        <property type="entry name" value="DUF3295"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3295" evidence="2">
        <location>
            <begin position="3"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="505"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG10487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="589" mass="64916" checksum="7E2F41DB4FD71402" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CVG7</accession>
    <name>A0A177CVG7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1224026</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG11236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041601.1">
        <property type="nucleotide sequence ID" value="XM_018183536.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CVG7"/>
    <dbReference type="GeneID" id="28767022"/>
    <dbReference type="InParanoid" id="A0A177CVG7"/>
    <dbReference type="OrthoDB" id="10599498at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG11236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="200" mass="21981" checksum="28C381CF5E8E20E2" modified="2016-09-07" version="1">MLACISVTPDIMSYRKPEADGQRNDCQSEADHGSDGDARLSPYWFDCSYRDFVGTASGLAWAHQSSFTARMPGSCSRLPVWTLLPETCLDSRNSSTLYLFQKTRQICATGKPGCKRAPTDYTYADVAEWLICCRAMIWSTNPNLPRAASAAVGSHINETTLTSLCMPRKYIAFLQLESQQITGSITLTRHAKGPGATRAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CVJ4</accession>
    <name>A0A177CVJ4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CC84DRAFT_500165</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041277.1">
        <property type="nucleotide sequence ID" value="XM_018186544.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CVJ4"/>
    <dbReference type="STRING" id="1460663.A0A177CVJ4"/>
    <dbReference type="GeneID" id="28770030"/>
    <dbReference type="InParanoid" id="A0A177CVJ4"/>
    <dbReference type="OrthoDB" id="310217at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050660">
        <property type="entry name" value="NEK_Ser/Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43671">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE NEK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43671:SF13">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE NEK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="18"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAG10912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="305" mass="34712" checksum="EDE9C76247305D38" modified="2016-09-07" version="1">MDVTRHPNCPRSRFEIVRPITERPGQNNDGIFVVEHVTTGEYCVEKRLKTADVANGYAQREIDVLSQLSGHPNIIQLVDYQLNNDPQLQECDLSARTWTEYCEYGSLRNVVDYLQDSGNPRLSEPLLWHILASLAEAVRYLQQGPKEFPFLSWNTVCHRDIHLGNVFLAAEPAGSNFPRVVLGDFGSSTTVAHTLFGYNSEWAISWFEEFFAPPEFPSYYPESDIYQIGAVLYCLMYGQHSPYYGTAPRLVHGKRGYLDHDIWVRELQFDAPYSDALVDIVSACLCGDVFSRCNIDQLLEMLGKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CVX4</accession>
    <name>A0A177CVX4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial</fullName>
            <shortName evidence="7">Glu-AdT subunit B</shortName>
            <ecNumber evidence="7">6.3.5.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CC84DRAFT_1079155</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>L-glutamyl-tRNA(Gln) + L-glutamine + ATP + H2O = L-glutaminyl-tRNA(Gln) + L-glutamate + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17521"/>
            <dbReference type="Rhea" id="RHEA-COMP:9681"/>
            <dbReference type="Rhea" id="RHEA-COMP:9684"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:78521"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Subunit of the heterotrimeric GatCAB amidotransferase (AdT) complex, composed of A, B and C subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the GatB/GatE family. GatB subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.-" evidence="7"/>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG11386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041751.1">
        <property type="nucleotide sequence ID" value="XM_018173828.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CVX4"/>
    <dbReference type="FunCoup" id="A0A177CVX4">
        <property type="interactions" value="363"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CVX4"/>
    <dbReference type="GeneID" id="28757314"/>
    <dbReference type="InParanoid" id="A0A177CVX4"/>
    <dbReference type="OrthoDB" id="1722066at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030956">
        <property type="term" value="C:glutamyl-tRNA(Gln) amidotransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050567">
        <property type="term" value="F:glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070681">
        <property type="term" value="P:glutaminyl-tRNAGln biosynthesis via transamidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00121">
        <property type="entry name" value="GatB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017959">
        <property type="entry name" value="Asn/Gln-tRNA_amidoTrfase_suB/E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006075">
        <property type="entry name" value="Asn/Gln-tRNA_Trfase_suB/E_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018027">
        <property type="entry name" value="Asn/Gln_amidotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003789">
        <property type="entry name" value="Asn/Gln_tRNA_amidoTrase-B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004413">
        <property type="entry name" value="GatB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017958">
        <property type="entry name" value="Gln-tRNA_amidoTrfase_suB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00133">
        <property type="entry name" value="gatB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004012">
        <property type="entry name" value="PRK05477.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11659">
        <property type="entry name" value="GLUTAMYL-TRNA GLN AMIDOTRANSFERASE SUBUNIT B MITOCHONDRIAL AND PROKARYOTIC PET112-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11659:SF0">
        <property type="entry name" value="GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE SUBUNIT B, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02934">
        <property type="entry name" value="GatB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02637">
        <property type="entry name" value="GatB_Yqey"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00845">
        <property type="entry name" value="GatB_Yqey"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89095">
        <property type="entry name" value="GatB/YqeY motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="Glutamine synthetase/guanido kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01234">
        <property type="entry name" value="GATB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Asn/Gln amidotransferase" evidence="9">
        <location>
            <begin position="441"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="31"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="38"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="55"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="76"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAG11386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="610" mass="67643" checksum="03520D8A3C5C5C1B" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CWB2</accession>
    <name>A0A177CWB2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1203358</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG11107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041472.1">
        <property type="nucleotide sequence ID" value="XM_018181820.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CWB2"/>
    <dbReference type="GeneID" id="28765306"/>
    <dbReference type="InParanoid" id="A0A177CWB2"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG11107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="428" mass="47597" checksum="4E2F6C0F179A5AD1" modified="2016-09-07" version="1">MASSDQPPGVRRRAMSPPSRDGTSATEKLQSISSTTELPNDKIEILPDISRIPETPSQSPPDLECQTADTTATPGPHKPPLTGPPYVRTRAWSFRPFRVCCRKWILSLFAALSASILAHYYLGTCCGISAMSQAVPTHTGAVDTTNQWVPYNCPDGSKTSCKMPPLFRELMEHQASSTDLAQSINAAATSPNKPKYIQYDQRSIEYFIHQNTLAAAKIANAMLKLQKDVQEMQSTVAQSFSTSLSTLFESPHCGLDIAEAFVTNATATWTYFYKHIQSDVRRLQKALDDHVVNLSHIMIHVRYVWQCDDIWQKRGKRRFIGIASYSKTWDCEHLAPSELLSMIDTMLKDAACDMEMLAQYEQLMEKVGPALKERLRKILAVRDQSIEATIEGLDATITGFDAEREICEAGEMLVPGLDINAKDVCGSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CWE8</accession>
    <name>A0A177CWE8_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein PNS1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_1214318</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Probably involved in transport through the plasma membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the CTL (choline transporter-like) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG11059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041424.1">
        <property type="nucleotide sequence ID" value="XM_018182619.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CWE8"/>
    <dbReference type="STRING" id="1460663.A0A177CWE8"/>
    <dbReference type="GeneID" id="28766105"/>
    <dbReference type="InParanoid" id="A0A177CWE8"/>
    <dbReference type="OrthoDB" id="420519at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007603">
        <property type="entry name" value="Choline_transptr-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12385">
        <property type="entry name" value="CHOLINE TRANSPORTER-LIKE (SLC FAMILY 44)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12385:SF88">
        <property type="entry name" value="CHOLINE TRANSPORTER-LIKE PROTEIN CTL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04515">
        <property type="entry name" value="Choline_transpo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="291"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="329"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="359"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="399"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="436"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="467"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="495"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="539"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="647"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="685"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="9"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="47"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="89"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="181"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU368066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAG11059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="756" mass="83615" checksum="7C2DEDA3742442D6" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CWF4</accession>
    <name>A0A177CWF4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">RTA1-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CC84DRAFT_55527</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG11843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042208.1">
        <property type="nucleotide sequence ID" value="XM_018186677.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CWF4"/>
    <dbReference type="STRING" id="1460663.A0A177CWF4"/>
    <dbReference type="GeneID" id="28770163"/>
    <dbReference type="InParanoid" id="A0A177CWF4"/>
    <dbReference type="OrthoDB" id="5384040at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007568">
        <property type="entry name" value="RTA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465:SF15">
        <property type="entry name" value="LIPID TRANSPORTER ATNI-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04479">
        <property type="entry name" value="RTA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="47"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="77"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="146"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="186"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="229"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="270"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="296"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="296"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="320"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAG11843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="343" mass="38026" checksum="FA97477EFD948602" modified="2016-09-07" version="1">MATPTATQSTTGTTSTSTPFCTTAIPGQYGFVPPDACNAQWAYSPSFAAAVAFSALFGMLFIAHFALAILFRKGFSWVMIMGVSWEFIAFVTRALGAHDQQSQAFSFTATLLFLLAPLWVNAYVYMTAGRLIWTYHPNKKVWGFKAISLGKYFVWLDVFSFLVQAVGGLMLSPGASASTMTTGKNIYMTGVGVQQLFILLFFALIVRFQIELQRFERNGAGWLGKRWQWVTYALYAALALITMRIIFRLIEFSAGAGVDNPLPYHEKYALALDAFPMSLAILILAVIHPGLALKGPESEFPSRKERKAEKKQIKAAKKAGKQDRKMARTRGDVSITDVEMNRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CWH0</accession>
    <name>A0A177CWH0_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">polynucleotide adenylyltransferase</fullName>
            <ecNumber evidence="3">2.7.7.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CC84DRAFT_1106435</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the poly(A) polymerase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.19" evidence="3"/>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG11167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041532.1">
        <property type="nucleotide sequence ID" value="XM_018175143.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CWH0"/>
    <dbReference type="STRING" id="1460663.A0A177CWH0"/>
    <dbReference type="GeneID" id="28758629"/>
    <dbReference type="InParanoid" id="A0A177CWH0"/>
    <dbReference type="OrthoDB" id="10263155at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990817">
        <property type="term" value="F:poly(A) RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1140.10">
        <property type="entry name" value="Cyclic phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.590">
        <property type="entry name" value="Poly(A) polymerase predicted RNA binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040459">
        <property type="entry name" value="MJ1316"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011068">
        <property type="entry name" value="NuclTrfase_I-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007012">
        <property type="entry name" value="PolA_pol_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002934">
        <property type="entry name" value="Polymerase_NTP_transf_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10682">
        <property type="entry name" value="POLY A POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10682:SF23">
        <property type="entry name" value="POLYNUCLEOTIDE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13563">
        <property type="entry name" value="2_5_RNA_ligase2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04457">
        <property type="entry name" value="MJ1316"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01909">
        <property type="entry name" value="NTP_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04928">
        <property type="entry name" value="PAP_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55003">
        <property type="entry name" value="PAP/Archaeal CCA-adding enzyme, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81631">
        <property type="entry name" value="PAP/OAS1 substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="11">
        <location>
            <begin position="276"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="domain" description="Polymerase nucleotidyl transferase" evidence="10">
        <location>
            <begin position="658"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="domain" description="Poly(A) polymerase central" evidence="13">
        <location>
            <begin position="782"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="domain" description="MJ1316 RNA cyclic group end recognition" evidence="12">
        <location>
            <begin position="1125"/>
            <end position="1197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="216"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1075"/>
            <end position="1125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="1080"/>
            <end position="1099"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1112"/>
            <end position="1122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF04457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF04928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OAG11167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="1213" mass="136040" checksum="B7340DDD63A8892B" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CWN1</accession>
    <name>A0A177CWN1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Azaphilone pigments biosynthesis cluster protein L N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_37213</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG11448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041813.1">
        <property type="nucleotide sequence ID" value="XM_018185950.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CWN1"/>
    <dbReference type="GeneID" id="28769436"/>
    <dbReference type="InParanoid" id="A0A177CWN1"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031348">
        <property type="entry name" value="PigL_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17111">
        <property type="entry name" value="PigL_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Azaphilone pigments biosynthesis cluster protein L N-terminal" evidence="2">
        <location>
            <begin position="11"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="86"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG11448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="337" mass="38617" checksum="D88AB4D37140EAC6" modified="2016-09-07" version="1">MDPASATVAFVGFAASITTLAAVLFQSCKTLRDLCHDLHNAPQDLHRLLRNAQTLEKVVLQVKRTGAEIANEESMEHIDAYWMNNVKDMERDLEVFNKKVSKLQKSLEKPSITSLQVKARFYKVFSESDIEQYERQLSQHRDTFTMLYSMVSNERSKKIMEELHLQSKKLDRLASSANTFHATMKNELRATQKLLSEENKVVINTVKREVRTLNYRLPNEETILSQLQLHGAELATLAPSSEELLPGYEEPPPTYLEAMTESASSTQVLVSFLHPGLDKRKWLRHQRMVAIQFQDRILAVSGPMVDQNCCSSLLWPQRKRRCYTGHQLEAEAEALQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CWR2</accession>
    <name>A0A177CWR2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_12831</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG11342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041707.1">
        <property type="nucleotide sequence ID" value="XM_018185356.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CWR2"/>
    <dbReference type="GeneID" id="28768842"/>
    <dbReference type="InParanoid" id="A0A177CWR2"/>
    <dbReference type="OrthoDB" id="10554331at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG11342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="149" mass="16209" checksum="BACA5AB2F775F497" modified="2016-09-07" version="1">MAKLRTAHLKRYGKLGDNTCFMSVEQTTMTPGPKLYTALLRALGGNDEAIRVLATESSPGVPRDRAHGSVNASALPVLEVKRSENNIRPFCPGCVVSKLLGFNHHEQLTIDLGSNALGINNDLAQRHRKGGSTASMAFQNQRLHLCYPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CWR9</accession>
    <name>A0A177CWR9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">NADH-quinone oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CC84DRAFT_1200586</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the complex I 23 kDa subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG11267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041632.1">
        <property type="nucleotide sequence ID" value="XM_018181673.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CWR9"/>
    <dbReference type="STRING" id="1460663.A0A177CWR9"/>
    <dbReference type="GeneID" id="28765159"/>
    <dbReference type="InParanoid" id="A0A177CWR9"/>
    <dbReference type="OrthoDB" id="204405at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003954">
        <property type="term" value="F:NADH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.3270:FF:000001">
        <property type="entry name" value="NADH-quinone oxidoreductase subunit I 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01351">
        <property type="entry name" value="NDH1_NuoI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010226">
        <property type="entry name" value="NADH_quinone_OxRdtase_chainI"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01971">
        <property type="entry name" value="NuoI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004538">
        <property type="entry name" value="PRK05888.1-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004539">
        <property type="entry name" value="PRK05888.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10849:SF20">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 8, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10849">
        <property type="entry name" value="NADH DEHYDROGENASE UBIQUINONE IRON-SULFUR PROTEIN 8, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12838">
        <property type="entry name" value="Fer4_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54862">
        <property type="entry name" value="4Fe-4S ferredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-1278">Translocase</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="8">
        <location>
            <begin position="122"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="8">
        <location>
            <begin position="161"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAG11267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="230" mass="25761" checksum="FCB0378C3BC7CE2A" modified="2016-09-07" version="1">MASTRPLTMLARTRPAATLLRPSAFAAGRLPSPATVALFSTTFPRAATPAGPPPPGFRLPPPKKWDEGESALDRAGKYFLLVEMFRGMYILLEQFFRPPYTIMYPFEKGPISPRFRGEHALRRYPTGEERCIACKLCEAICPAQAITIEAEERMDGSRRTTRYDIDMTKCIYCGLCQESCPVDAIVESPNAEYATETREELLYNKEKLLANGDKWEPEIAAAARADAPYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CX39</accession>
    <name>A0A177CX39_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_7485</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG11289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041654.1">
        <property type="nucleotide sequence ID" value="XM_018187283.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CX39"/>
    <dbReference type="STRING" id="1460663.A0A177CX39"/>
    <dbReference type="GeneID" id="28770769"/>
    <dbReference type="InParanoid" id="A0A177CX39"/>
    <dbReference type="OrthoDB" id="3858188at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="233"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="242"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG11289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="278" mass="31681" checksum="2037D7655859277A" modified="2016-09-07" version="1">MSLATSRYAPKTPLESLVQSKAEKLKQDKARTTRLLNRLQWKAESLAVSYVRAIEILRAEVDQNGNIDSRVELRYAFMRATNSKQAESMFKVDFFEFYTLLERYISTSLEIMGVHVSGTAPRTNVNALKYITNPDLHRIRPRALHAFHANLLEALDDPKCPLHISLGNQEVRIQLGIAKDYRNAWKDADEKVSKTGGHNKDDESRKNVNLTDLDLDTMLRYLLAGCEHAHGIVQDRPDADPNSFTSRDFEQQAQQSTSNAMETDDVPFEYMDDAMDLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CX75</accession>
    <name>A0A177CX75_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="7">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CC84DRAFT_1133211</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">PPIase that acts as a histone chaperone. Histone proline isomerase that increases the rate of cis-trans isomerization at prolines on the histone H3 N-terminal tail. Proline isomerization influences H3 methylation thereby regulating gene expression.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Binds to histones H3 and H4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FKBP-type PPIase family. FKBP3/4 subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="7"/>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG11427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041792.1">
        <property type="nucleotide sequence ID" value="XM_018175963.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CX75"/>
    <dbReference type="FunCoup" id="A0A177CX75">
        <property type="interactions" value="546"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CX75"/>
    <dbReference type="GeneID" id="28759449"/>
    <dbReference type="InParanoid" id="A0A177CX75"/>
    <dbReference type="OrthoDB" id="77911at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.50.40:FF:000006">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.340">
        <property type="entry name" value="Nucleoplasmin core domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041232">
        <property type="entry name" value="NPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023566">
        <property type="entry name" value="PPIase_Fpr3/Fpr4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43811:SF19">
        <property type="entry name" value="39 KDA FK506-BINDING NUCLEAR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43811">
        <property type="entry name" value="FKBP-TYPE PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17800">
        <property type="entry name" value="NPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001473">
        <property type="entry name" value="FK506-bp_FPR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase FKBP-type" evidence="9">
        <location>
            <begin position="411"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="57"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="220"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="59"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="91"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="119"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="156"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="220"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="265"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="345"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="397"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAG11427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="497" mass="53799" checksum="19DC97B1DBE526A8" modified="2016-09-07" version="1">MASIPAGVYGLRVPAGGQPIPASVNPNVAFRITMAAIDPTAEVEAGPARATLKLIRIQDDDEDEDDDDDDFDPDNIEELRAKLLADGVLGSEDESDEDEDESEEETNGGPSDPAKSKQAKREALQKKLQEEAAAEEMEIDSITNGVNGKGKGKALDDEDSDESDSEEGDEAEELVLCTLDPEKHWQQTLEITVREGEEIYFSSNGSHDIYLTGNYVAIMDDEDDDDERDLYGLGEDDYDESPDEDELDEELSELDSEEDSLDDLADPRITEVDSEEEAPKLVKADKKGKNKRPAQDEDEGEAMTLDELITKTKAEAPAANGEKPSKKQAKKLKNNEGQAVAAAEPAKEAKKVDTPSSDKKKVQFAKNLEQGPTGSPKVAEAKKEPTKGPRNVGGVTVEDKKEGKGKAAKKGDKIEMRYIGKLKNGKQFDANKKGKPFSFKLGVGEVIKGWDVGVAGMQAGAERRLTIPAKLAYGSKALPGIPANSELIFDIKCISVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CXQ4</accession>
    <name>A0A177CXQ4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF218 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_113303</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042700.1">
        <property type="nucleotide sequence ID" value="XM_018175958.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CXQ4"/>
    <dbReference type="FunCoup" id="A0A177CXQ4">
        <property type="interactions" value="63"/>
    </dbReference>
    <dbReference type="GeneID" id="28759444"/>
    <dbReference type="InParanoid" id="A0A177CXQ4"/>
    <dbReference type="OrthoDB" id="4347at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055323">
        <property type="entry name" value="C57A10.07/YOR238W"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28110">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28110:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG12335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="331" mass="36594" checksum="93A52B0DC1572760" modified="2016-09-07" version="1">MATPATPSRILPKSNFHNANAATNTGVSIAPDAESKGASLAYQRNNDFEHPDHVIPPPDYTGFENLVIVCCHGIFHPDASSPDFPLYSPHDENNWYLADFQKSNPETGKPGEQETFLAHALAGIDALIGELSPDVPNRTLLVMSGGSTKPSLTPLSEARSYYHAALAHELAEGNRGGGRTYQLFSKGRILLEEHAADSFQNLLFSILLFRQTTGRYPKQIRVITHAFKARRFLDLHAPSIRWPSERIQVQGIDPVMSGAEREQTIRGEEKHGFAPWLQDQLGTGDFLASKRRNRGWDEQVAEQLAEGLEVSAKEVVKGTVPEHLPWESTVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CZ73</accession>
    <name>A0A177CZ73_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1160062</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018043168.1">
        <property type="nucleotide sequence ID" value="XM_018177394.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CZ73"/>
    <dbReference type="STRING" id="1460663.A0A177CZ73"/>
    <dbReference type="GeneID" id="28760880"/>
    <dbReference type="InParanoid" id="A0A177CZ73"/>
    <dbReference type="OrthoDB" id="2550114at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39605">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39605:SF1">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="53"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="119"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG12803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="176" mass="19046" checksum="DBE9EB43B29BF033" modified="2016-09-07" version="1">MDVYYFYSYGTAAWMALQAAPMIASPTMIMALLSPEVREPSTLEIYFSRQLGFALLAIGALNILLTGSVPLSSRLSEGATTSATDPKAPYALPTLTITAFFHAALAFYGYTMWTETGVFSFGLGTIGSGFFCAIAMWCILFASSDGRISRKTGADKRTSGFPFKNNQAHSELKKGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CZ95</accession>
    <name>A0A177CZ95_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1159711</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042753.1">
        <property type="nucleotide sequence ID" value="XM_018177305.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CZ95"/>
    <dbReference type="GeneID" id="28760791"/>
    <dbReference type="InParanoid" id="A0A177CZ95"/>
    <dbReference type="OrthoDB" id="2126185at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="114"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="296"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="308"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG12388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="329" mass="37873" checksum="E0627C125E1A301A" modified="2016-09-07" version="1">MCFATLAALSLFTTWYYMYHYFRVSYQAWAMWRSRYDVSQDTMHWGLWLSETSLFREFWETIVVGNARYWWSHQIFFFASGLGLSLEERGMIPARRLEMHANVSGIRRGIKYTWAFMLLGQIVSISFATNLYLLTLLLTPPLPPPSSSAGIYRRQWFGPWLINLLAIVFTIWSAYQLADEHYWYHQTEFMPMLLTPHVALLAMPLLRAVVPQKYLSESNVEFTGTLYKFLWAANNFGGGLLFTRVTAVAYKFSGPRGIWQQMWEHPAVSSVAFDVILCWVTWSAWWATQTHTTSAMPAIGEDEKEGESAAAGSGRADALPETGSAMRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CZG8</accession>
    <name>A0A177CZG8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_124748</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042886.1">
        <property type="nucleotide sequence ID" value="XM_018184236.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CZG8"/>
    <dbReference type="GeneID" id="28767722"/>
    <dbReference type="InParanoid" id="A0A177CZG8"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG12521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="160" mass="17448" checksum="4F5467B66AAD74FF" modified="2016-09-07" version="1">MLGQDTCWKEAYGVAKWGTYGPLCTSVVPLRRLRTAWDKVWCLALGAMSRGCMYGRAVYPRCSQCLARRSCTIPTSQHGTSHHPASLIASATTLHSRVGGQASRTRTWARDALVNHRFEHRRLLPVSTSPSVRNSDPGSSVPRPRPAFAGHGSVHAAGHC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177D0C1</accession>
    <name>A0A177D0C1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_1183592</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG13145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018043510.1">
        <property type="nucleotide sequence ID" value="XM_018180696.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177D0C1"/>
    <dbReference type="GeneID" id="28764182"/>
    <dbReference type="InParanoid" id="A0A177D0C1"/>
    <dbReference type="OrthoDB" id="5593352at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.225.20">
        <property type="entry name" value="Ub domain-containing protein, DC-UbP/UBTD2, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032752">
        <property type="entry name" value="DC-UbP/UBTD2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038169">
        <property type="entry name" value="DC-UbP/UBTD2_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039712">
        <property type="entry name" value="Meu6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039483">
        <property type="entry name" value="Meu6_PH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42073">
        <property type="entry name" value="MEIOTIC EXPRESSION UP-REGULATED PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42073:SF1">
        <property type="entry name" value="MEIOTIC EXPRESSION UP-REGULATED PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15406">
        <property type="entry name" value="PH_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16455">
        <property type="entry name" value="UBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Meiotic expression up-regulated protein 6 PH" evidence="2">
        <location>
            <begin position="90"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="DC-UbP/UBTD2 N-terminal" evidence="3">
        <location>
            <begin position="741"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="230"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="664"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="20"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="251"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="281"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="307"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="338"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="380"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="403"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="465"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="506"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="527"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="544"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="595"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="668"/>
            <end position="693"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF15406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAG13145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="936" mass="99938" checksum="3BD630822E631638" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177D0E0</accession>
    <name>A0A177D0E0_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CC84DRAFT_1212151</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the engrailed homeobox family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042997.1">
        <property type="nucleotide sequence ID" value="XM_018182426.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177D0E0"/>
    <dbReference type="STRING" id="1460663.A0A177D0E0"/>
    <dbReference type="GeneID" id="28765912"/>
    <dbReference type="InParanoid" id="A0A177D0E0"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016586">
        <property type="term" value="C:RSC-type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050720">
        <property type="entry name" value="Engrailed_Homeobox_TFs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24341">
        <property type="entry name" value="HOMEOBOX PROTEIN ENGRAILED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24341:SF6">
        <property type="entry name" value="HOMEOBOX PROTEIN INVECTED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 6 7" id="KW-0371">Homeobox</keyword>
    <keyword evidence="5 6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="9">
        <location>
            <begin position="40"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="6">
        <location>
            <begin position="42"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="233"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="297"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="396"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="442"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="304"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="398"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="476"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="513"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAG12632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="762" mass="82462" checksum="A183A6EF001CD4DE" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177D0F8</accession>
    <name>A0A177D0F8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1212625</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG13183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018043548.1">
        <property type="nucleotide sequence ID" value="XM_018182468.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177D0F8"/>
    <dbReference type="STRING" id="1460663.A0A177D0F8"/>
    <dbReference type="GeneID" id="28765954"/>
    <dbReference type="InParanoid" id="A0A177D0F8"/>
    <dbReference type="OrthoDB" id="3501153at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053008">
        <property type="entry name" value="Phomopsin_biosynth_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35896">
        <property type="entry name" value="IG-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35896:SF3">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG13183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="235" mass="27044" checksum="34835D5013B7A1BF" modified="2016-09-07" version="1">MESPKNSALTTLCDEETFKDFSDVESDDTTLVQLRSRSRVFRPVIILLSVILVLIPLIYFTVATPRRRLKYDQCGTTADEARARGCVFEITGFTWLPRECQDTETEDEFLDYLAENDLNIYRDTKYTDIVPIEEVRLGNGPGFFVRQQYHVTHCQFLLRKLHRAQTSGRMIDGQIMPTHHTVHCGEQTLSVIQDPSWREDAIQLSYTKFPYCGKPGGYNVGWDQDHGRPTAWTNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177D127</accession>
    <name>A0A177D127_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1160127</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018043237.1">
        <property type="nucleotide sequence ID" value="XM_018177416.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177D127"/>
    <dbReference type="GeneID" id="28760902"/>
    <dbReference type="InParanoid" id="A0A177D127"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG12872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="123" mass="13573" checksum="0B787FA9905F04F3" modified="2016-09-07" version="1">MCHSFSFVISHVVFVPRARLLPVHAVSYAAEQLRSGLDATKHTHRSIPGRTEPPCRSLIHLPRYGVGTDNQSARKASMHHGYKSSEICAIIKPFRTTHTPDVSSGVHLVRSSPLKSQPNQAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177D158</accession>
    <name>A0A177D158_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Multidrug resistance protein-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_1136133</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018043322.1">
        <property type="nucleotide sequence ID" value="XM_018176089.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177D158"/>
    <dbReference type="FunCoup" id="A0A177D158">
        <property type="interactions" value="12"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177D158"/>
    <dbReference type="GeneID" id="28759575"/>
    <dbReference type="InParanoid" id="A0A177D158"/>
    <dbReference type="OrthoDB" id="3357846at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015244">
        <property type="term" value="F:fluconazole transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990961">
        <property type="term" value="P:xenobiotic detoxification by transmembrane export across the plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001958">
        <property type="entry name" value="Tet-R_TetA/multi-R_MdtG-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00880">
        <property type="entry name" value="2_A_01_02"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF23">
        <property type="entry name" value="FLUCONAZOLE RESISTANCE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="166"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="202"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="229"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="263"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="297"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="370"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="409"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="452"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="474"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="518"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="542"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="136"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="70"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAG12957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="579" mass="64918" checksum="7745927062621957" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177D1P3</accession>
    <name>A0A177D1P3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CC84DRAFT_1077686</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family. Isoflavone reductase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG13157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018043522.1">
        <property type="nucleotide sequence ID" value="XM_018173766.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177D1P3"/>
    <dbReference type="GeneID" id="28757252"/>
    <dbReference type="InParanoid" id="A0A177D1P3"/>
    <dbReference type="OrthoDB" id="419598at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051609">
        <property type="entry name" value="NmrA/Isoflavone_reductase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706:SF4">
        <property type="entry name" value="NMRA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706">
        <property type="entry name" value="NMRA-LIKE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="4">
        <location>
            <begin position="5"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAG13157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="319" mass="34461" checksum="12F83689B47C9B0F" modified="2016-09-07" version="1">MPAFTVAVAGGTGGIGRALVNGLVQQGKHKVLILSRKSSTLEVDSASISTIATDYTSIPSMISTLQEHKIDVVISALILSSPENSQAQLNLITAATQSGTVTSFLPSEYGIHYTPETLSFHPAARYWLDAAAALRASALRFTRVVFGWTLDHYGIPRVHSYMKPFKYVLDFDARRAAVPGDGTQKVSFLHTTDLARYVAALLEDEGEWPEVSAFVGGVASWGEFVRIAERVTGAKWDVTYDSVEVLEKGEATMLPQPPGAPTEEDYPGMREMVSEFGLMAVRGVLDVSDAGIRNGAFPHIKPMSVEEVVEKAWGRDAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BTX5</accession>
    <name>A0A177BTX5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1105681</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441564">
        <property type="protein sequence ID" value="OAF98863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029229.1">
        <property type="nucleotide sequence ID" value="XM_018175108.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BTX5"/>
    <dbReference type="GeneID" id="28758594"/>
    <dbReference type="InParanoid" id="A0A177BTX5"/>
    <dbReference type="OrthoDB" id="1844152at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAF98863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="59" mass="6577" checksum="C6CFB639CD5D41E8" modified="2016-09-07" version="1" fragment="single">TPSLAAAIIFAVLSALTTFLHNYQMLRTRAWFLIWFILGGLSYIACAYSAYENLGKTCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BUF8</accession>
    <name>A0A177BUF8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1158379</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441564">
        <property type="protein sequence ID" value="OAF98775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029141.1">
        <property type="nucleotide sequence ID" value="XM_018177049.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BUF8"/>
    <dbReference type="STRING" id="1460663.A0A177BUF8"/>
    <dbReference type="GeneID" id="28760535"/>
    <dbReference type="InParanoid" id="A0A177BUF8"/>
    <dbReference type="OrthoDB" id="9451547at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35043:SF8">
        <property type="entry name" value="DUF4220 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35043">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008057366" evidence="1">
        <location>
            <begin position="31"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAF98775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="210" mass="23474" checksum="E9EBA83F02ED71B6" modified="2016-09-07" version="1">MSRVSSSSKLLTQFVLSIAICQSLISVSNAQYAGNNGGRFGIYGFKNGTLPHGNSYRVRGCVEQPNYRGSFDILWVSLVSIGISTYTMLYLNVPAPTDTWIQLVGRRVLWMILGIIRPEFPLNYAAGQWTRAKHSVKAFRDLGYKHTSSHTNEEMAGKQDWDLNPLDFVDENGSGYSANLQAFMKMPVIPPTCPIQRIPNDRFLTNPYGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BUT0</accession>
    <name>A0A177BUT0_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">LysM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1106241</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441574">
        <property type="protein sequence ID" value="OAF98481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018028847.1">
        <property type="nucleotide sequence ID" value="XM_018175136.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BUT0"/>
    <dbReference type="STRING" id="1460663.A0A177BUT0"/>
    <dbReference type="GeneID" id="28758622"/>
    <dbReference type="InParanoid" id="A0A177BUT0"/>
    <dbReference type="OrthoDB" id="5985073at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LysM" evidence="1">
        <location>
            <begin position="237"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAF98481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="410" mass="44714" checksum="E2901B279937F274" modified="2016-09-07" version="1">MYATNRSRSWCILSVLFTIGSLTNFVTAIKLYPSPASLPSQVPAGCRAALSTDITCGPRFILASDLVREIPFNNTFLGDYCSSACSTSFNSFTTNINTRCGNTVYDFGYNNNKTGNDLIAPLKWARDMACLTGTSSIDYCLPKIHNHSVGYCDDCTLKYFAGMLSNAAGARVISEKGFSSIASSCNVSPTKYPHSTITIQKPPPALALDRFLYQNSIDFGCKTLNVGNSVCIRDACKTYTIQANQTCKAIASRLGFTRTELVQWNPILESNCDKLDVLKGRTVCITPPGTKSYSFTPTATWNDTWTWPDGSWVTGPTAGVPLANRTTTLSGEFSMTTETLSLVESPIASLADYFKYCPLTDQIWDDGFDWEGLSTGCTNLLNKYCNPVLTGTPLPSTSFPPNCFPPYPTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BV89</accession>
    <name>A0A177BV89_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glycosyl transferase family 25 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CC84DRAFT_1241084</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 25 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441584">
        <property type="protein sequence ID" value="OAF98457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018028823.1">
        <property type="nucleotide sequence ID" value="XM_018184043.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BV89"/>
    <dbReference type="GeneID" id="28767529"/>
    <dbReference type="InParanoid" id="A0A177BV89"/>
    <dbReference type="OrthoDB" id="47375at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06532">
        <property type="entry name" value="Glyco_transf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050757">
        <property type="entry name" value="Collagen_mod_GT25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002654">
        <property type="entry name" value="Glyco_trans_25"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10730:SF53">
        <property type="entry name" value="GLYCOSYLTRANSFERASE 25 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10730">
        <property type="entry name" value="PROCOLLAGEN-LYSINE,2-OXOGLUTARATE 5-DIOXYGENASE/GLYCOSYLTRANSFERASE 25 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01755">
        <property type="entry name" value="Glyco_transf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyl transferase family 25" evidence="5">
        <location>
            <begin position="112"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="332"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="334"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAF98457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="410" mass="45927" checksum="8A489E6941C8E72E" modified="2016-09-07" version="1">MNGQRRKIRTFLCLVVVLLLVLANFHTSLLAPLSHARQLLGIRAIEILTRTAAGNRTLGFHSIKFINIPTRFDRLDAVRLQAYLSGLDVTEQPAVLPSEINSVGMPPSSNPQDLKPGEKGCWRAHANIWSEIVEKKLPPTLIIESDAAWDIDVRRIMALLNEQFTGLLHQLGSKPIYTHGVEDNMVETDDKKGHQNVQVESVLRENPDDPWHSDHWDILSLGNCFDQQKSPTSYLKYKDPYVPEGKDYFGQKLGKERVVHQSGGFVCTTAYAITQRGAAKLLLRTAFDFNVQVDLIIKDMIADGELVAYTTIPTVMAQWHYVDGLGMEDRGANSDIQGTKGEPSTNNGNEGWGLPMGAEVDMSGWEKAKKAKSVWMVKPSHPDTAFSRMALEVAWDIIFSEEKNIEHRFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BVW7</accession>
    <name>A0A177BVW7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">deuterolysin</fullName>
            <ecNumber evidence="4">3.4.24.39</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CC84DRAFT_1191399</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Preferential cleavage of bonds with hydrophobic residues in P1'. Also 3-Asn-|-Gln-4 and 8-Gly-|-Ser-9 bonds in insulin B chain.</text>
            <dbReference type="EC" id="3.4.24.39"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="15">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M35 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.39" evidence="4"/>
    <dbReference type="EMBL" id="KV441563">
        <property type="protein sequence ID" value="OAF98881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029247.1">
        <property type="nucleotide sequence ID" value="XM_018181180.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BVW7"/>
    <dbReference type="STRING" id="1460663.A0A177BVW7"/>
    <dbReference type="GeneID" id="28764666"/>
    <dbReference type="InParanoid" id="A0A177BVW7"/>
    <dbReference type="OrthoDB" id="412874at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11008">
        <property type="entry name" value="M35_deuterolysin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050414">
        <property type="entry name" value="Fungal_M35_metalloproteases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029463">
        <property type="entry name" value="Lys_MEP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001384">
        <property type="entry name" value="Peptidase_M35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37016">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37016:SF5">
        <property type="entry name" value="DEUTEROLYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14521">
        <property type="entry name" value="Aspzincin_M35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00768">
        <property type="entry name" value="DEUTEROLYSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01351">
        <property type="entry name" value="Aspzincin_M35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0165">Cleavage on pair of basic residues</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 18" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6 18" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="9 16" id="KW-0732">Signal</keyword>
    <keyword evidence="11 15" id="KW-0862">Zinc</keyword>
    <keyword evidence="13" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008057376" description="deuterolysin" evidence="16">
        <location>
            <begin position="18"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="Lysine-specific metallo-endopeptidase" evidence="17">
        <location>
            <begin position="201"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="active site" evidence="14">
        <location>
            <position position="307"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="306"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="310"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="316"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR601384-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR601384-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM01351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="OAF98881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="355" mass="37259" checksum="5BBF5934BE1837F7" modified="2016-09-07" version="1">MLTKALPVALLAGAASAACPLAVSIANADNHIVNVQVTNTGSETLQVFKGNTVFSDHATKDLLVADAAGKALPFNGVYVNYKKTGLSSDSFQKIAAGETVTVSVNAAKSYKLEGVQQAKVSAIQGFRYATGEAAPSALRDLSVCADQTTSSVDVTPDQSTVAAEHISKRSEPFSSRIQKRSITYSSCSTSQTSTLKTSVADAISMAGKAATAAASSADYYTTWFKSTSVASKVQTIYNDVKNVQTTSPEISCTDTYGDCSDGSALLYTVPSDNVIVPCPNNGFWDFPEYASQCSGDDYDKAGSILHEMTHLYGTTDYAYGYTAAQKLSASQAAANADTYEMYAESVRLGGCTVGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BVY0</accession>
    <name>A0A177BVY0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">FAD/NAD(P)-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CC84DRAFT_1169640</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441563">
        <property type="protein sequence ID" value="OAF98891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029257.1">
        <property type="nucleotide sequence ID" value="XM_018179710.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BVY0"/>
    <dbReference type="STRING" id="1460663.A0A177BVY0"/>
    <dbReference type="GeneID" id="28763196"/>
    <dbReference type="InParanoid" id="A0A177BVY0"/>
    <dbReference type="OrthoDB" id="655030at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46972:SF1">
        <property type="entry name" value="FAD DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46972">
        <property type="entry name" value="MONOOXYGENASE ASQM-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="8"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="101"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAF98891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="405" mass="44976" checksum="E91B2F9053412B13" modified="2016-09-07" version="1">MTATTPKIALIGAGPTSLTLAAILHRNAIPFTIYEAASTLRHQGGTLDLHPQTGQQALREAGLWDEFVKHARPESDCMKLVELESGEVFWDENAGDGQSGEETKKSLEDSLKGRPEIDREWLMKITYGALPEESVKWGKKLKEVLPNSMDPKKHDLYFTDGSKEERVDLVVGADGAWSKVRNLLTDVKPHYSGISAVELWHHDVQSEPWLLNYVGAGSCFAFAEGSAILSQRQGDGSLRTYACLRVPETFFDDCGIDWDSEDTARTQFIDRYFSHVSPDLQRVLALSKDRLTPRALYELPIGFSYPHRPGITLIGDAAHLMTPFAGVGVNVGMTDALVLAKEILASCRGEQSVDRAVGAYEKELWPRARKYMEKTAKGKERHFRAGGSKEMADMLRAFHAGQKPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BWG6</accession>
    <name>A0A177BWG6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Yos1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CC84DRAFT_1169736</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the YOS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441563">
        <property type="protein sequence ID" value="OAF99018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029384.1">
        <property type="nucleotide sequence ID" value="XM_018179743.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BWG6"/>
    <dbReference type="FunCoup" id="A0A177BWG6">
        <property type="interactions" value="272"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177BWG6"/>
    <dbReference type="GeneID" id="28763229"/>
    <dbReference type="InParanoid" id="A0A177BWG6"/>
    <dbReference type="OrthoDB" id="15356at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013880">
        <property type="entry name" value="Yos1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15858">
        <property type="entry name" value="IMMEDIATE EARLY RESPONSE 3-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15858:SF0">
        <property type="entry name" value="IMMEDIATE EARLY RESPONSE 3-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08571">
        <property type="entry name" value="Yos1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAF99018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="84" mass="9234" checksum="8DA12085BA814A53" modified="2016-09-07" version="1">MVFFGLGGLLQFSVLLINAIAILSEDRFLARIGWTSSADPGFGGQRDDGIKARLVNLVSSVRTLMRIPLMFINTAMIIYLLIFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BWH1</accession>
    <name>A0A177BWH1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1222836</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441561">
        <property type="protein sequence ID" value="OAF99833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030199.1">
        <property type="nucleotide sequence ID" value="XM_018183424.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BWH1"/>
    <dbReference type="GeneID" id="28766910"/>
    <dbReference type="InParanoid" id="A0A177BWH1"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAF99833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="192" mass="21633" checksum="19CF1C05D6C34FF6" modified="2016-09-07" version="1">MCVLPTFAKGLAAVAPSINNTACTVSNEYLFVQQEPAVPHRRPWTGENTFTWRDISADIAVSMSPCDESVKQVMQMYRTRTIGSVSRYTIQSQALEYGTSALEEEVAIEMIPEDRSDSFKEEEKWERVDSGDTSNDEERHERTKYAGTDCTRSTYMGKAGYSHTVLPKDESSNDSHVGGIQVIITEHFYQQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2023-06-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BWR7</accession>
    <name>A0A177BWR7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_350036</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441560">
        <property type="protein sequence ID" value="OAF99933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030299.1">
        <property type="nucleotide sequence ID" value="XM_018185869.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BWR7"/>
    <dbReference type="GeneID" id="28769355"/>
    <dbReference type="InParanoid" id="A0A177BWR7"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAF99933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="72" mass="8041" checksum="0F4BD46FD98B9E05" modified="2016-09-07" version="1">MRRHERRSRRALHARAVSMLGPLEWLAVVANMIQCVQNVVCRAGLECAVAIQYPQPPSCCPTHDPQYAIPCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BX98</accession>
    <name>A0A177BX98_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CC84DRAFT_1210559</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441563">
        <property type="protein sequence ID" value="OAF99137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029503.1">
        <property type="nucleotide sequence ID" value="XM_018182297.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BX98"/>
    <dbReference type="STRING" id="1460663.A0A177BX98"/>
    <dbReference type="GeneID" id="28765783"/>
    <dbReference type="InParanoid" id="A0A177BX98"/>
    <dbReference type="OrthoDB" id="4657524at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054508">
        <property type="entry name" value="PIR1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018620">
        <property type="entry name" value="Ubiquitin3-bd_protein_But2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39613">
        <property type="entry name" value="ANCHORED CELL WALL PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G08960)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39613:SF1">
        <property type="entry name" value="ANCHORED CELL WALL PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G08960)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09792">
        <property type="entry name" value="But2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22799">
        <property type="entry name" value="PIR1-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008057489" evidence="2">
        <location>
            <begin position="17"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="Cell wall mannoprotein PIR1-like C-terminal" evidence="4">
        <location>
            <begin position="63"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin 3 binding protein But2 C-terminal" evidence="3">
        <location>
            <begin position="302"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="153"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="232"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF22799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAF99137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="452" mass="46576" checksum="89996DA26AD88165" modified="2016-09-07" version="1">MKYAVIPLVFAVGSSALAIRQSQQCVQLRASGGASGTLGQLSDGQNRVGGGHEAACYCLDGSGGFTDSNGRGCILTPPTTQFQCDAGASPTNGFSINGGSVAYNGNSKFYACPVNDNGEYNVYTQPAPGQEKCVEITLGAGQSCGAGNGGGASQSASQPAQSQPPNASQPAASQPGYSVPPRESQTPKESQPPAPSQPGYSVPPQQPQPPKESQPPPPSQPTPQPPKESQPPKESQPAPSKPAASQPAQSEPAPSQPGYSAPAQSQPAPSKPAPSQPAQSKPPSNDNENGNGCPADLNGEYQYPHLIVPVSASQPSNAPGTSYNGKANGDVCSVFNFDIPKSYSAKSCSLIFLFPEQMDLETSSYTISGSGGLEFSKCETNANNKTSWDNKGTCTAVKTVENVTPGNSYTIVSESCPAGETVTFQMCATGGLSLDYFQDYNPSPIGAYVREC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BXB3</accession>
    <name>A0A177BXB3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1169470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441562">
        <property type="protein sequence ID" value="OAF99341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029707.1">
        <property type="nucleotide sequence ID" value="XM_018179667.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BXB3"/>
    <dbReference type="GeneID" id="28763153"/>
    <dbReference type="InParanoid" id="A0A177BXB3"/>
    <dbReference type="OrthoDB" id="10351364at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008057417" evidence="1">
        <location>
            <begin position="24"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAF99341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="121" mass="13276" checksum="07C9E6B56BCFA686" modified="2016-09-07" version="1">MVATFAYLLTILIALIQFTAVSADFDLYQVSGSSPVHHRVRSVDITAPGPGLLIPPFDYGWQIFDWDAEPTCDQLLQAPFYQNKKDLSHGRVGIRCVGKCGIVDVSLATQNTPFPLNANLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BXD3</accession>
    <name>A0A177BXD3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF1996 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1232788</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441562">
        <property type="protein sequence ID" value="OAF99361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029727.1">
        <property type="nucleotide sequence ID" value="XM_018183773.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BXD3"/>
    <dbReference type="STRING" id="1460663.A0A177BXD3"/>
    <dbReference type="GeneID" id="28767259"/>
    <dbReference type="InParanoid" id="A0A177BXD3"/>
    <dbReference type="OrthoDB" id="74764at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018535">
        <property type="entry name" value="DUF1996"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43662">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43662:SF6">
        <property type="entry name" value="DUF1996 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09362">
        <property type="entry name" value="DUF1996"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008057421" description="DUF1996 domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1996" evidence="2">
        <location>
            <begin position="43"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAF99361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="364" mass="39517" checksum="803D6582D5AF03BF" modified="2016-09-07" version="1">MIFSTLLFAASAAALPKALEPRQGGQNTMLRFGCSQVIIDRIDPLVNPGLAPSPHMHQVVGGNSFNTTMQSTDIAKISTCTTCGYSEDFSNYWTANLYFKAKNGTYKRVPQIPNRDLFNDKYTGKTKGGFVVYYVSPGKGKVTAFKPGFRMLVGDANNRVSKNLKSQTCFRCYTGPNFAGDNAAPCQDAKLDTEGLPKAACPGGIRSNILYPTCWDGKNLDSPDHKSHVAYPKAGPQVFTGSSVGGDCPSTHPVKIPQIMLEIVWDTRQFNNKADWPTDGSQPFVLSTGDTTGFGQHGDYVFGWKDDSLQKAMDDAKGCMGANCGSLKTQQPDDGNACKVPRRVNEDADGWLTELPGMEMPMAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BYB1</accession>
    <name>A0A177BYB1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Conidiation-specific protein 10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1103828</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441561">
        <property type="protein sequence ID" value="OAF99681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030047.1">
        <property type="nucleotide sequence ID" value="XM_018175033.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BYB1"/>
    <dbReference type="STRING" id="1460663.A0A177BYB1"/>
    <dbReference type="GeneID" id="28758519"/>
    <dbReference type="InParanoid" id="A0A177BYB1"/>
    <dbReference type="OrthoDB" id="2137750at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019626">
        <property type="entry name" value="Stress-induced_KGG_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052590">
        <property type="entry name" value="Stress/Virulence-Domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36569">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36569:SF5">
        <property type="entry name" value="CONIDIATION-SPECIFIC PROTEIN 10 (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10685">
        <property type="entry name" value="KGG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAF99681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="102" mass="10671" checksum="0D05AFDA23F9BAA4" modified="2016-09-07" version="1">MADSNPANFANLPKDELREIAAKGGHASHGSNSQAEDHPDRNPDGTFTKGSELAKELGAKGGHVAHEHAVEKEARNPDGTFKAGSKLAQELGEKGGHAAHEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C020</accession>
    <name>A0A177C020_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1168183</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441558">
        <property type="protein sequence ID" value="OAG00983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031348.1">
        <property type="nucleotide sequence ID" value="XM_018179335.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C020"/>
    <dbReference type="STRING" id="1460663.A0A177C020"/>
    <dbReference type="GeneID" id="28762821"/>
    <dbReference type="InParanoid" id="A0A177C020"/>
    <dbReference type="OrthoDB" id="3926760at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="339"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="339"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG00983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="404" mass="43626" checksum="2C19AF88A1D9B6A1" modified="2016-09-07" version="1">MPAPLAKGPGSSARPASPVYHARHAPQRPNHPFSTGLIIAASVLVAAGIAIYESPQVRQWVDQSRRKIAIALHSLGDEMQPRRPSESSDDFNERKRRQREEIIRRNRNELIRRAREEGIAVDLDELARIGEETVELTERRQRRRTNASQKSFDDLVGSDGMLKKDTSTTQIATGNDASGSTLRHRGAAGFAAGSVAAAAVANPFSDDHVLFDRDEEEAHSPKPFIYTEPDTRESSATVEAEPVASPITAQLIDLTPESVYQNPEDPQTASIPASEAGDQAAQSFYSFTSEAHETHSDDEAEVISTGTLTPRSDRSGFLTGASVVGSQADDIGILSMQNDSDHDARSDTFSESGFTEAGFSEAGFSEVGENRGIMTPSSWTDVGSDDESEWGGPAHGGHVSQVQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2023-06-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C041</accession>
    <name>A0A177C041_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_245659</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441558">
        <property type="protein sequence ID" value="OAG00776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031141.1">
        <property type="nucleotide sequence ID" value="XM_018185654.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C041"/>
    <dbReference type="GeneID" id="28769140"/>
    <dbReference type="InParanoid" id="A0A177C041"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG00776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="157" mass="17051" checksum="F6ADCD2578B069B3" modified="2016-09-07" version="1">MCSAAGCHLHQQPDAPCNASNLEPIQTVGPSSGTNSTAVLISETTSDTRLVLRWRWYQLFRSKSISNFPLAFSDKAGFSRVNGASQWKLQTTQEKSNRRCEGAASWAAIVSSSQRGLDIYVNASTGSCIESFGWFCRSQSLVESTGGPHSELGQSRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C044</accession>
    <name>A0A177C044_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_316306</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441559">
        <property type="protein sequence ID" value="OAG00611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030976.1">
        <property type="nucleotide sequence ID" value="XM_018185836.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C044"/>
    <dbReference type="GeneID" id="28769322"/>
    <dbReference type="InParanoid" id="A0A177C044"/>
    <dbReference type="OrthoDB" id="3800844at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="442"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="560"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="600"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="211"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="321"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="226"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="351"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG00611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="628" mass="70761" checksum="52D8800E26826FBD" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2023-06-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C0E4</accession>
    <name>A0A177C0E4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_362047</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441560">
        <property type="protein sequence ID" value="OAG00177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030542.1">
        <property type="nucleotide sequence ID" value="XM_018185912.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C0E4"/>
    <dbReference type="GeneID" id="28769398"/>
    <dbReference type="InParanoid" id="A0A177C0E4"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG00177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="67" mass="7522" checksum="B05CEBC63AC941F3" modified="2016-09-07" version="1">MFKNAATMLEYKSHLLGLVANMPGQDTLTYSTLIEKYGSQQTLLWVGNSKLIMDFANRPELERGATI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C0P7</accession>
    <name>A0A177C0P7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1154390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441558">
        <property type="protein sequence ID" value="OAG00986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031351.1">
        <property type="nucleotide sequence ID" value="XM_018176885.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C0P7"/>
    <dbReference type="STRING" id="1460663.A0A177C0P7"/>
    <dbReference type="GeneID" id="28760371"/>
    <dbReference type="InParanoid" id="A0A177C0P7"/>
    <dbReference type="OrthoDB" id="449487at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05188">
        <property type="entry name" value="MDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000481">
        <property type="entry name" value="Alcohol dehydrogenase, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052711">
        <property type="entry name" value="Zinc_ADH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45033">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45033:SF3">
        <property type="entry name" value="DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G13270)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="1">
        <location>
            <begin position="12"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG00986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="361" mass="38334" checksum="E1144BECAA5A3676" modified="2016-09-07" version="1">MPSAIAIKQVPGKPGQVYYPLEKITIPEPRPSENEAVISLTAAALNHRDLFIRQHLYPGTAFGVPLLADGVGVVTRTGSSAAAQKWNGKRVLLNPGTGWKDSPDGPEHPKGYAIMGGTKSNPAGTLADVATLDSGELEACPEHLSDEEAAALPLTGLTAWRAFFVKSGNALPGRNIFVTGIGGGVALMVLLFGVAQGCNVYVSSGDQKKIDKAIKLGAKGGVNYKEEGWEKKLRASLPKDRPYFDAIVDGAGGDIVAKGTKLLKAGGVISIYGMTVSPKMNFLMTAVLSNIEVRGSTMGSRKEFAEMVQFVREKKIRPIVSRSVHGMDIGQLDDLFEDMKNATQFGKLVVTLGEKGKASKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C0S0</accession>
    <name>A0A177C0S0_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Complex 1 LYR protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CC84DRAFT_1230203</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the complex I LYR family. SDHAF1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV441559">
        <property type="protein sequence ID" value="OAG00307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030672.1">
        <property type="nucleotide sequence ID" value="XM_018183690.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C0S0"/>
    <dbReference type="FunCoup" id="A0A177C0S0">
        <property type="interactions" value="83"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177C0S0"/>
    <dbReference type="GeneID" id="28767176"/>
    <dbReference type="InParanoid" id="A0A177C0S0"/>
    <dbReference type="OrthoDB" id="273010at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034553">
        <property type="term" value="P:mitochondrial respiratory chain complex II assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20268">
        <property type="entry name" value="Complex1_LYR_SDHAF1_LYRM8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008011">
        <property type="entry name" value="Complex1_LYR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045295">
        <property type="entry name" value="Complex1_LYR_SDHAF1_LYRM8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13675">
        <property type="entry name" value="LYR MOTIF-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13675:SF1">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE ASSEMBLY FACTOR 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05347">
        <property type="entry name" value="Complex1_LYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Complex 1 LYR protein" evidence="5">
        <location>
            <begin position="9"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAG00307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="79" mass="9270" checksum="9EC3B433038DC02A" modified="2016-09-07" version="1">MARLSGLQRDVLSLYRQCLRAARAKPATNRGHFQALARNEFHKHRAVDKKDFSAIEYLLRRGRRQLEMYEEAGVRDVKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C199</accession>
    <name>A0A177C199_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CC84DRAFT_1190625</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441559">
        <property type="protein sequence ID" value="OAG00578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030943.1">
        <property type="nucleotide sequence ID" value="XM_018181125.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C199"/>
    <dbReference type="FunCoup" id="A0A177C199">
        <property type="interactions" value="1271"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177C199"/>
    <dbReference type="GeneID" id="28764611"/>
    <dbReference type="InParanoid" id="A0A177C199"/>
    <dbReference type="OrthoDB" id="4236860at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051430">
        <property type="entry name" value="Fungal_TF_Env_Response"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31944">
        <property type="entry name" value="HEME-RESPONSIVE ZINC FINGER TRANSCRIPTION FACTOR HAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31944:SF130">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTO (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="29"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="70"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="739"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="739"/>
            <end position="750"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAG00578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="826" mass="92215" checksum="DC85D8FB076F1AA9" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C1K5</accession>
    <name>A0A177C1K5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">26S proteasome-like protein regulatory subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CC84DRAFT_1127542</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M67A family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441557">
        <property type="protein sequence ID" value="OAG01664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032029.1">
        <property type="nucleotide sequence ID" value="XM_018175777.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C1K5"/>
    <dbReference type="FunCoup" id="A0A177C1K5">
        <property type="interactions" value="1058"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177C1K5"/>
    <dbReference type="GeneID" id="28759263"/>
    <dbReference type="InParanoid" id="A0A177C1K5"/>
    <dbReference type="OrthoDB" id="10256771at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034515">
        <property type="term" value="C:proteasome storage granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd08062">
        <property type="entry name" value="MPN_RPN7_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000004">
        <property type="entry name" value="26S proteasome regulatory subunit rpn-8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024969">
        <property type="entry name" value="EIF3F/CSN6-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033858">
        <property type="entry name" value="MPN_RPN7_8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10540:SF7">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10540">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13012">
        <property type="entry name" value="MitMem_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0647">Proteasome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MPN" evidence="5">
        <location>
            <begin position="16"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="312"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="316"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAG01664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="359" mass="39450" checksum="387AEBA257F5C870" modified="2016-09-07" version="1">MPATTAETLSLVTRNVSVAPLVLLSAADHYGRQAKGTRKRVVGVLLGQNDGKNVRVSNSFAVPFEEDEKDPSVWFLDHNYVESMNDMFKKVNAREKLIGWYHTGPKLRASDLEINELFKRYTPNPLLVIIDVQPKEVGVPTDAYFAVEEIKDDGTTTSKTFVHTPSMIEAEEAEEIGVEHLLRDIRDVAVGTLSTRITSQLQSLQGLHLRLRDIGQYLQKVLDGDLPVNHAILGNLQDVFNLLPNLSTPKPSPVKGATNGVGPASGAAGAADNSELARAMSIKTNDQLMAIYLSSLIRAITAFHDLIENKIQNKQQAEDKETKKDEGKEGDKDKKANGVNGDTKEGDKEKSKEPEKKKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C1S0</accession>
    <name>A0A177C1S0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CC84DRAFT_1168734</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441559">
        <property type="protein sequence ID" value="OAG00677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031042.1">
        <property type="nucleotide sequence ID" value="XM_018179469.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C1S0"/>
    <dbReference type="STRING" id="1460663.A0A177C1S0"/>
    <dbReference type="GeneID" id="28762955"/>
    <dbReference type="InParanoid" id="A0A177C1S0"/>
    <dbReference type="OrthoDB" id="3945418at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11062">
        <property type="entry name" value="CYP58-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF157">
        <property type="entry name" value="N-ACETYLTRYPTOPHAN 6-HYDROXYLASE IVOC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7 8" id="KW-0408">Iron</keyword>
    <keyword evidence="3 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="385"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="392"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="462"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAG00677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="523" mass="58285" checksum="0F7440760CA1524E" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C1V7</accession>
    <name>A0A177C1V7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1228490</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441557">
        <property type="protein sequence ID" value="OAG01425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031790.1">
        <property type="nucleotide sequence ID" value="XM_018183641.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C1V7"/>
    <dbReference type="STRING" id="1460663.A0A177C1V7"/>
    <dbReference type="GeneID" id="28767127"/>
    <dbReference type="InParanoid" id="A0A177C1V7"/>
    <dbReference type="OrthoDB" id="6105938at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38846">
        <property type="entry name" value="C3H1-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38846:SF1">
        <property type="entry name" value="C3H1-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG01425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="99" mass="11648" checksum="DF8903E8E955F0F2" modified="2016-09-07" version="1" fragment="single">FDETYGTNYKDLEAWQHFCADVGIEPIPESIKKCKKALKKVFINIFDFIAVQKRLKPAPPRRFRAVHELAHYSIESIKIYPLELAKKETFHRALLQVLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C2I9</accession>
    <name>A0A177C2I9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Diaminopimelate epimerase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1199088</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441558">
        <property type="protein sequence ID" value="OAG01028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031393.1">
        <property type="nucleotide sequence ID" value="XM_018181600.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C2I9"/>
    <dbReference type="FunCoup" id="A0A177C2I9">
        <property type="interactions" value="146"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177C2I9"/>
    <dbReference type="GeneID" id="28765086"/>
    <dbReference type="InParanoid" id="A0A177C2I9"/>
    <dbReference type="OrthoDB" id="412383at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.310.10">
        <property type="entry name" value="Diaminopimelate Epimerase, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003719">
        <property type="entry name" value="Phenazine_PhzF-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00654">
        <property type="entry name" value="PhzF_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13774:SF32">
        <property type="entry name" value="ANTISENSE-ENHANCING SEQUENCE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13774">
        <property type="entry name" value="PHENAZINE BIOSYNTHESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02567">
        <property type="entry name" value="PhzC-PhzF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016184">
        <property type="entry name" value="PhzC_PhzF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54506">
        <property type="entry name" value="Diaminopimelate epimerase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="1">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR016184-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG01028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="311" mass="34237" checksum="FE775E8ECD05B3B7" modified="2016-09-07" version="1">MNSNFEKLDYSIVDVFTDKRYEGNPLAIVRLPALSKVTQEQKQNIAREFNLSETTFLHEPTSDGSCEWTVDIFMVNAELPFAGHPTIGTACLALSEVAERSNSQGIIQGTFNLKAGPVQLQYDTTKKTAKAAIPHDVHVHDRTWSRDELLAQQPALAEFVEDNVKIPIVSIVKGMTFILIELKSLDALEMVKLTTKVNVDKLDQGWDKTFVGTYYYVQTSKSENVRQLRTRMIEGSLEDPATGSAASDLAAYLSLQHGKPGQTLEFSITQGVEMGRRSEIAVSVEMGAEKGINTITLGGGAIPVMEGRLQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C2J3</accession>
    <name>A0A177C2J3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1127863</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioredoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441557">
        <property type="protein sequence ID" value="OAG01863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032228.1">
        <property type="nucleotide sequence ID" value="XM_018175784.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C2J3"/>
    <dbReference type="STRING" id="1460663.A0A177C2J3"/>
    <dbReference type="GeneID" id="28759270"/>
    <dbReference type="InParanoid" id="A0A177C2J3"/>
    <dbReference type="OrthoDB" id="78947at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047134">
        <property type="term" value="F:protein-disulfide reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000304">
        <property type="entry name" value="Unplaced genomic scaffold supercont1.12, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045108">
        <property type="entry name" value="TXNDC17-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010357">
        <property type="entry name" value="TXNDC17_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12452">
        <property type="entry name" value="42-9-9 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12452:SF0">
        <property type="entry name" value="THIOREDOXIN DOMAIN-CONTAINING PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06110">
        <property type="entry name" value="TXD17-like_Trx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="2">
        <location>
            <begin position="20"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG01863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="134" mass="15106" checksum="73C7C67731073BDA" modified="2016-09-07" version="1">MPIQDPFQLPKSAQDLPLANDTDDTYFLFFISSISPETKQPWCPDVRAALPVVGAAFSFENAPEVGFVHVGQKPEWKDVSNLHRTKWNVNAVPTLVRYQRAGAEVKETGRLVEDELLDQEKLKELVDGKRKSVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C3M7</accession>
    <name>A0A177C3M7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GDSL lipase/acylhydrolase family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1208616</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441557">
        <property type="protein sequence ID" value="OAG01482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031847.1">
        <property type="nucleotide sequence ID" value="XM_018182171.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C3M7"/>
    <dbReference type="STRING" id="1460663.A0A177C3M7"/>
    <dbReference type="GeneID" id="28765657"/>
    <dbReference type="InParanoid" id="A0A177C3M7"/>
    <dbReference type="OrthoDB" id="1600564at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01846">
        <property type="entry name" value="fatty_acyltransferase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001087">
        <property type="entry name" value="GDSL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051058">
        <property type="entry name" value="GDSL_Est/Lipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45648">
        <property type="entry name" value="GDSL LIPASE/ACYLHYDROLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_4G14700)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45648:SF22">
        <property type="entry name" value="GDSL LIPASE_ACYLHYDROLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_4G14700)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00657">
        <property type="entry name" value="Lipase_GDSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008057662" description="GDSL lipase/acylhydrolase family protein" evidence="2">
        <location>
            <begin position="17"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG01482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="350" mass="38452" checksum="92644259707D2FA8" modified="2016-09-07" version="1">MRWFTFSSIALGAASAEYITNSWQTQDFKTLVTFGDSYTDENRLGYFINHNGSAPPVGVDLGVSYKASTGGLVWPRYASIYANSTLYNYAVSGAVCSNQITPRTFAAINAPFPDILGYELPAYLADSKYVSPNGTAFFTGTPDTTVYAIWIGTNDVGNNAFLTDSQVAGKVLTDYVDCVYDVVDGLYASGARYFVLLNLAPLNLVPQYATPAQGGLNSSQFFTDKQNFSGGNITEISYRMLETVDTVNGIYQYRTPFETRVNNTWPGANIANFDVNALITDMYAHPAEYLNGTAPLNTTGYVIGAGNISRSDRDSFLWYDELHPSEQLDRVVAREFVGVLGGESKWAKYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C5K0</accession>
    <name>A0A177C5K0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1124575</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG02706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033071.1">
        <property type="nucleotide sequence ID" value="XM_018175697.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C5K0"/>
    <dbReference type="STRING" id="1460663.A0A177C5K0"/>
    <dbReference type="GeneID" id="28759183"/>
    <dbReference type="InParanoid" id="A0A177C5K0"/>
    <dbReference type="OrthoDB" id="542013at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF152">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG02706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="322" mass="35798" checksum="CDB3639AC9B612AB" modified="2016-09-07" version="1">MEYKRTVLITGGTMNMGYHAALTIARQHPEYLVVISSRSDPNNAASTINNTLSQNNVIFLPLDLSSSSNVRTYAKTWASRSFPPIQALLLNAALQFPGDLTLTDEGIEKTFAITHVGHALLFHLLCPFLAPKARVIITASGVHDPALKTGMPKPIYTSAENLAHPPAEIAKGDGRLHYVNAKLSNIMWTYALHRRLEQSGNEKGISVLAMDPGLMPGSGLAREYPPLMRWLWNNLLPRITPVLRVAFRTDNVHTTKESGENLARLGVAKDVEGLSGKYYEGKKQRDSSVESYEVKKQDDLWEWTVKYAAKDPEELARFNKFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C607</accession>
    <name>A0A177C607_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1179068</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441556">
        <property type="protein sequence ID" value="OAG02120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032485.1">
        <property type="nucleotide sequence ID" value="XM_018180384.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C607"/>
    <dbReference type="GeneID" id="28763870"/>
    <dbReference type="InParanoid" id="A0A177C607"/>
    <dbReference type="OrthoDB" id="3799476at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG02120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="367" mass="42755" checksum="1E49F90ECDE8D75E" modified="2016-09-07" version="1">MLAQVLRYRKDVRPSGGGVACTTPQSTHTAIDIARPHEYCTMPRSPSPYGGQRRRRTEVSPPDYMDEFGGRHHQPAHSRGRGPRYDDERTADRGGMRGAFDAVKNFISESTEDRDRPRRAKSHREPRPRPYPPSDSDSGSPPPRRRRDSPPPRAKARAPEAPPAYADDYDDPNRPQRRRRPRENDYYSDSRHDRPRRDAYDERPRRRDDYDEPPRRRDRDDRNDDRPRRRDPYDERYDDRPRRRDTGYDDRPRRDRDPRYDDRLLRDPRDDRVRSGRGGRKDVPDWQRQAKDMFFTHAMPVIKKEGPKLIAKYAGDFLKQVSENQDCLAATTFAASNPPDISIAVPSQSATALCSLTTHSERPISSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C6F6</accession>
    <name>A0A177C6F6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1166771</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG02986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033351.1">
        <property type="nucleotide sequence ID" value="XM_018179045.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C6F6"/>
    <dbReference type="GeneID" id="28762531"/>
    <dbReference type="InParanoid" id="A0A177C6F6"/>
    <dbReference type="OrthoDB" id="113620at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG02986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="93" mass="10565" checksum="E4C441E6EAFA8074" modified="2016-09-07" version="1">MSTFSSVLRPTLFSTLCNAIFLGGATYHLSTRIDRNLEEQEARLDEIEGTLRGHIGLIEDALDRIEGKANRGRQEELYGKRGRDEKEQKGKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C6W5</accession>
    <name>A0A177C6W5_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 4">Vacuolar fusion protein MON1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CC84DRAFT_901852</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">In complex with CCZ1, is required for multiple vacuole delivery pathways including the cytoplasm to vacuole transport (Cvt), autophagy, pexophagy and endocytosis. The MON1-CCZ1 complex acts at the fusion of vesicles with the vacuole, through its regulation of the SNARE complex during the coordinated priming and docking stages of fusion, and particularly at the stage of tethering/docking.</text>
    </comment>
    <comment type="function">
        <text evidence="4">Required for multiple vacuole delivery pathways including the cytoplasm to vacuole transport (Cvt), autophagy, pexophagy and endocytosis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Endosome</location>
            <location evidence="4">Multivesicular body membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 4">Prevacuolar compartment membrane</location>
            <topology evidence="1 4">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Vacuole membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the MON1/SAND family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG02612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032977.1">
        <property type="nucleotide sequence ID" value="XM_018187847.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C6W5"/>
    <dbReference type="FunCoup" id="A0A177C6W5">
        <property type="interactions" value="537"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177C6W5"/>
    <dbReference type="GeneID" id="28771333"/>
    <dbReference type="InParanoid" id="A0A177C6W5"/>
    <dbReference type="OrthoDB" id="272411at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035658">
        <property type="term" value="C:Mon1-Ccz1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032585">
        <property type="term" value="C:multivesicular body membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043972">
        <property type="entry name" value="FUZ/MON1/HPS1_longin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043971">
        <property type="entry name" value="FUZ/MON1/HPS1_longin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043970">
        <property type="entry name" value="FUZ/MON1/HPS1_longin_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004353">
        <property type="entry name" value="Mon1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13027">
        <property type="entry name" value="SAND PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13027:SF7">
        <property type="entry name" value="VACUOLAR FUSION PROTEIN MON1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19036">
        <property type="entry name" value="Fuz_longin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19037">
        <property type="entry name" value="Fuz_longin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19038">
        <property type="entry name" value="Fuz_longin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01546">
        <property type="entry name" value="YEAST73DUF"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0072">Autophagy</keyword>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <keyword evidence="4" id="KW-0926">Vacuole</keyword>
    <feature type="domain" description="FUZ/MON1/HPS1 first Longin" evidence="6">
        <location>
            <begin position="244"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="domain" description="FUZ/MON1/HPS1 second Longin" evidence="7">
        <location>
            <begin position="406"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="domain" description="FUZ/MON1/HPS1 third Longin" evidence="8">
        <location>
            <begin position="554"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="10"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="44"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="111"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="122"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00043892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF19036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF19037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF19038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAG02612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="664" mass="72452" checksum="AF3AA73E175B1E68" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C737</accession>
    <name>A0A177C737_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="19">White collar</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CC84DRAFT_1097020</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG02588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032953.1">
        <property type="nucleotide sequence ID" value="XM_018174696.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C737"/>
    <dbReference type="STRING" id="1460663.A0A177C737"/>
    <dbReference type="GeneID" id="28758182"/>
    <dbReference type="InParanoid" id="A0A177C737"/>
    <dbReference type="OrthoDB" id="447251at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009881">
        <property type="term" value="F:photoreceptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="CDD" id="cd00202">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.50.10:FF:000065">
        <property type="entry name" value="GATA transcription factor LreA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.20:FF:000064">
        <property type="entry name" value="Vivid PAS protein VVD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.20:FF:000063">
        <property type="entry name" value="White collar 1 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.20:FF:000087">
        <property type="entry name" value="White collar 1 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47429:SF7">
        <property type="entry name" value="GATA-FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47429">
        <property type="entry name" value="PROTEIN TWIN LOV 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00320">
        <property type="entry name" value="GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
        <property type="entry name" value="PAS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13426">
        <property type="entry name" value="PAS_9"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00344">
        <property type="entry name" value="GATA_ZN_FINGER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12" id="KW-0010">Activator</keyword>
    <keyword evidence="9" id="KW-0157">Chromophore</keyword>
    <keyword evidence="11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0288">FMN</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0600">Photoreceptor protein</keyword>
    <keyword evidence="14" id="KW-0675">Receptor</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="13" id="KW-0804">Transcription</keyword>
    <keyword evidence="10" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 15" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PAS" evidence="17">
        <location>
            <begin position="387"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="17">
        <location>
            <begin position="562"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="17">
        <location>
            <begin position="692"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="domain" description="GATA-type" evidence="18">
        <location>
            <begin position="927"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="205"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="798"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="961"/>
            <end position="1060"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="219"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="261"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="272"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="295"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="815"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="982"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="995"/>
            <end position="1009"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="1051"/>
            <end position="1060"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="OAG02588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="1060" mass="116229" checksum="ECD789EBE1C91667" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C793</accession>
    <name>A0A177C793_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S26</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CC84DRAFT_1166409</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS26 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG02570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032935.1">
        <property type="nucleotide sequence ID" value="XM_018178957.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C793"/>
    <dbReference type="FunCoup" id="A0A177C793">
        <property type="interactions" value="753"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177C793"/>
    <dbReference type="GeneID" id="28762443"/>
    <dbReference type="InParanoid" id="A0A177C793"/>
    <dbReference type="OrthoDB" id="10262653at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1740.20:FF:000001">
        <property type="entry name" value="40S ribosomal protein S26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1740.20">
        <property type="entry name" value="Ribosomal protein S26e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000892">
        <property type="entry name" value="Ribosomal_eS26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047864">
        <property type="entry name" value="Ribosomal_eS26_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038551">
        <property type="entry name" value="Ribosomal_eS26_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12538">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12538:SF0">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01283">
        <property type="entry name" value="Ribosomal_S26e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00733">
        <property type="entry name" value="RIBOSOMAL_S26E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="87"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="111"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAG02570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="122" mass="13854" checksum="F4AC01B22A851CF7" modified="2016-09-07" version="1">MVKKRASNGRNKKGRGHVKPIRCSNCSRCTPKDKAIKRFTIRNMVESAAIRDISDASVFPEYTVPKMYLKLQYCVSCAIHGKIVRVRSREGRRNRAPPPRVRYNKDGKKVNPNQAAPKQTTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C840</accession>
    <name>A0A177C840_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">alpha-L-fucosidase</fullName>
            <ecNumber evidence="3">3.2.1.51</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_1097565</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 29 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.51" evidence="3"/>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG03301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033666.1">
        <property type="nucleotide sequence ID" value="XM_018174719.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C840"/>
    <dbReference type="STRING" id="1460663.A0A177C840"/>
    <dbReference type="GeneID" id="28758205"/>
    <dbReference type="InParanoid" id="A0A177C840"/>
    <dbReference type="OrthoDB" id="6039950at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004560">
        <property type="term" value="F:alpha-L-fucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006004">
        <property type="term" value="P:fucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016139">
        <property type="term" value="P:glycoside catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016286">
        <property type="entry name" value="FUC_metazoa-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000933">
        <property type="entry name" value="Glyco_hydro_29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057739">
        <property type="entry name" value="Glyco_hydro_29_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10030">
        <property type="entry name" value="ALPHA-L-FUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10030:SF37">
        <property type="entry name" value="ALPHA-L-FUCOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01120">
        <property type="entry name" value="Alpha_L_fucos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00741">
        <property type="entry name" value="GLHYDRLASE29"/>
    </dbReference>
    <dbReference type="SMART" id="SM00812">
        <property type="entry name" value="Alpha_L_fucos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Glycoside hydrolase family 29 N-terminal" evidence="7">
        <location>
            <begin position="320"/>
            <end position="674"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAG03301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="771" mass="84649" checksum="92F3995AB195BE68" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C8C3</accession>
    <name>A0A177C8C3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_1206771</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG03381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033746.1">
        <property type="nucleotide sequence ID" value="XM_018182057.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C8C3"/>
    <dbReference type="STRING" id="1460663.A0A177C8C3"/>
    <dbReference type="GeneID" id="28765543"/>
    <dbReference type="InParanoid" id="A0A177C8C3"/>
    <dbReference type="OrthoDB" id="416217at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052400">
        <property type="entry name" value="Zn2-C6_fungal_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47657">
        <property type="entry name" value="STEROL REGULATORY ELEMENT-BINDING PROTEIN ECM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47657:SF13">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="51"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAG03381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="405" mass="45745" checksum="8474C0EA3E668164" modified="2016-09-07" version="1">MSDALPTPSEPADSPEGSDGVARRPSPEEGSARGAENKAIKRRAHRKSRFGCKNCKLRRIKCDERKPECLNCRNRQVRCDYLPSSQAAVTTAAPSPAEAVVAPSLFGALNVEDLELMYHWTTSTSATLSSQTSGAIFWRTQVTELALSHHHILHLILSITASHLARFRPQRRDEYVALADHHYATALPVVTAELSHLHQDNCDPVLLSVQLICTFTWARGPQPGEYLAFGEKGRSDWLVMFRGIRTTLETVGYDNFTRSMAPNIRAHAKPLPNVAGTLAYEEPLAELSDYIQYASKPAQLSQNVYAHQVLLECYSNRYGGVDGEYHIVFAWLFRMHEEFLEALQRHQTVPLVIYAHFAVLMNDMESFWYMKGWTTHVLAGIWNILRDEDRVHIRWPVSVVGWIPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C8J1</accession>
    <name>A0A177C8J1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_864782</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG03716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034081.1">
        <property type="nucleotide sequence ID" value="XM_018187694.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C8J1"/>
    <dbReference type="GeneID" id="28771180"/>
    <dbReference type="InParanoid" id="A0A177C8J1"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG03716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="217" mass="24173" checksum="21F1CAFECC116F68" modified="2016-09-07" version="1">MLLPLMPFLHLTAQIRARQRSRNRMVAQQLAANHARRTAADRAHQATLVFARGGQRCVRIVCAVGVEWSSVTGLLVLVLGTWRVARWRWWRLVGGVVVVVTVGLAVGTAVVLESHCQGMALSESITLADRGMVRIVGSSDCRDTGFAADKVGLRRMPVKRIAWGIRLVDTIGLEPRIAGRGRRCRRCIYQPWSCSCARKYSLGRFRESLKLMKPEAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C907</accession>
    <name>A0A177C907_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1207389</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG04234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034599.1">
        <property type="nucleotide sequence ID" value="XM_018182099.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C907"/>
    <dbReference type="GeneID" id="28765585"/>
    <dbReference type="InParanoid" id="A0A177C907"/>
    <dbReference type="OrthoDB" id="10648402at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG04234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="180" mass="19654" checksum="3BE6290CD06D4BA0" modified="2016-09-07" version="1">MSIHRSSQSTCSFPSLTQLGFREPIIQALPQTVITPYPRRVAYERRRGGVRGSVDARTLLAIATGSGYLDFLPTGVMLIATTGGAHPDIEQEKCIARMTETDLRAAPRLTTNNENRQSGGHASHSHGWMTSKIKAYIHKASTIGHHGKFIRPSPAGNLKQLTTPSPWVIIARPSAFGQRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C9I6</accession>
    <name>A0A177C9I6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="15">DNase I-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CC84DRAFT_1122663</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the neutral sphingomyelinase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG03438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033803.1">
        <property type="nucleotide sequence ID" value="XM_018175637.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C9I6"/>
    <dbReference type="FunCoup" id="A0A177C9I6">
        <property type="interactions" value="75"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177C9I6"/>
    <dbReference type="GeneID" id="28759123"/>
    <dbReference type="InParanoid" id="A0A177C9I6"/>
    <dbReference type="OrthoDB" id="387657at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052714">
        <property type="term" value="F:mannosyl-inositol phosphorylceramide phospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004767">
        <property type="term" value="F:sphingomyelin phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006665">
        <property type="term" value="P:sphingolipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.10.10:FF:000059">
        <property type="entry name" value="Inositol phosphosphingolipids phospholipase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038772">
        <property type="entry name" value="Sph/SMPD2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16320:SF24">
        <property type="entry name" value="PHOSPHODIESTERASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16320">
        <property type="entry name" value="SPHINGOMYELINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="396"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="422"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="14">
        <location>
            <begin position="24"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OAG03438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="481" mass="54283" checksum="7CB0BDCF19403DAA" modified="2016-09-07" version="1">MHERPESPFMIEETSRPPSSLRILSLNCWGLKYIAKLRKERLTEIANQIAAADPPPDIVGLQECWTQRDYDVIREKTKHFLPYGKFYFSGIFGGGLVILSRWPIEESSMTQYPLNGRPAAFYRGDWFVGKGVAYARIRMGPTRRDIAEVFCTHLHAPYETEPHDSYICHRTAQAWEIAKLMRGAAERGHLVIGLGDFNMTPLSLAHRIIETHSRARDVWRVLYPNSSLGAAKDKVEQMRNVPMPNAEYNLTKNGATCDSALNTWRWNKAHSQRLAKGENVQIEATVDDPNAKRLDYIFFSSGSHHDATNGHPSAEWTLKEANVGMTARHPTLYCSLSDHFSVEATLVRNLEEPLSTTSNGPYALPETYLPIGIYDEILTTIAKYANRERIQRRLRLGHFGFQLSLTIGCLIGVWWVPHNYVAFILMLISSLSLSVGVIDGLMGGLFVSSELRALKEFEWEVSNTKERALARSAKEGLSATS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C9L2</accession>
    <name>A0A177C9L2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_867570</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG03811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034176.1">
        <property type="nucleotide sequence ID" value="XM_018187721.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C9L2"/>
    <dbReference type="GeneID" id="28771207"/>
    <dbReference type="InParanoid" id="A0A177C9L2"/>
    <dbReference type="OrthoDB" id="3690919at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG03811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="339" mass="37487" checksum="2FBA32869663CA5F" modified="2016-09-07" version="1">MNEMEAAKYEHLDASSTLQLDTRDNYTEVQKHPTGYPYHAYEAAKAEPCAVHADGYILPIHMLTCGHLVAIDSPLTGSSDNRCGLNCLHVAHWIKQQTDNATAQNADLRADQSCEQVLTSSTTLKSTTDPVLPAITQHQSRDNIYCEICHGLPAGSYFVVPRDVRRALAFTRPVIEHFCGLASEEIVNQLCRPFYNPDKLGYDWKLTHILRCGHQVWAQPARPCAANCSDTPECKSRIFPGNNQQGDVIFCYECVYRAEIVYARYAQAGRDLTRRSESQTGLQGVLVPGNAQHVPQPQVVPTYEVADPISGSYLEYRSADGFPFDPVSEEGSSMSSSGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C9R5</accession>
    <name>A0A177C9R5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Six-hairpin glycosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1165748</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG03518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033883.1">
        <property type="nucleotide sequence ID" value="XM_018178789.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C9R5"/>
    <dbReference type="GeneID" id="28762275"/>
    <dbReference type="InParanoid" id="A0A177C9R5"/>
    <dbReference type="OrthoDB" id="406733at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011613">
        <property type="entry name" value="GH15-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31616:SF0">
        <property type="entry name" value="GLUCAN 1,4-ALPHA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31616">
        <property type="entry name" value="TREHALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00723">
        <property type="entry name" value="Glyco_hydro_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GH15-like" evidence="1">
        <location>
            <begin position="1"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG03518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="300" mass="34049" checksum="FE8B8252D2E78E3A" modified="2016-09-07" version="1">MYTIRGETDIPEIELAHLEGYRASKPVRIGNGAASHMQLDIYGELMDGIYLSNRLGKPISYDQWLSVREITDYVCQIWQEKDMSIWEVRNAKQNFVYSKIMLWVAVDRALRLADKRCFPCPQRQEWYRVRDAIMEEVMEKGYNKELGAFIQSYEANEMLDSAVLIAPLVFFVSPNDPRFLGTLDHILKAPEKGGLTSTGLVYRYNSAKSDDGVGGREGAFSMCTFWLVEALTRAAAYESKYLPQAVTMFENILSFGNHLRMFSEEIARSGEQLGNTPQAFSHLALISAAFNLDRTLGSPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CA77</accession>
    <name>A0A177CA77_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Retrotransposon Copia-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1197556</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG04031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034396.1">
        <property type="nucleotide sequence ID" value="XM_018181529.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CA77"/>
    <dbReference type="STRING" id="1460663.A0A177CA77"/>
    <dbReference type="GeneID" id="28765015"/>
    <dbReference type="InParanoid" id="A0A177CA77"/>
    <dbReference type="OrthoDB" id="3883943at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="318"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="333"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG04031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="351" mass="39610" checksum="F1BE1479E9B4482F" modified="2016-09-07" version="1">MASLSPRLPGVMLLRAEATGPEYARWKREIKSAFTAKGTWGHCDGSVPMPMPGAGPNFFSPVTQPDMQTTLLEDRKAWVKKDREVKLDIFLSVSDDIKLEVFEVGPPLPPMSMNAKEMLEALDEHYDGFKFEDYHHVFCHFLNLHIDQYTNIEDFNAEFQATLEDLLDHGHPLSNMQACSAYFSKLRCTQNPWVAKQIKIWDSRDKEPQLAQLMQQSPPWSIIRPLTMSTKAASTHASVPASIPEEPAMDTPPHSDSEDTPSERSVSTISSSKPSHSRDSSNATQRSQEITIHASYEDLTELHLQAFPESRQSNSIRTRQRGNRLPPHRRSSRATPRPNSRPTSPPRTSPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CAG5</accession>
    <name>A0A177CAG5_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pro-apoptotic serine protease NMA111</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Pro-apoptotic serine protease nma111</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CC84DRAFT_1219041</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Nuclear serine protease which mediates apoptosis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S1C family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG03768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034133.1">
        <property type="nucleotide sequence ID" value="XM_018183050.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CAG5"/>
    <dbReference type="FunCoup" id="A0A177CAG5">
        <property type="interactions" value="136"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CAG5"/>
    <dbReference type="GeneID" id="28766536"/>
    <dbReference type="InParanoid" id="A0A177CAG5"/>
    <dbReference type="OrthoDB" id="4217619at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034605">
        <property type="term" value="P:cellular response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120174">
        <property type="term" value="P:stress-induced homeostatically regulated protein degradation pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd06786">
        <property type="entry name" value="cpPDZ1_ScNma111-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06719">
        <property type="entry name" value="PDZ2-4_Nma111p-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.120">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025926">
        <property type="entry name" value="PDZ-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001940">
        <property type="entry name" value="Peptidase_S1C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46366">
        <property type="entry name" value="PRO-APOPTOTIC SERINE PROTEASE NMA111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46366:SF8">
        <property type="entry name" value="PRO-APOPTOTIC SERINE PROTEASE NMA111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12812">
        <property type="entry name" value="PDZ_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13365">
        <property type="entry name" value="Trypsin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00834">
        <property type="entry name" value="PROTEASES2C"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PDZ" evidence="8">
        <location>
            <begin position="474"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="8">
        <location>
            <begin position="1047"/>
            <end position="1128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="76"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="165"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="168"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="191"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAG03768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="1262" mass="139240" checksum="B9F6A30B65CE312C" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CAH2</accession>
    <name>A0A177CAH2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Di-copper centre-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CC84DRAFT_1094236</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG04575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034940.1">
        <property type="nucleotide sequence ID" value="XM_018174553.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CAH2"/>
    <dbReference type="STRING" id="1460663.A0A177CAH2"/>
    <dbReference type="GeneID" id="28758039"/>
    <dbReference type="InParanoid" id="A0A177CAH2"/>
    <dbReference type="OrthoDB" id="6132182at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1280.10">
        <property type="entry name" value="Di-copper center containing domain from catechol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008922">
        <property type="entry name" value="Di-copper_centre_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050316">
        <property type="entry name" value="Tyrosinase/Hemocyanin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002227">
        <property type="entry name" value="Tyrosinase_Cu-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474:SF125">
        <property type="entry name" value="N-ACETYL-6-HYDROXYTRYPTOPHAN OXIDASE IVOB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474">
        <property type="entry name" value="TYROSINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00264">
        <property type="entry name" value="Tyrosinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00092">
        <property type="entry name" value="TYROSINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48056">
        <property type="entry name" value="Di-copper centre-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00497">
        <property type="entry name" value="TYROSINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00498">
        <property type="entry name" value="TYROSINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008057947" evidence="4">
        <location>
            <begin position="29"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosinase copper-binding" evidence="5">
        <location>
            <begin position="98"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosinase copper-binding" evidence="6">
        <location>
            <begin position="283"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAG04575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="361" mass="38635" checksum="4583FCFD79FBDB75" modified="2016-09-07" version="1">MAGGSTLRGLYALLVALSLLSALCAADAVSDLQAKGRAAVDAEVAKGDITAAEKKAYIAAVLCITKAPSKLPAASYPGAKSRYDDFVAIHMKNTMSIHGTGNFLSWHRYFTFAYEQALRTECGYNGTQPYWDWGRWASSPETSPIFDGSETSMSGQGEKVTHNSNGMKPAGNGGGCIASGPFKDMKSYMLTIYSPMAALGDTSPPKNPRSDGYGYNPRCIKRDISGYLTQRDATTAKIAALISGQSTIGNFQNQMQSGTGVHPAGHFTISGDPGSDFYVSPGDPAFWLHHGMVDRVWYIWQTQDFSKRQQVIAGGTSMMGGGKAATLNDGVDLEVLNVDGKKYAIKDLVSTVAGPFCYVYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2023-06-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CBF1</accession>
    <name>A0A177CBF1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_794927</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG04521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034886.1">
        <property type="nucleotide sequence ID" value="XM_018187434.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CBF1"/>
    <dbReference type="GeneID" id="28770920"/>
    <dbReference type="InParanoid" id="A0A177CBF1"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG04521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="88" mass="9746" checksum="55E5EE0184072C0C" modified="2016-09-07" version="1">MNLERVAECKPEDASGITMQANPVHVSILLASSWYSSHSYCVLQTRISFKLKDVSLVCLSRDTIVSASAINYLYITMTVSIYGIRVSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CBU5</accession>
    <name>A0A177CBU5_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Metallo-beta-lactamase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1197684</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG04228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034593.1">
        <property type="nucleotide sequence ID" value="XM_018181536.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CBU5"/>
    <dbReference type="GeneID" id="28765022"/>
    <dbReference type="InParanoid" id="A0A177CBU5"/>
    <dbReference type="OrthoDB" id="449487at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG04228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="288" mass="31687" checksum="9EB4F394287A04A1" modified="2016-09-07" version="1">MRHTFISSVIGRTTSASAQNIAVSTYAPLPSNASSPPINKSTSYRLETFMEGICMVTDGIYYNIFFVKCCSVIVIDAPPTIGTNLLRAICNITSLPISQVMYSHSHIGHIGGAFFSSSSFGSLKIDTFIGHNETAERFAAVQDYQHQPYPTVTFSDLYTLNVCNQTLQLDYLGLNHEPGNIVTYAPYQKVFTPREYVQDLFNTCLAALTASGQPDDNGTNTLSNEVTLRGVVKANPNNAWREGVVNETIGQWNDALYDMNVYGLSHAQTLSEAVRVDWGIQRPYGVVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CBX5</accession>
    <name>A0A177CBX5_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Phenol 2-monooxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CC84DRAFT_895961</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PheA/TfdB FAD monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG04258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034623.1">
        <property type="nucleotide sequence ID" value="XM_018187819.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CBX5"/>
    <dbReference type="STRING" id="1460663.A0A177CBX5"/>
    <dbReference type="GeneID" id="28771305"/>
    <dbReference type="InParanoid" id="A0A177CBX5"/>
    <dbReference type="OrthoDB" id="1716816at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016709">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02979">
        <property type="entry name" value="PHOX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012941">
        <property type="entry name" value="Phe_hydrox_C_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038220">
        <property type="entry name" value="PHOX_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050641">
        <property type="entry name" value="RIFMO-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004:SF20">
        <property type="entry name" value="2-MONOOXYGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G13660)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004">
        <property type="entry name" value="TRK SYSTEM POTASSIUM UPTAKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07976">
        <property type="entry name" value="Phe_hydrox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="5">
        <location>
            <begin position="10"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="Phenol hydroxylase-like C-terminal dimerisation" evidence="6">
        <location>
            <begin position="457"/>
            <end position="664"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAG04258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="665" mass="74277" checksum="9730C8560A805553" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CCS6</accession>
    <name>A0A177CCS6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1259941</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG04578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034943.1">
        <property type="nucleotide sequence ID" value="XM_018184951.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CCS6"/>
    <dbReference type="GeneID" id="28768437"/>
    <dbReference type="InParanoid" id="A0A177CCS6"/>
    <dbReference type="OrthoDB" id="10522320at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG04578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="207" mass="23258" checksum="8F4140EF15FB4F58" modified="2016-09-07" version="1">MARFCDPLPQSEQLSHSPAGKSVWKACLVSLQATSQRCHFGNPNSNLRLKQPDSTNIPRSIPSHTLPKPADVSAHVPAQNYLLPTSQTQMPPPMTKPADLSPRSSSLHTRPSLPYVFFLVKQLVPFTDPVRATQMSFNDATTAHAALLDYVRNNHPYHRSIEPRAGVRRGGGGRVMEGYIAEYEYRDGDWIDEEVVGWVWVERDWRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CCY4</accession>
    <name>A0A177CCY4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Diphthamide biosynthesis protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CC84DRAFT_1187913</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>2 [3Fe-4S](0)-[protein] + 2 Fe(2+)-[Dph3] + NADH = 2 [4Fe-4S](1+)-[protein] + 2 [Dph3] + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:71239"/>
            <dbReference type="Rhea" id="RHEA-COMP:17997"/>
            <dbReference type="Rhea" id="RHEA-COMP:17998"/>
            <dbReference type="Rhea" id="RHEA-COMP:18001"/>
            <dbReference type="Rhea" id="RHEA-COMP:18002"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:33723"/>
            <dbReference type="ChEBI" id="CHEBI:47402"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:83228"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>[3Fe-4S](1+)-[protein] + Fe(2+)-[Dph3] = [3Fe-4S](0)-[protein] + Fe(3+)-[Dph3]</text>
            <dbReference type="Rhea" id="RHEA:71235"/>
            <dbReference type="Rhea" id="RHEA-COMP:17996"/>
            <dbReference type="Rhea" id="RHEA-COMP:17997"/>
            <dbReference type="Rhea" id="RHEA-COMP:18002"/>
            <dbReference type="Rhea" id="RHEA-COMP:18003"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:33751"/>
            <dbReference type="ChEBI" id="CHEBI:47402"/>
            <dbReference type="ChEBI" id="CHEBI:83228"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the DPH3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG05041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035406.1">
        <property type="nucleotide sequence ID" value="XM_018180963.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CCY4"/>
    <dbReference type="FunCoup" id="A0A177CCY4">
        <property type="interactions" value="330"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CCY4"/>
    <dbReference type="GeneID" id="28764449"/>
    <dbReference type="InParanoid" id="A0A177CCY4"/>
    <dbReference type="OrthoDB" id="66964at2759"/>
    <dbReference type="UniPathway" id="UPA00559"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.660.10:FF:000001">
        <property type="entry name" value="Diphthamide biosynthesis 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.660.10">
        <property type="entry name" value="DPH Zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044248">
        <property type="entry name" value="DPH3/4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007872">
        <property type="entry name" value="DPH_MB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036671">
        <property type="entry name" value="DPH_MB_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21454:SF31">
        <property type="entry name" value="DIPHTHAMIDE BIOSYNTHESIS PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21454">
        <property type="entry name" value="DPH3 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05207">
        <property type="entry name" value="Zn_ribbon_CSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144217">
        <property type="entry name" value="CSL zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51074">
        <property type="entry name" value="DPH_MB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DPH-type MB" evidence="9">
        <location>
            <begin position="8"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00036267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00041070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAG05041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="84" mass="9465" checksum="EE5D10DAF4BC1842" modified="2016-09-07" version="1">MADEDVNLYDEIEIEDCFYDETLQIYHHPCPCGDRFEISLGDMRDGEDIARCPSCSLMIRIIFDPSDLPPEPKDDAPQAAAITA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CD09</accession>
    <name>A0A177CD09_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">STE3-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CC84DRAFT_1195944</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG05523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035888.1">
        <property type="nucleotide sequence ID" value="XM_018181425.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CD09"/>
    <dbReference type="FunCoup" id="A0A177CD09">
        <property type="interactions" value="68"/>
    </dbReference>
    <dbReference type="GeneID" id="28764911"/>
    <dbReference type="InParanoid" id="A0A177CD09"/>
    <dbReference type="OrthoDB" id="2874149at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004932">
        <property type="term" value="F:mating-type factor pheromone receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000750">
        <property type="term" value="P:pheromone-dependent signal transduction involved in conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14966">
        <property type="entry name" value="7tmD_STE3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001499">
        <property type="entry name" value="GPCR_STE3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28097">
        <property type="entry name" value="PHEROMONE A FACTOR RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28097:SF1">
        <property type="entry name" value="PHEROMONE A FACTOR RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02076">
        <property type="entry name" value="STE3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00899">
        <property type="entry name" value="GPCRSTE3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0589">Pheromone response</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="39"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="81"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="172"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="215"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OAG05523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="480" mass="54045" checksum="1C3472117B22BBE6" modified="2016-09-07" version="1">MAEGHFPLYPQAVWLPVLAFPSWILCISPMVWHLSQRNIAAGSLIFWIILLNFFNAINPLIWPRDNMEEWYNGSGLCDIEVRVQVGASVALAACTAIIARRLANVMDTRNITVAPSKRSVLIEKALEIGFCWVYPIILMVTYYIVQPFRYYIFGISGCVAVYDSSWPSLAIVWVWGCITTLVAAFYSGLLGFRLFHYRREFHNLIAARNTTKSRFVRLFLMALYVSIILVPYSFFILYQLADTIVDDYSWSRVHGPNWNSVTKVPANGVVRWDRWGEVAAGYIAFILFGTGTDAHNTYKGILTSVGFGKLFPSLYIMSESSGVQTPTGVTFVKRWTSSWSTKAKSWISRNDSVSEPSRNESFTGSVVHSVFTNPELVTVQQQQVKPPNNTLSIFSRNLNRRTTNQSILPIQNKMSTDTDRLPVLDKTPSNPSAFIARAWAAEKYTGEKADEIAGVHVVCEVHQASQDRSGEKKTGDDAWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CDI6</accession>
    <name>A0A177CDI6_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Adenylate kinase isoenzyme 6 homolog</fullName>
            <shortName evidence="10">AK6</shortName>
            <ecNumber evidence="10">2.7.4.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Dual activity adenylate kinase/ATPase</fullName>
            <shortName evidence="10">AK/ATPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CC84DRAFT_1164172</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Has also ATPase activity. Involved in the late cytoplasmic maturation steps of the 40S ribosomal particles, specifically 18S rRNA maturation. While NMP activity is not required for ribosome maturation, ATPase activity is. Associates transiently with small ribosomal subunit protein uS11. ATP hydrolysis breaks the interaction with uS11. May temporarily remove uS11 from the ribosome to enable a conformational change of the ribosomal RNA that is needed for the final maturation step of the small ribosomal subunit. Its NMP activity may have a role in nuclear energy homeostasis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>AMP + ATP = 2 ADP</text>
            <dbReference type="Rhea" id="RHEA:12973"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="10">Interacts with small ribosomal subunit protein uS11. Not a structural component of 43S pre-ribosomes, but transiently interacts with them by binding to uS11.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the adenylate kinase family. AK6 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.3" evidence="10"/>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG05705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036070.1">
        <property type="nucleotide sequence ID" value="XM_018178434.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CDI6"/>
    <dbReference type="FunCoup" id="A0A177CDI6">
        <property type="interactions" value="828"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CDI6"/>
    <dbReference type="GeneID" id="28761920"/>
    <dbReference type="InParanoid" id="A0A177CDI6"/>
    <dbReference type="OrthoDB" id="10251185at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004017">
        <property type="term" value="F:AMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000372">
        <property type="entry name" value="Adenylate kinase isoenzyme 6 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00039">
        <property type="entry name" value="Adenylate_kinase_AK6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020618">
        <property type="entry name" value="Adenyl_kinase_AK6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12595:SF0">
        <property type="entry name" value="ADENYLATE KINASE ISOENZYME 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12595">
        <property type="entry name" value="POS9-ACTIVATING FACTOR FAP7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13238">
        <property type="entry name" value="AAA_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4 10" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="5 10" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="NMPbind" evidence="10">
        <location>
            <begin position="35"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="LID" evidence="10">
        <location>
            <begin position="112"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="15"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="17"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="19"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="20"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OAG05705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="180" mass="20467" checksum="E3C50EBF7FE43F50" modified="2016-09-07" version="1">MARQNPNIVITGTPGVGKTTHAEQLARNLGFTHVSVNQIVKDEGFHEGRDEELGSWVVDEDKLLDHLEATGISEKGGNILDWHACELFPERWIDLVIVLRCDSTVLYDRLTARGYKGKKLEENMDSEIMQVLLDEARESYKEEIVVELQSSGDGDVDGNVERIEQWVEQWRKDNEGKSEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CEQ0</accession>
    <name>A0A177CEQ0_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">TPR-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CC84DRAFT_1092411</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG05786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036151.1">
        <property type="nucleotide sequence ID" value="XM_018174450.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CEQ0"/>
    <dbReference type="FunCoup" id="A0A177CEQ0">
        <property type="interactions" value="940"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CEQ0"/>
    <dbReference type="GeneID" id="28757936"/>
    <dbReference type="InParanoid" id="A0A177CEQ0"/>
    <dbReference type="OrthoDB" id="343875at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016593">
        <property type="term" value="C:Cdc73/Paf1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000993">
        <property type="term" value="F:RNA polymerase II complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031101">
        <property type="entry name" value="Ctr9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001289">
        <property type="entry name" value="NFYA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14027">
        <property type="entry name" value="RNA POLYMERASE-ASSOCIATED PROTEIN CTR9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14027:SF2">
        <property type="entry name" value="RNA POLYMERASE-ASSOCIATED PROTEIN CTR9 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13174">
        <property type="entry name" value="TPR_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51152">
        <property type="entry name" value="NFYA_HAP2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 8" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="repeat" description="TPR" evidence="8">
        <location>
            <begin position="791"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="8">
        <location>
            <begin position="832"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="941"/>
            <end position="984"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1000"/>
            <end position="1181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="943"/>
            <end position="984"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1000"/>
            <end position="1027"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="1028"/>
            <end position="1042"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1094"/>
            <end position="1106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="1107"/>
            <end position="1117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="1125"/>
            <end position="1137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="1150"/>
            <end position="1159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAG05786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1181" mass="133101" checksum="4B1289DB3CCC08D5" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CEV2</accession>
    <name>A0A177CEV2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1164493</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG06163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036528.1">
        <property type="nucleotide sequence ID" value="XM_018178497.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CEV2"/>
    <dbReference type="GeneID" id="28761983"/>
    <dbReference type="InParanoid" id="A0A177CEV2"/>
    <dbReference type="OrthoDB" id="3886018at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG06163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="103" mass="11386" checksum="2B46F3A64C544289" modified="2016-09-07" version="1">MTATQRKYWEEYRMPECIVIQDTDSVYPKASHFKPLLIDDLVPGLPASHPRLIEYGNSAEGASVVKSESDYHGKVIVSYDSATGAHEVWMAAASMTEPILKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CEZ0</accession>
    <name>A0A177CEZ0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1243603</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG05389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035754.1">
        <property type="nucleotide sequence ID" value="XM_018184119.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CEZ0"/>
    <dbReference type="STRING" id="1460663.A0A177CEZ0"/>
    <dbReference type="GeneID" id="28767605"/>
    <dbReference type="InParanoid" id="A0A177CEZ0"/>
    <dbReference type="OrthoDB" id="5355526at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="248"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="276"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG05389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="302" mass="33707" checksum="1F4DDC365CBFF6C8" modified="2016-09-07" version="1">MFGLRFIDGQETAQTSLESSTQIFILPRPLLWLNRVYVRLKTMLGKPLERNVLPQHSGNTTTTHSLQRTPTQPQRLLHLLTSMRSARLGKGLYQGCIDAIKTDRQLFDFLRDLYKSKRGHIRTLCSLKTVKGIHIVGFNLFAGGAVEVRHHKECCKQDCTCLPPAALVQPSENAEYQCYPAGPLKYGPPILPEVLAHFYSSPSCIPEHVRSVLDRLPIRIVGELHEPIGEPAQGWGIYFHEGLDSDMITLLVFVMFFTGSLIFGILWSYLKMDVQGAFGVSAYILTAGAILVSLVAMKANKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CH04</accession>
    <name>A0A177CH04_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">glutamine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CC84DRAFT_1091365</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>tRNA(Gln) + L-glutamine + ATP = L-glutaminyl-tRNA(Gln) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:20121"/>
            <dbReference type="Rhea" id="RHEA-COMP:9662"/>
            <dbReference type="Rhea" id="RHEA-COMP:9681"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78521"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.18"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.18" evidence="2"/>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG05987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036352.1">
        <property type="nucleotide sequence ID" value="XM_018174398.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CH04"/>
    <dbReference type="FunCoup" id="A0A177CH04">
        <property type="interactions" value="1292"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CH04"/>
    <dbReference type="GeneID" id="28757884"/>
    <dbReference type="InParanoid" id="A0A177CH04"/>
    <dbReference type="OrthoDB" id="10250478at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004819">
        <property type="term" value="F:glutamine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990825">
        <property type="term" value="F:sequence-specific mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006425">
        <property type="term" value="P:glutaminyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.240.10:FF:000007">
        <property type="entry name" value="Glutamine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000183">
        <property type="entry name" value="Glutaminyl-tRNA synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.240.10">
        <property type="entry name" value="Ribosomal Protein L25, Chain P"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004514">
        <property type="entry name" value="Gln-tRNA-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050132">
        <property type="entry name" value="Gln/Glu-tRNA_Ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000924">
        <property type="entry name" value="Glu/Gln-tRNA-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020058">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020059">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_codon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020056">
        <property type="entry name" value="Rbsml_bL25/Gln-tRNA_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011035">
        <property type="entry name" value="Ribosomal_bL25/Gln-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049437">
        <property type="entry name" value="tRNA-synt_1c_C2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00440">
        <property type="entry name" value="glnS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43097:SF4">
        <property type="entry name" value="GLUTAMINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43097">
        <property type="entry name" value="GLUTAMINE-TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00749">
        <property type="entry name" value="tRNA-synt_1c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03950">
        <property type="entry name" value="tRNA-synt_1c_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20974">
        <property type="entry name" value="tRNA-synt_1c_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00987">
        <property type="entry name" value="TRNASYNTHGLU"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50715">
        <property type="entry name" value="Ribosomal protein L25-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9 14" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic" evidence="11">
        <location>
            <begin position="83"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="domain" description="Glutamyl/glutaminyl-tRNA synthetase class Ib anti-codon binding" evidence="12">
        <location>
            <begin position="425"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA synthetases class I (E and Q) anti-codon binding" evidence="13">
        <location>
            <begin position="534"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="16"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF03950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF20974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OAG05987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="644" mass="73184" checksum="9AA285177F60ABA7" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CH07</accession>
    <name>A0A177CH07_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_755616</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG06232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036597.1">
        <property type="nucleotide sequence ID" value="XM_018187313.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CH07"/>
    <dbReference type="GeneID" id="28770799"/>
    <dbReference type="InParanoid" id="A0A177CH07"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG06232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="75" mass="8503" checksum="172A10A5750ABCF4" modified="2016-09-07" version="1">MGPLSYYKLPRQVRAAFVAALAQRTHHTLLAFHCARVFQNHHASKACNFKRPCLPKESHCGLSALSTLLHHYDHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CHE8</accession>
    <name>A0A177CHE8_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">EF-hand</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CC84DRAFT_1258013</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG06746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037111.1">
        <property type="nucleotide sequence ID" value="XM_018184789.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CHE8"/>
    <dbReference type="STRING" id="1460663.A0A177CHE8"/>
    <dbReference type="GeneID" id="28768275"/>
    <dbReference type="InParanoid" id="A0A177CHE8"/>
    <dbReference type="OrthoDB" id="2122982at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02340">
        <property type="entry name" value="ZZ_NBR1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028846">
        <property type="entry name" value="Recoverin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000433">
        <property type="entry name" value="Znf_ZZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043145">
        <property type="entry name" value="Znf_ZZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23055">
        <property type="entry name" value="CALCIUM BINDING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23055:SF187">
        <property type="entry name" value="EF HAND DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G07310)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00569">
        <property type="entry name" value="ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00450">
        <property type="entry name" value="RECOVERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00291">
        <property type="entry name" value="ZnF_ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01357">
        <property type="entry name" value="ZF_ZZ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50135">
        <property type="entry name" value="ZF_ZZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="ZZ-type" evidence="9">
        <location>
            <begin position="228"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="10">
        <location>
            <begin position="366"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="10">
        <location>
            <begin position="402"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="37"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="550"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="824"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="50"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="566"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="578"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="609"/>
            <end position="618"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OAG06746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1032" mass="116550" checksum="C4F98BBF1887F05D" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CHL3</accession>
    <name>A0A177CHL3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1174646</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG06711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037076.1">
        <property type="nucleotide sequence ID" value="XM_018180106.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CHL3"/>
    <dbReference type="GeneID" id="28763592"/>
    <dbReference type="InParanoid" id="A0A177CHL3"/>
    <dbReference type="OrthoDB" id="5245501at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="453"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="676"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="460"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="479"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="493"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="688"/>
            <end position="697"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG06711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="735" mass="82781" checksum="EF7558F12AF658A3" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CHZ5</accession>
    <name>A0A177CHZ5_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF6594 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_1164742</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG06479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036844.1">
        <property type="nucleotide sequence ID" value="XM_018178551.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CHZ5"/>
    <dbReference type="STRING" id="1460663.A0A177CHZ5"/>
    <dbReference type="GeneID" id="28762037"/>
    <dbReference type="InParanoid" id="A0A177CHZ5"/>
    <dbReference type="OrthoDB" id="5342093at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046529">
        <property type="entry name" value="DUF6594"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34502:SF5">
        <property type="entry name" value="DUF6594 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34502">
        <property type="entry name" value="DUF6594 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20237">
        <property type="entry name" value="DUF6594"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="352"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="378"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="409"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6594" evidence="3">
        <location>
            <begin position="92"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="56"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAG06479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="455" mass="50310" checksum="5B4E501141A17F7F" modified="2016-09-07" version="1">MVSEYVHRQMSLELQEMDSRPSTSDRAPSTPGTATAINTPDQDQFPQHATQPDTVSLSSDLESISSDSENEGDEDGIRTVKGKLPDDAVEGWPQLAQLMADQPEFAAFPRFRDLNVKSLLYYQVELNSLRKKLHRLEHADKAHPRNQDYSLYADTLVNESNASEQLKTMKTIRGVLKEYNEALLQYSKVCALPDPEPFNMRTLRGWLRHEHGGNLNVQDLDDGGPVNTWGLLKNNPDDEEKSLGSQFRSLLCSLLWMRRPEKSMHEPDLALTAPQIQVDGLTHWYASELIPFRRSLSSWKERKKMNVTPDLENTASQDTGQDYRVQTTPPWPKKTKKEDTLVSWSENSALRLTSGISTVVACLLPVIAISVLSQLQGLKALLICLAGFSLVFAIGLIALTQGTSKRTEIFGATAAFSAVMVVFISIPPAPVIMMPPGSAIPSVSPSAVISALPTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CI50</accession>
    <name>A0A177CI50_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RmlC-like cupin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1088471</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG07183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037548.1">
        <property type="nucleotide sequence ID" value="XM_018174254.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CI50"/>
    <dbReference type="STRING" id="1460663.A0A177CI50"/>
    <dbReference type="GeneID" id="28757740"/>
    <dbReference type="InParanoid" id="A0A177CI50"/>
    <dbReference type="OrthoDB" id="5370773at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02215">
        <property type="entry name" value="cupin_QDO_N_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052538">
        <property type="entry name" value="Flavonoid_dioxygenase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43346">
        <property type="entry name" value="LIGAND BINDING DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G14370)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43346:SF1">
        <property type="entry name" value="QUERCETIN 2,3-DIOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008058201" evidence="1">
        <location>
            <begin position="19"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG07183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="372" mass="40182" checksum="65E6FF8E869C68BB" modified="2016-09-07" version="1">MLFIPVFILLGAVAAARGTAKRDNSSLVVTKVPDYVRPYVVRAYTLDGVRIGSQVYRFPVTGPSSDNAFTLISTAAPASSELGVLPHIHQAHYENFYALRGRFALWASKDNTTAGRIFTPGDYGAVPPNTTHSFQILEPFTEMVGVIQPGGFEDLFYFLASANYSSQTYAPFPQGNFTSPGGDAETISKLQKFDVWAQLQFSPPMDFDANGTSGDEGAVWHNGINELASDSATPFFVANGYGRKTLTPASADNASYAVVEPFITATQSEGNFTEGTITLSRLPSSSQPQAWKLPGHTALEVVDGLVGVKVDGYEEELNLSVGDVVFVPAETTWSFWGEAAFSKVLYVGQGRDTVDARLREQGSEWGSVVWPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CIT7</accession>
    <name>A0A177CIT7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative amidohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CC84DRAFT_1163444</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="4">The Mn(2+) ion enhances activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M20 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M20A family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG07226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037591.1">
        <property type="nucleotide sequence ID" value="XM_018178265.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CIT7"/>
    <dbReference type="STRING" id="1460663.A0A177CIT7"/>
    <dbReference type="GeneID" id="28761751"/>
    <dbReference type="InParanoid" id="A0A177CIT7"/>
    <dbReference type="OrthoDB" id="6119954at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.360:FF:000001">
        <property type="entry name" value="N-acetyldiaminopimelate deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017439">
        <property type="entry name" value="Amidohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01891">
        <property type="entry name" value="amidohydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11014:SF63">
        <property type="entry name" value="METALLOPEPTIDASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G09600)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11014">
        <property type="entry name" value="PEPTIDASE M20 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005962">
        <property type="entry name" value="Pept_M20D_amidohydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="Bacterial exopeptidase dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0464">Manganese</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M20 dimerisation" evidence="5">
        <location>
            <begin position="205"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR005962-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAG07226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="426" mass="46333" checksum="6F9DB6C95AD68709" modified="2016-09-07" version="1">MSSSISDLLASKTLDLEPYEQLYKHYHSHPELSNQEKETAATTAKHLSKLADFKITTGIGGHGFAGVLHNGSGPTVLLRADMDALPVKELTNLPYASTVTQVSERTGEESPVMHACGHDMHITCLLAAAEHLYALRSSWSGTLVVLFQPAEERGTGAQAMVDDGLYDKEKHNIPVPDYVLGQHVMALPAGKIGSRVGTIMAAADSFKVTVFGRGGHGSMPHRTIDPVMMASNIVVRLQNIVSRETDPSDMAVVTVGYLRGGHTENIIVDHAELGIDIRTINTATRERVIASLKRIVHAEYIASGAEKEPTIEETRFFPQTYNDEDMEGKLAGSFGEFFGEAFDPQIARTNASEDVSILASSQGKPSLFWFFGGTEPEFYAQKEREGRLIEDIPQNHSSGFAPVIQPTLKIGVDALCVAALTFLTRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CJI2</accession>
    <name>A0A177CJI2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PLC-like phosphodiesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1163772</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG07653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038018.1">
        <property type="nucleotide sequence ID" value="XM_018178334.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CJI2"/>
    <dbReference type="STRING" id="1460663.A0A177CJI2"/>
    <dbReference type="GeneID" id="28761820"/>
    <dbReference type="InParanoid" id="A0A177CJI2"/>
    <dbReference type="OrthoDB" id="7984201at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051057">
        <property type="entry name" value="PI-PLC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593:SF140">
        <property type="entry name" value="PLC-LIKE PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26146">
        <property type="entry name" value="PI-PLC_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008058371" evidence="1">
        <location>
            <begin position="17"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG07653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="449" mass="48443" checksum="B354934157195F22" modified="2016-09-07" version="1">MGPLYLLLWFASLVTAQLESTSVEIITITGSSAISSGEAPAATVPSDFDGSTIATVSLTADVSGSTGATNATASAGSSGASIEATYTRLVGGTRSATSTVLSATSTTSTAAAPVNTQPCNNYPELCERKYSNITEVCAHNSPFVRANNAASNQELTVTQQLNDGIRVLQGQAHYVNGTLYYCHTSCDLLNAGTVEDYLRTVTEWVAAHPFDVITIIFGNYNWQDTDENGNRTVTSKQFAEPIEASGLMQYVYQPPKTAMDLADWPTLGELIIQGKRVITFIDYNFDTDAVPYLLWEFYNIWETPFSPTSEDFTCEIQRPDGLSENKSREMMYMANHNLNVQVSIAGLNLLIPNTAELNITNGVNGPNSLGEMTENCTAMWDRPPNFLLVDYYNHGSPMNGSVFEVAARANNVTYDRKCCGKAASLGVVLKMPSPTCLALAIAVIVALLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CJT6</accession>
    <name>A0A177CJT6_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">COX assembly mitochondrial protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CC84DRAFT_1163899</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for mitochondrial cytochrome c oxidase (COX) assembly and respiration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the CMC family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG07785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038150.1">
        <property type="nucleotide sequence ID" value="XM_018178358.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CJT6"/>
    <dbReference type="STRING" id="1460663.A0A177CJT6"/>
    <dbReference type="GeneID" id="28761844"/>
    <dbReference type="InParanoid" id="A0A177CJT6"/>
    <dbReference type="OrthoDB" id="6224010at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013892">
        <property type="entry name" value="Cyt_c_biogenesis_Cmc1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22977">
        <property type="entry name" value="COX ASSEMBLY MITOCHONDRIAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22977:SF5">
        <property type="entry name" value="COX ASSEMBLY MITOCHONDRIAL PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08583">
        <property type="entry name" value="Cmc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="133"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="12"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU364104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAG07785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="155" mass="17808" checksum="F5EB40877266C9F4" modified="2016-09-07" version="1">MAMATPTDQAPPAIPRLPSNPTPLSAPQEQQVRDLYYRNVRAKCASEIAAFAECATGRTFTMIYACRAQKLTMNTCMLQYQGPDELDKARAEWFALAGERRREKEERAKLVEESKRRHKEWWGLDEHGKLQGKKLETKLERETREAGERAAEGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CJV2</accession>
    <name>A0A177CJV2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_520655</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG07814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038179.1">
        <property type="nucleotide sequence ID" value="XM_018186604.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CJV2"/>
    <dbReference type="GeneID" id="28770090"/>
    <dbReference type="InParanoid" id="A0A177CJV2"/>
    <dbReference type="OrthoDB" id="4932058at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008058382" evidence="1">
        <location>
            <begin position="23"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG07814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="283" mass="30574" checksum="3CFE749D31DA3249" modified="2016-09-07" version="1">MITMGPFAFLSVLLSLPWNIGGVGTCGTADIVGNSVANCDCPTRTSLTPSCGGKGMKCNDPYCHVDTTGELVECFEGCVQGNIECDACYLYFHSLCLCMKKSSLNCIQSGDWWLLNDHKLITTSKKVPGILQLGSDNGGWEFGQSLLGAGTVASRQWGTLSVNSVLSRDEEQIHIHVCDNPSSALRTHLSTLNWYDFKDKPKPLLVPIAGNSRFPAGTVQCQAALNPGTHMDVAEITSKYVNSLGGCEREKVGAGLITDKNDYSWVCLTTMDDHAAVQLFCYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CJX5</accession>
    <name>A0A177CJX5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CC84DRAFT_1143690</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG07272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037637.1">
        <property type="nucleotide sequence ID" value="XM_018176427.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CJX5"/>
    <dbReference type="GeneID" id="28759913"/>
    <dbReference type="InParanoid" id="A0A177CJX5"/>
    <dbReference type="OrthoDB" id="1606438at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016461">
        <property type="entry name" value="COMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001077">
        <property type="entry name" value="COMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712:SF12">
        <property type="entry name" value="STERIGMATOCYSTIN 8-O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00891">
        <property type="entry name" value="Methyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51683">
        <property type="entry name" value="SAM_OMT_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="O-methyltransferase C-terminal" evidence="4">
        <location>
            <begin position="6"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAG07272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="141" mass="16302" checksum="553DE791FA0B325E" modified="2016-09-07" version="1">MRHLDMTAVVLDLPKIIFAAPKSSERVTFEANDFFAQESVQKADLYLSRMIFHNWGDKYYSQILQNLISALRKGSRIAINDHVIPSPGVLSPYKDWTTRVVDLVMKEYFNAKERDISVWIKLLKKADGRCEIRNVIRLEGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CKA1</accession>
    <name>A0A177CKA1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fungal calcium binding protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1163789</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG07671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038036.1">
        <property type="nucleotide sequence ID" value="XM_018178338.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CKA1"/>
    <dbReference type="GeneID" id="28761824"/>
    <dbReference type="InParanoid" id="A0A177CKA1"/>
    <dbReference type="OrthoDB" id="4588160at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008058295" description="Fungal calcium binding protein domain-containing protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG07671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="101" mass="10911" checksum="65B64FF3F6AA8CD9" modified="2016-09-07" version="1">MTMYSFFAVVTLFILVATAAAQDLCPKDEYACLDIINSSQCLAQLVIQKMSPLTKENMAKCVETEGVASSLPGAQKLCRCPGCHTEPINAAIRELFPPPCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CLA3</accession>
    <name>A0A177CLA3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CC84DRAFT_1087626</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038658.1">
        <property type="nucleotide sequence ID" value="XM_018174210.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CLA3"/>
    <dbReference type="GeneID" id="28757696"/>
    <dbReference type="InParanoid" id="A0A177CLA3"/>
    <dbReference type="OrthoDB" id="544685at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005262">
        <property type="term" value="F:calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023408">
        <property type="entry name" value="MscS_beta-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006685">
        <property type="entry name" value="MscS_channel_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058650">
        <property type="entry name" value="Msy1/2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31323">
        <property type="entry name" value="MECHANOSENSITIVE ION CHANNEL PROTEIN MSY2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31323:SF14">
        <property type="entry name" value="MECHANOSENSITIVE ION CHANNEL PROTEIN MSY2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00924">
        <property type="entry name" value="MS_channel_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25886">
        <property type="entry name" value="Msy1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="127"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="204"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="438"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="473"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="8">
        <location>
            <begin position="386"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="677"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="724"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="22"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="729"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="788"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="812"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="835"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="867"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="893"/>
            <end position="905"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAG08293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="905" mass="99685" checksum="108B3C830B5529E0" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2023-06-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CLS4</accession>
    <name>A0A177CLS4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_580608</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038869.1">
        <property type="nucleotide sequence ID" value="XM_018186752.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CLS4"/>
    <dbReference type="GeneID" id="28770238"/>
    <dbReference type="InParanoid" id="A0A177CLS4"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG08504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="180" mass="20152" checksum="6CA1654C578415E4" modified="2016-09-07" version="1">MLFADAIPSSPKRTCILLLPFGVHSFSLLHSVSTLSSCCRRGSFEAYGSRISWIIKDREPAWLPWQTVCQLFLLYMLQSPGPERSNSAATGRAQPDCPTSQSLRSGRVYHSNPSQVTHRRLLTPNALEFKRALDQDPQSFWHYPGDIVLNSNLSVESAHPTLPLVFRASVTSSYRSTTRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CLX1</accession>
    <name>A0A177CLX1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10 11">Endo-1,4-beta-xylanase</fullName>
            <ecNumber evidence="4 10 11">3.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CC84DRAFT_1141383</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10 11">
            <text>Endohydrolysis of (1-&gt;4)-beta-D-xylosidic linkages in xylans.</text>
            <dbReference type="EC" id="3.2.1.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 10 11">Glycan degradation; xylan degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10 11">Belongs to the glycosyl hydrolase 11 (cellulase G) family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.8" evidence="4 10 11"/>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038919.1">
        <property type="nucleotide sequence ID" value="XM_018176324.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CLX1"/>
    <dbReference type="GeneID" id="28759810"/>
    <dbReference type="InParanoid" id="A0A177CLX1"/>
    <dbReference type="OrthoDB" id="2115822at2759"/>
    <dbReference type="UniPathway" id="UPA00114"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031176">
        <property type="term" value="F:endo-1,4-beta-xylanase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013319">
        <property type="entry name" value="GH11/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018208">
        <property type="entry name" value="GH11_AS_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033123">
        <property type="entry name" value="GH11_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001137">
        <property type="entry name" value="Glyco_hydro_11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46828">
        <property type="entry name" value="ENDO-1,4-BETA-XYLANASE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46828:SF2">
        <property type="entry name" value="ENDO-1,4-BETA-XYLANASE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00457">
        <property type="entry name" value="Glyco_hydro_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00911">
        <property type="entry name" value="GLHYDRLASE11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00776">
        <property type="entry name" value="GH11_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51761">
        <property type="entry name" value="GH11_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10 11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8 10 11" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 10 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 10 11" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="5 10 11" id="KW-0858">Xylan degradation</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008058358" description="Endo-1,4-beta-xylanase" evidence="12">
        <location>
            <begin position="22"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="GH11" evidence="13">
        <location>
            <begin position="23"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="10">
        <location>
            <position position="108"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10">
        <location>
            <position position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OAG08554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="215" mass="23570" checksum="E850CB356DB7B3AA" modified="2016-09-07" version="1">MCQASAFIFLLILQSWQGAAAASHAIQSPRPRANWFNSFWTDTAASVKYKNLPEGAYSVTWNGTGNFVGGKGWNPGSTSKVVNWTGSFEPNGYAYLTVYGWTTNPLVEYYIVENYHPDHEPAAPPEGEVVTNLTSDGSLYSVRTKMRVDKPSIIGTATFRQIFSVRQDKRSEGVVTVGNHFAAWKEAGLKTGTQNYMVMATEGNNSSGKASIEVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CMB4</accession>
    <name>A0A177CMB4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">endo-1,3(4)-beta-glucanase</fullName>
            <ecNumber evidence="3">3.2.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CC84DRAFT_1174138</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endohydrolysis of (1-&gt;3)- or (1-&gt;4)-linkages in beta-D-glucans when the glucose residue whose reducing group is involved in the linkage to be hydrolyzed is itself substituted at C-3.</text>
            <dbReference type="EC" id="3.2.1.6"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 16 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.6" evidence="3"/>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039059.1">
        <property type="nucleotide sequence ID" value="XM_018180079.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CMB4"/>
    <dbReference type="STRING" id="1460663.A0A177CMB4"/>
    <dbReference type="GeneID" id="28763565"/>
    <dbReference type="InParanoid" id="A0A177CMB4"/>
    <dbReference type="OrthoDB" id="192832at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052861">
        <property type="term" value="F:endo-1,3(4)-beta-glucanase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02181">
        <property type="entry name" value="GH16_fungal_Lam16A_glucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000114">
        <property type="entry name" value="Probable endo-1,3(4)-beta-glucanase NFIA_089530"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF24">
        <property type="entry name" value="GLYCOSIDASE C21B10.07-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26113">
        <property type="entry name" value="GH16_XgeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008058379" description="endo-1,3(4)-beta-glucanase" evidence="7">
        <location>
            <begin position="19"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="8">
        <location>
            <begin position="15"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="319"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="383"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="324"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="402"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="421"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAG08694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="575" mass="59947" checksum="C45AE0462D343DE7" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CMD6</accession>
    <name>A0A177CMD6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1239055</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG07969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038334.1">
        <property type="nucleotide sequence ID" value="XM_018183970.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CMD6"/>
    <dbReference type="GeneID" id="28767456"/>
    <dbReference type="InParanoid" id="A0A177CMD6"/>
    <dbReference type="OrthoDB" id="3792274at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG07969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="401" mass="45688" checksum="29557F71F43DA828" modified="2016-09-07" version="1">MACPKKGLQAASLWPDGGDLEFIVWQKKQSVKVSPLKKYISGAEEYHRYMSRNRATSTGSFSISSLIAFFLRATLEPKQPECGHELHPSAAVETFCPVCQVDHCIAFLDAISEAWEAAGGPFRGDYEPKSYSHRYINLRRGWRVARLELINLVAKLEKQAIMENRMDFYTLPAETLDEPDDSLPIVYGTQAALIRYRLAYKYPAVNVTRQIEDDWHTPGSSLRQKKEVHFDKDLVDGSTRKYESFNRKHPDYVRGPHSVSPGSQFENTTCTHDVEVLVAQSKIFFTSMLGFKVFAEKPTHWPEFEGIAGCHPRWEEILVSLGTYAFWRSRRKFGEWEKKLESSGVDGIAIVENHGRIVDFVVLKAPKENLHNPIKRNANWVSLSDAESEERTFVSVPGVDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CMH1</accession>
    <name>A0A177CMH1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 15">Signal peptidase complex catalytic subunit SEC11</fullName>
            <ecNumber evidence="4 15">3.4.21.89</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CC84DRAFT_1114377</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalytic component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Specifically cleaves N-terminal signal peptides that contain a hydrophobic alpha-helix (h-region) shorter than 18-20 amino acids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 15">
            <text>Cleavage of hydrophobic, N-terminal signal or leader sequences from secreted and periplasmic proteins.</text>
            <dbReference type="EC" id="3.4.21.89"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="14">Component of the signal peptidase complex (SPC) composed of a catalytic subunit SEC11 and three accessory subunits SPC1, SPC2 and SPC3. The complex induces a local thinning of the ER membrane which is used to measure the length of the signal peptide (SP) h-region of protein substrates. This ensures the selectivity of the complex towards h-regions shorter than 18-20 amino acids. SPC associates with the translocon complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the peptidase S26B family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.89" evidence="4 15"/>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038507.1">
        <property type="nucleotide sequence ID" value="XM_018175394.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CMH1"/>
    <dbReference type="FunCoup" id="A0A177CMH1">
        <property type="interactions" value="669"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CMH1"/>
    <dbReference type="GeneID" id="28758880"/>
    <dbReference type="InParanoid" id="A0A177CMH1"/>
    <dbReference type="OrthoDB" id="10257561at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005787">
        <property type="term" value="C:signal peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009003">
        <property type="term" value="F:signal peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06530">
        <property type="entry name" value="S26_SPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019756">
        <property type="entry name" value="Pept_S26A_signal_pept_1_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019533">
        <property type="entry name" value="Peptidase_S26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001733">
        <property type="entry name" value="Peptidase_S26B"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02228">
        <property type="entry name" value="sigpep_I_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10806">
        <property type="entry name" value="SIGNAL PEPTIDASE COMPLEX CATALYTIC SUBUNIT SEC11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10806:SF6">
        <property type="entry name" value="SIGNAL PEPTIDASE COMPLEX CATALYTIC SUBUNIT SEC11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00728">
        <property type="entry name" value="SIGNALPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="LexA/Signal peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00501">
        <property type="entry name" value="SPASE_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 15" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 15" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 15" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="7 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="132"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU362047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OAG08142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="173" mass="19057" checksum="1AB685ED2CDF9AF9" modified="2016-09-07" version="1">MMGIANMQPRQLATQVLNFALVLSTAFMLWKGISVVADSPSPIVVVLSGSMEPAFQRGDLLFLWNRGLDTQLGEVVVYNVKGKDIPIVHRVVRRFGGGKSPLRLLTKGDNNLADDTELYAAGQTHLNRKEDVIGSVVGFIPFVGYVTILLSEYPWLKQAMLGIMGLMVVLQRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CMI2</accession>
    <name>A0A177CMI2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Glycoside hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CC84DRAFT_1115046</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038871.1">
        <property type="nucleotide sequence ID" value="XM_018175418.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CMI2"/>
    <dbReference type="STRING" id="1460663.A0A177CMI2"/>
    <dbReference type="GeneID" id="28758904"/>
    <dbReference type="InParanoid" id="A0A177CMI2"/>
    <dbReference type="OrthoDB" id="4215304at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009254">
        <property type="term" value="P:peptidoglycan turnover"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.300:FF:000008">
        <property type="entry name" value="Beta-N-acetylglucosaminidase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1700:FF:000013">
        <property type="entry name" value="Glycoside hydrolase family 3 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050226">
        <property type="entry name" value="NagZ_Beta-hexosaminidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30480">
        <property type="entry name" value="BETA-HEXOSAMINIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30480:SF8">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_8G04060)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase family 3 N-terminal" evidence="6">
        <location>
            <begin position="15"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetyltransferase" evidence="5">
        <location>
            <begin position="636"/>
            <end position="708"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAG08506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="932" mass="101473" checksum="A19904C7BE38E4B7" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CMI3</accession>
    <name>A0A177CMI3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF7730 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_1256956</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038384.1">
        <property type="nucleotide sequence ID" value="XM_018184681.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CMI3"/>
    <dbReference type="GeneID" id="28768167"/>
    <dbReference type="InParanoid" id="A0A177CMI3"/>
    <dbReference type="OrthoDB" id="5413827at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056632">
        <property type="entry name" value="DUF7730"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38790:SF4">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38790">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24864">
        <property type="entry name" value="DUF7730"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7730" evidence="3">
        <location>
            <begin position="53"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="464"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="338"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="464"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="499"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="529"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="635"/>
            <end position="648"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAG08019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="648" mass="74149" checksum="AA9DB351EC09876D" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CMJ8</accession>
    <name>A0A177CMJ8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Bys1 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1240297</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039139.1">
        <property type="nucleotide sequence ID" value="XM_018184013.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CMJ8"/>
    <dbReference type="STRING" id="1460663.A0A177CMJ8"/>
    <dbReference type="GeneID" id="28767499"/>
    <dbReference type="InParanoid" id="A0A177CMJ8"/>
    <dbReference type="OrthoDB" id="3682664at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006771">
        <property type="entry name" value="CetA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36195:SF4">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G01990)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36195">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G01990)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04681">
        <property type="entry name" value="Bys1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008058372" evidence="1">
        <location>
            <begin position="18"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG08774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="151" mass="15459" checksum="F30A1DCC43D6D760" modified="2016-09-07" version="1">MYYTLAVLTALASSAAAVGNAVVVNKCSSTIYAWSVGSSVGTKQTIATGKNFTEPLHSDAKSGGIALKITTVDDGLYNGSPQQIFSYSLDGASVWYVYDLSTAFGEPFLGKRITVTSTGSPSIVWANGSNPGGSQVKVGVSGVDVVFTGCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CMU4</accession>
    <name>A0A177CMU4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Delta(24)-sterol reductase</fullName>
            <ecNumber evidence="2">1.3.1.72</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CC84DRAFT_1162521</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="1.3.1.72" evidence="2"/>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038971.1">
        <property type="nucleotide sequence ID" value="XM_018178016.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CMU4"/>
    <dbReference type="STRING" id="1460663.A0A177CMU4"/>
    <dbReference type="GeneID" id="28761502"/>
    <dbReference type="InParanoid" id="A0A177CMU4"/>
    <dbReference type="OrthoDB" id="415825at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000246">
        <property type="term" value="F:Delta24(24-1) sterol reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050614">
        <property type="term" value="F:Delta24-sterol reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008202">
        <property type="term" value="P:steroid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.465.10:FF:000031">
        <property type="entry name" value="FAD binding domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040165">
        <property type="entry name" value="Diminuto-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10801">
        <property type="entry name" value="24-DEHYDROCHOLESTEROL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10801:SF10">
        <property type="entry name" value="FAD BINDING DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G14300)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="6">
        <location>
            <begin position="1"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAG08606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="493" mass="56871" checksum="37DA50EAB2BA5502" modified="2016-09-07" version="1">MDRHQRIVTQVASKVREYFIRKESFRINHGSTNSTRPSLKKRVVDISELRNVVKVDTASRTALVEPNVPMDRLVEATLPHGLVPPVVMEFPGITTGGGYAGTAGESSSFRHGFFDRTVNSVEMVLADGNVVKASEQENADLFRGAAGAVGTLGVATLIELQLIQAKRFVKTTYHPTRSIAEAVRDIRKQTEVPDNDYVDGILFSKDHGAIITGEMTDEIPADHKPQTFSDPWDPWFYLHVEERTRNASSPVIEYIPLAEYMFRYDRGGFWVGRSAFNYMSFPFNKVTRWFLDDFLHTRMLYRALHASGESNSYVVQDMALPYPNAEEFINYTDDKFGIWPLWLCPLKQSPQPTMHPHSKGALKDDQMLNIGLWGFGPRDRKQFLEKNRDLEKRLGELGGMKWLYAHTYYSEADFWKQFDREWHEELRKKYNATTLPGVHDKVHVDIEKLETLAKQDWGMRIRSIWPLGGFWGIWKSIQSGDYHISRKSTWRWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CNZ9</accession>
    <name>A0A177CNZ9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Spindle pole body-associated protein cut12 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_432975</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG09265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039630.1">
        <property type="nucleotide sequence ID" value="XM_018186232.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CNZ9"/>
    <dbReference type="STRING" id="1460663.A0A177CNZ9"/>
    <dbReference type="GeneID" id="28769718"/>
    <dbReference type="InParanoid" id="A0A177CNZ9"/>
    <dbReference type="OrthoDB" id="5383703at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021589">
        <property type="entry name" value="Cut12"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11500">
        <property type="entry name" value="Cut12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Spindle pole body-associated protein cut12" evidence="3">
        <location>
            <begin position="174"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="121"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="352"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="409"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="574"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="208"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="164"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="413"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="447"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="496"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="587"/>
            <end position="627"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF11500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAG09265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="635" mass="69124" checksum="E689E1C688AE00CC" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CP24</accession>
    <name>A0A177CP24_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Carbonic anhydrase</fullName>
            <ecNumber evidence="5">4.2.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Carbonate dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CC84DRAFT_1110537</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Reversible hydration of carbon dioxide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>hydrogencarbonate + H(+) = CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:10748"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="EC" id="4.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="4">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the beta-class carbonic anhydrase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.1" evidence="5"/>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG09285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039650.1">
        <property type="nucleotide sequence ID" value="XM_018175257.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CP24"/>
    <dbReference type="STRING" id="1460663.A0A177CP24"/>
    <dbReference type="GeneID" id="28758743"/>
    <dbReference type="InParanoid" id="A0A177CP24"/>
    <dbReference type="OrthoDB" id="10248475at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004089">
        <property type="term" value="F:carbonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03379">
        <property type="entry name" value="beta_CA_cladeD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1050.10">
        <property type="entry name" value="Carbonic anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001765">
        <property type="entry name" value="Carbonic_anhydrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036874">
        <property type="entry name" value="Carbonic_anhydrase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43175:SF3">
        <property type="entry name" value="CARBON DISULFIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43175">
        <property type="entry name" value="CARBONIC ANHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00484">
        <property type="entry name" value="Pro_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00947">
        <property type="entry name" value="Pro_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53056">
        <property type="entry name" value="beta-carbonic anhydrase, cab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="4">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR601765-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAG09285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="168" mass="18116" checksum="EC591653512738A1" modified="2016-09-07" version="1">MSSHVEQNLVEGNKAYAAAFTQGHLALPPSQKYAVLTCMDARIDPAAAFNIPLGAAHVIRNAGASARDAFRSLVISQQLLGTTEVLLVKHTGCGMLTFDNDTARGLVKKNKGEAAAKEVENIDFITFSELEEQVKDDVAWLKSKAVEEGVGVTGWIYEVETGQVRKVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CP44</accession>
    <name>A0A177CP44_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ubiquitin 3 binding protein But2 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1174006</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038912.1">
        <property type="nucleotide sequence ID" value="XM_018180069.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CP44"/>
    <dbReference type="STRING" id="1460663.A0A177CP44"/>
    <dbReference type="GeneID" id="28763555"/>
    <dbReference type="InParanoid" id="A0A177CP44"/>
    <dbReference type="OrthoDB" id="4657524at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018620">
        <property type="entry name" value="Ubiquitin3-bd_protein_But2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39613">
        <property type="entry name" value="ANCHORED CELL WALL PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G08960)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39613:SF1">
        <property type="entry name" value="ANCHORED CELL WALL PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G08960)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09792">
        <property type="entry name" value="But2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008058528" description="Ubiquitin 3 binding protein But2 C-terminal domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin 3 binding protein But2 C-terminal" evidence="2">
        <location>
            <begin position="23"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG08547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="208" mass="22810" checksum="649558896D472C84" modified="2016-09-07" version="1">MRAVILSVVFGLGVLADALYRDYPHLIIPLDAKAPDKAYGTVPTFHISNDNWTAANWDVPNNNATRCQLGFTINTDENRGAPWSLWGVNDDEAYLINIVALENDSIKPNTTFISLPKSGVTVATLAVKSSGDTNLTMVKELVCQKGQVASFLLQPADPLRQWDSGLSCVRLCQSVQTAGYRAMPCFSSSHTTVHIRHNVDRHNQGQRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CP64</accession>
    <name>A0A177CP64_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CC84DRAFT_433850</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG09313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039678.1">
        <property type="nucleotide sequence ID" value="XM_018186244.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CP64"/>
    <dbReference type="STRING" id="1460663.A0A177CP64"/>
    <dbReference type="GeneID" id="28769730"/>
    <dbReference type="InParanoid" id="A0A177CP64"/>
    <dbReference type="OrthoDB" id="7464126at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054471">
        <property type="entry name" value="GPIID_WHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF10">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22939">
        <property type="entry name" value="WHD_GPIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="4">
        <location>
            <begin position="273"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="domain" description="GPI inositol-deacylase winged helix" evidence="3">
        <location>
            <begin position="537"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="795"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="830"/>
            <end position="854"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAG09313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="894" mass="100006" checksum="4A274826EA2FD8B3" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CPM7</accession>
    <name>A0A177CPM7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CENP-V/GFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CC84DRAFT_586051</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfa family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039104.1">
        <property type="nucleotide sequence ID" value="XM_018186784.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CPM7"/>
    <dbReference type="GeneID" id="28770270"/>
    <dbReference type="InParanoid" id="A0A177CPM7"/>
    <dbReference type="OrthoDB" id="2993351at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016846">
        <property type="term" value="F:carbon-sulfur lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052355">
        <property type="entry name" value="CENP-V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006913">
        <property type="entry name" value="CENP-V/GFA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28620:SF1">
        <property type="entry name" value="CENP-V_GFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28620">
        <property type="entry name" value="CENTROMERE PROTEIN V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04828">
        <property type="entry name" value="GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51891">
        <property type="entry name" value="CENP_V_GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CENP-V/GFA" evidence="4">
        <location>
            <begin position="17"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAG08739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="137" mass="14999" checksum="5E016420407FD4E3" modified="2016-09-07" version="1">MSSAGIADTSDPPSAIYTGSCHCGSFTYTVQQSPPLDHPSCEVKECNCSMCARNGYLFITPAEKNVKFTNGEKDEFKKYTFGKHIFAHYFCGTCGVSCMAQSLDPNLWADIVAVNVRTLQDVDLKSLNVKLADGKRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CPN6</accession>
    <name>A0A177CPN6_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">protein disulfide-isomerase</fullName>
            <ecNumber evidence="3">5.3.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CC84DRAFT_1204093</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Catalyzes the rearrangement of -S-S- bonds in proteins.</text>
            <dbReference type="EC" id="5.3.4.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="5.3.4.1" evidence="3"/>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039205.1">
        <property type="nucleotide sequence ID" value="XM_018181880.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CPN6"/>
    <dbReference type="STRING" id="1460663.A0A177CPN6"/>
    <dbReference type="GeneID" id="28765366"/>
    <dbReference type="InParanoid" id="A0A177CPN6"/>
    <dbReference type="OrthoDB" id="10264505at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003756">
        <property type="term" value="F:protein disulfide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034976">
        <property type="term" value="P:response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03002">
        <property type="entry name" value="PDI_a_MPD1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02981">
        <property type="entry name" value="PDI_b_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057305">
        <property type="entry name" value="Thioredox_PDIA6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45815">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE A6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45815:SF3">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE A6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24541">
        <property type="entry name" value="Thioredox_PDIA6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00421">
        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008058471" description="protein disulfide-isomerase" evidence="8">
        <location>
            <begin position="21"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="9">
        <location>
            <begin position="12"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="241"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="259"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="273"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAG08840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="499" mass="53624" checksum="24B2D826F25791B9" modified="2016-09-07" version="1">MVRSTAIAAAVAALALQADAAGLYPKSSKVLQVTTADYDRLIAKSNYTSIVEFYAPWCGHCKNLQPAYERAAKSLEGIAKVAAVNCDEELNKPLCGKMGVQGFPTLKIVRPGKKPGKPTVEDYNGPREAKGIVEVVKDKVPNNVKRVTDAKLDEWLDENKDSAKAILFSEKGAISATLRTLAIDFAGLVPIAQIRKTESAAVEKYGITKFPALVLLKAGSDEPIKYDGAMEKAGMVEFLSQIAPPNPDCPPAKAKKDNKKKDKKDAKKESKFSKASASHKSSEASSAATSAADETLEEANKPTESPDASLKDEDTPEPIVISEVKPTIPVIADASGLQAACLNEKSKTCILAILPKDESAEAATTALASLASIHKKYDDLKSTLFPFIGVPSSNPIATSLLKELSLGSDDEVHLVATNGKRSWYKKYSGTAYGPIEVESWVDAIRMGDGKKEKLPESLLAAAEKEQVKEEKVPEQEPIKIEIEEVVEEPEAPIPEHGEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CPP5</accession>
    <name>A0A177CPP5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Aromatic compound dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CC84DRAFT_1204024</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(3+)</name>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the intradiol ring-cleavage dioxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039102.1">
        <property type="nucleotide sequence ID" value="XM_018181873.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CPP5"/>
    <dbReference type="STRING" id="1460663.A0A177CPP5"/>
    <dbReference type="GeneID" id="28765359"/>
    <dbReference type="InParanoid" id="A0A177CPP5"/>
    <dbReference type="OrthoDB" id="5238185at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018576">
        <property type="term" value="F:catechol 1,2-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009712">
        <property type="term" value="P:catechol-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.130.10">
        <property type="entry name" value="Aromatic compound dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007535">
        <property type="entry name" value="Catechol_dOase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000627">
        <property type="entry name" value="Intradiol_dOase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015889">
        <property type="entry name" value="Intradiol_dOase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050770">
        <property type="entry name" value="Intradiol_RC_Dioxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33711">
        <property type="entry name" value="DIOXYGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G02910)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33711:SF5">
        <property type="entry name" value="INTRADIOL RING-CLEAVAGE DIOXYGENASE PRCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00775">
        <property type="entry name" value="Dioxygenase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04444">
        <property type="entry name" value="Dioxygenase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49482">
        <property type="entry name" value="Aromatic compound dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Catechol dioxygenase N-terminal" evidence="8">
        <location>
            <begin position="37"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="Intradiol ring-cleavage dioxygenases" evidence="7">
        <location>
            <begin position="121"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAG08737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="331" mass="37438" checksum="80B2B1F3054F5FB2" modified="2016-09-07" version="1">MAANGTNGTNGAKSNTSKFDPNFTQNVINLMSAETKPRHREILTSLITHLHDFCREVELTQDEWIIGVNYVNAIGQAYKKNRNEAWRVCDILGVESLVDEINHTVVTDVEHKLTPTPSTILGPFWSPETPFRENGDSVVQDMPKDGSGELTFFHGVIRDVDTGKGIPGAVFDMWQASTNGKYDVFDPENQTRHNLRGKFKSDEEGKFWFYCLKPTEYAIDTSGPSADLLKIMGRHPWRPAHIHAMITHDDYIPVTVQLYPNDDQYLETDTVCAVKDDLLLDFKPVKDEKNGAVLDVEYEVRLLNKKYKPDASTLMGNANQDNFKDNIESKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CQC1</accession>
    <name>A0A177CQC1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1142416</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG09142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039507.1">
        <property type="nucleotide sequence ID" value="XM_018176367.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CQC1"/>
    <dbReference type="STRING" id="1460663.A0A177CQC1"/>
    <dbReference type="GeneID" id="28759853"/>
    <dbReference type="InParanoid" id="A0A177CQC1"/>
    <dbReference type="OrthoDB" id="5337308at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008058465" evidence="1">
        <location>
            <begin position="18"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG09142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="352" mass="39673" checksum="2202DDEEB2286D77" modified="2016-09-07" version="1">MVAVALLSAILGGPIAASPTNITRRWDKSATANDQIWSKAVCKGGEFVEAFTRNDEEAAKIFKPAANPPTMRNEWQGDLKEDLSKWGWEETDPHAEYFCNFETFWQYSTPYDALGLNKKPKYLGFPKHSSPDGGDNICYELWHGDKELDDDNEKRFVDQEYKVNDQEYSKTGANHKIAINHVGGVVTAQFRLSPAHAAEKNWGYKPQRTELPALRTSADLLWGLWYRDNPDVKNIRYFWAQNVQNIDTSRIAASALSIWGKELSGWPGATFDMDSDEGMALLGSPNAISFGYFLVSHKKELGNKKINKAQVFFGNENSRSPMDKRHPDLLFYVEDVPEETGKGTGGQHDDQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CTT0</accession>
    <name>A0A177CTT0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1256659</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041300.1">
        <property type="nucleotide sequence ID" value="XM_018184641.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CTT0"/>
    <dbReference type="GeneID" id="28768127"/>
    <dbReference type="InParanoid" id="A0A177CTT0"/>
    <dbReference type="OrthoDB" id="3788032at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="202"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="229"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="259"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG10935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="289" mass="31981" checksum="D706B7C54ABCF2AC" modified="2016-09-07" version="1">MPHMLQLPKQQQNDHHRVQLHSIHVASRADREHALPNPSKEGTDSPAPRCCVETQDSTRNDIDSIRNSGADKIFGWKEAAMDETDPPTKKALGSRDAHIAKSWPLYVYQDPGLRETPYCVEKTRHDIDHDDLGPSLYAQTGHQQAVLFPIPLPHPRTAIISACLLVATVSAFYEASKPDPPHHTGLDGHNDRFSSRLGLSQHIACSTASLFIFTAAAAVVYHLNAVHRFQDIFVLLGLIFGVVTGMAKYRDLRDAMLRAVPWGVIAALATSMVMHGAWESRTEVPARLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CU38</accession>
    <name>A0A177CU38_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1202884</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040797.1">
        <property type="nucleotide sequence ID" value="XM_018181796.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CU38"/>
    <dbReference type="GeneID" id="28765282"/>
    <dbReference type="InParanoid" id="A0A177CU38"/>
    <dbReference type="OrthoDB" id="21072at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="308"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="308"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG10432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="391" mass="45333" checksum="156BE9A911651F4A" modified="2016-09-07" version="1">MSAPAPRPPPRRPIFLEPWFQDMMKPGMPPILVSDFEDDPPVTVRYIQGNNDLDFKTVYTSIRTLSHHPGRGLLDTNNEDDPDPDFYIEKKCDPAFLEAFWKCAAYLCDYFADFLAFDTAHMQSVWFHLLDKLQEATILPHYFWISRMPFCEHSEDFVGDTNRLYVLISGLIAPTRIAPPSNILGTDYMNKDRRDDGVSGLKGWQQFLYKDSPGFFVPKSKRLYPMTAGTPTDRMVFEAHIPRGGLAIVDSHTKKLRELTEQVSRVRFAYNWYKARSDKRRENRAPTPEQKHSLSLIKRYTKRKEMIPDPKLPRAPRRHPDLVDPGFQNLKPGLERLNELTGAYKGKDIYQHPDDDDEKFPMLSLGYPEAPQNRTLQSRVDRAAYSEMYIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CU46</accession>
    <name>A0A177CU46_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Rhodanese-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_1213853</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040903.1">
        <property type="nucleotide sequence ID" value="XM_018182577.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CU46"/>
    <dbReference type="FunCoup" id="A0A177CU46">
        <property type="interactions" value="460"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CU46"/>
    <dbReference type="GeneID" id="28766063"/>
    <dbReference type="InParanoid" id="A0A177CU46"/>
    <dbReference type="OrthoDB" id="270167at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004792">
        <property type="term" value="F:thiosulfate-cyanide sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002143">
        <property type="term" value="P:tRNA wobble position uridine thiolation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01448">
        <property type="entry name" value="TST_Repeat_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01449">
        <property type="entry name" value="TST_Repeat_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.250.10:FF:000001">
        <property type="entry name" value="Sulfurtransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.250.10:FF:000033">
        <property type="entry name" value="Thiosulfate sulfurtransferase TUM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045078">
        <property type="entry name" value="TST/MPST-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11364:SF27">
        <property type="entry name" value="SULFURTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11364">
        <property type="entry name" value="THIOSULFATE SULFERTANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Rhodanese" evidence="3">
        <location>
            <begin position="54"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodanese" evidence="3">
        <location>
            <begin position="186"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAG10538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="309" mass="34233" checksum="B9FFC74F2E9E29A7" modified="2016-09-07" version="1">MSQYTLTSYIVTPAELDSALKKNVFSKLSTAPRIIPLCASWFLPNDDRTGIDTFNEARIPHARFFDLDEVKDQHSSYPHMLPSAKDFANAMGRLGIRKDDSVVVYDSKELGIFSAPRVAWTLQIFGHPNVHILNNFRTWVRDGFPTESGEPAVHERVEYPVPELDKSKVIAFEEVKEIVKDAGKEGAEEVQVLDARPAGRWAGTDPEPREGISSGHMPGSTNIATNYLLHAEDKTLLPAAELRQVFESLGVDPAKPIISSCGTGVTAAIVDTALTEAGYPQTNRRIYDGSWTEWAQRVKPTEGLIRKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CU59</accession>
    <name>A0A177CU59_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1256369</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040913.1">
        <property type="nucleotide sequence ID" value="XM_018184616.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CU59"/>
    <dbReference type="GeneID" id="28768102"/>
    <dbReference type="InParanoid" id="A0A177CU59"/>
    <dbReference type="OrthoDB" id="10628381at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="202"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="247"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="270"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG10548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="291" mass="31746" checksum="B954C815AA01693D" modified="2016-09-07" version="1">MVSPSAEKRAAQPKPEPTTAESVTEKQAPNKDKKDPSESTDAYRKFVAANAVITKNKQLAKAPAKAEAEPKTRLEVLYAQHIRAPKRAKAPQVTRKPVLELPKKVGTKAEDLFKQQTDNVDAEDSDAFTDADAQAKEEASKLTACISKGDRDAQLLTIGIDNSAGGASKKRNYKKFEIDEDTDSAKLAKKVMASFVFVDLDFKPKPVPHPHPHAKKMKMAWGKAASPRMTKEKGDMKPEHSDERTEHRARKKPARKTVPRTALDYACGGEDGEECGGGEEAGNEQEPDGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CU91</accession>
    <name>A0A177CU91_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphoesterase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1161423</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040847.1">
        <property type="nucleotide sequence ID" value="XM_018177733.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CU91"/>
    <dbReference type="STRING" id="1460663.A0A177CU91"/>
    <dbReference type="GeneID" id="28761219"/>
    <dbReference type="InParanoid" id="A0A177CU91"/>
    <dbReference type="OrthoDB" id="5135119at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009395">
        <property type="term" value="P:phospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.720.10:FF:000064">
        <property type="entry name" value="Probable acid phosphatase Pho610"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007312">
        <property type="entry name" value="Phosphoesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31956:SF15">
        <property type="entry name" value="ACID PHOSPHATASE PHOA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31956">
        <property type="entry name" value="NON-SPECIFIC PHOSPHOLIPASE C4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04185">
        <property type="entry name" value="Phosphoesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008058592" evidence="2">
        <location>
            <begin position="19"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG10482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="394" mass="43831" checksum="4FDF847C5858E9DD" modified="2016-09-07" version="1">MVSSLLLSVSLLASAAVAAPKQPSGGYKTSDWVTGKAFDRVAIIWLENTDYDLAIGDPSLKSLAKKGITLTNHFAVTHPSLPNYAAAISGDYYGINHDDMTAIPSNVSTIVDLLEAKKISWGAYQEDMPYTGFQGFDYKNQKTGANDYVRKHNPPVLYNSVVEQTSRLNQIKNLTLFYEDLKADALPQWMFITPNMTSDGHDSTVTVAGTWSKNFLEPLLNDKKFMKNTLVILTFDENHTYTQQNRIVGILLGDAVPKELVGTSDSNFYNHYSEIATVQANWGLDTLGRWDVGANVFDFVAKKTGDDVRQWSGKTPLSQMYWNVSYAGKLNNKNTSVPWPIPATKLKHNGRKVADVVKKTWGSLEKDSAYTTALEVPDGLHPESEFTRAQKTKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CUK1</accession>
    <name>A0A177CUK1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1213787</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040832.1">
        <property type="nucleotide sequence ID" value="XM_018182569.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CUK1"/>
    <dbReference type="STRING" id="1460663.A0A177CUK1"/>
    <dbReference type="GeneID" id="28766055"/>
    <dbReference type="InParanoid" id="A0A177CUK1"/>
    <dbReference type="OrthoDB" id="5344169at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11392">
        <property type="entry name" value="bHLH_ScPHO4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BHLH" evidence="2">
        <location>
            <begin position="554"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="220"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="377"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="585"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="648"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="225"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="333"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="438"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="594"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="649"/>
            <end position="671"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG10467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="671" mass="72178" checksum="3F344911B68B1A88" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CV82</accession>
    <name>A0A177CV82_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BRCT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1170344</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG11433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041798.1">
        <property type="nucleotide sequence ID" value="XM_018179852.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CV82"/>
    <dbReference type="GeneID" id="28763338"/>
    <dbReference type="InParanoid" id="A0A177CV82"/>
    <dbReference type="OrthoDB" id="427711at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRCT" evidence="2">
        <location>
            <begin position="275"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="219"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="99"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="220"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG11433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="375" mass="39997" checksum="1340B154E3150398" modified="2016-09-07" version="1">MSTPMSASKLDDDPELPPPSAQPVQQQKSRASALNPGNNSHARTSGVPRRDDRTVSHQARVAAHAAVDHSARSRMHTHHTPAIPSRTSTKPPPAPAPAPAATSQTAAKPSASCAHPPPLLTSGVASTARTFFDPWNSSSTGHQRAENRLSGSTSWRQSRSLKLAEQYKGGRGGGKRVADTVGAGSEDFGQDGRLANGGWQKGARGLRTGGQKSLAEFWGKSKASSTAKRSSQEKHAEDASWSESLSSTREINLHQEGTDRDAEPASDPQHLAKLPEKQIFRSLCFYINGSTMPAISDHKLKYVLNVHGASQSIALGRRTVTHVILGTTCGGGLAGSKLQKEIARTRGAAVKYVTVEWVLESIAAGKDYQNQGFRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CW49</accession>
    <name>A0A177CW49_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CC84DRAFT_1211413</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG11775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042140.1">
        <property type="nucleotide sequence ID" value="XM_018182377.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CW49"/>
    <dbReference type="STRING" id="1460663.A0A177CW49"/>
    <dbReference type="GeneID" id="28765863"/>
    <dbReference type="InParanoid" id="A0A177CW49"/>
    <dbReference type="OrthoDB" id="194139at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507:SF1">
        <property type="entry name" value="FI18259P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507">
        <property type="entry name" value="ZGC:174356"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008058657" evidence="6">
        <location>
            <begin position="27"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="126"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="166"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="190"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="255"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="299"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="338"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="389"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="424"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAG11775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="464" mass="50131" checksum="5ED9443D50B9B4AF" modified="2016-09-07" version="1">MTRTKYTVPLIYITSFLFLFGETVQPAPRIAIYEAIVCQQYYSSPSTGAGPHDCKAAPVQEELALLGGIERLSIIIPSVLAIPFAALADRYGHSLILAIAIFGVFLEDGWPFLVTWFPNVFPIRLIWLHFVFSCVGGGFTTIITLLHVIIVDVVSAEDRTRMFFRSRAAGVAASIVGYATSGLMMRVNDYLPWAVGLGSLVLGTVAAAMIPNQTVEAGRKPVGSSGRDAGWKAKIRRTAKALKDVATLLLGNKQVVAMLGLVFLCQLGFDAGPLMLAIYVSKRFGWSFSDASFLNSLEMSVELLMLVFFLPLLTATLPVRFQNLSPAMKDKNVAGWSLLALAVGQLCLGFAPVAAVAILGVVIIAMGAGQDSLLRSLATEMVPTRDISMIYSAITMLRAIGGSVSGPIYAWLYAVGLRQRQEVWIGLPYIVAGLLFLVALGLLMGLEVPEREGYEAIEEDEARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CW57</accession>
    <name>A0A177CW57_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">SURF6-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CC84DRAFT_1106623</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SURF6 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG11268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041633.1">
        <property type="nucleotide sequence ID" value="XM_018175149.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CW57"/>
    <dbReference type="FunCoup" id="A0A177CW57">
        <property type="interactions" value="300"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CW57"/>
    <dbReference type="GeneID" id="28758635"/>
    <dbReference type="InParanoid" id="A0A177CW57"/>
    <dbReference type="OrthoDB" id="444809at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029190">
        <property type="entry name" value="Rrp14/SURF6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029188">
        <property type="entry name" value="Rrp14_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007019">
        <property type="entry name" value="SURF6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14369">
        <property type="entry name" value="SURFEIT LOCUS PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14369:SF0">
        <property type="entry name" value="SURFEIT LOCUS PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15459">
        <property type="entry name" value="RRP14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04935">
        <property type="entry name" value="SURF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribosomal RNA-processing protein 14 N-terminal" evidence="6">
        <location>
            <begin position="8"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal RNA-processing protein 14/surfeit locus protein 6 C-terminal" evidence="5">
        <location>
            <begin position="314"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="40"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="85"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="139"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="172"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="182"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="196"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="233"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="279"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="342"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="386"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="423"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="445"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="507"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF15459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAG11268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="532" mass="59970" checksum="D2FCBF320A994A94" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CW88</accession>
    <name>A0A177CW88_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein Zds1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1200987</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG11824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042189.1">
        <property type="nucleotide sequence ID" value="XM_018181696.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CW88"/>
    <dbReference type="STRING" id="1460663.A0A177CW88"/>
    <dbReference type="GeneID" id="28765182"/>
    <dbReference type="InParanoid" id="A0A177CW88"/>
    <dbReference type="OrthoDB" id="5589766at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030010">
        <property type="term" value="P:establishment of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010971">
        <property type="term" value="P:positive regulation of G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040206">
        <property type="entry name" value="Zds1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013941">
        <property type="entry name" value="ZDS1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28089">
        <property type="entry name" value="PROTEIN ZDS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28089:SF1">
        <property type="entry name" value="PROTEIN ZDS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08632">
        <property type="entry name" value="Zds_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01327">
        <property type="entry name" value="Zds_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein Zds1 C-terminal" evidence="2">
        <location>
            <begin position="727"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="312"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="798"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="113"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="267"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="340"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="390"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="430"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="452"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="498"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="513"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="553"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="600"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="627"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="652"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="816"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="863"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="875"/>
            <end position="891"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG11824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="916" mass="102717" checksum="2CD59A9A77D9A971" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CWI2</accession>
    <name>A0A177CWI2_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RNA polymerase II subunit A C-terminal domain phosphatase</fullName>
            <ecNumber evidence="6">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CC84DRAFT_6237</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">This promotes the activity of RNA polymerase II.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4 6">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="6"/>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG11252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041617.1">
        <property type="nucleotide sequence ID" value="XM_018186930.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CWI2"/>
    <dbReference type="FunCoup" id="A0A177CWI2">
        <property type="interactions" value="804"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CWI2"/>
    <dbReference type="GeneID" id="28770416"/>
    <dbReference type="InParanoid" id="A0A177CWI2"/>
    <dbReference type="OrthoDB" id="10249888at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008420">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd17729">
        <property type="entry name" value="BRCT_CTDP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07521">
        <property type="entry name" value="HAD_FCP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039189">
        <property type="entry name" value="Fcp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004274">
        <property type="entry name" value="FCP1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011947">
        <property type="entry name" value="FCP1_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02250">
        <property type="entry name" value="FCP1_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23081">
        <property type="entry name" value="RNA POLYMERASE II CTD PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23081:SF36">
        <property type="entry name" value="RNA POLYMERASE II SUBUNIT A C-TERMINAL DOMAIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00533">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03031">
        <property type="entry name" value="NIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00577">
        <property type="entry name" value="CPDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50969">
        <property type="entry name" value="FCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FCP1 homology" evidence="9">
        <location>
            <begin position="164"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="8">
        <location>
            <begin position="532"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="429"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="646"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="687"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="444"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="646"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="692"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="704"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="781"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="799"/>
            <end position="811"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAG11252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="822" mass="92185" checksum="3179C955C77F32EC" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CWM8</accession>
    <name>A0A177CWM8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1170230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG11302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041667.1">
        <property type="nucleotide sequence ID" value="XM_018179843.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CWM8"/>
    <dbReference type="GeneID" id="28763329"/>
    <dbReference type="InParanoid" id="A0A177CWM8"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="269"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="269"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG11302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="292" mass="32771" checksum="8F832998B37D6342" modified="2016-09-07" version="1">MGCIIYHKYDTNRADEYGEFEYNPKDSQFEDFFFNPDTPGVVSTPIDQTPSTDYDSYYGYEGYCGGVEFNDHYGTPGPYRSPGFDIPGFYGSSEFYGSPGMYGGYEGMYDFYHSPGMCYVYDISVMYDMYGDYNSPAICQIQSSSNHPPATPRNGRLTSRPTSPSNDARSNLVSFPFRLPIITAIRICIYNISHTAATAQVSVRAIVANSTHPYPLRSLFRMPRTFICTLPRIKIVVECEEAETEDDSKAQFEPLKEEEETPLVFAGYEEPEHDQDPAEEVFGSASAGSCTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CXW8</accession>
    <name>A0A177CXW8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_65720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042431.1">
        <property type="nucleotide sequence ID" value="XM_018187038.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CXW8"/>
    <dbReference type="GeneID" id="28770524"/>
    <dbReference type="InParanoid" id="A0A177CXW8"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG12066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="157" mass="16757" checksum="91702F568A2B2C12" modified="2016-09-07" version="1">MRAATDSGRGKGAPSRQTGRPASAMTACIQRSQPSCQLRCEHCPFAKPRAKRAAHAVAAGDLAIAHARPHDAPILPARTSSGKLFELRACGALVREAKARCDSRKMHPGRCAHGAVVQHMALTSTWAQAPQRAAEHPSKTIDASARRNSNLRQNAKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CY01</accession>
    <name>A0A177CY01_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Amidohydrolase-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1159223</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG11772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042137.1">
        <property type="nucleotide sequence ID" value="XM_018177174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CY01"/>
    <dbReference type="FunCoup" id="A0A177CY01">
        <property type="interactions" value="16"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CY01"/>
    <dbReference type="GeneID" id="28760660"/>
    <dbReference type="InParanoid" id="A0A177CY01"/>
    <dbReference type="OrthoDB" id="5595695at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.520">
        <property type="entry name" value="Amidohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.90">
        <property type="entry name" value="Amidohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10910">
        <property type="entry name" value="Amidohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051781">
        <property type="entry name" value="Metallo-dep_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43135">
        <property type="entry name" value="ALPHA-D-RIBOSE 1-METHYLPHOSPHONATE 5-TRIPHOSPHATE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43135:SF3">
        <property type="entry name" value="ALPHA-D-RIBOSE 1-METHYLPHOSPHONATE 5-TRIPHOSPHATE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="1">
        <location>
            <begin position="53"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG11772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="419" mass="45660" checksum="37BB3C4C444C77A9" modified="2016-09-07" version="1">MTSFLIRDVQVFTGEDTIPNGYVHVSDGKIKAVGPMSAIPELSIPTHSRPGHTLLPGLIDAHIHADMANPTALPQALRFGVTTVCEMHNELANVVKLRKQAREPDTAAYKTAGQAATIENGWPIPVITAHDKSAETAAEIAKWPKLSCREDVVEYLDWMEAEMQPDYIKLMHESGTSMGWPLAKPSVGLQRIIVDEASKRGHLTVAHATSLQDTLEVLEAGVHGLTHTICDQPPTQELVDAYKRRNAWVNPTLATMGSLTGEGRELQDRFAHDPRVKGLIDESAVHNLCNCMGFAAQHGKVEYAYESVRMLKEAGVDILCGSDAAGPAVGTAFGLSMHQELYVYVHKIGMTPAEALRSATSLVAKRFKFADRGRLAEGLNADLLLVEGDPLADINATLNIRGVWREGRMCSVHQGKLEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CYR7</accession>
    <name>A0A177CYR7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_1254337</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG11980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042345.1">
        <property type="nucleotide sequence ID" value="XM_018184453.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CYR7"/>
    <dbReference type="GeneID" id="28767939"/>
    <dbReference type="InParanoid" id="A0A177CYR7"/>
    <dbReference type="OrthoDB" id="3786778at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008058766" evidence="3">
        <location>
            <begin position="21"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="219"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="244"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="61"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAG11980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="286" mass="29915" checksum="69D4B5DF47B27065" modified="2016-09-07" version="1">MQLPTLTLLTLSTLATLSTSTPVDNGIPISNVLTALGAAKPVTPSTVAKPVTPSAVAKPVTPSAAPKPATLPATTKPSTLPAVGAAGPHISSLDDIALLGATGSVASTPAILTYLRSTTTEVKKHTLNINNTLASYNRLDLNFLTKRASSIIQIRSEVTVICYSLTQLNTASIGRWTDSIGDLASVRAQLLAAVQELVWEIVFTLRGALTIWELLGSQVLVLLVTFGQLFCILNVWIDGFLKLALGLLNAQIGILTSVFAGVLSYVVDVAGGLFTQVTKLLTCLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CZY4</accession>
    <name>A0A177CZY4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="19">GPI anchored CFEM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CC84DRAFT_1135284</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RBT5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042902.1">
        <property type="nucleotide sequence ID" value="XM_018176057.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CZY4"/>
    <dbReference type="STRING" id="1460663.A0A177CZY4"/>
    <dbReference type="GeneID" id="28759543"/>
    <dbReference type="InParanoid" id="A0A177CZY4"/>
    <dbReference type="OrthoDB" id="3767534at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051735">
        <property type="entry name" value="CFEM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008427">
        <property type="entry name" value="Extracellular_membr_CFEM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37928">
        <property type="entry name" value="CFEM DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G14090)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37928:SF2">
        <property type="entry name" value="GPI ANCHORED CFEM DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G10580)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05730">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00747">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52012">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="6 15" id="KW-0349">Heme</keyword>
    <keyword evidence="10 15" id="KW-0408">Iron</keyword>
    <keyword evidence="14" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="9 17" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008058811" evidence="17">
        <location>
            <begin position="19"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="CFEM" evidence="18">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="98"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="153"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="15">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS52012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="OAG12537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="192" mass="18472" checksum="733B5CC905708DF2" modified="2016-09-07" version="1">MKTFVPALLVALAGVASAQLADLPQCSLQCFLTALGSDGCSELTDFKCHCEKSDALLASVTPCVQGACTADEQAEVIKGVENTCASAGVTISVPAPSATAAPESSSAAPESSAEASSTEAASSSAAPSSYEVPASTSAAASSSVSAVPLPSANGTVPSSTPAPTQSEFPGAASRIGAAAGLVGAAAFAVFAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177D083</accession>
    <name>A0A177D083_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 11">Adenosylhomocysteinase</fullName>
            <ecNumber evidence="7 11">3.13.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CC84DRAFT_1109027</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Adenosylhomocysteine is a competitive inhibitor of S-adenosyl-L-methionine-dependent methyl transferase reactions; therefore adenosylhomocysteinase may play a key role in the control of methylations via regulation of the intracellular concentration of adenosylhomocysteine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 11">
            <text>S-adenosyl-L-homocysteine + H2O = L-homocysteine + adenosine</text>
            <dbReference type="Rhea" id="RHEA:21708"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16335"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
            <dbReference type="EC" id="3.13.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10 11">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
        <text evidence="10 11">Binds 1 NAD(+) per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Amino-acid biosynthesis; L-homocysteine biosynthesis; L-homocysteine from S-adenosyl-L-homocysteine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the adenosylhomocysteinase family.</text>
    </comment>
    <dbReference type="EC" id="3.13.2.1" evidence="7 11"/>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042905.1">
        <property type="nucleotide sequence ID" value="XM_018175214.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177D083"/>
    <dbReference type="FunCoup" id="A0A177D083">
        <property type="interactions" value="959"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177D083"/>
    <dbReference type="GeneID" id="28758700"/>
    <dbReference type="InParanoid" id="A0A177D083"/>
    <dbReference type="OrthoDB" id="10007170at2759"/>
    <dbReference type="UniPathway" id="UPA00314">
        <property type="reaction ID" value="UER00076"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004013">
        <property type="term" value="F:adenosylhomocysteinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006656">
        <property type="term" value="P:phosphatidylcholine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033353">
        <property type="term" value="P:S-adenosylmethionine cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006641">
        <property type="term" value="P:triglyceride metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00401">
        <property type="entry name" value="SAHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1480:FF:000004">
        <property type="entry name" value="Adenosylhomocysteinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000004">
        <property type="entry name" value="Adenosylhomocysteinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1480">
        <property type="entry name" value="Adenosylhomocysteinase-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00563">
        <property type="entry name" value="AdoHcyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042172">
        <property type="entry name" value="Adenosylhomocyst_ase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000043">
        <property type="entry name" value="Adenosylhomocysteinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015878">
        <property type="entry name" value="Ado_hCys_hydrolase_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020082">
        <property type="entry name" value="S-Ado-L-homoCys_hydrolase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00936">
        <property type="entry name" value="ahcY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004005">
        <property type="entry name" value="PRK05476.2-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23420">
        <property type="entry name" value="ADENOSYLHOMOCYSTEINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23420:SF0">
        <property type="entry name" value="ADENOSYLHOMOCYSTEINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05221">
        <property type="entry name" value="AdoHcyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00670">
        <property type="entry name" value="AdoHcyase_NAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001109">
        <property type="entry name" value="Ad_hcy_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00996">
        <property type="entry name" value="AdoHcyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00997">
        <property type="entry name" value="AdoHcyase_NAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00738">
        <property type="entry name" value="ADOHCYASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00739">
        <property type="entry name" value="ADOHCYASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 10 11" id="KW-0520">NAD</keyword>
    <keyword evidence="4 11" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S-adenosyl-L-homocysteine hydrolase NAD binding" evidence="13">
        <location>
            <begin position="197"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="161"/>
            <end position="163"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="228"/>
            <end position="233"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="249"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="254"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="305"/>
            <end position="307"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="352"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="359"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00034527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR001109-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001109-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OAG12540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="452" mass="49551" checksum="ECB81843350C8EB8" modified="2016-09-07" version="1">MSGQPAHTFKVADISLAAFGRREIELAENEMPGLMQTRARYAGEQPLKGARIAGCLHMTIQTAVLIETLKELGAELTWTSCNIFSTQDHAAAAIAAAGVPVFAWKGETEEEYNWCLEQQLTAFKDDKRLNLILDDGGDLTALVHKKYPEMLKDCYGVSEETTTGVHHLYRMLKNKEHGLLVPAINVNDSVTKSKFDNLYGCRESLVDGIKRATDVMIAGKVAVVAGYGDVGKGCADALRSMGARVLVTEIDPINALQAAVSGYQVTTMEKAAPQGQIFVTTTGCRDILVGKHFEVMPEDAIVCNIGHFDIEIDVAWLRANAESVSNIKPQVDRFLMKNGRHIILLADGRLVNLGCATGHSSFVMSCSFTNQVLAQIYLYKAGDDEFAKKFIEFGNSGKLEIGVYTLPKQLDEQVANLHLAHVNAELSVLTDVQAEYLSLPKQGPFKSDIYRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177D093</accession>
    <name>A0A177D093_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">MAP kinase kinase kinase</fullName>
            <ecNumber evidence="11">2.7.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CC84DRAFT_1109071</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Kinase involved in a signal transduction pathway that is activated by changes in the osmolarity of the extracellular environment. Activates the PBS2 MAP kinase kinase by phosphorylation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:17990"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:46609"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="10">Interacts with by SSK1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.-" evidence="11"/>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042925.1">
        <property type="nucleotide sequence ID" value="XM_018175215.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A177D093">
        <property type="interactions" value="324"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177D093"/>
    <dbReference type="GeneID" id="28758701"/>
    <dbReference type="InParanoid" id="A0A177D093"/>
    <dbReference type="OrthoDB" id="1043025at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004707">
        <property type="term" value="F:MAP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004709">
        <property type="term" value="F:MAP kinase kinase kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038066">
        <property type="term" value="P:p38MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051403">
        <property type="term" value="P:stress-activated MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06626">
        <property type="entry name" value="STKc_MEKK4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000482">
        <property type="entry name" value="MAP kinase kinase kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050538">
        <property type="entry name" value="MAP_kinase_kinase_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017240">
        <property type="entry name" value="MAPKKK_Ssk2/Ssk22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045801">
        <property type="entry name" value="MEKK4_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016">
        <property type="entry name" value="MAP KINASE KINASE KINASE SSK2-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016:SF32">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19431">
        <property type="entry name" value="MEKK4_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037579">
        <property type="entry name" value="MAPKKK_SSK22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 11 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 11" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="1049"/>
            <end position="1317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="87"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="176"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1327"/>
            <end position="1353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="40"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="103"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="139"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1327"/>
            <end position="1345"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="1078"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00056158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00065095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR037579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OAG12560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="1353" mass="152264" checksum="E4878A9971A5D407" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BTS7</accession>
    <name>A0A177BTS7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ENTH-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1169943</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441564">
        <property type="protein sequence ID" value="OAF98813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029179.1">
        <property type="nucleotide sequence ID" value="XM_018179797.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BTS7"/>
    <dbReference type="STRING" id="1460663.A0A177BTS7"/>
    <dbReference type="GeneID" id="28763283"/>
    <dbReference type="InParanoid" id="A0A177BTS7"/>
    <dbReference type="OrthoDB" id="4033880at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030125">
        <property type="term" value="C:clathrin vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006895">
        <property type="term" value="P:Golgi to endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16992">
        <property type="entry name" value="ENTH_Ent3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.90:FF:000006">
        <property type="entry name" value="Clathrin interactor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013809">
        <property type="entry name" value="ENTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12276:SF45">
        <property type="entry name" value="CLATHRIN INTERACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12276">
        <property type="entry name" value="EPSIN/ENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01417">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00273">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50942">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ENTH" evidence="2">
        <location>
            <begin position="27"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="218"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="453"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="236"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="261"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="305"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="315"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="337"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="347"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="485"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="498"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAF98813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="509" mass="53532" checksum="37A675D4C7212190" modified="2016-09-07" version="1">MDFASLKDQVSNLTLYDLKAGVRKVQNAVMNFTEMEAKVREATNNEPWGASSTLMQEIANATFNYQLLNEIMPMIYKRFTEKAAEEWRQIYKALQLLEFLIKNGSERVIDDARSHVSLLKMLRQFHFIDQNGKDQGINVRNRAKELAELLSDVDRIRSERKKARANRNKFGGVEGGMGMGGFSSGGGSGSRYGGFGSESANADYGGYSGGVYGDGGGFGGNESGFQDTQQRRDKFEEYDEGDEAESSAPPPRRSQPSATQVRKETKKEEPKPKAPEPVVDLLAWDDEPAPASSSAGKQPVAANDDFGDDDDFDDFQSAAPSAPAAKSTAASFIAPPASTSTIGASTQFAAPQPQSAAQNNNLNDLFATVSPPPASNNFASPAVATPASATSSMNQPYRPAGYQATGPNYFTSVPKPSIASTPSVASPGIGGKIGSGAPKQAGGDAFASLLGGAGPKKAATPTQRVTMADMAKQKTSQGLWGAPASGQSTPTSQPQGGAKPGGALGDLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BU94</accession>
    <name>A0A177BU94_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1210676</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441564">
        <property type="protein sequence ID" value="OAF98834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029200.1">
        <property type="nucleotide sequence ID" value="XM_018182304.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BU94"/>
    <dbReference type="GeneID" id="28765790"/>
    <dbReference type="InParanoid" id="A0A177BU94"/>
    <dbReference type="OrthoDB" id="4840564at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAF98834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="164" mass="18694" checksum="2CC0B72FEAE93241" modified="2016-09-07" version="1">MPSNNKRRKRRFRQLRLHVTDGNELILERVFKKSPRPAVPYEADPELFNQLPFYELSEFELAIALRPPFPVLRLPEELVLKILTNTVDIGYQRAQRPPSGKMYSVPLSLCAVCRAFRRLAYPLLFYYMGIKLSGEDISSVSGGSGLKASTPPLWVSHTSQMSIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BUC4</accession>
    <name>A0A177BUC4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1169759</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441563">
        <property type="protein sequence ID" value="OAF99053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029419.1">
        <property type="nucleotide sequence ID" value="XM_018179749.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BUC4"/>
    <dbReference type="STRING" id="1460663.A0A177BUC4"/>
    <dbReference type="GeneID" id="28763235"/>
    <dbReference type="InParanoid" id="A0A177BUC4"/>
    <dbReference type="OrthoDB" id="415532at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025340">
        <property type="entry name" value="DUF4246"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049192">
        <property type="entry name" value="DUF4246_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049207">
        <property type="entry name" value="DUF4246_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33119:SF1">
        <property type="entry name" value="FE2OG DIOXYGENASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33119">
        <property type="entry name" value="IFI3P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14033">
        <property type="entry name" value="DUF4246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21666">
        <property type="entry name" value="DUF4246_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4246" evidence="2">
        <location>
            <begin position="20"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4246" evidence="1">
        <location>
            <begin position="103"/>
            <end position="561"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAF99053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="626" mass="71609" checksum="CD3A9B592B544B15" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BUD3</accession>
    <name>A0A177BUD3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1264612</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441563">
        <property type="protein sequence ID" value="OAF99063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029429.1">
        <property type="nucleotide sequence ID" value="XM_018185320.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BUD3"/>
    <dbReference type="GeneID" id="28768806"/>
    <dbReference type="InParanoid" id="A0A177BUD3"/>
    <dbReference type="OrthoDB" id="5418036at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAF99063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="219" mass="23924" checksum="F3D77D69C260F041" modified="2016-09-07" version="1">MMASASEESPRITVEIVFDRLSHSFSQPSPPILTLTLTSHAKTPLTLFTWGTPFSLPRALTSNGFVITDTSSGQNVKTSLMQVQRTPLKRTRGSPDEQYFLTLQPESPVHLSTGFGRGGGGVKPQPKSVVERGLEVDANGNEVNLRRSKSATGVDGLEPGRKYEIGLNTDLLDIIRWAPAEKEDILVEGTGEGSYVQDYEWNKGSLNFSVRQSTLSVET</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BUT2</accession>
    <name>A0A177BUT2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_1131896</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441563">
        <property type="protein sequence ID" value="OAF99064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029430.1">
        <property type="nucleotide sequence ID" value="XM_018175917.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BUT2"/>
    <dbReference type="STRING" id="1460663.A0A177BUT2"/>
    <dbReference type="GeneID" id="28759403"/>
    <dbReference type="InParanoid" id="A0A177BUT2"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF166">
        <property type="entry name" value="CYTOCHROME P450 12A4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0349">Heme</keyword>
    <keyword evidence="4 5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="497"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAF99064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="565" mass="64379" checksum="133F94D5FCDDB8C7" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BW02</accession>
    <name>A0A177BW02_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Phospholipid-transporting ATPase</fullName>
            <ecNumber evidence="19">7.6.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">CC84DRAFT_1264416</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23 24">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13 19">
            <text>ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.</text>
            <dbReference type="EC" id="7.6.2.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-L-serine(out) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phospho-L-serine(in) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38567"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:38568"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66132"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:66133"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 18">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
            <location evidence="2">trans-Golgi network membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="19">Membrane</location>
            <topology evidence="19">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 19">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.1" evidence="19"/>
    <dbReference type="EMBL" id="KV441562">
        <property type="protein sequence ID" value="OAF99474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029840.1">
        <property type="nucleotide sequence ID" value="XM_018185309.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A177BW02">
        <property type="interactions" value="309"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177BW02"/>
    <dbReference type="GeneID" id="28768795"/>
    <dbReference type="InParanoid" id="A0A177BW02"/>
    <dbReference type="OrthoDB" id="377733at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990530">
        <property type="term" value="C:Cdc50p-Drs2p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140345">
        <property type="term" value="F:phosphatidylcholine flippase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090555">
        <property type="term" value="F:phosphatidylethanolamine flippase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070273">
        <property type="term" value="F:phosphatidylinositol-4-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140346">
        <property type="term" value="F:phosphatidylserine flippase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090556">
        <property type="term" value="F:phosphatidylserine floppase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006892">
        <property type="term" value="P:post-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd02073">
        <property type="entry name" value="P-type_ATPase_APLT_Dnf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000026">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000047">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000010">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000001">
        <property type="entry name" value="Phospholipid-transporting ATPase IC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006539">
        <property type="entry name" value="P-type_ATPase_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032631">
        <property type="entry name" value="P-type_ATPase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032630">
        <property type="entry name" value="P_typ_ATPase_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01652">
        <property type="entry name" value="ATPase-Plipid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092:SF150">
        <property type="entry name" value="PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092">
        <property type="entry name" value="PROBABLE PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16212">
        <property type="entry name" value="PhoLip_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16209">
        <property type="entry name" value="PhoLip_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 17 19" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 18 19" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 17 19" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 19" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="493"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="541"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1093"/>
            <end position="1115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1136"/>
            <end position="1160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1172"/>
            <end position="1189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1201"/>
            <end position="1221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1246"/>
            <end position="1263"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase N-terminal" evidence="21">
        <location>
            <begin position="228"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase C-terminal" evidence="22">
        <location>
            <begin position="1022"/>
            <end position="1274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="181"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="38"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="active site" description="4-aspartylphosphate intermediate" evidence="16">
        <location>
            <position position="605"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="605"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="605"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="606"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="607"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="607"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="699"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="740"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="763"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="796"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="877"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="878"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="879"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="970"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="976"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="996"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="999"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="1000"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="1000"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00051303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU362033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF16209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF16212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="OAF99474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="1349" mass="150935" checksum="1B551956E280A69C" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BWV6</accession>
    <name>A0A177BWV6_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CC84DRAFT_1169964</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KV441564">
        <property type="protein sequence ID" value="OAF98846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029212.1">
        <property type="nucleotide sequence ID" value="XM_018179802.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BWV6"/>
    <dbReference type="STRING" id="1460663.A0A177BWV6"/>
    <dbReference type="GeneID" id="28763288"/>
    <dbReference type="InParanoid" id="A0A177BWV6"/>
    <dbReference type="OrthoDB" id="1695362at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18870">
        <property type="entry name" value="NUDIX_AcylCoAdiphos_Nudt19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039121">
        <property type="entry name" value="NUDT19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12318:SF0">
        <property type="entry name" value="ACYL-COENZYME A DIPHOSPHATASE NUDT19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12318">
        <property type="entry name" value="TESTOSTERONE-REGULATED PROTEIN RP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0464">Manganese</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="8">
        <location>
            <begin position="19"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAF98846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="367" mass="39786" checksum="93C7F0E4F9DB1D0F" modified="2016-09-07" version="1">MSSPADHKPLDKPPKTPPMPVPSASVLVISPTNQVLLLHRVRTASAFSSAHVFPGGAISPEHDGPIPNITDTNPNQPAYRLAAIRETFEESGILLAKKNGKLFTDIGDAEREEGRKAVHAGTTLFADLLSKWGCEPDVEGLIPFTRWITPPNVKKRFSTQMYIYFLPLGSTLPGNSKSQASGDAARLDDVEAADIVIPHPTHDGGIEHTAARFLPPNKWINLANQNRIILFPPQYFLAWHLAPFLAPTVTSPSSPSPSIAELQAERDRLTAFLQSEAGDEFSKAIISPVALGKGDYGEDKQDGVGGVTKDTAVLRLDYPGPELDKAGVKGTMTKWVVTTKFKKEGPRDVRVVERGRILGKDGKASRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BX55</accession>
    <name>A0A177BX55_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Acetyl-CoA acetyltransferas-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CC84DRAFT_1264477</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441563">
        <property type="protein sequence ID" value="OAF98899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029265.1">
        <property type="nucleotide sequence ID" value="XM_018185312.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BX55"/>
    <dbReference type="STRING" id="1460663.A0A177BX55"/>
    <dbReference type="GeneID" id="28768798"/>
    <dbReference type="InParanoid" id="A0A177BX55"/>
    <dbReference type="OrthoDB" id="435240at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040771">
        <property type="entry name" value="TLP1_add_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18919">
        <property type="entry name" value="ACETYL-COA C-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18919:SF139">
        <property type="entry name" value="THIOLASE-LIKE PROTEIN TYPE 1 ADDITIONAL C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18313">
        <property type="entry name" value="TLP1_add_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase-like protein type 1 additional C-terminal" evidence="5">
        <location>
            <begin position="421"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="408"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF18313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAF98899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="512" mass="55240" checksum="9BDEADB399187DE2" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BX68</accession>
    <name>A0A177BX68_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1231370</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441560">
        <property type="protein sequence ID" value="OAG00013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030378.1">
        <property type="nucleotide sequence ID" value="XM_018183722.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BX68"/>
    <dbReference type="STRING" id="1460663.A0A177BX68"/>
    <dbReference type="GeneID" id="28767208"/>
    <dbReference type="InParanoid" id="A0A177BX68"/>
    <dbReference type="OrthoDB" id="542013at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG00013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="114" mass="12893" checksum="C42FDC8F9EBC2900" modified="2016-09-07" version="1" fragment="single">MGPDAELYIPEGAKTSEILGDPKRKDIVSRYALSKFMVHHCYHQLAASLRNSPTQDRSCVIFNMINLGWCETELSRTKPRPITERLSFAVMVWSAEKESRSYIHALAAGRESHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BX77</accession>
    <name>A0A177BX77_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1169440</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441562">
        <property type="protein sequence ID" value="OAF99301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029667.1">
        <property type="nucleotide sequence ID" value="XM_018179661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BX77"/>
    <dbReference type="GeneID" id="28763147"/>
    <dbReference type="InParanoid" id="A0A177BX77"/>
    <dbReference type="OrthoDB" id="5378430at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAF99301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="91" mass="9924" checksum="39CD7221DA78AA8B" modified="2016-09-07" version="1">MEDAVGVVMCRTCSLSPGGIIEKTLGAKTLELEPIAEQALRMTSNMLAFISVTQSWKSWIQPNNLDAYTGFLTMPSLFIAALQWKTGAKTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BXG4</accession>
    <name>A0A177BXG4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_1191042</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441561">
        <property type="protein sequence ID" value="OAF99650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030016.1">
        <property type="nucleotide sequence ID" value="XM_018181160.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BXG4"/>
    <dbReference type="STRING" id="1460663.A0A177BXG4"/>
    <dbReference type="GeneID" id="28764646"/>
    <dbReference type="InParanoid" id="A0A177BXG4"/>
    <dbReference type="OrthoDB" id="4525710at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF25">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="9"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="48"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="52"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAF99650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="516" mass="57552" checksum="1D9D7C10CD8A139E" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BYE1</accession>
    <name>A0A177BYE1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1210288</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441562">
        <property type="protein sequence ID" value="OAF99426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029792.1">
        <property type="nucleotide sequence ID" value="XM_018182281.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BYE1"/>
    <dbReference type="STRING" id="1460663.A0A177BYE1"/>
    <dbReference type="GeneID" id="28765767"/>
    <dbReference type="InParanoid" id="A0A177BYE1"/>
    <dbReference type="OrthoDB" id="10267950at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003877">
        <property type="term" value="F:ATP:ADP adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009163">
        <property type="entry name" value="Ap4A_phos1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043171">
        <property type="entry name" value="Ap4A_phos1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045759">
        <property type="entry name" value="Ap4A_phos1/2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019200">
        <property type="entry name" value="ATP_adenylylTrfase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38420">
        <property type="entry name" value="AP-4-A PHOSPHORYLASE II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38420:SF1">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_5G14690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19327">
        <property type="entry name" value="Ap4A_phos_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09830">
        <property type="entry name" value="ATP_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ap4A phosphorylase 1/2 N-terminal" evidence="2">
        <location>
            <begin position="81"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="ATP adenylyltransferase C-terminal" evidence="1">
        <location>
            <begin position="184"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAF99426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="294" mass="32104" checksum="2C499C40FAE8528A" modified="2016-09-07" version="1">MTRPTTIPPKEAILSTFDSLVAAGTISFGPYRTIKYDAGGYPLEFRVCPAFSRKPHTIGAKLDPIYTNLQQWGPGSDLFLSDPRMKLAQLNGTHDLAFNMFCTDRPQFLILTLDSYARQSELLDAADFQAALDMLHIPGVGSELYVIFNGGEEAGCSRVHKHLQGLRGPPPAFSNFVQEGLRASVPFQFFAHQFSSGFASVRGEQMASVYAGLISKAKDALGLPESASVVPHGMFMWKDWLVVIPRRKSGIEDTRASAATAGMLGSVWLSEEGPVEDWVRLGLREVLEGLGVPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BYG1</accession>
    <name>A0A177BYG1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10 11">Endo-1,4-beta-xylanase</fullName>
            <ecNumber evidence="4 10 11">3.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CC84DRAFT_1044513</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10 11">
            <text>Endohydrolysis of (1-&gt;4)-beta-D-xylosidic linkages in xylans.</text>
            <dbReference type="EC" id="3.2.1.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 10 11">Glycan degradation; xylan degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10 11">Belongs to the glycosyl hydrolase 11 (cellulase G) family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.8" evidence="4 10 11"/>
    <dbReference type="EMBL" id="KV441562">
        <property type="protein sequence ID" value="OAF99369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029735.1">
        <property type="nucleotide sequence ID" value="XM_018173401.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BYG1"/>
    <dbReference type="GeneID" id="28756887"/>
    <dbReference type="InParanoid" id="A0A177BYG1"/>
    <dbReference type="OrthoDB" id="2115822at2759"/>
    <dbReference type="UniPathway" id="UPA00114"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031176">
        <property type="term" value="F:endo-1,4-beta-xylanase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.180:FF:000001">
        <property type="entry name" value="Endo-1,4-beta-xylanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013319">
        <property type="entry name" value="GH11/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018208">
        <property type="entry name" value="GH11_AS_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033119">
        <property type="entry name" value="GH11_AS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033123">
        <property type="entry name" value="GH11_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001137">
        <property type="entry name" value="Glyco_hydro_11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46828">
        <property type="entry name" value="ENDO-1,4-BETA-XYLANASE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46828:SF2">
        <property type="entry name" value="ENDO-1,4-BETA-XYLANASE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00457">
        <property type="entry name" value="Glyco_hydro_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00911">
        <property type="entry name" value="GLHYDRLASE11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00776">
        <property type="entry name" value="GH11_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00777">
        <property type="entry name" value="GH11_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51761">
        <property type="entry name" value="GH11_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10 11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8 10 11" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 10 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 10 11" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="5 10 11" id="KW-0858">Xylan degradation</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008057462" description="Endo-1,4-beta-xylanase" evidence="12">
        <location>
            <begin position="20"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="GH11" evidence="13">
        <location>
            <begin position="35"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="10">
        <location>
            <position position="120"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10">
        <location>
            <position position="211"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OAF99369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="225" mass="24267" checksum="603201F0D0F5A2F2" modified="2016-09-07" version="1" fragment="single">MVAFSSIFLALGTAASVLTSPVNVTSPFNLLERAVATSPGTGTHDGYFYSFWTDGKGSVNYNNEAGGKYSVSWNNVNNFVAGKGWKPGAARTVTYSGTWNAANVNSYISLYGWTRNPLVEYYIVETYGSYNPASAAQKKGTITTDGGTYDILQTTRYNQPSIEGTSTFPQFWSVRQQKRVGGSINVGAHFNAWTQYGLKLGSHDYQILATEGYQSSGSASITVSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C0E6</accession>
    <name>A0A177C0E6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1168394</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441559">
        <property type="protein sequence ID" value="OAG00278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030643.1">
        <property type="nucleotide sequence ID" value="XM_018179388.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C0E6"/>
    <dbReference type="GeneID" id="28762874"/>
    <dbReference type="InParanoid" id="A0A177C0E6"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG00278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="58" mass="6146" checksum="8A58D5B13865D7EC" modified="2016-09-07" version="1">MPPSQFRPLLHPPPPRLLPTLGLLQHRMVPSASASVSAAYSSTPLAPPVLFLEAVPPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C2K1</accession>
    <name>A0A177C2K1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative Sterigmatocystin 8-O-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CC84DRAFT_1251739</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441556">
        <property type="protein sequence ID" value="OAG01873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032238.1">
        <property type="nucleotide sequence ID" value="XM_018184337.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C2K1"/>
    <dbReference type="STRING" id="1460663.A0A177C2K1"/>
    <dbReference type="GeneID" id="28767823"/>
    <dbReference type="InParanoid" id="A0A177C2K1"/>
    <dbReference type="OrthoDB" id="1606438at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016461">
        <property type="entry name" value="COMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001077">
        <property type="entry name" value="COMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712:SF12">
        <property type="entry name" value="STERIGMATOCYSTIN 8-O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00891">
        <property type="entry name" value="Methyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51683">
        <property type="entry name" value="SAM_OMT_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="O-methyltransferase C-terminal" evidence="4">
        <location>
            <begin position="174"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAG01873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="392" mass="43800" checksum="E121B4DED483E37C" modified="2016-09-07" version="1">MTSRESFSRIVQLARTISESVDKIEEVLVAEGIESPSFDEDATFNIPLKLSPQHDAVLDATAELHDLLLEPLNLIHRHGGDIARDTPLTTDMTARLLRHAMTMRIFRETSPGIVAHTAASRTLHKSAANDWLQAGTTEMWPAAVKTIDALKKWPASGEPNETGYSLANDTSETIYQIFSKDMERASRWARGMQIFAERPQFSLAYTTDYYDWESLGKAHVVDVGGSSGHVSLALARKFSNLSLTVQDMEQLVANATVPGDVQGRVKFMAHDIFSPQPVKNADVYYLRWILHNWSDKYCNLILNALLPALKPGARVIIHESLIPEPGTTAMWKEKNLRATDLNMAGAFNAKERTKVEYESLFKKVDPAFTLRNVVEPKGSALQMVEFLWEGTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C2R1</accession>
    <name>A0A177C2R1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Fungal trichothecene efflux pump</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_1262086</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441556">
        <property type="protein sequence ID" value="OAG02074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032439.1">
        <property type="nucleotide sequence ID" value="XM_018185126.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C2R1"/>
    <dbReference type="GeneID" id="28768612"/>
    <dbReference type="InParanoid" id="A0A177C2R1"/>
    <dbReference type="OrthoDB" id="4161376at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06179">
        <property type="entry name" value="MFS_TRI12_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010573">
        <property type="entry name" value="MFS_Str1/Tri12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053791">
        <property type="entry name" value="MFS_Tri12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF109">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06609">
        <property type="entry name" value="TRI12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="57"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="95"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="125"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="182"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="211"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="255"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="289"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="329"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="364"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="395"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="420"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="451"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="543"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="59"/>
            <end position="566"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAG02074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="595" mass="63442" checksum="DAEB991F90B5925F" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C386</accession>
    <name>A0A177C386_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FHA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1190290</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441558">
        <property type="protein sequence ID" value="OAG01130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031495.1">
        <property type="nucleotide sequence ID" value="XM_018181108.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C386"/>
    <dbReference type="FunCoup" id="A0A177C386">
        <property type="interactions" value="392"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177C386"/>
    <dbReference type="GeneID" id="28764594"/>
    <dbReference type="InParanoid" id="A0A177C386"/>
    <dbReference type="OrthoDB" id="5348546at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="2">
        <location>
            <begin position="117"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="362"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="429"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="282"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="375"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="440"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG01130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="522" mass="57562" checksum="1F9CB93FBB4BB740" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C3L9</accession>
    <name>A0A177C3L9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1100137</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441557">
        <property type="protein sequence ID" value="OAG01377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031742.1">
        <property type="nucleotide sequence ID" value="XM_018174851.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C3L9"/>
    <dbReference type="STRING" id="1460663.A0A177C3L9"/>
    <dbReference type="GeneID" id="28758337"/>
    <dbReference type="InParanoid" id="A0A177C3L9"/>
    <dbReference type="OrthoDB" id="2823490at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG01377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="334" mass="37397" checksum="8C7547D278AA77B7" modified="2016-09-07" version="1">MPQHLLSLPRELRDAIYDQLLLSTAPIPAIPDEKFMAYNPSPSRTFRKIYDAPSTLRGEFGCAYSLAPIPSTCAGFIACNRQVNQEMEEARERLGRKEGVWVRLDCLAVEESWHYFTLVSIPTVSTSLPPAQSRSVLPPWLRTYTALFLGSLLPWGIVSPPQTSTTRIPRLWIDVRLAGNRKDKYRRTSSPAGRTGWAVCAALKRLLYHGPELAADHERPSASVTYIGELVLNVVPPPPPVDGAPATLLDEDFPLDGDGEGTVHPRTVARELVGVWGKIWAGDEFKGILYGGLLERIGWVRVCVDGKTWRVRELRGVLERGQRERRRIAERGPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C3N5</accession>
    <name>A0A177C3N5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TPR-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_979700</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441556">
        <property type="protein sequence ID" value="OAG02016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032381.1">
        <property type="nucleotide sequence ID" value="XM_018188038.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C3N5"/>
    <dbReference type="STRING" id="1460663.A0A177C3N5"/>
    <dbReference type="GeneID" id="28771524"/>
    <dbReference type="InParanoid" id="A0A177C3N5"/>
    <dbReference type="OrthoDB" id="2423701at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051879">
        <property type="term" value="F:Hsp90 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22904:SF523">
        <property type="entry name" value="STRESS-INDUCED-PHOSPHOPROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22904">
        <property type="entry name" value="TPR REPEAT CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13414">
        <property type="entry name" value="TPR_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="2"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAG02016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="156" mass="17852" checksum="9036E20E0FB519F9" modified="2016-09-07" version="1">MADALKAEGNKLFAEKKFEESIEKFTQAIELDPSNHVLYSNRSGAYASLKDYTKAAKEAKAKADELKKQGTEFYKKRQFDEAIEKYNEAWETHKDITYKTNLGAAKFEKGDYEGCIQACNEAVEYGREIYAEYRSSWPRASSAWVARRAREGCVTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C3S5</accession>
    <name>A0A177C3S5_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 11">V-type proton ATPase subunit F</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CC84DRAFT_1167640</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 11">Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'', d, e, f and VOA1).</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Vacuole membrane</location>
            <topology evidence="8">Peripheral membrane protein</topology>
            <orientation evidence="8">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the V-ATPase F subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441557">
        <property type="protein sequence ID" value="OAG01438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031803.1">
        <property type="nucleotide sequence ID" value="XM_018179223.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C3S5"/>
    <dbReference type="FunCoup" id="A0A177C3S5">
        <property type="interactions" value="696"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177C3S5"/>
    <dbReference type="GeneID" id="28762709"/>
    <dbReference type="InParanoid" id="A0A177C3S5"/>
    <dbReference type="OrthoDB" id="10261947at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033180">
        <property type="term" value="C:proton-transporting V-type ATPase, V1 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10580:FF:000002">
        <property type="entry name" value="V-type proton ATPase subunit F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10580">
        <property type="entry name" value="ATPase, V1 complex, subunit F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008218">
        <property type="entry name" value="ATPase_V1-cplx_f_g_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005772">
        <property type="entry name" value="ATPase_V1-cplx_fsu_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036906">
        <property type="entry name" value="ATPase_V1_fsu_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01101">
        <property type="entry name" value="V_ATP_synt_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13861:SF2">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13861">
        <property type="entry name" value="VACUOLAR ATP SYNTHASE SUBUNIT F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01990">
        <property type="entry name" value="ATP-synt_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015945">
        <property type="entry name" value="ATPase_V1_F_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159468">
        <property type="entry name" value="AtpF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="6 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <keyword evidence="4" id="KW-0926">Vacuole</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00046254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR015945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OAG01438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="124" mass="13983" checksum="1ADE5E6AAC9607D9" modified="2016-09-07" version="1">MSASTAAYKDRQFLAVIGDEDTVTGMLLAGVGHVTQPPDSQKNFLVVDAKTQNADIEAAFDRFTQERKDIAILLINQHIAERIRHRVEMYTAAFPSLLEIPSKDHPYDPDKDSVLKRVRRLFGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2023-06-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C3Z6</accession>
    <name>A0A177C3Z6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1007125</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441556">
        <property type="protein sequence ID" value="OAG02215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032580.1">
        <property type="nucleotide sequence ID" value="XM_018173341.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C3Z6"/>
    <dbReference type="GeneID" id="28756827"/>
    <dbReference type="InParanoid" id="A0A177C3Z6"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG02215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="67" mass="7708" checksum="F9EC2D52ECDB0038" modified="2016-09-07" version="1">MAREVGKQRSKHSFKPLLGVEGSRLRVSDMARPYTRPAMKFATHLKHFFPPDTDCSKQFPSSIQFVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C466</accession>
    <name>A0A177C466_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">D-arabinono-1,4-lactone oxidase</fullName>
            <shortName evidence="9">ALO</shortName>
            <ecNumber evidence="4 9">1.1.3.37</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">L-galactono-gamma-lactone oxidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CC84DRAFT_1208696</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>D-arabinono-1,4-lactone + O2 = dehydro-D-arabinono-1,4-lactone + H2O2 + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23756"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:16292"/>
            <dbReference type="ChEBI" id="CHEBI:58277"/>
            <dbReference type="EC" id="1.1.3.37"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Cofactor biosynthesis; D-erythroascorbate biosynthesis; dehydro-D-arabinono-1,4-lactone from D-arabinose: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Mitochondrion membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.3.37" evidence="4 9"/>
    <dbReference type="EMBL" id="KV441557">
        <property type="protein sequence ID" value="OAG01588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031953.1">
        <property type="nucleotide sequence ID" value="XM_018182174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C466"/>
    <dbReference type="FunCoup" id="A0A177C466">
        <property type="interactions" value="69"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177C466"/>
    <dbReference type="GeneID" id="28765660"/>
    <dbReference type="InParanoid" id="A0A177C466"/>
    <dbReference type="OrthoDB" id="610608at2759"/>
    <dbReference type="UniPathway" id="UPA00771">
        <property type="reaction ID" value="UER00766"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003885">
        <property type="term" value="F:D-arabinono-1,4-lactone oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2520">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="entry name" value="Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007173">
        <property type="entry name" value="ALO_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010031">
        <property type="entry name" value="FAD_lactone_oxidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006093">
        <property type="entry name" value="Oxy_OxRdtase_FAD_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030654">
        <property type="entry name" value="Sugar_lactone_oxidase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01678">
        <property type="entry name" value="FAD_lactone_ox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43762:SF1">
        <property type="entry name" value="D-ARABINONO-1,4-LACTONE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43762">
        <property type="entry name" value="L-GULONOLACTONE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04030">
        <property type="entry name" value="ALO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00862">
        <property type="entry name" value="OX2_COVAL_FAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0274">FAD</keyword>
    <keyword evidence="5 9" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008057698" description="D-arabinono-1,4-lactone oxidase" evidence="11">
        <location>
            <begin position="19"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="12">
        <location>
            <begin position="216"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="145"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="744"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="147"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="753"/>
            <end position="763"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OAG01588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="763" mass="86443" checksum="5BB007841C7FD9D9" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C4G6</accession>
    <name>A0A177C4G6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CC84DRAFT_1220720</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the WD repeat PROPPIN family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441556">
        <property type="protein sequence ID" value="OAG02395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032760.1">
        <property type="nucleotide sequence ID" value="XM_018183193.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C4G6"/>
    <dbReference type="FunCoup" id="A0A177C4G6">
        <property type="interactions" value="386"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177C4G6"/>
    <dbReference type="GeneID" id="28766679"/>
    <dbReference type="InParanoid" id="A0A177C4G6"/>
    <dbReference type="OrthoDB" id="1667587at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048720">
        <property type="entry name" value="PROPPIN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11227">
        <property type="entry name" value="WD-REPEAT PROTEIN INTERACTING WITH PHOSPHOINOSIDES WIPI -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21032">
        <property type="entry name" value="PROPPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0853">WD repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAG02395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="378" mass="41441" checksum="98FD3A87B294BA8C" modified="2016-09-07" version="1">MNTRPVLDPTQQPFALAAAFNENNTFFSVAHEHGFKVFRAATCEAKIGRDLSGGLGCADMVGTTNFIILAGGGRSPHFPSNKIQIWNDQIQQVSGSLELKAPVLRVRATKEFLVVVLPYQVVAYRMGNPAQKIHTYETAENPFGLCSFEKNIVAMPGAQAGQVRLVRLVDGNLNPRVTLINAHTGHLRAVALNKTADKVATASEKGTIIRLYAVESGTKLGEFRRGIDEAAVFSIAFSPCDSMLAVTSDKSTVHVFDLPNGVQTKTDIDPKKHKYGIFSKIPFLPGPLSDTYSSASTRFEMGDEMGGWSSQSKAATKEVLSKFSPERVPTKGLLGWISNNEFLIIGAGQDARWEKFEVAVDESNNKYIQRKAWKRYLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2023-06-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C4H2</accession>
    <name>A0A177C4H2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_201427</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441557">
        <property type="protein sequence ID" value="OAG01570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031935.1">
        <property type="nucleotide sequence ID" value="XM_018185570.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C4H2"/>
    <dbReference type="GeneID" id="28769056"/>
    <dbReference type="InParanoid" id="A0A177C4H2"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG01570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="192" mass="21697" checksum="2E0CA304649A3AA6" modified="2016-09-07" version="1">MQVPAETAPCPRRQPSCPLVARKRCLRRSMQCTAADPCCVPPPSPFHRATMFLESRQETFQHTLDSRAPCNKAQLFRAVERIENQISHPCKIVRLRLIAAVIVFLLSDPLASSNAQARVFQQPVHALPTALNQEEHQFSAWTFIYLTHRPRIGDRLPGSWSSLHGFSAEAHSNVRSCRNLPRRPIYIPLADA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C6U5</accession>
    <name>A0A177C6U5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1218796</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG03474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033839.1">
        <property type="nucleotide sequence ID" value="XM_018183032.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C6U5"/>
    <dbReference type="STRING" id="1460663.A0A177C6U5"/>
    <dbReference type="GeneID" id="28766518"/>
    <dbReference type="InParanoid" id="A0A177C6U5"/>
    <dbReference type="OrthoDB" id="19653at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF3">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="2">
        <location>
            <begin position="50"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG03474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="329" mass="36852" checksum="807717CB4D626960" modified="2016-09-07" version="1">MDKQSVIPAEQRLDSFNIYRTHYKKIQDHEIELGILIPKDLSPGLHPVFVRFHGGGCKVSGTWAYPNWFANWLIPLVHNSNAIVVSPNYRLLPEHNGDDIQEDLADFWTWFKDGGVTKYLSSRAGPYAAIQLDYTRILAGGDSAGGYLAIQSGLTQPRGTLCAIIGCYPMTNYLRRKQEAIFMEEPSPPESIIDSAKEHLKTVETGTIISGAPPRPRNRLSYALSAYGRYTHFFGTGSHLWPISLLDSGAATYIPPTIIIHGDEDKAVSIDDSRLFVKRAAEVVREGEVRLVEIEGVDHGFDMEASEKQEWVRGVVKWVEERWVGRGVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C754</accession>
    <name>A0A177C754_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Mandelate racemase/muconate lactonizing protein-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CC84DRAFT_1122722</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG03473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033838.1">
        <property type="nucleotide sequence ID" value="XM_018175641.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C754"/>
    <dbReference type="STRING" id="1460663.A0A177C754"/>
    <dbReference type="GeneID" id="28759127"/>
    <dbReference type="InParanoid" id="A0A177C754"/>
    <dbReference type="OrthoDB" id="2579025at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008869">
        <property type="term" value="F:galactonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009063">
        <property type="term" value="P:amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034194">
        <property type="term" value="P:D-galactonate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03325">
        <property type="entry name" value="D-galactonate_dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="entry name" value="Enolase-like C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="entry name" value="Enolase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034593">
        <property type="entry name" value="DgoD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029065">
        <property type="entry name" value="Enolase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023592">
        <property type="entry name" value="Galactonate_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018110">
        <property type="entry name" value="Mandel_Rmase/mucon_lact_enz_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013342">
        <property type="entry name" value="Mandelate_racemase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013341">
        <property type="entry name" value="Mandelate_racemase_N_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010624">
        <property type="entry name" value="PRK14017.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48080:SF2">
        <property type="entry name" value="D-GALACTONATE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48080">
        <property type="entry name" value="D-GALACTONATE DEHYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13378">
        <property type="entry name" value="MR_MLE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02746">
        <property type="entry name" value="MR_MLE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00003">
        <property type="entry name" value="D-galactonate_dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00001">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00179">
        <property type="entry name" value="mandelate_racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00922">
        <property type="entry name" value="MR_MLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="Enolase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="Enolase N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00908">
        <property type="entry name" value="MR_MLE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mandelate racemase/muconate lactonizing enzyme C-terminal" evidence="5">
        <location>
            <begin position="126"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAG03473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="381" mass="42204" checksum="2D2B690712D9C1E4" modified="2016-09-07" version="1">MGKINKIEYFRVPPRWLFVKITDEVGNFGWGEASLEGHTQAVEGCLDAWIERYIGFEADDIEHIWQMSWRTSFYRGGPVFMSALAGLDIALWDLKARKLNVPIYQLLGGKVRSKLKVYAWIGGDRPSDVETQALARKAQGFLAVKMNATEDIGWLDSPSTLISSVERLKTVKALGMDAGMDFHGRIHKPMAKQLAAALEPHQPLFIEEPLLSEHIGGIKALAYHTSIPIALGERLHSRWDVRPFLEANCVDILQPDISHVGGISELKRIAAMCEAYDVALAPHCPLGPIALAACIQVDASVANFAIQEMSLGIHYNAGSQDLTSYITNPEVWKVDEGYVELMAGPGLGIEIDEEWVRRESKDSKAWVSPGFIGPGGEVREW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C7V5</accession>
    <name>A0A177C7V5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FabD/lysophospholipase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_861491</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG03635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034000.1">
        <property type="nucleotide sequence ID" value="XM_018187668.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C7V5"/>
    <dbReference type="STRING" id="1460663.A0A177C7V5"/>
    <dbReference type="GeneID" id="28771154"/>
    <dbReference type="InParanoid" id="A0A177C7V5"/>
    <dbReference type="OrthoDB" id="3799328at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF13">
        <property type="entry name" value="POLYKETIDE SYNTHASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Malonyl-CoA:ACP transacylase (MAT)" evidence="1">
        <location>
            <begin position="1"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG03635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="206" mass="22375" checksum="3FD3C35C61CC628B" modified="2016-09-07" version="1">MGRELYERYPVYTSAIDRADKHLLSLGATFSLLKELQKDETSTKINNAHLSQPSCTAVQLALVDLLRTWGITAKAVAGHSSGEIGAAYAAGIIDFEDAMTVVYHRGRLIPILKEKFPTLDGSMMAVGAGQADIAPLLERILRCVGEARIACINSPSSVTVSGDTDAILELQQLIEEAHPGTFARKLQVDTAYHSHHIRTSFPTGMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C804</accession>
    <name>A0A177C804_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">DnaJ homolog 1, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">BRO domain-containing protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">CC84DRAFT_1188425</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG03874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034239.1">
        <property type="nucleotide sequence ID" value="XM_018180988.1"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177C804"/>
    <dbReference type="GeneID" id="28764474"/>
    <dbReference type="InParanoid" id="A0A177C804"/>
    <dbReference type="OrthoDB" id="2141925at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031072">
        <property type="term" value="F:heat shock protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09242">
        <property type="entry name" value="BRO1_ScBro1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10747">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10719">
        <property type="entry name" value="DnaJ_zf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09237">
        <property type="entry name" value="V_ScBro1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.260.20:FF:000005">
        <property type="entry name" value="Chaperone protein dnaJ 1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000053">
        <property type="entry name" value="Putative Mitochondrial DnaJ chaperone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.560">
        <property type="entry name" value="alix/aip1 in complex with the ypdl late domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.50">
        <property type="entry name" value="alix/aip1 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.280">
        <property type="entry name" value="alix/aip1 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.230.10">
        <property type="entry name" value="Heat shock protein DnaJ, cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.260.20">
        <property type="entry name" value="Urease metallochaperone UreE, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01152">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025304">
        <property type="entry name" value="ALIX_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004328">
        <property type="entry name" value="BRO1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038499">
        <property type="entry name" value="BRO1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012724">
        <property type="entry name" value="DnaJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001305">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036410">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23030">
        <property type="entry name" value="PCD6 INTERACTING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23030:SF30">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13949">
        <property type="entry name" value="ALIX_LYPXL_bnd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03097">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00684">
        <property type="entry name" value="DnaJ_CXXCXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01041">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57938">
        <property type="entry name" value="DnaJ/Hsp40 cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="HSP40/DnaJ peptide-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51180">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51188">
        <property type="entry name" value="ZF_CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0967">Endosome</keyword>
    <keyword evidence="5 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="9 15" id="KW-0862">Zinc</keyword>
    <keyword evidence="8 15" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="J" evidence="17">
        <location>
            <begin position="69"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="CR-type" evidence="19">
        <location>
            <begin position="228"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="BRO1" evidence="18">
        <location>
            <begin position="532"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="CR-type" evidence="15">
        <location>
            <begin position="228"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="27"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="496"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1327"/>
            <end position="1514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="27"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="501"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="1362"/>
            <end position="1378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="1439"/>
            <end position="1458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="1459"/>
            <end position="1471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="1472"/>
            <end position="1491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00041284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00072890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="OAG03874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="1514" mass="165530" checksum="8F75268FCB2A136E" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C8C2</accession>
    <name>A0A177C8C2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Family 43 glycoside hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1250938</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG02950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033315.1">
        <property type="nucleotide sequence ID" value="XM_018184318.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C8C2"/>
    <dbReference type="STRING" id="1460663.A0A177C8C2"/>
    <dbReference type="GeneID" id="28767804"/>
    <dbReference type="InParanoid" id="A0A177C8C2"/>
    <dbReference type="OrthoDB" id="19657at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08983">
        <property type="entry name" value="GH43_Bt3655-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050727">
        <property type="entry name" value="GH43_arabinanases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43301">
        <property type="entry name" value="ARABINAN ENDO-1,5-ALPHA-L-ARABINOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43301:SF8">
        <property type="entry name" value="ARABINOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008057826" evidence="1">
        <location>
            <begin position="17"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG02950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="332" mass="36455" checksum="DF155484A70CA883" modified="2016-09-07" version="1">MRFFLTILTAASSAFAAAVLQDRSSNYVGYLISTFTDANPKVQFYLSNGNSPSSFRFLNKGQPVLTSTVGTKAVRDLFLATNSARNIWYMLGTDLDVYATGFSWEKVQTHGSKALVIWSSTDLVKWSSSTLATVEDNTAGMAWAPSAVWDDSTSQFYVFWSARTYAASDPGHTGSPSLDKIRYATTKDFKTFSAPADYYTIAGTPLIDQEFQYLGTAGHWARFLKNNSGSHVLEETTTGGLFGKWTRKPGYVTNDRPREGPVSFPDLQTAGLYHLWLDDTTTGYLPYQTSNIDGGAYTKSSYTSFPAGLKHGSVTPLTQSEYDAVLAQFPPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C8N0</accession>
    <name>A0A177C8N0_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CC84DRAFT_1123634</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG03993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034358.1">
        <property type="nucleotide sequence ID" value="XM_018175660.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C8N0"/>
    <dbReference type="FunCoup" id="A0A177C8N0">
        <property type="interactions" value="15"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177C8N0"/>
    <dbReference type="GeneID" id="28759146"/>
    <dbReference type="InParanoid" id="A0A177C8N0"/>
    <dbReference type="OrthoDB" id="427030at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001164">
        <property type="entry name" value="C2H2 finger domain protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051059">
        <property type="entry name" value="VerF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626">
        <property type="entry name" value="MIP31509P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626:SF11">
        <property type="entry name" value="ZINC FINGER PROTEIN YPR022C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="86"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="116"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="167"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="40"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="205"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="265"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="296"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="355"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAG03993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="1079" mass="119571" checksum="E0942F9B87FDEA99" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C8Y5</accession>
    <name>A0A177C8Y5_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_963665</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG03238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033603.1">
        <property type="nucleotide sequence ID" value="XM_018187981.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C8Y5"/>
    <dbReference type="STRING" id="1460663.A0A177C8Y5"/>
    <dbReference type="GeneID" id="28771467"/>
    <dbReference type="InParanoid" id="A0A177C8Y5"/>
    <dbReference type="OrthoDB" id="270167at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF16">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="445"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="2">
        <location>
            <begin position="77"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG03238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="468" mass="53599" checksum="E117ED077C539E4B" modified="2016-09-07" version="1">MQRDTDLTFGEIHGSHDSFVQNIEQIIDTALVKSEEEAPIRLRFLTRPESARVGPENTDPACYQLTSPHEHKPRMRYISVSYCWNHNQSSEGLTLPDYHIQVEPGSQRRPISCPPLVFHRSMRFARWQRCSYVWIDQECIMQTDPTDVERHLKVMHRVYGQSRWTVAVLATPISDEYNLEALLKVTRTPGSPNGRDFEIATVVALNLLHTISKDRWFSRTWAFQEKYCATSLHLLIPIAGFKITSYFKQHLLGDEVDSSWDFCLPIKIVRKLLMRLRSGPSAAKIADHWNSKDGLSFRDTIENLGIWYHNVGQSIVGEGILDWFENSHLIHGAFAMLEICDNLVVADRISIFGNLCELPYRLLSNRLNDPQYSYSTCLLALLLANFFPGPQQRAEAIKRYAWHIRDHTLGSTLETELFAQAIDASDPEHISDVMQSGKTVGWGRFCAIFFIGSIVLLQFLTVFNVLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C983</accession>
    <name>A0A177C983_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Expansin-like EG45 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1260793</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG03681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034046.1">
        <property type="nucleotide sequence ID" value="XM_018185011.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C983"/>
    <dbReference type="STRING" id="1460663.A0A177C983"/>
    <dbReference type="GeneID" id="28768497"/>
    <dbReference type="InParanoid" id="A0A177C983"/>
    <dbReference type="OrthoDB" id="5823761at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="entry name" value="RlpA-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007112">
        <property type="entry name" value="Expansin/allergen_DPBB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22514">
        <property type="entry name" value="EXPB1_D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50685">
        <property type="entry name" value="Barwin-like endoglucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50842">
        <property type="entry name" value="EXPANSIN_EG45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Expansin-like EG45" evidence="1">
        <location>
            <begin position="67"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG03681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="202" mass="20552" checksum="3B17724E0D57666E" modified="2016-09-07" version="1">MCCRFVSASNWISTSLRQPLTHPLAHQSSTMMSMILLTAAAFSTTTTAATTYKASFTQYGSTDTWGSGNCNVASTACGFYTSPGYSAAVSQNEFGVGPGAGAGPGCGTCWKLTVQTDSSGNDLSNAGNSIVVQVTNLCPASGNPLCAQNGLTGTNQYGANLNFDLCIDSGASKALFGNSGVGLAVGSAVQVDCNQWSGKVVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C9J7</accession>
    <name>A0A177C9J7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Conserved oligomeric Golgi complex subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Component of oligomeric Golgi complex 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CC84DRAFT_1056751</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COG2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG04424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034789.1">
        <property type="nucleotide sequence ID" value="XM_018173546.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C9J7"/>
    <dbReference type="STRING" id="1460663.A0A177C9J7"/>
    <dbReference type="GeneID" id="28757032"/>
    <dbReference type="InParanoid" id="A0A177C9J7"/>
    <dbReference type="OrthoDB" id="332281at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017119">
        <property type="term" value="C:Golgi transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009316">
        <property type="entry name" value="COG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024602">
        <property type="entry name" value="COG_su2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12961">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX COMPONENT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12961:SF0">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06148">
        <property type="entry name" value="COG2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Conserved oligomeric Golgi complex subunit 2 N-terminal" evidence="10">
        <location>
            <begin position="18"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="155"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="159"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF06148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OAG04424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="267" mass="29058" checksum="11301A961F1B030F" modified="2016-09-07" version="1" fragment="single">SASDSDSENDATLPYPAPLSRSSFLSPTFTPQSYLSTLSNRHQTLEDLRSDLRARSALLSRELLDLVNTHYTDFLTLGASLRGGDEKVEEVRVGLLGFGKEVGALAERVGEREQEVKALVEERERIRRGVVVGRRLVGFEEGLKGVEEGLGIVEVAASDSEDEDDEDEDEDDEEGMVGGVSIAKLARHVLQWRVVREAEKGLTGHPFVVAQAPRMAKVRSTLLLDLSAALRQAKAAGAKGSVVRIMKVYADMGEEGEAVKVLKGLRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CB45</accession>
    <name>A0A177CB45_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Altered inheritance of mitochondria protein 41</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">AIM41</name>
        <name evidence="2" type="ORF">CC84DRAFT_878947</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the AIM41 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG03997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034362.1">
        <property type="nucleotide sequence ID" value="XM_018187766.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CB45"/>
    <dbReference type="FunCoup" id="A0A177CB45">
        <property type="interactions" value="85"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CB45"/>
    <dbReference type="GeneID" id="28771252"/>
    <dbReference type="InParanoid" id="A0A177CB45"/>
    <dbReference type="OrthoDB" id="538640at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016884">
        <property type="term" value="F:carbon-nitrogen ligase activity, with glutamine as amido-N-donor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1510.10">
        <property type="entry name" value="Uncharacterised protein YqeY/AIM41 PF09424, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003789">
        <property type="entry name" value="Asn/Gln_tRNA_amidoTrase-B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019004">
        <property type="entry name" value="YqeY/Aim41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042184">
        <property type="entry name" value="YqeY/Aim41_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28055">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 41, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28055:SF1">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 41, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09424">
        <property type="entry name" value="YqeY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89095">
        <property type="entry name" value="GatB/YqeY motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU365099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG03997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="182" mass="20227" checksum="255B879DAE4516F5" modified="2016-09-07" version="1">MSLFRLARFPALQQPLLRRTFLTTRPLFHADTVVKSLKPELMTAMRAKDKPRLTVLRALLAEITNASKTNKPVDDDPALYSLLAKQIKASNAAVEEFVQAKREDLVEKERGQILILEGFLNQIEVVPEQTIRQFAEEVVAEIKGEAKTGAVMGKVMKKIGGKPVDMVMAGRVVEEVVAEKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CC03</accession>
    <name>A0A177CC03_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1217788</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG04317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034682.1">
        <property type="nucleotide sequence ID" value="XM_018182930.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CC03"/>
    <dbReference type="GeneID" id="28766416"/>
    <dbReference type="InParanoid" id="A0A177CC03"/>
    <dbReference type="OrthoDB" id="3798738at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008057988" evidence="1">
        <location>
            <begin position="18"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG04317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="106" mass="12151" checksum="8FBD61AC64FBBF97" modified="2016-09-07" version="1">MHFSATLLPALVALTSAAAVPRSTYGQWTVSATVSPDHSVYVTAKYTSDAYPDDKYMNRSCVENPFATPPVEKRCDRTDFTYEYDARSKFYQYLHLPQERGRESRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CC97</accession>
    <name>A0A177CC97_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_1248156</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG05283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035648.1">
        <property type="nucleotide sequence ID" value="XM_018184251.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CC97"/>
    <dbReference type="STRING" id="1460663.A0A177CC97"/>
    <dbReference type="GeneID" id="28767737"/>
    <dbReference type="InParanoid" id="A0A177CC97"/>
    <dbReference type="OrthoDB" id="443402at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056693">
        <property type="entry name" value="DUF7791"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF5">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25053">
        <property type="entry name" value="DUF7791"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="2">
        <location>
            <begin position="249"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7791" evidence="3">
        <location>
            <begin position="525"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="661"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAG05283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="661" mass="75267" checksum="72CC4F112573EECC" modified="2016-09-07" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CCA5</accession>
    <name>A0A177CCA5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Mitochondrial GTPase 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CC84DRAFT_1164844</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG04350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034715.1">
        <property type="nucleotide sequence ID" value="XM_018178580.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CCA5"/>
    <dbReference type="FunCoup" id="A0A177CCA5">
        <property type="interactions" value="719"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CCA5"/>
    <dbReference type="GeneID" id="28762066"/>
    <dbReference type="InParanoid" id="A0A177CCA5"/>
    <dbReference type="OrthoDB" id="269151at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01856">
        <property type="entry name" value="YlqF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1580.10:FF:000009">
        <property type="entry name" value="Mitochondrial GTPase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023179">
        <property type="entry name" value="GTP-bd_ortho_bundle_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45782">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOME-ASSOCIATED GTPASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45782:SF4">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOME-ASSOCIATED GTPASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G" evidence="4">
        <location>
            <begin position="139"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="333"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="346"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAG04350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="361" mass="40203" checksum="3CCF047CED0EEE80" modified="2016-09-07" version="1">MSFVPRAAFPSLSHLPRSYFLGHHKSGLQKMKTLLSSIDLVIECRDYRVPLTSRNPLFEESLEGKERLIVYTKRDLGGPARDSRNEEVITKWHAPTPTMFIRNSSDEEGKASRRRSVEKLLEFLREHAQQRWKLVGHRLLVVGMPNVGKSTLLNALRAHGIGKGKVAKTGAQPGVTRKIGSGVKIIPSEDDAESMDETSRKRYKGVGGGVYLVDTPGVFIPYVPDAEAMMKLALCGSVKDSIIPPVMLADYLLYHMNLIDTTLYAEYVHGPTNDIVELLEGIAKRTGRLGKGGKADTEATALWMIQKWRTGNMGKFLLDGVTEQGLEVSKLAEQERVPSMNQARKAQREVRRARNKARGEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CCJ1</accession>
    <name>A0A177CCJ1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CC84DRAFT_1260544</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG05355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035720.1">
        <property type="nucleotide sequence ID" value="XM_018184994.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CCJ1"/>
    <dbReference type="GeneID" id="28768480"/>
    <dbReference type="InParanoid" id="A0A177CCJ1"/>
    <dbReference type="OrthoDB" id="3677098at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="454"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="454"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="177"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="426"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="513"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="638"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="179"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="230"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="439"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="520"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="638"/>
            <end position="653"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAG05355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="661" mass="71899" checksum="EA75BBBFCE48931A" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CCL2</accession>
    <name>A0A177CCL2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Pantothenate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CC84DRAFT_1243612</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG05394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035759.1">
        <property type="nucleotide sequence ID" value="XM_018184120.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CCL2"/>
    <dbReference type="GeneID" id="28767606"/>
    <dbReference type="InParanoid" id="A0A177CCL2"/>
    <dbReference type="OrthoDB" id="2985014at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000057">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF91">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="168"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="204"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="236"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="304"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="343"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="373"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="398"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAG05394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="452" mass="50168" checksum="9A1622522BB5FA3C" modified="2016-09-07" version="1">MLDTKEQTAAASSAVDASPENTLHYARRGSLVAETAADPNIEGYDAERMRARALLSADEEKKLLRKIDWHLMALCSIMFLLKNIDADNVSNARIMNKGSPTNIMNQLGMTSNEYNLVTTLYYIPYIVAEAPSNLLIKRLLPSRWQSRIMVTWGIALSCHAAVTNKEGLYVARFFLGLFEAGLFPGVILQMCYWYRPDEMSVRLLYFYILGNLSGVVSGLLAFAFSHLDGAHGLSGWQWIFLVEGIITIAFGVAIYFIFPDFPPQAKWLTDDEKAFIQARLPGNAPQAAEMNFNWREIVESLKDIRLWLFTLIWALFTIGNSGVRFYQPTVIADLGYTDVASAQLLNLPISIFSIIVIGITGAFADNGKLPRPLYPLAFLCIILACYGTLYAYPNSGGVYAATLIGNGLTSAWYPMMWPWRVQTTSKATGSAFSIGFVNSYGQVSSVLQVHSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CD58</accession>
    <name>A0A177CD58_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Roadblock/LAMTOR2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_1165468</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GAMAD family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG05141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035506.1">
        <property type="nucleotide sequence ID" value="XM_018178721.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CD58"/>
    <dbReference type="STRING" id="1460663.A0A177CD58"/>
    <dbReference type="GeneID" id="28762207"/>
    <dbReference type="InParanoid" id="A0A177CD58"/>
    <dbReference type="OrthoDB" id="9985637at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.30">
        <property type="entry name" value="Dynein light chain 2a, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004942">
        <property type="entry name" value="Roadblock/LAMTOR2_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10779">
        <property type="entry name" value="DYNEIN LIGHT CHAIN ROADBLOCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00960">
        <property type="entry name" value="Robl_LC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103196">
        <property type="entry name" value="Roadblock/LC7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Roadblock/LAMTOR2" evidence="3">
        <location>
            <begin position="9"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="42"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="42"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAG05141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="135" mass="14472" checksum="AAE2CFBE93024C29" modified="2016-09-07" version="1">MAEKTSDETLAHLTRISQKPGVQSTLILSRENGAIVRTSGLISNSTSANPNSALPASNDATPDNYTNGKKEGGIQNAEDVASKVWSFLTAAGALVDGLYEEDEVKLLRLRTKKNELVIIPDTKFILVLVHDTPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CD83</accession>
    <name>A0A177CD83_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_833967</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG05266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035631.1">
        <property type="nucleotide sequence ID" value="XM_018187582.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CD83"/>
    <dbReference type="STRING" id="1460663.A0A177CD83"/>
    <dbReference type="GeneID" id="28771068"/>
    <dbReference type="InParanoid" id="A0A177CD83"/>
    <dbReference type="OrthoDB" id="2133190at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11395">
        <property type="entry name" value="bHLHzip_SREBP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052099">
        <property type="entry name" value="Regulatory_TF_Diverse"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47336">
        <property type="entry name" value="TRANSCRIPTION FACTOR HMS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47336:SF2">
        <property type="entry name" value="TRANSCRIPTION FACTOR HMS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BHLH" evidence="2">
        <location>
            <begin position="194"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="180"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG05266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="283" mass="30829" checksum="C8D60D0C110F8D11" modified="2016-09-07" version="1">MDYIDYSSFPMLASTDCSPTTENFSYPTAFDKAFVGDPFTGNDAPLTAFDYFGRPVSSATATESLNATSSVAPTGPQLESPLAHHPFGQLDVFSSGFPWDTNPLPPTALDLNLSPLSDDSRTPSLCGDAPQPSVLASPPPSPQPQSHSRRQSTSSSLLKFEDPSAAPPKRRRGRPRLDRSSSSLSSTNSKNPRAQRLPHNQVERKYREGLNATLERLRQTVPALCVEDKFGLGGVVGHPKPSKAMILEGAIEYIREIERERDAFRGEVERLRRASGAWDSAAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CDQ9</accession>
    <name>A0A177CDQ9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_735129</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG05773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036138.1">
        <property type="nucleotide sequence ID" value="XM_018187225.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CDQ9"/>
    <dbReference type="STRING" id="1460663.A0A177CDQ9"/>
    <dbReference type="GeneID" id="28770711"/>
    <dbReference type="InParanoid" id="A0A177CDQ9"/>
    <dbReference type="OrthoDB" id="4236860at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051430">
        <property type="entry name" value="Fungal_TF_Env_Response"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31944">
        <property type="entry name" value="HEME-RESPONSIVE ZINC FINGER TRANSCRIPTION FACTOR HAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31944:SF130">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTO (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="7">
        <location>
            <begin position="53"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAG05773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="562" mass="61746" checksum="20F5D1C5A6A28B72" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CDS2</accession>
    <name>A0A177CDS2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1244290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG05783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036148.1">
        <property type="nucleotide sequence ID" value="XM_018184147.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CDS2"/>
    <dbReference type="GeneID" id="28767633"/>
    <dbReference type="InParanoid" id="A0A177CDS2"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="151"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="213"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="267"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG05783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="327" mass="32440" checksum="5BE2A65B649A5D6E" modified="2016-09-07" version="1">MAHFLSGVPAAPQTPTGAGHRLCCQVMYLPQTAQRSSSALFCPSPTLPRLKIPHRLALCSQALSSAASRRRWPTTQVGSQHLLLFQYGTTTTGMMSTKTVAGATSTNLCTFCSGTTSNASGATPEVTQVVTTREVKPSAPPSNAPESVKPSSLASSNTSASISSASGSVRHSALRRGNSSTTGSSSSSMTGNGILTRTSTARASTTKQASLASPTQSSPIFSSSAGLLSIPSTGGPTSSPPNGLNPTSSGSSTSTRPSPSFLAKTLSTTSSGQSAAATSSIGPDPTSTASEPSPQPSASSSAGESSSFGTAGATASSVEGPSGSNGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CDV3</accession>
    <name>A0A177CDV3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">adenosine deaminase</fullName>
            <ecNumber evidence="4">3.5.4.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CC84DRAFT_1145480</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>adenosine + H2O + H(+) = inosine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:24408"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16335"/>
            <dbReference type="ChEBI" id="CHEBI:17596"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.4.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. ADGF subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.4" evidence="4"/>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG05815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036180.1">
        <property type="nucleotide sequence ID" value="XM_018176513.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CDV3"/>
    <dbReference type="STRING" id="1460663.A0A177CDV3"/>
    <dbReference type="GeneID" id="28759999"/>
    <dbReference type="InParanoid" id="A0A177CDV3"/>
    <dbReference type="OrthoDB" id="7202371at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004000">
        <property type="term" value="F:adenosine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006154">
        <property type="term" value="P:adenosine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046103">
        <property type="term" value="P:inosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01321">
        <property type="entry name" value="ADGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000017">
        <property type="entry name" value="Adenosine deaminase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001365">
        <property type="entry name" value="A_deaminase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006330">
        <property type="entry name" value="Ado/ade_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11409">
        <property type="entry name" value="ADENOSINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11409:SF39">
        <property type="entry name" value="ADENOSINE DEAMINASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00962">
        <property type="entry name" value="A_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Adenosine deaminase" evidence="10">
        <location>
            <begin position="227"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OAG05815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="574" mass="65497" checksum="A8DAAB0A74FD4E7F" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CE39</accession>
    <name>A0A177CE39_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Rpr2-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CC84DRAFT_818642</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the eukaryotic/archaeal RNase P protein component 4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG05027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035392.1">
        <property type="nucleotide sequence ID" value="XM_018187527.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CE39"/>
    <dbReference type="FunCoup" id="A0A177CE39">
        <property type="interactions" value="13"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CE39"/>
    <dbReference type="GeneID" id="28771013"/>
    <dbReference type="InParanoid" id="A0A177CE39"/>
    <dbReference type="OrthoDB" id="128536at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005655">
        <property type="term" value="C:nucleolar ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007175">
        <property type="entry name" value="Rpr2/Snm1/Rpp21"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14742:SF0">
        <property type="entry name" value="RIBONUCLEASE P PROTEIN SUBUNIT P21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14742">
        <property type="entry name" value="RIBONUCLEASE P SUBUNIT P21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04032">
        <property type="entry name" value="Rpr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="134"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="164"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAG05027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="180" mass="19552" checksum="4563E1B98C003819" modified="2016-09-07" version="1">MAKDKPPKTKGVPNKHLHSRSTFLYQAATYLTLHAAALDANEAPDSAQSSGTTGSRHRLALQLASDLQNVSRKGQVRLSSELKRTICKTCNTVLIPGRTATQTIENESKGGKKSWADVLVVMCTLCGSKKRFPIGAQRQEKKSERQPTQAQRSLSEKSAEEPTSIASPMQMTTDQDSTPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CE94</accession>
    <name>A0A177CE94_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">LIM-domain binding protein-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_833045</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG05232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035597.1">
        <property type="nucleotide sequence ID" value="XM_018187573.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CE94"/>
    <dbReference type="STRING" id="1460663.A0A177CE94"/>
    <dbReference type="GeneID" id="28771059"/>
    <dbReference type="InParanoid" id="A0A177CE94"/>
    <dbReference type="OrthoDB" id="774557at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029005">
        <property type="entry name" value="LIM-bd/SEUSS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10378">
        <property type="entry name" value="LIM DOMAIN-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01803">
        <property type="entry name" value="LIM_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="227"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="531"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="621"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="159"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="181"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="227"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="273"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="288"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="311"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="628"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="679"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="693"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="708"/>
            <end position="719"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG05232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="760" mass="83333" checksum="854B6EB2970AA4A5" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CED4</accession>
    <name>A0A177CED4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BRCT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_827977</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG05127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035492.1">
        <property type="nucleotide sequence ID" value="XM_018187548.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CED4"/>
    <dbReference type="STRING" id="1460663.A0A177CED4"/>
    <dbReference type="GeneID" id="28771034"/>
    <dbReference type="InParanoid" id="A0A177CED4"/>
    <dbReference type="OrthoDB" id="446168at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00533">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRCT" evidence="2">
        <location>
            <begin position="12"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="2">
        <location>
            <begin position="153"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG05127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="288" mass="30642" checksum="467FF0363B70F9F1" modified="2016-09-07" version="1">MAPKKAAPSISVRPDALSDEKCIITGEIDGFKRKEAEQILINAGATIEKSLNKKVTLVVLGADAGPQKLEKIEKLGIETKDWDELIEEIKGDGGAAPADDDEEDDEDEEVDEPEEPKPKKKAAPKEKAAPKPKANTKAKADPAPAAKPAASGSGDDFLSAKHVIITGTITGHDRKDAQAILEKEGAIFEKSLNKKVELVVLGQNPGPDKLAKIKELGAETIEWKEVAEKLGLELAPEKKVANVEAGDAPDSIDGKTLLITGEIDGFTRSKLGIDAEASEPPKKKAKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CF16</accession>
    <name>A0A177CF16_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FAD dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1090550</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG05419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035784.1">
        <property type="nucleotide sequence ID" value="XM_018174359.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CF16"/>
    <dbReference type="STRING" id="1460663.A0A177CF16"/>
    <dbReference type="GeneID" id="28757845"/>
    <dbReference type="InParanoid" id="A0A177CF16"/>
    <dbReference type="OrthoDB" id="5340195at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847:SF289">
        <property type="entry name" value="GLYCINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847">
        <property type="entry name" value="SARCOSINE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="2">
        <location>
            <begin position="10"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG05419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="381" mass="41501" checksum="1B3EE7B2C71FD0D3" modified="2016-09-07" version="1">MSYFEAPQNVIVIGGGIVGSSIAWHLSKSPTTNTTIIAEQIGGVATPNSFAWVNAGSTDKRFYYNFRHRSMAHWHEIEEAVPELSKYIHWGASLNWDIANETERAEYGERLMKWGYDVITVNKTEIPTYESEFEESFLKTDWALRYTEEGQMEAHIVAEKLIDDAQTNGAGLLKTNVTSFLKKDGKIVGVVIDGGEEVYADHVVLAGGLGSVPLLAAVGVDLPLTPKAGLLINTVPTERKLLNGVVYSHDLHLRQTADGRIRTGSDFGGSDPTDNPQAVADDLFVKLQAAFKGGDEIKYDYYTIGYRPTPEDGLPILGETGVHGLTVATMHSGVSNGALVGKLISEMVLTGEKDPALADFALSRFSNGTTSASKRRIRVDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CF85</accession>
    <name>A0A177CF85_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MBOAT-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_729979</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG05602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035967.1">
        <property type="nucleotide sequence ID" value="XM_018187197.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CF85"/>
    <dbReference type="FunCoup" id="A0A177CF85">
        <property type="interactions" value="517"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CF85"/>
    <dbReference type="GeneID" id="28770683"/>
    <dbReference type="InParanoid" id="A0A177CF85"/>
    <dbReference type="OrthoDB" id="286734at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003841">
        <property type="term" value="F:1-acylglycerol-3-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047184">
        <property type="term" value="F:1-acylglycerophosphocholine O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046474">
        <property type="term" value="P:glycerophospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030258">
        <property type="term" value="P:lipid modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049941">
        <property type="entry name" value="LPLAT_7/PORCN-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004299">
        <property type="entry name" value="MBOAT_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13906:SF4">
        <property type="entry name" value="LYSOPHOSPHOLIPID ACYLTRANSFERASE 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13906">
        <property type="entry name" value="PORCUPINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03062">
        <property type="entry name" value="MBOAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="23"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="52"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="227"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="422"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="454"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAG05602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="594" mass="67466" checksum="678F07D61ACD42D5" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CG57</accession>
    <name>A0A177CG57_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Macro domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1259072</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG05677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036042.1">
        <property type="nucleotide sequence ID" value="XM_018184879.1"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CG57"/>
    <dbReference type="GeneID" id="28768365"/>
    <dbReference type="InParanoid" id="A0A177CG57"/>
    <dbReference type="OrthoDB" id="6133115at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="entry name" value="Leucine Aminopeptidase, subunit E, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058348">
        <property type="entry name" value="DUF8035"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002589">
        <property type="entry name" value="Macro_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058925">
        <property type="entry name" value="zf-C2H2_AcuF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11106">
        <property type="entry name" value="GANGLIOSIDE INDUCED DIFFERENTIATION ASSOCIATED PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11106:SF27">
        <property type="entry name" value="MACRO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26118">
        <property type="entry name" value="DUF8035"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01661">
        <property type="entry name" value="Macro"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26082">
        <property type="entry name" value="zf-C2H2_AcuF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00506">
        <property type="entry name" value="A1pp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="Macro domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51154">
        <property type="entry name" value="MACRO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Macro" evidence="2">
        <location>
            <begin position="815"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="domain" description="Macro" evidence="2">
        <location>
            <begin position="1236"/>
            <end position="1419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="245"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="494"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="586"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="764"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1835"/>
            <end position="1858"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2070"/>
            <end position="2132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="285"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="499"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="518"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="764"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="2092"/>
            <end position="2104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG05677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="2221" mass="249318" checksum="12EDD1A08B9B70B9" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CG59</accession>
    <name>A0A177CG59_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein-lysine N-methyltransferase EFM4</fullName>
            <ecNumber evidence="5">2.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Elongation factor methyltransferase 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">EFM4</name>
        <name evidence="7" type="ORF">CC84DRAFT_761490</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">S-adenosyl-L-methionine-dependent protein-lysine N-methyltransferase that mono- and dimethylates elongation factor 1-alpha at 'Lys-316'. May play a role in intracellular transport.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM4 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="5"/>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG06336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036701.1">
        <property type="nucleotide sequence ID" value="XM_018187337.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CG59"/>
    <dbReference type="FunCoup" id="A0A177CG59">
        <property type="interactions" value="752"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CG59"/>
    <dbReference type="GeneID" id="28770823"/>
    <dbReference type="InParanoid" id="A0A177CG59"/>
    <dbReference type="OrthoDB" id="10069295at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03188">
        <property type="entry name" value="Methyltr_EFM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026635">
        <property type="entry name" value="Efm4/METTL10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12843:SF5">
        <property type="entry name" value="EEF1A LYSINE METHYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12843">
        <property type="entry name" value="PROTEIN-LYSINE N-METHYLTRANSFERASE METTL10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13847">
        <property type="entry name" value="Methyltransf_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 5 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Methyltransferase" evidence="6">
        <location>
            <begin position="86"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAG06336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="251" mass="27721" checksum="6638E7C03470FAEC" modified="2016-09-07" version="1">MAQKPEHLNTSALGTRAYWDTAYTTELSNFTADPADEGTVWFADAGAEERMLAFLETLADADVLHKEADGEVAQGAEDEAFVAPSRFLDLGTGNGHLLFALREDGWEGEMVGVDYSGVSVRLAEEIKATKGEEYEDVKFREFDILKGKAEGEWLGEGFDVVLDKGTFDAISLSEEVDAQGRRVAEGYREAVEKLVKKGGRFLITSCNWTEDEVKGWFDGGQLVYEDRAEYPSFTFGGKTGSSVCTLCFKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CGS3</accession>
    <name>A0A177CGS3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">Adenylyl cyclase-associated protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CC84DRAFT_1145894</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">The N-terminal domain binds to adenylyl cyclase, thereby enabling adenylyl cyclase to be activated by upstream regulatory signals, such as Ras. The C-terminal domain is required for normal cellular morphology and growth control.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the CAP family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG06058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036423.1">
        <property type="nucleotide sequence ID" value="XM_018176530.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CGS3"/>
    <dbReference type="FunCoup" id="A0A177CGS3">
        <property type="interactions" value="733"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CGS3"/>
    <dbReference type="GeneID" id="28760016"/>
    <dbReference type="InParanoid" id="A0A177CGS3"/>
    <dbReference type="OrthoDB" id="77251at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000935">
        <property type="term" value="C:division septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035838">
        <property type="term" value="C:growing cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008179">
        <property type="term" value="F:adenylate cyclase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030042">
        <property type="term" value="P:actin filament depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051014">
        <property type="term" value="P:actin filament severing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010619">
        <property type="term" value="P:adenylate cyclase-activating glucose-activated G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019933">
        <property type="term" value="P:cAMP-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030308">
        <property type="term" value="P:negative regulation of cell growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031138">
        <property type="term" value="P:negative regulation of conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030836">
        <property type="term" value="P:positive regulation of actin filament depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090141">
        <property type="term" value="P:positive regulation of mitochondrial fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046579">
        <property type="term" value="P:positive regulation of Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030833">
        <property type="term" value="P:regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.330:FF:000001">
        <property type="entry name" value="Adenylyl cyclase-associated protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.70:FF:000008">
        <property type="entry name" value="Adenylyl cyclase-associated protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.330">
        <property type="entry name" value="Adenylate cyclase-associated CAP, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001837">
        <property type="entry name" value="Adenylate_cyclase-assoc_CAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013912">
        <property type="entry name" value="Adenylate_cyclase-assoc_CAP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013992">
        <property type="entry name" value="Adenylate_cyclase-assoc_CAP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017901">
        <property type="entry name" value="C-CAP_CF_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016098">
        <property type="entry name" value="CAP/MinC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036223">
        <property type="entry name" value="CAP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018106">
        <property type="entry name" value="CAP_CS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053950">
        <property type="entry name" value="CAP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036222">
        <property type="entry name" value="CAP_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006599">
        <property type="entry name" value="CARP_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10652">
        <property type="entry name" value="ADENYLYL CYCLASE-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10652:SF0">
        <property type="entry name" value="ADENYLYL CYCLASE-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08603">
        <property type="entry name" value="CAP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21938">
        <property type="entry name" value="CAP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01213">
        <property type="entry name" value="CAP_N-CM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00673">
        <property type="entry name" value="CARP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69340">
        <property type="entry name" value="C-terminal domain of adenylylcyclase associated protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101278">
        <property type="entry name" value="N-terminal domain of adenylylcyclase associated protein, CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51329">
        <property type="entry name" value="C_CAP_COFACTOR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01088">
        <property type="entry name" value="CAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C-CAP/cofactor C-like" evidence="6">
        <location>
            <begin position="371"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="31"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="245"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="317"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="248"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="260"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="361"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00054756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00072052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAG06058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="526" mass="55970" checksum="2B7E1024A81FD114" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CGT1</accession>
    <name>A0A177CGT1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Exo-polygalacturonase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CC84DRAFT_1241499</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the glycosyl hydrolase 28 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG06774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037139.1">
        <property type="nucleotide sequence ID" value="XM_018184055.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CGT1"/>
    <dbReference type="STRING" id="1460663.A0A177CGT1"/>
    <dbReference type="GeneID" id="28767541"/>
    <dbReference type="InParanoid" id="A0A177CGT1"/>
    <dbReference type="OrthoDB" id="187139at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004650">
        <property type="term" value="F:polygalacturonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000743">
        <property type="entry name" value="Glyco_hydro_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31736">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31736:SF8">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_7G06410)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00295">
        <property type="entry name" value="Glyco_hydro_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OAG06774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="405" mass="44752" checksum="2F591980A5AC1973" modified="2016-09-07" version="1">MAPEIQWRTSTSKTCEVRSGDPSGDDASAILEAFEKCKEDGHILFTNTTYYVGRAMKTTGLKDVDIELQGTMEWSKDIDYWLNNSIPIGFQNQSAAWLLGGDNIRFYGHGYGTLFGNGDVWYVFNNGTSNLQGRPHAISIYNTTNSLVEGLRFIQSQMWTSTVMRSERVELSNIYVNNSCITQFDRCNVNTDGVDTIYANYITFLRWSVESGDDSISMKQNSSNIYMANNTFHRGLAYAMGSIGQYENQVNFIENITAIDTVFIDTAYAGRIKSWTGRNTGVPPNGGGGGLGWARNISFTNFTLQNVDTPWYITQCTSYNGVKGGCDTSLFHIDNMHWGNTTGTTKNNLVLSLQCSGAAPCTNINIFDNDLTVHKNGTTPTEFLCSNVDDPKGFKCTGKAPNTSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CH28</accession>
    <name>A0A177CH28_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glutathione S-transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CC84DRAFT_1090326</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the GST superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG06252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036617.1">
        <property type="nucleotide sequence ID" value="XM_018174347.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CH28"/>
    <dbReference type="FunCoup" id="A0A177CH28">
        <property type="interactions" value="690"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CH28"/>
    <dbReference type="GeneID" id="28757833"/>
    <dbReference type="InParanoid" id="A0A177CH28"/>
    <dbReference type="OrthoDB" id="422574at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd10291">
        <property type="entry name" value="GST_C_YfcG_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03048">
        <property type="entry name" value="GST_N_Ure2p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000172">
        <property type="entry name" value="Glutathione S-transferase GstA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051:SF8">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE GSTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00043">
        <property type="entry name" value="GST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01151">
        <property type="entry name" value="Main.2:_Nu-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST N-terminal" evidence="4">
        <location>
            <begin position="4"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="5">
        <location>
            <begin position="97"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="234"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="244"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAG06252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="254" mass="29212" checksum="B93626BA9310CB1B" modified="2016-09-07" version="1">MADQSDITLYTTQTPNGIKISIALEELGLPYKVHKIEFSKNTQKEPWFLEINPNGRIPALTDTFSDGKTINLFESGSIMQYLVSRYDTEHKISYPQGSREWYEMNNWLFFQNAGVGPMQGQANHFTRYAPEHIEYGVNRYQNETKRLYGVLDTHLSEKKIPYLTGEKCTIADIAHWGWIAAAGWCGIDIEHFPALKAWEERMAARPAVEKGRHVPDPHTIKELLKDKEAMEKHAAESRAWVQKGMKEDAEKLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CII8</accession>
    <name>A0A177CII8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1204712</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG07126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037491.1">
        <property type="nucleotide sequence ID" value="XM_018181925.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CII8"/>
    <dbReference type="GeneID" id="28765411"/>
    <dbReference type="InParanoid" id="A0A177CII8"/>
    <dbReference type="OrthoDB" id="5421765at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="130"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG07126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="449" mass="47919" checksum="FCC293C873C470D1" modified="2016-09-07" version="1">MSHWTCYTDPATCLEVSGAVPTSGADTEPTDVFFPNPTNGAGDEGKPKTTKTTRTADDGKPVQTDDNTKPEATKPLESSSIRHVTVLATTVSGSTAEPTIAVETSVPSVAAGTANGNNGSGGGGGMSPGAVAGIAVATAIVGAAIAFFAAFVLFKRRRPSRHGHSESSTNFISKGEQPSYVQISQVGPPPVLAAAILPTNRGVDLSDLSHSSDFLAAVLPPAADEQAVKSRVTAVFGQILQHVNDFYRNVHATLTPSMGNDLKKFCDSSVNLAEELEHSSMPTIAIKHALVGYLLSIIAPEAEQQSTLFPAEVAGLRQDERSFESPDDQAAYILYKRLAAHLYAPPISSLQSRQSDIREAAEHFALTFFPWANPAYADQDKDENLVDVINNALDLSLWLFGQPYLYEWVWEDVGRRGMVVSPGLVRVTDERGKMLDRPRKVVDAVVATS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CIS2</accession>
    <name>A0A177CIS2_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PCI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CC84DRAFT_1204540</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome subunit p55 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG06872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037237.1">
        <property type="nucleotide sequence ID" value="XM_018181911.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CIS2"/>
    <dbReference type="FunCoup" id="A0A177CIS2">
        <property type="interactions" value="1193"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CIS2"/>
    <dbReference type="GeneID" id="28765397"/>
    <dbReference type="InParanoid" id="A0A177CIS2"/>
    <dbReference type="OrthoDB" id="268763at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008180">
        <property type="term" value="C:COP9 signalosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034515">
        <property type="term" value="C:proteasome storage granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000338">
        <property type="term" value="P:protein deneddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000070">
        <property type="entry name" value="26S proteasome non-ATPase regulatory subunit 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054559">
        <property type="entry name" value="PSMD12-CSN4-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040134">
        <property type="entry name" value="PSMD12/CSN4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040896">
        <property type="entry name" value="RPN5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10855:SF1">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10855">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 12/COP9 SIGNALOSOME COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22241">
        <property type="entry name" value="PSMD12-CSN4_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18098">
        <property type="entry name" value="RPN5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0647">Proteasome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="4">
        <location>
            <begin position="267"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="208"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="212"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAG06872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="496" mass="56857" checksum="E57A908531F12DAD" modified="2016-09-07" version="1">MSSGQVHKADKDFTKEADKAIPEAEKLGSSNPQAAIEKLLLLEKQTRQASDLASTSRVLVAICTIAKNAGDWSLLNEQVLLLSKKHGQLKQATTKMVQTVMGFLDDTPSLETKLSVIETLRTVTEGKIFVEVERARITRILSNIKKEQGDITAATDILCELQVETFGSMTRREKTEFILQQVSLCIQKGDWTQAGILSRKISTRYFTRKPKKSPEQLEKEQKEREEKEKARSVDDPPVEPEDDVTDLKLRFYEQQITLAKHEDKYLDVCKHYRQVLDTEAVEEDPNKLKAILQRVIYFIILAPYDNEQSDLIHRIQRDSRNSMIPQDAQLVKLFTVPELMRWPMVAKQFGPHLTETDVFDAEADDSDDPKAYKRWQDLRKRVIEHNVRVVAKYYTRIQIPRLTELLDLTEDETEKYISELVTAKTIHAKIDRPARIVSFAKPRDADDVLNEWSGNMKSLLGLLERIDHLITKEEMMARIQGAKLDKSSKLAKGKAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CIU6</accession>
    <name>A0A177CIU6_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Mediator of RNA polymerase II transcription subunit 5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">Mediator complex subunit 5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">MED5</name>
        <name evidence="10" type="ORF">CC84DRAFT_1163449</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the Mediator complex subunit 5 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG07236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037601.1">
        <property type="nucleotide sequence ID" value="XM_018178266.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CIU6"/>
    <dbReference type="STRING" id="1460663.A0A177CIU6"/>
    <dbReference type="GeneID" id="28761752"/>
    <dbReference type="InParanoid" id="A0A177CIU6"/>
    <dbReference type="OrthoDB" id="5322661at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014801">
        <property type="entry name" value="Mediator_Med5_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35784">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35784:SF1">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08689">
        <property type="entry name" value="Med5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0010">Activator</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 9" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAG07236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="1035" mass="113634" checksum="D8D7C7F1AE57CF33" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CIV6</accession>
    <name>A0A177CIV6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">60S ribosomal protein L31</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_657298</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL31 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG07454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037819.1">
        <property type="nucleotide sequence ID" value="XM_018187041.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CIV6"/>
    <dbReference type="FunCoup" id="A0A177CIV6">
        <property type="interactions" value="886"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CIV6"/>
    <dbReference type="GeneID" id="28770527"/>
    <dbReference type="InParanoid" id="A0A177CIV6"/>
    <dbReference type="OrthoDB" id="9739313at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030684">
        <property type="term" value="C:preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00463">
        <property type="entry name" value="Ribosomal_L31e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.440.10:FF:000001">
        <property type="entry name" value="60S ribosomal protein L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000054">
        <property type="entry name" value="Ribosomal_eL31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023621">
        <property type="entry name" value="Ribosomal_eL31_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10956">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10956:SF0">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01198">
        <property type="entry name" value="Ribosomal_L31e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01380">
        <property type="entry name" value="Ribosomal_L31e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54575">
        <property type="entry name" value="Ribosomal protein L31e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAG07454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="129" mass="14501" checksum="C5D8436E8FD15D79" modified="2016-09-07" version="1">MSTAAKNSGKKPAGKTQRSAIADVVAREYTIHMHKRVHGVSFKKRAPRAIKEIRAFAEKAMGTKDVRLDPQLNKKVWESGIKGVPFRLRVRISRKRNDEEGAKEKLYSYVQAVNVKDPKGLQTTVVEDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CJ21</accession>
    <name>A0A177CJ21_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1143669</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG07261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037626.1">
        <property type="nucleotide sequence ID" value="XM_018176425.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CJ21"/>
    <dbReference type="STRING" id="1460663.A0A177CJ21"/>
    <dbReference type="GeneID" id="28759911"/>
    <dbReference type="InParanoid" id="A0A177CJ21"/>
    <dbReference type="OrthoDB" id="5377012at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="321"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="32"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="321"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG07261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="410" mass="42443" checksum="A4ADB70AE2D96647" modified="2016-09-07" version="1">MATAEPTSRPNERQARKRPFAGFMKRLANLNKSSSDSPSASSKKNQASTPSKSKKSAGKNNPYPESGHVSGNGNTNGNRLSFSSPVTPRSAESFTSVEEAHDADQHRALAKSNKSTAPTVATNPETVHSGRSKADTGFSNLGNNSTFSSPNHSERSLTTTLTTIQSTAPSNALGAGNAQTTQPANGPPVQFSHQFPTSPPPSAIPPHLVPQQSHPHSYQAATANNILTDNASILTLASSSKRRRRNSLDTNASVRALAPSSVWGGSRESLPLSVLSGTADTIYSPASRPGGVTGFANAERASVYSSSGVAAPALPSERNSYYANKQNTDGMSVRSGLLGHGRTDSISGSIGPNPASPLASPRETPGPAKLSRRSSDWQDGVEGSVGGDEADVPASPVSTEHNDKGNGNAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CJC5</accession>
    <name>A0A177CJC5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">DUF726-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CC84DRAFT_1143134</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMCO4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG06939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037304.1">
        <property type="nucleotide sequence ID" value="XM_018176396.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CJC5"/>
    <dbReference type="GeneID" id="28759882"/>
    <dbReference type="InParanoid" id="A0A177CJC5"/>
    <dbReference type="OrthoDB" id="277931at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007941">
        <property type="entry name" value="DUF726"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006785">
        <property type="entry name" value="Pex14_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17920:SF22">
        <property type="entry name" value="DUF726 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_2G12860)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17920">
        <property type="entry name" value="TRANSMEMBRANE AND COILED-COIL DOMAIN-CONTAINING PROTEIN 4 TMCO4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05277">
        <property type="entry name" value="DUF726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04695">
        <property type="entry name" value="Pex14_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="555"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="632"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="675"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="domain" description="Peroxisome membrane anchor protein Pex14p N-terminal" evidence="8">
        <location>
            <begin position="59"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="194"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="347"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="417"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="489"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="998"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1040"/>
            <end position="1076"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="49"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="209"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="237"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="355"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="439"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="502"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="998"/>
            <end position="1024"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1044"/>
            <end position="1067"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAG06939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="1076" mass="117196" checksum="E920BBC0BC57E02D" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CJM5</accession>
    <name>A0A177CJM5_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tRNA pseudouridine(55) synthase</fullName>
            <ecNumber evidence="3">5.4.99.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_1087936</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a uridine in mRNA = a pseudouridine in mRNA</text>
            <dbReference type="Rhea" id="RHEA:56644"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:14659"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the pseudouridine synthase TruB family.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.25" evidence="3"/>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG07030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037395.1">
        <property type="nucleotide sequence ID" value="XM_018174227.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CJM5"/>
    <dbReference type="FunCoup" id="A0A177CJM5">
        <property type="interactions" value="321"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CJM5"/>
    <dbReference type="GeneID" id="28757713"/>
    <dbReference type="InParanoid" id="A0A177CJM5"/>
    <dbReference type="OrthoDB" id="9995526at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160148">
        <property type="term" value="F:tRNA pseudouridine(55) synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990481">
        <property type="term" value="P:mRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2350.10">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01080">
        <property type="entry name" value="TruB_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002501">
        <property type="entry name" value="PsdUridine_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014780">
        <property type="entry name" value="tRNA_psdUridine_synth_TruB"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00431">
        <property type="entry name" value="TruB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13767:SF2">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE TRUB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13767">
        <property type="entry name" value="TRNA-PSEUDOURIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01509">
        <property type="entry name" value="TruB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Pseudouridine synthase II N-terminal" evidence="7">
        <location>
            <begin position="77"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="304"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="313"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAG07030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="379" mass="41725" checksum="A108F1A9CB4F96A3" modified="2016-09-07" version="1">MADGNSEVLEGIFALFKPSGITSGQALLHLQSIFSRSTLFAPLLASTRLNRAHQASLLPSGQKNKAEDEEANGRFFRMGHGGTLDPLASGILIVGIGRGTKALQNFLGCTKTYETVVLFGKSTDTHDVDGVVVAVKDCAHVSEELVSAKLAMFRGTFRQVPPVYSALKINGMKACEYMRAGKELPKELEDREVCVDECEMIEWWDGGKHEFKWPGDNVAAAAPAVRVRLTVSSGFYVRSFASDLGIACGSLATMAELVRTRQADFTTEERVDGQTLEAVTYADLDSSEDTWGPKVARQLRAWVQQNPPPAEYTHVDGRDPNTKKRLNEEEKTKVRQRFRGDWAGVSRKERRRQQKAAKEGMNGQKASNESINGHKDTTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CK38</accession>
    <name>A0A177CK38_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RAD52 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CC84DRAFT_1258332</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RAD52 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG07157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037522.1">
        <property type="nucleotide sequence ID" value="XM_018184818.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CK38"/>
    <dbReference type="STRING" id="1460663.A0A177CK38"/>
    <dbReference type="GeneID" id="28768304"/>
    <dbReference type="InParanoid" id="A0A177CK38"/>
    <dbReference type="OrthoDB" id="206565at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000730">
        <property type="term" value="P:DNA recombinase assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045002">
        <property type="term" value="P:double-strand break repair via single-strand annealing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006312">
        <property type="term" value="P:mitotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.390.80:FF:000001">
        <property type="entry name" value="DNA repair protein RAD52 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.80">
        <property type="entry name" value="DNA repair protein Rad52/59/22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004585">
        <property type="entry name" value="DNA_recomb/repair_Rad52"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041247">
        <property type="entry name" value="Rad52_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007232">
        <property type="entry name" value="Rad52_Rad59_Rad22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042525">
        <property type="entry name" value="Rad52_Rad59_Rad22_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00607">
        <property type="entry name" value="rad52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12132">
        <property type="entry name" value="DNA REPAIR AND RECOMBINATION PROTEIN RAD52, RAD59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12132:SF1">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD52 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04098">
        <property type="entry name" value="Rad52_Rad22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="263"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="265"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="283"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="302"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="331"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="371"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="387"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="473"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="514"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00077224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAG07157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="574" mass="61292" checksum="F44FC6F1AA4BE8AD" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CKL7</accession>
    <name>A0A177CKL7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_521631</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG07846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038211.1">
        <property type="nucleotide sequence ID" value="XM_018186609.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CKL7"/>
    <dbReference type="GeneID" id="28770095"/>
    <dbReference type="InParanoid" id="A0A177CKL7"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG07846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="114" mass="12500" checksum="6CF3F1AF7A2481EE" modified="2016-09-07" version="1">MQLPSQAWVSPLLVSCAGSCELRARMFRVCYFASAWYGERSLTCTARRTASRGRCIPTCQADLTGQHKPRPPQLIYASNLQPSSAVSLPPTARARPAIRDTPSGLSRPDLHSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CKV3</accession>
    <name>A0A177CKV3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1204953</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG07480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037845.1">
        <property type="nucleotide sequence ID" value="XM_018181941.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CKV3"/>
    <dbReference type="STRING" id="1460663.A0A177CKV3"/>
    <dbReference type="GeneID" id="28765427"/>
    <dbReference type="InParanoid" id="A0A177CKV3"/>
    <dbReference type="OrthoDB" id="5343383at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42029">
        <property type="entry name" value="AN04G07800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42029:SF3">
        <property type="entry name" value="AN04G07800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG07480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="301" mass="34064" checksum="3328E5C9843FC5E7" modified="2016-09-07" version="1">MDSSYSRDDCVAAIRDYYAFLAAMFMDPSYIIEPPPDGWPNMTAEAMQELGKSRKPGPGPPDPEGLPGGSFIDWRHIVDQMKEGEADAALELLGSQGEKRQFGGKLPKSCIGLVRGGLLMGEDPDVIVLDTADRLVYWMTCPAVIKEISEPKPTYFVGSVDGEETETNGNASGEEDVDENVDQINEDDEDEEDDEDDDLDDFIRWGPCWPFRDFFEMLKSQFRELNFFAKDAYQVVDKWTNTTPIDGPILEGLVAMVQAIYRRHGWPDVSQYRKEECLAEIKKELDEKFPRHAGYYDRCLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CKZ2</accession>
    <name>A0A177CKZ2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CC84DRAFT_1238904</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Putative oxidoreductase.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG07891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038256.1">
        <property type="nucleotide sequence ID" value="XM_018183967.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CKZ2"/>
    <dbReference type="STRING" id="1460663.A0A177CKZ2"/>
    <dbReference type="GeneID" id="28767453"/>
    <dbReference type="InParanoid" id="A0A177CKZ2"/>
    <dbReference type="OrthoDB" id="37659at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44196">
        <property type="entry name" value="DEHYDROGENASE/REDUCTASE SDR FAMILY MEMBER 7B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44196:SF1">
        <property type="entry name" value="DEHYDROGENASE_REDUCTASE SDR FAMILY MEMBER 7B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00037096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAG07891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="273" mass="29484" checksum="2E6325C93D1CCCE1" modified="2016-09-07" version="1">MTSRINTILIIGGTTGIGEQLVRRFHALDKKVIVTGRNQASLTSLAQALNGLETRQFDITDFSNLQSHVAGILKDFPSLDTVLINAGIQKSFSFFDPSSIAAGEIEREIAANLTAPTLLVQAFAPHLLSLASKGTPATLFVTSSTLGLLPMGLWANYSATKAGVHALALSLRQQIAFASEEAKKNFNVVEIVPPYVDTGLDKEHREATLAAMGERAFPPMPLQEYIDQFFNALDEIELDGSLKKEIGVGTGAMAVQTWRESLGKVYEQFGMAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CKZ3</accession>
    <name>A0A177CKZ3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_1162201</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HesB/IscA family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038579.1">
        <property type="nucleotide sequence ID" value="XM_018177938.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CKZ3"/>
    <dbReference type="FunCoup" id="A0A177CKZ3">
        <property type="interactions" value="279"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CKZ3"/>
    <dbReference type="GeneID" id="28761424"/>
    <dbReference type="InParanoid" id="A0A177CKZ3"/>
    <dbReference type="OrthoDB" id="1938621at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.300.12">
        <property type="entry name" value="HesB-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016092">
        <property type="entry name" value="ATAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000361">
        <property type="entry name" value="ATAP_core_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035903">
        <property type="entry name" value="HesB-like_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00049">
        <property type="entry name" value="iron-sulfur cluster assembly accessory protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43011">
        <property type="entry name" value="IRON-SULFUR CLUSTER ASSEMBLY 2 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43011:SF1">
        <property type="entry name" value="IRON-SULFUR CLUSTER ASSEMBLY 2 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01521">
        <property type="entry name" value="Fe-S_biosyn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89360">
        <property type="entry name" value="HesB-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core" evidence="3">
        <location>
            <begin position="95"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="63"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAG08214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="210" mass="22334" checksum="9204DA4F7E4A262D" modified="2016-09-07" version="1">MCTSCLRAARASRAFSTAPPAYSAASATSRPLFLDFLEPAIRLPCTRPAGIALPRPQATLRRRLATAASPPTSPSDPQPARAVLNPRTTDSGEPMRISLSPRAIHRLSTIATKDNNPNLALRVTIESGGCHGFQYLMSLIDLTKEPPTEEDTLFEGDKGAKVIVDESSLELLNGSTVDYTMELIGSQFKVTGIPGATSSCGCGTSFDIKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CL98</accession>
    <name>A0A177CL98_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Insect inhibitor with A fungal trypsin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_1239231</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038441.1">
        <property type="nucleotide sequence ID" value="XM_018183972.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CL98"/>
    <dbReference type="STRING" id="1460663.A0A177CL98"/>
    <dbReference type="GeneID" id="28767458"/>
    <dbReference type="InParanoid" id="A0A177CL98"/>
    <dbReference type="OrthoDB" id="6380398at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000077">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252">
        <property type="entry name" value="ACROSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252:SF7">
        <property type="entry name" value="HYALIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 5" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0720">Serine protease</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008058356" evidence="6">
        <location>
            <begin position="28"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="7">
        <location>
            <begin position="34"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAG08076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="265" mass="26266" checksum="D90BDEFEFF5AF80C" modified="2016-09-07" version="1">MAIKSFLTAALVAPAAVFGAAIPPTEAGTSSINIVGGEAASAGDFPFIVSLQVSGSHFCGGSLLNANTVVTAGHCGVAYAASRVTVRAGSLNRNSGGTVVSVSSIKTYSGFNSNTLDGDVSILKLATSIPTSSTISYATLAASGSDPASGTTLTVAGWGTTTEGGSSLPTALRKVSVPVVARDTCASQYKAIDQSYTITTNMFCAGLAAGGKDSCQGDSGGPIVDSSKTLVGLVSWGEGCAEPNAPGVYTRVGSSVIRSFITSNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CLB3</accession>
    <name>A0A177CLB3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1162272</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038668.1">
        <property type="nucleotide sequence ID" value="XM_018177950.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CLB3"/>
    <dbReference type="GeneID" id="28761436"/>
    <dbReference type="InParanoid" id="A0A177CLB3"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG08303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="108" mass="11613" checksum="B4103D6F3496054E" modified="2016-09-07" version="1">MAITHQPVLFVGLYRERNRNLQRTRKHGCRIPQKPLSALASAPATGLMLAFGTGCSSLAVPIGSGWSLKACARRVILAVFAVMRLTCASILLPREADAGCGYAIFKVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CM35</accession>
    <name>A0A177CM35_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">3-dehydroshikimate dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1162336</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038731.1">
        <property type="nucleotide sequence ID" value="XM_018177964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CM35"/>
    <dbReference type="STRING" id="1460663.A0A177CM35"/>
    <dbReference type="GeneID" id="28761450"/>
    <dbReference type="InParanoid" id="A0A177CM35"/>
    <dbReference type="OrthoDB" id="5360893at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.150">
        <property type="entry name" value="Divalent-metal-dependent TIM barrel enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050312">
        <property type="entry name" value="IolE/XylAMocC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12110">
        <property type="entry name" value="HYDROXYPYRUVATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12110:SF21">
        <property type="entry name" value="XYLOSE ISOMERASE-LIKE TIM BARREL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="Xylose isomerase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylose isomerase-like TIM barrel" evidence="1">
        <location>
            <begin position="18"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG08366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="357" mass="40178" checksum="36FE055370BBFA3C" modified="2016-09-07" version="1">MSLGRCYAGHSMEHKLSMAAKHGLQGIELFYEDLADLAEPPTPSNLLSAAAYVRSLCTSLGLGIICLQPFMHYEGLLDRSKHAKRIEEIHLWIQLAKVLDTDLIQVPSTFLAAEEISDDVKLILSDLRELADIGLQHSPPIRFAYESLCWGTYVDKWELCWDIVTRVDRPNFGICLDSFNILGRIYADPTSPTGCNAGAEEEVQASIRRLVQQIGPHKEKIFFFQVVDAERLEKPLLPGHAFYNAAQPARMSWSRNCRLFYGETAHGAYLPVRDVAHAIIKEIGFEGWVSMELFNRAMERKDEGVVEELASRAGESWRRMVVDLGMEAEAEEVRKKSIVRTDSGTDIVEREAGLARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CNF9</accession>
    <name>A0A177CNF9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DNA mismatch repair proteins mutS family domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CC84DRAFT_1142274</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA mismatch repair MutS family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG09075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039440.1">
        <property type="nucleotide sequence ID" value="XM_018176358.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CNF9"/>
    <dbReference type="FunCoup" id="A0A177CNF9">
        <property type="interactions" value="23"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CNF9"/>
    <dbReference type="GeneID" id="28759844"/>
    <dbReference type="InParanoid" id="A0A177CNF9"/>
    <dbReference type="OrthoDB" id="2534523at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043504">
        <property type="term" value="P:mitochondrial DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001238">
        <property type="entry name" value="DNA mismatch repair protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1420.10:FF:000036">
        <property type="entry name" value="DNA mismatch repair protein Msh1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1420.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.10">
        <property type="entry name" value="DNA repair protein MutS, domain I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.110">
        <property type="entry name" value="MutS, connector domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007695">
        <property type="entry name" value="DNA_mismatch_repair_MutS-lik_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017261">
        <property type="entry name" value="DNA_mismatch_repair_MutS/MSH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007696">
        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016151">
        <property type="entry name" value="DNA_mismatch_repair_MutS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007860">
        <property type="entry name" value="DNA_mmatch_repair_MutS_con_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036678">
        <property type="entry name" value="MutS_con_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361:SF34">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MSH1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01624">
        <property type="entry name" value="MutS_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05188">
        <property type="entry name" value="MutS_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05192">
        <property type="entry name" value="MutS_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037677">
        <property type="entry name" value="DNA_mis_repair_Msh6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00533">
        <property type="entry name" value="MUTSd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55271">
        <property type="entry name" value="DNA repair protein MutS, domain I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53150">
        <property type="entry name" value="DNA repair protein MutS, domain II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="DNA repair protein MutS, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00486">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair proteins mutS family" evidence="9">
        <location>
            <begin position="890"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="20"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1003"/>
            <end position="1022"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="631"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS00486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAG09075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="1022" mass="113656" checksum="680458E68A80280F" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CNN1</accession>
    <name>A0A177CNN1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein transport protein SEC9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_1195076</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SNAP-25 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG09145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039510.1">
        <property type="nucleotide sequence ID" value="XM_018181387.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CNN1"/>
    <dbReference type="FunCoup" id="A0A177CNN1">
        <property type="interactions" value="119"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CNN1"/>
    <dbReference type="GeneID" id="28764873"/>
    <dbReference type="InParanoid" id="A0A177CNN1"/>
    <dbReference type="OrthoDB" id="18679at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005628">
        <property type="term" value="C:prospore membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032120">
        <property type="term" value="P:ascospore-type prospore membrane formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15857">
        <property type="entry name" value="SNARE_SEC9C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15886">
        <property type="entry name" value="SNARE_SEC9N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000043">
        <property type="entry name" value="Protein transport protein sec9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000048">
        <property type="entry name" value="Protein transport protein SEC9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19305">
        <property type="entry name" value="SYNAPTOSOMAL ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19305:SF9">
        <property type="entry name" value="SYNAPTOSOMAL-ASSOCIATED PROTEIN 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="7">
        <location>
            <begin position="337"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="225"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="13"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="69"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="115"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="147"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00072549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAG09145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="400" mass="43306" checksum="CD8F2654545DB65F" modified="2016-09-07" version="1">MGLFKKKNKEADAAANPYAAPAKNDLYASAPPPAYQGGNDSFRQEKTPAVTGQGAQFGGRGYQSTGSYGASGGYGGNQYGGGADQGAPRRTGGYGGLGNSDPNLDEDRSALFGGAAQRQPKAPQQQPPQSDGGYGQPGGSSYSQSGVSGGGYGAPGGYGSGPAYEDRQLTAEEQEEEDIMATKNEIKFMKQQDVSSTRNALRLAQQAEETGRDTLARLGAQGERIHNTERNLDLASSQNRIAEEKARELKTLNRSMFAVHVSNPFTSNSRREERDRKIMENHQTERAQRDATRAAAWQSSARQDEYKRGVQGAANTGGKSTLADRAKYQFEADSEDDEMENEIDNNLDQLHGAAKRLNALGRAMGQEVDTQNKHIDRITQKTDKVDDQIAMNRARLDRIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CNS1</accession>
    <name>A0A177CNS1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1162497</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038933.1">
        <property type="nucleotide sequence ID" value="XM_018178008.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CNS1"/>
    <dbReference type="GeneID" id="28761494"/>
    <dbReference type="InParanoid" id="A0A177CNS1"/>
    <dbReference type="OrthoDB" id="5281164at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG08568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="291" mass="33228" checksum="475679235552F812" modified="2016-09-07" version="1">MNTSDNWSARNWQDPRIDTKNQRIAALLVPPGPLGPFHPAHRYVPHPAETPLQSTTPLLRFPTELHLEIFGHIRADGDTFEDTRLMSESRAKQVFGDPHAWLWTVLALRGTSRLFRYMLPPLTHDELLDLELTLRATSRGLQACRYCLCLRHTSHFSHAQTRQRGVPIDAVLGWAGYSVKSREKRAKRFCVDCGFAKAINPELDIGKVRYGKGSDVVVGESEGERWVWCWWCEKLKRGKEAGMLGKEACTGSCVSCCEKRACKGACVREEQDRRRTAAEEWIIERRELELD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CP40</accession>
    <name>A0A177CP40_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PhoD-like phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1162613</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039107.1">
        <property type="nucleotide sequence ID" value="XM_018178040.1"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CP40"/>
    <dbReference type="GeneID" id="28761526"/>
    <dbReference type="InParanoid" id="A0A177CP40"/>
    <dbReference type="OrthoDB" id="9999821at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07389">
        <property type="entry name" value="MPP_PhoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.70">
        <property type="entry name" value="PhoD-like phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018946">
        <property type="entry name" value="PhoD-like_MPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038607">
        <property type="entry name" value="PhoD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043904">
        <property type="entry name" value="PhoD_2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46689">
        <property type="entry name" value="MEMBRANE PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46689:SF1">
        <property type="entry name" value="PHOD-LIKE PHOSPHATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19050">
        <property type="entry name" value="PhoD_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PhoD-like phosphatase" evidence="2">
        <location>
            <begin position="788"/>
            <end position="1048"/>
        </location>
    </feature>
    <feature type="domain" description="PhoD-like phosphatase" evidence="2">
        <location>
            <begin position="1056"/>
            <end position="1216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="232"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="399"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="544"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="713"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1212"/>
            <end position="1339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1395"/>
            <end position="1589"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1608"/>
            <end position="1726"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="46"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="400"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="436"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="457"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="713"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1217"/>
            <end position="1226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1311"/>
            <end position="1321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1427"/>
            <end position="1438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1439"/>
            <end position="1452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1562"/>
            <end position="1573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1576"/>
            <end position="1588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1620"/>
            <end position="1629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1644"/>
            <end position="1655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1716"/>
            <end position="1726"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG08742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="1726" mass="190856" checksum="0EB04B9D20712581" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CPF8</accession>
    <name>A0A177CPF8_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_1240023</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039022.1">
        <property type="nucleotide sequence ID" value="XM_018184002.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CPF8"/>
    <dbReference type="GeneID" id="28767488"/>
    <dbReference type="InParanoid" id="A0A177CPF8"/>
    <dbReference type="OrthoDB" id="4222821at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="5"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="52"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="58"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAG08657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="214" mass="23575" checksum="D002089272FBDDE8" modified="2016-09-07" version="1">MKQTVCDRCHGQKLKCEFANGGTGDSCKRCTRAGAKCTYPTYEECVPNQIEDQGRPNAAQNQMTNARGTNRSESLPTHPRLNSHRHRSFTTLASPRLDRGPSQAQMSRKRLRSSMEGLASSYPYPMTTASEQSLDAALSQEALDHVATAPAHDVLNIPFDFTWSDVEILQLDGLASDSLREAYPDGSPRYMPHLHDRSDGPVSVAVVGSYEGLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CQI3</accession>
    <name>A0A177CQI3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Initiator tRNA phosphoribosyl transferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_1136658</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG09208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039573.1">
        <property type="nucleotide sequence ID" value="XM_018176108.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CQI3"/>
    <dbReference type="FunCoup" id="A0A177CQI3">
        <property type="interactions" value="55"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CQI3"/>
    <dbReference type="GeneID" id="28759594"/>
    <dbReference type="InParanoid" id="A0A177CQI3"/>
    <dbReference type="OrthoDB" id="45256at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043399">
        <property type="term" value="F:tRNA adenosine(64)-2'-O-ribosylphosphate transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019988">
        <property type="term" value="P:charged-tRNA amino acid modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045632">
        <property type="entry name" value="DUF6314"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007306">
        <property type="entry name" value="Rit1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033421">
        <property type="entry name" value="Rit1_DUSP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033449">
        <property type="entry name" value="Rit1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31811">
        <property type="entry name" value="TRNA A64-2'-O-RIBOSYLPHOSPHATE TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31811:SF0">
        <property type="entry name" value="TRNA A64-2'-O-RIBOSYLPHOSPHATE TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19834">
        <property type="entry name" value="DUF6314"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04179">
        <property type="entry name" value="Init_tRNA_PT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17184">
        <property type="entry name" value="Rit1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rit1 N-terminal" evidence="2">
        <location>
            <begin position="26"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="Rit1 DUSP-like" evidence="1">
        <location>
            <begin position="336"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6314" evidence="3">
        <location>
            <begin position="487"/>
            <end position="655"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAG09208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="660" mass="72297" checksum="7F566450BCFBE213" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CQL3</accession>
    <name>A0A177CQL3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1174421</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG09047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039412.1">
        <property type="nucleotide sequence ID" value="XM_018180094.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CQL3"/>
    <dbReference type="GeneID" id="28763580"/>
    <dbReference type="InParanoid" id="A0A177CQL3"/>
    <dbReference type="OrthoDB" id="10482930at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG09047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="156" mass="16401" checksum="0BD2557E49DD0078" modified="2016-09-07" version="1">MACRGFRDAGSQCGSRAQMVARAGPSSLGPATLRREGVEGVKVGGPCAKILPQGLGRTRRIRQRALSHRRTQVGKRTQRVAAGGSPRCLVGVTRQVGRGALEGLVDKARARVRPGSLQTSAMAIRRLPALEFGGDLKMAAAVFRWSSGCTSSDCSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CQX7</accession>
    <name>A0A177CQX7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mitotic-spindle organizing protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Mitotic-spindle organizing protein associated with a ring of gamma-tubulin 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CC84DRAFT_1160959</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for gamma-tubulin complex recruitment to the microtubule organizing center (MTOC).</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the gamma-tubulin complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Microtubule organizing center</location>
            <location evidence="2">Spindle pole body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the MOZART1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG09923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040288.1">
        <property type="nucleotide sequence ID" value="XM_018177624.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CQX7"/>
    <dbReference type="STRING" id="1460663.A0A177CQX7"/>
    <dbReference type="GeneID" id="28761110"/>
    <dbReference type="InParanoid" id="A0A177CQX7"/>
    <dbReference type="OrthoDB" id="48571at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000931">
        <property type="term" value="C:gamma-tubulin ring complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031021">
        <property type="term" value="C:interphase microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033566">
        <property type="term" value="P:gamma-tubulin complex localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051415">
        <property type="term" value="P:microtubule nucleation by interphase microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090307">
        <property type="term" value="P:mitotic spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022214">
        <property type="entry name" value="MZT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28520">
        <property type="entry name" value="MITOTIC-SPINDLE ORGANIZING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28520:SF2">
        <property type="entry name" value="MITOTIC-SPINDLE ORGANIZING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12554">
        <property type="entry name" value="MOZART1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAG09923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="81" mass="8815" checksum="98D5595F1480C826" modified="2016-09-07" version="1">MPADAAPPQDVKRKAAREVIDILHEIATLLNTKLDRQQLSYCVSLIENGANPEALANVIRELREEYGTDSVDGGAEEPGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CRU8</accession>
    <name>A0A177CRU8_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1172058</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG09489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039854.1">
        <property type="nucleotide sequence ID" value="XM_018179953.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CRU8"/>
    <dbReference type="STRING" id="1460663.A0A177CRU8"/>
    <dbReference type="GeneID" id="28763439"/>
    <dbReference type="InParanoid" id="A0A177CRU8"/>
    <dbReference type="OrthoDB" id="5062908at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059009">
        <property type="entry name" value="Znf_C2H2_17_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059095">
        <property type="entry name" value="Znf_C2H2_17_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26177">
        <property type="entry name" value="zf_C2H2_17_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26176">
        <property type="entry name" value="zf_C2H2_17_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="424"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="460"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="137"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG09489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="606" mass="67378" checksum="1F5E7D6C24CD8AA6" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CS65</accession>
    <name>A0A177CS65_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cloroperoxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CC84DRAFT_482663</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the chloroperoxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040739.1">
        <property type="nucleotide sequence ID" value="XM_018186451.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CS65"/>
    <dbReference type="STRING" id="1460663.A0A177CS65"/>
    <dbReference type="GeneID" id="28769937"/>
    <dbReference type="InParanoid" id="A0A177CS65"/>
    <dbReference type="OrthoDB" id="407298at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.489.10">
        <property type="entry name" value="Chloroperoxidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000028">
        <property type="entry name" value="Chloroperoxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036851">
        <property type="entry name" value="Chloroperoxidase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33577:SF9">
        <property type="entry name" value="PEROXIDASE STCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33577">
        <property type="entry name" value="STERIGMATOCYSTIN BIOSYNTHESIS PEROXIDASE STCC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01328">
        <property type="entry name" value="Peroxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47571">
        <property type="entry name" value="Cloroperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51405">
        <property type="entry name" value="HEME_HALOPEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 10" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008058548" evidence="8">
        <location>
            <begin position="17"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="Heme haloperoxidase family profile" evidence="9">
        <location>
            <begin position="19"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAG10374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="256" mass="27484" checksum="FC8CA718257350D6" modified="2016-09-07" version="1">MKIVTTILGLTAVAGAQFNYDDWRAPASGDLRSPCPVLNALANHGFLPRDGRNITQGVLIKATSAVNLSTEVTVGLFLAALKTSSDPASGAFTLQDLKKHNIIEHDGSLSRADTGTPGAGDQEFNRDVFNEFKSFFKGATQISLPLAAAARWARVKSAHKSNPNFLYGPSQRFNSYAETSIYFQLLLDPNKGTVPLEWLEIVFCEERLPAREGWKTPSSINGLGTGGVLLKLAMATDEKDADIVLPGTGNVISHPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CSB5</accession>
    <name>A0A177CSB5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CC84DRAFT_1235376</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG09649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040014.1">
        <property type="nucleotide sequence ID" value="XM_018183845.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CSB5"/>
    <dbReference type="STRING" id="1460663.A0A177CSB5"/>
    <dbReference type="GeneID" id="28767331"/>
    <dbReference type="InParanoid" id="A0A177CSB5"/>
    <dbReference type="OrthoDB" id="1103324at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11065">
        <property type="entry name" value="CYP64-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF2">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE ALNH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0349">Heme</keyword>
    <keyword evidence="4 6" id="KW-0408">Iron</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="6">
        <location>
            <position position="415"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAG09649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="498" mass="56624" checksum="4F0059C4CA8CA82A" modified="2016-09-07" version="1">MRTLRLTKNFTKGWCSGSVFCVLLLTQGRFKDWSEQYGDVFSLKIGKGTMIVLNSKRAVYELIDKRSAIYSSRANDEQFRTALKNENIANMDADAGWRAQRKITARFLAPAKLDGELAKISEAEITTLMHDLIVSPEDFSKHINRSSASFSAIALYGQRATTHDVFWATFVYEAMDVMNKVVSPGTYLPSEQFPIFKLLPKRWNPAHARAEESFRFCTGLFTEAQKRVEARRSQGDKRTSLMDELLDENTRSDTSFTGTKLANFLGALMEGAADTGALSMRTNIMFLATHPWVQDKAQKELDTLCGADRMPTWADFKDLPYINCIMKEGLRIRPVVPTGIPHACTQDNWYEGMLIPKDATIMIPLWALHHSQYDDPDTYNPDRYLNHPGLASEYAASHDYQNRDHYSYGAGRRICPGIQLAERTQFRMLSAMLWAFRLEHAIDEKTGKEIPIDTEAFEDKLITGPKAFQVRFTPRSLKHVEVIKKELGNVSGLLKTWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CSC5</accession>
    <name>A0A177CSC5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RNI-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1213463</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040466.1">
        <property type="nucleotide sequence ID" value="XM_018182535.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CSC5"/>
    <dbReference type="FunCoup" id="A0A177CSC5">
        <property type="interactions" value="268"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CSC5"/>
    <dbReference type="GeneID" id="28766021"/>
    <dbReference type="InParanoid" id="A0A177CSC5"/>
    <dbReference type="OrthoDB" id="8436363at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="291"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="944"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1030"/>
            <end position="1094"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="149"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="291"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="308"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="357"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="949"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1033"/>
            <end position="1061"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG10101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="1227" mass="133110" checksum="C9E7FB4BBF2DA022" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CSH0</accession>
    <name>A0A177CSH0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Spc7-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_1139090</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040849.1">
        <property type="nucleotide sequence ID" value="XM_018176225.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CSH0"/>
    <dbReference type="STRING" id="1460663.A0A177CSH0"/>
    <dbReference type="GeneID" id="28759711"/>
    <dbReference type="InParanoid" id="A0A177CSH0"/>
    <dbReference type="OrthoDB" id="5592879at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990758">
        <property type="term" value="P:mitotic sister chromatid biorientation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007094">
        <property type="term" value="P:mitotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034501">
        <property type="term" value="P:protein localization to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040850">
        <property type="entry name" value="Knl1_RWD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033338">
        <property type="entry name" value="Spc105/Spc7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013253">
        <property type="entry name" value="Spc7_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28260">
        <property type="entry name" value="SPINDLE POLE BODY COMPONENT SPC105"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28260:SF1">
        <property type="entry name" value="SPINDLE POLE BODY COMPONENT SPC105"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18210">
        <property type="entry name" value="Knl1_RWD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15402">
        <property type="entry name" value="MELT_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08317">
        <property type="entry name" value="Spc7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00787">
        <property type="entry name" value="Spc7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01315">
        <property type="entry name" value="Spc7_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Spc7 kinetochore protein" evidence="3">
        <location>
            <begin position="715"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="275"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="313"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="481"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="528"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="649"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="897"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="29"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="86"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="172"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="188"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="359"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="439"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="455"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="493"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="571"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="664"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="682"/>
            <end position="698"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAG10484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="1217" mass="135697" checksum="E1271E922DDF77B0" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CSX3</accession>
    <name>A0A177CSX3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosomal protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CC84DRAFT_1213720</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the bacterial ribosomal protein bL36 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040761.1">
        <property type="nucleotide sequence ID" value="XM_018182566.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CSX3"/>
    <dbReference type="FunCoup" id="A0A177CSX3">
        <property type="interactions" value="198"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CSX3"/>
    <dbReference type="GeneID" id="28766052"/>
    <dbReference type="InParanoid" id="A0A177CSX3"/>
    <dbReference type="OrthoDB" id="10265903at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000473">
        <property type="entry name" value="Ribosomal_bL36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035977">
        <property type="entry name" value="Ribosomal_bL36_sp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052010">
        <property type="entry name" value="Ribosomal_LSU_bL36"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01022">
        <property type="entry name" value="rpmJ_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18804">
        <property type="entry name" value="RIBOSOMAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18804:SF16">
        <property type="entry name" value="RIBOSOMAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00444">
        <property type="entry name" value="Ribosomal_L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57840">
        <property type="entry name" value="Ribosomal protein L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAG10396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="122" mass="13513" checksum="8A724CE392BD963D" modified="2016-09-07" version="1">MLAQTLLLPLRRTFLSAATPARLPTISRALHTPAARPCLQSSPAMASLSSRFAGLRIQQQTRGMKVRSSVKKLCDGCKSVRRKKGKYVYIICSKNPKHKQRYVPSLSFWDWELGLGGSAGPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CTA9</accession>
    <name>A0A177CTA9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_460088</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040382.1">
        <property type="nucleotide sequence ID" value="XM_018186367.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CTA9"/>
    <dbReference type="GeneID" id="28769853"/>
    <dbReference type="InParanoid" id="A0A177CTA9"/>
    <dbReference type="OrthoDB" id="3734023at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG10017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="303" mass="35266" checksum="B68DDC03A3055CC2" modified="2016-09-07" version="1">MMPGPSWPTSALHNADLLYKLPRELRDKVYVDVLNADCPVGLTEDLLPHIPPILRGNPDLLPEALEMLTKTQTFTWDFDDPRIYPLVWTRECVQPYDVRHLDITCSEYMEHFGLDGLEEHENMYRDSVPRVLWERLMQFPRLQNLTIYMQKNMEPKALNTLDFGPVLYNLRAKLSKINIKFFLSFDEMLLGLWNGPMESDDDLSADVSPYQPMGFVNMSDLIAPPNAEDVAYVQEYLPEYMNTGRMPHSRRISTGLIDESPASRRALAQHYAVTEPALLRCLMRDHFEIYRKRQDRVPEEEST</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CUF7</accession>
    <name>A0A177CUF7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glucanase</fullName>
            <ecNumber evidence="3">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_1256617</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase family 6.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="3"/>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041241.1">
        <property type="nucleotide sequence ID" value="XM_018184639.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CUF7"/>
    <dbReference type="STRING" id="1460663.A0A177CUF7"/>
    <dbReference type="GeneID" id="28768125"/>
    <dbReference type="InParanoid" id="A0A177CUF7"/>
    <dbReference type="OrthoDB" id="64893at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.40">
        <property type="entry name" value="1, 4-beta cellobiohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016288">
        <property type="entry name" value="Beta_cellobiohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036434">
        <property type="entry name" value="Beta_cellobiohydrolase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34876">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34876:SF2">
        <property type="entry name" value="GLUCANASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01341">
        <property type="entry name" value="Glyco_hydro_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001100">
        <property type="entry name" value="Beta_cellobiohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00733">
        <property type="entry name" value="GLHYDRLASE6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51989">
        <property type="entry name" value="Glycosyl hydrolases family 6, cellulases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007948985" description="Glucanase" evidence="3">
        <location>
            <begin position="17"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="165"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="366"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="210"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="326"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR001100-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR001100-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAG10876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="435" mass="48031" checksum="91F5903B1FFD7A63" modified="2016-09-07" version="1">MITAFCLTVLWAGVGAFPSKGEQPLAACAEPVALNASTNIWLSYTLHPHSIYRPYYAAAAGIVNDTVLKDKAIKVAETGTFLWIESNDDILKIDQAIQDVPCGNVLGLVINGLSHAGCDETIGETPGAKGTKRQSESYLESFIAPIARRIQQYQNTAFALIIEPDILPFVVRNPYYKECTTSQLEYRSSIPQALKALDLPNTITYLDAKHAGWFGWNPNRTPYDTKNIARELTVAWERAGGAALKQFRGVSVNVKSYNSWDMSPGEAFRDESAVCADLFNKARNEQRYVALLGQSFKAINSTFPLHAIFDSSRSGVQSIRQYWHDWCNNKWAGLGPRPTLELQRRVHARDPNFDAFVWATPVGFSDGTSEVGGLGWHANCSSEVAYIPMPEKGAFSQNYFETLLRSSRGVKSRGFGNGVVGGEQGVKLERRCDGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CV91</accession>
    <name>A0A177CV91_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CNVH-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1161662</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041177.1">
        <property type="nucleotide sequence ID" value="XM_018177798.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CV91"/>
    <dbReference type="GeneID" id="28761284"/>
    <dbReference type="InParanoid" id="A0A177CV91"/>
    <dbReference type="OrthoDB" id="2107166at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.60.10">
        <property type="entry name" value="Cyanovirin-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011058">
        <property type="entry name" value="Cyanovirin-N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036673">
        <property type="entry name" value="Cyanovirin-N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37014">
        <property type="entry name" value="EXPRESSION LETHALITY PROTEIN HEL10, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G06580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37014:SF1">
        <property type="entry name" value="EXPRESSION LETHALITY PROTEIN HEL10, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G06580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08881">
        <property type="entry name" value="CVNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01111">
        <property type="entry name" value="CVNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51322">
        <property type="entry name" value="Cyanovirin-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LysM" evidence="2">
        <location>
            <begin position="249"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="27"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG10812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="354" mass="38311" checksum="3C71FE7874946D4A" modified="2016-09-07" version="1">MYNNNNNNGYQQQGGYQQDSRQGLANEYYSEGQGQQYGGNQQSYNQPPPQYQQQTLQYGQQPQHHGGYNSPPPNESYGQRDNRDPEYGAPPSTDGQETSRGFLGAAAGAAVGGYGAYKLAGPATGHSKTSGLVGALGGALTGHVIQNGASHWKDKRDEKKEKEKWEKDEKQNGGRRDSNEHRLGGNFAGGFTRSSRDVRLDAHGEFNLHAQCRREDGSWQGSTLSLNRILENDDGSFRWSSGRPSGGSSAITVQAGDTLRAIAARHNCDFHELARHNGIQNEDMIYPGQRLEVPGGGYSGGGGAANFGASARNVRLVEGGQVLEGELRRGGDWVTSRIVLDERIGNKNGCLELV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CWI3</accession>
    <name>A0A177CWI3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cytochrome b-c1 complex subunit 6, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Complex III subunit 6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CC84DRAFT_1133990</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UQCRH/QCR6 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG11873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042238.1">
        <property type="nucleotide sequence ID" value="XM_018176005.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CWI3"/>
    <dbReference type="STRING" id="1460663.A0A177CWI3"/>
    <dbReference type="GeneID" id="28759491"/>
    <dbReference type="InParanoid" id="A0A177CWI3"/>
    <dbReference type="OrthoDB" id="405848at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006122">
        <property type="term" value="P:mitochondrial electron transport, ubiquinol to cytochrome c"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.20:FF:000003">
        <property type="entry name" value="Cytochrome b-c1 complex subunit 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.20">
        <property type="entry name" value="Ubiquinol-cytochrome C reductase hinge domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003422">
        <property type="entry name" value="Cyt_b-c1_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023184">
        <property type="entry name" value="Ubol_cytC_Rdtase_hinge_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036811">
        <property type="entry name" value="Ubol_cytC_Rdtase_hinge_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15336:SF0">
        <property type="entry name" value="CYTOCHROME B-C1 COMPLEX SUBUNIT 6, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15336">
        <property type="entry name" value="UBIQUINOL-CYTOCHROME C REDUCTASE COMPLEX 7.8 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02320">
        <property type="entry name" value="UCR_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81531">
        <property type="entry name" value="Non-heme 11 kDa protein of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Ubiquinol-cytochrome C reductase hinge" evidence="12">
        <location>
            <begin position="81"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="14"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="27"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="68"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OAG11873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="148" mass="16197" checksum="EDF92CB4A77CE869" modified="2016-09-07" version="1">MGITDFFSDVWETFSYPSPDAEAPPQGGSSTESPASGTDEESDAEKEANKEDAKEEGEGEQGHMPSGGDDEEEEEEEEPQDPKDILEKECAESKACHGPKHHYDECVERVTGQIENDGKASEDCVEEFFHLAHCATQCAAPKLFAQLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CWX1</accession>
    <name>A0A177CWX1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1159429</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042410.1">
        <property type="nucleotide sequence ID" value="XM_018177229.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CWX1"/>
    <dbReference type="GeneID" id="28760715"/>
    <dbReference type="InParanoid" id="A0A177CWX1"/>
    <dbReference type="OrthoDB" id="3204049at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG12045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="448" mass="51182" checksum="EAEF423D8EC770BF" modified="2016-09-07" version="1">MAHQAHAIPWHTLTSNLVYLHRTPCNQGTTNLYLRKTKDPNQVKQIRHFVRGFARALSAYATIERTKYTPDPTPPDDLDEILISDAAVRKMAKTVLKYKTDDNWSFRGPSENTFTPPPSLPLDSILTPYERSAKSFVWNTMPGEGDMFPELRETCEQTKALLMYGEMDTLFRLAAHADVWFSRMWCEEGWANSHGFGLSKLLDSTLQSYIVLNVISLRPELYDRASRSAYIAKEKAARRTTYAEADYDYRLTAAYQGMLLSCTGVPYGFCSDAHTFPHREFFGVKRGMYRHNYSDTPFERWQKTHLGTQRVEELVCSAFKGVHVPGKGDVAAVINMLGSKGLPVELALQILATAEYEPVGRLPIRDDPFHAANAEELKKYISYCWKLLVRLEMLYKESVHGLTLDWEAEVSHALYRLFNMGGPSLFTNVFPEDHYYFSSVRPRILLAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CX13</accession>
    <name>A0A177CX13_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_1182375</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG11400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041765.1">
        <property type="nucleotide sequence ID" value="XM_018180627.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CX13"/>
    <dbReference type="STRING" id="1460663.A0A177CX13"/>
    <dbReference type="GeneID" id="28764113"/>
    <dbReference type="InParanoid" id="A0A177CX13"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11058">
        <property type="entry name" value="CYP60B-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF210">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE ASQL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 7" id="KW-0349">Heme</keyword>
    <keyword evidence="5 6 7" id="KW-0408">Iron</keyword>
    <keyword evidence="4 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="6">
        <location>
            <position position="355"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAG11400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="409" mass="46916" checksum="DAEB15D8D405F917" modified="2016-09-07" version="1">MDPNSSKSQWASWVLGHLRFAPNELSVIDSAVWKDVYGHRTTNLFTKEKAFYGPDFYGNPPGLIRSDNASHARQRKLVSHAFSDKALREQEQILKGYANLLVEQLTKASQHGEMDLVRFYNYTTFDIMADLTFGEPLGLLQNSKYIPWVAALFGSVRLMTMVGVVKRWPLLDGLLQRYLPRGLKEKRRQHLLFSSERVDKRMQKQTDRPDIWTYVMKEGKGENGEMTGLLPTQLHSNASTFMLAGTETTATELSGITYYLHQHPEKLARLKKEVRDAFTSVDDITMTKLLHLEYLNACIEEGLRIYPPVPAYHSPSNFKDPDSFVPERWLPEGQHEYSADNKEVFNAFSYGPRNCLGKNLAYHEMRLILATVMLSFDMELNKEADDWAQQECHILWAKPAMMAKLTVAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CX59</accession>
    <name>A0A177CX59_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RabGAP/TBC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1253798</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG11309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041674.1">
        <property type="nucleotide sequence ID" value="XM_018184405.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CX59"/>
    <dbReference type="STRING" id="1460663.A0A177CX59"/>
    <dbReference type="GeneID" id="28767891"/>
    <dbReference type="InParanoid" id="A0A177CX59"/>
    <dbReference type="OrthoDB" id="294251at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000055">
        <property type="entry name" value="TBC domain-containing protein C1778.09"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000023">
        <property type="entry name" value="TBC domain-containing protein C1778.09"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF9">
        <property type="entry name" value="GTPASE ACTIVATING PROTEIN AND CENTROSOME-ASSOCIATED, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="2">
        <location>
            <begin position="509"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="244"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="358"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="68"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="210"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="262"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="285"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="371"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="390"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="405"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG11309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="778" mass="85645" checksum="7E53A32096AE8531" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CY09</accession>
    <name>A0A177CY09_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">YVTN repeat-like/Quino protein amine dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1133730</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG11730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042095.1">
        <property type="nucleotide sequence ID" value="XM_018175993.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CY09"/>
    <dbReference type="STRING" id="1460663.A0A177CY09"/>
    <dbReference type="GeneID" id="28759479"/>
    <dbReference type="InParanoid" id="A0A177CY09"/>
    <dbReference type="OrthoDB" id="1367865at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19879">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19879:SF9">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69322">
        <property type="entry name" value="Tricorn protease domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="293"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="563"/>
            <end position="591"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG11730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="591" mass="66059" checksum="FF6C2787AA256A35" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CY64</accession>
    <name>A0A177CY64_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1171225</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042879.1">
        <property type="nucleotide sequence ID" value="XM_018179900.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CY64"/>
    <dbReference type="GeneID" id="28763386"/>
    <dbReference type="InParanoid" id="A0A177CY64"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="13"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG12514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="230" mass="24440" checksum="E9004CCA87F330DB" modified="2016-09-07" version="1">MLAWRSRRGTQGRAALPIAAPSASRRSAASAWPDTLPDATRNTSTHLSARCQLAPRDGLLRSVIPLAQANHASPRRVTSTACEAAPDPASKVIFPAHALARARGLKNTQETPLSSGPGMCGRFRGPDSGLVQYEARDSASWVPQTAPTDRAECVPCGTLAVGSVLLACWQRTPVARFSFTDVIASVPGHADPGRDWRRDSVPACTNYSSLRIVAMVRIVEAACLSFKTGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CY91</accession>
    <name>A0A177CY91_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">GroES-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CC84DRAFT_1159240</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG11797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042162.1">
        <property type="nucleotide sequence ID" value="XM_018177175.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CY91"/>
    <dbReference type="STRING" id="1460663.A0A177CY91"/>
    <dbReference type="GeneID" id="28760661"/>
    <dbReference type="InParanoid" id="A0A177CY91"/>
    <dbReference type="OrthoDB" id="1879366at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05283">
        <property type="entry name" value="CAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000022">
        <property type="entry name" value="Cinnamyl alcohol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.180.10:FF:000022">
        <property type="entry name" value="NADP-dependent alcohol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047109">
        <property type="entry name" value="CAD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42683">
        <property type="entry name" value="ALDEHYDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="6">
        <location>
            <begin position="9"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAG11797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="331" mass="35346" checksum="D2831474CC3D55EB" modified="2016-09-07" version="1">MPSFTVYKGSDSGKIVKAQTTRPDLKNDDVLVKVTASGVCGTDEHYKHADMALGHEGAGVVEDVGPGVTSLKKGDRVGWGYEHDSCGHCEYCLSGREQYCPERKMYGMADTDQGSFASHGVWREAFLFKIPDALTDIEAAPLMCGGATVFNALQATGVKPTDRVGIMGVGGLGHLAIQFASKMGCDVVVLSGTDSKKEEATKLGANDFIATKDKKEIDVGRKIDVLVVTTSVMPDWNVVLPALAPTATIIPLTVSEGDFVIPQNPLILGGHTIQGVAVSARAVHRQMLAFAALHNIKPIVMKFPMTEGGIEEAMGTLRDGKMRYRGVLIPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2023-06-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CYH8</accession>
    <name>A0A177CYH8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_129891</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042970.1">
        <property type="nucleotide sequence ID" value="XM_018185375.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CYH8"/>
    <dbReference type="GeneID" id="28768861"/>
    <dbReference type="InParanoid" id="A0A177CYH8"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG12605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="209" mass="22024" checksum="D45F9CFBD9FE44B5" modified="2016-09-07" version="1">MASRWPKKDLRHGTARSLAHSFATGVLVLERGQSKPVVTDFAFSPAHWSALHPYLTLSPSAADFNTHQPLTLPTHLLGSATGVPNAECGPGDGPGPDVEPLRDESMPHGIGQTYTGRYAQSAQVSLACDDRPMSGAPGPQPSKSAKAAEHTLHPVVKALVCASFRRNGPSKRNHSARRANTSSCGLHFSARNGGAVRGTSSITITAYRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CZ42</accession>
    <name>A0A177CZ42_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CC84DRAFT_1211974</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042776.1">
        <property type="nucleotide sequence ID" value="XM_018182414.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CZ42"/>
    <dbReference type="STRING" id="1460663.A0A177CZ42"/>
    <dbReference type="GeneID" id="28765900"/>
    <dbReference type="InParanoid" id="A0A177CZ42"/>
    <dbReference type="OrthoDB" id="5398233at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF19">
        <property type="entry name" value="MEMBRANE PROTEIN PTH11-LIKE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G14080)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="142"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="190"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="225"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="259"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="42"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="349"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="374"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="415"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="493"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="440"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="494"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="525"/>
            <end position="535"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAG12411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="544" mass="60338" checksum="AEDE2F8D239933AE" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CZY2</accession>
    <name>A0A177CZY2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_1159973</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MAD2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018043066.1">
        <property type="nucleotide sequence ID" value="XM_018177374.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CZY2"/>
    <dbReference type="STRING" id="1460663.A0A177CZY2"/>
    <dbReference type="GeneID" id="28760860"/>
    <dbReference type="InParanoid" id="A0A177CZY2"/>
    <dbReference type="OrthoDB" id="21254at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016035">
        <property type="term" value="C:zeta DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.900.10">
        <property type="entry name" value="HORMA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003511">
        <property type="entry name" value="HORMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036570">
        <property type="entry name" value="HORMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045091">
        <property type="entry name" value="Mad2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11842">
        <property type="entry name" value="MITOTIC SPINDLE ASSEMBLY CHECKPOINT PROTEIN MAD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11842:SF10">
        <property type="entry name" value="MITOTIC SPINDLE ASSEMBLY CHECKPOINT PROTEIN MAD2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02301">
        <property type="entry name" value="HORMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56019">
        <property type="entry name" value="The spindle assembly checkpoint protein mad2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50815">
        <property type="entry name" value="HORMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HORMA" evidence="3">
        <location>
            <begin position="6"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="125"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="202"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="141"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAG12701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="286" mass="31818" checksum="E8073A52D93E7B32" modified="2016-09-07" version="1">MPTTYLTTLAAFTDFLTAYVHTLLYLRHLYPLASFLQVRFHNTPIFQSRHPDVCRWIQDAVAAVREELLKGTIARIAVVVFHPGYDEGSGSVKILERYMLDVSAFPVVTREERFMDIEWEKSEAERRAAEEAATEAETAGHKGKGKGKQKPKGLDAEVDVNLSEQFRAAFITLTTRASQLEPLPPDCSFNISMELKDEADVDPPIGHPQKWVPSQPSLQKTGRKGAVLNDDENHGPSEGGDLGGAKVTPIRTVEAGVFRFETWIEEGKAKFETQWPEMSSIDSSAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177D070</accession>
    <name>A0A177D070_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1160010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018043113.1">
        <property type="nucleotide sequence ID" value="XM_018177380.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177D070"/>
    <dbReference type="GeneID" id="28760866"/>
    <dbReference type="InParanoid" id="A0A177D070"/>
    <dbReference type="OrthoDB" id="10458049at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG12748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="199" mass="23046" checksum="F6C2C872FC4604C9" modified="2016-09-07" version="1">MLDVTRAEITACAFPQTSFEMSCTPKPSPTWHNKLSHIRHRLNRHRPEVVYVGHLYRKVRWCEGSNFTIFYAHNRRVRPCPKVYYIRWRLRGKFFWKVNQPPCNSTKIGQVGTKYPACNRVQKRTSWQTCEMSLDLEQSSGAQSFAICRWIILLPVAMPSAVPWYLLPGSATRLDLEFGSEAVSHWNGSGLFPRQKTSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177D0C4</accession>
    <name>A0A177D0C4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Caffeine-induced death protein-like protein Cid2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1193080</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MIX23 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG13134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018043499.1">
        <property type="nucleotide sequence ID" value="XM_018181272.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177D0C4"/>
    <dbReference type="FunCoup" id="A0A177D0C4">
        <property type="interactions" value="9"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177D0C4"/>
    <dbReference type="GeneID" id="28764758"/>
    <dbReference type="InParanoid" id="A0A177D0C4"/>
    <dbReference type="OrthoDB" id="5593818at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019171">
        <property type="entry name" value="MIX23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016805">
        <property type="entry name" value="MIX23_fungal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31905">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31905:SF2">
        <property type="entry name" value="PROTEIN MIX23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09774">
        <property type="entry name" value="MIX23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF022603">
        <property type="entry name" value="UCP022603"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="181"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00024204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG13134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="194" mass="22016" checksum="114096A7A31686F3" modified="2016-09-07" version="1">MSQPSHLPGLTPQFCFNQTALRDFLRISRSAIDDSISQNLNALLVPGQRSFDPASTSSRSLSAPDRSIPPQTCDTFKQRILFPSWKVRSDVLDYCAGVATAPDPDDPDSVLRQIEDDKMRERVVDERLDPYSARYFPKEARTESLAMLMRNERAVEKIIRSRTWSVVGERCGMESDSAEEAFGKWREGSKQRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2023-06-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177D0P6</accession>
    <name>A0A177D0P6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1171242</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042904.1">
        <property type="nucleotide sequence ID" value="XM_018179901.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177D0P6"/>
    <dbReference type="GeneID" id="28763387"/>
    <dbReference type="InParanoid" id="A0A177D0P6"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG12539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="157" mass="17734" checksum="686190ED8F3063AE" modified="2016-09-07" version="1">MSSPFFLFRKGLLSKPIARWCLSQIPATPQAGMCCLLFGICESKRPRTDFHVVCLRGVYWPLDTHVREEHVWVGASFLKTKKRTRPCCGAETSPESPAPGLSTESSAQLSDLWIRICFPKTDRKHDNGALRSSLRPPGREQKGRLWHEIVLVFASKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177D0V5</accession>
    <name>A0A177D0V5_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mitochondrial import inner membrane translocase subunit TIM54</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CC84DRAFT_162629</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TIM54 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018043232.1">
        <property type="nucleotide sequence ID" value="XM_018185432.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177D0V5"/>
    <dbReference type="FunCoup" id="A0A177D0V5">
        <property type="interactions" value="21"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177D0V5"/>
    <dbReference type="GeneID" id="28768918"/>
    <dbReference type="InParanoid" id="A0A177D0V5"/>
    <dbReference type="OrthoDB" id="5598305at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050187">
        <property type="entry name" value="Lipid_Phosphate_FormReg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021056">
        <property type="entry name" value="Mt_import_IM_translocase_Tim54"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12358:SF101">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12358">
        <property type="entry name" value="SPHINGOSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11711">
        <property type="entry name" value="Tim54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0811">Translocation</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="219"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="10"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OAG12867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="459" mass="52023" checksum="0DF8742C262C58E2" modified="2016-09-07" version="1">MAESDAKASQAPNPSQNAAKPPKPPNPVWRMMGLPNFRWKLPSRNWMIFLSITGSWTAAVVYDRREKKRIQQKWTKMVEHIAKESVNERQMPRKLTIYLSAPPADGLVAARDHFNEYVKPILVAAALDWDAVEGRREGDVRAGLAERIRRLRWKRGETIKDEPELDTKDIVEDLRLRAGVPEWNGPAGDIVIGRHTWKEYIRGMHEGWLGPLDPPASVDLYEPAPPAPEAPPAITSEKVQEQPTPMAPADDASPITVHETPAPSEAEPPKEETKPKKKKQPPPFITTAEYSQAQLPPTCPQALGPSATIALPHLLGFFNFPIRMYRFLNRRKVADDAGREVVSAVLASYRPYDTTASELASSDEYQGAQWEQQRLLTHEEPEWHKTAKERKEGEGERVWLDDMVIDPRIGERMRKFQLSADEEDRANNIPVGKEGASWFTGLWPKREKQPWEGLEDESN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BSV7</accession>
    <name>A0A177BSV7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">chitinase</fullName>
            <ecNumber evidence="3">3.2.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CC84DRAFT_1075110</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 18 family. Chitinase class V subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.14" evidence="3"/>
    <dbReference type="EMBL" id="KV441574">
        <property type="protein sequence ID" value="OAF98482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018028848.1">
        <property type="nucleotide sequence ID" value="XM_018173706.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BSV7"/>
    <dbReference type="STRING" id="1460663.A0A177BSV7"/>
    <dbReference type="GeneID" id="28757192"/>
    <dbReference type="InParanoid" id="A0A177BSV7"/>
    <dbReference type="OrthoDB" id="73875at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050314">
        <property type="entry name" value="Glycosyl_Hydrlase_18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177:SF402">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54556">
        <property type="entry name" value="Chitinase insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="7 9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GH18" evidence="10">
        <location>
            <begin position="43"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OAF98482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="1181" mass="131976" checksum="E276E18C7847C715" modified="2016-09-07" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BTC0</accession>
    <name>A0A177BTC0_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Mediator of RNA polymerase II transcription subunit 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Mediator complex subunit 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CC84DRAFT_1170014</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the Mediator complex subunit 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441565">
        <property type="protein sequence ID" value="OAF98652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029018.1">
        <property type="nucleotide sequence ID" value="XM_018179811.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BTC0"/>
    <dbReference type="STRING" id="1460663.A0A177BTC0"/>
    <dbReference type="GeneID" id="28763297"/>
    <dbReference type="InParanoid" id="A0A177BTC0"/>
    <dbReference type="OrthoDB" id="5310959at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019680">
        <property type="entry name" value="Mediator_Med1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35041">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35041:SF4">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10744">
        <property type="entry name" value="Med1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0010">Activator</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 7" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Mediator complex subunit Med1" evidence="9">
        <location>
            <begin position="81"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="280"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="532"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="532"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF10744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAF98652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="693" mass="75822" checksum="F8D6252CD44B6811" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BTW6</accession>
    <name>A0A177BTW6_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1210692</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441564">
        <property type="protein sequence ID" value="OAF98852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029218.1">
        <property type="nucleotide sequence ID" value="XM_018182306.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BTW6"/>
    <dbReference type="GeneID" id="28765792"/>
    <dbReference type="InParanoid" id="A0A177BTW6"/>
    <dbReference type="OrthoDB" id="3800373at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="151"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="211"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="245"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="365"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="365"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAF98852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="395" mass="44189" checksum="758CA12457DCC76B" modified="2016-09-07" version="1">MHAIEHKREKVDPVPSNERCCICLRDFDDPPDLADNEPPCKPMQLHPCGHLVGDRCHAKLDSHHQGDCLLSTSLVTYTTPVLKMLSIICKMDHLSHVSPVGLLSDAPRFSYSWLYFRRDDFLAIHEHLIANGVSDMQAQLFNRGAYTKREAFSLWFTHLKFLFMYLTTVTLPCPELHDYVLGCLVGGATGIAATVLGYWKNSRILAPHLERAVQPCVLICGMAFELWLTANAKAMHVESGIKASIYFLLTPFVLHAVLYAFVAGWLIHLGWRHRMPTLVWYHRGWEHLGDGESCQFERLAVWASRFGAKLQSPSRTEACHQETGFLSISVPGHSGTKQLAIVPEDVLWTQWPVVVNVEAPTISNAQSIGGPTTVQQRDHACGDELSGDPTSTGNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BV29</accession>
    <name>A0A177BV29_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1200415</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441564">
        <property type="protein sequence ID" value="OAF98830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029196.1">
        <property type="nucleotide sequence ID" value="XM_018181662.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BV29"/>
    <dbReference type="GeneID" id="28765148"/>
    <dbReference type="InParanoid" id="A0A177BV29"/>
    <dbReference type="OrthoDB" id="5372935at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038883">
        <property type="entry name" value="AN11006-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085:SF2">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAF98830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="241" mass="27241" checksum="189516F373D6EEA4" modified="2016-09-07" version="1">MGKGRKASTPFRFFALPSELRIRVLELLLTQTKTVDLDPANSRTLLPALRLFFVSRRMHDEASHVFYATNTFRVFAISGRFFHTKKQLLTRLPQHYIARMRSLELRLGPGFNKPPKGWVVDGRLQLHAATNVRTLKVFVELDPASHPSFEAFRKETCAEAEQFFTVFSAGLLGCLFGELSQLRKVEFDAYPGISRSSPLMRALVEQTRVGGKEVAWGPERGWDKIVDTDLGGMLQKLGIGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BVB9</accession>
    <name>A0A177BVB9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Histone acetyltransferase type B catalytic subunit</fullName>
            <ecNumber evidence="2 7">2.3.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CC84DRAFT_1131312</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalytic component of the histone acetylase B (HAT-B) complex. Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. Involved in DNA double-strand break repair.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-lysyl-[protein] + acetyl-CoA = N(6)-acetyl-L-lysyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:45948"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10731"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="2.3.1.48"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the HAT-B complex composed of at least HAT1 and HAT2. The HAT-B complex binds to histone H4 tail.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the HAT1 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="2 7"/>
    <dbReference type="EMBL" id="KV441562">
        <property type="protein sequence ID" value="OAF99423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029789.1">
        <property type="nucleotide sequence ID" value="XM_018175894.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BVB9"/>
    <dbReference type="FunCoup" id="A0A177BVB9">
        <property type="interactions" value="1134"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177BVB9"/>
    <dbReference type="GeneID" id="28759380"/>
    <dbReference type="InParanoid" id="A0A177BVB9"/>
    <dbReference type="OrthoDB" id="10253098at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004402">
        <property type="term" value="F:histone acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031509">
        <property type="term" value="P:subtelomeric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.360.10">
        <property type="entry name" value="Histone acetyl transferase 1 (HAT1), N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019467">
        <property type="entry name" value="Hat1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037113">
        <property type="entry name" value="Hat1_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017380">
        <property type="entry name" value="Hist_AcTrfase_B-typ_cat-su"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12046">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE TYPE B CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10394">
        <property type="entry name" value="Hat1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038084">
        <property type="entry name" value="HAT-B_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 13" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histone acetyl transferase HAT1 N-terminal" evidence="12">
        <location>
            <begin position="8"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Interaction with histone H4 N-terminus" evidence="9">
        <location>
            <begin position="48"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="474"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="474"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="504"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="8">
        <location>
            <position position="315"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="280"/>
            <end position="282"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <feature type="site" description="Interaction with histone H4 N-terminus" evidence="10">
        <location>
            <position position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR038084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR038084-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR038084-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR038084-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF10394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OAF99423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="526" mass="61072" checksum="20C54CF928F103A6" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BVW2</accession>
    <name>A0A177BVW2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1156600</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441561">
        <property type="protein sequence ID" value="OAF99633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029999.1">
        <property type="nucleotide sequence ID" value="XM_018176979.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BVW2"/>
    <dbReference type="STRING" id="1460663.A0A177BVW2"/>
    <dbReference type="GeneID" id="28760465"/>
    <dbReference type="InParanoid" id="A0A177BVW2"/>
    <dbReference type="OrthoDB" id="66095at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAF99633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="289" mass="32081" checksum="E5F0EF61CAF9CAB8" modified="2016-09-07" version="1">MNRTFQFLSASFSLLWPSGNNQTSTSPARATLQNEGDEPSISYADICVTRAMLKALGLPTELVLEILAHAQYEPVIEFTSRRRVVAEALMGAATSANVCLPAEVLSRNTIRRVSGPNVTLKVKEIKFDIKSKDQGWTSENTTGTFNTSSWLEVSIFRPGPQFSSLEDLPFWTREYDNPQELQEQLSSAGHKLVDERPENASVGAQGGEPPLAWYLQGNKVAERQHSDYQIVWAPDRSEGNQGAGKGDGFFGVLQEGDSVLVWARAKYPGWRCQVDNVKMTVRYSFDEPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BW24</accession>
    <name>A0A177BW24_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_376800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441561">
        <property type="protein sequence ID" value="OAF99693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030059.1">
        <property type="nucleotide sequence ID" value="XM_018185967.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BW24"/>
    <dbReference type="GeneID" id="28769453"/>
    <dbReference type="InParanoid" id="A0A177BW24"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="205"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAF99693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="224" mass="24622" checksum="EFF8C7E8AB49570F" modified="2016-09-07" version="1">MRPPRQQRGHERRPAALCRCPCYVLVLALGLCYSTWHGQRAKQHTDTAVLRVRSSTLPPCCSGEPLFAPPAGPAVSDVVLPRSSAAQDAPTCPLYSAHAQLGENLRRSFQKASPSRNLPSPRRCCPAHRGRPEVPPGCRCARRPRFDCTRPGVDPSRTRQSTGLEPELVNSRHGGTHPSRRDRLVTFKAHSSVHRICEHLCTPAEAGGSSHDAVSKEEARARPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BW29</accession>
    <name>A0A177BW29_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative polyketide synthase PksJ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1238472</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441567">
        <property type="protein sequence ID" value="OAF98539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018028905.1">
        <property type="nucleotide sequence ID" value="XM_018183941.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BW29"/>
    <dbReference type="STRING" id="1460663.A0A177BW29"/>
    <dbReference type="GeneID" id="28767427"/>
    <dbReference type="InParanoid" id="A0A177BW29"/>
    <dbReference type="OrthoDB" id="10253869at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031957">
        <property type="term" value="F:very long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001031">
        <property type="entry name" value="Thioesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096:SF267">
        <property type="entry name" value="MALONATE--COA LIGASE ACSF3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00975">
        <property type="entry name" value="Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="1">
        <location>
            <begin position="532"/>
            <end position="609"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAF98539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="895" mass="99575" checksum="241EA141E1892056" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BWC3</accession>
    <name>A0A177BWC3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial</fullName>
            <ecNumber evidence="20">1.3.5.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">CC84DRAFT_1131865</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23 24">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15 20">Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 20">
            <text>a quinone + succinate = fumarate + a quinol</text>
            <dbReference type="Rhea" id="RHEA:40523"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.3.5.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="18">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="18">Flavinylated by SdhE, about 5% flavinylation occurs in the absence of SdhE.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 20">Carbohydrate metabolism; tricarboxylic acid cycle; fumarate from succinate (eukaryal route): step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 20">Mitochondrion inner membrane</location>
            <topology evidence="1 20">Peripheral membrane protein</topology>
            <orientation evidence="1 20">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 20">Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.3.5.1" evidence="20"/>
    <dbReference type="EMBL" id="KV441563">
        <property type="protein sequence ID" value="OAF99041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029407.1">
        <property type="nucleotide sequence ID" value="XM_018175915.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BWC3"/>
    <dbReference type="FunCoup" id="A0A177BWC3">
        <property type="interactions" value="718"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177BWC3"/>
    <dbReference type="GeneID" id="28759401"/>
    <dbReference type="InParanoid" id="A0A177BWC3"/>
    <dbReference type="OrthoDB" id="71672at2759"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER01006"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045273">
        <property type="term" value="C:respiratory chain complex II (succinate dehydrogenase)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008177">
        <property type="term" value="F:succinate dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006121">
        <property type="term" value="P:mitochondrial electron transport, succinate to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.700.10:FF:000001">
        <property type="entry name" value="Mitochondrial succinate dehydrogenase flavoprotein subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.80.40:FF:000002">
        <property type="entry name" value="Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000482">
        <property type="entry name" value="Succinate dehydrogenase complex, subunit A, flavoprotein (Fp)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:001062">
        <property type="entry name" value="Succinate dehydrogenase complex, subunit A, flavoprotein (Fp)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.100:FF:000001">
        <property type="entry name" value="Succinate dehydrogenase flavoprotein subunit (SdhA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.100">
        <property type="entry name" value="Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.80.40">
        <property type="entry name" value="succinate dehydrogenase protein domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-dep_OxRdtase_2_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003952">
        <property type="entry name" value="FRD_SDH_FAD_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037099">
        <property type="entry name" value="Fum_R/Succ_DH_flav-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015939">
        <property type="entry name" value="Fum_Rdtase/Succ_DH_flav-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030664">
        <property type="entry name" value="SdhA/FrdA/AprA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011281">
        <property type="entry name" value="Succ_DH_flav_su_fwd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014006">
        <property type="entry name" value="Succ_Dhase_FrdA_Gneg"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01816">
        <property type="entry name" value="sdhA_forward"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01812">
        <property type="entry name" value="sdhA_frdA_Gneg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11632">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE 2 FLAVOPROTEIN SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11632:SF51">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE [UBIQUINONE] FLAVOPROTEIN SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02910">
        <property type="entry name" value="Succ_DH_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000171">
        <property type="entry name" value="SDHA_APRA_LASPO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46977">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00504">
        <property type="entry name" value="FRD_SDH_FAD_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 20" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8 18 20" id="KW-0274">FAD</keyword>
    <keyword evidence="6 18 20" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="13 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11 20" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 20" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4 20" id="KW-0813">Transport</keyword>
    <keyword evidence="5 20" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="FAD-dependent oxidoreductase 2 FAD-binding" evidence="21">
        <location>
            <begin position="62"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal" evidence="22">
        <location>
            <begin position="512"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="16">
        <location>
            <position position="339"/>
        </location>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <begin position="67"/>
            <end position="72"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <begin position="90"/>
            <end position="105"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="274"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="295"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="307"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="406"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="440"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="451"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <begin position="456"/>
            <end position="457"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="Tele-8alpha-FAD histidine" evidence="19">
        <location>
            <position position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00059077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR000171-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR611281-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR611281-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR611281-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU362051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF02910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="OAF99041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="647" mass="70977" checksum="191A44A443AA896B" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BWQ8</accession>
    <name>A0A177BWQ8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">FAD/NAD(P)-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_1232840</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAD-binding monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441562">
        <property type="protein sequence ID" value="OAF99390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029756.1">
        <property type="nucleotide sequence ID" value="XM_018183776.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BWQ8"/>
    <dbReference type="GeneID" id="28767262"/>
    <dbReference type="InParanoid" id="A0A177BWQ8"/>
    <dbReference type="OrthoDB" id="66881at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050775">
        <property type="entry name" value="FAD-binding_Monooxygenases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43098:SF2">
        <property type="entry name" value="FAD-BINDING MONOOXYGENASE AUSB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43098">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="7">
        <location>
            <begin position="72"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAF99390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="646" mass="71166" checksum="0E9FABB14AE73DD0" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BYA4</accession>
    <name>A0A177BYA4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Alpha-L-arabinofuranosidase</fullName>
            <ecNumber evidence="11">3.2.1.55</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CC84DRAFT_1199388</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Alpha-L-arabinofuranosidase involved in the hydrolysis of xylan, a major structural heterogeneous polysaccharide found in plant biomass representing the second most abundant polysaccharide in the biosphere, after cellulose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>Hydrolysis of terminal non-reducing alpha-L-arabinofuranoside residues in alpha-L-arabinosides.</text>
            <dbReference type="EC" id="3.2.1.55"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 11">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the glycosyl hydrolase 62 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.55" evidence="11"/>
    <dbReference type="EMBL" id="KV441559">
        <property type="protein sequence ID" value="OAG00494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030859.1">
        <property type="nucleotide sequence ID" value="XM_018181614.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BYA4"/>
    <dbReference type="STRING" id="1460663.A0A177BYA4"/>
    <dbReference type="GeneID" id="28765100"/>
    <dbReference type="InParanoid" id="A0A177BYA4"/>
    <dbReference type="OrthoDB" id="3156236at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046556">
        <property type="term" value="F:alpha-L-arabinofuranosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046373">
        <property type="term" value="P:L-arabinose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd08987">
        <property type="entry name" value="GH62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005193">
        <property type="entry name" value="GH62_arabinosidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40631">
        <property type="entry name" value="ALPHA-L-ARABINOFURANOSIDASE AXHA-2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40631:SF1">
        <property type="entry name" value="ALPHA-L-ARABINOFURANOSIDASE AXHA-2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03664">
        <property type="entry name" value="Glyco_hydro_62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9 11" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 11 12" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0858">Xylan degradation</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008057470" description="Alpha-L-arabinofuranosidase" evidence="12">
        <location>
            <begin position="22"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OAG00494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="329" mass="35144" checksum="0E79770647356B4E" modified="2016-09-07" version="1">MVNFNLSFGLLSLALASTSQASPLTQRACDLPTKYKWTSTGALAQPKNGWVSLKDFTTAPYNGKHLVYATTHDSGSSWGSMAFGLVSNWNDLGSASQTKQNAAAVAPTLFFHQPKNVWVLAYQWGPTAFSYKTSSDPTNPNGWGAAQPLFTGSISGSGTGPIDQTLIADSQNMYLFFAGDNGKIYRSSMPLGNFPGSFGSSSTVVMSDSTNNLFEAVQVYTLTGLNKYLMIVEAIGSNGRYFRSFTATSLGGSWTPNAATESNPFAGKANSGATWTNDISHGELVRTANDQTFPVDPCNLQLLYQGRSPSSGGDYGQLPYRPGVLTMSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BZ69</accession>
    <name>A0A177BZ69_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Small nuclear ribonucleoprotein Sm D1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">snRNP core protein D1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CC84DRAFT_1130684</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in splicing regulation. Facilitates post-transcriptional gene silencing (PTGS) by limiting the degradation of transgene aberrant RNAs by the RNA quality control (RQC) machinery, thus favoring their entry into cytoplasmic siRNA bodies where they can trigger PTGS. Does not participate in the production of small RNAs.</text>
    </comment>
    <comment type="function">
        <text evidence="7">Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the snRNP core protein family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441561">
        <property type="protein sequence ID" value="OAF99736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030102.1">
        <property type="nucleotide sequence ID" value="XM_018175867.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BZ69"/>
    <dbReference type="FunCoup" id="A0A177BZ69">
        <property type="interactions" value="1055"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177BZ69"/>
    <dbReference type="GeneID" id="28759353"/>
    <dbReference type="InParanoid" id="A0A177BZ69"/>
    <dbReference type="OrthoDB" id="9626941at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031981">
        <property type="term" value="C:nuclear lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01724">
        <property type="entry name" value="Sm_D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000008">
        <property type="entry name" value="Small nuclear ribonucleoprotein Sm D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027141">
        <property type="entry name" value="LSm4/Sm_D1/D3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034102">
        <property type="entry name" value="Sm_D1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23338">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="4 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 7" id="KW-0687">Ribonucleoprotein</keyword>
    <feature type="domain" description="Sm" evidence="9">
        <location>
            <begin position="2"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="78"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="100"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="119"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00054531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAF99736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="128" mass="13621" checksum="64E060F285604120" modified="2016-09-07" version="1">MKLVRFLMKCQNETVTVELKNGTIVNGTIASVSPLMNVALRTVKYTPRGRDTVTLDTMTVRGSTVRYIILPDSLPLDTLLIDDAPKPKNKARKETDRGGRGGGGGGRGGPRGRGGRGGGRGRGRGRGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BZP5</accession>
    <name>A0A177BZP5_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tryptophan--tRNA ligase, cytoplasmic</fullName>
            <ecNumber evidence="3">6.1.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Tryptophanyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CC84DRAFT_1168945</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.2" evidence="3"/>
    <dbReference type="EMBL" id="KV441560">
        <property type="protein sequence ID" value="OAG00062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030427.1">
        <property type="nucleotide sequence ID" value="XM_018179532.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BZP5"/>
    <dbReference type="FunCoup" id="A0A177BZP5">
        <property type="interactions" value="1076"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177BZP5"/>
    <dbReference type="GeneID" id="28763018"/>
    <dbReference type="InParanoid" id="A0A177BZP5"/>
    <dbReference type="OrthoDB" id="10261385at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990825">
        <property type="term" value="F:sequence-specific mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004830">
        <property type="term" value="F:tryptophan-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006436">
        <property type="term" value="P:tryptophanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00806">
        <property type="entry name" value="TrpRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.240.10:FF:000003">
        <property type="entry name" value="Tryptophan--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000033">
        <property type="entry name" value="tryptophan--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.240.10">
        <property type="entry name" value="Tyrosyl-Transfer RNA Synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002306">
        <property type="entry name" value="Trp-tRNA-ligase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00233">
        <property type="entry name" value="trpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10055:SF1">
        <property type="entry name" value="TRYPTOPHAN--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10055">
        <property type="entry name" value="TRYPTOPHANYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01039">
        <property type="entry name" value="TRNASYNTHTRP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12 14" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="8 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="7 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 12" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="443"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="473"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OAG00062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="493" mass="55843" checksum="C8A61E0A847F097E" modified="2016-09-07" version="1">MTEPEPPSVAALSLAETATEPVHGKKKEQEINPWDVQAATDEQGNVLEFDYPAISQKWATKLIDDEILARFERVTGHKPHRWLRRRLFFSHRDLELILDTYERDGEFLLYTGRGPSSDSMHIGHTIPFEFTKWLQDVFDVPLVIMLTDDEKFLFKEKLTQPEVYEFARGNAKDIISIGFDPKKTFIYIDSEFFTSGYNRHFSLNATEFEKLITNNQVRGAFGFHGSTNIGSNAFAAKQCVAAFASSYPFIWGNDIKTYHRSAKLAAMPCLIPCAIDQDPYFRLVRDNCSRMAQPSPKPALIHSKFLTALQGAGGKMSASNPNSAIFMSDTENQVKKKINSHAFSGGQETEALHREKGGNPDIDVPYQYLAYFEDDDEKLLKLADGYRKGEILTGEMKKECITLMQKYVKGFQEARSKVTDEVLAEFLRPRKLEWTGNPRVEKKEVKEEAVEGGAQLGEDGKPMTKNQLKKLLKAQETERKKKEKEAAKAAAQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2023-06-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C031</accession>
    <name>A0A177C031_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1168003</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441558">
        <property type="protein sequence ID" value="OAG00766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031131.1">
        <property type="nucleotide sequence ID" value="XM_018179302.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C031"/>
    <dbReference type="GeneID" id="28762788"/>
    <dbReference type="InParanoid" id="A0A177C031"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG00766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="129" mass="14304" checksum="84BD177E24CAF473" modified="2016-09-07" version="1">MVRCENPIHGTGSSSACGLIVSHSVPPGRTLRSNSAPRPHRPGRMHAPLSTPRLPLHEPLLSHLHFQREPSKLTAVITIHAVIRLRDNTHTLSLPFSRSKGQSQYHVDFISNPCQHENFNPAVHTISSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C0D5</accession>
    <name>A0A177C0D5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">FAD-linked oxidase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CC84DRAFT_1230114</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KV441559">
        <property type="protein sequence ID" value="OAG00268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030633.1">
        <property type="nucleotide sequence ID" value="XM_018183689.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C0D5"/>
    <dbReference type="STRING" id="1460663.A0A177C0D5"/>
    <dbReference type="GeneID" id="28767175"/>
    <dbReference type="InParanoid" id="A0A177C0D5"/>
    <dbReference type="OrthoDB" id="5332616at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004458">
        <property type="term" value="F:D-lactate dehydrogenase (cytochrome) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008720">
        <property type="term" value="F:D-lactate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903457">
        <property type="term" value="P:lactate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.10">
        <property type="entry name" value="FAD-linked oxidases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="entry name" value="Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.45.10">
        <property type="entry name" value="Vanillyl-alcohol Oxidase, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016170">
        <property type="entry name" value="Cytok_DH_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004113">
        <property type="entry name" value="FAD-bd_oxidored_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016164">
        <property type="entry name" value="FAD-linked_Oxase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016171">
        <property type="entry name" value="Vanillyl_alc_oxidase_C-sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11748:SF114">
        <property type="entry name" value="ARYL-ALCOHOL OXIDASE VANILLYL-ALCOHOL OXIDASE (AFU_ORTHOLOGUE AFUA_3G09500)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11748">
        <property type="entry name" value="D-LACTATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02913">
        <property type="entry name" value="FAD-oxidase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55103">
        <property type="entry name" value="FAD-linked oxidases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="5">
        <location>
            <begin position="80"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAG00268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="571" mass="63775" checksum="020DE9C3D97E0367" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C0H4</accession>
    <name>A0A177C0H4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CC84DRAFT_324803</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441559">
        <property type="protein sequence ID" value="OAG00731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031096.1">
        <property type="nucleotide sequence ID" value="XM_018185854.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C0H4"/>
    <dbReference type="STRING" id="1460663.A0A177C0H4"/>
    <dbReference type="GeneID" id="28769340"/>
    <dbReference type="InParanoid" id="A0A177C0H4"/>
    <dbReference type="OrthoDB" id="8117402at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001666">
        <property type="entry name" value="MDS1 and EVI1 complex locus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001732">
        <property type="entry name" value="Zgc:162936"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050331">
        <property type="entry name" value="Zinc_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515:SF49">
        <property type="entry name" value="GASTRULA ZINC FINGER PROTEIN XLCGF49.1-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515">
        <property type="entry name" value="PR DOMAIN ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="229"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="257"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="285"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="122"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="302"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="124"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="155"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="210"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="325"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="348"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="361"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="417"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="462"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="493"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="524"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAG00731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="607" mass="65202" checksum="8EE9E109DD02AFA8" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C0S1</accession>
    <name>A0A177C0S1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ribosome biogenesis protein SLX9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CC84DRAFT_1179929</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLX9 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441558">
        <property type="protein sequence ID" value="OAG00811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031176.1">
        <property type="nucleotide sequence ID" value="XM_018180445.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C0S1"/>
    <dbReference type="GeneID" id="28763931"/>
    <dbReference type="InParanoid" id="A0A177C0S1"/>
    <dbReference type="OrthoDB" id="5429132at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028160">
        <property type="entry name" value="Slx9-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15341">
        <property type="entry name" value="SLX9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAG00811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="173" mass="18941" checksum="FC8810C90B3657C0" modified="2016-09-07" version="1">MAPISGKKRTSARAKSSRAARPQATLPTPADDALFSSSKKDKRTIKHSAFVSKIERSSSKIQKRRRPNKKLVTNLESLADALSGLEQGDGNGELVVGQAKIQRKSLKSRPGAMKKKEKLEKLEKERFNMNLAQMATTSTASSATGSNPAADRWAALKKHVKNTAEIKPEFLQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C0Y1</accession>
    <name>A0A177C0Y1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1180544</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441559">
        <property type="protein sequence ID" value="OAG00539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030904.1">
        <property type="nucleotide sequence ID" value="XM_018180482.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C0Y1"/>
    <dbReference type="GeneID" id="28763968"/>
    <dbReference type="InParanoid" id="A0A177C0Y1"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="40"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG00539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="102" mass="11343" checksum="FF750B9B6F12D386" modified="2016-09-07" version="1">MNAEFHATRPVSLFTNKMSSTTNHTSSETAPPPYSPSDTASLASTSSKSALLKQLLHKKPSEGSTPKQAKNKSKKEQRPQQEHQHYDRETFWAAAAVWASMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C1B9</accession>
    <name>A0A177C1B9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Bet v1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1167774</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441557">
        <property type="protein sequence ID" value="OAG01584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031949.1">
        <property type="nucleotide sequence ID" value="XM_018179260.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C1B9"/>
    <dbReference type="GeneID" id="28762746"/>
    <dbReference type="InParanoid" id="A0A177C1B9"/>
    <dbReference type="OrthoDB" id="10255646at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019587">
        <property type="entry name" value="Polyketide_cyclase/dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39332">
        <property type="entry name" value="BLL4707 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39332:SF7">
        <property type="entry name" value="SRPBCC FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10604">
        <property type="entry name" value="Polyketide_cyc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG01584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="152" mass="16781" checksum="5AE87FAFE0F3941E" modified="2016-09-07" version="1">MSDSRIPTSTSVSESAVIEAPFSAVWHLIKLQDFSKFWSKLEKSEVVKSSSPETDVIKWTFKDGTELDVKQEEHSSIDHFITYSVISSQPALSYTSVVSTIRAYPVTSGKHEGQTFITWTGNFSSDADAGVIEDAKFKRREALADLAKAAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C1L8</accession>
    <name>A0A177C1L8_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF202 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1221160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441557">
        <property type="protein sequence ID" value="OAG01674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032039.1">
        <property type="nucleotide sequence ID" value="XM_018183236.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C1L8"/>
    <dbReference type="GeneID" id="28766722"/>
    <dbReference type="InParanoid" id="A0A177C1L8"/>
    <dbReference type="OrthoDB" id="2555434at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38646:SF1">
        <property type="entry name" value="DUF202 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38646">
        <property type="entry name" value="YALI0F00814P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG01674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="137" mass="15395" checksum="B6712E040A184550" modified="2016-09-07" version="1">MFEGRHTADRYNLRLHRARSVVLSGPELVEIRAAQRTFEGAYIRTALGQFSFALIVLKIFTAEFYSIGALFAVYGAGILFTSLFRRQQGNKQFFSEVGEDGLQRKKFRTSGNVVSVLTALSMAAYICLMVLTLRLDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C1S1</accession>
    <name>A0A177C1S1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1179944</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441558">
        <property type="protein sequence ID" value="OAG00829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031194.1">
        <property type="nucleotide sequence ID" value="XM_018180447.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C1S1"/>
    <dbReference type="STRING" id="1460663.A0A177C1S1"/>
    <dbReference type="GeneID" id="28763933"/>
    <dbReference type="InParanoid" id="A0A177C1S1"/>
    <dbReference type="OrthoDB" id="5422579at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG00829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="477" mass="54228" checksum="9E81F2BA371F5BB7" modified="2016-09-07" version="1">MSTPHLPVEIHDIICSHLARGDLHSYRSASRYLANIGAQYLFRHLTFHASYASLDRIANVGNYNHLTCLVETVTWDTSSINLDVTDFDDWKTKILSLRCQELGELRSRWYKQIQNHDACENLVQRYFWEEYERYKAMVATERDVQALLLRNVANLVALFPKLKTILVEKKRYDYDDGYLDMEVLEPHSEKLVKRGMLHRHPLSRPVPYKHSTDMFPLVAALNAAQKSTQQVEARTLRYKIFSQLEYTQHLQHVDVSQITRLNLRFALLDPSSNPQDSSLNIMNCRHTLSQGHLREFLQKFSNLQSLGLDFEARSLGNGRAPANLQDIFLVVQDVVWPCLQHLTIYHADTPASNFTALLASHASSLRSLSLSDVCLDPPGSWEAILTDLQPHLSLSSATFSQFLFDARIDSFLRGRSALMGWYCDSEESVEAMSSLGPRLEKFMVKGGACPLNEEKKVARIVGRMEDLVGGGSASVII</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C1U2</accession>
    <name>A0A177C1U2_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">FAD/NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CC84DRAFT_1167912</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FMO family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441557">
        <property type="protein sequence ID" value="OAG01754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032119.1">
        <property type="nucleotide sequence ID" value="XM_018179284.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C1U2"/>
    <dbReference type="GeneID" id="28762770"/>
    <dbReference type="InParanoid" id="A0A177C1U2"/>
    <dbReference type="OrthoDB" id="66881at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000960">
        <property type="entry name" value="Flavin_mOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050346">
        <property type="entry name" value="FMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23023">
        <property type="entry name" value="DIMETHYLANILINE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00370">
        <property type="entry name" value="FMOXYGENASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAG01754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="735" mass="81689" checksum="D4F2317B64D9B04B" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C2A9</accession>
    <name>A0A177C2A9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CC84DRAFT_218426</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="KV441557">
        <property type="protein sequence ID" value="OAG01783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032148.1">
        <property type="nucleotide sequence ID" value="XM_018185621.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C2A9"/>
    <dbReference type="STRING" id="1460663.A0A177C2A9"/>
    <dbReference type="GeneID" id="28769107"/>
    <dbReference type="InParanoid" id="A0A177C2A9"/>
    <dbReference type="OrthoDB" id="310217at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050660">
        <property type="entry name" value="NEK_Ser/Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43671">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE NEK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43671:SF98">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE NEK11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="1"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="254"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="254"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OAG01783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="353" mass="39835" checksum="5D487BC43933DF6B" modified="2016-09-07" version="1">MIKDGTILQEITILKYLSSPSHENITKLVDHFVDKKLCKVSIYLKECSMGRLEALIESRYQGGELFNELDVWEWFIQLFSALTYCHYGPDPTARFAYNRPEDWENEWDRVFHWDIKVENILAHEATPKGMTTQYTLKLADFGCAVARRYIWVDTANDRKKTSWCTRRWTPPEYPQFVGRSDVWQLAAVVGCICNLMNVPFFDHAAPAPGYSVTLNNAIVESMKKDFRQRPKADEVLGHVRGKYKVKAEVLEKDPRPVPDKLDKVKKDRRERQLKRGLEKGSKEQQQQAAAAQALNRQAQVVGQWGVGNDGFGGPGPFAGAGWGGLGGRGGGPGNMQPFGRIGRGWYGSGGGMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C2X7</accession>
    <name>A0A177C2X7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_200703</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441557">
        <property type="protein sequence ID" value="OAG01521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031886.1">
        <property type="nucleotide sequence ID" value="XM_018185564.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C2X7"/>
    <dbReference type="GeneID" id="28769050"/>
    <dbReference type="InParanoid" id="A0A177C2X7"/>
    <dbReference type="OrthoDB" id="5979581at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG01521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="369" mass="41690" checksum="B244EC404DD95233" modified="2016-09-07" version="1">MYDKDTSAAWLCLPRNLDTTPGFEDEEAQEEPPAHLFRPDSSADIPRHDANVGEKLHRKARAQLVVVRMYKSLDALRNEMETLNMMHDFKRSGDFIGPLGLRACYSIPTASWLCLRPIFGKSLEAFGQACLDTNRIPTYFVWHIFIRLLSAVEFVHAAGIAHGDLSSANVMLRCSLPDSPEREWPDVVLTGFEVEVDMDLYEDERREDVKRMAGILYTDVISQWSDSAMLMSFIDLTFPQADPLMQFAAELKALVDARLDQYVDLEDFDEWKSVAISERARGPGYCPAWIKTAAYDVLVTEKELGKAMGPPLVLRFGPGSEKFKRWVRARRTPVALPRTPTRGPARFGLLVIKFKIRKGEFANLAGTGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C317</accession>
    <name>A0A177C317_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">threonine--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Threonyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CC84DRAFT_1168312</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>tRNA(Thr) + L-threonine + ATP = L-threonyl-tRNA(Thr) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24624"/>
            <dbReference type="Rhea" id="RHEA-COMP:9670"/>
            <dbReference type="Rhea" id="RHEA-COMP:9704"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78534"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.3" evidence="3"/>
    <dbReference type="EMBL" id="KV441558">
        <property type="protein sequence ID" value="OAG01178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031543.1">
        <property type="nucleotide sequence ID" value="XM_018179365.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C317"/>
    <dbReference type="FunCoup" id="A0A177C317">
        <property type="interactions" value="69"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177C317"/>
    <dbReference type="GeneID" id="28762851"/>
    <dbReference type="InParanoid" id="A0A177C317"/>
    <dbReference type="OrthoDB" id="5423599at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004829">
        <property type="term" value="F:threonine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070159">
        <property type="term" value="P:mitochondrial threonyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00771">
        <property type="entry name" value="ThrRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000039">
        <property type="entry name" value="Threonyl-tRNA synthetase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002320">
        <property type="entry name" value="Thr-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033728">
        <property type="entry name" value="ThrRS_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11451:SF50">
        <property type="entry name" value="THREONINE--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11451">
        <property type="entry name" value="THREONINE-TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01047">
        <property type="entry name" value="TRNASYNTHTHR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="13">
        <location>
            <begin position="15"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OAG01178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="463" mass="52280" checksum="98F6BA9683F4D2FC" modified="2016-09-07" version="1">MSPGSPLLLPNGAYVFQKLQDFLRAQYPQFGYKEVITPTIYKKSLWEKSGHWDNYAEDMFSVQGRGATGQTENAQAGEDEEFGLKPMNCPGHCLLFWGEGELKSYRDLPVRYADFSALHRNEISGSLTGLTRVRRFHQDDAHIFCRPDQILSEIEQTLKFVGMVYDTFNLGPYKLLLSTRPEEHYIGTLEEWNRAEEQLTTALNNSGREWAINEGDGAFYGPKIDIILKDATGKEHQTATIQLDFQLPQRFDLQYQASPEELEAGAVSAGDKNIDPSCRRPVIVHRAIYGSLERFMALLIEHYNGSFPFWLSPRPAVVVTLNQKPELLEYAARVQSVLAGVLDPSHSNNAQTSADFKPTPRQLSAIHLPIDVDSSARQLGKKLREAHNKKYNHIIVIGAEEAKSQTVRLNIKNQPNDGAVREVITEVLGRPLTEEDELKGTISVGMTIEEARRYFLALVERFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C371</accession>
    <name>A0A177C371_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">T6SS Phospholipase effector Tle1-like catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1100482</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441557">
        <property type="protein sequence ID" value="OAG01359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031724.1">
        <property type="nucleotide sequence ID" value="XM_018174869.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C371"/>
    <dbReference type="STRING" id="1460663.A0A177C371"/>
    <dbReference type="GeneID" id="28758355"/>
    <dbReference type="InParanoid" id="A0A177C371"/>
    <dbReference type="OrthoDB" id="3057168at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018712">
        <property type="entry name" value="Tle1-like_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33840:SF16">
        <property type="entry name" value="DUF2235 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09994">
        <property type="entry name" value="T6SS_Tle1-like_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T6SS Phospholipase effector Tle1-like catalytic" evidence="1">
        <location>
            <begin position="18"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG01359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="259" mass="28780" checksum="E93F88258025519C" modified="2016-09-07" version="1">MPASATREKRPAPPQPKKRIIICCDGTWQSSAHGTQTIPSNVAKMSRSIASWYVDENGLKAPQLVYYDAGVGTAMGWLEAKWTGAFGGGLDENVCEAYNFLVNNYSPGDELFFFGFSRGAYTVRACAGLVCRAGICKPRAMGQFWEMYAMYKSIDPSTALEKSAWGERWEAEGSPPKFTIKVKGEDWEFTKGAGADWLDSSEKNVKIKVVGVWDTVGSLGYPDNVWVETKEKNKPYGFHNTDIHSRRWIIPASYVKTDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2023-06-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C3C5</accession>
    <name>A0A177C3C5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_194195</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441557">
        <property type="protein sequence ID" value="OAG01409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031774.1">
        <property type="nucleotide sequence ID" value="XM_018185543.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C3C5"/>
    <dbReference type="GeneID" id="28769029"/>
    <dbReference type="InParanoid" id="A0A177C3C5"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG01409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="259" mass="29047" checksum="C74573198404B80A" modified="2016-09-07" version="1">MVPSHPECVLELINTARGGSTDRTFPAPEHCPPHDGGQVFLYCIMMLSNIATQYVSAAPDEVCYIFRTQGTLGDSYSLRFCIALLETRSLNFPSIGCCVGGLKTHLSNQIMGCALGKTKNAFGVYHEICVVENWNSCMTTLLMLSWGVMTFYNSEYYVITALDENDLVRCPRWRRLVLYTLETFSWELKVDLRLCDVLACQSVSKREPSTYTRVLLRRLKTLIGSLNGGARRRTGLISGLCPSPVKKFCAAGLWSTRWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C4N0</accession>
    <name>A0A177C4N0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DHH phosphoesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1167972</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441557">
        <property type="protein sequence ID" value="OAG01832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032197.1">
        <property type="nucleotide sequence ID" value="XM_018179295.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C4N0"/>
    <dbReference type="STRING" id="1460663.A0A177C4N0"/>
    <dbReference type="GeneID" id="28762781"/>
    <dbReference type="InParanoid" id="A0A177C4N0"/>
    <dbReference type="OrthoDB" id="284473at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1640.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001667">
        <property type="entry name" value="DDH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038763">
        <property type="entry name" value="DHH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051673">
        <property type="entry name" value="SSDNA_exonuclease_RecJ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30255">
        <property type="entry name" value="SINGLE-STRANDED-DNA-SPECIFIC EXONUCLEASE RECJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30255:SF2">
        <property type="entry name" value="SINGLE-STRANDED-DNA-SPECIFIC EXONUCLEASE RECJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01368">
        <property type="entry name" value="DHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64182">
        <property type="entry name" value="DHH phosphoesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDH" evidence="2">
        <location>
            <begin position="108"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="453"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="455"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG01832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="484" mass="53488" checksum="56AC2A98C75B0AD4" modified="2016-09-07" version="1">MSLVSRVLPRLSRGLNHTAYRPITSFLLVSTPHTFHTTYMMSSPAKRKAETQASPAKAKKPKVQIPEYHLTPSRRDEDGEIVWPAPKAQIERAREIIRECASAQKPTLILPDKDADGLSSGAILHHTLTSLGLSSDLISVYFPPKGSNVHDESTRSTVTELSPAYIFVLDQGSRKTGPFYDASHKCLIIDHHFAEEGGFPEGAEFVTAHDCPPVATSALLTYAICLPLHQDLEDKISWLAALGTHGDLGNTLKWQPPFPDMTATFKRNPKKAINDAVGLVNAPRRSAAYNVQAAWEAVISVEGPQPLLSNEKLRDAQFEVKQETEKWSHVPPKFSRDATIAILTIRSAAQVHPVVATRWAGFLKSDKLEIVMCANEGYLPGKVNFSCRVAKHARARIGDDRVNIIQTLESIVADDPDLRARLGESFARGHKEASGGIINVQEWEEFKKLMGVGENSRKKAETKTPEKKKPAQKNTLQNYFVKAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C4V1</accession>
    <name>A0A177C4V1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1167915</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441557">
        <property type="protein sequence ID" value="OAG01757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032122.1">
        <property type="nucleotide sequence ID" value="XM_018179285.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C4V1"/>
    <dbReference type="STRING" id="1460663.A0A177C4V1"/>
    <dbReference type="GeneID" id="28762771"/>
    <dbReference type="InParanoid" id="A0A177C4V1"/>
    <dbReference type="OrthoDB" id="10262413at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051783">
        <property type="entry name" value="NAD(P)-dependent_oxidoreduct"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48079:SF6">
        <property type="entry name" value="NAD(P)-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48079">
        <property type="entry name" value="PROTEIN YEEZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="1">
        <location>
            <begin position="5"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG01757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="362" mass="38827" checksum="15E252C97B2B2310" modified="2016-09-07" version="1">MSRNILITGASGYLGGTFLKLLKDAGLPAHKIYAVVRSDKQAEAVEQYNASPLSLDVSNTDAVSTAIIDNNISIIYHLHNPLDTSTPAWIKALATVKQHTGQDVHFLLTTGAKLFSSHAGAPTDPFSDTDPSLLSIQQSQPGKAPIDAMGLGAHCNNLVIATAKAHGVKSYIFAPCIVYGRGLGFGNKISIQTVAVVKAAVATRRVYKVDEGRPTWPVCHVEDNSTLYIEILRGILEGRDIGSGENGYFLASPGSVAWDDIYAAMGKALKKRGVVDDETVVKADKTALEKMGEGMDCPADFVPMQLGGLCTWVPKHGKKIGWKPKYAAEHILEAADAEVELILEHLENARSYAIPKGTPLKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C580</accession>
    <name>A0A177C580_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1252994</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441556">
        <property type="protein sequence ID" value="OAG02311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032676.1">
        <property type="nucleotide sequence ID" value="XM_018184381.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C580"/>
    <dbReference type="GeneID" id="28767867"/>
    <dbReference type="InParanoid" id="A0A177C580"/>
    <dbReference type="OrthoDB" id="755951at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG02311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="205" mass="23329" checksum="606A7B3610441E42" modified="2016-09-07" version="1">MTVNYAPPFHPGVAPAAQISLRVSKYWTDNPTALREMHGFELVRRLCNGSISILVAVSHSPPSTVLSWNRSVRAEQSCKNRWFILNHEGSLANYGSINETVITKFDDFIDILSDKKNDKKNAVYVMSGRTVLWLNTLSAFPVNLADRKADPCTAQDLTWKWRLYAKYTLEIFCDYYDRQSGYSPRSMAFHSQALSSQSPEPRRTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2023-06-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C5L8</accession>
    <name>A0A177C5L8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1178480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG02913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033278.1">
        <property type="nucleotide sequence ID" value="XM_018180348.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C5L8"/>
    <dbReference type="GeneID" id="28763834"/>
    <dbReference type="InParanoid" id="A0A177C5L8"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG02913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="244" mass="27054" checksum="8DBBF4462C54F23D" modified="2016-09-07" version="1">MAALWCTARPTAHRAHRRSRSLALTLATHTAVKGPRKARTRPPASAGGPVPSTASPLSSDCGLTQRNGCGYTASYRYRENCARRAPVADRSHEARRENRALTPVPFHHAQCITVTPRSDKVTAWKNSREHLPFLRQSGSGTTADWCPGHRPPVVVDALPFPVHVPGITLHTARLTRQHRNPGPSRSWFLAQFPRDHRPWLLARRPSIAHQPWTPPALNAVAAFEKRPTPAENKVWNSLRQHGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C5Y7</accession>
    <name>A0A177C5Y7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1189559</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441556">
        <property type="protein sequence ID" value="OAG02292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032657.1">
        <property type="nucleotide sequence ID" value="XM_018181065.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C5Y7"/>
    <dbReference type="STRING" id="1460663.A0A177C5Y7"/>
    <dbReference type="GeneID" id="28764551"/>
    <dbReference type="InParanoid" id="A0A177C5Y7"/>
    <dbReference type="OrthoDB" id="9988102at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="869"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="897"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="374"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="516"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="633"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="397"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="407"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="424"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="444"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="523"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="639"/>
            <end position="655"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG02292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="921" mass="100905" checksum="F2835EE1B542AF54" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C647</accession>
    <name>A0A177C647_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">PFU-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CC84DRAFT_1167326</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441556">
        <property type="protein sequence ID" value="OAG02207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032572.1">
        <property type="nucleotide sequence ID" value="XM_018179154.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C647"/>
    <dbReference type="FunCoup" id="A0A177C647">
        <property type="interactions" value="1383"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177C647"/>
    <dbReference type="GeneID" id="28762640"/>
    <dbReference type="InParanoid" id="A0A177C647"/>
    <dbReference type="OrthoDB" id="10265988at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010992">
        <property type="term" value="P:ubiquitin recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000236">
        <property type="entry name" value="Polyubiquitin binding protein (Doa1/Ufd3)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.870">
        <property type="entry name" value="PFU (PLAA family ubiquitin binding), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015155">
        <property type="entry name" value="PFU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038122">
        <property type="entry name" value="PFU_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013535">
        <property type="entry name" value="PUL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19849">
        <property type="entry name" value="PHOSPHOLIPASE A-2-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19849:SF0">
        <property type="entry name" value="PHOSPHOLIPASE A-2-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09070">
        <property type="entry name" value="PFU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08324">
        <property type="entry name" value="PUL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51394">
        <property type="entry name" value="PFU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51396">
        <property type="entry name" value="PUL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="10"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="105"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="232"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="PFU" evidence="7">
        <location>
            <begin position="371"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="domain" description="PUL" evidence="8">
        <location>
            <begin position="499"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="461"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAG02207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="767" mass="83452" checksum="56CD5F8B6927930E" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C682</accession>
    <name>A0A177C682_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CC84DRAFT_1126660</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 3-hydroxyacyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441556">
        <property type="protein sequence ID" value="OAG02389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032754.1">
        <property type="nucleotide sequence ID" value="XM_018175750.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C682"/>
    <dbReference type="STRING" id="1460663.A0A177C682"/>
    <dbReference type="GeneID" id="28759236"/>
    <dbReference type="InParanoid" id="A0A177C682"/>
    <dbReference type="OrthoDB" id="5958943at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022694">
        <property type="entry name" value="3-OHacyl-CoA_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006176">
        <property type="entry name" value="3-OHacyl-CoA_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006108">
        <property type="entry name" value="3HC_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48075">
        <property type="entry name" value="3-HYDROXYACYL-COA DEHYDROGENASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48075:SF10">
        <property type="entry name" value="DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G10070)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00725">
        <property type="entry name" value="3HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02737">
        <property type="entry name" value="3HCDH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000105">
        <property type="entry name" value="HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3-hydroxyacyl-CoA dehydrogenase NAD binding" evidence="5">
        <location>
            <begin position="14"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="3-hydroxyacyl-CoA dehydrogenase C-terminal" evidence="4">
        <location>
            <begin position="192"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="3">
        <location>
            <position position="146"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000105-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAG02389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="291" mass="31726" checksum="EF1ED9A92D954B4E" modified="2016-09-07" version="1" fragment="single">MSWQPPSDYATRPVTILGAGVLGRRIACTWAAAGYNVHIRDPSAAQLTQCASYFESNIGTYKQKTSSSTTGTISTFADLEPAVATAWLIVEAVPEVLDLKTKTFTALEAHAPRDALLATNSSSYKSSEMLSGLVSPTTASRILNTHYYMPPANMVVELMTCGHTHAPIFPFLAARLRETGAAPYTARVESTGFIFNRLWAAVKRETLAILSEGVSTPEEIDALWTDMFVRGQATPCRLMDQVGLDTVAFIEAHYVAERGLDDEHTVRYLEREFIAKGRLGDKSGKGGLYPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C6C1</accession>
    <name>A0A177C6C1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1055377</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441556">
        <property type="protein sequence ID" value="OAG02422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032787.1">
        <property type="nucleotide sequence ID" value="XM_018173535.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C6C1"/>
    <dbReference type="GeneID" id="28757021"/>
    <dbReference type="InParanoid" id="A0A177C6C1"/>
    <dbReference type="OrthoDB" id="5278984at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="2">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG02422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="55" mass="6017" checksum="00480478F7EB290E" modified="2016-09-07" version="1" fragment="single">LVLYLPLSPDIIFRRVVYGVISVVIAYTLAYKLIIIFQCTPVAAACDISVKGTCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C6I5</accession>
    <name>A0A177C6I5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1220651</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441556">
        <property type="protein sequence ID" value="OAG02310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032675.1">
        <property type="nucleotide sequence ID" value="XM_018183186.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C6I5"/>
    <dbReference type="GeneID" id="28766672"/>
    <dbReference type="InParanoid" id="A0A177C6I5"/>
    <dbReference type="OrthoDB" id="3784926at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="37"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="134"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="219"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="512"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="552"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="585"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="614"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="356"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG02310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="637" mass="73758" checksum="4C40958567B885E9" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C7H7</accession>
    <name>A0A177C7H7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1165893</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG03704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034069.1">
        <property type="nucleotide sequence ID" value="XM_018178820.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C7H7"/>
    <dbReference type="GeneID" id="28762306"/>
    <dbReference type="InParanoid" id="A0A177C7H7"/>
    <dbReference type="OrthoDB" id="10601037at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008057830" evidence="2">
        <location>
            <begin position="18"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="57"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG03704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="124" mass="12193" checksum="8F391D1D3F7294D2" modified="2016-09-07" version="1">MRPAAAFTIMFAATTLATPAPKPLADPSLEVLTDAPSFAPEVDARAAAFLEARDPKSGSSSSSSSSSGGKSSSGSKSSSGSKTGSKIGKSGNKSGNDSDSAAAMLTSNVVLELGALGLGVLLWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C7L9</accession>
    <name>A0A177C7L9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1261447</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG02747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033112.1">
        <property type="nucleotide sequence ID" value="XM_018185069.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C7L9"/>
    <dbReference type="STRING" id="1460663.A0A177C7L9"/>
    <dbReference type="GeneID" id="28768555"/>
    <dbReference type="InParanoid" id="A0A177C7L9"/>
    <dbReference type="OrthoDB" id="184880at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG02747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="292" mass="32090" checksum="40CD5A681836FBCD" modified="2016-09-07" version="1">MASPVYSSPEWYLKAQDKDVSSDIGRLTIYHLGFKQAAGGTLLFAPLEFSSAPRAVLDVGTADGLWMREVQSTIPAPPEGDHTFIGTDINTSFFPSTSMKNITYVKQDIKDPTPEVWNHAFDLVNLRMILIAAGSGVAQRAVVNEHIKLVKPGGWIQIGDCDRVCPTSEAENPRYHDMFACIRAVCQSSGLDPLEAPKMKSWLEEAGLEQVQERTAMRAVGKRNADEELGKLGIGADLMIAKGFAAGAKGLSPSFKPLPDERLDSLVQELETELTETGAYFPMRFIWARKPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C7Y8</accession>
    <name>A0A177C7Y8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ubiquitin-conjugating enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1151047</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG02888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033253.1">
        <property type="nucleotide sequence ID" value="XM_018176725.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C7Y8"/>
    <dbReference type="STRING" id="1460663.A0A177C7Y8"/>
    <dbReference type="GeneID" id="28760211"/>
    <dbReference type="InParanoid" id="A0A177C7Y8"/>
    <dbReference type="OrthoDB" id="9973183at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23812">
        <property type="entry name" value="UBCc_ScPEX4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000098">
        <property type="entry name" value="Ubiquitin conjugating enzyme (UbcJ)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="2">
        <location>
            <begin position="9"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG02888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="166" mass="18791" checksum="40A5DD061D11120B" modified="2016-09-07" version="1">MASSSRVQSPTKRLLTELQSYQSDPNDALLELGPIDDDELMHWRAVMKGVPGTAYEGGRWALDIHIPNTYPLAPPTIRFITPICHPNVDFKTGEICLDLLKTSWTPAYTITTTMTSIHQLLTSAEPDSPLNVDIAQLFRQEDYVGAEALIRFYTETERWEGGRRRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C8E3</accession>
    <name>A0A177C8E3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Apses-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CC84DRAFT_1248333</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EFG1/PHD1/stuA family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG03401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033766.1">
        <property type="nucleotide sequence ID" value="XM_018184261.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C8E3"/>
    <dbReference type="STRING" id="1460663.A0A177C8E3"/>
    <dbReference type="GeneID" id="28767747"/>
    <dbReference type="InParanoid" id="A0A177C8E3"/>
    <dbReference type="OrthoDB" id="5407653at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048315">
        <property type="term" value="P:conidium formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.260.10">
        <property type="entry name" value="Transcription regulator HTH, APSES-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029790">
        <property type="entry name" value="EFG1/Phd1/StuA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036887">
        <property type="entry name" value="HTH_APSES_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018004">
        <property type="entry name" value="KilA/APSES_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003163">
        <property type="entry name" value="Tscrpt_reg_HTH_APSES-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47792">
        <property type="entry name" value="PROTEIN SOK2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47792:SF1">
        <property type="entry name" value="PROTEIN SOK2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04383">
        <property type="entry name" value="KilA-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01252">
        <property type="entry name" value="KilA-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54616">
        <property type="entry name" value="DNA-binding domain of Mlu1-box binding protein MBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51299">
        <property type="entry name" value="HTH_APSES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0183">Conidiation</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0749">Sporulation</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH APSES-type" evidence="8">
        <location>
            <begin position="282"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="56"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="405"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="499"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="73"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="117"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="174"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="412"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="475"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="499"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="531"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="659"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="673"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="778"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAG03401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="790" mass="83855" checksum="2A2BEB0F8AA25A85" modified="2016-09-07" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C9A3</accession>
    <name>A0A177C9A3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_863426</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG03701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034066.1">
        <property type="nucleotide sequence ID" value="XM_018187689.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C9A3"/>
    <dbReference type="GeneID" id="28771175"/>
    <dbReference type="InParanoid" id="A0A177C9A3"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG03701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="99" mass="11940" checksum="82D8ECA3A49E67D7" modified="2016-09-07" version="1">MALMNGHMMPQSIPRQGLRTRNSFAWARLAPSLVFEYRSRERLIPMRYPSVFEYRSRERLIPMRYPSRQPPHPTHHVDHHRSASLERPTWTMPAHFFRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C9G5</accession>
    <name>A0A177C9G5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CC84DRAFT_1096047</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NADH dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG03479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033844.1">
        <property type="nucleotide sequence ID" value="XM_018174644.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C9G5"/>
    <dbReference type="STRING" id="1460663.A0A177C9G5"/>
    <dbReference type="GeneID" id="28758130"/>
    <dbReference type="InParanoid" id="A0A177C9G5"/>
    <dbReference type="OrthoDB" id="9992747at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003954">
        <property type="term" value="F:NADH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045024">
        <property type="entry name" value="NDH-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054585">
        <property type="entry name" value="NDH2-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43706">
        <property type="entry name" value="NADH DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43706:SF17">
        <property type="entry name" value="NADH DEHYDROGENASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22366">
        <property type="entry name" value="NDH2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="7">
        <location>
            <begin position="19"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="External alternative NADH-ubiquinone oxidoreductase-like C-terminal" evidence="8">
        <location>
            <begin position="446"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="109"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF22366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAG03479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="510" mass="57191" checksum="86BEF482255A2DAA" modified="2016-09-07" version="1">MALLQRFLRLIAFQTERERVVILGSGWAGYTVARGLDPKKYQAVVVSPRSYFAFTPLLASTSVGTLEFRTAMEPIRTRRTHVDFFQGWADQVDFKNKKITIEEAVEERAQSTAGVEERDAGESKEHRHERREVEVQKGKLFDLTYDKLIVTVGCYSQTFGTPGVKEHAMFLKDVGDARKIRNRILACFETAALPTTTDEQRKQLLNFAIVGGGPTGIEFSAELHDIITEDLARIYPELVKFSKITVYDVAKKVLPMFDEKLAQYAMDTFAREGIDIKTDHHVEELRPGAPDENVSSKDDHLVYTLKVKEGGALGVGMVVWSTGLMQNPFVANALSHVHEIPNDFRRLEGPSNDPGNLHWCVKIDEKTGSVVTDTRLRLKLVADTKEDTKPEAILDDVFVLGDCAIMEGTQYPATAQVAAQKASWLAKRLNKGDIEKTSGFAWRNMGVMAYIGNWNALLQGGGNTGGISGRLAWIVWRGAYLTKSVSWRNKILIPVYWAINWLFGRDVSRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C9H8</accession>
    <name>A0A177C9H8_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 19">Autophagy-related protein 9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">CC84DRAFT_1197197</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="19">Phospholipid scramblase involved in autophagy. Cycles between the preautophagosomal structure/phagophore assembly site (PAS) and the cytoplasmic vesicle pool and supplies membrane for the growing autophagosome. Lipid scramblase activity plays a key role in preautophagosomal structure/phagophore assembly by distributing the phospholipids that arrive through ATG2 from the cytoplasmic to the luminal leaflet of the bilayer, thereby driving autophagosomal membrane expansion.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate)(in) = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate)(out)</text>
            <dbReference type="Rhea" id="RHEA:67920"/>
            <dbReference type="ChEBI" id="CHEBI:58088"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-L-serine(in) = a 1,2-diacyl-sn-glycero-3-phospho-L-serine(out)</text>
            <dbReference type="Rhea" id="RHEA:38663"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>a 1,2-diacyl-sn-glycero-3-phosphocholine(in) = a 1,2-diacyl-sn-glycero-3-phosphocholine(out)</text>
            <dbReference type="Rhea" id="RHEA:38571"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out)</text>
            <dbReference type="Rhea" id="RHEA:38895"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Golgi apparatus membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3 19">Preautophagosomal structure membrane</location>
            <topology evidence="3 19">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 19">Belongs to the ATG9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG03428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033793.1">
        <property type="nucleotide sequence ID" value="XM_018181509.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C9H8"/>
    <dbReference type="FunCoup" id="A0A177C9H8">
        <property type="interactions" value="229"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177C9H8"/>
    <dbReference type="GeneID" id="28764995"/>
    <dbReference type="InParanoid" id="A0A177C9H8"/>
    <dbReference type="OrthoDB" id="2020634at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005776">
        <property type="term" value="C:autophagosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034497">
        <property type="term" value="P:protein localization to phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061709">
        <property type="term" value="P:reticulophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007241">
        <property type="entry name" value="Autophagy-rel_prot_9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13038">
        <property type="entry name" value="APG9 AUTOPHAGY 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13038:SF10">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04109">
        <property type="entry name" value="ATG9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 19" id="KW-0072">Autophagy</keyword>
    <keyword evidence="14" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="11" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="12 19" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="13 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 19" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7 19" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="226"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="271"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="443"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="528"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="65"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="733"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="32"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="154"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00024479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00024615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00024621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00024631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU364027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="OAG03428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="880" mass="100417" checksum="EB45A5E5656EB58C" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CBA8</accession>
    <name>A0A177CBA8_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1063954</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG04058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034423.1">
        <property type="nucleotide sequence ID" value="XM_018173619.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CBA8"/>
    <dbReference type="STRING" id="1460663.A0A177CBA8"/>
    <dbReference type="GeneID" id="28757105"/>
    <dbReference type="InParanoid" id="A0A177CBA8"/>
    <dbReference type="OrthoDB" id="2159786at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070860">
        <property type="term" value="C:RNA polymerase I core factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001164">
        <property type="term" value="F:RNA polymerase I core promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001181">
        <property type="term" value="F:RNA polymerase I general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042790">
        <property type="term" value="P:nucleolar large rRNA transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053029">
        <property type="entry name" value="RNA_pol_I-specific_init_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007224">
        <property type="entry name" value="TIF_Rrn11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28244">
        <property type="entry name" value="RNA POLYMERASE I-SPECIFIC TRANSCRIPTION INITIATION FACTOR RRN11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28244:SF1">
        <property type="entry name" value="RNA POLYMERASE I-SPECIFIC TRANSCRIPTION INITIATION FACTOR RRN11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04090">
        <property type="entry name" value="Rrn11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG04058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="183" mass="21504" checksum="3D871F838DA03D4C" modified="2016-09-07" version="1" fragment="single">LSTIMHRCLLEGDYQRASRAWGMILRTEAHGTPIEPRYNGLWGLGAELLLRRRSGDEQDRPLSDEYQYSEDGFQLAKDYYERLILQYPVRNFQPHAIDATIFYPPLFSVWIMQVLERSRRERRRLTDDEAATSEDRHKMQQEELAGAREICRRLEELVQSPPYDKNAQLLVLRGHAGLWVSDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2023-06-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CCP1</accession>
    <name>A0A177CCP1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_721556</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG05403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035768.1">
        <property type="nucleotide sequence ID" value="XM_018187165.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CCP1"/>
    <dbReference type="GeneID" id="28770651"/>
    <dbReference type="InParanoid" id="A0A177CCP1"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG05403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="251" mass="28070" checksum="2E009F8CF5C6D3FF" modified="2016-09-07" version="1">MPEREHLSVTVAEPKAWRHERQVPLGADCMKCQPESWKLMKDASRNTRKVISQGPIREPAHCAIPAMGCMIRWDLRPSRWRVPEECFWEPCMRVPKPCIKPSPPWRSRGGTTSGGGAAQTFHRESKYQKMTGWGEVVSLRTKKVCSRVDVGRSGADLMIDAMPEILLCASTSMRQRSDFAYITFLGSTIPLTQTYSRTVEVVLVVSRSISLPPIACCMHSETAFCVVSCFSRPSREGSKTNASVTRLLAHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CDH0</accession>
    <name>A0A177CDH0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WD repeat-containing protein 26</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CC84DRAFT_1187720</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG04750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035115.1">
        <property type="nucleotide sequence ID" value="XM_018180951.1"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CDH0"/>
    <dbReference type="GeneID" id="28764437"/>
    <dbReference type="InParanoid" id="A0A177CDH0"/>
    <dbReference type="OrthoDB" id="65569at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034657">
        <property type="term" value="C:GID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033132">
        <property type="entry name" value="GH_1_N_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001360">
        <property type="entry name" value="Glyco_hydro_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051350">
        <property type="entry name" value="WD_repeat-ST_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22838">
        <property type="entry name" value="WD REPEAT PROTEIN 26-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22838:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00232">
        <property type="entry name" value="Glyco_hydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23627">
        <property type="entry name" value="LisH_WDR26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00131">
        <property type="entry name" value="GLHYDRLASE1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00653">
        <property type="entry name" value="GLYCOSYL_HYDROL_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008058065" evidence="5">
        <location>
            <begin position="21"/>
            <end position="1286"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="990"/>
            <end position="1031"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1032"/>
            <end position="1075"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1251"/>
            <end position="1286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="595"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="621"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="665"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="677"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="693"/>
            <end position="705"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAG04750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="1286" mass="142535" checksum="12A6D091E4A7FBAE" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CDP9</accession>
    <name>A0A177CDP9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Replication factor C subunit 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CC84DRAFT_1165269</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the activator 1 small subunits family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG04907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035272.1">
        <property type="nucleotide sequence ID" value="XM_018178680.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CDP9"/>
    <dbReference type="FunCoup" id="A0A177CDP9">
        <property type="interactions" value="829"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CDP9"/>
    <dbReference type="GeneID" id="28762166"/>
    <dbReference type="InParanoid" id="A0A177CDP9"/>
    <dbReference type="OrthoDB" id="761538at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031390">
        <property type="term" value="C:Ctf18 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005663">
        <property type="term" value="C:DNA replication factor C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031391">
        <property type="term" value="C:Elg1 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031389">
        <property type="term" value="C:Rad17 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003689">
        <property type="term" value="F:DNA clamp loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000030">
        <property type="entry name" value="replication factor C subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.272.10:FF:000002">
        <property type="entry name" value="Replication factor C subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000136">
        <property type="entry name" value="Replication factor C subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.272.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050238">
        <property type="entry name" value="DNA_Rep/Repair_Clamp_Loader"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669">
        <property type="entry name" value="REPLICATION FACTOR C / DNA POLYMERASE III GAMMA-TAU SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669:SF1">
        <property type="entry name" value="REPLICATION FACTOR C SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13177">
        <property type="entry name" value="DNA_pol3_delta2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21960">
        <property type="entry name" value="RCF1-5-like_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22534">
        <property type="entry name" value="RFC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="post-AAA+ oligomerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="6">
        <location>
            <begin position="34"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00070185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAG04907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="353" mass="39940" checksum="1AE6E5FAF4B97C36" modified="2016-09-07" version="1">MALLVDKHRPRSLEALSYHPDLSDRLRSLAQSGDFPHLLVYGPSGAGKKTRIVATLKELYGPGVEKIKIDARVFQTTSNRKLEFNIVASVYHLEITPSDVGNYDRVVVQDLLKEVAQTQQVDLNAKQRFKVVVINEADHLTRDAQAALRRTMEKYSPNLRLILLANSTSNIIAPIRSRTLLVRVAAPTEEEICGVLRVVGKKEGWKEVDGLNKRVAKESGRNLRKALLMFEAVHAQNENITDTTHIPPPDWEALISQIANQIVEERSPARLLQVRAALYDLLSHCIDPTTILKTLTWKLIPKTDDALKPEVIKWAAFYEHRCKTGSKVIFHLEAFVAKYMRLYESFLMGVDFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CE11</accession>
    <name>A0A177CE11_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1177089</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG04960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035325.1">
        <property type="nucleotide sequence ID" value="XM_018180261.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CE11"/>
    <dbReference type="GeneID" id="28763747"/>
    <dbReference type="InParanoid" id="A0A177CE11"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG04960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="217" mass="24224" checksum="5F89ABA980ED72A8" modified="2016-09-07" version="1">MPPHHQKVNPPSSNARTLSVPVNKASSDTEQTTTSAQITHQSRMDNRNGASSKSPHSATEISHKPVARGYDKYGRYWYDRKILREEGLCFKCGEPYHRASDMNALGRIAVARTIARSPPLLTFQYGDAGTGGDDENESEYNDETRYHNEREREGESEDDGSESSEGSPRQEAFTSMPTPPPSQTSTDRPSGNRARSESPGKEKAAVHRWVERFESPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CEA5</accession>
    <name>A0A177CEA5_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Thioredoxin peroxidase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Thioredoxin-dependent peroxiredoxin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CC84DRAFT_1165466</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the peroxiredoxin family. Prx5 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG05139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035504.1">
        <property type="nucleotide sequence ID" value="XM_018178720.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CEA5"/>
    <dbReference type="FunCoup" id="A0A177CEA5">
        <property type="interactions" value="576"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CEA5"/>
    <dbReference type="GeneID" id="28762206"/>
    <dbReference type="InParanoid" id="A0A177CEA5"/>
    <dbReference type="OrthoDB" id="195498at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008379">
        <property type="term" value="F:thioredoxin peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03013">
        <property type="entry name" value="PRX5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000020">
        <property type="entry name" value="Peroxiredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037944">
        <property type="entry name" value="PRX5-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013740">
        <property type="entry name" value="Redoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10430">
        <property type="entry name" value="PEROXIREDOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10430:SF16">
        <property type="entry name" value="PEROXIREDOXIN-5, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08534">
        <property type="entry name" value="Redoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="4 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 9" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="5 9" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="10">
        <location>
            <begin position="4"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate" evidence="8">
        <location>
            <position position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00079296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR637944-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU366011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OAG05139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="167" mass="18207" checksum="4177D404927BC8B7" modified="2016-09-07" version="1">MAPLKVGDSFPDGVKFEWAPITDGDATACGIPQEYDASKEWKDKKVVLFSVPGAFTPGCQARHLPPYIEKLSEFKNKGVDVVATIASNDSWVMNAWGKVNGVKGDDILFLSDTKTFFSREHGWPAGMGDRNGRWAMVFDHGKVIYAENEPSPKDVSVSGAEAVLAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CF37</accession>
    <name>A0A177CF37_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">25S rRNA (uridine-N(3))-methyltransferase BMT5-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_720902</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG05367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035732.1">
        <property type="nucleotide sequence ID" value="XM_018187157.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CF37"/>
    <dbReference type="FunCoup" id="A0A177CF37">
        <property type="interactions" value="207"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CF37"/>
    <dbReference type="GeneID" id="28770643"/>
    <dbReference type="InParanoid" id="A0A177CF37"/>
    <dbReference type="OrthoDB" id="273345at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070042">
        <property type="term" value="F:rRNA (uridine-N3-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019446">
        <property type="entry name" value="BMT5-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538:SF26">
        <property type="entry name" value="FERREDOXIN-FOLD ANTICODON-BINDING DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538">
        <property type="entry name" value="PHENYLALANYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10354">
        <property type="entry name" value="BMT5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="25S rRNA (uridine-N(3))-methyltransferase BMT5-like" evidence="2">
        <location>
            <begin position="78"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="282"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="25"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="282"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG05367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="310" mass="34341" checksum="502E4D3F8F4DF2B2" modified="2016-09-07" version="1">MSKTKTKRARRELKRDATRKIANFQKAAAKSVPKPSAPAAKKQKPNNDPKPPATAVPKPPVQASQKHEVPFGTYDHILLVGEGDFSFTKSLVSEHGCANVTATSFDSDEEVRAKYPTFASIHDELSALTPPVPFHSSVDATKLGSYKALRSSEEREGGWDTIAFMFPHTGGLSTDVNRQVRANQALLVGFFNSCLSAHKGRPFLRDGGRVLVCLFEGEPYTLWNVRDLARHAGLKVVESYKFDSKDYPGYAHVRTLGAIEGGGAWKGEDRRARMFVFEKVGEKKKEEEEGEKKWGKKRARDESESDSDEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CF82</accession>
    <name>A0A177CF82_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">A1pp-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1119613</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG05996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036361.1">
        <property type="nucleotide sequence ID" value="XM_018175555.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CF82"/>
    <dbReference type="STRING" id="1460663.A0A177CF82"/>
    <dbReference type="GeneID" id="28759041"/>
    <dbReference type="InParanoid" id="A0A177CF82"/>
    <dbReference type="OrthoDB" id="6077599at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02908">
        <property type="entry name" value="Macro_OAADPr_deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="entry name" value="Leucine Aminopeptidase, subunit E, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002589">
        <property type="entry name" value="Macro_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11106">
        <property type="entry name" value="GANGLIOSIDE INDUCED DIFFERENTIATION ASSOCIATED PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11106:SF27">
        <property type="entry name" value="MACRO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01661">
        <property type="entry name" value="Macro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00506">
        <property type="entry name" value="A1pp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="Macro domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51154">
        <property type="entry name" value="MACRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Macro" evidence="2">
        <location>
            <begin position="28"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="245"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="268"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG05996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="282" mass="30244" checksum="4147855B41B3E8D1" modified="2016-09-07" version="1">MADMQLDEIPTLSLLYKLSRIPLDADHPSPCEPNAAYNDKISIIKADITSLVVDGIVNAANEALLGGGGVDGAIHRAAGPDLVRECRGLNGCEAGDAKITDGYKLPSEKVIHAVGPRWYALSPEDAEAKLKSCYRRGLELAVEHDLKSIAFPAISTGVFSYPNVKACNDALSEVRKFLDEGKGDGLQRIIFCNFLQKDQDIYYKHVSKHFPPVPAPAPEETNAAAKTSTDEADIAAKLPDPPTSEPKDPEEPSAKKQKTEAAADDLVAVDKDEAKGTPKGEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2023-06-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CFF8</accession>
    <name>A0A177CFF8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1164437</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG06076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036441.1">
        <property type="nucleotide sequence ID" value="XM_018178487.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CFF8"/>
    <dbReference type="GeneID" id="28761973"/>
    <dbReference type="InParanoid" id="A0A177CFF8"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG06076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="77" mass="8625" checksum="2DAFC772ADB6183E" modified="2016-09-07" version="1">MDSSQRNSTHEDIDGGWELEDGKSTVCSQIADLPLIVVGEIVGVLRAKGIEELNFSQSQRSTFYPPLLGYKHRFQTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CFV3</accession>
    <name>A0A177CFV3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Acireductone dioxygenase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Acireductone dioxygenase (Fe(2+)-requiring)</fullName>
            <shortName evidence="11">ARD'</shortName>
            <shortName evidence="11">Fe-ARD</shortName>
            <ecNumber evidence="11">1.13.11.54</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Acireductone dioxygenase (Ni(2+)-requiring)</fullName>
            <shortName evidence="11">ARD</shortName>
            <shortName evidence="11">Ni-ARD</shortName>
            <ecNumber evidence="11">1.13.11.53</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">ADI1</name>
        <name evidence="12" type="ORF">CC84DRAFT_1164155</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes 2 different reactions between oxygen and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4-methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + O2 = 3-(methylsulfanyl)propanoate + CO + formate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:14161"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:17245"/>
            <dbReference type="ChEBI" id="CHEBI:49016"/>
            <dbReference type="ChEBI" id="CHEBI:49252"/>
            <dbReference type="EC" id="1.13.11.53"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + O2 = 4-methylsulfanyl-2-oxobutanoate + formate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:24504"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:16723"/>
            <dbReference type="ChEBI" id="CHEBI:49252"/>
            <dbReference type="EC" id="1.13.11.54"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <cofactor evidence="11">
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
        </cofactor>
        <text evidence="11">Binds either 1 Fe or Ni cation per monomer. Iron-binding promotes an acireductone dioxygenase reaction producing 2-keto-4-methylthiobutyrate, while nickel-binding promotes an acireductone dioxygenase reaction producing 3-(methylsulfanyl)propanoate.</text>
    </comment>
    <comment type="pathway">
        <text evidence="11">Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 5/6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the acireductone dioxygenase (ARD) family.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.54" evidence="11"/>
    <dbReference type="EC" id="1.13.11.53" evidence="11"/>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG05688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036053.1">
        <property type="nucleotide sequence ID" value="XM_018178430.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CFV3"/>
    <dbReference type="FunCoup" id="A0A177CFV3">
        <property type="interactions" value="261"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CFV3"/>
    <dbReference type="GeneID" id="28761916"/>
    <dbReference type="InParanoid" id="A0A177CFV3"/>
    <dbReference type="OrthoDB" id="1867259at2759"/>
    <dbReference type="UniPathway" id="UPA00904">
        <property type="reaction ID" value="UER00878"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010308">
        <property type="term" value="F:acireductone dioxygenase (Ni2+-requiring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010309">
        <property type="term" value="F:acireductone dioxygenase [iron(II)-requiring] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019509">
        <property type="term" value="P:L-methionine salvage from methylthioadenosine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02232">
        <property type="entry name" value="cupin_ARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000079">
        <property type="entry name" value="1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03154">
        <property type="entry name" value="Salvage_MtnD_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004313">
        <property type="entry name" value="ARD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027496">
        <property type="entry name" value="ARD_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23418">
        <property type="entry name" value="ACIREDUCTONE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23418:SF0">
        <property type="entry name" value="ACIREDUCTONE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03079">
        <property type="entry name" value="ARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 11 12" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="8 11" id="KW-0408">Iron</keyword>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 11" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="3 11" id="KW-0533">Nickel</keyword>
    <keyword evidence="10 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="11">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <note>for iron-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <note>for nickel-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <note>for iron-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <note>for nickel-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <note>for iron-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <note>for nickel-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <note>for iron-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <note>for nickel-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OAG05688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="175" mass="20527" checksum="AAB0F30E68D74F4E" modified="2016-09-07" version="1">MKAYWYDNLPGDQRAPHDSGREVSPDSLKQLGILFKHCPSVADVDEIATSRSYKNRDEITVSPQTMGAAYEEKVKNFFHEHLHEDEEIRYILNGAGYFDVRNEGDEWVRIRLEKGDLIVMPAGIYHRFTTDEENFTNAMRLFKEDPKWTPLNRGEETEKNQYRQEYLKTRHTLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CGH9</accession>
    <name>A0A177CGH9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Polysaccharide deacetylase family protein-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1119268</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG05807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036172.1">
        <property type="nucleotide sequence ID" value="XM_018175546.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CGH9"/>
    <dbReference type="GeneID" id="28759032"/>
    <dbReference type="InParanoid" id="A0A177CGH9"/>
    <dbReference type="OrthoDB" id="3162524at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10938">
        <property type="entry name" value="CE4_HpPgdA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.370">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037950">
        <property type="entry name" value="PgdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47561">
        <property type="entry name" value="POLYSACCHARIDE DEACETYLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G05030)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47561:SF1">
        <property type="entry name" value="POLYSACCHARIDE DEACETYLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G05030)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NodB homology" evidence="2">
        <location>
            <begin position="29"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="288"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="304"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG05807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="313" mass="35544" checksum="90121EF6F73C8008" modified="2016-09-07" version="1">MGKKRVLISYGVDVDAVAGWLGSYGGEDSTSDISRGLWAGTVGTQRLLKMFAKHDIKTTWFIPGHSLETFPEDMAAVRDAGHEIGLHGYSHENPVDMTLEQQRDVLDKTYRMLTEFAGKPPRGSVAPWWETSQEGAELLLSYGIEYDHSMSHHDCQAYYLRTGDSWTKIDYSKKAAEWMKPLVKGQETGLVEIPANWYIDDLPPMMFIKASSNSHGFVNARDIEDIWRDHFDYFYQEYDDFIFPITIHPDVSGRPHALLMHERLIKHFKEHEGVEFVTMEQICDEFKSKNAPPEGALMPAEPGAKLKEAPVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2023-06-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CGR2</accession>
    <name>A0A177CGR2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_763766</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG06411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036776.1">
        <property type="nucleotide sequence ID" value="XM_018187350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CGR2"/>
    <dbReference type="GeneID" id="28770836"/>
    <dbReference type="InParanoid" id="A0A177CGR2"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG06411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="182" mass="20276" checksum="08C7ABEBCC28A230" modified="2016-09-07" version="1">MTYDVRPPSVLDHPPSSNHAPVLRAACNPRFLAMTRYQPPSKPSTGMHTPKLGPRLSQDPINLIYAAAHNLHAEAPTSRASSHDDLSIPIPIPHRFRILSPNTTLRHCMLRTSKRVQRYKSRVNKEVLKMAQGYGRRWYLGGTTTAVHIRRSLSSYRRSPFRTSHPLQPAALASARSGCAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CH52</accession>
    <name>A0A177CH52_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Ketoacyl-synt-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CC84DRAFT_1259445</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the carnitine/choline acetyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG06188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036553.1">
        <property type="nucleotide sequence ID" value="XM_018184913.1"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CH52"/>
    <dbReference type="GeneID" id="28768399"/>
    <dbReference type="InParanoid" id="A0A177CH52"/>
    <dbReference type="OrthoDB" id="329835at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05195">
        <property type="entry name" value="enoyl_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.70">
        <property type="entry name" value="Choline/Carnitine o-acyltransferase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000542">
        <property type="entry name" value="Carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039551">
        <property type="entry name" value="Cho/carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042231">
        <property type="entry name" value="Cho/carn_acyl_trans_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049551">
        <property type="entry name" value="PKS_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049552">
        <property type="entry name" value="PKS_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF22">
        <property type="entry name" value="SYNTHASE, PUTATIVE (JCVI)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23297">
        <property type="entry name" value="ACP_SdgA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00755">
        <property type="entry name" value="Carn_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21089">
        <property type="entry name" value="PKS_DH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00440">
        <property type="entry name" value="ACYLTRANSF_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="2" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="11">
        <location>
            <begin position="8"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="12">
        <location>
            <begin position="921"/>
            <end position="1239"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="10">
        <location>
            <begin position="1655"/>
            <end position="1736"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="8">
        <location>
            <begin position="921"/>
            <end position="1060"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="8">
        <location>
            <begin position="1089"/>
            <end position="1239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1747"/>
            <end position="1796"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1759"/>
            <end position="1775"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for dehydratase activity" evidence="8">
        <location>
            <position position="953"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for dehydratase activity" evidence="8">
        <location>
            <position position="1154"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="2128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR600542-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OAG06188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="2400" mass="259244" checksum="74044D217F021BBE" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CHB5</accession>
    <name>A0A177CHB5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ubiquitin ligase complex F-box protein GRR1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CC84DRAFT_1217501</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG06248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036613.1">
        <property type="nucleotide sequence ID" value="XM_018182897.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CHB5"/>
    <dbReference type="STRING" id="1460663.A0A177CHB5"/>
    <dbReference type="GeneID" id="28766383"/>
    <dbReference type="InParanoid" id="A0A177CHB5"/>
    <dbReference type="OrthoDB" id="10257471at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000251">
        <property type="entry name" value="Ubiquitin ligase complex F-box protein GRR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050648">
        <property type="entry name" value="F-box_LRR-repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057207">
        <property type="entry name" value="FBXL15_LRR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006553">
        <property type="entry name" value="Leu-rich_rpt_Cys-con_subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13382">
        <property type="entry name" value="MITOCHONDRIAL ATP SYNTHASE COUPLING FACTOR B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13382:SF67">
        <property type="entry name" value="SCF E3 UBIQUITIN LIGASE COMPLEX F-BOX PROTEIN POF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25372">
        <property type="entry name" value="DUF7885"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00367">
        <property type="entry name" value="LRR_CC"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="7" id="KW-0436">Ligase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="F-box" evidence="5">
        <location>
            <begin position="76"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="F-box/LRR-repeat protein 15-like leucin rich repeat" evidence="6">
        <location>
            <begin position="244"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="16"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="39"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF25372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAG06248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="603" mass="67338" checksum="F5756D52EC96E1EF" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CHG3</accession>
    <name>A0A177CHG3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Meiotically up-regulated gene 56 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_1176226</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG06177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036542.1">
        <property type="nucleotide sequence ID" value="XM_018180206.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CHG3"/>
    <dbReference type="FunCoup" id="A0A177CHG3">
        <property type="interactions" value="7"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CHG3"/>
    <dbReference type="GeneID" id="28763692"/>
    <dbReference type="InParanoid" id="A0A177CHG3"/>
    <dbReference type="OrthoDB" id="5579281at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005628">
        <property type="term" value="C:prospore membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902657">
        <property type="term" value="P:protein localization to prospore membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040345">
        <property type="entry name" value="Mug56/Spo71"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039486">
        <property type="entry name" value="Mug56/Spo71_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057379">
        <property type="entry name" value="PH_SPO71"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029217">
        <property type="entry name" value="Spo7_2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28076:SF1">
        <property type="entry name" value="PROSPORE MEMBRANE ADAPTER PROTEIN SPO71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28076">
        <property type="entry name" value="SPORULATION-SPECIFIC PROTEIN 71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15404">
        <property type="entry name" value="PH_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23207">
        <property type="entry name" value="PH_SPO71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15407">
        <property type="entry name" value="Spo7_2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01316">
        <property type="entry name" value="Spo7_2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sporulation-specific protein 71 N-terminal" evidence="3">
        <location>
            <begin position="14"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="648"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="923"/>
            <end position="1100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="689"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1111"/>
            <end position="1133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="91"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="225"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="276"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="692"/>
            <end position="701"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAG06177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1133" mass="127653" checksum="EDB83E6D2CA35993" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CHP0</accession>
    <name>A0A177CHP0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1245481</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG06287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036652.1">
        <property type="nucleotide sequence ID" value="XM_018184183.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CHP0"/>
    <dbReference type="GeneID" id="28767669"/>
    <dbReference type="InParanoid" id="A0A177CHP0"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="123"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG06287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="303" mass="32649" checksum="2C9729E3657000E4" modified="2016-09-07" version="1">MRQDAMHPARRTLTDDYTDAWEQREVVGGAVTDAHVEPGVCQHGTESRGGGCIQGRAGRVRRRRKSNARGRRRAAQGQGGGGWRLVLEERTSALIPTARDRAVREKATGNRTRGSAGRREFQRPSGAGRASHAGRSAWLRPRLVLLGLVVSVGTHTGAVWPAVADTVSSQPKVIDKRATPPRARPRGMGLCREISPARESRQPCGRAVCSVAVSQRLALLQHPWLATLVLGLSCRSMLHNLAKGLSRGCFNVFPAALHRGLSPGTSWSRAWIPKALSLISICLVAGPGERVSRQAPLTSAAFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CHV0</accession>
    <name>A0A177CHV0_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cytochrome c oxidase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_1163339</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Energy metabolism; oxidative phosphorylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome c oxidase subunit 6B family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG07105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037470.1">
        <property type="nucleotide sequence ID" value="XM_018178245.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CHV0"/>
    <dbReference type="FunCoup" id="A0A177CHV0">
        <property type="interactions" value="419"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CHV0"/>
    <dbReference type="GeneID" id="28761731"/>
    <dbReference type="InParanoid" id="A0A177CHV0"/>
    <dbReference type="OrthoDB" id="1107506at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045277">
        <property type="term" value="C:respiratory chain complex IV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006123">
        <property type="term" value="P:mitochondrial electron transport, cytochrome c to oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00926">
        <property type="entry name" value="Cyt_c_Oxidase_VIb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.140:FF:000001">
        <property type="entry name" value="Cytochrome c oxidase subunit 6B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.140">
        <property type="entry name" value="Cytochrome c oxidase, subunit VIb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048280">
        <property type="entry name" value="COX6B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036549">
        <property type="entry name" value="CX6/COA6-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003213">
        <property type="entry name" value="Cyt_c_oxidase_su6B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46281:SF8">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 12, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46281">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02297">
        <property type="entry name" value="COX6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000278">
        <property type="entry name" value="Cyt_c_oxidase_6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47694">
        <property type="entry name" value="Cytochrome c oxidase subunit h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="30"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="40"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR000278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000278-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAG07105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="85" mass="10116" checksum="E7DC1699F566CC2D" modified="2016-09-07" version="1">MSDEETETKPFKFVTGFDARFPNQNQTKHCWQNYVDYHKCITAKGEDFAPCRQFLLAYRSLCPSGWTSRWDDQREKGIFPCRLDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CJ52</accession>
    <name>A0A177CJ52_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_655429</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG07346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037711.1">
        <property type="nucleotide sequence ID" value="XM_018187022.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CJ52"/>
    <dbReference type="GeneID" id="28770508"/>
    <dbReference type="InParanoid" id="A0A177CJ52"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG07346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="72" mass="7466" checksum="94E60C171242D3E4" modified="2016-09-07" version="1">MPKVFLAVTIGEAGGLEVQWRKIMFPGFAGRGSAAWLHCGGVDMGHFAVIPSVISAALAILCQGLNCVLHSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CJ64</accession>
    <name>A0A177CJ64_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CC84DRAFT_1089625</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG07574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037939.1">
        <property type="nucleotide sequence ID" value="XM_018174318.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CJ64"/>
    <dbReference type="GeneID" id="28757804"/>
    <dbReference type="InParanoid" id="A0A177CJ64"/>
    <dbReference type="OrthoDB" id="5596576at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059065">
        <property type="entry name" value="Ig_Tag1-like_4th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059066">
        <property type="entry name" value="Ig_Tag1-like_5th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046368">
        <property type="entry name" value="Tag1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055011">
        <property type="entry name" value="Tag1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35895">
        <property type="entry name" value="CHROMOSOME 16, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35895:SF3">
        <property type="entry name" value="PRE-RRNA PROCESSING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26174">
        <property type="entry name" value="LEA-2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26150">
        <property type="entry name" value="LEA-2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26153">
        <property type="entry name" value="LEA-2L_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22786">
        <property type="entry name" value="Tag1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117070">
        <property type="entry name" value="LEA14-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tag1 C-terminal" evidence="2">
        <location>
            <begin position="370"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="domain" description="Tag1-like fourth Ig-like" evidence="3">
        <location>
            <begin position="506"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="domain" description="Tag1-like fifth Ig-like" evidence="4">
        <location>
            <begin position="654"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="635"/>
            <end position="654"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF26150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF26153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAG07574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="777" mass="83855" checksum="2DDC3F401463145C" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CJ83</accession>
    <name>A0A177CJ83_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Di-copper centre-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CC84DRAFT_629931</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG06880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037245.1">
        <property type="nucleotide sequence ID" value="XM_018186940.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CJ83"/>
    <dbReference type="STRING" id="1460663.A0A177CJ83"/>
    <dbReference type="GeneID" id="28770426"/>
    <dbReference type="InParanoid" id="A0A177CJ83"/>
    <dbReference type="OrthoDB" id="6132182at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1280.10">
        <property type="entry name" value="Di-copper center containing domain from catechol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008922">
        <property type="entry name" value="Di-copper_centre_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050316">
        <property type="entry name" value="Tyrosinase/Hemocyanin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002227">
        <property type="entry name" value="Tyrosinase_Cu-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474:SF116">
        <property type="entry name" value="TYROSINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474">
        <property type="entry name" value="TYROSINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00264">
        <property type="entry name" value="Tyrosinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00092">
        <property type="entry name" value="TYROSINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48056">
        <property type="entry name" value="Di-copper centre-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00497">
        <property type="entry name" value="TYROSINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00498">
        <property type="entry name" value="TYROSINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008058276" evidence="2">
        <location>
            <begin position="19"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosinase copper-binding" evidence="3">
        <location>
            <begin position="133"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosinase copper-binding" evidence="4">
        <location>
            <begin position="330"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAG06880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="410" mass="43832" checksum="E30F905E27039C6F" modified="2016-09-07" version="1">MRFTTSVALCLVAALSNAIPTPQTDGSAADLPTQASPDEAQALEQLAQLAEFAGQTTNETLAANKKRDGCSLGNLSIRREWSTLSKPQRKAYTDAVLCLQKLPARTPSSVIPGAKSRFDDFVGTHIQQANYIHYSGTFLAWHRYFTWSYEQALRNECGYNGVQPYWNWASSGAVGLANSAILDGSAYSMSGDGQYVEKTGDIILGGAEGLPPLVLPTGSGGGCVKSGPFVNMSVNLGPVGLSLPGGGYEVNGDGLSYNPRCLKRDLTDAVVRKYSNATAIAYTILKPQEVYDFQMTMQGVPGSGNIGIHGGGHYAMGGDPGRDVNTSPGDPLFYTHHAMIDRVWWIWQLLDKKERTGAKGISGTGTFLNMPPSANTTLDTVIDLGYAAGPPVTMRDLMSTTDGPFCYAYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CKL2</accession>
    <name>A0A177CKL2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1175201</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG07379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037744.1">
        <property type="nucleotide sequence ID" value="XM_018180137.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CKL2"/>
    <dbReference type="GeneID" id="28763623"/>
    <dbReference type="InParanoid" id="A0A177CKL2"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="200"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG07379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="248" mass="28097" checksum="EB0B324439A916A2" modified="2016-09-07" version="1">MAYQSQQASPSPLHIDAPKSFQSDNMTTSNETIPTNQNTNNNHAVKQRPPHPRLGRRLQRRKCAVGSSATEPAWLLSQPHGSASPRYNRQLPRCSQCALICRSGQSPRRTNTYKTRRASQKSPWKAQRISPVIQHVEPSLYASQSLSITQSQIMPRRSTRLIHDWDDGFNNGYPEWTPLYPDWTPIINRNYGYVRDVPPLRRPGRPGRRCGAHGDAISMEPSAGQGARRAGEWSSRAPRWLGEAWGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CKR7</accession>
    <name>A0A177CKR7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">aldehyde dehydrogenase (NAD(+))</fullName>
            <ecNumber evidence="5">1.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CC84DRAFT_1085769</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>an aldehyde + NAD(+) + H2O = a carboxylate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:16185"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.2.1.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.3" evidence="5"/>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038499.1">
        <property type="nucleotide sequence ID" value="XM_018174114.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CKR7"/>
    <dbReference type="STRING" id="1460663.A0A177CKR7"/>
    <dbReference type="GeneID" id="28757600"/>
    <dbReference type="InParanoid" id="A0A177CKR7"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07090">
        <property type="entry name" value="ALDH_F9_TMBADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000014">
        <property type="entry name" value="NAD/NADP-dependent betaine aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000007">
        <property type="entry name" value="NAD/NADP-dependent betaine aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009725">
        <property type="entry name" value="PRK13252.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11699">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="3 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="9">
        <location>
            <begin position="20"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAG08134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="505" mass="53677" checksum="31E375BB7AF2ED64" modified="2016-09-07" version="1">MSLPYPPRSAYYDGKLQSASSTSSFQTIDPATAKPLANIHTTSQSGIDAAVASAKKAFPAWSATPHIERARILQKAAAILRARNDELAKVETHDTGKAFSETSTVDVVTGADVLEYFANMVGGGGLNGETIQLRPNAWVYTTKNALGVCAGIGAWNYPIQIALWKSAPCLAAGNTMVYKPSEFTPLHSTLLAEIYAEAGVPPGVFNVVQGGGDVGAYLTKHPDVAKVSFTGQVSTGQKVAGSAAGGMKYVTMELGGKSACIILPDADIDQAVDGAMMANFFSTGQVCTNGTRVFVPQSIKAAFEKKLLDKVKHIRAGDVSDPNTNFGPLVSKPHYEKVLSYIKHGIQVDKATLLCGGPEKPAWLSSHKNKDYQNGYWVTPTIFTDCTDNMRIVQEEIFGPVMSLLSYADNDIASLIARANNTDVGLAAGVFTKNLNLAHQVIGQLEAGITWINTWGESPAEMSVGGWKLSGVGVENGRKGLEAWVKNKSTLVDMGGEVPTVFAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CLG5</accession>
    <name>A0A177CLG5_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_575886</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038740.1">
        <property type="nucleotide sequence ID" value="XM_018186730.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CLG5"/>
    <dbReference type="GeneID" id="28770216"/>
    <dbReference type="InParanoid" id="A0A177CLG5"/>
    <dbReference type="OrthoDB" id="62952at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38790">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38790:SF9">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG08375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="333" mass="38760" checksum="B4FD8C025E2E1F13" modified="2016-09-07" version="1">MSMMALRRNPYRKCKFEEVLDTAVVGQESKKRKRSCAVEVPAMRVPAKIQRVAHNKPPCVPFVSTAQKSPFAFFDLPREVRDHVLSYLVVRRGRQLPLLEAKGILREQKKRATVLRNREKQNIKRAQTGRPPVAHRDAPTESIVCLDAMRASKTLYHEAKDCFYRCNHFAVSLDSFPATTMEIPAGWDCSRIKRLQLELQLKDSPRMNSYIDWTSFFAKFPSLVHLRIIPSFHPRYYEWARPELDDWNTAHFVFRAFFRELLASIPEDLSCKLGQSMDPQEDMQLEGKAPVSNKVLWDMYTDLGPRSGIRRHAAQMFDLVQRPSHVNEHWAHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CLL9</accession>
    <name>A0A177CLL9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1239629</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038809.1">
        <property type="nucleotide sequence ID" value="XM_018183983.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CLL9"/>
    <dbReference type="GeneID" id="28767469"/>
    <dbReference type="InParanoid" id="A0A177CLL9"/>
    <dbReference type="OrthoDB" id="3469466at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG08444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="231" mass="26287" checksum="7D5E84B02D193DED" modified="2016-09-07" version="1">MYRSAPISFDTRSRSAARSHAARVGWQRSSKAAKIQERQRMLKDFLPESAWEPRWNNQEAVNRQPNQTSTQRNINAGSINDAIRVIDVSLAYGKIFPSHGAISLPMLDETTDSTAFHVAQFLGTFIWPTVGGHIAAYQWFQDFCTSRVLFHSQSAASATYRDLMAGKPSISMTRRNFQHKLEAIREIRSSLTRWHMVSKPEREQVIFAILILASHEVKEKDFLETTSPFSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CLR7</accession>
    <name>A0A177CLR7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Mitochondrial import inner membrane translocase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CC84DRAFT_1195791</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Mitochondrial intermembrane chaperone that participates in the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="function">
        <text evidence="15">Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Heterohexamer; composed of 3 copies of TIM9 and 3 copies of TIM10, named soluble 70 kDa complex. Associates directly with the TIM22 complex, whose core is composed of TIM22 and TIM54. Interacts with the transmembrane regions of multi-pass transmembrane proteins in transit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Mitochondrion inner membrane</location>
            <topology evidence="1 15">Peripheral membrane protein</topology>
            <orientation evidence="1 15">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="15">The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the small Tim family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG07727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038092.1">
        <property type="nucleotide sequence ID" value="XM_018181420.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CLR7"/>
    <dbReference type="FunCoup" id="A0A177CLR7">
        <property type="interactions" value="656"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CLR7"/>
    <dbReference type="GeneID" id="28764906"/>
    <dbReference type="InParanoid" id="A0A177CLR7"/>
    <dbReference type="OrthoDB" id="274922at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042719">
        <property type="term" value="C:mitochondrial intermembrane space chaperone complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042721">
        <property type="term" value="C:TIM22 mitochondrial import inner membrane insertion complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140318">
        <property type="term" value="F:protein transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045039">
        <property type="term" value="P:protein insertion into mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.810:FF:000002">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit tim10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.810">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit tim13 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004217">
        <property type="entry name" value="Tim10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035427">
        <property type="entry name" value="Tim10-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11038">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11038:SF16">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02953">
        <property type="entry name" value="zf-Tim10_DDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144122">
        <property type="entry name" value="Tim10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 15" id="KW-0143">Chaperone</keyword>
    <keyword evidence="11 15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 15" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 15" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7 15" id="KW-0653">Protein transport</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 15" id="KW-0811">Translocation</keyword>
    <keyword evidence="3 15" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Tim10-like" evidence="16">
        <location>
            <begin position="17"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00055537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00065568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU367043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="OAG07727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="96" mass="10469" checksum="000FD05B8D717B3C" modified="2016-09-07" version="1">MSFLFGRQPQLSSEQKIAQAEAEIDMVSDMYARLVQSCSKKCLDTSYREADLNKGESVCLDRCVAKFFEVNVKVSEKMQGEAQGKAAGGAMFGGGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CM74</accession>
    <name>A0A177CM74_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Autophagy-related protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CC84DRAFT_1061089</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Preautophagosomal structure membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG07960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038325.1">
        <property type="nucleotide sequence ID" value="XM_018173584.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CM74"/>
    <dbReference type="STRING" id="1460663.A0A177CM74"/>
    <dbReference type="GeneID" id="28757070"/>
    <dbReference type="InParanoid" id="A0A177CM74"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005776">
        <property type="term" value="C:autophagosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010506">
        <property type="term" value="P:regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042594">
        <property type="term" value="P:response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061709">
        <property type="term" value="P:reticulophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045269">
        <property type="entry name" value="Atg1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24348:SF22">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24348">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE UNC-51-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0072">Autophagy</keyword>
    <keyword evidence="6 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 12 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 13" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="19"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OAG07960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="260" mass="29354" checksum="6925EB646561FACA" modified="2016-09-07" version="1" fragment="single">ISIGKGAHLEIQDKEVLPYKLVRNLGHGASASVELVLDQNTKKVYARKVFKNVYGRTLKDVKQHFRNEIRIMRRLSSGHHVVNLYATYLAGRELALILDPAADGGDLAEFMQGYDDLQQELSDSRKHSGTVHSNGSDLHQIVQLERRRIEMLTTLKRAFGCLASGLEFIHKQTIRHKDIKPQNILIHQGNVLYTDFGFSLDHSTRGRSTTTGRPNAFTRRYCAPEVADHDRRNSTSDIFSLGCVYAEITATLYPGLIPER</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CMA6</accession>
    <name>A0A177CMA6_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="4">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">CC84DRAFT_1114002</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Required for the control of telomere length and genome stability.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Associates with DNA double-strand breaks.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="14">Vacuole membrane</location>
            <topology evidence="14">Peripheral membrane protein</topology>
            <orientation evidence="14">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PI3/PI4-kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4"/>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG07897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038262.1">
        <property type="nucleotide sequence ID" value="XM_018175382.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A177CMA6">
        <property type="interactions" value="1072"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CMA6"/>
    <dbReference type="GeneID" id="28758868"/>
    <dbReference type="InParanoid" id="A0A177CMA6"/>
    <dbReference type="OrthoDB" id="381190at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031931">
        <property type="term" value="C:TORC1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031932">
        <property type="term" value="C:TORC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006995">
        <property type="term" value="P:cellular response to nitrogen starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016242">
        <property type="term" value="P:negative regulation of macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905356">
        <property type="term" value="P:regulation of snRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038202">
        <property type="term" value="P:TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05169">
        <property type="entry name" value="PIKKc_TOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1070.11:FF:000020">
        <property type="entry name" value="Serine/threonine-protein kinase TOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.150:FF:000001">
        <property type="entry name" value="Serine/threonine-protein kinase TOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000371">
        <property type="entry name" value="Serine/threonine-protein kinase TOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000582">
        <property type="entry name" value="Serine/threonine-protein kinase TOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1010.10:FF:000006">
        <property type="entry name" value="Serine/threonine-protein kinase TOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.150">
        <property type="entry name" value="FKBP12-rapamycin binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1010.10">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050517">
        <property type="entry name" value="DDR_Repair_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003152">
        <property type="entry name" value="FATC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009076">
        <property type="entry name" value="FRB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036738">
        <property type="entry name" value="FRB_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057564">
        <property type="entry name" value="HEAT_ATR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024585">
        <property type="entry name" value="mTOR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003151">
        <property type="entry name" value="PIK-rel_kinase_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014009">
        <property type="entry name" value="PIK_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026683">
        <property type="entry name" value="TOR_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139">
        <property type="entry name" value="ATAXIA TELANGIECTASIA MUTATED ATM -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139:SF9">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE MTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02259">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02260">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08771">
        <property type="entry name" value="FRB_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23593">
        <property type="entry name" value="HEAT_ATR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13513">
        <property type="entry name" value="HEAT_EZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11865">
        <property type="entry name" value="mTOR_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01346">
        <property type="entry name" value="DUF3385"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01343">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01345">
        <property type="entry name" value="Rapamycin_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47212">
        <property type="entry name" value="FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51189">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51190">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00915">
        <property type="entry name" value="PI3_4_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00916">
        <property type="entry name" value="PI3_4_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0926">Vacuole</keyword>
    <feature type="repeat" description="HEAT" evidence="17">
        <location>
            <begin position="707"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="domain" description="FAT" evidence="20">
        <location>
            <begin position="1246"/>
            <end position="1847"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="19">
        <location>
            <begin position="2021"/>
            <end position="2341"/>
        </location>
    </feature>
    <feature type="domain" description="FATC" evidence="21">
        <location>
            <begin position="2391"/>
            <end position="2423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="2301"/>
            <end position="2336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="2323"/>
            <end position="2336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00025079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00029427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="OAG07897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="2423" mass="273557" checksum="408698BF78E259A6" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CMN4</accession>
    <name>A0A177CMN4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Catalase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1257398</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038921.1">
        <property type="nucleotide sequence ID" value="XM_018184728.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CMN4"/>
    <dbReference type="GeneID" id="28768214"/>
    <dbReference type="InParanoid" id="A0A177CMN4"/>
    <dbReference type="OrthoDB" id="5220117at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG08556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="228" mass="25956" checksum="04635A098909D1C5" modified="2016-09-07" version="1">MDDEWQTTALGSRHMHNRVQNKSSRKYRPFDVHKTFGSYSCKWAAGKRRDDNHDDENDITLELYRLSPHGEGVLGEIRFPRALDAAVVLSGSRASLDKTVRGIEVDSDEEDDEETQSEEKNESGSDERDAEDPVDDREFEEEPARFRKFEKNSFREPKFWIRWNGMTEGAEVVTSDLGYVVFSGNECRNFKGTITCEALGWKDAAISGRKVSGRAPSDVPINWNGKTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CMT1</accession>
    <name>A0A177CMT1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">FAD binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CC84DRAFT_1115624</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039210.1">
        <property type="nucleotide sequence ID" value="XM_018175431.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CMT1"/>
    <dbReference type="STRING" id="1460663.A0A177CMT1"/>
    <dbReference type="GeneID" id="28758917"/>
    <dbReference type="InParanoid" id="A0A177CMT1"/>
    <dbReference type="OrthoDB" id="9983560at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050432">
        <property type="entry name" value="FAD-linked_Oxidoreductases_BP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13878:SF91">
        <property type="entry name" value="FAD BINDING DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G12070)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13878">
        <property type="entry name" value="GULONOLACTONE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008058486" evidence="3">
        <location>
            <begin position="17"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="4">
        <location>
            <begin position="194"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAG08845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="659" mass="71306" checksum="114393DB64F192D3" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CMU7</accession>
    <name>A0A177CMU7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1162091</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038452.1">
        <property type="nucleotide sequence ID" value="XM_018177905.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CMU7"/>
    <dbReference type="GeneID" id="28761391"/>
    <dbReference type="InParanoid" id="A0A177CMU7"/>
    <dbReference type="OrthoDB" id="187836at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG08087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="54" mass="6329" checksum="C7156B2BE9D98A4C" modified="2016-09-07" version="1">MSREFTVKYYQVIKRRVREVKGGLHMRLYSCVLSTSQELQSSNTPMSGKRLVCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CN10</accession>
    <name>A0A177CN10_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Kinesin light chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1162318</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038717.1">
        <property type="nucleotide sequence ID" value="XM_018177960.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CN10"/>
    <dbReference type="STRING" id="1460663.A0A177CN10"/>
    <dbReference type="GeneID" id="28761446"/>
    <dbReference type="InParanoid" id="A0A177CN10"/>
    <dbReference type="OrthoDB" id="5986190at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13374">
        <property type="entry name" value="TPR_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG08352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="85" mass="10017" checksum="EF1CCF6998D0D3B2" modified="2016-09-07" version="1">METRKTKLGADHPDTLTSMNNLAFTWKSLGWTVKAIYLMQQCVQRREQVLGASYPHYLSSLLILEQWEEEQADVELLNRFKDMRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CN78</accession>
    <name>A0A177CN78_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Hypervirulence associated protein TUDOR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1162333</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038723.1">
        <property type="nucleotide sequence ID" value="XM_018177963.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CN78"/>
    <dbReference type="STRING" id="1460663.A0A177CN78"/>
    <dbReference type="GeneID" id="28761449"/>
    <dbReference type="InParanoid" id="A0A177CN78"/>
    <dbReference type="OrthoDB" id="2131339at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021331">
        <property type="entry name" value="Hva1_TUDOR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11160">
        <property type="entry name" value="Hva1_TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hypervirulence associated protein TUDOR" evidence="2">
        <location>
            <begin position="9"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG08358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="265" mass="28573" checksum="0FAC4E103D5B0C3C" modified="2016-09-07" version="1">MADTQIQEGDKVSWQWGSGQPGGEVAEVKTQGEIAIESKKGNTIKKNADPENPAVHIERPGNDVVKRASELEVEEKANGNSEQTNGDSKSEGKQPEPGKADKESESDNKADEEAAEPEKKDVEMKDAPADDGGANKQADQEDSEKQNGAAEDAEASKGDADKEEPKEEAQEEKSASKNEKAEEDLQTGDKRKAEESAAETNGAEGDEEHASKKAKADEEKTEDKKKPGRPKGDAKKEKKEPAKKKEPKKAATADGQPRRSGRNRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CNE2</accession>
    <name>A0A177CNE2_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">FR47-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1142240</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG09055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039420.1">
        <property type="nucleotide sequence ID" value="XM_018176355.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CNE2"/>
    <dbReference type="STRING" id="1460663.A0A177CNE2"/>
    <dbReference type="GeneID" id="28759841"/>
    <dbReference type="InParanoid" id="A0A177CNE2"/>
    <dbReference type="OrthoDB" id="61870at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053225">
        <property type="entry name" value="Acyl-CoA_N-acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20958">
        <property type="entry name" value="GLYCINE N-ACYLTRANSFERASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20958:SF6">
        <property type="entry name" value="GLYCINE N-ACYLTRANSFERASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG09055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="347" mass="38507" checksum="CC05637CF3DD80E1" modified="2016-09-07" version="1">MQVYEHPASSPPLQAALKSTLPHSMSIFYRTKHPNRTADAHILATFPISTTDSISRCWATAYLDRSMRPETELWIFTTGEMPGHYASPDKEKQGFCTECKKAVLSLIDYMGSLPIPPIHPWNEPAIELARQHEKEHPQTGPDAAYPPGPGLYMRHLLIPTIVTLGACHQEVVQLLAEAGILCKEFPGHEAYLNKFWFKVSDLPHTRDLPEELRWGEMREQDIAIVQARTSIPRTARTLLSLKSVGVFEIATDKPVAWTFLGLDGSLTTLHTEPKWRGKGIAKAVAVKIFKEHAPGLAVDDEQNAWAHADVYVGNVQSESVCRSLGGKPSVKILWVRVDIGKGGRLGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CNU8</accession>
    <name>A0A177CNU8_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RFX-type winged-helix domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_430496</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG09184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039549.1">
        <property type="nucleotide sequence ID" value="XM_018186221.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CNU8"/>
    <dbReference type="STRING" id="1460663.A0A177CNU8"/>
    <dbReference type="GeneID" id="28769707"/>
    <dbReference type="InParanoid" id="A0A177CNU8"/>
    <dbReference type="OrthoDB" id="10056949at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000119">
        <property type="entry name" value="DNA damage and replication checkpoint protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003150">
        <property type="entry name" value="DNA-bd_RFX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039779">
        <property type="entry name" value="RFX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057321">
        <property type="entry name" value="RFX1-4/6/8-like_BCD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12619">
        <property type="entry name" value="RFX TRANSCRIPTION FACTOR FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12619:SF5">
        <property type="entry name" value="TRANSCRIPTION FACTOR RFX4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25340">
        <property type="entry name" value="BCD_RFX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02257">
        <property type="entry name" value="RFX_DNA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51526">
        <property type="entry name" value="RFX_DBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RFX-type winged-helix" evidence="3">
        <location>
            <begin position="202"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="274"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="693"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="8"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="302"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="703"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="738"/>
            <end position="748"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAG09184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="797" mass="88655" checksum="3BF5BED1A3540C21" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CPD2</accession>
    <name>A0A177CPD2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Phytanoyl-CoA dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_1204049</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PhyH family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039143.1">
        <property type="nucleotide sequence ID" value="XM_018181877.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CPD2"/>
    <dbReference type="FunCoup" id="A0A177CPD2">
        <property type="interactions" value="14"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CPD2"/>
    <dbReference type="GeneID" id="28765363"/>
    <dbReference type="InParanoid" id="A0A177CPD2"/>
    <dbReference type="OrthoDB" id="445007at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20883">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE DOMAIN CONTAINING 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20883:SF45">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAG08778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="310" mass="35058" checksum="FDDAD5086A0B220C" modified="2016-09-07" version="1">MPSTINELPSGVQSVAADAPFDYIIRLLKRDGGVFIKKFVSEEDVDQAYSECRDRIDNDMEWEGDFFPKETQRAPGLIGLSPTYTKTQLMHPLYRAVCDHFLTTRSMFWWGNERKESVSKPYVHSAVAMRIGPGGKAQPLHRDDYIAHNVHTEVSEWDDARDMNRESAVGCFVAGCRVTPENGGTNFIPGSHLWGNDRKEPPDVSMCIQADMEKGDAFFMLASAFHGGGANSTKDEQRLVFGTFVTRGYLRQEENQFLAVPPEVARQYPRDVLEYLGYSISDPACGTVDQLDPIYALYPEWKKDAKYKDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2023-06-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CPQ9</accession>
    <name>A0A177CPQ9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_432279</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG09211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039576.1">
        <property type="nucleotide sequence ID" value="XM_018186227.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CPQ9"/>
    <dbReference type="GeneID" id="28769713"/>
    <dbReference type="InParanoid" id="A0A177CPQ9"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG09211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="178" mass="20421" checksum="8CC580B5636ED66A" modified="2016-09-07" version="1">MRGAACRFPASTMRWLLVQVDCRGRFRAQRCVRLGGSFRDCGARVARCESRCEGYRWCLPAMNAPSPALAWDRGYVINTVWLFQREHKIHLVTNAFHKDILCLRTLLPSRYAFLRCSNCISALHRNQAPSPRSVLAVGRNKALADFIHACDITTPLLYLQHFLRTTRSISIITLDKWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CPY4</accession>
    <name>A0A177CPY4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Nucleolar GTP-binding protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_1193179</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG09291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039656.1">
        <property type="nucleotide sequence ID" value="XM_018181279.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CPY4"/>
    <dbReference type="FunCoup" id="A0A177CPY4">
        <property type="interactions" value="1207"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CPY4"/>
    <dbReference type="GeneID" id="28764765"/>
    <dbReference type="InParanoid" id="A0A177CPY4"/>
    <dbReference type="OrthoDB" id="61815at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000054">
        <property type="term" value="P:ribosomal subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01857">
        <property type="entry name" value="HSR1_MMR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001558">
        <property type="entry name" value="Ribosome biogenesis GTPase Lsg1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030378">
        <property type="entry name" value="G_CP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043358">
        <property type="entry name" value="GNL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45709:SF2">
        <property type="entry name" value="LARGE SUBUNIT GTPASE 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45709">
        <property type="entry name" value="LARGE SUBUNIT GTPASE 1 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51721">
        <property type="entry name" value="G_CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CP-type G" evidence="7">
        <location>
            <begin position="177"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="22"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="115"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="263"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="647"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="22"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="270"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="302"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="655"/>
            <end position="668"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAG09291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="674" mass="76207" checksum="7662A7B7A218CD86" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CR06</accession>
    <name>A0A177CR06_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6699 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1160975</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG09953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040318.1">
        <property type="nucleotide sequence ID" value="XM_018177627.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CR06"/>
    <dbReference type="GeneID" id="28761113"/>
    <dbReference type="InParanoid" id="A0A177CR06"/>
    <dbReference type="OrthoDB" id="5363135at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046522">
        <property type="entry name" value="DUF6699"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20415">
        <property type="entry name" value="DUF6699"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6699" evidence="2">
        <location>
            <begin position="59"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG09953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="168" mass="18863" checksum="CBCDB0E9DEC2E26F" modified="2016-09-07" version="1">MAADTADTLQKVDSLVDEGKDKAPAKRRQSSLRADVFNMADLEKEGKKIEIAPETQKLNWKINKSPTTVEDSEVLKKPLTTPLVRKIDLHFPLGLEVTARNLKGVTIKDALDAIYKQFRKKADDEIGDAPYLAGFEWDPEECYTRFIVHQKKEGAPPPSKKKKKGGDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CR11</accession>
    <name>A0A177CR11_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Acetyl-CoA synthetase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CC84DRAFT_1053800</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG09382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039747.1">
        <property type="nucleotide sequence ID" value="XM_018173509.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CR11"/>
    <dbReference type="STRING" id="1460663.A0A177CR11"/>
    <dbReference type="GeneID" id="28756995"/>
    <dbReference type="InParanoid" id="A0A177CR11"/>
    <dbReference type="OrthoDB" id="429813at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051414">
        <property type="entry name" value="Adenylate-forming_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43439:SF2">
        <property type="entry name" value="ENZYME, PUTATIVE (JCVI)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43439">
        <property type="entry name" value="PHENYLACETATE-COENZYME A LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="4">
        <location>
            <begin position="10"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="388"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="393"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAG09382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="408" mass="45691" checksum="327438383798ED73" modified="2016-09-07" version="1" fragment="single">GNRLMPVMVDEVAAETPDRVCFSIPRSTDLKAGFHDITFQTFANAINKTASFIEREIGRSSMFETVMYMGIQDVRYFIVLFALMKTGHKVLFSSHRNSVAGHTDLVKQTDCGIIMYTNGLSCAGIIEASRMETLCMPELDYLFDDSVHTDPYPYTKTFEQAKHHPCMVTHTTNSTGMPKPVIWTHWLLATTDAQRLVPDFDGRPTVWNKVFDSSERCYSGVPICDSAGIVTALVEVLLNGCTVVLGPPNNPTANTFEQVVTYGRVDAASLLPRTLEEIASSQTGLALLSRLKYVAYAAGSLSPRAGEILSRYTHLYSLMVSTETGSIIQHATDREDWQYMCINPKYNGIEWRPRGSLYELVFKKSNDLADVQGIFKTSLRSQECSMGDLYSKHPTKPHHWKHEGRTDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CR49</accession>
    <name>A0A177CR49_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glycoside hydrolase family 125 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_449394</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG09691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040056.1">
        <property type="nucleotide sequence ID" value="XM_018186313.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CR49"/>
    <dbReference type="STRING" id="1460663.A0A177CR49"/>
    <dbReference type="GeneID" id="28769799"/>
    <dbReference type="InParanoid" id="A0A177CR49"/>
    <dbReference type="OrthoDB" id="7771656at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008313">
        <property type="entry name" value="GH125"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31047">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 157 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31047:SF0">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 157 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06824">
        <property type="entry name" value="Glyco_hydro_125"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028846">
        <property type="entry name" value="UCP028846"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01149">
        <property type="entry name" value="DUF1237"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008058582" description="Glycoside hydrolase family 125 protein" evidence="1">
        <location>
            <begin position="27"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG09691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="547" mass="61118" checksum="268857AA09594E2F" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CR54</accession>
    <name>A0A177CR54_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Glucanase</fullName>
            <ecNumber evidence="10">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CC84DRAFT_1136751</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="10">Belongs to the glycosyl hydrolase family 6.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="10"/>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG09257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039622.1">
        <property type="nucleotide sequence ID" value="XM_018176112.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CR54"/>
    <dbReference type="STRING" id="1460663.A0A177CR54"/>
    <dbReference type="GeneID" id="28759598"/>
    <dbReference type="InParanoid" id="A0A177CR54"/>
    <dbReference type="OrthoDB" id="64893at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.40">
        <property type="entry name" value="1, 4-beta cellobiohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016288">
        <property type="entry name" value="Beta_cellobiohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036434">
        <property type="entry name" value="Beta_cellobiohydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001524">
        <property type="entry name" value="Glyco_hydro_6_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34876">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34876:SF2">
        <property type="entry name" value="GLUCANASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01341">
        <property type="entry name" value="Glyco_hydro_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001100">
        <property type="entry name" value="Beta_cellobiohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00733">
        <property type="entry name" value="GLHYDRLASE6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51989">
        <property type="entry name" value="Glycosyl hydrolases family 6, cellulases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00655">
        <property type="entry name" value="GLYCOSYL_HYDROL_F6_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00656">
        <property type="entry name" value="GLYCOSYL_HYDROL_F6_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2 10" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="4 10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1 10 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 10" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007948990" description="Glucanase" evidence="10">
        <location>
            <begin position="19"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="107"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6 9">
        <location>
            <position position="152"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="334"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="300"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="328"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="332"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001100-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR001100-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OAG09257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="379" mass="40104" checksum="D367E5004151420A" modified="2016-09-07" version="1">MKGLYSAVLASAIAGAFAAPSPVEQGPVTARAAMAACATPVTLSGNPFKSRSIYANKEYSKEVIAAAASMTDSALAAKASKVAQDNLKDVPCDQLAAFVIYDLPGRDCAAKASNGELAAGDITTYKSEYIDPIVDIFKKYPNTAIALVIEPDSLPNLVTNADKQACKDSASGYREGVAYALKKLNLPNIAMYIDAGHGGWLGWNDNLKPGAKELATVFKNAGSPKQVRGISTNVAGWNAWDLSPGEFSKATDAQWNKCQNEKTYVETFGPLLKDAGMPGQAIVDTGRNAVTGLRKEWGDWCNVKGAGFGVRPTGTTGSSYADAFVWVKPGGESDGTSDTSATRYDSFCGKDDAFKPAPEAGQWNQAYFEDLIKNAKPSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CS41</accession>
    <name>A0A177CS41_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF7730 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_1161305</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040710.1">
        <property type="nucleotide sequence ID" value="XM_018177698.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CS41"/>
    <dbReference type="STRING" id="1460663.A0A177CS41"/>
    <dbReference type="GeneID" id="28761184"/>
    <dbReference type="InParanoid" id="A0A177CS41"/>
    <dbReference type="OrthoDB" id="3801532at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056632">
        <property type="entry name" value="DUF7730"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38790">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24864">
        <property type="entry name" value="DUF7730"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7730" evidence="3">
        <location>
            <begin position="88"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAG10345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="375" mass="43764" checksum="67C19B2FA5A91A49" modified="2016-09-07" version="1">MRAAGKACLYTLFCPFFCCYCCLMIPQAITPKCGNWRRQKHREKHSKMVILQIEKRERQHKRRNSLTSEPSTARKLGNYLRRRERWCDQESSTFFSKLPTEIRMHIYALVLNGKDHIYIDQNRWNERFEINCRLLDKHAHLFVDLDRATTKRKEDGNLDTIGKGRPQATDTEDLERKESRNTETTEAADGRPQVHNPSTTKGTQDRNGREPRRTKSLLPLLLTCRRVYAEAIPLLYSGNTFVTCVGHNLHYFPRSIPEVHRDRITSLVIYSPIGSGISWESTERTLLSFKNLKSCRIVIVEEEALLWPRSREHLRPESLNDVQSLYGIHCLPILRGIEETCLWDKITLTIDFWSAGMRIRVGGEDRRLQAREKLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CS89</accession>
    <name>A0A177CS89_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF8004 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1161352</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040760.1">
        <property type="nucleotide sequence ID" value="XM_018177708.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CS89"/>
    <dbReference type="STRING" id="1460663.A0A177CS89"/>
    <dbReference type="GeneID" id="28761194"/>
    <dbReference type="InParanoid" id="A0A177CS89"/>
    <dbReference type="OrthoDB" id="5302380at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058317">
        <property type="entry name" value="DUF8004"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39601">
        <property type="entry name" value="CHORIOGENIN HMINOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39601:SF2">
        <property type="entry name" value="CHORIOGENIN HMINOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26013">
        <property type="entry name" value="DUF8004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF8004" evidence="2">
        <location>
            <begin position="405"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="244"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="302"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="868"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="44"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="943"/>
            <end position="953"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG10395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="953" mass="107757" checksum="8989709387B260A0" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CTJ3</accession>
    <name>A0A177CTJ3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">mRNA decay factor PAT1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CC84DRAFT_1256105</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">P-body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PAT1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040597.1">
        <property type="nucleotide sequence ID" value="XM_018184597.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CTJ3"/>
    <dbReference type="FunCoup" id="A0A177CTJ3">
        <property type="interactions" value="200"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CTJ3"/>
    <dbReference type="GeneID" id="28768083"/>
    <dbReference type="InParanoid" id="A0A177CTJ3"/>
    <dbReference type="OrthoDB" id="74835at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000290">
        <property type="term" value="P:deadenylation-dependent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033962">
        <property type="term" value="P:P-body assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039900">
        <property type="entry name" value="Pat1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019167">
        <property type="entry name" value="PAT1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21551:SF0">
        <property type="entry name" value="PROTEIN ASSOCIATED WITH TOPO II RELATED-1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21551">
        <property type="entry name" value="TOPOISOMERASE II-ASSOCIATED PROTEIN PAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09770">
        <property type="entry name" value="PAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="mRNA decay factor PAT1" evidence="8">
        <location>
            <begin position="1"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="108"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="156"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="194"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="525"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="108"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="158"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="221"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="293"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="539"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF09770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAG10232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="852" mass="95220" checksum="2C6E4BB5EE1274C4" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2023-06-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CUI6</accession>
    <name>A0A177CUI6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1170156</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG11215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041580.1">
        <property type="nucleotide sequence ID" value="XM_018179837.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CUI6"/>
    <dbReference type="GeneID" id="28763323"/>
    <dbReference type="InParanoid" id="A0A177CUI6"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG11215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="159" mass="17184" checksum="590B83905B936F69" modified="2016-09-07" version="1">MPVTPGGVAGNKQSMLAASQWAPEDSFHFAPGTIQTIVIAARTAEWPAALPEGGAPCMAFPSLKSVGTAVHDAFIFPWRIPAMDSALGWVAGSDSVNRLQSSIHPSWSGHTANGEGMSTRSVFIKDSAYRSQKRQKKEKKTCQYRNVRPRTGPESVKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CUR2</accession>
    <name>A0A177CUR2_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Nab2-like CCCH zinc finger domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CC84DRAFT_1079193</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ZC3H14 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG11295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041660.1">
        <property type="nucleotide sequence ID" value="XM_018173831.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CUR2"/>
    <dbReference type="STRING" id="1460663.A0A177CUR2"/>
    <dbReference type="GeneID" id="28757317"/>
    <dbReference type="InParanoid" id="A0A177CUR2"/>
    <dbReference type="OrthoDB" id="438553at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008143">
        <property type="term" value="F:poly(A) binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043488">
        <property type="term" value="P:regulation of mRNA stability"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.340.40:FF:000001">
        <property type="entry name" value="Nuclear polyadenylated RNA-binding protein nab2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.40">
        <property type="entry name" value="Nuclear abundant poly(A) RNA-bind protein 2, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055046">
        <property type="entry name" value="Nab2-like_Znf-CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040366">
        <property type="entry name" value="Nab2/ZC3H14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043094">
        <property type="entry name" value="Nab2/ZC3H14_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14738">
        <property type="entry name" value="ZINC FINGER CCCH DOMAIN-CONTAINING PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14738:SF29">
        <property type="entry name" value="ZINC FINGER CCCH DOMAIN-CONTAINING PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22683">
        <property type="entry name" value="Nab2-like_zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14608">
        <property type="entry name" value="zf-CCCH_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nab2-like CCCH zinc finger" evidence="9">
        <location>
            <begin position="450"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="107"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="285"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="153"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="295"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="331"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF22683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAG11295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="524" mass="56668" checksum="D6E2242EB8F397D5" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CUW1</accession>
    <name>A0A177CUW1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Endoglucanase EG-II</fullName>
            <ecNumber evidence="3">3.2.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CC84DRAFT_1213887</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Endoglucanase (EG) that cleaves the internal beta-1,4-glucosidic bonds in cellulose. The degradation of cellulose involves an interplay between different cellulolytic enzymes. Hydrolysis starts with EGs, which cut internal glycosidic linkages to reduce the polymerization degree of the substrate and creates new chain ends for exocellobiohydrolases (CBHs). The CBH release the disaccharide cellobiose from the non-reducing end of the cellulose polymer chain. Finally, beta-1,4-glucosidases hydrolyze the cellobiose and other short cello-oligosaccharides into glucose units.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endohydrolysis of (1-&gt;4)-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans.</text>
            <dbReference type="EC" id="3.2.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.4" evidence="3"/>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040942.1">
        <property type="nucleotide sequence ID" value="XM_018182581.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CUW1"/>
    <dbReference type="STRING" id="1460663.A0A177CUW1"/>
    <dbReference type="GeneID" id="28766067"/>
    <dbReference type="InParanoid" id="A0A177CUW1"/>
    <dbReference type="OrthoDB" id="5823761at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008810">
        <property type="term" value="F:cellulase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030248">
        <property type="term" value="F:cellulose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000124">
        <property type="entry name" value="Exported cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000254">
        <property type="entry name" value="CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035971">
        <property type="entry name" value="CBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018087">
        <property type="entry name" value="Glyco_hydro_5_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34142:SF5">
        <property type="entry name" value="CBM1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34142">
        <property type="entry name" value="ENDO-BETA-1,4-GLUCANASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00734">
        <property type="entry name" value="CBM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00236">
        <property type="entry name" value="fCBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57180">
        <property type="entry name" value="Cellulose-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00562">
        <property type="entry name" value="CBM1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51164">
        <property type="entry name" value="CBM1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00659">
        <property type="entry name" value="GLYCOSYL_HYDROL_F5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="9 13" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="8" id="KW-0873">Pyrrolidone carboxylic acid</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 14" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008058613" description="Endoglucanase EG-II" evidence="14">
        <location>
            <begin position="22"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="domain" description="CBM1" evidence="15">
        <location>
            <begin position="21"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00059691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00074271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OAG10577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="440" mass="45094" checksum="BADE3DBD6D884AAA" modified="2016-09-07" version="1">MARYSFAFTALAATGAAAAAAQGTAYAQCGGQGWTGATTCVSGYHCQFQNDWYSQCIPGAASAAVSSAAAKTTLVTLVRTSAAAKTSSAAKTSVAKTTAVVAKTTAVVAAASSTVSTAKAAAATSSSGKTQYAGVNIAGFDFGCYTDGSCGGSYSDPGANGIAQMKHFATDDKLNVFRLPIGWQHLLNNVLGGSIDATVGAAYDKLVQGCLATGALCVIDLHNYARWNGAIVGQGGPTDAQFADVWSKLATKYASQKNIAFGLMNEPHDLTMSTWATSVQAAVTAIRKAGATSQMILLPGTDYTSAGTFVANSGPALLKVTDSDGTTSKLIFDVHRYLDSDNSGTNAECVTDHVADTFVPLATWLRTNKRQAILSEVGGGNTASCQTDVCAAIASLNQNSDVYLGYIGWSAGAFDTSYVLSLTPNGSADQALLTKCFSRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CVX3</accession>
    <name>A0A177CVX3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_44056</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG11714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042079.1">
        <property type="nucleotide sequence ID" value="XM_018186289.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CVX3"/>
    <dbReference type="GeneID" id="28769775"/>
    <dbReference type="InParanoid" id="A0A177CVX3"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG11714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="117" mass="13002" checksum="092CEDF295F8639A" modified="2016-09-07" version="1">MTETKDDGLLRIPCCCSFAFAFAFHYPVLLLNFCSAFVLRCILSTAARYGALSISIYLARPLHSREVLSAFSEQGFCIIMVRLRHFWCDIVHGMAMSLVSVVACSAPLHTVNTTAYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CW17</accession>
    <name>A0A177CW17_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RED-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CC84DRAFT_2029</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG11228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041593.1">
        <property type="nucleotide sequence ID" value="XM_018185582.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CW17"/>
    <dbReference type="STRING" id="1460663.A0A177CW17"/>
    <dbReference type="GeneID" id="28769068"/>
    <dbReference type="InParanoid" id="A0A177CW17"/>
    <dbReference type="OrthoDB" id="3366823at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039896">
        <property type="entry name" value="Red-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012916">
        <property type="entry name" value="RED_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12765">
        <property type="entry name" value="RED PROTEIN IK FACTOR CYTOKINE IK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07808">
        <property type="entry name" value="RED_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RED-like N-terminal" evidence="4">
        <location>
            <begin position="50"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="193"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="382"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="211"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="260"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="279"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="428"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="454"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAG11228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="463" mass="51542" checksum="D76B1932E5A731CF" modified="2016-09-07" version="1">MQGQTLQRRSLERIADEDDEAAQRIKNLEEAMKLGQIDRDMFEKLVQDITGGDIAATHLVKGLDRKLLERVRKGEDVFEQPAPEEEVPEQAADVEDEFDELAERDIGSIVREKGEKKGEVAPPKPVAGVKRTRADILAELRRQREVAAAAAATEYEKRYPSLGKGFRKVSEPGETSRIEIDKQGREILIITDAQGKEKRKVRKQKAQEPLPEVRHDLDDENKPINTHHLPPAKEEQEGSEEDDIFEGVGSNYNPLAALDSEVDSSEEEGEAQDTAALFENEKTIPKEQDANDDDPDRHSTKPSVSACDPAPKRNYFASSKILTSSESIQPSESSTADATVRAALQKVRTLDPNSSLINDADSEEFRLKARLAKLSASDRDMEDMDMGFGASRFDDAEDMEREGEKVKFSEWKGIGGAEDEDGEDGPRSGKKRKRGPKKKKGDKNSATDVLMAMEKQKEKKTLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2023-06-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CWK5</accession>
    <name>A0A177CWK5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1159336</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG11925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042290.1">
        <property type="nucleotide sequence ID" value="XM_018177204.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CWK5"/>
    <dbReference type="GeneID" id="28760690"/>
    <dbReference type="InParanoid" id="A0A177CWK5"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG11925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="157" mass="17887" checksum="01341EC4670C1194" modified="2016-09-07" version="1">MYYIMRWSQVQPCIWSRRGQTRTSYNRNRFEMMLEAPGNSRNTSRYGLLFHLIICAVRKIRYRCECAMDGVSATIARVRAFRSLDVSNTSASLALHQQHHPVHVNSSTMHYSAHNIRVLSIDLPPLGICASETPSIYRTHIVADDDAWKGMQSATAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CXC2</accession>
    <name>A0A177CXC2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1253934</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG11477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041842.1">
        <property type="nucleotide sequence ID" value="XM_018184417.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CXC2"/>
    <dbReference type="GeneID" id="28767903"/>
    <dbReference type="InParanoid" id="A0A177CXC2"/>
    <dbReference type="OrthoDB" id="4868352at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="350"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="363"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="388"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="423"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="468"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="535"/>
            <end position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG11477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="602" mass="68837" checksum="205F64257FCD51C4" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CXK4</accession>
    <name>A0A177CXK4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1079664</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042628.1">
        <property type="nucleotide sequence ID" value="XM_018173857.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CXK4"/>
    <dbReference type="STRING" id="1460663.A0A177CXK4"/>
    <dbReference type="GeneID" id="28757343"/>
    <dbReference type="InParanoid" id="A0A177CXK4"/>
    <dbReference type="OrthoDB" id="3525185at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053178">
        <property type="entry name" value="Osmoadaptation_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38111:SF11">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38111">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG12263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="419" mass="47697" checksum="EB7FD2CFA245F3F1" modified="2016-09-07" version="1">MTNSTMTGQKRRKKREKYVMQTVWEVLPEQVVSSISTMTMQISQRHALNENFYGNFLAYFTTAGEAGDIQNRQTWLHRLPDFAADGSNGALELAVRATASTFSFAKTRHPPLMQDALKLYGRSLNQHVHILKTKKKVTLHTVSTSVMLSIFEAMNATTASAYRQHISGAAELVRLAGPGECCNGVLCQLFFHIRVQMAFVYLTTKQEDKYSICSEEVLRESLSYFYKFPVFQRLINHITRLTALYLQLEDNDNRRTPDLMDLEEYMQIKSDVDALWFEYELSAEEQGQSLFWVTPSGSTEYRDAYTALCVAYFASARALFSILAPRLAASYLDFTDHYQQMIDIAEYLGGLKIGCAFMRMATPLYLVAMHANNKEQREIAIGIFEEWRVVGLGGMSALALESIYRRQGLDKGEIAIRVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177D095</accession>
    <name>A0A177D095_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CC84DRAFT_1081137</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018043153.1">
        <property type="nucleotide sequence ID" value="XM_018173919.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177D095"/>
    <dbReference type="GeneID" id="28757405"/>
    <dbReference type="InParanoid" id="A0A177D095"/>
    <dbReference type="OrthoDB" id="4139357at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF156">
        <property type="entry name" value="TRANSPORTER, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="50"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="176"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="205"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="248"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="274"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="314"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="349"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="378"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="403"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="439"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="521"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="53"/>
            <end position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAG12788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="560" mass="60191" checksum="759AFDA3070358D4" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177D0J3</accession>
    <name>A0A177D0J3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Purine transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_1192821</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family. Azg-like subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018043112.1">
        <property type="nucleotide sequence ID" value="XM_018181262.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177D0J3"/>
    <dbReference type="STRING" id="1460663.A0A177D0J3"/>
    <dbReference type="GeneID" id="28764748"/>
    <dbReference type="InParanoid" id="A0A177D0J3"/>
    <dbReference type="OrthoDB" id="431212at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005345">
        <property type="term" value="F:purine nucleobase transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015853">
        <property type="term" value="P:adenine transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015854">
        <property type="term" value="P:guanine transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045018">
        <property type="entry name" value="Azg-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006043">
        <property type="entry name" value="NCS2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43337:SF3">
        <property type="entry name" value="PURINE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43337">
        <property type="entry name" value="XANTHINE/URACIL PERMEASE C887.17-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00860">
        <property type="entry name" value="Xan_ur_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="150"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="185"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="246"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="370"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="407"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="478"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAG12747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="594" mass="64908" checksum="7090D26C03DDF27C" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177D0J9</accession>
    <name>A0A177D0J9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SUZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1212417</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018043303.1">
        <property type="nucleotide sequence ID" value="XM_018182452.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177D0J9"/>
    <dbReference type="STRING" id="1460663.A0A177D0J9"/>
    <dbReference type="GeneID" id="28765938"/>
    <dbReference type="InParanoid" id="A0A177D0J9"/>
    <dbReference type="OrthoDB" id="5422283at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024771">
        <property type="entry name" value="SUZ"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51673">
        <property type="entry name" value="SUZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SUZ" evidence="2">
        <location>
            <begin position="59"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG12938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="255" mass="28293" checksum="9AEA5565B74484A1" modified="2016-09-07" version="1">MPPKPRALADAWDDDWESLADKEVDAQQKNEPAPKVKLSQKERRAQHAEQQKMLWDSAENPEPMLFLDARNNVPVAPQATFKPAVTLLARKPKAPAGMAGLTLDDDDSEEERRKKSEAEFEERKARAQKERAEKERRYAEARDRIFGKDANSDESRGASPRRAGKGRGGRGGRDSQPRSSNEQSPARPSASRQLFEPAYSPKPGSKFVQRQDGSTSRPSTPNDQEKPVREPRGPQATGRGGRGFAPRGNRTGTVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177D0W4</accession>
    <name>A0A177D0W4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">GMC oxidoreductase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CC84DRAFT_1212545</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG13091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018043456.1">
        <property type="nucleotide sequence ID" value="XM_018182463.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177D0W4"/>
    <dbReference type="STRING" id="1460663.A0A177D0W4"/>
    <dbReference type="GeneID" id="28765949"/>
    <dbReference type="InParanoid" id="A0A177D0W4"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF138">
        <property type="entry name" value="DEHYDROGENASE PKFF-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008058843" evidence="5">
        <location>
            <begin position="19"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="6">
        <location>
            <begin position="317"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="542"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="586"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="282"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="541"/>
            <end position="542"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="587"/>
            <end position="588"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAG13091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="605" mass="64628" checksum="31CC417A893405A1" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177D1N8</accession>
    <name>A0A177D1N8_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Nucleoporin Nup120/160</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CC84DRAFT_1193020</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG13040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018043405.1">
        <property type="nucleotide sequence ID" value="XM_018181268.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177D1N8"/>
    <dbReference type="STRING" id="1460663.A0A177D1N8"/>
    <dbReference type="GeneID" id="28764754"/>
    <dbReference type="InParanoid" id="A0A177D1N8"/>
    <dbReference type="OrthoDB" id="67716at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059141">
        <property type="entry name" value="Beta-prop_Nup120_160"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056548">
        <property type="entry name" value="HEAT_Nup120"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021717">
        <property type="entry name" value="Nucleoporin_Nup160"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048884">
        <property type="entry name" value="Nup120_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21286">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP160"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21286:SF0">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP160"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11715">
        <property type="entry name" value="Beta-prop_Nup120_160"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23300">
        <property type="entry name" value="HEAT_Nup120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21486">
        <property type="entry name" value="NUP120_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nucleoporin Nup120/160 beta-propeller" evidence="4">
        <location>
            <begin position="82"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoporin Nup120 helical" evidence="5">
        <location>
            <begin position="653"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoporin nup120-like HEAT repeat" evidence="6">
        <location>
            <begin position="879"/>
            <end position="1047"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF11715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF21486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF23300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAG13040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1217" mass="137271" checksum="BDE7AF0F962F6C45" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BTJ4</accession>
    <name>A0A177BTJ4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF4939 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1241066</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441578">
        <property type="protein sequence ID" value="OAF98465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018028831.1">
        <property type="nucleotide sequence ID" value="XM_018184042.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BTJ4"/>
    <dbReference type="STRING" id="1460663.A0A177BTJ4"/>
    <dbReference type="GeneID" id="28767528"/>
    <dbReference type="InParanoid" id="A0A177BTJ4"/>
    <dbReference type="OrthoDB" id="3686619at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAF98465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="148" mass="16056" checksum="0F218F9B5D58039C" modified="2016-09-07" version="1">MATPASSAGSRATTGSSASGPTSNQATVLAAQASEIQQLKEQMAELIGQLQVQAAGAVATNIAPKIQFKVPELFNGDKEKLKPFLTNMDLYCRYNKQTLATDQDKILAAGMHMTRRAAKWMQPLTDDYLKNENTIAKCGTETKKTFKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BUZ2</accession>
    <name>A0A177BUZ2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1106246</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441574">
        <property type="protein sequence ID" value="OAF98478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018028844.1">
        <property type="nucleotide sequence ID" value="XM_018175137.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BUZ2"/>
    <dbReference type="GeneID" id="28758623"/>
    <dbReference type="InParanoid" id="A0A177BUZ2"/>
    <dbReference type="OrthoDB" id="3795305at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAF98478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="169" mass="18998" checksum="54AF0A731B30F7EF" modified="2016-09-07" version="1" fragment="single">PHSVGWLIPNEGSIYKPVFIAHSVVSAIWLLYKTLPEGTLPNNAWGRLVCAAKALALEEEEEEEGQGSEPPPKRPSPLAIVSTPRRARTDTNEALSIHSQPSKPSKPDKQPEDLPRHRMVVSNNNRRYEWECRKRLALLYERERLTLGLVAPNNRATTKEKAAYASITQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BVU6</accession>
    <name>A0A177BVU6_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF6987 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_1169757</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441563">
        <property type="protein sequence ID" value="OAF99050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029416.1">
        <property type="nucleotide sequence ID" value="XM_018179748.1"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177BVU6"/>
    <dbReference type="GeneID" id="28763234"/>
    <dbReference type="InParanoid" id="A0A177BVU6"/>
    <dbReference type="OrthoDB" id="3937590at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.20">
        <property type="entry name" value="Apolipoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022124">
        <property type="entry name" value="DUF3659"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054256">
        <property type="entry name" value="DUF6987"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39461">
        <property type="entry name" value="LEA DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_8G04920)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39461:SF1">
        <property type="entry name" value="LEA DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_8G04920)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12396">
        <property type="entry name" value="DUF3659"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22485">
        <property type="entry name" value="DUF6987"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1594"/>
            <end position="1612"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6987" evidence="3">
        <location>
            <begin position="1448"/>
            <end position="1645"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="385"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="788"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="157"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="208"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="244"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="394"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="423"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="797"/>
            <end position="814"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAF99050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="1677" mass="176987" checksum="B29003448068474B" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BW69</accession>
    <name>A0A177BW69_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Mediator of RNA polymerase II transcription subunit 14</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">Mediator complex subunit 14</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CC84DRAFT_1264041</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the Mediator complex subunit 14 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441561">
        <property type="protein sequence ID" value="OAF99662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030028.1">
        <property type="nucleotide sequence ID" value="XM_018185277.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BW69"/>
    <dbReference type="FunCoup" id="A0A177BW69">
        <property type="interactions" value="217"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177BW69"/>
    <dbReference type="GeneID" id="28768763"/>
    <dbReference type="InParanoid" id="A0A177BW69"/>
    <dbReference type="OrthoDB" id="205099at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070847">
        <property type="term" value="C:core mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055122">
        <property type="entry name" value="Med14_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013947">
        <property type="entry name" value="Mediator_Med14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12809">
        <property type="entry name" value="MEDIATOR COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12809:SF2">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08638">
        <property type="entry name" value="Med14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26204">
        <property type="entry name" value="Med14_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0010">Activator</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 9" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Mediator complex subunit MED14 N-terminal" evidence="11">
        <location>
            <begin position="87"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1032"/>
            <end position="1075"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="53"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1039"/>
            <end position="1055"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OAF99662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="1075" mass="120335" checksum="AF22AFFD0A7241B5" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BXB9</accession>
    <name>A0A177BXB9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Peptidase C15, pyroglutamyl peptidase I-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CC84DRAFT_1169136</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C15 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441561">
        <property type="protein sequence ID" value="OAF99600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029966.1">
        <property type="nucleotide sequence ID" value="XM_018179581.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BXB9"/>
    <dbReference type="GeneID" id="28763067"/>
    <dbReference type="InParanoid" id="A0A177BXB9"/>
    <dbReference type="OrthoDB" id="407146at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.20">
        <property type="entry name" value="Peptidase C15, pyroglutamyl peptidase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016125">
        <property type="entry name" value="Peptidase_C15-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036440">
        <property type="entry name" value="Peptidase_C15-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23402">
        <property type="entry name" value="PROTEASE FAMILY C15 PYROGLUTAMYL-PEPTIDASE I-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23402:SF1">
        <property type="entry name" value="PYROGLUTAMYL-PEPTIDASE I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01470">
        <property type="entry name" value="Peptidase_C15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53182">
        <property type="entry name" value="Pyrrolidone carboxyl peptidase (pyroglutamate aminopeptidase)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0788">Thiol protease</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAF99600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="278" mass="30732" checksum="6552FD6F567F6590" modified="2016-09-07" version="1">MPRAWASTARQPPPVEGEKPVTVLVTGFGPFLDQFPRNSSWEIASTLPALIPSSATNPTPIHIHVHHEPIRVAYNKVVNLVPHLLPPGSHQHPAPDIVLHIGLAAGRTFYTLEQGSHGRGYGKIPDVDGEKFADEDAEARFPKEIFPPVLQTSFDTADALTRWRENLEYEDPESESLRGRAPDVRISPDAGNFMCGFIYYNSLAHYYEKKEDERPVAFLHVPDLSDSEEKLAIGRKVAVSLIKALVESRRQVGVVDGTARLAKKGDEQEVAGMDVNFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BXG1</accession>
    <name>A0A177BXG1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_1222362</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the multicopper oxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441560">
        <property type="protein sequence ID" value="OAG00033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030398.1">
        <property type="nucleotide sequence ID" value="XM_018183361.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BXG1"/>
    <dbReference type="STRING" id="1460663.A0A177BXG1"/>
    <dbReference type="GeneID" id="28766847"/>
    <dbReference type="InParanoid" id="A0A177BXG1"/>
    <dbReference type="OrthoDB" id="2121828at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033573">
        <property type="term" value="C:high-affinity iron permease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004322">
        <property type="term" value="F:ferroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010106">
        <property type="term" value="P:cellular response to iron ion starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033215">
        <property type="term" value="P:reductive iron assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033138">
        <property type="entry name" value="Cu_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002355">
        <property type="entry name" value="Cu_oxidase_Cu_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF361">
        <property type="entry name" value="IRON TRANSPORT MULTICOPPER OXIDASE FET3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00079">
        <property type="entry name" value="MULTICOPPER_OXIDASE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00080">
        <property type="entry name" value="MULTICOPPER_OXIDASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Plastocyanin-like" evidence="7">
        <location>
            <begin position="2"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="5">
        <location>
            <begin position="84"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="6">
        <location>
            <begin position="315"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAG00033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="505" mass="56364" checksum="D0F9C9FB0092E2CE" modified="2016-09-07" version="1">MNETTSLHFHGMYQNGTVAADGPVGVAQCGIAPGRYFQYRFVGNPAGTHWWHSHEKAQYTDGLRGKMIIHDPVWEASLKVHRQIYLSVSDWWHQQSPFMVHDYLSPNNTDGSLPTPNSFLLNDSRAPPRFRLKRDRRYLVRIVSFAGLVCGQFHIANHTLTVVAIDGEPVRPAITDTIAICAGQSYDFIVLGNQYEQAANYILKMTTDMLTGPIPSSQTRALIGDIALENNTSIAAGISPNGSFTGPYGSQGVSYIPTLLNFNWTAQGILDDATLVPLDNEPLFKNVTRRINFRTNQVYYEGIGSRISIGIQPYTEPRVPSLQSALTTGQLALDWTTYGPGTSPYVVRHNDIVEIYMENPQIWPHPMHLHGHNFQIAGRGLGSWDGNEDSLYQTPARRNNLVIPPFGWFLIRFIADNPGVWFLHCHIDLHLVGGMAATIVEAPDVLQLQQRIPIQNIEACKADYRCSVGTCNCRLDKLSEEESNEQCNTIFNNVNPARYGALLPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BXS9</accession>
    <name>A0A177BXS9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1168847</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441560">
        <property type="protein sequence ID" value="OAF99935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030301.1">
        <property type="nucleotide sequence ID" value="XM_018179500.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BXS9"/>
    <dbReference type="GeneID" id="28762986"/>
    <dbReference type="InParanoid" id="A0A177BXS9"/>
    <dbReference type="OrthoDB" id="3935253at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="323"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="331"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="363"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAF99935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="385" mass="42825" checksum="51B6E191D231EEC2" modified="2016-09-07" version="1">MITDTTSLLALKQPKQESAKHWFTRHLLRSAPRQTREDTHQGKIIKQMSLRRPRTAPPNRPSTAPSSGPAARDELALPPTMPYVWLQHSPPCSELKAPPGAARAGLDVLLDVDAWLATSKPSSPLMGGLSYWREGNPADADETVNVQYAIPIIQEPNDERLSPSRSQQFRSLCRRAKMQVRMPSIRRVKSPRAIEEDNPRSESAAILTVPYEQTQPSEVPYFATRLTTTHPRIRPSTATAAFPPMGAVIDRRHLPNIDLPLRRDSPGSVQLRELECEMERLALGQSPFTGSNLRPEALSAAHLPREDSMGSFSSAPTYFSGMPPPSYKSRPASSHPASILTTSSFGCIDGMNPEQRQLSQRRAVQKQRSMKGRLRKLAKKANIRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BYR6</accession>
    <name>A0A177BYR6_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 16">Histone-lysine N-methyltransferase, H3 lysine-4 specific</fullName>
            <ecNumber evidence="3 16">2.1.1.354</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">CC84DRAFT_1180521</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalytic component of the COMPASS (Set1C) complex that specifically mono-, di- and trimethylates histone H3 to form H3K4me1/2/3. Binds RNAs which might negatively affect its histone methyltransferase activity. COMPASS recognizes ubiquitinated H2B on one face of the nucleosome which stimulates the methylation of H3 on the opposing face.</text>
    </comment>
    <comment type="function">
        <text evidence="16">Catalytic component of the COMPASS (Set1C) complex that specifically mono-, di- and trimethylates histone H3 to form H3K4me1/2/3. COMPASS recognizes ubiquitinated H2B on one face of the nucleosome which stimulates the methylation of H3 on the opposing face.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-lysyl(4)-[histone H3] + 3 S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:60260"/>
            <dbReference type="Rhea" id="RHEA-COMP:15537"/>
            <dbReference type="Rhea" id="RHEA-COMP:15547"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="EC" id="2.1.1.354"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:60272"/>
            <dbReference type="Rhea" id="RHEA-COMP:15537"/>
            <dbReference type="Rhea" id="RHEA-COMP:15540"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="ChEBI" id="CHEBI:61976"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>N(6)-methyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-methionine = N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:60268"/>
            <dbReference type="Rhea" id="RHEA-COMP:15540"/>
            <dbReference type="Rhea" id="RHEA-COMP:15543"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61929"/>
            <dbReference type="ChEBI" id="CHEBI:61976"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="16">Component of the COMPASS (Set1C) complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Component of the Set1C/COMPASS complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 16">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.1.1.354" evidence="3 16"/>
    <dbReference type="EMBL" id="KV441559">
        <property type="protein sequence ID" value="OAG00513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030878.1">
        <property type="nucleotide sequence ID" value="XM_018180480.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BYR6"/>
    <dbReference type="FunCoup" id="A0A177BYR6">
        <property type="interactions" value="116"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177BYR6"/>
    <dbReference type="GeneID" id="28763966"/>
    <dbReference type="InParanoid" id="A0A177BYR6"/>
    <dbReference type="OrthoDB" id="308383at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048188">
        <property type="term" value="C:Set1C/COMPASS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140999">
        <property type="term" value="F:histone H3K4 trimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024657">
        <property type="entry name" value="COMPASS_Set1_N-SET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003616">
        <property type="entry name" value="Post-SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044570">
        <property type="entry name" value="Set1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017111">
        <property type="entry name" value="Set1_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024636">
        <property type="entry name" value="SET_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45814">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SETD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45814:SF2">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SETD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11764">
        <property type="entry name" value="N-SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11767">
        <property type="entry name" value="SET_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037104">
        <property type="entry name" value="Histone_H3-K4_mtfrase_Set1_fun"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01291">
        <property type="entry name" value="N-SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00508">
        <property type="entry name" value="PostSET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50868">
        <property type="entry name" value="POST_SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51572">
        <property type="entry name" value="SAM_MT43_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9 16" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5 16" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6 16" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10 16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 16" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="7 16" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SET" evidence="18">
        <location>
            <begin position="1042"/>
            <end position="1159"/>
        </location>
    </feature>
    <feature type="domain" description="Post-SET" evidence="19">
        <location>
            <begin position="1168"/>
            <end position="1184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="228"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="286"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="520"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="773"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="13"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="86"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="238"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="286"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="566"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="17">
        <location>
            <begin position="592"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="17">
        <location>
            <begin position="779"/>
            <end position="793"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00044515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRNR" id="PIRNR037104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="OAG00513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="1184" mass="132914" checksum="E9B0383042F6FE40" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BZ77</accession>
    <name>A0A177BZ77_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">SPRY domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CC84DRAFT_1168063</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441558">
        <property type="protein sequence ID" value="OAG00834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031199.1">
        <property type="nucleotide sequence ID" value="XM_018179312.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BZ77"/>
    <dbReference type="STRING" id="1460663.A0A177BZ77"/>
    <dbReference type="GeneID" id="28762798"/>
    <dbReference type="InParanoid" id="A0A177BZ77"/>
    <dbReference type="OrthoDB" id="25503at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd12910">
        <property type="entry name" value="SPRY_SSH4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035780">
        <property type="entry name" value="SPRY_Ssh4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050618">
        <property type="entry name" value="Ubq-SigPath_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12864">
        <property type="entry name" value="RAN BINDING PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="SPRY" evidence="6">
        <location>
            <begin position="229"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="8"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="26"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="75"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="87"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAG00834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="396" mass="43586" checksum="D07A750806F6B672" modified="2016-09-07" version="1">MFKKFKDKLKGDDHNESHQKQEKQPQDASHQQSNLQSNNPFHPNNYTAPPPWQNQSGSHNITPNEKFQPPPGAPPGYAGASSSSGYEPPPGPPPSKDMPQQPPPSWEPPPYHDWTVIPDTALLPPPPSIGYDTSPTANATEEDGGLAYEWCIANPLWPPQNLTPPTHGAIQNGQLALLTPPTFTGNVFPMQQAGHWKCHTQARCRDSALLTNLPMYSVFWDSPLNTHRPKTVYFELKVLGIGSGGYSLSEADAGIAIGFIAPPYPTFRLPGWQRGSLGVHGDDGRKYVNDTFGGVDFTTAFQPGETVGIGMTFALPREPPSYEQSQMGKVMDIDVFFTRNGQREKAWDGNDELDERSEGGTMGLRGECDLFPAVGVFGGVDFEVFFHPSQWMYRPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2023-06-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C0I2</accession>
    <name>A0A177C0I2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_363638</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441560">
        <property type="protein sequence ID" value="OAG00217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030582.1">
        <property type="nucleotide sequence ID" value="XM_018185927.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C0I2"/>
    <dbReference type="GeneID" id="28769413"/>
    <dbReference type="InParanoid" id="A0A177C0I2"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG00217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="221" mass="24428" checksum="1EFCE453E4F290A3" modified="2016-09-07" version="1">MWSGWSPEPKGPISNWTMGEVVQAKALSVWLPRYVGCPSRLLVSSMQSDIAQPLCGHTRPWYVVHCRRGRQQYLVYMTPKHVHTSNSQALDSSSSPAALSLRIVSSSFPHSKQSSKHSAAQPKDNLGAINTLPMALTHRPTTVHTSQCNCRIRTQSLSPNSSPYRIRSPACTPLYRKCTSAAHKRDITCAVAELLCTAQPHLPCLSNQNAIFCRPSRQAQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C0J9</accession>
    <name>A0A177C0J9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">L-arabinitol 4-dehydrogenase</fullName>
            <ecNumber evidence="8">1.1.1.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CC84DRAFT_1154713</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-arabinitol + NAD(+) = L-xylulose + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16381"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17399"/>
            <dbReference type="ChEBI" id="CHEBI:18403"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.12" evidence="8"/>
    <dbReference type="EMBL" id="KV441558">
        <property type="protein sequence ID" value="OAG01163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031528.1">
        <property type="nucleotide sequence ID" value="XM_018176907.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C0J9"/>
    <dbReference type="STRING" id="1460663.A0A177C0J9"/>
    <dbReference type="GeneID" id="28760393"/>
    <dbReference type="InParanoid" id="A0A177C0J9"/>
    <dbReference type="OrthoDB" id="2148442at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050019">
        <property type="term" value="F:L-arabinitol 4-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003939">
        <property type="term" value="F:L-iditol 2-dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006062">
        <property type="term" value="P:sorbitol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05285">
        <property type="entry name" value="sorbitol_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000068">
        <property type="entry name" value="Sorbitol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045306">
        <property type="entry name" value="SDH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161:SF12">
        <property type="entry name" value="L-ARABINITOL 4-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161">
        <property type="entry name" value="SORBITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like N-terminal" evidence="12">
        <location>
            <begin position="46"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="Alcohol dehydrogenase-like C-terminal" evidence="11">
        <location>
            <begin position="197"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00039783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OAG01163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="370" mass="40052" checksum="2EDA936AF83D01E4" modified="2016-09-07" version="1">MSTTTATEVKPSKANIGVYTNPEHDLWVAEAEPSLESVQRGGDLKEGEVLLNIKSTGICGSDIHFWHAGCIGPMIVEDTHILGHESSAQVLAVHPSVKSIQPGDRVAIEPNIPCHTCEPCLTGRYNGCESVLFLSTPPVPGLLRRYLKHPAVWCHKLPDNLTWEDGAMLEPLSVALAGMDRAGVKLGDPVVVCGAGPIGLVTALCCRAAGAAPLLITDIDQGRLDFAKKIIPNILTHKVEFAHTPEVFREKVVAAMGIEPTVAMECTGVESSINGAIQAVKFGGKVFVIGVGKNEMKIPFMRLSTREVDLQFQYRYANTWPKAIRLVQNGLIDLRPLVTHRFDLEQAVEAFKTAADPKTGCIKVQIQSLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C164</accession>
    <name>A0A177C164_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH CENPB-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1102450</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441559">
        <property type="protein sequence ID" value="OAG00360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030725.1">
        <property type="nucleotide sequence ID" value="XM_018174967.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C164"/>
    <dbReference type="GeneID" id="28758453"/>
    <dbReference type="InParanoid" id="A0A177C164"/>
    <dbReference type="OrthoDB" id="3780530at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03221">
        <property type="entry name" value="HTH_Tnp_Tc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH CENPB-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG00360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="59" mass="7077" checksum="9294F43C184C498F" modified="2016-09-07" version="1" fragment="single">LSQQQEVELLQYIKQLTEHILTPIRQMIQSFASYIAKKQVSISWVDRFRQRNKESLISQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C169</accession>
    <name>A0A177C169_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1155464</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441559">
        <property type="protein sequence ID" value="OAG00548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030913.1">
        <property type="nucleotide sequence ID" value="XM_018176935.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C169"/>
    <dbReference type="STRING" id="1460663.A0A177C169"/>
    <dbReference type="GeneID" id="28760421"/>
    <dbReference type="InParanoid" id="A0A177C169"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF272">
        <property type="entry name" value="NAD(P)-BINDING ROSSMANN-FOLD SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG00548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="335" mass="35702" checksum="C8EAD638409E51DD" modified="2016-09-07" version="1">MGRYTAVHANPQGVGDARPTALQIIQDEGLEGKLVGKVIVLTGATSGIGLETARALSTTGATLFLTARDLAKASESLAGILEPGRVSLVPMDNASFSSVRAAAQQILAHSHNKINILIANAGIMGVPSLTLTEDGHESHFAVNHLSHFLLFSLLKDALLAASTPAFNSRAVIVASSAHRAGPFPADHDYSFSNTPYKHGKAYANSKLANIYMANYLDRHYGGRGLHATSVHPGAILTNITRYSDPSVIDAILKMPHLVPIFKSAEQGGATTVVAAVGKEWEGRGGKYLEDCEEAGRGEDDGNVFMLGYTTWTYDEGEEERLWKDSAHFVGVEAHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C176</accession>
    <name>A0A177C176_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">DNAJ domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CC84DRAFT_1168479</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Endomembrane system</location>
            <topology evidence="5">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441559">
        <property type="protein sequence ID" value="OAG00370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030735.1">
        <property type="nucleotide sequence ID" value="XM_018179404.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C176"/>
    <dbReference type="FunCoup" id="A0A177C176">
        <property type="interactions" value="28"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177C176"/>
    <dbReference type="GeneID" id="28762890"/>
    <dbReference type="InParanoid" id="A0A177C176"/>
    <dbReference type="OrthoDB" id="413400at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052606">
        <property type="entry name" value="DnaJ_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44653">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44653:SF2">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0732">Signal</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008057603" evidence="8">
        <location>
            <begin position="21"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="157"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="9">
        <location>
            <begin position="44"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="206"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="352"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="243"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="370"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="384"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAG00370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="394" mass="44304" checksum="72E6E69CCDEEF6FB" modified="2016-09-07" version="1">MKPSALSALVLCLFAAFAAAWTKEDHEIFRLRDEVALHSGENVTFYDLLGVKPSASQDELTKAYRKKSRDLHPDKARRNFEAKRVLENKKKGKKVTKPASKKEIDAYMKEATSAYQRLSVVANLLKGESRERYDHFLRNGFPKWKGTGYYYSRYRPGLGSVLFGLFAVMGGGVHYYTLVMGWKRRREFVERYIRHARRTAWGDDTGINGIPGVDTPPVNTENWGDDSDEAPQEMAPMNRRQKRAMEKENKKDKKSAVAKKARSSGISTPVEAKLTSGPQGAKKRIVADNGKVLVVDSAGNVFLEEESDEGLKQEFLLDPDEEPKPTIFDTMLFKLPKYAYNQTAGRVLGNTQAVEEPLLEPSDVPEEEAALNNATANNLNGETRKRKAKARAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C179</accession>
    <name>A0A177C179_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">U6 snRNA-associated Sm-like protein LSm6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CC84DRAFT_1168648</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Component of LSm protein complexes, which are involved in RNA processing and may function in a chaperone-like manner, facilitating the efficient association of RNA processing factors with their substrates. Component of the cytoplasmic LSM1-LSM7 complex, which is thought to be involved in mRNA degradation by activating the decapping step in the 5'-to-3' mRNA decay pathway. Component of the nuclear LSM2-LSM8 complex, which is involved in splicing of nuclear mRNAs. LSM2-LSM8 associates with multiple snRNP complexes containing the U6 snRNA (U4/U6 di-snRNP, spliceosomal U4/U6.U5 tri-snRNP, and free U6 snRNP). It binds directly to the 3'-terminal U-tract of U6 snRNA and plays a role in the biogenesis and stability of the U6 snRNP and U4/U6 snRNP complexes. LSM2-LSM8 probably also is involved degradation of nuclear pre-mRNA by targeting them for decapping, and in processing of pre-tRNAs, pre-rRNAs and U3 snoRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 15">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the snRNP Sm proteins family. SmF/LSm6 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV441559">
        <property type="protein sequence ID" value="OAG00558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030923.1">
        <property type="nucleotide sequence ID" value="XM_018179448.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C179"/>
    <dbReference type="FunCoup" id="A0A177C179">
        <property type="interactions" value="776"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177C179"/>
    <dbReference type="GeneID" id="28762934"/>
    <dbReference type="InParanoid" id="A0A177C179"/>
    <dbReference type="OrthoDB" id="268799at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990726">
        <property type="term" value="C:Lsm1-7-Pat1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005732">
        <property type="term" value="C:sno(s)RNA-containing ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005688">
        <property type="term" value="C:U6 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008266">
        <property type="term" value="F:poly(U) RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030620">
        <property type="term" value="F:U2 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000290">
        <property type="term" value="P:deadenylation-dependent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01726">
        <property type="entry name" value="LSm6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000037">
        <property type="entry name" value="U6 snRNA-associated Sm-like protein LSm6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016487">
        <property type="entry name" value="Lsm6/sSmF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11021">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN F SNRNP-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11021:SF1">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 15" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="11 15" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="12 15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13 15" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="10 15" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="9 15" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="8" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Sm" evidence="17">
        <location>
            <begin position="18"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00025365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRNR" id="PIRNR006609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="OAG00558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="89" mass="9472" checksum="8E09F0B8F8E8279C" modified="2016-09-07" version="1">MATNGDSPDTAAADTSRDPSGFLSEIIGAPVTVKLNSGIVYKGDLQSVDGYMNIALERCKEWSDGKLVRSWGDAFVRGNNVTYISADNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C214</accession>
    <name>A0A177C214_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1100427</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441557">
        <property type="protein sequence ID" value="OAG01485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031850.1">
        <property type="nucleotide sequence ID" value="XM_018174864.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C214"/>
    <dbReference type="GeneID" id="28758350"/>
    <dbReference type="InParanoid" id="A0A177C214"/>
    <dbReference type="OrthoDB" id="3926209at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843:SF3">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="58"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="250"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="250"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="273"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG01485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="283" mass="30810" checksum="C9A072C6D1798292" modified="2016-09-07" version="1">MADTEDQTPIEETPADDIEMDEGADAGAGADEEANLTELEPETPKLVLFSDLMKSPIIEILVGSGAEQTTYSAHEAVLVKSPAFAAKVEQFAAGGPRQITMSDVDVDAMGSAVEYLYTGEYFPKKTSSGRDAPLEKDPRQPTPDDDGLGLLVHARIYTLADRLQLPSLKSLAHSKIHRTASTAKGELAYARYVYKESNPEDHTIRKPVAAFWATRSFSLRHEAEPEFRAMCLEFPQFSYDVLQLVLDNQEKGKGRGGDGESSHRGPAVVPGSSRKRARVSQAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C2E6</accession>
    <name>A0A177C2E6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">p-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_1221103</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the activator 1 small subunits family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441557">
        <property type="protein sequence ID" value="OAG01616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031981.1">
        <property type="nucleotide sequence ID" value="XM_018183227.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C2E6"/>
    <dbReference type="FunCoup" id="A0A177C2E6">
        <property type="interactions" value="744"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177C2E6"/>
    <dbReference type="GeneID" id="28766713"/>
    <dbReference type="InParanoid" id="A0A177C2E6"/>
    <dbReference type="OrthoDB" id="4199794at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031390">
        <property type="term" value="C:Ctf18 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005663">
        <property type="term" value="C:DNA replication factor C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031391">
        <property type="term" value="C:Elg1 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031389">
        <property type="term" value="C:Rad17 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003689">
        <property type="term" value="F:DNA clamp loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902983">
        <property type="term" value="P:DNA strand elongation involved in mitotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070914">
        <property type="term" value="P:UV-damage excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18140">
        <property type="entry name" value="HLD_clamp_RFC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000012">
        <property type="entry name" value="Replication factor C subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.272.10:FF:000007">
        <property type="entry name" value="Replication factor C subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000107">
        <property type="entry name" value="Replication factor C subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.272.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050238">
        <property type="entry name" value="DNA_Rep/Repair_Clamp_Loader"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013748">
        <property type="entry name" value="Rep_factorC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047854">
        <property type="entry name" value="RFC_lid"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001679">
        <property type="entry name" value="PRK00440.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669">
        <property type="entry name" value="REPLICATION FACTOR C / DNA POLYMERASE III GAMMA-TAU SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669:SF5">
        <property type="entry name" value="REPLICATION FACTOR C SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08542">
        <property type="entry name" value="Rep_fac_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="post-AAA+ oligomerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="7">
        <location>
            <begin position="61"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAG01616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="353" mass="39018" checksum="96CD5A51EC13B1EA" modified="2016-09-07" version="1">MAKAESSKAAASNGIKANPNAQGGANYELPWVEKYRPVYLDDVVGNTETIERLKIIAKDGNMPHVIISGMPGIGKTTSILCLARQLLGDAYKEAVLELNASDERGIDVVRNRIKGFAQKKVTLPPGRQKLVILDEADSMTSGAQQALRRTMEIYSSTTRFAFACNQSNKIIEPLQSRCAILRYARLTDAQIVRRLMQVCEAEQVQFSDDGVAALVFSAEGDMRQAINNLQSTHAGFGFVNGDNVFRVVDSPHPIKVQAMIKACHECRVDDALTTLKELWDLGYSCHDIISTMFKVTKTIDSLSEHAKLEFIKEIGFTHMRILEGVQTLLQLSGCIARLCKINMQPQLFALPSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C421</accession>
    <name>A0A177C421_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cohesin loading factor-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CC84DRAFT_1167808</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SCC4/mau-2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441557">
        <property type="protein sequence ID" value="OAG01632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031997.1">
        <property type="nucleotide sequence ID" value="XM_018179266.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C421"/>
    <dbReference type="STRING" id="1460663.A0A177C421"/>
    <dbReference type="GeneID" id="28762752"/>
    <dbReference type="InParanoid" id="A0A177C421"/>
    <dbReference type="OrthoDB" id="5565328at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007064">
        <property type="term" value="P:mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019440">
        <property type="entry name" value="MAU2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21394">
        <property type="entry name" value="MAU2 CHROMATID COHESION FACTOR HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10345">
        <property type="entry name" value="Cohesin_load"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="4" id="KW-0498">Mitosis</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="13"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="68"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="146"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="191"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="215"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAG01632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="862" mass="95530" checksum="979AA34C6362D0E0" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C569</accession>
    <name>A0A177C569_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1167371</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441556">
        <property type="protein sequence ID" value="OAG02301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032666.1">
        <property type="nucleotide sequence ID" value="XM_018179169.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C569"/>
    <dbReference type="GeneID" id="28762655"/>
    <dbReference type="InParanoid" id="A0A177C569"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG02301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="84" mass="9130" checksum="0B1359E19DCDE203" modified="2016-09-07" version="1">MSTAAASMVGFWVCRWGLPLHPFSSDNDAAAIDANKKYPIAQGTRLNALQLSKASCHVGSGALRRHQSRPPHSRHGVAAQWRSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C5Q9</accession>
    <name>A0A177C5Q9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF1593-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_1167334</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441556">
        <property type="protein sequence ID" value="OAG02219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032584.1">
        <property type="nucleotide sequence ID" value="XM_018179157.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C5Q9"/>
    <dbReference type="STRING" id="1460663.A0A177C5Q9"/>
    <dbReference type="GeneID" id="28762643"/>
    <dbReference type="InParanoid" id="A0A177C5Q9"/>
    <dbReference type="OrthoDB" id="3592035at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016799">
        <property type="term" value="F:hydrolase activity, hydrolyzing N-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.245.10">
        <property type="entry name" value="Ribonucleoside hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036452">
        <property type="entry name" value="Ribo_hydro-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048527">
        <property type="entry name" value="Sde182_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011483">
        <property type="entry name" value="Sde182_NH-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21027">
        <property type="entry name" value="Sde0182_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07632">
        <property type="entry name" value="Sde182_NH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53590">
        <property type="entry name" value="Nucleoside hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008057760" evidence="1">
        <location>
            <begin position="27"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="domain" description="Cellulose-binding Sde182 nucleoside hydrolase-like" evidence="2">
        <location>
            <begin position="43"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="Cellulose-binding Sde182 C-terminal" evidence="3">
        <location>
            <begin position="397"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF21027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAG02219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="486" mass="53812" checksum="A27E83B5B985A08B" modified="2016-09-07" version="1">MLGLSTVLSQALLSFAGLASLGVGAATPSERQCENARYENKHRAFVLTDMSNEPDDQMSLVRLLTYSNEIDIRGIGVVTSVWKNSSIDDETVRLVIHAYGNVTESLDANSPKAAPYPSASELLSKVHVGHPVYGLASLQLNTSDAALALVKAGDEASPTDPLYVQCWGGAAVLAEALHLVSSIRSANATSAFVSKLRVYSISDQDDAGPWIRQHFPALSYIVSLHSFSEYGRATWNGISGELFRFFDIGGPDSSLVTNDWLQSHIRLGPLGAHYPRFDFIMEGDTPAFFPLIRNGLGDPEHPEWGSWGGRWKALDASGKVNVFTDATDWVVGANGQTYLTSYGTIWRWRREYQFDFAARMQWTLGKAYEETNHAPVAIVNGSCGPEVLQMAYKKNKTVLLDASASWDPDGDELRWKWFHYLDVTERVEGKSPFPSKFVRVEELGENGGVVAVTPLYNHTIHLILQLEDNRDMELTTYRRIILYPTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C5R2</accession>
    <name>A0A177C5R2_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">aldehyde dehydrogenase (NAD(+))</fullName>
            <ecNumber evidence="3">1.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_1252829</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>an aldehyde + NAD(+) + H2O = a carboxylate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:16185"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.2.1.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.3" evidence="3"/>
    <dbReference type="EMBL" id="KV441556">
        <property type="protein sequence ID" value="OAG02222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032587.1">
        <property type="nucleotide sequence ID" value="XM_018184367.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C5R2"/>
    <dbReference type="STRING" id="1460663.A0A177C5R2"/>
    <dbReference type="GeneID" id="28767853"/>
    <dbReference type="InParanoid" id="A0A177C5R2"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046394">
        <property type="term" value="P:carboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07091">
        <property type="entry name" value="ALDH_F1-2_Ald2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000050">
        <property type="entry name" value="Aldehyde dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000026">
        <property type="entry name" value="Aldehyde dehydrogenase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000012">
        <property type="entry name" value="Betaine aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11699">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="7">
        <location>
            <begin position="48"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00049194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAG02222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="520" mass="57089" checksum="628EB6BE92B2133F" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C628</accession>
    <name>A0A177C628_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Six-hairpin glycosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1126571</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441556">
        <property type="protein sequence ID" value="OAG02339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032704.1">
        <property type="nucleotide sequence ID" value="XM_018175746.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C628"/>
    <dbReference type="STRING" id="1460663.A0A177C628"/>
    <dbReference type="GeneID" id="28759232"/>
    <dbReference type="InParanoid" id="A0A177C628"/>
    <dbReference type="OrthoDB" id="4104179at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005198">
        <property type="entry name" value="Glyco_hydro_76"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053169">
        <property type="entry name" value="MUG_Protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47791:SF2">
        <property type="entry name" value="ENDO MANNANASE, GH76 FAMILY (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47791">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 191 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03663">
        <property type="entry name" value="Glyco_hydro_76"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="572"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="573"/>
            <end position="592"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG02339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="625" mass="69259" checksum="F3901E81D7CA7C41" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C6R9</accession>
    <name>A0A177C6R9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">CBS-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CC84DRAFT_1207468</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG02569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032934.1">
        <property type="nucleotide sequence ID" value="XM_018182103.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C6R9"/>
    <dbReference type="STRING" id="1460663.A0A177C6R9"/>
    <dbReference type="GeneID" id="28765589"/>
    <dbReference type="InParanoid" id="A0A177C6R9"/>
    <dbReference type="OrthoDB" id="418595at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd17781">
        <property type="entry name" value="CBS_pair_MUG70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17782">
        <property type="entry name" value="CBS_pair_MUG70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06409">
        <property type="entry name" value="PB1_MUG70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051462">
        <property type="entry name" value="CBS_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053793">
        <property type="entry name" value="PB1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000270">
        <property type="entry name" value="PB1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48108">
        <property type="entry name" value="CBS DOMAIN-CONTAINING PROTEIN CBSX2, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48108:SF26">
        <property type="entry name" value="CBS DOMAIN-CONTAINING PROTEIN DDB_G0289609"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00564">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00666">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54277">
        <property type="entry name" value="CAD &amp; PB1 domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51745">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0129">CBS domain</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="646"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="5">
        <location>
            <begin position="97"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="5">
        <location>
            <begin position="164"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="5">
        <location>
            <begin position="267"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="5">
        <location>
            <begin position="333"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="PB1" evidence="6">
        <location>
            <begin position="478"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="578"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="43"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="59"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="76"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAG02569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="673" mass="72750" checksum="83AD8D5C9698C465" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C780</accession>
    <name>A0A177C780_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CC84DRAFT_1218907</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG03604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033969.1">
        <property type="nucleotide sequence ID" value="XM_018183038.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C780"/>
    <dbReference type="STRING" id="1460663.A0A177C780"/>
    <dbReference type="GeneID" id="28766524"/>
    <dbReference type="InParanoid" id="A0A177C780"/>
    <dbReference type="OrthoDB" id="4329349at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF105">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="42"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="98"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="132"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="180"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="214"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="256"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="22"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="305"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="316"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAG03604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="388" mass="42351" checksum="EAA79A5CA3D766F3" modified="2016-09-07" version="1">MPNSQTVELFTLYALGVSFTILRTYARIVAVGVRDLRVDDYLIWLAILIYSAQCALGYNVGFAAHGLDNSGMTPAQRSALSPEDAEYKLRLIGAKIQVAGWTSASCLLWTLKLCVAFFYLRLHDGLTRYKIRIYIGIGLIVTTFITLIMTIYLSCRPFNHYWQISPDPGNACQAAVSKPIIWVMFIGNVSTDVYLFVVPLPMLWQSSLKTYKKLAATLVLSGGILIVVCAILKSVFVLVDPVHGGQLAAAWGTRETFIAVITTNLPMVFPLLKIWLKPWLPTTLNSSSKGRAYKAHGSGFVTIGGGGASASGRSRPGQQSRDASRNMTFDNESEEHIVKGGTAIPLQSVGGTQRSLKKNDIMVSTHVTVTRTDATKDDASSQKSGKSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C7M9</accession>
    <name>A0A177C7M9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1166584</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG02778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033143.1">
        <property type="nucleotide sequence ID" value="XM_018178997.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C7M9"/>
    <dbReference type="GeneID" id="28762483"/>
    <dbReference type="InParanoid" id="A0A177C7M9"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG02778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="77" mass="8326" checksum="21538D94209FF2BC" modified="2016-09-07" version="1">MCIHEHHVKADAATLVAALDNFTAAVQLMKHLEGLTFAYDFQDSITSYGTASHQKLRKTSAKDDAEGSFQKGVPGGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2023-06-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C891</accession>
    <name>A0A177C891_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_970467</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG03351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033716.1">
        <property type="nucleotide sequence ID" value="XM_018188009.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C891"/>
    <dbReference type="GeneID" id="28771495"/>
    <dbReference type="InParanoid" id="A0A177C891"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG03351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="75" mass="8070" checksum="9BBE63445771EB1E" modified="2016-09-07" version="1">MRGIKEGSDADDPTSRTTLYIHYCKLTTRSVQRCGTLTSQKVSMVFLLDMTCVFGVNACGVAMPPALRSSGPGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C8R0</accession>
    <name>A0A177C8R0_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_888893</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG04134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034499.1">
        <property type="nucleotide sequence ID" value="XM_018187804.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C8R0"/>
    <dbReference type="GeneID" id="28771290"/>
    <dbReference type="InParanoid" id="A0A177C8R0"/>
    <dbReference type="OrthoDB" id="10590611at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="127"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG04134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="224" mass="24764" checksum="919D2E1A75145031" modified="2016-09-07" version="1">MDEEGVRSRFTEYLNGHDGGHTSCDSERVHSEDPMGGSHEAQFSDVSLSDEKAHEFATAHNIHIHSSEAAAPLQPPPPPAPHANTTRAQHPLSSYEPLPHEERTPRTSLVRRAFSFVGGTKRRTAKYIIISVLLLFIAAFLIYVFFSKVLPAYSKLRDLKDRLAVLDAFHDTVAAKLGVWLHDGRELVDNVKDMVGDGVDKVVDAANNVLGKVRVSVSHVNLER</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C928</accession>
    <name>A0A177C928_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Actin-like ATPase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1096097</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG03886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034251.1">
        <property type="nucleotide sequence ID" value="XM_018174649.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C928"/>
    <dbReference type="STRING" id="1460663.A0A177C928"/>
    <dbReference type="GeneID" id="28758135"/>
    <dbReference type="InParanoid" id="A0A177C928"/>
    <dbReference type="OrthoDB" id="2963168at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10170">
        <property type="entry name" value="ASKHA_NBD_HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187">
        <property type="entry name" value="ALPHA KINASE/ELONGATION FACTOR 2 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187:SF79">
        <property type="entry name" value="HSP70 FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_1G15200)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG03886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="578" mass="64643" checksum="F328FD6F6F89B3AB" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CA67</accession>
    <name>A0A177CA67_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Rad21/Rec8-like protein N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CC84DRAFT_1095863</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG03668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034033.1">
        <property type="nucleotide sequence ID" value="XM_018174638.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CA67"/>
    <dbReference type="STRING" id="1460663.A0A177CA67"/>
    <dbReference type="GeneID" id="28758124"/>
    <dbReference type="InParanoid" id="A0A177CA67"/>
    <dbReference type="OrthoDB" id="10071381at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030892">
        <property type="term" value="C:mitotic cohesin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007064">
        <property type="term" value="P:mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990414">
        <property type="term" value="P:replication-born double-strand break repair via sister chromatid exchange"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21788">
        <property type="entry name" value="Rad21_Rec8_M_SpRad21p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.580:FF:000004">
        <property type="entry name" value="Double-strand-break repair protein rad21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.580">
        <property type="entry name" value="Structural maintenance of chromosome 1. Chain E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039781">
        <property type="entry name" value="Rad21/Rec8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006910">
        <property type="entry name" value="Rad21_Rec8_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023093">
        <property type="entry name" value="ScpA-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12585:SF69">
        <property type="entry name" value="FI11703P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12585">
        <property type="entry name" value="SCC1 / RAD21 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04825">
        <property type="entry name" value="Rad21_Rec8_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rad21/Rec8-like protein N-terminal" evidence="4">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="235"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="407"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="605"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="263"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="328"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="622"/>
            <end position="633"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAG03668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="639" mass="70193" checksum="7ABD07ADEA820CF2" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CB11</accession>
    <name>A0A177CB11_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Mitochondrial ribosomal protein-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CC84DRAFT_1165138</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL19 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG04755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035120.1">
        <property type="nucleotide sequence ID" value="XM_018178650.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CB11"/>
    <dbReference type="FunCoup" id="A0A177CB11">
        <property type="interactions" value="229"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CB11"/>
    <dbReference type="GeneID" id="28762136"/>
    <dbReference type="InParanoid" id="A0A177CB11"/>
    <dbReference type="OrthoDB" id="432645at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.790:FF:000007">
        <property type="entry name" value="Mitochondrial ribosomal protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001857">
        <property type="entry name" value="Ribosomal_bL19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038657">
        <property type="entry name" value="Ribosomal_bL19_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15680:SF9">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL19M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15680">
        <property type="entry name" value="RIBOSOMAL PROTEIN L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01245">
        <property type="entry name" value="Ribosomal_L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="244"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="264"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAG04755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="278" mass="30453" checksum="4A96A6E30E76AF7F" modified="2016-09-07" version="1">MATAIASAKAGVSQAVLLVAKPPAIAAKSVKGSKLVDAMHRSLYPHLYQQGGGSAPNRKIRQQMGTMKRYKQVEAEREARKVSWFRNKMRTSSSSKLASQPQKPRAIRKACHDPVAAVTSSQLAVHDPTGARTRLFDRANPECARVGDILLVRQRTGEPFAGVCINIRRRGVDTAILLRGQLTRVGIEMWYKVYSPLVEGIEVVQRAQRKTRRARLTYMRKEKHDRGSVENVVRVYLRQKAALGSTDGSKKKGAAAAAAMAGGGKRKGSVKGKKGKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CB15</accession>
    <name>A0A177CB15_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CC84DRAFT_878396</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG03968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034333.1">
        <property type="nucleotide sequence ID" value="XM_018187757.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CB15"/>
    <dbReference type="STRING" id="1460663.A0A177CB15"/>
    <dbReference type="GeneID" id="28771243"/>
    <dbReference type="InParanoid" id="A0A177CB15"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008395">
        <property type="term" value="F:steroid hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050529">
        <property type="entry name" value="CYP450_sterol_14alpha_dmase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24304:SF2">
        <property type="entry name" value="24-HYDROXYCHOLESTEROL 7-ALPHA-HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24304">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 7" id="KW-0349">Heme</keyword>
    <keyword evidence="5 6 7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="66"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="6">
        <location>
            <position position="562"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAG03968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="620" mass="70627" checksum="441449B1BDA21CD6" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CB42</accession>
    <name>A0A177CB42_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Prefoldin subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CC84DRAFT_1166204</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 4">Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Heterohexamer of two PFD-alpha type and four PFD-beta type subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the prefoldin subunit beta family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG04082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034447.1">
        <property type="nucleotide sequence ID" value="XM_018178894.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CB42"/>
    <dbReference type="FunCoup" id="A0A177CB42">
        <property type="interactions" value="720"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CB42"/>
    <dbReference type="GeneID" id="28762380"/>
    <dbReference type="InParanoid" id="A0A177CB42"/>
    <dbReference type="OrthoDB" id="10250441at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd23165">
        <property type="entry name" value="Prefoldin_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.370:FF:000005">
        <property type="entry name" value="Prefoldin subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002777">
        <property type="entry name" value="PFD_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016661">
        <property type="entry name" value="PFDN4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21100">
        <property type="entry name" value="PREFOLDIN SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21100:SF9">
        <property type="entry name" value="PREFOLDIN SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01920">
        <property type="entry name" value="Prefoldin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016477">
        <property type="entry name" value="Prefoldin_subunit_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="39"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="19"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR016477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAG04082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="136" mass="15630" checksum="50489171875B4681" modified="2016-09-07" version="1">MQRRMLSKEDEASAGAEDMEVRREDQEKINRFSSLHQKETAIEDELKAKMKEKEDLEEISGELELVDEEEKVPYKIGDCFVSLPQPEVLELLQSSTEAIDGDVDALKERLDTIHDEMAELKKALYGRFGRSINLET</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CB52</accession>
    <name>A0A177CB52_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CASTOR ACT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1176968</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG04805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035170.1">
        <property type="nucleotide sequence ID" value="XM_018180257.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CB52"/>
    <dbReference type="GeneID" id="28763743"/>
    <dbReference type="InParanoid" id="A0A177CB52"/>
    <dbReference type="OrthoDB" id="58529at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046394">
        <property type="term" value="P:carboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2130.10">
        <property type="entry name" value="VC0802-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027795">
        <property type="entry name" value="CASTOR_ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051719">
        <property type="entry name" value="CASTOR_mTORC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31131:SF6">
        <property type="entry name" value="CASTOR ACT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31131">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13840">
        <property type="entry name" value="ACT_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="ACT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CASTOR ACT" evidence="2">
        <location>
            <begin position="102"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG04805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="386" mass="42031" checksum="86AB9A255F0B4BFF" modified="2016-09-07" version="1">MLAFKDTQLALIHIPLPLYSSFLQSILQLLLPNESRNEHSAFNGNGAVQPPPAWPYEHPFVNISVTPSECSVVCSRKLANDIFVPALNLLDPKSRDRVSITSEDYVVMQVDGEGLDAGQRVLELTSPLALAGISIFFITTYFSDYILVPIRYRSQVVHALEERGFIFEDQTSSYVNPSHHSRQHSSPQSFEVRPPGTPPPATVSELQTRTFATLKRRNIIPTVDSCLRLVQCAGRRDSANSINEGRNRSSMTSAADDALHLGLVKCLISPPYPKFLSLTLTDTEPASLLLDHSLLPNFASDILLGSKDDFLIPITLDLRDLPMESTGIICGVAGRLVGGTAGQLESAVEMSYLSTARAGTVMVAEDELKRALGALRGAENGSSTPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CCV3</accession>
    <name>A0A177CCV3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1164008</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG05484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035849.1">
        <property type="nucleotide sequence ID" value="XM_018178392.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CCV3"/>
    <dbReference type="STRING" id="1460663.A0A177CCV3"/>
    <dbReference type="GeneID" id="28761878"/>
    <dbReference type="InParanoid" id="A0A177CCV3"/>
    <dbReference type="OrthoDB" id="5429716at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="402"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="208"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="265"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="460"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="584"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="209"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="240"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="268"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="303"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="328"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="584"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="602"/>
            <end position="612"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG05484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="727" mass="76171" checksum="4518A93F5EB96987" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CCW2</accession>
    <name>A0A177CCW2_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Spo12-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1144893</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG05494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035859.1">
        <property type="nucleotide sequence ID" value="XM_018176478.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CCW2"/>
    <dbReference type="STRING" id="1460663.A0A177CCW2"/>
    <dbReference type="GeneID" id="28759964"/>
    <dbReference type="InParanoid" id="A0A177CCW2"/>
    <dbReference type="OrthoDB" id="5578329at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007727">
        <property type="entry name" value="Spo12"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05032">
        <property type="entry name" value="Spo12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG05494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="121" mass="13316" checksum="15AFF6EA8574C692" modified="2016-09-07" version="1">MSANVLSNRDTNAQMKPASPQKKADKPEPKSLDAHRQELASRLKENDKTQQYVSPSDSIQSPATQKLSAFRNKQITKKSKPQTLFKTTSSKKIESAKGTAMFADIPKTDQSTNNGEVHAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CD30</accession>
    <name>A0A177CD30_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CC84DRAFT_1091705</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG05554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035919.1">
        <property type="nucleotide sequence ID" value="XM_018174409.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CD30"/>
    <dbReference type="STRING" id="1460663.A0A177CD30"/>
    <dbReference type="GeneID" id="28757895"/>
    <dbReference type="InParanoid" id="A0A177CD30"/>
    <dbReference type="OrthoDB" id="2533084at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF181">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="107"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="137"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="166"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="196"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="225"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="328"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="360"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="402"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="435"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="469"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="500"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="66"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAG05554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="536" mass="57708" checksum="2092F55B7124C416" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2023-06-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CDL8</accession>
    <name>A0A177CDL8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1164197</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG05733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036098.1">
        <property type="nucleotide sequence ID" value="XM_018178441.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CDL8"/>
    <dbReference type="GeneID" id="28761927"/>
    <dbReference type="InParanoid" id="A0A177CDL8"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG05733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="84" mass="9417" checksum="B2CBC265278FA7C9" modified="2016-09-07" version="1" fragment="single">MRSPRALAILCRPTNSSSILRLVSTLKFSTIASEHGPPDRVRQIPPEFINLVQEYLLPEYDAVHIIMGKETGTKDIPLLLSGRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CDV2</accession>
    <name>A0A177CDV2_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Arginine biosynthesis bifunctional protein ArgJ, mitochondrial</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="10">Glutamate N-acetyltransferase</fullName>
                <shortName evidence="10">GAT</shortName>
                <ecNumber evidence="10">2.3.1.35</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="10">Ornithine acetyltransferase</fullName>
                <shortName evidence="10">OATase</shortName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="10">Ornithine transacetylase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="10">Amino-acid acetyltransferase</fullName>
                <ecNumber evidence="10">2.3.1.1</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="10">N-acetylglutamate synthase</fullName>
                <shortName evidence="10">AGS</shortName>
            </alternativeName>
        </domain>
        <component>
            <recommendedName>
                <fullName evidence="10">Arginine biosynthesis bifunctional protein ArgJ alpha chain</fullName>
            </recommendedName>
        </component>
        <component>
            <recommendedName>
                <fullName evidence="10">Arginine biosynthesis bifunctional protein ArgJ beta chain</fullName>
            </recommendedName>
        </component>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CC84DRAFT_723585</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of acetylglutamate from glutamate and acetyl-CoA, and of ornithine by transacetylation between acetylornithine and glutamate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-glutamate + acetyl-CoA = N-acetyl-L-glutamate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24292"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:44337"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.1.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>N(2)-acetyl-L-ornithine + L-glutamate = N-acetyl-L-glutamate + L-ornithine</text>
            <dbReference type="Rhea" id="RHEA:15349"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:44337"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:57805"/>
            <dbReference type="EC" id="2.3.1.35"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="10">Amino-acid biosynthesis; L-arginine biosynthesis; L-ornithine and N-acetyl-L-glutamate from L-glutamate and N(2)-acetyl-L-ornithine (cyclic): step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="10">Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 1/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Heterodimer of an alpha and a beta chain.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="10">The alpha and beta chains are autoproteolytically processed from a single precursor protein within the mitochondrion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the ArgJ family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.35" evidence="10"/>
    <dbReference type="EC" id="2.3.1.1" evidence="10"/>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG05486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035851.1">
        <property type="nucleotide sequence ID" value="XM_018187179.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CDV2"/>
    <dbReference type="FunCoup" id="A0A177CDV2">
        <property type="interactions" value="299"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CDV2"/>
    <dbReference type="GeneID" id="28770665"/>
    <dbReference type="InParanoid" id="A0A177CDV2"/>
    <dbReference type="OrthoDB" id="4199794at2759"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00106"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004042">
        <property type="term" value="F:L-glutamate N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004358">
        <property type="term" value="F:L-glutamate N-acetyltransferase activity, acting on acetyl-L-ornithine as donor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:L-arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006592">
        <property type="term" value="P:ornithine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02152">
        <property type="entry name" value="OAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.70.12:FF:000001">
        <property type="entry name" value="Arginine biosynthesis bifunctional protein ArgJ, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.340:FF:000002">
        <property type="entry name" value="Arginine biosynthesis bifunctional protein ArgJ, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2330.10:FF:000001">
        <property type="entry name" value="Arginine biosynthesis bifunctional protein ArgJ, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2330.10">
        <property type="entry name" value="arginine biosynthesis bifunctional protein suprefamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.340">
        <property type="entry name" value="ArgJ beta chain, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.70.12">
        <property type="entry name" value="L-amino peptidase D-ALA esterase/amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01106">
        <property type="entry name" value="ArgJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002813">
        <property type="entry name" value="Arg_biosynth_ArgJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016117">
        <property type="entry name" value="ArgJ-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042195">
        <property type="entry name" value="ArgJ_beta_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00120">
        <property type="entry name" value="ArgJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003802">
        <property type="entry name" value="PRK05388.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23100">
        <property type="entry name" value="ARGININE BIOSYNTHESIS BIFUNCTIONAL PROTEIN ARGJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23100:SF0">
        <property type="entry name" value="ARGININE BIOSYNTHESIS BIFUNCTIONAL PROTEIN ARGJ, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01960">
        <property type="entry name" value="ArgJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56266">
        <property type="entry name" value="DmpA/ArgJ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4 10" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3 10" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="6 10" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="7 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8 10" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_5023517683" description="Arginine biosynthesis bifunctional protein ArgJ alpha chain" evidence="10">
        <location>
            <begin position="1"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023517682" description="Arginine biosynthesis bifunctional protein ArgJ beta chain" evidence="10">
        <location>
            <begin position="240"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="10">
        <location>
            <position position="240"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="240"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="327"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="457"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="462"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole" evidence="10">
        <location>
            <position position="162"/>
        </location>
    </feature>
    <feature type="site" description="Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole" evidence="10">
        <location>
            <position position="163"/>
        </location>
    </feature>
    <feature type="site" description="Cleavage; by autolysis" evidence="10">
        <location>
            <begin position="239"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OAG05486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="462" mass="49206" checksum="A0E71ADE0FBF98CB" modified="2016-09-07" version="1">MALARPSPRWLTRSRAFTAQVRSYSAPGDGTIPASKKKYIPTSGTYPLGFKAGSAHVGVKASNTRFDDLALVASDTPCAAAAVFTTNKFQAAPVTVSRDMLSKRKGDGVRAVVVNSGCANAVTGKGGIQDAVRMGLETDKQFIEDSNGEDDGQGSRSIVMSTGVIGQRLPIDKIVSKLPHVYYKLGDTHEHWLGAAKAICTTDTFPKLVSKTFTLPGSQEEYHIAGMTKGAGMIHPNMATLLGIICTDAPVSAPLLQSALKEAITKSFNSISIDGDTSTNDTVAILANGAAGGQEITSSSSEDFKAFSATLTDFAIDLAKLVVRDGEGATKFVTIRVTNAKTYEEAKQVGNSIARSPLVKTALYGKDANWGRILCATGYAGVESIIPEQTSVSFIPADGSEELKLLVKGEPEQVDEERAAKILEAEDLEILVRLSEKYDAEATVWTCDFSHEYVTINGDYRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CEC6</accession>
    <name>A0A177CEC6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_827384</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG05090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035455.1">
        <property type="nucleotide sequence ID" value="XM_018187542.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CEC6"/>
    <dbReference type="GeneID" id="28771028"/>
    <dbReference type="InParanoid" id="A0A177CEC6"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG05090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="228" mass="25125" checksum="FAC9A0D0910B9C13" modified="2016-09-07" version="1">MAVDAHGGRPPAGSPRPWRLDWTRRALATPYQRVWRNEPKATVGQRRSDCTFQPTSVVGLPQSRAEGDVEFASTCPWPAGWVRGVGYLGDRMGDRPHAFPPWASCKPCAHRCNVLSTWQEASHVHITMLAATLDQEHVAGTPQCASHQKYRRGCTNSAKLSPPSQLNLPRNDVGPDSHKRRHCVALGMPPTLRRSVLFGLGPPIYVLPDSTKLPHAITTFPPLVRANP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CEH8</accession>
    <name>A0A177CEH8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Galactose oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_1259021</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG05611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035976.1">
        <property type="nucleotide sequence ID" value="XM_018184874.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CEH8"/>
    <dbReference type="STRING" id="1460663.A0A177CEH8"/>
    <dbReference type="GeneID" id="28768360"/>
    <dbReference type="InParanoid" id="A0A177CEH8"/>
    <dbReference type="OrthoDB" id="2019572at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02851">
        <property type="entry name" value="E_set_GO_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.80">
        <property type="entry name" value="Galactose oxidase/kelch, beta-propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037293">
        <property type="entry name" value="Gal_Oxidase_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009880">
        <property type="entry name" value="Glyoxal_oxidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015202">
        <property type="entry name" value="GO-like_E_set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32208:SF68">
        <property type="entry name" value="GALACTOSE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32208">
        <property type="entry name" value="SECRETED PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07250">
        <property type="entry name" value="Glyoxal_oxid_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09118">
        <property type="entry name" value="GO-like_E_set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00612">
        <property type="entry name" value="Kelch"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="Galactose oxidase, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008058060" evidence="2">
        <location>
            <begin position="20"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="3">
        <location>
            <begin position="10"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="3">
        <location>
            <begin position="164"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAG05611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="794" mass="84719" checksum="9DC2BB84E18B8C64" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CEN4</accession>
    <name>A0A177CEN4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Inorganic phosphate transporter-like protein pho88</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1163930</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG05372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035737.1">
        <property type="nucleotide sequence ID" value="XM_018178367.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CEN4"/>
    <dbReference type="FunCoup" id="A0A177CEN4">
        <property type="interactions" value="263"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CEN4"/>
    <dbReference type="GeneID" id="28761853"/>
    <dbReference type="InParanoid" id="A0A177CEN4"/>
    <dbReference type="OrthoDB" id="18139at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045047">
        <property type="term" value="P:protein targeting to ER"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012098">
        <property type="entry name" value="SND3_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28112">
        <property type="entry name" value="SRP-INDEPENDENT TARGETING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28112:SF1">
        <property type="entry name" value="SRP-INDEPENDENT TARGETING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10032">
        <property type="entry name" value="Pho88"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF008756">
        <property type="entry name" value="P_tr_PHO88"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG05372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="191" mass="20844" checksum="44A8297E37ABE8EB" modified="2016-09-07" version="1">MALNPQITNLLIILAFMQISKKVPFDNPDVLNGVRALYILSNAIIAGIYLYVQAQIKKKNDMTVVKYVEPAPMGSGEEPKFVATTVKAYDLQQLQGLFKAQLMGVGMMGVMHIYMKYTNPLLIQSIIPLKGAFEGNLVKVHLFGQPATGDLQRPWKAAGGFMGAMQGGEIKTDKKSIEAAERAGRGGVKDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CEY1</accession>
    <name>A0A177CEY1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF1766-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1144860</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG05472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035837.1">
        <property type="nucleotide sequence ID" value="XM_018176476.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CEY1"/>
    <dbReference type="STRING" id="1460663.A0A177CEY1"/>
    <dbReference type="GeneID" id="28759962"/>
    <dbReference type="InParanoid" id="A0A177CEY1"/>
    <dbReference type="OrthoDB" id="2417614at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053006">
        <property type="entry name" value="Meiosis_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018306">
        <property type="entry name" value="Phage_T5_Orf172_DNA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28094:SF2">
        <property type="entry name" value="BACTERIOPHAGE T5 ORF172 DNA-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28094">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 113 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10544">
        <property type="entry name" value="T5orf172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00974">
        <property type="entry name" value="T5orf172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bacteriophage T5 Orf172 DNA-binding" evidence="2">
        <location>
            <begin position="312"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="270"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="353"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="270"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="353"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="377"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG05472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="452" mass="50904" checksum="AF1DC82C78C4613A" modified="2016-09-07" version="1">MALFTGRTPEALIPRSDSRNPATTCKGITKSGRPCRRAIDARDSSHNNGVLAVASVISDNDDEETGAAAFFCWQHKDQAEHLMAPNAAGSGAQDTHLYPLQERNSIDTLVARLGVLDMEEPETAPQRRRRRSRQENSTSRPPRRINRPPTWDQVQGPLMSVPSDVMAERRRQISQRPEPRTQRKKRSFWTSLCCGSADDDDDYVEVPARPLNKTSRPSETSALLSYIPKSISPQTTSALLTELSKPISGHDEEGYIYIFWLTPESAGPAPSSTASSLLAPPTRPEQGRRTSDVLRQYSVRRPQRPRLDAAEEKNTILLKIGRANNVTRRMHEWTRQCGYSLSLVRFYPYVPSTPTASPQGSPAHSRRPSYNNQRPPDPARRVSEGVRKVPHAHRVERLIHIELAGQRVTKKCDACGKDHREWFEVEASKEGVKGVDEVVKRWVEWAERKDQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CF33</accession>
    <name>A0A177CF33_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Replication factor C subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CC84DRAFT_1258885</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the activator 1 small subunits family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG05438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035803.1">
        <property type="nucleotide sequence ID" value="XM_018184862.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CF33"/>
    <dbReference type="FunCoup" id="A0A177CF33">
        <property type="interactions" value="778"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CF33"/>
    <dbReference type="GeneID" id="28768348"/>
    <dbReference type="InParanoid" id="A0A177CF33"/>
    <dbReference type="OrthoDB" id="4199794at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031390">
        <property type="term" value="C:Ctf18 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005663">
        <property type="term" value="C:DNA replication factor C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031391">
        <property type="term" value="C:Elg1 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031389">
        <property type="term" value="C:Rad17 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003689">
        <property type="term" value="F:DNA clamp loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006272">
        <property type="term" value="P:leading strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18140">
        <property type="entry name" value="HLD_clamp_RFC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000028">
        <property type="entry name" value="Replication factor C subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.272.10:FF:000004">
        <property type="entry name" value="Replication factor C subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000129">
        <property type="entry name" value="Replication factor C subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.272.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050238">
        <property type="entry name" value="DNA_Rep/Repair_Clamp_Loader"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013748">
        <property type="entry name" value="Rep_factorC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047854">
        <property type="entry name" value="RFC_lid"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669">
        <property type="entry name" value="REPLICATION FACTOR C / DNA POLYMERASE III GAMMA-TAU SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669:SF9">
        <property type="entry name" value="REPLICATION FACTOR C SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21960">
        <property type="entry name" value="RCF1-5-like_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08542">
        <property type="entry name" value="Rep_fac_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="post-AAA+ oligomerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="8">
        <location>
            <begin position="75"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00070184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAG05438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="395" mass="43159" checksum="BF9360EDE1AE00A1" modified="2016-09-07" version="1">MSDYEDEMDVDAPAARTSIAFGGDAKKGKRSAANLPVEAEDSLPWVEKYRPSSLDDVEGHKDIIATINKFVDSNRLPHLLLYGPPGTGKTSTVLALARRIYGAKNMRQMVLELNASDDRGIDVVREQIKTFSSTKQIFAAAPKPGEASSLATFKLIILDEADAMTSTAQMALRRIMEKYTANTRFCIIANYTHKLSPALLSRCTRFRFSPLKERDIRNLVDKVIEDEKVNITQEATESLVTLSKGDMRRALNVLQACHASSTPLQPPDQPAPDPSTIVRDQITQTTIYDCIAAPHPADITYILNLLLETGDITQCLKTINTIKTQKGLALADILTALSEELVKNEVPAQTLVTWMSGLADIEHRLSSGGSEAIQTGATIGVVRMGVELLAHGKGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2023-06-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CF72</accession>
    <name>A0A177CF72_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_738876</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG05851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036216.1">
        <property type="nucleotide sequence ID" value="XM_018187241.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CF72"/>
    <dbReference type="GeneID" id="28770727"/>
    <dbReference type="InParanoid" id="A0A177CF72"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="257"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG05851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="277" mass="30059" checksum="9574C76649A6CE03" modified="2016-09-07" version="1">MHPGSAHCTSRTLRHVVGVHRRSRCAAASRRRRWFACCAMGESRRRCWRRSRALDGIIAGQISANLPSGDGIMVWHGSGCPLARRRKRDDAKGVGSSDQGPFRRTAGPMIDTSLVARWLPAATVARTPRWPAARRADGRAAAKWRWAAAAARTRTRQACSACTEPSRAASAAESDAWSVCAAAVWGRQKRARAAVNLAGTWRRLAARPPAPALSPRARQNRTLIRQPRCRAMFLRAPPAANGAREIPGRTALSARFSEPSGAACEGLQSRHGPGRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CFD9</accession>
    <name>A0A177CFD9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Aspartokinase</fullName>
            <ecNumber evidence="7">2.7.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CC84DRAFT_1144841</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>L-aspartate + ATP = 4-phospho-L-aspartate + ADP</text>
            <dbReference type="Rhea" id="RHEA:23776"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57535"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the aspartokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.4" evidence="7"/>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG05457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035822.1">
        <property type="nucleotide sequence ID" value="XM_018176473.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CFD9"/>
    <dbReference type="FunCoup" id="A0A177CFD9">
        <property type="interactions" value="299"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CFD9"/>
    <dbReference type="GeneID" id="28759959"/>
    <dbReference type="InParanoid" id="A0A177CFD9"/>
    <dbReference type="OrthoDB" id="4323675at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004072">
        <property type="term" value="F:aspartate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071266">
        <property type="term" value="P:'de novo' L-methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009090">
        <property type="term" value="P:homoserine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.260:FF:000029">
        <property type="entry name" value="Aspartokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.260:FF:000033">
        <property type="entry name" value="Aspartokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1160.10:FF:000023">
        <property type="entry name" value="Probable aspartokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.260">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="entry name" value="Acetylglutamate kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054352">
        <property type="entry name" value="ACT_Aspartokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001341">
        <property type="entry name" value="Asp_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018042">
        <property type="entry name" value="Aspartate_kinase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00657">
        <property type="entry name" value="asp_kinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21499">
        <property type="entry name" value="ASPARTATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21499:SF59">
        <property type="entry name" value="ASPARTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22468">
        <property type="entry name" value="ACT_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="ACT-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="Carbamate kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00324">
        <property type="entry name" value="ASPARTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ACT" evidence="8">
        <location>
            <begin position="464"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAG05457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="527" mass="57221" checksum="A68F55FBDF39688A" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CFH2</accession>
    <name>A0A177CFH2_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CC84DRAFT_1176368</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG06355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036720.1">
        <property type="nucleotide sequence ID" value="XM_018180216.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CFH2"/>
    <dbReference type="STRING" id="1460663.A0A177CFH2"/>
    <dbReference type="GeneID" id="28763702"/>
    <dbReference type="InParanoid" id="A0A177CFH2"/>
    <dbReference type="OrthoDB" id="436852at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048188">
        <property type="term" value="C:Set1C/COMPASS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16039">
        <property type="entry name" value="PHD_SPP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1210">
        <property type="entry name" value="MAGE homology domain, winged helix WH2 motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041899">
        <property type="entry name" value="MAGE_WH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002190">
        <property type="entry name" value="MHD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037869">
        <property type="entry name" value="Spp1/CFP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46174">
        <property type="entry name" value="CXXC-TYPE ZINC FINGER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46174:SF1">
        <property type="entry name" value="CXXC-TYPE ZINC FINGER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01454">
        <property type="entry name" value="MAGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01373">
        <property type="entry name" value="MAGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="8">
        <location>
            <begin position="603"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="183"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="301"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="375"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="700"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="947"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="330"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="451"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="498"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="519"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="706"/>
            <end position="716"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAG06355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="988" mass="107615" checksum="01BE88DC6B9E2E8C" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CFL2</accession>
    <name>A0A177CFL2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1205349</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG05578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035943.1">
        <property type="nucleotide sequence ID" value="XM_018181969.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CFL2"/>
    <dbReference type="GeneID" id="28765455"/>
    <dbReference type="InParanoid" id="A0A177CFL2"/>
    <dbReference type="OrthoDB" id="3765731at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG05578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="212" mass="23132" checksum="F158971440FAC96F" modified="2016-09-07" version="1">MASSSKSSPSRDQPGSKLSLVTLDLFPSCTRRAPASSFSARTINMLLPEAFGSLVCLSSTPQFVTKFASASTTFLPVAHFSKPIFPSKSIPRTPAIMADFDPIDDGVDDAVENAAALANCWLTHLRDFDCSTTRGGVTEVLAEIISDDSDDLIDYDVVDKAECYTRMLEASSALRDWLKFEHHTKPLIDSGFSKLHLAVNVADFKDTAKKYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CG74</accession>
    <name>A0A177CG74_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CC84DRAFT_1145702</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the RBT5 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG05952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036317.1">
        <property type="nucleotide sequence ID" value="XM_018176522.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CG74"/>
    <dbReference type="STRING" id="1460663.A0A177CG74"/>
    <dbReference type="GeneID" id="28760008"/>
    <dbReference type="InParanoid" id="A0A177CG74"/>
    <dbReference type="OrthoDB" id="408702at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008427">
        <property type="entry name" value="Extracellular_membr_CFEM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF131">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05730">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="12" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="10 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="8 16" id="KW-0732">Signal</keyword>
    <keyword evidence="7 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008058163" evidence="16">
        <location>
            <begin position="22"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="104"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="138"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="180"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="214"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="256"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="293"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="CFEM" evidence="17">
        <location>
            <begin position="32"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="18">
        <location>
            <begin position="122"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="375"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="429"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="375"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF05730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="OAG05952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="545" mass="60349" checksum="D363E4F0B297E819" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CG93</accession>
    <name>A0A177CG93_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pre-mRNA-splicing factor CWC2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Pre-mRNA-splicing factor cwc2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">CC84DRAFT_1164186</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Involved in the first step of pre-mRNA splicing. Required for cell growth and cell cycle control. Plays a role in the levels of the U1, U4, U5 and U6 snRNAs and the maintenance of the U4/U6 snRNA complex. May provide the link between the 'nineteen complex' NTC spliceosome protein complex and the spliceosome through the U6 snRNA. Associates predominantly with U6 snRNAs in assembled active spliceosomes. Binds directly to the internal stem-loop (ISL) domain of the U6 snRNA and to the pre-mRNA intron near the 5' splice site during the activation and catalytic phases of the spliceosome cycle.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRM CWC2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG05717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036082.1">
        <property type="nucleotide sequence ID" value="XM_018178437.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CG93"/>
    <dbReference type="FunCoup" id="A0A177CG93">
        <property type="interactions" value="164"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CG93"/>
    <dbReference type="GeneID" id="28761923"/>
    <dbReference type="InParanoid" id="A0A177CG93"/>
    <dbReference type="OrthoDB" id="10251848at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071006">
        <property type="term" value="C:U2-type catalytic step 1 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071007">
        <property type="term" value="C:U2-type catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036002">
        <property type="term" value="F:pre-mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017070">
        <property type="term" value="F:U6 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12360">
        <property type="entry name" value="RRM_cwf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000249">
        <property type="entry name" value="Pre-mRNA-splicing factor CWC2, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039171">
        <property type="entry name" value="Cwc2/Slt11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034181">
        <property type="entry name" value="Cwc2_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032297">
        <property type="entry name" value="Torus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14089:SF2">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR CWC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14089">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR RBM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16131">
        <property type="entry name" value="Torus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="10" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 15" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="8 16" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 16" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="19">
        <location>
            <begin position="124"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="18">
        <location>
            <begin position="187"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="16">
        <location>
            <begin position="124"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="390"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="17">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="19"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00025224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00072313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="OAG05717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="414" mass="45691" checksum="F00BC0E6500F31AA" modified="2016-09-07" version="1">MTEVQSPPPTLAPPAEEQPSLTADEPSTSTSLVPASTTDQVIITTNAEGKRVKKIIRRKRRPARPQVDAATFKTDAPPPTGTIFNIWYNKWSGGDREDKYLSQTAAQGRCNVAKDSGYTKADKTPGSYFCLFFARGICPKGVDCEYLHRLPTVTDLFPSNVDCFGRDKFSDYRDDMGGVGSFQRQNRTLYIGRIHVTDDIEEIVARHFQEWGQVERVRVLTARGVAFVTYMNEANSQFAKEAMAHQSLDHSEILNVRWATTDPNPAAQKREARRIEEQAAEAIRKALPAAYVAELEGRDNGEAKKRRKIEGTFGLQGYEAPDEVWFAKEKAEWEQTKELGAPDELLMIEGDTAQDEQEIPMPTQQEPPAPQISGILSGSTLAALKGYTANTSAKKPAPAASGLLVGYGSDDDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CGF1</accession>
    <name>A0A177CGF1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">WD40 repeat-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CC84DRAFT_1164326</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG05908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036273.1">
        <property type="nucleotide sequence ID" value="XM_018178464.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CGF1"/>
    <dbReference type="STRING" id="1460663.A0A177CGF1"/>
    <dbReference type="GeneID" id="28761950"/>
    <dbReference type="InParanoid" id="A0A177CGF1"/>
    <dbReference type="OrthoDB" id="1068471at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052234">
        <property type="entry name" value="U5_snRNP_Component"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44006">
        <property type="entry name" value="U5 SMALL NUCLEAR RIBONUCLEOPROTEIN 40 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44006:SF1">
        <property type="entry name" value="U5 SMALL NUCLEAR RIBONUCLEOPROTEIN 40 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="62"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="105"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="147"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="196"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="231"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="281"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="323"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAG05908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="359" mass="38588" checksum="10921F5AC1EB84A4" modified="2016-09-07" version="1">MSAEKRPAADSFGSTQLVKRAKPDAKTNGSSAVTVANGSAQNGALMHAVPRGGVLQSPVMELTGHSGEVFAARFDPTGQIIASGSMDRSILLWRSSGDCDNYGILTGHKQAVLDLHWSRDSRVLFSASADMHLASWDVETGERIRRHPGHEEVINCMDVSKRGEEVLVSGSDDGYIGLWDTRTKDAVSFIPTEFPITAIALSEAGNELFTGGIDNDIKVWDLRKKAVTYSLLGHADTVTSLQLSPDNTLLLSNAHDSTVRTWDVRPFAPADRAVKTYDGAPTGQERNLLKASWDAEGKRIAAGSGDQSVAIWDAGTGKLLHKLPGHKGAVNDVRFHPRDEPLLVSASSDRTLLVGELAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CGI8</accession>
    <name>A0A177CGI8_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CC84DRAFT_1187053</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG05969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036334.1">
        <property type="nucleotide sequence ID" value="XM_018180900.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CGI8"/>
    <dbReference type="STRING" id="1460663.A0A177CGI8"/>
    <dbReference type="ESTHER" id="9pleo-a0a177cgi8">
        <property type="family name" value="Fungal_carboxylesterase_lipase"/>
    </dbReference>
    <dbReference type="GeneID" id="28764386"/>
    <dbReference type="InParanoid" id="A0A177CGI8"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007948954" description="Carboxylic ester hydrolase" evidence="3">
        <location>
            <begin position="17"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="5">
        <location>
            <begin position="22"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="477"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="478"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="501"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAG05969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="513" mass="54484" checksum="C0F1DE1FFF22F2EB" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CHD1</accession>
    <name>A0A177CHD1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1163259</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG06985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037350.1">
        <property type="nucleotide sequence ID" value="XM_018178217.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CHD1"/>
    <dbReference type="STRING" id="1460663.A0A177CHD1"/>
    <dbReference type="GeneID" id="28761703"/>
    <dbReference type="InParanoid" id="A0A177CHD1"/>
    <dbReference type="OrthoDB" id="5206740at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="73"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="215"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="286"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG06985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="305" mass="32081" checksum="35C884826BD8FF82" modified="2016-09-07" version="1">MAPTLSSRDPPAHIMTTTTTQLPILTPRQPALSQRPSLRLDTQQIRTFGKGSSLRLDTLSAVSPTARNTFSNAYAPPASAAPATGRPSKLRLSIDSSCNAPSSASTPSSASTLSSALTSASTDSSALIIPYKQPHNVRSILSNGPAPRKMASARPLFPAEKRVSFRTPLEEEIKTVKYTLAHSDIASSVSTIASLATTSSEESEETTTLPINTQSASTASLTLSIPSSSSSSSFASLQTSPRPRGPRTGDKRDSSESDSDSCPETPVAGRRKRRRDWRWTLGPLPSDGSASTSASTSEATSEDST</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CHE4</accession>
    <name>A0A177CHE4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">40S ribosomal protein S3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CC84DRAFT_1259505</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the universal ribosomal protein uS3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG06268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036633.1">
        <property type="nucleotide sequence ID" value="XM_018184919.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CHE4"/>
    <dbReference type="FunCoup" id="A0A177CHE4">
        <property type="interactions" value="1107"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CHE4"/>
    <dbReference type="GeneID" id="28768405"/>
    <dbReference type="InParanoid" id="A0A177CHE4"/>
    <dbReference type="OrthoDB" id="10248446at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003906">
        <property type="term" value="F:DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990145">
        <property type="term" value="P:maintenance of translational fidelity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070651">
        <property type="term" value="P:nonfunctional rRNA decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000056">
        <property type="term" value="P:ribosomal small subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd02413">
        <property type="entry name" value="KH-II_40S_S3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1140.32:FF:000004">
        <property type="entry name" value="40S ribosomal protein S3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.20:FF:000006">
        <property type="entry name" value="40S ribosomal protein S3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1140.32">
        <property type="entry name" value="Ribosomal protein S3, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004044">
        <property type="entry name" value="KH_dom_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009019">
        <property type="entry name" value="KH_sf_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036419">
        <property type="entry name" value="Ribosomal_S3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057258">
        <property type="entry name" value="Ribosomal_uS3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001351">
        <property type="entry name" value="Ribosomal_uS3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018280">
        <property type="entry name" value="Ribosomal_uS3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005703">
        <property type="entry name" value="Ribosomal_uS3_euk/arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003219">
        <property type="entry name" value="PRK04191.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01008">
        <property type="entry name" value="uS3_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11760">
        <property type="entry name" value="30S/40S RIBOSOMAL PROTEIN S3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11760:SF32">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07650">
        <property type="entry name" value="KH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00189">
        <property type="entry name" value="Ribosomal_S3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54814">
        <property type="entry name" value="Prokaryotic type KH domain (KH-domain type II)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54821">
        <property type="entry name" value="Ribosomal protein S3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50823">
        <property type="entry name" value="KH_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00548">
        <property type="entry name" value="RIBOSOMAL_S3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 7 10" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="KH type-2" evidence="9">
        <location>
            <begin position="24"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="234"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="234"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAG06268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="264" mass="28961" checksum="1AD31D0D719BF462" modified="2016-09-07" version="1">MATAQGQISKRRKFVADGVFYAELNEFFQRELAEEGYSGVEVRVTPTVTDIIIRATHTQEVLGEQGRRIRELTSLIQKRFKFPENSVSLYAAKVQNRGLSAVAQCESLRYKLLNGLAVRRACYGVLRFIMESGAKGCEVVVSGKLRAARAKSMKFTDGFMIHSGQPAKDFIDEATRHVLLRQGVLGIKVKIMRGADPEGKAGPAKSLPDSVTIIEPKEEQPVVQPMSQDYGAKAIAAQQAAEAQRQAEQGEGEAAPAESYAEEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CHE7</accession>
    <name>A0A177CHE7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Flavin-binding monooxygenase-like protein-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_1196327</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG06210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036575.1">
        <property type="nucleotide sequence ID" value="XM_018181451.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CHE7"/>
    <dbReference type="GeneID" id="28764937"/>
    <dbReference type="InParanoid" id="A0A177CHE7"/>
    <dbReference type="OrthoDB" id="2915840at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050346">
        <property type="entry name" value="FMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23023">
        <property type="entry name" value="DIMETHYLANILINE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13738">
        <property type="entry name" value="Pyr_redox_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAG06210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="581" mass="65157" checksum="0466AD6DA54347C4" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CHV1</accession>
    <name>A0A177CHV1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1164793</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG06542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036907.1">
        <property type="nucleotide sequence ID" value="XM_018178563.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CHV1"/>
    <dbReference type="GeneID" id="28762049"/>
    <dbReference type="InParanoid" id="A0A177CHV1"/>
    <dbReference type="OrthoDB" id="10481529at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008058317" evidence="1">
        <location>
            <begin position="21"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG06542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="78" mass="8453" checksum="4E6A1DAC3156F7CF" modified="2016-09-07" version="1">MKLALSISLVAAALSFEAVALPNKYSEPHPFFDKRGMPARFEVTSHETINGVKSTTVQNKNMSALYGISQAPLLMTAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CI14</accession>
    <name>A0A177CI14_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRM61</fullName>
            <ecNumber evidence="1">2.1.1.220</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">tRNA(m1A58)-methyltransferase subunit TRM61</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CC84DRAFT_1195289</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.1.1.220" evidence="1"/>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG06901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037266.1">
        <property type="nucleotide sequence ID" value="XM_018181398.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CI14"/>
    <dbReference type="STRING" id="1460663.A0A177CI14"/>
    <dbReference type="GeneID" id="28764884"/>
    <dbReference type="InParanoid" id="A0A177CI14"/>
    <dbReference type="OrthoDB" id="5585464at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031515">
        <property type="term" value="C:tRNA (m1A) methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160107">
        <property type="term" value="F:tRNA (adenine(58)-N1)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.330.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014816">
        <property type="entry name" value="tRNA_MeTrfase_Gcd14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12133">
        <property type="entry name" value="TRNA (ADENINE(58)-N(1))-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12133:SF1">
        <property type="entry name" value="TRNA (ADENINE(58)-N(1))-METHYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14801">
        <property type="entry name" value="TrmI-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51620">
        <property type="entry name" value="SAM_TRM61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="343"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00033309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAG06901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="428" mass="47034" checksum="4B71BFFA7E9870E7" modified="2016-09-07" version="1">MRCSGLIARTSAQLHLHSIKRSFATSSFLRRAFQDGDVVLLKDKKAASHEGVLVKLQAAKQTHTHRGNLAHADIIGKEPRQLVHSTRGNAYRIHEPTLAEYVRLTPRLVTPIYPSDANLIVSLLDLHVETPSESPNGNSPVEILEAGTGHGALTLHLARAIHAANPRLPKLQNYTSEQEAEDPVYLGESMADLQDANIETWRANRGAIVHTLDISGKHSKHARKIVEGFRHGMYAGSVDFHVGDPASWITEQLKVRKTEDPFLSHVLLDLPGADSYLDVVASALQVNGLLAVFNPSITQIVECVEKIRKDRMPYLLDQVVELGASTIREWDVRAVRPRATLRKAELKDTPDSSSGDEPIDPVKGQEARDNELARDLAKNEEKWAMVCRPKAGLEVVGGGFIALWRKMEPANLSESPEASPAPAATEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CI37</accession>
    <name>A0A177CI37_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1215988</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG06976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037341.1">
        <property type="nucleotide sequence ID" value="XM_018182758.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CI37"/>
    <dbReference type="GeneID" id="28766244"/>
    <dbReference type="InParanoid" id="A0A177CI37"/>
    <dbReference type="OrthoDB" id="3786280at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG06976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="285" mass="30892" checksum="CDCAE18B661F38E7" modified="2016-09-07" version="1">MSHPRRSASQPSHHLSQYHPRPTPTVPETKTLEWHKQNFYNQQQAWRMQTAIEAASSPSGQANRKPPLGLNKPPPVRGMVTDARRTLRVVNADRTSTPTPDPESLRIRLAALRDSDVVAVAPLSTPSSAGSSICRTPLAKTSREEVSSANSAAAGRPARSQPGSPPHAKTAASSIPGQNTGEHAHTSRLPSEVGSPGLLDVPLSVYGFRSTLPAELQPKEPPLRWDDEPAPQIPPIASDAARDLYEDAELMEFMTANKSYLEPFLEMMPVATTIVKGKLDEVVET</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CIE4</accession>
    <name>A0A177CIE4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_1088227</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG06557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036922.1">
        <property type="nucleotide sequence ID" value="XM_018174246.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CIE4"/>
    <dbReference type="GeneID" id="28757732"/>
    <dbReference type="InParanoid" id="A0A177CIE4"/>
    <dbReference type="OrthoDB" id="2496787at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF143">
        <property type="entry name" value="EXTRACELLULAR MEMBRANE PROTEIN CFEM DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="33"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="67"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="115"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="149"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="186"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="3"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAG06557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="286" mass="31823" checksum="1F370534618DEA78" modified="2016-09-07" version="1">MNVPVIVAAHLGFGTDIWGMQQEDITLSLKWLYVAYFMYMIAEALCQLSILAFYLRIMIDPKSRLAVWTLLVLVVCFGVANAFSMVFQCTPIHFFWNGWRGETSGQCIDVRLFGFVRGGIEIFLDLAILTLPLPMLAGLQMSRKKKLQIMSMFCVGFIITIVSCLRLYAFVQFANTQNPTYDNTSGLYWCATESNLFTIVACMPAIRSIFHKGFNKVRGVSTEASGNNYGSSGGLGRGSYLRQGSGRDQKSGSLPFGVISKSVDVDVYRTQRSDSDIELVDGRPPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CJN8</accession>
    <name>A0A177CJN8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1163826</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG07713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038078.1">
        <property type="nucleotide sequence ID" value="XM_018178347.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CJN8"/>
    <dbReference type="GeneID" id="28761833"/>
    <dbReference type="InParanoid" id="A0A177CJN8"/>
    <dbReference type="OrthoDB" id="10582817at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35711:SF1">
        <property type="entry name" value="ECTODERMAL, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35711">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008058284" evidence="2">
        <location>
            <begin position="18"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG07713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="302" mass="33281" checksum="3DFE40BB52E4D95A" modified="2016-09-07" version="1">MLIKNILFLGLAALAAANPLLEDRATSKAVAGSKTGKKGKVDTCDNTSALTTGVTCPRVKFTAAQIQRTVKQAKAMKLKGKKGKGIHFPAKYKHDKEVKIKVKGIKGTKSKTGKRDLDDREDDEDDEDDEDDEDDEDDEDDEDDEDDEDDEEDDEHLDIEAPEDHAHKGQSLVTRTLEARRGRGGGSSRSRPKATKPKTTKPKTTKPKTTKPKTTKPKKEKCKKAAPVKVGPGAWMFPILKTGVWKPGMMPELNYVILDRKYNYVKTAEREPGSAEEFDICVENPKKGGKATKGKTTKGKTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CJX3</accession>
    <name>A0A177CJX3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">DNA-directed RNA polymerase subunit</fullName>
            <ecNumber evidence="15">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CC84DRAFT_1087957</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 15">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the RNA polymerase beta' chain family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="15"/>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG07793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038158.1">
        <property type="nucleotide sequence ID" value="XM_018174228.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A177CJX3">
        <property type="interactions" value="1064"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CJX3"/>
    <dbReference type="GeneID" id="28757714"/>
    <dbReference type="InParanoid" id="A0A177CJX3"/>
    <dbReference type="OrthoDB" id="270392at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140463">
        <property type="term" value="F:chromatin-protein adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003968">
        <property type="term" value="F:RNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0180034">
        <property type="term" value="P:co-transcriptional lncRNA 3' end processing, cleavage and polyadenylation pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030643">
        <property type="term" value="P:intracellular phosphate ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006369">
        <property type="term" value="P:termination of RNA polymerase II transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019985">
        <property type="term" value="P:translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd02584">
        <property type="entry name" value="RNAP_II_Rpb1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02733">
        <property type="entry name" value="RNAP_II_RPB1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.40.20:FF:000019">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.132.30:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.390:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.274.100:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.860.120:FF:000003">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.180">
        <property type="entry name" value="RNA polymerase ii"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.120">
        <property type="entry name" value="RNA polymerase II, clamp domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.100">
        <property type="entry name" value="RNA polymerase Rpb1, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045867">
        <property type="entry name" value="DNA-dir_RpoC_beta_prime"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000722">
        <property type="entry name" value="RNA_pol_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000684">
        <property type="entry name" value="RNA_pol_II_repeat_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006592">
        <property type="entry name" value="RNA_pol_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007080">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007066">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042102">
        <property type="entry name" value="RNA_pol_Rpb1_3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007083">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007081">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007075">
        <property type="entry name" value="RNA_pol_Rpb1_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007073">
        <property type="entry name" value="RNA_pol_Rpb1_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038593">
        <property type="entry name" value="RNA_pol_Rpb1_7_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044893">
        <property type="entry name" value="RNA_pol_Rpb1_clamp_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038120">
        <property type="entry name" value="Rpb1_funnel_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006336">
        <property type="entry name" value="PRK08566.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376:SF37">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04997">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00623">
        <property type="entry name" value="RNA_pol_Rpb1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04983">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05000">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04998">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04992">
        <property type="entry name" value="RNA_pol_Rpb1_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04990">
        <property type="entry name" value="RNA_pol_Rpb1_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05001">
        <property type="entry name" value="RNA_pol_Rpb1_R"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00663">
        <property type="entry name" value="RPOLA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00115">
        <property type="entry name" value="RNA_POL_II_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 15" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 15" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="12 15" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="RNA polymerase N-terminal" evidence="17">
        <location>
            <begin position="234"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1536"/>
            <end position="1726"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="1542"/>
            <end position="1643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="1654"/>
            <end position="1673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="1682"/>
            <end position="1726"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU004279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="OAG07793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="1726" mass="190868" checksum="837086CB8FBB4C6F" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2023-06-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CKC6</accession>
    <name>A0A177CKC6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_525770</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG07984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038349.1">
        <property type="nucleotide sequence ID" value="XM_018186633.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CKC6"/>
    <dbReference type="GeneID" id="28770119"/>
    <dbReference type="InParanoid" id="A0A177CKC6"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG07984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="155" mass="17451" checksum="E55098ED04993A9A" modified="2016-09-07" version="1">MNGINAVWNASKPPCTWARKPPMLMVPSHFDRLSFHVRFALYSTAPTEITNSYFPENIAYFCPVENSYHVSGYLEDSSIAGHVDGVVPYQHICIDMKGFIVNDPSRLARTSDTHTDRVNILYTTGLTALSVSRDMLAGHRPPLPMRWSFEQSSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CL11</accession>
    <name>A0A177CL11_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1203664</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038599.1">
        <property type="nucleotide sequence ID" value="XM_018181845.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CL11"/>
    <dbReference type="STRING" id="1460663.A0A177CL11"/>
    <dbReference type="GeneID" id="28765331"/>
    <dbReference type="InParanoid" id="A0A177CL11"/>
    <dbReference type="OrthoDB" id="3796606at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="415"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="297"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="340"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="372"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="426"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="443"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="470"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="518"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG08234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="747" mass="81742" checksum="69449A7F7C031F4C" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CLS1</accession>
    <name>A0A177CLS1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF602-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1185128</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the rtf2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038556.1">
        <property type="nucleotide sequence ID" value="XM_018180787.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CLS1"/>
    <dbReference type="STRING" id="1460663.A0A177CLS1"/>
    <dbReference type="GeneID" id="28764273"/>
    <dbReference type="InParanoid" id="A0A177CLS1"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006274">
        <property type="term" value="P:DNA replication termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16653">
        <property type="entry name" value="RING-like_Rtf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006735">
        <property type="entry name" value="Rtf2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027799">
        <property type="entry name" value="Rtf2_RING-finger"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12775">
        <property type="entry name" value="PROTEIN C20ORF43 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12775:SF0">
        <property type="entry name" value="REPLICATION TERMINATION FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04641">
        <property type="entry name" value="Rtf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="405"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="664"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="421"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="456"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="668"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="683"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="693"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="726"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="742"/>
            <end position="754"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG08191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="775" mass="85530" checksum="5CA7725E6F501CA0" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CMA8</accession>
    <name>A0A177CMA8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1257260</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038756.1">
        <property type="nucleotide sequence ID" value="XM_018184717.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CMA8"/>
    <dbReference type="STRING" id="1460663.A0A177CMA8"/>
    <dbReference type="GeneID" id="28768203"/>
    <dbReference type="InParanoid" id="A0A177CMA8"/>
    <dbReference type="OrthoDB" id="5404651at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="318"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="370"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="155"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="22"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="47"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="64"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="75"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="340"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="409"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="447"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="474"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="496"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG08391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="510" mass="55821" checksum="DA04759D1BF5CD9F" modified="2016-09-07" version="1">MDSQAPLSQASQESVLIPSTQPSRPATPALPSASRSASPIPKMEKFTSPAPRTTSSMTPPPSSQLPDTRSVVRTPSPPTPGLSSPPPTSKLPNQPSALTESAAALYTPEQVDNASTEELRAMVNDLTGKLRDVRLSAAHHKLQYNMAVMERQESASRMAVELAMAQREIDVLQKAEEKRRNESKPEQTYQESPNVAANAIVMSEMNRQIQLLQNENEELRDLYDQQKRLTEHREGELAGLMEENDRLKSRIRKNRDHIAPYLPYLEQMNESPRSAFGTPHATPRHKLNRVSALSDERSRGQSNFEALLLADKMLSQETATAPSTPARSHGPRSRFGHTRGAQSMSSLPQTPRARAAHVPLEIPRTPTTFSAINIPQSAPPAHYQQESGAVKAAHARRESSNSTITASSVDEEEAYTDREEEVTESQASQLATSMLRRAPSVPKRPSAPSSQSSNLVQSKIFGQVKKGHGLTRSAELDKKRQLSEHHASPTKRGRIDGGGVGLGIGLGLRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CN66</accession>
    <name>A0A177CN66_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">FAD binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CC84DRAFT_574718</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038705.1">
        <property type="nucleotide sequence ID" value="XM_018186726.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CN66"/>
    <dbReference type="STRING" id="1460663.A0A177CN66"/>
    <dbReference type="GeneID" id="28770212"/>
    <dbReference type="InParanoid" id="A0A177CN66"/>
    <dbReference type="OrthoDB" id="47494at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47178:SF1">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47178">
        <property type="entry name" value="MONOOXYGENASE, FAD-BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="8"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAG08340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="417" mass="46204" checksum="E990523C68450DF0" modified="2016-09-07" version="1">MANKIENPVIIIGAGISGLLLAQYLTLAKIPFRIFERRENLGTTNEGWGLTLTWSLPTLRDLLPASLWHRLPEAYVDRAAVERGEASTFPFFDLSTGELKGKTPPAPASRRIRVNREKFRNLLATGIAIEWGKTLSSYESAKDGVTVFFKDGSECSGSLLVGCDGTHSEVRSQLLPDANENYIPIRLMGTKLHMSPIEIEPLRNLDSFFLQATSSKNDTFVYFSVLDAPGNGSSRSYVAQIVVSWPYRKGFLNRDSPLAMPSSNAARLDLLKTFAETWAEPFRSLAFNLPDTAELKPLDLTDWPPAKDVHGNGRAMLVGDALHPMAMYRGDGANHSIQDIQEIAQTIAPLLSGTISESTLRAAIDNYEDEVIARCRPAVLASRQAAFDAHDYRRINPQSPLLSPRVMMIKFDEHDEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CPK6</accession>
    <name>A0A177CPK6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">p-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CC84DRAFT_1255500</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG09455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039820.1">
        <property type="nucleotide sequence ID" value="XM_018184542.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CPK6"/>
    <dbReference type="STRING" id="1460663.A0A177CPK6"/>
    <dbReference type="GeneID" id="28768028"/>
    <dbReference type="InParanoid" id="A0A177CPK6"/>
    <dbReference type="OrthoDB" id="414781at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024156">
        <property type="entry name" value="Small_GTPase_ARF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11711">
        <property type="entry name" value="ADP RIBOSYLATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="43"/>
            <end position="50"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAG09455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="237" mass="26396" checksum="BEFED25E187ED53B" modified="2016-09-07" version="1">MASFFGTITNLFASINPFDTRISTPASRLFARAAPSTLVLLIGLDESGKSTLLREYLSPRPESVHTLITERHIILEELQAGPTTFQAYDIGGCRPDFFWWFEEGLFKRADAVIYLVDAADRDRIMEAREELIMHGLQANNGGMRRGVPLLVLVTKTELENARRPDQIETYFIDNIITSIGDRPTKVAGVNLTTGKGVLDALSWISNTLLNGPQSIVESEKAALTEKSEILRDSRRIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CPL8</accession>
    <name>A0A177CPL8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_1202195</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG09464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039829.1">
        <property type="nucleotide sequence ID" value="XM_018181756.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CPL8"/>
    <dbReference type="FunCoup" id="A0A177CPL8">
        <property type="interactions" value="69"/>
    </dbReference>
    <dbReference type="GeneID" id="28765242"/>
    <dbReference type="InParanoid" id="A0A177CPL8"/>
    <dbReference type="OrthoDB" id="10021397at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF199">
        <property type="entry name" value="MFS EFFLUX TRANSPORTER INPD-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="33"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="71"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="126"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="162"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="193"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="233"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="264"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="301"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="341"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="366"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="430"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="505"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="36"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAG09464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="565" mass="60643" checksum="E64EEB2EB5BD0279" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CQI1</accession>
    <name>A0A177CQI1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_1162917</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG09150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039515.1">
        <property type="nucleotide sequence ID" value="XM_018178125.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CQI1"/>
    <dbReference type="FunCoup" id="A0A177CQI1">
        <property type="interactions" value="33"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CQI1"/>
    <dbReference type="GeneID" id="28761611"/>
    <dbReference type="InParanoid" id="A0A177CQI1"/>
    <dbReference type="OrthoDB" id="6130531at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000193">
        <property type="entry name" value="Ab-hydrolase associated lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006693">
        <property type="entry name" value="AB_hydrolase_lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11005">
        <property type="entry name" value="LYSOSOMAL ACID LIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04083">
        <property type="entry name" value="Abhydro_lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="175"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="Partial AB-hydrolase lipase" evidence="3">
        <location>
            <begin position="266"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="304"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="574"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="720"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="307"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="720"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="751"/>
            <end position="767"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAG09150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="767" mass="86655" checksum="401ADF2F27B3A95B" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CR62</accession>
    <name>A0A177CR62_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1234902</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG09432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039797.1">
        <property type="nucleotide sequence ID" value="XM_018183831.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CR62"/>
    <dbReference type="GeneID" id="28767317"/>
    <dbReference type="InParanoid" id="A0A177CR62"/>
    <dbReference type="OrthoDB" id="10578173at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG09432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="315" mass="34434" checksum="F60330A48F13A5C2" modified="2016-09-07" version="1">MLSLGRGILELARLQPLPCRLPGFERPRRRASSDGRDQRARAHRRRERWQRPSLPFAARQRDAAVRDHIGRPGRRPFCCQDGDPCPGAQAVDVVRRKVRAAVLNRTWQGPDLNAAPDGVLQAEEPASGAGQAVELELEPCRPRWLAYGGLAASSVMQQRESDLARRRITSTGAGELLTTGEPARAPLTPGAAAQSSIVPARALPSLYLFLLAPSFPRTPPSQRQRGLVCAPFAAPDSNSLRGGQSARRLSRASARLHTGHSQVHAATCCIACYKSRHERGWNAVTVLSNALCAAASNRPLRLHECLHRIAPERWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CR83</accession>
    <name>A0A177CR83_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CC84DRAFT_1085102</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040390.1">
        <property type="nucleotide sequence ID" value="XM_018174085.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CR83"/>
    <dbReference type="STRING" id="1460663.A0A177CR83"/>
    <dbReference type="GeneID" id="28757571"/>
    <dbReference type="InParanoid" id="A0A177CR83"/>
    <dbReference type="OrthoDB" id="271725at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000323">
        <property type="entry name" value="RNA binding protein MSSP-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24012">
        <property type="entry name" value="RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="277"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="365"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="169"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="544"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="174"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="545"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="569"/>
            <end position="580"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAG10025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="580" mass="62888" checksum="FD5B0AB64D8FE676" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CRT6</accession>
    <name>A0A177CRT6_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CC84DRAFT_1212914</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion inner membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the complex I NDUFB7 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG09487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039852.1">
        <property type="nucleotide sequence ID" value="XM_018182488.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CRT6"/>
    <dbReference type="STRING" id="1460663.A0A177CRT6"/>
    <dbReference type="GeneID" id="28765974"/>
    <dbReference type="InParanoid" id="A0A177CRT6"/>
    <dbReference type="OrthoDB" id="268414at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008698">
        <property type="entry name" value="NDUB7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20900:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20900">
        <property type="entry name" value="NADH:UBIQUINONE OXIDOREDUCTASE B18-LIKE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05676">
        <property type="entry name" value="NDUF_B7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0249">Electron transport</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <keyword evidence="14" id="KW-0830">Ubiquinone</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OAG09487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="95" mass="11030" checksum="4DA6FA630699D907" modified="2016-09-07" version="1">MTVTDTLKNAVGLSGGEPQKATRDEMSAARLPLAYRDSCAHLLIPLNRCRFDEYYLPWKCEDERHSYEKCQYEEFKLRVKKMDELRAAKNGARSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CRU0</accession>
    <name>A0A177CRU0_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GPN-loop GTPase 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CC84DRAFT_1112366</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Small GTPase required for proper localization of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Binds to RNA polymerase II (RNAPII).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the GPN-loop GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040608.1">
        <property type="nucleotide sequence ID" value="XM_018175314.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CRU0"/>
    <dbReference type="FunCoup" id="A0A177CRU0">
        <property type="interactions" value="1056"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CRU0"/>
    <dbReference type="GeneID" id="28758800"/>
    <dbReference type="InParanoid" id="A0A177CRU0"/>
    <dbReference type="OrthoDB" id="5839at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034087">
        <property type="term" value="P:establishment of mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd17871">
        <property type="entry name" value="GPN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000338">
        <property type="entry name" value="GPN-loop GTPase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004130">
        <property type="entry name" value="Gpn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030231">
        <property type="entry name" value="Gpn2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231:SF3">
        <property type="entry name" value="GPN-LOOP GTPASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231">
        <property type="entry name" value="XPA-BINDING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03029">
        <property type="entry name" value="ATP_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="204"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="319"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="205"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="319"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU365059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAG10243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="393" mass="44276" checksum="E03E1074980737FD" modified="2016-09-07" version="1">MPFAQLVIGPPGSGKSTYCDGMEQFMTAIGRKVSVVNLDPANDHTSYQPDLDVRDLVTIDEIMEQESLGPNGGILYALEELEHNFDWLEKGLKELGDDYILFDCPGQVELFTHHASLRNIFFRLQKIGYRLVVVHLTDSIILSRPSLYVSSLLLALRSMLQMDLPQLNVLTKIDNLRDYGDLPFNLDFYTEVQDLNYLLPHLNREQTSGIPGPSSAQKDGKTDTDMEDDEEPTSKFSALNKAVVELIEDFALVGFETLAVEDKRSMMTLLHAIDRAGGYAFGGVEGANDTVWQMAMRSDGVTMDARDVQERWLDRRDELDEEERRAWAEESKEMKDPPHDIPPAEPTPAAKEVAQPRKTTGVGDDDEDMEDDLEEMRNFIDSKKEGGVKIVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2023-06-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CS22</accession>
    <name>A0A177CS22_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1172754</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040690.1">
        <property type="nucleotide sequence ID" value="XM_018179997.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CS22"/>
    <dbReference type="GeneID" id="28763483"/>
    <dbReference type="InParanoid" id="A0A177CS22"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG10325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="128" mass="13801" checksum="3701EB3208EEEF38" modified="2016-09-07" version="1">MPAVFVCPRLAMNPCTALAIDANIRALNIGPFLSSSSVPAAHGIPHTDSRKQARCRHLPTLSLTTWDPGHTVELSLEHTNLCAADHTIYPPPLTWPAVLGSYATAGMYFTYTNAKMTRPVCGDPSREG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CSE9</accession>
    <name>A0A177CSE9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 7">Arabinan endo-1,5-alpha-L-arabinosidase</fullName>
            <ecNumber evidence="4 7">3.2.1.99</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CC84DRAFT_1139043</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>Endohydrolysis of (1-&gt;5)-alpha-arabinofuranosidic linkages in (1-&gt;5)-arabinans.</text>
            <dbReference type="EC" id="3.2.1.99"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Glycan metabolism; L-arabinan degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the glycosyl hydrolase 43 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.99" evidence="4 7"/>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040829.1">
        <property type="nucleotide sequence ID" value="XM_018176218.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CSE9"/>
    <dbReference type="STRING" id="1460663.A0A177CSE9"/>
    <dbReference type="GeneID" id="28759704"/>
    <dbReference type="InParanoid" id="A0A177CSE9"/>
    <dbReference type="OrthoDB" id="195678at2759"/>
    <dbReference type="UniPathway" id="UPA00667"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046558">
        <property type="term" value="F:arabinan endo-1,5-alpha-L-arabinosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031222">
        <property type="term" value="P:arabinan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd18831">
        <property type="entry name" value="GH43_AnAbnA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050727">
        <property type="entry name" value="GH43_arabinanases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006710">
        <property type="entry name" value="Glyco_hydro_43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016840">
        <property type="entry name" value="Glyco_hydro_43_endo_a_Ara-ase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43301">
        <property type="entry name" value="ARABINAN ENDO-1,5-ALPHA-L-ARABINOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43301:SF3">
        <property type="entry name" value="ARABINAN ENDO-1,5-ALPHA-L-ARABINOSIDASE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04616">
        <property type="entry name" value="Glyco_hydro_43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF026534">
        <property type="entry name" value="Endo_alpha-L-arabinosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008058533" description="Arabinan endo-1,5-alpha-L-arabinosidase" evidence="10">
        <location>
            <begin position="21"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="34"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="200"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate" evidence="9">
        <location>
            <position position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR026534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OAG10464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="321" mass="33998" checksum="DE73F4BD2594068B" modified="2016-09-07" version="1">MKSSIIASLIGLAATVMGYADPMACSGVCNNAHDPALIRRDSDGRYYRFSTGGKIAIHSAKTINGPWTYLRAAIPAGSKINLAGKDDLWAPDVTKFGDTYYLFYSVSSFGSQNSAIGVATSTDLDNWTDHGATGISSKAGSPYNAIDGAAYYDGSNIVMSFGSFWGDIYSVKMNNPPLTVASGATSTRIAYKPSGTHAQEGAFIAKNGNYHYLFFSVGQCCGFDTSKPAAGAEYKIQVCRSTSATGGFVDKSGVSCTNGGGTTVLESHGWVYGPGGQGVYWDPTLGPVLYYHYVDTRIGYADGQKKFGINKIDFSSGWPVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CSF1</accession>
    <name>A0A177CSF1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ATP synthase subunit delta, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">F-ATPase delta subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CC84DRAFT_1081884</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATPase epsilon chain family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040828.1">
        <property type="nucleotide sequence ID" value="XM_018173954.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CSF1"/>
    <dbReference type="FunCoup" id="A0A177CSF1">
        <property type="interactions" value="717"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CSF1"/>
    <dbReference type="GeneID" id="28757440"/>
    <dbReference type="InParanoid" id="A0A177CSF1"/>
    <dbReference type="OrthoDB" id="270171at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12152">
        <property type="entry name" value="F1-ATPase_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.15.10:FF:000003">
        <property type="entry name" value="ATP synthase subunit delta, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.15.10">
        <property type="entry name" value="F0F1 ATP synthase delta/epsilon subunit, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00530">
        <property type="entry name" value="ATP_synth_epsil_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001469">
        <property type="entry name" value="ATP_synth_F1_dsu/esu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020546">
        <property type="entry name" value="ATP_synth_F1_dsu/esu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048938">
        <property type="entry name" value="ATPD_C_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036771">
        <property type="entry name" value="ATPsynth_dsu/esu_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13822">
        <property type="entry name" value="ATP SYNTHASE DELTA/EPSILON CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13822:SF7">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT DELTA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02823">
        <property type="entry name" value="ATP-synt_DE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21334">
        <property type="entry name" value="ATPD_C_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51344">
        <property type="entry name" value="Epsilon subunit of F1F0-ATP synthase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="11" id="KW-0139">CF(1)</keyword>
    <keyword evidence="5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATP synthase F1 complex delta/epsilon subunit N-terminal" evidence="14">
        <location>
            <begin position="36"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="F1F0-ATP synthase subunit delta C-terminal" evidence="15">
        <location>
            <begin position="122"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF21334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OAG10463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="165" mass="17640" checksum="BB9DB1FA231EA955" modified="2016-09-07" version="1">MSSLRIARAALRARPQAIARPVMRRGYADVASDKIKLSLALPHQSIYKSQDVVQVNLPAETGEMGVLANHVPSIEQLKPGLVEIIEESGGSKQFFLSGGFATVQPDSQLSINAVEGYALEDFSAEAVRNQIAEAQKIAGGNGSEQDIAEAKIELEVLESLQAALK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CSN3</accession>
    <name>A0A177CSN3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ARM repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_1160846</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the adaptor complexes large subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG09759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040124.1">
        <property type="nucleotide sequence ID" value="XM_018177597.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CSN3"/>
    <dbReference type="FunCoup" id="A0A177CSN3">
        <property type="interactions" value="450"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CSN3"/>
    <dbReference type="GeneID" id="28761083"/>
    <dbReference type="InParanoid" id="A0A177CSN3"/>
    <dbReference type="OrthoDB" id="10254310at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030123">
        <property type="term" value="C:AP-3 adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026740">
        <property type="entry name" value="AP3_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026739">
        <property type="entry name" value="AP_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11134">
        <property type="entry name" value="ADAPTOR COMPLEX SUBUNIT BETA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037096">
        <property type="entry name" value="AP3_complex_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin/coatomer adaptor adaptin-like N-terminal" evidence="7">
        <location>
            <begin position="41"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="264"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="564"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="709"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="744"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="280"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="583"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="709"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="744"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="789"/>
            <end position="823"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAG09759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="830" mass="91452" checksum="2F4BBD42BF58D2D8" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CSZ4</accession>
    <name>A0A177CSZ4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">FHA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CC84DRAFT_1112681</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the Nibrin family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040781.1">
        <property type="nucleotide sequence ID" value="XM_018175325.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CSZ4"/>
    <dbReference type="STRING" id="1460663.A0A177CSZ4"/>
    <dbReference type="GeneID" id="28758811"/>
    <dbReference type="InParanoid" id="A0A177CSZ4"/>
    <dbReference type="OrthoDB" id="552194at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030870">
        <property type="term" value="C:Mre11 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007095">
        <property type="term" value="P:mitotic G2 DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10980">
        <property type="entry name" value="Nibrin, BRCT2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040227">
        <property type="entry name" value="Nibrin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032429">
        <property type="entry name" value="Nibrin_BRCT2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043014">
        <property type="entry name" value="Nibrin_BRCT2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12162:SF0">
        <property type="entry name" value="NIBRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12162">
        <property type="entry name" value="NIBRIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16508">
        <property type="entry name" value="NIBRIN_BRCT_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="9">
        <location>
            <begin position="23"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="376"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="576"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="685"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="385"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="459"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="498"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="714"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="753"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="820"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAG10416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="820" mass="92498" checksum="54CF738DE4554FFD" modified="2016-09-07" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CUJ9</accession>
    <name>A0A177CUJ9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CC84DRAFT_1237663</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041053.1">
        <property type="nucleotide sequence ID" value="XM_018183907.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CUJ9"/>
    <dbReference type="GeneID" id="28767393"/>
    <dbReference type="InParanoid" id="A0A177CUJ9"/>
    <dbReference type="OrthoDB" id="4161376at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06179">
        <property type="entry name" value="MFS_TRI12_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010573">
        <property type="entry name" value="MFS_Str1/Tri12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053791">
        <property type="entry name" value="MFS_Tri12-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF109">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06609">
        <property type="entry name" value="TRI12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="53"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="121"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="146"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="178"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="211"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="254"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="285"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="323"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="357"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="390"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="414"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="545"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="55"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAG10688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="592" mass="62717" checksum="DDBA67FFC5BD0C73" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CUR4</accession>
    <name>A0A177CUR4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">GPI anchored protein-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CC84DRAFT_1139536</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041123.1">
        <property type="nucleotide sequence ID" value="XM_018176243.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CUR4"/>
    <dbReference type="STRING" id="1460663.A0A177CUR4"/>
    <dbReference type="GeneID" id="28759729"/>
    <dbReference type="InParanoid" id="A0A177CUR4"/>
    <dbReference type="OrthoDB" id="5302720at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.100">
        <property type="entry name" value="Chondroitin AC/alginate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008397">
        <property type="entry name" value="Alginate_lyase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008929">
        <property type="entry name" value="Chondroitin_lyas"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05426">
        <property type="entry name" value="Alginate_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48230">
        <property type="entry name" value="Chondroitin AC/alginate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008058625" evidence="3">
        <location>
            <begin position="19"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="domain" description="Alginate lyase" evidence="4">
        <location>
            <begin position="89"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAG10758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="420" mass="46197" checksum="B9168F7FE9DA2ECA" modified="2016-09-07" version="1">MHFSVLTAIASVAALCSAKAHHASSIHPGPFKVVKFDHPGALHSFADIERIRLRVKNKDEPWYAAYTHLSTSKLAQSTWKATPQTVLVRGPPDPSTNLTQNYGDAYRDAHSAYQLTLRWIVTNNVSFADAAVEILNAWGTTLKSINGSEDRFLAAGLYGYQFANAAELLRIYPGWLKEDQRAFSKMLTSVFASNNHLFLTEHNGKPDFYYANWDLCNIASLMAIGIYSDNSTMYNWAVNLFLNGLPDPSVVVNGALPYFSIANFTEEGSKKTLMEMQESGRDQGHATLCTALLGVIGQQGKNQGLDLYGAFGNQILNSAEYTAKFNTNHSVPYTPYRSWEGILPVVSEKSRFAVRPGFEAIVAHYADTRGLNASWSKAYRDYVNLNITAKVEGGGGDYGPNSGGFDAFGHGTLLYRISGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CUZ7</accession>
    <name>A0A177CUZ7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1256763</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG11066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041431.1">
        <property type="nucleotide sequence ID" value="XM_018184655.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CUZ7"/>
    <dbReference type="STRING" id="1460663.A0A177CUZ7"/>
    <dbReference type="GeneID" id="28768141"/>
    <dbReference type="InParanoid" id="A0A177CUZ7"/>
    <dbReference type="OrthoDB" id="5386330at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG11066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="314" mass="35687" checksum="1D532D2FA9380498" modified="2016-09-07" version="1">MLRAGRSITFAGMHRRERILVDVLSIQPEEGTQALRKEHSQDHMPHAGIHLEHWNSVGAIWKAAITILVLRYLFFGRRELLPAPQSSDSPMKFAQEEQYLQGTNDYLTAGTYFDDPLSRSPSASPIQSPYAPAEPLNFDLWDARYDIHDEAFTTLTSVLATLQPDLDPITLRCVLIPVIILALVSRPDSKERAICVAYFERLDVFVQHSCKSRADSENMNYSIPWDKLDAFSEVAKMQVDPEMESMKGSAPEWNWWDMLKHIDLDLWWPVTAGLSHLESSPEFWTFKLIGGVANEESFKVWMQDTTASSSMPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CV24</accession>
    <name>A0A177CV24_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_492313</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041085.1">
        <property type="nucleotide sequence ID" value="XM_018186506.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CV24"/>
    <dbReference type="STRING" id="1460663.A0A177CV24"/>
    <dbReference type="GeneID" id="28769992"/>
    <dbReference type="InParanoid" id="A0A177CV24"/>
    <dbReference type="OrthoDB" id="4179303at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="401"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="403"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="435"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG10720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="515" mass="58711" checksum="32462003951B0A94" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CVB2</accession>
    <name>A0A177CVB2_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">1,4-alpha-glucan-branching enzyme</fullName>
            <ecNumber evidence="4">2.4.1.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Glycogen-branching enzyme</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CC84DRAFT_1161755</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Glycogen-branching enzyme participates in the glycogen biosynthetic process along with glycogenin and glycogen synthase. Generates alpha-1,6-glucosidic branches from alpha-1,4-linked glucose chains, to increase solubility of the glycogen polymer.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Transfers a segment of a (1-&gt;4)-alpha-D-glucan chain to a primary hydroxy group in a similar glucan chain.</text>
            <dbReference type="EC" id="2.4.1.18"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Glycan biosynthesis; glycogen biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 13 family. GlgB subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.18" evidence="4"/>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041313.1">
        <property type="nucleotide sequence ID" value="XM_018177828.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CVB2"/>
    <dbReference type="FunCoup" id="A0A177CVB2">
        <property type="interactions" value="437"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CVB2"/>
    <dbReference type="GeneID" id="28761314"/>
    <dbReference type="InParanoid" id="A0A177CVB2"/>
    <dbReference type="OrthoDB" id="196493at2759"/>
    <dbReference type="UniPathway" id="UPA00164"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003844">
        <property type="term" value="F:1,4-alpha-glucan branching enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043169">
        <property type="term" value="F:cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd11321">
        <property type="entry name" value="AmyAc_bac_euk_BE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02854">
        <property type="entry name" value="E_set_GBE_euk_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000001">
        <property type="entry name" value="1,4-alpha-glucan branching enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000250">
        <property type="entry name" value="1,4-alpha-glucan-branching enzyme, chloroplastic/amyloplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1180:FF:000003">
        <property type="entry name" value="1,4-alpha-glucan-branching enzyme, chloroplastic/amyloplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006048">
        <property type="entry name" value="A-amylase/branching_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037439">
        <property type="entry name" value="Branching_enzy"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="GH13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004193">
        <property type="entry name" value="Glyco_hydro_13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43651">
        <property type="entry name" value="1,4-ALPHA-GLUCAN-BRANCHING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43651:SF3">
        <property type="entry name" value="1,4-ALPHA-GLUCAN-BRANCHING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02806">
        <property type="entry name" value="Alpha-amylase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02922">
        <property type="entry name" value="CBM_48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000463">
        <property type="entry name" value="GlgB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0320">Glycogen biosynthesis</keyword>
    <keyword evidence="6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyl hydrolase family 13 catalytic" evidence="13">
        <location>
            <begin position="167"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="11">
        <location>
            <position position="355"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="11">
        <location>
            <position position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000463-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OAG10948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="699" mass="79915" checksum="A59ABA1EDC7BA01F" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CVW0</accession>
    <name>A0A177CVW0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1161695</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041224.1">
        <property type="nucleotide sequence ID" value="XM_018177808.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CVW0"/>
    <dbReference type="STRING" id="1460663.A0A177CVW0"/>
    <dbReference type="GeneID" id="28761294"/>
    <dbReference type="InParanoid" id="A0A177CVW0"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG10859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="53" mass="6133" checksum="085D37AA435626EF" modified="2016-09-07" version="1">MWYLKDKIAFPNPKAFDPYRCLTADAHAVSDDRLRNRFYIPFSRGANVSLGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CW14</accession>
    <name>A0A177CW14_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">p-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CC84DRAFT_1113568</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCA family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041284.1">
        <property type="nucleotide sequence ID" value="XM_018175360.1"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CW14"/>
    <dbReference type="GeneID" id="28758846"/>
    <dbReference type="InParanoid" id="A0A177CW14"/>
    <dbReference type="OrthoDB" id="8061355at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005319">
        <property type="term" value="F:lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03263">
        <property type="entry name" value="ABC_subfamily_A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001345">
        <property type="entry name" value="Related to ABC transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026082">
        <property type="entry name" value="ABCA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19229:SF36">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY A MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19229">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER SUBFAMILY A ABCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12698">
        <property type="entry name" value="ABC2_membrane_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="228"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="285"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="318"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="346"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="373"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="423"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="825"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1034"/>
            <end position="1054"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1075"/>
            <end position="1100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1106"/>
            <end position="1130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1142"/>
            <end position="1163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1175"/>
            <end position="1196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1216"/>
            <end position="1239"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="468"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="1281"/>
            <end position="1508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OAG10919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="1599" mass="174871" checksum="C5D10F535FAAFEC4" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CWN0</accession>
    <name>A0A177CWN0_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Small ribosomal subunit protein uS2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">RPS0</name>
        <name evidence="10" type="ORF">CC84DRAFT_1133542</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (25S, 5.8S and 5S). Interacts with RPS21.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6 7">Belongs to the universal ribosomal protein uS2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG11611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041976.1">
        <property type="nucleotide sequence ID" value="XM_018175981.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CWN0"/>
    <dbReference type="FunCoup" id="A0A177CWN0">
        <property type="interactions" value="1222"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CWN0"/>
    <dbReference type="GeneID" id="28759467"/>
    <dbReference type="InParanoid" id="A0A177CWN0"/>
    <dbReference type="OrthoDB" id="414863at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01425">
        <property type="entry name" value="RPS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10490:FF:000010">
        <property type="entry name" value="40S ribosomal protein S0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10490">
        <property type="entry name" value="Glucose-6-phosphate isomerase like protein, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03015">
        <property type="entry name" value="Ribosomal_S2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001865">
        <property type="entry name" value="Ribosomal_uS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032281">
        <property type="entry name" value="Ribosomal_uS2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018130">
        <property type="entry name" value="Ribosomal_uS2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027498">
        <property type="entry name" value="Ribosomal_uS2_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005707">
        <property type="entry name" value="Ribosomal_uS2_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023591">
        <property type="entry name" value="Ribosomal_uS2_flav_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01012">
        <property type="entry name" value="uS2_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11489">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN SA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16122">
        <property type="entry name" value="40S_SA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00318">
        <property type="entry name" value="Ribosomal_S2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00395">
        <property type="entry name" value="RIBOSOMALS2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52313">
        <property type="entry name" value="Ribosomal protein S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00962">
        <property type="entry name" value="RIBOSOMAL_S2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00963">
        <property type="entry name" value="RIBOSOMAL_S2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS2 C-terminal" evidence="9">
        <location>
            <begin position="205"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="215"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="262"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="215"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAG11611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="304" mass="32574" checksum="7249B82FCF91ECA9" modified="2016-09-07" version="1">MAPSNLPAIFNPTSQDIEMLLAAQAHLGSKNLQVHMEPYLWKTRPDGINVINIGKTWEKIVLAARIIAAIDNPADVCVISARPYGQRAVLKFAHHTGAVAIAGRFTPGNFTNYITRSFREPRLIVVTDPRTDAQAIQEASYVNIPVIALCDTDSPTEYVDVAIPTNNKGRHSIGLVWWMLAREVLRLRGTLASRETEWDIMTDLYFYRDPEAEENKDSAGVEEAKVPGADEVGTGPVEAGFTSEWEVSGATAGAAFTSQAAAPAGTSWDADGADWAASGAPAAPAAEGWGAEAPAAEGATNTQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CWP3</accession>
    <name>A0A177CWP3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RNI-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1134200</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG11984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042349.1">
        <property type="nucleotide sequence ID" value="XM_018176013.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CWP3"/>
    <dbReference type="STRING" id="1460663.A0A177CWP3"/>
    <dbReference type="GeneID" id="28759499"/>
    <dbReference type="InParanoid" id="A0A177CWP3"/>
    <dbReference type="OrthoDB" id="550575at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006553">
        <property type="entry name" value="Leu-rich_rpt_Cys-con_subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318:SF190">
        <property type="entry name" value="PARTNER OF PAIRED, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318">
        <property type="entry name" value="PARTNER OF PAIRED, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00367">
        <property type="entry name" value="LRR_CC"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="171"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="675"/>
            <end position="701"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG11984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="701" mass="77320" checksum="517918CF9272BBDC" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CX50</accession>
    <name>A0A177CX50_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CC84DRAFT_1077149</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
            <location evidence="3">PML body</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG11786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042151.1">
        <property type="nucleotide sequence ID" value="XM_018173738.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CX50"/>
    <dbReference type="GeneID" id="28757224"/>
    <dbReference type="InParanoid" id="A0A177CX50"/>
    <dbReference type="OrthoDB" id="9975959at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070260">
        <property type="term" value="F:5'-tyrosyl-DNA phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09080">
        <property type="entry name" value="TDP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051547">
        <property type="entry name" value="TDP2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15822">
        <property type="entry name" value="TRAF AND TNF RECEPTOR-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15822:SF4">
        <property type="entry name" value="TYROSYL-DNA PHOSPHODIESTERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="11">
        <location>
            <begin position="70"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OAG11786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="357" mass="40158" checksum="E01B90F66680F990" modified="2016-09-07" version="1">MSVSKTAPKAILKALQEALTSGPAQQIGDAGYYKPRPQLFHHYNGSTWVSYSPQNYPNGAELPTKNLRIMSWNIDMLIGFAEERMSAALAHLSNLVASTNKEVPVVIFLQEMSQSDMQQIRNAPFIQNYFYITDLDERNWLSPLYGTNTLIDRRLTIKNVFRVPWISKFGRDGLFVDLTLSDQGKGRVLRLCNTHLESLVADPPVRPLQLQAAAPYLHDSSVAAGLLAGDLNAIQPFDRALHSDNDLKDAYLELGGQEDSDDGYTWGYQVPQALREKFGCSRMDKILFSGALRPQKFERIGMGVKVAEEKRQEMRAAGEEEWVTDHYGVMADFHLNDESVLAMTEKREDESPLSKLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CY52</accession>
    <name>A0A177CY52_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glutamine-dependent NAD(+) synthetase</fullName>
            <ecNumber evidence="8">6.3.5.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">NAD(+) synthase [glutamine-hydrolyzing]</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CC84DRAFT_1108206</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>deamido-NAD(+) + L-glutamine + ATP + H2O = L-glutamate + AMP + diphosphate + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24384"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.5.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Cofactor biosynthesis; NAD(+) biosynthesis; NAD(+) from deamido-NAD(+) (L-Gln route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">In the C-terminal section; belongs to the NAD synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.1" evidence="8"/>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042496.1">
        <property type="nucleotide sequence ID" value="XM_018175194.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CY52"/>
    <dbReference type="FunCoup" id="A0A177CY52">
        <property type="interactions" value="741"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CY52"/>
    <dbReference type="GeneID" id="28758680"/>
    <dbReference type="InParanoid" id="A0A177CY52"/>
    <dbReference type="OrthoDB" id="2020662at2759"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00334"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003952">
        <property type="term" value="F:NAD+ synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034354">
        <property type="term" value="P:'de novo' NAD+ biosynthetic process from L-tryptophan"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd07570">
        <property type="entry name" value="GAT_Gln-NAD-synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00553">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000036">
        <property type="entry name" value="Glutamine-dependent NAD(+) synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.110.10:FF:000003">
        <property type="entry name" value="Glutamine-dependent NAD(+) synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02090">
        <property type="entry name" value="NadE_glutamine_dep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014445">
        <property type="entry name" value="Gln-dep_NAD_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022310">
        <property type="entry name" value="NAD/GMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003694">
        <property type="entry name" value="NAD_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00552">
        <property type="entry name" value="nadE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23090:SF9">
        <property type="entry name" value="GLUTAMINE-DEPENDENT NAD(+) SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23090">
        <property type="entry name" value="NH 3 /GLUTAMINE-DEPENDENT NAD + SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02540">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006630">
        <property type="entry name" value="NADS_GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 8" id="KW-0520">NAD</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="9">
        <location>
            <begin position="5"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00052340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR006630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAG12131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="713" mass="80182" checksum="5EBA94069C3D28B4" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CY59</accession>
    <name>A0A177CY59_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1159777</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042838.1">
        <property type="nucleotide sequence ID" value="XM_018177327.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CY59"/>
    <dbReference type="GeneID" id="28760813"/>
    <dbReference type="InParanoid" id="A0A177CY59"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008058737" description="Secreted protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG12473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="88" mass="9580" checksum="0F636EFC2306E222" modified="2016-09-07" version="1">MLSRAGALPWMLSAAPLTLSLHNPAAKFARFSSLKIYPHYLCSLQIPAVHALENMSACRAPSAFDVSSCRDMLVDRLSVASVDSRSCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CZA0</accession>
    <name>A0A177CZA0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1211830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042602.1">
        <property type="nucleotide sequence ID" value="XM_018182405.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CZA0"/>
    <dbReference type="GeneID" id="28765891"/>
    <dbReference type="InParanoid" id="A0A177CZA0"/>
    <dbReference type="OrthoDB" id="5244050at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="463"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="548"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="785"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="246"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="333"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="471"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="497"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="515"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="578"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="627"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="674"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="793"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="809"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="852"/>
            <end position="861"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG12237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="904" mass="98779" checksum="28E07EAD98917D78" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CZV5</accession>
    <name>A0A177CZV5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_1109249</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018043026.1">
        <property type="nucleotide sequence ID" value="XM_018175218.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CZV5"/>
    <dbReference type="GeneID" id="28758704"/>
    <dbReference type="InParanoid" id="A0A177CZV5"/>
    <dbReference type="OrthoDB" id="2250022at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000057">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF23">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="17"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="113"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="148"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="181"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="253"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="285"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="315"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="344"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="376"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="404"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="21"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAG12661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="465" mass="51172" checksum="EBF9593D5B52E3AD" modified="2016-09-07" version="1">MSQEEIAALNKKLVRKIDTIILPIIGILYILNYIDRQNLAAAKLQGIMEDLNMTTQQFATAVSILFVGYLPFQIPSNLLITKFPRPGLYICAAVVIWGGISAATAAVRTYGQLLAVRAVLGVAEAVFFPGAIYYLSAWYTKTELGKRIAALYIAQQFGNAFGGLFAAAILQLDGAHGIRGWQWLFIIEGCATVGIGSICAFFMPEFPHNSRILSQEQRDLAVWRIESESGAAEGTEKESVLKGFAKALSDPKLVLLILCNMLSQAQGSIANFFPTLVASLNFNHTISLLLTAPPYILAGIVYYGLMSWSDRRNTAYPIIMVCISIACGMYIIPMATQNVGARYFAMMILPFASVGPQLVLYKTINLHLARPVAKRAAASALVNAIGGTSNIWASYLYYAPPHFYAAFGTLMGCAFIFAATITTYRWLVLRENKRLDSGRPEEIAKVVKGGVTEEMVRLNWRYEMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177D034</accession>
    <name>A0A177D034_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Glycoside hydrolase/deacetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CC84DRAFT_1072906</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018043271.1">
        <property type="nucleotide sequence ID" value="XM_018173683.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177D034"/>
    <dbReference type="FunCoup" id="A0A177D034">
        <property type="interactions" value="40"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177D034"/>
    <dbReference type="GeneID" id="28757169"/>
    <dbReference type="InParanoid" id="A0A177D034"/>
    <dbReference type="OrthoDB" id="407355at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10951">
        <property type="entry name" value="CE4_ClCDA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11618">
        <property type="entry name" value="ChtBD1_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.10">
        <property type="entry name" value="Endochitinase-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.370">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001002">
        <property type="entry name" value="Chitin-bd_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018371">
        <property type="entry name" value="Chitin-binding_1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036861">
        <property type="entry name" value="Endochitinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46471">
        <property type="entry name" value="CHITIN DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46471:SF8">
        <property type="entry name" value="CHITIN DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00187">
        <property type="entry name" value="Chitin_bind_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00270">
        <property type="entry name" value="ChtBD1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57016">
        <property type="entry name" value="Plant lectins/antimicrobial peptides"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00026">
        <property type="entry name" value="CHIT_BIND_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50941">
        <property type="entry name" value="CHIT_BIND_I_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2 8" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="7" id="KW-0170">Cobalt</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Chitin-binding type-1" evidence="9">
        <location>
            <begin position="68"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="NodB homology" evidence="10">
        <location>
            <begin position="148"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-1" evidence="9">
        <location>
            <begin position="392"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-1" evidence="9">
        <location>
            <begin position="471"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="71"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="80"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="85"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="411"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="474"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="488"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OAG12906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="514" mass="54092" checksum="DB301EBD56C581F5" modified="2016-09-07" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177D0E3</accession>
    <name>A0A177D0E3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1160372</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG13163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018043528.1">
        <property type="nucleotide sequence ID" value="XM_018177482.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177D0E3"/>
    <dbReference type="GeneID" id="28760968"/>
    <dbReference type="InParanoid" id="A0A177D0E3"/>
    <dbReference type="OrthoDB" id="4159814at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG13163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="115" mass="12762" checksum="66E7F622A66BB331" modified="2016-09-07" version="1">MPSPTEPHTILSPISKRDRADNMGYAIPPNAIVLLVLLGTGFVIAMLYGMDRMTGFRGREVPAPRPLSAEQAAYMAEVRRRNAMMLWEEAERGRGKGRRAEKQNLQSSSTAETES</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177D0E7</accession>
    <name>A0A177D0E7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1212468</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018043361.1">
        <property type="nucleotide sequence ID" value="XM_018182457.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177D0E7"/>
    <dbReference type="GeneID" id="28765943"/>
    <dbReference type="InParanoid" id="A0A177D0E7"/>
    <dbReference type="OrthoDB" id="10322091at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008058830" evidence="1">
        <location>
            <begin position="18"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG12996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="162" mass="18234" checksum="898DA25F71C862DE" modified="2016-09-07" version="1">MGSGFDLTLLALVGCVAYRAYEVRRIRQITEAGELKEQILAMGHGRLWPTCPGARFEIITQTAFQQYRSKFFASLVMFTDDGFKIIIKTRTGSGDVLEALEGLLEELAVYVIEHEDEIKKAFDEAVSSKVRRAEGVDDVIPQRKVPYVDRLDGRVIMRCAAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177D0L1</accession>
    <name>A0A177D0L1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">KRR1 small subunit processome component</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">KRR-R motif-containing protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CC84DRAFT_1159942</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Required for 40S ribosome biogenesis. Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the ribosomal small subunit (SSU) processome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
            <location evidence="1 8">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the KRR1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018043035.1">
        <property type="nucleotide sequence ID" value="XM_018177365.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177D0L1"/>
    <dbReference type="FunCoup" id="A0A177D0L1">
        <property type="interactions" value="1066"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177D0L1"/>
    <dbReference type="GeneID" id="28760851"/>
    <dbReference type="InParanoid" id="A0A177D0L1"/>
    <dbReference type="OrthoDB" id="441223at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd22393">
        <property type="entry name" value="KH-I_KRR1_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22394">
        <property type="entry name" value="KH-I_KRR1_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000011">
        <property type="entry name" value="KRR1 small subunit processome component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000014">
        <property type="entry name" value="KRR1 small subunit processome component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041174">
        <property type="entry name" value="KRR1-like_KH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048550">
        <property type="entry name" value="KRR1-like_KH1_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048548">
        <property type="entry name" value="KRR1-like_KH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048549">
        <property type="entry name" value="KRR1-like_KH2_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024166">
        <property type="entry name" value="rRNA_assembly_KRR1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12581">
        <property type="entry name" value="HIV-1 REV BINDING PROTEIN 2, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12581:SF0">
        <property type="entry name" value="KRR1 SMALL SUBUNIT PROCESSOME COMPONENT HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17903">
        <property type="entry name" value="KH_KRR1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21800">
        <property type="entry name" value="KH_KRR1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006515">
        <property type="entry name" value="KRR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 8" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="5 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 8" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="KRR1 small subunit processome component first KH" evidence="10">
        <location>
            <begin position="38"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="KRR1 small subunit processome component second KH" evidence="11">
        <location>
            <begin position="120"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="230"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="273"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="274"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR006515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF17903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF21800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OAG12670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="342" mass="39547" checksum="8DE36A3C1C11D8E3" modified="2016-09-07" version="1">MPSTHNTDKPWDTDDIDKWKIDPFKPEDNAAGAFTEESRFSTLFPKYREQYLRASWKIITAALAKHGVGCELDLTEGSMTVFTTLKTYDPAAILNARDLIKLLARSVPAPQALKILEDDVACDIIKIRNLVTNKDRFVKRRQRILGPNGSTLKALELLTETFILVQGNTVAAMGNWKGLKTVRRIIEDTMANIHPIYSIKELMIKKELEKDPALKNESWDRFLPNFKKRTTAKRRVPHKVTDKTKKTYTPFPPAQEKSKVDLQIESGEYFLGKQAKERKAREDREAKMKEKMDEKRKERLNEYVAPTEDGEKKKKKKRKREDGEEKEKKKKRKDVEVDGETP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177D0L9</accession>
    <name>A0A177D0L9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CC84DRAFT_1160033</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018043142.1">
        <property type="nucleotide sequence ID" value="XM_018177386.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177D0L9"/>
    <dbReference type="STRING" id="1460663.A0A177D0L9"/>
    <dbReference type="GeneID" id="28760872"/>
    <dbReference type="InParanoid" id="A0A177D0L9"/>
    <dbReference type="OrthoDB" id="3437960at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000125">
        <property type="entry name" value="Putative zinc finger protein 143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000614">
        <property type="entry name" value="Zinc finger protein 142"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051061">
        <property type="entry name" value="Zinc_finger_trans_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46179:SF13">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46179">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="506"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="534"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="564"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="593"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="51"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="673"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="673"/>
            <end position="685"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OAG12777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="694" mass="75889" checksum="923D2B0F4C16875E" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177D0P8</accession>
    <name>A0A177D0P8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Lariat debranching enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CC84DRAFT_1212220</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the lariat debranching enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018043075.1">
        <property type="nucleotide sequence ID" value="XM_018182435.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177D0P8"/>
    <dbReference type="FunCoup" id="A0A177D0P8">
        <property type="interactions" value="675"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177D0P8"/>
    <dbReference type="GeneID" id="28765921"/>
    <dbReference type="InParanoid" id="A0A177D0P8"/>
    <dbReference type="OrthoDB" id="407609at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008419">
        <property type="term" value="F:RNA lariat debranching enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00844">
        <property type="entry name" value="MPP_Dbr1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007708">
        <property type="entry name" value="DBR1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041816">
        <property type="entry name" value="Dbr1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12849:SF0">
        <property type="entry name" value="LARIAT DEBRANCHING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12849">
        <property type="entry name" value="RNA LARIAT DEBRANCHING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05011">
        <property type="entry name" value="DBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01124">
        <property type="entry name" value="DBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0464">Manganese</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Lariat debranching enzyme C-terminal" evidence="14">
        <location>
            <begin position="350"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="503"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="523"/>
            <end position="543"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OAG12710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="557" mass="62624" checksum="43F6A12706211993" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177D0S0</accession>
    <name>A0A177D0S0_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">DASH complex subunit DAD3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Outer kinetochore protein DAD3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CC84DRAFT_1078259</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Centromere</location>
            <location evidence="3">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DASH complex DAD3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018043192.1">
        <property type="nucleotide sequence ID" value="XM_018173793.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177D0S0"/>
    <dbReference type="FunCoup" id="A0A177D0S0">
        <property type="interactions" value="5"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177D0S0"/>
    <dbReference type="GeneID" id="28757279"/>
    <dbReference type="InParanoid" id="A0A177D0S0"/>
    <dbReference type="OrthoDB" id="2443965at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042729">
        <property type="term" value="C:DASH complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051010">
        <property type="term" value="F:microtubule plus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008608">
        <property type="term" value="P:attachment of spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013965">
        <property type="entry name" value="DASH_Dad3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28017">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DAD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28017:SF1">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DAD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08656">
        <property type="entry name" value="DASH_Dad3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0132">Cell division</keyword>
    <keyword evidence="15" id="KW-0137">Centromere</keyword>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="10" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="8" id="KW-0493">Microtubule</keyword>
    <keyword evidence="9" id="KW-0498">Mitosis</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00044179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00044305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="OAG12827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="104" mass="11147" checksum="62214D5B662EACB5" modified="2016-09-07" version="1">MATDGPDQALSASQASYLPDAESLTPLEQEVLDEYARLLGNMNNMSALLAELAANPSAEILDALRGLERKTSLVFTLLKASVYSIVLNTQIREEDGGAEGQSMM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177D0T2</accession>
    <name>A0A177D0T2_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Chromosome disjunction protein 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Ribosomal RNA-processing protein 44</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CC84DRAFT_1159897</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
            <location evidence="3">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 16">Belongs to the RNR ribonuclease family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042974.1">
        <property type="nucleotide sequence ID" value="XM_018177358.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177D0T2"/>
    <dbReference type="FunCoup" id="A0A177D0T2">
        <property type="interactions" value="1083"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177D0T2"/>
    <dbReference type="GeneID" id="28760844"/>
    <dbReference type="InParanoid" id="A0A177D0T2"/>
    <dbReference type="OrthoDB" id="372421at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000467">
        <property type="term" value="P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070651">
        <property type="term" value="P:nonfunctional rRNA decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071031">
        <property type="term" value="P:nuclear mRNA surveillance of mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071039">
        <property type="term" value="P:nuclear polyadenylation-dependent CUT catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043628">
        <property type="term" value="P:regulatory ncRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd09862">
        <property type="entry name" value="PIN_Rrp44-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.690:FF:000005">
        <property type="entry name" value="Exosome complex exonuclease dis3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000010">
        <property type="entry name" value="Exosome complex exonuclease DIS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.700:FF:000001">
        <property type="entry name" value="Exosome complex exonuclease exoribonuclease (Rrp44)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.690">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041505">
        <property type="entry name" value="Dis3_CSD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001900">
        <property type="entry name" value="RNase_II/R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022966">
        <property type="entry name" value="RNase_II/R_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050180">
        <property type="entry name" value="RNR_Ribonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033771">
        <property type="entry name" value="Rrp44_CSD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033770">
        <property type="entry name" value="RRP44_S1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23355:SF35">
        <property type="entry name" value="EXOSOME COMPLEX EXONUCLEASE RRP44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23355">
        <property type="entry name" value="RIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17849">
        <property type="entry name" value="OB_Dis3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13638">
        <property type="entry name" value="PIN_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00773">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17216">
        <property type="entry name" value="Rrp44_CSD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17215">
        <property type="entry name" value="Rrp44_S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00670">
        <property type="entry name" value="PINc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00955">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01175">
        <property type="entry name" value="RIBONUCLEASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="11" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="10" id="KW-0271">Exosome</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="PIN" evidence="17">
        <location>
            <begin position="87"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="RNB" evidence="18">
        <location>
            <begin position="523"/>
            <end position="856"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00077930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00081547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU003901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="OAG12609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="990" mass="111818" checksum="D62980B22329ADFB" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177D2C1</accession>
    <name>A0A177D2C1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_184850</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG13169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018043534.1">
        <property type="nucleotide sequence ID" value="XM_018185497.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177D2C1"/>
    <dbReference type="GeneID" id="28768983"/>
    <dbReference type="InParanoid" id="A0A177D2C1"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG13169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="141" mass="16074" checksum="E4479B6F88267719" modified="2016-09-07" version="1">MSRSLLLGVSEVVRRHAVLREYSVCTLYLVFLWGSTSGLACRCWRQMKSAVSRKVWRFVPRRRCVGWNKLAQDDLSGFLDARWLHRSVVFQTDSPAGLCHGRRVHWSIAGGHGRGTSTYQHPSINLSTKSNQMLGMRKTLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BUF0</accession>
    <name>A0A177BUF0_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Anaphase-promoting complex, subunit CDC26</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1169770</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441563">
        <property type="protein sequence ID" value="OAF99072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029438.1">
        <property type="nucleotide sequence ID" value="XM_018179755.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BUF0"/>
    <dbReference type="STRING" id="1460663.A0A177BUF0"/>
    <dbReference type="GeneID" id="28763241"/>
    <dbReference type="InParanoid" id="A0A177BUF0"/>
    <dbReference type="OrthoDB" id="3780941at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018860">
        <property type="entry name" value="APC_suCDC26"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10471">
        <property type="entry name" value="ANAPC_CDC26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="25"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="51"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAF99072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="76" mass="8643" checksum="38A150598E0CF026" modified="2016-09-07" version="1">MLRRPATTITLTSTDLDAYEANRQRKVWEKQQQQAQAAHASNGADTRSERSQQGSVRPQQRSQKDRIMGGQTRHGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BV74</accession>
    <name>A0A177BV74_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GED domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_427957</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441564">
        <property type="protein sequence ID" value="OAF98870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029236.1">
        <property type="nucleotide sequence ID" value="XM_018186193.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BV74"/>
    <dbReference type="STRING" id="1460663.A0A177BV74"/>
    <dbReference type="GeneID" id="28769679"/>
    <dbReference type="InParanoid" id="A0A177BV74"/>
    <dbReference type="OrthoDB" id="415706at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1240">
        <property type="entry name" value="Dynamin, middle domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020850">
        <property type="entry name" value="GED_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51388">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GED" evidence="1">
        <location>
            <begin position="174"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAF98870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="198" mass="22668" checksum="373830B81B0FE090" modified="2016-09-07" version="1">MQGDIDKEFAHSGSNKGDISKWIRNLYHESRGAELPGTINPRVLENMFRQQSEPWRNIATVYIERIGTAIQRFNEAIFAEKISDDELRMKLMAKLSHRHGQTLDKASQQLIIILNDKRGGILQTVNHYFTNTLSAIRKERVLARLEDAGVKDGFAVDLTHILKSIHLSNEDQAINDIHNTLKAYYKVALKRFTDNVVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BVB5</accession>
    <name>A0A177BVB5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_1106027</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441566">
        <property type="protein sequence ID" value="OAF98598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018028964.1">
        <property type="nucleotide sequence ID" value="XM_018175121.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BVB5"/>
    <dbReference type="FunCoup" id="A0A177BVB5">
        <property type="interactions" value="33"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177BVB5"/>
    <dbReference type="GeneID" id="28758607"/>
    <dbReference type="InParanoid" id="A0A177BVB5"/>
    <dbReference type="OrthoDB" id="37537at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19077">
        <property type="entry name" value="AKR_AKR8A1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050791">
        <property type="entry name" value="Aldo-Keto_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43625">
        <property type="entry name" value="AFLATOXIN B1 ALDEHYDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43625:SF78">
        <property type="entry name" value="PYRIDOXAL REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="3">
        <location>
            <begin position="12"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="290"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAF98598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="329" mass="35572" checksum="26CD6CAD48F74935" modified="2016-09-07" version="1">MPTILGKEVGQIGYGLMGLTLRPDPISQEEAFAALKAALKNGMNLWNGGDFYGTLDYNSLVLLERYFEKYPEDADKVVLSIKGAVGPAGHHPDGSPEGIRASVDNCMALLKGRKRIDIFECARRDQNTPLDVTFGVLDKEYVQTGKIGGIGLSEVKASTIIEASKLTKVVAVEAELSLFSMDVLHNGVAAACAELQIPLIAYSPLCRGLLSGRFKSLDDIPEKSLLRLFPRFQPETFPFNVQLANQVGALAKKKGCTLAQLSISWTIAQSRRPGLPTTVPIPGATSVSRIQENSKQVEITDAEVAELEATLDKLKAIGARYPDFVPIEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2023-06-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BVI3</accession>
    <name>A0A177BVI3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1181718</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441563">
        <property type="protein sequence ID" value="OAF98980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029346.1">
        <property type="nucleotide sequence ID" value="XM_018180569.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BVI3"/>
    <dbReference type="GeneID" id="28764055"/>
    <dbReference type="InParanoid" id="A0A177BVI3"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAF98980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="247" mass="27770" checksum="6C4E2B1330B77F55" modified="2016-09-07" version="1">MHLTEAGAPTTTESLRKGIKRAKSASSATISSAPVYFSASCTQRLSVCVQRNVAAHLLQIELRYIVRPREMSAMQCFEDRGVGLELVLIAHRSTASCVTSLSARTCITECVQRNVYLRPTIARASIDRRFGDPQEMLLTRLKGGLAVSLRRSNTAETEGRGWLTACRRPKLDSWRNSYLVDKFVTLYPTLCKGLEGQQRCCIDQRKHRCGTATIPVPQPSTMAFWEWHESRTGRFDRNDSRRGGIFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BW06</accession>
    <name>A0A177BW06_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Metallo-hydrolase/oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CC84DRAFT_1130560</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-beta-lactamase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV441561">
        <property type="protein sequence ID" value="OAF99673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030039.1">
        <property type="nucleotide sequence ID" value="XM_018175864.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BW06"/>
    <dbReference type="STRING" id="1460663.A0A177BW06"/>
    <dbReference type="GeneID" id="28759350"/>
    <dbReference type="InParanoid" id="A0A177BW06"/>
    <dbReference type="OrthoDB" id="10250730at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07730">
        <property type="entry name" value="metallo-hydrolase-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051013">
        <property type="entry name" value="MBL_superfamily_lactonases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42978:SF5">
        <property type="entry name" value="METALLO-BETA-LACTAMASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42978">
        <property type="entry name" value="QUORUM-QUENCHING LACTONASE YTNP-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="5">
        <location>
            <begin position="65"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAF99673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="382" mass="42033" checksum="149AA740FEA4B8F8" modified="2016-09-07" version="1">MASAPKLPWHPIPGSPSGTTCKVHLIQAGGLMIPYDRVFLPGPKQSSHTLSPDYDPSKSEKYYVPDYCFLVEHLPTGDHYIFDLGMRNDLENLPPLIKKDTLPVFTPYPKSPADILKKHGSPDQQPEKVKAVLFSHIHFDHVGDGAKAGFTNAELWVGPTTCTYARPGYPESEGAPVLSENFPTDGSRKIVEAYVSDERLKKDNDSRVGKVVQGKKEGKYEAVELRDVGDGGWIGLGSFDRAFDVFGDGSAYVIDAPGHSPGHQMLLVRVTASARLDTSASSSDKDSFVLLAGDCYHHPDLLKDPERTARPPYSKGSMHADPEVAVETIHRTQAFAHRDNVWVMAAHDFSVGEALRKGEKVIEGLILINDWQGKNWKPDTHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BW37</accession>
    <name>A0A177BW37_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1210353</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441562">
        <property type="protein sequence ID" value="OAF99514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029880.1">
        <property type="nucleotide sequence ID" value="XM_018182286.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BW37"/>
    <dbReference type="GeneID" id="28765772"/>
    <dbReference type="InParanoid" id="A0A177BW37"/>
    <dbReference type="OrthoDB" id="3795090at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="15"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAF99514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="365" mass="41819" checksum="B580A80BD5D8F0EC" modified="2016-09-07" version="1">MTLDDPTSASSRLFSLPELLNSIFLHLPYTDLLHCRAICVLWKHCIDVPLAVRQRMWKAPTKTREGEEPHFEVVSEKAGKVVYTQGNAEWHGRKILEKSQEIRLAFLSEAIPGQEMPTGKYATEMQESRNYAMRSVNFQNEWPDGYCGYVNAAEIVCSLCDRFHTRVRFENLHPILQFLEAYEICFTGVADRLIVEYGDMYCPAWIALRCFGEFGRDMLSFARGLRRAMENAHLHDDLFINPPVTLVAAPETGRAVAATGGLLVRDILLILLELFHYRFKFRAAKTALDLQRAIKNELHIRENNDREAQIAPSQTETALRQKIAKTVVILERFLVTMEDINDILHGVKGWSRVDFCIGKEFDVNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BWE9</accession>
    <name>A0A177BWE9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1169419</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441562">
        <property type="protein sequence ID" value="OAF99280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029646.1">
        <property type="nucleotide sequence ID" value="XM_018179659.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BWE9"/>
    <dbReference type="GeneID" id="28763145"/>
    <dbReference type="InParanoid" id="A0A177BWE9"/>
    <dbReference type="OrthoDB" id="3745836at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAF99280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="211" mass="23673" checksum="648BD7BFCBA9786F" modified="2016-09-07" version="1">MASLDLSRPTLFTPEDLESRPALLDDITGLINDAFTRSKLSEPEKWEGAHRKRFPNHETYLEMLGDEGVVTAIFDDSKIVAVAAAVPWKGGWKKEGADVEDGWEIKAVAVHGNAKYLHRGLAVQLYTSSEQCLVHKERKKLLTTKDVGSTITGHVSLWILAAECINGAYWRKRGYREVRRDTCGPGTWGCLTSFEMVVLQKELTFDLDMSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BWP0</accession>
    <name>A0A177BWP0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1232410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441561">
        <property type="protein sequence ID" value="OAF99822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030188.1">
        <property type="nucleotide sequence ID" value="XM_018183756.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BWP0"/>
    <dbReference type="GeneID" id="28767242"/>
    <dbReference type="InParanoid" id="A0A177BWP0"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAF99822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="379" mass="41255" checksum="1AB30AA2B5D785D1" modified="2016-09-07" version="1">MSLRIPISMRVIYIPGSDFDLFELPMASSVCGTTTFDLAGHEATPGKTRSPSAGIQRIGGPQTPSVAENVDEEYHSRRYVNCCVPLLRDLATTKELQEMSIQLFGSGQGLRHRRPLRKERDTQPHGKMSISSHLLYIYNSLHNVSTTIQMGVPGSANTIVSSLTLWYTPAQNCSNASGLESYGTRMPFHPRTEFEAPVNPEECGDRGDSLMSFSWTSAHCLLTCRYTLLAARRPVLHGGTCWAGEGSVATGSSHNDLTLDEHNRLSTREALEDLYAMGSPAIIQSTRYGTLSPASRTAHHAPIRTTSPMCKVILGGGLQQHHGNLPSTHKTALGSVGFTSCRAAPYASVLATATHADFQPSLATTCTSHCRSKQRARRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BXH7</accession>
    <name>A0A177BXH7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1181289</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441561">
        <property type="protein sequence ID" value="OAF99835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030201.1">
        <property type="nucleotide sequence ID" value="XM_018180543.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BXH7"/>
    <dbReference type="GeneID" id="28764029"/>
    <dbReference type="InParanoid" id="A0A177BXH7"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAF99835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="192" mass="21117" checksum="C904FC880F0D1277" modified="2016-09-07" version="1">MTPESNGPEVDHYSTWHRPLGRPDRVPQYPKPPHFNLAFYQRVTEALRLEQMRQERRFDLYGAVAAESRTSHTPEEVRVTANAGSRAWLCRTTEVYSPSTESTLDPDEELEVHGAGMKRKRGPQSSSPHTLAAPLVSGAGCEPRQPVQTPNQESEDRNPRGVDNAIHEASTGVAPCQNPQTTDGAGPATPRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BXN0</accession>
    <name>A0A177BXN0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">NADPH dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CC84DRAFT_1050164</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KV441560">
        <property type="protein sequence ID" value="OAF99885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030251.1">
        <property type="nucleotide sequence ID" value="XM_018173461.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BXN0"/>
    <dbReference type="STRING" id="1460663.A0A177BXN0"/>
    <dbReference type="GeneID" id="28756947"/>
    <dbReference type="InParanoid" id="A0A177BXN0"/>
    <dbReference type="OrthoDB" id="72788at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003959">
        <property type="term" value="F:NADPH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02932">
        <property type="entry name" value="OYE_YqiM_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044152">
        <property type="entry name" value="YqjM-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43303">
        <property type="entry name" value="NADPH DEHYDROGENASE C23G7.10C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43303:SF4">
        <property type="entry name" value="NADPH DEHYDROGENASE C23G7.10C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:flavin oxidoreductase/NADH oxidase N-terminal" evidence="6">
        <location>
            <begin position="54"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAF99885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="419" mass="45931" checksum="758658631810475D" modified="2016-09-07" version="1" fragment="single">TNTQHAHHGLAKTVEGEDHLVNRPAPGISYFTPLQNPRAGTALGMKDGSEKIPKIFKPLKIRGLQLQNRIFVSPLCQYSADNGHMTDWHLTHIGGIVQRGPGLTFIEASAVVPEGRITPQDVGIWQDSQIEPMRRVVEFAHSQNQRIAIQLAHAGRKASTVAPWLSMGDIATESMGGWPSNVYGPSPIAFNDKHAQPKEMTRQDIESFKAAFKAAIGRSLKAGFDAIEIHNAHGYLLHSFLSPASNHRTDEYGGSFENRIRLTIEVVELARAAIPDTMPLFLRISADDWLQEAGIEGWTIDQTVRLAEILATKGVDVIDVSSAGLHEKQKIKGGPGYQEPFAKAIKDKVGDKLLVSTVGSITNGEQANGYLEKDNLDVVFAGRMFQKNPGLVWAWADDLGVEGRWANQIRWGFGGRGSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BXT1</accession>
    <name>A0A177BXT1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein-serine/threonine kinase</fullName>
            <ecNumber evidence="7">2.7.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CC84DRAFT_1104086</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the PDK/BCKDK protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.-" evidence="7"/>
    <dbReference type="EMBL" id="KV441562">
        <property type="protein sequence ID" value="OAF99511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029877.1">
        <property type="nucleotide sequence ID" value="XM_018175041.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BXT1"/>
    <dbReference type="FunCoup" id="A0A177BXT1">
        <property type="interactions" value="179"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177BXT1"/>
    <dbReference type="GeneID" id="28758527"/>
    <dbReference type="InParanoid" id="A0A177BXT1"/>
    <dbReference type="OrthoDB" id="407390at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004740">
        <property type="term" value="F:pyruvate dehydrogenase (acetyl-transferring) kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010906">
        <property type="term" value="P:regulation of glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.20">
        <property type="entry name" value="Alpha-ketoacid/pyruvate dehydrogenase kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036784">
        <property type="entry name" value="AK/P_DHK_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018955">
        <property type="entry name" value="BCDHK/PDK_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039028">
        <property type="entry name" value="BCKD/PDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11947:SF25">
        <property type="entry name" value="[PYRUVATE DEHYDROGENASE (ACETYL-TRANSFERRING)] KINASE 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11947">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10436">
        <property type="entry name" value="BCDHK_Adom3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69012">
        <property type="entry name" value="alpha-ketoacid dehydrogenase kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Branched-chain alpha-ketoacid dehydrogenase kinase/Pyruvate dehydrogenase kinase N-terminal" evidence="10">
        <location>
            <begin position="54"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase/HSP90-like ATPase" evidence="9">
        <location>
            <begin position="269"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="363"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU366032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF10436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OAF99511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="445" mass="50419" checksum="31C293F38BAC83B3" modified="2016-09-07" version="1">MRAPRCRSLTRAPSHFLCPPGQRRAAHAAAAVAHAPAWRPSSALDEWVQREARPISLRRLTFFGRTLTQSRLLDGANYCRLELPTRIAHRLRDIQTLPYVVVANPHLAHVYELYLTAFERFRRVPEIRSLDDNERYCKILQETLTEHATVIPRLALGVLEVRGLMRPEETDKFMNTMLRSRISRRVIAEQHLALTDTFNSPWHFPHNQPEHDPHVDTVGEIFLKCNAKEIVERCGKTTQELIKAAHGSHVQLPDIHIEGHLDATFPYIQSHLEYIIGELIRNSIQAVIEKKKYHGAKPPPIEVLICETSQHVIIRISDQGGGISNEILPHLWSFSKGPRHQKRLQNLARVPKLLGTLQELKMPGTQASKDHDKHDGGSSLSSLTSRPPDLRLGIGLPMSRVYAEYWAGSLEIHSLEGFGVDAFLQISKLGNKDERLTTRASMDAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BYG7</accession>
    <name>A0A177BYG7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Alpha-glucosidase-like protein maltase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CC84DRAFT_313844</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441559">
        <property type="protein sequence ID" value="OAG00564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030929.1">
        <property type="nucleotide sequence ID" value="XM_018185823.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BYG7"/>
    <dbReference type="FunCoup" id="A0A177BYG7">
        <property type="interactions" value="899"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177BYG7"/>
    <dbReference type="GeneID" id="28769309"/>
    <dbReference type="InParanoid" id="A0A177BYG7"/>
    <dbReference type="OrthoDB" id="1740265at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004556">
        <property type="term" value="F:alpha-amylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033934">
        <property type="term" value="F:glucan 1,4-alpha-maltotriohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004574">
        <property type="term" value="F:oligo-1,6-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004575">
        <property type="term" value="F:sucrose alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000025">
        <property type="term" value="P:maltose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005987">
        <property type="term" value="P:sucrose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11333">
        <property type="entry name" value="AmyAc_SI_OligoGlu_DGase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000064">
        <property type="entry name" value="Oligo-1,6-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.400.10:FF:000004">
        <property type="entry name" value="Oligo-1,6-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000087">
        <property type="entry name" value="Oligo-1,6-glucosidase IMA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1180:FF:000007">
        <property type="entry name" value="Sucrose isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.400.10">
        <property type="entry name" value="Oligo-1,6-glucosidase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="GH13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045857">
        <property type="entry name" value="O16G_dom_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357">
        <property type="entry name" value="ALPHA-AMYLASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357:SF179">
        <property type="entry name" value="NEUTRAL AND BASIC AMINO ACID TRANSPORT PROTEIN RBAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0462">Maltose metabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyl hydrolase family 13 catalytic" evidence="5">
        <location>
            <begin position="16"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00026248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAG00564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="576" mass="65883" checksum="4A1A1265B9AA635C" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BZN3</accession>
    <name>A0A177BZN3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Nitrate reductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">CC84DRAFT_1154402</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 17">Nitrate reductase is a key enzyme involved in the first step of nitrate assimilation in plants, fungi and bacteria.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>nitrite + NADP(+) + H2O = nitrate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19061"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16301"/>
            <dbReference type="ChEBI" id="CHEBI:17632"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.7.1.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="18">
            <name>Mo-molybdopterin</name>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
        </cofactor>
        <text evidence="18">Binds 1 Mo-molybdopterin (Mo-MPT) cofactor per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 17">Belongs to the nitrate reductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441558">
        <property type="protein sequence ID" value="OAG00994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031359.1">
        <property type="nucleotide sequence ID" value="XM_018176886.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BZN3"/>
    <dbReference type="STRING" id="1460663.A0A177BZN3"/>
    <dbReference type="GeneID" id="28760372"/>
    <dbReference type="InParanoid" id="A0A177BZN3"/>
    <dbReference type="OrthoDB" id="432685at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030151">
        <property type="term" value="F:molybdenum ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043546">
        <property type="term" value="F:molybdopterin cofactor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050464">
        <property type="term" value="F:nitrate reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008482">
        <property type="term" value="F:sulfite oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042128">
        <property type="term" value="P:nitrate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006809">
        <property type="term" value="P:nitric oxide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006790">
        <property type="term" value="P:sulfur compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06183">
        <property type="entry name" value="cyt_b5_reduct_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.650:FF:000001">
        <property type="entry name" value="Nitrate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000016">
        <property type="entry name" value="Nitrate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.420.10:FF:000005">
        <property type="entry name" value="Nitrate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.650">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.420.10">
        <property type="entry name" value="Oxidoreductase, molybdopterin-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005066">
        <property type="entry name" value="MoCF_OxRdtse_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008335">
        <property type="entry name" value="Mopterin_OxRdtase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012137">
        <property type="entry name" value="Nitr_rd_NADH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000572">
        <property type="entry name" value="OxRdtase_Mopterin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036374">
        <property type="entry name" value="OxRdtase_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022407">
        <property type="entry name" value="OxRdtase_Mopterin_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19372:SF7">
        <property type="entry name" value="SULFITE OXIDASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19372">
        <property type="entry name" value="SULFITE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03404">
        <property type="entry name" value="Mo-co_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00174">
        <property type="entry name" value="Oxidored_molyb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000233">
        <property type="entry name" value="Nitr_rd_NADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00406">
        <property type="entry name" value="CYTB5RDTASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00363">
        <property type="entry name" value="CYTOCHROMEB5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00407">
        <property type="entry name" value="EUMOPTERIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56524">
        <property type="entry name" value="Oxidoreductase molybdopterin-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00559">
        <property type="entry name" value="MOLYBDOPTERIN_EUK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0274">FAD</keyword>
    <keyword evidence="8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0349">Heme</keyword>
    <keyword evidence="13" id="KW-0408">Iron</keyword>
    <keyword evidence="9 18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 18" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="11" id="KW-0521">NADP</keyword>
    <keyword evidence="14 17" id="KW-0534">Nitrate assimilation</keyword>
    <keyword evidence="12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="20">
        <location>
            <begin position="526"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="21">
        <location>
            <begin position="628"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>Mo-molybdopterin</name>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
        </ligand>
        <ligandPart>
            <name>Mo</name>
            <dbReference type="ChEBI" id="CHEBI:28685"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRNR" id="PIRNR000233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR000233-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="OAG00994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="882" mass="99320" checksum="39F64F25AA4BC5C3" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BZU8</accession>
    <name>A0A177BZU8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Di-copper centre-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CC84DRAFT_1231155</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441560">
        <property type="protein sequence ID" value="OAF99869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030235.1">
        <property type="nucleotide sequence ID" value="XM_018183717.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BZU8"/>
    <dbReference type="STRING" id="1460663.A0A177BZU8"/>
    <dbReference type="GeneID" id="28767203"/>
    <dbReference type="InParanoid" id="A0A177BZU8"/>
    <dbReference type="OrthoDB" id="6132182at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1280.10">
        <property type="entry name" value="Di-copper center containing domain from catechol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008922">
        <property type="entry name" value="Di-copper_centre_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050316">
        <property type="entry name" value="Tyrosinase/Hemocyanin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002227">
        <property type="entry name" value="Tyrosinase_Cu-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474">
        <property type="entry name" value="TYROSINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474:SF126">
        <property type="entry name" value="TYROSINASE-LIKE PROTEIN TYR-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00264">
        <property type="entry name" value="Tyrosinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00092">
        <property type="entry name" value="TYROSINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48056">
        <property type="entry name" value="Di-copper centre-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00498">
        <property type="entry name" value="TYROSINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0186">Copper</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008057591" evidence="3">
        <location>
            <begin position="19"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosinase copper-binding" evidence="4">
        <location>
            <begin position="234"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAF99869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="345" mass="37868" checksum="6FCC40B274F95F15" modified="2016-09-07" version="1">MQSALALLLVVATVGVRAVPFSLVDTPAKCTNPTKRVSWHDVSAEDKKAYISAEQCIMNAEAKLKKMPGAKTQWDELVGLHQILSLQIHSTGTFLPYHRYMLHAHEHLLNQCGYNKGLPYWDETRDAGNFSISPVFDSVLGFGGTGQGTSKCVEDGPFRNFTVNIGPGFTSQPRCVNRQITNALSSYCSASAVQKAISPTTYEEAWRAIYSGPHLMGHIALSMMNADSITSNGDPLFFMHHGFVDKMWADWQAKDPKRLTEISGLNAQDPKVGFLEFPGGIEEESKMWGHPTTEMKAVTPDPTTGDKGGNQTTLGHVMTSLGIIPDTTLENIMDTKGGYLCYEYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C0N1</accession>
    <name>A0A177C0N1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">catechol O-methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CC84DRAFT_1199357</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.6" evidence="1"/>
    <dbReference type="EMBL" id="KV441559">
        <property type="protein sequence ID" value="OAG00449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030814.1">
        <property type="nucleotide sequence ID" value="XM_018181612.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C0N1"/>
    <dbReference type="GeneID" id="28765098"/>
    <dbReference type="InParanoid" id="A0A177C0N1"/>
    <dbReference type="OrthoDB" id="186626at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006584">
        <property type="term" value="P:catecholamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002935">
        <property type="entry name" value="SAM_O-MeTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43836">
        <property type="entry name" value="CATECHOL O-METHYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43836:SF2">
        <property type="entry name" value="CATECHOL O-METHYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01596">
        <property type="entry name" value="Methyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51682">
        <property type="entry name" value="SAM_OMT_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0128">Catecholamine metabolism</keyword>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ATP-grasp" evidence="8">
        <location>
            <begin position="439"/>
            <end position="635"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAG00449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="744" mass="82841" checksum="9875178A6B5C4F04" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C0T2</accession>
    <name>A0A177C0T2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RTA1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CC84DRAFT_191095</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441557">
        <property type="protein sequence ID" value="OAG01404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031769.1">
        <property type="nucleotide sequence ID" value="XM_018185538.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C0T2"/>
    <dbReference type="FunCoup" id="A0A177C0T2">
        <property type="interactions" value="37"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177C0T2"/>
    <dbReference type="GeneID" id="28769024"/>
    <dbReference type="InParanoid" id="A0A177C0T2"/>
    <dbReference type="OrthoDB" id="4521223at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007568">
        <property type="entry name" value="RTA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465:SF8">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G14140)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04479">
        <property type="entry name" value="RTA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="59"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="220"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="260"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAG01404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="310" mass="34023" checksum="9731BF21523B7424" modified="2016-09-07" version="1">MTGPKVQVPQLCESVGPQCPVEGTVYGYYPSLGWNAFFAAAFGLAFILQVGLGIRYKTWTYMIGVGLGCLGELIGYIGRIQLHNNPYDNNGFTIQIVMLIFSPAFLAAGIYLTLKHIVISFGEQWSRLRPNWYTYIFIACDITSLVLQSAGGALAATADDDNQKALDAGTDIMIGGIIFQVVVLAIFAAIVLEYSFRTHRRRDQLSPEAIALWSSTKFRLFAGAIVVAYFGILIRCIYRIPELLGGWANDIMRNEPEFIVLEGVMILVTVVAQTAFHPGWFFPALGGTLFSKKKGAKSVSESETEMSAMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C0T6</accession>
    <name>A0A177C0T6_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1168519</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441559">
        <property type="protein sequence ID" value="OAG00418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030783.1">
        <property type="nucleotide sequence ID" value="XM_018179418.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C0T6"/>
    <dbReference type="STRING" id="1460663.A0A177C0T6"/>
    <dbReference type="GeneID" id="28762904"/>
    <dbReference type="InParanoid" id="A0A177C0T6"/>
    <dbReference type="OrthoDB" id="10256055at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41677:SF1">
        <property type="entry name" value="FE2OG DIOXYGENASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41677">
        <property type="entry name" value="YALI0B19030P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="144"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="287"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG00418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="364" mass="40725" checksum="AF518430B0AD9E20" modified="2016-09-07" version="1">MSDHSADMMATVAVQTTVAPAVARLRAVPKFDPVRHLARAFPEKNVSMQELGFAEDVGVSPVAVSGPFQLFTSEAVNIMRDEIFCVPDKYKFSSNIAKSQLRGYAKDCAPFTWDAWNHPETIALISEIAEVELVPAMPYEIAHINLSSKSKEDAQQELAKYQEHQRRYQEDEGIGGCREVVETPIVGWHTDSYPFVCVLMMSDVRGMVGGETAIRMVNGKVLKMRGPSQGCAVIMQGRYITHQAMRALGAQERITSVTSFRPKSALLKDDTELRTVRGVSDLNELYYDFAEYRLKLLEEQIQHERERVQAARKAGGEFATAQHKQFLGNVTAFSQQSSHELVDQCEVQKGYIEKVDFPDAAIDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C0U3</accession>
    <name>A0A177C0U3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cupredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CC84DRAFT_1129270</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the multicopper oxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441559">
        <property type="protein sequence ID" value="OAG00509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030874.1">
        <property type="nucleotide sequence ID" value="XM_018175826.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C0U3"/>
    <dbReference type="STRING" id="1460663.A0A177C0U3"/>
    <dbReference type="GeneID" id="28759312"/>
    <dbReference type="InParanoid" id="A0A177C0U3"/>
    <dbReference type="OrthoDB" id="262547at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13866">
        <property type="entry name" value="CuRO_2_BOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13889">
        <property type="entry name" value="CuRO_3_BOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48267:SF1">
        <property type="entry name" value="BILIRUBIN OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48267">
        <property type="entry name" value="CUPREDOXIN SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0186">Copper</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008057549" evidence="3">
        <location>
            <begin position="23"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="6">
        <location>
            <begin position="99"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="4">
        <location>
            <begin position="235"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="5">
        <location>
            <begin position="406"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAG00509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="613" mass="68608" checksum="C40BA1DC6DCAB828" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C1E3</accession>
    <name>A0A177C1E3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Concanavalin A-like lectin/glucanase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1208506</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441557">
        <property type="protein sequence ID" value="OAG01315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031680.1">
        <property type="nucleotide sequence ID" value="XM_018182165.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C1E3"/>
    <dbReference type="GeneID" id="28765651"/>
    <dbReference type="InParanoid" id="A0A177C1E3"/>
    <dbReference type="OrthoDB" id="5356630at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008057578" description="Concanavalin A-like lectin/glucanase" evidence="2">
        <location>
            <begin position="18"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="355"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG01315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="409" mass="44038" checksum="0ABF98174E3A87F5" modified="2016-09-07" version="1">MKFTTIFLNALIGLATAAPVEDPSPALLEKRYPPNVLTPLYSHRWSNNVWTPATDSRGNATWGPSDSRGFPTETISTFSITPALVNQKFELHFFSPGGYPPIQAIQLWSNTNVPPSANTIPSTSTNGRNVHLGTFRADATGDAVEIPGNPSGWKSVTFGKTGRSSLADEWLGHTGPGMSLDPHCQSLMQTPGRTIMLMGTRPIGSVKFPQIHSARRDLIRKVRLRDAPNANNLKCHTPHTRRQLECLPPTGPVSRPHNRIPRHLHIKPAQMLIAVVRPDEVIRRRAARAVNVHDGVILRAALVVPKADLDFFADPVGGQAEDMDFGGGGEEVDDAGEFGGVVGWRVSGGLVVDVGPAGGEDAGGPALEKSGGGGGCEGGEAEDEGGEELHCECIWFARWEKSAWDPRRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C1I4</accession>
    <name>A0A177C1I4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">FAD-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CC84DRAFT_1153079</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441557">
        <property type="protein sequence ID" value="OAG01355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031720.1">
        <property type="nucleotide sequence ID" value="XM_018176828.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C1I4"/>
    <dbReference type="STRING" id="1460663.A0A177C1I4"/>
    <dbReference type="GeneID" id="28760314"/>
    <dbReference type="InParanoid" id="A0A177C1I4"/>
    <dbReference type="OrthoDB" id="415825at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="entry name" value="Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016164">
        <property type="entry name" value="FAD-linked_Oxase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF39">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55103">
        <property type="entry name" value="FAD-linked oxidases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="6">
        <location>
            <begin position="41"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAG01355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="470" mass="50972" checksum="4F002777858B7844" modified="2016-09-07" version="1">MAASNVTGLATKLRSTLKNSTVLTPDSEGYAQAIIRWSDEMEKRAGIVVYPETAEDISTAVLLSKEYSVPLAVCGGKHGSSGAASIEGGLQIDMGHMRDVSIDLSNNTAKVQGGCIWKDVDEAAAPHNLAMIGGTINHTGVGGLTLGGGYGWLTGRHGLTIDEVRAVTMVLADGRIVTASSDENQDLFWAVRGAGHCFGIAVDFTFQLHPQENPVWSGQMIFPASKALTTVVNFANNLVATTDGASAMVMGITQPPFMQEPAVVATVFHDGPEDEAREIFKPLLDLNPRINTTKVRPYVEQNSLMNGPVDYGNRKLSKGVPYTLPLSPDFVHSLVGELKKLHAQVDGSTKSIMLFEFFHMGKVLRPWQDMAHAIRGEHNQVMIGPFWLKPEDDATVRSWATNTAAVVRGELERVNGKEVADSIGEYGNYDGLLVDPQRIFGKNLPRLAELKQKYDPENVFNRGYQLVAAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C286</accession>
    <name>A0A177C286_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_218177</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441557">
        <property type="protein sequence ID" value="OAG01763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032128.1">
        <property type="nucleotide sequence ID" value="XM_018185618.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C286"/>
    <dbReference type="STRING" id="1460663.A0A177C286"/>
    <dbReference type="GeneID" id="28769104"/>
    <dbReference type="InParanoid" id="A0A177C286"/>
    <dbReference type="OrthoDB" id="4207123at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42095">
        <property type="entry name" value="YALI0C12166P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42095:SF1">
        <property type="entry name" value="YALI0C12166P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="19"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="40"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG01763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="165" mass="17498" checksum="363E23DB4935AC6E" modified="2016-09-07" version="1">MSTNRPFFSNFLAAFRAQSAIQKAASSQSAAAATTYSHNTSPSPQNANSSASTSRTMTTKAGPPAPGATTAAVQASGQFQPTRQHAAPYHRSTSPATTKAFPIPGASARSRRGSDSSSEGFHEVMGADKWYIGGRTATGEEKFYKLGMVKRHRSVDRLSLDRLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C375</accession>
    <name>A0A177C375_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_280586</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441558">
        <property type="protein sequence ID" value="OAG01227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031592.1">
        <property type="nucleotide sequence ID" value="XM_018185750.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C375"/>
    <dbReference type="GeneID" id="28769236"/>
    <dbReference type="InParanoid" id="A0A177C375"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG01227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="122" mass="14129" checksum="8043C5AC8EFD14B2" modified="2016-09-07" version="1">MFCRCSTARAGLQDRLVCQITIRHDGGCLPQPSHGKTVLPWSTGERKFPLPEEARNLKANKNRLLFQPRFHYSARNWLDGSNFSINSAGILSPCACVFFSYWYHWDRLPRNVRWISSAQLFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C3M8</accession>
    <name>A0A177C3M8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycolipid transfer protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1168373</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441558">
        <property type="protein sequence ID" value="OAG01270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031635.1">
        <property type="nucleotide sequence ID" value="XM_018179381.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C3M8"/>
    <dbReference type="STRING" id="1460663.A0A177C3M8"/>
    <dbReference type="GeneID" id="28762867"/>
    <dbReference type="InParanoid" id="A0A177C3M8"/>
    <dbReference type="OrthoDB" id="205255at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902387">
        <property type="term" value="F:ceramide 1-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902388">
        <property type="term" value="F:ceramide 1-phosphate transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3520.10:FF:000001">
        <property type="entry name" value="Pleckstrin domain-containing family A member 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3520.10">
        <property type="entry name" value="Glycolipid transfer protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036497">
        <property type="entry name" value="GLTP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014830">
        <property type="entry name" value="Glycolipid_transfer_prot_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10219">
        <property type="entry name" value="GLYCOLIPID TRANSFER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10219:SF25">
        <property type="entry name" value="PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY A MEMBER 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08718">
        <property type="entry name" value="GLTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110004">
        <property type="entry name" value="Glycolipid transfer protein, GLTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Glycolipid transfer protein" evidence="2">
        <location>
            <begin position="30"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG01270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="203" mass="22606" checksum="7B28A28C98224CDC" modified="2016-09-07" version="1">MSVTIPPGGTYFDTLRKSFVDVPITADNKISTTEFLEAAESLLTLFDVLGSAAFKPVKNDMSTNIKKIRDRQLAAPTLSDTLQDLVINELKEKKHVATEGLLWLTRGLDFTAQALRHNIANPTKELSDSFRDAYGNTLKPHHSFVIKPIFSAAMSATPYRKDFYAKLGDDESKVQPALESWLAALEKNVGILRTFTTSKEAKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C3N3</accession>
    <name>A0A177C3N3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_1208311</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441556">
        <property type="protein sequence ID" value="OAG02233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032598.1">
        <property type="nucleotide sequence ID" value="XM_018182156.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C3N3"/>
    <dbReference type="STRING" id="1460663.A0A177C3N3"/>
    <dbReference type="GeneID" id="28765642"/>
    <dbReference type="InParanoid" id="A0A177C3N3"/>
    <dbReference type="OrthoDB" id="1560166at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051903">
        <property type="term" value="F:S-(hydroxymethyl)glutathione dehydrogenase [NAD(P)+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046294">
        <property type="term" value="P:formaldehyde catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08278">
        <property type="entry name" value="benzyl_alcohol_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000003">
        <property type="entry name" value="S-(hydroxymethyl)glutathione dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43880">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43880:SF12">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE CLASS-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="7">
        <location>
            <begin position="61"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAG02233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="421" mass="45520" checksum="C5D7DC2BCB7EFAAF" modified="2016-09-07" version="1">MQTVPAAVPEFIRDPKSTIEHVENISLLGNLTRSSENQDVQEKRSDLKNIKTKALVVKEAKADFKMQDVVLDEIRENEVLVEMKYSGICHTDIVVQKGLLPMIEFPAILGHEGAGYIRALGSSVKDKSLRIGDPVLLSFATCGTCTPCRTSHPAYCTTHANVNQNGVRIADRSTPARTTDGTSVRSQYFGQSSFAKMSVVNEMCVVKCDHPDKMDIYAPIGCGFQTGAGTVLNVLKPGKDDSIVVFGLGSVGLTALMAAKYLDVGIIIAVDIVQEKLDMGKDLGATHTVNSRELTDVVEAIKEITKGGAAYAIDCTGIISVIEVMIECLAPLGTAAIVGVPPSGKKISLDPLSFLLENKRLIGVIEGDSDPQKFIPTLVELHSRGHFPIEKLCRTYPVEKVQDAIHDLHAGKVIKPVIEWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C3Y4</accession>
    <name>A0A177C3Y4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">UPF0187-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CC84DRAFT_1179469</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441557">
        <property type="protein sequence ID" value="OAG01380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031745.1">
        <property type="nucleotide sequence ID" value="XM_018180420.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C3Y4"/>
    <dbReference type="STRING" id="1460663.A0A177C3Y4"/>
    <dbReference type="GeneID" id="28763906"/>
    <dbReference type="InParanoid" id="A0A177C3Y4"/>
    <dbReference type="OrthoDB" id="1368at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044669">
        <property type="entry name" value="YneE/VCCN1/2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33281">
        <property type="entry name" value="UPF0187 PROTEIN YNEE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33281:SF19">
        <property type="entry name" value="VOLTAGE-DEPENDENT ANION CHANNEL-FORMING PROTEIN YNEE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25539">
        <property type="entry name" value="Bestrophin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="87"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="115"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="320"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="345"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="455"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="467"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAG01380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="478" mass="54122" checksum="C91A26FE90A32F5C" modified="2016-09-07" version="1">MASSMSTEGSKTLKPGTIEIPTSRGSNDVPMSPRSWRHRTATYQPPSRQHTAASLDAEDYFVGPRDMAKHSKWPFFMRMHGSVLPKMILPLIVVALWSTLITCLCEFVYQLKVSSLLLTVLGFVVGMAISFRTSSAYERYTEGRKYWSQLLLVGQNFSRTVWVHVAERDGELGKEDLLAKISALNLVVAFSRSLLHKLRFEPGIDYPDLKSRVEYLETFAKAAEAEIPKPKKSGKIKAVGESLGVTFAESNPRKRIKRSKRPLGNLPLEILSHMSSYVEYVNQNETLKNGLYHNQLITSIVAFNDVLVGVDRVLNTPLPIAYSIAISQITWVYVLMLPFQMWDDLRWVTIPGSIFAAYIILGIAAIGREIENPFGEDVNDLPLDAFCRELEADIDYIMSNPRPHVAEFFRSPLNKPLGPLSEKSFDSWMGRTKKDIRDALMTKTKAEMRIRASFHVARDQDEDNEKSVQLQHGQQQEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C418</accession>
    <name>A0A177C418_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF453 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1167662</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PrpF family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441557">
        <property type="protein sequence ID" value="OAG01467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031832.1">
        <property type="nucleotide sequence ID" value="XM_018179232.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C418"/>
    <dbReference type="STRING" id="1460663.A0A177C418"/>
    <dbReference type="GeneID" id="28762718"/>
    <dbReference type="InParanoid" id="A0A177C418"/>
    <dbReference type="OrthoDB" id="10267539at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.310.10">
        <property type="entry name" value="Diaminopimelate Epimerase, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007400">
        <property type="entry name" value="PrpF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43709">
        <property type="entry name" value="ACONITATE ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43709:SF2">
        <property type="entry name" value="DUF453 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G00360)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04303">
        <property type="entry name" value="PrpF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54506">
        <property type="entry name" value="Diaminopimelate epimerase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG01467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="399" mass="41797" checksum="A1B628F27A3FDF2C" modified="2016-09-07" version="1">MSSFTICARQTHCASFPRSQTRSFHASSRLRKQQSFPAAYYRGGTSRAVIFKKQDLPSEEKWPSIFRGVINSPDPNGRQLDGIGGGVSSLSKVCVVGPSARDDADVDYTFAAIGVKTSEVDFSSNCGNMSSAIGPFAVNAGLVYMEDGPCTVRIHNTNTGKIIHSKFVVEEGEAKVGGSFAIDGVAGTGAKIELAFINPAGSKTGKTLPTGNVVDTFDNIPVTCIDVGNPCAFVHASSLGVEGGILADAIDAHPDLLSRLDSIRKQAAVAMGISKSLDLVPGSIPKIAMVAAPYTHELISGETVEEKECDLLVRAISVGQPHRAVPITVAMALAVASRLDGSIVKEVTSSRPVDADGITIGHSSGKLLVGANFDKTGAVKDATVFRTARRIMEGVAYAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C496</accession>
    <name>A0A177C496_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Mannose 6-phosphate receptor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CC84DRAFT_1167870</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441557">
        <property type="protein sequence ID" value="OAG01702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032067.1">
        <property type="nucleotide sequence ID" value="XM_018179278.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C496"/>
    <dbReference type="FunCoup" id="A0A177C496">
        <property type="interactions" value="193"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177C496"/>
    <dbReference type="GeneID" id="28762764"/>
    <dbReference type="InParanoid" id="A0A177C496"/>
    <dbReference type="OrthoDB" id="4504960at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.130.10">
        <property type="entry name" value="Mannose-6-phosphate receptor binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028927">
        <property type="entry name" value="Man-6-P_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009011">
        <property type="entry name" value="Man6P_isomerase_rcpt-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044865">
        <property type="entry name" value="MRH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15071:SF0">
        <property type="entry name" value="MANNOSE 6-PHOSPHATE RECEPTOR-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15071">
        <property type="entry name" value="MANNOSE-6-PHOSPHATE RECEPTOR FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02157">
        <property type="entry name" value="Man-6-P_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50911">
        <property type="entry name" value="Mannose 6-phosphate receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51914">
        <property type="entry name" value="MRH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0732">Signal</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008057782" evidence="11">
        <location>
            <begin position="20"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="243"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="MRH" evidence="12">
        <location>
            <begin position="26"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="160"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="164"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OAG01702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="343" mass="37989" checksum="BFFEB925040B66D6" modified="2016-09-07" version="1">MRTSYLAALVALLWTAAAASDKKPPKPCTAVSPTTDRFFDLNPLRREAPEEGKKKKEGEEGSWHARGHDYGANFTINFCGPVVEELDNVQDLDKGLWRNVSAFYERGGKQYALGLESYEPVFRGRKLVLNYTGGSLCPSSSDRRSPHAALDLSAREIIDDDDDDKKKGKDKDDDDTPSKKKPSSDGKRRKTAIISLLCESDPLAKTAFSFVAAVDDCVYFFEGRSSAACGGVHIEEQALGPGGVFGVIMLIAVLVYFVGGCVYQRTVMHQRGWRQLPNYAMWAGIARFVADAFVILTSSCARFLPSRRGYSRVSLGHDRGRGGRGRNDDENRLIDNLDEEWDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C577</accession>
    <name>A0A177C577_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 10">Vacuolar protein 8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CC84DRAFT_912865</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 10">Functions in both vacuole inheritance and protein targeting from the cytoplasm to vacuole.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Vacuole membrane</location>
            <topology evidence="1 10">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the beta-catenin family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG02773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033138.1">
        <property type="nucleotide sequence ID" value="XM_018187884.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C577"/>
    <dbReference type="FunCoup" id="A0A177C577">
        <property type="interactions" value="122"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177C577"/>
    <dbReference type="GeneID" id="28771370"/>
    <dbReference type="InParanoid" id="A0A177C577"/>
    <dbReference type="OrthoDB" id="7537227at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045121">
        <property type="term" value="C:membrane raft"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071563">
        <property type="term" value="C:Myo2p-Vac17p-Vac8p transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071561">
        <property type="term" value="C:nucleus-vacuole junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043495">
        <property type="term" value="F:protein-membrane adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051656">
        <property type="term" value="P:establishment of organelle localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061724">
        <property type="term" value="P:lipophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071562">
        <property type="term" value="P:nucleus-vacuole junction assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000425">
        <property type="term" value="P:pexophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903044">
        <property type="term" value="P:protein localization to membrane raft"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034497">
        <property type="term" value="P:protein localization to phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031503">
        <property type="term" value="P:protein-containing complex localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034517">
        <property type="term" value="P:ribophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042144">
        <property type="term" value="P:vacuole fusion, non-autophagic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000011">
        <property type="term" value="P:vacuole inheritance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000243">
        <property type="entry name" value="Putative Vacuolar protein 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000095">
        <property type="entry name" value="Vacuolar protein 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045156">
        <property type="entry name" value="Vac8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47249">
        <property type="entry name" value="VACUOLAR PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47249:SF1">
        <property type="entry name" value="VACUOLAR PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00514">
        <property type="entry name" value="Arm"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50176">
        <property type="entry name" value="ARM_REPEAT"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 10" id="KW-0926">Vacuole</keyword>
    <feature type="repeat" description="ARM" evidence="9">
        <location>
            <begin position="93"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="9">
        <location>
            <begin position="134"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="9">
        <location>
            <begin position="175"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="9">
        <location>
            <begin position="216"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="9">
        <location>
            <begin position="259"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="9">
        <location>
            <begin position="300"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="9">
        <location>
            <begin position="341"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00026209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU369097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OAG02773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="564" mass="61279" checksum="9979097831EFA330" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C5U4</accession>
    <name>A0A177C5U4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1189419</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441556">
        <property type="protein sequence ID" value="OAG02097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032462.1">
        <property type="nucleotide sequence ID" value="XM_018181050.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C5U4"/>
    <dbReference type="STRING" id="1460663.A0A177C5U4"/>
    <dbReference type="GeneID" id="28764536"/>
    <dbReference type="InParanoid" id="A0A177C5U4"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="376"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="380"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="406"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG02097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="436" mass="49626" checksum="46CA50BF2AC99763" modified="2016-09-07" version="1">MASQTENTDTTYVLDLLCDDDSCSLTTLINDVRFHIIVEPEELRKNSDKTFYYDYLDKISGLREAEQREEEELEIRESQGKTKRARDKDSAVALDDNEEGDDGDQCFGDAVVELRNWILGAFKDIAAVHAPADRTPEESTLHDWYHGPTYFYKLKVSQGCIEPQLLEENKAMTKKIEKLVPRLALPRYIQKMTLPWLNAKDLVVKSETASPEPAHPGEVVTKDGKRLFFKPVDSIQPDSFKREIKHLKQLEELDLDIKVPQLYGLVAFQNSKTEVMGLLLSVIKGATPLTHLFDQSVDPSLRKCWSDKVESYVAQLHEHDIIWGDAKADNFMVDKNDELWIIDFGGSYTEGWVDPELKETIEGDDMGVEKIQNALEDPESNTFDPTNSSTIRPSHARSSSSLFVTEKPRTDSKRKHDGEQNGHDNDTYKKRSLKAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C648</accession>
    <name>A0A177C648_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1208382</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441556">
        <property type="protein sequence ID" value="OAG02352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032717.1">
        <property type="nucleotide sequence ID" value="XM_018182159.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C648"/>
    <dbReference type="GeneID" id="28765645"/>
    <dbReference type="InParanoid" id="A0A177C648"/>
    <dbReference type="OrthoDB" id="3793974at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG02352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="359" mass="38495" checksum="A1B37B45CEEDB44F" modified="2016-09-07" version="1">MDVAAQYNPAMTYPPHVVVVRFKRIRERVEGRKPGKVHVSCHASGCEEGKDTHPQILHLEKTFSTFIPLAMFRENIVLALCAAIASAYALPSSFQATNPCPTDTEMACFDVINSSLCLSQNASRNGTAAQMAACVDYPGGMSDLPGSSKIVFSTVALEAHERPGAKLGFNNEAKILRDVSHTGHSLLAGSGKDWCLKSCLGGDIVLRVLLSVGAHACLEEATRRFKSRVEQGGCGGSASVVYQGISPDNWTITTYAWSDGSFTNIAQRELACGTTNTFLGATGRWYTVTSYYLGDNGRKVASEAPLTNMCAAEDKDCHESHKPDALILADGKNWSHVDVSSDELIELLEIANDATTAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C6B6</accession>
    <name>A0A177C6B6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Necrosis-and ethylene-inducing protein-like protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_1126479</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Necrosis inducing protein (NPP1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441556">
        <property type="protein sequence ID" value="OAG02277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032642.1">
        <property type="nucleotide sequence ID" value="XM_018175745.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C6B6"/>
    <dbReference type="STRING" id="1460663.A0A177C6B6"/>
    <dbReference type="GeneID" id="28759231"/>
    <dbReference type="InParanoid" id="A0A177C6B6"/>
    <dbReference type="OrthoDB" id="89086at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008701">
        <property type="entry name" value="NPP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33657">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G00600)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33657:SF8">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G00600)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05630">
        <property type="entry name" value="NPP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029958">
        <property type="entry name" value="Necrosis-inducing_protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0843">Virulence</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008057767" evidence="3">
        <location>
            <begin position="19"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAG02277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="236" mass="24765" checksum="FF010EC768934567" modified="2016-09-07" version="1">MISPKTLVLGLLAASAAALPTDLSKRAVIAHDAVVGFAQAVPDGTTGTLMLKYKPWLKVFNGCVPFPAVDAAGNTGGGLQTTGGSNSGCSSSPGQVYARAATYNGAFAIMYSWYMPKDSPGPGLGHRHDWENIVVWLSSASTSATVRGVAISAHGDYQKPSPPSLDGTRPKIGYISYYPVNHQLISTTDLGGEQPLIAWESMTAAARTAIENTDFGSATPSFRDSNFQTYLADAFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C6V3</accession>
    <name>A0A177C6V3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1178150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG02508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032873.1">
        <property type="nucleotide sequence ID" value="XM_018180321.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C6V3"/>
    <dbReference type="GeneID" id="28763807"/>
    <dbReference type="InParanoid" id="A0A177C6V3"/>
    <dbReference type="OrthoDB" id="10479389at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="204"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="225"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG02508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="331" mass="37795" checksum="0F4A69121548F353" modified="2016-09-07" version="1">MTTTEFTVSCKRSQDCSRLSRCPVVERTMIPELPRLQPQLQTRNKTLLFTRRNSKTRADAEEKEADPSRQKQRGVKSRGQVEYDEANDAWQKEKTVGLRAQVEDNKTPRKIGPRPLPRKRREPKRAPRPKPLPVLLSLSGIDACPRKGERTRHVPRLADGMAYHEHANTKNTYKVMSTAKAIALVESDENAAPPMATTALQKTLAKTTEKKNISPSRGTHSPGLEPRRRELEKQARRELQTPADIEIEEQITKRTAKMADRLTALTRSNQELWLESQAVLDEFLGYAAYVGDEEDVSDARAKFVRVRKRNIRGETYDWPVAKRVREDGVHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C7J1</accession>
    <name>A0A177C7J1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Isoflavone reductase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CC84DRAFT_1197868</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family. Isoflavone reductase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG02738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033103.1">
        <property type="nucleotide sequence ID" value="XM_018181540.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C7J1"/>
    <dbReference type="STRING" id="1460663.A0A177C7J1"/>
    <dbReference type="GeneID" id="28765026"/>
    <dbReference type="InParanoid" id="A0A177C7J1"/>
    <dbReference type="OrthoDB" id="419598at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051609">
        <property type="entry name" value="NmrA/Isoflavone_reductase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706:SF10">
        <property type="entry name" value="NMRA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706">
        <property type="entry name" value="NMRA-LIKE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-binding" evidence="4">
        <location>
            <begin position="10"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAG02738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="326" mass="34600" checksum="06CEBE85F3D50F05" modified="2016-09-07" version="1">MEIKNIIILGARGNVGTALIAELRKIPDQFTITAVSRTSSTYTAPPGSNIAVKAVDYASLESLTDAFAGQDAVVNCITGGATQYEPSVRIIDAAVAAGVKFFFANEFAGNVGSEQFKRLPEAAAGAKVRVREYLTQLVGEGKIAWTALNGGPFFDMWLMKGPAGFDVKNKQARIYGEGTNPLWWTPLPTIAVAAANILRNPSPALNRGIYICPFAPGALTQNVLLAALETVLDAKFTVTHVDVAAINRAAKAALARGDVKTAMRGFAISNQFYEGDCGNNLEGMTENAMCGVKEIGVEEAIREAVGRYGVEGGVVESMFRVEASEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C8T6</accession>
    <name>A0A177C8T6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1177541</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG03541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033906.1">
        <property type="nucleotide sequence ID" value="XM_018180288.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C8T6"/>
    <dbReference type="GeneID" id="28763774"/>
    <dbReference type="InParanoid" id="A0A177C8T6"/>
    <dbReference type="OrthoDB" id="3780500at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG03541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="217" mass="24780" checksum="FC4210A43FC54F08" modified="2016-09-07" version="1">MSAVPSDRAAQPEATQNPNQSPSSPGDEQPIRPESKYLYLGDHTNAENAYGFRIYRTTYSDDDKWDRFMSYLKTNIERSLGRDEQYKHQLARVDWTVQSSPDLQDASMDQVRDHFIQWIDSGEEQPDNSSRFLAFVVVDGESLDSVTSMLEFLEEENLPLDEDDEEGTAYVKLVSVNEKDGDVPVCIQYLYPRVFSFVHGLGWEHIVPGEGEFSARP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C906</accession>
    <name>A0A177C906_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1166239</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG04133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034498.1">
        <property type="nucleotide sequence ID" value="XM_018178906.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C906"/>
    <dbReference type="GeneID" id="28762392"/>
    <dbReference type="InParanoid" id="A0A177C906"/>
    <dbReference type="OrthoDB" id="10532052at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG04133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="75" mass="8133" checksum="1DEF78C8E6DE4994" modified="2016-09-07" version="1">MALYIGAWQAFDIVLYLYFTGSMLTVDWPFQQKGFVEGSMCFVHEDRGAAIGKLGLAREGSLSARRAVAIAAGCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C9L4</accession>
    <name>A0A177C9L4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_859040</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG03542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033907.1">
        <property type="nucleotide sequence ID" value="XM_018187643.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C9L4"/>
    <dbReference type="STRING" id="1460663.A0A177C9L4"/>
    <dbReference type="GeneID" id="28771129"/>
    <dbReference type="InParanoid" id="A0A177C9L4"/>
    <dbReference type="OrthoDB" id="3437405at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008057907" evidence="2">
        <location>
            <begin position="22"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="119"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG03542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="648" mass="71341" checksum="C624A4793F46627B" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C9R9</accession>
    <name>A0A177C9R9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_1149131</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG03592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033957.1">
        <property type="nucleotide sequence ID" value="XM_018176659.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C9R9"/>
    <dbReference type="GeneID" id="28760145"/>
    <dbReference type="InParanoid" id="A0A177C9R9"/>
    <dbReference type="OrthoDB" id="4139357at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010573">
        <property type="entry name" value="MFS_Str1/Tri12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF109">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06609">
        <property type="entry name" value="TRI12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="54"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="90"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="177"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="211"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="251"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="279"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="322"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="360"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="391"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="416"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="450"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="542"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="54"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAG03592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="594" mass="64434" checksum="6B03F2A2E1EAB08C" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C9X7</accession>
    <name>A0A177C9X7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Branched-chain-amino-acid aminotransferase</fullName>
            <ecNumber evidence="11">2.6.1.42</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CC84DRAFT_1164870</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-isoleucine + 2-oxoglutarate = (S)-3-methyl-2-oxopentanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24801"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:35146"/>
            <dbReference type="ChEBI" id="CHEBI:58045"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-leucine + 2-oxoglutarate = 4-methyl-2-oxopentanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:18321"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:17865"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-valine + 2-oxoglutarate = 3-methyl-2-oxobutanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24813"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57762"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.42" evidence="11"/>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG04385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034750.1">
        <property type="nucleotide sequence ID" value="XM_018178588.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C9X7"/>
    <dbReference type="STRING" id="1460663.A0A177C9X7"/>
    <dbReference type="GeneID" id="28762074"/>
    <dbReference type="InParanoid" id="A0A177C9X7"/>
    <dbReference type="OrthoDB" id="1732691at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052656">
        <property type="term" value="F:L-isoleucine-2-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052654">
        <property type="term" value="F:L-leucine-2-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052655">
        <property type="term" value="F:L-valine-2-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:L-leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:L-valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01557">
        <property type="entry name" value="BCAT_beta_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.10.10:FF:000004">
        <property type="entry name" value="Branched-chain-amino-acid aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.10:FF:000005">
        <property type="entry name" value="Branched-chain-amino-acid aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.10.10">
        <property type="entry name" value="D-amino Acid Aminotransferase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001544">
        <property type="entry name" value="Aminotrans_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018300">
        <property type="entry name" value="Aminotrans_IV_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036038">
        <property type="entry name" value="Aminotransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005786">
        <property type="entry name" value="B_amino_transII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043132">
        <property type="entry name" value="BCAT-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043131">
        <property type="entry name" value="BCAT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033939">
        <property type="entry name" value="BCAT_family"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01123">
        <property type="entry name" value="ilvE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009897">
        <property type="entry name" value="PRK13357.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11825:SF44">
        <property type="entry name" value="BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11825">
        <property type="entry name" value="SUBGROUP IIII AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01063">
        <property type="entry name" value="Aminotran_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006468">
        <property type="entry name" value="BCAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56752">
        <property type="entry name" value="D-aminoacid aminotransferase-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00770">
        <property type="entry name" value="AA_TRANSFER_CLASS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3 11 13" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="7 11" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="6 10" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11 13" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="8"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="8">
        <location>
            <position position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR006468-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OAG04385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="395" mass="43169" checksum="38C2751EB3D235F7" modified="2016-09-07" version="1">MAPGIVSPQRSFEQDSASSGPARLDASKLRVTKTLHPSKLPPAEDLTFGSHHTDHILQVRWTSEHGWQTPQIAPYQHLALDPAAAVLHYGFECFEGMKAYRDAWGSVRLFRPEVNLDRLNRSAARIALPTFDADELLKLIARFVKLEERFIYGKPGYSLYIRPVIIATNSNLGVAAPTSALLYCIACPVGPYFSAGFKAITLEAASSVVATRAWPGGAGNHKIGGNYAPCIAPEKAAKARGFQQLLWLFGDDDRITEAGTMNLFIVLRTEQEGCFELITPPLDGMILPGVTRDCVLSLARERLAPSGWTISEREICMSEVVHAAGVGKLVEVFGTGTAAVVSPIRAIKYRDTLVQCGLSRHQSAGAITALFKEWIEARQYAVEEHPWSVPVSEIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C9Z6</accession>
    <name>A0A177C9Z6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">FAD/NAD(P)-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CC84DRAFT_1260727</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG03598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033963.1">
        <property type="nucleotide sequence ID" value="XM_018185006.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C9Z6"/>
    <dbReference type="STRING" id="1460663.A0A177C9Z6"/>
    <dbReference type="GeneID" id="28768492"/>
    <dbReference type="InParanoid" id="A0A177C9Z6"/>
    <dbReference type="OrthoDB" id="655030at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051704">
        <property type="entry name" value="FAD_aromatic-hydroxylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46865:SF7">
        <property type="entry name" value="MONOOXYGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G07040)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46865">
        <property type="entry name" value="OXIDOREDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="4">
        <location>
            <begin position="4"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAG03598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="431" mass="47159" checksum="BF07430687E28989" modified="2016-09-07" version="1">MPLKILIIGAGVAGPALAFLLQRADPLHHITVIERAPALRATGLQLDFKAQGTPIVRKMGLLEAMRAHRVDETGAEVIGAKGESLARFGIRGDSGTEGLQSGGFTNDLEIMRGDMVKVIVDASVADRKKLEESGVRGGGLRYVFGMNVKGFVQREAEGVDVTFQDGREENFDLVVGADGQNSRTRKMAFGDEISREAFKELGSQVAYFTVPRTESDSTLARIFFAARSRAILLRNGGRPQTQVYLFSQANMEKTKASYGKSVAEQKAVWKETFTGAGWQTERFLEGMQTADDFYAHQLAQVKLPALYKGRIVLVGDAGYCPSVMTGKGTTSAFIGAYVLAGELARQKSNLDAALKSYNEIMKEPVDRAQVISGNVSLPSSSLAVWFIRNGLWAASSLRIDKLLMRLMPQQTDEKELRAWPLPEYPELNLAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CAB8</accession>
    <name>A0A177CAB8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acyl-coenzyme A thioesteras-like protein 13</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_1123161</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioesterase PaaI family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG03718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034083.1">
        <property type="nucleotide sequence ID" value="XM_018175651.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CAB8"/>
    <dbReference type="STRING" id="1460663.A0A177CAB8"/>
    <dbReference type="GeneID" id="28759137"/>
    <dbReference type="InParanoid" id="A0A177CAB8"/>
    <dbReference type="OrthoDB" id="46529at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:fatty acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03443">
        <property type="entry name" value="PaaI_thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.129.10:FF:000033">
        <property type="entry name" value="acyl-coenzyme A thioesterase 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039298">
        <property type="entry name" value="ACOT13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003736">
        <property type="entry name" value="PAAI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00369">
        <property type="entry name" value="unchar_dom_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21660:SF11">
        <property type="entry name" value="FAMILY PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G04355)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21660">
        <property type="entry name" value="THIOESTERASE SUPERFAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioesterase" evidence="3">
        <location>
            <begin position="59"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAG03718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="151" mass="16250" checksum="BA7565B76B4FCF90" modified="2016-09-07" version="1">MAAPANDPELLSFVEQYWAGRLPHSAIYQLVLSDARFTHASKGVVRARVILTKNHVNSHGGIHGSTSATFFDWVGGMAIAAWDKRSKTGVSTDIHVTYQSSAREGDEVEIEGTATKVGGTLAFTKCCIYKVVDGERGAVIAEGSHTKFVKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CAF1</accession>
    <name>A0A177CAF1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1246985</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG04724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035089.1">
        <property type="nucleotide sequence ID" value="XM_018184221.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CAF1"/>
    <dbReference type="GeneID" id="28767707"/>
    <dbReference type="InParanoid" id="A0A177CAF1"/>
    <dbReference type="OrthoDB" id="3794193at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="19"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG04724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="116" mass="12102" checksum="8E7310B7C44DDA5D" modified="2016-09-07" version="1">MSPLAHYIISTSQPRRRSTASLSSTTTTSSMNSDMGLQATTADIGTPKGSSVDLTAQRKQAGEKPSAVSQAQGCMHVCGGGRVEGQQQGLGNGEGKRKGEGRGEWTWNVGFGVWSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CAF2</accession>
    <name>A0A177CAF2_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Twinfilin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CC84DRAFT_1164995</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Actin-binding protein involved in motile and morphological processes. Inhibits actin polymerization, likely by sequestering G-actin.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Interacts with G-actin; ADP-actin form.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cell cortex</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the actin-binding proteins ADF family. Twinfilin subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG04555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034920.1">
        <property type="nucleotide sequence ID" value="XM_018178618.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CAF2"/>
    <dbReference type="FunCoup" id="A0A177CAF2">
        <property type="interactions" value="384"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CAF2"/>
    <dbReference type="GeneID" id="28762104"/>
    <dbReference type="InParanoid" id="A0A177CAF2"/>
    <dbReference type="OrthoDB" id="10006997at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005884">
        <property type="term" value="C:actin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003785">
        <property type="term" value="F:actin monomer binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030042">
        <property type="term" value="P:actin filament depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051016">
        <property type="term" value="P:barbed-end actin filament capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11284">
        <property type="entry name" value="ADF_Twf-C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11285">
        <property type="entry name" value="ADF_Twf-N_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.20.10:FF:000042">
        <property type="entry name" value="Actin depolymerizing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.20.10:FF:000007">
        <property type="entry name" value="Twinfilin-1 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002108">
        <property type="entry name" value="ADF-H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028458">
        <property type="entry name" value="Twinfilin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13759">
        <property type="entry name" value="TWINFILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13759:SF1">
        <property type="entry name" value="TWINFILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00241">
        <property type="entry name" value="Cofilin_ADF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00102">
        <property type="entry name" value="ADF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51263">
        <property type="entry name" value="ADF_H"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ADF-H" evidence="11">
        <location>
            <begin position="3"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="ADF-H" evidence="11">
        <location>
            <begin position="178"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00056419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00069496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OAG04555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="328" mass="35752" checksum="D753B41312B4C38D" modified="2016-09-07" version="1">MQSGISASAELQEALQSLITSTTQRGILATISQEAIVPAAPIPSTHVTFLEDLSNLKDFIKPNEALYILLRRNDVLSSPDKSLVAVTYVPNAAPVRQKMLFAATRLTLVRELGGEHFPESIFCTEADELTAEGWERHLKHTESSNPLTAEEQSLQDIKEAEALESRGTQGQSLAQGGRIAIRADDEISGALRQLAEGGSDNLVQLRMDVPTETLKFVSSSSASADSLASAIDKQEPRFSFYRHSDPDSSVVFISTCPSGAKIRERMLYAASRSNVISLAQNEGGLKVAKRLEATNPDEITAQVIADEFKVEEKEEKKGFAKPKRPGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CAP5</accession>
    <name>A0A177CAP5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Rad4-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CC84DRAFT_1166011</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the XPC family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG03848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034213.1">
        <property type="nucleotide sequence ID" value="XM_018178854.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CAP5"/>
    <dbReference type="STRING" id="1460663.A0A177CAP5"/>
    <dbReference type="GeneID" id="28762340"/>
    <dbReference type="InParanoid" id="A0A177CAP5"/>
    <dbReference type="OrthoDB" id="300780at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000111">
        <property type="term" value="C:nucleotide-excision repair factor 2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071942">
        <property type="term" value="C:XPC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2460:FF:000001">
        <property type="entry name" value="DNA repair protein Rad4 family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.20.110">
        <property type="entry name" value="Rad4, beta-hairpin domain BHD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.290">
        <property type="entry name" value="Rad4, beta-hairpin domain BHD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2460">
        <property type="entry name" value="Rad4, beta-hairpin domain BHD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.260.10">
        <property type="entry name" value="Transglutaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018327">
        <property type="entry name" value="BHD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004583">
        <property type="entry name" value="DNA_repair_Rad4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018325">
        <property type="entry name" value="Rad4/PNGase_transGLS-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018326">
        <property type="entry name" value="Rad4_beta-hairpin_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018328">
        <property type="entry name" value="Rad4_beta-hairpin_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042488">
        <property type="entry name" value="Rad4_BHD3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036985">
        <property type="entry name" value="Transglutaminase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12135:SF2">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12135">
        <property type="entry name" value="DNA REPAIR PROTEIN XP-C / RAD4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10403">
        <property type="entry name" value="BHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10404">
        <property type="entry name" value="BHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10405">
        <property type="entry name" value="BHD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03835">
        <property type="entry name" value="Rad4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01030">
        <property type="entry name" value="BHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01031">
        <property type="entry name" value="BHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01032">
        <property type="entry name" value="BHD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rad4 beta-hairpin" evidence="7">
        <location>
            <begin position="638"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="domain" description="Rad4 beta-hairpin" evidence="8">
        <location>
            <begin position="699"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="domain" description="Rad4 beta-hairpin" evidence="9">
        <location>
            <begin position="769"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="237"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="411"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="462"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="612"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="891"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="976"/>
            <end position="1185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="19"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="89"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="265"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="411"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="421"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="891"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="991"/>
            <end position="1003"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="1014"/>
            <end position="1023"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1042"/>
            <end position="1052"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1173"/>
            <end position="1185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAG03848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="1185" mass="131374" checksum="18FDE0345024801C" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CAS4</accession>
    <name>A0A177CAS4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_875699</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG03942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034307.1">
        <property type="nucleotide sequence ID" value="XM_018187749.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CAS4"/>
    <dbReference type="GeneID" id="28771235"/>
    <dbReference type="InParanoid" id="A0A177CAS4"/>
    <dbReference type="OrthoDB" id="10616930at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG03942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="170" mass="19405" checksum="B589BFE5667C48F0" modified="2016-09-07" version="1">MLLTPAPIGQLPRCVLRNKPQTNRRQRSGERIGALGPRFRALARQQRNDNPTEDLGPAAASRSSRARRHLARSRRARLRRIVSDSSKVSRFTYVHMHAAPTLDRIPVQHRVLLVNNYQTAPYQVSGTRFVTRVDLSLAQRLISRSSRRYFGTLKYVYAWSARCSASSTIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CAZ8</accession>
    <name>A0A177CAZ8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_879235</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG04019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034384.1">
        <property type="nucleotide sequence ID" value="XM_018187769.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CAZ8"/>
    <dbReference type="GeneID" id="28771255"/>
    <dbReference type="InParanoid" id="A0A177CAZ8"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG04019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="161" mass="17955" checksum="F6D8E768F100DBA4" modified="2016-09-07" version="1">MSRKGLIPQARMASFLPPIQEHYSHARPFSAPGPSFLFHPMPSPLTPNSLSDRVCTSPETRSMVTCSQPRPSFLFGSMHSRCRTHPSSLTTPMPVPHLQYLTPSYLTTQSGRSVLAFTVQDFSPSSVRLTCLHRSLLTFRPRTPITVFPLGRKATTQLRCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CB91</accession>
    <name>A0A177CB91_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Ubiquitin-conjugating enzyme E2 2</fullName>
            <ecNumber evidence="2">2.3.2.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">E2 ubiquitin-conjugating enzyme 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">E2 ubiquitin-conjugating enzyme 7</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Ubiquitin carrier protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Ubiquitin carrier protein UBC2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Ubiquitin-protein ligase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Ubiquitin-protein ligase UBC2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CC84DRAFT_1164923</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.</text>
            <dbReference type="EC" id="2.3.2.23"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.23" evidence="2"/>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG04461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034826.1">
        <property type="nucleotide sequence ID" value="XM_018178600.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CB91"/>
    <dbReference type="FunCoup" id="A0A177CB91">
        <property type="interactions" value="794"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CB91"/>
    <dbReference type="GeneID" id="28762086"/>
    <dbReference type="InParanoid" id="A0A177CB91"/>
    <dbReference type="OrthoDB" id="19692at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990389">
        <property type="term" value="C:CUE1-UBC7 ubiquitin-conjugating enzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000837">
        <property type="term" value="C:Doa10p ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000839">
        <property type="term" value="C:Hrd1p ubiquitin ligase ERAD-L complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0180027">
        <property type="term" value="P:inner nuclear membrane-associated protein degradation pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd23796">
        <property type="entry name" value="UBCc_UBE2G2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000008">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 G2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0882">Thioester bond</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 16" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="18">
        <location>
            <begin position="4"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="15">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00039884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00041569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00042179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00042190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00077195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="OAG04461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="165" mass="18824" checksum="96D7261F32FAF8E3" modified="2016-09-07" version="1">MTSQASKRLFKEYRDLSSNPPDGITAGPVTEDDMFVWEALIQGPEDTPFEGGVFPAELKFPKDYPLAPPKMKFLVEMWHPNVYPNGEVCISILHPPGDDPHHYEQASERWSPIQSVEKILISVMSMLAEPNDESPANVDAARMWREKRVEYERIVRDNVRKSLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CBB1</accession>
    <name>A0A177CBB1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1207317</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG04139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034504.1">
        <property type="nucleotide sequence ID" value="XM_018182093.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CBB1"/>
    <dbReference type="GeneID" id="28765579"/>
    <dbReference type="InParanoid" id="A0A177CBB1"/>
    <dbReference type="OrthoDB" id="5396564at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG04139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="295" mass="32907" checksum="28E59BA03FCF1484" modified="2016-09-07" version="1">MSCIVDWTNTTSQANHDKCPICPKRSFIKEELQPSSSGTDRLNRARYNSRHHIVEPRNGYRGNPRYAARAEMISENVELSRPGEREGGAGGHGVQVNPCFIEISMSRHASRCKILAPAWELNTPRMDPRSFDASSQQRAPRHENVHPSRACNVPQCNAGRTQPPPSRICNVSQENRGYGLPAPPVYHTTAPSTRDIVYVDARRKPSLISRSQGPSPPLEEYERYRAGGNTRSGSSTEDIWTASDEMRVLGPEWYQALSLGFCMDTVLCACACSIVVPEWMQVYCALINPRRGNHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CBL5</accession>
    <name>A0A177CBL5_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Actin-related protein 2/3 complex subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CC84DRAFT_1148236</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6">Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
            <location evidence="6">Cytoskeleton</location>
            <location evidence="6">Actin patch</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the ARPC4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG05083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035448.1">
        <property type="nucleotide sequence ID" value="XM_018176626.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CBL5"/>
    <dbReference type="FunCoup" id="A0A177CBL5">
        <property type="interactions" value="712"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CBL5"/>
    <dbReference type="GeneID" id="28760112"/>
    <dbReference type="InParanoid" id="A0A177CBL5"/>
    <dbReference type="OrthoDB" id="336240at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005885">
        <property type="term" value="C:Arp2/3 protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044396">
        <property type="term" value="P:actin cortical patch organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030041">
        <property type="term" value="P:actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034314">
        <property type="term" value="P:Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1460.20:FF:000001">
        <property type="entry name" value="Actin-related protein 2/3 complex subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1460.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034666">
        <property type="entry name" value="ARPC2/4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008384">
        <property type="entry name" value="ARPC4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22629:SF0">
        <property type="entry name" value="ACTIN-RELATED PROTEIN 2_3 COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22629">
        <property type="entry name" value="ARP2/3 COMPLEX 20 KD SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05856">
        <property type="entry name" value="ARPC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039100">
        <property type="entry name" value="ARPC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69645">
        <property type="entry name" value="Arp2/3 complex subunits"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="2 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00054835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR039100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAG05083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="169" mass="19525" checksum="BECD26B5D1EE0F7E" modified="2016-09-07" version="1">MSQSLRPYLQCVRSSLTAALSLANFASQASERHNVPEIEAASSPEVLLNPLTVSRNENERVLIEPSINSVRISIKIKQADEIEHILVHKFTRFLTQRAEAFFILRRKPVKGYDISFLITNFHTEEMLKHKLVDFIIQFMEEVDKEISEMKLFLNARARFVAESFLTPFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CBM6</accession>
    <name>A0A177CBM6_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 18">Galactose-1-phosphate uridylyltransferase</fullName>
            <ecNumber evidence="5 18">2.7.7.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">CC84DRAFT_1166281</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 18">
            <text>alpha-D-galactose 1-phosphate + UDP-alpha-D-glucose = alpha-D-glucose 1-phosphate + UDP-alpha-D-galactose</text>
            <dbReference type="Rhea" id="RHEA:13989"/>
            <dbReference type="ChEBI" id="CHEBI:58336"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:66914"/>
            <dbReference type="EC" id="2.7.7.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="17">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="17">Binds 1 Fe cation per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="16">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="16">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 18">Carbohydrate metabolism; galactose metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 18">Belongs to the galactose-1-phosphate uridylyltransferase type 1 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.12" evidence="5 18"/>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG04177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034542.1">
        <property type="nucleotide sequence ID" value="XM_018178919.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CBM6"/>
    <dbReference type="FunCoup" id="A0A177CBM6">
        <property type="interactions" value="373"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CBM6"/>
    <dbReference type="GeneID" id="28762405"/>
    <dbReference type="InParanoid" id="A0A177CBM6"/>
    <dbReference type="OrthoDB" id="418412at2759"/>
    <dbReference type="UniPathway" id="UPA00214"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008108">
        <property type="term" value="F:UDP-glucose:hexose-1-phosphate uridylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033499">
        <property type="term" value="P:galactose catabolic process via UDP-galactose, Leloir pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00608">
        <property type="entry name" value="GalT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.428.10:FF:000001">
        <property type="entry name" value="Galactose-1-phosphate uridylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.428.10:FF:000009">
        <property type="entry name" value="Galactose-1-phosphate uridylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001937">
        <property type="entry name" value="GalP_UDPtransf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019779">
        <property type="entry name" value="GalP_UDPtransf1_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005850">
        <property type="entry name" value="GalP_Utransf_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005849">
        <property type="entry name" value="GalP_Utransf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00209">
        <property type="entry name" value="galT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11943">
        <property type="entry name" value="GALACTOSE-1-PHOSPHATE URIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11943:SF1">
        <property type="entry name" value="GALACTOSE-1-PHOSPHATE URIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02744">
        <property type="entry name" value="GalP_UDP_tr_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01087">
        <property type="entry name" value="GalP_UDP_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000808">
        <property type="entry name" value="GalT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00117">
        <property type="entry name" value="GAL_P_UDP_TRANSF_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 18" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="12 18" id="KW-0299">Galactose metabolism</keyword>
    <keyword evidence="11 17" id="KW-0408">Iron</keyword>
    <keyword evidence="9 16 18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 18 21" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 18 21" id="KW-0808">Transferase</keyword>
    <keyword evidence="10 16" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Galactose-1-phosphate uridyl transferase N-terminal" evidence="19">
        <location>
            <begin position="8"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="Galactose-1-phosphate uridyl transferase C-terminal" evidence="20">
        <location>
            <begin position="216"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-UMP-histidine intermediate" evidence="14">
        <location>
            <position position="199"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="28"/>
            <end position="31"/>
        </location>
        <ligand>
            <name>UDP-alpha-D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="15">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>UDP-alpha-D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="15">
        <location>
            <begin position="77"/>
            <end position="78"/>
        </location>
        <ligand>
            <name>UDP-alpha-D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="15">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>UDP-alpha-D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="15">
        <location>
            <begin position="192"/>
            <end position="194"/>
        </location>
        <ligand>
            <name>UDP-alpha-D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="15">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>UDP-alpha-D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="215"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="315"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="332"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="334"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="347"/>
            <end position="348"/>
        </location>
        <ligand>
            <name>UDP-alpha-D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="352"/>
            <end position="353"/>
        </location>
        <ligand>
            <name>UDP-alpha-D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="15">
        <location>
            <position position="359"/>
        </location>
        <ligand>
            <name>UDP-alpha-D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00016340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000808-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR000808-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR000808-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR000808-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU000506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF01087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF02744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="OAG04177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="404" mass="46338" checksum="E0E3C1099BDC050A" modified="2016-09-07" version="1">MGEPILNDISHRRFNLLRGSWVLVSPHRNKRPWQGLQEKPSRTSLPDYDPECYLCPSNTRANGSKNPKFTETFVFVNDYSAVKEEQEEYHPEQNEGSLASRLLKAEAVTGKCYVICFSPSHHLTLADMAPAEIIPIIETWTNLYTAHLDPKSPLAEAAKALSLPAFSQGDIAIPNAQYRYMQIFENKGTTMGCSNPHPHGQVWTTTSLPEEPNTELQQLKKYRQEQSGCHLLVDYAKLESDQKERTVFENESFWAGVPYWAVWPFEVMIISKQHKRALVDFSNAERQQLAECMAEITRRYDNLFETQFPYSMGLHQAPLQGTEEEIESSHFHIHFYPPLLRSATVRKFQVGYEMLGEPQRDITPEQAAERLRACDGELYRKKLEHLTNGHAGNATHVCQEQQKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CCD4</accession>
    <name>A0A177CCD4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CC84DRAFT_792264</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG04438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034803.1">
        <property type="nucleotide sequence ID" value="XM_018187415.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CCD4"/>
    <dbReference type="STRING" id="1460663.A0A177CCD4"/>
    <dbReference type="GeneID" id="28770901"/>
    <dbReference type="InParanoid" id="A0A177CCD4"/>
    <dbReference type="OrthoDB" id="5374328at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090575">
        <property type="term" value="C:RNA polymerase II transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050936">
        <property type="entry name" value="AP-1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40621:SF7">
        <property type="entry name" value="BZIP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40621">
        <property type="entry name" value="TRANSCRIPTION FACTOR KAPC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="4">
        <location>
            <begin position="146"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="43"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="521"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="59"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="93"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="138"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="543"/>
            <end position="558"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAG04438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="558" mass="61382" checksum="7A97907C140946D2" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2023-06-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CCF0</accession>
    <name>A0A177CCF0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_834674</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG05315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035680.1">
        <property type="nucleotide sequence ID" value="XM_018187593.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CCF0"/>
    <dbReference type="GeneID" id="28771079"/>
    <dbReference type="InParanoid" id="A0A177CCF0"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008058006" evidence="1">
        <location>
            <begin position="23"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG05315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="91" mass="10008" checksum="67FC3781CB322D36" modified="2016-09-07" version="1">MLIWPHTCRLCRKLRLAGLACALVRPTPYRGASELDLESKSYAYILKIESSNQLALSLRRCVRGLPHPMLGGGVHIIVVLLARLLNTGTGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CCF7</accession>
    <name>A0A177CCF7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1260274</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG05006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035371.1">
        <property type="nucleotide sequence ID" value="XM_018184982.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CCF7"/>
    <dbReference type="GeneID" id="28768468"/>
    <dbReference type="InParanoid" id="A0A177CCF7"/>
    <dbReference type="OrthoDB" id="10442351at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG05006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="255" mass="28929" checksum="68D92EF2A4C80064" modified="2016-09-07" version="1">MMCQKLPRELRDLAYMHFWAQEDTMCEWLRVWYPSLLLGRTTHTPYDELCTGIRSLDVPVAAELVQWYYENRGADLGIGQSIERPLWFPGGIRTGSKWLLEALDLQDLPKFMTTDVFGAGVTPADCKLRALTARIDLSDYIHVAQSIQIDRLLEPMRTQHKSEGFTLCVNVVGWWTDDFPFDLISGLGSKLGEVFEKLAEGNVTASARIMLVQYVPEGEGSKVNIIEGVGNMLGASEDVWEEFLKEKLGRTSRRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CCM6</accession>
    <name>A0A177CCM6_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Signal recognition particle receptor subunit alpha homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Docking protein alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CC84DRAFT_826439</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Heterodimer of an alpha and a beta chain.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GTP-binding SRP family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG05076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035441.1">
        <property type="nucleotide sequence ID" value="XM_018187539.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CCM6"/>
    <dbReference type="FunCoup" id="A0A177CCM6">
        <property type="interactions" value="779"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CCM6"/>
    <dbReference type="GeneID" id="28771025"/>
    <dbReference type="InParanoid" id="A0A177CCM6"/>
    <dbReference type="OrthoDB" id="1727884at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005785">
        <property type="term" value="C:signal recognition particle receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005047">
        <property type="term" value="F:signal recognition particle binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14826">
        <property type="entry name" value="SR_alpha_SRX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000566">
        <property type="entry name" value="Signal recognition particle receptor subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.140:FF:000009">
        <property type="entry name" value="Signal sequence receptor alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000023">
        <property type="entry name" value="Signal sequence receptor alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.140">
        <property type="entry name" value="Signal recognition particle SRP54, nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007222">
        <property type="entry name" value="Sig_recog_particle_rcpt_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013822">
        <property type="entry name" value="Signal_recog_particl_SRP54_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036225">
        <property type="entry name" value="SRP/SRP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000897">
        <property type="entry name" value="SRP54_GTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042101">
        <property type="entry name" value="SRP54_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43134">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE RECEPTOR SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43134:SF1">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE RECEPTOR SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04086">
        <property type="entry name" value="SRP-alpha_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00448">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02881">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00962">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00963">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47364">
        <property type="entry name" value="Domain of the SRP/SRP receptor G-proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00300">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SRP54-type proteins GTP-binding" evidence="12">
        <location>
            <begin position="613"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="132"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="175"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="232"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00071429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00081194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS00300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OAG05076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="640" mass="68774" checksum="B3E7CBC6EF72379F" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CD00</accession>
    <name>A0A177CD00_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WD40 repeat-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CC84DRAFT_832184</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG05196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035561.1">
        <property type="nucleotide sequence ID" value="XM_018187570.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CD00"/>
    <dbReference type="FunCoup" id="A0A177CD00">
        <property type="interactions" value="142"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CD00"/>
    <dbReference type="GeneID" id="28771056"/>
    <dbReference type="InParanoid" id="A0A177CD00"/>
    <dbReference type="OrthoDB" id="10263272at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010997">
        <property type="term" value="F:anaphase-promoting complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990757">
        <property type="term" value="F:ubiquitin ligase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905786">
        <property type="term" value="P:positive regulation of anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033010">
        <property type="entry name" value="Cdc20/Fizzy"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19918">
        <property type="entry name" value="CELL DIVISION CYCLE 20 CDC20 FIZZY -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19918:SF5">
        <property type="entry name" value="MEIOSIS-SPECIFIC APC_C ACTIVATOR PROTEIN AMA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="629"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="123"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="212"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="263"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="400"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="22"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="402"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAG05196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="896" mass="97056" checksum="44B0B9A47163E63F" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CDM4</accession>
    <name>A0A177CDM4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1163963</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG05416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035781.1">
        <property type="nucleotide sequence ID" value="XM_018178375.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CDM4"/>
    <dbReference type="GeneID" id="28761861"/>
    <dbReference type="InParanoid" id="A0A177CDM4"/>
    <dbReference type="OrthoDB" id="3766445at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG05416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="292" mass="31830" checksum="B04BCF62E18A5BE4" modified="2016-09-07" version="1">MDRLASRLGLSRSPKSQSFKEWSDSATVDDVHGLLTNLIKSGTDDGQSAAFRPERLEALEGVLEKTLTNATGEVAIEGVQALLIKSHTSLANELEAASPTISLLLHSHACFPFAKEVPLTKDALVRSVGLITKGSDYMFSQEASFSQEPTIRARSKTARMEFVFSALAHPVPCTGVPTKEDVLDVLCRIRYPHPKSFTVQQRRTITELEPLAERLLPPSSALPSRDSLRISISALRPLANICNSMRDDKGVEAEKVLAGKESLDRIEFKEWAKAASLPGVLDRLIGVLSTPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CDP0</accession>
    <name>A0A177CDP0_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1247403</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG04919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035284.1">
        <property type="nucleotide sequence ID" value="XM_018184233.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CDP0"/>
    <dbReference type="STRING" id="1460663.A0A177CDP0"/>
    <dbReference type="GeneID" id="28767719"/>
    <dbReference type="InParanoid" id="A0A177CDP0"/>
    <dbReference type="OrthoDB" id="103819at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF5">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="2">
        <location>
            <begin position="21"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG04919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="628" mass="70087" checksum="99FB849E0BF33404" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CDX6</accession>
    <name>A0A177CDX6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_736153</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG05835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036200.1">
        <property type="nucleotide sequence ID" value="XM_018187236.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CDX6"/>
    <dbReference type="GeneID" id="28770722"/>
    <dbReference type="InParanoid" id="A0A177CDX6"/>
    <dbReference type="OrthoDB" id="4497018at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="356"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="425"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="472"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="368"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="472"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="490"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG05835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="500" mass="56555" checksum="F91BBC10BB1E2228" modified="2016-09-07" version="1">MSSWLHRLRGEHVQTNEDHVEQSNVVERSRAKPRQRPVDPKPKDPNAPLKRLQLHQKCLYERTMPGNAFVSAHVNRLQQGYYESKALHEGPLNNVYFVSVHFVFHPRDHHYHRFRAATIKVSVHTDFSSSDFDPEKGRYTPLGSHPRILKHAPELIYGAVSPENLQWNFNLSSSLGVSQAPLSATLNPSGGVKKTYRVYDMMSIQGSLRVLKSPLGSDFDVDDAMAVWTLEENLTQRSGLPREFDFVMLVHKPDDVQNVYLSVDLDATVSSWHGDYPQWYTNLSRYLPNVDYTLDLDTDIGQKFRPEKPGHGFNFADLPQALDQYVCMPGTMYPTTDSKPEDSGSADRNWSRYRQYEPKGSANDYRVSGAPPAASSEPMSPEKQINTWGQQFGPSPASVPTAQRQLVLPETLNVRVTLEHSTPRSPATYCYSGSPIGSQDPARQHSIRRRRSRSELKEYGVQQALQALAGETLKENGDIPKRAAKTARARSTERIVNDRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2023-06-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CEP0</accession>
    <name>A0A177CEP0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1176163</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG06104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036469.1">
        <property type="nucleotide sequence ID" value="XM_018180199.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CEP0"/>
    <dbReference type="GeneID" id="28763685"/>
    <dbReference type="InParanoid" id="A0A177CEP0"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG06104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="174" mass="19606" checksum="13089CAD2A12955E" modified="2016-09-07" version="1">MYHSICLVSRDRRRVAGLGVAHRELPKSCRELQGRVNASRGPFRLVTQISTIVLASCRWLARKLPNNDVNSSSRPRSFHCNRMAGLNSCGRTCANDSQADITKARITGWLLENTFVKVIPEAAIVEMTMPEAAIAVAVTVAVANKRLRRRLKLTERRFPSPWQSTVVHGRLFRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CFC5</accession>
    <name>A0A177CFC5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CC84DRAFT_1090768</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRP4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG06305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036670.1">
        <property type="nucleotide sequence ID" value="XM_018174372.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CFC5"/>
    <dbReference type="FunCoup" id="A0A177CFC5">
        <property type="interactions" value="1053"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CFC5"/>
    <dbReference type="GeneID" id="28757858"/>
    <dbReference type="InParanoid" id="A0A177CFC5"/>
    <dbReference type="OrthoDB" id="1650at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071034">
        <property type="term" value="P:CUT catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000467">
        <property type="term" value="P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071028">
        <property type="term" value="P:nuclear mRNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071051">
        <property type="term" value="P:poly(A)-dependent snoRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05789">
        <property type="entry name" value="S1_Rrp4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000038">
        <property type="entry name" value="Exosome complex component RRP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000050">
        <property type="entry name" value="Exosome complex component rrp4 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025721">
        <property type="entry name" value="Exosome_cplx_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026699">
        <property type="entry name" value="Exosome_RNA_bind1/RRP40/RRP4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048565">
        <property type="entry name" value="S1_RRP4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21321:SF4">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21321">
        <property type="entry name" value="PNAS-3 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14382">
        <property type="entry name" value="ECR1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21266">
        <property type="entry name" value="S1_RRP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110324">
        <property type="entry name" value="Ribosomal L27 protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0271">Exosome</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Exosome complex component N-terminal" evidence="8">
        <location>
            <begin position="40"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="RRP4 S1" evidence="9">
        <location>
            <begin position="91"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="18"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="21"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="35"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF14382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF21266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAG06305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="338" mass="36007" checksum="8F10AC1E10D62590" modified="2016-09-07" version="1">MPISILPPSAPIAAAHLRQDDSDEDMSDDDGLPVQSATSIVTPGETVTSDPQWMRGHGTYVPAESTTIISTVAGHLHKTNKLLSVQPLRARYTPEIGDLVVGRIVSVQTKKWTVDIAAPMLASLPLSAINLPGGILRRRTAVDELNIRTFFSEGDLLVAEVQSLHGDNTASLHTRSLKYGKLRNGLFTSLSGAGGGILSRRGGVVRSKRQTFTLQTSAGEIDVVLGVNGYIFVSAHKKSGHDEKDVSITSLDQGVSETLYSSQNDDIEPGVAREITRVSTLVKGLVACGRRVDEDMIVRVYEGAVELEAEEKVMGASERAGGAKGVVEAVLGRLEMGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CFQ8</accession>
    <name>A0A177CFQ8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_743983</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG06051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036416.1">
        <property type="nucleotide sequence ID" value="XM_018187271.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CFQ8"/>
    <dbReference type="GeneID" id="28770757"/>
    <dbReference type="InParanoid" id="A0A177CFQ8"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG06051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="157" mass="18100" checksum="F4D44A02E187B362" modified="2016-09-07" version="1">MTYSSIKHLSVNLVTSSYRLVGEDWQHSHWPVIAQLIPHCQSSRTYASMDHSTASLMMRRFWKRYIYFPISRSSVFPAFCSKTATGKHGRRFPGNFNVGILTLCSSSSQGSRLRVFQNWGNMTESRNNGILQYKDQSYSTACYHEAEKRELIVFLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CFS3</accession>
    <name>A0A177CFS3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_1186791</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG05580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035945.1">
        <property type="nucleotide sequence ID" value="XM_018180879.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CFS3"/>
    <dbReference type="GeneID" id="28764365"/>
    <dbReference type="InParanoid" id="A0A177CFS3"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:001515">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF11">
        <property type="entry name" value="MONOSACCHARIDE TRANSPORTER (HXT8), PUTATIVE (AFU_ORTHOLOGUE AFUA_2G08120)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="66"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="103"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="189"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="231"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="255"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="290"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="325"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="355"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="1"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAG05580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="451" mass="49602" checksum="732323F07804F38E" modified="2016-09-07" version="1">MDRWGRKAGVLYCAIFSLVGGAMLCGARNIEMFIVARFIAGWGSWGFLAVTPTYSAELAPPGLRGFFVGMNGVNIALGYAIASYTGMAFYFAESDAAKWRGPLGIALLWPAMMIAIIFIVPESPRFLLMKGRVEEAEKIVFRLHSVKGDPEQEFARSEFYQMRKQTELDRTLEPGWIAMFTKKGYRRRTALAMGFAFVGQSTGVLVINNYGPTLYATLGFDTKQQLELQCGWISVGIVFNAVGAVFMDKVGRKPLMLFGVAGCGVCLIIEAAIVATYAEEATNKAALAAGVAMFYLFLAVYSMGVDVAGVVFYSELFPNHIRAKGVCLSMATVALTDLVYLQATTTAFANIGWRFYLVFIIICALGTVFFYFFLPETKGIPLEEMARIFGDDVVVTLDDVHINHNTHQLVYRTGDEKDGLEHVATHQGLTPEVERAIKANAAEHKETVGKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CGA5</accession>
    <name>A0A177CGA5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CC84DRAFT_1241238</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG06625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036990.1">
        <property type="nucleotide sequence ID" value="XM_018184049.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CGA5"/>
    <dbReference type="GeneID" id="28767535"/>
    <dbReference type="InParanoid" id="A0A177CGA5"/>
    <dbReference type="OrthoDB" id="1606438at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016461">
        <property type="entry name" value="COMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001077">
        <property type="entry name" value="COMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712:SF12">
        <property type="entry name" value="STERIGMATOCYSTIN 8-O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00891">
        <property type="entry name" value="Methyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51683">
        <property type="entry name" value="SAM_OMT_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="O-methyltransferase C-terminal" evidence="4">
        <location>
            <begin position="244"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAG06625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="418" mass="46506" checksum="E79D90BC8FE267D5" modified="2016-09-07" version="1">MASRARQLVEILSQSISDIEDFLKTQDAPDLSIEQDVPLSFHANPKFASTKDAALLACKELSTLLGGSFAAITNQTTSEFANTQAICRFKIPSSFPPDRDHATYDELAANSGLPEPEVRRLVRSTLPSYIFLEKETGIVTRTAASKLLAYNPLMVQWVEMTATEIMPATLKIADAMEKWPQSGEPHQTGYNLANNTEDSAFTHMAKFPGRPEQFAQAMSLFSMGPGYSPKWLLENYPWDSLETGTVVDVGGSKGEYGIAIARKYPQIKVVIQDLPDVIEKAQSSAPADLGDRVEFMAHDFLTDQPIKDADVYLMRWILHDWSDAYSIRILRALIPALRKGARIVLHEYIVPEPGKTLTLQDRTLRIFDTAVRALTNGKEREANDWKALFAEADSRFQILSIEKPPVSSLGIIVAQWEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CGW9</accession>
    <name>A0A177CGW9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1257895</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG06586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036951.1">
        <property type="nucleotide sequence ID" value="XM_018184775.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CGW9"/>
    <dbReference type="GeneID" id="28768261"/>
    <dbReference type="InParanoid" id="A0A177CGW9"/>
    <dbReference type="OrthoDB" id="4107213at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG06586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="307" mass="33614" checksum="2BC307F877B4846A" modified="2016-09-07" version="1">MPDELSALLAPLLAPTLQRLLAPIKLSPLSRLPTSRLLTTALPNISSIELVSSSAFETDYAPLYTSLFHGGERERPNLIVERLRQDAQGKRAGSHRKVLGAAQFSVLLLDATEDAEDVVAVPYLQYIYVRSENRRQDLSELLHTLVLAVSLASSPNPTKAKVPFTLFETEPPTHGDDTAARKTALERTSIHARSGSKALMLRKPPVSSDGLPVYVSAHVQPGLEPDDPPLTLIWVIRPNPVHQGEALDVNKLGPVVLAAVYRSFRDEAFPEANIALAEEIAEKRRVMSEYCVMGLAEVTRGMYVGID</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CH23</accession>
    <name>A0A177CH23_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Golgi apparatus membrane protein TVP38</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Golgi apparatus membrane protein tvp38</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CC84DRAFT_1092317</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Golgi membrane protein involved in vesicular trafficking and spindle migration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TVP38/TMEM64 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG06149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036514.1">
        <property type="nucleotide sequence ID" value="XM_018174446.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CH23"/>
    <dbReference type="STRING" id="1460663.A0A177CH23"/>
    <dbReference type="GeneID" id="28757932"/>
    <dbReference type="InParanoid" id="A0A177CH23"/>
    <dbReference type="OrthoDB" id="166803at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051076">
        <property type="entry name" value="Golgi_membrane_TVP38/TMEM64"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032816">
        <property type="entry name" value="VTT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47549:SF2">
        <property type="entry name" value="GOLGI APPARATUS MEMBRANE PROTEIN TVP38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47549">
        <property type="entry name" value="GOLGI APPARATUS MEMBRANE PROTEIN TVP38-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09335">
        <property type="entry name" value="VTT_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="103"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="157"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="184"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="220"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="VTT" evidence="11">
        <location>
            <begin position="92"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF09335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OAG06149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="317" mass="36145" checksum="1324586D7784477B" modified="2016-09-07" version="1">MGNVRGKPTGEAPEETDYRPVNWKRVFLTPKYIPWHIIGIAVLIFTVYITIHHDEVVEKLRPFSEKLRDLPAGWLIPIAILFIISFPPLFGHEIVALLCGVVWGLWIGFAIVAAGTFVGEVGTWFAFLYTLRRKAAKLERTNLNYGALARLTRDGGFWIVLVIRLSAIPSHFSTAVFATCNVNFWYFFVATFLSLPKQIFLVYLGVLLVQQKASNLGKNIMFGAVFVVTVVLGIWIWIKMAKVKKILLEEQAQRRQQNLEDEMRVADKEAEQRRFEISEPQAAWTMPQQMSMPRVPPGEYVVRQSWGLPEPPPGRAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CHS4</accession>
    <name>A0A177CHS4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1216089</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG07084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037449.1">
        <property type="nucleotide sequence ID" value="XM_018182769.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CHS4"/>
    <dbReference type="GeneID" id="28766255"/>
    <dbReference type="InParanoid" id="A0A177CHS4"/>
    <dbReference type="OrthoDB" id="10549511at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="262"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="48"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="24"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="39"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="284"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG07084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="298" mass="34014" checksum="C4D1EF4E3170D69C" modified="2016-09-07" version="1">MSAHKVPQWPPELNYGPNPPRPRTATTSVAQLDATHNQEATKEAVPQKRTAEELLEQKRSKLQKQHENLNAYFNAEKEEYKQISTLLQQEKLTSFNTIKHLEQEKDQLRSELDSKTKLTTSLDTDLQRVMKDLKSWKEECETRDAEMKEANAKMDRLEGDNYQLKQDLAKNKKALEARKSFCDKKEAIIRDMTDNANNCRQVLAAKEKEMQEKESDKVHLKERLRNSDLALESRNKEIRQKNEEIAGLSAIRDSILKVAAEAQKTTAGRAEKSAPALPPARTVTLPSTRAANSAHSRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CHS5</accession>
    <name>A0A177CHS5_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nicotinamide N-methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1217569</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG06337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036702.1">
        <property type="nucleotide sequence ID" value="XM_018182906.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CHS5"/>
    <dbReference type="GeneID" id="28766392"/>
    <dbReference type="InParanoid" id="A0A177CHS5"/>
    <dbReference type="OrthoDB" id="407325at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF104">
        <property type="entry name" value="N-METHYLTRANSFERASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17750)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG06337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="312" mass="35090" checksum="5432A8525585110E" modified="2016-09-07" version="1">MLLPSLVTLRHPTSHELTPEDIFESSLGGVFVNDLQNQHGDDPTTTILYRPSNPAYAEIALHPADVTGEEQRRKFAHYLWNAGILMAELVGGRPAGDMKHDVNELWGEQSRWRDGEWWTGEEEEAKWAVKGETVLELGAGVGLGGIMSAVTGAAEVAITDYPAPPILETLRKNAETNIPAEQRAHTAVYGHQWNVLDDEFSTSHAHHYTRILAADCLWMPHEHENLAQSMLHFLSDSPDARVYVIAGFHTGRAKVAPFFEETIPEVGLEIEEIYEMDAEGRRRAWAAERDGGREDVGERKKWCVLARLRRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CI34</accession>
    <name>A0A177CI34_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 16">Glutathione reductase</fullName>
            <ecNumber evidence="3 16">1.8.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CC84DRAFT_1216169</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11 16">Catalyzes the reduction of glutathione disulfide (GSSG) to reduced glutathione (GSH). Constitutes the major mechanism to maintain a high GSH:GSSG ratio in the cytosol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 16">
            <text>2 glutathione + NADP(+) = glutathione disulfide + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11740"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58297"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.8.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="13">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="16">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 15">Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.7" evidence="3 16"/>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG07174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037539.1">
        <property type="nucleotide sequence ID" value="XM_018182777.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CI34"/>
    <dbReference type="FunCoup" id="A0A177CI34">
        <property type="interactions" value="1080"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CI34"/>
    <dbReference type="GeneID" id="28766263"/>
    <dbReference type="InParanoid" id="A0A177CI34"/>
    <dbReference type="OrthoDB" id="5956163at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004362">
        <property type="term" value="F:glutathione-disulfide reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.390.30:FF:000003">
        <property type="entry name" value="Glutathione reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000235">
        <property type="entry name" value="Glutathione reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006322">
        <property type="entry name" value="Glutathione_Rdtase_euk/bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046952">
        <property type="entry name" value="GSHR/TRXR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001100">
        <property type="entry name" value="Pyr_nuc-diS_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012999">
        <property type="entry name" value="Pyr_OxRdtase_I_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01421">
        <property type="entry name" value="gluta_reduc_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004776">
        <property type="entry name" value="PRK06116.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42737">
        <property type="entry name" value="GLUTATHIONE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42737:SF2">
        <property type="entry name" value="GLUTATHIONE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000350">
        <property type="entry name" value="Mercury_reductase_MerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="FAD/NAD-linked reductases, dimerisation (C-terminal) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00076">
        <property type="entry name" value="PYRIDINE_REDOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 13 15" id="KW-0274">FAD</keyword>
    <keyword evidence="5 15" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="13" id="KW-0520">NAD</keyword>
    <keyword evidence="16" id="KW-0521">NADP</keyword>
    <keyword evidence="13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9 15" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="18">
        <location>
            <begin position="11"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="Pyridine nucleotide-disulphide oxidoreductase dimerisation" evidence="17">
        <location>
            <begin position="355"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="12">
        <location>
            <position position="456"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="184"/>
            <end position="191"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="277"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="318"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="14">
        <location>
            <begin position="47"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00056905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU365016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="OAG07174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="467" mass="51145" checksum="A1FFFDDD74D8C5BE" modified="2016-09-07" version="1">MAPVTQTEECDYLVIGIGSGGIASARRAAKHGAKVISIESKRYGGTCVNVGCVPKKITWNAAAIAETFKDARAYGFGGYDTPTFDWPTFKKKRDAYVKRLNGIYENNLNKDEIKHYKGRAKFVAKDEVEVALNEGGTQRIKGKHILIATGGRPKVPDIPGAEFCIDSDGFFDLETQPKSIATSGAGYIGVEMSGMMHALGTETHFFIRGQTLLRTFDPMIQDTVTKEYERQGVHLYKGSQITKVEDIGNGMKRVTYQETESKKESTLEVECVLFATGRSPEVDALHIKDLGMKLNDKNHIMVDEYQNTNISNIYAIGDASDSGFELTPVAIAAGRRLSDRLFGGKPDAHLSYENIPSVVFAHPEIGSIGLTEPAAREKYGDKVKIYKTEFTGMYYAMMEQGEKGPTAYKIICVGEEEKVVGLHILGQGSSEILQGFGVAIKMGATKKDFDNCVAIHPVSAEELVTMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CI84</accession>
    <name>A0A177CI84_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Peroxidase</fullName>
            <ecNumber evidence="12">1.11.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CC84DRAFT_1187409</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="9 12">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="9 12">Binds 2 calcium ions per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
        <text evidence="9">Binds 1 heme b (iron(II)-protoporphyrin IX) group per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 12">Belongs to the peroxidase family. Ligninase subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.-" evidence="12"/>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG06540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036905.1">
        <property type="nucleotide sequence ID" value="XM_018180931.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CI84"/>
    <dbReference type="STRING" id="1460663.A0A177CI84"/>
    <dbReference type="GeneID" id="28764417"/>
    <dbReference type="InParanoid" id="A0A177CI84"/>
    <dbReference type="OrthoDB" id="2113341at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000302">
        <property type="term" value="P:response to reactive oxygen species"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.420.10">
        <property type="entry name" value="Peroxidase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044831">
        <property type="entry name" value="Ccp1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002016">
        <property type="entry name" value="Haem_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001621">
        <property type="entry name" value="Ligninase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019794">
        <property type="entry name" value="Peroxidases_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31356:SF66">
        <property type="entry name" value="CATALASE-PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31356">
        <property type="entry name" value="THYLAKOID LUMENAL 29 KDA PROTEIN, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00141">
        <property type="entry name" value="peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00462">
        <property type="entry name" value="LIGNINASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00458">
        <property type="entry name" value="PEROXIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00436">
        <property type="entry name" value="PEROXIDASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50873">
        <property type="entry name" value="PEROXIDASE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0106">Calcium</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 9" id="KW-0408">Iron</keyword>
    <keyword evidence="4 9 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 12" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007948968" description="Peroxidase" evidence="12">
        <location>
            <begin position="17"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="Plant heme peroxidase family profile" evidence="14">
        <location>
            <begin position="63"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="16"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="276"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="23"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="72"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="210"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="10">
        <location>
            <position position="68"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="42"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="59"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR601621-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR601621-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR601621-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR601621-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OAG06540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="301" mass="30762" checksum="D93C1B932273242B" modified="2016-09-07" version="1">MLFQSAILFTLGAAAAAGGGGRSSTSSSSSSSSSGSSSSTDCSTWSRVASDLGTTFQGCGPAARGAIRAPFHDCINNGCDGSLILGDECGRSENAGLTATCALLAEKAKQYSVGTADMIQFAAAVAIAVCPLGPRVKALVGRTDSSTPAEEGQVPATKDPIDSILGKFAAVGMSANDVVALVGSHTAGTQSFDDPSQAGKALDSTPSKWDVKFYSETKAGTAPYSFSSDRRMTNDSSTEGSWNRFAHSQGAWASAFTSAWDRFVVVGNDVDSLNDCSSSLPGSSRRRAEGMSRPMGAGAFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CIH6</accession>
    <name>A0A177CIH6_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 10">U3 small nucleolar RNA-associated protein 25</fullName>
            <shortName evidence="10">U3 snoRNA-associated protein 25</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CC84DRAFT_1163526</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10">DEAD-box RNA helicase-like protein required for pre-18S rRNA processing, specifically at sites A0, A1, and A2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 10">Component of the ribosomal small subunit (SSU) processome composed of at least 40 protein subunits and snoRNA U3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Nucleus</location>
            <location evidence="2 10">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the UTP25 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG07315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037680.1">
        <property type="nucleotide sequence ID" value="XM_018178283.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CIH6"/>
    <dbReference type="FunCoup" id="A0A177CIH6">
        <property type="interactions" value="1218"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CIH6"/>
    <dbReference type="GeneID" id="28761769"/>
    <dbReference type="InParanoid" id="A0A177CIH6"/>
    <dbReference type="OrthoDB" id="10264378at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034511">
        <property type="term" value="F:U3 snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002356">
        <property type="entry name" value="U3 small nucleolar RNA-associated protein 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010678">
        <property type="entry name" value="UTP25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053939">
        <property type="entry name" value="UTP25_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053940">
        <property type="entry name" value="UTP25_NTPase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12933">
        <property type="entry name" value="ORF PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12933:SF0">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 25 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06862">
        <property type="entry name" value="Utp25_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22916">
        <property type="entry name" value="UTP25_NTPase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="6 10" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="7 10" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="UTP25 NTP hydrolase-like" evidence="13">
        <location>
            <begin position="296"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="domain" description="UTP25 C-terminal" evidence="12">
        <location>
            <begin position="565"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="70"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF06862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF22916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OAG07315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="757" mass="85304" checksum="1B2FF6D7F92C9F77" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CIR8</accession>
    <name>A0A177CIR8_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Alpha/beta-hydrolase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1059453</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG06749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037114.1">
        <property type="nucleotide sequence ID" value="XM_018173570.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CIR8"/>
    <dbReference type="STRING" id="1460663.A0A177CIR8"/>
    <dbReference type="GeneID" id="28757056"/>
    <dbReference type="InParanoid" id="A0A177CIR8"/>
    <dbReference type="OrthoDB" id="10260961at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42103:SF2">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42103">
        <property type="entry name" value="ALPHA/BETA-HYDROLASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="235"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="249"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG06749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="388" mass="42766" checksum="949592159144EC70" modified="2016-09-07" version="1" fragment="single">WSCTVPSVHDDTPLNVRIYHPSTLPSQSDKPWRKRGIVMAHPYAPMGGSYDDRVVGIVAEEFLAAGWVVGTFNFRGAHAAKGRTSWSGKPELSDYHSFAAFFMHYLSYLRPNPPPGAAFTPDQPPVPPTVAMDGRAPIVVLGGYSYGSLILRNLPPLPSILQPFAAPTPGSAAHEILLTAHKLADQDNLEFINAARDTERRRRRGHEHKLSVKMGGEETSPGIRRSSREIRRSVDGGSRSLDLGSRLRSLSHGHHHRRGKDASPQPQPAAPENGSVIQIPQVRYLLVSPITPPTATLAAPALARGFWSRAGDGDASLKMHETLAVYGDQDMFASTRKMREWVARTEAENQTQGGFRGVEVAGAGHFWHEQGVERELREALRGWERRVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CJD4</accession>
    <name>A0A177CJD4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1216342</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG07371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037736.1">
        <property type="nucleotide sequence ID" value="XM_018182791.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CJD4"/>
    <dbReference type="GeneID" id="28766277"/>
    <dbReference type="InParanoid" id="A0A177CJD4"/>
    <dbReference type="OrthoDB" id="10258585at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG07371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="119" mass="13414" checksum="BEDDAFB6C48FEC51" modified="2016-09-07" version="1">MAPFFLDILSDHARKYARGKQGKVWYCGRVLLRSFAVKRQKLVEDRAVYASNIPRDATFEKIEETSKKANIIERGVVGRLGIGMSSAEDGNFDDVLDLCIHSEVEDDLMHLEALSDQVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CJE1</accession>
    <name>A0A177CJE1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Aldehyde dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CC84DRAFT_1163735</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Amino-acid degradation; 4-aminobutanoate degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG07613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037978.1">
        <property type="nucleotide sequence ID" value="XM_018178326.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CJE1"/>
    <dbReference type="STRING" id="1460663.A0A177CJE1"/>
    <dbReference type="GeneID" id="28761812"/>
    <dbReference type="InParanoid" id="A0A177CJE1"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004777">
        <property type="term" value="F:succinate-semialdehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009450">
        <property type="term" value="P:gamma-aminobutyric acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07103">
        <property type="entry name" value="ALDH_F5_SSADH_GabD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000023">
        <property type="entry name" value="Succinate-semialdehyde dehydrogenase (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000004">
        <property type="entry name" value="Succinate-semialdehyde dehydrogenase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050740">
        <property type="entry name" value="Aldehyde_DH_Superfamily"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43353:SF7">
        <property type="entry name" value="SUCCINATE SEMIALDEHYDE DEHYDROGENASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43353">
        <property type="entry name" value="SUCCINATE-SEMIALDEHYDE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="4">
        <location>
            <begin position="29"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAG07613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="501" mass="54537" checksum="9DF79B414296ABA1" modified="2016-09-07" version="1">MGSAQKYELPFKLNNPDLLHSLSFVHGEWKKSKSGKTFEVVDPGTGKAWTECPTNDASDVDEAVQSSQRCFEEYKKISPRARAQMLFKWDSLIRENKEDIATILVYETGKPRAEAYGEIDYSTGFTWWFAGEAERIQGSVFTPALPDRRVFTIKQPLGVAAALVPWNFPIAMILRKAGAALAAGCTMIVKPSPETPITILTLAYLADKAGFPKGALNVLTTNLDKTPELSEALCRHDLVKKVSFTGSTRVGKLVAKICSDNLKKVTLELGGNCPVLIFDDANVDQAMGQIFALKYRHAGQACITANRIYVQSGIFDNFLERWNAESQKIVVGHGADKETTMGPVTTPRGIEKALALVNDAKSKGAQIHTGGNKISKNGGYFFEPTVITGVTPDMDIASEEIFAPVCTFLKFDTEEEAVKAANNTSMGLASYCFTKNVDRLWRLFENLEAGMIGLNTGNSSAAESPFGGIKQSGYGKESGKDVAVAEYLITKTGTFTLEGQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CJQ9</accession>
    <name>A0A177CJQ9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CC84DRAFT_1056687</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>myo-inositol(out) + H(+)(out) = myo-inositol(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:60364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG07212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037577.1">
        <property type="nucleotide sequence ID" value="XM_018173545.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CJQ9"/>
    <dbReference type="GeneID" id="28757031"/>
    <dbReference type="InParanoid" id="A0A177CJQ9"/>
    <dbReference type="OrthoDB" id="6339427at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005366">
        <property type="term" value="F:myo-inositol:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904679">
        <property type="term" value="P:myo-inositol import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000073">
        <property type="entry name" value="MFS myo-inositol transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050814">
        <property type="entry name" value="Myo-inositol_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020">
        <property type="entry name" value="PROTON MYO-INOSITOL COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020:SF12">
        <property type="entry name" value="PROTON MYO-INOSITOL COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="39"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="62"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="87"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="111"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="146"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="174"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="298"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="323"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="350"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="398"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="1"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OAG07212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="519" mass="56019" checksum="B45FC2D3DB2CDB89" modified="2016-09-07" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CKG3</accession>
    <name>A0A177CKG3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CC84DRAFT_1204866</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG07330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037695.1">
        <property type="nucleotide sequence ID" value="XM_018181934.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CKG3"/>
    <dbReference type="STRING" id="1460663.A0A177CKG3"/>
    <dbReference type="ESTHER" id="9pleo-a0a177ckg3">
        <property type="family name" value="Fungal_carboxylesterase_lipase"/>
    </dbReference>
    <dbReference type="GeneID" id="28765420"/>
    <dbReference type="InParanoid" id="A0A177CKG3"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007948961" description="Carboxylic ester hydrolase" evidence="3">
        <location>
            <begin position="18"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="20"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAG07330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="536" mass="59280" checksum="18E56B30E6F53C18" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CLJ9</accession>
    <name>A0A177CLJ9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF1279 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_1175449</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG07699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038064.1">
        <property type="nucleotide sequence ID" value="XM_018180157.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CLJ9"/>
    <dbReference type="FunCoup" id="A0A177CLJ9">
        <property type="interactions" value="18"/>
    </dbReference>
    <dbReference type="GeneID" id="28763643"/>
    <dbReference type="InParanoid" id="A0A177CLJ9"/>
    <dbReference type="OrthoDB" id="426386at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045866">
        <property type="entry name" value="FAM210A/B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009688">
        <property type="entry name" value="FAM210A/B-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21377">
        <property type="entry name" value="PROTEIN FAM210B, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21377:SF0">
        <property type="entry name" value="PROTEIN FAM210B, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06916">
        <property type="entry name" value="FAM210A-B_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="106"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1279" evidence="3">
        <location>
            <begin position="97"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAG07699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="248" mass="27629" checksum="255FCFD776D7835E" modified="2016-09-07" version="1">MNAPAVRIWTEQLLFRGAFSRPAAAGRPQTFTRTLSHFQPRAPRGSLQRSPLCILRNGRATVNPRFRTLRFKSDKPSHTPNPTPNLGSPEPALTLSQRLKRLSKQYGWLAVGVYFGLSALDFPFCYLAVRMLGTERMGHYEHVVVEGIKSLIRIPFPTLFQGSRDLEGPIAEEIREAAEREETLGHDGGKVVGHNGAAEASLWTQLALAYAVHKSLIFFRIPLTAAVLPKVAKTLRKWGWNVGKPKPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CLM7</accession>
    <name>A0A177CLM7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Microbial-type PARG catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1162197</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038571.1">
        <property type="nucleotide sequence ID" value="XM_018177937.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CLM7"/>
    <dbReference type="STRING" id="1460663.A0A177CLM7"/>
    <dbReference type="GeneID" id="28761423"/>
    <dbReference type="InParanoid" id="A0A177CLM7"/>
    <dbReference type="OrthoDB" id="9985428at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="entry name" value="Leucine Aminopeptidase, subunit E, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012664">
        <property type="entry name" value="CHP02452"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019261">
        <property type="entry name" value="PARG_cat_microbial"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02452">
        <property type="entry name" value="TIGR02452 family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35596">
        <property type="entry name" value="DUF2263 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35596:SF1">
        <property type="entry name" value="MICROBIAL-TYPE PARG CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10021">
        <property type="entry name" value="PARG_cat_microb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="Macro domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Microbial-type PARG catalytic" evidence="1">
        <location>
            <begin position="54"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG08206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="274" mass="30333" checksum="0EBC48960C766164" modified="2016-09-07" version="1">MLDLATRRKICEDTILRSASITEETPGASLKSEFISSQLPLLDNQHPAFPSLTLKPIKIHNSDAFELARKLYPSKGKVGVLNLASDIQPGGGWRYTLSKTQEEALCYSSTLYATLKPEWYPWHNTGPRSCAGIFSPDIVVFRDTIDNGLVELPAAERHLVSVITVAAPCLPKLTEDGEHFAVASDLRDLREKIILTLRMAAMKGVTKLVLGAMGCGAYHCPPHVVAEEMKKAIERDEFKGWFEDLPFAVYAAGPVGRQNFEVFEKVFKELAIES</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2023-06-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CM11</accession>
    <name>A0A177CM11_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_564107</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038656.1">
        <property type="nucleotide sequence ID" value="XM_018186710.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CM11"/>
    <dbReference type="GeneID" id="28770196"/>
    <dbReference type="InParanoid" id="A0A177CM11"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG08291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="108" mass="12453" checksum="B92897041A52CCFD" modified="2016-09-07" version="1">MLGRQLRSEPSQSYCYTLKLCSPPASRLPEVIPGHPTCQLELAMHSVREAVEPMLNILSRWVDARWMQRGRSNHACVRWYGATPSQAQNMNDAKTVLLWLQEHLRCFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CMQ0</accession>
    <name>A0A177CMQ0_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Chromosome segregation in meiosis protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CC84DRAFT_1140625</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Plays an important role in the control of DNA replication and the maintenance of replication fork stability.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the CSM3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038515.1">
        <property type="nucleotide sequence ID" value="XM_018176292.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CMQ0"/>
    <dbReference type="STRING" id="1460663.A0A177CMQ0"/>
    <dbReference type="GeneID" id="28759778"/>
    <dbReference type="InParanoid" id="A0A177CMQ0"/>
    <dbReference type="OrthoDB" id="437078at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031298">
        <property type="term" value="C:replication fork protection complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000076">
        <property type="term" value="P:DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043111">
        <property type="term" value="P:replication fork arrest"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031297">
        <property type="term" value="P:replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012923">
        <property type="entry name" value="Csm3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040038">
        <property type="entry name" value="TIPIN/Csm3/Swi3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13220">
        <property type="entry name" value="TIMELESS INTERACTING-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13220:SF11">
        <property type="entry name" value="TIMELESS-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07962">
        <property type="entry name" value="Swi3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3 7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0236">DNA replication inhibitor</keyword>
    <keyword evidence="5 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromosome segregation in meiosis protein 3" evidence="9">
        <location>
            <begin position="74"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="33"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="197"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="33"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU366049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAG08150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="270" mass="29880" checksum="EEA137B5BA1F38CC" modified="2016-09-07" version="1">MAAAAAIPSTNDIPDDDELDAILNGTLNGQDIFNISNPELQTQPSRPSKPTADDSGLGIDEEIKVVKKREPIPKLDDNRLLSDPGIPKLRRISKERLKFKGKGHEYGDIARMLNMYQFWLDELYPRAKFADGLAMIEKLGHSKRVQMMRKEWIDEGKPKHNAREDEDEDVVEVDNANEFVQRVDDLMEDVQGEITRSIEEDARRSVANGARGASAPPGEPDEDELDTLLAGDPAPVLPPTAAAVNTATNVEDDDPFADAMDAMADMDGMW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CN03</accession>
    <name>A0A177CN03_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1214848</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038707.1">
        <property type="nucleotide sequence ID" value="XM_018182678.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CN03"/>
    <dbReference type="STRING" id="1460663.A0A177CN03"/>
    <dbReference type="GeneID" id="28766164"/>
    <dbReference type="InParanoid" id="A0A177CN03"/>
    <dbReference type="OrthoDB" id="5322539at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35041:SF6">
        <property type="entry name" value="FORMYLMETHIONINE DEFORMYLASE-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35041">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008058380" evidence="2">
        <location>
            <begin position="20"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="351"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG08342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="424" mass="46263" checksum="24FA7BEEE3E47311" modified="2016-09-07" version="1">MPLLAVAALISWTVPFAAVISPGSLPVALNETQHTIPYQIPQLPTLFDNYGSFTDTVADGSNPEGPLTSIGGVVTSINGRVATTELWQVALGTAVSGQIAALAMRYRNMTYQYQFYGPVLKCVTVKNVTKLKNTLNNTFQGNLTSANYTSWVAGSGLVSENPQIRPETLDQFSDESTGAGIYIARGGGSGYDGAPALSSNTNATECRLHNGSYNVAFQFRYPEQNLTVLNLDYGAPIGLSQETLYKNLPREAYAGIMEAFCRLLVGYISGPPDPSTTPWTQQTFFTSANILHIDWSEAEKTRTGLEQLFQNITLSLLSRSSFIKNSTEADFIPITAFSFVNVYRYDHIGLFLAYGLALLGTLLCAIVGLHAAWANKGSYRNTFSTFVRSTDNDELRSLLDSEDDGRDPLPKQLGPVELVMHRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CN34</accession>
    <name>A0A177CN34_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Dolichol-phosphate mannosyltransferase subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_1162280</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Stabilizer subunit of the dolichol-phosphate mannose (DPM) synthase complex; tethers catalytic subunit to the ER.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the dolichol-phosphate mannose (DPM) synthase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Endoplasmic reticulum membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the DPM3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038675.1">
        <property type="nucleotide sequence ID" value="XM_018177953.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CN34"/>
    <dbReference type="STRING" id="1460663.A0A177CN34"/>
    <dbReference type="GeneID" id="28761439"/>
    <dbReference type="InParanoid" id="A0A177CN34"/>
    <dbReference type="OrthoDB" id="2014333at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033185">
        <property type="term" value="C:dolichol-phosphate-mannose synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013174">
        <property type="entry name" value="DPM3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16433">
        <property type="entry name" value="DOLICHOL-PHOSPHATE MANNOSYLTRANSFERASE SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16433:SF0">
        <property type="entry name" value="DOLICHOL-PHOSPHATE MANNOSYLTRANSFERASE SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08285">
        <property type="entry name" value="DPM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAG08310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="94" mass="10395" checksum="F2C5F5E534699FAF" modified="2016-09-07" version="1">MTRAQQTISIALLFTSLYLAVFLEIVSFPEKIQSEVVPVLPFWALVSFGAYLLFKLGWGVFTFNDVPEAHKELMSQIAEARAELSAKGVDVGSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CNC4</accession>
    <name>A0A177CNC4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_600033</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG09013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039378.1">
        <property type="nucleotide sequence ID" value="XM_018186836.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CNC4"/>
    <dbReference type="FunCoup" id="A0A177CNC4">
        <property type="interactions" value="25"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CNC4"/>
    <dbReference type="GeneID" id="28770322"/>
    <dbReference type="InParanoid" id="A0A177CNC4"/>
    <dbReference type="OrthoDB" id="71672at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06869">
        <property type="entry name" value="PX_UP2_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047168">
        <property type="entry name" value="LEC1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024554">
        <property type="entry name" value="LEC1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024555">
        <property type="entry name" value="PX-associated"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47185">
        <property type="entry name" value="PX DOMAIN-CONTAINING PROTEIN YPR097W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47185:SF1">
        <property type="entry name" value="PX DOMAIN-CONTAINING PROTEIN YPR097W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12825">
        <property type="entry name" value="DUF3818"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12828">
        <property type="entry name" value="PXB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PX" evidence="2">
        <location>
            <begin position="235"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="292"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="333"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="353"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG09013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="927" mass="105033" checksum="D045448B18AA7554" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CNE9</accession>
    <name>A0A177CNE9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phosphotransferase</fullName>
            <ecNumber evidence="6">2.7.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CC84DRAFT_1141271</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the hexokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.-" evidence="6"/>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038867.1">
        <property type="nucleotide sequence ID" value="XM_018176318.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CNE9"/>
    <dbReference type="STRING" id="1460663.A0A177CNE9"/>
    <dbReference type="GeneID" id="28759804"/>
    <dbReference type="InParanoid" id="A0A177CNE9"/>
    <dbReference type="OrthoDB" id="419537at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00180"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005536">
        <property type="term" value="F:D-glucose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008865">
        <property type="term" value="F:fructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004340">
        <property type="term" value="F:glucokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019158">
        <property type="term" value="F:mannokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001678">
        <property type="term" value="P:intracellular glucose homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006013">
        <property type="term" value="P:mannose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd24000">
        <property type="entry name" value="ASKHA_NBD_HK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.367.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001312">
        <property type="entry name" value="Hexokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022673">
        <property type="entry name" value="Hexokinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022672">
        <property type="entry name" value="Hexokinase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443">
        <property type="entry name" value="HEXOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443:SF24">
        <property type="entry name" value="PHOSPHOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00349">
        <property type="entry name" value="Hexokinase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03727">
        <property type="entry name" value="Hexokinase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00475">
        <property type="entry name" value="HEXOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51748">
        <property type="entry name" value="HEXOKINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="4 6" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Hexokinase N-terminal" evidence="8">
        <location>
            <begin position="102"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="Hexokinase C-terminal" evidence="9">
        <location>
            <begin position="300"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="74"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAG08502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="555" mass="61589" checksum="98862D2486C27977" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CNN4</accession>
    <name>A0A177CNN4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RTA1 like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CC84DRAFT_581002</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038893.1">
        <property type="nucleotide sequence ID" value="XM_018186760.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CNN4"/>
    <dbReference type="STRING" id="1460663.A0A177CNN4"/>
    <dbReference type="GeneID" id="28770246"/>
    <dbReference type="InParanoid" id="A0A177CNN4"/>
    <dbReference type="OrthoDB" id="3358017at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007568">
        <property type="entry name" value="RTA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465:SF28">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04479">
        <property type="entry name" value="RTA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="95"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="140"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="185"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="233"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="271"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="317"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAG08528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="347" mass="39965" checksum="9B30DC21C6943156" modified="2016-09-07" version="1">MTAMLELLVTRYVELPKRGHPEQYAFNPFIYDPNVPCAIVGAVVILSLSAVLVYQYVRYRSWFFWTALIGILMEVIGYICRLVSATDTERNGPFLIAFLMILLAPSFLAAACYMAFSRIVWFSCPTHALRFKTLWCFPRYITPTFVIFDLFSFVIQLAGASTISRAYDHDASPSRSIESAEKRVVAGRVILVLGLILQLSCYMAFAIIAMRYFVISLHWRHEDLGDFHMFRRLSYFINMAAGLITLRAIYRTLEIPQDKTTGLQYLQQHEWCFWCFDAVPVALVLLVMAVWHPGRYLPRSYTGWVLDKTRAVREKEALRPGSPTEEAEMKNFTPKDFQPRESVTIQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CPA3</accession>
    <name>A0A177CPA3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Interferon-induced GTP-binding protein Mx</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CC84DRAFT_1240181</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039085.1">
        <property type="nucleotide sequence ID" value="XM_018184007.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CPA3"/>
    <dbReference type="STRING" id="1460663.A0A177CPA3"/>
    <dbReference type="GeneID" id="28767493"/>
    <dbReference type="InParanoid" id="A0A177CPA3"/>
    <dbReference type="OrthoDB" id="415706at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048312">
        <property type="term" value="P:intracellular distribution of mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000266">
        <property type="term" value="P:mitochondrial fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016559">
        <property type="term" value="P:peroxisome fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08771">
        <property type="entry name" value="DLP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001425">
        <property type="entry name" value="Dynamin GTPase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022812">
        <property type="entry name" value="Dynamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001401">
        <property type="entry name" value="Dynamin_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000375">
        <property type="entry name" value="Dynamin_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030381">
        <property type="entry name" value="G_DYNAMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020850">
        <property type="entry name" value="GED_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566">
        <property type="entry name" value="DYNAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566:SF149">
        <property type="entry name" value="GTPASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G11890)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01031">
        <property type="entry name" value="Dynamin_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00195">
        <property type="entry name" value="DYNAMIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00053">
        <property type="entry name" value="DYNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51718">
        <property type="entry name" value="G_DYNAMIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51388">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynamin-type G" evidence="4">
        <location>
            <begin position="37"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="GED" evidence="3">
        <location>
            <begin position="608"/>
            <end position="699"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAG08720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="707" mass="79145" checksum="3C31C69028D6413B" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CPB9</accession>
    <name>A0A177CPB9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1160535</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG09364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039729.1">
        <property type="nucleotide sequence ID" value="XM_018177522.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CPB9"/>
    <dbReference type="STRING" id="1460663.A0A177CPB9"/>
    <dbReference type="GeneID" id="28761008"/>
    <dbReference type="InParanoid" id="A0A177CPB9"/>
    <dbReference type="OrthoDB" id="3903561at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="52"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="204"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG09364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="294" mass="33231" checksum="2A6A2D3C11C00C41" modified="2016-09-07" version="1">MKSTASSPSAPAHSSTSYEMLPTRHPSPHSPRTPNTPSNPISKKWTPSKFPWRVFTVVSSLPLALLPIVLLSALAEIASQSYLAGRDCYPNGLWKEAAGATWRIMDSSYFFTPNLSFGAMSFTQVKVIDIAWDLCVGRGGQMLLAWVNYVVFNEWLVYHMEQHRTSYKMATSVAFQTTTLGTLGVLGKEWLAFGERTWGRFWRWLAVLCMLIATLYVLAFPTLMAAMTGYITTYEPYVMDEGRSLVPWKDVRRVEYVVRDSERVGFYGGELVSATGDDELARALANCEYRRFRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CPS5</accession>
    <name>A0A177CPS5_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">EthD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1162754</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the tpcK family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039303.1">
        <property type="nucleotide sequence ID" value="XM_018178085.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CPS5"/>
    <dbReference type="STRING" id="1460663.A0A177CPS5"/>
    <dbReference type="GeneID" id="28761571"/>
    <dbReference type="InParanoid" id="A0A177CPS5"/>
    <dbReference type="OrthoDB" id="4892971at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009799">
        <property type="entry name" value="EthD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02118">
        <property type="entry name" value="EthD family reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40260">
        <property type="entry name" value="BLR8190 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40260:SF2">
        <property type="entry name" value="BLR8190 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07110">
        <property type="entry name" value="EthD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EthD" evidence="2">
        <location>
            <begin position="17"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG08938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="104" mass="11715" checksum="CFC3230DF7F4F96D" modified="2016-09-07" version="1">MPAHVSVLYPRKAKFNMDYYLATHMPLVTKHWTQHGLKKYTVTQYDDPESPYSVGCVLEFESLEEFKKAGAAPEAKEVFADIDNFSNEKPSIVAGEVKEAKSTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CQ53</accession>
    <name>A0A177CQ53_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1160522</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG09351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039716.1">
        <property type="nucleotide sequence ID" value="XM_018177519.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CQ53"/>
    <dbReference type="GeneID" id="28761005"/>
    <dbReference type="InParanoid" id="A0A177CQ53"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008058557" description="Secreted protein" evidence="1">
        <location>
            <begin position="24"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG09351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="140" mass="15261" checksum="4046D98737527DAA" modified="2016-09-07" version="1">MGRYVDSFPLFCLVLFLARITCAAVTMRWDVGGADVRTGCATRPKRQRALQQRAGYLAAGLPREAVCGAAPASERGAGVLVSSAGVLIDKATPRQRLSYPVLSFPIPLGRAPTRRKKIPTRLTWSSVSWAPFALRSRTHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CQA3</accession>
    <name>A0A177CQA3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_1162893</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG09122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039487.1">
        <property type="nucleotide sequence ID" value="XM_018178118.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CQA3"/>
    <dbReference type="GeneID" id="28761604"/>
    <dbReference type="InParanoid" id="A0A177CQA3"/>
    <dbReference type="OrthoDB" id="3767399at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="3">
        <location>
            <begin position="556"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="73"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="135"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="312"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="450"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="138"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="154"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="187"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="236"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="318"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAG09122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="644" mass="70887" checksum="83C1CD9255D14A5D" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2023-06-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CQD2</accession>
    <name>A0A177CQD2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_439433</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG09516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039881.1">
        <property type="nucleotide sequence ID" value="XM_018186284.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CQD2"/>
    <dbReference type="GeneID" id="28769770"/>
    <dbReference type="InParanoid" id="A0A177CQD2"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG09516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="159" mass="17923" checksum="E36DF3AF24FFE12F" modified="2016-09-07" version="1">MLHEGHVFKASSNLCLNECYCIQVVMLRDHSYLRPNECHATPKGLAMEISYSNSPLERNNASECKEHQPQAKVLVGCKANPRTEHVYPSNLVAQTGLKPSTCSVKQFACRGKEEVRRGASLAMAYRYAARLTRRRMVMVWKANATQTGNRSHPKCTNKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CQQ3</accession>
    <name>A0A177CQQ3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Plasma membrane ammonium transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_1137817</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acetate uptake transporter (AceTr) (TC 2.A.96) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG09844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040209.1">
        <property type="nucleotide sequence ID" value="XM_018176166.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CQQ3"/>
    <dbReference type="STRING" id="1460663.A0A177CQQ3"/>
    <dbReference type="GeneID" id="28759652"/>
    <dbReference type="InParanoid" id="A0A177CQQ3"/>
    <dbReference type="OrthoDB" id="3648309at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015123">
        <property type="term" value="F:acetate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051633">
        <property type="entry name" value="AceTr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000791">
        <property type="entry name" value="Gpr1/Fun34/SatP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31123">
        <property type="entry name" value="ACCUMULATION OF DYADS PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31123:SF4">
        <property type="entry name" value="PROTEIN ALCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01184">
        <property type="entry name" value="Gpr1_Fun34_YaaH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="65"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="93"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="124"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="165"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="193"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="230"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="8"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="24"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAG09844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="284" mass="31113" checksum="DBDE272787F5E357" modified="2016-09-07" version="1">MATNTMTTHHEPIVNDAESERITNNKPHLSHTTTNISLSPEQFERLYLAPKVPHASHNAAKYANAVPLGFLGFVISTFTFSMVLMGWGGASGLQAVVGIFFFTGPVLLLLSTIFLWIQAQFFPMMVCGLFCVFWLSFGVLQLPTLGLAASYGGGDAAVGAVSKEMNAVIALYLLVWGFALGTFWLFTIRINVVFAGIFGFVTIGSWVLSGAYWALSNGHFQKALRLQKAGAALLFIVGLLGWYMLFVIMAAEMRWRVCPPVGDLSHYWDSTDVEIGALEGEKRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CQT3</accession>
    <name>A0A177CQT3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">isopentenyl-diphosphate Delta-isomerase</fullName>
            <ecNumber evidence="4">5.3.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CC84DRAFT_1160921</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>isopentenyl diphosphate = dimethylallyl diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23284"/>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
            <dbReference type="ChEBI" id="CHEBI:128769"/>
            <dbReference type="EC" id="5.3.3.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:23285"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Isoprenoid biosynthesis; dimethylallyl diphosphate biosynthesis; dimethylallyl diphosphate from isopentenyl diphosphate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the IPP isomerase type 1 family.</text>
    </comment>
    <dbReference type="EC" id="5.3.3.2" evidence="4"/>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG09874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040239.1">
        <property type="nucleotide sequence ID" value="XM_018177616.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CQT3"/>
    <dbReference type="FunCoup" id="A0A177CQT3">
        <property type="interactions" value="784"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CQT3"/>
    <dbReference type="GeneID" id="28761102"/>
    <dbReference type="InParanoid" id="A0A177CQT3"/>
    <dbReference type="OrthoDB" id="510307at2759"/>
    <dbReference type="UniPathway" id="UPA00059">
        <property type="reaction ID" value="UER00104"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004452">
        <property type="term" value="F:isopentenyl-diphosphate delta-isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050992">
        <property type="term" value="P:dimethylallyl diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045337">
        <property type="term" value="P:farnesyl diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009240">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02885">
        <property type="entry name" value="NUDIX_IPP_Isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000012">
        <property type="entry name" value="Isopentenyl-diphosphate Delta-isomerase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011876">
        <property type="entry name" value="IsopentenylPP_isomerase_typ1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02150">
        <property type="entry name" value="IPP_isom_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10885">
        <property type="entry name" value="ISOPENTENYL-DIPHOSPHATE DELTA-ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10885:SF0">
        <property type="entry name" value="ISOPENTENYL-DIPHOSPHATE DELTA-ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 14" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="5" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0752">Steroid biosynthesis</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="13">
        <location>
            <begin position="136"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OAG09874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="316" mass="35872" checksum="C30B212FFE60DA25" modified="2016-09-07" version="1">MLQGSRSSAWFSPFYCPSPPLPPHFDAALLVSYASKSHKMSTTETLTQPAVVTQPITVAHPAITAENVQQLFPEVNTTVIGGSHASATSDNALDGYNEEQIRLMDEVCIVLDENDFPIGSATKKYAHLMENINKGLLHRAFSVFLFDSQNRLLLQQRATEKITFPDMWTNTCCSHPLGIPGETGSNLEESIEGVRRAAQRKLDQELGIKAAQVPIDDFRFLTRIHYVSPSDGKWGEHEIDYILFIKADVDLDINPNEVRDSRYVSQEDLKTMFKDPSLKFTPWFKLICESMLYEWWDHLDSGLEKYLGEQEIRRML</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CUV6</accession>
    <name>A0A177CUV6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Pisatin demethylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CC84DRAFT_1237672</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041057.1">
        <property type="nucleotide sequence ID" value="XM_018183911.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CUV6"/>
    <dbReference type="STRING" id="1460663.A0A177CUV6"/>
    <dbReference type="GeneID" id="28767397"/>
    <dbReference type="InParanoid" id="A0A177CUV6"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11058">
        <property type="entry name" value="CYP60B-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF210">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE ASQL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 7" id="KW-0349">Heme</keyword>
    <keyword evidence="5 6 7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="6">
        <location>
            <position position="456"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAG10692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="517" mass="58826" checksum="6744F30F2779CAF4" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CV36</accession>
    <name>A0A177CV36_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Tat pathway signal sequence domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CC84DRAFT_1238011</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041233.1">
        <property type="nucleotide sequence ID" value="XM_018183920.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CV36"/>
    <dbReference type="GeneID" id="28767406"/>
    <dbReference type="InParanoid" id="A0A177CV36"/>
    <dbReference type="OrthoDB" id="4798501at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045793">
        <property type="entry name" value="PcRGLX/YetA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048330">
        <property type="entry name" value="PcRGLX/YetA_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048331">
        <property type="entry name" value="PcRGLX/YetA_3rd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048329">
        <property type="entry name" value="PcRGLX_1st"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40081">
        <property type="entry name" value="CONCANAVALIN A-LIKE LECTIN/GLUCANASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40081:SF1">
        <property type="entry name" value="TAT PATHWAY SIGNAL SEQUENCE DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19501">
        <property type="entry name" value="PcRGLX_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21345">
        <property type="entry name" value="PcRGLX_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21346">
        <property type="entry name" value="PcRGLX_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008058621" description="Tat pathway signal sequence domain-containing protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="domain" description="PcRGLX/YetA-like N-terminal RIFT barrel" evidence="2">
        <location>
            <begin position="21"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="PcRGLX/YetA-like central beta-sandwich" evidence="3">
        <location>
            <begin position="117"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="domain" description="PcRGLX/YetA-like C-terminal alpha/alpha toroid" evidence="4">
        <location>
            <begin position="486"/>
            <end position="908"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF21345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF21346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAG10868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="909" mass="100692" checksum="3F4182F8DAE30054" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CVL5</accession>
    <name>A0A177CVL5_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_40872</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG11595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041960.1">
        <property type="nucleotide sequence ID" value="XM_018186082.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CVL5"/>
    <dbReference type="STRING" id="1460663.A0A177CVL5"/>
    <dbReference type="GeneID" id="28769568"/>
    <dbReference type="InParanoid" id="A0A177CVL5"/>
    <dbReference type="OrthoDB" id="5429770at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053175">
        <property type="entry name" value="DHMBA_Reg_Transcription_Factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38791">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="10"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="60"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAG11595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="483" mass="54247" checksum="6D76233EB244582A" modified="2016-09-07" version="1">MVYRGKPSESCFGCRNRRIRCDKDRSGCSQCKRMRMPCPGYPDPWEQAFRDESIKVKRKAQQTYKKKASKSKSDCNGVHRGAIPSTSNELSASFSLGLDDTQLAPSQWRLVPSIEEVALAHFMSSYIPESRFGYLPNMYAKLGRDISLLAAIDAASKARLAWEFGEPGMMEAARASYAKALTETNAALADPVTALQDATLVSVLLLSLFETMIWAGTGVPDNWVTHTQGALTLVRLRGKQQLETDVGRQLFTHVTNIISVTSLRMRQKIPQYVIELQTEATRHDDEKHPLYLVTRYTGDLANLTADIAGGKMPVDDILESTRRMDGKYLAFLENISRTWGCRTTVLDEDDPDIYGRLIHEYPRPRMAIVWNTVRMTRIFLNAIIYGHASLSTVSSAATLKAQAQRNVERMAADICASVWHFLNPKTFSAACAATLLWPLSEVRDSDLVPNDLRVYAMETLKRLARRLRMPGPLQDGLHVFYLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CXM5</accession>
    <name>A0A177CXM5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ArfGap-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_1159091</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG11600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041965.1">
        <property type="nucleotide sequence ID" value="XM_018177137.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CXM5"/>
    <dbReference type="STRING" id="1460663.A0A177CXM5"/>
    <dbReference type="GeneID" id="28760623"/>
    <dbReference type="InParanoid" id="A0A177CXM5"/>
    <dbReference type="OrthoDB" id="10266696at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08839">
        <property type="entry name" value="ArfGap_SMAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.150:FF:000010">
        <property type="entry name" value="Stromal membrane-associated protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051718">
        <property type="entry name" value="ARF_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044732">
        <property type="entry name" value="ArfGAP_SMAP1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45705">
        <property type="entry name" value="FI20236P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45705:SF1">
        <property type="entry name" value="FI20236P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00405">
        <property type="entry name" value="REVINTRACTNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50115">
        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Arf-GAP" evidence="3">
        <location>
            <begin position="16"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="155"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="157"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="170"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="201"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="217"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="288"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="313"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="365"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="427"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="464"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="510"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAG11600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="544" mass="56813" checksum="FC7663FA592DB3AB" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CXZ9</accession>
    <name>A0A177CXZ9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">CBD9-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CC84DRAFT_1211702</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042461.1">
        <property type="nucleotide sequence ID" value="XM_018182395.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CXZ9"/>
    <dbReference type="STRING" id="1460663.A0A177CXZ9"/>
    <dbReference type="GeneID" id="28765881"/>
    <dbReference type="InParanoid" id="A0A177CXZ9"/>
    <dbReference type="OrthoDB" id="19261at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd09630">
        <property type="entry name" value="CDH_like_cytochrome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08760">
        <property type="entry name" value="Cyt_b561_FRRS1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1210">
        <property type="entry name" value="Cellobiose dehydrogenase, cytochrome domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015920">
        <property type="entry name" value="Cellobiose_DH-like_cyt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006593">
        <property type="entry name" value="Cyt_b561/ferric_Rdtase_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005018">
        <property type="entry name" value="DOMON_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47797:SF1">
        <property type="entry name" value="CYTOCHROME B561 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47797">
        <property type="entry name" value="DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G05805)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16010">
        <property type="entry name" value="CDH-cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00665">
        <property type="entry name" value="B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00664">
        <property type="entry name" value="DoH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49344">
        <property type="entry name" value="CBD9-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50939">
        <property type="entry name" value="CYTOCHROME_B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50836">
        <property type="entry name" value="DOMON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012181588" evidence="9">
        <location>
            <begin position="16"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="312"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="343"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="380"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="418"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="444"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="domain" description="DOMON" evidence="10">
        <location>
            <begin position="24"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b561" evidence="11">
        <location>
            <begin position="275"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="185"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="192"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="213"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="247"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OAG12096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="498" mass="51591" checksum="5CC9A7BF1F7310AB" modified="2016-09-07" version="1">MLAAGLVALASRTAAQVASVCPTTDVCFKLNIPENTASSGNGDIFFQLSAPATYNWVALGQGSSMSGANIFVVYTAGNGNVTISPRLGTGHSMPQFNSDAQVALLEGSGVSNGKMVANVRCSSCNSWSGGSASFSGSNGNWIYATKQSGGAQDTTSQSANIDEHDNQSTFQWSYANAKGGNSVNPLVNAGSSGSGNTSGGSGGATTSCVPRQAGAVGTGTATKGTTTGGSSRATSTKSVDQDDDSSYGRSTTSPSGWTRPTARPTGNSWEGNDKRASLEERQTINYCDENDPSNTGFTPVASDGGDNSQKMLIAHGVLGALAFVIFFPAGAIAIRLASFTGVVWFHAAFQAFAYIVYIASFGLGVYIAGEEDYLSEAHPIIGIVVLVVLFFQPILGLLHHVMYKKHHARTAWSHLHLWLGRVAITLGIINGGLGLQLANDAPRAGYIAYGVIAGVVWLVWVAAIALGEKRRTRAAKDAHLANAGHPAAGHYAPKENGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CYX4</accession>
    <name>A0A177CYX4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CC84DRAFT_1108152</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042472.1">
        <property type="nucleotide sequence ID" value="XM_018175191.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CYX4"/>
    <dbReference type="STRING" id="1460663.A0A177CYX4"/>
    <dbReference type="GeneID" id="28758677"/>
    <dbReference type="InParanoid" id="A0A177CYX4"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016712">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002974">
        <property type="entry name" value="Cyt_P450_E_CYP52_ascomycetes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047146">
        <property type="entry name" value="Cyt_P450_E_CYP52_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24287">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24287:SF17">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01239">
        <property type="entry name" value="EP450IICYP52"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAG12107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="484" mass="54607" checksum="059609A04E2605D4" modified="2016-09-07" version="1" fragment="single">MGFDLLHSPTVVAGLIFTTFVVVAVFVRNEAQNRTNGFAPPVRYRALDPFMGLDYVVKLFGDISVMQRNRVQYGKTFMIKPLISPPSIVTIEPENIQRIFGSVDGDYSVFWRREPFVPFTGRGILTEDGDGWRLPRKLYRPAFAKTNIANFDFYSRMVDDFMEKIPGNGKTVDLHPLLLGAFMNNALNFTLGYDTMNPHPDAPLSRDQFESIWADGMQGIAFRILTGRLISLFPMTKFKQACRQAHQFVEFHIQQALKTNSEKNKSQVGVELLLAQTEDRTLVRNMLVQGIIGAQDTTSVLASNTIHLLARHPAIWKELREEVLRRGGDLFTFEALRSNDIIQNILSESLRLRPVFPAVDRVAVRDTTLPTGGGKDGTSPIIVKSGWRVQPAFYALHREPSVYGPNVEEFDPHRWKTIKPSQWEFMAFGGGPRNCMGREKSLVEAAYLLAKLAGKYETLEARDDKPWTGLMTFTCANKHGCLVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2023-06-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CZT8</accession>
    <name>A0A177CZT8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1159755</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042797.1">
        <property type="nucleotide sequence ID" value="XM_018177320.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CZT8"/>
    <dbReference type="GeneID" id="28760806"/>
    <dbReference type="InParanoid" id="A0A177CZT8"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG12432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="57" mass="6427" checksum="26BE7BCA3598EA6E" modified="2016-09-07" version="1">MHCARVDNVTLLSWLEQSSTDRNNSRNYDGQVRGYRGHDGAGTAFREVAPAIRNLHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CZZ0</accession>
    <name>A0A177CZZ0_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_1077212</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG13053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018043418.1">
        <property type="nucleotide sequence ID" value="XM_018173742.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CZZ0"/>
    <dbReference type="STRING" id="1460663.A0A177CZZ0"/>
    <dbReference type="GeneID" id="28757228"/>
    <dbReference type="InParanoid" id="A0A177CZZ0"/>
    <dbReference type="OrthoDB" id="5600212at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF10">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="49"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="600"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="15"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="609"/>
            <end position="619"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAG13053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="634" mass="71000" checksum="9E35EE25E9EABE2F" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177D080</accession>
    <name>A0A177D080_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">UBC-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1078313</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018043206.1">
        <property type="nucleotide sequence ID" value="XM_018173796.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177D080"/>
    <dbReference type="FunCoup" id="A0A177D080">
        <property type="interactions" value="1093"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177D080"/>
    <dbReference type="GeneID" id="28757282"/>
    <dbReference type="InParanoid" id="A0A177D080"/>
    <dbReference type="OrthoDB" id="6508832at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006301">
        <property type="term" value="P:DNA damage tolerance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd23807">
        <property type="entry name" value="UEV_UBE2V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000026">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24068">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="2">
        <location>
            <begin position="6"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG12841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="139" mass="15661" checksum="81C938B183326D7C" modified="2016-09-07" version="1">MGAKVPRNFRLLEELEKGEKGLGAEACSYGLDNGDDLLMSDWNGTILGPPHSVHENRIYSVKIHCGPNYPDLPPEISFTSKVNLPCVDQRNGKVDPTKVPCLAQWKRDFTMETILIELRRYMALPQHKKLPQPPEGSTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BUE2</accession>
    <name>A0A177BUE2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1169908</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441564">
        <property type="protein sequence ID" value="OAF98755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029121.1">
        <property type="nucleotide sequence ID" value="XM_018179785.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BUE2"/>
    <dbReference type="STRING" id="1460663.A0A177BUE2"/>
    <dbReference type="GeneID" id="28763271"/>
    <dbReference type="InParanoid" id="A0A177BUE2"/>
    <dbReference type="OrthoDB" id="10328607at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008057326" evidence="2">
        <location>
            <begin position="17"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAF98755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="211" mass="23561" checksum="3E27B39FC620DD63" modified="2016-09-07" version="1">MRSALIIAIFALTVLTAPISNLKLNDAPDIAVETRLVQARSVEKVPFLLRSEEDEQAEDEETDARSDRGKESRSVRDKSTRSAGEKEGEEDNIETRSFRGKSTRSVRGKATRSTEEDIDDEEEKEDIREVEARSVRGKASRSVRGKATRDAEAEPSVRGKASRSVRGKETRNAEHSTRTRSERSTWASGLIEALRTRGFSSATLINERQPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BVF9</accession>
    <name>A0A177BVF9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Signal recognition particle subunit SRP72</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CC84DRAFT_1191296</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the SRP72 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441562">
        <property type="protein sequence ID" value="OAF99382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029748.1">
        <property type="nucleotide sequence ID" value="XM_018181176.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BVF9"/>
    <dbReference type="FunCoup" id="A0A177BVF9">
        <property type="interactions" value="930"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177BVF9"/>
    <dbReference type="GeneID" id="28764662"/>
    <dbReference type="InParanoid" id="A0A177BVF9"/>
    <dbReference type="OrthoDB" id="5421607at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005786">
        <property type="term" value="C:signal recognition particle, endoplasmic reticulum targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000512">
        <property type="entry name" value="Signal recognition particle subunit SRP72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013699">
        <property type="entry name" value="Signal_recog_part_SRP72_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026270">
        <property type="entry name" value="SRP72"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031545">
        <property type="entry name" value="SRP72_TPR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14094">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14094:SF9">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE SUBUNIT SRP72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08492">
        <property type="entry name" value="SRP72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17004">
        <property type="entry name" value="SRP_TPR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038922">
        <property type="entry name" value="SRP72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="7 9" id="KW-0733">Signal recognition particle</keyword>
    <feature type="domain" description="Signal recognition particle SRP72 subunit RNA-binding" evidence="11">
        <location>
            <begin position="556"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="547"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="576"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="600"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="636"/>
            <end position="645"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR038922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OAF99382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="645" mass="70059" checksum="AA3ADFBD56F28B4C" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BVH2</accession>
    <name>A0A177BVH2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1169315</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441562">
        <property type="protein sequence ID" value="OAF99155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029521.1">
        <property type="nucleotide sequence ID" value="XM_018179637.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BVH2"/>
    <dbReference type="STRING" id="1460663.A0A177BVH2"/>
    <dbReference type="GeneID" id="28763123"/>
    <dbReference type="InParanoid" id="A0A177BVH2"/>
    <dbReference type="OrthoDB" id="72269at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="185"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="228"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="312"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAF99155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="354" mass="38329" checksum="A3D3D89339E19DA2" modified="2016-09-07" version="1">MVSWRNLFVSYAVMGVVALWGSMLVNGTLDAIDTAKASSELPSGRILLTSITGVPLIDGALATLVAFFDGITNGSVLQSHLLMVDLLAVIQCATIWLMVDGFSLQEFDPFVRSPASWGVGWNAIGMAVVLPVYCAFRVGTPYSRDSGLSIGDSYALFFSSAVSFVPGVLMGLPPLKSWSTHQQQVIILLYQFTPVIFSVTQMALARFINQFQYKLETNASCRTNAIRVYIVAAVGASIGHLYVMVRAISLGLLGDVFVPRPASLGRFPADRLTAGAHLFTQYDFIISALAILTWIWSQMSTYGESFGSKPTLMIASVLSTVVLGPGATLMFALWARDAYVTPLAIAEKKRSLKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BWU3</accession>
    <name>A0A177BWU3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_1222623</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441561">
        <property type="protein sequence ID" value="OAF99605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029971.1">
        <property type="nucleotide sequence ID" value="XM_018183396.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BWU3"/>
    <dbReference type="STRING" id="1460663.A0A177BWU3"/>
    <dbReference type="GeneID" id="28766882"/>
    <dbReference type="InParanoid" id="A0A177BWU3"/>
    <dbReference type="OrthoDB" id="542013at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF252">
        <property type="entry name" value="DEHYDROGENASE_REDUCTASE FAMILY PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G08550)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAF99605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="332" mass="36289" checksum="FCE652592278817E" modified="2016-09-07" version="1">MPILQASVTPLPGGICLRGQTAIVTGASNGIGTEIVLQLLEREISTVILAVRNVARGEAARTALLARPSVKKANPKAVLKVMELEVEDYASVQRFTKAFLAEHSELHLLMLNAGIGVLKRDLVSNGHEKHIQVNYLSNVLITLELLPLLNATADKTGKPTRITWTGSRMHNVSALAKGKVPLKPGESVLGHFDSEDSYVAFARYADSKLLCLLFLFELRKHLNGDKVIQNSYCPGMVNTGMSDVLPIYLRLPMNLVKAIRARSVEVAGWIALNAAVVVGPESHGQFLEDKNIVEGSPFIKTAEGQKVQKMLWNETIDELSKLTTIPGWMKKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BWU6</accession>
    <name>A0A177BWU6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_325722</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441560">
        <property type="protein sequence ID" value="OAF99872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030238.1">
        <property type="nucleotide sequence ID" value="XM_018185857.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BWU6"/>
    <dbReference type="STRING" id="1460663.A0A177BWU6"/>
    <dbReference type="GeneID" id="28769343"/>
    <dbReference type="InParanoid" id="A0A177BWU6"/>
    <dbReference type="OrthoDB" id="5402307at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="260"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="354"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="388"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="417"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAF99872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="439" mass="48439" checksum="A0C60FAC2FB487A4" modified="2016-09-07" version="1">MGVGETITVINRSGKVVSSSKHIINVFKEAKSAYRERKAEIQAERSAALHERKLRDAIKSVRLDDDTRSRASSHRSKHSHATHRSKSHRPSRPPLERGFTDSFYANDDSSPRRSRHRFEDDLAGAAQEGHRMELARRNTEAAVAVKREDPARRKSDSGIDMDLCYGEIPPPLPDKRYDEVELRDKASKITMLLDEANCLQYSVTSMIENLQKNPDALAAVALTLGEISTMVKKMGPSVLPILAKSFPAVVALLASPQFMIAGGVAVGVTIVALGGYKIVKKLQAQKEEQGHPMAMTADVGARDEPLMLDELEPPELGRIEVWRRGIADVEAESAGTSVDGEFITPGATRHLAAEGVLDEDDIRSRRSARSRKDGEHRSKSHKAKSVRSEATTKTTKTTKTAKTEKTERSSTTSRSKTVKEKSKKKEPSGLKMLFRSHSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BX02</accession>
    <name>A0A177BX02_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1222281</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441560">
        <property type="protein sequence ID" value="OAF99942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030308.1">
        <property type="nucleotide sequence ID" value="XM_018183349.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BX02"/>
    <dbReference type="GeneID" id="28766835"/>
    <dbReference type="InParanoid" id="A0A177BX02"/>
    <dbReference type="OrthoDB" id="10464817at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAF99942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="224" mass="24904" checksum="6240462E9206983A" modified="2016-09-07" version="1">MSYPNTRGPFGWTTATDSSSSEDKRRNRFNRLALASEPSNSHAEALPCGRVEAFYMQPPSRSWPVSPPRCAAEMPRVNPNYEDHRDVSPLGSPIVTHMQYRQHQSSGHGVGKNDLPFRAGVTDATSRAISAPTTPRRTYTRPDELQFPESPASEVPGSHERHVVDLLNRGANVVRAAVAFEQPVLRRQNALRKPSVSVQSPRLRFAQEVNTKEARLGLVRTGQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BX31</accession>
    <name>A0A177BX31_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ataxin-10 homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Copper transport protein 86</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CC84DRAFT_1222308</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">May play a role in the regulation of cytokinesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ataxin-10 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441560">
        <property type="protein sequence ID" value="OAF99972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030338.1">
        <property type="nucleotide sequence ID" value="XM_018183352.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BX31"/>
    <dbReference type="STRING" id="1460663.A0A177BX31"/>
    <dbReference type="GeneID" id="28766838"/>
    <dbReference type="InParanoid" id="A0A177BX31"/>
    <dbReference type="OrthoDB" id="379794at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00084">
        <property type="entry name" value="HMG-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051374">
        <property type="entry name" value="Ataxin-10/CTR86_families"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019156">
        <property type="entry name" value="Ataxin-10_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13255">
        <property type="entry name" value="ATAXIN-10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13255:SF0">
        <property type="entry name" value="ATAXIN-10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09759">
        <property type="entry name" value="Atx10homo_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="8">
        <location>
            <begin position="270"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="382"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="442"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="880"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="400"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="466"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="888"/>
            <end position="901"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00044746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00044801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAF99972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="1001" mass="112595" checksum="6186CEEC3DEA4510" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BX43</accession>
    <name>A0A177BX43_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">5-hydroxyisourate hydrolase</fullName>
            <shortName evidence="7">HIU hydrolase</shortName>
            <shortName evidence="7">HIUHase</shortName>
            <ecNumber evidence="7">3.5.2.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CC84DRAFT_1168954</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the hydrolysis of 5-hydroxyisourate (HIU) to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>5-hydroxyisourate + H2O = 5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23736"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18072"/>
            <dbReference type="ChEBI" id="CHEBI:58639"/>
            <dbReference type="EC" id="3.5.2.17"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4 7">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the transthyretin family. 5-hydroxyisourate hydrolase subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.5.2.17" evidence="7"/>
    <dbReference type="EMBL" id="KV441560">
        <property type="protein sequence ID" value="OAG00074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030439.1">
        <property type="nucleotide sequence ID" value="XM_018179539.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BX43"/>
    <dbReference type="STRING" id="1460663.A0A177BX43"/>
    <dbReference type="GeneID" id="28763025"/>
    <dbReference type="InParanoid" id="A0A177BX43"/>
    <dbReference type="OrthoDB" id="10265230at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033971">
        <property type="term" value="F:hydroxyisourate hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006144">
        <property type="term" value="P:purine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05822">
        <property type="entry name" value="TLP_HIUase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.180">
        <property type="entry name" value="Transthyretin/hydroxyisourate hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014306">
        <property type="entry name" value="Hydroxyisourate_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023418">
        <property type="entry name" value="Thyroxine_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023416">
        <property type="entry name" value="Transthyretin/HIU_hydrolase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036817">
        <property type="entry name" value="Transthyretin/HIU_hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023419">
        <property type="entry name" value="Transthyretin_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02962">
        <property type="entry name" value="hdxy_isourate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10395:SF7">
        <property type="entry name" value="5-HYDROXYISOURATE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10395">
        <property type="entry name" value="URICASE AND TRANSTHYRETIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00576">
        <property type="entry name" value="Transthyretin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49472">
        <property type="entry name" value="Transthyretin (synonym: prealbumin)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00768">
        <property type="entry name" value="TRANSTHYRETIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00769">
        <property type="entry name" value="TRANSTHYRETIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 7" id="KW-0659">Purine metabolism</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transthyretin/hydroxyisourate hydrolase" evidence="9">
        <location>
            <begin position="32"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAG00074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="158" mass="16940" checksum="3DDA5582F1A1EBFC" modified="2016-09-07" version="1">MPTPSSTAAQRLDAVSAHVSPPTMSTEKKPPITCHVLDTSLGRPASSIPVTLTLHNPPSSLSASGLTFSGTTNADGRVTSWTPSSPFSADGLDVIFKRAGDQKYSLTFDTESYFGERGVKTFFPEVEIKFVVRDGGKGEHYHVPVLLSPFGYTTYRGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BX71</accession>
    <name>A0A177BX71_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Taurine catabolism dioxygenase TauD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CC84DRAFT_1169246</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441561">
        <property type="protein sequence ID" value="OAF99735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030101.1">
        <property type="nucleotide sequence ID" value="XM_018179612.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BX71"/>
    <dbReference type="STRING" id="1460663.A0A177BX71"/>
    <dbReference type="GeneID" id="28763098"/>
    <dbReference type="InParanoid" id="A0A177BX71"/>
    <dbReference type="OrthoDB" id="272271at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.130.10:FF:000009">
        <property type="entry name" value="Putative Taurine catabolism dioxygenase TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050411">
        <property type="entry name" value="AlphaKG_dependent_hydroxylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696">
        <property type="entry name" value="GAMMA-BUTYROBETAINE HYDROXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696:SF56">
        <property type="entry name" value="TAUD_TFDA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0045">Antibiotic biosynthesis</keyword>
    <keyword evidence="5" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="4">
        <location>
            <begin position="101"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="375"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAF99735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="404" mass="45442" checksum="6F20F8F0610B559A" modified="2016-09-07" version="1">MAPALTAHTPTAPHELGAKKAFLNHEAPRHIYPDGIKTSGQHPPLYNQLHPYEDFPTEIAGPTVWNVEEYKGHPEQWTHVFSDAEIKEISDTADAFIASGTPLTGISQETFRLNNFAQFLSVLRKELIDGKGFILFKGLPVQQWGNHKSAVAYMGLGTHLGYFVSQNAHGHVLGHVKDLGEDSSAIDRVRIYRTNARQFFHADDADLVGLLCIAKALEGGESDLVSSHAVWNALQKENPDVARTLTEPIWYFDRKGEKSVGEEDWIRTSVFYLEKGANPRVYSKWDPYYIRSLTRFSDKGLIPPLSDAQQRATTVLEETCQRLALHMILEVGDIQFLSNNHILHARTAYKDFAPPAPRRHLMRLWLSTPEEEGGWKLPFHDSKEKKRGGIQVNDNPPVAPLDAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BXY1</accession>
    <name>A0A177BXY1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_385147</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441562">
        <property type="protein sequence ID" value="OAF99189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029555.1">
        <property type="nucleotide sequence ID" value="XM_018185997.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BXY1"/>
    <dbReference type="GeneID" id="28769483"/>
    <dbReference type="InParanoid" id="A0A177BXY1"/>
    <dbReference type="OrthoDB" id="10261408at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053187">
        <property type="entry name" value="Notoamide_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47256:SF1">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47256">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="33"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="218"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="220"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAF99189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="296" mass="32927" checksum="5C33E70B1FD02FBD" modified="2016-09-07" version="1">MRPFRPLLPAKRGFEEPQPTPPEAPLKKRSTLACDSCRGKRIKCNGARPTCDACSQRSLACHYHERRSRNSQEDEAARKRESIVEMFLLLIKSGTEEHALGVVRSLRAGSSIEAIVSQPGPGEESVFPQLGYGTPGLPIATSVQSESSLTEAETETSHAAFQGADSLLQREYDALAKRVETLQEMLDLLRSMPENDAQRLLRELRSASEVDSVLRATNTHGHDTRPTEQRHARSLPPSLHGNRELELSMLYPRVFPTMERFHDVGIVPGLTGGMTDVNVQDPWTTDPVNVWELPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BYC6</accession>
    <name>A0A177BYC6_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_1129779</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441560">
        <property type="protein sequence ID" value="OAF99950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030316.1">
        <property type="nucleotide sequence ID" value="XM_018175841.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BYC6"/>
    <dbReference type="GeneID" id="28759327"/>
    <dbReference type="InParanoid" id="A0A177BYC6"/>
    <dbReference type="OrthoDB" id="3918601at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39614">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39614:SF2">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="23"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="62"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="106"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="136"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="177"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="213"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="3">
        <location>
            <begin position="44"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="314"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="420"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="560"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="314"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="354"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="364"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="384"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="426"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="566"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="619"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="650"/>
            <end position="663"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAF99950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="707" mass="77691" checksum="FC9117BA6F1D93BB" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BZ28</accession>
    <name>A0A177BZ28_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="8">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CC84DRAFT_1168855</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the tannase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="8"/>
    <dbReference type="EMBL" id="KV441560">
        <property type="protein sequence ID" value="OAF99948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030314.1">
        <property type="nucleotide sequence ID" value="XM_018179502.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BZ28"/>
    <dbReference type="STRING" id="1460663.A0A177BZ28"/>
    <dbReference type="GeneID" id="28762988"/>
    <dbReference type="InParanoid" id="A0A177BZ28"/>
    <dbReference type="OrthoDB" id="3039123at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030600">
        <property type="term" value="F:feruloyl esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011118">
        <property type="entry name" value="Tannase/feruloyl_esterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33938:SF8">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33938">
        <property type="entry name" value="FERULOYL ESTERASE B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07519">
        <property type="entry name" value="Tannase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="4 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007948921" description="Carboxylic ester hydrolase" evidence="8">
        <location>
            <begin position="19"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="530"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="541"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAF99948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="578" mass="63258" checksum="199C983B8F9ED550" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2023-06-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BZC8</accession>
    <name>A0A177BZC8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1180524</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441559">
        <property type="protein sequence ID" value="OAG00516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030881.1">
        <property type="nucleotide sequence ID" value="XM_018180481.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BZC8"/>
    <dbReference type="GeneID" id="28763967"/>
    <dbReference type="InParanoid" id="A0A177BZC8"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG00516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="154" mass="16636" checksum="6DFCC686F245F2CF" modified="2016-09-07" version="1">MQPGNNVSTMPPTANQYSAPCCRALFETGRGCSRLLVPSTAASSSHKGAGSGRRVVAPRSSPLGHLRAHQQPCLHLPQWQKRCYQTVSNDSHACTQTAPLRASSRARRLYRAAGLSRHAAVQRESEAALRVSAAMASRLQFAARKCTKRLQPCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BZU0</accession>
    <name>A0A177BZU0_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">diacylglycerol O-acyltransferase</fullName>
            <ecNumber evidence="5">2.3.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CC84DRAFT_1168598</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>an acyl-CoA + a 1,2-diacyl-sn-glycerol = a triacyl-sn-glycerol + CoA</text>
            <dbReference type="Rhea" id="RHEA:10868"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:64615"/>
            <dbReference type="EC" id="2.3.1.20"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Glycerolipid metabolism; triacylglycerol biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the diacylglycerol acyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.20" evidence="5"/>
    <dbReference type="EMBL" id="KV441559">
        <property type="protein sequence ID" value="OAG00501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030866.1">
        <property type="nucleotide sequence ID" value="XM_018179439.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BZU0"/>
    <dbReference type="FunCoup" id="A0A177BZU0">
        <property type="interactions" value="221"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177BZU0"/>
    <dbReference type="GeneID" id="28762925"/>
    <dbReference type="InParanoid" id="A0A177BZU0"/>
    <dbReference type="OrthoDB" id="264532at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004144">
        <property type="term" value="F:diacylglycerol O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006071">
        <property type="term" value="P:glycerol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019432">
        <property type="term" value="P:triglyceride biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07987">
        <property type="entry name" value="LPLAT_MGAT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007130">
        <property type="entry name" value="DAGAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12317:SF0">
        <property type="entry name" value="ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12317">
        <property type="entry name" value="DIACYLGLYCEROL O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03982">
        <property type="entry name" value="DAGAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14 18" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0319">Glycerol metabolism</keyword>
    <keyword evidence="6" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 18" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="199"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="130"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="36"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="59"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="91"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="OAG00501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="517" mass="58642" checksum="DFF76BC6D20EA77A" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BZX1</accession>
    <name>A0A177BZX1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1222330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441560">
        <property type="protein sequence ID" value="OAF99996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030362.1">
        <property type="nucleotide sequence ID" value="XM_018183357.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BZX1"/>
    <dbReference type="GeneID" id="28766843"/>
    <dbReference type="InParanoid" id="A0A177BZX1"/>
    <dbReference type="OrthoDB" id="4829316at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAF99996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="75" mass="8474" checksum="6B3BDD4705753F0A" modified="2016-09-07" version="1">MPSPTQKFAMFRTAARYLTEPHPFARNPVTIKPHPVDFSLYPKRLARTGAFVFPMALVVLGWPVAAEIYGRRVGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C046</accession>
    <name>A0A177C046_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1209275</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441559">
        <property type="protein sequence ID" value="OAG00269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030634.1">
        <property type="nucleotide sequence ID" value="XM_018182210.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C046"/>
    <dbReference type="STRING" id="1460663.A0A177C046"/>
    <dbReference type="GeneID" id="28765696"/>
    <dbReference type="InParanoid" id="A0A177C046"/>
    <dbReference type="OrthoDB" id="3685818at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="285"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="435"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="214"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="285"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="349"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG00269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="754" mass="83515" checksum="92A98EFCE3860802" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C0Y0</accession>
    <name>A0A177C0Y0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">TrkH-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CC84DRAFT_1263118</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441558">
        <property type="protein sequence ID" value="OAG01076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031441.1">
        <property type="nucleotide sequence ID" value="XM_018185209.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C0Y0"/>
    <dbReference type="STRING" id="1460663.A0A177C0Y0"/>
    <dbReference type="GeneID" id="28768695"/>
    <dbReference type="InParanoid" id="A0A177C0Y0"/>
    <dbReference type="OrthoDB" id="9999863at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140107">
        <property type="term" value="F:high-affinity potassium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030007">
        <property type="term" value="P:intracellular potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990573">
        <property type="term" value="P:potassium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003445">
        <property type="entry name" value="Cat_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051143">
        <property type="entry name" value="TrkH_K-transport"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31064">
        <property type="entry name" value="POTASSIUM TRANSPORT PROTEIN DDB_G0292412-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31064:SF37">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02386">
        <property type="entry name" value="TrkH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="42"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="66"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="306"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="349"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="380"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="448"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="513"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="691"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="166"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="167"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="185"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAG01076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="775" mass="85792" checksum="3798298D8ED012E0" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C1M7</accession>
    <name>A0A177C1M7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Amidohydrolase-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1154047</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-dependent hydrolases superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV441558">
        <property type="protein sequence ID" value="OAG00779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031144.1">
        <property type="nucleotide sequence ID" value="XM_018176865.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C1M7"/>
    <dbReference type="STRING" id="1460663.A0A177C1M7"/>
    <dbReference type="GeneID" id="28760351"/>
    <dbReference type="InParanoid" id="A0A177C1M7"/>
    <dbReference type="OrthoDB" id="2135488at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052350">
        <property type="entry name" value="Metallo-dep_Lactonases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43569">
        <property type="entry name" value="AMIDOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43569:SF2">
        <property type="entry name" value="AMIDOHYDROLASE-RELATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="2">
        <location>
            <begin position="204"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG00779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="363" mass="40297" checksum="163B40BC109B5CBA" modified="2016-09-07" version="1">MPPTILDSHIHLWPSTATSSQDHAWMTPGLFLARRHGVHDYAAATAAAPVQPAGFVYVETDRYLPSASLSLDAGAGDEEVEEKLSAWARAPLEELAFLRRVVEGDVQEGDGASEGDGEQMKGLVIWAPFHVQERVFGTYLRVARERLGEKAWARVVGFRYLLQGRTADEVKSIIGNEWFVSNVKLACEKGERRLAFDVGVDAHRDGIEALEAVAALIEGVEEGVNFVLNHLCKPDLSTPTWPFFPRWQACIGRLSSHPNVYMKLSGALNEFAPSATPSSVETVLDTLRPYLDYVLQSFGAHRVLFGSDWPVCNVGGPKGEVGNWGFWVEVVERYWEEKELSEKDIEWVWAKSAAAAYGIKELR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C282</accession>
    <name>A0A177C282_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Opioid growth factor receptor (OGFr) conserved domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_201236</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the opioid growth factor receptor family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441557">
        <property type="protein sequence ID" value="OAG01556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031921.1">
        <property type="nucleotide sequence ID" value="XM_018185568.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C282"/>
    <dbReference type="STRING" id="1460663.A0A177C282"/>
    <dbReference type="GeneID" id="28769054"/>
    <dbReference type="InParanoid" id="A0A177C282"/>
    <dbReference type="OrthoDB" id="9030204at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140625">
        <property type="term" value="F:opioid growth factor receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006757">
        <property type="entry name" value="OGF_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039574">
        <property type="entry name" value="OGFr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14015:SF2">
        <property type="entry name" value="OPIOID GROWTH FACTOR RECEPTOR (OGFR) CONSERVED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14015">
        <property type="entry name" value="OPIOID GROWTH FACTOR RECEPTOR OGFR ZETA-TYPE OPIOID RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04664">
        <property type="entry name" value="OGFr_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Opioid growth factor receptor (OGFr) conserved" evidence="3">
        <location>
            <begin position="13"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="Opioid growth factor receptor (OGFr) conserved" evidence="3">
        <location>
            <begin position="173"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="113"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="113"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAG01556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="265" mass="29823" checksum="8831281E3806EEEB" modified="2016-09-07" version="1">MSLRGQPPSIVDFYNPYINAKDAHGRTREQILKWNNDKLERSHDYIQILFPLPEGSMFSYTAPIIDKKTVEEFRTNGHLQTTLGQAFDRMMRFYGFEVVSALDSADSAKQAEECAAAEEKGKGKAAEGEEHDEGRNGSAGTTASLDVDPSVPSAHDTKLPEKSVASSGVHHLRVIRGVNFEERSKNWCVQMDHNHLRISRILRSLRVLGLQRQCEAFFEALTNVYNDPKTTIGKSSMMFWRRAVCEPLHIAPDGTECKWLKALAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C2H8</accession>
    <name>A0A177C2H8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CC84DRAFT_205672</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ORC5 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441557">
        <property type="protein sequence ID" value="OAG01646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032011.1">
        <property type="nucleotide sequence ID" value="XM_018185587.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C2H8"/>
    <dbReference type="FunCoup" id="A0A177C2H8">
        <property type="interactions" value="821"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177C2H8"/>
    <dbReference type="GeneID" id="28769073"/>
    <dbReference type="InParanoid" id="A0A177C2H8"/>
    <dbReference type="OrthoDB" id="365981at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005664">
        <property type="term" value="C:nuclear origin of replication recognition complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020796">
        <property type="entry name" value="ORC5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047088">
        <property type="entry name" value="ORC5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048866">
        <property type="entry name" value="ORC5_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12705">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12705:SF0">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14630">
        <property type="entry name" value="ORC5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21639">
        <property type="entry name" value="ORC5_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Orc1-like AAA ATPase" evidence="7">
        <location>
            <begin position="15"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="ORC5 lid" evidence="9">
        <location>
            <begin position="225"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="Origin recognition complex subunit 5 C-terminal" evidence="8">
        <location>
            <begin position="329"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF14630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF21639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAG01646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="476" mass="53338" checksum="84419FA2BF92FC6B" modified="2016-09-07" version="1">MLPDEILEQLNSEYPCRESQIQQLAALYNAHLPSPSLLVAHGLTATGKSSIIRSYLELSSLPYAFANSRECITGRHLLERTVASCLDALDGYYDETIDRRPYSRTENLSSLIVALGRMLEGRGKFVLVLDGIDKQREAPYTLLPALARFGESIPNLSIILITTLPIPLELHRPGTPHLHFPTYNRNSLLTILGKSPPKIFLQPPNEEQFPDYTPDLAAEDDAWLWGRFIATVYDALSRHTGRDFVSFRLAAMRLWRPFVEPIVQGTFGTRDYSRLMVNRRALFQVEDSVLDRIIAGNSNLGANINGTNGSVVPMTPSTRRKTRTIAHDLPYYTTHLLIAAYLASYNPSRTDVTYFMKHTDKRKNKRRAPSVTAGVTKSKHRKISRHLLTPSPFSLDRLLAIFRSLLVESVPQVADLYTQIATLTSMRLLVRTGGVGSSDVLDPAAKWRVNFGWEYARSLGRGVNLEVGEYLVGGVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C340</accession>
    <name>A0A177C340_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CC84DRAFT_1074571</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441556">
        <property type="protein sequence ID" value="OAG01885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032250.1">
        <property type="nucleotide sequence ID" value="XM_018173700.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C340"/>
    <dbReference type="STRING" id="1460663.A0A177C340"/>
    <dbReference type="GeneID" id="28757186"/>
    <dbReference type="InParanoid" id="A0A177C340"/>
    <dbReference type="OrthoDB" id="3366823at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11040">
        <property type="entry name" value="CYP7_CYP8-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053007">
        <property type="entry name" value="CYP450_monoxygenase_sec-met"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47582">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47582:SF1">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0349">Heme</keyword>
    <keyword evidence="4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="259"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="418"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAG01885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="442" mass="48325" checksum="64C6D583ED6A31AA" modified="2016-09-07" version="1" fragment="single">PDEPPLIPHLYLPFLGHVIGMFWHGASYFARVNAATQYPIYTLLTLTGRTIVVTDPALAGTIQKASKNTSFYGMILEVTKRLVDLDEPTMEIIRWNINGEHGPHEGLMHEAGSMVAGELSPGPSLNEMSTAQLQQFATLLDVFVSSPAGVEISLMEFVKRIFTVANAFAIYGPQNPFALTPSLVHDFWTWESGMTAVMANIFPSLTARKPYLAREAINAALQDFVAKEHYRAASAMIQKRVQINLKHGLSHKMAGHAELILLFGIVGNAVPTTFWVLANIFSRPELLARIREETSKAVICPRSNPGSPREKVISVAQLKATCPLLVSTYRETIRSVANLSSVRLVVHTHTVSAPGHRPYLLRKGAMVQIASGVIHALRAVWGPDAGEFNPSRFMSATTSTEQFSSAAYRGFGGGSIICPGRHFAQNEILGFVALCVHTLEVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C416</accession>
    <name>A0A177C416_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1167744</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441557">
        <property type="protein sequence ID" value="OAG01538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031903.1">
        <property type="nucleotide sequence ID" value="XM_018179252.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C416"/>
    <dbReference type="STRING" id="1460663.A0A177C416"/>
    <dbReference type="GeneID" id="28762738"/>
    <dbReference type="InParanoid" id="A0A177C416"/>
    <dbReference type="OrthoDB" id="3946750at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="294"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="525"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1159"/>
            <end position="1183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1213"/>
            <end position="1236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="224"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="315"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="362"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="527"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="537"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1213"/>
            <end position="1233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG01538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="1267" mass="140435" checksum="B5EE9F9DAF61C8C1" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C435</accession>
    <name>A0A177C435_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Fork-head domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CC84DRAFT_1098497</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441556">
        <property type="protein sequence ID" value="OAG02166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032531.1">
        <property type="nucleotide sequence ID" value="XM_018174773.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C435"/>
    <dbReference type="STRING" id="1460663.A0A177C435"/>
    <dbReference type="GeneID" id="28758259"/>
    <dbReference type="InParanoid" id="A0A177C435"/>
    <dbReference type="OrthoDB" id="5954824at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001766">
        <property type="entry name" value="Fork_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030456">
        <property type="entry name" value="TF_fork_head_CS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45881">
        <property type="entry name" value="CHECKPOINT SUPPRESSOR 1-LIKE, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45881:SF5">
        <property type="entry name" value="FORK-HEAD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00250">
        <property type="entry name" value="Forkhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00339">
        <property type="entry name" value="FH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00658">
        <property type="entry name" value="FORK_HEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50039">
        <property type="entry name" value="FORK_HEAD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Fork-head" evidence="8">
        <location>
            <begin position="78"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Fork-head" evidence="6">
        <location>
            <begin position="78"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="166"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="309"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="50"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="168"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="198"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="217"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="316"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAG02166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="384" mass="42820" checksum="846C9C09C97C458A" modified="2016-09-07" version="1">MTSFPPPLYQMGPQQPYEDMDLSHSPNNNLMQLDTEYGDYPRPIPEDVTAYSTPYNSSRSSTPNEESPLLPHDDGVFDKDRPYAQLIFDALKQAPNHTMILRDIYDWFRKNTDKALDKDTKGWQNSIRHNLSMNGAFEKVDQPFEEAKKGFMWKLTQDALANGVKSTTRYRSKQPNKRGHRTSHYLQRQRAGAVGGRSAKKQLRHRARMHDAYRSDPYQTSSRSMPTPATFDSSFFSDISGFEMYPSSPSFYSPSGSEIDAMEYQPNAYGTASEQRMSQQIFHDLPSAPVSSSSLASYSDGYIKLPSDPAMPLFTRSPTDTPSPSASEPRTPDSQSPGWDDSIYGPMGGPGHAGFDLNGFGIGIAGTSSMPNDQFAHDSLVNGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C461</accession>
    <name>A0A177C461_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">lytic cellulose monooxygenase (C4-dehydrogenating)</fullName>
            <ecNumber evidence="15">1.14.99.56</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CC84DRAFT_1006473</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>[(1-&gt;4)-beta-D-glucosyl]n+m + reduced acceptor + O2 = 4-dehydro-beta-D-glucosyl-[(1-&gt;4)-beta-D-glucosyl]n-1 + [(1-&gt;4)-beta-D-glucosyl]m + acceptor + H2O.</text>
            <dbReference type="EC" id="1.14.99.56"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the polysaccharide monooxygenase AA9 family.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.56" evidence="15"/>
    <dbReference type="EMBL" id="KV441556">
        <property type="protein sequence ID" value="OAG02196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032561.1">
        <property type="nucleotide sequence ID" value="XM_018173339.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C461"/>
    <dbReference type="GeneID" id="28756825"/>
    <dbReference type="InParanoid" id="A0A177C461"/>
    <dbReference type="OrthoDB" id="6038816at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049892">
        <property type="entry name" value="AA9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005103">
        <property type="entry name" value="AA9_LPMO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353:SF10">
        <property type="entry name" value="ENDO-BETA-1,4-GLUCANASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03443">
        <property type="entry name" value="AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="8" id="KW-0186">Copper</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 16" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008057686" description="lytic cellulose monooxygenase (C4-dehydrogenating)" evidence="16">
        <location>
            <begin position="21"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="Auxiliary Activity family 9 catalytic" evidence="17">
        <location>
            <begin position="21"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00045077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF03443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="OAG02196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="300" mass="33220" checksum="D1315FC8DFA9B5AC" modified="2016-09-07" version="1">MAKTTFIPVALLTLLHSAAAHYYFPHLIVNGTITPEFKYVRDVRPHEGDYSDPDGYNGKEYPVYGEFEDTYMTDVRCGRDAFAYGAAKTDTATIVAGSAVGFHIKVRFHLLHSRTPFRIYTPCGTFANTSGTQEFVDPQYNNGIFHPGPAQVYMSASADPAKDDGSGDWFKIYYLGPSSNTTWATDRATQINFTIPLATPPGPYLLRLELPFPIKDWPGHSQWYVNCAHVNIVGDGTGTPGPTIRIPDDYTSYDEGIGLTTPGVDFDTGLDWYVPPGPALWTGEEGSEKRAVEEGWRREV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C4D6</accession>
    <name>A0A177C4D6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Galactose mutarotase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_1096875</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldose epimerase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG02604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032969.1">
        <property type="nucleotide sequence ID" value="XM_018174688.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C4D6"/>
    <dbReference type="FunCoup" id="A0A177C4D6">
        <property type="interactions" value="747"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177C4D6"/>
    <dbReference type="GeneID" id="28758174"/>
    <dbReference type="InParanoid" id="A0A177C4D6"/>
    <dbReference type="OrthoDB" id="274691at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004034">
        <property type="term" value="F:aldose 1-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033499">
        <property type="term" value="P:galactose catabolic process via UDP-galactose, Leloir pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09019">
        <property type="entry name" value="galactose_mutarotase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.98.10:FF:000015">
        <property type="entry name" value="Aldose 1-epimerase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018052">
        <property type="entry name" value="Ald1_epimerase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008183">
        <property type="entry name" value="Aldose_1/G6P_1-epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047215">
        <property type="entry name" value="Galactose_mutarotase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10091">
        <property type="entry name" value="ALDOSE-1-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10091:SF0">
        <property type="entry name" value="GALACTOSE MUTAROTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01263">
        <property type="entry name" value="Aldose_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00545">
        <property type="entry name" value="ALDOSE_1_EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAG02604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="332" mass="36521" checksum="35FA00FBE86FEC97" modified="2016-09-07" version="1">MSTDKAFTFLPLGAIIQEFKVAGKNIVQGFSTAEHYKSHNAPYFGETIGRIANRTAHGKFELNGQTYQLPVNNGPNSLHGGNLGWGKCEFEGPFAVDRNGKQATLFKYLSKHGEEGYPGTVEVRVWYVQEKLNEDGYQKEVLHIEYEAELVGDDAPATAINITNHSYFNLSGSSTIAGTEATLITNKYQVVDDGGIPTGPIEDYPGVNPNSSFTLGEKEPDIDDCFVVNTNPASVPLDTRDSALQTVASFFHPESRIHLEVATTEPAFQFYTGKYIDVPAVESLPARGARSAFCVEPSRYVNAINVPEYRSMTILKKGEIYGSKIVYRGWKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C4P8</accession>
    <name>A0A177C4P8_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NAD dependent epimerase/dehydratase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1261423</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG02714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033079.1">
        <property type="nucleotide sequence ID" value="XM_018185061.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C4P8"/>
    <dbReference type="STRING" id="1460663.A0A177C4P8"/>
    <dbReference type="GeneID" id="28768547"/>
    <dbReference type="InParanoid" id="A0A177C4P8"/>
    <dbReference type="OrthoDB" id="408152at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040632">
        <property type="entry name" value="Sulfotransfer_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36978:SF8">
        <property type="entry name" value="NAD DEPENDENT EPIMERASE_DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36978">
        <property type="entry name" value="P-LOOP CONTAINING NUCLEOTIDE TRIPHOSPHATE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17784">
        <property type="entry name" value="Sulfotransfer_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="269"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG02714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="292" mass="33483" checksum="73F00DEB67821D5F" modified="2016-09-07" version="1">MVSLSSPTWRVIESFYESFAPNPPPRIRDPARPMQVICVGLPRSGTESLQKALLTLGYDYTYHGWDMLNESPHRMNAWVALARRKFFAPTAEPITSTDFDALLGHAVAVTDAAANCFAAEMIAAYPDAKVILNMRRDLDAWHSSVLSNIVAVNEDWFKWLLCWFNADLWWQWHIHQRILWPALFRCTDYRSLRSGVEPFGKTVHEQHSATIRRLVPQERLLEWHIEDGWGPLCEFLEKEVPVTPFPRANDKGAFTKRVETDLEALGRSAFMNMILAFLGVTTVFGSLLFTNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C4Q1</accession>
    <name>A0A177C4Q1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_214738</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441557">
        <property type="protein sequence ID" value="OAG01707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032072.1">
        <property type="nucleotide sequence ID" value="XM_018185605.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C4Q1"/>
    <dbReference type="GeneID" id="28769091"/>
    <dbReference type="InParanoid" id="A0A177C4Q1"/>
    <dbReference type="OrthoDB" id="3793524at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG01707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="407" mass="46531" checksum="43D0339F04814C94" modified="2016-09-07" version="1">MTTYFYHHPDGFEYSHVLPNVAPVYLATALVPGSALESYWQSMGTQATASSITPDDSQDEYGATGGDKWHETDESYYSNNSDNTLRASYFGDPFAGSGQHGMTGPNPPIFAQSDGEYFKYPFPELIRPYHTLHSLLPYLQPARLENSVFGPKLDIVEEDTDYKFAVAVPKKMLVLFCGRNIVNRFLRTLEREDNVNWQGLPVAQELRFPRHYTNHVGVKIMISWMHRACITPKKDMRPIRVPKNTFAALSLSRALTAFGLHRDASRVDHTIATKHFKRWLGFDNIVSIWNCLPKDSKYVYRMVEDLRNQLDQYASGDTKALPDADKVLEFLEQHPELLHRIHDKEYNDRQELRPFFGTEWCERAALRTQQMIAGLMDTRGDETSMPVEWGGGFNATNLRPNLRGGNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C4S6</accession>
    <name>A0A177C4S6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">4-carboxymuconolactone decarboxylase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1098586</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441556">
        <property type="protein sequence ID" value="OAG02426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032791.1">
        <property type="nucleotide sequence ID" value="XM_018174777.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C4S6"/>
    <dbReference type="GeneID" id="28758263"/>
    <dbReference type="InParanoid" id="A0A177C4S6"/>
    <dbReference type="OrthoDB" id="9998495at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051920">
        <property type="term" value="F:peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1290.10">
        <property type="entry name" value="AhpD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029032">
        <property type="entry name" value="AhpD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003779">
        <property type="entry name" value="CMD-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34846">
        <property type="entry name" value="4-CARBOXYMUCONOLACTONE DECARBOXYLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G11590)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34846:SF11">
        <property type="entry name" value="4-CARBOXYMUCONOLACTONE DECARBOXYLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G11590)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02627">
        <property type="entry name" value="CMD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69118">
        <property type="entry name" value="AhpD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carboxymuconolactone decarboxylase-like" evidence="1">
        <location>
            <begin position="44"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG02426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="196" mass="21273" checksum="F7487B94990A311C" modified="2016-09-07" version="1">MRVPYAPKEPPTEEDKPVYERIAARRAPRPLIPLDLALLHNTAVADGWNSFIGAIRTKTSVADSLKELAIARVAVINHAVHEWDVHAALALKGGISKEGLETAYTAELVKKGDKVDFAEKGGLTKEQWVVLAYTDQMTVGVEVDDGVAGALREVLGDKQVVELTATIAAYNCVSRFLVALDVGECNGRPMKKVEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C5Q7</accession>
    <name>A0A177C5Q7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CC84DRAFT_1124813</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Is probably involved in a pathway contributing to genomic integrity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the IRC22 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG02845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033210.1">
        <property type="nucleotide sequence ID" value="XM_018175700.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C5Q7"/>
    <dbReference type="GeneID" id="28759186"/>
    <dbReference type="InParanoid" id="A0A177C5Q7"/>
    <dbReference type="OrthoDB" id="1926781at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005595">
        <property type="entry name" value="TRAP_alpha"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12924:SF0">
        <property type="entry name" value="TRANSLOCON-ASSOCIATED PROTEIN SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12924">
        <property type="entry name" value="TRANSLOCON-ASSOCIATED PROTEIN, ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03896">
        <property type="entry name" value="TRAP_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0732">Signal</keyword>
    <keyword evidence="2 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008057850" evidence="11">
        <location>
            <begin position="22"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="172"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="201"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="254"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OAG02845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="274" mass="29675" checksum="FC3F9B49DF621B6A" modified="2016-09-07" version="1">MIAWKLSTLFLSSLCALNAFAAIEVENVEEVVGEQPQTPNLKVSISASFPQSEIFGVKLINGHATQARLSIDNQEPEAVTVQIVGGSLIKDAGDQTQILRNLTGQRYGLEIPGGEEQTLTYSFATEMHPQDVRLQLVAVIQDKKNAFYTISAYNETVSIVEAPTSIFDPQIIFLYLVLLGAFAGTVYFIYNTWITTLFPQQKRGGKGGERAKKSSGGSKKVDPSEQVAVVGADGPAVAATGSKTYDASWIPAQHLQRPEAKRVRSGTPKTKVKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C612</accession>
    <name>A0A177C612_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1166653</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG02846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033211.1">
        <property type="nucleotide sequence ID" value="XM_018179014.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C612"/>
    <dbReference type="STRING" id="1460663.A0A177C612"/>
    <dbReference type="GeneID" id="28762500"/>
    <dbReference type="InParanoid" id="A0A177C612"/>
    <dbReference type="OrthoDB" id="3512845at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057683">
        <property type="entry name" value="DUF7923"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057654">
        <property type="entry name" value="Znf-CCCH_tandem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37543">
        <property type="entry name" value="CCCH ZINC FINGER DNA BINDING PROTEIN (AFU_ORTHOLOGUE AFUA_5G12760)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37543:SF1">
        <property type="entry name" value="CCCH ZINC FINGER DNA BINDING PROTEIN (AFU_ORTHOLOGUE AFUA_5G12760)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25540">
        <property type="entry name" value="DUF7923"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25543">
        <property type="entry name" value="zf-CCCH_tandem"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="2">
        <location>
            <begin position="414"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="1">
        <location>
            <begin position="414"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG02846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="519" mass="57651" checksum="24EFD9706B6FFF77" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C646</accession>
    <name>A0A177C646_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Crh-like protein</fullName>
            <ecNumber evidence="15">3.2.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">CC84DRAFT_1098882</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Dual chitinase/transglycosylase that plays a role in cell wall architecture. Chitinase and transglycosylase activities are coupled. Required for the polysaccharide cross-linking at the septa and the cell wall. More specifically, transfers chitin to 1,6-beta-glucan in the cell wall.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the glycosyl hydrolase 16 family. CRH1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.2.-.-" evidence="15"/>
    <dbReference type="EMBL" id="KV441556">
        <property type="protein sequence ID" value="OAG02160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032525.1">
        <property type="nucleotide sequence ID" value="XM_018174794.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C646"/>
    <dbReference type="FunCoup" id="A0A177C646">
        <property type="interactions" value="384"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177C646"/>
    <dbReference type="GeneID" id="28758280"/>
    <dbReference type="InParanoid" id="A0A177C646"/>
    <dbReference type="OrthoDB" id="4781at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02183">
        <property type="entry name" value="GH16_fungal_CRH1_transglycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000159">
        <property type="entry name" value="Glycosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017168">
        <property type="entry name" value="CHR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF22">
        <property type="entry name" value="GLYCOSIDASE CRH2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00722">
        <property type="entry name" value="Glyco_hydro_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037299">
        <property type="entry name" value="Glycosidase_CRH1_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="7 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="8 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 18" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008057864" description="Crh-like protein" evidence="18">
        <location>
            <begin position="22"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="19">
        <location>
            <begin position="60"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="339"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="343"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="374"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="17">
        <location>
            <begin position="414"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="16">
        <location>
            <position position="161"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="16">
        <location>
            <position position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00093308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRNR" id="PIRNR037299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR037299-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="OAG02160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="462" mass="47759" checksum="008B88926EF57691" modified="2016-09-07" version="1">MVRHAFTAAVAAAAVVGSAFAQKCTRQSKCPKDTPCCGLYGDCGVGAFCLGGCDPTMSTTFDSCVPNPICKSNTYQFTDLNDIQSIDKYLGDNSKINWQAQGNPVKYPSGGVALTMAEGTVGTLLASTFYVWYGKICATMSTSRGQGVVTAFIMMSDVKDEIDFEFIGNDINNAQSNWYSQGVTNYENMEKLKVSPDTVGDTHEYCIDWSEDELSWSVDGNKGRTVKRTDSWNATAGRFDFPQTPSRVMLSLWPAGLPSNGEGTIEWAGGEIDWNSKYMTNGMYAALVTKVTVDCYDPPSGIKSTGSKSYKYTSNMPTNNTVEITNDFVVLGSLMDTGDEPGSTASASKSSSAAKSTKSVNMVPGGNPGGGARQETAVAAQNTAQATSGSSSTGSSGSSGSGDSGSSGSSSGSSTGGGFVQGDGNSGSSGTGSGAAALEPGLAKIGGSAIAIVFAVFGLLVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C663</accession>
    <name>A0A177C663_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7820 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1207791</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG03015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033380.1">
        <property type="nucleotide sequence ID" value="XM_018182121.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C663"/>
    <dbReference type="STRING" id="1460663.A0A177C663"/>
    <dbReference type="GeneID" id="28765607"/>
    <dbReference type="InParanoid" id="A0A177C663"/>
    <dbReference type="OrthoDB" id="5384459at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056722">
        <property type="entry name" value="DUF7820"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42078">
        <property type="entry name" value="GLUCAN 1, 4-ALPHA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42078:SF1">
        <property type="entry name" value="GLUCAN 1, 4-ALPHA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25130">
        <property type="entry name" value="DUF7820"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7820" evidence="2">
        <location>
            <begin position="164"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="159"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG03015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="419" mass="46302" checksum="512090DAAABFC3B2" modified="2016-09-07" version="1">MRFPGRSSKTTPTPAVPSILTLFPVLDDTVLEKAPVTHRADNCVGYGLEVVPIERCNTSCGKTVSPDTPEKEVLYATLTDWNRRSKPLPPLPNAAWKVLVKRKWYRLPSNAKNSDHFHADRASQVQLGLLLTICLGLLSVKPRLAKREPSEQSSDVATSPIRPSSPSIPLDTFSLNLSTPRQQSSACLSDSDDADSWPCTSQAKLHISVSSSERPLSQLELTIQKTSGTGTSSYGQQFPPTISAEFDPIYPMNDSDDEVIWHFQASYDRIVLLANDELSFHGQPQHEAERETSGKISPNDSPWVCYFNNTIMEVFVYASQRAGTATNSTQGANNTTETSSLPAFPFVIQIFEQWIQNGTRAYCEQQKVSERGALRKSDAPRYFLSTTDATSVYASSIDKKTKQQAGVSDSACQCQWIVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C6G5</accession>
    <name>A0A177C6G5_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="4">PPIase</shortName>
            <ecNumber evidence="4">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CC84DRAFT_1261428</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cyclophilin-type PPIase family.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="4"/>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG02721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033086.1">
        <property type="nucleotide sequence ID" value="XM_018185064.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C6G5"/>
    <dbReference type="STRING" id="1460663.A0A177C6G5"/>
    <dbReference type="GeneID" id="28768550"/>
    <dbReference type="InParanoid" id="A0A177C6G5"/>
    <dbReference type="OrthoDB" id="193499at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016018">
        <property type="term" value="F:cyclosporin A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000025">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase CYP19-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071:SF561">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="6">
        <location>
            <begin position="64"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="36"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAG02721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="229" mass="24435" checksum="73D65634B3D15489" modified="2016-09-07" version="1">MGCFSSKTKSEETEISRPAQTGSVPPSIPHPGASTKDVSPENQTPKQTGGTEKEPTNPENPVVFFDITIGGRNAGRIQMELYMDVVPATSENFRRFCTGEADGSYKGSIFHRVIPSFMIQGGDFINGDGTGSATIFGSESFDDENFNLKHTRPGLLSMANSGPNTNGCQFFILTEMAPHLDGKHVVFGDVIGGMNVVREIENTQTGAGDRPVKDVVISNCGQVSGAKVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C6P2</accession>
    <name>A0A177C6P2_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">pyruvate, water dikinase</fullName>
            <ecNumber evidence="5">2.7.9.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Pyruvate, water dikinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CC84DRAFT_916692</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>pyruvate + ATP + H2O = phosphoenolpyruvate + AMP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:11364"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.9.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the PEP-utilizing enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.7.9.2" evidence="5"/>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG02791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033156.1">
        <property type="nucleotide sequence ID" value="XM_018187888.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C6P2"/>
    <dbReference type="STRING" id="1460663.A0A177C6P2"/>
    <dbReference type="GeneID" id="28771374"/>
    <dbReference type="InParanoid" id="A0A177C6P2"/>
    <dbReference type="OrthoDB" id="6123450at2759"/>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008986">
        <property type="term" value="F:pyruvate, water dikinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.20:FF:000010">
        <property type="entry name" value="Phosphoenolpyruvate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000017">
        <property type="entry name" value="Phosphoenolpyruvate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.10">
        <property type="entry name" value="Phosphohistidine domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008279">
        <property type="entry name" value="PEP-util_enz_mobile_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006319">
        <property type="entry name" value="PEP_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018274">
        <property type="entry name" value="PEP_util_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000121">
        <property type="entry name" value="PEP_util_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023151">
        <property type="entry name" value="PEP_util_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036637">
        <property type="entry name" value="Phosphohistidine_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002192">
        <property type="entry name" value="PPDK_AMP/ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01418">
        <property type="entry name" value="PEP_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005057">
        <property type="entry name" value="PRK06464.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43030">
        <property type="entry name" value="PHOSPHOENOLPYRUVATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43030:SF1">
        <property type="entry name" value="PHOSPHOENOLPYRUVATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00391">
        <property type="entry name" value="PEP-utilizers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02896">
        <property type="entry name" value="PEP-utilizers_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01326">
        <property type="entry name" value="PPDK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000854">
        <property type="entry name" value="PEP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52009">
        <property type="entry name" value="Phosphohistidine domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00742">
        <property type="entry name" value="PEP_ENZYMES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00370">
        <property type="entry name" value="PEP_ENZYMES_PHOS_SITE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyruvate phosphate dikinase AMP/ATP-binding" evidence="15">
        <location>
            <begin position="31"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="PEP-utilising enzyme mobile" evidence="14">
        <location>
            <begin position="397"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="domain" description="PEP-utilising enzyme C-terminal" evidence="16">
        <location>
            <begin position="489"/>
            <end position="800"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00033470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF01326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="OAG02791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="816" mass="89380" checksum="B94150EB525D1907" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C6R5</accession>
    <name>A0A177C6R5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Sedlin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1098286</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG03225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033590.1">
        <property type="nucleotide sequence ID" value="XM_018174761.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C6R5"/>
    <dbReference type="FunCoup" id="A0A177C6R5">
        <property type="interactions" value="346"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177C6R5"/>
    <dbReference type="GeneID" id="28758247"/>
    <dbReference type="InParanoid" id="A0A177C6R5"/>
    <dbReference type="OrthoDB" id="10252102at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14825">
        <property type="entry name" value="TRAPPC2_sedlin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006722">
        <property type="entry name" value="Sedlin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12403">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04628">
        <property type="entry name" value="Sedlin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG03225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="186" mass="20091" checksum="CB20452FC7EA8664" modified="2016-09-07" version="1">MSYYFTIFSPTDTPLFTHEFGTSRSSGDGLPHFSPTDRHLAPFILHSALDILEEVQWGPSSTAGSAPMYLKHIDKYANNYVSCWITGANVRFLLLTRPRDEVLGSGGGLGGQRGSLAGGRLGVGGGGGVYRPDAPATEEAVKNFFVDVYESWVKTVMNPFFHAGNGDVVKSPVFRARVAAAAKKYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C755</accession>
    <name>A0A177C755_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Acyl-protein thioesterase 1</fullName>
            <ecNumber evidence="2">3.1.2.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Palmitoyl-protein hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CC84DRAFT_1261403</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Hydrolyzes fatty acids from S-acylated cysteine residues in proteins with a strong preference for palmitoylated G-alpha proteins over other acyl substrates. Mediates the deacylation of G-alpha proteins such as GPA1 in vivo, but has weak or no activity toward palmitoylated Ras proteins. Has weak lysophospholipase activity in vitro; however such activity may not exist in vivo.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>S-hexadecanoyl-L-cysteinyl-[protein] + H2O = L-cysteinyl-[protein] + hexadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19233"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:7896"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="3.1.2.22"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. AB hydrolase 2 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.22" evidence="2"/>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG02692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033057.1">
        <property type="nucleotide sequence ID" value="XM_018185060.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C755"/>
    <dbReference type="STRING" id="1460663.A0A177C755"/>
    <dbReference type="GeneID" id="28768546"/>
    <dbReference type="InParanoid" id="A0A177C755"/>
    <dbReference type="OrthoDB" id="2418081at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008474">
        <property type="term" value="F:palmitoyl-(protein) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050565">
        <property type="entry name" value="LYPA1-2/EST-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003140">
        <property type="entry name" value="PLipase/COase/thioEstase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10655:SF17">
        <property type="entry name" value="LYSOPHOSPHOLIPASE-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10655">
        <property type="entry name" value="LYSOPHOSPHOLIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02230">
        <property type="entry name" value="Abhydrolase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0719">Serine esterase</keyword>
    <feature type="domain" description="Phospholipase/carboxylesterase/thioesterase" evidence="10">
        <location>
            <begin position="16"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OAG02692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="246" mass="26723" checksum="741696EE368A5119" modified="2016-09-07" version="1">MPERTPPIVLAPSASPQDPAKSAAFIFVHGLGDDAEGVESIARQFQTAGKLPYMSWVLPNALHNHDVMSTGWYAPTGLSPFPPSRPELEDEEDEEGITSSAQYLVSLIDDLVSQGVPERRIVLGGFSQGHAMALFTGLTSSKYSGRLGGLVGLSGYLPLIERIPKLREAAGLPEKINHDVQVFIARGTKDMLVPRRYLTLCSNGLLDCGVKQEHLTVKEYDGMGHIMGGAELRDLCTWLETVVPQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C7Q7</accession>
    <name>A0A177C7Q7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF1264-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1097540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the OBAP family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG02882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033247.1">
        <property type="nucleotide sequence ID" value="XM_018174718.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C7Q7"/>
    <dbReference type="STRING" id="1460663.A0A177C7Q7"/>
    <dbReference type="GeneID" id="28758204"/>
    <dbReference type="InParanoid" id="A0A177C7Q7"/>
    <dbReference type="OrthoDB" id="1901244at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010686">
        <property type="entry name" value="OBAP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31360:SF0">
        <property type="entry name" value="OIL BODY-ASSOCIATED PROTEIN 1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06884">
        <property type="entry name" value="DUF1264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG02882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="244" mass="27802" checksum="589C093549018368" modified="2016-09-07" version="1">MDSLPVTNKTTGEPESFKNKALETGAAAVQNFEPVQRICAHLNAFHAYADDPHRGPVEANHYCAHLNDEVRQCILYDSPKQPARIIGIEYMINPRLYSTLDETEQKLWHSHVFEVKSGMLIMPKPPVVPDAAWELAENREMEEVVHLYGKVYHLWQTDRGDTLPLGEPKLMTSYTEAQQMPGGFEKVVDERDARFGSDWRRKKEARSHIEEPEIHENADWVWKGKKAENVTGERKTDVGVIGGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C8C1</accession>
    <name>A0A177C8C1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NACHT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1125114</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG03007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033372.1">
        <property type="nucleotide sequence ID" value="XM_018175711.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C8C1"/>
    <dbReference type="STRING" id="1460663.A0A177C8C1"/>
    <dbReference type="GeneID" id="28759197"/>
    <dbReference type="InParanoid" id="A0A177C8C1"/>
    <dbReference type="OrthoDB" id="443402at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF5">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50837">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="NACHT" evidence="2">
        <location>
            <begin position="293"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG03007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="549" mass="62150" checksum="A606C9FF0CA8F4BD" modified="2016-09-07" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C8V5</accession>
    <name>A0A177C8V5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_962698</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG03208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033573.1">
        <property type="nucleotide sequence ID" value="XM_018187976.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C8V5"/>
    <dbReference type="GeneID" id="28771462"/>
    <dbReference type="InParanoid" id="A0A177C8V5"/>
    <dbReference type="OrthoDB" id="3791782at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="56"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG03208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="361" mass="39817" checksum="A0E51DCDBC7B9DD1" modified="2016-09-07" version="1">MLRTHRKVTFICKRQTLTGAARKLSLLSPTAQPSPADVLRIHRSPSQQHPHHRGHSSPPSSLPSAPRRPPRWRSVSRQPHTALETLHYRSLSPHYMEQDPAFPPLLFSILTAGLSPTRAMEVQSDRVSTAADEPCINKQVKLNIKLRISSMRRSRSDSEIYESPPSPPSTSRHSLPPTSTPRRRLEDFSLPPLQISKARPSIAIDLLPNIPPTPEAMLNPPLSPFTLLCPACHTLRPRIAKGQATAVCRACLTAFKSTERTCKSSHRLGSVLTSFPPLVAGESSESEEEDTNAEAGAGSRKLSIVGGITRVFGMLRGGAAKSRREVRVVRRAGGIMEVVRVEAGLRHGRYSRSRRLLETDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C9T6</accession>
    <name>A0A177C9T6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_854266</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG03517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033882.1">
        <property type="nucleotide sequence ID" value="XM_018187632.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C9T6"/>
    <dbReference type="GeneID" id="28771118"/>
    <dbReference type="InParanoid" id="A0A177C9T6"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG03517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="100" mass="11184" checksum="0B791F413F7BE685" modified="2016-09-07" version="1">MYAYSRSVHSSRPSTISVQLGQSVCKPTGIYPVSPRIEGAPSVFLVPGGILMMFFVRVMLGRCCWSRAFVALRPSLRLVWQARSHLYSKTGSCKRVECSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CA15</accession>
    <name>A0A177CA15_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Calcium-transporting ATPase</fullName>
            <ecNumber evidence="15">7.2.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CC84DRAFT_1149247</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Catalyzes the hydrolysis of ATP coupled with the transport of calcium.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>Ca(2+)(in) + ATP + H2O = Ca(2+)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18105"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.2.2.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="15">Membrane</location>
            <topology evidence="15">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14 15">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.10" evidence="15"/>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG03669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034034.1">
        <property type="nucleotide sequence ID" value="XM_018176666.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CA15"/>
    <dbReference type="FunCoup" id="A0A177CA15">
        <property type="interactions" value="421"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CA15"/>
    <dbReference type="GeneID" id="28760152"/>
    <dbReference type="InParanoid" id="A0A177CA15"/>
    <dbReference type="OrthoDB" id="3352408at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005388">
        <property type="term" value="F:P-type calcium transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140613">
        <property type="term" value="F:P-type manganese transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030026">
        <property type="term" value="P:intracellular manganese ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000040">
        <property type="entry name" value="Calcium-transporting ATPase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000028">
        <property type="entry name" value="Calcium-transporting P-type ATPase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006413">
        <property type="entry name" value="P-type_ATPase_IIA_PMR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01522">
        <property type="entry name" value="ATPase-IIA2_Ca"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42861">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 15" id="KW-0106">Calcium</keyword>
    <keyword evidence="3 15" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="11" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="12 15" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 15" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="345"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="371"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="967"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="997"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="17">
        <location>
            <begin position="46"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="169"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="621"/>
            <end position="642"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00038148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU361146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="OAG03669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="1039" mass="111235" checksum="C698847773A63B97" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CAB6</accession>
    <name>A0A177CAB6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1095977</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG03707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034072.1">
        <property type="nucleotide sequence ID" value="XM_018174641.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CAB6"/>
    <dbReference type="STRING" id="1460663.A0A177CAB6"/>
    <dbReference type="GeneID" id="28758127"/>
    <dbReference type="InParanoid" id="A0A177CAB6"/>
    <dbReference type="OrthoDB" id="46529at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG03707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="271" mass="29218" checksum="F3BE5AC06762C5CC" modified="2016-09-07" version="1">MSACVACQKPLEVEFEPEDYDEDVQMGGSSGKAPAAAPDMVPDDVHLNCGCHFHWDCLLEAYQITECPSCGKNIASTSAAGAQQVLVTLNNEGGLQENLDILPLLTEESYLKAYPADRKCRAFLEFCREGDMSAIIGMLQGDNESDSDSDDDMADEAEGEGEDTADVGIDALLRYQDPIGDMQSGLHAAVQAQSREVAWLLLLLASNLPLLEFPPEVFQEAEALGIMRGLTEDKTDIRSMRDANGKTAEDVAREVGGVWAAGWIGNGRLAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CAM5</accession>
    <name>A0A177CAM5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_867674</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG03817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034182.1">
        <property type="nucleotide sequence ID" value="XM_018187722.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CAM5"/>
    <dbReference type="GeneID" id="28771208"/>
    <dbReference type="InParanoid" id="A0A177CAM5"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG03817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="197" mass="21948" checksum="B6254CD97A1D8E15" modified="2016-09-07" version="1">MEGRRTGRLRCRDGSEDAVLKMKNGQSRSAWVPEGFWSGAFQAEAVQYISDMGSPSQAKRPATALLWAPLIARMPSRARAFVRKFRRYVQCNLFACAFHACHHDPARPPHAATQQCAHRHRLPSPPLRRRRRRQRQELGGSVRPLAVSRQEWITSPAGVGRSQAADTDAIQRRANHSTSAGRLCSRTPPSRGTACDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CBE3</accession>
    <name>A0A177CBE3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">dual-specificity kinase</fullName>
            <ecNumber evidence="1">2.7.12.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CC84DRAFT_1095577</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. Lammer subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.12.1" evidence="1"/>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG04088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034453.1">
        <property type="nucleotide sequence ID" value="XM_018174621.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CBE3"/>
    <dbReference type="FunCoup" id="A0A177CBE3">
        <property type="interactions" value="689"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CBE3"/>
    <dbReference type="GeneID" id="28758107"/>
    <dbReference type="InParanoid" id="A0A177CBE3"/>
    <dbReference type="OrthoDB" id="283111at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004712">
        <property type="term" value="F:protein serine/threonine/tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043484">
        <property type="term" value="P:regulation of RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14134">
        <property type="entry name" value="PKc_CLK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000612">
        <property type="entry name" value="Serine/threonine-protein kinase AFC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051175">
        <property type="entry name" value="CLK_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45646">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE DOA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45646:SF11">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE DOA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="287"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="65"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="109"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="81"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="152"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="182"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="218"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="316"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00051680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OAG04088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="670" mass="76665" checksum="8CCE743524F1332C" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CBM1</accession>
    <name>A0A177CBM1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="14">tRNA-splicing endonuclease-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CC84DRAFT_1093152</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA2/NAM7 helicase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG05054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035419.1">
        <property type="nucleotide sequence ID" value="XM_018174501.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A177CBM1">
        <property type="interactions" value="289"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CBM1"/>
    <dbReference type="GeneID" id="28757987"/>
    <dbReference type="InParanoid" id="A0A177CBM1"/>
    <dbReference type="OrthoDB" id="6513042at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016604">
        <property type="term" value="C:nuclear body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001147">
        <property type="term" value="F:transcription termination site sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006369">
        <property type="term" value="P:termination of RNA polymerase II transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18042">
        <property type="entry name" value="DEXXQc_SETX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000326">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001152">
        <property type="entry name" value="tRNA-splicing endonuclease, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045055">
        <property type="entry name" value="DNA2/NAM7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024481">
        <property type="entry name" value="Helicase_Sen1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056474">
        <property type="entry name" value="SEN1_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887:SF495">
        <property type="entry name" value="HELICASE SENATAXIN ISOFORM X1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23576">
        <property type="entry name" value="SEN1_barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12726">
        <property type="entry name" value="SEN1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="14" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase Sen1 N-terminal" evidence="10">
        <location>
            <begin position="90"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase SEN1 beta-barrel" evidence="13">
        <location>
            <begin position="1132"/>
            <end position="1228"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase helicase" evidence="11">
        <location>
            <begin position="1277"/>
            <end position="1561"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase-like C-terminal" evidence="12">
        <location>
            <begin position="1568"/>
            <end position="1762"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="870"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="934"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1829"/>
            <end position="1940"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="1446"/>
            <end position="1473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="877"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="934"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1849"/>
            <end position="1864"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="1880"/>
            <end position="1891"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1892"/>
            <end position="1905"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF12726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF13086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF13087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF23576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OAG05054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="1940" mass="218877" checksum="B4315A6CE631B42F" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CBS0</accession>
    <name>A0A177CBS0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">tRNA pseudouridine synthase D</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CC84DRAFT_1166295</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the pseudouridine synthase TruD family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG04198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034563.1">
        <property type="nucleotide sequence ID" value="XM_018178924.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CBS0"/>
    <dbReference type="FunCoup" id="A0A177CBS0">
        <property type="interactions" value="1149"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CBS0"/>
    <dbReference type="GeneID" id="28762410"/>
    <dbReference type="InParanoid" id="A0A177CBS0"/>
    <dbReference type="OrthoDB" id="447290at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001522">
        <property type="term" value="P:pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02576">
        <property type="entry name" value="PseudoU_synth_ScPUS7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2350.20">
        <property type="entry name" value="TruD, catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001656">
        <property type="entry name" value="PsdUridine_synth_TruD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011760">
        <property type="entry name" value="PsdUridine_synth_TruD_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056963">
        <property type="entry name" value="PUS7L_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042214">
        <property type="entry name" value="TruD_catalytic"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00094">
        <property type="entry name" value="tRNA_TruD_broad"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13326:SF21">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE PUS7L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13326">
        <property type="entry name" value="TRNA PSEUDOURIDINE SYNTHASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23943">
        <property type="entry name" value="PUS7L_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01142">
        <property type="entry name" value="TruD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037016">
        <property type="entry name" value="Pseudouridin_synth_euk_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50984">
        <property type="entry name" value="TRUD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TRUD" evidence="4">
        <location>
            <begin position="436"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="142"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="261"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="281"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAG04198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="806" mass="89795" checksum="3E136800F3C2786E" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CCJ7</accession>
    <name>A0A177CCJ7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADP-dependent mannitol dehydrogenase</fullName>
            <ecNumber evidence="4">1.1.1.138</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CC84DRAFT_1121146</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.138" evidence="4"/>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG04612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034977.1">
        <property type="nucleotide sequence ID" value="XM_018175600.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CCJ7"/>
    <dbReference type="STRING" id="1460663.A0A177CCJ7"/>
    <dbReference type="GeneID" id="28759086"/>
    <dbReference type="InParanoid" id="A0A177CCJ7"/>
    <dbReference type="OrthoDB" id="1888931at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050085">
        <property type="term" value="F:mannitol 2-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050664">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019594">
        <property type="term" value="P:mannitol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05352">
        <property type="entry name" value="MDH-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000090">
        <property type="entry name" value="NADP-dependent mannitol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008">
        <property type="entry name" value="BENZIL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008:SF3">
        <property type="entry name" value="MANNITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00066645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00069279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAG04612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="266" mass="28605" checksum="317A1BDBCFFFBC17" modified="2016-09-07" version="1">MPSAIPEATELKDLLSLKGKVVVVTGASGPTGIGIEAARGCAEFGADLAITYNSRSAGAEKNAEELSQKYGVKVKAYKCQVGDYANVEKLVQDVIKDFGKIDVFIANAGKTADNGILDASVEQWNEVIQTDLTGSYNCARAVGLHFRERKTGSLILTASMSGHIANYPQEQTSYNVAKAGCIHMARSLANEWRDFARVNSISPGYIDTGLSDFVPQDIQKLWHSMIPMGRDAKAKELKGAFLYFASDASSYTTGADLLIDGGYTTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CD01</accession>
    <name>A0A177CD01_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alcohol acetyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1093855</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG04590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034955.1">
        <property type="nucleotide sequence ID" value="XM_018174539.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CD01"/>
    <dbReference type="STRING" id="1460663.A0A177CD01"/>
    <dbReference type="GeneID" id="28758025"/>
    <dbReference type="InParanoid" id="A0A177CD01"/>
    <dbReference type="OrthoDB" id="2150604at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052058">
        <property type="entry name" value="Alcohol_O-acetyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010828">
        <property type="entry name" value="Atf2/Sli1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28037">
        <property type="entry name" value="ALCOHOL O-ACETYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28037:SF1">
        <property type="entry name" value="ALCOHOL O-ACETYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07247">
        <property type="entry name" value="AATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG04590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="472" mass="51779" checksum="098EF0CB7DC7A2CA" modified="2016-09-07" version="1">MLNGRSTGRFELFSTARHHLGYFKNVACAATYTVASAVKHDVLESLIWGALHKVIARHSMLSAIILNEHKQDSEVYFARLPSIDLRTCVEFLERQSKVAVGDRDEELELLLQDQHRINFREDIGSKPFWRLVILHHPEDQSTFTAVWFFHHALGDGGCGPIFHRTLLSALDMSNPTDAVNPIVKIPTTAILPKFEDLHPHPISWAFFLRAILGSILPSIFAPRAPKLWTGPPVIAPTPLPGTRVQLLPISAPTTTNLLKLSRENGTTLQATLECCIATALFSVLPAEAYDKVNASGPISMRSLIRHEGQPVGDDEFILALAEYTHMHDRTSHPLSSEKFPWEEARAVRSTIQTEVSKQGADNVVSLLRYVSDIHKYFTEKVGQERAVSFELSNLGLIKAGTGAGDGWTLGRCVFSQSPHITGPPIVCSAVTGGDGCCVLTFGWLDGVVDDEMARAVVESVEKLIQGLVGGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CDC9</accession>
    <name>A0A177CDC9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1218673</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG05316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035681.1">
        <property type="nucleotide sequence ID" value="XM_018183022.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CDC9"/>
    <dbReference type="GeneID" id="28766508"/>
    <dbReference type="InParanoid" id="A0A177CDC9"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="49"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG05316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="72" mass="7606" checksum="12D8E5EF8267FFD2" modified="2016-09-07" version="1">MKLRGTLREKPDKQWPSPPINAGRDPVNKSAPSPPPAANKNEGQEKQQEPPSGDKGSSGDGAESTQEGAKDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CDG3</accession>
    <name>A0A177CDG3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1091883</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG05356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035721.1">
        <property type="nucleotide sequence ID" value="XM_018174418.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CDG3"/>
    <dbReference type="STRING" id="1460663.A0A177CDG3"/>
    <dbReference type="GeneID" id="28757904"/>
    <dbReference type="InParanoid" id="A0A177CDG3"/>
    <dbReference type="OrthoDB" id="3943268at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG05356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="74" mass="8681" checksum="9C39FCD90DCB8FBB" modified="2016-09-07" version="1">MEALLCVLVAFIFYKYNRFVFTSGLIHFTTILGINIDVGRLRPIKHYLYLLARVVYYVQVLRAEVLLPVSQHDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CDK7</accession>
    <name>A0A177CDK7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1218678</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG05321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035686.1">
        <property type="nucleotide sequence ID" value="XM_018183024.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CDK7"/>
    <dbReference type="GeneID" id="28766510"/>
    <dbReference type="InParanoid" id="A0A177CDK7"/>
    <dbReference type="OrthoDB" id="10396191at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008058039" evidence="1">
        <location>
            <begin position="20"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG05321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="156" mass="17706" checksum="1138B2176E557C4B" modified="2016-09-07" version="1">MYLPSILGSISTLVATALADQNGICLDPFHSRPNWCGHFTNYSNADRMGCLYANKKCENFDWPFPGDERPEQEKGLPVRLIGSWNCGLCFVFEEKDCQAKLTRMLGQNEIPEGYPTEVIPILGYPMINTTDSLSYFCESPGWYLELSQVECDWWAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CDL1</accession>
    <name>A0A177CDL1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CC84DRAFT_1148035</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG04982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035347.1">
        <property type="nucleotide sequence ID" value="XM_018176616.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CDL1"/>
    <dbReference type="STRING" id="1460663.A0A177CDL1"/>
    <dbReference type="GeneID" id="28760102"/>
    <dbReference type="InParanoid" id="A0A177CDL1"/>
    <dbReference type="OrthoDB" id="10250725at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd08217">
        <property type="entry name" value="STKc_Nek2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000697">
        <property type="entry name" value="G2-specific protein kinase nimA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000151">
        <property type="entry name" value="G2-specific protein kinase nimA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050660">
        <property type="entry name" value="NEK_Ser/Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43671">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE NEK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43671:SF13">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE NEK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6" id="KW-0132">Cell division</keyword>
    <keyword evidence="10 18" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0498">Mitosis</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="17">
        <location>
            <begin position="7"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="385"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="451"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="684"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="390"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="418"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="547"/>
            <end position="560"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="OAG04982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="737" mass="82192" checksum="0E8E6D40E76F5C5E" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2023-06-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CEJ7</accession>
    <name>A0A177CEJ7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1165520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG05208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035573.1">
        <property type="nucleotide sequence ID" value="XM_018178734.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CEJ7"/>
    <dbReference type="GeneID" id="28762220"/>
    <dbReference type="InParanoid" id="A0A177CEJ7"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG05208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="90" mass="9894" checksum="26015FF7C39589FE" modified="2016-09-07" version="1">MPRPRANGFGSLSGFAPSSIASSRCPWPILRCCPSPSLAGARRTEGKRAAAGHQVHRSLAHFRALQPLERCPHKLARCDLQHAYQKTNFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CF84</accession>
    <name>A0A177CF84_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Inosine/uridine-preferring nucleoside hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CC84DRAFT_1196366</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IUNH family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG06274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036639.1">
        <property type="nucleotide sequence ID" value="XM_018181454.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CF84"/>
    <dbReference type="FunCoup" id="A0A177CF84">
        <property type="interactions" value="199"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CF84"/>
    <dbReference type="GeneID" id="28764940"/>
    <dbReference type="InParanoid" id="A0A177CF84"/>
    <dbReference type="OrthoDB" id="432381at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070635">
        <property type="term" value="F:nicotinamide riboside hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070636">
        <property type="term" value="F:nicotinic acid riboside hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008477">
        <property type="term" value="F:purine nucleosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045437">
        <property type="term" value="F:uridine nucleosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006216">
        <property type="term" value="P:cytidine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034355">
        <property type="term" value="P:NAD+ biosynthetic process via the salvage pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019358">
        <property type="term" value="P:nicotinate nucleotide salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006152">
        <property type="term" value="P:purine nucleoside catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008655">
        <property type="term" value="P:pyrimidine-containing compound salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006218">
        <property type="term" value="P:uridine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd02651">
        <property type="entry name" value="nuc_hydro_IU_UC_XIUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.245.10">
        <property type="entry name" value="Ribonucleoside hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001910">
        <property type="entry name" value="Inosine/uridine_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023186">
        <property type="entry name" value="IUNH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036452">
        <property type="entry name" value="Ribo_hydro-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12304">
        <property type="entry name" value="INOSINE-URIDINE PREFERRING NUCLEOSIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12304:SF4">
        <property type="entry name" value="URIDINE NUCLEOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01156">
        <property type="entry name" value="IU_nuc_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53590">
        <property type="entry name" value="Nucleoside hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Inosine/uridine-preferring nucleoside hydrolase" evidence="4">
        <location>
            <begin position="8"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAG06274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="380" mass="40818" checksum="4E0DB5E456F965C3" modified="2016-09-07" version="1">MTAPKVPLWLDCDPGHDDAYALLLACHDPRVELLGVSTVHGNAPLDQTTLNARATLEAIGKRDVKVYIGAHKPIKRVAVSAVDIHGESGLDGVTLLPEPVQPPATDADTLEAIYKALIATPPNTAWLVSTGTLTNIGLLFQKYDDLAGHIKGLSIMGGAVGGGFTDAPMGKTKLEGVRFGNWTPYAEFNIYVDPEASHIVFSHPVLRSKTTLIPLDLTHQVLGTKDVQHTLLYGSDAPLDPAAADTSHTPSRVRALFKQIMVYFASTYAEVFSITEGPPLHDPLAVSAAIYPEIFDDKDGERFQVDIVTEGIHSENAEEVGELGRTKVTKLPPGEGGCRIPRGVDLAKFWASIESSLKKADEASPMPPISREELVKLGVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CFF5</accession>
    <name>A0A177CFF5_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">tRNA(m1A58)-methyltransferase subunit TRM6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_1258887</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRM6/GCD10 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG05440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035805.1">
        <property type="nucleotide sequence ID" value="XM_018184863.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CFF5"/>
    <dbReference type="FunCoup" id="A0A177CFF5">
        <property type="interactions" value="937"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CFF5"/>
    <dbReference type="GeneID" id="28768349"/>
    <dbReference type="InParanoid" id="A0A177CFF5"/>
    <dbReference type="OrthoDB" id="10254665at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031515">
        <property type="term" value="C:tRNA (m1A) methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017423">
        <property type="entry name" value="TRM6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12945">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12945:SF0">
        <property type="entry name" value="TRNA (ADENINE(58)-N(1))-METHYLTRANSFERASE NON-CATALYTIC SUBUNIT TRM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04189">
        <property type="entry name" value="Gcd10p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="266"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="509"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="590"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="272"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="291"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="520"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAG05440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="610" mass="66942" checksum="E0C1748F0A8E4502" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CFG7</accession>
    <name>A0A177CFG7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Small ribosomal subunit protein mS33</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_1164086</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mS33 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG05589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035954.1">
        <property type="nucleotide sequence ID" value="XM_018178405.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CFG7"/>
    <dbReference type="FunCoup" id="A0A177CFG7">
        <property type="interactions" value="176"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CFG7"/>
    <dbReference type="GeneID" id="28761891"/>
    <dbReference type="InParanoid" id="A0A177CFG7"/>
    <dbReference type="OrthoDB" id="2257454at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013219">
        <property type="entry name" value="Ribosomal_mS33"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13362">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOMAL PROTEIN S33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13362:SF2">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08293">
        <property type="entry name" value="MRP-S33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="84"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="87"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="98"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAG05589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="109" mass="12520" checksum="2CD81F2946E4096C" modified="2016-09-07" version="1" fragment="single">MAVSPVSRARVLDLMKVQCKVFSTTFNPERIRLGSRILHQRLKGPSVASYYPPRIGTIPHLRKLYPNFSVMDEQEEDWLEHLGVAKSRGKSPPKKKRTAAESKKFSKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CFH0</accession>
    <name>A0A177CFH0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CC84DRAFT_1092513</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the major facilitator superfamily. DHA1 family. Polyamines/proton antiporter (TC 2.A.1.2.16) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG05538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035903.1">
        <property type="nucleotide sequence ID" value="XM_018174458.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CFH0"/>
    <dbReference type="STRING" id="1460663.A0A177CFH0"/>
    <dbReference type="GeneID" id="28757944"/>
    <dbReference type="InParanoid" id="A0A177CFH0"/>
    <dbReference type="OrthoDB" id="3936150at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF186">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="22"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="111"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="149"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="178"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="243"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="281"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="320"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="351"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="384"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="413"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="24"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAG05538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="458" mass="50480" checksum="EED779AB23530667" modified="2016-09-07" version="1">MHTTIQLEPDEMPTNWRASKKWSATLIIVLMTANITFASSIHTAAIMGVSEAFHVSETVATLPVTTFLLGFATGPLLFAPLSEVLGRTLIFRVVLGLFICFNLACALSPNIYALLILRFLCGFFGAPSVTNSGGSLADIWPQSQRSVPFALFTTGSSLGPVVAPIVGGYVAEHLNWRWHYWIVTSVSGAVYIAMVFLLPETYTTVLLRWKREKTGIKPPRMTFKERYATDLTRPWVMLFTEPILFTLGLYSAFIWGILYLDFTAYPVVFQQGRDWSQGKSGLSFIGIGVGMALATASSPWINDLHGAVVRKIGLKPEARLPHLIFLAWLIPTALFWFGWTAPPPTHPIVPIAAGVPFGIGFVTIFLGTNAYLSDCYGRFSASAWAANAVLRSLFSAGFPLFARQMYVRMGTPWASSTLAFIAVGLAPVPLVLWKWGGWLRGRSRFHISTVELEKDEEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CFW7</accession>
    <name>A0A177CFW7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_1245417</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG06216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036581.1">
        <property type="nucleotide sequence ID" value="XM_018184181.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CFW7"/>
    <dbReference type="STRING" id="1460663.A0A177CFW7"/>
    <dbReference type="GeneID" id="28767667"/>
    <dbReference type="InParanoid" id="A0A177CFW7"/>
    <dbReference type="OrthoDB" id="3783825at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF157">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="100"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="136"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="227"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="33"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAG06216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="321" mass="35910" checksum="EF4CE6957F8778EA" modified="2016-09-07" version="1">MSSSELPIAFVHASDIVPATIALSISGIIVVLLRFWVRVSHKMGVRMDDWLILAALVFVVAMAVVSLYGVSRQAVGYPSEELSPQEQLTSLTPEQRLVELTYWLSSVLMLPATGSVKLSTLYLYRRIFPVETMPAFNILSNLSVVVCALWTIAFFFSRVFGCGIHLQCSWASFAEISTCCTDKFLNQDVLMISDLITDVLIWLLPIPVVRVFEHEVWGLNISTHRKLGVVAIFLLAACSLAAAVVRLLIQLAIHKKGFTARTNVNRQCWYTSSSSYKQLTRISDIIDELVLAVHRGCHRPDRMLLADDASVLQVDIHFERL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CH37</accession>
    <name>A0A177CH37_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1259712</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG06541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036906.1">
        <property type="nucleotide sequence ID" value="XM_018184933.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CH37"/>
    <dbReference type="GeneID" id="28768419"/>
    <dbReference type="InParanoid" id="A0A177CH37"/>
    <dbReference type="OrthoDB" id="3786386at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG06541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="184" mass="20871" checksum="1A0643969F679231" modified="2016-09-07" version="1">MKQAALEMWYGENTFRLGGIGFGCGENLAYPYMVPNHNAFAHLQHVQVHVRGDHAGWADLAKYCETTKSMLRLIAFEVEFVRLAHPDAKSKSLQDAFAEVGPLEVHAEKFVLEYYGKSELLSPARALVVADRMDYREMVGVFEKISIASGGKVVKEAVQRFWYDCKTRVDVDEIWQLPPNSIYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CIB4</accession>
    <name>A0A177CIB4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">GTPase-activating protein GYP5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CC84DRAFT_1117018</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the GYP5 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG07001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037366.1">
        <property type="nucleotide sequence ID" value="XM_018175478.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CIB4"/>
    <dbReference type="STRING" id="1460663.A0A177CIB4"/>
    <dbReference type="GeneID" id="28758964"/>
    <dbReference type="InParanoid" id="A0A177CIB4"/>
    <dbReference type="OrthoDB" id="295078at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.750:FF:000003">
        <property type="entry name" value="GTPase activating protein (Evi5)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000044">
        <property type="entry name" value="GTPase-activating protein GYP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.750">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF9">
        <property type="entry name" value="GTPASE ACTIVATING PROTEIN AND CENTROSOME-ASSOCIATED, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23436">
        <property type="entry name" value="RabGap-TBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="3" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="12">
        <location>
            <begin position="365"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="267"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="400"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="739"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="28"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="71"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="108"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="161"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="187"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="218"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="273"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="422"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00061661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00072088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OAG07001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="875" mass="95974" checksum="5665AFFD9FD00999" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CIM3</accession>
    <name>A0A177CIM3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1163012</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG06680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037045.1">
        <property type="nucleotide sequence ID" value="XM_018178152.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CIM3"/>
    <dbReference type="FunCoup" id="A0A177CIM3">
        <property type="interactions" value="38"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CIM3"/>
    <dbReference type="GeneID" id="28761638"/>
    <dbReference type="InParanoid" id="A0A177CIM3"/>
    <dbReference type="OrthoDB" id="58297at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47562">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47562:SF2">
        <property type="entry name" value="CARBOXYMETHYLENEBUTENOLIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
        <property type="entry name" value="DLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dienelactone hydrolase" evidence="1">
        <location>
            <begin position="32"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG06680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="269" mass="29390" checksum="56DF335EF1E4AC9A" modified="2016-09-07" version="1">MLIQETHKDVPTQAGGDMRIFLFHPTIPNYPKAKFPGVVVFSEIYQVTGPVARFARQIASQGYIVAAPSSYHEFTGPEPLAYDGPGTDAGNEWKITKEVSAYDEDATLSIDLLKSLDTCTGRIGATGMCLGGHLAYRCALDTRISAAVCYFATDIHSHSLGKGKNDDSLARAKDIKGELVMIFGKLDNHVPPAGRDLIRKTLHEAGVTFSFYEHAWAQHAFIRDELSKGRYDAALSGVCFEMLKEVFGRTLRSDLGPRSGGDVEVEDVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CIQ2</accession>
    <name>A0A177CIQ2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1089094</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG06852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037217.1">
        <property type="nucleotide sequence ID" value="XM_018174286.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CIQ2"/>
    <dbReference type="GeneID" id="28757772"/>
    <dbReference type="InParanoid" id="A0A177CIQ2"/>
    <dbReference type="OrthoDB" id="60822at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011893">
        <property type="entry name" value="Selenoprotein_Rdx-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02174">
        <property type="entry name" value="CXXU_selWTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36417">
        <property type="entry name" value="SELENOPROTEIN DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G05220)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36417:SF2">
        <property type="entry name" value="SELENOPROTEIN DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G05220)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10262">
        <property type="entry name" value="Rdx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="100"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG06852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="149" mass="16216" checksum="4B915402BE0A4170" modified="2016-09-07" version="1">MSSAQSAPVSLPRVAITYCTQCRWMLRAAYFGQELLSTFGTQIGEIALIPVTGGVFTAELDATSEDGDGDRPVETKTVLLWDRKAEGGFPETKVLKQRVRDRIDPKRDLGHSDVGGKKGRKEGEGKENVKVEKEGEGGVKDGEVCEDCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CIV9</accession>
    <name>A0A177CIV9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase UbiE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1116876</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG06912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037277.1">
        <property type="nucleotide sequence ID" value="XM_018175471.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CIV9"/>
    <dbReference type="STRING" id="1460663.A0A177CIV9"/>
    <dbReference type="GeneID" id="28758957"/>
    <dbReference type="InParanoid" id="A0A177CIV9"/>
    <dbReference type="OrthoDB" id="10017101at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43861">
        <property type="entry name" value="TRANS-ACONITATE 2-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13847">
        <property type="entry name" value="Methyltransf_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase" evidence="1">
        <location>
            <begin position="37"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG06912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="276" mass="30785" checksum="BC94F67F0C5205DF" modified="2016-09-07" version="1">MSSGPYLHGHHASVLRSHSWRTVENSCPHLIPHLHNTSLKILDVGCGPGTISVDLAARIPQGSVLAIDPSQEVIMKARKHAEEKGVTNIRFEVGDIFNWGAVAGIEESGFDIVHAHQVLQHLQDPLSAMKEMKKLTRKGGILAVRDCDYSAMNHYPPNEGMSKWLDLYRSVAKSIKCDPDIGKRLHAIAMQAGFPRSDIDTSVSAWTFSTPDERAWWCGLWAERSTKSDYKARVLESGLGTEEDLEEIARTWREMEGKEDGWFAVINGEVVAYNRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CIX3</accession>
    <name>A0A177CIX3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1143107</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG06922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037287.1">
        <property type="nucleotide sequence ID" value="XM_018176394.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CIX3"/>
    <dbReference type="STRING" id="1460663.A0A177CIX3"/>
    <dbReference type="GeneID" id="28759880"/>
    <dbReference type="InParanoid" id="A0A177CIX3"/>
    <dbReference type="OrthoDB" id="10249920at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047631">
        <property type="term" value="F:ADP-ribose diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006753">
        <property type="term" value="P:nucleoside phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019693">
        <property type="term" value="P:ribose phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18888">
        <property type="entry name" value="NUDIX_ADPRase_Nudt5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000016">
        <property type="entry name" value="ADP-sugar pyrophosphatase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11839:SF26">
        <property type="entry name" value="ADP-RIBOSE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11839">
        <property type="entry name" value="UDP/ADP-SUGAR PYROPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="2">
        <location>
            <begin position="49"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG06922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="201" mass="22531" checksum="F780A60BC38FF2A1" modified="2016-09-07" version="1">MPQAPKITSVDALPADEAKWIEFQKISWSDQTGKSRVWEAASRKTRGKSGVDAVAIATVIRHPKNPPSTIIILQYRPPVDAVCVEFPAGLVDEKETPKEASIRELHEETGYKGEVTSMSPTIFSDPGMSTANMQLATVEVQLKEGDKEPDQALDDGEFIERLVVPLEELYDRLIQYDQEGKRVDARLWHWAEGLHFAKTML</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CJ96</accession>
    <name>A0A177CJ96_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CC84DRAFT_1215926</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG06909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037274.1">
        <property type="nucleotide sequence ID" value="XM_018182755.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CJ96"/>
    <dbReference type="STRING" id="1460663.A0A177CJ96"/>
    <dbReference type="GeneID" id="28766241"/>
    <dbReference type="InParanoid" id="A0A177CJ96"/>
    <dbReference type="OrthoDB" id="4685598at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053181">
        <property type="entry name" value="EcdB-like_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47785:SF6">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47785">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="46"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="95"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="12"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAG06909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="568" mass="63800" checksum="04F775230C17B89D" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CJF1</accession>
    <name>A0A177CJF1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">SNARE domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CC84DRAFT_1088087</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the syntaxin family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG07436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037801.1">
        <property type="nucleotide sequence ID" value="XM_018174236.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CJF1"/>
    <dbReference type="FunCoup" id="A0A177CJF1">
        <property type="interactions" value="620"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CJF1"/>
    <dbReference type="GeneID" id="28757722"/>
    <dbReference type="InParanoid" id="A0A177CJF1"/>
    <dbReference type="OrthoDB" id="364348at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006896">
        <property type="term" value="P:Golgi to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048278">
        <property type="term" value="P:vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15840">
        <property type="entry name" value="SNARE_Qa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000059">
        <property type="entry name" value="Related to syntaxin 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045242">
        <property type="entry name" value="Syntaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006012">
        <property type="entry name" value="Syntaxin/epimorphin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006011">
        <property type="entry name" value="Syntaxin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957:SF38">
        <property type="entry name" value="LD27581P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05739">
        <property type="entry name" value="SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14523">
        <property type="entry name" value="Syntaxin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00503">
        <property type="entry name" value="SynN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00914">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="249"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="5">
        <location>
            <begin position="176"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="131"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="63"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAG07436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="269" mass="30506" checksum="4C6B6E98883F76A3" modified="2016-09-07" version="1">MSFQHSSAMESQPTTWRREDDPQYADDPEFRDFASKLGDDLFALTSDVARLGSETAKLGTSRETPRVRERVRTAVEETSDKFKDIGERLKKLTTWPDVGPSQRFTQSKLSREFKATLDEFQQLQRQAIEKEKASNSAARAALQDASSPTEERGGFEQEQQQEQLRLANQDDVDFQEQMIIERESEIRSIEQSVGELNELFRDVAHMVHEQGAQLDIIEENVEVTHDASRGAHTNLKQASNYQKSARSKACILLLILAIVLVIIILAVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CJM1</accession>
    <name>A0A177CJM1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Aldolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1089451</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG07172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037537.1">
        <property type="nucleotide sequence ID" value="XM_018174309.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CJM1"/>
    <dbReference type="STRING" id="1460663.A0A177CJM1"/>
    <dbReference type="GeneID" id="28757795"/>
    <dbReference type="InParanoid" id="A0A177CJM1"/>
    <dbReference type="OrthoDB" id="197068at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003855">
        <property type="term" value="F:3-dehydroquinate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00502">
        <property type="entry name" value="DHQase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000135">
        <property type="entry name" value="Pentafunctional AROM polypeptide"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10860">
        <property type="entry name" value="Leucine Dehydrogenase, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001381">
        <property type="entry name" value="DHquinase_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050068">
        <property type="entry name" value="MurA_subfamily"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01093">
        <property type="entry name" value="aroD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43783">
        <property type="entry name" value="UDP-N-ACETYLGLUCOSAMINE 1-CARBOXYVINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43783:SF1">
        <property type="entry name" value="UDP-N-ACETYLGLUCOSAMINE 1-CARBOXYVINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01487">
        <property type="entry name" value="DHquinase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG07172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="680" mass="74765" checksum="D4DAD45B8C3652D4" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CJM7</accession>
    <name>A0A177CJM7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">GPI-anchored wall transfer protein</fullName>
            <ecNumber evidence="9">2.3.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CC84DRAFT_1186583</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">A acetyltransferase, which acetylates the inositol ring of phosphatidylinositol during biosynthesis of GPI-anchor.</text>
    </comment>
    <comment type="function">
        <text evidence="1">Probable acetyltransferase, which acetylates the inositol ring of phosphatidylinositol during biosynthesis of GPI-anchor.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 9">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Endoplasmic reticulum membrane</location>
            <topology evidence="2 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 9">Belongs to the PIGW family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.3.-.-" evidence="9"/>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG07725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038090.1">
        <property type="nucleotide sequence ID" value="XM_018180867.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CJM7"/>
    <dbReference type="FunCoup" id="A0A177CJM7">
        <property type="interactions" value="561"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CJM7"/>
    <dbReference type="GeneID" id="28764353"/>
    <dbReference type="InParanoid" id="A0A177CJM7"/>
    <dbReference type="OrthoDB" id="15270at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032216">
        <property type="term" value="F:glucosaminyl-phosphatidylinositol O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072659">
        <property type="term" value="P:protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009447">
        <property type="entry name" value="PIGW/GWT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20661">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS W PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20661:SF0">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS W PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06423">
        <property type="entry name" value="GWT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017321">
        <property type="entry name" value="GWT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 9" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="136"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="236"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="306"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="347"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="391"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="434"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="462"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU280819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAG07725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="493" mass="54523" checksum="BAC3CBE16E81520A" modified="2016-09-07" version="1">MANDYKQLKTQHVSGHVGSSLFDINSVSLSMPLTILLWSVLQSRMRQFTPYTASAFFIDLLLSCGITLVATTVYSSSPWLLNTLLVAPAAMIYFTDSKPAMPRQSSARRPPKKSDDAEQAKLDALPIKPFLTNYRGSMMVITCIAILAVDFRIFPRRFAKVENWGTSLMDMGVGSFVFTNGVVSVRSSLKTKTGELPPLAKRLVASLRHALPLIALGTVRLVSVKGLDYAEHVTEYGVHWNFFFTLGFIPPFVAIFQSIFALVPSYAVLSCALACIYEIALDKTNLGAFILTAQRTDILSKNREGIFSFFGYLAIFLAGQSLGTYTLPRQVPLDKDASIKTRLRQSILGKLVVSSVLWTALFYISISYYGLGLVVSRRLANLPYFLWVCSFNTYQIAICCAIETFVFPNLYTAVARGEEKQRCREATSQILYAVNRNGLAVFLLANLLTGLVNLTMPTLDMGVVNTMAVLVTYITCIAGLAIWLDRADVSIKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CJT5</accession>
    <name>A0A177CJT5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CC84DRAFT_1088160</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG07511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037876.1">
        <property type="nucleotide sequence ID" value="XM_018174241.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CJT5"/>
    <dbReference type="GeneID" id="28757727"/>
    <dbReference type="InParanoid" id="A0A177CJT5"/>
    <dbReference type="OrthoDB" id="6730379at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000064">
        <property type="entry name" value="MFS allantoate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF10">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="73"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="112"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="136"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="168"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="199"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="331"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="363"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="396"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="426"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="40"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAG07511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="511" mass="56121" checksum="49103163A8578CAE" modified="2016-09-07" version="1">MDPSKQTEVAASQATPEVIQVDAEQEALAKRVLRKIDWRLIPLMFITYNLNFMDKTILSSASVFGLREDTGLVGQQYSWVSSIFYFGYFFWEYPTSYLIPRLPVAKYMAVNTFIWGAVVAVTAACTSYGGLITVRFLLGVAEATITPAFMFITSTWYTRDEIPTRTGYWFAGNSIGGLIASFLAFGIGHITDSLAPWQWMYIVLGVLTFVWGIPLLLFLPDSIEKASFLTEEERKFAADRVVISGTGHTANAGYKLDQVIECLIDPKTWLIFSMSLLTQIPNGGTQNFGNIVLKSFGFTSLQSTLLVIPASVISAGTIAGTGWIAGRFRQLNCLLIICVVIPAVVGSSLIYVRPRTSPGVQLFGYFLMSTGPGGIPLLMSLVGANYKGVTKKMTMTALLFIAYCAGNIAGPQFFRTKDAPHYNLAFRAILVCYCLVVGLAIVLRCYLQWMNAKREREEGVKGSAGAGGVVAGGKMADEDDRGAAAAAQIELRAEDYDDVTDWKTFGFRYRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CJZ5</accession>
    <name>A0A177CJZ5_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Trafficking protein particle complex subunit 2-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1089117</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAPP small subunits family. Sedlin subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG07571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037936.1">
        <property type="nucleotide sequence ID" value="XM_018174287.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CJZ5"/>
    <dbReference type="STRING" id="1460663.A0A177CJZ5"/>
    <dbReference type="GeneID" id="28757773"/>
    <dbReference type="InParanoid" id="A0A177CJZ5"/>
    <dbReference type="OrthoDB" id="18320at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14854">
        <property type="entry name" value="TRAPPC2L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006722">
        <property type="entry name" value="Sedlin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044760">
        <property type="entry name" value="TRAPPC2L"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12403">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04628">
        <property type="entry name" value="Sedlin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG07571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="176" mass="19539" checksum="72C31A6EEC780EE7" modified="2016-09-07" version="1">MSSRVPSIACIGVIGRHNNPLHISLFPAEERAPLEYQFLLSSCLDIFEARLPHKTVDQDFGLLQAVDERLAMYGWLTNTGVKFVVVVDMEGRPANPLDAKSSAAVGLRDADLKPAFRALQTAYIMLLRNPFYNPDEHSPITANGEQRYGSTQITSKKFIQEIKRIGDAWAPGVNVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CK84</accession>
    <name>A0A177CK84_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CC84DRAFT_1173497</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG07903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038268.1">
        <property type="nucleotide sequence ID" value="XM_018180040.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CK84"/>
    <dbReference type="GeneID" id="28763526"/>
    <dbReference type="InParanoid" id="A0A177CK84"/>
    <dbReference type="OrthoDB" id="6509908at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17352">
        <property type="entry name" value="MFS_MCT_SLC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF234">
        <property type="entry name" value="MFS-TYPE TRANSPORTER DBAD-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="121"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="147"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="172"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="206"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="239"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="279"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="317"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="348"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="372"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="411"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="437"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="463"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="5">
        <location>
            <begin position="79"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="40"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAG07903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="686" mass="73719" checksum="1DB554B22AB016B5" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CL54</accession>
    <name>A0A177CL54_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acetyl-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_1257159</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038630.1">
        <property type="nucleotide sequence ID" value="XM_018184702.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CL54"/>
    <dbReference type="STRING" id="1460663.A0A177CL54"/>
    <dbReference type="GeneID" id="28768188"/>
    <dbReference type="InParanoid" id="A0A177CL54"/>
    <dbReference type="OrthoDB" id="5354320at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF25">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_3G11560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="3">
        <location>
            <begin position="159"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="122"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAG08265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="497" mass="54917" checksum="4860E9A49D3468A9" modified="2016-09-07" version="1">MESSPSAMLKLLLPKTPFIFKTALAHTLRFSETSSKWDLRTELTIKVLRDMLGPSNRMTPITKLQHLTTKDTGVKGTVWVSKVQLKTPEEDDVRQLLFKAIQDMGDGTEKWTKCDMHNVEGEWTGGRAGVSDTEPEPTGMSERDKYGKLMGEVKSKVTLLYFHGGAMYLLDPATYRHVTGKLARLTGGRVFSVRYRLAPQNAFPAAILDAFMAYLSLLAPPPDAPHEPVPAAEIVFGGDSAGGLLCTSLLQLLLQIHRSHSGTGLPTVRWYGKDVEIPLPAGLALSSPWLDITRSLPSVEGLAKYDYLPPPSHTQGMNYPPDAAWPADPPRADLYCEGEALKHPLVSPVAAKDWSNSPPTFFGLGEEMLRDEDAVLAKRMHQQGAVVRWREFEAMPHCFAMMLDSLPASKTFFEEYAKFCSEVVDGKAASSDGEKLLAKSLKREAVALDNVTQLTDEEIAKHMQEGQGLRKWYVCMARDHIIGIANPVYTRHAEALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CLN9</accession>
    <name>A0A177CLN9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptide N-acetyl-beta-D-glucosaminyl asparaginase amidase A N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1144439</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG07697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038062.1">
        <property type="nucleotide sequence ID" value="XM_018176457.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CLN9"/>
    <dbReference type="GeneID" id="28759943"/>
    <dbReference type="InParanoid" id="A0A177CLN9"/>
    <dbReference type="OrthoDB" id="1612078at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021102">
        <property type="entry name" value="PNGase_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056948">
        <property type="entry name" value="PNGaseA_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31104">
        <property type="entry name" value="PEPTIDE-N4-(N-ACETYL-BETA-GLUCOSAMINYL)ASPARAGINE AMIDASE A PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25156">
        <property type="entry name" value="PNGase_A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12222">
        <property type="entry name" value="PNGaseA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptide N-acetyl-beta-D-glucosaminyl asparaginase amidase A N-terminal" evidence="2">
        <location>
            <begin position="209"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="594"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="594"/>
            <end position="605"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG07697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="782" mass="85763" checksum="54006B1C7EBE44A4" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2023-06-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CM75</accession>
    <name>A0A177CM75_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1161957</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG07909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038274.1">
        <property type="nucleotide sequence ID" value="XM_018177869.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CM75"/>
    <dbReference type="GeneID" id="28761355"/>
    <dbReference type="InParanoid" id="A0A177CM75"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG07909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="71" mass="7846" checksum="E602D28D9D2B7400" modified="2016-09-07" version="1">MQPQDHRPGTALTLNRMSHTPIFKKQYVSLTSNPLPAILIPYVSPMKAPALLTLLYFLALCEGRGDPSKVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CMG9</accession>
    <name>A0A177CMG9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1140344</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG07957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038322.1">
        <property type="nucleotide sequence ID" value="XM_018176283.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CMG9"/>
    <dbReference type="GeneID" id="28759769"/>
    <dbReference type="InParanoid" id="A0A177CMG9"/>
    <dbReference type="OrthoDB" id="3792198at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="281"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="409"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="294"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG07957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="483" mass="53917" checksum="866CEC0F40A7955B" modified="2016-09-07" version="1" fragment="single">MEDEFDWSDGPINSPSLRAVDTHGFSMGFDLPELSFNALPHSSEPRLPHRDYKYPKAYQEFVELPVGDPFNPYINGSSHLKSAVSPFKRAKIGVYTNRRKPSREDYSNFVLYQASQRVYEATFLKNFVAHALHPNRFDACFSAQDPQESVGQYLKSVADNVNKLATKIIWNTHSRTVNFMANDEKETTVFWDFQQFENQPFANFSPGNTFPVLRLMNQSWHRAFSHPSMVRYSAEQYQIGPDASPFEEIDEVTGHTKLFEGESIAHTASHDRVVRAPRMKKPKISPLPGATLRGNPTTPNDDSLQGLLRYGSPSSFRFSEDTEVPITVYSTSQDMLPLEAIPASDACASGAKSVWGGASGGIVGSCPIHENSMPMNDDAEASTVRITRTPAEEPTCPESLVALQGSDALWKGSGQSSSSEDTTSEDSRKRTLWRMVLIQDHKNRLAERWPQSQQRLDAALDFNSCVERAIKNGDLKPLGAGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CMR5</accession>
    <name>A0A177CMR5_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Golgi apparatus membrane protein TVP38</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Golgi apparatus membrane protein tvp38</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CC84DRAFT_1085925</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Golgi membrane protein involved in vesicular trafficking and spindle migration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TVP38/TMEM64 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039168.1">
        <property type="nucleotide sequence ID" value="XM_018174130.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CMR5"/>
    <dbReference type="FunCoup" id="A0A177CMR5">
        <property type="interactions" value="124"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CMR5"/>
    <dbReference type="GeneID" id="28757616"/>
    <dbReference type="InParanoid" id="A0A177CMR5"/>
    <dbReference type="OrthoDB" id="166803at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000022">
        <property type="term" value="P:mitotic spindle elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051076">
        <property type="entry name" value="Golgi_membrane_TVP38/TMEM64"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032816">
        <property type="entry name" value="VTT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47549:SF1">
        <property type="entry name" value="GOLGI APPARATUS MEMBRANE PROTEIN TVP38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47549">
        <property type="entry name" value="GOLGI APPARATUS MEMBRANE PROTEIN TVP38-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09335">
        <property type="entry name" value="VTT_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="123"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="159"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="236"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="275"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="VTT" evidence="12">
        <location>
            <begin position="142"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="12"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="338"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="42"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="361"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF09335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OAG08803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="389" mass="43007" checksum="8B8BBA87B751FE6A" modified="2016-09-07" version="1">MPVEEDYDARALALPLDDDESPERSPSPIWSRRSHSNSFRQNRPHSAGHARPRSRIRTLVDNYNKLNHQFMSRYEKLSPFKKVLFSVGGIVLFVLSILFLVYNEKIFHAFLPAAKKWRDITAGWLILWALIFIVSFPPLIGYSSLLTIAGFVYGFPNGWFVAATATVAGSTASFLASRSLLKNMVHRLVAHDKRFAALALTLKHDGLKLLIMIRLCPLPYSLCNGAIATFPTVSAASYALATAIVSPKLLLHIFIGAQLAIIAENGGKMDAKSKALSYVSIAIGGVAGVTTGWFMYKKTKERAAQLEAEERAGVRRMSIEELENEYADDPAALEAAETLREDDDDISLRTGWGDEYHDDVTDAEDDALEIPDDPFGAGDAEREDDGTKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CN90</accession>
    <name>A0A177CN90_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1162203</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038582.1">
        <property type="nucleotide sequence ID" value="XM_018177939.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CN90"/>
    <dbReference type="GeneID" id="28761425"/>
    <dbReference type="InParanoid" id="A0A177CN90"/>
    <dbReference type="OrthoDB" id="5375886at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG08217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="70" mass="7326" checksum="9201F224BA170D60" modified="2016-09-07" version="1">MSAQNGGRQSPEPEQQTGAQQSDAPATDINNQGGAPSEGTKQANDDQKANLQSNPTHPLAKHAEETTSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CNF1</accession>
    <name>A0A177CNF1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 10">Peroxisomal membrane protein PEX14</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 10">Peroxin-14</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CC84DRAFT_1214854</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the PEX13-PEX14 docking complex, a translocon channel that specifically mediates the import of peroxisomal cargo proteins bound to PEX5 receptor. The PEX13-PEX14 docking complex forms a large import pore which can be opened to a diameter of about 9 nm. Mechanistically, PEX5 receptor along with cargo proteins associates with the PEX14 subunit of the PEX13-PEX14 docking complex in the cytosol, leading to the insertion of the receptor into the organelle membrane with the concomitant translocation of the cargo into the peroxisome matrix.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9 10">Peroxisome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the peroxin-14 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038714.1">
        <property type="nucleotide sequence ID" value="XM_018182680.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CNF1"/>
    <dbReference type="FunCoup" id="A0A177CNF1">
        <property type="interactions" value="61"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CNF1"/>
    <dbReference type="GeneID" id="28766166"/>
    <dbReference type="InParanoid" id="A0A177CNF1"/>
    <dbReference type="OrthoDB" id="5549158at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990429">
        <property type="term" value="C:peroxisomal importomer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005102">
        <property type="term" value="F:signaling receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016560">
        <property type="term" value="P:protein import into peroxisome matrix, docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000489">
        <property type="entry name" value="Putative peroxisomal membrane anchor protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025655">
        <property type="entry name" value="PEX14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006785">
        <property type="entry name" value="Pex14_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23058">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23058:SF0">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04695">
        <property type="entry name" value="Pex14_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="3 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0811">Translocation</keyword>
    <keyword evidence="2 10" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Peroxisome membrane anchor protein Pex14p N-terminal" evidence="12">
        <location>
            <begin position="4"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="43"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="249"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="53"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="83"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="251"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="289"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="310"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="355"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00046271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU367032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF04695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OAG08349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="377" mass="39785" checksum="DDA334B0E6452DD1" modified="2016-09-07" version="1">MVVREDLVESAVSFLQDPSVASAPLEKRIAFLQSKNLTQEEVDASLARAAEGPSHASSPAPQSSTPSNYAYRPPQSAPAYGSYPPPGYWQQPPPPEPPKRDWRDYFIMATVMGGISYGLYFTAKRYIVPLIAPPTPPQLEQDKASIDESFKRAFDLLDQLNTDTSALKASEEARTARLDNALGEMESVLASLKESSKRQGDDNRRIEDDVRGLRDLIPKALDAQKDATDTRLKELSSELKSLKTLVGNRMGAGAARPPATTTPPSYYGSGQPLGSAPTANNISGAATPTPAPVSAPATPAPEQPTASTSVSDSQGTSAGTTPAPAPEKPAAASSPYGRMANGRAAIPAWQMAAAKKNEESKKDTSESGTAVEASASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CNF5</accession>
    <name>A0A177CNF5_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">DASH complex subunit DUO1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Outer kinetochore protein DUO1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">CC84DRAFT_1162382</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Centromere</location>
            <location evidence="3">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DASH complex DUO1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038795.1">
        <property type="nucleotide sequence ID" value="XM_018177977.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CNF5"/>
    <dbReference type="STRING" id="1460663.A0A177CNF5"/>
    <dbReference type="GeneID" id="28761463"/>
    <dbReference type="InParanoid" id="A0A177CNF5"/>
    <dbReference type="OrthoDB" id="5599235at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042729">
        <property type="term" value="C:DASH complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013960">
        <property type="entry name" value="DASH_Duo1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28216">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DUO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28216:SF1">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DUO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08651">
        <property type="entry name" value="DASH_Duo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0132">Cell division</keyword>
    <keyword evidence="16" id="KW-0137">Centromere</keyword>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="10" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="8" id="KW-0493">Microtubule</keyword>
    <keyword evidence="9" id="KW-0498">Mitosis</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="139"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="11"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="46"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="139"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="192"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00044152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00044358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="OAG08430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="237" mass="25653" checksum="BB44761BBD9383B8" modified="2016-09-07" version="1">MDDRKPDRLSLSDSDSDALFDAPAAQKNQPSAHDTADDGAAPGKARPKESWSTQEEREAALRKELESVRNVNKVIEGVVESLQKAKSNMDTVSRTVTNASTLLQTWTRILSQTEHNQRLILNPQWQGATQDLVDLQEEEVHKQQAAERRAAEEQARREAAQRKAEEAQRKAEATAKPTTRGRGRGGVRPRGASTSSTGQYSVSGQTARGGLNRSSSTSGRAGSGIGRGLRGRGRGLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CNG3</accession>
    <name>A0A177CNG3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA helicase</fullName>
            <ecNumber evidence="3">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CC84DRAFT_586411</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="3"/>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039116.1">
        <property type="nucleotide sequence ID" value="XM_018186785.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CNG3"/>
    <dbReference type="FunCoup" id="A0A177CNG3">
        <property type="interactions" value="46"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CNG3"/>
    <dbReference type="GeneID" id="28770271"/>
    <dbReference type="InParanoid" id="A0A177CNG3"/>
    <dbReference type="OrthoDB" id="5857104at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140658">
        <property type="term" value="F:ATP-dependent chromatin remodeler activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000014">
        <property type="entry name" value="SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10799">
        <property type="entry name" value="SNF2/RAD54 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="12">
        <location>
            <begin position="594"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="13">
        <location>
            <begin position="950"/>
            <end position="1117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="184"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="279"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="525"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1098"/>
            <end position="1118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="51"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="77"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="184"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="313"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="339"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="362"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="381"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="533"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="550"/>
            <end position="564"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OAG08751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="1171" mass="131835" checksum="91E91223CBEF1453" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CQ58</accession>
    <name>A0A177CQ58_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">COX assembly mitochondrial protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CC84DRAFT_1257760</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Required for mitochondrial cytochrome c oxidase (COX) assembly and respiration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the CMC family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG09030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039395.1">
        <property type="nucleotide sequence ID" value="XM_018184760.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CQ58"/>
    <dbReference type="FunCoup" id="A0A177CQ58">
        <property type="interactions" value="68"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CQ58"/>
    <dbReference type="GeneID" id="28768246"/>
    <dbReference type="InParanoid" id="A0A177CQ58"/>
    <dbReference type="OrthoDB" id="532630at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013892">
        <property type="entry name" value="Cyt_c_biogenesis_Cmc1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22977">
        <property type="entry name" value="COX ASSEMBLY MITOCHONDRIAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22977:SF1">
        <property type="entry name" value="COX ASSEMBLY MITOCHONDRIAL PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08583">
        <property type="entry name" value="Cmc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAG09030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="81" mass="9287" checksum="49C9F47C5D915B78" modified="2016-09-07" version="1">MHPHLHTEEVQKGCADVVAALDECHARGFMHKVFGGCTDAKYKVNMCLRAQRLEKTRLNREAAKEKREHIKKVWAEIDANS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CQT8</accession>
    <name>A0A177CQT8_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">homocitrate synthase</fullName>
            <ecNumber evidence="5">2.3.3.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CC84DRAFT_1137876</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>acetyl-CoA + 2-oxoglutarate + H2O = (2R)-homocitrate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12929"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:58884"/>
            <dbReference type="EC" id="2.3.3.14"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:12930"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-lysine biosynthesis via AAA pathway; L-alpha-aminoadipate from 2-oxoglutarate: step 1/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the alpha-IPM synthase/homocitrate synthase family. Homocitrate synthase LYS20/LYS21 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.14" evidence="5"/>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG09875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040240.1">
        <property type="nucleotide sequence ID" value="XM_018176170.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CQT8"/>
    <dbReference type="FunCoup" id="A0A177CQT8">
        <property type="interactions" value="657"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CQT8"/>
    <dbReference type="GeneID" id="28759656"/>
    <dbReference type="InParanoid" id="A0A177CQT8"/>
    <dbReference type="OrthoDB" id="2015253at2759"/>
    <dbReference type="UniPathway" id="UPA00033">
        <property type="reaction ID" value="UER00028"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004410">
        <property type="term" value="F:homocitrate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07948">
        <property type="entry name" value="DRE_TIM_HCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.260:FF:000002">
        <property type="entry name" value="Homocitrate synthase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000032">
        <property type="entry name" value="Homocitrate synthase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02222">
        <property type="entry name" value="Homocitr_synth_fung_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050073">
        <property type="entry name" value="2-IPM_HCS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002034">
        <property type="entry name" value="AIPM/Hcit_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048253">
        <property type="entry name" value="DRE_TIM_HCS_fun_bact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011872">
        <property type="entry name" value="Homocitrate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054691">
        <property type="entry name" value="LeuA/HCS_post-cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02146">
        <property type="entry name" value="LysS_fung_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10277:SF48">
        <property type="entry name" value="HOMOCITRATE SYNTHASE, CYTOSOLIC ISOZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10277">
        <property type="entry name" value="HOMOCITRATE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22617">
        <property type="entry name" value="HCS_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00815">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00816">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0464">Manganese</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="15">
        <location>
            <begin position="57"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="459"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="8"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="466"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OAG09875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="478" mass="52202" checksum="D4F0EBF51D2A7395" modified="2016-09-07" version="1">MCPSIEETPTNGAANGHTNGNAAEEFTPIEARPNPVPHHKSSPYQPVGDFLSNISRFKIIESTLREGEQFANAYFDLEAKIKIAKALDEFGVDYIELTSPAASEQSRLDCEAICKLGLKAKILTHVRCNMEDAKIAVQTGVDGLDVVIGTSSFLREHSHGKDMTYIKNAALEVIQYVKSQGKEIRFSSEDSFRSDLVDLLSLYSAVDKVGVNRVGIADTVGCASPRQVYDLVRTLRGVVSCDIETHFHNDSGCAIANAYCALEAGATHIDTSVLGIGERNGITPLGGLMARMIVADRDYVMGKYNIKKLKEIEELVAEMVEVNIPFNNYITGFCAFTHKAGIHAKAILNNPSTYEIISPADFGMSRYVHFASRLTGWNAIKSRADQLGYNMTDAQYKEVTAQIKIMADVKKITLDDTDAIISAYHHNIVNGVKKPLLEGLSAEDQAKIDAAEEKLGGVKEKRQLDAEAAADAPPAKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CRB9</accession>
    <name>A0A177CRB9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">1,3-beta-glucanosyltransferase</fullName>
            <ecNumber evidence="9">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CC84DRAFT_1137665</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Splits internally a 1,3-beta-glucan molecule and transfers the newly generated reducing end (the donor) to the non-reducing end of another 1,3-beta-glucan molecule (the acceptor) forming a 1,3-beta linkage, resulting in the elongation of 1,3-beta-glucan chains in the cell wall.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cell membrane</location>
            <topology evidence="1 9">Lipid-anchor</topology>
            <topology evidence="1 9">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the glycosyl hydrolase 72 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="9"/>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG09761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040126.1">
        <property type="nucleotide sequence ID" value="XM_018176157.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CRB9"/>
    <dbReference type="FunCoup" id="A0A177CRB9">
        <property type="interactions" value="57"/>
    </dbReference>
    <dbReference type="GeneID" id="28759643"/>
    <dbReference type="InParanoid" id="A0A177CRB9"/>
    <dbReference type="OrthoDB" id="421038at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042124">
        <property type="term" value="F:1,3-beta-glucanosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071970">
        <property type="term" value="P:fungal-type cell wall (1-&gt;3)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000032">
        <property type="entry name" value="1,3-beta-glucanosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004886">
        <property type="entry name" value="Glucanosyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31468">
        <property type="entry name" value="1,3-BETA-GLUCANOSYLTRANSFERASE GAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31468:SF4">
        <property type="entry name" value="1,3-BETA-GLUCANOSYLTRANSFERASE GAS3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03198">
        <property type="entry name" value="Glyco_hydro_72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 9" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="8 9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0732">Signal</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007948973" description="1,3-beta-glucanosyltransferase" evidence="9">
        <location>
            <begin position="22"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="421"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="431"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OAG09761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="474" mass="50711" checksum="A39749384EE390F9" modified="2016-09-07" version="1">MRSLLNSLAVLTGLLTSVAVAVHPVEVQGQDLIDTVTKKRFMIVGVDYQPGGQAGYKPQEGSDPLTNKSVCLRDAIMLQKLGANTIRVYNVDPTLNHDDCASIFNSAGIYMIIDVNGPQSGESINRAEPWTSYHKDYLKRIFGVVENFKNYPNTLAFFSANEVMNDMNTGKVNPQYIRAVQRDLKAYIKAHADRTIPVGYSAADVRDILQDTWAYMQCDNNGDGSESDIFGLNSYSWCGGDATFASAGYDTLVDMFQNSSVPVFFSEYGCNEVMPRVFDEVASLYSDKMAALSGGLVYEYSQEESNFGIAVINDNGTVSLRSDYDALQKQFNKLDVTKFTATGSKITPPKCDKKLITNDAFDSNFTIPAVCPGCQTLIKNGIDKPTNGKLVKVTDTKGPNKVYGSAGGEVSGLTLKLLSNDGVNGPSGETSSPAGQSSASSSAEGSGDKTGAASKLAGGWTLLAAGAVAALTVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CRS8</accession>
    <name>A0A177CRS8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Peptide transporter PTR2-A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CC84DRAFT_1172050</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG09477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039842.1">
        <property type="nucleotide sequence ID" value="XM_018179949.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CRS8"/>
    <dbReference type="GeneID" id="28763435"/>
    <dbReference type="InParanoid" id="A0A177CRS8"/>
    <dbReference type="OrthoDB" id="8904098at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071916">
        <property type="term" value="F:dipeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000085">
        <property type="entry name" value="MFS peptide transporter Ptr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000109">
        <property type="entry name" value="POT_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018456">
        <property type="entry name" value="PTR2_symporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11654">
        <property type="entry name" value="OLIGOPEPTIDE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00854">
        <property type="entry name" value="PTR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01022">
        <property type="entry name" value="PTR2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="145"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="178"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="207"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="266"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="289"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="387"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="434"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="463"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="505"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="541"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="573"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="620"/>
            <end position="647"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAG09477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="647" mass="72129" checksum="C8A79383B5BD6D04" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CSH6</accession>
    <name>A0A177CSH6_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Alpha-1,3/1,6-mannosyltransferase ALG2</fullName>
            <ecNumber evidence="12">2.4.1.132</ecNumber>
            <ecNumber evidence="12">2.4.1.257</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">GDP-Man:Man(1)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CC84DRAFT_1138651</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 12">Mannosylates Man(2)GlcNAc(2)-dolichol diphosphate and Man(1)GlcNAc(2)-dolichol diphosphate to form Man(3)GlcNAc(2)-dolichol diphosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 12">
            <text>a beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + GDP-alpha-D-mannose = an alpha-D-Man-(1-&gt;3)-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:29515"/>
            <dbReference type="Rhea" id="RHEA-COMP:19511"/>
            <dbReference type="Rhea" id="RHEA-COMP:19513"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:58472"/>
            <dbReference type="ChEBI" id="CHEBI:132510"/>
            <dbReference type="EC" id="2.4.1.132"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10 12">
            <dbReference type="Rhea" id="RHEA:29516"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 12">
            <text>an alpha-D-Man-(1-&gt;3)-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + GDP-alpha-D-mannose = an alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:29519"/>
            <dbReference type="Rhea" id="RHEA-COMP:19513"/>
            <dbReference type="Rhea" id="RHEA-COMP:19515"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:132510"/>
            <dbReference type="ChEBI" id="CHEBI:132511"/>
            <dbReference type="EC" id="2.4.1.257"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11 12">
            <dbReference type="Rhea" id="RHEA:29520"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 12">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 12">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the glycosyltransferase group 1 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.132" evidence="12"/>
    <dbReference type="EC" id="2.4.1.257" evidence="12"/>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040621.1">
        <property type="nucleotide sequence ID" value="XM_018176203.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CSH6"/>
    <dbReference type="FunCoup" id="A0A177CSH6">
        <property type="interactions" value="727"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CSH6"/>
    <dbReference type="GeneID" id="28759689"/>
    <dbReference type="InParanoid" id="A0A177CSH6"/>
    <dbReference type="OrthoDB" id="448893at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004378">
        <property type="term" value="F:GDP-Man:Man(1)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102704">
        <property type="term" value="F:GDP-Man:Man(2)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03805">
        <property type="entry name" value="GT4_ALG2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027054">
        <property type="entry name" value="ALG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45918">
        <property type="entry name" value="ALPHA-1,3/1,6-MANNOSYLTRANSFERASE ALG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45918:SF1">
        <property type="entry name" value="ALPHA-1,3_1,6-MANNOSYLTRANSFERASE ALG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 12 15" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="428"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyltransferase subfamily 4-like N-terminal" evidence="14">
        <location>
            <begin position="13"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase family 1" evidence="13">
        <location>
            <begin position="210"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00045103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00045104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU367136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OAG10256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="459" mass="50356" checksum="B9105467F615D73F" modified="2016-09-07" version="1">MQHIVFFHPDLGIGGAERLVVDAAVGLQERGHKVTIYTSHCDPAHCFDEARDGTLDVRVRGNSLVPPTVLGRFAVLCAILRQLHLILHVVVFSNELQLLKPTAFFVDQLSAGIPLLRLLQPAVRVVFYCHFPDKLLAQQGGLLKTLYRRPFDWLESWSTGCSDTIVVNSNFTRGVFAAAFPGLDYRNPGVVYPCVDTRRTNVDEIVPLWANKKVLLSINRFEKKKDVALAIRAFARLAPHERKGARLVIAGGYDPRVADNVATYTALCELADSLKLSHATAKTVITAQRVPDDIAVLFLHSVPTAFKTTLLATSRLLVYTPLHEHFGIVPLEAMLAGTPVLAANEGGPTETVVDGETGWLRDVTKVDDWTEVMRTALADGQGEQTLRNMGKRGKKRVETLFSKEKMAEVLETEIAAMAKNARPPLTPFAAVLFAVAIMGLLAASAMWLALKQAQEAAKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CTU7</accession>
    <name>A0A177CTU7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FAD/NAD(P)-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1081866</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040986.1">
        <property type="nucleotide sequence ID" value="XM_018173952.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CTU7"/>
    <dbReference type="STRING" id="1460663.A0A177CTU7"/>
    <dbReference type="GeneID" id="28757438"/>
    <dbReference type="InParanoid" id="A0A177CTU7"/>
    <dbReference type="OrthoDB" id="2019015at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.405.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050464">
        <property type="entry name" value="Zeta_carotene_desat/Oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42923:SF20">
        <property type="entry name" value="FLAVIN-CONTAINING AMINE OXIDASEDEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42923">
        <property type="entry name" value="PROTOPORPHYRINOGEN OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="262"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="269"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG10621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="580" mass="66780" checksum="F76D4B02ACB32686" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CU49</accession>
    <name>A0A177CU49_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">NADH-ubiquinone oxidoreductase 78 kDa subunit, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CC84DRAFT_1140009</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the complex I 75 kDa subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG11043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041408.1">
        <property type="nucleotide sequence ID" value="XM_018176269.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CU49"/>
    <dbReference type="STRING" id="1460663.A0A177CU49"/>
    <dbReference type="GeneID" id="28759755"/>
    <dbReference type="InParanoid" id="A0A177CU49"/>
    <dbReference type="OrthoDB" id="10249365at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02773">
        <property type="entry name" value="MopB_Res-Cmplx1_Nad11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.740:FF:000001">
        <property type="entry name" value="NADH-quinone oxidoreductase subunit G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.210:FF:000002">
        <property type="entry name" value="NADH-ubiquinone oxidoreductase 75 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.20:FF:000002">
        <property type="entry name" value="NADH-ubiquinone oxidoreductase 75 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.740:FF:000033">
        <property type="entry name" value="NUAM protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006656">
        <property type="entry name" value="Mopterin_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006963">
        <property type="entry name" value="Mopterin_OxRdtase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000283">
        <property type="entry name" value="NADH_UbQ_OxRdtase_75kDa_su_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054351">
        <property type="entry name" value="NADH_UbQ_OxRdtase_ferredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010228">
        <property type="entry name" value="NADH_UbQ_OxRdtase_Gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019574">
        <property type="entry name" value="NADH_UbQ_OxRdtase_Gsu_4Fe4S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015405">
        <property type="entry name" value="NDUFS1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050123">
        <property type="entry name" value="Prok_molybdopt-oxidoreductase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01973">
        <property type="entry name" value="NuoG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43105:SF13">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 75 KDA SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43105">
        <property type="entry name" value="RESPIRATORY NITRATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13510">
        <property type="entry name" value="Fer2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22151">
        <property type="entry name" value="Fer4_NDSU1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22117">
        <property type="entry name" value="Fer4_Nqo3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00384">
        <property type="entry name" value="Molybdopterin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10588">
        <property type="entry name" value="NADH-G_4Fe-4S_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09326">
        <property type="entry name" value="NADH_dhqG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00929">
        <property type="entry name" value="NADH-G_4Fe-4S_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="2Fe-2S ferredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54862">
        <property type="entry name" value="4Fe-4S ferredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53706">
        <property type="entry name" value="Formate dehydrogenase/DMSO reductase, domains 1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51839">
        <property type="entry name" value="4FE4S_HC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51669">
        <property type="entry name" value="4FE4S_MOW_BIS_MGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00641">
        <property type="entry name" value="COMPLEX1_75K_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00642">
        <property type="entry name" value="COMPLEX1_75K_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00643">
        <property type="entry name" value="COMPLEX1_75K_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-1278">Translocase</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="13">
        <location>
            <begin position="33"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S His(Cys)3-ligated-type" evidence="15">
        <location>
            <begin position="111"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S Mo/W bis-MGD-type" evidence="14">
        <location>
            <begin position="250"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="730"/>
            <end position="749"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00070722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OAG11043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="749" mass="81896" checksum="5B20AB1B60EE5931" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CU87</accession>
    <name>A0A177CU87_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Mif2/CENP-C cupin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_518792</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CENP-C/MIF2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG11083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041448.1">
        <property type="nucleotide sequence ID" value="XM_018186592.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CU87"/>
    <dbReference type="STRING" id="1460663.A0A177CU87"/>
    <dbReference type="GeneID" id="28770078"/>
    <dbReference type="InParanoid" id="A0A177CU87"/>
    <dbReference type="OrthoDB" id="1939643at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019237">
        <property type="term" value="F:centromeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051315">
        <property type="term" value="P:attachment of mitotic spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051382">
        <property type="term" value="P:kinetochore assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051455">
        <property type="term" value="P:spindle attachment to meiosis I kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028386">
        <property type="entry name" value="CENP-C/Mif2/cnp3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025974">
        <property type="entry name" value="Mif2/CENP-C_cupin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028929">
        <property type="entry name" value="Mif2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16684">
        <property type="entry name" value="CENTROMERE PROTEIN C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16684:SF11">
        <property type="entry name" value="CENTROMERE PROTEIN C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11699">
        <property type="entry name" value="CENP-C_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15624">
        <property type="entry name" value="Mif2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mif2 N-terminal" evidence="7">
        <location>
            <begin position="14"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="Mif2/CENP-C cupin" evidence="6">
        <location>
            <begin position="598"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="26"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="248"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="499"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="28"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="81"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="104"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="126"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="279"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="351"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="385"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="502"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF11699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF15624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAG11083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="747" mass="81692" checksum="9E4E68E536491665" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CUA8</accession>
    <name>A0A177CUA8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Ras-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CC84DRAFT_1113030</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040963.1">
        <property type="nucleotide sequence ID" value="XM_018175339.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CUA8"/>
    <dbReference type="STRING" id="1460663.A0A177CUA8"/>
    <dbReference type="GeneID" id="28758825"/>
    <dbReference type="InParanoid" id="A0A177CUA8"/>
    <dbReference type="OrthoDB" id="63533at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031901">
        <property type="term" value="C:early endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034058">
        <property type="term" value="P:endosomal vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01860">
        <property type="entry name" value="Rab5_related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000464">
        <property type="entry name" value="GTP-binding protein ypt5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47978">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0636">Prenylation</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="187"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="199"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OAG10598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="220" mass="24021" checksum="8F4792A09C587478" modified="2016-09-07" version="1">MSARPQQGGRPGGSRFAQFKLVLLGESAVGKSSLVLRFVKDQFDDYRESTIGAAFLTQTIALDESTTVKFEIWDTAGQERYKSLAPMYYRNANCAVVVYDITQASSLDKAKAWVKELQRQANENIIIALAGNKLDLVTESPDKRAIPAADAEQYAREAGLLFFETSAKTSENVRELFTAIAKKLPLDQGGPRNLRPGQGRQSVNLGRDAAQTQGPAGCNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CUG3</accession>
    <name>A0A177CUG3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SUR7-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1161372</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040792.1">
        <property type="nucleotide sequence ID" value="XM_018177717.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CUG3"/>
    <dbReference type="FunCoup" id="A0A177CUG3">
        <property type="interactions" value="68"/>
    </dbReference>
    <dbReference type="GeneID" id="28761203"/>
    <dbReference type="InParanoid" id="A0A177CUG3"/>
    <dbReference type="OrthoDB" id="5419460at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045121">
        <property type="term" value="C:membrane raft"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030866">
        <property type="term" value="P:cortical actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032185">
        <property type="term" value="P:septin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009571">
        <property type="entry name" value="SUR7/Rim9-like_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36414">
        <property type="entry name" value="PROTEIN SUR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36414:SF1">
        <property type="entry name" value="PROTEIN SUR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06687">
        <property type="entry name" value="SUR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="114"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="143"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="188"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="220"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG10427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="249" mass="27317" checksum="33EB844198C4979F" modified="2016-09-07" version="1">MVARPILGAAALILLAGGLLLQWFLILSGGVNSSPENQFYFLQASTNGIAGARNPSRWTFWAICGVDGSGHNANCGSPVPALPFDPPRNFGTQNNIPGSFIGTHKYYYLSRFMFAWYLIAFFFAHIALFTGLLALFSRLGGYLSALTTFVAMFFQALGAALMTAWVVQGRNAWRSNGFDAHVGTKLMAFAWTSFVCYFLASLLFCIGGTIGRESSGSSRMSRKRSTRSTRSRGSFLDTESQRRVKDNYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CV53</accession>
    <name>A0A177CV53_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PLP-dependent transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1224478</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG11403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041768.1">
        <property type="nucleotide sequence ID" value="XM_018183540.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CV53"/>
    <dbReference type="STRING" id="1460663.A0A177CV53"/>
    <dbReference type="GeneID" id="28767026"/>
    <dbReference type="InParanoid" id="A0A177CV53"/>
    <dbReference type="OrthoDB" id="7042322at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050478">
        <property type="entry name" value="Ethylene_sulfur-biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43795:SF39">
        <property type="entry name" value="AMINOTRANSFERASE CLASS I_CLASSII DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43795">
        <property type="entry name" value="BIFUNCTIONAL ASPARTATE AMINOTRANSFERASE AND GLUTAMATE/ASPARTATE-PREPHENATE AMINOTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00753">
        <property type="entry name" value="ACCSYNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="2">
        <location>
            <begin position="8"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG11403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="260" mass="28689" checksum="599CD4E6E5EE6E3A" modified="2016-09-07" version="1">MSGEQIKITGTATALHEAFGSSIADPGQGIMTSRPYYGRFELDFGLKAGLKMVAADTPLGTCLQPDVVDAFEQTSQKAKAGSIEIRAVLIINPQNRLRRCCPEDTLIAFMCFHQKHHIHLSSDDIYAFSGFDPTERGTHPFTSVLWFEPQIDESLLHVTYGMVKNYAVPGLRIGALITHSKPLLKAVKSVTRFRNPSGPSVAIASATLYDRTWMRSFITLSRERVGEAYTYFSERLSPMGVTYLSRVNAGFLCLSISQSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CXA5</accession>
    <name>A0A177CXA5_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glycoside hydrolase family 92 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_1107365</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG11678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042043.1">
        <property type="nucleotide sequence ID" value="XM_018175173.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CXA5"/>
    <dbReference type="STRING" id="1460663.A0A177CXA5"/>
    <dbReference type="GeneID" id="28758659"/>
    <dbReference type="InParanoid" id="A0A177CXA5"/>
    <dbReference type="OrthoDB" id="449263at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000224">
        <property type="term" value="F:peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006516">
        <property type="term" value="P:glycoprotein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.98.10:FF:000028">
        <property type="entry name" value="Alpha-1,2-mannosidase family protein (AFU_orthologue AFUA_5G10520)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.60:FF:000002">
        <property type="entry name" value="Glycosyl hydrolase family 92"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2080.10:FF:000012">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.60">
        <property type="entry name" value="alpha-1,2-mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1610.10">
        <property type="entry name" value="alpha-1,2-mannosidases domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2080.10">
        <property type="entry name" value="GH92 mannosidase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005887">
        <property type="entry name" value="GH92_a_mannosidase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041371">
        <property type="entry name" value="GH92_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012939">
        <property type="entry name" value="Glyco_hydro_92"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050883">
        <property type="entry name" value="PNGase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01180">
        <property type="entry name" value="aman2_put"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12143:SF27">
        <property type="entry name" value="ALPHA-1,2-MANNOSIDASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_5G10520)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12143">
        <property type="entry name" value="PEPTIDE N-GLYCANASE PNGASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07971">
        <property type="entry name" value="Glyco_hydro_92"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17678">
        <property type="entry name" value="Glyco_hydro_92N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008058704" description="Glycoside hydrolase family 92 protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 92 N-terminal" evidence="3">
        <location>
            <begin position="27"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 92" evidence="2">
        <location>
            <begin position="309"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="823"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAG11678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="823" mass="91151" checksum="E0D21DFA5DB574A2" modified="2016-09-07" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CXJ5</accession>
    <name>A0A177CXJ5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1079400</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG11921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042286.1">
        <property type="nucleotide sequence ID" value="XM_018173846.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CXJ5"/>
    <dbReference type="STRING" id="1460663.A0A177CXJ5"/>
    <dbReference type="GeneID" id="28757332"/>
    <dbReference type="InParanoid" id="A0A177CXJ5"/>
    <dbReference type="OrthoDB" id="422736at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22997">
        <property type="entry name" value="GT_LH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36587">
        <property type="entry name" value="EXPRESSION SITE-ASSOCIATED GENE 3 (ESAG3)-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36587:SF2">
        <property type="entry name" value="EXPRESSION SITE-ASSOCIATED GENE 3 (ESAG3)-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="37"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="602"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="602"/>
            <end position="684"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG11921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="730" mass="82737" checksum="AF6A79B316586769" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2023-06-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CXX6</accession>
    <name>A0A177CXX6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_122988</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042789.1">
        <property type="nucleotide sequence ID" value="XM_018183682.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CXX6"/>
    <dbReference type="GeneID" id="28767168"/>
    <dbReference type="InParanoid" id="A0A177CXX6"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG12424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="151" mass="17188" checksum="2E6BA7781256D570" modified="2016-09-07" version="1">MFVNTILVGFEALVPFVPLGPVPWLTDMPNDGWVSVFPISTQKVPLLGLPEPIKEADLGYKYVYVADDLSYGTACGSLNQGLKLINRMLIRHTIGRFRRTYHRDSSPWVLLRRSKICKHLMSLKSCQSLSLTIFLLHAYLFDIRIMFGVCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2023-06-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CYU0</accession>
    <name>A0A177CYU0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_157531</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018043089.1">
        <property type="nucleotide sequence ID" value="XM_018185406.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CYU0"/>
    <dbReference type="GeneID" id="28768892"/>
    <dbReference type="InParanoid" id="A0A177CYU0"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG12724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="127" mass="14179" checksum="1C0FB5353006F469" modified="2016-09-07" version="1">MASPNMVAHAHVRSGFAASSPTAGAICRSGISGGFMWKRKVWWTLCLSGTVGARSHGTNRPWYVSGWFGQRMHAQTRLLARRGGCSQRMHVGCTGISQRLYSQYTMTARKATWELDPRLTGLARWHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CYZ1</accession>
    <name>A0A177CYZ1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1068612</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042726.1">
        <property type="nucleotide sequence ID" value="XM_018173648.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CYZ1"/>
    <dbReference type="GeneID" id="28757134"/>
    <dbReference type="InParanoid" id="A0A177CYZ1"/>
    <dbReference type="OrthoDB" id="3794293at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843:SF2">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="5"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG12361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="157" mass="18518" checksum="1A21A05C2000F372" modified="2016-09-07" version="1" fragment="single">EQKFATVIVGLTMHMFLVHETLLTHYSKFFRAALQRGFAETEPKTVTLKVVEAPLFEIFVHWLYHRRLRSAACNDDKELVAHYENSRNRTSIVDVLVKLYVFGDVYQLTSFRKVTLRTLFHHFHSSKFFPLYSTFNLEFAKLSTKDPLCRLIVDWPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CZU5</accession>
    <name>A0A177CZU5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cupin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1135099</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042807.1">
        <property type="nucleotide sequence ID" value="XM_018176044.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CZU5"/>
    <dbReference type="STRING" id="1460663.A0A177CZU5"/>
    <dbReference type="GeneID" id="28759530"/>
    <dbReference type="InParanoid" id="A0A177CZU5"/>
    <dbReference type="OrthoDB" id="2588190at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02215">
        <property type="entry name" value="cupin_QDO_N_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053146">
        <property type="entry name" value="QDO-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36440">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_8G07350)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36440:SF1">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_8G07350)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin type-2" evidence="1">
        <location>
            <begin position="62"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG12442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="352" mass="38511" checksum="5A31B1F1590EE02C" modified="2016-09-07" version="1">MSPLPLSTIPPQTHTSYLLDQLAGERLSIPGSKGVFRILASSAQTSGAIAVFTSGAVLADAPGFHWHEEAHDVFLVTKGYLKLWNGDKCRVMGPGDFAYVPPKVIHNPLLLGPHTETYGLVAPGDWIDFFRHVGESYAGVLVPENDDRDLKSLLIPKLMAAKDRFDVHFQRDPSYQPPEEAPWEESENQLAEPGSPYFLRGNTGPRWVLGGVMSRPFIHAEQTGGKFAISSIESSELYGGSVLGRWMAFKSVDHCFCVLEGLLKVRLGGSESWNEVREGQTLIVAAGETFTIEFGSRYVRAWSFTNGEGIEEVIRKGGESYAGYVIPEAPLNVDEGRLAKAFEELGVSIGQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177D0V0</accession>
    <name>A0A177D0V0_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">VOC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1212530</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG13071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018043436.1">
        <property type="nucleotide sequence ID" value="XM_018182461.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177D0V0"/>
    <dbReference type="GeneID" id="28765947"/>
    <dbReference type="InParanoid" id="A0A177D0V0"/>
    <dbReference type="OrthoDB" id="16820at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="entry name" value="2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG13071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="102" mass="10945" checksum="00D194162912F7F0" modified="2016-09-07" version="1">MRRPNTFSHFGIVVPDVEKAESRIGDAGGRIVNRVGKEVDISDDALANAYGLRVEAIGELDEGELEAVVEAFNGDRKTGAIQSAFAEDPDGNLVEVQPMCVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177D0Z2</accession>
    <name>A0A177D0Z2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative endo-exoxylanase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CC84DRAFT_1077797</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 30 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018043044.1">
        <property type="nucleotide sequence ID" value="XM_018173773.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177D0Z2"/>
    <dbReference type="STRING" id="1460663.A0A177D0Z2"/>
    <dbReference type="GeneID" id="28757259"/>
    <dbReference type="InParanoid" id="A0A177D0Z2"/>
    <dbReference type="OrthoDB" id="2012278at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004348">
        <property type="term" value="F:glucosylceramidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006680">
        <property type="term" value="P:glucosylceramide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033452">
        <property type="entry name" value="GH30_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049161">
        <property type="entry name" value="GH59_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001139">
        <property type="entry name" value="Glyco_hydro_30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11069">
        <property type="entry name" value="GLUCOSYLCERAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11069:SF23">
        <property type="entry name" value="LYSOSOMAL ACID GLUCOSYLCERAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17189">
        <property type="entry name" value="Glyco_hydro_30C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02057">
        <property type="entry name" value="Glyco_hydro_59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0858">Xylan degradation</keyword>
    <feature type="domain" description="Glycosyl hydrolase family 59 catalytic" evidence="5">
        <location>
            <begin position="44"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 30 beta sandwich" evidence="6">
        <location>
            <begin position="363"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF17189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAG12679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="457" mass="48463" checksum="6521C38CBA1FBEED" modified="2016-09-07" version="1">MHALKVQAATTITVDLSKTYQTMDGFGVSETFQRANQMHALSPQLQRTALDLLFNRTSGAGFSILRNGIGSSPDSSSDHMVSIQPKNPGGPSAAPKYVWDANDNSQVWLSTEAVSNYGLRTVYANAWSAPGYMKTNNNDANGGSLCGVSGASCASGDWKKAYAEYLVQYLTYYREIGVKITHLGFLNEPDLTTSYASMRSNGQQAADVVKVLRPALDRANFTDVKIACCDAEGWSSQQGMMSGLKGVEDMLGTITGHAYTSAPTSPINTKHPVWQTENADLQGAWTTGFGTGSGSTAGLGLLWAERISDAITKANVSAYLYWVGVQGGATNSKLIRISDDKTQIIASKRLWAFANWSRHVRPGAVRVGTSGVPSGARVSAFRNEDGRVAVQVVQSGSGAGSVNVKVMGFVAKSVKAWLTDDSHNCDEQAATVVSDGSVSANVPGKSMVTIVLEGDAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177D218</accession>
    <name>A0A177D218_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_179758</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG13089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018043454.1">
        <property type="nucleotide sequence ID" value="XM_018185475.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177D218"/>
    <dbReference type="GeneID" id="28768961"/>
    <dbReference type="InParanoid" id="A0A177D218"/>
    <dbReference type="OrthoDB" id="10523855at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="177"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="309"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="755"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="29"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="180"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="192"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="230"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="240"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="318"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG13089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="804" mass="90316" checksum="DE825E9DBAA20EF7" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BU15</accession>
    <name>A0A177BU15_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ribosomal protein 60S</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CC84DRAFT_1169645</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">P1 and P2 exist as dimers at the large ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein P1/P2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441563">
        <property type="protein sequence ID" value="OAF98902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029268.1">
        <property type="nucleotide sequence ID" value="XM_018179712.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BU15"/>
    <dbReference type="FunCoup" id="A0A177BU15">
        <property type="interactions" value="912"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177BU15"/>
    <dbReference type="GeneID" id="28763198"/>
    <dbReference type="InParanoid" id="A0A177BU15"/>
    <dbReference type="OrthoDB" id="1227494at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002182">
        <property type="term" value="P:cytoplasmic translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05833">
        <property type="entry name" value="Ribosomal_P2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.1410:FF:000002">
        <property type="entry name" value="60S acidic ribosomal protein P2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01478">
        <property type="entry name" value="Ribosomal_L12_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038716">
        <property type="entry name" value="P1/P2_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027534">
        <property type="entry name" value="Ribosomal_P1/P2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001859">
        <property type="entry name" value="Ribosomal_P1/P2_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044076">
        <property type="entry name" value="Ribosomal_P2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21141">
        <property type="entry name" value="60S ACIDIC RIBOSOMAL PROTEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21141:SF5">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN P2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00428">
        <property type="entry name" value="Ribosomal_60s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00456">
        <property type="entry name" value="RIBOSOMALP2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="62"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="94"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAF98902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="111" mass="10934" checksum="EF895E26E972176F" modified="2016-09-07" version="1">MKHLAAYLLLGLGGNTSPSASDIKDVLSSVGIEADSERLDKLLSELEGKDINELIASGSEKLASVPSGGSGAAAAGGAAAGGAAPAEEAAAAPAEEEKEESDDDMGFGLFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BU41</accession>
    <name>A0A177BU41_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">MADS-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CC84DRAFT_1131632</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the MEF2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441563">
        <property type="protein sequence ID" value="OAF98932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029298.1">
        <property type="nucleotide sequence ID" value="XM_018175910.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BU41"/>
    <dbReference type="STRING" id="1460663.A0A177BU41"/>
    <dbReference type="GeneID" id="28759396"/>
    <dbReference type="InParanoid" id="A0A177BU41"/>
    <dbReference type="OrthoDB" id="1898716at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008301">
        <property type="term" value="F:DNA binding, bending"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033554">
        <property type="term" value="P:cellular response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00265">
        <property type="entry name" value="MADS_MEF2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1810.10:FF:000013">
        <property type="entry name" value="Transcription factor, MADS-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1810.10">
        <property type="entry name" value="Transcription factor, MADS-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050142">
        <property type="entry name" value="MADS-box/MEF2_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033896">
        <property type="entry name" value="MEF2-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002100">
        <property type="entry name" value="TF_MADSbox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036879">
        <property type="entry name" value="TF_MADSbox_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48019">
        <property type="entry name" value="SERUM RESPONSE FACTOR HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00319">
        <property type="entry name" value="SRF-TF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00404">
        <property type="entry name" value="MADSDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00432">
        <property type="entry name" value="MADS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55455">
        <property type="entry name" value="SRF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00350">
        <property type="entry name" value="MADS_BOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50066">
        <property type="entry name" value="MADS_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="MADS-box" evidence="8">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="77"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="523"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="77"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="212"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="245"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="322"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="364"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="421"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="471"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAF98932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="573" mass="62663" checksum="6CBBEF514BC6633A" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BUV9</accession>
    <name>A0A177BUV9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cytoplasmic tRNA 2-thiolation protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">NCS2</name>
        <name evidence="3" type="synonym">CTU2</name>
        <name evidence="4" type="ORF">CC84DRAFT_1105571</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with NCS6 that ligates sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. May also be involved in protein urmylation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CTU2/NCS2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441564">
        <property type="protein sequence ID" value="OAF98760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029126.1">
        <property type="nucleotide sequence ID" value="XM_018175103.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BUV9"/>
    <dbReference type="FunCoup" id="A0A177BUV9">
        <property type="interactions" value="172"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177BUV9"/>
    <dbReference type="GeneID" id="28758589"/>
    <dbReference type="InParanoid" id="A0A177BUV9"/>
    <dbReference type="OrthoDB" id="25129at2759"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016783">
        <property type="term" value="F:sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032447">
        <property type="term" value="P:protein urmylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002143">
        <property type="term" value="P:tRNA wobble position uridine thiolation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03054">
        <property type="entry name" value="CTU2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019407">
        <property type="entry name" value="CTU2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20882">
        <property type="entry name" value="CYTOPLASMIC TRNA 2-THIOLATION PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20882:SF14">
        <property type="entry name" value="CYTOPLASMIC TRNA 2-THIOLATION PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10288">
        <property type="entry name" value="CTU2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0819">tRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAF98760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="382" mass="41543" checksum="7CF33004F410361C" modified="2016-09-07" version="1">MPGKRIAQVAEQLCRRCTENQAVLVVRRDALCRDCFVRYVHTKVIKHMESFRVRHADPNRQRKLLLALSLGASSVTLLHILDHLLETQTSKSGRTGFGLSVLFVETAGDASHQVRLSKVRQAYPDYDIASLPLHDVFRLVPDQESLSGLLPGLATVQELSPADKLAKLFGSLTSATARADVAATLRTRLVVEYARSSGCEVVLWGDSTTKLAEKTLAETAKGRGFSLPWHVADGETPFGLAFNYPLRDLLKKELVAYVEIVGSPLPSLVLDSAPTQASMSSKNTTIDDLMKQYFESVEENFPSIVSNVVRTTGKLTATSNTNDASVCDLCSMPVSDGRFGIHGWGGDQHGIADPVRASSGRRLCYGCTRSIPSTTNPSNVVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BVK2</accession>
    <name>A0A177BVK2_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">Protein phosphatase methylesterase 1</fullName>
            <shortName evidence="7">PME-1</shortName>
            <ecNumber evidence="7">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CC84DRAFT_1169720</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Demethylates proteins that have been reversibly carboxymethylated. Demethylates the phosphatase PP2A catalytic subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>[phosphatase 2A protein]-C-terminal L-leucine methyl ester + H2O = [phosphatase 2A protein]-C-terminal L-leucine + methanol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48548"/>
            <dbReference type="Rhea" id="RHEA-COMP:12134"/>
            <dbReference type="Rhea" id="RHEA-COMP:12135"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17790"/>
            <dbReference type="ChEBI" id="CHEBI:90516"/>
            <dbReference type="ChEBI" id="CHEBI:90517"/>
            <dbReference type="EC" id="3.1.1.89"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the AB hydrolase superfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="7"/>
    <dbReference type="EMBL" id="KV441563">
        <property type="protein sequence ID" value="OAF99000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029366.1">
        <property type="nucleotide sequence ID" value="XM_018179736.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BVK2"/>
    <dbReference type="FunCoup" id="A0A177BVK2">
        <property type="interactions" value="838"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177BVK2"/>
    <dbReference type="GeneID" id="28763222"/>
    <dbReference type="InParanoid" id="A0A177BVK2"/>
    <dbReference type="OrthoDB" id="194865at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051723">
        <property type="term" value="F:protein methylesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016812">
        <property type="entry name" value="PPase_methylesterase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14189:SF0">
        <property type="entry name" value="PROTEIN PHOSPHATASE METHYLESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14189">
        <property type="entry name" value="PROTEIN PHOSPHATASE METHYLESTERASE-1 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF022950">
        <property type="entry name" value="PPase_methylesterase_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0719">Serine esterase</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="10">
        <location>
            <begin position="98"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="15"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="22"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="184"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="210"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR022950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR022950-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OAF99000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="378" mass="41002" checksum="63E148EB8DC13AE4" modified="2016-09-07" version="1">MSDLAKAFAKTKLSALPSPEPLAEDPADAYEDDSSSASSMSSTGTVIPTSNQRPAPVLHWSSYFSQEFYLERPASPMSRHAKFHVYLTPPASPKANLLVLHHGAGSSALSFALMAKEVRKLMPDVGILAVEAREHGSVVWDAEGHVDADLSVDVLGRDLVDMIQLTASKMGWTELPTMVLIGHSLGGAVVTHVANKGVLGSKVLGFAVLDVVEGSAMEALKHMQSYLASRPKTFPSLPAAIEWHIRSRTLRNPQSARASVPSLLLQTPDGKWAWRTELGSTEAYWENWFNGMSAKFLGGKGAKLLILAGTDRLDKELMIGQMQGKFQLQVFPAAGHFLQEDLPEKTAEAIVEFVKRNDRSTLVLPPKVSDLLAQGKKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BVL3</accession>
    <name>A0A177BVL3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">non-reducing end alpha-L-arabinofuranosidase</fullName>
            <ecNumber evidence="4">3.2.1.55</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CC84DRAFT_1232783</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing alpha-L-arabinofuranoside residues in alpha-L-arabinosides.</text>
            <dbReference type="EC" id="3.2.1.55"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Glycan metabolism; L-arabinan degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 51 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.55" evidence="4"/>
    <dbReference type="EMBL" id="KV441562">
        <property type="protein sequence ID" value="OAF99354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029720.1">
        <property type="nucleotide sequence ID" value="XM_018183772.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BVL3"/>
    <dbReference type="STRING" id="1460663.A0A177BVL3"/>
    <dbReference type="GeneID" id="28767258"/>
    <dbReference type="InParanoid" id="A0A177BVL3"/>
    <dbReference type="OrthoDB" id="406864at2759"/>
    <dbReference type="UniPathway" id="UPA00667"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046556">
        <property type="term" value="F:alpha-L-arabinofuranosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031222">
        <property type="term" value="P:arabinan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046373">
        <property type="term" value="P:L-arabinose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010720">
        <property type="entry name" value="Alpha-L-AF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055235">
        <property type="entry name" value="ASD1_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051563">
        <property type="entry name" value="Glycosyl_Hydrolase_51"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31776">
        <property type="entry name" value="ALPHA-L-ARABINOFURANOSIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31776:SF0">
        <property type="entry name" value="ALPHA-L-ARABINOFURANOSIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06964">
        <property type="entry name" value="Alpha-L-AF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22848">
        <property type="entry name" value="ASD1_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00813">
        <property type="entry name" value="Alpha-L-AF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008057371" description="non-reducing end alpha-L-arabinofuranosidase" evidence="8">
        <location>
            <begin position="20"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-L-arabinofuranosidase C-terminal" evidence="9">
        <location>
            <begin position="487"/>
            <end position="667"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAF99354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="686" mass="75006" checksum="0CB4AC3B53F62818" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BWI4</accession>
    <name>A0A177BWI4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Sec63-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CC84DRAFT_1264651</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441563">
        <property type="protein sequence ID" value="OAF99111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029477.1">
        <property type="nucleotide sequence ID" value="XM_018185327.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A177BWI4">
        <property type="interactions" value="1266"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177BWI4"/>
    <dbReference type="GeneID" id="28768813"/>
    <dbReference type="InParanoid" id="A0A177BWI4"/>
    <dbReference type="OrthoDB" id="5575at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000393">
        <property type="term" value="P:spliceosomal conformational changes to generate catalytic conformation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18019">
        <property type="entry name" value="DEXHc_Brr2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18021">
        <property type="entry name" value="DEXHc_Brr2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18795">
        <property type="entry name" value="SF2_C_Ski2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3380.10:FF:000005">
        <property type="entry name" value="Pre-mRNA splicing helicase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000133">
        <property type="entry name" value="Pre-mRNA splicing helicase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000004">
        <property type="entry name" value="RNA helicase, activating signal cointegrator 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000102">
        <property type="entry name" value="RNA helicase, activating signal cointegrator 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000368">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein 200 kDa helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000012">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000024">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000004">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3380.10:FF:000001">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000062">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000254">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3380.10">
        <property type="entry name" value="Sec63 N-terminal domain-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041094">
        <property type="entry name" value="Brr2_helicase_PWI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048863">
        <property type="entry name" value="BRR2_plug"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050474">
        <property type="entry name" value="Hel308_SKI2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004179">
        <property type="entry name" value="Sec63-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057842">
        <property type="entry name" value="WH_MER3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47961:SF4">
        <property type="entry name" value="ACTIVATING SIGNAL COINTEGRATOR 1 COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47961">
        <property type="entry name" value="DNA POLYMERASE THETA, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05260)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21188">
        <property type="entry name" value="BRR2_plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18149">
        <property type="entry name" value="Helicase_PWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02889">
        <property type="entry name" value="Sec63"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23445">
        <property type="entry name" value="WHD_SNRNP200"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039073">
        <property type="entry name" value="BRR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00973">
        <property type="entry name" value="Sec63"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158702">
        <property type="entry name" value="Sec63 N-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="553"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="8">
        <location>
            <begin position="776"/>
            <end position="984"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="1404"/>
            <end position="1580"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="36"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="238"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="55"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="256"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAF99111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="2222" mass="250088" checksum="C945AD65BD14974E" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BWW6</accession>
    <name>A0A177BWW6_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphatidylinositol 3-kinase VPS34</fullName>
            <ecNumber evidence="7">2.7.1.137</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CC84DRAFT_1104805</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12709"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
            <dbReference type="ChEBI" id="CHEBI:58088"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.137"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:12710"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.137" evidence="7"/>
    <dbReference type="EMBL" id="KV441562">
        <property type="protein sequence ID" value="OAF99450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029816.1">
        <property type="nucleotide sequence ID" value="XM_018175071.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BWW6"/>
    <dbReference type="FunCoup" id="A0A177BWW6">
        <property type="interactions" value="815"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177BWW6"/>
    <dbReference type="GeneID" id="28758557"/>
    <dbReference type="InParanoid" id="A0A177BWW6"/>
    <dbReference type="OrthoDB" id="67688at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071561">
        <property type="term" value="C:nucleus-vacuole junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034271">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex, class III, type I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034272">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex, class III, type II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016303">
        <property type="term" value="F:1-phosphatidylinositol-3-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032120">
        <property type="term" value="P:ascospore-type prospore membrane formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051365">
        <property type="term" value="P:cellular response to potassium ion starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000425">
        <property type="term" value="P:pexophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd08397">
        <property type="entry name" value="C2_PI3K_class_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00870">
        <property type="entry name" value="PI3Ka_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00896">
        <property type="entry name" value="PI3Kc_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1070.11:FF:000002">
        <property type="entry name" value="Phosphatidylinositol 3-kinase catalytic subunit type 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1010.10:FF:000002">
        <property type="entry name" value="Phosphatidylinositol 3-kinase catalytic subunit type 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.70:FF:000009">
        <property type="entry name" value="Phosphatidylinositol 3-kinase VPS34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1010.10">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.70">
        <property type="entry name" value="Phosphatidylinositol 3-kinase, accessory domain (PIK)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057756">
        <property type="entry name" value="PI3-kinase_type3/VPS34_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015433">
        <property type="entry name" value="PI3/4_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002420">
        <property type="entry name" value="PI3K-type_C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001263">
        <property type="entry name" value="PI3K_accessory_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042236">
        <property type="entry name" value="PI3K_accessory_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008290">
        <property type="entry name" value="PI3K_Vps34"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048:SF7">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00792">
        <property type="entry name" value="PI3K_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00613">
        <property type="entry name" value="PI3Ka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000587">
        <property type="entry name" value="PI3K_Vps34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00142">
        <property type="entry name" value="PI3K_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00145">
        <property type="entry name" value="PI3Ka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51547">
        <property type="entry name" value="C2_PI3K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00915">
        <property type="entry name" value="PI3_4_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00916">
        <property type="entry name" value="PI3_4_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51545">
        <property type="entry name" value="PIK_HELICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="C2 PI3K-type" evidence="11">
        <location>
            <begin position="26"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="PIK helical" evidence="10">
        <location>
            <begin position="349"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="9">
        <location>
            <begin position="609"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="230"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="329"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="329"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OAF99450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="892" mass="101194" checksum="B624437F9159F070" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BXA8</accession>
    <name>A0A177BXA8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_350235</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441560">
        <property type="protein sequence ID" value="OAF99944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030310.1">
        <property type="nucleotide sequence ID" value="XM_018185870.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BXA8"/>
    <dbReference type="GeneID" id="28769356"/>
    <dbReference type="InParanoid" id="A0A177BXA8"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAF99944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="169" mass="18395" checksum="62E6BE3693B41D84" modified="2016-09-07" version="1">MCVAPDLEVACLNILSLIARGCALSHQPQPAPAPSVYRTHSCSSPLSTRSNCPSRRPDAPSTHARSAERGKWTRTRIALLSDVTTVSWIHCVGTACEVEPVVTSVCSAVCPRSSPTFLLVLVHLERTRRQYSFVTCASRGRTLGTHLSKLVYVGHASTPRLMRGSRPME</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2023-06-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BXH5</accession>
    <name>A0A177BXH5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1232577</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441562">
        <property type="protein sequence ID" value="OAF99217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029583.1">
        <property type="nucleotide sequence ID" value="XM_018183767.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BXH5"/>
    <dbReference type="GeneID" id="28767253"/>
    <dbReference type="InParanoid" id="A0A177BXH5"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAF99217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="189" mass="20881" checksum="77543C80F99084DC" modified="2016-09-07" version="1">MHPTMAALRIDSSEILPEEVTELAATSNHRVDVLEQSKRNIDSMPAEAISEAASPLEVFVKGNKSSEQFEKGLADTALNGSIDGNDRINELKNEIHPLLGRDRWSDSGFSKITADKWEQLEPSVTLNQGSNITTAKIRKDSSTESSYLDMTSSVSATDDVVDRILDKITEMIKSKFKHLEHGHPAKFSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BXU9</accession>
    <name>A0A177BXU9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_360705</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441560">
        <property type="protein sequence ID" value="OAG00145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030510.1">
        <property type="nucleotide sequence ID" value="XM_018185904.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BXU9"/>
    <dbReference type="GeneID" id="28769390"/>
    <dbReference type="InParanoid" id="A0A177BXU9"/>
    <dbReference type="OrthoDB" id="62952at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG00145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="352" mass="38976" checksum="668E1FA0E83E06ED" modified="2016-09-07" version="1">MALPKSGLLSLPAEIRNTIYDQTFNGDMSNADMLALMNTSKQLHLEAGSRFYANNPFIVRVPAPSVPGATVLPPVNDRYLPFLKDLGVEISAGCATRPRVQEIAAAITRLTTIGAEFDRVSFLIQFPPELSFFLQDRYDDPILDKSHPITTALHNLLDSGVSKVVHIWMNGAWFAPGLATSMKARYCSGLKFMLINEEHKIIELGDPFVYERAPTGLCSCTPIKIFGMIEDSGDDLNTVVGLDLDMGEHTLELHRTDHEPFLGVDEDINTKAEEDLTDEDDIDMEDLIAFDPADVDAIEENWNQTFSLLDHEEMMTKEIEFLVVMAPHMLLPSSEAAGIVTAPQPAIAMTRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BXW4</accession>
    <name>A0A177BXW4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1130158</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441560">
        <property type="protein sequence ID" value="OAG00193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030558.1">
        <property type="nucleotide sequence ID" value="XM_018175850.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BXW4"/>
    <dbReference type="STRING" id="1460663.A0A177BXW4"/>
    <dbReference type="GeneID" id="28759336"/>
    <dbReference type="InParanoid" id="A0A177BXW4"/>
    <dbReference type="OrthoDB" id="6359943at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47369">
        <property type="entry name" value="BTB/POZ DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47369:SF1">
        <property type="entry name" value="BTB_POZ DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="193"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="503"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="712"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="727"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="795"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="837"/>
            <end position="847"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG00193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="957" mass="105233" checksum="EF78FDC410A3AEE2" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BYG4</accession>
    <name>A0A177BYG4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cupredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CC84DRAFT_1051067</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441562">
        <property type="protein sequence ID" value="OAF99456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029822.1">
        <property type="nucleotide sequence ID" value="XM_018173479.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BYG4"/>
    <dbReference type="STRING" id="1460663.A0A177BYG4"/>
    <dbReference type="GeneID" id="28756965"/>
    <dbReference type="InParanoid" id="A0A177BYG4"/>
    <dbReference type="OrthoDB" id="2331100at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00920">
        <property type="entry name" value="Cupredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000923">
        <property type="entry name" value="BlueCu_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052953">
        <property type="entry name" value="Ser-rich/MCO-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34883:SF17">
        <property type="entry name" value="CUPREDOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34883">
        <property type="entry name" value="SERINE-RICH PROTEIN, PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00127">
        <property type="entry name" value="Copper-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0186">Copper</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008057488" evidence="3">
        <location>
            <begin position="20"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="Blue (type 1) copper" evidence="4">
        <location>
            <begin position="23"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAF99456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="134" mass="14041" checksum="40AE82FCB4ABEC12" modified="2016-09-07" version="1" fragment="single">MRFSIFTAATAALAGSAAAVDHLVVVGNGTLTFEPANVTAAEGDTVTFKFWPKSHSVAQAAFASPCTPMANGFWSGFIPSEKGAAMETFMINITNASQPLWYYCSRGNHCQEGMVGVINAPKSGQKTLAAFAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2023-06-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BZ10</accession>
    <name>A0A177BZ10_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_382435</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441561">
        <property type="protein sequence ID" value="OAF99767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030133.1">
        <property type="nucleotide sequence ID" value="XM_018185982.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BZ10"/>
    <dbReference type="GeneID" id="28769468"/>
    <dbReference type="InParanoid" id="A0A177BZ10"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAF99767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="111" mass="12236" checksum="779C5F59534B8309" modified="2016-09-07" version="1">MQFSEAVHTLPPRYIQPPFAGSQREHSSLPRCAAGVPADLHSLPSLAGHQLETIPAEKGRRATKAHHCFNDPAGFGHASQCITSLRRSSDCRMRCTTPKQENMEQEDGIDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BZ82</accession>
    <name>A0A177BZ82_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Actin cytoskeleton-regulatory complex protein PAN1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Actin cytoskeleton-regulatory complex protein pan1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">CC84DRAFT_1102159</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23 24">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Component of the PAN1 actin cytoskeleton-regulatory complex required for the internalization of endosomes during actin-coupled endocytosis. The complex links the site of endocytosis to the cell membrane-associated actin cytoskeleton. Mediates uptake of external molecules and vacuolar degradation of plasma membrane proteins. Plays a role in the proper organization of the cell membrane-associated actin cytoskeleton and promotes its destabilization.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the PAN1 actin cytoskeleton-regulatory complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Actin patch</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the PAN1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441559">
        <property type="protein sequence ID" value="OAG00291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030656.1">
        <property type="nucleotide sequence ID" value="XM_018174950.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A177BZ82">
        <property type="interactions" value="62"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177BZ82"/>
    <dbReference type="GeneID" id="28758436"/>
    <dbReference type="InParanoid" id="A0A177BZ82"/>
    <dbReference type="OrthoDB" id="2015333at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00052">
        <property type="entry name" value="EH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000349">
        <property type="entry name" value="Actin cytoskeleton-regulatory complex protein PAN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013182">
        <property type="entry name" value="DUF1720"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000261">
        <property type="entry name" value="EH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003124">
        <property type="entry name" value="WH2_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11216:SF173">
        <property type="entry name" value="ACTIN CYTOSKELETON-REGULATORY COMPLEX PROTEIN PAN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11216">
        <property type="entry name" value="EH DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08226">
        <property type="entry name" value="DUF1720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12763">
        <property type="entry name" value="EH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02205">
        <property type="entry name" value="WH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00027">
        <property type="entry name" value="EH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00246">
        <property type="entry name" value="WH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50031">
        <property type="entry name" value="EH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51082">
        <property type="entry name" value="WH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13 18" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="16" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="12" id="KW-0967">Endosome</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EH" evidence="20">
        <location>
            <begin position="159"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="EH" evidence="20">
        <location>
            <begin position="428"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="21">
        <location>
            <begin position="461"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="domain" description="WH2" evidence="22">
        <location>
            <begin position="1379"/>
            <end position="1396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="257"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="557"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="729"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="785"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="857"/>
            <end position="1411"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="18">
        <location>
            <begin position="680"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="17"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="52"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="281"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="315"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="567"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="596"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="785"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="865"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="905"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="929"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="957"/>
            <end position="989"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="1014"/>
            <end position="1036"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="1043"/>
            <end position="1061"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="1068"/>
            <end position="1104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="1111"/>
            <end position="1122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="19">
        <location>
            <begin position="1130"/>
            <end position="1141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="1143"/>
            <end position="1156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="19">
        <location>
            <begin position="1167"/>
            <end position="1182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="1183"/>
            <end position="1205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="1221"/>
            <end position="1230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="1237"/>
            <end position="1246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="19">
        <location>
            <begin position="1274"/>
            <end position="1293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="19">
        <location>
            <begin position="1335"/>
            <end position="1373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00015110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00020728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00025194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="OAG00291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="1411" mass="153371" checksum="F890AB6FEA7B206B" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BZD5</accession>
    <name>A0A177BZD5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1221450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441558">
        <property type="protein sequence ID" value="OAG00894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031259.1">
        <property type="nucleotide sequence ID" value="XM_018183275.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BZD5"/>
    <dbReference type="GeneID" id="28766761"/>
    <dbReference type="InParanoid" id="A0A177BZD5"/>
    <dbReference type="OrthoDB" id="3783929at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG00894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="138" mass="15776" checksum="9C56E05F37F1F124" modified="2016-09-07" version="1">MAPILRNNQDRDSSNYQHHCGLCNRAPGNRCFKQSHVAYCEACGDIFTVRSSKCGGGCLSHPYSRGYNLRYKKLKSKLPADDRNDHDLNLEAEAREQMKAEAEKKQQVAAANEAAKEKELTNKEKKKLRFIQKGKRYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BZR6</accession>
    <name>A0A177BZR6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter ATP-binding protein uup-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CC84DRAFT_1155874</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441560">
        <property type="protein sequence ID" value="OAF99936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030302.1">
        <property type="nucleotide sequence ID" value="XM_018176953.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BZR6"/>
    <dbReference type="STRING" id="1460663.A0A177BZR6"/>
    <dbReference type="GeneID" id="28760439"/>
    <dbReference type="InParanoid" id="A0A177BZR6"/>
    <dbReference type="OrthoDB" id="2110130at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03221">
        <property type="entry name" value="ABCF_EF-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050611">
        <property type="entry name" value="ABCF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211">
        <property type="entry name" value="ATP-BINDING TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211:SF135">
        <property type="entry name" value="ATPASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G16440)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="43"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="475"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="683"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="688"/>
            <end position="701"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAF99936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="739" mass="81560" checksum="245CE615395F00CF" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C217</accession>
    <name>A0A177C217_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1168111</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441558">
        <property type="protein sequence ID" value="OAG00892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031257.1">
        <property type="nucleotide sequence ID" value="XM_018179321.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C217"/>
    <dbReference type="GeneID" id="28762807"/>
    <dbReference type="InParanoid" id="A0A177C217"/>
    <dbReference type="OrthoDB" id="5086500at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046536">
        <property type="entry name" value="DUF6601"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20246">
        <property type="entry name" value="DUF6601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG00892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="152" mass="17354" checksum="55A37DF37010BA7B" modified="2016-09-07" version="1">MRKSIDDKQITPVSPAPTYVVSFPQSCTISSDQSSRKIPPFDQSQQLCEELEYAHGVDEPACLRSLTKIHRLPDAPRTPLDSRSIITYCLQDLDTPALNKLNRRLWNCGANPYVKTLSHQLTFERRIVVTEDPSLHLCSYAFWEHMLDPTPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C301</accession>
    <name>A0A177C301_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Beta-xylanase</fullName>
            <ecNumber evidence="7">3.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CC84DRAFT_1100976</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>Endohydrolysis of (1-&gt;4)-beta-D-xylosidic linkages in xylans.</text>
            <dbReference type="EC" id="3.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the glycosyl hydrolase 10 (cellulase F) family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.8" evidence="7"/>
    <dbReference type="EMBL" id="KV441558">
        <property type="protein sequence ID" value="OAG01158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031523.1">
        <property type="nucleotide sequence ID" value="XM_018174891.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C301"/>
    <dbReference type="STRING" id="1460663.A0A177C301"/>
    <dbReference type="GeneID" id="28758377"/>
    <dbReference type="InParanoid" id="A0A177C301"/>
    <dbReference type="OrthoDB" id="3055998at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030248">
        <property type="term" value="F:cellulose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031176">
        <property type="term" value="F:endo-1,4-beta-xylanase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000254">
        <property type="entry name" value="CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035971">
        <property type="entry name" value="CBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044846">
        <property type="entry name" value="GH10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001000">
        <property type="entry name" value="GH10_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31490:SF76">
        <property type="entry name" value="ENDO-1,4-BETA-XYLANASE C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31490">
        <property type="entry name" value="GLYCOSYL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00734">
        <property type="entry name" value="CBM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00331">
        <property type="entry name" value="Glyco_hydro_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00134">
        <property type="entry name" value="GLHYDRLASE10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00236">
        <property type="entry name" value="fCBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00633">
        <property type="entry name" value="Glyco_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57180">
        <property type="entry name" value="Cellulose-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00562">
        <property type="entry name" value="CBM1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51164">
        <property type="entry name" value="CBM1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51760">
        <property type="entry name" value="GH10_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5 7 11" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 7 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 7" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0732">Signal</keyword>
    <keyword evidence="11" id="KW-0858">Xylan degradation</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008057677" description="Beta-xylanase" evidence="8">
        <location>
            <begin position="20"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="domain" description="CBM1" evidence="9">
        <location>
            <begin position="19"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="GH10" evidence="10">
        <location>
            <begin position="136"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OAG01158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="417" mass="43418" checksum="876AA87D96B953FD" modified="2016-09-07" version="1">MHSLYFTVLTLSSTSAVLAAVPVYGQCGGNGFTGDKACASGTQCKEMNPWYSQCLPGAGSAAPAPSSAAPVASSAVAAAPTTLLTRSAIVVKPSTASSVAAATPTKGNVAGSGANGAKCSINEAFKAKGKKYIGVAADQGTLSNAQNAQVIKDNFGQVTPENSMKWDATEATQGKFTFSGSDALVKFATDNAKLVRGHTTVWHSQLPTWVSSITDKATLEKVMISHIQGVIGKYKGKVYAWDVVNEIFSEDGSFRSSVFYNVLGEGFVATAFKTARAADSAAKLYINDYNLDSPTYAKTKAMAANVKKWVAAGVPIDGIGSQSHLSGVWPISDYPAALKLLCGSASECAMTELDIKGAAVSDYKTAVTACLDIKNCVGVTVWGVSDKDSWIKGSNPLLFDANFQAKDAYNGLCSILV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C3E7</accession>
    <name>A0A177C3E7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">RNA polymerase II subunit A C-terminal domain phosphatase SSU72</fullName>
            <shortName evidence="10">CTD phosphatase SSU72</shortName>
            <ecNumber evidence="10">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CC84DRAFT_1167352</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the cleavage and polyadenylation factor (CPF) complex, which plays a key role in polyadenylation-dependent pre-mRNA 3'-end formation and cooperates with cleavage factors including the CFIA complex and NAB4/CFIB. SSU72 is required for 3'-end formation of snoRNAs.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Processively dephosphorylates Ser-5 of the heptad repeats YSPTSPS in the C-terminal domain of the largest RNA polymerase II subunit (RPB1).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 14">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3 10">Component of the cleavage and polyadenylation factor (CPF) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the SSU72 phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="10"/>
    <dbReference type="EMBL" id="KV441556">
        <property type="protein sequence ID" value="OAG02264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032629.1">
        <property type="nucleotide sequence ID" value="XM_018179164.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C3E7"/>
    <dbReference type="FunCoup" id="A0A177C3E7">
        <property type="interactions" value="927"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177C3E7"/>
    <dbReference type="GeneID" id="28762650"/>
    <dbReference type="InParanoid" id="A0A177C3E7"/>
    <dbReference type="OrthoDB" id="57957at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0180007">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030643">
        <property type="term" value="P:intracellular phosphate ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032215">
        <property type="term" value="P:positive regulation of telomere maintenance via semi-conservative replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090052">
        <property type="term" value="P:regulation of pericentric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902801">
        <property type="term" value="P:regulation of siRNA-independent facultative heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009302">
        <property type="term" value="P:sno(s)RNA transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030847">
        <property type="term" value="P:termination of RNA polymerase II transcription, exosome-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030846">
        <property type="term" value="P:termination of RNA polymerase II transcription, poly(A)-coupled"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031564">
        <property type="term" value="P:transcription antitermination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001174">
        <property type="term" value="P:transcriptional start site selection at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000039">
        <property type="entry name" value="RNA polymerase II subunit A C-terminal domain phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000189">
        <property type="entry name" value="SSU72p Phosphatase and transcription/RNA-processing factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006811">
        <property type="entry name" value="RNA_pol_II_suA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20383">
        <property type="entry name" value="RNA POLYMERASE II SUBUNIT A C-TERMINAL DOMAIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04722">
        <property type="entry name" value="Ssu72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 10" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6 10" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="9"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="21"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="37"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU369031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OAG02264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="292" mass="31963" checksum="4B4D236C5C2BE6F7" modified="2016-09-07" version="1">MSDPRLRARAQQQQQQQLAPAPAPAPPPPPPPPMEPPVAVDGAPAAPAQDQAAVASDSNFKLKFCTVCASNQNRSMEAHLQLASANLPTISFGTGSLVRLPGPSITQPNVYKFNSTTYSAIHQELSNQNTQLYTANGLLNMLDRNLNIKSYPERFQDWIPGKPRLEHKDDQGFAGTEAGVVDVVITCEERCFDAVLEDLHNKGGRMNRPVHVFNVDIRDNHEEALVGGRGIRELALMLNEAAVQEMETHGDTGWDSGGGSARAGFDERVPDILAAWQEKWPNLPAIWSLAWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C3I1</accession>
    <name>A0A177C3I1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_1220328</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441556">
        <property type="protein sequence ID" value="OAG01956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032321.1">
        <property type="nucleotide sequence ID" value="XM_018183156.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C3I1"/>
    <dbReference type="GeneID" id="28766642"/>
    <dbReference type="InParanoid" id="A0A177C3I1"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF4">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="101"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="1"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAG01956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="192" mass="20975" checksum="6980C26EF74FDD84" modified="2016-09-07" version="1">MQPIDAGKRAGILAGDRGLRGVLTLQSFVTSFRVRYSPQDSRQQPSLQQLGAFLACFVAWPVTNRYGRHKTLALASAIFVVGADIQTIDTHAMGAFYPGRVIAGVGLGAATVVNLIYSSEMTAKHLRGQIAAFPCRTWSTMTFSKASLPKESMQWQIPIGLQIVPAALLGLSMLTLKESTRWLTQKDRHEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C457</accession>
    <name>A0A177C457_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1153697</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441557">
        <property type="protein sequence ID" value="OAG01679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032044.1">
        <property type="nucleotide sequence ID" value="XM_018176852.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C457"/>
    <dbReference type="STRING" id="1460663.A0A177C457"/>
    <dbReference type="GeneID" id="28760338"/>
    <dbReference type="InParanoid" id="A0A177C457"/>
    <dbReference type="OrthoDB" id="3219396at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25499">
        <property type="entry name" value="Beta-prop_pof12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="23"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="354"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="469"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="361"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG01679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="552" mass="61024" checksum="C8B5F12C9B8BCEC6" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C4L9</accession>
    <name>A0A177C4L9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Arabinanase/levansucrase/invertase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CC84DRAFT_1152754</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 43 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441556">
        <property type="protein sequence ID" value="OAG02366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032731.1">
        <property type="nucleotide sequence ID" value="XM_018176819.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C4L9"/>
    <dbReference type="STRING" id="1460663.A0A177C4L9"/>
    <dbReference type="GeneID" id="28760305"/>
    <dbReference type="InParanoid" id="A0A177C4L9"/>
    <dbReference type="OrthoDB" id="2139957at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18617">
        <property type="entry name" value="GH43_XynB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041542">
        <property type="entry name" value="GH43_C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006710">
        <property type="entry name" value="Glyco_hydro_43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051795">
        <property type="entry name" value="Glycosyl_Hydrlase_43"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42812">
        <property type="entry name" value="BETA-XYLOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42812:SF16">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G06110)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17851">
        <property type="entry name" value="GH43_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04616">
        <property type="entry name" value="Glyco_hydro_43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-xylosidase C-terminal Concanavalin A-like" evidence="5">
        <location>
            <begin position="362"/>
            <end position="560"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF17851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAG02366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="584" mass="66253" checksum="DE6645EF24D9D5A3" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C4Q2</accession>
    <name>A0A177C4Q2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1219582</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG02613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032978.1">
        <property type="nucleotide sequence ID" value="XM_018183089.1"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177C4Q2"/>
    <dbReference type="GeneID" id="28766575"/>
    <dbReference type="InParanoid" id="A0A177C4Q2"/>
    <dbReference type="OrthoDB" id="3922633at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="212"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="330"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="421"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="624"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="855"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="901"/>
            <end position="1034"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1048"/>
            <end position="1085"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1098"/>
            <end position="1153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1201"/>
            <end position="1229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1262"/>
            <end position="1297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="282"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="365"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="393"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="624"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="931"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1012"/>
            <end position="1022"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1062"/>
            <end position="1073"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1115"/>
            <end position="1124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1129"/>
            <end position="1148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1214"/>
            <end position="1224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1285"/>
            <end position="1297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG02613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="1297" mass="140510" checksum="DA528CB82660D880" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C4W3</accession>
    <name>A0A177C4W3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1262206</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441556">
        <property type="protein sequence ID" value="OAG02211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032576.1">
        <property type="nucleotide sequence ID" value="XM_018185133.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C4W3"/>
    <dbReference type="GeneID" id="28768619"/>
    <dbReference type="InParanoid" id="A0A177C4W3"/>
    <dbReference type="OrthoDB" id="3683032at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG02211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="236" mass="26684" checksum="C40CFC2AF54CD3FA" modified="2016-09-07" version="1" fragment="single">MSTGRSNAVDALPRASFLTYFRTPTKLNRRTGEDCQKRRASCRNHCSKAPLLPRIPEDATTEHTAEESEPEDYEHVDNHESGEEFEQGWSWTNILSFTGYTLLVLLIVLNLDFLLSAYNANAGLVKWDDHGVSTSSSSREMHFCLAEQNRLAPTSRVWRYVPRGSDSSCATRLLTIHADPTEEHKLFTEDIIMGEARNMPTCDSPNGESWGRSYRRSERLEVGDDLAQEGILSKEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C4X7</accession>
    <name>A0A177C4X7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">FAD-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CC84DRAFT_1097680</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG02794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033159.1">
        <property type="nucleotide sequence ID" value="XM_018174728.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C4X7"/>
    <dbReference type="STRING" id="1460663.A0A177C4X7"/>
    <dbReference type="GeneID" id="28758214"/>
    <dbReference type="InParanoid" id="A0A177C4X7"/>
    <dbReference type="OrthoDB" id="9983560at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050432">
        <property type="entry name" value="FAD-linked_Oxidoreductases_BP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13878:SF91">
        <property type="entry name" value="FAD BINDING DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G12070)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13878">
        <property type="entry name" value="GULONOLACTONE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008057817" evidence="3">
        <location>
            <begin position="19"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="4">
        <location>
            <begin position="117"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAG02794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="574" mass="63478" checksum="55F049A5058C1E85" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C5A0</accession>
    <name>A0A177C5A0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_975719</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441556">
        <property type="protein sequence ID" value="OAG01948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032313.1">
        <property type="nucleotide sequence ID" value="XM_018188026.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C5A0"/>
    <dbReference type="GeneID" id="28771512"/>
    <dbReference type="InParanoid" id="A0A177C5A0"/>
    <dbReference type="OrthoDB" id="5371016at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG01948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="265" mass="27925" checksum="E8012407F795F599" modified="2016-09-07" version="1">MGDRNPEHAVPAPAVALEGESTTRCSPGKRKRADTAQSAGTSIDALNSNIVAAGSETQSNGSATPPPKNGSKWVESEVSDVSMGADGAQSSDSVTPRTSVNGGAQEAEVPKITPSTTDATPGVSVTPYSNAEDIGKRKEMNTADVPAKTSYLPTARMSLWAGPVYIHIGDHEAIPDHAPPAMRFLKSYLPVVEGPQAESRAAHHHPTAMRKVNNDPPQVMNSSTPALPVQGTLPIQYESKLFRAWAIPNTGEPTMDAPRQTVLMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C5C1</accession>
    <name>A0A177C5C1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF1996 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1253075</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441556">
        <property type="protein sequence ID" value="OAG02351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032716.1">
        <property type="nucleotide sequence ID" value="XM_018184382.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C5C1"/>
    <dbReference type="STRING" id="1460663.A0A177C5C1"/>
    <dbReference type="GeneID" id="28767868"/>
    <dbReference type="InParanoid" id="A0A177C5C1"/>
    <dbReference type="OrthoDB" id="74764at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018535">
        <property type="entry name" value="DUF1996"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43662">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43662:SF13">
        <property type="entry name" value="DUF1996 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09362">
        <property type="entry name" value="DUF1996"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008057744" description="DUF1996 domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1996" evidence="2">
        <location>
            <begin position="34"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG02351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="342" mass="37850" checksum="7AD1C0078ED66C94" modified="2016-09-07" version="1">MHWTTSTLVALAFASPISALIRFQCSQLVVERLDPLVTPGQVPSPHVHQIVGGNSFNATMAPSKDMPGESTCTTCQFSEDFSNYWTAILYFRARNGTYKRVPQRSNAGFDGTTGGGMTVYYMTDPLYDSQPKSKVSAFKPGFRMFVGDINARTKEQAARFRQLTYTCMENAGSREHEVVHFPQKPCSYGIMTSVRFPTCWDGVNLDSPDHMAHMSYPESGTFESAGPCPSTHPVRVSQVLFEVIWDTSKFNDPADWPEDGSQPFVWSFGDPTGYANHADYVFGWKDDSLQKILDTSCYATSCGGKQQSIAEMNKCAGLKKTVDEDIGEDTWLTQLPGGHAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C5V7</accession>
    <name>A0A177C5V7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_982009</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441556">
        <property type="protein sequence ID" value="OAG02070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032435.1">
        <property type="nucleotide sequence ID" value="XM_018188045.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C5V7"/>
    <dbReference type="GeneID" id="28771531"/>
    <dbReference type="InParanoid" id="A0A177C5V7"/>
    <dbReference type="OrthoDB" id="4889334at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006764">
        <property type="entry name" value="SAM_dep_MeTrfase_SAV2177_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04672">
        <property type="entry name" value="Methyltransf_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG02070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="161" mass="17562" checksum="67EE49F7929E78FA" modified="2016-09-07" version="1">MPIGVLNTRLYINTYDICFAKRNNGSTPALQHYPNGLDDPSKEAPKPLLRDRPPGSHGSGSKFPRIIHTAVENRIFLRRMVCWLAPNGVTQFVDLGSAPSTTAGTQETVLKVAPDVRVLYVDADVSAVNEGQKYIRETGCEEQVGMIQASALDPDAVIEDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C6A7</accession>
    <name>A0A177C6A7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1166507</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG02671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033036.1">
        <property type="nucleotide sequence ID" value="XM_018178975.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C6A7"/>
    <dbReference type="GeneID" id="28762461"/>
    <dbReference type="InParanoid" id="A0A177C6A7"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG02671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="95" mass="10377" checksum="6FA330943CC04E4F" modified="2016-09-07" version="1">MTMTPRPSKPPDVSAGGVSWALPDHFNASPSSTLLPRRIVSLEQPASPQERHSTRSSSTQPRRATALHRHTSARWRSQQSSLRAKEAVNAHCAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C6Z3</accession>
    <name>A0A177C6Z3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein SDS23</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Protein sds23</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CC84DRAFT_1124229</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Involved in DNA replication and cell separation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the SDS23 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG02517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032882.1">
        <property type="nucleotide sequence ID" value="XM_018175681.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C6Z3"/>
    <dbReference type="FunCoup" id="A0A177C6Z3">
        <property type="interactions" value="211"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177C6Z3"/>
    <dbReference type="GeneID" id="28759167"/>
    <dbReference type="InParanoid" id="A0A177C6Z3"/>
    <dbReference type="OrthoDB" id="449052at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004865">
        <property type="term" value="F:protein serine/threonine phosphatase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042149">
        <property type="term" value="P:cellular response to glucose starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030071">
        <property type="term" value="P:regulation of mitotic metaphase/anaphase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02205">
        <property type="entry name" value="CBS_pair_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050511">
        <property type="entry name" value="AMPK_gamma/SDS23_families"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016711">
        <property type="entry name" value="Ssd23"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13780">
        <property type="entry name" value="AMP-ACTIVATED PROTEIN KINASE, GAMMA REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13780:SF36">
        <property type="entry name" value="CBS DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018148">
        <property type="entry name" value="UCP018148_CBS_YBR214w"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0129">CBS domain</keyword>
    <keyword evidence="6 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="CBS" evidence="12">
        <location>
            <begin position="193"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="12">
        <location>
            <begin position="269"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="463"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="58"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="494"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR018148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OAG02517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="530" mass="56281" checksum="BBBF4B4EDF021C9A" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C703</accession>
    <name>A0A177C703_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HNH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_896916</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG02527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032892.1">
        <property type="nucleotide sequence ID" value="XM_018187826.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C703"/>
    <dbReference type="STRING" id="1460663.A0A177C703"/>
    <dbReference type="GeneID" id="28771312"/>
    <dbReference type="InParanoid" id="A0A177C703"/>
    <dbReference type="OrthoDB" id="4850648at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37827:SF1">
        <property type="entry name" value="HNH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37827">
        <property type="entry name" value="TUDOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG02527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="275" mass="30889" checksum="2DA6D7063E92F32C" modified="2016-09-07" version="1">MADAIAPNEQHNFETFRDCFSEPVLKALSKPIDKPKKKRRLPRKSKDGRNGIPKKKANIDAGQAVSTEDQTSAEDLGDFIDYLSTLIFPSLPPDFRILSYSKYRDEPHLQDRYSTPLSHLTETHLLNLLPPPALDSLTSYALLPAVPDPLDLHHFFTPVFTSYIAAATAPPPIWSATRTSACELCARDWIPLTYHHLIPKSTHERVRKRGWHAEESLNSVAWLCRACHSFVHRLAGNEELARGWYTVELIVRGGVDGEYIVILVMGKGWKVAGNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C794</accession>
    <name>A0A177C794_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_901987</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG02617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032982.1">
        <property type="nucleotide sequence ID" value="XM_018187849.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C794"/>
    <dbReference type="GeneID" id="28771335"/>
    <dbReference type="InParanoid" id="A0A177C794"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG02617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="85" mass="9116" checksum="029E304CFA49E832" modified="2016-09-07" version="1">MTSWCSFGRQNTSQGLGPNELSAFSRVALIAAGLKFWATAHECPFKRVACASLVAARLFLTLVPRLGAFASPGEDVTLIALRYAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C7F1</accession>
    <name>A0A177C7F1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CC84DRAFT_1207548</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG02677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033042.1">
        <property type="nucleotide sequence ID" value="XM_018182108.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C7F1"/>
    <dbReference type="STRING" id="1460663.A0A177C7F1"/>
    <dbReference type="GeneID" id="28765594"/>
    <dbReference type="InParanoid" id="A0A177C7F1"/>
    <dbReference type="OrthoDB" id="10018191at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051059">
        <property type="entry name" value="VerF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626">
        <property type="entry name" value="MIP31509P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626:SF13">
        <property type="entry name" value="RESPIRATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="5"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="33"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="55"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="118"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="55"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="68"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="83"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="121"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAG02677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="820" mass="92553" checksum="89B159D6F18886D4" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C7M0</accession>
    <name>A0A177C7M0_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7730 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_934886</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG02842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033207.1">
        <property type="nucleotide sequence ID" value="XM_018187903.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C7M0"/>
    <dbReference type="STRING" id="1460663.A0A177C7M0"/>
    <dbReference type="GeneID" id="28771389"/>
    <dbReference type="InParanoid" id="A0A177C7M0"/>
    <dbReference type="OrthoDB" id="3801532at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056632">
        <property type="entry name" value="DUF7730"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38790">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24864">
        <property type="entry name" value="DUF7730"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7730" evidence="2">
        <location>
            <begin position="42"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG02842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="180" mass="21061" checksum="ABFBC5E7F91AAC62" modified="2016-09-07" version="1">MFAWFRSLLSPNPPITNRGRQRALKSRRRSLSVDRKGRKMKRQAQSPLFSMLPPEIRFMIYEMVLCETSQVHIIVKGSKRGSDTTEMYGRTCAEPRRYCPPGSRCRVQSQLLLTCRMVYCEAIDILYSRNAFIFQSEYDFVLFGRLTVPHHLRKIKKVCIGTFDYEGKPQFKSLPLELLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C7X5</accession>
    <name>A0A177C7X5_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Extracellular membrane protein CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1207747</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG02952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033317.1">
        <property type="nucleotide sequence ID" value="XM_018182120.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C7X5"/>
    <dbReference type="GeneID" id="28765606"/>
    <dbReference type="InParanoid" id="A0A177C7X5"/>
    <dbReference type="OrthoDB" id="3775550at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008057849" description="Extracellular membrane protein CFEM domain-containing protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG02952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="237" mass="25929" checksum="60B4C8735B1D4A3C" modified="2016-09-07" version="1">MHLPTFLTSLLFLATSTSTTATPLAKRWECSSSAPGAFSCYPSNIDSCKNVAGWVSCAQTEGIDKCKDPAPSETVPVSQCQGDAFAKCGLRVVILMPPRKLCVIFAANRPVAMFPQSAAIHSRGFTWICSLSNVAAGGPSSIVSVLFHNDFIIPTGQLAHIQTRARIPVLLPFMCETVKGFYEENKSERDYVLNDGICKIWAYSATDFHRHIEWGGGSLYDWIVLMGFGVIEHAFRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C9Z7</accession>
    <name>A0A177C9Z7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Membrane insertase YidC/Oxa/ALB C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CC84DRAFT_791611</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the OXA1/ALB3/YidC family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG04405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034770.1">
        <property type="nucleotide sequence ID" value="XM_018187407.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C9Z7"/>
    <dbReference type="STRING" id="1460663.A0A177C9Z7"/>
    <dbReference type="GeneID" id="28770893"/>
    <dbReference type="InParanoid" id="A0A177C9Z7"/>
    <dbReference type="OrthoDB" id="2148490at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032977">
        <property type="term" value="F:membrane insertase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032979">
        <property type="term" value="P:protein insertion into mitochondrial inner membrane from matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20069">
        <property type="entry name" value="5TM_Oxa1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001708">
        <property type="entry name" value="YidC/ALB3/OXA1/COX18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028055">
        <property type="entry name" value="YidC/Oxa/ALB_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12428:SF66">
        <property type="entry name" value="MITOCHONDRIAL INNER MEMBRANE PROTEIN OXA1L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12428">
        <property type="entry name" value="OXA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02096">
        <property type="entry name" value="60KD_IMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Membrane insertase YidC/Oxa/ALB C-terminal" evidence="11">
        <location>
            <begin position="199"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="17"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="433"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="17"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="502"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OAG04405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="536" mass="58330" checksum="B175CF6C68B5D525" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2023-06-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CAA7</accession>
    <name>A0A177CAA7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_863390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG03697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034062.1">
        <property type="nucleotide sequence ID" value="XM_018187686.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CAA7"/>
    <dbReference type="GeneID" id="28771172"/>
    <dbReference type="InParanoid" id="A0A177CAA7"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008058008" evidence="1">
        <location>
            <begin position="19"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG03697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="97" mass="10755" checksum="5C7EC7DCDD2538A5" modified="2016-09-07" version="1">MLLIAFIGLHSQSYGAQTWPCNVGTSAKVRQDMLEIPLELFSTLDRQRAISYLLGANRRHLPHEVFACPPELIWPPGDLRSGVTALGDCAHVLERTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CAG4</accession>
    <name>A0A177CAG4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Amino acid permease/ SLC12A domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CC84DRAFT_1177673</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG03710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034075.1">
        <property type="nucleotide sequence ID" value="XM_018180296.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CAG4"/>
    <dbReference type="FunCoup" id="A0A177CAG4">
        <property type="interactions" value="155"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CAG4"/>
    <dbReference type="GeneID" id="28763782"/>
    <dbReference type="InParanoid" id="A0A177CAG4"/>
    <dbReference type="OrthoDB" id="3900342at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000006">
        <property type="entry name" value="General amino acid permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF4">
        <property type="entry name" value="ARGININE PERMEASE CAN1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="45"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="123"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="153"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="187"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="234"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="275"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="315"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="371"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="401"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="445"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="477"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="9">
        <location>
            <begin position="44"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAG03710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="543" mass="59424" checksum="3815D0DE1E9C5776" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CAH8</accession>
    <name>A0A177CAH8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PAL-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1166244</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PAL/histidase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG04141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034506.1">
        <property type="nucleotide sequence ID" value="XM_018178909.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CAH8"/>
    <dbReference type="STRING" id="1460663.A0A177CAH8"/>
    <dbReference type="GeneID" id="28762395"/>
    <dbReference type="InParanoid" id="A0A177CAH8"/>
    <dbReference type="OrthoDB" id="10051290at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00332">
        <property type="entry name" value="PAL-HAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.200.10">
        <property type="entry name" value="Fumarase/aspartase (Central domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="entry name" value="Fumarase/aspartase (N-terminal domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.20">
        <property type="entry name" value="Phenylalanine ammonia-lyase 1, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001106">
        <property type="entry name" value="Aromatic_Lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023144">
        <property type="entry name" value="Phe_NH3-lyase_shielding_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10362">
        <property type="entry name" value="HISTIDINE AMMONIA-LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00221">
        <property type="entry name" value="Lyase_aromatic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="L-aspartase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG04141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="605" mass="66046" checksum="EE4A41A606D93CBF" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CAY1</accession>
    <name>A0A177CAY1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ATP12-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CC84DRAFT_1207164</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATP12 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG03927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034292.1">
        <property type="nucleotide sequence ID" value="XM_018182079.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CAY1"/>
    <dbReference type="FunCoup" id="A0A177CAY1">
        <property type="interactions" value="671"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CAY1"/>
    <dbReference type="GeneID" id="28765565"/>
    <dbReference type="InParanoid" id="A0A177CAY1"/>
    <dbReference type="OrthoDB" id="5322896at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033615">
        <property type="term" value="P:mitochondrial proton-transporting ATP synthase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3580.10">
        <property type="entry name" value="ATP12 ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2180.10">
        <property type="entry name" value="ATP12-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011419">
        <property type="entry name" value="ATP12_ATP_synth-F1-assembly"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042272">
        <property type="entry name" value="ATP12_ATP_synth-F1-assembly_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023335">
        <property type="entry name" value="ATP12_ortho_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21013:SF10">
        <property type="entry name" value="ATP SYNTHASE MITOCHONDRIAL F1 COMPLEX ASSEMBLY FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21013">
        <property type="entry name" value="ATP SYNTHASE MITOCHONDRIAL F1 COMPLEX ASSEMBLY FACTOR 2/ATP12 PROTEIN, MITOCHONDRIAL PRECURSOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07542">
        <property type="entry name" value="ATP12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160909">
        <property type="entry name" value="ATP12-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="31"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="38"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAG03927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="361" mass="39754" checksum="392CE7B4AF39A2CA" modified="2016-09-07" version="1">MESIRPALATLRLQATRRAPRPLYQCLHTTASRRATPLPHPSVPGPPPATPTPSPTDALYRVARKKKQASLLQQAKDIRAAPKPGGALAKRFWKDVTVKEADGGLQVFLDSRPVRTPTKEILTVPATKHQLASAIALEWDLLLSAQQALKTHYIPMTSLAARAKDIEKADAEGNSKVRDDIIRMLMRYLSTDTLLCWAPEKQLHEVPQGGLTLRQTQMKLTMPIIAHLTTHVWPGVEIKPILEPDSIMPVSQPEMTQDVIRGWLAGIPSFELAGLERAVLASKSLLIGVRLVHEWAEAFAQSREASDGGRFGIEEAAEAASTEVRWQTGQWGEVEDTHDVEKEDMKRQLGSVILLVGGETS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CB02</accession>
    <name>A0A177CB02_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Aspartate aminotransferase</fullName>
            <ecNumber evidence="7">2.6.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CC84DRAFT_883673</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:21824"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="EC" id="2.6.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3 7">Homodimer.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="7">In eukaryotes there are cytoplasmic, mitochondrial and chloroplastic isozymes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.1" evidence="7"/>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG04032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034397.1">
        <property type="nucleotide sequence ID" value="XM_018187778.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CB02"/>
    <dbReference type="FunCoup" id="A0A177CB02">
        <property type="interactions" value="859"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CB02"/>
    <dbReference type="GeneID" id="28771264"/>
    <dbReference type="InParanoid" id="A0A177CB02"/>
    <dbReference type="OrthoDB" id="6752799at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004069">
        <property type="term" value="F:L-aspartate:2-oxoglutarate aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006532">
        <property type="term" value="P:aspartate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000064">
        <property type="entry name" value="Aspartate aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000001">
        <property type="entry name" value="Aspartate aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000796">
        <property type="entry name" value="Asp_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006719">
        <property type="entry name" value="PRK09257.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11879">
        <property type="entry name" value="ASPARTATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11879:SF55">
        <property type="entry name" value="GLUTAMATE OXALOACETATE TRANSAMINASE 1, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00799">
        <property type="entry name" value="TRANSAMINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="9">
        <location>
            <begin position="62"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="9"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAG04032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="468" mass="51879" checksum="181D5150F1110B07" modified="2016-09-07" version="1">MPASPHYNSSPSSLSPQSRLSQLSQHIAPMTTTSFSAEVVPQAPEDPLFGLMAAFRRDEDPKKVDLGIGAYRDDNAKPWVLPVVKKVRANSCRRGELPNSSRWDADSSLQADDIIRNDPNLNHEYLPIAGLADFTSASQKLILGGDSPALKEKRVTSLQTVSGTGAVHLGALFLAKFYKPASKPTAYFSDPTWPNHFQIFSNVGLSHKTYPYFSKETKGLDFDGFYNSIQNADEGSIVVLHACAHNPTGVDLTQDQWKKIAEVIRAKKHFPFFDTAYQGFASGDLARDGWAIRYFVEQGFELCIAQSYAKNFGLYGERAGCFHFVTSPSSDAQSTIGRIASQLAILQRSEISNPPAYGARIASLVLNTPELFAQWEEDLRTMSGRIIEMRKALRSKLEELGTPGTWNHITDQIGMFSFTGLSEQQVMKLREDSHVYMTKNGRISMAGLNTKNIDYFAKAVDKAVRDTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CB74</accession>
    <name>A0A177CB74_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DUF1687-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CC84DRAFT_1165281</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Putative mitochondrial redox protein which could be involved in the reduction of small toxic molecules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FMP46 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG04924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035289.1">
        <property type="nucleotide sequence ID" value="XM_018178683.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CB74"/>
    <dbReference type="GeneID" id="28762169"/>
    <dbReference type="InParanoid" id="A0A177CB74"/>
    <dbReference type="OrthoDB" id="59229at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006660">
        <property type="entry name" value="Arsenate_reductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012882">
        <property type="entry name" value="Fmp46"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28071">
        <property type="entry name" value="REDOX PROTEIN FMP46, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28071:SF1">
        <property type="entry name" value="REDOX PROTEIN FMP46, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07955">
        <property type="entry name" value="DUF1687"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51353">
        <property type="entry name" value="ARSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAG04924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="149" mass="16160" checksum="3A8B2681B8CF6D49" modified="2016-09-07" version="1">MFKRIFGEHGAKNVVTLFHKPSSTASTRVLTLLKQTNAQSVAHATEDQASSHQAQDKAERMEFELDVTEAPPTADQLKSILDYLGGSGAASKVVSGAQDETDAMRRLKADGETFLRPVVVDWNQGKAVVGESESEILSMLRSISKDNKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CBK0</accession>
    <name>A0A177CBK0_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF4336 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1165010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG04571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034936.1">
        <property type="nucleotide sequence ID" value="XM_018178621.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CBK0"/>
    <dbReference type="GeneID" id="28762107"/>
    <dbReference type="InParanoid" id="A0A177CBK0"/>
    <dbReference type="OrthoDB" id="421671at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025638">
        <property type="entry name" value="DUF4336"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33835:SF1">
        <property type="entry name" value="METALLO-BETA-LACTAMASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33835">
        <property type="entry name" value="YALI0C07656P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14234">
        <property type="entry name" value="DUF4336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG04571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="269" mass="30110" checksum="2E45AF52C50A7131" modified="2016-09-07" version="1">MSSKLVPSNPAEVMVIRDIVPRTITTLSVPFARFGRIKVGGRGTIVRLQNGSLAVFSPVALTDEVKQKVAEMGEVKYITALDIEHHIFLGPWHAAYPNAQVLGPEGLPEKRKSQNKEAVPFAHLFSKDKPVTSIDPDFDREFEWEYVPAHTNKEIVFNHKPTRTLIEADLMFNYPSTEQYSKTGLSATSGVLTKIFGMLTNTSGKGQQRAIWYGISSRDRAGFSRSVSKIHQWDFDRIIPCHGDVLESGGKGIFAKVMEWHLELAKKRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CBL1</accession>
    <name>A0A177CBL1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">FAD binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CC84DRAFT_1148087</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG05005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035370.1">
        <property type="nucleotide sequence ID" value="XM_018176618.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CBL1"/>
    <dbReference type="STRING" id="1460663.A0A177CBL1"/>
    <dbReference type="GeneID" id="28760104"/>
    <dbReference type="InParanoid" id="A0A177CBL1"/>
    <dbReference type="OrthoDB" id="9983560at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050432">
        <property type="entry name" value="FAD-linked_Oxidoreductases_BP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13878:SF91">
        <property type="entry name" value="FAD BINDING DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G12070)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13878">
        <property type="entry name" value="GULONOLACTONE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008058064" evidence="3">
        <location>
            <begin position="25"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="4">
        <location>
            <begin position="143"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAG05005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="611" mass="67564" checksum="2D4CA07AD211D6E7" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CDC1</accession>
    <name>A0A177CDC1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="3">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CC84DRAFT_1145197</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="3"/>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG05644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036009.1">
        <property type="nucleotide sequence ID" value="XM_018176497.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CDC1"/>
    <dbReference type="STRING" id="1460663.A0A177CDC1"/>
    <dbReference type="GeneID" id="28759983"/>
    <dbReference type="InParanoid" id="A0A177CDC1"/>
    <dbReference type="OrthoDB" id="6287070at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF722">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="USP" evidence="9">
        <location>
            <begin position="115"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="315"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="498"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="560"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="731"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="11"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="501"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="570"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="606"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="625"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="678"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="788"/>
            <end position="797"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAG05644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="797" mass="89854" checksum="E0CC0975ECE7B0D0" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CDF5</accession>
    <name>A0A177CDF5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CC84DRAFT_1093518</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Mycotoxin biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG05261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035626.1">
        <property type="nucleotide sequence ID" value="XM_018174518.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CDF5"/>
    <dbReference type="STRING" id="1460663.A0A177CDF5"/>
    <dbReference type="GeneID" id="28758004"/>
    <dbReference type="InParanoid" id="A0A177CDF5"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902181">
        <property type="term" value="P:verruculogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11058">
        <property type="entry name" value="CYP60B-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000063">
        <property type="entry name" value="Cytochrome P450 monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF210">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE ASQL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13 14" id="KW-0349">Heme</keyword>
    <keyword evidence="10 13 14" id="KW-0408">Iron</keyword>
    <keyword evidence="12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 14" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="13">
        <location>
            <position position="453"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OAG05261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="517" mass="58238" checksum="D60802E5BAE32E6A" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CDP6</accession>
    <name>A0A177CDP6_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Azaphilone pigments biosynthesis cluster protein L N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_1093548</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG04888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035253.1">
        <property type="nucleotide sequence ID" value="XM_018174523.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CDP6"/>
    <dbReference type="STRING" id="1460663.A0A177CDP6"/>
    <dbReference type="GeneID" id="28758009"/>
    <dbReference type="InParanoid" id="A0A177CDP6"/>
    <dbReference type="OrthoDB" id="432483at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031348">
        <property type="entry name" value="PigL_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17111">
        <property type="entry name" value="PigL_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Azaphilone pigments biosynthesis cluster protein L N-terminal" evidence="3">
        <location>
            <begin position="2"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="241"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="202"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="241"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="257"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAG04888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="281" mass="30784" checksum="833E274A1F4FD071" modified="2016-09-07" version="1">MADPLSITAGAVGITVPALHGIRLLMEDLQQLKDAPKTIKRLVEDVRSVDTALSLLQGVEDREWTLLGAIIAKESEKTISSCKQACDLFRTNLQRWTKNSEDGKLGWKDRTNVGFFKQGPIKAMSEQLQNCKLTINSVVSIATLYSSVRHNHITEDIKKTISTKQEEVKEAITATHKQMIVLENKLEELNLSSDDEDMAGPEAGKAETVRQLEEERKALEASRTLLDELLSRAREEAVAKAAAKSQDSSTTVSTVTFGNQNSGQQAGVINGGVHGAVFRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CDT1</accession>
    <name>A0A177CDT1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SAICAR synthase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CC84DRAFT_1165404</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG05072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035437.1">
        <property type="nucleotide sequence ID" value="XM_018178705.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CDT1"/>
    <dbReference type="STRING" id="1460663.A0A177CDT1"/>
    <dbReference type="GeneID" id="28762191"/>
    <dbReference type="InParanoid" id="A0A177CDT1"/>
    <dbReference type="OrthoDB" id="70770at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016308">
        <property type="term" value="F:1-phosphatidylinositol-4-phosphate 5-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.810.10">
        <property type="entry name" value="2-Layer Sandwich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.800.10">
        <property type="entry name" value="Phosphatidylinositol Phosphate Kinase II Beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027483">
        <property type="entry name" value="PInositol-4-P-4/5-kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002498">
        <property type="entry name" value="PInositol-4-P-4/5-kinase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027484">
        <property type="entry name" value="PInositol-4-P-5-kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023610">
        <property type="entry name" value="PInositol-4/5-P-5/4-kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23086">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-4-PHOSPHATE 5-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23086:SF126">
        <property type="entry name" value="PIPK DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01504">
        <property type="entry name" value="PIP5K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00330">
        <property type="entry name" value="PIPKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56104">
        <property type="entry name" value="SAICAR synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51455">
        <property type="entry name" value="PIPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="31"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="domain" description="PIPK" evidence="4">
        <location>
            <begin position="1"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="356"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="357"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAG05072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="379" mass="43145" checksum="1527F98EE4E45E53" modified="2016-09-07" version="1">MGRRQRLISKSILRAIFSPKRAYGTDDRPSLLARILAFFAVFNLTLARYRAALFRRLRNEIWEIDEEEYTESFRSTSHNKRTDLVAVGDLGYSGSTFFTTPNSKFLLKSLPRHFEQSFFRDRLLNPYVEHMELNPGSLLVRITDLLYSPAPTIGAALGTAPGHHIVMENILYGKSECSTDDQEQWETYDLKPNDYFYPERDVAGGRLAPESVKDRLIDEFPDKVRLTIDQKEDLVAQITKDTKILQENNAVDYSLFLVRYPASTASTYNVPVPPGKDAPWRTGLTSNDGKWVYRAILLDFFWAKDAVQAMAMTGLVNTFNFLKWGRDHGPMSITTTSDEYRTRFLRMVDDMIEVPDSSGQPAGQLRSQPPSTGDLIGEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CE58</accession>
    <name>A0A177CE58_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF453-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1093878</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PrpF family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG05202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035567.1">
        <property type="nucleotide sequence ID" value="XM_018174542.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CE58"/>
    <dbReference type="STRING" id="1460663.A0A177CE58"/>
    <dbReference type="GeneID" id="28758028"/>
    <dbReference type="InParanoid" id="A0A177CE58"/>
    <dbReference type="OrthoDB" id="10267539at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.310.10">
        <property type="entry name" value="Diaminopimelate Epimerase, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007400">
        <property type="entry name" value="PrpF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43709">
        <property type="entry name" value="ACONITATE ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43709:SF2">
        <property type="entry name" value="DUF453 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G00360)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04303">
        <property type="entry name" value="PrpF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54506">
        <property type="entry name" value="Diaminopimelate epimerase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG05202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="323" mass="34542" checksum="6AC27DC157C9ECBB" modified="2016-09-07" version="1" fragment="single">MGNICLVEPYHQTKEDDATSPHVDYTYVSVDAKYGDLDVEANSGNLLSAVGPYAYNARLLPPDLYAIKDGEITITIRNTNTMMLVESTFSVVGGQAAVTGSHKVDGVNGKGAKISLSFRDPTCSTTGKRFPTGRAVDMVEGYEVTCVDGAVPVVFIRADAVGVPGTILPHELTQNKDAMELLENIRRAAAVEMGIADTKKTALRTIPKIAIVSQSCRHSTVSGSPLVSSQMDLVVRFISDTEPHPAIPLTGALTTAVAARMPRTVVEQLLAPEEVMPGTLTIAHPSGRIQVKLDYEAGTKPSVWVAKVSSTAQRLFQGNAFWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CE90</accession>
    <name>A0A177CE90_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">D-arabinono-1,4-lactone oxidase</fullName>
            <ecNumber evidence="2">1.1.3.37</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">L-galactono-gamma-lactone oxidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CC84DRAFT_1244755</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; D-erythroascorbate biosynthesis; dehydro-D-arabinono-1,4-lactone from D-arabinose: step 2/2.</text>
    </comment>
    <dbReference type="EC" id="1.1.3.37" evidence="2"/>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG05944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036309.1">
        <property type="nucleotide sequence ID" value="XM_018184162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CE90"/>
    <dbReference type="STRING" id="1460663.A0A177CE90"/>
    <dbReference type="GeneID" id="28767648"/>
    <dbReference type="InParanoid" id="A0A177CE90"/>
    <dbReference type="OrthoDB" id="371463at2759"/>
    <dbReference type="UniPathway" id="UPA00771">
        <property type="reaction ID" value="UER00766"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003885">
        <property type="term" value="F:D-arabinono-1,4-lactone oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="entry name" value="Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007173">
        <property type="entry name" value="ALO_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010031">
        <property type="entry name" value="FAD_lactone_oxidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43762:SF1">
        <property type="entry name" value="D-ARABINONO-1,4-LACTONE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43762">
        <property type="entry name" value="L-GULONOLACTONE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04030">
        <property type="entry name" value="ALO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008058044" description="D-arabinono-1,4-lactone oxidase" evidence="5">
        <location>
            <begin position="19"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="6">
        <location>
            <begin position="31"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00033418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAG05944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="510" mass="56650" checksum="8908E3972E0D4B4D" modified="2016-09-07" version="1">MAYRCVLGLLTLALSCRAEPFNTFDGPGHPACNNVAKVYNATSVEEMQTIVRDAAESNTPVRASGKGHMWYDTMCSDDPTTVIIRTEDVNKISDLDLPEGASEGSVMIEAGVTFLQLAEYLHTNGASVGYTLVNWNITLAGSIAMGAHRSSLREDSMVAAGALELHIIDGKGNITVVKRDNSNDDWLAASTSLGLLGVIARIKFKVYPDFKVYAQQKILAEDQVLNGDIYGMIQPYATANLWWWPFLKKFHHRYYDKVDINNSTQEGFQSTFSVTKTEADLALGILNAGKYLATSNQLAETTFFALWSAPNFHEKTTDKAILTWPVYGWNYDVLIGGLYPGYGTEWDYGLRGLTLELAFPVTQANAVLKRVRKAFDDSAAAGKPMTSTYRSGINIKFGKAYFDLLGQVTTNTSDGADWSKGAIMFDFPSFQPTIGDKLRYNEPFYHNLAQALITEFPCRPHWTKNTREVFTLAKDKIDASHLARFKKVREKFDPNGIFKSIVGQILGLYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CEC8</accession>
    <name>A0A177CEC8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">SWIRM-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CC84DRAFT_1090771</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG05984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036349.1">
        <property type="nucleotide sequence ID" value="XM_018174373.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CEC8"/>
    <dbReference type="FunCoup" id="A0A177CEC8">
        <property type="interactions" value="430"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CEC8"/>
    <dbReference type="GeneID" id="28757859"/>
    <dbReference type="InParanoid" id="A0A177CEC8"/>
    <dbReference type="OrthoDB" id="118550at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016514">
        <property type="term" value="C:SWI/SNF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000020">
        <property type="entry name" value="SWI/SNF complex subunit SMARCC2 isoform c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000014">
        <property type="entry name" value="SWI/SNF complex subunit SMARCC2 isoform C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017884">
        <property type="entry name" value="SANT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032451">
        <property type="entry name" value="SMARCC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007526">
        <property type="entry name" value="SWIRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12802:SF41">
        <property type="entry name" value="BRAHMA ASSOCIATED PROTEIN 155 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12802">
        <property type="entry name" value="SWI/SNF COMPLEX-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04433">
        <property type="entry name" value="SWIRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16495">
        <property type="entry name" value="SWIRM-assoc_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51293">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50934">
        <property type="entry name" value="SWIRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="SWIRM" evidence="7">
        <location>
            <begin position="130"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="SANT" evidence="8">
        <location>
            <begin position="398"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="6">
        <location>
            <begin position="402"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="247"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="525"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="80"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="94"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="293"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="534"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAG05984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="728" mass="79624" checksum="BF5354D6172AE4E9" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CEE0</accession>
    <name>A0A177CEE0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1164146</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG05676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036041.1">
        <property type="nucleotide sequence ID" value="XM_018178425.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CEE0"/>
    <dbReference type="STRING" id="1460663.A0A177CEE0"/>
    <dbReference type="GeneID" id="28761911"/>
    <dbReference type="InParanoid" id="A0A177CEE0"/>
    <dbReference type="OrthoDB" id="3928876at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16015">
        <property type="entry name" value="Promethin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="49"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="79"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="110"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG05676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="258" mass="28026" checksum="279670271B44DD1D" modified="2016-09-07" version="1">MSGLLNSVQSILGKLWTNTANGFDKILPPDRRDELLSKLQDFANKNPKLAAFLATHVVLTGIPLVLFTFFILSVFVFSLITALLASILAAVFFTLFMVGVALLFLVPTLFLTTFTASFVFLWGLGGWFVLKWFTQEGSASDRKRFTSRADGFTGGRAEWVGRGAGEKRVLTHSSDEEGAERQSDSHRLSEMANVKASGTAAGRELEKVTESLEDETNRQPLHLPVKILKIVEAEENAAGAENSVVADAKETVGGAAET</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2023-06-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CFK7</accession>
    <name>A0A177CFK7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_723945</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG05507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035872.1">
        <property type="nucleotide sequence ID" value="XM_018187181.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CFK7"/>
    <dbReference type="GeneID" id="28770667"/>
    <dbReference type="InParanoid" id="A0A177CFK7"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG05507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="184" mass="19704" checksum="E625D4F2CA576862" modified="2016-09-07" version="1">MPQEAHPHTMQLETNPGAATKPAARLDRTPVPSPIGIKMPRAHAEMPTWSNPGPLSRLSHPPSAHAHGWHAAHTLCTWQGSLSQCPSLLAHLKTACLAPSIARSSFITPWLHGDCSPCSASPRSRSPASLPVSSLFGILHSTVILAPRGMSRIAFDSQIYVYVHPPNSPPTTSGATRYTLHLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CG04</accession>
    <name>A0A177CG04_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1216977</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG05647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036012.1">
        <property type="nucleotide sequence ID" value="XM_018182853.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CG04"/>
    <dbReference type="GeneID" id="28766339"/>
    <dbReference type="InParanoid" id="A0A177CG04"/>
    <dbReference type="OrthoDB" id="3713270at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG05647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="176" mass="20549" checksum="1352235837844809" modified="2016-09-07" version="1">MSMRDLRLLAENARRVEEVILDIERAFIPVVRGEMCVASWGGKECRIYSVDTSHPAILTPTERARVFWAYYQVMRLMLCDEDTIFAEMALMRLRNLFYVNEMAHWIRARCADWGLIYVVRASGRAIERVYQEQYGCAAPEFQSPLDFERPVVLFVVWDCWQGRLDNIVRRGSEGDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CGL4</accession>
    <name>A0A177CGL4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fungal STAND N-terminal Goodbye domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_619656</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG06723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037088.1">
        <property type="nucleotide sequence ID" value="XM_018186900.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CGL4"/>
    <dbReference type="STRING" id="1460663.A0A177CGL4"/>
    <dbReference type="GeneID" id="28770386"/>
    <dbReference type="InParanoid" id="A0A177CGL4"/>
    <dbReference type="OrthoDB" id="3730111at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40619">
        <property type="entry name" value="FUNGAL STAND N-TERMINAL GOODBYE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40619:SF3">
        <property type="entry name" value="FUNGAL STAND N-TERMINAL GOODBYE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG06723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="647" mass="72218" checksum="8752C8516A0D63E0" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CGL5</accession>
    <name>A0A177CGL5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1217144</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG05837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036202.1">
        <property type="nucleotide sequence ID" value="XM_018182867.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CGL5"/>
    <dbReference type="GeneID" id="28766353"/>
    <dbReference type="InParanoid" id="A0A177CGL5"/>
    <dbReference type="OrthoDB" id="3796252at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="249"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="14"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG05837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="283" mass="31125" checksum="F24DFFA868AA7E4F" modified="2016-09-07" version="1">MARLNPNPAPAPSPRACSAPVPASARLKSTYTPSSPTSSRTKGSRTSSGDARAGAEQDEKREQTHASSRSLLDECREDKHRPRLIIARVSRAAANLTLRKRRSPQKQASAPDLARIYPFLENVVVVEVPDDSDSDADSERTKEIRYENEHGWEAYIGCGIGEESSLFETEIECQKQEEEDEQTCDTEKIGSNGNKSEDDDDDDDDDDSAYGSFNIEVPEAACPTFITREDSHWTYAAICAWRDNVCAGSPSPPPSKALPSITVRKRPTPRTPGKSPGKRLLTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CHU6</accession>
    <name>A0A177CHU6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1196404</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG06347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036712.1">
        <property type="nucleotide sequence ID" value="XM_018181457.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CHU6"/>
    <dbReference type="STRING" id="1460663.A0A177CHU6"/>
    <dbReference type="GeneID" id="28764943"/>
    <dbReference type="InParanoid" id="A0A177CHU6"/>
    <dbReference type="OrthoDB" id="417891at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43180">
        <property type="entry name" value="3-OXOACYL-(ACYL-CARRIER-PROTEIN) REDUCTASE (AFU_ORTHOLOGUE AFUA_6G11210)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43180:SF66">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG06347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="283" mass="30736" checksum="AB4B85D235B024CB" modified="2016-09-07" version="1">MASPFQLPNGKPKTVIVTGGAGGIGAQTVRAFHEKGCNVVIADLPFSRDAAHELISSLSNSSRAMYFPSNIADWENMRALFRESKKMYGQVDIVIANAGMMESSNFFDFEEDEGGELVESRDSQRVIDVNLKGTLNSSIILIASTSGYFGGTGVVSYISTKHAVVGAARASQRKAKELNIRVNVLAPFFTPTYITGRYSDEWKKRGLPANTVEDVANAVISTSTDPARKGHHVMVAGSFIKEIEIARTALTKQWLGEDIADVMAKGGQFFDDMGGYPMPKPRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CI53</accession>
    <name>A0A177CI53_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_1187385</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG06510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036875.1">
        <property type="nucleotide sequence ID" value="XM_018180926.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CI53"/>
    <dbReference type="STRING" id="1460663.A0A177CI53"/>
    <dbReference type="GeneID" id="28764412"/>
    <dbReference type="InParanoid" id="A0A177CI53"/>
    <dbReference type="OrthoDB" id="3358371at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051164">
        <property type="entry name" value="NmrA-like_oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748">
        <property type="entry name" value="NITROGEN METABOLITE REPRESSION PROTEIN NMRA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748:SF26">
        <property type="entry name" value="NMRA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="3"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAG06510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="335" mass="36728" checksum="1D06056A9D5A4FFD" modified="2016-09-07" version="1">MSKKLIVVVGATGNQGGSVARRFLAAGYRVRGLTRTTASSAATALASAGVEMVQADLDDVQSLKEAFRGANAIFSVTNYWEPFFSGRAEAQEMDISCREYAYDIEFLQGKNIADAAAATVDTLDENGFFASTLSHADKCSDGKFEELYHFDAKADIFPGYVNKKYPSLAAKMSCIHTGYFFTSYNILPDSYFKKNPDGTFTMAFTTIPVKPVPHFDPVGDMGVFTYAVSQMPPGKAYMAAGTTCTWPEFLETWAKINGVKANYKQVSPEEMIESTEDRETGIEVAAMYSYASDPGYDGGMNLLTAIDLQKAGIDCPMTTWEDWAKKHDWSSVLNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CIR9</accession>
    <name>A0A177CIR9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CC84DRAFT_1163574</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG07403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037768.1">
        <property type="nucleotide sequence ID" value="XM_018178296.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CIR9"/>
    <dbReference type="STRING" id="1460663.A0A177CIR9"/>
    <dbReference type="GeneID" id="28761782"/>
    <dbReference type="InParanoid" id="A0A177CIR9"/>
    <dbReference type="OrthoDB" id="415706at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048312">
        <property type="term" value="P:intracellular distribution of mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000266">
        <property type="term" value="P:mitochondrial fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016559">
        <property type="term" value="P:peroxisome fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08771">
        <property type="entry name" value="DLP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022812">
        <property type="entry name" value="Dynamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001401">
        <property type="entry name" value="Dynamin_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000375">
        <property type="entry name" value="Dynamin_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030381">
        <property type="entry name" value="G_DYNAMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020850">
        <property type="entry name" value="GED_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566">
        <property type="entry name" value="DYNAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566:SF149">
        <property type="entry name" value="GTPASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G11890)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01031">
        <property type="entry name" value="Dynamin_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00195">
        <property type="entry name" value="DYNAMIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00053">
        <property type="entry name" value="DYNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51718">
        <property type="entry name" value="G_DYNAMIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51388">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynamin-type G" evidence="6">
        <location>
            <begin position="55"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="GED" evidence="5">
        <location>
            <begin position="656"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="708"/>
            <end position="735"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAG07403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="746" mass="84385" checksum="20AB5E889CADE1E2" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CJ60</accession>
    <name>A0A177CJ60_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fructose-bisphosphate aldolase</fullName>
            <shortName evidence="3">FBP aldolase</shortName>
            <ecNumber evidence="3">4.1.2.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_1163126</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>beta-D-fructose 1,6-bisphosphate = D-glyceraldehyde 3-phosphate + dihydroxyacetone phosphate</text>
            <dbReference type="Rhea" id="RHEA:14729"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="4.1.2.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="2 3">Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 4/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class II fructose-bisphosphate aldolase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.13" evidence="3"/>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG06827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037192.1">
        <property type="nucleotide sequence ID" value="XM_018178182.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CJ60"/>
    <dbReference type="STRING" id="1460663.A0A177CJ60"/>
    <dbReference type="GeneID" id="28761668"/>
    <dbReference type="InParanoid" id="A0A177CJ60"/>
    <dbReference type="OrthoDB" id="2558351at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00183"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004332">
        <property type="term" value="F:fructose-bisphosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00947">
        <property type="entry name" value="TBP_aldolase_IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050246">
        <property type="entry name" value="Class_II_FBP_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000771">
        <property type="entry name" value="FBA_II"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30304">
        <property type="entry name" value="D-TAGATOSE-1,6-BISPHOSPHATE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30304:SF0">
        <property type="entry name" value="D-TAGATOSE-1,6-BISPHOSPHATE ALDOLASE SUBUNIT GATY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01116">
        <property type="entry name" value="F_bP_aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001359">
        <property type="entry name" value="F_bP_aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0862">Zinc</keyword>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="85"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="217"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR001359-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR001359-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU366023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAG06827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="293" mass="31881" checksum="33C74FD534CDA91B" modified="2016-09-07" version="1">MAPDLSQNRCLKIVTHAAKNKYAVPAICCYNIESIIASVKAAEAKNSPVIVQLFPWAIHFAGGILVHAAKEAADNAKVPVGVHMDHAQTPEIVKKAADLGGFDGIMVDMSHYEKEENFRLTKELVQYCNERGIITEAEPGRIDGGEDGVGDVSALGLEAILTTPEQAEEFVSLGINWLAPAFGNVHGKYGPKGPQLDYDRLSRVHKQVGDRVDLVLHGAGTEWFSNKEMLQSVIQRGVAKINLNDAINNDFTRVMAEKASNTPLTTLLEDATNAMQKAVEDHMDYMGSTGQAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CJ84</accession>
    <name>A0A177CJ84_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ricin B lectin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1216347</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG07376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037741.1">
        <property type="nucleotide sequence ID" value="XM_018182792.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CJ84"/>
    <dbReference type="GeneID" id="28766278"/>
    <dbReference type="InParanoid" id="A0A177CJ84"/>
    <dbReference type="OrthoDB" id="4426724at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008058241" description="Ricin B lectin" evidence="1">
        <location>
            <begin position="20"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG07376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="178" mass="19573" checksum="A5AF359650B7B1FD" modified="2016-09-07" version="1">MKFSLLVTALVYASTGSCAAITYTIQRASNPTADQTDAYNKIDAAMKLAIARYGKYCNAKCTKKITVQYEPSVPTADANYNGNMRFGSNRSYMNERTAMHEISHTLGVGQTANFDSLCASGNWKTALPLLRSFDGSSAKISCGGSHFWPYGLNYDTEWSETNANRHVQMMQAMLNDGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CJC0</accession>
    <name>A0A177CJC0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DUF1741-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CC84DRAFT_1089200</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG07072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037437.1">
        <property type="nucleotide sequence ID" value="XM_018174292.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CJC0"/>
    <dbReference type="STRING" id="1460663.A0A177CJC0"/>
    <dbReference type="GeneID" id="28757778"/>
    <dbReference type="InParanoid" id="A0A177CJC0"/>
    <dbReference type="OrthoDB" id="2012278at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039868">
        <property type="entry name" value="ARMD3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013636">
        <property type="entry name" value="ARMH3_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13608">
        <property type="entry name" value="ARMADILLO-LIKE HELICAL DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13608:SF3">
        <property type="entry name" value="ARMADILLO-LIKE HELICAL DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08427">
        <property type="entry name" value="ARMH3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01158">
        <property type="entry name" value="DUF1741"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Armadillo-like helical" evidence="5">
        <location>
            <begin position="400"/>
            <end position="625"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAG07072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="628" mass="70454" checksum="DCA454EF3334C74E" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CJF6</accession>
    <name>A0A177CJF6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1216359</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG07391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037756.1">
        <property type="nucleotide sequence ID" value="XM_018182795.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CJF6"/>
    <dbReference type="STRING" id="1460663.A0A177CJF6"/>
    <dbReference type="GeneID" id="28766281"/>
    <dbReference type="InParanoid" id="A0A177CJF6"/>
    <dbReference type="OrthoDB" id="10252009at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040410">
        <property type="entry name" value="UPF0658_Golgi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34391">
        <property type="entry name" value="UPF0658 GOLGI APPARATUS MEMBRANE PROTEIN C1952.10C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34391:SF1">
        <property type="entry name" value="UPF0658 GOLGI APPARATUS MEMBRANE PROTEIN C1952.10C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="180"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="216"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="242"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="281"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG07391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="353" mass="40205" checksum="1D50491A6681CE24" modified="2016-09-07" version="1">MPSWVPRSKLEWAYFGSTATQAVAIIPAQVTILVVYLQWVNSVVYQVPLAYVTPLTLGTTALGALYQLALTLDAYRIKNNIQLFVQCVCNICLSIATVMQYSQIKEANRRILINHDMYGTPFAKHEWKFWDHVSPALITCIVVSCACSVAMCLFAYGLYREFSWALYEQVSPDRKMRLRYFAYQIYLVILKFTPFFIISFILLYDLIDVHYVEPEFSLTMAIIPVALIHVGLAVYFVRIETFIGMSFVLVGHVAEIVYLVSRIVVLNSRSRLANTLLKDEMVFMAVVALGFSAIAFTAGSICVTNFRKGLKPLVLGQVQRKRPNNDFENDYQFQRLNHNVVAAPEQARRFALD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CJS8</accession>
    <name>A0A177CJS8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Arsenical-resistance protein ACR3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CC84DRAFT_1118327</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cell membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the arsenical resistance-3 (ACR3) (TC 2.A.59) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG07753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038118.1">
        <property type="nucleotide sequence ID" value="XM_018175519.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CJS8"/>
    <dbReference type="FunCoup" id="A0A177CJS8">
        <property type="interactions" value="15"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CJS8"/>
    <dbReference type="GeneID" id="28759005"/>
    <dbReference type="InParanoid" id="A0A177CJS8"/>
    <dbReference type="OrthoDB" id="187348at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015104">
        <property type="term" value="F:antimonite transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015105">
        <property type="term" value="F:arsenite transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046685">
        <property type="term" value="P:response to arsenic-containing substance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1530.20:FF:000009">
        <property type="entry name" value="Arsenite transporter, ACR3 family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004706">
        <property type="entry name" value="Arsenical-R_Acr3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002657">
        <property type="entry name" value="BilAc:Na_symport/Acr3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00832">
        <property type="entry name" value="acr3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43057:SF1">
        <property type="entry name" value="ARSENICAL-RESISTANCE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43057">
        <property type="entry name" value="ARSENITE EFFLUX TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01758">
        <property type="entry name" value="SBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005508">
        <property type="entry name" value="Acr3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0059">Arsenical resistance</keyword>
    <keyword evidence="4 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="126"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="155"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="186"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="228"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="262"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="293"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="337"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="363"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR005508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OAG07753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="386" mass="42590" checksum="AC17819C32ED1609" modified="2016-09-07" version="1">MDITTRSASQTRPHDENPSPLDDAEKGSDTAQVNHVVEDEKILPPLRGLSFLDRFLVIWIILAMAIGIVLGNTVDSVGPALQKGEFVGVSIPIAIGLLVMMYPILCKVRFESLHLLLNSRALWIQIGISFVLNWIVAPLFMVGLAWAFLPDRQDLREGLIFVGIARCIAMVLIWTDLAKGDGDYCAVLVAFNSILQIVLFAPFAVFYVQVVSHGQKTDVSYEKVAQSVGVFLGIPLGAAVLTRLLLRGLIGEDRYQRRFIRYIAPFSLIGLLYTIIVLFASQGAHVVRQITDVLRVCAPLLVYFLVIFSSTVWFCWKMGFGYKISCTQSFTAASNNFELAIAVVVAVYGAGSGQALASTVGPLIEVPVLVALVYVLKWLRARWQWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CK56</accession>
    <name>A0A177CK56_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Chorismate synthase</fullName>
            <ecNumber evidence="4 8">4.2.3.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CC84DRAFT_703026</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>5-O-(1-carboxyvinyl)-3-phosphoshikimate = chorismate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:21020"/>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57701"/>
            <dbReference type="EC" id="4.2.3.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>FMNH2</name>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
        </cofactor>
        <text evidence="8">Reduced FMN (FMNH(2)).</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 7/7.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the chorismate synthase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.5" evidence="4 8"/>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG07631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037996.1">
        <property type="nucleotide sequence ID" value="XM_018187106.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CK56"/>
    <dbReference type="FunCoup" id="A0A177CK56">
        <property type="interactions" value="240"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CK56"/>
    <dbReference type="GeneID" id="28770592"/>
    <dbReference type="InParanoid" id="A0A177CK56"/>
    <dbReference type="OrthoDB" id="1721239at2759"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00090"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004107">
        <property type="term" value="F:chorismate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042602">
        <property type="term" value="F:riboflavin reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07304">
        <property type="entry name" value="Chorismate_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.150.10:FF:000004">
        <property type="entry name" value="Chorismate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.150.10">
        <property type="entry name" value="Chorismate synthase AroC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00300">
        <property type="entry name" value="Chorismate_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000453">
        <property type="entry name" value="Chorismate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035904">
        <property type="entry name" value="Chorismate_synth_AroC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020541">
        <property type="entry name" value="Chorismate_synthase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00033">
        <property type="entry name" value="aroC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003793">
        <property type="entry name" value="PRK05382.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21085">
        <property type="entry name" value="CHORISMATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21085:SF0">
        <property type="entry name" value="CHORISMATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01264">
        <property type="entry name" value="Chorismate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001456">
        <property type="entry name" value="Chorismate_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103263">
        <property type="entry name" value="Chorismate synthase, AroC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00787">
        <property type="entry name" value="CHORISMATE_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00788">
        <property type="entry name" value="CHORISMATE_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00789">
        <property type="entry name" value="CHORISMATE_SYNTHASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 8" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="7 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="292"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="303"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAG07631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="411" mass="44004" checksum="78A83B8ED61D46CB" modified="2016-09-07" version="1">MSTFGNHFKVTTYGESHCLSVGCIVDGCPPGMALTEADIQPQMTRRRPGQSAITTPRNEKDKVEIQSGTEFGITLGTPIGMKVMNENQRKQDYGNQTMDVYPRPSHADWTYLEKYGVKASSGGGRSSARETIGRVAAGAIAEKYLREAYGVEIVAFTNSIGNEFLFPPTPEHPTCATNPEYLKAIDVITREQVDQFLPVRCPNDEVNRRMEKLVADYKEKEDSIGGTVTCVIRNCPSGLGEPCFDKLEATLAHAMLSIPATKGFEIGSGFGGCQVPGSIHNDPFIKAPAVPAGTGHPSVQRPRLTTKTNNSGGVQGGISNGAPIYFTVAFKPPATIGQAQQTATYDTDEGVLEAKGRHDPCVVPRAVPIVESMAALVIMDAVLAQQSRAAARSLLPPLKGVVPVAETRNGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CK70</accession>
    <name>A0A177CK70_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1163406</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG07187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037552.1">
        <property type="nucleotide sequence ID" value="XM_018178257.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CK70"/>
    <dbReference type="STRING" id="1460663.A0A177CK70"/>
    <dbReference type="GeneID" id="28761743"/>
    <dbReference type="InParanoid" id="A0A177CK70"/>
    <dbReference type="OrthoDB" id="3993201at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG07187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="247" mass="26703" checksum="0EE444EE6F265B68" modified="2016-09-07" version="1">MQATRVSSRAFKAVAAGSRQSRSLHMTGPATFSNLLTSERPAMNHPQSLAGLRYECQVLKLPTTGSKEELQSRLSAHELTNGARTFSTAVDDSKRPLVGAPVTGRSFRHFNTSRELKSPNDSSTIDFAFIPDFDPDLGAAPVNIRVPILPTTITPNPSYTFASAIEAAEAEEEYSARLPRIHTVSSHHVHAPAAMSEVHDNNTIDFQGMAFEAVNKLKRPVEEGASMAKQIWGGLVDDVLGPKGKPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CK79</accession>
    <name>A0A177CK79_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Alpha-1,2-mannosidase family protein-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CC84DRAFT_642624</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG07197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037562.1">
        <property type="nucleotide sequence ID" value="XM_018186990.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CK79"/>
    <dbReference type="STRING" id="1460663.A0A177CK79"/>
    <dbReference type="GeneID" id="28770476"/>
    <dbReference type="InParanoid" id="A0A177CK79"/>
    <dbReference type="OrthoDB" id="449263at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000224">
        <property type="term" value="F:peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006516">
        <property type="term" value="P:glycoprotein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1610.10:FF:000002">
        <property type="entry name" value="Alpha-1,2-mannosidase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.98.10:FF:000010">
        <property type="entry name" value="Alpha-1,2-mannosidase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2080.10:FF:000001">
        <property type="entry name" value="Alpha-1,2-mannosidase subfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.60:FF:000002">
        <property type="entry name" value="Glycosyl hydrolase family 92"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.60">
        <property type="entry name" value="alpha-1,2-mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1610.10">
        <property type="entry name" value="alpha-1,2-mannosidases domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2080.10">
        <property type="entry name" value="GH92 mannosidase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005887">
        <property type="entry name" value="GH92_a_mannosidase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041371">
        <property type="entry name" value="GH92_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012939">
        <property type="entry name" value="Glyco_hydro_92"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050883">
        <property type="entry name" value="PNGase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01180">
        <property type="entry name" value="aman2_put"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12143">
        <property type="entry name" value="PEPTIDE N-GLYCANASE PNGASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12143:SF23">
        <property type="entry name" value="PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07971">
        <property type="entry name" value="Glyco_hydro_92"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17678">
        <property type="entry name" value="Glyco_hydro_92N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008058274" evidence="2">
        <location>
            <begin position="22"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 92 N-terminal" evidence="4">
        <location>
            <begin position="36"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 92" evidence="3">
        <location>
            <begin position="293"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="776"/>
            <end position="799"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAG07197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="799" mass="87982" checksum="371EB3772AED0065" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CKU4</accession>
    <name>A0A177CKU4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metallo-dependent phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1161972</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG07926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038291.1">
        <property type="nucleotide sequence ID" value="XM_018177872.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CKU4"/>
    <dbReference type="GeneID" id="28761358"/>
    <dbReference type="InParanoid" id="A0A177CKU4"/>
    <dbReference type="OrthoDB" id="630188at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07379">
        <property type="entry name" value="MPP_239FB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051693">
        <property type="entry name" value="UPF0046_metallophosphoest"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12905:SF18">
        <property type="entry name" value="ESTER HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G03130)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12905">
        <property type="entry name" value="METALLOPHOSPHOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="1">
        <location>
            <begin position="60"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG07926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="349" mass="39497" checksum="365266D3B14CFFA8" modified="2016-09-07" version="1">MVLNSLPWRRKTKAAQPDPFEPTPILRLAYQAPVKLLLYHAYHTITSLRSNPTPSQPPIRIVCMSDTHGHTIDSVPDGDILIHAGDMTVYGSIPEIQAQVDWLCSLPHKEIVVISGNHDTYLDPRTRPSLRDDQRAGAVDWKRVHYLQHRRLSLSIDVDPPGADGEETTHLLARETKSRRVRIYGAPQIPACGDVNVHAFQYPRGRDAWSETVPEDTDILVTHTPPKYHMDLALPSGMGCEHLAAEVRRVKPTLHVFGHVHWGAGHEVVWWEGCHDAYEKGMRIEPRWFKGLLNPGLWWNVFRVMYRGIRELIWDKVWGGQGPNTIMVNAAQMHGNTGKLGNPIQVVDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CKV1</accession>
    <name>A0A177CKV1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_556032</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038498.1">
        <property type="nucleotide sequence ID" value="XM_018186679.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CKV1"/>
    <dbReference type="STRING" id="1460663.A0A177CKV1"/>
    <dbReference type="GeneID" id="28770165"/>
    <dbReference type="InParanoid" id="A0A177CKV1"/>
    <dbReference type="OrthoDB" id="3357002at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021460">
        <property type="entry name" value="DUF3112"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35184:SF1">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35184">
        <property type="entry name" value="YALI0C10208P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11309">
        <property type="entry name" value="DUF3112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="140"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="181"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="216"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="260"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="375"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="429"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="381"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG08133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="606" mass="67667" checksum="69B10EDE55813284" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CLM8</accession>
    <name>A0A177CLM8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1144413</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG07687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038052.1">
        <property type="nucleotide sequence ID" value="XM_018176455.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CLM8"/>
    <dbReference type="GeneID" id="28759941"/>
    <dbReference type="InParanoid" id="A0A177CLM8"/>
    <dbReference type="OrthoDB" id="3777651at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG07687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="348" mass="38808" checksum="4EC398568DF3BD60" modified="2016-09-07" version="1">MAREGTALRAGRAAGAGVVKVNESKPPSSKRPVSAASIFKQQQSKAVKNSVVTPVLHTSAMKKWTQAKRGSSSSPEKMGSNDGRKQDDLHPLAAAFNDTARAYRQTLLESTTRKLDDTLSHLLDQLNDFNITTSSSPPQASDPNDSPQRLTIADRADRTAKKLFTPLGQYELTVARNDPNGEEYRVVQKLEDGLVDYQARHEHRIEEIRKLEVKWETVVGEIWKVGINCLGEDAMSALLLIKPAPPPSPPAKAERYSLMLADLDPRPVRKKVKFEESAPKLPRFLTSASRYADLPIPKQISKDDIKMLTEKVNDFGTEQIEALTKVKKDGEIWWEKKQAQMMIALQED</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CLQ1</accession>
    <name>A0A177CLQ1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CC84DRAFT_1087698</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG07872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038237.1">
        <property type="nucleotide sequence ID" value="XM_018174212.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CLQ1"/>
    <dbReference type="GeneID" id="28757698"/>
    <dbReference type="InParanoid" id="A0A177CLQ1"/>
    <dbReference type="OrthoDB" id="2105912at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17324">
        <property type="entry name" value="MFS_NepI_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42910:SF1">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42910">
        <property type="entry name" value="TRANSPORTER SCO4007-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="34"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="159"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="191"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="227"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="314"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="4">
        <location>
            <begin position="1"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="354"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="385"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAG07872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="421" mass="45535" checksum="B18C575C76066A6F" modified="2016-09-07" version="1">MQAGYAAGLLFLCPLGDLLPRRPFVVGLVGITATLWLGLCLTSNLGVFTAISFLVSITTVTPQLMLPLVGDLAPPHRRAAALSVVVSGLQLGILIARVLSGTISNFVTWRAVYWMAFGLQYLIFVLLWFFMPDYPATNTSLNYFRLLWSIVQMLTRHPVLVQACLAGFFTSSTFTSFWTTLTFLLAGAPYFYSPLVIGLFGLIGIAAMCFGPVYARKVTDKFVPHMTVLFGLFCCMLGICFGTYLGTFTVAGPVLQAFLLDFGMQTAQIANRSAIYAIEPTRRNGVNTAFMVATFCGQLMGTAAGSHIYAEAGWIGSGSASVGFIGAAILIMVARGPWETRWVGWGGGWSFKKKNQNSADGKTAETGNAIRGMEPSDEEMGAEVKALDEAAAEEEHQRPLKDESEKSKRSSGVDKIGLVNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CMM8</accession>
    <name>A0A177CMM8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_1162195</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038567.1">
        <property type="nucleotide sequence ID" value="XM_018177936.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CMM8"/>
    <dbReference type="FunCoup" id="A0A177CMM8">
        <property type="interactions" value="15"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CMM8"/>
    <dbReference type="GeneID" id="28761422"/>
    <dbReference type="InParanoid" id="A0A177CMM8"/>
    <dbReference type="OrthoDB" id="7722975at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019677">
        <property type="term" value="P:NAD+ catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd07407">
        <property type="entry name" value="MPP_YHR202W_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000043">
        <property type="entry name" value="Ser/Thr protein phosphatase family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.780.10:FF:000009">
        <property type="entry name" value="Ser/Thr protein phosphatase family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.780.10">
        <property type="entry name" value="5'-Nucleotidase, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036907">
        <property type="entry name" value="5'-Nucleotdase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006179">
        <property type="entry name" value="5_nucleotidase/apyrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053828">
        <property type="entry name" value="Nucleosidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014485">
        <property type="entry name" value="Pesterase_C1039"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041823">
        <property type="entry name" value="YHR202W_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11575">
        <property type="entry name" value="5'-NUCLEOTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11575:SF43">
        <property type="entry name" value="SER_THR PROTEIN PHOSPHATASE FAMILY (AFU_ORTHOLOGUE AFUA_3G04160)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21953">
        <property type="entry name" value="NadN_nucleosid_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017316">
        <property type="entry name" value="Pesterase_C1039"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55816">
        <property type="entry name" value="5'-nucleotidase (syn. UDP-sugar hydrolase), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008058477" evidence="1">
        <location>
            <begin position="18"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="2">
        <location>
            <begin position="39"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="Putative 5'-nucleotidase C-terminal" evidence="3">
        <location>
            <begin position="366"/>
            <end position="573"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF21953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAG08202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="617" mass="70068" checksum="16F635F6C8F5CF96" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CMW2</accession>
    <name>A0A177CMW2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">FAD/FMN-containing isoamyl alcohol oxidase-like protein MreA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_1257136</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038605.1">
        <property type="nucleotide sequence ID" value="XM_018184700.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CMW2"/>
    <dbReference type="STRING" id="1460663.A0A177CMW2"/>
    <dbReference type="GeneID" id="28768186"/>
    <dbReference type="InParanoid" id="A0A177CMW2"/>
    <dbReference type="OrthoDB" id="415825at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF39">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008058375" evidence="6">
        <location>
            <begin position="20"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="7">
        <location>
            <begin position="152"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAG08240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="650" mass="71595" checksum="318969484D1D2B92" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CN54</accession>
    <name>A0A177CN54_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ecp2 effector protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1173710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038542.1">
        <property type="nucleotide sequence ID" value="XM_018180052.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CN54"/>
    <dbReference type="GeneID" id="28763538"/>
    <dbReference type="InParanoid" id="A0A177CN54"/>
    <dbReference type="OrthoDB" id="10433774at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006771">
        <property type="entry name" value="CetA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04681">
        <property type="entry name" value="Bys1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008058410" description="Ecp2 effector protein domain-containing protein" evidence="1">
        <location>
            <begin position="28"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG08177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="194" mass="20080" checksum="752B37F55C1A58B8" modified="2016-09-07" version="1">MLLFTKPPCFLILCLSSLLLPIPPTSALPTSSFPTRTNTTTINAYVENNCVFPIHALQSWCNGAGGTAHISPHTAIWFGHESGRDECGVSIALTRGEEGEGEGVGEGGGPARLERRMYEVRYQVDSVGGIVYGLGASEADGFGGVAGMLEVEGSGCAPIVFTAGDGRDGDGSGGSEGAQAKSCDQAGDVRFYLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CNK3</accession>
    <name>A0A177CNK3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Alpha-glucosides permease MPH2/3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CC84DRAFT_1085259</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038927.1">
        <property type="nucleotide sequence ID" value="XM_018174094.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CNK3"/>
    <dbReference type="GeneID" id="28757580"/>
    <dbReference type="InParanoid" id="A0A177CNK3"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000078">
        <property type="entry name" value="MFS maltose transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF57">
        <property type="entry name" value="MALTOSE TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G00150)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="171"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="202"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="225"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="314"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="348"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="378"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="412"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="450"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="479"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="60"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAG08562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="532" mass="58872" checksum="818372AF331CB080" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CNP7</accession>
    <name>A0A177CNP7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CC84DRAFT_1162911</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG09143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039508.1">
        <property type="nucleotide sequence ID" value="XM_018178122.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CNP7"/>
    <dbReference type="STRING" id="1460663.A0A177CNP7"/>
    <dbReference type="GeneID" id="28761608"/>
    <dbReference type="InParanoid" id="A0A177CNP7"/>
    <dbReference type="OrthoDB" id="331544at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008460">
        <property type="term" value="F:dTDP-glucose 4,6-dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009225">
        <property type="term" value="P:nucleotide-sugar metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05246">
        <property type="entry name" value="dTDP_GD_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000304">
        <property type="entry name" value="UDP-glucose 4,6-dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005888">
        <property type="entry name" value="dTDP_Gluc_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43000">
        <property type="entry name" value="DTDP-D-GLUCOSE 4,6-DEHYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16363">
        <property type="entry name" value="GDP_Man_Dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-binding" evidence="4">
        <location>
            <begin position="58"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAG09143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="425" mass="47979" checksum="977BC3A758DF3AC1" modified="2016-09-07" version="1">MSAIESPDCAPVTNGLKNRRNSTVLNPRSYLTEDLWKQAPVLTGTTRFEPREDARNILVTGGAGFIACWFVRHLTLTYPDHYNVVSFDKLDYCATLNNTRILDGRSNFKFEQGDITSPADVKRVLRKHHIDTIFHFAAQSHVDLSFGNSYQFTNTNVYGTHVLLERAREHGISRFVHISTDEVYGDVPIGAADLSETSILAPTNPYSASKAAAEMMVSAYRKSFKLPLITVRSNNVYGPHQFPEKIIPKFIMLLQRRRKLLVHGDGSPTRRYLYAGDIVDALDTIFHKGDIGQIYNIATTDEISNTDICHRLLGLFGLAHETPADLEKSVQYTEDRPFNDQRYATDGSKLAALGWQPKTSFDDGLRRTVEWYRKFGEVWWGDISRVLTSFPVVEGMEIWTKEEHEALPSEDGALLDDDRVADGTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CQM7</accession>
    <name>A0A177CQM7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF1680-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_453829</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG09815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040180.1">
        <property type="nucleotide sequence ID" value="XM_018186335.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CQM7"/>
    <dbReference type="GeneID" id="28769821"/>
    <dbReference type="InParanoid" id="A0A177CQM7"/>
    <dbReference type="OrthoDB" id="5358475at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012878">
        <property type="entry name" value="Beta-AFase-like_GH127_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049046">
        <property type="entry name" value="Beta-AFase-like_GH127_middle"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31151">
        <property type="entry name" value="PROLINE-TRNA LIGASE (DUF1680)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31151:SF0">
        <property type="entry name" value="PROLINE-TRNA LIGASE (DUF1680)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07944">
        <property type="entry name" value="Beta-AFase-like_GH127_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20736">
        <property type="entry name" value="Glyco_hydro127M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008058475" evidence="1">
        <location>
            <begin position="25"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="domain" description="Non-reducing end beta-L-arabinofuranosidase-like GH127 catalytic" evidence="2">
        <location>
            <begin position="45"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="domain" description="Non-reducing end beta-L-arabinofuranosidase-like GH127 middle" evidence="3">
        <location>
            <begin position="502"/>
            <end position="594"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAG09815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="786" mass="86863" checksum="C506C9611EEE5630" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CQT0</accession>
    <name>A0A177CQT0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_1111592</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG09865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040230.1">
        <property type="nucleotide sequence ID" value="XM_018175287.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CQT0"/>
    <dbReference type="FunCoup" id="A0A177CQT0">
        <property type="interactions" value="16"/>
    </dbReference>
    <dbReference type="GeneID" id="28758773"/>
    <dbReference type="InParanoid" id="A0A177CQT0"/>
    <dbReference type="OrthoDB" id="413079at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000286">
        <property type="entry name" value="MFS efflux transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000308">
        <property type="entry name" value="MFS efflux transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051788">
        <property type="entry name" value="MFS_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23514">
        <property type="entry name" value="BYPASS OF STOP CODON PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23514:SF6">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="113"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="143"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="178"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="201"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="232"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="264"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="327"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="364"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="394"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="419"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="452"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="481"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="112"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="13"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="57"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="15"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="31"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="59"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAG09865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="509" mass="54295" checksum="92DEE0671E00EE1A" modified="2016-09-07" version="1">MASAALHGFFDIQQSSSTPSGSTPLVTSPPATHQKTTSTVKGAPFSIELDDLAFGQRYNGPSSPTTAPQTPKEFPGSQTPKTPNELEHDGAEGSGAVPLMQTWREPSMNKWRILCCCLIYFGNGINDSVVGALIPYMEEYYHIGYAIMSMVFVGNAAGFISAAFFCNTTLGKLGRAKTLILSEVILLAAYVILVATPPYAAVVVSFFLLGYGAATSLALNNVFCANLHPPSAILGAAHGSYGLGGIVAPIIGTALASRGILWSRFYFLCVGLRLCCMLFAGWAFWSYKEDQPQTLLSSLQRTATQQAASESQESKSKNLKLALKNRVTIFGALFVFAYQGAEVSISGWVISFLINYRDGDPARVGYVTSGFWGGITLGRFVLTHLAPRIGEKAFVTGLTIGTLCLQLLVWLVPNVIGDAVAVSLLGLLLGPVYPCAQTIFSRLMPRHVQTTAIGFIGGAGSSGGAVAPFTTGILAQAAGTWVLHPVCIGLYGAMIVFWWSLPRMSKRKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CRY3</accession>
    <name>A0A177CRY3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Histidine acid phosphatase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_1193315</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG09537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039902.1">
        <property type="nucleotide sequence ID" value="XM_018181286.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CRY3"/>
    <dbReference type="STRING" id="1460663.A0A177CRY3"/>
    <dbReference type="GeneID" id="28764772"/>
    <dbReference type="InParanoid" id="A0A177CRY3"/>
    <dbReference type="OrthoDB" id="6509975at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07061">
        <property type="entry name" value="HP_HAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1240:FF:000065">
        <property type="entry name" value="Similar to histidine acid phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016274">
        <property type="entry name" value="Histidine_acid_Pase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20963:SF12">
        <property type="entry name" value="HISTIDINE ACID PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20963">
        <property type="entry name" value="MULTIPLE INOSITOL POLYPHOSPHATE PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000894">
        <property type="entry name" value="Acid_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="100"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="284"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="450"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000894-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAG09537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="492" mass="55150" checksum="288F5AF754959967" modified="2016-09-07" version="1">MLLSWTFSKRGRLPVLATIAKKQLRPIFTSSHCGPNLAVAPRGWVKILDPFSGSQQAQVPIQPQDHSQGYQFDPLLHLPGISPYFDAVGFGLEHKAPDGCNVTAASYLVRHGAIYANDKEYEEFIKPFLWKLEKHREGWSGPLAFMSEWQSPVEEDKLEELTPSGAVDAAKVGKHLLERYEDLVPNTKRILADKKSRTYDTAKNLITAWAHNDTVEIVRVTKNKNGAMEELIPHKSCDAFSKEPGAEEQETFINMYGASVSTRLAPHMPFKLTPKDVVGLQQLCGYESAIKGKRSEICAVFTDAEWMAYEYAWDLRYAYMVGPMNPLSPYLGFPWLHAQSKIFQSIDENGKPGGSWPDEQRFFLSFTHREVPPFVATALGLFNSSSNSREQFPADHINWTRAWRMADLIPFLGHVGMEKMTCERGAVSGDGPGEFIRFIANTAPRPIPDCQTGPGASCPLGDFEHLIGKGAKKHKDFHKVCDKKDKKNGKHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CS04</accession>
    <name>A0A177CS04_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">GATA-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CC84DRAFT_1172114</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG09557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039922.1">
        <property type="nucleotide sequence ID" value="XM_018179956.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CS04"/>
    <dbReference type="STRING" id="1460663.A0A177CS04"/>
    <dbReference type="GeneID" id="28763442"/>
    <dbReference type="InParanoid" id="A0A177CS04"/>
    <dbReference type="OrthoDB" id="2162994at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00202">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47172:SF24">
        <property type="entry name" value="GATA ZINC FINGER DOMAIN-CONTAINING PROTEIN 14-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47172">
        <property type="entry name" value="OS01G0976800 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00320">
        <property type="entry name" value="GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00344">
        <property type="entry name" value="GATA_ZN_FINGER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GATA-type" evidence="8">
        <location>
            <begin position="452"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="416"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="489"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="20"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="52"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="70"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="99"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="124"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="177"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="228"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="255"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="494"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAG09557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="512" mass="55380" checksum="2D917FCDE31694F0" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CSR6</accession>
    <name>A0A177CSR6_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CC84DRAFT_457040</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG09930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040295.1">
        <property type="nucleotide sequence ID" value="XM_018186355.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CSR6"/>
    <dbReference type="FunCoup" id="A0A177CSR6">
        <property type="interactions" value="718"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CSR6"/>
    <dbReference type="GeneID" id="28769841"/>
    <dbReference type="InParanoid" id="A0A177CSR6"/>
    <dbReference type="OrthoDB" id="10253254at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005684">
        <property type="term" value="C:U2-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000390">
        <property type="term" value="P:spliceosomal complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21691">
        <property type="entry name" value="GH2-like_DHX8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05684">
        <property type="entry name" value="S1_DHX8_helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000061">
        <property type="entry name" value="ATP-dependent RNA helicase DHX8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1080:FF:000001">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000101">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000191">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049588">
        <property type="entry name" value="DHX8_GH2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049621">
        <property type="entry name" value="S1_DHX8_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF85">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DHX8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S1 motif" evidence="13">
        <location>
            <begin position="249"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="14">
        <location>
            <begin position="559"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="15">
        <location>
            <begin position="740"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="140"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1194"/>
            <end position="1213"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="463"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="173"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="196"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="216"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OAG09930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="1213" mass="135389" checksum="0E8C5935821C5D49" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CTT4</accession>
    <name>A0A177CTT4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1172751</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040687.1">
        <property type="nucleotide sequence ID" value="XM_018179996.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CTT4"/>
    <dbReference type="STRING" id="1460663.A0A177CTT4"/>
    <dbReference type="GeneID" id="28763482"/>
    <dbReference type="InParanoid" id="A0A177CTT4"/>
    <dbReference type="OrthoDB" id="5429993at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="259"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG10322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="550" mass="59793" checksum="7C7E4906224E8B9D" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CTZ2</accession>
    <name>A0A177CTZ2_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1139910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041359.1">
        <property type="nucleotide sequence ID" value="XM_018176266.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CTZ2"/>
    <dbReference type="GeneID" id="28759752"/>
    <dbReference type="InParanoid" id="A0A177CTZ2"/>
    <dbReference type="OrthoDB" id="4191831at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="21"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG10994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="587" mass="67085" checksum="01D16E3C338599D0" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CU63</accession>
    <name>A0A177CU63_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1213641</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040664.1">
        <property type="nucleotide sequence ID" value="XM_018182556.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CU63"/>
    <dbReference type="STRING" id="1460663.A0A177CU63"/>
    <dbReference type="GeneID" id="28766042"/>
    <dbReference type="InParanoid" id="A0A177CU63"/>
    <dbReference type="OrthoDB" id="4764735at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="323"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="323"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="364"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG10299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="433" mass="47591" checksum="0182E1C55B0547E8" modified="2016-09-07" version="1">MPKTFFGPRFVPTPRAPAPQLAALGSDWRSVRHRNIPLQRLRPVVSYPSDSTRASLWVAVPILTGGAVPPRSTHDGTSQDAAMPEITFIFGPNNSFFFDCPKTWKFHNIPLTLRQLFNSSMAPAWRIVQPFCLALAPPQTGSPEPVWYVGCKVLAGEEKILYSQTFFDTHYPSLSAWTKTIPNAPRSCYVTFGAGYSYFASAPGRGSVWAAIPSELSDKIQKAYDTPCCVALGVNEAWFVLWPDGYYSWKFYGAYAGLDGILSGAEPRSVTYLAISPYNPNHYFVAFRNRTVQYNFTGAPPEWMAQMNDVFAQWQAEIAQAQPGMPYAPPAQGQGQQPHFASPTPSGMLSPPSPITPLSQQPNVTSPSLSPQVPQVPHVPQVYAHYAPPPDPTAVEMPGSLPAGMMLEPPPPPAARPSSINVKRKKFFSKIFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CUY7</accession>
    <name>A0A177CUY7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Capsule polysaccharide biosynthesis protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1161671</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the lcsJ thioesterase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041193.1">
        <property type="nucleotide sequence ID" value="XM_018177802.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CUY7"/>
    <dbReference type="FunCoup" id="A0A177CUY7">
        <property type="interactions" value="30"/>
    </dbReference>
    <dbReference type="GeneID" id="28761288"/>
    <dbReference type="InParanoid" id="A0A177CUY7"/>
    <dbReference type="OrthoDB" id="265761at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00586">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051490">
        <property type="entry name" value="THEM6_lcsJ_thioesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12475">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12475:SF4">
        <property type="entry name" value="PROTEIN THEM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13279">
        <property type="entry name" value="4HBT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG10828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="363" mass="40461" checksum="898E8283208D27A4" modified="2016-09-07" version="1">MSRAISVAAVGAAVAALASQSSSRTFLARWSGVNTPGGVWRLLAVIFALMNFKNLPFVWHLRFFKAYWYQIFIQPTPIPPHALFQPVITQTHAPLLEIDFNMHKSNSTYFADMDISRTHLFTSIVRNAIRKVSEGGFHMPRASNKQASVSAATAGLGAAEGTNAPTGGNAKYMIALGGVQCNFKKEILPYQKFEMWTRLLSWDRKWFYLVTHLVRPGVGKPASFSLQPWRKSKRVQGEEVDPEKLKGAVFATAIARYVIKRGRLTIPPEKALFDADMVPEKPDGWVYAGEMEGEMNGKANGDAEGVLPEKGSVDWNWDVIERERRRGLRFAEAYSELDGLHEVWDGGKDGVLGEFGDLSLLNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CV85</accession>
    <name>A0A177CV85_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">GTP-binding protein ypt1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CC84DRAFT_1081848</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Preautophagosomal structure membrane</location>
            <topology evidence="8">Lipid-anchor</topology>
            <orientation evidence="8">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041145.1">
        <property type="nucleotide sequence ID" value="XM_018173950.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CV85"/>
    <dbReference type="FunCoup" id="A0A177CV85">
        <property type="interactions" value="1099"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CV85"/>
    <dbReference type="GeneID" id="28757436"/>
    <dbReference type="InParanoid" id="A0A177CV85"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01869">
        <property type="entry name" value="Rab1_Ypt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000069">
        <property type="entry name" value="Ras GTP-binding protein YPT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050227">
        <property type="entry name" value="Rab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057289">
        <property type="entry name" value="Rab1/Ypt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47977">
        <property type="entry name" value="RAS-RELATED PROTEIN RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0636">Prenylation</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="178"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="189"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00060489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00074496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OAG10780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="202" mass="22338" checksum="704A10C8D422D243" modified="2016-09-07" version="1" fragment="single">RLPPRYDYLFKLLLIGDSGVGKSCLLLRFADDTYTESYISTIGVDFKIRTIELDGKTVKLQIWDTAGQERFRTITSSYYRGAHGICVVYDVTDMDSFNNVKQWLQEIDRYATEGVNKLLVGNKSDMADKKVVEYTVAKEFADSLGIPFLETSAKSATNVEQAFLTMARQIKERMGTTTANTKPTVPIGQGQGVQSGSGGGCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CVG8</accession>
    <name>A0A177CVG8_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">Histone deacetylase</fullName>
            <ecNumber evidence="3 11">3.5.1.98</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CC84DRAFT_1081735</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>N(6)-acetyl-L-lysyl-[histone] + H2O = L-lysyl-[histone] + acetate</text>
            <dbReference type="Rhea" id="RHEA:58196"/>
            <dbReference type="Rhea" id="RHEA-COMP:9845"/>
            <dbReference type="Rhea" id="RHEA-COMP:11338"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="3.5.1.98"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the histone deacetylase family. HD type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.98" evidence="3 11"/>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG11018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041383.1">
        <property type="nucleotide sequence ID" value="XM_018173943.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CVG8"/>
    <dbReference type="FunCoup" id="A0A177CVG8">
        <property type="interactions" value="157"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CVG8"/>
    <dbReference type="ESTHER" id="9pleo-a0a177cvg8">
        <property type="family name" value="Arb2_domain"/>
    </dbReference>
    <dbReference type="GeneID" id="28757429"/>
    <dbReference type="InParanoid" id="A0A177CVG8"/>
    <dbReference type="OrthoDB" id="424012at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000791">
        <property type="term" value="C:euchromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070823">
        <property type="term" value="C:HDA1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990342">
        <property type="term" value="C:heterochromatin island"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031934">
        <property type="term" value="C:mating-type region heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005721">
        <property type="term" value="C:pericentric heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033553">
        <property type="term" value="C:rDNA heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070824">
        <property type="term" value="C:SHREC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140720">
        <property type="term" value="C:subtelomeric heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031078">
        <property type="term" value="F:histone H3K14 deacetylase activity, hydrolytic mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031508">
        <property type="term" value="P:pericentric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000183">
        <property type="term" value="P:rDNA heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030466">
        <property type="term" value="P:silent mating-type cassette heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902794">
        <property type="term" value="P:siRNA-independent facultative heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031509">
        <property type="term" value="P:subtelomeric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.800.20:FF:000005">
        <property type="entry name" value="histone deacetylase 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="entry name" value="Histone deacetylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019154">
        <property type="entry name" value="Arb2-like_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="HDACs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017321">
        <property type="entry name" value="Hist_deAcase_II_yeast"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625:SF5">
        <property type="entry name" value="HISTONE DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625">
        <property type="entry name" value="HISTONE DEACETYLASE HDAC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09757">
        <property type="entry name" value="Arb2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037919">
        <property type="entry name" value="HDAC_II_yeast"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0678">Repressor</keyword>
    <keyword evidence="8 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="7 11" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Histone deacetylase" evidence="13">
        <location>
            <begin position="56"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="Arb2-like" evidence="14">
        <location>
            <begin position="423"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="692"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="742"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="742"/>
            <end position="752"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR037919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF09757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OAG11018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="764" mass="85456" checksum="9F53C687DE9D4C17" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CVZ6</accession>
    <name>A0A177CVZ6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Ketoacyl-synt-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CC84DRAFT_1132787</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Secondary metabolite biosynthesis.</text>
    </comment>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG11208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041573.1">
        <property type="nucleotide sequence ID" value="XM_018175945.1"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CVZ6"/>
    <dbReference type="GeneID" id="28759431"/>
    <dbReference type="InParanoid" id="A0A177CVZ6"/>
    <dbReference type="OrthoDB" id="429813at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049492">
        <property type="entry name" value="BD-FAE-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041068">
        <property type="entry name" value="HTH_51"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013217">
        <property type="entry name" value="Methyltransf_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049551">
        <property type="entry name" value="PKS_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054514">
        <property type="entry name" value="RhiE-like_linker"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032088">
        <property type="entry name" value="SAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF21">
        <property type="entry name" value="NON-REDUCING POLYKETIDE SYNTHASE AUSA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20434">
        <property type="entry name" value="BD-FAE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18558">
        <property type="entry name" value="HTH_51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08242">
        <property type="entry name" value="Methyltransf_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22336">
        <property type="entry name" value="RhiE-like_linker"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16073">
        <property type="entry name" value="SAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="KS3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="2" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="11">
        <location>
            <begin position="343"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="12">
        <location>
            <begin position="1179"/>
            <end position="1488"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="10">
        <location>
            <begin position="1555"/>
            <end position="1629"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="8">
        <location>
            <begin position="1179"/>
            <end position="1308"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="8">
        <location>
            <begin position="1335"/>
            <end position="1488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1523"/>
            <end position="1556"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for dehydratase activity" evidence="8">
        <location>
            <position position="1216"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for dehydratase activity" evidence="8">
        <location>
            <position position="1397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OAG11208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="2378" mass="260130" checksum="21EF23CF3FA4772B" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CWD9</accession>
    <name>A0A177CWD9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Alcohol oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CC84DRAFT_1253721</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG11212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041577.1">
        <property type="nucleotide sequence ID" value="XM_018184394.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CWD9"/>
    <dbReference type="STRING" id="1460663.A0A177CWD9"/>
    <dbReference type="GeneID" id="28767880"/>
    <dbReference type="InParanoid" id="A0A177CWD9"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF138">
        <property type="entry name" value="DEHYDROGENASE PKFF-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008058669" evidence="4">
        <location>
            <begin position="27"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="5">
        <location>
            <begin position="40"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase C-terminal" evidence="6">
        <location>
            <begin position="462"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="579"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="591"/>
            <end position="592"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAG11212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="610" mass="65433" checksum="B2D909EC5C82C837" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CWZ2</accession>
    <name>A0A177CWZ2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1134381</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042449.1">
        <property type="nucleotide sequence ID" value="XM_018176021.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CWZ2"/>
    <dbReference type="STRING" id="1460663.A0A177CWZ2"/>
    <dbReference type="GeneID" id="28759507"/>
    <dbReference type="InParanoid" id="A0A177CWZ2"/>
    <dbReference type="OrthoDB" id="3344043at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="65"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="126"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="217"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="595"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG12084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="691" mass="76522" checksum="0BA53022B23513E4" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CXQ1</accession>
    <name>A0A177CXQ1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1170809</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG11996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042361.1">
        <property type="nucleotide sequence ID" value="XM_018179874.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CXQ1"/>
    <dbReference type="STRING" id="1460663.A0A177CXQ1"/>
    <dbReference type="GeneID" id="28763360"/>
    <dbReference type="InParanoid" id="A0A177CXQ1"/>
    <dbReference type="OrthoDB" id="5369729at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="461"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="589"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="797"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="45"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="156"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="228"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="255"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="302"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="406"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="461"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="589"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="620"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="639"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="732"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="744"/>
            <end position="757"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG11996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="823" mass="88631" checksum="4D278BE991A875CA" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CYA9</accession>
    <name>A0A177CYA9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Feruloyl esterase C</fullName>
            <ecNumber evidence="11">3.1.1.73</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Ferulic acid esterase C</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CC84DRAFT_1224985</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 11">Involved in degradation of plant cell walls. Hydrolyzes the feruloyl-arabinose ester bond in arabinoxylans, and the feruloyl-galactose ester bond in pectin. Active against paranitrophenyl-acetate, methyl ferulate and wheat arabinoxylan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>feruloyl-polysaccharide + H2O = ferulate + polysaccharide.</text>
            <dbReference type="EC" id="3.1.1.73"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the faeC family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.73" evidence="11"/>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG11689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042054.1">
        <property type="nucleotide sequence ID" value="XM_018183560.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CYA9"/>
    <dbReference type="STRING" id="1460663.A0A177CYA9"/>
    <dbReference type="ESTHER" id="9pleo-a0a177cya9">
        <property type="family name" value="FaeC"/>
    </dbReference>
    <dbReference type="GeneID" id="28767046"/>
    <dbReference type="InParanoid" id="A0A177CYA9"/>
    <dbReference type="OrthoDB" id="424610at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030600">
        <property type="term" value="F:feruloyl esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043595">
        <property type="entry name" value="FaeB/C/D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003140">
        <property type="entry name" value="PLipase/COase/thioEstase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38050:SF1">
        <property type="entry name" value="FERULOYL ESTERASE C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02230">
        <property type="entry name" value="Abhydrolase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6 11 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 11" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 11" id="KW-0732">Signal</keyword>
    <keyword evidence="4 11" id="KW-0858">Xylan degradation</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027140761" description="Feruloyl esterase C" evidence="11">
        <location>
            <begin position="24"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipase/carboxylesterase/thioesterase" evidence="12">
        <location>
            <begin position="119"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00034075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OAG11689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="281" mass="30394" checksum="8B1C222164274B93" modified="2016-09-07" version="1">MLVPVSFFALGALFLHLLDGVHAGTAGCGKSPTLTSGTKTVTVNGKQRRWILRIPEGYNSSQPYRLIFGLHWRDADMTGVDGGSAPYYGLKALAKNSAIFVAPDGLNKGWANQGGEDITFIDTIRQQIEDGLCVNENLRFSLGFSYGGAMSYSLACSRAKDFRAIAVLSGALLSGCSGGNDPIAFYGQHGVRDSVLPISMGRDIRDRFVKNNGCQTMQAKEPGKNSRQHIVNVYQNCNSSYPTQWTAFDADHVALPGDNGGDAGVNSFTISDVWKFFSQFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CYJ5</accession>
    <name>A0A177CYJ5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CC84DRAFT_1159303</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG11890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042255.1">
        <property type="nucleotide sequence ID" value="XM_018177191.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CYJ5"/>
    <dbReference type="STRING" id="1460663.A0A177CYJ5"/>
    <dbReference type="GeneID" id="28760677"/>
    <dbReference type="InParanoid" id="A0A177CYJ5"/>
    <dbReference type="OrthoDB" id="5569911at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056703">
        <property type="entry name" value="DUF7801"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029191">
        <property type="entry name" value="Uds1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47357">
        <property type="entry name" value="COP1-INTERACTIVE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47357:SF1">
        <property type="entry name" value="SPINDLE POLE BODY COMPONENT 110"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25078">
        <property type="entry name" value="DUF7801"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15456">
        <property type="entry name" value="Uds1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Up-regulated during septation protein 1" evidence="3">
        <location>
            <begin position="100"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7801" evidence="4">
        <location>
            <begin position="744"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="152"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="229"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="330"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="480"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="942"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="557"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="172"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="182"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="330"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="489"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="942"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="960"/>
            <end position="969"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF15456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAG11890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="976" mass="109379" checksum="BF87E5C95AC7C46E" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CYM1</accession>
    <name>A0A177CYM1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_154055</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018043009.1">
        <property type="nucleotide sequence ID" value="XM_018185388.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CYM1"/>
    <dbReference type="STRING" id="1460663.A0A177CYM1"/>
    <dbReference type="GeneID" id="28768874"/>
    <dbReference type="InParanoid" id="A0A177CYM1"/>
    <dbReference type="OrthoDB" id="3799540at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG12644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="91" mass="10232" checksum="0848E35CE05E86C1" modified="2016-09-07" version="1">MKSVDGGIIATRSRTFNTAFKTIKNVSAAKSFDTDQFPTELLVTEDYSRNVKRSARLPSKFFVSDSFHKPVQWILSVVQAGPPTERRPKQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CYR0</accession>
    <name>A0A177CYR0_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphoenolpyruvate carboxykinase (ATP)</fullName>
            <ecNumber evidence="3">4.1.1.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CC84DRAFT_1077854</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>oxaloacetate + ATP = phosphoenolpyruvate + ADP + CO2</text>
            <dbReference type="Rhea" id="RHEA:18617"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="4.1.1.49"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the phosphoenolpyruvate carboxykinase (ATP) family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.49" evidence="3"/>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042533.1">
        <property type="nucleotide sequence ID" value="XM_018173776.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CYR0"/>
    <dbReference type="FunCoup" id="A0A177CYR0">
        <property type="interactions" value="250"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CYR0"/>
    <dbReference type="GeneID" id="28757262"/>
    <dbReference type="InParanoid" id="A0A177CYR0"/>
    <dbReference type="OrthoDB" id="184182at2759"/>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004612">
        <property type="term" value="F:phosphoenolpyruvate carboxykinase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00484">
        <property type="entry name" value="PEPCK_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.8.10:FF:000001">
        <property type="entry name" value="Phosphoenolpyruvate carboxykinase (ATP)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.449.10:FF:000002">
        <property type="entry name" value="Phosphoenolpyruvate carboxykinase [ATP]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.228.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.449.10">
        <property type="entry name" value="Phosphoenolpyruvate Carboxykinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.8.10">
        <property type="entry name" value="Phosphoenolpyruvate Carboxykinase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00453">
        <property type="entry name" value="PEPCK_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001272">
        <property type="entry name" value="PEP_carboxykinase_ATP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013035">
        <property type="entry name" value="PEP_carboxykinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008210">
        <property type="entry name" value="PEP_carboxykinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015994">
        <property type="entry name" value="PEPCK_ATP_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00224">
        <property type="entry name" value="pckA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006820">
        <property type="entry name" value="PRK09344.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006821">
        <property type="entry name" value="PRK09344.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30031:SF0">
        <property type="entry name" value="PHOSPHOENOLPYRUVATE CARBOXYKINASE (ATP)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30031">
        <property type="entry name" value="PHOSPHOENOLPYRUVATE CARBOXYKINASE ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01293">
        <property type="entry name" value="PEPCK_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006294">
        <property type="entry name" value="PEP_crbxkin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68923">
        <property type="entry name" value="PEP carboxykinase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53795">
        <property type="entry name" value="PEP carboxykinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00532">
        <property type="entry name" value="PEPCK_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="5" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="12" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OAG12168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="561" mass="62163" checksum="BAF04E68B0AFEBFE" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CYX9</accession>
    <name>A0A177CYX9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1171384</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018043078.1">
        <property type="nucleotide sequence ID" value="XM_018179910.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CYX9"/>
    <dbReference type="GeneID" id="28763396"/>
    <dbReference type="InParanoid" id="A0A177CYX9"/>
    <dbReference type="OrthoDB" id="10453908at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="25"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG12713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="215" mass="24615" checksum="F6F806D9B420F2FC" modified="2016-09-07" version="1">MFASETAVWELGEHREWVRRDYQAEERLGLDKEEYDRETQRLKQEYEEWETECKRMEMEKAAGEVDRAWEKEVMEFQDDVDALEFAFLGKQDRRRKNGARGRKRPSKQSRVRVYHGAAKGVCKCIRAYDSSANTPTMSSYSTNDAYLFVGCGYTIVVAKAWGCMSQPNDQSFLLLENTSAVCPTACFSAYLSVPSTFACIVTTIGVSSVERTLKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CZ22</accession>
    <name>A0A177CZ22_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Probable glucan endo-1,3-beta-glucosidase eglC</fullName>
            <ecNumber evidence="5">3.2.1.39</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="20">Endo-1,3-beta-glucanase eglC</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="21">Laminarinase eglC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">CC84DRAFT_114656</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24 25">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="19">Glucanases play a role in cell expansion during growth, in cell-cell fusion during mating, and in spore release during sporulation. This enzyme may be involved in beta-glucan degradation and also function biosynthetically as a transglycosylase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of (1-&gt;3)-beta-D-glucosidic linkages in (1-&gt;3)-beta-D-glucans.</text>
            <dbReference type="EC" id="3.2.1.39"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
            <location evidence="2">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 22">Belongs to the glycosyl hydrolase 17 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.39" evidence="5"/>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042756.1">
        <property type="nucleotide sequence ID" value="XM_018176560.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CZ22"/>
    <dbReference type="STRING" id="1460663.A0A177CZ22"/>
    <dbReference type="GeneID" id="28760046"/>
    <dbReference type="InParanoid" id="A0A177CZ22"/>
    <dbReference type="OrthoDB" id="77201at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042973">
        <property type="term" value="F:glucan endo-1,3-beta-D-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050732">
        <property type="entry name" value="Beta-glucan_modifiers"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000490">
        <property type="entry name" value="Glyco_hydro_17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16631">
        <property type="entry name" value="GLUCAN 1,3-BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16631:SF13">
        <property type="entry name" value="GLUCAN ENDO-1,3-BETA-GLUCOSIDASE EGLC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00332">
        <property type="entry name" value="Glyco_hydro_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0134">Cell wall</keyword>
    <keyword evidence="17" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="16" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0964">Secreted</keyword>
    <keyword evidence="11 23" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="23">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008058780" description="Probable glucan endo-1,3-beta-glucosidase eglC" evidence="23">
        <location>
            <begin position="20"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00019762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00025152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00032134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00032906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="RuleBase" id="RU004335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="OAG12391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="313" mass="33008" checksum="0D38F45C3FEBEBE2" modified="2016-09-07" version="1">MQFFTSALAVAATFSVADAAIKGFNSGSTFSTGANKQQADFAYEMKAAQQLPGTNGAWTSVRLYTMIQGGTTDSPISAIPAAIETKSTLLLGLWASETSDAFQNELNALKNAISQYGTAFTDLVTGISVGSEDLYRTSTGEVGATPEQVVDFISKTRAVIKGTSLEGKPVGHVDTWDAFVNGANSAVVSACDFLGMDAYPYYQASTVGGNGIGNANATFWKAYTDTVGAAQGKPVWITETGWPIVGDTIGEAVPGAEDARTFWEEAVCHALATDVNMYYFQLQTSQGVQVNPDWGIKGAGDIVNEAVRFQVTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CZ29</accession>
    <name>A0A177CZ29_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Conidiation-specific protein 13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1212293</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018043160.1">
        <property type="nucleotide sequence ID" value="XM_018182441.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CZ29"/>
    <dbReference type="STRING" id="1460663.A0A177CZ29"/>
    <dbReference type="GeneID" id="28765927"/>
    <dbReference type="InParanoid" id="A0A177CZ29"/>
    <dbReference type="OrthoDB" id="2142213at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008058777" description="Conidiation-specific protein 13" evidence="2">
        <location>
            <begin position="20"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="272"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG12795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="322" mass="35664" checksum="34BB356FE50DE980" modified="2016-09-07" version="1">MGFLNTFASTLAAAAFVSAQHDAGAKLDKPTLHDNLDYLKQGIIDNLPETNFNYELQAAGTIPDDCNKVATGQVYNTVNYNPADFDIFNVHYDDCGDPWVFCHHKQSPITIDSMARQFGKLPVQMRQWIRHVVDVPSDGGWAFEFDGTVTFLDPKDDMMPVIVHETGHSLDLSGAYADKPMSSSDRWWDNYNQDSNVPDTYASTNAIEDVAQNTVVAVFNENYPGGFGAIEPDYEKISHQYYTLISEAIDAGQGNNLFKPGQSAQCTHRMAPTDPVPVGGSKKRSMRERRGAAPVVGLSKNVTEIVTKRDGAKKRSDCSLRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CZQ4</accession>
    <name>A0A177CZQ4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_1182902</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042514.1">
        <property type="nucleotide sequence ID" value="XM_018180652.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CZQ4"/>
    <dbReference type="STRING" id="1460663.A0A177CZQ4"/>
    <dbReference type="GeneID" id="28764138"/>
    <dbReference type="InParanoid" id="A0A177CZQ4"/>
    <dbReference type="OrthoDB" id="5215911at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF149">
        <property type="entry name" value="TRANSPORTER, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="193"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="222"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="346"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="389"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="432"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="459"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="492"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="524"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="67"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="284"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="286"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAG12149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="564" mass="62514" checksum="E3C77B94C8BD2541" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177D126</accession>
    <name>A0A177D126_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Pre-mRNA-processing factor 31</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CC84DRAFT_1110172</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PRP31 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG13108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018043473.1">
        <property type="nucleotide sequence ID" value="XM_018175242.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177D126"/>
    <dbReference type="FunCoup" id="A0A177D126">
        <property type="interactions" value="1154"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177D126"/>
    <dbReference type="GeneID" id="28758728"/>
    <dbReference type="InParanoid" id="A0A177D126"/>
    <dbReference type="OrthoDB" id="4771285at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005687">
        <property type="term" value="C:U4 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000244">
        <property type="term" value="P:spliceosomal tri-snRNP complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.246.90:FF:000002">
        <property type="entry name" value="U4/U6 small nuclear ribonucleoprotein Prp31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.4070:FF:000003">
        <property type="entry name" value="U4/U6 small nuclear ribonucleoprotein PRP31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.4070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.90">
        <property type="entry name" value="Nop domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042239">
        <property type="entry name" value="Nop_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002687">
        <property type="entry name" value="Nop_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036070">
        <property type="entry name" value="Nop_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012976">
        <property type="entry name" value="NOSIC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027105">
        <property type="entry name" value="Prp31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019175">
        <property type="entry name" value="Prp31_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13904">
        <property type="entry name" value="PRE-MRNA SPLICING FACTOR PRP31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13904:SF0">
        <property type="entry name" value="U4_U6 SMALL NUCLEAR RIBONUCLEOPROTEIN PRP31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01798">
        <property type="entry name" value="Nop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09785">
        <property type="entry name" value="Prp31_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00931">
        <property type="entry name" value="NOSIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89124">
        <property type="entry name" value="Nop domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51358">
        <property type="entry name" value="NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Nop" evidence="10">
        <location>
            <begin position="247"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="13"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="361"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="45"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="383"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OAG13108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="571" mass="61517" checksum="34FD513AD621F3FD" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BU70</accession>
    <name>A0A177BU70_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Zinc finger transcription factor ace1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_411357</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441563">
        <property type="protein sequence ID" value="OAF98962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029328.1">
        <property type="nucleotide sequence ID" value="XM_018186104.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BU70"/>
    <dbReference type="STRING" id="1460663.A0A177BU70"/>
    <dbReference type="GeneID" id="28769590"/>
    <dbReference type="InParanoid" id="A0A177BU70"/>
    <dbReference type="OrthoDB" id="9368434at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="397"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="124"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="486"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="124"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="154"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAF98962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="738" mass="81999" checksum="6AB694F6DAEFB51B" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BU72</accession>
    <name>A0A177BU72_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1169939</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441564">
        <property type="protein sequence ID" value="OAF98804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029170.1">
        <property type="nucleotide sequence ID" value="XM_018179794.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BU72"/>
    <dbReference type="GeneID" id="28763280"/>
    <dbReference type="InParanoid" id="A0A177BU72"/>
    <dbReference type="OrthoDB" id="10607988at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="8"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAF98804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="108" mass="11475" checksum="37E9B0FFA045062B" modified="2016-09-07" version="1" fragment="single">MDRFLTRSQASQASQSTQSTQVASSSSGSYHYAGSRTAAVMAMTDSFGSVDDSLSDADTAEVSADPHVWPGDLRANRAQFPIQHAAAVAGSLGSISHNLWQEEELQRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BUH0</accession>
    <name>A0A177BUH0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Putative laccase TilA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CC84DRAFT_1210711</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the multicopper oxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441565">
        <property type="protein sequence ID" value="OAF98620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018028986.1">
        <property type="nucleotide sequence ID" value="XM_018182309.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BUH0"/>
    <dbReference type="SMR" id="A0A177BUH0"/>
    <dbReference type="STRING" id="1460663.A0A177BUH0"/>
    <dbReference type="GeneID" id="28765795"/>
    <dbReference type="InParanoid" id="A0A177BUH0"/>
    <dbReference type="OrthoDB" id="2121828at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13850">
        <property type="entry name" value="CuRO_1_Abr2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13876">
        <property type="entry name" value="CuRO_2_Abr2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13898">
        <property type="entry name" value="CuRO_3_Abr2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000036">
        <property type="entry name" value="L-ascorbate oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033138">
        <property type="entry name" value="Cu_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002355">
        <property type="entry name" value="Cu_oxidase_Cu_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF488">
        <property type="entry name" value="LACCASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00079">
        <property type="entry name" value="MULTICOPPER_OXIDASE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00080">
        <property type="entry name" value="MULTICOPPER_OXIDASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0186">Copper</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008057335" evidence="7">
        <location>
            <begin position="19"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="10">
        <location>
            <begin position="26"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="8">
        <location>
            <begin position="165"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="9">
        <location>
            <begin position="465"/>
            <end position="583"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OAF98620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="597" mass="65467" checksum="785EE90126CE630C" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BVL5</accession>
    <name>A0A177BVL5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1223450</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441564">
        <property type="protein sequence ID" value="OAF98698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029064.1">
        <property type="nucleotide sequence ID" value="XM_018183492.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BVL5"/>
    <dbReference type="STRING" id="1460663.A0A177BVL5"/>
    <dbReference type="GeneID" id="28766978"/>
    <dbReference type="InParanoid" id="A0A177BVL5"/>
    <dbReference type="OrthoDB" id="3920693at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008057441" evidence="2">
        <location>
            <begin position="21"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAF98698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="84" mass="8827" checksum="C7F565A1D4FB1886" modified="2016-09-07" version="1">MKFTTVIVAVIFGTAVYGAALPDPNCRFPGMPCSRDAEANAGWGSGFKRLPGQPIGKREAEAEAEPVADPDADPNCRFPGMPCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BW94</accession>
    <name>A0A177BW94_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Dimethylallyl tryptophan synthase GliD1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_1105984</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the tryptophan dimethylallyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441566">
        <property type="protein sequence ID" value="OAF98599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018028965.1">
        <property type="nucleotide sequence ID" value="XM_018175119.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BW94"/>
    <dbReference type="STRING" id="1460663.A0A177BW94"/>
    <dbReference type="GeneID" id="28758605"/>
    <dbReference type="InParanoid" id="A0A177BW94"/>
    <dbReference type="OrthoDB" id="3354387at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004659">
        <property type="term" value="F:prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009820">
        <property type="term" value="P:alkaloid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13929">
        <property type="entry name" value="PT-DMATS_CymD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033964">
        <property type="entry name" value="ABBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012148">
        <property type="entry name" value="ABBA_DMATS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017795">
        <property type="entry name" value="ABBA_NscD-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03429">
        <property type="entry name" value="arom_pren_DMATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40627">
        <property type="entry name" value="INDOLE PRENYLTRANSFERASE TDIB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40627:SF4">
        <property type="entry name" value="PRENYLTRANSFERASE ASQH1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11991">
        <property type="entry name" value="Trp_DMAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000509">
        <property type="entry name" value="Trp_DMAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00036">
        <property type="entry name" value="Aromatic_Prenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01162">
        <property type="entry name" value="I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="3">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>L-tryptophan</name>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>dimethylallyl diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>dimethylallyl diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>dimethylallyl diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="271"/>
        </location>
        <ligand>
            <name>dimethylallyl diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="273"/>
        </location>
        <ligand>
            <name>dimethylallyl diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="275"/>
        </location>
        <ligand>
            <name>dimethylallyl diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="367"/>
        </location>
        <ligand>
            <name>dimethylallyl diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000509-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAF98599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="455" mass="51770" checksum="D987CFCA94E34122" modified="2016-09-07" version="1">MANNTSQNANGIAKAKAAKSSASSNTKSWQSLSLLLPQRNPDYDFWWGLTGPHLATMLENAGYSSEKQFEMLLFHFHWSVTYLGPRPRQGVDPNWKSLLEPDGSPIEYSWKWNAASSEPDVRFTMEPINEFSGTALDPLNQQPSLELLHRLAERLPSVDLTWVHHFYTSCFDHDKAKYVQEKASGVPIVTTTCLAFEFVRHGLSLKSYFLPRKLGQQGLLPLSEWEKTIRQLDPKNKALDMLLDFLSTSAEGKKMNPLNLAVDDVHPSQSRMKFYFQTPSTSFSSVRDVMTMDGRTTGLEKQLAELKDLIHAVTSLPADFPENLDVPVEEQYHPRVNGTIGEVPGQSGYLYYFDIRPGAKVPEIKFYTPVSRYGRDDHTLAKELTGWMKSRGRDAYCEGYLRMLENIAEHRRLDDGKGLQTYVSCMFKENDVLDITSYISPQVFHPSRLAQWGQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BWE5</accession>
    <name>A0A177BWE5_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SprT-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1156792</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441561">
        <property type="protein sequence ID" value="OAF99732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030098.1">
        <property type="nucleotide sequence ID" value="XM_018176985.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BWE5"/>
    <dbReference type="STRING" id="1460663.A0A177BWE5"/>
    <dbReference type="GeneID" id="28760471"/>
    <dbReference type="InParanoid" id="A0A177BWE5"/>
    <dbReference type="OrthoDB" id="20772at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006640">
        <property type="entry name" value="SprT-like_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035240">
        <property type="entry name" value="SprT_Zn_ribbon"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23099:SF0">
        <property type="entry name" value="GERM CELL NUCLEAR ACIDIC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23099">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10263">
        <property type="entry name" value="SprT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17283">
        <property type="entry name" value="Zn_ribbon_SprT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00731">
        <property type="entry name" value="SprT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SprT-like" evidence="2">
        <location>
            <begin position="464"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="399"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="269"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="281"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="319"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="334"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="422"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAF99732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="712" mass="79043" checksum="FB2BF0F1D52B88A6" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BXW6</accession>
    <name>A0A177BXW6_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6604 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1263348</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441559">
        <property type="protein sequence ID" value="OAG00364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030729.1">
        <property type="nucleotide sequence ID" value="XM_018185232.1"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177BXW6"/>
    <dbReference type="GeneID" id="28768718"/>
    <dbReference type="InParanoid" id="A0A177BXW6"/>
    <dbReference type="OrthoDB" id="5238236at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046539">
        <property type="entry name" value="DUF6604"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38795">
        <property type="entry name" value="DUF6604 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38795:SF1">
        <property type="entry name" value="DUF6604 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20253">
        <property type="entry name" value="DUF6604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6604" evidence="2">
        <location>
            <begin position="14"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1041"/>
            <end position="1113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1186"/>
            <end position="1210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1079"/>
            <end position="1092"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG00364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="1327" mass="150259" checksum="AA8F33A0074D55D4" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BXZ7</accession>
    <name>A0A177BXZ7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_301429</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441559">
        <property type="protein sequence ID" value="OAG00394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030759.1">
        <property type="nucleotide sequence ID" value="XM_018185796.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BXZ7"/>
    <dbReference type="GeneID" id="28769282"/>
    <dbReference type="InParanoid" id="A0A177BXZ7"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG00394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="151" mass="16283" checksum="BB2290035404C13D" modified="2016-09-07" version="1">MQVAIRRLCAAPHAAQSIMTEEGASSSHNERQTGTPRPLDVQRVGINAEAWQCLQIAEIEDPLLVEGGSARTSSTASCCPSHGVSGSRGWVRIRVANEVSVFRGDGCRSGKGSQTLTLPGPCSLNRFPEKDRLWRGARASGWCRRGRVKLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BY87</accession>
    <name>A0A177BY87_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">GroES-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CC84DRAFT_1157210</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441562">
        <property type="protein sequence ID" value="OAF99289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029655.1">
        <property type="nucleotide sequence ID" value="XM_018177002.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BY87"/>
    <dbReference type="STRING" id="1460663.A0A177BY87"/>
    <dbReference type="GeneID" id="28760488"/>
    <dbReference type="InParanoid" id="A0A177BY87"/>
    <dbReference type="OrthoDB" id="5363962at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003939">
        <property type="term" value="F:L-iditol 2-dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006062">
        <property type="term" value="P:sorbitol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05285">
        <property type="entry name" value="sorbitol_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045306">
        <property type="entry name" value="SDH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161">
        <property type="entry name" value="SORBITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161:SF7">
        <property type="entry name" value="SORBITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="9">
        <location>
            <begin position="30"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAF99289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="394" mass="42244" checksum="ED59297394A7E4C7" modified="2016-09-07" version="1">MAPSALADIYPIPARHYSKPSTVVASVLYGPRDLRLETRHISDPGPHELQVAIKATGVCGSDVSYYNKFRNGDLQAVQPLSLGHESAGVVVAIGEAVTGFQIGERVALEVGVPCDNCRSCQRGRYNLCPGMRFRSSAKSVPHFQGTLQERINHPAKWCHKIPQHVSMESAALLEPLSVAIHATRRASIEQGDTVTVFGAGTVGLLTAAMAKLSGATTVVIADIDSGRVNYALANGFAHKGYIVHPRRHLSETAEKLAAAKELAEDVMQIASLNDLDFEGADVTFDCTGKEICMQAGLYSTRPGGKLIMVGMGTPIQTLPMSASHLKEVDIIGIFRYANTYPTGIKILSSGALPSLDNMVTHRFRGLAAAKEAFELAGKTTDKDGRLVIKILVEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BYA9</accession>
    <name>A0A177BYA9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA-directed DNA polymerase</fullName>
            <ecNumber evidence="3">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CC84DRAFT_1128902</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA polymerase delta/II small subunit family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="3"/>
    <dbReference type="EMBL" id="KV441559">
        <property type="protein sequence ID" value="OAG00315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030680.1">
        <property type="nucleotide sequence ID" value="XM_018175813.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BYA9"/>
    <dbReference type="FunCoup" id="A0A177BYA9">
        <property type="interactions" value="885"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177BYA9"/>
    <dbReference type="GeneID" id="28759299"/>
    <dbReference type="InParanoid" id="A0A177BYA9"/>
    <dbReference type="OrthoDB" id="3763at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043625">
        <property type="term" value="C:delta DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006273">
        <property type="term" value="P:lagging strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07387">
        <property type="entry name" value="MPP_PolD2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.430:FF:000002">
        <property type="entry name" value="DNA polymerase delta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007185">
        <property type="entry name" value="DNA_pol_a/d/e_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040663">
        <property type="entry name" value="DNA_pol_D_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024826">
        <property type="entry name" value="DNA_pol_delta/II_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041863">
        <property type="entry name" value="PolD2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10416">
        <property type="entry name" value="DNA POLYMERASE DELTA SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10416:SF0">
        <property type="entry name" value="DNA POLYMERASE DELTA SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18018">
        <property type="entry name" value="DNA_pol_D_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04042">
        <property type="entry name" value="DNA_pol_E_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA polymerase delta subunit OB-fold" evidence="11">
        <location>
            <begin position="47"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="DNA polymerase alpha/delta/epsilon subunit B" evidence="10">
        <location>
            <begin position="219"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF18018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OAG00315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="496" mass="54466" checksum="DB0227E8E16438C7" modified="2016-09-07" version="1">MASSDGILLKGAPFEDPAAVSSRNASAYRPLHTFELPKGSEKHYAHQFADMYFVRLAQLKEAVKQKAHEAWDAFELAGDKAKYVERVLDVRQGELCWVVGTVYMEMAMKPNVLDDISKEHWIAAPPSRDTYVSPSGTDDMMLEDESGRLRVAGNSLNSHYVTGCILAALGTEQADGSFQVIATQYADLPRQPQRWEAEDASLTVAKEPTPKREKAGKLAIVSGLDMTGKDEDDVTLDLLVEYLSGEAGGPDQASASSITRLVIAGNSLSNASPILSREEFDVRKGAKRNYGYDSSSYNATPAEKFDAFLAEILPALPVSVLPGEQDPANVALPQQPLHPALFPLSRAYQYPPALANETLEGLDLVTNPWEADVEGWRILGTAGQTLDDLLKYVDGVWPLDAMEMMLRWRCIAPTAPDTLWCYPFQDDDPLILKECPHIYFAGNREKFQAKFVKGPAGQQVLIVGVPKFSKTGQIVLVDMETLEVETVKLGYVKPGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BYL2</accession>
    <name>A0A177BYL2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative bicyclomycin resistance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CC84DRAFT_1131330</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441562">
        <property type="protein sequence ID" value="OAF99429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029795.1">
        <property type="nucleotide sequence ID" value="XM_018175895.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BYL2"/>
    <dbReference type="STRING" id="1460663.A0A177BYL2"/>
    <dbReference type="GeneID" id="28759381"/>
    <dbReference type="InParanoid" id="A0A177BYL2"/>
    <dbReference type="OrthoDB" id="9986881at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF138">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="39"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="107"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="130"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="166"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="194"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="272"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="309"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="350"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="379"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="416"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="445"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="41"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAF99429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="485" mass="52751" checksum="391FD0D7CB048F7E" modified="2016-09-07" version="1">MGNDRPFPKTIEDRESYVVMFDGPNDPWHPMGWSFSKKCCVATIVCYCTLVATFDSAVFSPAAAQASQDLSVGKEVGALATSLYVLGFAFGPLIWGPGCELMGRRMPLIVGSFGCAVFTLASAVAKDIQTVIICRFFAGVFGSSPLCVVPGILADLFDDYQRGPSIAIYALTVFAGPLAASSIGGFIVDSYLRWRWTLYLPAIMGFFAVFLLLLFLEETHAGTVLIAKAAHIRQETGNWSIHAEHARVEVDTHALLRKYLLRPLRMLVTEPIVLLISIYMSFIYGLTYCLVGAYPYVFQHTYGMNKGTAALPLIAVILGLCLAVCFIIWQQLQSQKTSQSGKGTSEPEVRLLPVIVGAIVFPIGLFWFSWTAFTPSVHWMLPTASGVLTGFGLLCIFMPCFNYLIEAYLPLAASTVAANVMLRSGIAGGFPLFSVHMFANLGIQWAGTLLGCLAVAMIPIALGFRAYGAKFRRRSKLLSGSKAIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2023-06-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BZ73</accession>
    <name>A0A177BZ73_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_375090</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441561">
        <property type="protein sequence ID" value="OAF99649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030015.1">
        <property type="nucleotide sequence ID" value="XM_018185965.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BZ73"/>
    <dbReference type="GeneID" id="28769451"/>
    <dbReference type="InParanoid" id="A0A177BZ73"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAF99649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="150" mass="16769" checksum="AA30596DD87D15A5" modified="2016-09-07" version="1">MHFSGSDPLNIPHESGFLSRFSLGFSYRSHTARYDNPHHTQVRYRKLLAATASRRVSTNSSSLVIGFGIFVRLGVHQKYMVDGEQASARAYVQPLAVSSFCSRCVHTDVQMTVGSVGSLTVCRSLFVCSRVLCRIPVFRFCYANRTMVPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C0H2</accession>
    <name>A0A177C0H2_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Elongation factor 1 alpha-like protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Elongation factor 1-alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CC84DRAFT_1222427</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the Dom34-Hbs1 complex, also named Pelota-HBS1L complex, composed of dom34 and hbs1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV441560">
        <property type="protein sequence ID" value="OAG00110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030475.1">
        <property type="nucleotide sequence ID" value="XM_018183367.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C0H2"/>
    <dbReference type="FunCoup" id="A0A177C0H2">
        <property type="interactions" value="50"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177C0H2"/>
    <dbReference type="GeneID" id="28766853"/>
    <dbReference type="InParanoid" id="A0A177C0H2"/>
    <dbReference type="OrthoDB" id="342024at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990533">
        <property type="term" value="C:Dom34-Hbs1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002184">
        <property type="term" value="P:cytoplasmic translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01883">
        <property type="entry name" value="EF1_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16267">
        <property type="entry name" value="HBS1-like_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000020">
        <property type="entry name" value="Translation elongation factor EF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000204">
        <property type="entry name" value="Translation elongation factor Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054696">
        <property type="entry name" value="GTP-eEF1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015033">
        <property type="entry name" value="HBS1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050100">
        <property type="entry name" value="TRAFAC_GTPase_members"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23115">
        <property type="entry name" value="TRANSLATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22594">
        <property type="entry name" value="GTP-eEF1A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08938">
        <property type="entry name" value="HBS1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="Tr-type G" evidence="14">
        <location>
            <begin position="433"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="272"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="363"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="272"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00063537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00074866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OAG00110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="849" mass="91999" checksum="C57D6567669B5037" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C0H7</accession>
    <name>A0A177C0H7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">TMS membrane protein/tumor differentially expressed protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CC84DRAFT_1154387</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TDE1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441558">
        <property type="protein sequence ID" value="OAG00985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031350.1">
        <property type="nucleotide sequence ID" value="XM_018176884.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C0H7"/>
    <dbReference type="FunCoup" id="A0A177C0H7">
        <property type="interactions" value="522"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177C0H7"/>
    <dbReference type="GeneID" id="28760370"/>
    <dbReference type="InParanoid" id="A0A177C0H7"/>
    <dbReference type="OrthoDB" id="5963193at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045121">
        <property type="term" value="C:membrane raft"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005016">
        <property type="entry name" value="TDE1/TMS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10383">
        <property type="entry name" value="SERINE INCORPORATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10383:SF9">
        <property type="entry name" value="SERINE INCORPORATOR, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03348">
        <property type="entry name" value="Serinc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008057616" evidence="8">
        <location>
            <begin position="24"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="18"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="50"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="101"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="139"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="162"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="201"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="234"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="267"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="307"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="417"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="457"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="377"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="377"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="388"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="398"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAG00985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="486" mass="53303" checksum="3AA74FCD26D7C593" modified="2016-09-07" version="1">MGALLSIPMLALPSVGTLWGVAASCCGAATCSAVFGSCGGKCGNSIATRIAYALILLFNSIVSWIMLTDWAMKKLSHLTLDYVDIKCHGEQCYGYVAVQRINFALGFFHVIMAVMLIGVRSSKDGRAPIQNGFWGPKIIAWLAMVVLTFFIPNSFFIVWGNYFAMIGACLFLLIGLILLVDLAHNWAEYCQEKIEVTESRVWTGMLVGSALFMYMSSFAMTVVMYIFFARSGCGMNQAAITINLILLLLSSIVSIHPAVQNVNPRAGLAQSAIVAIYCTYLTMSAVGMEPDDHQCNPLIRARGTRKATIIIGAIVTFVTVAYTTTRAATYGLALGAQGNSYGNGYTQVGTEDYEHGLVTQQPESRREMRAAALRAAVESGSLPASALDESDSDDEDEGPSKAPRDDERNATQYNYTLFHVIFFLSTTWVATLLTTNFDEKDMQNDFVPVGRTYWASWAKIISAWVCYGIYTWSLVAPLVLPERFDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C0V6</accession>
    <name>A0A177C0V6_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CC84DRAFT_302083</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441559">
        <property type="protein sequence ID" value="OAG00438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030803.1">
        <property type="nucleotide sequence ID" value="XM_018185800.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C0V6"/>
    <dbReference type="STRING" id="1460663.A0A177C0V6"/>
    <dbReference type="GeneID" id="28769286"/>
    <dbReference type="InParanoid" id="A0A177C0V6"/>
    <dbReference type="OrthoDB" id="444631at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF129">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="126"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="242"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="288"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="323"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="143"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAG00438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="486" mass="53607" checksum="8E9744F4F8242640" modified="2016-09-07" version="1">MPRLDQATGSRPFHHTHPGTGEYQGGALPSFGEVLFWSTGSKSSPLQNEHDGKFDQQEPVLTHPYLGNHSTGIFTSIPYVSDRCACLAMMLHPLLYIRQSFSIPHAPGIQPLPPPRLFDESRAADIVAGNVLLQLVGTLFFVLRIYSRLWLTKSWKVEDSLLTIAWVFATAFSTCQYGQVAHGAGHHLGVVLHNDPKDAVESQKWAYAANLILFPALAFPKLSICDAYSRIFGESLMNRRMIYALIVLVAIPNIPFFFLSVFQCTPIHVYWTEGRPFEKCHLIDFKMFYIHGGLNIFCDVALMIIVMPRVLELHVGRRQKWALVGIVGLGSLAVIAGIVRMTRLSLTLSKPNFDASWDAYDVSIWTSTEIYVSLICAAAPGIKPVVSLVLPKLLGSSLGSRARTTTGDGHGGAAPIELHSKMRRATIGSARTRRNTHESILDEADGPYAEVGRGVDTESLGSKEVKPARRHTKKVSEILIIQSNAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C1K4</accession>
    <name>A0A177C1K4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF7730 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1180659</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441559">
        <property type="protein sequence ID" value="OAG00678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031043.1">
        <property type="nucleotide sequence ID" value="XM_018180492.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C1K4"/>
    <dbReference type="STRING" id="1460663.A0A177C1K4"/>
    <dbReference type="GeneID" id="28763978"/>
    <dbReference type="InParanoid" id="A0A177C1K4"/>
    <dbReference type="OrthoDB" id="4757095at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056632">
        <property type="entry name" value="DUF7730"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38790:SF4">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38790">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24864">
        <property type="entry name" value="DUF7730"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7730" evidence="1">
        <location>
            <begin position="125"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG00678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="350" mass="40253" checksum="7828A9BD38429BFA" modified="2016-09-07" version="1">MTRLYQSPCLFVLQRPDCAPRSLTQLILTSLLHRTPSSTIQTTPVTRTGMGSYSAYDHAYDSRFKIPSTSSPTAVKRFLETIKGGEGNEEKHYARWRNEQDERWRARLPRKSERAALSLNAKSSSQLQSRFFQLPLEVRDDIYQYIFDGGTLRLDVQEKVDGKVVRNKEPYRLRNLEPQQCVAILQACKRTYVEAAHLLYTTHTFMFSDLTSFLCFERLVPSHHWHRIKSIGITWDYDEVGHDFEYDHLPCPTNEETWKEVCRAVSEMKGLEHLRVDLEKCPMNPYQASDLDLQQPLRDITAPIVLDLFVYGKRKALTAICGCGCGGIEGRCYGSVAFDQTSLDYESDSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C1X1</accession>
    <name>A0A177C1X1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1230825</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441559">
        <property type="protein sequence ID" value="OAG00630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030995.1">
        <property type="nucleotide sequence ID" value="XM_018183708.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C1X1"/>
    <dbReference type="GeneID" id="28767194"/>
    <dbReference type="InParanoid" id="A0A177C1X1"/>
    <dbReference type="OrthoDB" id="3767489at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG00630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="415" mass="45516" checksum="FD4E698BD5FFAD1E" modified="2016-09-07" version="1">MLPQCASWSFQEAQGDNCSEISCLGKHRPHHLPLALNAQSLVPLIRTITHGTAKSVLRPSTRCKPDQVEIGFGSAKAGGHRRCNSEEASETDGKALRFLAVGSKTVYMMLYRWHSIAWLFAKAHEASQSTGECSSSVKACCAEAIESSRSFPAKVAAAEMSCNPMPQGLARFTHFGPQNLDFSCKTPLSADTIPFYKPLCVLSKSATATMPIFVTIDAACSDDRPFLAKDLVEGAYPLALVSKIDFAVLRLDERIKSAQFAETGPIERPPSKDDRHKFTLWRGTVSSPDAYKFPWEYAFREHANLALMATFQAVFEHLRPLWSELETHETVSPAGFGLQFVGVGEAGWSLDQHGCLALAQLSRDGSEIEWLYVKAEVGDNQAPLPAGNVLPIDPLPTANKPLGFKKFSMTPKTRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C227</accession>
    <name>A0A177C227_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">D-xylulose reductase</fullName>
            <ecNumber evidence="9">1.1.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Xylitol dehydrogenase A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CC84DRAFT_1221354</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Xylitol dehydrogenase which catalyzes the conversion of xylitol to D-xylulose. Xylose is a major component of hemicelluloses such as xylan. Most fungi utilize D-xylose via three enzymatic reactions, xylose reductase (XR), xylitol dehydrogenase (XDH), and xylulokinase, to form xylulose 5-phosphate, which enters pentose phosphate pathway.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="8">Carbohydrate degradation; L-arabinose degradation via L-arabinitol; D-xylulose 5-phosphate from L-arabinose (fungal route): step 4/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.9" evidence="9"/>
    <dbReference type="EMBL" id="KV441558">
        <property type="protein sequence ID" value="OAG00787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031152.1">
        <property type="nucleotide sequence ID" value="XM_018183266.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C227"/>
    <dbReference type="STRING" id="1460663.A0A177C227"/>
    <dbReference type="GeneID" id="28766752"/>
    <dbReference type="InParanoid" id="A0A177C227"/>
    <dbReference type="OrthoDB" id="3941538at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046526">
        <property type="term" value="F:D-xylulose reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003939">
        <property type="term" value="F:L-iditol 2-dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006062">
        <property type="term" value="P:sorbitol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05285">
        <property type="entry name" value="sorbitol_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000068">
        <property type="entry name" value="Sorbitol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045306">
        <property type="entry name" value="SDH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161">
        <property type="entry name" value="SORBITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161:SF9">
        <property type="entry name" value="SORBITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="12">
        <location>
            <begin position="21"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00026119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OAG00787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="484" mass="52658" checksum="3F5E601D813B9724" modified="2016-09-07" version="1">MVTSTRIEEMKNPSIVLYKAGHAKVQDAPVPEIVDPHDVLVRIAFVGVCGSDVHFYRHGGISRMVDPAVGITMGHEASGVISAIGSSVTRVRPGDRVAIEPGQPCRFCRPCKSGSYHLCKNMRFAADPGPPATQGTLSKYYRIAEDFVYKVPESMSLEETVLVEPTSVAVHAVRLGDVRPGETVVVMGSGTIGLLVGNVARQFGAHRVVLVDVLPRKLEFAKGFLECETFLSDREHSAEQNAAALLEALGLEEIDTVIECSGVSVSIETGIYVLRGGGKYVQTGMGRPKMEFPMTVMSEKELVVRGCFRYNTGDYDLAVSMIAKGLINVKPMISSTSEFEDATGAWEKTARGEGIKNLIRGTDWKSHKKIGAMQAAGNNIGPSLDETFADATNSYKHKHTVASGPNIDHAETYRQENIKNLEKHTPTPSPISTKVPTCTIARREMPSIYSSTLSKSLRCRQFLIPQHQQPHGATSHTPKAQKNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C241</accession>
    <name>A0A177C241_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Kinetochore protein Spc24</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CC84DRAFT_1168161</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the NDC80 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Chromosome</location>
            <location evidence="11">Centromere</location>
            <location evidence="11">Kinetochore</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the SPC24 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441558">
        <property type="protein sequence ID" value="OAG00959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031324.1">
        <property type="nucleotide sequence ID" value="XM_018179330.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C241"/>
    <dbReference type="FunCoup" id="A0A177C241">
        <property type="interactions" value="90"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177C241"/>
    <dbReference type="GeneID" id="28762816"/>
    <dbReference type="InParanoid" id="A0A177C241"/>
    <dbReference type="OrthoDB" id="3344830at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005815">
        <property type="term" value="C:microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031262">
        <property type="term" value="C:Ndc80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11565">
        <property type="entry name" value="RWD_Spc24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013252">
        <property type="entry name" value="Ndc80_Spc24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038066">
        <property type="entry name" value="Spc24_Fungi_globular_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22142">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22142:SF2">
        <property type="entry name" value="KINETOCHORE PROTEIN SPC24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08286">
        <property type="entry name" value="Spc24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143026">
        <property type="entry name" value="Kinetochore globular domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4 11" id="KW-0132">Cell division</keyword>
    <keyword evidence="10 11" id="KW-0137">Centromere</keyword>
    <keyword evidence="3 11" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 11" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="5 11" id="KW-0498">Mitosis</keyword>
    <keyword evidence="8 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OAG00959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="196" mass="21907" checksum="3F95349E6112FE63" modified="2016-09-07" version="1">MLLDEDPASLIAQCTSHFKLDSDRSALLRISDSLATLSSFRQQHTSSLQSTLTRLNRTHQTLASNHNHTLSQHNPTTHAAEILRLDTEKFKIAKQASDLEMEGERLEGELSRLGGVLGELEAEGVEGGEREKGPEEDATVLKLKVYRSLGIDVEADPTGQYNKAVIRNAAKGDVHVVNIDPKFSRNFYTNYFWRTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C2E8</accession>
    <name>A0A177C2E8_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="15">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CC84DRAFT_222663</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Protein phosphatase that specifically binds to and dephosphorylates the molecular chaperone Hsp90. Dephosphorylation positively regulates the Hsp90 chaperone machinery.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:20630"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:47005"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the PPP phosphatase family. PP-5 (PP-T) subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="15"/>
    <dbReference type="EMBL" id="KV441557">
        <property type="protein sequence ID" value="OAG01823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032188.1">
        <property type="nucleotide sequence ID" value="XM_018185633.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C2E8"/>
    <dbReference type="FunCoup" id="A0A177C2E8">
        <property type="interactions" value="1179"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177C2E8"/>
    <dbReference type="GeneID" id="28769119"/>
    <dbReference type="InParanoid" id="A0A177C2E8"/>
    <dbReference type="OrthoDB" id="445564at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07417">
        <property type="entry name" value="MPP_PP5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000039">
        <property type="entry name" value="Serine/threonine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041753">
        <property type="entry name" value="PP5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013235">
        <property type="entry name" value="PPP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051134">
        <property type="entry name" value="PPP_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45668">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45668:SF5">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08321">
        <property type="entry name" value="PPP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF033096">
        <property type="entry name" value="PPPtase_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0464">Manganese</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="17">
        <location>
            <begin position="279"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="14"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="14">
        <location>
            <position position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00059747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR033096-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="OAG01823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="479" mass="53933" checksum="BA2ACD035DAC4695" modified="2016-09-07" version="1">MKPSRSRTGPLPWSGTPRPSRPTTRSPRSTQIVHRSVQSAPHATTVLTSAQANIKLESYGLAVHDADKAIELDPNNVKAFYRRASANTAILHHREALRDWKLVVKKAPSDATAKVRLADCERIVKRDAFLKAIEVEDAPSAAEGLDLEHMAVDSSYDGAKLGDKITLEFVEDMIERFKNGKKLALKYVYQIIIAVMEIVRNEPTMVEVDVEEGQEITVCGDTHGQYFDLLNIFKLAGKPSEKHMFLFNGDFVDRGSWSTEICLLLYAYKWLYPSKFFLNRGNHETDDMNRMYGFEGECRAKYTKDRVFKLFSESFSALPLATLIGKKYFVLHGGLFSDDKVTLDDVRKLDRFKQRQPGQSGLMMEMLWTDPQTTPGRGPSKRGVGLQFGPDVTKRFCENNGLEAIIRSHEVRMDGYEVEHDGKCITVFSAPHYCDSTGNKGAFIKIGPEYKLNFTQFDAVPHPNVKPMAYASNGLQGML</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C2P1</accession>
    <name>A0A177C2P1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cyclin-dependent kinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CC84DRAFT_276880</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the WHI5/NRM1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441558">
        <property type="protein sequence ID" value="OAG01122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031487.1">
        <property type="nucleotide sequence ID" value="XM_018185725.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C2P1"/>
    <dbReference type="STRING" id="1460663.A0A177C2P1"/>
    <dbReference type="GeneID" id="28769211"/>
    <dbReference type="InParanoid" id="A0A177C2P1"/>
    <dbReference type="OrthoDB" id="2359117at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033309">
        <property type="term" value="C:SBF transcription complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000082">
        <property type="term" value="P:G1/S transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039198">
        <property type="entry name" value="Srl3/Whi5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013734">
        <property type="entry name" value="TF_Nrm1/Whi5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28246">
        <property type="entry name" value="G1-SPECIFIC TRANSCRIPTIONAL REPRESSOR WHI5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28246:SF1">
        <property type="entry name" value="G1-SPECIFIC TRANSCRIPTIONAL REPRESSOR WHI5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08528">
        <property type="entry name" value="Whi5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0678">Repressor</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="184"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="284"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="377"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="16"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="75"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="185"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="231"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAG01122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="408" mass="43759" checksum="7FD2DEDD01A9F118" modified="2016-09-07" version="1">MTAPMPSLYQRELPDSQESYISAASSTFSAPRLPSASSNLSTSTAGDTEITSPPLSKTPSAQKTSIVHAFPPSPDRPRGPDTLRIDAANAPRTGDTAASPMSLDSPAMQGLKRAADGSVKGSEIINESPTAPTMGHKRNKSMEAGSSGRIGQLSAQLKTRLSYAMVKVQNNWEKQSIDELEERISQQGSPNSVANRTPGSRPAFASPTTAERRRRPSGVSENSDHMMISPGQRTPSDPSRSYASTPSSLWRPGTKPTLNAAVNLISVTGANTGLMLGPAPEFESRRKRRSSASFHAPPLLGSSQRKHFSDLGAGLRTPATPRPGILRMPSQQAEKDAVDTLLFMSSPNNSGRLPHTSADARAARHDFEHPQRRVMFENFPSTERPAGHLHSSAPSSQSTAYYRAEPSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C2X5</accession>
    <name>A0A177C2X5_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">non-reducing end alpha-L-arabinofuranosidase</fullName>
            <ecNumber evidence="4">3.2.1.55</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CC84DRAFT_1154435</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Alpha-L-arabinofuranosidase involved in the degradation of arabinoxylan, a major component of plant hemicellulose. Acts only on small linear 1,5-alpha-linked L-arabinofuranosyl oligosaccharides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing alpha-L-arabinofuranoside residues in alpha-L-arabinosides.</text>
            <dbReference type="EC" id="3.2.1.55"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Glycan metabolism; L-arabinan degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 51 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.55" evidence="4"/>
    <dbReference type="EMBL" id="KV441558">
        <property type="protein sequence ID" value="OAG01010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031375.1">
        <property type="nucleotide sequence ID" value="XM_018176887.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C2X5"/>
    <dbReference type="STRING" id="1460663.A0A177C2X5"/>
    <dbReference type="GeneID" id="28760373"/>
    <dbReference type="InParanoid" id="A0A177C2X5"/>
    <dbReference type="OrthoDB" id="3032304at2759"/>
    <dbReference type="UniPathway" id="UPA00667"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046556">
        <property type="term" value="F:alpha-L-arabinofuranosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031222">
        <property type="term" value="P:arabinan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046373">
        <property type="term" value="P:L-arabinose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010720">
        <property type="entry name" value="Alpha-L-AF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055235">
        <property type="entry name" value="ASD1_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43576:SF3">
        <property type="entry name" value="ALPHA-L-ARABINOFURANOSIDASE C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43576">
        <property type="entry name" value="ALPHA-L-ARABINOFURANOSIDASE C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06964">
        <property type="entry name" value="Alpha-L-AF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22848">
        <property type="entry name" value="ASD1_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00813">
        <property type="entry name" value="Alpha-L-AF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-L-arabinofuranosidase C-terminal" evidence="9">
        <location>
            <begin position="309"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAG01010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="506" mass="56726" checksum="22289BD4DEF61FCD" modified="2016-09-07" version="1">MTSFTRIADEGSPSIIVHPDHKIAKINDNIYGGFTEHMGRCIYGGIYDPGNPLSDENGFRKDVIDAMKDLNVPVVRYPGGNFVATYHWLDGVGPRENRPKRPELAWLGLEPNTFGTDEFMKWCEIVGTEPYLCLNFGTGTLDEALGWLEYCNSTQDTYYANLRRKNGREEPYNVKYWALGNECWGPWQVAQLTKEDYAKKAYQWAKALKLLDPSIVLILCGETGYSSWDYYVLKECVTWSVHGLGGDRTKSLIDMHSIHVYTADKEHLANATAPRGAERAIQMASALIDLARIENGVPETVPRQTICFDEWNVWDPIRAPGELGAEEKYTLSDALAVSVFLNGFIRQAKDLGMANIAQSINVISPLMTNKDGIVKQTIWWPLLLFSKYMRGHSVAVNVRAPEYTGRTNPAWIRATIETPYLDVSASISDDGHMSLAVANLNEEKAFDVKVEGVKKGEVKVYTVDGENVDVANTADEQKVGIKESSWDGVGKFRFGKHSFTLLRWKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C2Y0</accession>
    <name>A0A177C2Y0_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Mitochondrial inner membrane protease subunit</fullName>
            <ecNumber evidence="11">3.4.21.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CC84DRAFT_1055106</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S26 family. IMP2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.-" evidence="11"/>
    <dbReference type="EMBL" id="KV441558">
        <property type="protein sequence ID" value="OAG01269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031634.1">
        <property type="nucleotide sequence ID" value="XM_018173531.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C2Y0"/>
    <dbReference type="FunCoup" id="A0A177C2Y0">
        <property type="interactions" value="354"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177C2Y0"/>
    <dbReference type="GeneID" id="28757017"/>
    <dbReference type="InParanoid" id="A0A177C2Y0"/>
    <dbReference type="OrthoDB" id="9996127at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042720">
        <property type="term" value="C:mitochondrial inner membrane peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006627">
        <property type="term" value="P:protein processing involved in protein targeting to mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06530">
        <property type="entry name" value="S26_SPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.109.10">
        <property type="entry name" value="Umud Fragment, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037730">
        <property type="entry name" value="IMP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000223">
        <property type="entry name" value="Pept_S26A_signal_pept_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019533">
        <property type="entry name" value="Peptidase_S26"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02227">
        <property type="entry name" value="sigpep_I_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46041">
        <property type="entry name" value="MITOCHONDRIAL INNER MEMBRANE PROTEASE SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46041:SF2">
        <property type="entry name" value="MITOCHONDRIAL INNER MEMBRANE PROTEASE SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10502">
        <property type="entry name" value="Peptidase_S26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00727">
        <property type="entry name" value="LEADERPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="LexA/Signal peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="3 11" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Peptidase S26" evidence="12">
        <location>
            <begin position="2"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="20"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="69"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR600223-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF10502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OAG01269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="193" mass="21815" checksum="CA265A96D7772E06" modified="2016-09-07" version="1" fragment="single">CAAVFFRDHFYTIDSVNGSSMAPTLSPLAHETGAKDRIFIKRGFDRRDIQRGDVITFWKPHKQSEISIKRVVGVEGDTVYPHRGYACNPEVVNGRRVEGWDGLGSREWALGGDGEVELGKVVVPNGHVWVEGDNWRRSYDSCDFGPVSLGLVDGKARWVWRDWLRLQPVGDEREKGRSKSMVVAGKGRVERRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C370</accession>
    <name>A0A177C370_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Concanavalin A-like lectin/glucanase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1127437</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441557">
        <property type="protein sequence ID" value="OAG01611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031976.1">
        <property type="nucleotide sequence ID" value="XM_018175774.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C370"/>
    <dbReference type="STRING" id="1460663.A0A177C370"/>
    <dbReference type="GeneID" id="28759260"/>
    <dbReference type="InParanoid" id="A0A177C370"/>
    <dbReference type="OrthoDB" id="2862635at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070007">
        <property type="term" value="F:glutamic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13426">
        <property type="entry name" value="Peptidase_G1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.700">
        <property type="entry name" value="Peptidase G1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000250">
        <property type="entry name" value="Peptidase_G1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038656">
        <property type="entry name" value="Peptidase_G1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37536:SF1">
        <property type="entry name" value="ASPERGILLOPEPSIN, PUTAITVE (AFU_ORTHOLOGUE AFUA_7G01200)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37536">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_3G02970)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01828">
        <property type="entry name" value="Peptidase_A4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00977">
        <property type="entry name" value="SCYTLDPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0430">Lectin</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008057727" evidence="1">
        <location>
            <begin position="19"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG01611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="238" mass="24658" checksum="FB45ED5ED3082C2E" modified="2016-09-07" version="1">MKVYILLGALHWALVTRAAYDRNRGGAVLKAPADDAFRTVSGTFTVPANLTGDNRLSIWVGIGDSLTQTYVVGGGVSFNKTVSTWSAFFPGAPTDATAEVPAAIGDNMTITINVDAGAAGLVTIENLTQNKKTTQTASAPPSAAPTALTALVADWWVQAYQVVPGELVKVPEFGTVSFTGISAITQKGITVPFSGAGAYEIQGTSGEMWSNTTISSSGILVRRRNGPGCDASDPCGNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C3G9</accession>
    <name>A0A177C3G9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Peroxisomal ABC transporter-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CC84DRAFT_1128701</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily. ABCD family. Peroxisomal fatty acyl CoA transporter (TC 3.A.1.203) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV441558">
        <property type="protein sequence ID" value="OAG01210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031575.1">
        <property type="nucleotide sequence ID" value="XM_018175807.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C3G9"/>
    <dbReference type="FunCoup" id="A0A177C3G9">
        <property type="interactions" value="459"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177C3G9"/>
    <dbReference type="GeneID" id="28759293"/>
    <dbReference type="InParanoid" id="A0A177C3G9"/>
    <dbReference type="OrthoDB" id="422637at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005324">
        <property type="term" value="F:long-chain fatty acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015910">
        <property type="term" value="P:long-chain fatty acid import into peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007031">
        <property type="term" value="P:peroxisome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042760">
        <property type="term" value="P:very long-chain fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03223">
        <property type="entry name" value="ABCD_peroxisomal_ALDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050835">
        <property type="entry name" value="ABC_transporter_sub-D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11384:SF67">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY D MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11384">
        <property type="entry name" value="ATP-BINDING CASSETTE, SUB-FAMILY D MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06472">
        <property type="entry name" value="ABC_membrane_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="174"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="528"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="748"/>
            <end position="775"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OAG01210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="858" mass="96028" checksum="C85EB3A3DC19314A" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C3R0</accession>
    <name>A0A177C3R0_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 11">Cystathionine beta-synthase</fullName>
            <ecNumber evidence="4 11">4.2.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CC84DRAFT_1127069</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 11">
            <text>L-homocysteine + L-serine = L,L-cystathionine + H2O</text>
            <dbReference type="Rhea" id="RHEA:10112"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:58161"/>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
            <dbReference type="EC" id="4.2.1.22"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-cysteine biosynthesis; L-cysteine from L-homocysteine and L-serine: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the cysteine synthase/cystathionine beta-synthase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.22" evidence="4 11"/>
    <dbReference type="EMBL" id="KV441557">
        <property type="protein sequence ID" value="OAG01417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031782.1">
        <property type="nucleotide sequence ID" value="XM_018175762.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C3R0"/>
    <dbReference type="FunCoup" id="A0A177C3R0">
        <property type="interactions" value="881"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177C3R0"/>
    <dbReference type="GeneID" id="28759248"/>
    <dbReference type="InParanoid" id="A0A177C3R0"/>
    <dbReference type="OrthoDB" id="728at2759"/>
    <dbReference type="UniPathway" id="UPA00136">
        <property type="reaction ID" value="UER00201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004122">
        <property type="term" value="F:cystathionine beta-synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006535">
        <property type="term" value="P:cysteine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019343">
        <property type="term" value="P:cysteine biosynthetic process via cystathionine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070814">
        <property type="term" value="P:hydrogen sulfide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007089">
        <property type="term" value="P:traversing start control point of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01561">
        <property type="entry name" value="CBS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000003">
        <property type="entry name" value="Cystathionine beta-synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000118">
        <property type="entry name" value="Related to CYS4-cystathionine beta-synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050214">
        <property type="entry name" value="Cys_Synth/Cystath_Beta-Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005857">
        <property type="entry name" value="Cysta_beta_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001216">
        <property type="entry name" value="P-phosphate_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01137">
        <property type="entry name" value="cysta_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10314">
        <property type="entry name" value="CYSTATHIONINE BETA-SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00901">
        <property type="entry name" value="CYS_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 10 11" id="KW-0129">CBS domain</keyword>
    <keyword evidence="11" id="KW-0198">Cysteine biosynthesis</keyword>
    <keyword evidence="7 11" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 11" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="12">
        <location>
            <begin position="371"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00026192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OAG01417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="523" mass="56732" checksum="64DAB49B28AF3F8C" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C470</accession>
    <name>A0A177C470_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1006991</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441556">
        <property type="protein sequence ID" value="OAG02206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032571.1">
        <property type="nucleotide sequence ID" value="XM_018173340.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C470"/>
    <dbReference type="GeneID" id="28756826"/>
    <dbReference type="InParanoid" id="A0A177C470"/>
    <dbReference type="OrthoDB" id="1517790at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.56.110">
        <property type="entry name" value="Protein of unknown function DUF2237"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018714">
        <property type="entry name" value="DUF2237"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37466">
        <property type="entry name" value="SLR1628 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37466:SF1">
        <property type="entry name" value="SLR1628 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09996">
        <property type="entry name" value="DUF2237"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG02206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="132" mass="14077" checksum="460FB88D1948C639" modified="2016-09-07" version="1">MPAKHEQGAIDVKQKNVLHKPLARLSAPASSSKNLPSTVHAGFCTSGSPIAAILTASFLDFSSKQGLDLRGAGVKEGSRYCIDTALWKKAVDGGIKDVQVKLEASHEHKSSISESHLWNFLTETTSGMSSKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C490</accession>
    <name>A0A177C490_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CC84DRAFT_1189810</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441557">
        <property type="protein sequence ID" value="OAG01490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031855.1">
        <property type="nucleotide sequence ID" value="XM_018181076.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C490"/>
    <dbReference type="STRING" id="1460663.A0A177C490"/>
    <dbReference type="GeneID" id="28764562"/>
    <dbReference type="InParanoid" id="A0A177C490"/>
    <dbReference type="OrthoDB" id="4161332at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051615">
        <property type="entry name" value="Transcr_Regulatory_Elem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313:SF85">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="8">
        <location>
            <begin position="119"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="424"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="424"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAG01490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="518" mass="57156" checksum="5862184F84D8062F" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C512</accession>
    <name>A0A177C512_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PA14 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1221279</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441557">
        <property type="protein sequence ID" value="OAG01807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032172.1">
        <property type="nucleotide sequence ID" value="XM_018183252.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C512"/>
    <dbReference type="STRING" id="1460663.A0A177C512"/>
    <dbReference type="GeneID" id="28766738"/>
    <dbReference type="InParanoid" id="A0A177C512"/>
    <dbReference type="OrthoDB" id="4388755at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1560">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018871">
        <property type="entry name" value="GLEYA_adhesin_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037524">
        <property type="entry name" value="PA14/GLEYA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10528">
        <property type="entry name" value="GLEYA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51820">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012204402" description="PA14 domain-containing protein" evidence="1">
        <location>
            <begin position="16"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="domain" description="PA14" evidence="2">
        <location>
            <begin position="263"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG01807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="430" mass="44575" checksum="0AB4A4F4E1615AF9" modified="2016-09-07" version="1">MRGSVALLLPVAVSASPIIDKKVLNDLFCKVNDVVLHVLEKDAAATKYCSSFLSIPTLTFSTTATVTPASVTTTTPLTITEDTVTSTQTETATVTDTQTITSTSTRTDYATITSTTSTSTITCLNSAYTYTAPTGVIPGDAAAPAPEGKRGAANYAKPSAIPKDWSQQYISTACSCLSIPTPSTTSTATVTLIPGTITEASTLFETPTATATTTVTSTTTESATVSEEATTTSTLTAYAVATTIASNGVQYRKYTHSFDANRVDGGGFTSTYFKGLSAEFSGSISSLSFATPNWPSGSTTLTLSDGRAFASDYAALLLQGFFIAKETGTHVFTSRGNEVDNYGYAWTGDAAYSAWNDANAAIRSSRTGGGNVDGNAYVSLNAGDAIPLTFLWANGGGVGQNVVRVTMPSGRVVTNHAGYFVQACSSSVFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C5V6</accession>
    <name>A0A177C5V6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Macro domain-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1008052</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441556">
        <property type="protein sequence ID" value="OAG02269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032634.1">
        <property type="nucleotide sequence ID" value="XM_018173347.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C5V6"/>
    <dbReference type="STRING" id="1460663.A0A177C5V6"/>
    <dbReference type="GeneID" id="28756833"/>
    <dbReference type="InParanoid" id="A0A177C5V6"/>
    <dbReference type="OrthoDB" id="6082470at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="entry name" value="Leucine Aminopeptidase, subunit E, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002589">
        <property type="entry name" value="Macro_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="SMART" id="SM00506">
        <property type="entry name" value="A1pp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="Macro domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Macro" evidence="1">
        <location>
            <begin position="39"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG02269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="240" mass="26790" checksum="2581B1C366526207" modified="2016-09-07" version="1">MASTAPSSHLPSIHLLCLEESHITSFTTALRTYNAPSLDITYHHGTLSSLSQSTHFDAIVSPANSYARMDGGFDDALSRALSPADDYMALTRVASEALYAEHRGFLPPGSCMLISLEDTRLRGNAWGCTWLALCPTMKVPQRVEWDREVVYECIYALLAAVDRRNRRLSEEGVERREIRSVLITPLATGYGRWSAERWAAQTVLALKHFAEVVEAGKNWEKKGPVRVMGHVAEVEKTWDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C6I0</accession>
    <name>A0A177C6I0_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tafazzin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1013941</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441556">
        <property type="protein sequence ID" value="OAG02378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032743.1">
        <property type="nucleotide sequence ID" value="XM_018173367.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C6I0"/>
    <dbReference type="STRING" id="1460663.A0A177C6I0"/>
    <dbReference type="GeneID" id="28756853"/>
    <dbReference type="InParanoid" id="A0A177C6I0"/>
    <dbReference type="OrthoDB" id="193467at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="19"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG02378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="546" mass="60641" checksum="115EAC35B8F9CC10" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C6Q5</accession>
    <name>A0A177C6Q5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1179295</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441556">
        <property type="protein sequence ID" value="OAG02380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032745.1">
        <property type="nucleotide sequence ID" value="XM_018180409.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C6Q5"/>
    <dbReference type="GeneID" id="28763895"/>
    <dbReference type="InParanoid" id="A0A177C6Q5"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="19"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="93"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG02380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="154" mass="17486" checksum="DBCCA0C3F398AD36" modified="2016-09-07" version="1">MSSYTSQPHAYDPQPHYESQSQPYHPSQSQSQPQPHHQPHASTSNALTPLPRPQHQHHPSSSSSSSYNATTPQHLTPYDPYANQAPYDPYAAPSPARRPSSQSHHSHHSTRSHRSHHSHRSEREEREIEKRPSLGDTVVLIWESLMGAFSRRKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C7G9</accession>
    <name>A0A177C7G9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Apurinic-apyrimidinic endonuclease 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CC84DRAFT_1165809</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AP endonuclease 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG03593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033958.1">
        <property type="nucleotide sequence ID" value="XM_018178800.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C7G9"/>
    <dbReference type="FunCoup" id="A0A177C7G9">
        <property type="interactions" value="46"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177C7G9"/>
    <dbReference type="GeneID" id="28762286"/>
    <dbReference type="InParanoid" id="A0A177C7G9"/>
    <dbReference type="OrthoDB" id="7663182at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017005">
        <property type="term" value="F:3'-tyrosyl-DNA phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003906">
        <property type="term" value="F:DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008311">
        <property type="term" value="F:double-stranded DNA 3'-5' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00019">
        <property type="entry name" value="AP2Ec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.150:FF:000001">
        <property type="entry name" value="Probable endonuclease 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.150">
        <property type="entry name" value="Divalent-metal-dependent TIM barrel enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00152">
        <property type="entry name" value="Nfo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001719">
        <property type="entry name" value="AP_endonuc_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018246">
        <property type="entry name" value="AP_endonuc_F2_Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00587">
        <property type="entry name" value="nfo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21445:SF0">
        <property type="entry name" value="APURINIC-APYRIMIDINIC ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21445">
        <property type="entry name" value="ENDONUCLEASE IV ENDODEOXYRIBONUCLEASE IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00518">
        <property type="entry name" value="AP2Ec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="Xylose isomerase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00730">
        <property type="entry name" value="AP_NUCLEASE_F2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51432">
        <property type="entry name" value="AP_NUCLEASE_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="11" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0540">Nuclease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Xylose isomerase-like TIM barrel" evidence="10">
        <location>
            <begin position="152"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="434"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="58"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="434"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="473"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OAG03593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="483" mass="53549" checksum="30C5E975E7DF4BB3" modified="2016-09-07" version="1">MSSDSSLSAPPDDIQPPPAAYETDPLAEKAVNGKKRKAETATNASKVTKRTRKTTVTADTEPNDNGSADKSVEATKPRKRAPKTKAEEETIEEKVVVEDEKGTTVKATQKKSRKKKEENVAPLAERTTGSKLRVGAHVSAAGGIHNAVTNLLHIGANAFALFLKSQRTWKNPELNPEHAQLFMDGCKHHNIDAAECCVPHGSYLVNLAHPDEERKKQAYDSFHDDLTRCHKAGIKYYNFHPGNAAATTREGGIKLIAEAINKVHKDPATGAVVPLLETMATLGNTIGGQFKDIADIIELVEDKERVGVCLDTCHVFAAGYDLRTPEAYERTMKEFEDTIGLKYLKALHVNDSKAPLYSFRDLHARIGTGYLGLAAFHHLVNDKRLHGLPMVLETPIDKKDENGKKFEDKSVWAREIKMLEQLVDMDIESDEFKKMEAELHEEGSSERERIGDQVKKRAEKAAPKKKGKKKVESEDEADEEDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C7T9</accession>
    <name>A0A177C7T9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Kinesin light chain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1197368</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG03713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034078.1">
        <property type="nucleotide sequence ID" value="XM_018181518.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C7T9"/>
    <dbReference type="STRING" id="1460663.A0A177C7T9"/>
    <dbReference type="GeneID" id="28765004"/>
    <dbReference type="InParanoid" id="A0A177C7T9"/>
    <dbReference type="OrthoDB" id="674604at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF11">
        <property type="entry name" value="HET-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
        <property type="entry name" value="NB-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13374">
        <property type="entry name" value="TPR_10"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="2">
        <location>
            <begin position="25"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="NB-ARC" evidence="1">
        <location>
            <begin position="265"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG03713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="886" mass="99853" checksum="DC67F82909586A88" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C8L2</accession>
    <name>A0A177C8L2_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Trafficking protein particle complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_1097998</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Plays a key role in the late stages of endoplasmic reticulum to Golgi traffic.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Part of the multisubunit TRAPP (transport protein particle) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Golgi apparatus</location>
            <location evidence="7">cis-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the TRAPP small subunits family. BET3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG03189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033554.1">
        <property type="nucleotide sequence ID" value="XM_018174746.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C8L2"/>
    <dbReference type="FunCoup" id="A0A177C8L2">
        <property type="interactions" value="367"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177C8L2"/>
    <dbReference type="GeneID" id="28758232"/>
    <dbReference type="InParanoid" id="A0A177C8L2"/>
    <dbReference type="OrthoDB" id="10254842at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990070">
        <property type="term" value="C:TRAPPI protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990071">
        <property type="term" value="C:TRAPPII protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990072">
        <property type="term" value="C:TRAPPIII protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14943">
        <property type="entry name" value="TRAPPC5_Trs31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1380.20:FF:000007">
        <property type="entry name" value="Trafficking protein particle complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1380.20">
        <property type="entry name" value="Trafficking protein particle complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024096">
        <property type="entry name" value="NO_sig/Golgi_transp_ligand-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016696">
        <property type="entry name" value="TRAPP-I_su5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007194">
        <property type="entry name" value="TRAPP_component"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20902">
        <property type="entry name" value="41-2 PROTEIN ANTIGEN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20902:SF0">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04051">
        <property type="entry name" value="TRAPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017479">
        <property type="entry name" value="TRAPP_I_complex_Trs31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111126">
        <property type="entry name" value="Ligand-binding domain in the NO signalling and Golgi transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 7" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="6 7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR017479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAG03189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="217" mass="23940" checksum="6E656483328505B7" modified="2016-09-07" version="1">MSSSQPGGSGLRYPSNKKTIYDRNLNRSKNAELSRAAFAYLFIEMINLAQKNAKDVGDLEKRLNNQGYPIGVRLLDLLLTRSANPLASIRPTRILPLLQFIAQTLYRHLFGRPADALERSGDDPSQYMLFDNEPMVNTYISLPREMSNLNCAAFVAGIIEGVCDGAGFATEGVTAHSVGAQEEGKEGKAMWPGKTVFLIKFKKEVLEREEILARGSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C8N3</accession>
    <name>A0A177C8N3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">FAD/NAD(P)-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CC84DRAFT_1166068</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG03915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034280.1">
        <property type="nucleotide sequence ID" value="XM_018178867.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C8N3"/>
    <dbReference type="STRING" id="1460663.A0A177C8N3"/>
    <dbReference type="GeneID" id="28762353"/>
    <dbReference type="InParanoid" id="A0A177C8N3"/>
    <dbReference type="OrthoDB" id="655030at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051704">
        <property type="entry name" value="FAD_aromatic-hydroxylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46865:SF2">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46865">
        <property type="entry name" value="OXIDOREDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="4">
        <location>
            <begin position="5"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAG03915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="430" mass="48136" checksum="C89EF0BCEEB3CF82" modified="2016-09-07" version="1">MAPLKILISGGGIAGSCLAWWLYKANVDAQITIIERAPEPRTSGQAVDIRGAAVEVMKAMGLEQAIRDKNTTEVGFEFVYSDGVSKARMAATGDDKNQSFTSEYEILRADLANIFYDATKGMKGIEYVFDETIEDLVQDSQADKVQVKFTNHLPQAYYDLVVGADGQISRTRRLAFGHGPQNGDYLHRLGEYMAFFTIPRNKSDSHWAQWYPATRGRILCTRPSPYNDTRVFMGVVDWDLKRFSEIQDLVKRRDEKGAKNWLAREFEGAGWETQRVLDSMKTTDDFYMQEIVQVKMGEEGFAKGRIALLGDAGYCPSPLSGMGTSLAIVGSYVLAGEIASSPSDIPAALQRYVTTLRPFSDQCQRLMPGMPQALFPQSAWGLKLEAMLVTLLTSPTWQRIGPWVKMLLPKDFQRDKWQLPKQYSGMPVSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C8N9</accession>
    <name>A0A177C8N9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1149818</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG04003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034368.1">
        <property type="nucleotide sequence ID" value="XM_018176683.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C8N9"/>
    <dbReference type="STRING" id="1460663.A0A177C8N9"/>
    <dbReference type="GeneID" id="28760169"/>
    <dbReference type="InParanoid" id="A0A177C8N9"/>
    <dbReference type="OrthoDB" id="5138418at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33303:SF2">
        <property type="entry name" value="COA-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33303">
        <property type="entry name" value="CYTOPLASMIC PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13380">
        <property type="entry name" value="CoA_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00881">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CoA-binding" evidence="1">
        <location>
            <begin position="20"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG04003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="165" mass="17541" checksum="0E27885A47AAE0C4" modified="2016-09-07" version="1">MPQTRGQRRSADMEAALKTFFSASRFAVAGASSDPSKYGHKVFAWYLAHALPVSPLNPRVPTISVGSTTYPTTPSPSALDDAASYSLSIITPPAVTKQVLREAKEAGIQAVWLQPGTFDDEVIEYARREFRAAIGGEGGGGGEGWCVLVDGDEGLRAAGREEARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C8W5</accession>
    <name>A0A177C8W5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1251387</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG03218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033583.1">
        <property type="nucleotide sequence ID" value="XM_018184327.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C8W5"/>
    <dbReference type="GeneID" id="28767813"/>
    <dbReference type="InParanoid" id="A0A177C8W5"/>
    <dbReference type="OrthoDB" id="10463077at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG03218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="235" mass="25490" checksum="788FD216CB68CEE1" modified="2016-09-07" version="1">MREAVGAATTQRFHVSCHTRCDGAASLTGREGGSARRSGCRYRGHTPKAAFCARQSKPGRQCGCHVLACAARDNGIVASRRCPEGVGLELLAARYLACLPCRWTGRRDGPRGSPHSSAVGTLLNHVPCLDRPGRLTNDLSSAKRFSRMRFWKAVNRAHEWAPKRAACFTRRAQGSSNECARRGLDTGDGRVLSLAGRMTGAVVIRRVRAGSLYVVTANVGARDERLFIDACRRVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C9A8</accession>
    <name>A0A177C9A8_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Metalloendopeptidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1217800</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG04334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034699.1">
        <property type="nucleotide sequence ID" value="XM_018182934.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C9A8"/>
    <dbReference type="GeneID" id="28766420"/>
    <dbReference type="InParanoid" id="A0A177C9A8"/>
    <dbReference type="OrthoDB" id="291007at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG04334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="151" mass="16916" checksum="C3F9863965A1FFA6" modified="2016-09-07" version="1">MGFGHEHQRDDRDKHILFNCDKVSGYQQSLDKLMSADRPPPQQLAHNLLCNDWRTALSVGSTIYDFVYGPTQKMFGSFDKDSIMHYGSEGFSDKTLCTPSTPCGCPITTIDGEYIWPKSRVSAGDAEAAREIYPWPGPALPQPKRGINYRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C9K9</accession>
    <name>A0A177C9K9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1164902</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG04434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034799.1">
        <property type="nucleotide sequence ID" value="XM_018178594.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C9K9"/>
    <dbReference type="GeneID" id="28762080"/>
    <dbReference type="InParanoid" id="A0A177C9K9"/>
    <dbReference type="OrthoDB" id="3796908at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG04434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="187" mass="20615" checksum="CB2F622A62408E2B" modified="2016-09-07" version="1" fragment="single">MVLEAYTAYEVGDLEATTFASSSSNNKKNDTEALDATKDEIFFAVMDRWRVGLAEETLKPSYKLIRGVQEFCDIALDVIYYLEEYGFVDGPQMMRKERGDKGVKKSKDKNGGKKAGAGSSSEEDDVSEGSTPKKRSRSSKAHNDSPLKGKGKTKGEVNALQARKKPKTTPKPKASTKKQPKVKKEPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C9S5</accession>
    <name>A0A177C9S5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_857387</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG03528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033893.1">
        <property type="nucleotide sequence ID" value="XM_018187636.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C9S5"/>
    <dbReference type="GeneID" id="28771122"/>
    <dbReference type="InParanoid" id="A0A177C9S5"/>
    <dbReference type="OrthoDB" id="361797at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG03528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="93" mass="10289" checksum="C7BEF7B9CE52DD94" modified="2016-09-07" version="1">MRALRQRKRGTVASSREGSEDRLQAADVHVVLGSVKFIVPREVEVNSLRLIADKTFNVGCQPSRPDIPGLDTLNQSRVLVPPASRSRPTSQRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C9V5</accession>
    <name>A0A177C9V5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1248718</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG03537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033902.1">
        <property type="nucleotide sequence ID" value="XM_018184265.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C9V5"/>
    <dbReference type="GeneID" id="28767751"/>
    <dbReference type="InParanoid" id="A0A177C9V5"/>
    <dbReference type="OrthoDB" id="10474218at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG03537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="262" mass="28139" checksum="83722B7839D3F86C" modified="2016-09-07" version="1">MASFGGIPRRRYDGGRRKGSMAGTACENLLGAAFSQPASGVVSQRCRHMPAAEVIRASLLWQHGGRAQAHGSEHCAAPPAATWSVRQRWRANRPSAGEQTGTHCEQLLNGSGARLAAATHRSSAWCTANPRCVIESLCHHLRASSARPIALADAAGPHAHRPADDAACLFLSRCSAPGVGHWRGGEVCAAPKLTDPALNRRCWVAWLLGQAVLLADYTLHRPRRPFLSNLLCPQEGTLSLSLKAVAGWDVGRFWFHRAVATI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C9W7</accession>
    <name>A0A177C9W7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">TPR repeat protein-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CC84DRAFT_1165792</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the TTC4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG03568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033933.1">
        <property type="nucleotide sequence ID" value="XM_018178798.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C9W7"/>
    <dbReference type="FunCoup" id="A0A177C9W7">
        <property type="interactions" value="1210"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177C9W7"/>
    <dbReference type="GeneID" id="28762284"/>
    <dbReference type="InParanoid" id="A0A177C9W7"/>
    <dbReference type="OrthoDB" id="420195at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051879">
        <property type="term" value="F:Hsp90 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd21381">
        <property type="entry name" value="CTWD_TTC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000611">
        <property type="entry name" value="TPR repeat protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044059">
        <property type="entry name" value="Csn1/TTC4_wheel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46035">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46035:SF1">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18972">
        <property type="entry name" value="Wheel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="Cns1/TTC4 wheel" evidence="4">
        <location>
            <begin position="277"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF18972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAG03568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="393" mass="43480" checksum="CD96B0ACEBFA0FF3" modified="2016-09-07" version="1">MAQPPQADGAPLPSAAMPPAMAEIKSQSVDELIKEMNRMPLFMTTLDETDGEGGQNDALEALKALAYEGTKAEVAENFRQQGNECARAKQWTNAKEFYDKAIAALKAPKKEPDPKDGPPIVDVTDIEIDEEEEAKKEKVIEEACYINRALCNLEKKNYRSCIQDCAATLRLNSSNVKAYYRSATACLSLDKIPEAVDACSLGLAIDPSNAPLKTLHTKISARETHLESIEKARRERKAKVASERATLSLALKSRGIKTRSTEQAPNLEDAEIKLEDKMDPSSILSFPVMLLYPTHAQSDFVKAFAESETLNQHLEYIFPLPWDQKQEFTLNDVEAYMETVAGGLIKLGKKMTLGKVLGSGKCEIKDGLVNISVIPKSKATEWIEEFKKRRGAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CA99</accession>
    <name>A0A177CA99_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1096148</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG03650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034015.1">
        <property type="nucleotide sequence ID" value="XM_018174654.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CA99"/>
    <dbReference type="STRING" id="1460663.A0A177CA99"/>
    <dbReference type="GeneID" id="28758140"/>
    <dbReference type="InParanoid" id="A0A177CA99"/>
    <dbReference type="OrthoDB" id="1393670at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17630">
        <property type="entry name" value="DIENELACTONE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17630:SF80">
        <property type="entry name" value="DIENELACTONE HYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
        <property type="entry name" value="DLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dienelactone hydrolase" evidence="2">
        <location>
            <begin position="238"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG03650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="337" mass="36278" checksum="730CD18EEC090FB4" modified="2016-09-07" version="1">MADNEIATRAPESDAQETPALHVPSPAAPGQSPIPGDSIAQEGPTMGEHCTTDRPTPEGEVPSGELTKLGGVDVYVTKPSDYPHSPSKLLLLLTGGTGIKSTNNQLQADKYAAEGYLVVMPDQFDNDPAPNTVNMAELTKDASWLETIKMKSAEGIKSFMIDMWLARHTPEKVMPILHKVVEGAKEEFADAVANGGGIYGVGYCFGAKYILILAGEHPDTVAWGQEAPKDEEQGTVKKAPVIKAGAIAHGTMVTKEDLEAVKTPMYIVAVKDDPLFPEEEVLTPGRQTLEKNQVEHEVQVFSGVPHGFAVYGDYDDSKIKQAQTQAYGLMLGWIQAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CAJ3</accession>
    <name>A0A177CAJ3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1219023</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG03740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034105.1">
        <property type="nucleotide sequence ID" value="XM_018183049.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CAJ3"/>
    <dbReference type="STRING" id="1460663.A0A177CAJ3"/>
    <dbReference type="GeneID" id="28766535"/>
    <dbReference type="InParanoid" id="A0A177CAJ3"/>
    <dbReference type="OrthoDB" id="271595at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032451">
        <property type="term" value="F:demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070988">
        <property type="term" value="P:demethylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.590">
        <property type="entry name" value="Alpha-ketoglutarate-dependent dioxygenase AlkB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027450">
        <property type="entry name" value="AlkB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037151">
        <property type="entry name" value="AlkB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032857">
        <property type="entry name" value="ALKBH4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12463:SF1">
        <property type="entry name" value="2-OXOGLUTARATE AND FE-DEPENDENT OXYGENASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12463">
        <property type="entry name" value="OXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13532">
        <property type="entry name" value="2OG-FeII_Oxy_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="1">
        <location>
            <begin position="180"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG03740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="335" mass="39025" checksum="D072327D59038F85" modified="2016-09-07" version="1">MHRMALSKDYHNERIILKSKQEEHINPVQHHAAIETLYQEHAKAIFDPQIYLQIHINYDEEEKLKRRKPNIADATNRRISTSPIKAIRKRKESGYSSNMEEVPIQPRGLFWQNDFITHEHEARLIQIFQNELEWPERSGRLSLHYGYTFDYKTFGVDPNVPFKEFPEWLVPLIPTREGRPPDQVCLQHYPPGAGIPPHVDTHSAYDQLYALSLGAPVMMQFARSSDTGPDGDSEQKEVVEVDLTPRSMMQMSGDSRLHWTHGIKKRKTDTLRDGTVRRRDDRWSITYRWVREPAVCNCGNTKLCDTAQQQLGIERELRWKKAGEGTTVGLLQKFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CAU6</accession>
    <name>A0A177CAU6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sulfite oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CC84DRAFT_793388</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mo-molybdopterin</name>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG04466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034831.1">
        <property type="nucleotide sequence ID" value="XM_018187421.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CAU6"/>
    <dbReference type="STRING" id="1460663.A0A177CAU6"/>
    <dbReference type="GeneID" id="28770907"/>
    <dbReference type="InParanoid" id="A0A177CAU6"/>
    <dbReference type="OrthoDB" id="10051395at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030151">
        <property type="term" value="F:molybdenum ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043546">
        <property type="term" value="F:molybdopterin cofactor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008482">
        <property type="term" value="F:sulfite oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006790">
        <property type="term" value="P:sulfur compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.420.10:FF:000002">
        <property type="entry name" value="sulfite oxidase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.650">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.420.10">
        <property type="entry name" value="Oxidoreductase, molybdopterin-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005066">
        <property type="entry name" value="MoCF_OxRdtse_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008335">
        <property type="entry name" value="Mopterin_OxRdtase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000572">
        <property type="entry name" value="OxRdtase_Mopterin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036374">
        <property type="entry name" value="OxRdtase_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19372:SF7">
        <property type="entry name" value="SULFITE OXIDASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19372">
        <property type="entry name" value="SULFITE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03404">
        <property type="entry name" value="Mo-co_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00174">
        <property type="entry name" value="Oxidored_molyb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00407">
        <property type="entry name" value="EUMOPTERIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56524">
        <property type="entry name" value="Oxidoreductase molybdopterin-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidoreductase molybdopterin-binding" evidence="5">
        <location>
            <begin position="42"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="Moybdenum cofactor oxidoreductase dimerisation" evidence="6">
        <location>
            <begin position="249"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAG04466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="378" mass="41989" checksum="4537D8197C989508" modified="2016-09-07" version="1">MARADSTKYEYSVEEPLNREPELEELVSSFLTKEGKGYDRNHGPIPHIDKEEHKVKVNGLVKKELNLSIGELEKLPQKSIICALQCAGNRRHTMRTKLKEVSGIDWFDGAVMNCSWTGPLLRDVLTSASLNVPESSYATTHVAFACFQTPTQEDEWYGASVPLSRVMDPESGIILALQMNGKPLSPNHGAPVRVVTPGIAGARSVKWLDRVTVQTCESDNFYQRHDYKILPPEATCKEEAEKWWDRVSALQDMPINSVIAIPASSSTIHLSPDGTTEVKGYALPSGSDGPITKVEISTDDGETWQLAELLEDQETDGAELKWAWSLWRARVKFEKGHGRKVLSRATDTSGNTQVKCPEWNLRGVAYNGYGEASDLYVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CB71</accession>
    <name>A0A177CB71_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Amidase signature enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_883628</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG04027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034392.1">
        <property type="nucleotide sequence ID" value="XM_018187777.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CB71"/>
    <dbReference type="STRING" id="1460663.A0A177CB71"/>
    <dbReference type="GeneID" id="28771263"/>
    <dbReference type="InParanoid" id="A0A177CB71"/>
    <dbReference type="OrthoDB" id="566138at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42678">
        <property type="entry name" value="AMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42678:SF37">
        <property type="entry name" value="AMIDASE C869.01-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008058040" evidence="1">
        <location>
            <begin position="22"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="domain" description="Amidase" evidence="2">
        <location>
            <begin position="84"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG04027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="590" mass="63595" checksum="2E691C033003F232" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CBP6</accession>
    <name>A0A177CBP6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_801624</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0057 (PMP3) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG04756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035121.1">
        <property type="nucleotide sequence ID" value="XM_018187476.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CBP6"/>
    <dbReference type="GeneID" id="28770962"/>
    <dbReference type="InParanoid" id="A0A177CBP6"/>
    <dbReference type="OrthoDB" id="2152119at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000612">
        <property type="entry name" value="PMP3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21659">
        <property type="entry name" value="HYDROPHOBIC PROTEIN RCI2 LOW TEMPERATURE AND SALT RESPONSIVE PROTEIN LTI6 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21659:SF42">
        <property type="entry name" value="UPF0057 MEMBRANE PROTEIN ZK632.10-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01679">
        <property type="entry name" value="Pmp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01309">
        <property type="entry name" value="UPF0057"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008058069" evidence="7">
        <location>
            <begin position="24"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="39"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAG04756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="121" mass="13106" checksum="E0BB87F42FDE0279" modified="2016-09-07" version="1">MGAIKLVLLILATIFFPPIGVFAVAGCGADFFINICLTILGYIPGHIHAFYLIYVFYERKDEVKNGVYNPRPASGIFSERVLRGGRHVPAAVQVQQPVAQPNSVPQPQPGQVLPAQAYGTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CC22</accession>
    <name>A0A177CC22_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CC84DRAFT_1197084</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG05203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035568.1">
        <property type="nucleotide sequence ID" value="XM_018181502.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CC22"/>
    <dbReference type="STRING" id="1460663.A0A177CC22"/>
    <dbReference type="GeneID" id="28764988"/>
    <dbReference type="InParanoid" id="A0A177CC22"/>
    <dbReference type="OrthoDB" id="5296287at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF33">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="28"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="155"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="185"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="260"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="299"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="340"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="365"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="395"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="433"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="30"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAG05203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="467" mass="51424" checksum="B414F7CE8C20A768" modified="2016-09-07" version="1">MDLENGLVGWDSADDPENPQNWPWRKKWTLMLLIASICTFSPMASSLCAPGTSLTLAEFNTDDKTIGSLMISIFVLGYAVGPLFLAPLSELYGRTLVINVSSAFFNAFILGCSFAPNMSSLIVMRLLAGIGGSACMTIVSAIIGDVFKVHERAAASAIVVGTPSLAPIIGPIAGGFISQYLGWRWAYWILLMGSGPLNIAMIFCMRESNHPTILSRKTIRLRKSLHRPDLRSHLEIHLPPRQLLARSIVRPAKFLFRSPIAFLISLYVSIVYGTLYLLFTTIPDVFQNTYDFEIQYTGLAYLGLGLGMFLALALVVKFNDRTVLRLRNKNGGVFEPEMRLATTPYFAPFMPASLLLYAWTARSSVHWIVPCLSFIPYGFGLLGIFVPCQTYMVDAFLSTAASAVAALVCLRCIFGAVLPLVGPVMYARLGLGWGNTVLGLITVAVTPVPFAFLRWGGWVRRRWPVEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CC44</accession>
    <name>A0A177CC44_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1177308</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG05225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035590.1">
        <property type="nucleotide sequence ID" value="XM_018180276.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CC44"/>
    <dbReference type="GeneID" id="28763762"/>
    <dbReference type="InParanoid" id="A0A177CC44"/>
    <dbReference type="OrthoDB" id="3426753at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008058092" evidence="2">
        <location>
            <begin position="19"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG05225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="234" mass="25060" checksum="9799A80BD217BA32" modified="2016-09-07" version="1">MLNPSLAVAVTLPLVISAKPVVAHTSIDDPVFNAPVLTHFLHMNALTSFPVNISDIDGIRGRYPNVGGNLTGAITGTIVNMGAATEWFPILLNETASFYTNIWTINATVPSLTQSKPISVPKQNRKQRPGQYGARPGDNTPSPPSSSPANEYTTIYLTASAHLTYANEFLHGFGPVTVSSSHPAFLDLNVRSFYAEIEAGYRTGLGRIDVFEVKTEGKRDGSPIEALLPPGVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CC55</accession>
    <name>A0A177CC55_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="4">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CC84DRAFT_1093326</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4"/>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG04771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035136.1">
        <property type="nucleotide sequence ID" value="XM_018174508.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CC55"/>
    <dbReference type="STRING" id="1460663.A0A177CC55"/>
    <dbReference type="GeneID" id="28757994"/>
    <dbReference type="InParanoid" id="A0A177CC55"/>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06609">
        <property type="entry name" value="STKc_MST3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000411">
        <property type="entry name" value="Probable Ste20-like kinase Don3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050629">
        <property type="entry name" value="STE20/SPS1-PAK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012:SF18">
        <property type="entry name" value="HAPPYHOUR, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012">
        <property type="entry name" value="STERILE20-LIKE KINASE, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11 19" id="KW-0418">Kinase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="18">
        <location>
            <begin position="5"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="354"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="553"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="614"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="561"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="617"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="OAG04771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="707" mass="77578" checksum="E245C5177C574308" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CCX8</accession>
    <name>A0A177CCX8_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">RNA-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CC84DRAFT_1094374</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG04628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034993.1">
        <property type="nucleotide sequence ID" value="XM_018174560.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CCX8"/>
    <dbReference type="FunCoup" id="A0A177CCX8">
        <property type="interactions" value="135"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CCX8"/>
    <dbReference type="GeneID" id="28758046"/>
    <dbReference type="InParanoid" id="A0A177CCX8"/>
    <dbReference type="OrthoDB" id="448399at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140453">
        <property type="term" value="C:protein aggregate center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071502">
        <property type="term" value="P:cellular response to temperature stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031445">
        <property type="term" value="P:regulation of heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd06133">
        <property type="entry name" value="ERI-1_3'hExo_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12452">
        <property type="entry name" value="RRM_ARP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1060.10:FF:000021">
        <property type="entry name" value="MUTL protein homolog 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1060.10:FF:000024">
        <property type="entry name" value="RNA-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1060.10">
        <property type="entry name" value="Zinc finger, RanBP2-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047201">
        <property type="entry name" value="ERI-1_3'hExo-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034351">
        <property type="entry name" value="Nrp1_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001876">
        <property type="entry name" value="Znf_RanBP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036443">
        <property type="entry name" value="Znf_RanBP2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23111:SF40">
        <property type="entry name" value="RNA-BINDING PROTEIN INVOLVED IN HETEROCHROMATIN ASSEMBLY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23111">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00641">
        <property type="entry name" value="Zn_ribbon_RanBP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00547">
        <property type="entry name" value="ZnF_RBZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90209">
        <property type="entry name" value="Ran binding protein zinc finger-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01358">
        <property type="entry name" value="ZF_RANBP2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50199">
        <property type="entry name" value="ZF_RANBP2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="9 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RRM" evidence="14">
        <location>
            <begin position="253"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="RanBP2-type" evidence="15">
        <location>
            <begin position="352"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="domain" description="RanBP2-type" evidence="15">
        <location>
            <begin position="435"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="545"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="603"/>
            <end position="612"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OAG04628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="18">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="612" mass="65581" checksum="F52E4573659BC83D" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2023-06-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CD40</accession>
    <name>A0A177CD40_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1177210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG05111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035476.1">
        <property type="nucleotide sequence ID" value="XM_018180273.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CD40"/>
    <dbReference type="GeneID" id="28763759"/>
    <dbReference type="InParanoid" id="A0A177CD40"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG05111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="222" mass="23789" checksum="28FDFB0DE1F9F14E" modified="2016-09-07" version="1">MRRAVERSSAPFQARKAPPPLLSPTSPADSSVITAGGTGGTDVLRERVPEQATRPETLLQSVARDHGPARGSDSGLWMCEPGSAVSAGAVRLTTICATQGREDWGWPNFIPRSSALYRETPEAQYRGRTKGAYRLDRIPRSVSRQYSPNKNGPRDVAPRRSSAIPGVPRACSGMIWEPVPLGDAPNLWKAGRHLLSSSNGCNSSACVARIGQVITIRPVIPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CEN3</accession>
    <name>A0A177CEN3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_1122344</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG05238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035603.1">
        <property type="nucleotide sequence ID" value="XM_018175633.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CEN3"/>
    <dbReference type="FunCoup" id="A0A177CEN3">
        <property type="interactions" value="141"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CEN3"/>
    <dbReference type="GeneID" id="28759119"/>
    <dbReference type="InParanoid" id="A0A177CEN3"/>
    <dbReference type="OrthoDB" id="294295at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000398">
        <property type="entry name" value="Probable 2-deoxy-D-gluconate 3-dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760:SF5">
        <property type="entry name" value="2-DEHYDRO-3-DEOXY-D-GLUCONATE 5-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASES/REDUCTASES FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAG05238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="264" mass="28136" checksum="6D75C32D18CFF7AC" modified="2016-09-07" version="1">MTNVKDLFSLEGQTALVTGGTRGIGQSMAIALAEAGADILLVQRDTSNQSTKQEIEKLGRKVTIYTADLSSAESVSALLPKILKDGHRIHILLNCGGIQKRHPAHQFPDDDWQSVLQVNLTSVFTLCRDVGAHMLQQPTDLAPNSTRRGAIINIASLLSFQGGLTVPAYAASKGGVAQLTKALSNEWASKGINVNAIAPGYIATEMNTALMQDEKRAKSILERIPAGRWGSPEDFKGAVVWLASPASAYVSGEVVTVDGGWMGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CES2</accession>
    <name>A0A177CES2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_749982</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG06123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036488.1">
        <property type="nucleotide sequence ID" value="XM_018187288.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CES2"/>
    <dbReference type="GeneID" id="28770774"/>
    <dbReference type="InParanoid" id="A0A177CES2"/>
    <dbReference type="OrthoDB" id="3789664at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="402"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="183"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="220"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG06123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="549" mass="60721" checksum="BE6B100D482E8D05" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CES8</accession>
    <name>A0A177CES8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NRPS-like enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CC84DRAFT_833323</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the NRP synthetase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG05257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035622.1">
        <property type="nucleotide sequence ID" value="XM_018187577.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CES8"/>
    <dbReference type="STRING" id="1460663.A0A177CES8"/>
    <dbReference type="GeneID" id="28771063"/>
    <dbReference type="InParanoid" id="A0A177CES8"/>
    <dbReference type="OrthoDB" id="429813at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051414">
        <property type="entry name" value="Adenylate-forming_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43439:SF2">
        <property type="entry name" value="ENZYME, PUTATIVE (JCVI)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43439">
        <property type="entry name" value="PHENYLACETATE-COENZYME A LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23562">
        <property type="entry name" value="AMP-binding_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="4">
        <location>
            <begin position="564"/>
            <end position="640"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00029454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAG05257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="1086" mass="119356" checksum="EA5A29CEEA8FA55D" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CEW7</accession>
    <name>A0A177CEW7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">MFS monocarboxylate transporter-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CC84DRAFT_1187160</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG06164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036529.1">
        <property type="nucleotide sequence ID" value="XM_018180907.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CEW7"/>
    <dbReference type="FunCoup" id="A0A177CEW7">
        <property type="interactions" value="179"/>
    </dbReference>
    <dbReference type="GeneID" id="28764393"/>
    <dbReference type="InParanoid" id="A0A177CEW7"/>
    <dbReference type="OrthoDB" id="410267at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF177">
        <property type="entry name" value="RIBOFLAVIN TRANSPORTER MCH5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="21"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="94"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="122"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="151"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="182"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="223"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="290"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="315"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="354"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="379"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="4">
        <location>
            <begin position="223"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAG06164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="415" mass="44127" checksum="4F674C1B30AB9EC3" modified="2016-09-07" version="1">MEQAQESTPIYQAYPEGGLKAYSVVLGAWFTLLPASGLLNSTGILQAWLFEHYLIDYTESEISWIFSTFAFLFFFGGFIVAVGPLFDRYGAKRLLPVGALGLVASLVATSWCRLYYQFILSFGGLGGCACSVLWTTSIATLGHWFDQNRGLATGIATTAGGVGGVLFPIVFTQLVGRIGFTWTMNCFALISAFCLVVGVALLKTRLPRSPHASLIMDWRGFKDFRFVLTMSAIFVLDWAVLVPPAYISTYASSKGLHSLSQHVLAILNAASILGRGLPGPIADRIGRFNVMILSSAACTASILGLWLNANSSRAILSAFAVLYGLFSGSVYSLTPVCVAQLCRSDDYASKYGTAYGVVSFATLAGVPVSGSIVDVGGGANYAALISFCGAAYAASTVLFVVARGCSIGWGLQAKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CF80</accession>
    <name>A0A177CF80_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_721999</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG05417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035782.1">
        <property type="nucleotide sequence ID" value="XM_018187168.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CF80"/>
    <dbReference type="GeneID" id="28770654"/>
    <dbReference type="InParanoid" id="A0A177CF80"/>
    <dbReference type="OrthoDB" id="3785436at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="377"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG05417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="433" mass="47100" checksum="DA54963DD7292E19" modified="2016-09-07" version="1" fragment="single">MKGAQFAVILVGILFTLGGAFSFFPHFGHRSNDMMQVDSSAVSTFEGVEGVGLQHLEARRSRGSRTSRKRPARPARKRPAKKKTTKKKKTPKKTTKKKGTKKPTKTKKCTAAMKKAGKCKTTAKCTAAMKKAGKCKTATKCTAAMKKAGKCPATPTKSHAPTSTSAAACKFSPKPKAGTAGAKGGKVNKKLQARIDPDPCRPADENDKIMIENFKIAQRAARKKGETLKDKRMYLFLVKQGPTVGAKHHAVVVGKVMKVGNQLGMEATMQQLGKPTDQNGNAVRHPNAKVFCGSAVGGVCNTGPYRRIECGRMQGKYKFVSGAAVEFADPEHFIQKGEEVFMAEKPYNVLTWNCQIYAKKLINVTKLQPGQIVELTNEQAKPSRPQGTWSDSDSDWDSDDGMWNGGMGGFRVINADPEPFDPNTNNGDRFEID</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CFS0</accession>
    <name>A0A177CFS0_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Subtelomeric hrmA-associated cluster protein AFUB-079030/YDR124W-like helical bundle domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1259057</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG05658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036023.1">
        <property type="nucleotide sequence ID" value="XM_018184877.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CFS0"/>
    <dbReference type="STRING" id="1460663.A0A177CFS0"/>
    <dbReference type="GeneID" id="28768363"/>
    <dbReference type="InParanoid" id="A0A177CFS0"/>
    <dbReference type="OrthoDB" id="5338458at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047092">
        <property type="entry name" value="AFUB_07903/YDR124W-like_hel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021264">
        <property type="entry name" value="AFUB_079030/YDR124W-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36102">
        <property type="entry name" value="CHROMOSOME 10, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36102:SF1">
        <property type="entry name" value="YDR124W-LIKE HELICAL BUNDLE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11001">
        <property type="entry name" value="AFUB_07903_YDR124W_hel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Subtelomeric hrmA-associated cluster protein AFUB-079030/YDR124W-like helical bundle" evidence="2">
        <location>
            <begin position="169"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="378"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="104"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="378"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="394"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG05658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="603" mass="67270" checksum="E12A31E8E0B26DE0" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CG29</accession>
    <name>A0A177CG29_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_753988</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG06181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036546.1">
        <property type="nucleotide sequence ID" value="XM_018187306.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CG29"/>
    <dbReference type="GeneID" id="28770792"/>
    <dbReference type="InParanoid" id="A0A177CG29"/>
    <dbReference type="OrthoDB" id="10428016at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008058158" evidence="1">
        <location>
            <begin position="19"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG06181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="92" mass="10190" checksum="CFA7C5E442F8D676" modified="2016-09-07" version="1">MKPIRIITTFTQVIFVSASGGTKDPKPPHTPTYTPYTYTTSLCTPTATQPYTVTNTWYETSIAYTPHKSTWTWGSELYDCTTGLATTSILVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CGI1</accession>
    <name>A0A177CGI1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_741112</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG05938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036303.1">
        <property type="nucleotide sequence ID" value="XM_018187258.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CGI1"/>
    <dbReference type="GeneID" id="28770744"/>
    <dbReference type="InParanoid" id="A0A177CGI1"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG05938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="154" mass="17674" checksum="E67DB5C7B94B576E" modified="2016-09-07" version="1">MKLRGRQLMLLAFGVFFVDLVNTTILLRAFFDKMYQANLTRLILHRCRFLNSYRLDHSLAFIPCIFRFDTSQPSQARFQYDLVGYGILLAHLIVLLETDRLPRCVNCIERPRHAADRQPDLVLDDGRAGADAPDRTEHPGVTLIEFGGVRRGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CGR5</accession>
    <name>A0A177CGR5_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SRR1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_786154</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG06536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036901.1">
        <property type="nucleotide sequence ID" value="XM_018187378.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CGR5"/>
    <dbReference type="GeneID" id="28770864"/>
    <dbReference type="InParanoid" id="A0A177CGR5"/>
    <dbReference type="OrthoDB" id="5230585at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012942">
        <property type="entry name" value="SRR1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42080">
        <property type="entry name" value="SRR1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42080:SF1">
        <property type="entry name" value="SRR1-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07985">
        <property type="entry name" value="SRR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SRR1-like" evidence="1">
        <location>
            <begin position="22"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG06536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="110" mass="12369" checksum="0B628E19C9483E74" modified="2016-09-07" version="1">MALWDDSVEQKYVFRSLRKMVLSNAAQITNIICIGHGSLRRSPDSMMQHIAVGSIAKELSRLYEELGKPLQEQITILAQDPSYTENDKDLLARLPVPVYACLFAMVLMAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CH03</accession>
    <name>A0A177CH03_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cullin-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CC84DRAFT_1164471</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11 12">Belongs to the cullin family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG06129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036494.1">
        <property type="nucleotide sequence ID" value="XM_018178492.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CH03"/>
    <dbReference type="FunCoup" id="A0A177CH03">
        <property type="interactions" value="1022"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CH03"/>
    <dbReference type="GeneID" id="28761978"/>
    <dbReference type="InParanoid" id="A0A177CH03"/>
    <dbReference type="OrthoDB" id="27073at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902531">
        <property type="term" value="P:regulation of intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000014">
        <property type="entry name" value="Cullin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000007">
        <property type="entry name" value="Cullin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000011">
        <property type="entry name" value="Cullin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000026">
        <property type="entry name" value="Cullin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.130:FF:000003">
        <property type="entry name" value="Cullin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000029">
        <property type="entry name" value="Cullin homolog 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1310.10">
        <property type="entry name" value="Cullin Repeats"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1030.10">
        <property type="entry name" value="Ring Box Chain A, domain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045093">
        <property type="entry name" value="Cullin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059120">
        <property type="entry name" value="Cullin-like_AB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016157">
        <property type="entry name" value="Cullin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016158">
        <property type="entry name" value="Cullin_homology"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036317">
        <property type="entry name" value="Cullin_homology_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001373">
        <property type="entry name" value="Cullin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019559">
        <property type="entry name" value="Cullin_neddylation_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11932">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00888">
        <property type="entry name" value="Cullin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26557">
        <property type="entry name" value="Cullin_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10557">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00182">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00884">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75632">
        <property type="entry name" value="Cullin homology domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01256">
        <property type="entry name" value="CULLIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50069">
        <property type="entry name" value="CULLIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Cullin family profile" evidence="13">
        <location>
            <begin position="405"/>
            <end position="644"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00069612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OAG06129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="769" mass="88763" checksum="DD45B254BEC51CBF" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2023-06-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CHW3</accession>
    <name>A0A177CHW3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_635170</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG07113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037478.1">
        <property type="nucleotide sequence ID" value="XM_018186975.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CHW3"/>
    <dbReference type="GeneID" id="28770461"/>
    <dbReference type="InParanoid" id="A0A177CHW3"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG07113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="126" mass="13929" checksum="615EA4AF6464130F" modified="2016-09-07" version="1">MKGERSRPCDSTCTSACGALSCDTVSIFRKWLEVRTDLLGSFVRLAKSAAQNSQAEAMLQSNLLSDRCPHSGGGQWLHSRFVASTIPRHVQQQLKVGNYGDLHAMQYAICNGQTLCSLWRGLRERA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CJ17</accession>
    <name>A0A177CJ17_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RGS-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CC84DRAFT_665451</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG07524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037889.1">
        <property type="nucleotide sequence ID" value="XM_018187063.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CJ17"/>
    <dbReference type="FunCoup" id="A0A177CJ17">
        <property type="interactions" value="108"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CJ17"/>
    <dbReference type="GeneID" id="28770549"/>
    <dbReference type="InParanoid" id="A0A177CJ17"/>
    <dbReference type="OrthoDB" id="196547at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009968">
        <property type="term" value="P:negative regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04450">
        <property type="entry name" value="DEP_RGS7-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08708">
        <property type="entry name" value="RGS_FLBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000591">
        <property type="entry name" value="DEP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016137">
        <property type="entry name" value="RGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058855">
        <property type="entry name" value="RGS1/SST2-like_Fungal-DR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10845:SF192">
        <property type="entry name" value="DOUBLE HIT, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10845">
        <property type="entry name" value="REGULATOR OF G PROTEIN SIGNALING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00610">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00615">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25889">
        <property type="entry name" value="WHD_Fungal_DR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01301">
        <property type="entry name" value="RGSPROTEIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00049">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00315">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50186">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50132">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0734">Signal transduction inhibitor</keyword>
    <feature type="domain" description="DEP" evidence="4">
        <location>
            <begin position="424"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="domain" description="RGS" evidence="3">
        <location>
            <begin position="523"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="40"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="75"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="96"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="132"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="151"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAG07524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="686" mass="75382" checksum="D9362ED6F099A0D5" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CJ70</accession>
    <name>A0A177CJ70_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zinc knuckle-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1163711</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG07584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037949.1">
        <property type="nucleotide sequence ID" value="XM_018178323.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CJ70"/>
    <dbReference type="GeneID" id="28761809"/>
    <dbReference type="InParanoid" id="A0A177CJ70"/>
    <dbReference type="OrthoDB" id="437973at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13917">
        <property type="entry name" value="zf-CCHC_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="99"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="244"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="270"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="286"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="317"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="329"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG07584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="361" mass="40913" checksum="CB38E686C603AAEB" modified="2016-09-07" version="1">MFSRRGGYGGRSKATPTTTCQKCLQKGHYSYECTVSAQERPYKPRPSRTQQLLNPSLKPKLTEEVPSDLLRSKKGLADTILAEKEEQRRKTSGRRSRSRSASSVSDSDSVSTISTNRSRSPSPKRIKDGSASLRGGDTLRKRGRRSVSSGSNHSLDRTERNTRRRLSSMSPEQRGRRRSRSRSSPMDISHDEGLRRQAPRTHHSPGGSYTRGRGGRRSRSRSKRTPVKPSSRRSLSRSPSRSPNRLDRMDTSDDRPHPQNGRSPIGRPVRNSRSRSRSPYRRRSRSPYSKRPMSRSPSPYKSRNGGMDGRSARSGRHRFDTEVRHPEPVRAPPPQPAPPRERSLSPYSKRVALTQQMQGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CJY4</accession>
    <name>A0A177CJY4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">p-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1088921</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG07282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037647.1">
        <property type="nucleotide sequence ID" value="XM_018174280.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CJY4"/>
    <dbReference type="STRING" id="1460663.A0A177CJY4"/>
    <dbReference type="GeneID" id="28757766"/>
    <dbReference type="InParanoid" id="A0A177CJY4"/>
    <dbReference type="OrthoDB" id="10042665at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19481">
        <property type="entry name" value="RecA-like_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054289">
        <property type="entry name" value="DUF7025"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46411:SF3">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46411">
        <property type="entry name" value="FAMILY ATPASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22942">
        <property type="entry name" value="DUF7025"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="2">
        <location>
            <begin position="468"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="28"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG07282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="672" mass="75170" checksum="007395EF888ECF90" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CJZ9</accession>
    <name>A0A177CJZ9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF1761-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1163758</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG07636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038001.1">
        <property type="nucleotide sequence ID" value="XM_018178330.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CJZ9"/>
    <dbReference type="GeneID" id="28761816"/>
    <dbReference type="InParanoid" id="A0A177CJZ9"/>
    <dbReference type="OrthoDB" id="2344991at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013879">
        <property type="entry name" value="DUF1761"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40638">
        <property type="entry name" value="UPF0591 MEMBRANE PROTEIN C15E1.02C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40638:SF1">
        <property type="entry name" value="UPF0591 MEMBRANE PROTEIN C15E1.02C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08570">
        <property type="entry name" value="DUF1761"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="14"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG07636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="151" mass="15744" checksum="CAD3F3AF3B3235E7" modified="2016-09-07" version="1">MATLHYLPPVKPSAIALGTAFNHAISLAVLGPVFGDSYRRAQAANSKEEFFHSKEAATAAASWGSSLAGSAIQAYGVGALINATGTLTYKGAAYLGSLIFFASAAPSVVSQVLTEKRPLDTIAVGALARVFETVGLSLFLTYWGTRTNPFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CKH5</accession>
    <name>A0A177CKH5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">SPX-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CC84DRAFT_1163508</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG07297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037662.1">
        <property type="nucleotide sequence ID" value="XM_018178280.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CKH5"/>
    <dbReference type="GeneID" id="28761766"/>
    <dbReference type="InParanoid" id="A0A177CKH5"/>
    <dbReference type="OrthoDB" id="5588846at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033254">
        <property type="term" value="C:vacuolar transporter chaperone complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016237">
        <property type="term" value="P:microautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006799">
        <property type="term" value="P:polyphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042144">
        <property type="term" value="P:vacuole fusion, non-autophagic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14474">
        <property type="entry name" value="SPX_YDR089W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.100.30">
        <property type="entry name" value="VTC, catalytic tunnel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004331">
        <property type="entry name" value="SPX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051572">
        <property type="entry name" value="VTC_Complex_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018966">
        <property type="entry name" value="VTC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042267">
        <property type="entry name" value="VTC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46140">
        <property type="entry name" value="VACUOLAR TRANSPORTER CHAPERONE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46140:SF1">
        <property type="entry name" value="VACUOLAR TRANSPORTER CHAPERONE COMPLEX SUBUNIT 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09359">
        <property type="entry name" value="VTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51382">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="758"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="792"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="825"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="domain" description="SPX" evidence="9">
        <location>
            <begin position="1"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="540"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="670"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="725"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="552"/>
            <end position="587"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAG07297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="849" mass="94381" checksum="C51CA224F6631CC7" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CKK3</accession>
    <name>A0A177CKK3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1216341</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG07370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037735.1">
        <property type="nucleotide sequence ID" value="XM_018182790.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CKK3"/>
    <dbReference type="GeneID" id="28766276"/>
    <dbReference type="InParanoid" id="A0A177CKK3"/>
    <dbReference type="OrthoDB" id="10455670at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG07370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="83" mass="9302" checksum="1D2F2F5CAA63BDC4" modified="2016-09-07" version="1">MTTTIAYPITTASPPPPPGPPPATPPPPPPYPPRPPPLSRQQEREGLLRHANRFCNDWADRCRGLPPLERICLNRILELCRHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CKM2</accession>
    <name>A0A177CKM2_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">MFS general substrate transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_1089314</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG07781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038146.1">
        <property type="nucleotide sequence ID" value="XM_018174298.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CKM2"/>
    <dbReference type="STRING" id="1460663.A0A177CKM2"/>
    <dbReference type="GeneID" id="28757784"/>
    <dbReference type="InParanoid" id="A0A177CKM2"/>
    <dbReference type="OrthoDB" id="10250282at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF76">
        <property type="entry name" value="POLYAMINE TRANSPORT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="416"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="452"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="482"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="512"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="569"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="601"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="683"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="715"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="768"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="796"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="857"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="889"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="243"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="120"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="246"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="305"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="345"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAG07781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1005" mass="112941" checksum="F9AF5AD90EA45092" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CLF7</accession>
    <name>A0A177CLF7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HET-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1203553</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038436.1">
        <property type="nucleotide sequence ID" value="XM_018181840.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CLF7"/>
    <dbReference type="STRING" id="1460663.A0A177CLF7"/>
    <dbReference type="GeneID" id="28765326"/>
    <dbReference type="InParanoid" id="A0A177CLF7"/>
    <dbReference type="OrthoDB" id="2958217at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF10">
        <property type="entry name" value="TOL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="205"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG08071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="684" mass="79127" checksum="55BCE8EF4083950F" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CLM4</accession>
    <name>A0A177CLM4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1162387</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038800.1">
        <property type="nucleotide sequence ID" value="XM_018177979.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CLM4"/>
    <dbReference type="GeneID" id="28761465"/>
    <dbReference type="InParanoid" id="A0A177CLM4"/>
    <dbReference type="OrthoDB" id="3772124at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG08435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="131" mass="14630" checksum="71891B589D7530EC" modified="2016-09-07" version="1">MDDFPRSTVAVRELSHTSQGSSITNPHHAPPSPSLSKASTESSRHSCEAPRSPSVTHKRETENLTSFPSPSDFKPTTAFDPDAPQPYREEDFQGKSKDEVRRMRKRDYAVEISRLMGRQLVKGMSGKGEDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CLN3</accession>
    <name>A0A177CLN3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">FAD/NAD(P)-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CC84DRAFT_1140183</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG07852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038217.1">
        <property type="nucleotide sequence ID" value="XM_018176276.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CLN3"/>
    <dbReference type="STRING" id="1460663.A0A177CLN3"/>
    <dbReference type="GeneID" id="28759762"/>
    <dbReference type="InParanoid" id="A0A177CLN3"/>
    <dbReference type="OrthoDB" id="47494at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47178:SF6">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47178">
        <property type="entry name" value="MONOOXYGENASE, FAD-BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="114"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAG07852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="389" mass="42895" checksum="4A1777915BAD4946" modified="2016-09-07" version="1">MASPHVLIIGAGMSGLTLAQQLRKNGIPFTVFERDAHRDARGQGWALSLFGEAYGLMKTLMPADLGPVEQTSHLLPLNLPPQFSFYDITRPEFRVGVIADDDLKVVRANRRRMRDWLEQGIDVQFNKRLVRVEEYGDKVTAHFEDGTSATGDFLVGAEGTRSVVRKHILKGQDVMRPLPIGSIFGEIELSGDDFSQQLTLSHSNYIVMDPRLATEEQTAIFCALNRVSPDGKTGYYYFILLWVDQDAPKHAGEKRWTELASQEQLAAYAREKTKGYPDKLRALVDKIPTERYNTPGFQLQGVDLDPEQLPAGRVLLIGDAAHSMAPCEGLKDLVSGFNADMIARGKAASSVSNGVLEAYGDEAKFITFGREAGLMPPKPVSLSEVSIVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CNH2</accession>
    <name>A0A177CNH2_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Calcium permease family membrane transporter-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CC84DRAFT_1162397</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038815.1">
        <property type="nucleotide sequence ID" value="XM_018177985.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CNH2"/>
    <dbReference type="FunCoup" id="A0A177CNH2">
        <property type="interactions" value="14"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CNH2"/>
    <dbReference type="GeneID" id="28761471"/>
    <dbReference type="InParanoid" id="A0A177CNH2"/>
    <dbReference type="OrthoDB" id="16982at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990816">
        <property type="term" value="C:vacuole-mitochondrion membrane contact site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015369">
        <property type="term" value="F:calcium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015386">
        <property type="term" value="F:potassium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015385">
        <property type="term" value="F:sodium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1420.30:FF:000017">
        <property type="entry name" value="Calcium permease family membrane transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="entry name" value="NCX, central ion-binding region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004713">
        <property type="entry name" value="CaH_exchang"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005185">
        <property type="entry name" value="YccF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503">
        <property type="entry name" value="VACUOLAR CALCIUM ION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503:SF10">
        <property type="entry name" value="VNX1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03733">
        <property type="entry name" value="YccF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="282"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="431"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="457"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="522"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="555"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="586"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="620"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="654"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="724"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="942"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="974"/>
            <end position="998"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1010"/>
            <end position="1029"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1049"/>
            <end position="1068"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1080"/>
            <end position="1097"/>
        </location>
    </feature>
    <feature type="domain" description="Inner membrane component" evidence="11">
        <location>
            <begin position="285"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="10">
        <location>
            <begin position="556"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="10">
        <location>
            <begin position="942"/>
            <end position="1093"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="812"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="12"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="73"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="108"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="123"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="148"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="203"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OAG08450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1138" mass="124962" checksum="1F7CB846C61596DE" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CNP1</accession>
    <name>A0A177CNP1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cation efflux family protein family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_1086033</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038742.1">
        <property type="nucleotide sequence ID" value="XM_018174135.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CNP1"/>
    <dbReference type="FunCoup" id="A0A177CNP1">
        <property type="interactions" value="26"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CNP1"/>
    <dbReference type="GeneID" id="28757621"/>
    <dbReference type="InParanoid" id="A0A177CNP1"/>
    <dbReference type="OrthoDB" id="5382797at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098771">
        <property type="term" value="P:inorganic ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030003">
        <property type="term" value="P:intracellular monoatomic cation homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="141"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="172"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="211"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="305"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="332"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="7">
        <location>
            <begin position="150"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="21"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAG08377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="445" mass="48270" checksum="A8D4D66F8C4E121B" modified="2016-09-07" version="1">MDALSPMSATFPSERYGTLAPSDSLSQKASPSTIYSPMSASFPYTPASAMSGASDAEAPSLSSAGDARNPFNFQPVTYQPNKPAGVKNDIGRRRGHKYKHSSVSHQIFLEPPPRAPLQLPASLPVPTFKEYRASMSKEQRLRLAWCFCHLCVAGLVGWGAHESLALTVLSRLIFYDALGAFLCVAVDIGSNFEVWKRSTIRHPFGFERSEVIAGLGMSVGLLFMGLDLISHGLTHALEDKGGHTPHHAHTHERVSPGSIDLAALSGIICTVVSATLLKNHARIGKVMRLGALANLPSVLSNPSHFLTLSCSALLLILPLLSIQMYVWLDRTLSFSVALAMVALGWVQGWSLGKMLMMSYSGPGIPAVMYDIETDPAVSAVEEAKFWQVHYGLCQANLRLRVRNLEEIGRLRDRVASMVRNRLGGGYGGGGGQKWEVSTQITLEKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CNR5</accession>
    <name>A0A177CNR5_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1086636</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG09163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039528.1">
        <property type="nucleotide sequence ID" value="XM_018174169.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CNR5"/>
    <dbReference type="STRING" id="1460663.A0A177CNR5"/>
    <dbReference type="GeneID" id="28757655"/>
    <dbReference type="InParanoid" id="A0A177CNR5"/>
    <dbReference type="OrthoDB" id="2958217at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF16">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="10"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG09163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="163" mass="18795" checksum="CE833E32726AD759" modified="2016-09-07" version="1">MDHAPREPFDVLSYCWRSTELNYTTTVSRLESHKQQLPWDQFQKTLQDAIEFTQNLGIPYLWFDALCIVQRSEQDGDAGPVVDKADWAEEAVKMAGLYRHACVTIAALSPRSLNEEFLELITETSPPSSLERHDLFETTQNTPHASRGWTFLELLLSTRILYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CNT2</accession>
    <name>A0A177CNT2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Acetyl-CoA synthetase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CC84DRAFT_1239987</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the NRP synthetase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039007.1">
        <property type="nucleotide sequence ID" value="XM_018183998.1"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CNT2"/>
    <dbReference type="GeneID" id="28767484"/>
    <dbReference type="InParanoid" id="A0A177CNT2"/>
    <dbReference type="OrthoDB" id="416786at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043041">
        <property type="term" value="P:amino acid activation for nonribosomal peptide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19537">
        <property type="entry name" value="C_NRPS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.30">
        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527">
        <property type="entry name" value="NONRIBOSOMAL PEPTIDE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527:SF11">
        <property type="entry name" value="NONRIBOSOMAL PEPTIDE SYNTHETASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="1044"/>
            <end position="1119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAG08642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="1566" mass="173090" checksum="18DD1E069397BBAE" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CNY4</accession>
    <name>A0A177CNY4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Zinc/iron permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CC84DRAFT_1162575</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039057.1">
        <property type="nucleotide sequence ID" value="XM_018178026.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CNY4"/>
    <dbReference type="STRING" id="1460663.A0A177CNY4"/>
    <dbReference type="GeneID" id="28761512"/>
    <dbReference type="InParanoid" id="A0A177CNY4"/>
    <dbReference type="OrthoDB" id="448280at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040:SF60">
        <property type="entry name" value="FAMILY ZINC TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G04010)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040">
        <property type="entry name" value="ZINC/IRON TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="134"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="309"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="400"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="444"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="213"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="219"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="243"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAG08692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="462" mass="49707" checksum="B0A5A78FB9AD3CC2" modified="2016-09-07" version="1">MDTAASNQVARAGAGPQWVDIPTHLLRAELLRRQEQERPECGTKGNRGYYNTPLHVFALVLILTVSTAACSFPIVAKRFPRFPVPHHFLFISRHFGTGVLIATAFVHLLPTAFISLTDPCLPPFWNKGYEAMPGLIAMVSVFVVVGIEMFFASKGAGHSHGMDFEALGADDHEGHSRPGHKRASSYSRFRANGHHHPPDIVLHDIAGSSDNLVAGRSPSFVSSPMTPQPGTRTADSGRNYKDGDEEDSDLDIDPDELGPRGSNDSEDESRLLSQPSAHKHIHLSTSPYAEHMPDMTEAQRKKQLLQCLLLEAGILFHSVFIGMALSVATGTSFIVLLVAITFHQTFEGFALGSRISAVAFPAGSVKPWLMALAYGTTTPIGQAIGLGIHTLYDPASQTGLLMVGFMNAISSGLLLFAGLVELLAEDFLSDESYISLQGKRRLQACGSVVGGAALMALVGAWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CP84</accession>
    <name>A0A177CP84_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PR-1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_434126</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG09333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039698.1">
        <property type="nucleotide sequence ID" value="XM_018186247.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CP84"/>
    <dbReference type="STRING" id="1460663.A0A177CP84"/>
    <dbReference type="GeneID" id="28769733"/>
    <dbReference type="InParanoid" id="A0A177CP84"/>
    <dbReference type="OrthoDB" id="337038at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001283">
        <property type="entry name" value="CRISP-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10334">
        <property type="entry name" value="CYSTEINE-RICH SECRETORY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00837">
        <property type="entry name" value="V5TPXLIKE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00198">
        <property type="entry name" value="SCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008058431" evidence="1">
        <location>
            <begin position="17"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="SCP" evidence="2">
        <location>
            <begin position="40"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG09333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="207" mass="23466" checksum="121514B6EDF68AE5" modified="2016-09-07" version="1">MKLFALVTALAAAALAAPNHALAARDARDSSEIPGIEDQKFISTVLNAHWYWRRIHCAQDLQWNVTLAAMAQKDIRTCTKDVEHMRAGSNLSGQGPSPKKYDEWVEWARVMVHGWHEEETFWDYSARMAKGKHQVYHFTQLVWRDSSQLGCALTDCSDVEGARFPGRIYCYYDPIGNNIAGNFMQENVWPPVCADPSKAELEARFGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CPF3</accession>
    <name>A0A177CPF3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1084328</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG09405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039770.1">
        <property type="nucleotide sequence ID" value="XM_018174049.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CPF3"/>
    <dbReference type="STRING" id="1460663.A0A177CPF3"/>
    <dbReference type="GeneID" id="28757535"/>
    <dbReference type="InParanoid" id="A0A177CPF3"/>
    <dbReference type="OrthoDB" id="2153847at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG09405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="96" mass="9929" checksum="9AAF9A951761DB35" modified="2016-09-07" version="1">MCTLLAVALAAPAAPYSKRQGQNFQTFTGALGGISATPVTDSGNPDRKFQVKGDTFVNIGAALQRSCDQQFNACANKANGGDKTLSVSACSDQKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CPK5</accession>
    <name>A0A177CPK5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1255336</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG09236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039601.1">
        <property type="nucleotide sequence ID" value="XM_018184529.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CPK5"/>
    <dbReference type="GeneID" id="28768015"/>
    <dbReference type="InParanoid" id="A0A177CPK5"/>
    <dbReference type="OrthoDB" id="10539517at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="277"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="53"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="156"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG09236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="298" mass="31522" checksum="292F6944E538EBC4" modified="2016-09-07" version="1">MPHEQLDPAYPAPPFGGSEFPPRTSSRFGTGSYEDMFSSLDAHPVLSRPLMHPGTGQPLTPTTPSESHCPTFRHQRPRTPKSYSHCPPSPRSATYASRPLSPAPPVPPMPPSPHLPLKTSYSTGAISTLAGPGSGPPGPIYAPSRSSSTKSNYTLASSTSAATAASRSSSTTSRRSTMKPRPGPCALPPQPGRHNSLAELHARQTNIDRVVQPISPYAEEPNPLERMGYLVGGIVRRKSSGVELRAENDGERAAGLGGGLGLRKKSSFARLGWGARGGGEYEAERRGSAPGVDVSRNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CQ03</accession>
    <name>A0A177CQ03_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">BAR-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CC84DRAFT_1084798</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG09605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039970.1">
        <property type="nucleotide sequence ID" value="XM_018174069.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CQ03"/>
    <dbReference type="FunCoup" id="A0A177CQ03">
        <property type="interactions" value="279"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CQ03"/>
    <dbReference type="GeneID" id="28757555"/>
    <dbReference type="InParanoid" id="A0A177CQ03"/>
    <dbReference type="OrthoDB" id="2159336at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031097">
        <property type="term" value="C:medial cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990528">
        <property type="term" value="C:Rvs161p-Rvs167p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051666">
        <property type="term" value="P:actin cortical patch localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097320">
        <property type="term" value="P:plasma membrane tubulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07599">
        <property type="entry name" value="BAR_Rvs167p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000048">
        <property type="entry name" value="BAR adaptor protein RVS167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000189">
        <property type="entry name" value="BAR adaptor protein RVS167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004148">
        <property type="entry name" value="BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046982">
        <property type="entry name" value="BIN3/RVS161-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47174">
        <property type="entry name" value="BRIDGING INTEGRATOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47174:SF1">
        <property type="entry name" value="REDUCED VIABILITY UPON STARVATION PROTEIN 167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03114">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00721">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51021">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="BAR" evidence="8">
        <location>
            <begin position="1"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="7">
        <location>
            <begin position="338"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="255"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="10"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="127"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="308"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAG09605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="471" mass="53602" checksum="8EE8370015AF2C7C" modified="2016-09-07" version="1" fragment="single">QGEITKDAVYIDAERRFEELEKETKKLHEESKKYFQAINGMLTHQIEFSKAIAEIYKPISGRMSDPDSFHDEGNAAGIEACGQYEEIVKELQETLKPELEMIETRVIKPADQLLEIIKAVRKMALKRDHKQLDYDRHRAALKKLEEKKDKTLKDEKAMYRAEADVEQATQDYNYFNDLLKDELPKLFKLEREFIQPLFQSFYYMQLNVFYTLHERMQNIDIGYFDLTLDIEAAYEKKRGDVQAQAEAISMVKFKTTGGRKPGQGSKYASKALEAKSERRSSTLSASTDTPPPPYSPTPGVGAIASPPGSATSWGSAAKSKGAAPPPPKPKPSRLSGVPATKTVTALYDYEAQAEGDLSFITGDVIELVTWTENVNEWWIGKVRGKQGQFPGRHINSLKCWNLELMACQATMSSSMHKAGGRDTHRFYFRWHVLVLAGMRGGFCWLTRWSPCRRRLCFRSLILRTILIHVII</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CQR2</accession>
    <name>A0A177CQR2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_1185746</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG09097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039462.1">
        <property type="nucleotide sequence ID" value="XM_018180818.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CQR2"/>
    <dbReference type="GeneID" id="28764304"/>
    <dbReference type="InParanoid" id="A0A177CQR2"/>
    <dbReference type="OrthoDB" id="2985014at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000188">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF9">
        <property type="entry name" value="MAJOR FACILITATOR-TYPE TRANSPORTER HXNP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="31"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="61"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="88"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="153"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="221"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="258"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="288"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="314"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="347"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="380"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="1"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAG09097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="439" mass="48658" checksum="2BC1882D4A3FEA5A" modified="2016-09-07" version="1">MYFFNSVDRSNLGNAKTDGMDKDLGFTGEQYSLLILLFYIPNGLCDLPLNMLTKKYSGKVMLPSLMLFWGAMALLQCAATSFGGMLPLRLLIGASEAGFFAGVVFYLTLFYTRGELGFRISIFFGSALLAAAFSGLISYGVFQIKHSIPGWKWLFIIEGAMTVIIALLAFFWLPASPASAWFLNEAERQLAQRRTLRDLSSTAHSEFSMKDCFRTWKDRKFIAWCIISFTYPVAFATTSNFLPQIVARLGYSVVKTNLWTVAPNAVGFVVLLVVTYSSDYFRERTFHIIFSLCVSLVGLIILATIDVLANKGVAYFACFMLCAGAYIPSCLVHSWHNNNNLSESSRAATTGLLVGLGNLGGIVSAATFRQEYAPKYVPTLAATAACNVVCIVTTAGLGIWMKMENRSRDREQGIKVRPEEVPTEMLGDGEKSEMWRFFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CQS8</accession>
    <name>A0A177CQS8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF1776-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1185759</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG09117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039482.1">
        <property type="nucleotide sequence ID" value="XM_018180819.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CQS8"/>
    <dbReference type="STRING" id="1460663.A0A177CQS8"/>
    <dbReference type="GeneID" id="28764305"/>
    <dbReference type="InParanoid" id="A0A177CQS8"/>
    <dbReference type="OrthoDB" id="5308060at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013952">
        <property type="entry name" value="DUF1776_fun"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43313:SF1">
        <property type="entry name" value="3BETA-HYDROXYSTEROID DEHYDROGENASE DHS-16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43313">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE FAMILY 9C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08643">
        <property type="entry name" value="DUF1776"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG09117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="447" mass="49369" checksum="BA61705509CA5D51" modified="2016-09-07" version="1">MTADDQHFLDVLSEYSQDIRKFTGNIFDASDRHFQSVAGYIKRSVPEGWLPEYARPPPPPPPPRAVSGAYVDRLQDWVSRNRALTAALVAFLATGGVLLWRERNKSRRKRRARRASNGARREVIVLAGPPNSPIIKSLSLDLERRGFIIYIVCSDLEEEQIVQGESRADVRPLHLDVADVLGTQEAMERFKDLLLKPHVAFSGASPHNLLFRGLVLVPDLIYPSGPIETIGPELYSDALNAKVLNTIAVTQAFLPTICEFKARVLMCTPSIVASLRPPFHSVETAVVSALEGFTASLRGELGTLGIDVCQFKLGTFDCSRVGSKHHLQTTAGPNTIVWPATTRKLYATNFVNQSRAAQDRGLLTANSTGSSLRELHDAVFDALSQRRPRRVWRVGRGSITYDVVGNWVPAGLVGWMMGVKRVSLDEATAEPQLEDAAQSWEKVEKAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CRC6</accession>
    <name>A0A177CRC6_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_1171913</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG09319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039684.1">
        <property type="nucleotide sequence ID" value="XM_018179938.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CRC6"/>
    <dbReference type="STRING" id="1460663.A0A177CRC6"/>
    <dbReference type="GeneID" id="28763424"/>
    <dbReference type="InParanoid" id="A0A177CRC6"/>
    <dbReference type="OrthoDB" id="3772622at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37535">
        <property type="entry name" value="FLUG DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37535:SF4">
        <property type="entry name" value="FLUG DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="455"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="605"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="657"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="670"/>
            <end position="680"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAG09319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="956" mass="106539" checksum="3D0BD0B6F93B9EAE" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2023-06-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CSL9</accession>
    <name>A0A177CSL9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1256358</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040899.1">
        <property type="nucleotide sequence ID" value="XM_018184615.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CSL9"/>
    <dbReference type="GeneID" id="28768101"/>
    <dbReference type="InParanoid" id="A0A177CSL9"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008058536" evidence="1">
        <location>
            <begin position="27"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG10534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="403" mass="45310" checksum="185DBE4773AA4DBE" modified="2016-09-07" version="1">MRCCGPFGLLTPLAAYFLYCPLSSSSLKCSCFILSTGGQRRNGDNYDYDFGYDCKYEYIDHFYRSSDRYNHFSLYSCCISNHNNNNEYNHNDFASSDGYVGLYRGCISYYSEHHVYQHHNEHNNKYGDIASSDRYIGIYGCRFFSIHQYNLDHHNDHDIYSDTASRHYYFSIHNRSVYASTTITSTSVPDAVTVTQQGPAEATSTVTIARETTTKEVTTTRSLTFRETLIRLVPTTATQTERTTSTRVINSISTIVTTLPRVTTTRLSTITPASTTLTYRTTLTAAATRFTTQTARETSTSIRYIDRTSTLTIRTTETSFATRISTLRTTSTLFTTRADEFYDADGAHDYDEHQDGEYDTNGADDENIILHEADDDILYDQAGAAAGSNEHGCLGEGLGGRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CUM8</accession>
    <name>A0A177CUM8_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CC84DRAFT_1084471</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041276.1">
        <property type="nucleotide sequence ID" value="XM_018174056.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CUM8"/>
    <dbReference type="GeneID" id="28757542"/>
    <dbReference type="InParanoid" id="A0A177CUM8"/>
    <dbReference type="OrthoDB" id="3529975at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF8">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="136"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="177"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="214"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="252"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="41"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="294"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="363"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="317"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAG10911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="412" mass="45953" checksum="6FAA13D2613F5C06" modified="2016-09-07" version="1">MSAFTPEELVYLEAHKDETRVSEIHWVYSVPIAFGILSTSARLWAKSSGRNGITLDDWLIVVATICLVGECAAGLGYGPPHGMGRHVIVVSPHDQSMVRKGDYVFSHFYDFALVFVKLGILAFYHRVFVVPLFRKVVIATTAFVIAWGIGITVTLILACRPIEAFWDTSVKATCLDLVHFTYFTNITNMVTDVWIFLMPVPVIWHLQLQTKKKLLLCFIFSIGIATCVVSAIRLTVVLGHGYADFTWSYVPLGAYSAFEPLGGILCTNLPIIWHMWRKQRKSEALLPGSSLFRSKHSSAVTPSSHESRRSRIARSLGLSTVDQTGTDSQARTMLDAEEGSSGFGESSTTNRERALFFGKVERIHTQTQEMAETDNRADSGSKRTRSASESGSSRGPRNPNLKKTVWEVRRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CV12</accession>
    <name>A0A177CV12_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Acyltransferase 3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_1133143</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG11394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041759.1">
        <property type="nucleotide sequence ID" value="XM_018175961.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CV12"/>
    <dbReference type="GeneID" id="28759447"/>
    <dbReference type="InParanoid" id="A0A177CV12"/>
    <dbReference type="OrthoDB" id="5405781at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050879">
        <property type="entry name" value="Acyltransferase_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23028">
        <property type="entry name" value="ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23028:SF128">
        <property type="entry name" value="ACYLTRANSFERASE 3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="155"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="189"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="229"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="319"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="361"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="Acyltransferase 3" evidence="3">
        <location>
            <begin position="1"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="402"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="403"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAG11394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="431" mass="48370" checksum="380CDD9CA8F7CA38" modified="2016-09-07" version="1">MVVSGHLCTAFVPWLHSPANDPHTAPHLFQLPFFRLAVGGRSAVALFFLITGYVNSIGPIGRSRAGNTDAAFNGIAKSALARSGRLVLPTMMATALTWFMANINAYHMTKHVDSTWIRQGWHRQEPTLGAAFSSLFKAEVDTWTVGWDDYDGTQWTLHLFLEGSMLVYMTMFATVLVKPKARFIVYAVLYLYFWQLGEGLAVGALKGLNIVFGMFVAELHNHYKDTATSVLPAPIPALMIIAGMFMAGFPQDSPQNAHWSDSMAHFMQAITVEKTDIRRYWDHIGAATVLLGIFFSRNARRVLTSPIFNFLGRVSFPVYLMHNTFIKSVLTWMVYLPSAMNPPRNEKGHQMDLQRGSTTHIFIAVAVFYYVLYRAAALWVQHIDPFCANLVNAATSWAYGESQPRESRPILQTIERRSSPSREKPKLDSPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CWC9</accession>
    <name>A0A177CWC9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_517123</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG11039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041404.1">
        <property type="nucleotide sequence ID" value="XM_018186577.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CWC9"/>
    <dbReference type="GeneID" id="28770063"/>
    <dbReference type="InParanoid" id="A0A177CWC9"/>
    <dbReference type="OrthoDB" id="10530867at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG11039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="192" mass="21339" checksum="1357304151B29F93" modified="2016-09-07" version="1">MCPNRSRQEPAQIVGLARLFLPQRRAAQTQLTLRAAEHSPSPCLLQTASHALWHAPDVSGRAAATRVRRLGVPQTCWRLPPRRQRMLHFGYARARPCCGSTDSPQPRNTAALLRGFLHLTLYRQCSAVLSSWARELLHMAGTSKYIGLQSAIFDKLVLAVTRQSQETAKIVSNPPATVKLGEPHTPDLRKHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CWM5</accession>
    <name>A0A177CWM5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_41109</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG11626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041991.1">
        <property type="nucleotide sequence ID" value="XM_018186103.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CWM5"/>
    <dbReference type="GeneID" id="28769589"/>
    <dbReference type="InParanoid" id="A0A177CWM5"/>
    <dbReference type="OrthoDB" id="5359669at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="275"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG11626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="305" mass="33581" checksum="C3CEB5E5C5E7E487" modified="2016-09-07" version="1">MGLNYYASSPTVVLPPQQAHGYFAPHQRAHLPGTYRPRYPTPPSLNYQASPVSNAKAGRKRSITDVDDPEENRPVGAVVTQQPVKPKPEPVYGPGMTLIYPGEPGYTMAAESQSGTWYEEKIEKEEKAQPVRPIAVSRKSQRMDSATDIVVPSLNDMAMDAQRTDAIVDENGTTLNTLMSSLGVGWKNVITNPSLRDAARAYSRVIENHFDLTDAVILLEKESLSAYLVRAKQHGVQGFWLFSDSLQWGQLVGWSLQRTVQNLMAGPIPQVEGERINARQRTPSEPSTPPSQVPARAADADAMEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CX62</accession>
    <name>A0A177CX62_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HAD-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_53415</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG11791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042156.1">
        <property type="nucleotide sequence ID" value="XM_018186651.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CX62"/>
    <dbReference type="FunCoup" id="A0A177CX62">
        <property type="interactions" value="196"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CX62"/>
    <dbReference type="GeneID" id="28770137"/>
    <dbReference type="InParanoid" id="A0A177CX62"/>
    <dbReference type="OrthoDB" id="40579at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="entry name" value="Putative phosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18901">
        <property type="entry name" value="2-DEOXYGLUCOSE-6-PHOSPHATE PHOSPHATASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18901:SF38">
        <property type="entry name" value="PSEUDOURIDINE-5'-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG11791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="286" mass="31748" checksum="BAA64DBA06B70564" modified="2016-09-07" version="1">MLQHLPPIRACIFDVDGTLINSEDIYTDIYNKILASHNKPPYPWRIKATQQSRGTPGTQRLLDWAELPLTVQEWQQKEKAYTHLFTASKVLPGVEKLLEDLATRTAHQLHLSLASSAGASKFALKTSHIPSIAKAFADKRFHVFGDDPEMSDAKKKPEPDIFLLALKRINEAARQAGGKEVDAMECLVFEDSIAGVEAARRAGMRVVWVPHRGLAEVCEGREEEVLMGRTEADGKVPRYGEKIGAEAKKLEPAEDGRLISEDGLAEMRASLEGFPYETYGIRIAGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CXD5</accession>
    <name>A0A177CXD5_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7053 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1159069</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG11562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041927.1">
        <property type="nucleotide sequence ID" value="XM_018177131.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CXD5"/>
    <dbReference type="STRING" id="1460663.A0A177CXD5"/>
    <dbReference type="GeneID" id="28760617"/>
    <dbReference type="InParanoid" id="A0A177CXD5"/>
    <dbReference type="OrthoDB" id="4276610at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055481">
        <property type="entry name" value="DUF7053"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38117:SF1">
        <property type="entry name" value="DUF3074 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38117">
        <property type="entry name" value="NACHT AND WD40 DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23155">
        <property type="entry name" value="DUF7053"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7053" evidence="2">
        <location>
            <begin position="3"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="220"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="220"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG11562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="240" mass="26895" checksum="E102409897D0467F" modified="2016-09-07" version="1">MRAKHDYHTAAPIPPHVSRDQVLAALHDHTTCLTLQALTTTHSLLPTTDPATLKDTFWYPPDTYPVCSYRVTETIAFLPWFSWAKYRLTFPSVFQNTPTGLKTRADTGGVVLRAEFRVLEGSTMEGIVEGEGEGLGEVGWVLVEDVEVVCAWWMMPLVRGKMEEAHRDICRKVVEKVVKEVAKREGENCDVAVPGEKRIGEVDGDHDVRVDPLAQEEDAYARESVDLTTRDQAPDKITYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CY92</accession>
    <name>A0A177CY92_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1254781</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042909.1">
        <property type="nucleotide sequence ID" value="XM_018184488.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CY92"/>
    <dbReference type="STRING" id="1460663.A0A177CY92"/>
    <dbReference type="GeneID" id="28767974"/>
    <dbReference type="InParanoid" id="A0A177CY92"/>
    <dbReference type="OrthoDB" id="3971593at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG12544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="513" mass="58349" checksum="096EBC246AD06ECC" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CZ91</accession>
    <name>A0A177CZ91_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">N-terminal nucleophile aminohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_1079176</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018043188.1">
        <property type="nucleotide sequence ID" value="XM_018173830.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CZ91"/>
    <dbReference type="STRING" id="1460663.A0A177CZ91"/>
    <dbReference type="GeneID" id="28757316"/>
    <dbReference type="InParanoid" id="A0A177CZ91"/>
    <dbReference type="OrthoDB" id="77601at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004298">
        <property type="term" value="F:threonine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051604">
        <property type="term" value="P:protein maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04514">
        <property type="entry name" value="Taspase1_like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.30:FF:000007">
        <property type="entry name" value="Similar to threonine aspartase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.30">
        <property type="entry name" value="(Glycosyl)asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000246">
        <property type="entry name" value="Peptidase_T2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037464">
        <property type="entry name" value="Taspase1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10188">
        <property type="entry name" value="L-ASPARAGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10188:SF8">
        <property type="entry name" value="THREONINE ASPARTASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01112">
        <property type="entry name" value="Asparaginase_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="215"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="257"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="358"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="397"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="609"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="258"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="440"/>
        </location>
    </feature>
    <feature type="site" description="Cleavage; by autolysis" evidence="2">
        <location>
            <begin position="439"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR600246-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR600246-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAG12823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="635" mass="68062" checksum="D4C82A5CA4C7750E" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CZG9</accession>
    <name>A0A177CZG9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CC84DRAFT_1080641</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018043269.1">
        <property type="nucleotide sequence ID" value="XM_018173901.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CZG9"/>
    <dbReference type="STRING" id="1460663.A0A177CZG9"/>
    <dbReference type="GeneID" id="28757387"/>
    <dbReference type="InParanoid" id="A0A177CZG9"/>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19071">
        <property type="entry name" value="AKR_AKR1-5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000007">
        <property type="entry name" value="NAD(P)H-dependent D-xylose reductase xyl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11732">
        <property type="entry name" value="ALDO/KETO REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00798">
        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="6">
        <location>
            <begin position="19"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="5">
        <location>
            <position position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAG12904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="314" mass="35027" checksum="A2AA5612A8C572ED" modified="2016-09-07" version="1">MAHNGTTASLNTGAKIPLIGFGTWQDKEAQEPAVTIALEAGYRHIDTARIYGTEAAVGNAIKKSGIPREQIFLTTKLWNNKHDPKDVEAALDASLKDLQTDYVDLYLMHWPSAFKPSDEMFPKDSHGNTKTANIDYVDTYKAMEKALKTGKTKAIGISNFSKAELDRLLKETSVVPAAHQMEMHPWLQQKSFADFHKQHNIHITHYSPFGNQNEIYDAGKGMGKLMEDPVLVEIGKKHGKSGAQVALAWGIEKGHSVIPKSKTESRIRQNLEGDFKLDAEDVHKIDGIDKKLRFNDASKSFGYNFFSDLDGKKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CZP0</accession>
    <name>A0A177CZP0_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein transport protein SEC13</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Protein transport protein sec13</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CC84DRAFT_1159827</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules. It also functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. SEC13 is required for efficient mRNA export from the nucleus to the cytoplasm and for correct nuclear pore biogenesis and distribution.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">The COPII coat is composed of at least 5 proteins: the SEC23/24 complex, the SEC13/31 complex, and the protein SAR1. Component of the nuclear pore complex (NPC). NPC constitutes the exclusive means of nucleocytoplasmic transport. NPCs allow the passive diffusion of ions and small molecules and the active, nuclear transport receptor-mediated bidirectional transport of macromolecules such as proteins, RNAs, ribonucleoparticles (RNPs), and ribosomal subunits across the nuclear envelope. Due to its 8-fold rotational symmetry, all subunits are present with 8 copies or multiples thereof.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat SEC13 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042903.1">
        <property type="nucleotide sequence ID" value="XM_018177340.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CZP0"/>
    <dbReference type="FunCoup" id="A0A177CZP0">
        <property type="interactions" value="1054"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CZP0"/>
    <dbReference type="GeneID" id="28760826"/>
    <dbReference type="InParanoid" id="A0A177CZP0"/>
    <dbReference type="OrthoDB" id="364224at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030127">
        <property type="term" value="C:COPII vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061700">
        <property type="term" value="C:GATOR2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031080">
        <property type="term" value="C:nuclear pore outer ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090114">
        <property type="term" value="P:COPII-coated vesicle budding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051664">
        <property type="term" value="P:nuclear pore localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902953">
        <property type="term" value="P:positive regulation of ER to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070863">
        <property type="term" value="P:positive regulation of protein exit from endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032527">
        <property type="term" value="P:protein exit from endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000017">
        <property type="entry name" value="SEC13 homolog (S. cerevisiae)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037363">
        <property type="entry name" value="Sec13/Seh1_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11024">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN SEC13 / SEH1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11024:SF2">
        <property type="entry name" value="PROTEIN SEC13 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="12" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="11" id="KW-0811">Translocation</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <keyword evidence="7 15" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="15">
        <location>
            <begin position="52"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="15">
        <location>
            <begin position="205"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00025261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OAG12538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="298" mass="32653" checksum="71EC1FC0F7AE69BD" modified="2016-09-07" version="1">MANVITNSAGHDDMIHDAVLDYYGRRLATCSSDKTIKIFEVEGESHRLVETLKGHEGAVWCVAWAHPKYGNILASSSYDGKVIIWREQNGTWQKIYDVALHSASVNLVAWAPHEAGCVLACASSDGNVSVLEFKDNNWSHQIFQACGSGVNSVSWAPAYAPGQVITASGNAAGNARRFVTGGSDCQVKLWEFSPESGSYQNSQILPGHTDWVRDVAWSPTVLSKSYIASASQDKTVRIWTSSDLREWKSTVLNVEAVAWRVSWSLSGNVLAVSTGDNRVSLWREKLSGGWECVKTIEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177D024</accession>
    <name>A0A177D024_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CC84DRAFT_158400</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018043126.1">
        <property type="nucleotide sequence ID" value="XM_018185417.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177D024"/>
    <dbReference type="STRING" id="1460663.A0A177D024"/>
    <dbReference type="GeneID" id="28768903"/>
    <dbReference type="InParanoid" id="A0A177D024"/>
    <dbReference type="OrthoDB" id="648861at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF49">
        <property type="entry name" value="LYSINE BIOSYNTHESIS REGULATORY PROTEIN LYS14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="31"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="148"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAG12761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="611" mass="69020" checksum="DAA92EB0A2206F6B" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177D092</accession>
    <name>A0A177D092_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RSC complex subunit Rsc7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_129261</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042947.1">
        <property type="nucleotide sequence ID" value="XM_018185365.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177D092"/>
    <dbReference type="STRING" id="1460663.A0A177D092"/>
    <dbReference type="GeneID" id="28768851"/>
    <dbReference type="InParanoid" id="A0A177D092"/>
    <dbReference type="OrthoDB" id="5598844at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016586">
        <property type="term" value="C:RSC-type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031490">
        <property type="term" value="F:chromatin DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013933">
        <property type="entry name" value="CRC_Rsc7/Swp82"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22597:SF5">
        <property type="entry name" value="LOCALIZATION PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G10600)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22597">
        <property type="entry name" value="POLYCOMB GROUP PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08624">
        <property type="entry name" value="CRC_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="46"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="298"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="359"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="496"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="559"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="115"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="137"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="171"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="307"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="363"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="516"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="602"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="615"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="645"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="678"/>
            <end position="689"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAG12582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="689" mass="75677" checksum="2E18608125FA2F78" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177D1Z6</accession>
    <name>A0A177D1Z6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acyl-CoA N-acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_1136370</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG13069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018043434.1">
        <property type="nucleotide sequence ID" value="XM_018176094.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177D1Z6"/>
    <dbReference type="STRING" id="1460663.A0A177D1Z6"/>
    <dbReference type="GeneID" id="28759580"/>
    <dbReference type="InParanoid" id="A0A177D1Z6"/>
    <dbReference type="OrthoDB" id="41532at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050832">
        <property type="entry name" value="Bact_Acetyltransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43877:SF2">
        <property type="entry name" value="AMINOALKYLPHOSPHONATE N-ACETYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43877">
        <property type="entry name" value="AMINOALKYLPHOSPHONATE N-ACETYLTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="3">
        <location>
            <begin position="21"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAG13069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="182" mass="20545" checksum="EE25AA46BA032022" modified="2016-09-07" version="1">MHIPSSTCSSPPRSITSSQIWAIEAVTPAGVNEVVTFINNARHDMFPTLHTQLTDDVARWVRSGTFLAAKDTASHKLIATIGFVPYDHRFPSLDYQDVHTVEVVRLYVLPRYRRGGLGARLFEELRGRAEEQGVRRLYLHTHPFLPGAVGFWEKRGFGVAGVEEDEVWRTTHMEMVVGRGKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BU44</accession>
    <name>A0A177BU44_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1182135</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441568">
        <property type="protein sequence ID" value="OAF98530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018028896.1">
        <property type="nucleotide sequence ID" value="XM_018180604.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BU44"/>
    <dbReference type="GeneID" id="28764090"/>
    <dbReference type="InParanoid" id="A0A177BU44"/>
    <dbReference type="OrthoDB" id="10419949at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAF98530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="349" mass="38169" checksum="897DDB76EEBF4E76" modified="2016-09-07" version="1">MFSLNSLGMKVQRNETVNFLDYGKVMKIISDGSKRNASVMVINVESTPSCTTSIQHGKRDFDTDTPRDINSLKVSVLPTDLELVPRHEAVDPRVGDYFVIEEVVKALYGNLGAYFAGKVPIPTAPKAFSLEKGLLLELHGFICSQGMFYLINGTLFMRPWVFIDGCSEIVGLAFVETGCWKAGWVDETGLARRKLRRYFKPYIDSDFQFYDLDNDAENCGQVGHKCPEGSSCVGSACTSPTCSGPSSAGSAYGTCLGSGGFDDVKFDLPSAFPPIVGPGSSPKSGWEMSFESLDSYLANDFSLPKDWYLVYDGKRTINTKCVVVGELPFATINAFPENAILTFQTQVVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BVA5</accession>
    <name>A0A177BVA5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Kinesin light chain 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1158040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441563">
        <property type="protein sequence ID" value="OAF99085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029451.1">
        <property type="nucleotide sequence ID" value="XM_018177039.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BVA5"/>
    <dbReference type="STRING" id="1460663.A0A177BVA5"/>
    <dbReference type="GeneID" id="28760525"/>
    <dbReference type="InParanoid" id="A0A177BVA5"/>
    <dbReference type="OrthoDB" id="1658288at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF11">
        <property type="entry name" value="HET-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13374">
        <property type="entry name" value="TPR_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="27"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAF99085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="999" mass="112960" checksum="00259242CBA7B1D3" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BWC6</accession>
    <name>A0A177BWC6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1181183</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441561">
        <property type="protein sequence ID" value="OAF99712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030078.1">
        <property type="nucleotide sequence ID" value="XM_018180534.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BWC6"/>
    <dbReference type="GeneID" id="28764020"/>
    <dbReference type="InParanoid" id="A0A177BWC6"/>
    <dbReference type="OrthoDB" id="3741724at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAF99712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="147" mass="16353" checksum="A88221CE09C57EB8" modified="2016-09-07" version="1">MMNENQLMNVMALNGGHVPAIDSAVKNPSTHVCVLVWSLDGYTRILRKETSTCPLETARALADGLMRDAGDLFAVADVGDQLHGQQGYRGGSGKFELDKFKAMRRFPGPADDTAMLRYENRQDRDDVPRGPAADRKRHHREAPVLDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BWJ3</accession>
    <name>A0A177BWJ3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1169756</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441563">
        <property type="protein sequence ID" value="OAF99048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029414.1">
        <property type="nucleotide sequence ID" value="XM_018179747.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BWJ3"/>
    <dbReference type="GeneID" id="28763233"/>
    <dbReference type="InParanoid" id="A0A177BWJ3"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAF99048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="89" mass="9387" checksum="F07387E9F14D7893" modified="2016-09-07" version="1">MRQPRPMAVSLSLPTASPHPTSLALAPALALRCLACCLGCWLSCCLGSVSEKLTASSIHAPLAFLMPQSRKGSALPMPAWTWSPAWRAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BWX3</accession>
    <name>A0A177BWX3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CC84DRAFT_1191485</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the RBT5 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KV441563">
        <property type="protein sequence ID" value="OAF99007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029373.1">
        <property type="nucleotide sequence ID" value="XM_018181185.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BWX3"/>
    <dbReference type="STRING" id="1460663.A0A177BWX3"/>
    <dbReference type="GeneID" id="28764671"/>
    <dbReference type="InParanoid" id="A0A177BWX3"/>
    <dbReference type="OrthoDB" id="5378633at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008427">
        <property type="entry name" value="Extracellular_membr_CFEM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF160">
        <property type="entry name" value="SAT4 FAMILY MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05730">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00747">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52012">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="12" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="10 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="8 17" id="KW-0732">Signal</keyword>
    <keyword evidence="7 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008057445" description="CFEM domain-containing protein" evidence="17">
        <location>
            <begin position="20"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="174"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="212"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="259"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="292"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="333"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="CFEM" evidence="18">
        <location>
            <begin position="5"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="423"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="423"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="57"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS52012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="OAF99007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="460" mass="50775" checksum="3B7F9E752695D96A" modified="2016-09-07" version="1">MRLWTVLTIFFVFGTSANAQAALQALAKELPPCSLACFMSEIPKTTCANNLTSECLCTNEALNAAVTLCASKTCTVYELLQTKNISSTSCGAPVRSSGRKFIVLGTAGIGLAVLSFILRMAACLKGRSISWDDAAMALVVALAIPPAAFGFMLIDNGLGRDMWTLKDYQITNVLFYYFMGEIFYILALGFSKISILFFYLRVFPAREFRMQIYGVMALCGAYTIAFFFATTFQCIPVSLAWTQWDGLHAGKCNDIHLQGWVAAAINILLDVIVMVLPLKHLAGLNMTLKRKLMVMSMFSVGAIVIFTSAMRLYSLVHFANSHNITWDYVEAGYWSLIEVDVSIICGCMPAHRMLIARAWPKIKLTFHSTKGNSMNSKDFTAASKSNALTSDKAVRVSIKPQTKDDREFVPLVDIDTRNIWTQQTATKESSRSNLSAAESCESDHSDGWPIGRSTTSREHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BXR2</accession>
    <name>A0A177BXR2_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF7730 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1264656</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441563">
        <property type="protein sequence ID" value="OAF99119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029485.1">
        <property type="nucleotide sequence ID" value="XM_018185329.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BXR2"/>
    <dbReference type="GeneID" id="28768815"/>
    <dbReference type="InParanoid" id="A0A177BXR2"/>
    <dbReference type="OrthoDB" id="5413827at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056632">
        <property type="entry name" value="DUF7730"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38790:SF4">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38790">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24864">
        <property type="entry name" value="DUF7730"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7730" evidence="1">
        <location>
            <begin position="79"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAF99119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="261" mass="29941" checksum="1B82CEDA339E6EB5" modified="2016-09-07" version="1">MANAGDPQTAKTYPRVRFLPNGLLDVDRKKGKYFKMVQQNQLSSPLLQLPGEIRSTIYEYVLGDETFTINPAARLLGNSERKKREYLALLQVSRQTYVETVLMPFKLNVFHSDCPQTIRNWMDEANIPIAAQQTITRLQFTLQMHWHAYIKRSVGPFKFEKVVPGWSAHSGAFDQFPALRQIYICTALTQCYCDKPKAQQDALIKYVEKSEEHLKTLIKRSHKATTSNDLDIIFERDLNFALAPAPLDILDVEGDNWSGEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BXT8</accession>
    <name>A0A177BXT8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">FAD/NAD(P)-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CC84DRAFT_1102851</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441560">
        <property type="protein sequence ID" value="OAF99945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030311.1">
        <property type="nucleotide sequence ID" value="XM_018174985.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BXT8"/>
    <dbReference type="STRING" id="1460663.A0A177BXT8"/>
    <dbReference type="GeneID" id="28758471"/>
    <dbReference type="InParanoid" id="A0A177BXT8"/>
    <dbReference type="OrthoDB" id="10016252at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051205">
        <property type="entry name" value="UbiH/COQ6_monooxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43876:SF18">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_3G09540)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43876">
        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS MONOOXYGENASE COQ6, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="4">
        <location>
            <begin position="6"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAF99945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="423" mass="47252" checksum="1C92B7BF89431EE9" modified="2016-09-07" version="1">MPKINHVVVVGCGPSGLLLGTMLARNLSIKVTILDANTEIDKNPRAAHYAPSAMFDFKRAGILEEVREKGLSPRGVCWRLDDTTFLAGMGREPEDTELAMRVLPLDQLGPLIVKHFKSYPNTEILWGHKVVGVKQDENGATAVVETADGERKEITGDYLVGADGASSGVRTALFGKEYPGETLPQQIVATNVYLPFDERFGYWDSNFIVHPTDWYMAAKITKDGIWRVTYGDDASLSREELVKRQPLRYEKILPGHPKPHEYKLVSMSPYKLQQRCAPSFRVGKILLVADAAHLCNPFGGLGLTGGFADVGSLYDCFMGIHQDELDESILDKYSEIRIKIWREMIDPMSRANFHRLWDPACEKEKEEFFKFCERADKDPVWGKSVAEAVHAVRHDFTQYFKSKQKAGMDANVTNGAPAVQAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BY66</accession>
    <name>A0A177BY66_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CC84DRAFT_1231978</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441561">
        <property type="protein sequence ID" value="OAF99628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029994.1">
        <property type="nucleotide sequence ID" value="XM_018183746.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BY66"/>
    <dbReference type="GeneID" id="28767232"/>
    <dbReference type="InParanoid" id="A0A177BY66"/>
    <dbReference type="OrthoDB" id="4139357at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF156">
        <property type="entry name" value="TRANSPORTER, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01036">
        <property type="entry name" value="TCRTETB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="64"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="92"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="122"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="151"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="179"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="209"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="241"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="282"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="313"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="346"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="373"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="413"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="489"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="8"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAF99628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="526" mass="56937" checksum="10D5226D5E68BFE6" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BYB7</accession>
    <name>A0A177BYB7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1264055</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441561">
        <property type="protein sequence ID" value="OAF99678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030044.1">
        <property type="nucleotide sequence ID" value="XM_018185279.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BYB7"/>
    <dbReference type="GeneID" id="28768765"/>
    <dbReference type="InParanoid" id="A0A177BYB7"/>
    <dbReference type="OrthoDB" id="3691658at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAF99678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="215" mass="25033" checksum="7CB291F04DFE6F13" modified="2016-09-07" version="1">MRNSRKSRRISLLLTHPQTEDQQLLLDDLNDDVLAIIVDYLFDMDELNGQRIHLYINTGPYVRTHRSTFNLGVANKRLRSACIRKLFRDIHRCSSTMGQLNRQLKDTEPNSQNLSSIRQSDGKVSSVHNKYYDDDNLPRNWGIIGNHFGRDGFPLVLSFPGDITSYDEKHDPPNYGRETPAEWEADKTRERPPKIEIFDRGSSIQDAEKEWYAKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BYK5</accession>
    <name>A0A177BYK5_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Chromatin assembly factor 1 subunit A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_1200129</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441562">
        <property type="protein sequence ID" value="OAF99506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029872.1">
        <property type="nucleotide sequence ID" value="XM_018181652.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BYK5"/>
    <dbReference type="FunCoup" id="A0A177BYK5">
        <property type="interactions" value="105"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177BYK5"/>
    <dbReference type="GeneID" id="28765138"/>
    <dbReference type="InParanoid" id="A0A177BYK5"/>
    <dbReference type="OrthoDB" id="79480at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033186">
        <property type="term" value="C:CAF-1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048800">
        <property type="entry name" value="Cac1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022043">
        <property type="entry name" value="CAF1A_DD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15272:SF0">
        <property type="entry name" value="CHROMATIN ASSEMBLY FACTOR 1 SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15272">
        <property type="entry name" value="CHROMATIN ASSEMBLY FACTOR 1 SUBUNIT A CAF-1 SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21796">
        <property type="entry name" value="Cac1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12253">
        <property type="entry name" value="CAF1A_dimeriz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromatin assembly factor 1 subunit A dimerization" evidence="6">
        <location>
            <begin position="335"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="Chromatin assembly factor 1 subunit Cac1-like C-terminal" evidence="7">
        <location>
            <begin position="554"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="373"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="28"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="57"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="92"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="184"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="377"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF21796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAF99506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="611" mass="67516" checksum="CB687418AAAB9BC5" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BYM4</accession>
    <name>A0A177BYM4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Phosphoribosylformylglycinamidine synthase</fullName>
            <ecNumber evidence="4">6.3.5.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Formylglycinamide ribonucleotide amidotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Formylglycinamide ribotide amidotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">CC84DRAFT_408599</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide + L-glutamine + ATP + H2O = 2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + L-glutamate + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17129"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:147286"/>
            <dbReference type="ChEBI" id="CHEBI:147287"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 1/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the N-terminal section; belongs to the FGAMS family.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.3" evidence="4"/>
    <dbReference type="EMBL" id="KV441562">
        <property type="protein sequence ID" value="OAF99526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029892.1">
        <property type="nucleotide sequence ID" value="XM_018186080.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A177BYM4">
        <property type="interactions" value="950"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177BYM4"/>
    <dbReference type="GeneID" id="28769566"/>
    <dbReference type="InParanoid" id="A0A177BYM4"/>
    <dbReference type="OrthoDB" id="6666987at2759"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00128"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004642">
        <property type="term" value="F:phosphoribosylformylglycinamidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01740">
        <property type="entry name" value="GATase1_FGAR_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02203">
        <property type="entry name" value="PurL_repeat1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02204">
        <property type="entry name" value="PurL_repeat2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.10:FF:000002">
        <property type="entry name" value="Phosphoribosylformylglycinamidine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.10:FF:000005">
        <property type="entry name" value="Phosphoribosylformylglycinamidine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.880:FF:000008">
        <property type="entry name" value="Phosphoribosylformylglycinamidine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.650.10:FF:000002">
        <property type="entry name" value="Phosphoribosylformylglycinamidine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.650.10:FF:000005">
        <property type="entry name" value="Phosphoribosylformylglycinamidine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.750">
        <property type="entry name" value="Phosphoribosylformylglycinamidine synthase, linker domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.650.10">
        <property type="entry name" value="PurM-like C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.10">
        <property type="entry name" value="PurM-like, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00419">
        <property type="entry name" value="PurL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040707">
        <property type="entry name" value="FGAR-AT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055181">
        <property type="entry name" value="FGAR-AT_PurM_N-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010073">
        <property type="entry name" value="PurL_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041609">
        <property type="entry name" value="PurL_linker"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010918">
        <property type="entry name" value="PurM-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036676">
        <property type="entry name" value="PurM-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036921">
        <property type="entry name" value="PurM-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036604">
        <property type="entry name" value="PurS-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003672">
        <property type="entry name" value="PRK05297.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10099">
        <property type="entry name" value="PHOSPHORIBOSYLFORMYLGLYCINAMIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10099:SF1">
        <property type="entry name" value="PHOSPHORIBOSYLFORMYLGLYCINAMIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02769">
        <property type="entry name" value="AIRS_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18072">
        <property type="entry name" value="FGAR-AT_linker"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18076">
        <property type="entry name" value="FGAR-AT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22689">
        <property type="entry name" value="FGAR-AT_PurM_N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13507">
        <property type="entry name" value="GATase_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01211">
        <property type="entry name" value="GATase_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109736">
        <property type="entry name" value="FGAM synthase PurL, linker domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56042">
        <property type="entry name" value="PurM C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55326">
        <property type="entry name" value="PurM N-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82697">
        <property type="entry name" value="PurS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphoribosylformylglycinamidine synthase N-terminal" evidence="20">
        <location>
            <begin position="38"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphoribosylformylglycinamidine synthase linker" evidence="19">
        <location>
            <begin position="195"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="PurM-like C-terminal" evidence="18">
        <location>
            <begin position="461"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="domain" description="FGAR-AT PurM N-terminal-like" evidence="21">
        <location>
            <begin position="697"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="domain" description="PurM-like C-terminal" evidence="18">
        <location>
            <begin position="860"/>
            <end position="993"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00029823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00032632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00052585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00057317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00071729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF02769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF18072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF18076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF22689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="OAF99526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="1341" mass="145947" checksum="E7FDB691861FFB18" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BYQ1</accession>
    <name>A0A177BYQ1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Nucleoporin Nup159/Nup146 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CC84DRAFT_1156652</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441561">
        <property type="protein sequence ID" value="OAF99657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030023.1">
        <property type="nucleotide sequence ID" value="XM_018176981.1"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177BYQ1"/>
    <dbReference type="GeneID" id="28760467"/>
    <dbReference type="InParanoid" id="A0A177BYQ1"/>
    <dbReference type="OrthoDB" id="248320at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039462">
        <property type="entry name" value="Nup159/Nup146_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16755">
        <property type="entry name" value="Beta-prop_NUP159_NUP214"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117289">
        <property type="entry name" value="Nucleoporin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nucleoporin Nup159/Nup146 N-terminal" evidence="5">
        <location>
            <begin position="50"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="453"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1231"/>
            <end position="1270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="458"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="473"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="582"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="629"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="661"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="715"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="748"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="774"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="848"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="908"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="933"/>
            <end position="942"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAF99657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="1354" mass="144239" checksum="01BFDD63B29ECC76" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2023-06-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BZ15</accession>
    <name>A0A177BZ15_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1180724</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441560">
        <property type="protein sequence ID" value="OAF99871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030237.1">
        <property type="nucleotide sequence ID" value="XM_018180502.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BZ15"/>
    <dbReference type="GeneID" id="28763988"/>
    <dbReference type="InParanoid" id="A0A177BZ15"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAF99871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="169" mass="17972" checksum="DA72058743ECF0A2" modified="2016-09-07" version="1">MAADDVVAIDGRWYQYLGSNGRILACRRVAAGRHGAASRMHSMTAVGHSHMQHVPKGCSNQERRGTADAGRQWGWCQAPGVHRDTLAASTAATASELAMSSDKAPRRPAWRCLSHGRRECQRRPPPRHAASAPTCRQAIHGLWLLTAASPTPAAVYPLPAPAAALGSGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C064</accession>
    <name>A0A177C064_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Ornithine decarboxylase</fullName>
            <ecNumber evidence="10">4.1.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CC84DRAFT_316534</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the first and rate-limiting step of polyamine biosynthesis that converts ornithine into putrescine, which is the precursor for the polyamines, spermidine and spermine. Polyamines are essential for cell proliferation and are implicated in cellular processes, ranging from DNA replication to apoptosis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-ornithine + H(+) = putrescine + CO2</text>
            <dbReference type="Rhea" id="RHEA:22964"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:326268"/>
            <dbReference type="EC" id="4.1.1.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 15">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="9">Amine and polyamine biosynthesis; putrescine biosynthesis via L-ornithine pathway; putrescine from L-ornithine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Homodimer. Only the dimer is catalytically active, as the active sites are constructed of residues from both monomers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Orn/Lys/Arg decarboxylase class-II family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.17" evidence="10"/>
    <dbReference type="EMBL" id="KV441559">
        <property type="protein sequence ID" value="OAG00631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030996.1">
        <property type="nucleotide sequence ID" value="XM_018185839.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C064"/>
    <dbReference type="FunCoup" id="A0A177C064">
        <property type="interactions" value="1466"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177C064"/>
    <dbReference type="GeneID" id="28769325"/>
    <dbReference type="InParanoid" id="A0A177C064"/>
    <dbReference type="OrthoDB" id="5034579at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004586">
        <property type="term" value="F:ornithine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033387">
        <property type="term" value="P:putrescine biosynthetic process from arginine, via ornithine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00622">
        <property type="entry name" value="PLPDE_III_ODC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.37.10:FF:000010">
        <property type="entry name" value="Ornithine decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.10:FF:000005">
        <property type="entry name" value="Ornithine decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="entry name" value="Alanine racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.37.10">
        <property type="entry name" value="Lyase, Ornithine Decarboxylase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009006">
        <property type="entry name" value="Ala_racemase/Decarboxylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022657">
        <property type="entry name" value="De-COase2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022644">
        <property type="entry name" value="De-COase2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022653">
        <property type="entry name" value="De-COase2_pyr-phos_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000183">
        <property type="entry name" value="Orn/DAP/Arg_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002433">
        <property type="entry name" value="Orn_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11482">
        <property type="entry name" value="ARGININE/DIAMINOPIMELATE/ORNITHINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11482:SF6">
        <property type="entry name" value="ORNITHINE DECARBOXYLASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02784">
        <property type="entry name" value="Orn_Arg_deC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01179">
        <property type="entry name" value="ODADCRBXLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01182">
        <property type="entry name" value="ORNDCRBXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50621">
        <property type="entry name" value="Alanine racemase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="PLP-binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00878">
        <property type="entry name" value="ODR_DC_2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00879">
        <property type="entry name" value="ODR_DC_2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-0620">Polyamine biosynthesis</keyword>
    <keyword evidence="6 15" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Orn/DAP/Arg decarboxylase 2 N-terminal" evidence="16">
        <location>
            <begin position="70"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="15">
        <location>
            <position position="382"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="15">
        <location>
            <position position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00034138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00037173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00039485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00046672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR600183-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="OAG00631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="444" mass="48820" checksum="D1B4C3E37DDB5AC5" modified="2016-09-07" version="1">MAPSAITPTEEYKFTYQDYKSVEPNLGTTDNHGAALSKQLKGEALKSRVEAVDPDTCDVGDEDAFFVADLGEVYRQHLRWKKNLGRVKPHYAVKCNPDPQVLRLLSELGTGFDCASKNEIETVLKMGVDPARIIYAQPCKTKGYLRYATNAGVKQMTFDNADELYKTKQIAPDAELYLRILTDDSASLCRLSQKFGACVDTTGELLELAKKLELNVVGVAFHVGSGASDPKAFIKAVQDARFVFDQAAALGFTMHTLDVGGGFTGDESFEPMAAVLSASLDEYFPPSVRIIGEPGRYFVSTAFTLACHVIARRTVTDATLGTTSYMLYMNDGVYGNFSSIIFDHQHPVPRVLKNGKDIMYDVRRSGYDTPSMIEYSIWGPTCDGIDVISSSCSFPEVLNVNDWLYFEDMGAYTKCSATRFNGFTNDHDTVYVCSEPGASALLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C0B3</accession>
    <name>A0A177C0B3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1209747</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441560">
        <property type="protein sequence ID" value="OAG00050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030415.1">
        <property type="nucleotide sequence ID" value="XM_018182236.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C0B3"/>
    <dbReference type="STRING" id="1460663.A0A177C0B3"/>
    <dbReference type="GeneID" id="28765722"/>
    <dbReference type="InParanoid" id="A0A177C0B3"/>
    <dbReference type="OrthoDB" id="3765343at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008057543" evidence="1">
        <location>
            <begin position="20"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG00050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="194" mass="23660" checksum="0DF3B70B67E30A5A" modified="2016-09-07" version="1">MRVSTVSAIIGLTAGFASAAPVKPKEVQNRDADPQWYDITYVDKRTEEEKRKADPQWYDITYVDKRAEEEKKRKAEPQWYDITYVDKRTEEEKRKADPQWYDITYVDKRAEEEKKRQWYDITYVDKRAEGEKKRKADPQWYDITYVDKRTEEEKRKADPQWYDITYVDKRAEEEKKRKADPQWYDITYVDKRAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C0M8</accession>
    <name>A0A177C0M8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_279879</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441558">
        <property type="protein sequence ID" value="OAG01193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031558.1">
        <property type="nucleotide sequence ID" value="XM_018185740.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C0M8"/>
    <dbReference type="GeneID" id="28769226"/>
    <dbReference type="InParanoid" id="A0A177C0M8"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG01193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="164" mass="18103" checksum="6DC2D37AB0F669E8" modified="2016-09-07" version="1">MDSHALGATVGNNKTRMMSYGRRQSFCCVCAWLWSLSKLNARFVALTTYKCTVRLRGPPIQPIRVPSFLDLPDFPSTTPVLRRTISGERAGSVRLHRYAMDLQACRGEQAPHISQAILLHHKTSWALPPVGGASLGIRGWAAGEDGGRDEVREKVRESTNKATT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C0P0</accession>
    <name>A0A177C0P0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative oxidoreductase ucpA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_281785</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441559">
        <property type="protein sequence ID" value="OAG00277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030642.1">
        <property type="nucleotide sequence ID" value="XM_018185763.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C0P0"/>
    <dbReference type="STRING" id="1460663.A0A177C0P0"/>
    <dbReference type="GeneID" id="28769249"/>
    <dbReference type="InParanoid" id="A0A177C0P0"/>
    <dbReference type="OrthoDB" id="1933717at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44196">
        <property type="entry name" value="DEHYDROGENASE/REDUCTASE SDR FAMILY MEMBER 7B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44196:SF1">
        <property type="entry name" value="DEHYDROGENASE_REDUCTASE SDR FAMILY MEMBER 7B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAG00277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="303" mass="33275" checksum="676E63F825D20001" modified="2016-09-07" version="1">MSEPPAYTGYFFPGRENLRHDIYSTICAAQSSLLKQPRKVVLITGAGRGIGRATALQYAHADVSCIILCARTASQLDEVQSEIHNINESIRVHKFSMDVTDDSAVAHCAEEVQSTEGRLDVLVNNAGSSAPWVPISESDPERYWGSLTVNIKGPYLFLHAFLPLLKITARGYNTTTTVINMTSVGAHTVYPGLSEYCIGKVALNTLTQFVDAEYREHGIQAFAVHPGGIDTEMARSDETFIKGLEGLLIDTVELPGGFCVWLSAAERKWLSGRYLAAPWDVERLEQMQDEIVAGDKLKAKLVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C0P6</accession>
    <name>A0A177C0P6_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_300963</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441559">
        <property type="protein sequence ID" value="OAG00378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030743.1">
        <property type="nucleotide sequence ID" value="XM_018185791.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C0P6"/>
    <dbReference type="GeneID" id="28769277"/>
    <dbReference type="InParanoid" id="A0A177C0P6"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG00378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="206" mass="23409" checksum="0707591A19A0D426" modified="2016-09-07" version="1">MELGRCIYHRLGGERGNPAWNYRLQRVRLFFYFTSCPVLSSFLLFSHLLTSLPFDRPLGIHDGTSPHSGQADHQTEWRSRAFKELWGRATEENTYSIVSGCYTVHKSNKMGRKAMAISAKHSPRVPRTILMFLDVASAPVVPLLRHPFACCAGLGRGFPKLPAVIAVAPSVKTPANHTRFLPAQTIVYHDAFFFRPFRSHYQPRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C0R9</accession>
    <name>A0A177C0R9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CC84DRAFT_363479</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441560">
        <property type="protein sequence ID" value="OAG00210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030575.1">
        <property type="nucleotide sequence ID" value="XM_018185923.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C0R9"/>
    <dbReference type="STRING" id="1460663.A0A177C0R9"/>
    <dbReference type="GeneID" id="28769409"/>
    <dbReference type="InParanoid" id="A0A177C0R9"/>
    <dbReference type="OrthoDB" id="5061070at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031623">
        <property type="term" value="P:receptor internalization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08771">
        <property type="entry name" value="DLP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1240">
        <property type="entry name" value="Dynamin, middle domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022812">
        <property type="entry name" value="Dynamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001401">
        <property type="entry name" value="Dynamin_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000375">
        <property type="entry name" value="Dynamin_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030381">
        <property type="entry name" value="G_DYNAMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003130">
        <property type="entry name" value="GED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020850">
        <property type="entry name" value="GED_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566">
        <property type="entry name" value="DYNAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566:SF131">
        <property type="entry name" value="GTPASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G07630)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01031">
        <property type="entry name" value="Dynamin_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02212">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00195">
        <property type="entry name" value="DYNAMIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00053">
        <property type="entry name" value="DYNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51718">
        <property type="entry name" value="G_DYNAMIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51388">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynamin-type G" evidence="5">
        <location>
            <begin position="116"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="domain" description="GED" evidence="4">
        <location>
            <begin position="778"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="550"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="897"/>
            <end position="918"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAG00210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="918" mass="102719" checksum="62706276DD7F131B" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C147</accession>
    <name>A0A177C147_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Geranylgeranyl pyrophosphate synthetase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_280472</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441558">
        <property type="protein sequence ID" value="OAG01215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031580.1">
        <property type="nucleotide sequence ID" value="XM_018185747.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C147"/>
    <dbReference type="STRING" id="1460663.A0A177C147"/>
    <dbReference type="GeneID" id="28769233"/>
    <dbReference type="InParanoid" id="A0A177C147"/>
    <dbReference type="OrthoDB" id="5393654at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35179">
        <property type="entry name" value="PROTEIN CBG02620"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35179:SF2">
        <property type="entry name" value="START DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="426"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="426"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG01215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="472" mass="53083" checksum="60EF01AFC8AF2633" modified="2016-09-07" version="1">MSFRPNRGYERAGFATRPGRGRGWGRGRGGAQHLVNRMVVKPDIVKHPLGQLLQTFRLADLQPSEDNTGKVNKITNCEYVASYSWTNSESPTILVPGRPPLWMPLQQPQRLPEDSGVYFRDPNSAKFPRHPTEPAVRALFKTDPAFPTGEVDVFACGSTMGSLLRFVLSIDKPFRFNVEVIGSTVFLIRKENDPREIIEGVRGFGHTFPEYYTTWEQDVKGSETHQRLCRYDLGRFNCVIRFECDGYLQTGSEKTSMVETKSSDLEDLSGNFKNVTVGQGTVNGLAKLLLKQGGAVVAQHTIFDMKTRSGRYRKEINMDEMYPQLWIKQIPNFIIAYHDGAGLFPTSDIQVQNVNYNVQAWERQNQAGISRLIVLLDKIVELARNEGTGLLEVYCPSVDCLEVRKQYGEGFHALPLELSAKWKAMDQDSTDPDHEHDTEPGHGGLQLGYDSDDEPDYTACGDDCGYCGKCTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C1I6</accession>
    <name>A0A177C1I6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Amino acid transporter-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CC84DRAFT_1231104</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441559">
        <property type="protein sequence ID" value="OAG00739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031104.1">
        <property type="nucleotide sequence ID" value="XM_018183715.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C1I6"/>
    <dbReference type="STRING" id="1460663.A0A177C1I6"/>
    <dbReference type="GeneID" id="28767201"/>
    <dbReference type="InParanoid" id="A0A177C1I6"/>
    <dbReference type="OrthoDB" id="3257095at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF1">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="46"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="85"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="127"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="175"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="203"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="243"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="280"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="338"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="382"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="408"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="469"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="500"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAG00739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="547" mass="60777" checksum="227D90B1C1E7FD4E" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C1I7</accession>
    <name>A0A177C1I7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1180584</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441559">
        <property type="protein sequence ID" value="OAG00587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030952.1">
        <property type="nucleotide sequence ID" value="XM_018180485.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C1I7"/>
    <dbReference type="GeneID" id="28763971"/>
    <dbReference type="InParanoid" id="A0A177C1I7"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG00587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="276" mass="30269" checksum="467EA501022755CD" modified="2016-09-07" version="1">MNPPTIETREKREGAHNTVTYSMSSLGITQQNAGASPAQTLHIRTNDGDPGRIVSVLDTNGPWNTGSSITPIDRRLPQSTGREPNNPMCEWAPCPTRGIRKSRQGKREEVPSGRHLLLTLRGHPLTIGLYYVDNYTFAIAKLRPSSLMPLEVQKCELGWILFAARISAFSVLPAPPSQLERLGRLVLMREASTGIRPLGSLEVISAFSVRPAHTSDSARAPDSPHTQIFQTLRNGRTELKSLAQVAAIFVEERVTGPIRTEIVLGCGAQHRPSGHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C2D0</accession>
    <name>A0A177C2D0_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_1055286</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441557">
        <property type="protein sequence ID" value="OAG01803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032168.1">
        <property type="nucleotide sequence ID" value="XM_018173532.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C2D0"/>
    <dbReference type="STRING" id="1460663.A0A177C2D0"/>
    <dbReference type="GeneID" id="28757018"/>
    <dbReference type="InParanoid" id="A0A177C2D0"/>
    <dbReference type="OrthoDB" id="5278984at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF55">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="52"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="94"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="128"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="171"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="212"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="249"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="36"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAG01803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="287" mass="31865" checksum="DCEEB983B984D4C0" modified="2016-09-07" version="1" fragment="single">MAVNVGFPADGAENQGWKLYLTSLIMVLCAGLFVIARVLTRVRIFGLKADDYAIIASLTFSIFLSIAIQLAVVHGYGKHVRDLSKPELRTCLKFFWLAQTPYKIVVCLNKTSVILLYMRIFIGHRFRLLCSCALAIVIGSGIATVFATIFQCVPLERSWNKTVEGKCIDSSAFWIANAVINISTDVIVLALPVHEVIKLQLRLRERIMLHSVFLLGGFVTVTSILRVTAVANSVHNHKDQTWEFIRRGVWTLIEANLGIICACLIVLRQPLARLCSKVFGATKTGTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C394</accession>
    <name>A0A177C394_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_1252815</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441556">
        <property type="protein sequence ID" value="OAG02214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032579.1">
        <property type="nucleotide sequence ID" value="XM_018184364.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C394"/>
    <dbReference type="STRING" id="1460663.A0A177C394"/>
    <dbReference type="GeneID" id="28767850"/>
    <dbReference type="InParanoid" id="A0A177C394"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039903">
        <property type="entry name" value="Zswim2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21540:SF0">
        <property type="entry name" value="PHD FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21540">
        <property type="entry name" value="RING FINGER AND SWIM DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="3">
        <location>
            <begin position="256"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="104"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="197"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="312"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="116"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="197"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="223"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="313"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAG02214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="389" mass="42433" checksum="00C1C482DD4F3311" modified="2016-09-07" version="1">MTPRTRTSPLWDPSTVLKIDSMGRCAGWAHTRGRNCANTIAFHNQQNAEYLLKTISTKEPDPIALEDDLYDLAGFVLCRRWHQDQADAMVEKWSARMERFATARRVLNGGRRSRGSRTSSSGTSEAATPSTSPSSSGSEISAMQSLMSQHLDRIAQLEAMIATLSARVTPSQEATATSVTPGEVTPPVQVTPPVQATPPVQVTPPVQGAPATSAPIPVHRRIPSQPRRSSPSAAQPVTQRPCAIPHVRRRAVDDDCPICHDAFLADEALVWCKRECGRTVHKTCFAGWEKVSRDEGKPVKCGMCRAAWERSSRSPVESTAPQSPTSHLHAKQPVPVSLSAAPQLDYSQIFDRAGFSCPHVFPDARMAALTRFPDWHTGWSDSSLATASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C3N9</accession>
    <name>A0A177C3N9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1220808</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441557">
        <property type="protein sequence ID" value="OAG01280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031645.1">
        <property type="nucleotide sequence ID" value="XM_018183202.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C3N9"/>
    <dbReference type="GeneID" id="28766688"/>
    <dbReference type="InParanoid" id="A0A177C3N9"/>
    <dbReference type="OrthoDB" id="3796455at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="83"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG01280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="183" mass="19242" checksum="BD9FF5A389D41C29" modified="2016-09-07" version="1">MPPKKDDSAATVGDAITGFTSKETKMIAAAFVASTGPDKYDYELLATLTGNTAGSLKKMWPPVKRKVIEAHASFGTFLGGAAGEAAAAKPAPKPKANNGKKRKATSAEPEQEDEAGVEDAGKKKPGPKGRKKKADSVDAETEEKKPAVKRGRKKVKSEEDVADDEIMEEIAEETAAAAAQEEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C3S8</accession>
    <name>A0A177C3S8_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1262603</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441557">
        <property type="protein sequence ID" value="OAG01549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031914.1">
        <property type="nucleotide sequence ID" value="XM_018185163.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C3S8"/>
    <dbReference type="GeneID" id="28768649"/>
    <dbReference type="InParanoid" id="A0A177C3S8"/>
    <dbReference type="OrthoDB" id="3140657at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42057">
        <property type="entry name" value="F-BOX DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_4G00200)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42057:SF2">
        <property type="entry name" value="F-BOX DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_4G00200)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG01549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="520" mass="60478" checksum="D6BB0975F8B7F12C" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C4H5</accession>
    <name>A0A177C4H5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1167459</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441556">
        <property type="protein sequence ID" value="OAG02405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032770.1">
        <property type="nucleotide sequence ID" value="XM_018179182.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C4H5"/>
    <dbReference type="GeneID" id="28762668"/>
    <dbReference type="InParanoid" id="A0A177C4H5"/>
    <dbReference type="OrthoDB" id="3766445at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG02405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="243" mass="27368" checksum="2C277F425214DB43" modified="2016-09-07" version="1">MHGAVIKRAQIEQFNVDMAAFAKSPNEEIEMHSVTDRLVQVQHQAEKHNAVIGAIPALEALITSHAHFPFTNPVMLTRDALLRAVLLLTDHASLPFRQACQVGDDYEIRTHSEKERLRFIYSALACSPIGVPTQDDVLDVVSRVEYPWRTWAKGIIRRQLLDDFRPLAERLAPARDVEVPESLPVKKLEPLRELATAFPLRWGDPAAVVGFGGEGAVTREQFVEWATKVRNYPRAMVLYLAKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C556</accession>
    <name>A0A177C556_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycoside hydrolase family 93 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1189558</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441556">
        <property type="protein sequence ID" value="OAG02291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032656.1">
        <property type="nucleotide sequence ID" value="XM_018181064.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C556"/>
    <dbReference type="STRING" id="1460663.A0A177C556"/>
    <dbReference type="GeneID" id="28764550"/>
    <dbReference type="InParanoid" id="A0A177C556"/>
    <dbReference type="OrthoDB" id="2130735at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15482">
        <property type="entry name" value="Sialidase_non-viral"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38792">
        <property type="entry name" value="BNR/ASP-BOX REPEAT DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_7G06430)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38792:SF3">
        <property type="entry name" value="BNR_ASP-BOX REPEAT DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_7G06430)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110296">
        <property type="entry name" value="Oligoxyloglucan reducing end-specific cellobiohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008057749" evidence="1">
        <location>
            <begin position="19"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG02291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="377" mass="41188" checksum="42181B26A8E9B4EA" modified="2016-09-07" version="1">MKIASILSVLALASSAVAKPLAAKAPATFAQRVVFEPPRNANWTDPGVLYARSAQLPNGDLLATWENYSPEPPKVYFPIYKSTDNGYTWKELSRVQDTQNGWGLRYQPFLYVLPEALGGFPAGTVLVSGSSIPTDLSKTQIELYASRDSGETWKFVSHIAAGGVAVPNNGETPVWEPFLYKHKDTLICYYSDQRDAKYGQKMVHQTTKDLKTWGPVVDDVTYPTYTDRPGMPTIAKLPNGQFIMTYEYGGNHGTTSYSFPVHYKIVSDPEKFGAATGVQLKATDGTAPSGSPYVVWSSVGGKNGTIIASGHSNSEIFINTQLGQGAWKKVATPELTHYTRHLRVLKDQTKLVIMGGGQLPPSSTNKVQLSVMDISKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C5P5</accession>
    <name>A0A177C5P5_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CC84DRAFT_1261604</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG02943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033308.1">
        <property type="nucleotide sequence ID" value="XM_018185080.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C5P5"/>
    <dbReference type="STRING" id="1460663.A0A177C5P5"/>
    <dbReference type="GeneID" id="28768566"/>
    <dbReference type="InParanoid" id="A0A177C5P5"/>
    <dbReference type="OrthoDB" id="5818554at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052780">
        <property type="entry name" value="AAA_Catabolism_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31644">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR ARO80-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31644:SF1">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="32"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="92"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="154"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="666"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="122"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="155"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="666"/>
            <end position="685"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAG02943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="761" mass="82999" checksum="003E5A3810BAF5CC" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C643</accession>
    <name>A0A177C643_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">t-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1046046</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SNAP-25 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG02995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033360.1">
        <property type="nucleotide sequence ID" value="XM_018173413.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C643"/>
    <dbReference type="FunCoup" id="A0A177C643">
        <property type="interactions" value="119"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177C643"/>
    <dbReference type="GeneID" id="28756899"/>
    <dbReference type="InParanoid" id="A0A177C643"/>
    <dbReference type="OrthoDB" id="18679at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19305">
        <property type="entry name" value="SYNAPTOSOMAL ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19305:SF9">
        <property type="entry name" value="SYNAPTOSOMAL-ASSOCIATED PROTEIN 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG02995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="223" mass="25445" checksum="AFB3AAEEAB94745B" modified="2016-09-07" version="1" fragment="single">DSEPDLTAVKQEIRTFKLADVHRTRTALSLAHSAREIGLSTLSRLRTQNERLANTDIHIHEAGVQNRIASQQIRTLKRARRFLPAAGNPFTAGRRGRQGDEAALAVHRREREQRDALRWARWEEAFRRRVTVTVALPAEDGKLARLVERAKYQFEPDSEDDLFEGEIEGNLDRLVEVAPQLREIAVEMGRAVEEGTRRLEGMMERMDAVDDGLVRNRHALGRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C6V6</accession>
    <name>A0A177C6V6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1250355</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG02602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032967.1">
        <property type="nucleotide sequence ID" value="XM_018184304.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C6V6"/>
    <dbReference type="GeneID" id="28767790"/>
    <dbReference type="InParanoid" id="A0A177C6V6"/>
    <dbReference type="OrthoDB" id="10655916at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG02602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="244" mass="26440" checksum="8DC977B2250498A0" modified="2016-09-07" version="1">MALYLFTSEGRFKRTLGLKDLLPRRATQRPSERVGLLSTAQGSRIGGRCANLTKTLGSVDERGTSSDKARKRTECWTLLGPHSQPRSIATQEQGQLHLGTAMSDNAAASNSPRSVLLEGAWKNGSASAGGRSPRREEDGSDFGATPTPVVRFQFGRSSRLTARTRASWRPGTQQTLFLYQHRHTHSSLITLALRPSPNNARGASAEQKFAKARAVHMSSSPAVRPHKTQENGSTAPYCVPCCAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C764</accession>
    <name>A0A177C764_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ribosomal protein S2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1166422</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG02587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032952.1">
        <property type="nucleotide sequence ID" value="XM_018178960.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C764"/>
    <dbReference type="FunCoup" id="A0A177C764">
        <property type="interactions" value="722"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177C764"/>
    <dbReference type="GeneID" id="28762446"/>
    <dbReference type="InParanoid" id="A0A177C764"/>
    <dbReference type="OrthoDB" id="2320368at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01425">
        <property type="entry name" value="RPS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10490:FF:000061">
        <property type="entry name" value="40S ribosomal protein S2, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10490">
        <property type="entry name" value="Glucose-6-phosphate isomerase like protein, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00291_B">
        <property type="entry name" value="Ribosomal_uS2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001865">
        <property type="entry name" value="Ribosomal_uS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005706">
        <property type="entry name" value="Ribosomal_uS2_bac/mit/plastid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023591">
        <property type="entry name" value="Ribosomal_uS2_flav_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01011">
        <property type="entry name" value="rpsB_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12534">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S2 PROKARYOTIC AND ORGANELLAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12534:SF0">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00318">
        <property type="entry name" value="Ribosomal_S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00395">
        <property type="entry name" value="RIBOSOMALS2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52313">
        <property type="entry name" value="Ribosomal protein S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="63"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG02587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="399" mass="43752" checksum="5C9C32668E177E09" modified="2016-09-07" version="1">MMIIRSVARAGHRAFLQSPSQPWRRFLATQTDTIERTADNSFKQFHSLEAQYDASAPPQEVVPSFDPPAASDPASAQVTGSVAEQYLRFKQSQAQIGKIGSEITPHYQPHTLLSNPPSPADVTLELLLASEAHQGHATSLWNPANARYIHGIRQGVHIISLEATAAHLRRAAKVVQEVSRRGGLVLFVGTRDGQDRAVARASELAKGYHLFERWIPGSITNGQQILSKCRTKVVNAKDEEIPGFEEQLADRPVLRPDLVVCMNPLENYVLLHECALNNIPTIGVIDTNADPTWVTYPIPANDDSLRCIQVIAGVLGRAGEAGQKQRLELAENGRVTYRPAENLVLPEAMQEKTVAAAEPGAELDLNESLEDADELADKLDMAKNREISDHAARGIKKID</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C778</accession>
    <name>A0A177C778_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Thioredoxin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1188180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG03493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033858.1">
        <property type="nucleotide sequence ID" value="XM_018180976.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C778"/>
    <dbReference type="STRING" id="1460663.A0A177C778"/>
    <dbReference type="GeneID" id="28764462"/>
    <dbReference type="InParanoid" id="A0A177C778"/>
    <dbReference type="OrthoDB" id="1930760at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03024">
        <property type="entry name" value="DsbA_FrnE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001853">
        <property type="entry name" value="DSBA-like_thioredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13887">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE KAPPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13887:SF41">
        <property type="entry name" value="THIOREDOXIN SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01323">
        <property type="entry name" value="DSBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DSBA-like thioredoxin" evidence="1">
        <location>
            <begin position="6"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG03493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="229" mass="25520" checksum="AC59B7D25C2381E2" modified="2016-09-07" version="1">MTNFNIDIVSDTVCPWCYVGKKRLEKGIAAYKAAHPNSDDTFSTNWFPFYLNPDSPKTGIDKTAYYRQKFGDQRTTGIFQMLAQLGKDEGINFKFGGKTGNTRDSHRLIQLGKTKGPQMQTRVIEELFAAYFENEKDITSHETLLEAAERAGLDKSEAKEWLDSDKGGPEVDKEVQDAYAQNIHGVPNFTINGKFEVGGAQEPAAFVQLFERLKRQDGGAVAMNSGSKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2023-06-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C7S2</accession>
    <name>A0A177C7S2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_937375</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG02899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033264.1">
        <property type="nucleotide sequence ID" value="XM_018187916.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C7S2"/>
    <dbReference type="GeneID" id="28771402"/>
    <dbReference type="InParanoid" id="A0A177C7S2"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG02899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="58" mass="6874" checksum="652B6CA8C4575716" modified="2016-09-07" version="1">MCHLLSIELEHRCMPFQWRSAQCTNKSDCCEVPREYADRCMEQRVTVLQSHSGHHLNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C859</accession>
    <name>A0A177C859_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ribosomal protein S14</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CC84DRAFT_1166738</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uS14 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG02958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033323.1">
        <property type="nucleotide sequence ID" value="XM_018179039.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C859"/>
    <dbReference type="FunCoup" id="A0A177C859">
        <property type="interactions" value="725"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177C859"/>
    <dbReference type="GeneID" id="28762525"/>
    <dbReference type="InParanoid" id="A0A177C859"/>
    <dbReference type="OrthoDB" id="10252683at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.830.10:FF:000002">
        <property type="entry name" value="40S ribosomal protein S29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.830.10">
        <property type="entry name" value="30s Ribosomal Protein S14, Chain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001209">
        <property type="entry name" value="Ribosomal_uS14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018271">
        <property type="entry name" value="Ribosomal_uS14_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039744">
        <property type="entry name" value="RIbosomal_uS14_euk_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043140">
        <property type="entry name" value="Ribosomal_uS14_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004424">
        <property type="entry name" value="PRK05766.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12010">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12010:SF2">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00253">
        <property type="entry name" value="Ribosomal_S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00527">
        <property type="entry name" value="RIBOSOMAL_S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAG02958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="56" mass="6573" checksum="D13B65AADB6752C0" modified="2016-09-07" version="1">MSHESVWYSRPRTYGKGSRECRVCTHPAGLIRKYGLNICRQCFREKSADIGFVKHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C8E6</accession>
    <name>A0A177C8E6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_1165996</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG03825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034190.1">
        <property type="nucleotide sequence ID" value="XM_018178848.1"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177C8E6"/>
    <dbReference type="GeneID" id="28762334"/>
    <dbReference type="InParanoid" id="A0A177C8E6"/>
    <dbReference type="OrthoDB" id="6375767at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005546">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051014">
        <property type="term" value="P:actin filament severing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008154">
        <property type="term" value="P:actin polymerization or depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051016">
        <property type="term" value="P:barbed-end actin filament capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025118">
        <property type="entry name" value="DUF4045"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057226">
        <property type="entry name" value="DUF7904"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007122">
        <property type="entry name" value="Villin/Gelsolin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11977:SF133">
        <property type="entry name" value="DUF4045 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11977">
        <property type="entry name" value="VILLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13254">
        <property type="entry name" value="DUF4045"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25480">
        <property type="entry name" value="DUF7904"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00262">
        <property type="entry name" value="GEL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4045" evidence="2">
        <location>
            <begin position="8"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7904" evidence="3">
        <location>
            <begin position="1248"/>
            <end position="1347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="749"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="853"/>
            <end position="1142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1161"/>
            <end position="1199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="247"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="264"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="352"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="395"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="435"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="478"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="541"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="568"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="631"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="658"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="673"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="752"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="896"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1004"/>
            <end position="1013"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1028"/>
            <end position="1037"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1089"/>
            <end position="1104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1116"/>
            <end position="1126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAG03825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="1621" mass="174611" checksum="E66435D64C9DAC20" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C8I3</accession>
    <name>A0A177C8I3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Ketopantoate reductase ApbA/PanE domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1166833</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG03067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033432.1">
        <property type="nucleotide sequence ID" value="XM_018179062.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C8I3"/>
    <dbReference type="GeneID" id="28762548"/>
    <dbReference type="InParanoid" id="A0A177C8I3"/>
    <dbReference type="OrthoDB" id="3753531at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG03067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="338" mass="37427" checksum="0B4707C5ED8A759F" modified="2016-09-07" version="1">MPTPKVLIVGCGAVGLSQGFHFSTGAEITYLVRPGRSAAFAPPKRLYDYKTDKLHTFENYRVIESTTDVAGEEFYCVFDTLDGHTAQSEGGVATLKSVGDLIRNAPKTFVIYDAVGADIEQHYASTMGISKERLVLAFSMLAHQPTPMISIPPTANRDLVAQADMLYSHLGADGGLAVVNKNGELTKKIEAVYNQNGRLKIQRQPAIVGDIVMIAMVQLVVWHIEGWPEWSRLPRSGESWTLLIRAQKEILSLPRFGWTGWILSWFLGSWVTAKMIEFPAKGASPLAYHEFNAFHHGGKVVQQDVQALEDLVAQGEKAKVKMDATQEICRQARKKLEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C8V7</accession>
    <name>A0A177C8V7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glycosyl transferase CAP10 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1151751</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG03292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033657.1">
        <property type="nucleotide sequence ID" value="XM_018176766.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C8V7"/>
    <dbReference type="GeneID" id="28760252"/>
    <dbReference type="InParanoid" id="A0A177C8V7"/>
    <dbReference type="OrthoDB" id="541052at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006598">
        <property type="entry name" value="CAP10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051091">
        <property type="entry name" value="O-Glucosyltr/Glycosyltrsf_90"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203:SF22">
        <property type="entry name" value="CAPSULE ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203">
        <property type="entry name" value="KDEL LYS-ASP-GLU-LEU CONTAINING - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05686">
        <property type="entry name" value="Glyco_transf_90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00672">
        <property type="entry name" value="CAP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase CAP10" evidence="2">
        <location>
            <begin position="318"/>
            <end position="613"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG03292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="633" mass="72324" checksum="AF43A77B3C401F32" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C8X7</accession>
    <name>A0A177C8X7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">lytic cellulose monooxygenase (C4-dehydrogenating)</fullName>
            <ecNumber evidence="15">1.14.99.56</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CC84DRAFT_1198197</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>[(1-&gt;4)-beta-D-glucosyl]n+m + reduced acceptor + O2 = 4-dehydro-beta-D-glucosyl-[(1-&gt;4)-beta-D-glucosyl]n-1 + [(1-&gt;4)-beta-D-glucosyl]m + acceptor + H2O.</text>
            <dbReference type="EC" id="1.14.99.56"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the polysaccharide monooxygenase AA9 family.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.56" evidence="15"/>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG03312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033677.1">
        <property type="nucleotide sequence ID" value="XM_018181552.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C8X7"/>
    <dbReference type="STRING" id="1460663.A0A177C8X7"/>
    <dbReference type="GeneID" id="28765038"/>
    <dbReference type="InParanoid" id="A0A177C8X7"/>
    <dbReference type="OrthoDB" id="6038816at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21175">
        <property type="entry name" value="LPMO_AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049892">
        <property type="entry name" value="AA9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005103">
        <property type="entry name" value="AA9_LPMO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353:SF10">
        <property type="entry name" value="ENDO-BETA-1,4-GLUCANASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03443">
        <property type="entry name" value="AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="8" id="KW-0186">Copper</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Auxiliary Activity family 9 catalytic" evidence="16">
        <location>
            <begin position="34"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00045077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF03443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="OAG03312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="277" mass="30187" checksum="0165A66B0363783E" modified="2016-09-07" version="1">MLSAFIYNRLRASAIVHILCKALVAALATTCYAHWTYDRIIVNGQVIGEPWQYVRRHSNGNNFLSDVTSNDMRCNINGGVSGSNTSTYAVQVGDLLGFTIRDTFGHPGPQQVYISKAPAAVKDYDGSGEWAKIYTLSNCVTKGCGTGDGIVKWATYRAQTFNFKLPAETPAGEYLLRAEGLAIHAAQKSKGAQFYVACAQIKVMGNGTGLPAPTIRIPGEYTENSTGILIPMIWSKITDYTSPGPRLWPEGTEEAHMLDGKVKESDSRLAIEDKVKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C8X9</accession>
    <name>A0A177C8X9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Carbonic anhydrase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CC84DRAFT_1206924</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="4">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the beta-class carbonic anhydrase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG03581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033946.1">
        <property type="nucleotide sequence ID" value="XM_018182068.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C8X9"/>
    <dbReference type="STRING" id="1460663.A0A177C8X9"/>
    <dbReference type="GeneID" id="28765554"/>
    <dbReference type="InParanoid" id="A0A177C8X9"/>
    <dbReference type="OrthoDB" id="10248475at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004089">
        <property type="term" value="F:carbonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1050.10">
        <property type="entry name" value="Carbonic anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001765">
        <property type="entry name" value="Carbonic_anhydrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036874">
        <property type="entry name" value="Carbonic_anhydrase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43175:SF3">
        <property type="entry name" value="CARBON DISULFIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43175">
        <property type="entry name" value="CARBONIC ANHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00947">
        <property type="entry name" value="Pro_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53056">
        <property type="entry name" value="beta-carbonic anhydrase, cab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="4">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR601765-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAG03581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="179" mass="19503" checksum="71321C933B4C2037" modified="2016-09-07" version="1">MTNPFPTIQDLAEKNAGASPGFKPKLTLQDLMSRNAMAVISCMDPRADPKDFWGIEAGMPPGVIRNAGGRAADALRSLEVLSALGEGLSAVAVVHHTHCGVGPHGIDDAYIKRTLPGRMRGSSSALEEKHWDSFKHQTEEESVREDMKLIVADKLLPKDVQVFGFVLDVETNRTTEVRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C9L6</accession>
    <name>A0A177C9L6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1206885</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG03529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033894.1">
        <property type="nucleotide sequence ID" value="XM_018182063.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C9L6"/>
    <dbReference type="STRING" id="1460663.A0A177C9L6"/>
    <dbReference type="GeneID" id="28765549"/>
    <dbReference type="InParanoid" id="A0A177C9L6"/>
    <dbReference type="OrthoDB" id="5409895at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010520">
        <property type="entry name" value="FrsA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050261">
        <property type="entry name" value="FrsA_esterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22946:SF12">
        <property type="entry name" value="CONIDIAL PIGMENT BIOSYNTHESIS PROTEIN AYG1 (AFU_ORTHOLOGUE AFUA_2G17550)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22946">
        <property type="entry name" value="DIENELACTONE HYDROLASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06500">
        <property type="entry name" value="FrsA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG03529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="420" mass="47667" checksum="761A9F0CD1EDB69F" modified="2016-09-07" version="1">MAAPGGKFFIQEKLGVKAAHHENYKQLWETKWKEPAEMGVYPFMFGTASDFEPVVAEMAARDMKEPYNWDEYAKIYFPQAEKLKGVAQEAESKGETEKASEYYLRSSAVYRISRFPAPRSEVQREAWKLGKECALKGLGLRPHPVSEVMIPHTHRLPHEGSHIPIYYMLPSSTTKDTPVPTIIIFTGLDGYRTELAVWMEGWRQNGVATIVLEIPGTGDCPADASDLKSPDRLYTSLFDWIGQQDGIDQKKVGIWAFSTGGYYAIRVAHTHADKLAGVVALGGGCHHMFDREWLDNVNHLEYPFDLANTLAYKWGYGDDVERFKDEAADKFSLLNDGTLDRPTCARLLLVNGTEDEIFPIDDYYLALQHGAPKEARFVQGVKHMGEPMSFFIIFNWFYKLFGIEADPVKQLQTLPFKPKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C9S7</accession>
    <name>A0A177C9S7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Iron sulfur cluster assembly protein 1, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CC84DRAFT_1148974</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; iron-sulfur cluster biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NifU family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG03507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033872.1">
        <property type="nucleotide sequence ID" value="XM_018176653.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C9S7"/>
    <dbReference type="FunCoup" id="A0A177C9S7">
        <property type="interactions" value="529"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177C9S7"/>
    <dbReference type="GeneID" id="28760139"/>
    <dbReference type="InParanoid" id="A0A177C9S7"/>
    <dbReference type="OrthoDB" id="1925777at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06664">
        <property type="entry name" value="IscU_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1010.10:FF:000005">
        <property type="entry name" value="Iron-sulfur cluster assembly protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1010.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002871">
        <property type="entry name" value="NIF_FeS_clus_asmbl_NifU_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10093">
        <property type="entry name" value="IRON-SULFUR CLUSTER ASSEMBLY ENZYME NIFU HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01592">
        <property type="entry name" value="NifU_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82649">
        <property type="entry name" value="SufE/NifU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NIF system FeS cluster assembly NifU N-terminal" evidence="8">
        <location>
            <begin position="5"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAG03507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="138" mass="14579" checksum="05F6EC00F88C327E" modified="2016-09-07" version="1">MSKADTDVGTGLVGAPACGDVMKLQIRVDPNNNTISDVKFKTFGCGSAIASSSYLTELVRGMTLEDAAKIRNTEIAKELCLPPVKLHCSMLAEDAIKSAISNYYTKNPNARKTDLGGTGSSLPKIEVETVTEPKAATV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C9W3</accession>
    <name>A0A177C9W3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_857739</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG03547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033912.1">
        <property type="nucleotide sequence ID" value="XM_018187642.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C9W3"/>
    <dbReference type="GeneID" id="28771128"/>
    <dbReference type="InParanoid" id="A0A177C9W3"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG03547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="202" mass="22860" checksum="A02AE562DCACE5C7" modified="2016-09-07" version="1">MQPELRDINTGTTLFSICYFSCVVVMMAFRNGPGPPQWRRVTMRSVRQRVETMCTRQEAAYQNRMARVNYLCDADVLAPFRYIRGLGAGMRQGADSRIRQTACCAAILHADRVGSVSILLSKRCYRNVVFVEQLSRASYVRHFSQLIHLIYPHPLLDVFGWKAPGGMIGKGMRPLGAEQPLEHPCGVAGRPLVWIITTMYCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CA24</accession>
    <name>A0A177CA24_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HET-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_895490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG04226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034591.1">
        <property type="nucleotide sequence ID" value="XM_018187817.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CA24"/>
    <dbReference type="STRING" id="1460663.A0A177CA24"/>
    <dbReference type="GeneID" id="28771303"/>
    <dbReference type="InParanoid" id="A0A177CA24"/>
    <dbReference type="OrthoDB" id="3486565at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF16">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="342"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG04226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="857" mass="96530" checksum="07F2B3DD8B9BD45A" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CAW1</accession>
    <name>A0A177CAW1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pyrroline-5-carboxylate reductase</fullName>
            <ecNumber evidence="5">1.5.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_1120650</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-proline + NADP(+) = (S)-1-pyrroline-5-carboxylate + NADPH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:14109"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17388"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="EC" id="1.5.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Amino-acid biosynthesis; L-proline biosynthesis; L-proline from L-glutamate 5-semialdehyde: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the pyrroline-5-carboxylate reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.2" evidence="5"/>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG04311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034676.1">
        <property type="nucleotide sequence ID" value="XM_018175585.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CAW1"/>
    <dbReference type="FunCoup" id="A0A177CAW1">
        <property type="interactions" value="440"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CAW1"/>
    <dbReference type="GeneID" id="28759071"/>
    <dbReference type="InParanoid" id="A0A177CAW1"/>
    <dbReference type="OrthoDB" id="10263291at2759"/>
    <dbReference type="UniPathway" id="UPA00098">
        <property type="reaction ID" value="UER00361"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004735">
        <property type="term" value="F:pyrroline-5-carboxylate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3730.10:FF:000001">
        <property type="entry name" value="Pyrroline-5-carboxylate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3730.10">
        <property type="entry name" value="ProC C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01925">
        <property type="entry name" value="P5C_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028939">
        <property type="entry name" value="P5C_Rdtase_cat_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053790">
        <property type="entry name" value="P5CR-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029036">
        <property type="entry name" value="P5CR_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000304">
        <property type="entry name" value="Pyrroline-COOH_reductase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00112">
        <property type="entry name" value="proC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11645">
        <property type="entry name" value="PYRROLINE-5-CARBOXYLATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11645:SF0">
        <property type="entry name" value="PYRROLINE-5-CARBOXYLATE REDUCTASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03807">
        <property type="entry name" value="F420_oxidored"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14748">
        <property type="entry name" value="P5CR_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000193">
        <property type="entry name" value="Pyrrol-5-carb_rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00521">
        <property type="entry name" value="P5CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2 4 5" id="KW-0521">NADP</keyword>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0641">Proline biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyrroline-5-carboxylate reductase catalytic N-terminal" evidence="6">
        <location>
            <begin position="13"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="Pyrroline-5-carboxylate reductase dimerisation" evidence="7">
        <location>
            <begin position="201"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="15"/>
            <end position="20"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>NADPH</name>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000193-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAG04311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="316" mass="32790" checksum="C4B14F0D53506F7E" modified="2016-09-07" version="1">MAAAQDSKGLTLTVLGSGTMGIAIMGGVMASLAAAKTQAALSDKPAAKDTPNLANFVACDAWAPAEEKVKAALGHYNFPLTTLTNNNLEGIQKGDVILLSCKPHIFKDILGEDGVRDALRGKVLVSILAGVTQEQIEGFLYPDGPPQDACRVVRVMPNTASFVRESMSVIQTSTPPLRPEQHKLVEFIFSSIGRVVTLPPALMDISTALCGSGPAFFALVLEAAADAGVAMGLPRAEAQIMAAQTMRGTTGLVLEGGEHPAILRDKVSTPGGCTIGGLLALEEGGVRGAFSRAVREATCVASQLGQGVKNVNGTRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CC59</accession>
    <name>A0A177CC59_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">60S ribosome subunit biogenesis protein NIP7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CC84DRAFT_1206054</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 7">Required for proper 27S pre-rRNA processing and 60S ribosome subunit assembly.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Interacts with pre-ribosome complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the NIP7 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG04348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034713.1">
        <property type="nucleotide sequence ID" value="XM_018182012.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CC59"/>
    <dbReference type="FunCoup" id="A0A177CC59">
        <property type="interactions" value="1042"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CC59"/>
    <dbReference type="GeneID" id="28765498"/>
    <dbReference type="InParanoid" id="A0A177CC59"/>
    <dbReference type="OrthoDB" id="27490at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902626">
        <property type="term" value="P:assembly of large subunit precursor of preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd21146">
        <property type="entry name" value="Nip7_N_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21151">
        <property type="entry name" value="PUA_Nip7-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.130.10:FF:000002">
        <property type="entry name" value="60S ribosome subunit biogenesis protein NIP7 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.220:FF:000001">
        <property type="entry name" value="60S ribosome subunit biogenesis protein NIP7 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.10">
        <property type="entry name" value="PUA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040598">
        <property type="entry name" value="NIP7_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055359">
        <property type="entry name" value="Nip7_N_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002478">
        <property type="entry name" value="PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036974">
        <property type="entry name" value="PUA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016686">
        <property type="entry name" value="Ribosomal_synth_fac_NIP7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005155">
        <property type="entry name" value="UPF0113_PUA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17833">
        <property type="entry name" value="pre-PUA_NIP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03657">
        <property type="entry name" value="UPF0113"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017190">
        <property type="entry name" value="Rbsml_synth_fac_NIP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00359">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88802">
        <property type="entry name" value="Pre-PUA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50890">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4 7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="PUA" evidence="8">
        <location>
            <begin position="97"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00054591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR017190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAG04348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="184" mass="20301" checksum="1575FF41B7E300A4" modified="2016-09-07" version="1">MRPLTEPETKTLFEKLAGYCGKGIQDLITAGGADDRHVFRIQGSRVYYVRESLANLATSVARDNLLSLGTCLGKFTKTGKFRLHITALAVIAPHARYKVWVKPNGEMPFLYGGNVLKAHVGRWSEDCPEHQGVIVLSMSDTPLGFGVSARSTAEARKLDPTGVVTFRQADIGEYLREEDTLFQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CDD0</accession>
    <name>A0A177CDD0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1093040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG04892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035257.1">
        <property type="nucleotide sequence ID" value="XM_018174500.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CDD0"/>
    <dbReference type="GeneID" id="28757986"/>
    <dbReference type="InParanoid" id="A0A177CDD0"/>
    <dbReference type="OrthoDB" id="3768980at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG04892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="88" mass="10018" checksum="854C985565051C6E" modified="2016-09-07" version="1">MAYERFISPGPSVATLWTRYYFSLKAHALIGDILDLDEEKDAAKLLDGNINTVWCAAILYQFCWDKQVNACKRPLRYSKGHGSIVVSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CDW4</accession>
    <name>A0A177CDW4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1164268</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG05824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036189.1">
        <property type="nucleotide sequence ID" value="XM_018178456.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CDW4"/>
    <dbReference type="GeneID" id="28761942"/>
    <dbReference type="InParanoid" id="A0A177CDW4"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG05824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="58" mass="6782" checksum="A0742273B960F165" modified="2016-09-07" version="1">MHAVAEETRLECIGCSYAPRTHFLSSKHPKPHLLRHTGRASSLRTYWNAWNMENLEMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CED2</accession>
    <name>A0A177CED2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD-dependent epimerase/dehydratase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_1164398</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG05993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036358.1">
        <property type="nucleotide sequence ID" value="XM_018178479.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CED2"/>
    <dbReference type="STRING" id="1460663.A0A177CED2"/>
    <dbReference type="GeneID" id="28761965"/>
    <dbReference type="InParanoid" id="A0A177CED2"/>
    <dbReference type="OrthoDB" id="16464at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05238">
        <property type="entry name" value="Gne_like_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050005">
        <property type="entry name" value="DenD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF043036">
        <property type="entry name" value="ErythonDh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43103:SF3">
        <property type="entry name" value="ADP-L-GLYCERO-D-MANNO-HEPTOSE-6-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43103">
        <property type="entry name" value="NUCLEOSIDE-DIPHOSPHATE-SUGAR EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="3">
        <location>
            <begin position="3"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAG05993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="315" mass="33935" checksum="B80EA7A35216F885" modified="2016-09-07" version="1">MKVIITGAGGFVGQTLAKKLIETSPDTELILADVQAPPNPTKSDKVECIGADLTNADTRKALIDHAPDAVYILHGIMSSGSEANLELGLSVNFDSVRGLLDAIREKKSGTKVIFTSSCAVFGRAAVKNVATETDIVPMPESSYGTQKLMVEYLVNDYSRRGLIDGRVVRLPTIFVRAGAPTAAASSFVSGIVREPVHGQESELPVDPNIGIWLASPRTLAHNLVHAMNVPAEKLGHFRTVLLPGYTATSGEILEALEKVAGKETRALVKEKRDEKIEKIVLSWPGKYDTSRAKELGFSEDVGLEQTIRDFIAGEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CEM6</accession>
    <name>A0A177CEM6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phosphoribulokinase/uridine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1187116</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG06085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036450.1">
        <property type="nucleotide sequence ID" value="XM_018180904.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CEM6"/>
    <dbReference type="FunCoup" id="A0A177CEM6">
        <property type="interactions" value="6"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CEM6"/>
    <dbReference type="GeneID" id="28764390"/>
    <dbReference type="InParanoid" id="A0A177CEM6"/>
    <dbReference type="OrthoDB" id="6362633at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10285">
        <property type="entry name" value="URIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG06085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="244" mass="26228" checksum="75FDC1AD4D872636" modified="2016-09-07" version="1">MAQDTTVHAVPASSLKSTILHLAKRVEALLARQASSDTPSRILVALAGVPGSGKSTVSAALLVELAARGIADVAVVPMDGFHLTKKQLSALPNSEEAFARRGAPFTFDAPSFLSLVQSLAVTPLPTPSSPSPETFLYAPSFDHALQDPVKDGIPISSRTRLIIVEGNYVLLDEEPWRDVAALCAEKWFVDTPRKVVLERLVGRHLAAGIETDVEEAVKRVEANDLPNGDVIRERLIIPDVMVEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CER5</accession>
    <name>A0A177CER5_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_1092358</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG05806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036171.1">
        <property type="nucleotide sequence ID" value="XM_018174449.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CER5"/>
    <dbReference type="STRING" id="1460663.A0A177CER5"/>
    <dbReference type="GeneID" id="28757935"/>
    <dbReference type="InParanoid" id="A0A177CER5"/>
    <dbReference type="OrthoDB" id="3162524at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000039">
        <property type="entry name" value="Neutral amino acid transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF694">
        <property type="entry name" value="AMINO ACID PERMEASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="127"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="158"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="181"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="230"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="266"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="308"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="348"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="374"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="415"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="7">
        <location>
            <begin position="44"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAG05806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="464" mass="50105" checksum="DFD1BD87F1D8CAEA" modified="2016-09-07" version="1">MSTEKSHDMIEPAPSNDQVSIEKIDLENDGEIFKRGEGYEDFRTVGWIQTTIIFTKLIFATGVLTIPSAMYTLGAFPGAINVLGWQFLNTYCAQVQGQFRHNHAGCHSIADMGNLVGGKIVRELTGILFLVAFILVGASGIVGTSTALNALSNHSLCTNYFSIIATIMVFVAGSPRKFEKIAWVTWAGFLSVFIAIFIVVVGVTTLDRPAAAPQTGDFDFGYHVIGHPTFAAGMVAASTIFCSGAGTGAFLPVMSEMKNPKDYKKAVNWCMGFVTAAYLTFSIVVYWYCGKWVASPSLGSAGPLIKKIAYGIGILGLMVSGALFNHVSAKYIFVRVLRDSKHLQANSLVHWGVWLGTLAAVNLVAFLIASGVPIFNYLLSLAGSLAFAPLALGLPGWLWIYDHKDYRKGTLIQKILYGLHVLMIMISLFLCIGGTYGVIVQIMDAYKDGSIDSAFSCADNSNSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CET7</accession>
    <name>A0A177CET7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein eL39</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">60S ribosomal protein L39</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CC84DRAFT_1145347</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL39 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG05731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036096.1">
        <property type="nucleotide sequence ID" value="XM_018176503.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CET7"/>
    <dbReference type="FunCoup" id="A0A177CET7">
        <property type="interactions" value="329"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CET7"/>
    <dbReference type="GeneID" id="28759989"/>
    <dbReference type="InParanoid" id="A0A177CET7"/>
    <dbReference type="OrthoDB" id="6332053at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030684">
        <property type="term" value="C:preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1620.10:FF:000001">
        <property type="entry name" value="60S ribosomal protein-like L39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1620.10">
        <property type="entry name" value="Ribosomal protein L39e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00629">
        <property type="entry name" value="Ribosomal_eL39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000077">
        <property type="entry name" value="Ribosomal_eL39"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023626">
        <property type="entry name" value="Ribosomal_eL39_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19970:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19970">
        <property type="entry name" value="RIBOSOMAL PROTEIN L39E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00832">
        <property type="entry name" value="Ribosomal_L39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48662">
        <property type="entry name" value="Ribosomal protein L39e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAG05731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="51" mass="6253" checksum="4E9DD7E424D7A5D6" modified="2016-09-07" version="1">MPSHKSFRTKQKLAKAQKQNRPIPQWIRLRTGNTIRYNAKRRHWRKTRIGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CF00</accession>
    <name>A0A177CF00_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal protein/NADH dehydrogenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CC84DRAFT_1165584</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG05290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035655.1">
        <property type="nucleotide sequence ID" value="XM_018178752.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CF00"/>
    <dbReference type="STRING" id="1460663.A0A177CF00"/>
    <dbReference type="GeneID" id="28762238"/>
    <dbReference type="InParanoid" id="A0A177CF00"/>
    <dbReference type="OrthoDB" id="1696305at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007741">
        <property type="entry name" value="Ribosomal_mL43/mS25/NADH_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040049">
        <property type="entry name" value="Ribosomal_mS25/mL61"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13274">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOMAL PROTEIN S25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13274:SF2">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00916">
        <property type="entry name" value="L51_S25_CI-B8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal protein/NADH dehydrogenase" evidence="6">
        <location>
            <begin position="41"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="86"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="87"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAG05290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="192" mass="21905" checksum="B1F16BB688438E80" modified="2016-09-07" version="1">MVNMLKRMRKLRELLWIRNGPGAIQLPKEVTKISVEFHKKLIGSQHRGARHFWHDILPRIKYRNPTLPISVIRHADPAGPAYLNIYTSTPTPQTSTTPPPSTTTAPEALNDTPTHTIEIKDLHESEILEALVEKTGAVVLRTPPEEAAEMAEIEEFKERAEVDRVEVREKLMKVRREEELLKLARGEISAQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CF35</accession>
    <name>A0A177CF35_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pyruvate decarboxylase</fullName>
            <ecNumber evidence="4">4.1.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CC84DRAFT_1164530</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2-oxocarboxylate + H(+) = an aldehyde + CO2</text>
            <dbReference type="Rhea" id="RHEA:11628"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:35179"/>
            <dbReference type="EC" id="4.1.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="11">Binds 1 Mg(2+) per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the TPP enzyme family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.1" evidence="4"/>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG06215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036580.1">
        <property type="nucleotide sequence ID" value="XM_018178504.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CF35"/>
    <dbReference type="STRING" id="1460663.A0A177CF35"/>
    <dbReference type="GeneID" id="28761990"/>
    <dbReference type="InParanoid" id="A0A177CF35"/>
    <dbReference type="OrthoDB" id="3970464at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004737">
        <property type="term" value="F:pyruvate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000949">
        <property type="term" value="P:aromatic amino acid family catabolic process to alcohol via Ehrlich pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02005">
        <property type="entry name" value="TPP_PDC_IPDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07038">
        <property type="entry name" value="TPP_PYR_PDC_IPDC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000019">
        <property type="entry name" value="Pyruvate decarboxylase isozyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000024">
        <property type="entry name" value="Pyruvate decarboxylase isozyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012110">
        <property type="entry name" value="PDC/IPDC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme_TPP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047214">
        <property type="entry name" value="TPP_PDC_IPDC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047213">
        <property type="entry name" value="TPP_PYR_PDC_IPDC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43452">
        <property type="entry name" value="PYRUVATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43452:SF11">
        <property type="entry name" value="PYRUVATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036565">
        <property type="entry name" value="Pyruvt_ip_decrb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="10" id="KW-0456">Lyase</keyword>
    <keyword evidence="8 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 12" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="Thiamine pyrophosphate enzyme N-terminal TPP-binding" evidence="15">
        <location>
            <begin position="6"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme central" evidence="13">
        <location>
            <begin position="201"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme TPP-binding" evidence="14">
        <location>
            <begin position="396"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="449"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="476"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="478"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR036565-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OAG06215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="570" mass="62665" checksum="E20F936394B40129" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CFN4</accession>
    <name>A0A177CFN4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1164224</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG05762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036127.1">
        <property type="nucleotide sequence ID" value="XM_018178446.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CFN4"/>
    <dbReference type="GeneID" id="28761932"/>
    <dbReference type="InParanoid" id="A0A177CFN4"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG05762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="184" mass="20664" checksum="BA86AF7A6BA8E050" modified="2016-09-07" version="1">MYIHPRAYARSPRAAPYHPKSQSQSALPAPPTCPPYDRLTPQAAPSASVGKARLEAHGRHTLPARPALGLDRLSAPLYLHVRVYLRVSGLAGLGREFFLHMYRTRDVGCLPPHVECVRQGDAYRRERHHCLLYTALESKVSGSGCVCFGMGFRPRRVGPARAGRYLPTLRPWSRVEWRLSHVHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CGD7</accession>
    <name>A0A177CGD7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Enoyl-CoA hydratase/carnithine racemase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1074284</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Mycotoxin biosynthesis.</text>
    </comment>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG05820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036185.1">
        <property type="nucleotide sequence ID" value="XM_018173696.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CGD7"/>
    <dbReference type="STRING" id="1460663.A0A177CGD7"/>
    <dbReference type="GeneID" id="28757182"/>
    <dbReference type="InParanoid" id="A0A177CGD7"/>
    <dbReference type="OrthoDB" id="410701at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43459:SF1">
        <property type="entry name" value="EG:BACN32G11.4 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43459">
        <property type="entry name" value="ENOYL-COA HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0843">Virulence</keyword>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG05820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="261" mass="28126" checksum="03DDE39A7CC5FF4B" modified="2016-09-07" version="1" fragment="single">ITLTKVTPSYWRASFSSPPFNIQTNAWYTALYTLITDLTTDPAVKVVVFDSSVPDFYIAHFDLLSPVDNSLIDGFWPNITQLANLPVLSVAAVNGIAHGGGAEFAAAMDVRFASREKAVFGQLEVGLGSLPGGGGLSLLPRLVGRSIALEIVLGGQDFDADTAAAYGWVNRAIPDAEFDGFIDTFARRVSSFDKSAILEAKRIINKRAGYPTVDEQAEDWNAALGLLATPNVQARVAKMVELGLQKDTDYELNVAEKLLDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2023-06-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CGP2</accession>
    <name>A0A177CGP2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1259312</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG06009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036374.1">
        <property type="nucleotide sequence ID" value="XM_018184901.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CGP2"/>
    <dbReference type="GeneID" id="28768387"/>
    <dbReference type="InParanoid" id="A0A177CGP2"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG06009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="225" mass="24957" checksum="9A3492AA69FC3416" modified="2016-09-07" version="1" fragment="single">HRPNYELLDTRTQAAPWSSLTSSHFPHVKTLLKRAQPARVARALPLDSAPVNTPATPNERLIPRLWQDGSVTTSSPGKTNILLPNLITKRDHGPALAHRLGHNRPAPQRHGHNRLLAGRAHLQQLQPLHPGRFHRRRVGPRAPLRPRLLHGARPRQKGFAPAPRLNYLPAVSRVRTRWPYWRGRRSPATASVSSRVDAAAHACPAHGLGRGGGGRRTALCGKQRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CGQ9</accession>
    <name>A0A177CGQ9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CC84DRAFT_1196234</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG06029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036394.1">
        <property type="nucleotide sequence ID" value="XM_018181444.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CGQ9"/>
    <dbReference type="GeneID" id="28764930"/>
    <dbReference type="InParanoid" id="A0A177CGQ9"/>
    <dbReference type="OrthoDB" id="6770063at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015174">
        <property type="term" value="F:basic amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF33">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="71"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="161"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="229"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="268"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="294"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="336"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="373"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="403"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="432"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="459"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="541"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="71"/>
            <end position="568"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAG06029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="568" mass="59605" checksum="B5ED3E367444C6CA" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CH90</accession>
    <name>A0A177CH90_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_609188</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG06591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036956.1">
        <property type="nucleotide sequence ID" value="XM_018186872.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CH90"/>
    <dbReference type="STRING" id="1460663.A0A177CH90"/>
    <dbReference type="GeneID" id="28770358"/>
    <dbReference type="InParanoid" id="A0A177CH90"/>
    <dbReference type="OrthoDB" id="5309037at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42354">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42354:SF1">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="212"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="367"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG06591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="414" mass="45771" checksum="6603FF3662487778" modified="2016-09-07" version="1">MGAAPMVDPANVVQALVNTLLDVFDATRDLYQTLKSKQRRDYEHNLRSRGYRRSLDHVDDGPDGEEEIIMDKAAVLRTFDVGLDEVGTQFAVGDVISQAGLQSQIIVLQSAIITTFLYGPTSPEPISHHLKTLLAASREAGTTAVDILSAQQQRQLAVLSPTPRAGRSRAGSMKAPPYPMTATSSVSTALVRSRQEPPDEYSRTVHPAKTTILSRPPVPRTDTESTAFSGPTSYGTETSLHSNFCLYALDLQRHASQPLASTISSDPSPYCPYCKRSLHLSPGRSWEIFKDDGARERCFHVQNRFVVKCHREGVDGGYSCVVCATSASHETVCGDVNALVKHVWQDHTIGELKAEQDIVELVEKTPERRRDSVMAPPNHSRRSFSLGPSRSGRRRVEREVETLEIRAPRRERDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CHI8</accession>
    <name>A0A177CHI8_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Azaphilone pigments biosynthesis cluster protein L N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_1217468</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG06207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036572.1">
        <property type="nucleotide sequence ID" value="XM_018182895.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CHI8"/>
    <dbReference type="GeneID" id="28766381"/>
    <dbReference type="InParanoid" id="A0A177CHI8"/>
    <dbReference type="OrthoDB" id="432483at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031348">
        <property type="entry name" value="PigL_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17111">
        <property type="entry name" value="PigL_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008058193" description="Azaphilone pigments biosynthesis cluster protein L N-terminal domain-containing protein" evidence="2">
        <location>
            <begin position="25"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="Azaphilone pigments biosynthesis cluster protein L N-terminal" evidence="3">
        <location>
            <begin position="2"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="363"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="371"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="394"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAG06207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="414" mass="45642" checksum="94974B0B60C7AE28" modified="2016-09-07" version="1">MADPLSITASVLAIVTAAVQSVKSLNDTVSRYKGRDRTLQRLQNELRDVCGILDSLKEAIQAEASVSALLKGPVGRCGDICQEFEQSMRSFNEKSKTGVRDWAKLEFMRGDINEFIDTISGYKSTIALGLGLITIRAAKVSQEAWKEYNELIQDTVHDLNIHLQRVDEKLEGFSNPSSSPSSVNLGDEKEVTKQCLQICEGAKQFLESSRKSSVLEETLDATHDPHHDRFEAQVLTRQALDENRDSFLKIIGLLRNRLESLILENNPEGGKERSRLLDDINASKQCLEICKAASEASSQKVYRVGEAIADGDSDQVVANTLADLFDVKRAVSKDRSAQLIGSMSGEELRFLAEKRYESRFGAVAPETSSATSTPVVNTEEETSSTPPLTGLTPHAQSVHTSEKPSSNEIRKRII</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CHJ6</accession>
    <name>A0A177CHJ6_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">1-phosphatidylinositol-3-phosphate 5-kinase</fullName>
            <ecNumber evidence="1">2.7.1.150</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CC84DRAFT_1142851</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.1.150" evidence="1"/>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG06796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037161.1">
        <property type="nucleotide sequence ID" value="XM_018176382.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A177CHJ6">
        <property type="interactions" value="806"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CHJ6"/>
    <dbReference type="GeneID" id="28759868"/>
    <dbReference type="InParanoid" id="A0A177CHJ6"/>
    <dbReference type="OrthoDB" id="158357at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000285">
        <property type="term" value="F:1-phosphatidylinositol-3-phosphate 5-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03334">
        <property type="entry name" value="Fab1_TCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17300">
        <property type="entry name" value="PIPKc_PIKfyve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.810.10:FF:000001">
        <property type="entry name" value="1-phosphatidylinositol 3-phosphate 5-kinase FAB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000007">
        <property type="entry name" value="1-phosphatidylinositol 3-phosphate 5-kinase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000283">
        <property type="entry name" value="1-phosphatidylinositol-3-phosphate 5-kinase (Fab1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.810.10">
        <property type="entry name" value="2-Layer Sandwich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.800.10">
        <property type="entry name" value="Phosphatidylinositol Phosphate Kinase II Beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044769">
        <property type="entry name" value="PIKfyve_PIPKc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027483">
        <property type="entry name" value="PInositol-4-P-4/5-kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002498">
        <property type="entry name" value="PInositol-4-P-4/5-kinase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027484">
        <property type="entry name" value="PInositol-4-P-5-kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45748">
        <property type="entry name" value="1-PHOSPHATIDYLINOSITOL 3-PHOSPHATE 5-KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45748:SF7">
        <property type="entry name" value="1-PHOSPHATIDYLINOSITOL 3-PHOSPHATE 5-KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01504">
        <property type="entry name" value="PIP5K"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00330">
        <property type="entry name" value="PIPKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56104">
        <property type="entry name" value="SAICAR synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51455">
        <property type="entry name" value="PIPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FYVE-type" evidence="12">
        <location>
            <begin position="397"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="PIPK" evidence="13">
        <location>
            <begin position="1986"/>
            <end position="2308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="115"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="357"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="458"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="644"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1513"/>
            <end position="1593"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1614"/>
            <end position="1655"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1695"/>
            <end position="1740"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1760"/>
            <end position="1780"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1856"/>
            <end position="1907"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="134"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="151"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="170"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="200"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="215"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="461"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="477"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="529"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="545"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="710"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="727"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1537"/>
            <end position="1549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1701"/>
            <end position="1714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1763"/>
            <end position="1777"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1856"/>
            <end position="1867"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1876"/>
            <end position="1887"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1888"/>
            <end position="1897"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OAG06796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="2364" mass="263261" checksum="D884D63253F49572" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CI67</accession>
    <name>A0A177CI67_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CC84DRAFT_1142454</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG06558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036923.1">
        <property type="nucleotide sequence ID" value="XM_018176370.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CI67"/>
    <dbReference type="STRING" id="1460663.A0A177CI67"/>
    <dbReference type="GeneID" id="28759856"/>
    <dbReference type="InParanoid" id="A0A177CI67"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11065">
        <property type="entry name" value="CYP64-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF7">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008058228" evidence="10">
        <location>
            <begin position="19"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="440"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OAG06558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="528" mass="59739" checksum="16A6FB9BA04AC25A" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CIR7</accession>
    <name>A0A177CIR7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative flavin-containing monooxygenase YUCCA3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CC84DRAFT_1090000</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG06677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037042.1">
        <property type="nucleotide sequence ID" value="XM_018174335.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CIR7"/>
    <dbReference type="GeneID" id="28757821"/>
    <dbReference type="InParanoid" id="A0A177CIR7"/>
    <dbReference type="OrthoDB" id="74360at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050982">
        <property type="entry name" value="Auxin_biosynth/cation_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43539:SF24">
        <property type="entry name" value="FAD_NAD(P)-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43539">
        <property type="entry name" value="FLAVIN-BINDING MONOOXYGENASE-LIKE PROTEIN (AFU_ORTHOLOGUE AFUA_4G09220)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="164"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAG06677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="626" mass="69166" checksum="736177C4C806452A" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CJF3</accession>
    <name>A0A177CJF3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Peroxisomal d3,d2-enoyl-CoA isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_1163208</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism; fatty acid beta-oxidation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Mycotoxin biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG06917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037282.1">
        <property type="nucleotide sequence ID" value="XM_018178204.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CJF3"/>
    <dbReference type="STRING" id="1460663.A0A177CJF3"/>
    <dbReference type="GeneID" id="28761690"/>
    <dbReference type="InParanoid" id="A0A177CJF3"/>
    <dbReference type="OrthoDB" id="448450at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005782">
        <property type="term" value="C:peroxisomal matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000048">
        <property type="entry name" value="3,2-trans-enoyl-CoA isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051053">
        <property type="entry name" value="ECH/Chromodomain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43684">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43684:SF3">
        <property type="entry name" value="PEROXISOMAL D3,D2-ENOYL-COA ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0843">Virulence</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAG06917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="279" mass="30821" checksum="8119BBBAD0D2AECF" modified="2016-09-07" version="1">MAPQYNDIKFEVKGKIGVIKFNRPKALNSFGGTLISDVIAALRELNEHPDTVFTVLTGEGRFFSAGADVRGGSLSQQPKEFKNAGEKKLAFLQNFTYALELLRSMIDHRKVLILALNGPGVGGGAAWFPGIADIVLASSSAWLQCPFSALALVPENGSALSFAQHIGIHRANDFLMFGRKLSAQELLDAGMYNYVWDKSGDEFHAEVIKFLEGQLEVNDGKSMMETKRLQNVGVRDQRMIAVVNAVDALAERFVEDAPLHRFAEKKKLMEEKSKTRSKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CJI4</accession>
    <name>A0A177CJI4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ATP synthase subunit 5, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CC84DRAFT_1186060</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATPase delta chain family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG06947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037312.1">
        <property type="nucleotide sequence ID" value="XM_018180837.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CJI4"/>
    <dbReference type="FunCoup" id="A0A177CJI4">
        <property type="interactions" value="681"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CJI4"/>
    <dbReference type="GeneID" id="28764323"/>
    <dbReference type="InParanoid" id="A0A177CJI4"/>
    <dbReference type="OrthoDB" id="1262810at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.520.20">
        <property type="entry name" value="N-terminal domain of the delta subunit of the F1F0-ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01416">
        <property type="entry name" value="ATP_synth_delta_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026015">
        <property type="entry name" value="ATP_synth_OSCP/delta_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020781">
        <property type="entry name" value="ATPase_OSCP/d_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000711">
        <property type="entry name" value="ATPase_OSCP/dsu"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01145">
        <property type="entry name" value="ATP_synt_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11910">
        <property type="entry name" value="ATP SYNTHASE DELTA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00213">
        <property type="entry name" value="OSCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00125">
        <property type="entry name" value="ATPASEDELTA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47928">
        <property type="entry name" value="N-terminal domain of the delta subunit of the F1F0-ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00389">
        <property type="entry name" value="ATPASE_DELTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAG06947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="232" mass="24280" checksum="CB13DBC78F2C7E56" modified="2016-09-07" version="1">MFSSRALTSAARIAAPRPQIAARVVATRAYAAAAAPSTGAANKPPVALFGIDGTYASALYTAAAKTNALDSAAKSLDSLAAVFKKDAKLATILTAPTLSVSDKQQIVAELQKHLGNDKDGIVKNLLDTLAQNNRLGALEGVVDKFGQLMSAYRGEVELTVTSAAPLDNRTLSRLESAVSKSSYVSSGQKLKVVPKVNPDIRGGLIVEIGDRTIDLSVSAKMARMNKLLKDTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CJP4</accession>
    <name>A0A177CJP4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1258565</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG07471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037836.1">
        <property type="nucleotide sequence ID" value="XM_018184838.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CJP4"/>
    <dbReference type="STRING" id="1460663.A0A177CJP4"/>
    <dbReference type="GeneID" id="28768324"/>
    <dbReference type="InParanoid" id="A0A177CJP4"/>
    <dbReference type="OrthoDB" id="3692311at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="180"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="234"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="159"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG07471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="314" mass="32355" checksum="47314863D43144FE" modified="2016-09-07" version="1">MPRRQDATAAQLSFSPTCPSGGTWQVCGSNFAGCCAGDACTRSGCVEGNLYPVAFDSTQHGEFPDASCGLGISFWTCGFGPTFWGCCKTNPCAAGAVCPRGDLAAAHANGGDPVQQAYYLGGSSGPISITSASPSATSTSTNTGTLVTSIASLNSLGGSTSSPTTTPVASSPQPASHTAAIAGGSAAGGVFVALLVCWLIYYLCYVKRSRKIHNDALSSLQSDLPVATMTEKPDNATTATQGYDAAPPGYCSPNPSTYPHQRNEVSSYVYPHATANPAAWKPQHRHGLSELSEETVWRSELESPVPSPRVGCTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CK50</accession>
    <name>A0A177CK50_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">E3 ubiquitin-protein ligase</fullName>
            <ecNumber evidence="9">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CC84DRAFT_1163391</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 9">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the RSP5/NEDD4 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="9"/>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG07167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037532.1">
        <property type="nucleotide sequence ID" value="XM_018178255.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CK50"/>
    <dbReference type="FunCoup" id="A0A177CK50">
        <property type="interactions" value="580"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CK50"/>
    <dbReference type="GeneID" id="28761741"/>
    <dbReference type="InParanoid" id="A0A177CK50"/>
    <dbReference type="OrthoDB" id="8068875at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072666">
        <property type="term" value="P:establishment of protein localization to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd08382">
        <property type="entry name" value="C2_Smurf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00078">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.10:FF:000011">
        <property type="entry name" value="E3 ubiquitin-protein ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.10:FF:000017">
        <property type="entry name" value="E3 ubiquitin-protein ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000074">
        <property type="entry name" value="E3 ubiquitin-protein ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1750.10:FF:000005">
        <property type="entry name" value="E3 ubiquitin-protein ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2160.10:FF:000001">
        <property type="entry name" value="E3 ubiquitin-protein ligase NEDD4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2410.10:FF:000001">
        <property type="entry name" value="E3 ubiquitin-protein ligase NEDD4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024928">
        <property type="entry name" value="E3_ub_ligase_SMURF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050409">
        <property type="entry name" value="E3_ubiq-protein_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254:SF440">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE NEDD-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254">
        <property type="entry name" value="HECT DOMAIN UBIQUITIN-PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001569">
        <property type="entry name" value="E3_ub_ligase_SMURF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 9 11" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="C2" evidence="13">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="14">
        <location>
            <begin position="229"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="14">
        <location>
            <begin position="329"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="14">
        <location>
            <begin position="388"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="domain" description="HECT" evidence="15">
        <location>
            <begin position="477"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="136"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="259"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="136"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="163"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="181"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="270"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="295"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="320"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="10 11">
        <location>
            <position position="778"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR001569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001569-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OAG07167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="810" mass="92023" checksum="6832AE3CDD22E0B7" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CM29</accession>
    <name>A0A177CM29_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1203914</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038938.1">
        <property type="nucleotide sequence ID" value="XM_018181861.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CM29"/>
    <dbReference type="GeneID" id="28765347"/>
    <dbReference type="InParanoid" id="A0A177CM29"/>
    <dbReference type="OrthoDB" id="9986966at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00161">
        <property type="entry name" value="beta-trefoil_Ricin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="Ricin B-like lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG08573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="190" mass="20948" checksum="4DAFF88A7B07F087" modified="2016-09-07" version="1">MTTQYLTNSYLGPAYSLQPNHSSSIPSGVHCAPSRNGGLLWTLVPTPEDPTKFNICTTDPQSRQPKCLDIYNDNSSDRTRVRLADPGHYAGQMWTLISQREPGYFKLSNDWTGEGWYLDTYSDSYEAFMSQGDATGQYWAIQGVGSGSGAHTVPVQTYDDNHHHCYDQAGKIAGGAAAGYLGKKLWKKLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CNK8</accession>
    <name>A0A177CNK8_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Post-GPI attachment to proteins factor 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_1162430</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in the lipid remodeling steps of GPI-anchor maturation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Endoplasmic reticulum membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the PGAP3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038845.1">
        <property type="nucleotide sequence ID" value="XM_018177994.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CNK8"/>
    <dbReference type="FunCoup" id="A0A177CNK8">
        <property type="interactions" value="185"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CNK8"/>
    <dbReference type="GeneID" id="28761480"/>
    <dbReference type="InParanoid" id="A0A177CNK8"/>
    <dbReference type="OrthoDB" id="419770at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030026">
        <property type="term" value="P:intracellular manganese ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007217">
        <property type="entry name" value="Per1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13148">
        <property type="entry name" value="PER1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13148:SF0">
        <property type="entry name" value="POST-GPI ATTACHMENT TO PROTEINS FACTOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04080">
        <property type="entry name" value="Per1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="2 7" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016487318" description="Post-GPI attachment to proteins factor 3" evidence="7">
        <location>
            <begin position="25"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="141"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="172"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="203"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="229"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="262"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="294"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAG08480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="326" mass="38269" checksum="A26282125018C21A" modified="2016-09-07" version="1">MRMRNVSAWRTAALLVLLSGTAYASLGDRLPEFKDCLKVCHEANCGVDATPIPIHRRLLLWDCPAECDYSCQHIVTDKRLARDPPYMRPVYQFHGKWPFYRFLGMQEPFSVIFSLFNYLAHSWGQAQIREKIPPSYAIRKYYIAFGYFGMASWMFSMIFHTRDYNLTEKLDYFAAGAQVLYGMYMAAIRIFRLERKEPMRQSVLRVWTTTCIILYTLHVTYLTLWKWDYTYNMAANVAVGVVQNLLWSGFSFTQYRKVGRTWAMWPGFIVAWILVAMSMELLDFPPWKGMLDAHSLWHLGTVVPTIWWYNFLIKDAQEDLAGPRKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CNZ3</accession>
    <name>A0A177CNZ3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1162582</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039067.1">
        <property type="nucleotide sequence ID" value="XM_018178028.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CNZ3"/>
    <dbReference type="GeneID" id="28761514"/>
    <dbReference type="InParanoid" id="A0A177CNZ3"/>
    <dbReference type="OrthoDB" id="3001700at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG08702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="103" mass="10807" checksum="1520580B62F4DB2B" modified="2016-09-07" version="1">MTTSKFFTVLAGIVSVLALAVYLFGIPPEVKRKLERSALKTMGENKLSYIAKDQISKIPASDQENVKDLKKGLGNAVGGLASNPLGEATGEAADSLTSPLTGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CPQ2</accession>
    <name>A0A177CPQ2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_439256</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG09503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039868.1">
        <property type="nucleotide sequence ID" value="XM_018186276.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CPQ2"/>
    <dbReference type="GeneID" id="28769762"/>
    <dbReference type="InParanoid" id="A0A177CPQ2"/>
    <dbReference type="OrthoDB" id="10463824at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG09503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="151" mass="15991" checksum="AD7D73E85AEAD10C" modified="2016-09-07" version="1">MILRGTLSAPTSRRGEIVSRFCAGTAISSISLLYGTKPGPRLPALWVLCGLEDIAQLGAVDAGSQANSWPRGRVLSRVDARAMAVPDCTLSVPFLPGSFSAGHCPVASSARSIVGLGYISIVPVGQQLTRFLSRICFTREKLENHTCAVFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CPS4</accession>
    <name>A0A177CPS4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CC84DRAFT_1160483</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG09306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039671.1">
        <property type="nucleotide sequence ID" value="XM_018177509.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CPS4"/>
    <dbReference type="STRING" id="1460663.A0A177CPS4"/>
    <dbReference type="GeneID" id="28760995"/>
    <dbReference type="InParanoid" id="A0A177CPS4"/>
    <dbReference type="OrthoDB" id="2590011at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090575">
        <property type="term" value="C:RNA polymerase II transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050936">
        <property type="entry name" value="AP-1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40621:SF6">
        <property type="entry name" value="AP-1-LIKE TRANSCRIPTION FACTOR YAP1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40621">
        <property type="entry name" value="TRANSCRIPTION FACTOR KAPC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="4">
        <location>
            <begin position="24"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="132"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="238"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="11"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="134"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="156"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="172"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="242"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAG09306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="337" mass="37470" checksum="7A9656070C952E63" modified="2016-09-07" version="1">MVKFTFKPFKSQKSPADSASEEPQNAYQKRREQVRRAQKTHRERKEAYVKSLESEVIQLRANEARLFQETKTLYAEINAMKTLLARNGIAIPSGVSSPPRDQDSVVEERWGGDANTAEREVTGGGMFEFSVTEKTTKQSHERIVVRRQPRKRSNERSTTALASDHSSPPFPATFNTPLSSSSSPFALVSSQDPTAIGMDFILSLEAPCLGHIPHTDANDNASPSGHALMASATLLHFHDPHTPSSTHSHNQSQSPAWTVPESGVQRLLELARSIPLDGEVTPVQAWACIRQHPQYERLRLERLEEMKSALLVWVKCYGFGGVVPLDVFEDIIRGGFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CQ27</accession>
    <name>A0A177CQ27_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Probable lysosomal cobalamin transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CC84DRAFT_1115891</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Probable lysosomal cobalamin transporter. Required to export cobalamin from lysosomes allowing its conversion to cofactors.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Lysosome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the LIMR family. LMBRD1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG09000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039365.1">
        <property type="nucleotide sequence ID" value="XM_018175440.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CQ27"/>
    <dbReference type="STRING" id="1460663.A0A177CQ27"/>
    <dbReference type="GeneID" id="28758926"/>
    <dbReference type="InParanoid" id="A0A177CQ27"/>
    <dbReference type="OrthoDB" id="73273at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072665">
        <property type="term" value="P:protein localization to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050854">
        <property type="entry name" value="LMBD1_LysCbl_Transport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006876">
        <property type="entry name" value="LMBR1-like_membr_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16130:SF2">
        <property type="entry name" value="LYSOSOMAL COBALAMIN TRANSPORT ESCORT PROTEIN LMBD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16130">
        <property type="entry name" value="LYSOSOMAL COBALAMIN TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04791">
        <property type="entry name" value="LMBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0846">Cobalamin</keyword>
    <keyword evidence="10" id="KW-0170">Cobalt</keyword>
    <keyword evidence="9" id="KW-0458">Lysosome</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="7"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="38"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="95"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="139"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="191"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="315"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="379"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="419"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="509"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="240"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="244"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00025515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OAG09000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="589" mass="65805" checksum="DCD596CB8FF046A2" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CQR3</accession>
    <name>A0A177CQR3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_432701</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG09240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039605.1">
        <property type="nucleotide sequence ID" value="XM_018186230.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CQR3"/>
    <dbReference type="GeneID" id="28769716"/>
    <dbReference type="InParanoid" id="A0A177CQR3"/>
    <dbReference type="OrthoDB" id="6077919at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG09240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="110" mass="12563" checksum="49454BCA58FA009E" modified="2016-09-07" version="1">MSTHQDDVAAAQSSPADRSVVERMVRRSSRISERKKPASLKTASSDRSVLRTKTGRVGKAGKEPKFHFCDCGRSYTTINSLRRHQNRYCVLSHDELFRSPNPLQKHHEQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CQV5</accession>
    <name>A0A177CQV5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1215591</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG09159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039524.1">
        <property type="nucleotide sequence ID" value="XM_018182731.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CQV5"/>
    <dbReference type="GeneID" id="28766217"/>
    <dbReference type="InParanoid" id="A0A177CQV5"/>
    <dbReference type="OrthoDB" id="5400409at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="296"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG09159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="462" mass="52695" checksum="BD3553CC948E6FDC" modified="2016-09-07" version="1">MSFGFSFADIIKAGQIAKDIKEIWFTRLNRADILYSQFGRDVAGLEGLLETLGKAFAEYARVREIQLSIVDYHSWELKTLKEKHEQAEIVGGFLETVHECQDLLEENGKYLTKKANAWDNAKWHLFGGIERADKLRGRIQLHCTKISVFMQTLSVSVQAATASAIKDIQLQIERLPLLVLREILASLSGGPRKDRLHPVMPALHDQYIVALEMSKPDTYVDPTRFPLREGLDALAVSLEQSTIKFKGNGLGIWHPTVQQLNNLIKARWIFDRMVESATLREAGPESLWRWCLESMQEQIKVEYAKYEQEIVAEEANIASLDLESFRIWIPQEETGAISVTEADESQSEEKIFEVSLSDHGQQQKELIVFRRPRNELRLVTVTSRLNGGNTHTPNEDSKVVNMHQVQVIPRYALPGRPRVPYDKIIELCFPGASSGYTYQFKVDDDLHKFQQALLGYKVVLDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CRF8</accession>
    <name>A0A177CRF8_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CENP-V/GFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CC84DRAFT_1160924</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfa family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG09876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040241.1">
        <property type="nucleotide sequence ID" value="XM_018177617.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CRF8"/>
    <dbReference type="STRING" id="1460663.A0A177CRF8"/>
    <dbReference type="GeneID" id="28761103"/>
    <dbReference type="InParanoid" id="A0A177CRF8"/>
    <dbReference type="OrthoDB" id="6329284at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016846">
        <property type="term" value="F:carbon-sulfur lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1590.10">
        <property type="entry name" value="glutathione-dependent formaldehyde- activating enzyme (gfa)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006913">
        <property type="entry name" value="CENP-V/GFA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04828">
        <property type="entry name" value="GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CENP-V/GFA" evidence="4">
        <location>
            <begin position="2"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAG09876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="149" mass="16573" checksum="870BB366D1D63CEF" modified="2016-09-07" version="1">MCRKHSGSLLPQNISFPVAHLTPNLASFPTYKTYSSGPTTSRGFCSTCGSPLTFNDDKNRDLIEINIGSFDEEVLIGEKVEEDAWEDEYGRHVPRKGGWGYELGFPKYHIFAENEVKGVTDGFEGTKWLTDREGGTSFRGKVSGMKRGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2023-06-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CRX0</accession>
    <name>A0A177CRX0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_476201</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040638.1">
        <property type="nucleotide sequence ID" value="XM_018186419.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CRX0"/>
    <dbReference type="GeneID" id="28769905"/>
    <dbReference type="InParanoid" id="A0A177CRX0"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG10273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="131" mass="14420" checksum="2F53434001DECA8E" modified="2016-09-07" version="1">MYLPSAQHTSSCFIMPSTRIPTGLKMTCARNCLGAHAKQIDDNCHPNANTSWLIPQMPRCGWLDFISGGPIVSEMVSRMSHQGNHDLPGDKTSRSQDRLAPHLGPCQVRTTVEAAKDLCFESCSFHTPQPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CS50</accession>
    <name>A0A177CS50_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Dynactin subunit 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CC84DRAFT_1172144</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the dynactin subunits 5/6 family. Dynactin subunit 5 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG09589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039954.1">
        <property type="nucleotide sequence ID" value="XM_018179959.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CS50"/>
    <dbReference type="STRING" id="1460663.A0A177CS50"/>
    <dbReference type="GeneID" id="28763445"/>
    <dbReference type="InParanoid" id="A0A177CS50"/>
    <dbReference type="OrthoDB" id="417208at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005869">
        <property type="term" value="C:dynactin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03359">
        <property type="entry name" value="LbH_Dynactin_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047125">
        <property type="entry name" value="DCTN5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46126">
        <property type="entry name" value="DYNACTIN SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46126:SF1">
        <property type="entry name" value="DYNACTIN SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21711">
        <property type="entry name" value="DCTN5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00034706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAG09589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="238" mass="24322" checksum="E12F0A5FAA17F424" modified="2016-09-07" version="1">MSRPVAKKAAAKGEYIETLQLLFPSITLVATLPSSAPLTSYKDSGNKVSRRSAITGTANITLGGRTVIMADVVLRGDLHSTRPTASSSGKEGTPTSISIGKCTVVSTGTVLKPPCRMSRGAPNFYPMKIGDNVFIGPNCVISAIAISSHVHIGANVTIHPFAVIKENVKVLPNTVVPSAMVIAPGSVVGGRPARIVGEVGEGWGVSGGGAGGGLGVGGGGEEKWVEGGDLRELVRSIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CS70</accession>
    <name>A0A177CS70_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">aldehyde dehydrogenase (NAD(+))</fullName>
            <ecNumber evidence="4">1.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CC84DRAFT_1083367</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>an aldehyde + NAD(+) + H2O = a carboxylate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:16185"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.2.1.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.3" evidence="4"/>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG09730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040095.1">
        <property type="nucleotide sequence ID" value="XM_018174009.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CS70"/>
    <dbReference type="STRING" id="1460663.A0A177CS70"/>
    <dbReference type="GeneID" id="28757495"/>
    <dbReference type="InParanoid" id="A0A177CS70"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07102">
        <property type="entry name" value="ALDH_EDX86601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000009">
        <property type="entry name" value="Aldehyde dehydrogenase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000012">
        <property type="entry name" value="NAD-dependent succinate-semialdehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11699">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="8">
        <location>
            <begin position="4"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAG09730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="468" mass="51127" checksum="F420BDEA8036D24A" modified="2016-09-07" version="1">MSVETITTISPVTNKPILTRNGLSDADITSIPETAARAFEAYRRTTLSDRQAIVKKALKLLDERQDALGKELTEQMGRPISYTPKEITTAVARGEYMLKISEEALKATEGEAEKGFKRYIKKVPVGPVLILFPWNYPYLTLVNSLIPALLAGNSVILKPSPQTPTSAEQIKQIFADAGLPEGVLQIFHSGSITQIEAIARSPQIQLVCFTGSVANGLAIQTAASDRVPIRVGLELGGKDPAYVRSDVDIKWAAEEIVDGAVFNSGQSCCSVERVYVDEKIHDEFVSALQDVLKGYKLGDPMEKDTHVGPVVSSRSADSIRAHIKEALKKGAKDATPDNESFKSPPADGNYVAPTLLINVDHSMAVMTEETFGPVIPVMKVKNDAEAIKLMNDSQFGLTASIWTKDTNKGHELVEDVEAGTVFVNRCDYPAPDLAWVGWKDSGKGQTLSRFGFDQFVKLKSYHVKDYPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CSH4</accession>
    <name>A0A177CSH4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_456474</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG09918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040283.1">
        <property type="nucleotide sequence ID" value="XM_018186351.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CSH4"/>
    <dbReference type="STRING" id="1460663.A0A177CSH4"/>
    <dbReference type="GeneID" id="28769837"/>
    <dbReference type="InParanoid" id="A0A177CSH4"/>
    <dbReference type="OrthoDB" id="3883941at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG09918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="409" mass="44335" checksum="4F24A5B5BA254F0B" modified="2016-09-07" version="1">MLSKRVAAEAGALGRTALRPVPRTPVARIRVQNARFQSTSAGQNAPAGTSPALIGAVTGSLATLSIGYVWYRQSGAKDLLAATKTTKDYVSAGTKKLKEATPEPNEALDWLRDASKSYAVLIPGASGYIDTAFKDLDDIRSKHGDEVDNIVREAYSELQGVAKNGDISILTAKRAWDIIVKHLGRIGDLAGDSAQQIMDNHPQLKEKVGGNIDKLKEYGDKYGPEAKKEADRTWQQIQDVVKTGLSAENVTKIQKIVQEKVDKMKQLGDEAYKKGLEQAKPYLDKNPKVKELVESNADALKSGNVSELYNKIKKAVESGDMGDLESYVKSAASKAKESGFGGLDKYLGQIPGGDQIIPKLTQLQEAAEKHGDEAQKIIKDAVSEISEILKKKSSEAEKLAEKAKEDSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CSN1</accession>
    <name>A0A177CSN1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Chitin synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1213850</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040900.1">
        <property type="nucleotide sequence ID" value="XM_018182576.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CSN1"/>
    <dbReference type="STRING" id="1460663.A0A177CSN1"/>
    <dbReference type="GeneID" id="28766062"/>
    <dbReference type="InParanoid" id="A0A177CSN1"/>
    <dbReference type="OrthoDB" id="370884at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="155"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG10535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="336" mass="38889" checksum="05998D20550C86A0" modified="2016-09-07" version="1">MNTPRDAEKGSEPSDETDRHRERSPDQNQQYERGAFSNNLGRPQLFRDSTVENIVRDDGDEANRESDTDDNNISINDHTTYLESLSKFTWEDSFAKLEDTVRGCGYPDIPSLRDPARILSRSDLRKQRPLFWGIIAVLNIGMAMIEVFAHTGLVFFVFILFIKSKDFLSCLVSVFGLLIRRIYRVFRPLSPVSRQWILTLIPAYSESEEQIVKIIYLLRDNDVGKHRQVMVVLLDGRPRDIRSHMTRIIRDYKRTYISLKHKRGALKITAGFAEDVPVIVIEKMRNSGKKDSLVLCHDLFNVPRKNIPLYTRLLREEIWTKILPVLTEGEGFTTCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CSP2</accession>
    <name>A0A177CSP2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RNA-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_1160973</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG09952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040317.1">
        <property type="nucleotide sequence ID" value="XM_018177626.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CSP2"/>
    <dbReference type="FunCoup" id="A0A177CSP2">
        <property type="interactions" value="1174"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CSP2"/>
    <dbReference type="GeneID" id="28761112"/>
    <dbReference type="InParanoid" id="A0A177CSP2"/>
    <dbReference type="OrthoDB" id="267048at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12676">
        <property type="entry name" value="RRM3_Nop4p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12677">
        <property type="entry name" value="RRM4_Nop4p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000406">
        <property type="entry name" value="Related to Nucleolar protein NOP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034809">
        <property type="entry name" value="Nop4_RRM4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034808">
        <property type="entry name" value="Nop4p_RRM3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003954">
        <property type="entry name" value="RRM_euk-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051945">
        <property type="entry name" value="RRM_MRD1_RNA_proc_ribogen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48039">
        <property type="entry name" value="RNA-BINDING MOTIF PROTEIN 14B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48039:SF5">
        <property type="entry name" value="RNA-BINDING PROTEIN 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00361">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="42"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="152"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="318"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="502"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="239"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="659"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="30"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="246"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="256"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="720"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="738"/>
            <end position="752"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAG09952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="752" mass="83721" checksum="02D2610644E0AAA6" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CSY8</accession>
    <name>A0A177CSY8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HET-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1237568</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041008.1">
        <property type="nucleotide sequence ID" value="XM_018183904.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CSY8"/>
    <dbReference type="STRING" id="1460663.A0A177CSY8"/>
    <dbReference type="GeneID" id="28767390"/>
    <dbReference type="InParanoid" id="A0A177CSY8"/>
    <dbReference type="OrthoDB" id="5428863at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF1">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="2">
        <location>
            <begin position="231"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG10643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="742" mass="83613" checksum="34E9A5479DFA2E08" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CT54</accession>
    <name>A0A177CT54_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1213464</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040467.1">
        <property type="nucleotide sequence ID" value="XM_018182536.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CT54"/>
    <dbReference type="GeneID" id="28766022"/>
    <dbReference type="InParanoid" id="A0A177CT54"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG10102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="152" mass="16337" checksum="622E7DFFDDC3D39C" modified="2016-09-07" version="1">MEYGRASKLEDAKATSGPGRELVDKQTVVVEEYGAVDASTFPKLSISPGSPFPDDIKLMREHLHRHQALPRLQTQPIEPQGATFLNCAGSGSSVSPTSDSGWSVLTPTEAEAVMCQKTNDLPNEKDLVDDAAEGGNAVEKETTKEGTEYDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CTB7</accession>
    <name>A0A177CTB7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CC84DRAFT_1184694</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041138.1">
        <property type="nucleotide sequence ID" value="XM_018180769.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CTB7"/>
    <dbReference type="GeneID" id="28764255"/>
    <dbReference type="InParanoid" id="A0A177CTB7"/>
    <dbReference type="OrthoDB" id="4078873at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF50">
        <property type="entry name" value="MFS SIDEROCHROME IRON TRANSPORTER MIRB (AFU_ORTHOLOGUE AFUA_3G03640)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="34"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="154"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="196"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="239"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="265"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="357"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAG10773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="391" mass="42938" checksum="C1FFB1D018A1E6FB" modified="2016-09-07" version="1">MAKILDIWGRAEGFALMIALATLGLVLMACANTLAIFCAAQVFSSIGFAGVIYSIDVITSDAFHLRNRGSAFASPSSPYIVIAFAGLKASEGFYENIGCPRKEGRVMARETQRTTLQSIWHYDKEVDALGCFLFVCGLVVFLLPFSLADSAPNGWSTGCIIAMIVVGFLFLVLFGPWEALLAPHPFLTANLLFDRTVAGACLLSFNYQIVYSCWASYFSSFLQVVNIGFLIRKFGYFKWLLWVGVPLYVFAQGLMINFRRPDAHIGYLVIVMIICQQLAVLALLIVIGTIGGAVGNTISGAIWTNTFSQALTRYLPEDAQASVENIYGSLDVQLSYEWGSPTRTGIQQAYGYSQQKMLIAGTAIMSFSLVWVCMIRNINVKNIEQVKGVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CU34</accession>
    <name>A0A177CU34_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Altered inheritance of mitochondria protein 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_1161253</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AIM6 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040652.1">
        <property type="nucleotide sequence ID" value="XM_018177685.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CU34"/>
    <dbReference type="FunCoup" id="A0A177CU34">
        <property type="interactions" value="5"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CU34"/>
    <dbReference type="GeneID" id="28761171"/>
    <dbReference type="InParanoid" id="A0A177CU34"/>
    <dbReference type="OrthoDB" id="4153866at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051236">
        <property type="entry name" value="HAT_RTT109-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31571">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31571:SF1">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="72"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAG10287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="398" mass="45483" checksum="C679151C3476F46F" modified="2016-09-07" version="1">MSHMIELESLREEPISPTLDYGEDHGLLVSYSDARAYKTPACFRGIWEKLKHEAKQIFHPSAAVFPKRIANLLYATTLIFFGIFISTITIAFFRWKATDPFDTFFARFWDEGPSSAHNPAKYPIEFFGNVLPIPCHSHNDYWRRTPLFAALGSGCISVEADVFYRNNELYVGHTESALHPGRTLKSMYINRLVDLLDEMNPTHWRAADPKGVFYNAPHQSLTLVVDFKTAGNETWSALYEQLQPLRERGWLTNWNGTHRVERPLTVVASGAADFDLVASHNQVRDIFLDAPLAELDHPFDDGTRFRYNVSNSHLASANFHDAIGSVFRGKVNDEQVLLIRKHTQSAQQRGLVPRYWGTPRWPRGLRDEIWALLVRENIGLLNVDDLRGARKGNWGSWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CUL4</accession>
    <name>A0A177CUL4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1213912</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040967.1">
        <property type="nucleotide sequence ID" value="XM_018182588.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CUL4"/>
    <dbReference type="GeneID" id="28766074"/>
    <dbReference type="InParanoid" id="A0A177CUL4"/>
    <dbReference type="OrthoDB" id="3792489at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025649">
        <property type="entry name" value="DUF4360"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14273">
        <property type="entry name" value="DUF4360"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008058606" description="Secreted protein" evidence="1">
        <location>
            <begin position="17"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG10602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="196" mass="20381" checksum="738E3DA431D5714B" modified="2016-09-07" version="1">MYFKSLAAFLPAVAVALPTTTPIVHRVAKAIVARAPPEANVVLKSVTASGTGCSGNSASFVLGIGDGATVGFDNMIVDSTQIDKTKRCVITLDLQLDSKWKYTINKATNVRGYVENDGGTYKVAYTVGGKTSDVSNSIPSNPSGGNWVDTSTSPGITSAYGGGVANIDILLRLLPAGTQVATATIDSLDIQFEYSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CUQ5</accession>
    <name>A0A177CUQ5_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nascent polypeptide-associated complex subunit alpha-like UBA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1256317</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040854.1">
        <property type="nucleotide sequence ID" value="XM_018184612.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CUQ5"/>
    <dbReference type="STRING" id="1460663.A0A177CUQ5"/>
    <dbReference type="GeneID" id="28768098"/>
    <dbReference type="InParanoid" id="A0A177CUQ5"/>
    <dbReference type="OrthoDB" id="285219at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043066">
        <property type="term" value="P:negative regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050821">
        <property type="term" value="P:protein stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14361">
        <property type="entry name" value="UBA_HYPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052617">
        <property type="entry name" value="Huntingtin-int_K"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038922">
        <property type="entry name" value="HYPK_UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044034">
        <property type="entry name" value="NAC-like_UBA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31184:SF2">
        <property type="entry name" value="HUNTINGTIN-INTERACTING PROTEIN K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31184">
        <property type="entry name" value="HUNTINGTIN-INTERACTING PROTEIN K FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19026">
        <property type="entry name" value="UBA_HYPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nascent polypeptide-associated complex subunit alpha-like UBA" evidence="2">
        <location>
            <begin position="75"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG10489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="120" mass="12501" checksum="A17E03E579DFB161" modified="2016-09-07" version="1">MAEPQPSNIQEGASEAPPPTTGSAEDRKAAAALSALDEQGDDEAGKKEVDSKAVEKAMKNLSVKDGKGDAQKKAVKIEASDVNLLVTELELPKPKATELLRANDGNVLKAISSFVTPAFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CVD0</accession>
    <name>A0A177CVD0_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 12">Dihydrolipoyl dehydrogenase</fullName>
            <ecNumber evidence="2 12">1.8.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CC84DRAFT_1159037</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] + NAD(+) = N(6)-[(R)-lipoyl]-L-lysyl-[protein] + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15045"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="EC" id="1.8.1.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10 12">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="10 12">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="12">The active site is a redox-active disulfide bond.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 12">Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.4" evidence="2 12"/>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG11515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041880.1">
        <property type="nucleotide sequence ID" value="XM_018177121.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CVD0"/>
    <dbReference type="FunCoup" id="A0A177CVD0">
        <property type="interactions" value="1073"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CVD0"/>
    <dbReference type="GeneID" id="28760607"/>
    <dbReference type="InParanoid" id="A0A177CVD0"/>
    <dbReference type="OrthoDB" id="361797at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005960">
        <property type="term" value="C:glycine cleavage complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042645">
        <property type="term" value="C:mitochondrial nucleoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045252">
        <property type="term" value="C:oxoglutarate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045254">
        <property type="term" value="C:pyruvate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004148">
        <property type="term" value="F:dihydrolipoyl dehydrogenase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004375">
        <property type="term" value="F:glycine dehydrogenase (decarboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004591">
        <property type="term" value="F:oxoglutarate dehydrogenase (succinyl-transferring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006103">
        <property type="term" value="P:2-oxoglutarate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045333">
        <property type="term" value="P:cellular respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006546">
        <property type="term" value="P:glycine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042743">
        <property type="term" value="P:hydrogen peroxide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006550">
        <property type="term" value="P:L-isoleucine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006552">
        <property type="term" value="P:L-leucine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006564">
        <property type="term" value="P:L-serine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006574">
        <property type="term" value="P:L-valine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.390.30:FF:000001">
        <property type="entry name" value="Dihydrolipoyl dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000025">
        <property type="entry name" value="Dihydrolipoyl dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050151">
        <property type="entry name" value="Class-I_Pyr_Nuc-Dis_Oxidored"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006258">
        <property type="entry name" value="Lipoamide_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001100">
        <property type="entry name" value="Pyr_nuc-diS_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012999">
        <property type="entry name" value="Pyr_OxRdtase_I_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01350">
        <property type="entry name" value="lipoamide_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22912:SF151">
        <property type="entry name" value="DIHYDROLIPOYL DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22912">
        <property type="entry name" value="DISULFIDE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000350">
        <property type="entry name" value="Mercury_reductase_MerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="FAD/NAD-linked reductases, dimerisation (C-terminal) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00076">
        <property type="entry name" value="PYRIDINE_REDOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 10 12" id="KW-0274">FAD</keyword>
    <keyword evidence="3 12" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6 10 12" id="KW-0520">NAD</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8 12" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="14">
        <location>
            <begin position="44"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="Pyridine nucleotide-disulphide oxidoreductase dimerisation" evidence="13">
        <location>
            <begin position="390"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="488"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="185"/>
            <end position="187"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="222"/>
            <end position="229"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="245"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="315"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="356"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="362"/>
            <end position="365"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="11">
        <location>
            <begin position="82"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OAG11515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="509" mass="54394" checksum="C80FCFA95F5A49F6" modified="2016-09-07" version="1">MFRAVASRAVPRAARPVTQSTFCAPNIYFQGRLRRGYASEAEEKDLVIIGGGVAGYVAAIKAGQSGLKVACIEKRGALGGTCLNVGCIPSKSLLNNSHLYHQILHDTKNRGIEVGDVKLNLAAMMKAKDTSVSGLTKGIEFLFKKNNVEYIKGTGAFKDEHTVAVNLIEGGGETTVRGKNILIATGSEATPFPGLTIDEKKVITSTGAIALQEVPKKMTVIGGGIIGLEMASVWSRLGSEVTVVEYLGQIGGPGMDKDVAKQAQKLLQKQGMKFKLNTKVVSGDADGEGVKVTVEAAKGGKEETLDADVCLVAIGRRPYTNGLGLENIGLEVDERGRLIIDQEYRTKIPHIRAIGDVTFGPMLAHKAEEESVAVIEYITKGYGHVNYGAIPSVMYTHPEVAWVGQNEQELTAANVKYNVGQFPFSANSRAKTNLDTEGFVKMISDAETDRILGIHIIGPNAGEMIAEGVLALEYGASSEDVARTSHAHPTLSEAFKEAAMATYDKAVHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CVD9</accession>
    <name>A0A177CVD9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Mo25-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1182439</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Mo25 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG11493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041858.1">
        <property type="nucleotide sequence ID" value="XM_018180634.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CVD9"/>
    <dbReference type="FunCoup" id="A0A177CVD9">
        <property type="interactions" value="370"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CVD9"/>
    <dbReference type="GeneID" id="28764120"/>
    <dbReference type="InParanoid" id="A0A177CVD9"/>
    <dbReference type="OrthoDB" id="609103at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043539">
        <property type="term" value="F:protein serine/threonine kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000257">
        <property type="entry name" value="Conidiophore development protein hymA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013878">
        <property type="entry name" value="Mo25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10182">
        <property type="entry name" value="CALCIUM-BINDING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10182:SF3">
        <property type="entry name" value="PROTEIN MO25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08569">
        <property type="entry name" value="Mo25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG11493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="601" mass="67710" checksum="D8EDF2A3A51D2E66" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CXU6</accession>
    <name>A0A177CXU6_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cupin 2 conserved barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1200879</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG11670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042035.1">
        <property type="nucleotide sequence ID" value="XM_018181691.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CXU6"/>
    <dbReference type="GeneID" id="28765177"/>
    <dbReference type="InParanoid" id="A0A177CXU6"/>
    <dbReference type="OrthoDB" id="504210at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG11670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="226" mass="25634" checksum="085381E2FF2055ED" modified="2016-09-07" version="1">MTLTDTTSHVSTDSVALSYNKADKQTNQDVTMFYPTAETNYRITRAIAPKGSKFQVGAHWHEDYDEYMRIVQGRAKIRLGSTWKVYTPDDGEIKIPRMVVHDICRADKDAKPGEEDDEDMILEEWSDPSDGAKEIFFRHIFSVTIDKDFFGWKLPLQQLLIMMSADGYIEILPGPAGWYVTHGLYAALKPVAKLLGLKPFHDEYTPSRLADVRKAMESGAKPKKDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CY82</accession>
    <name>A0A177CY82_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CC84DRAFT_53363</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG11787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042152.1">
        <property type="nucleotide sequence ID" value="XM_018186642.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CY82"/>
    <dbReference type="STRING" id="1460663.A0A177CY82"/>
    <dbReference type="GeneID" id="28770128"/>
    <dbReference type="InParanoid" id="A0A177CY82"/>
    <dbReference type="OrthoDB" id="3934656at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11060">
        <property type="entry name" value="CYP57A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000113">
        <property type="entry name" value="Cytochrome P450 monooxygenase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF85">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 4 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="4">
        <location>
            <position position="459"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAG11787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="514" mass="58838" checksum="67D825746A12CD3F" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CYQ5</accession>
    <name>A0A177CYQ5_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">Ubiquitin-like protein ATG12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CC84DRAFT_1159513</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Ubiquitin-like protein involved in cytoplasm to vacuole transport (Cvt), autophagy vesicles formation, mitophagy, and nucleophagy.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Forms a conjugate with ATG5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Preautophagosomal structure membrane</location>
            <topology evidence="6">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the ATG12 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042523.1">
        <property type="nucleotide sequence ID" value="XM_018177255.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CYQ5"/>
    <dbReference type="STRING" id="1460663.A0A177CYQ5"/>
    <dbReference type="GeneID" id="28760741"/>
    <dbReference type="InParanoid" id="A0A177CYQ5"/>
    <dbReference type="OrthoDB" id="10003551at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034274">
        <property type="term" value="C:Atg12-Atg5-Atg16 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000421">
        <property type="term" value="C:autophagosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019776">
        <property type="term" value="F:Atg8-family ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097352">
        <property type="term" value="P:autophagosome maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061723">
        <property type="term" value="P:glycophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01612">
        <property type="entry name" value="Ubl_ATG12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007242">
        <property type="entry name" value="Atg12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13385">
        <property type="entry name" value="AUTOPHAGY PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13385:SF0">
        <property type="entry name" value="UBIQUITIN-LIKE PROTEIN ATG12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04110">
        <property type="entry name" value="APG12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0072">Autophagy</keyword>
    <keyword evidence="3 6" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <keyword evidence="4 6" id="KW-0833">Ubl conjugation pathway</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAG12158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="116" mass="12979" checksum="3C0DC5AABA0889EA" modified="2016-09-07" version="1">MAASTMLTTLPVDAKEALATDGKVHVQKVRIHLVAIGSAPRMSTMVFMMTASNRFEVVVRQIRNKLKLKPHESVFCYIGNVFSPALDESVENLWRCFKQGQKEELYVGYALSQAFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CZC9</accession>
    <name>A0A177CZC9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FAM192A/Fyv6 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CC84DRAFT_1053809</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018043011.1">
        <property type="nucleotide sequence ID" value="XM_018173510.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CZC9"/>
    <dbReference type="STRING" id="1460663.A0A177CZC9"/>
    <dbReference type="GeneID" id="28756996"/>
    <dbReference type="InParanoid" id="A0A177CZC9"/>
    <dbReference type="OrthoDB" id="75807at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039845">
        <property type="entry name" value="FAM192A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019331">
        <property type="entry name" value="FAM192A/Fyv6_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13495">
        <property type="entry name" value="NEFA-INTERACTING NUCLEAR PROTEIN NIP30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13495:SF0">
        <property type="entry name" value="PSME3-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10187">
        <property type="entry name" value="FAM192A_Fyv6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAM192A/Fyv6 N-terminal" evidence="4">
        <location>
            <begin position="5"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="110"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="110"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="137"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAG12646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="166" mass="19083" checksum="5C147F8745599E9B" modified="2016-09-07" version="1" fragment="single">MSSGFVSGGTIDAPNERDDEWRAAQAELEAKRLEREDRDKQQDGKSLYEVLQANKAAKQDAFEEATRLKNQYRALDDDEAEFLESVLEASRKKEAEVRKDTMEQLDAFRRRREEEERKALEAEAPEGAKEDEAHAHWVAHGRKRKKGPELLKGVKLRKTNEASDDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CZI4</accession>
    <name>A0A177CZI4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="16">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">CC84DRAFT_66032</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits. Binds 90S pre-ribosomal particles and dissociates from pre-60S ribosomal particles after processing of 27SB pre-rRNA. Required for the normal formation of 18S rRNA through the processing of pre-rRNAs at sites A0, A1 and A2, and the normal formation of 25S and 5.8S rRNAs through the processing of pre-rRNAs at sites C1 and C2.</text>
    </comment>
    <comment type="function">
        <text evidence="16">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="13">Component of pre-60S ribosomal complexes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="16">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the DEAD box helicase family. DDX55/SPB4 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="16"/>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042444.1">
        <property type="nucleotide sequence ID" value="XM_018187057.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CZI4"/>
    <dbReference type="FunCoup" id="A0A177CZI4">
        <property type="interactions" value="1150"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CZI4"/>
    <dbReference type="GeneID" id="28770543"/>
    <dbReference type="InParanoid" id="A0A177CZI4"/>
    <dbReference type="OrthoDB" id="7396459at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902626">
        <property type="term" value="P:assembly of large subunit precursor of preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000470">
        <property type="term" value="P:maturation of LSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd17960">
        <property type="entry name" value="DEADc_DDX55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056330">
        <property type="entry name" value="CTT_SPB4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025313">
        <property type="entry name" value="SPB4-like_CTE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13959">
        <property type="entry name" value="CTE_SPB4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23681">
        <property type="entry name" value="CTT_SPB4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01178">
        <property type="entry name" value="DUF4217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 15 21" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="8 16" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="20">
        <location>
            <begin position="11"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="18">
        <location>
            <begin position="42"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="19">
        <location>
            <begin position="295"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="561"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="14">
        <location>
            <begin position="11"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="121"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00037566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00038002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="OAG12079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="630" mass="70675" checksum="D40589927FA1A43B" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CZX3</accession>
    <name>A0A177CZX3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">SIR2-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CC84DRAFT_1201499</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sirtuin family. Class I subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042892.1">
        <property type="nucleotide sequence ID" value="XM_018181724.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CZX3"/>
    <dbReference type="FunCoup" id="A0A177CZX3">
        <property type="interactions" value="261"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CZX3"/>
    <dbReference type="GeneID" id="28765210"/>
    <dbReference type="InParanoid" id="A0A177CZX3"/>
    <dbReference type="OrthoDB" id="420264at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099115">
        <property type="term" value="C:chromosome, subtelomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031934">
        <property type="term" value="C:mating-type region heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005721">
        <property type="term" value="C:pericentric heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033553">
        <property type="term" value="C:rDNA heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032041">
        <property type="term" value="F:histone H3K14 deacetylase activity, NAD-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141222">
        <property type="term" value="F:histone H3K4 deacetylase activity, NAD-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046969">
        <property type="term" value="F:histone H3K9 deacetylase activity, NAD-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046970">
        <property type="term" value="F:histone H4K16 deacetylase activity, NAD-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031508">
        <property type="term" value="P:pericentric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030466">
        <property type="term" value="P:silent mating-type cassette heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902794">
        <property type="term" value="P:siRNA-independent facultative heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031509">
        <property type="term" value="P:subtelomeric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1600.10">
        <property type="entry name" value="SIR2/SIRT2 'Small Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050134">
        <property type="entry name" value="NAD-dep_sirtuin_deacylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026591">
        <property type="entry name" value="Sirtuin_cat_small_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085:SF9">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACETYLASE SIRTUIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="9">
        <location>
            <begin position="163"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="337"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="11"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="337"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="291"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="299"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="302"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="323"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="326"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAG12527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="492" mass="55119" checksum="37A6D075B4E7D7D7" modified="2016-09-07" version="1">MAHTQPGPVMVQEAAQAQAQDPAPPVDEASGPALSAYSKPAAENGNSNGTGAPAPHARDEDDDESDVDAWDILLEQAEESEPIAAGQDECTIDEGRQIRQRLHKVGADQFVREYITSERYTARKLLSAFNVRLPHGFLDDEPDEAFYELLGRAIMRELTKRSRLPQYKTIDDAAKLLQERKNIIVITGAGISTSLGIPDFRSKNTGFYSELSQMGYDDPEDVFNIDNFDADPTVFYKLAGRIVPDLKKWSPTHQFIRLLQDKEKLLTNYTQNIDNVESQAGLRQEKLIQCHGSWAMATCRKCGYKVPGEDIFDAVRARTPAQCKHCIENIAALKAGKKRKRSSNGSKKRRGPGGFDDSDSDGAYDIPEPGIMKPDITFFGEQLPNNFFDRLREHDREKADLVIVIGTSMKVQPVCEIPNFLPRDVPQIYISRDPIHHINFDINLLGDCDVVVAELARRAGWDLKHTMIPQEQRVEVSIIDEVDHTYKVKQSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177D045</accession>
    <name>A0A177D045_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">IEC3 subunit of the Ino80 complex, chromatin re-modelling-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_1080344</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042845.1">
        <property type="nucleotide sequence ID" value="XM_018173890.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177D045"/>
    <dbReference type="STRING" id="1460663.A0A177D045"/>
    <dbReference type="GeneID" id="28757376"/>
    <dbReference type="InParanoid" id="A0A177D045"/>
    <dbReference type="OrthoDB" id="4095124at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031011">
        <property type="term" value="C:Ino80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055449">
        <property type="entry name" value="Iec3-like_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032742">
        <property type="entry name" value="Iec3_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24244">
        <property type="entry name" value="Iec3-like_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14612">
        <property type="entry name" value="Ino80_Iec3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="INO80 complex subunit 3 N-terminal" evidence="2">
        <location>
            <begin position="33"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="INO80 complex subunit 3-like middle region" evidence="3">
        <location>
            <begin position="155"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="211"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="247"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="250"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAG12480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="355" mass="39023" checksum="0942E07CC706A600" modified="2016-09-07" version="1">MASPGDAPADAPPQPAVHAAHEHDGAQSKPVKRSWRRKYRKMRVRFDETMTASNNYILEEWKSQAVARRLREQNDQILDILLEMNDSARLPARLRLDLREQAEIDAKPTIEDPEVVQQRLNSLRTELANGIITADEYTRRAEALHNSQTIQLSRSLAGLEAKIPHSTEAPDPPIEGLDLSETAPGYMSPTHEEEYLALLDQAFADPNAFDARPIRIPSSHPPPTEKDLSVRNPDSVYSWLRKHQPQVFLQDKDPQHPENMAEKAAPKANAGARGKRQSAAAGTPGPKTDHEEDEGLEGEPGAPGKGGRKSKGGENDSAYRPKGGSSRAPKRKREDGEPAAKGNKRKRQSAAGAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177D062</accession>
    <name>A0A177D062_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha-1,6-mannosyltransferase Och1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1077568</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 32 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018043103.1">
        <property type="nucleotide sequence ID" value="XM_018173761.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177D062"/>
    <dbReference type="STRING" id="1460663.A0A177D062"/>
    <dbReference type="GeneID" id="28757247"/>
    <dbReference type="InParanoid" id="A0A177D062"/>
    <dbReference type="OrthoDB" id="409543at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000136">
        <property type="term" value="C:mannan polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000009">
        <property type="term" value="F:alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.20:FF:000004">
        <property type="entry name" value="Glycosyltransferase family 32 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007577">
        <property type="entry name" value="GlycoTrfase_DXD_sugar-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039367">
        <property type="entry name" value="Och1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31834">
        <property type="entry name" value="INITIATION-SPECIFIC ALPHA-1,6-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31834:SF8">
        <property type="entry name" value="TRANSFERASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G14040)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04488">
        <property type="entry name" value="Gly_transf_sug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="23"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG12738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="388" mass="44509" checksum="EE34E27D917D7C72" modified="2016-09-07" version="1">MPVHSPIASHFRSRLTTQVRRVLPAYLALLFIVLFFANAHFFTAPIRAAHKYRRELKYQQPLQVSTTTIPKKIWQTWKQGPLTFEQRDSDTAKTWPAKNPNYRYEVLTDDNALEYVEEHYGVNGFNRPDIIDLYRELNITIIRADLLRYLIMYAEGGVYADIDVECLRPVQRFIPERYTELEVDMIIGVEIDEPAFADHPVLGSKCKSFCQWTFAAKPRLPVMMRLIENIQEWIHDLSKKKGVSVGQLELDFNEVISGTGPSAFTDAVLAQMTAMNGGKEVTWDPFHNLAESRLEHGILVLNVEAFAAGQGHSDSGNHDSRGALVKHHYHASGWPSLHPRRNHPMYGEVEKCNWKPECVAEWDKNVADWDKLSKEEQDKLLASKPPQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177D0A0</accession>
    <name>A0A177D0A0_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Kinase</fullName>
            <ecNumber evidence="4">2.7.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CC84DRAFT_1136460</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the inositol phosphokinase (IPK) family.</text>
    </comment>
    <dbReference type="EC" id="2.7.-.-" evidence="4"/>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG13124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018043489.1">
        <property type="nucleotide sequence ID" value="XM_018176100.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A177D0A0">
        <property type="interactions" value="192"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177D0A0"/>
    <dbReference type="GeneID" id="28759586"/>
    <dbReference type="InParanoid" id="A0A177D0A0"/>
    <dbReference type="OrthoDB" id="2573163at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000824">
        <property type="term" value="F:inositol-1,4,5,6-tetrakisphosphate 3-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008440">
        <property type="term" value="F:inositol-1,4,5-trisphosphate 3-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032958">
        <property type="term" value="P:inositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.160">
        <property type="entry name" value="Inositol polyphosphate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005522">
        <property type="entry name" value="IPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038286">
        <property type="entry name" value="IPK_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12400">
        <property type="entry name" value="INOSITOL POLYPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12400:SF21">
        <property type="entry name" value="KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03770">
        <property type="entry name" value="IPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56104">
        <property type="entry name" value="SAICAR synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="269"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="376"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="659"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="801"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="841"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1140"/>
            <end position="1181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1249"/>
            <end position="1269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="27"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="127"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="141"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="269"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="317"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="329"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="464"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="519"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="551"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="686"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="801"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="842"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1172"/>
            <end position="1181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1249"/>
            <end position="1259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAG13124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="1283" mass="142101" checksum="DDF4C9AF28377801" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177D1I7</accession>
    <name>A0A177D1I7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_179841</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG13097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018043462.1">
        <property type="nucleotide sequence ID" value="XM_018185479.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177D1I7"/>
    <dbReference type="GeneID" id="28768965"/>
    <dbReference type="InParanoid" id="A0A177D1I7"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG13097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="283" mass="31660" checksum="D81233F49E12B569" modified="2016-09-07" version="1">MASTLNPPHQQLARQHPRYKHARNLTAIPVPPQASPRSPPSSHAISTPRSKLRAFTSMANPPPEKTHARRNGKEVAAPARVGLLAVPQPGSENIRIDGSRARHLCCAEGIKRRRARRGVRRWQRHGVQHGWRLWKRGQQGRLRMCVAARRARVFRRARTCGLCGMRGVGLCLCEGTALASGVVSAGTAGGATACRECRAVRASRVRFQTGWQTVPFGGLDWLALQTQAVRARWHWAEMAWYGQFCMGVNFMYMRWYAVHERFATHSADCGLRESTPQVSTWSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BU57</accession>
    <name>A0A177BU57_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_410778</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441563">
        <property type="protein sequence ID" value="OAF98953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029319.1">
        <property type="nucleotide sequence ID" value="XM_018186099.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BU57"/>
    <dbReference type="GeneID" id="28769585"/>
    <dbReference type="InParanoid" id="A0A177BU57"/>
    <dbReference type="OrthoDB" id="10577581at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAF98953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="205" mass="22051" checksum="89D2BF1194E7D0C1" modified="2016-09-07" version="1">MSNVGVEEAVGKCGDKEIYKRTCDRCCCCCSMTADAARWSCTLHYGGLTGISGELEVRRVMQRAPVEGRTNEERAIGQPFRRMVMCCAECRRQRVQQESELAEGGSREQWSKSEGGRAGADTQQAVTAHGMEDVLSGSLLLREAGQQRLTGALPSSARFQGAGADSVLRAGYQESSHCAAWALAVLGGAPRARSSSNSNTTPKQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BUF7</accession>
    <name>A0A177BUF7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1049810</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441565">
        <property type="protein sequence ID" value="OAF98610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018028976.1">
        <property type="nucleotide sequence ID" value="XM_018173459.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BUF7"/>
    <dbReference type="STRING" id="1460663.A0A177BUF7"/>
    <dbReference type="GeneID" id="28756945"/>
    <dbReference type="InParanoid" id="A0A177BUF7"/>
    <dbReference type="OrthoDB" id="3943268at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAF98610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="170" mass="18980" checksum="E510152163146486" modified="2016-09-07" version="1" fragment="single">MKDARELFPWQGNQKILASEFWASLDGQDESCQMEALLRVLAAFIFHKHNGFVFTSGLIHFTAILGIDADAGRLRPAKHYSYLLAGVVYCVRVLGAEVLLPASQRDRQADNELAAFLTKRREFLADGSYSPISEILSLLAFSKHIAFNDGNAGAALWSQDKKILYYRGKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BVN7</accession>
    <name>A0A177BVN7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SRR1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1169979</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441565">
        <property type="protein sequence ID" value="OAF98607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018028973.1">
        <property type="nucleotide sequence ID" value="XM_018179803.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BVN7"/>
    <dbReference type="GeneID" id="28763289"/>
    <dbReference type="InParanoid" id="A0A177BVN7"/>
    <dbReference type="OrthoDB" id="5230585at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAF98607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="172" mass="20403" checksum="C55A08174FBAC125" modified="2016-09-07" version="1">MDLEYFTIRLIDGTEACIKNPMFIERCLIWRPHVTYREYWRLIYHCLYLSASYCLLWSRLKEVFSVRMVAKIICFGLGDMCRGPLEWYRRTIQHSVALTMADMCTKEMLKGKGFLIIRPFRAGGFTEIKDDSIIFSAFADLESPCMKKMWDEYKRYDFLVLPEDVELLKSVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BVQ3</accession>
    <name>A0A177BVQ3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">USP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_401799</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441562">
        <property type="protein sequence ID" value="OAF99404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029770.1">
        <property type="nucleotide sequence ID" value="XM_018186045.1"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177BVQ3"/>
    <dbReference type="GeneID" id="28769531"/>
    <dbReference type="InParanoid" id="A0A177BVQ3"/>
    <dbReference type="OrthoDB" id="420187at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000022">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021905">
        <property type="entry name" value="DUF3517"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF925">
        <property type="entry name" value="UBIQUITINYL HYDROLASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12030">
        <property type="entry name" value="DUF3517"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="USP" evidence="2">
        <location>
            <begin position="1564"/>
            <end position="1888"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2461"/>
            <end position="2499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="90"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="114"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2464"/>
            <end position="2474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="2486"/>
            <end position="2499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAF99404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="2499" mass="282591" checksum="8D24735463418250" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BVY3</accession>
    <name>A0A177BVY3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Protein translation factor SUI1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CC84DRAFT_1169106</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Additional factor that functions in concert with eIF-2 and the initiator tRNA in directing the ribosome to the proper start site of translation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the SUI1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441561">
        <property type="protein sequence ID" value="OAF99572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029938.1">
        <property type="nucleotide sequence ID" value="XM_018179572.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BVY3"/>
    <dbReference type="FunCoup" id="A0A177BVY3">
        <property type="interactions" value="766"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177BVY3"/>
    <dbReference type="GeneID" id="28763058"/>
    <dbReference type="InParanoid" id="A0A177BVY3"/>
    <dbReference type="OrthoDB" id="10248435at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11566">
        <property type="entry name" value="eIF1_SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.780.10:FF:000005">
        <property type="entry name" value="Sui1 translation initiation factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.780.10">
        <property type="entry name" value="SUI1-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001950">
        <property type="entry name" value="SUI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036877">
        <property type="entry name" value="SUI1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005874">
        <property type="entry name" value="SUI1_euk"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01160">
        <property type="entry name" value="SUI1_MOF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10388">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01253">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004499">
        <property type="entry name" value="SUI1_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55159">
        <property type="entry name" value="eIF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50296">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="SUI1" evidence="5">
        <location>
            <begin position="32"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00060093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAF99572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="117" mass="13198" checksum="C379056A543AA82B" modified="2016-09-07" version="1">MTTDIQNLKSFDPFAEAEDSVGDVKTTSQNYIHIRIQQRNGRKTLTTVQGLPKKFDQKKILKVIKKKFACNGTVVTDSEMGEVIQLQGDQRKDVQEFLTDKKEGLGLDAKTIKVHGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BWI6</accession>
    <name>A0A177BWI6_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CC84DRAFT_1156871</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441561">
        <property type="protein sequence ID" value="OAF99772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030138.1">
        <property type="nucleotide sequence ID" value="XM_018176987.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BWI6"/>
    <dbReference type="GeneID" id="28760473"/>
    <dbReference type="InParanoid" id="A0A177BWI6"/>
    <dbReference type="OrthoDB" id="61113at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF47">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="110"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="146"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="201"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="233"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="272"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="53"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="326"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAF99772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="388" mass="43733" checksum="F2CDA887F43B9946" modified="2016-09-07" version="1">MGESAMNEFMPIILEMMKNPPDANESIPVVNHFSTAIAVTMPFLVLSVVAVGLRLYTRLHLVREPGWDDVFVAIAVILNLVGQTTFLGGVKAGIGQHLIYILGRLPNAMKWFYVANAAYTSTTVCIKLSLILQYLRLFREGYRRTITLIVLAVVVLWGGTFSFMAWFPCFPVSGFWNKTKAPPATCYAFGYRTTHEARNTLFAFAGSNMSLDILVFLIPLTEYFQPNLKRKQVLAMTGLFGVGLIVILMAVLRLWSGLKYNNRGIIMYDYTFWLPEVLVFSCLEIDFAIICASMPIFWPSVVAAWNQIYVTKEVIVTVEHRDDDNKGDLEMARTSSRRSNESTEGLVTENSTEGRSFFIEDLPTLRIVQIQPLEETVRMSWGGTALKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BWW7</accession>
    <name>A0A177BWW7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Bacteriocin-protection protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_374366</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441561">
        <property type="protein sequence ID" value="OAF99635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030001.1">
        <property type="nucleotide sequence ID" value="XM_018185961.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BWW7"/>
    <dbReference type="STRING" id="1460663.A0A177BWW7"/>
    <dbReference type="GeneID" id="28769447"/>
    <dbReference type="InParanoid" id="A0A177BWW7"/>
    <dbReference type="OrthoDB" id="10263401at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13376">
        <property type="entry name" value="OmdA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="209"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAF99635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="241" mass="26998" checksum="C59114EDE50D8E54" modified="2016-09-07" version="1">MPKELPILRLADAAAWRNWLAREGSLSEGVMLATIKKGAQDADTNLRYDQALDEALCYGWIDSGGRKVDDSIYLFRFCPRKPGSLWSKRNVSYVERLEKENRMQPAGRATIEAAKANGRWASAYSGSGNTEMPPDFLAALEKAPAAKATWEQLNKGNRWRIYFRLNNLKTAAGREKRIQADVEDLARGKPPTPQKRTPAREKSTKKGDSSSSPALDSSSESTQQKSRRQTRTGRFIPSYTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BWX9</accession>
    <name>A0A177BWX9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Exosome complex exonuclease-like protein Rrp6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CC84DRAFT_1264025</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the exosome component 10/RRP6 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441561">
        <property type="protein sequence ID" value="OAF99645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030011.1">
        <property type="nucleotide sequence ID" value="XM_018185275.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BWX9"/>
    <dbReference type="FunCoup" id="A0A177BWX9">
        <property type="interactions" value="947"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177BWX9"/>
    <dbReference type="GeneID" id="28768761"/>
    <dbReference type="InParanoid" id="A0A177BWX9"/>
    <dbReference type="OrthoDB" id="2250022at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071920">
        <property type="term" value="C:cleavage body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990342">
        <property type="term" value="C:heterochromatin island"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990251">
        <property type="term" value="C:nuclear exosome focus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140602">
        <property type="term" value="C:nucleolar peripheral inclusion body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003727">
        <property type="term" value="F:single-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000467">
        <property type="term" value="P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071044">
        <property type="term" value="P:histone mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033621">
        <property type="term" value="P:nuclear mRNA surveillance of meiosis-specific transcripts"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071040">
        <property type="term" value="P:nuclear polyadenylation-dependent antisense transcript catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071039">
        <property type="term" value="P:nuclear polyadenylation-dependent CUT catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071036">
        <property type="term" value="P:nuclear polyadenylation-dependent snoRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071037">
        <property type="term" value="P:nuclear polyadenylation-dependent snRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071051">
        <property type="term" value="P:poly(A)-dependent snoRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140746">
        <property type="term" value="P:siRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06147">
        <property type="entry name" value="Rrp6p_like_exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000059">
        <property type="entry name" value="Exosome complex exonuclease Rrp6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.80:FF:000001">
        <property type="entry name" value="Putative exosome component 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.80">
        <property type="entry name" value="HRDC domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002562">
        <property type="entry name" value="3'-5'_exonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012588">
        <property type="entry name" value="Exosome-assoc_fac_Rrp6_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010997">
        <property type="entry name" value="HRDC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002121">
        <property type="entry name" value="HRDC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044876">
        <property type="entry name" value="HRDC_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045092">
        <property type="entry name" value="Rrp6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049559">
        <property type="entry name" value="Rrp6p-like_exo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12124:SF47">
        <property type="entry name" value="EXOSOME COMPONENT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12124">
        <property type="entry name" value="POLYMYOSITIS/SCLERODERMA AUTOANTIGEN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01612">
        <property type="entry name" value="DNA_pol_A_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00570">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08066">
        <property type="entry name" value="PMC2NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00474">
        <property type="entry name" value="35EXOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00341">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47819">
        <property type="entry name" value="HRDC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50967">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="5" id="KW-0271">Exosome</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="HRDC" evidence="10">
        <location>
            <begin position="449"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="671"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="688"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="701"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="712"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="757"/>
            <end position="768"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00043957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OAF99645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="800" mass="89147" checksum="A64D36BB5AD8525B" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BWY3</accession>
    <name>A0A177BWY3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Extracellular membrane protein CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_1169950</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441564">
        <property type="protein sequence ID" value="OAF98829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029195.1">
        <property type="nucleotide sequence ID" value="XM_018179800.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BWY3"/>
    <dbReference type="STRING" id="1460663.A0A177BWY3"/>
    <dbReference type="GeneID" id="28763286"/>
    <dbReference type="InParanoid" id="A0A177BWY3"/>
    <dbReference type="OrthoDB" id="3783580at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008057413" description="Extracellular membrane protein CFEM domain-containing protein" evidence="3">
        <location>
            <begin position="20"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="194"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="168"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAF98829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="238" mass="24742" checksum="57FE817651C8EDC7" modified="2016-09-07" version="1">MLSLNLAVILFAAALAAQANDPATLGASIKFEKGYSLLPACINQCVWDIGDNDTPDIGGDVAIHLSCSAPWINGCYCRPQSATVAHAFISSCATYLCSTPQQSDVDAGTQVYDSYCSQALGAAYTPEGVEQAPATLTAASEVISTGTVATSRPTSTIAKQTSTNAAASQPSPIESSSSQEKPSDDKIAGLSKGAFIGVVVSASCSVLGLVFGIWFKFHKHREQMKLAQQNPGVIFGQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BXD0</accession>
    <name>A0A177BXD0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_415283</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glyoxalase I family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441563">
        <property type="protein sequence ID" value="OAF99046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029412.1">
        <property type="nucleotide sequence ID" value="XM_018186121.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BXD0"/>
    <dbReference type="STRING" id="1460663.A0A177BXD0"/>
    <dbReference type="GeneID" id="28769607"/>
    <dbReference type="InParanoid" id="A0A177BXD0"/>
    <dbReference type="OrthoDB" id="5371818at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07253">
        <property type="entry name" value="GLOD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="entry name" value="2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050383">
        <property type="entry name" value="GlyoxalaseI/FosfomycinResist"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21366:SF14">
        <property type="entry name" value="GLYOXALASE DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21366">
        <property type="entry name" value="GLYOXALASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="2">
        <location>
            <begin position="10"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAF99046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="141" mass="15557" checksum="0BCDAC65EA906898" modified="2016-09-07" version="1">MSKPLALVRSLDHLVLTCRNVPATCQWYSQHLGMTVERFTSASSPGTERVALRFGTQKINLHQQGKEFEPKATTALPGTADLCFLLAEEMDLEAALKDFKGEGIEVLEGGEVVDRTGARGKIRSFYVRDPDGNLIELSKYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2023-06-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BXH3</accession>
    <name>A0A177BXH3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_363594</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441560">
        <property type="protein sequence ID" value="OAG00214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030579.1">
        <property type="nucleotide sequence ID" value="XM_018185925.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BXH3"/>
    <dbReference type="GeneID" id="28769411"/>
    <dbReference type="InParanoid" id="A0A177BXH3"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008057424" evidence="1">
        <location>
            <begin position="21"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG00214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="150" mass="17286" checksum="1087B644A43D19F5" modified="2016-09-07" version="1">MFYNSTLAWLLASKDLLCEALEQCSLHASLIYNRRSHDMNPRSQRLALDKAKSRRLEIRCFGCHQGRTRTAKQPCKASLKRARKGAPVSRAWGAREWSHTLIFNASKPLSTLDACLTALRAWRSRRGPWRCHRRRSRGELSSYSCVLVEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BY83</accession>
    <name>A0A177BY83_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1221982</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441559">
        <property type="protein sequence ID" value="OAG00474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030839.1">
        <property type="nucleotide sequence ID" value="XM_018183318.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BY83"/>
    <dbReference type="STRING" id="1460663.A0A177BY83"/>
    <dbReference type="GeneID" id="28766804"/>
    <dbReference type="InParanoid" id="A0A177BY83"/>
    <dbReference type="OrthoDB" id="5394557at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="330"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG00474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="367" mass="39902" checksum="E9F12FB0A6E7191F" modified="2016-09-07" version="1">MIDLHNFNQIADTHQTMMQLYNPPSSPVRSRPLTYPSGIDNKSIMPQAWYSSPFNSEETSPVENYGLDQSSAYLPTQQAYNGGYDWSTDAKPATNSYLGPDSTTYRGLPYAQHNIRNVASSDALSHSMTSLQLTLPERPHTRSGLPVSQRPHLPIPQPSPAQTTRNVVDQLQDRRLRSVQAMGGSSLSNGGFVKPPLPFSSDTDVHGTTTVEVLSTQITSSAPASTTDTLSCFANTTTSTEAIPVTPAPQFDFSTSPLFDAMPAPAQPAYSNFRDSQDYKALTTSPTKDMISMARQLSRNNLYSVASASSSKNASGASDSMLVSGHRYTPLSQTQNHPQHQESSKSASNNTAFPVHRSVPATFNRTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BYH0</accession>
    <name>A0A177BYH0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Sporulation protein-like protein RMD1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CC84DRAFT_1169492</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RMD1/sif2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441562">
        <property type="protein sequence ID" value="OAF99379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029745.1">
        <property type="nucleotide sequence ID" value="XM_018179671.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BYH0"/>
    <dbReference type="FunCoup" id="A0A177BYH0">
        <property type="interactions" value="98"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177BYH0"/>
    <dbReference type="GeneID" id="28763157"/>
    <dbReference type="InParanoid" id="A0A177BYH0"/>
    <dbReference type="OrthoDB" id="18302at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003734">
        <property type="entry name" value="DUF155"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051624">
        <property type="entry name" value="RMD1/Sad1-interacting"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16255">
        <property type="entry name" value="REQUIRED FOR MEIOTIC NUCLEAR DIVISION PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16255:SF15">
        <property type="entry name" value="SPORULATION PROTEIN RMD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02582">
        <property type="entry name" value="DUF155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="489"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="domain" description="DUF155" evidence="4">
        <location>
            <begin position="293"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="204"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="39"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="117"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAF99379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="518" mass="58058" checksum="B799A5D3842439D0" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BYL1</accession>
    <name>A0A177BYL1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tyrosinase</fullName>
            <ecNumber evidence="3">1.14.18.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CC84DRAFT_371275</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>2 L-dopa + O2 = 2 L-dopaquinone + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:34287"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57504"/>
            <dbReference type="ChEBI" id="CHEBI:57924"/>
            <dbReference type="EC" id="1.14.18.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-tyrosine + O2 = L-dopaquinone + H2O</text>
            <dbReference type="Rhea" id="RHEA:18117"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57924"/>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
            <dbReference type="EC" id="1.14.18.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the tyrosinase family.</text>
    </comment>
    <dbReference type="EC" id="1.14.18.1" evidence="3"/>
    <dbReference type="EMBL" id="KV441561">
        <property type="protein sequence ID" value="OAF99617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029983.1">
        <property type="nucleotide sequence ID" value="XM_018185946.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BYL1"/>
    <dbReference type="STRING" id="1460663.A0A177BYL1"/>
    <dbReference type="GeneID" id="28769432"/>
    <dbReference type="InParanoid" id="A0A177BYL1"/>
    <dbReference type="OrthoDB" id="6132182at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004503">
        <property type="term" value="F:tyrosinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042438">
        <property type="term" value="P:melanin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.310.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1280.10">
        <property type="entry name" value="Di-copper center containing domain from catechol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008922">
        <property type="entry name" value="Di-copper_centre_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050316">
        <property type="entry name" value="Tyrosinase/Hemocyanin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041640">
        <property type="entry name" value="Tyrosinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002227">
        <property type="entry name" value="Tyrosinase_Cu-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474:SF76">
        <property type="entry name" value="SHKT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474">
        <property type="entry name" value="TYROSINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00264">
        <property type="entry name" value="Tyrosinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18132">
        <property type="entry name" value="Tyrosinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00092">
        <property type="entry name" value="TYROSINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48056">
        <property type="entry name" value="Di-copper centre-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00498">
        <property type="entry name" value="TYROSINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0186">Copper</keyword>
    <keyword evidence="8" id="KW-0470">Melanin biosynthesis</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008057467" description="tyrosinase" evidence="12">
        <location>
            <begin position="27"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosinase copper-binding" evidence="13">
        <location>
            <begin position="336"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="642"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="648"/>
            <end position="661"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS00498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OAF99617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="692" mass="76078" checksum="8B58D71689D1875F" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BYL4</accession>
    <name>A0A177BYL4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CC84DRAFT_1191386</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441562">
        <property type="protein sequence ID" value="OAF99516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029882.1">
        <property type="nucleotide sequence ID" value="XM_018181179.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BYL4"/>
    <dbReference type="STRING" id="1460663.A0A177BYL4"/>
    <dbReference type="GeneID" id="28764665"/>
    <dbReference type="InParanoid" id="A0A177BYL4"/>
    <dbReference type="OrthoDB" id="5290825at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015798">
        <property type="term" value="P:myo-inositol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015791">
        <property type="term" value="P:polyol transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000100">
        <property type="entry name" value="MFS sugar transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050814">
        <property type="entry name" value="Myo-inositol_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020">
        <property type="entry name" value="PROTON MYO-INOSITOL COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020:SF14">
        <property type="entry name" value="SUGAR TRANSPORTER, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="204"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="267"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="297"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="394"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="425"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="456"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="484"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="523"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="554"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="118"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OAF99516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="643" mass="71535" checksum="23453F697E6DF98E" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BZR5</accession>
    <name>A0A177BZR5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1180895</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441560">
        <property type="protein sequence ID" value="OAG00082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030447.1">
        <property type="nucleotide sequence ID" value="XM_018180517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BZR5"/>
    <dbReference type="GeneID" id="28764003"/>
    <dbReference type="InParanoid" id="A0A177BZR5"/>
    <dbReference type="OrthoDB" id="10565510at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008057494" evidence="2">
        <location>
            <begin position="18"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG00082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="139" mass="15653" checksum="2685492429D0E822" modified="2016-09-07" version="1">MRLCIVTFAALMTAAYALNDAAPNVNANNLAARSEPPKASATLDHKKHKHPHDGLKHKHDSTHHSKPTGKPEHTWKPEHPWKHKHDSTHHSKPTSKPEHTWKPEHTWEPKSTGKPEWKGKGKKGKKGKGVEDKEHKDGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BZT8</accession>
    <name>A0A177BZT8_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1229726</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441558">
        <property type="protein sequence ID" value="OAG01054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031419.1">
        <property type="nucleotide sequence ID" value="XM_018183672.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BZT8"/>
    <dbReference type="STRING" id="1460663.A0A177BZT8"/>
    <dbReference type="GeneID" id="28767158"/>
    <dbReference type="InParanoid" id="A0A177BZT8"/>
    <dbReference type="OrthoDB" id="2316594at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="227"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="452"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG01054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="477" mass="52707" checksum="53DC7D08642A66D5" modified="2016-09-07" version="1">MVASESYKELARYQAVLADRQPITSSNGSKVFDTADEELRMAPLVWWEVKTHFEPGHRPNRGYGVLGHIPNGSNSSGFGEAAQMSTKRTPVLLNIDSPWSAFLCGSQGSGKSHSLSCMLENCLLSDHTIIPKIGFNPHQLAGLVFHYDRCQGSGVCEAAYLCTNVPTTVLTILIILRGMAIESQGLATFDYEVFKRKLNDVQFARGQDGPMRLRLDLLESFMEKDLDQQQPMAKQPTKRRKNPPHAPKTILAMTENDFLIGTPGTLTIIDLTDPVIDPDAACALFDICLSVFIQQTQCGKIVALDEAHNYMTESGNSAKTFTEKLLRTVREQRHQAVRVVVATQEPSINPQLLDLCSITMVHRSTSPAWFKVLKQHIAAIYLNSLSSPMTADEDDKTAEIPQDDKALFNEIVKLKLGESLLFCPTAAFSVLGRGIRRMEGIYVKFKTRQRVTADGGKSKLAAETSKADSESGQVEEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C025</accession>
    <name>A0A177C025_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">HMG box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CC84DRAFT_1222088</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441559">
        <property type="protein sequence ID" value="OAG00591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030956.1">
        <property type="nucleotide sequence ID" value="XM_018183329.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C025"/>
    <dbReference type="STRING" id="1460663.A0A177C025"/>
    <dbReference type="GeneID" id="28766815"/>
    <dbReference type="InParanoid" id="A0A177C025"/>
    <dbReference type="OrthoDB" id="1919336at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09487">
        <property type="entry name" value="SAM_superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051965">
        <property type="entry name" value="ChromReg_NeuronalGeneExpr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46040">
        <property type="entry name" value="HIGH MOBILITY GROUP PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46040:SF3">
        <property type="entry name" value="HIGH MOBILITY GROUP PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00536">
        <property type="entry name" value="SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAM" evidence="5">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="HMG box" evidence="6">
        <location>
            <begin position="122"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="3">
        <location>
            <begin position="122"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="104"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="207"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="207"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="244"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="265"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="301"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="331"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="344"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="367"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="417"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAG00591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="485" mass="53128" checksum="25FE56F3BDDE6375" modified="2016-09-07" version="1">MSDLAERLSRLGLSQYLEAFVSEGFDSWETVLDITESDLGSLSVKLGHRRKLQRAIAESRGQSSGRPLPIALENAGSVDGSYRSDDSATETKIRQGEISVTGITPSAKRKYRRHPKPDEHAPERPPSAYVIFSNQVRETLKGQELSFTEIAKIVGERWQVLPADSRDACERQASSAKEKYYAELAEYKKTPEYESYQKYLEEFKAKHAAPPKEGKRSKLEADTPASTWTINHEHTERTIVRRISSAQSDQYAGQTRTEASPPIGPSRLPSGSSRPSKSTSPAIHNRSGFNSPRMPEHYSPLSASPRSATLNKESSFETTSSVMARDARGQSDASLPFSSSYGHAPSYPASTTPPSYSSHYQTPMDLPSRRSNREMHRLPPLTHEDTTLSSDSGQGGYAPSYTGQTLPPMDATKSMRVLPAPVPSAMASVPSPLDRPSVQSPPKPPLQHADYRTSSSLAALLRAGELARVADADADDEDMDTSGYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C0G0</accession>
    <name>A0A177C0G0_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1101134</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441558">
        <property type="protein sequence ID" value="OAG00965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031330.1">
        <property type="nucleotide sequence ID" value="XM_018174899.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C0G0"/>
    <dbReference type="STRING" id="1460663.A0A177C0G0"/>
    <dbReference type="GeneID" id="28758385"/>
    <dbReference type="InParanoid" id="A0A177C0G0"/>
    <dbReference type="OrthoDB" id="10017101at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransferase" evidence="1">
        <location>
            <begin position="90"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG00965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="244" mass="27489" checksum="2039C30909BA34C6" modified="2016-09-07" version="1">MSTSTTINPVLSESYSSSKLDEFPTVAIDKIEPSEDEDERTFHDTDAAYVLPNDNIEHQRLEVQHRLLWQLMGNKVFHAPVPKDTTRKTLDIGCGTGAVTYEMASTFPNAQVFGADLSAVPQVRQKLSNINYLLALKDVDLYCGANIPSLFAEAGLTDIRITRYMVPFSRWDGLTREEREMADYLETFVRDLIPVAIQKAGESAGPEYAGEVEDAIRDARKYHEAFDEGRNSLWMYVVCGRKPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C140</accession>
    <name>A0A177C140_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GA4 desaturase family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1222053</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the asaB hydroxylase/desaturase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441559">
        <property type="protein sequence ID" value="OAG00552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030917.1">
        <property type="nucleotide sequence ID" value="XM_018183327.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C140"/>
    <dbReference type="STRING" id="1460663.A0A177C140"/>
    <dbReference type="GeneID" id="28766813"/>
    <dbReference type="InParanoid" id="A0A177C140"/>
    <dbReference type="OrthoDB" id="412788at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044053">
        <property type="entry name" value="AsaB-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041278">
        <property type="entry name" value="CmcJ_NvfI_EfuI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34598">
        <property type="entry name" value="BLL6449 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34598:SF3">
        <property type="entry name" value="OXIDOREDUCTASE AN1597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG00552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="325" mass="37404" checksum="19645D5B96C3B332" modified="2016-09-07" version="1">MAPVATRDILPPREELPTEETTLYYYLELKDGGIIQTYPGTAFEKRRKHVPHDATIKDLRSIHDQFNVDNAGFEFVQHKSAVKDFSNEEEVEQVYYPECIDLIKKVSGADEVQVVSHMCRRDTHKASVDASQGLDDKTPVKVMNPARFVHVDQSYRGAEQILFLNLPEEEAERRLKKRWAIMNVWAPIMKPVKRDPLAFADFRSIDENDFRTVVANLPPPDAGEYGKVSRNMKHKPRAEYSSNGDVAPRYEVTNLAHNPNQQWYYASDMTPEEAWVFKIFDSKNDGRAKCAVHSSFPLKGQSDYGDPRTSIEVRCFVFWNDEKTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C198</accession>
    <name>A0A177C198_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Alpha-galactosidase</fullName>
            <ecNumber evidence="10">3.2.1.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Melibiase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CC84DRAFT_1127356</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Hydrolyzes a variety of simple alpha-D-galactoside as well as more complex molecules such as oligosaccharides and polysaccharides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>Hydrolysis of terminal, non-reducing alpha-D-galactose residues in alpha-D-galactosides, including galactose oligosaccharides, galactomannans and galactolipids.</text>
            <dbReference type="EC" id="3.2.1.22"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the glycosyl hydrolase 27 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.22" evidence="10"/>
    <dbReference type="EMBL" id="KV441557">
        <property type="protein sequence ID" value="OAG01564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031929.1">
        <property type="nucleotide sequence ID" value="XM_018175770.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C198"/>
    <dbReference type="STRING" id="1460663.A0A177C198"/>
    <dbReference type="GeneID" id="28759256"/>
    <dbReference type="InParanoid" id="A0A177C198"/>
    <dbReference type="OrthoDB" id="5795902at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004557">
        <property type="term" value="F:alpha-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14792">
        <property type="entry name" value="GH27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002241">
        <property type="entry name" value="Glyco_hydro_27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000111">
        <property type="entry name" value="Glyco_hydro_27/36_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041233">
        <property type="entry name" value="Melibiase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11452:SF61">
        <property type="entry name" value="ALPHA-GALACTOSIDASE B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11452">
        <property type="entry name" value="ALPHA-GALACTOSIDASE/ALPHA-N-ACETYLGALACTOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16499">
        <property type="entry name" value="Melibiase_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17801">
        <property type="entry name" value="Melibiase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00740">
        <property type="entry name" value="GLHYDRLASE27"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00512">
        <property type="entry name" value="ALPHA_GALACTOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008057655" description="Alpha-galactosidase" evidence="11">
        <location>
            <begin position="18"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha galactosidase C-terminal" evidence="12">
        <location>
            <begin position="355"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF17801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OAG01564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="441" mass="48710" checksum="693CA7903D0857E6" modified="2016-09-07" version="1">MLLRLLADLALITSGAALVLKDSVGKLPALGWNSWNAYHCDITEDQFLTAAHKFIELGLKDAGYEYVNIDDCWSDKDNRDESTSRLLPNLTRFPDGIKGTADKVHELGLKIGIYSSAGTQTCAGYPASIGYESIDAATWAEWGIDYLKYDNCNVPSNWTDSCKDCVPDSMHRDDLVNGTCTNTDGLCPPGYDFSTSNTAERFRIMRDALIAQNRTILYSLCEWGDAGVQTWGNTTGSSWRMSGDIDATWKSVLAYLNQNSFYLNYVDFWGHSDPDMLEVGNGLTIQEARTHFALWAAMKSPLLIGTDLATLDQDNVDVLKNKYLLAFNQDEVYGKPATPYKWGTNPDWTFNASFPAEYWSGASSNGTLVLLFNPFEDTRTKTASFAEVPRLEGGVKYRATDIWTGKDLGCVDGLQAAVEGHDTAGWLVGEECEASTFVSEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C1H3</accession>
    <name>A0A177C1H3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acyl-CoA N-acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_1167701</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441557">
        <property type="protein sequence ID" value="OAG01493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031858.1">
        <property type="nucleotide sequence ID" value="XM_018179239.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C1H3"/>
    <dbReference type="FunCoup" id="A0A177C1H3">
        <property type="interactions" value="24"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177C1H3"/>
    <dbReference type="GeneID" id="28762725"/>
    <dbReference type="InParanoid" id="A0A177C1H3"/>
    <dbReference type="OrthoDB" id="7305308at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051016">
        <property type="entry name" value="Diverse_Substrate_AcTransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10545:SF42">
        <property type="entry name" value="ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10545">
        <property type="entry name" value="DIAMINE N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="3">
        <location>
            <begin position="1"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAG01493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="150" mass="17434" checksum="DA70B873F76B3FBA" modified="2016-09-07" version="1">MSVSTLSKADWSQWQNLFRQYIAFYKTSIPEAQYENTFNRIIDPQGDLHAFAIREEDGTLNAIAHYLFHTTSWSDKPVCYLNDLFVNPDIRGKGYGRKLIVACGKAAQEKGCSKYYWLTQHENKVARKLYDTFGESGFAEYRIKLPSDKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C1U1</accession>
    <name>A0A177C1U1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">1-alkyl-2-acetylglycerophosphocholine esterase</fullName>
            <ecNumber evidence="1">3.1.1.47</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CC84DRAFT_1100886</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.1.47" evidence="1"/>
    <dbReference type="EMBL" id="KV441558">
        <property type="protein sequence ID" value="OAG00812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031177.1">
        <property type="nucleotide sequence ID" value="XM_018174888.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C1U1"/>
    <dbReference type="STRING" id="1460663.A0A177C1U1"/>
    <dbReference type="GeneID" id="28758374"/>
    <dbReference type="InParanoid" id="A0A177C1U1"/>
    <dbReference type="OrthoDB" id="2363873at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003847">
        <property type="term" value="F:1-alkyl-2-acetylglycerophosphocholine esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10272">
        <property type="entry name" value="PLATELET-ACTIVATING FACTOR ACETYLHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10272:SF0">
        <property type="entry name" value="PLATELET-ACTIVATING FACTOR ACETYLHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03403">
        <property type="entry name" value="PAF-AH_p_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="169"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="268"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="609"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="13"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="268"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="609"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="624"/>
            <end position="639"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAG00812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="683" mass="76314" checksum="BBF4412A215F9C59" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C1Y7</accession>
    <name>A0A177C1Y7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_1263188</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441558">
        <property type="protein sequence ID" value="OAG01171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031536.1">
        <property type="nucleotide sequence ID" value="XM_018185216.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C1Y7"/>
    <dbReference type="STRING" id="1460663.A0A177C1Y7"/>
    <dbReference type="GeneID" id="28768702"/>
    <dbReference type="InParanoid" id="A0A177C1Y7"/>
    <dbReference type="OrthoDB" id="16464at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050005">
        <property type="entry name" value="DenD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF043036">
        <property type="entry name" value="ErythonDh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43103:SF3">
        <property type="entry name" value="ADP-L-GLYCERO-D-MANNO-HEPTOSE-6-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43103">
        <property type="entry name" value="NUCLEOSIDE-DIPHOSPHATE-SUGAR EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="3">
        <location>
            <begin position="11"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAG01171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="328" mass="35015" checksum="020535CD94702244" modified="2016-09-07" version="1">MGSHPNSSEHILITGAGGFIGQELSNALLLSDPSIQLTLADVFEPPSPNASRTASVKADLTTQAAVDSLLSSQQWSTCYLLHGIMSGGAEANLDLGLAVNVDSHRLTLDYLRKQQPGVVVVFPSSLAVYGPPDSPDQQYDEKTIPIPQSSYGAEKLIVETLVNDYSRRGLIDGRVVRLPTVIVRPGAPSAAASSFASGIVREPLKGVQSTLPVSKDLAMWVCSPKTVVKNLVAMKDVPKEKFAKNRGRVVNLPGQTVTVRQILEALGEVGGEKALKLVEEKHDPKVEAIVASWPARFDISLAQGLGMKEDISLKEEVQSFAASLKSEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C233</accession>
    <name>A0A177C233_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">GCN5-related N-acetyltransferas-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CC84DRAFT_1229456</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the acetyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441558">
        <property type="protein sequence ID" value="OAG00912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031277.1">
        <property type="nucleotide sequence ID" value="XM_018183666.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C233"/>
    <dbReference type="STRING" id="1460663.A0A177C233"/>
    <dbReference type="GeneID" id="28767152"/>
    <dbReference type="InParanoid" id="A0A177C233"/>
    <dbReference type="OrthoDB" id="7305308at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000064">
        <property type="entry name" value="GNAT family acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051016">
        <property type="entry name" value="Diverse_Substrate_AcTransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10545">
        <property type="entry name" value="DIAMINE N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10545:SF29">
        <property type="entry name" value="GH14572P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="4">
        <location>
            <begin position="6"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAG00912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="172" mass="19201" checksum="A784BB491990FD05" modified="2016-09-07" version="1">MASNGATVRHATREDVNTIYDLIIELADYEKAKSSVKASPEILAKTLAFHDPSTPDTFTPGYARTFLLVAPEGEVAGMALYFYNYSTWTGVPGVYLEDLFVKTKYRKRGYGKALIKACAKECLRINGQRLEWSCLDWNTPSLEFYESLGATQKKEWVGLRAEGDALAKLAEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C2C8</accession>
    <name>A0A177C2C8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_269105</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441558">
        <property type="protein sequence ID" value="OAG00887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031252.1">
        <property type="nucleotide sequence ID" value="XM_018185679.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C2C8"/>
    <dbReference type="STRING" id="1460663.A0A177C2C8"/>
    <dbReference type="GeneID" id="28769165"/>
    <dbReference type="InParanoid" id="A0A177C2C8"/>
    <dbReference type="OrthoDB" id="3796964at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG00887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="140" mass="15857" checksum="30F96E17094E23FD" modified="2016-09-07" version="1">MHLARTLRDFGNYAVLDFVSTLVHKVIYVFLQAYACWWCRAWDRYHAAGGHGRLFQMLGKRMGGAVPRLLGVPVKLGRVESLLGDSGLREGKEGRLRGRVPSAHDFEVWRFEDADADADADVQGADVRRLIEKTLSEWEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C2F3</accession>
    <name>A0A177C2F3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_976432</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441556">
        <property type="protein sequence ID" value="OAG01974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032339.1">
        <property type="nucleotide sequence ID" value="XM_018188032.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C2F3"/>
    <dbReference type="STRING" id="1460663.A0A177C2F3"/>
    <dbReference type="GeneID" id="28771518"/>
    <dbReference type="InParanoid" id="A0A177C2F3"/>
    <dbReference type="OrthoDB" id="5422841at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="233"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="473"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="258"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="303"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="344"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="356"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="473"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG01974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="600" mass="65070" checksum="520FA8547404F23A" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2023-06-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C2N5</accession>
    <name>A0A177C2N5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_211786</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441557">
        <property type="protein sequence ID" value="OAG01705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032070.1">
        <property type="nucleotide sequence ID" value="XM_018185602.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C2N5"/>
    <dbReference type="GeneID" id="28769088"/>
    <dbReference type="InParanoid" id="A0A177C2N5"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG01705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="150" mass="16070" checksum="B4DC067242E491B2" modified="2016-09-07" version="1">MHQEETDCPLRAHLLSSFFTPSFSSPPSICSPIMHPRKSLVLLAFAILRCHTFSFSLASSSRDVAFGAHFSPTAATRSSKSAFGRWSTRDSDSCSARSDIEGGRGLGWAEEAFAGFKLGLMEGRGAREVLLVGAVVVEGVDLSGDMVERG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2023-06-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C4M3</accession>
    <name>A0A177C4M3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_898859</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG02583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032948.1">
        <property type="nucleotide sequence ID" value="XM_018187838.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C4M3"/>
    <dbReference type="GeneID" id="28771324"/>
    <dbReference type="InParanoid" id="A0A177C4M3"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG02583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="305" mass="33615" checksum="FED53C6BD3775CEA" modified="2016-09-07" version="1">MRYSRFGASQMSRTDDRSRVRGSRSSEAAVQRAIGCATMGGQSILRMPAYRMYRRRMADWQHHTRVLSSLQHGRLAPRVPFEVPVTPATACQRARVGPACRAAQARLASFPAPLLLPYSSGTLFRHTCTGTGRRARDTLQPCRFKLVKPLRGQFLSLTTPCVGDEQAGGGGCRCHASASAWHVSERQRASLPDARHHTTFGASAEMKNSATFPSKISPVNSGNSVAYEQHRQTTSQNLRPCLRAFSLFARASPAVLCIHRLIAIDVTALRMATVLSFVAPWQMCTSRYPPTSGWDITAPPLYTIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C4N6</accession>
    <name>A0A177C4N6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1053876</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441556">
        <property type="protein sequence ID" value="OAG02131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032496.1">
        <property type="nucleotide sequence ID" value="XM_018173514.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C4N6"/>
    <dbReference type="STRING" id="1460663.A0A177C4N6"/>
    <dbReference type="GeneID" id="28757000"/>
    <dbReference type="InParanoid" id="A0A177C4N6"/>
    <dbReference type="OrthoDB" id="420564at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35179:SF1">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35179">
        <property type="entry name" value="PROTEIN CBG02620"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="350"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG02131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="382" mass="43483" checksum="0AF3CB5133805B50" modified="2016-09-07" version="1" fragment="single">PNQPAEEQDEELVLDDDDEDDEEGAEEGKDDNDDDDEEKPKVITAKMRKKMDVMAKMVQKEAGQVILTLEKNDLTPTSMNVTWEQDNIKLLCSYNWQGANDGTNTIFVPGGPAKFVPKTTFPYVIEQDSGFQAADYNYVRKPWDPFAPLFTALGVMNPGHQFWDVDVLADRNNLRILLEFCQGKANGPLRLDVHMVYNTLVFVRKGEKFWRRQTNGIGNNFEKNFTQVGDDMEDATSHYRAIQYPMGPLNVVVRFEADAYFDDSASGDLDPTETDAVTGALLAERPRYDFRPPVRVLQKGHIVPTAQMAELKTVTHKEEGTSSVACQDQLWFGRTTHLFTGVYKIEDNKGKILRLKYENAKARVDKWEEKNQDALRMLVDLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2023-06-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C584</accession>
    <name>A0A177C584_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_909482</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG02675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033040.1">
        <property type="nucleotide sequence ID" value="XM_018187861.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C584"/>
    <dbReference type="GeneID" id="28771347"/>
    <dbReference type="InParanoid" id="A0A177C584"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG02675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="126" mass="14281" checksum="F0483706903FA45B" modified="2016-09-07" version="1">MYLALGRNPLCITTKKLTERSGMSMHTTIQSCGESSVITYTRSTSFTALILCCSRSLRAPHHGPRQSQWYRCRPIRVDVFELPKNLGRNTCRNTTSSGYRTVGYSCSHLDRSCAKTRGADHHRRIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C631</accession>
    <name>A0A177C631_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_935611</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG02866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033231.1">
        <property type="nucleotide sequence ID" value="XM_018187911.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C631"/>
    <dbReference type="STRING" id="1460663.A0A177C631"/>
    <dbReference type="GeneID" id="28771397"/>
    <dbReference type="InParanoid" id="A0A177C631"/>
    <dbReference type="OrthoDB" id="5427732at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008057863" evidence="2">
        <location>
            <begin position="21"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="132"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG02866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="322" mass="34912" checksum="A77976A20AD57724" modified="2016-09-07" version="1">MRSFRQLALYGLPLLGGVVANQGPASPSPTKSEVQNAVEAVYANANEAFQDLLNALPEESLHVALNSLNHFREGVFESNKRGVEHIHQDNPPLATKLIVAAVNDLKKRQAPTSNNGTAPTSQTEQPQSTEAPQSSDTPQSSQPPQESSQAPESSADQPQSTRAPGSSNAAPQSSAAPPESSAVVVPIAPDDVHPGQRTREQHRAADHDGRGRPAERGDELHVRRPRGTSHRRQLRGAQQHGEAESAEGCGGRIPRRGRCCARRRCACVVHMIRLWYTAIPSEGEKKEESKNTHNDITTLLMHAPYGRLYNVLHSSRHGTVLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C645</accession>
    <name>A0A177C645_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Tyrosine-protein phosphatase 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CC84DRAFT_1188774</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG02611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032976.1">
        <property type="nucleotide sequence ID" value="XM_018181008.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C645"/>
    <dbReference type="FunCoup" id="A0A177C645">
        <property type="interactions" value="882"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177C645"/>
    <dbReference type="GeneID" id="28764494"/>
    <dbReference type="InParanoid" id="A0A177C645"/>
    <dbReference type="OrthoDB" id="10253954at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18533">
        <property type="entry name" value="PTP_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050348">
        <property type="entry name" value="Protein-Tyr_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134">
        <property type="entry name" value="RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134:SF449">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="3">
        <location>
            <begin position="120"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="4">
        <location>
            <begin position="288"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="391"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="391"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAG02611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="441" mass="50175" checksum="9327B0B1AC6DF925" modified="2016-09-07" version="1">MASSQSLQVPPSPSSSKRSRSKDSTRSAATSLDTPYFTPSASAPSLVIPNLGETPQNLQPLEHDPAPYPAFLNLSADVHQKFVDLEWEQRQRVVQGLQHQNGDPEQQPSQWARCIGDDVRDRNRYLNVDPYQSNRVRLKVPDGTSDYINASPVELRSSSSDKVLKYIATQGPKSDTYSHFWRMIWHETTTPAVIVMLTQTHEASREKCYPYYPQSLETPTMRLNAQDEYEDSFIHELHLANLEEDQEARAQIRELHMTSEGSADSRTVWHLLFGGWPDFLVPEGADRAALLRLIAMSREKNADNATNPRIVHCSAGVGRSGTFIALDWLLQELDDGSLDEVADTEDPVFGVVSRLREQRMMMVQSEPQLAFIYDVIRERWRERWISQHEEEAEKMGVTRRRSDATPEGPSLKRQKSGYGREGDEDERAQLEAELFSNAEME</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C6U1</accession>
    <name>A0A177C6U1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Probable vacuolar protein sorting-associated protein 16 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CC84DRAFT_970635</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Essential for vacuolar protein sorting. Required for vacuole biogenesis, stability and to maintain vacuole morphology.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the VPS16 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG03363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033728.1">
        <property type="nucleotide sequence ID" value="XM_018188010.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C6U1"/>
    <dbReference type="FunCoup" id="A0A177C6U1">
        <property type="interactions" value="1058"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177C6U1"/>
    <dbReference type="GeneID" id="28771496"/>
    <dbReference type="InParanoid" id="A0A177C6U1"/>
    <dbReference type="OrthoDB" id="1792at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030897">
        <property type="term" value="C:HOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042144">
        <property type="term" value="P:vacuole fusion, non-autophagic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000635">
        <property type="entry name" value="Probable vacuolar protein sorting-associated protein 16 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.780">
        <property type="entry name" value="Vps16, C-terminal region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016534">
        <property type="entry name" value="VPS16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006925">
        <property type="entry name" value="Vps16_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038132">
        <property type="entry name" value="Vps16_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006926">
        <property type="entry name" value="Vps16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12811">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING VPS16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12811:SF0">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 16 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04840">
        <property type="entry name" value="Vps16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04841">
        <property type="entry name" value="Vps16_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007949">
        <property type="entry name" value="VPS16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0653">Protein transport</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Vps16 N-terminal" evidence="4">
        <location>
            <begin position="4"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="Vps16 C-terminal" evidence="3">
        <location>
            <begin position="501"/>
            <end position="822"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR007949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAG03363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="838" mass="93278" checksum="F8D384E0D8572BC4" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C7E0</accession>
    <name>A0A177C7E0_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="2 7">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CC84DRAFT_1166519</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the peptidase C12 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="2 7"/>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG02688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033053.1">
        <property type="nucleotide sequence ID" value="XM_018178980.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C7E0"/>
    <dbReference type="STRING" id="1460663.A0A177C7E0"/>
    <dbReference type="GeneID" id="28762466"/>
    <dbReference type="InParanoid" id="A0A177C7E0"/>
    <dbReference type="OrthoDB" id="1924260at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.532.10">
        <property type="entry name" value="Peptidase C12, ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001578">
        <property type="entry name" value="Peptidase_C12_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036959">
        <property type="entry name" value="Peptidase_C12_UCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10589">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10589:SF29">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01088">
        <property type="entry name" value="Peptidase_C12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52048">
        <property type="entry name" value="UCH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="4 7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UCH catalytic" evidence="9">
        <location>
            <begin position="125"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="284"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="62"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="88"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="7">
        <location>
            <position position="204"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="331"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="7">
        <location>
            <position position="197"/>
        </location>
    </feature>
    <feature type="site" description="Important for enzyme activity" evidence="7">
        <location>
            <position position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS52048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAG02688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="534" mass="59716" checksum="52DD0341EB7D1D5F" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C7K9</accession>
    <name>A0A177C7K9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1248848</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG03633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033998.1">
        <property type="nucleotide sequence ID" value="XM_018184269.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C7K9"/>
    <dbReference type="GeneID" id="28767755"/>
    <dbReference type="InParanoid" id="A0A177C7K9"/>
    <dbReference type="OrthoDB" id="4364812at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG03633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="298" mass="33896" checksum="8D7A8DAC2215E21E" modified="2016-09-07" version="1">MVPPRMGTRDVPPFGSQPFDHFIMERWDPSSTLSKKEQHKVLVAVWLSLGQYGRNIFYQRMRTWANDSDIPEHVPQDLLTNEQRAKNEVPYCAFWIRTWYGTEDKGSDGSKPVTRATANKCYHHLYRRAVLSIEEDGDENEPYDGDLTIEEDAIFDDDPDSFGMAQQTPEEDIAPAGAIPSALAGAFMRVPDSFDGTSKAEWRSDNAEMILKEEKRLEDSQHVLVLLADRQACERGWVLFLSINHKGQVMPLRIRHKAGDTRDQVNQWLGLGHGIDAAPEDRTDEVIYADDGDGWDKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C7Z8</accession>
    <name>A0A177C7Z8_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 11">Triosephosphate isomerase</fullName>
            <ecNumber evidence="6 11">5.3.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CC84DRAFT_935889</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>D-glyceraldehyde 3-phosphate = dihydroxyacetone phosphate</text>
            <dbReference type="Rhea" id="RHEA:18585"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="5.3.1.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 11">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate from glycerone phosphate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 11">Belongs to the triosephosphate isomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.1" evidence="6 11"/>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG02877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033242.1">
        <property type="nucleotide sequence ID" value="XM_018187912.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C7Z8"/>
    <dbReference type="FunCoup" id="A0A177C7Z8">
        <property type="interactions" value="685"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177C7Z8"/>
    <dbReference type="GeneID" id="28771398"/>
    <dbReference type="InParanoid" id="A0A177C7Z8"/>
    <dbReference type="OrthoDB" id="6715177at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00189"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004807">
        <property type="term" value="F:triose-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046166">
        <property type="term" value="P:glyceraldehyde-3-phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019563">
        <property type="term" value="P:glycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00311">
        <property type="entry name" value="TIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000025">
        <property type="entry name" value="Triosephosphate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00147_B">
        <property type="entry name" value="TIM_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035990">
        <property type="entry name" value="TIM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022896">
        <property type="entry name" value="TrioseP_Isoase_bac/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000652">
        <property type="entry name" value="Triosephosphate_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020861">
        <property type="entry name" value="Triosephosphate_isomerase_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00419">
        <property type="entry name" value="tim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21139">
        <property type="entry name" value="TRIOSEPHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21139:SF41">
        <property type="entry name" value="TRIOSEPHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00121">
        <property type="entry name" value="TIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51351">
        <property type="entry name" value="Triosephosphate isomerase (TIM)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00171">
        <property type="entry name" value="TIM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51440">
        <property type="entry name" value="TIM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="9 11" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="10 11 12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00019397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OAG02877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="249" mass="26959" checksum="809F66B0CAAA01CC" modified="2016-09-07" version="1">MGRQFFIGGNFKMYVTSRASITEIIDNLNKAKIDENAEVVIAPPSLYLLLAREHLRKGIEVAAQNVFDKPNGAFTGEISAQQLKESGITWTLVGHSERRVILQEDDAFVASKTKAALDGGLGVILCCGESLEQREAGKTIEVVTNQLKAVADKVKDWSKIVIAYEPIWAIGTGKVATTEQAQEVHAAIREWLKKDVSSEAAEKTRILYGGSVTEKNSPELAKQADIDGFLVGGASLKPAFVDIINSNSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C819</accession>
    <name>A0A177C819_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1166778</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG02999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033364.1">
        <property type="nucleotide sequence ID" value="XM_018179047.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C819"/>
    <dbReference type="GeneID" id="28762533"/>
    <dbReference type="InParanoid" id="A0A177C819"/>
    <dbReference type="OrthoDB" id="10553023at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG02999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="59" mass="7083" checksum="9D6F313A3A046D60" modified="2016-09-07" version="1">MVRKAAPLPERARLKQEQDLTRWQRDLRAKAEAILDSLDMRSLDFEDNYRELGGRYFRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C820</accession>
    <name>A0A177C820_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1260872</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG03793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034158.1">
        <property type="nucleotide sequence ID" value="XM_018185020.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C820"/>
    <dbReference type="GeneID" id="28768506"/>
    <dbReference type="InParanoid" id="A0A177C820"/>
    <dbReference type="OrthoDB" id="10250354at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="1">
        <location>
            <begin position="10"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG03793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="57" mass="6394" checksum="8D86492E8E273090" modified="2016-09-07" version="1">MAPFKPSTEDFYFELGIIQIATQAEIKLAYRKLALLGHPDKTGCVKDDADFKSVYKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C830</accession>
    <name>A0A177C830_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Subtilisin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CC84DRAFT_867468</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the peptidase S8 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG03803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034168.1">
        <property type="nucleotide sequence ID" value="XM_018187717.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C830"/>
    <dbReference type="STRING" id="1460663.A0A177C830"/>
    <dbReference type="GeneID" id="28771203"/>
    <dbReference type="InParanoid" id="A0A177C830"/>
    <dbReference type="OrthoDB" id="206201at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04077">
        <property type="entry name" value="Peptidases_S8_PCSK9_ProteinaseK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.200:FF:000014">
        <property type="entry name" value="Proteinase K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.80">
        <property type="entry name" value="Peptidase S8 propeptide/proteinase inhibitor I9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034193">
        <property type="entry name" value="PCSK9_ProteinaseK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050131">
        <property type="entry name" value="Peptidase_S8_subtilisin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010259">
        <property type="entry name" value="S8pro/Inhibitor_I9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037045">
        <property type="entry name" value="S8pro/Inhibitor_I9_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806:SF58">
        <property type="entry name" value="ALKALINE PROTEASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806">
        <property type="entry name" value="PEPTIDASE S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05922">
        <property type="entry name" value="Inhibitor_I9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6 7" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0720">Serine protease</keyword>
    <keyword evidence="3 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008057815" evidence="8">
        <location>
            <begin position="21"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="Inhibitor I9" evidence="10">
        <location>
            <begin position="33"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S8/S53" evidence="9">
        <location>
            <begin position="158"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="160"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="191"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OAG03803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="408" mass="41926" checksum="B7920277DAA1235B" modified="2016-09-07" version="1">MLNVGRLAFLFGALLPSALAAPVTKKSDLIEGKYIVTLKPEAEVQVQVSWVNDVHKRSFSKRDTAGVEHTYDIKTFKGYAGEFDENTLAEIKANPNVAAVEPDQLVYLPFKVEQVFDKRALTTQTGAPWGLGAISHKTGSSTSYVYDSTAGQDTYAYVVDSGIITTHTEFGGRASLGYNAVGGQHTDTLGHGTHVAGTIGGSTYGVAKKTNLISVKVFQGATGSQSTILAGFDWAVNDIVSKNRASKSVINMSLGGGASTAWTNAIAASYQQGVLSVVAAGNGDQNGNPLPVSGQSPANAPNAITVSAADSSFRVASFANYGAGVDVFAPGVNVLSSYIGGNSATASLSGTSMATPHTAGLAVYLMALEGLASPAAVTNRIKALAVTGKVTGSLSGSPNVFIYNGNGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C972</accession>
    <name>A0A177C972_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1166988</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG03270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033635.1">
        <property type="nucleotide sequence ID" value="XM_018179099.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C972"/>
    <dbReference type="STRING" id="1460663.A0A177C972"/>
    <dbReference type="GeneID" id="28762585"/>
    <dbReference type="InParanoid" id="A0A177C972"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG03270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="93" mass="10397" checksum="5ED73A92EBA3E0C3" modified="2016-09-07" version="1">MTDRVLRLPRSTSRYYAAPAIDSDHAPWSQNQGGFHQSEIVCILNALCANADTYAFTEYDYYFGGVMSDYWANFVKTLDPIIVGSGYGGNLTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C9F6</accession>
    <name>A0A177C9F6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CC84DRAFT_1120767</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG04384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034749.1">
        <property type="nucleotide sequence ID" value="XM_018175591.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C9F6"/>
    <dbReference type="GeneID" id="28759077"/>
    <dbReference type="InParanoid" id="A0A177C9F6"/>
    <dbReference type="OrthoDB" id="2213137at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF287">
        <property type="entry name" value="MFS MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="194"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="232"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="274"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="302"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="328"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="399"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="4">
        <location>
            <begin position="237"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAG04384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="431" mass="46853" checksum="8B1592EECCBDB882" modified="2016-09-07" version="1">MADATPASSEFELEDRGEELAQQLPPVDGGKDAWLFLAASFVIEALVWGFPFSFGVFQDYYSTHEPFAGSGNIAVIGTCAMGIMYLDLVMVFSLLKMWPSYQRWATSCGLFVMCLALALSSLSNNTGELIVSQGVIYAIGGSFTYSPCILYMDEWFHKRKGLAYGIMWAGTGLAGVILPLVMEWMLRDYGFRTTLRVWAICLFVLTAPLLYFVKPRIPIAPKQRARKIDFSFLKTSTFTIHQACNTIEALGFFLPSIYLPTYARSIGASGTLSALTVILFNVASVFGCVAMGSIVDKWHVTTCILISTIGTTISVFIVWGFSMSLAPLYVFCLIYGFFAGSFTSAWPGIMRDVTKKRQTADPSIVFACLAAGRGIGNVASGPLSEVLIRGLPWKDSVGFAYGSGYGTLIVFTGVTALLGGSSILGKRVGWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CA89</accession>
    <name>A0A177CA89_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">TPR-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1188352</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG03762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034127.1">
        <property type="nucleotide sequence ID" value="XM_018180984.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CA89"/>
    <dbReference type="STRING" id="1460663.A0A177CA89"/>
    <dbReference type="GeneID" id="28764470"/>
    <dbReference type="InParanoid" id="A0A177CA89"/>
    <dbReference type="OrthoDB" id="5986190at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053137">
        <property type="entry name" value="NLR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082:SF11">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082">
        <property type="entry name" value="ATP/GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13374">
        <property type="entry name" value="TPR_10"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG03762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="194" mass="22181" checksum="14DC05ABB60EBD88" modified="2016-09-07" version="1">MALYSDGRYKEAEELFVQVMEMSKRVLGEEHPDTLLSMGNLASTYRNQGRWKEAEELSVQVMETRKRVLGEEHPDMLLSMGNLASTKRVVGEEHPDTLLSMGNLASTYRNQGRWKEAEELEVQRVLGEEHPDTLLSISNFAFTLQTQARQKEAFALMERCFLLRQQILGEQHPDTQSSLDTLASWRADCSDELS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CAM4</accession>
    <name>A0A177CAM4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ubiquitin 3 binding protein But2 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_791898</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG04426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034791.1">
        <property type="nucleotide sequence ID" value="XM_018187410.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CAM4"/>
    <dbReference type="GeneID" id="28770896"/>
    <dbReference type="InParanoid" id="A0A177CAM4"/>
    <dbReference type="OrthoDB" id="3755713at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008057945" description="Ubiquitin 3 binding protein But2 C-terminal domain-containing protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG04426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="171" mass="18427" checksum="0E17DE01ECEADF12" modified="2016-09-07" version="1">MYLPTFLILGLSATVSALPPTSRRACTSYRTVSDPGFYASASLPSADFPDDPPYFENQILEFQPSFTSTSTCTLFGNFERGFPVRVDGNAAPKLNVYQRHSSTDKKLVGTFAALELDEQGETTDIVSSPIATFKCQEGTVFEFEVALSGAGSWASVAFEEDAESGFSVLAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CAU7</accession>
    <name>A0A177CAU7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Phospholipase D/nuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CC84DRAFT_1095526</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the tyrosyl-DNA phosphodiesterase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG03959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034324.1">
        <property type="nucleotide sequence ID" value="XM_018174619.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CAU7"/>
    <dbReference type="FunCoup" id="A0A177CAU7">
        <property type="interactions" value="455"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CAU7"/>
    <dbReference type="GeneID" id="28758105"/>
    <dbReference type="InParanoid" id="A0A177CAU7"/>
    <dbReference type="OrthoDB" id="47785at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017005">
        <property type="term" value="F:3'-tyrosyl-DNA phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09123">
        <property type="entry name" value="PLDc_Tdp1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09194">
        <property type="entry name" value="PLDc_yTdp1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.870.10:FF:000038">
        <property type="entry name" value="Probable tyrosyl-DNA phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.870.10">
        <property type="entry name" value="Endonuclease Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010347">
        <property type="entry name" value="Tdp1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12415">
        <property type="entry name" value="TYROSYL-DNA PHOSPHODIESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12415:SF0">
        <property type="entry name" value="TYROSYL-DNA PHOSPHODIESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06087">
        <property type="entry name" value="Tyr-DNA_phospho"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56024">
        <property type="entry name" value="Phospholipase D/nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="9">
        <location>
            <position position="207"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="9">
        <location>
            <position position="469"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="471"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="11">
        <location>
            <position position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR610347-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR610347-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR610347-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OAG03959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="611" mass="67890" checksum="90508B890BFA40BF" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CC33</accession>
    <name>A0A177CC33_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1218580</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG05213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035578.1">
        <property type="nucleotide sequence ID" value="XM_018183012.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CC33"/>
    <dbReference type="STRING" id="1460663.A0A177CC33"/>
    <dbReference type="GeneID" id="28766498"/>
    <dbReference type="InParanoid" id="A0A177CC33"/>
    <dbReference type="OrthoDB" id="10250354at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="27"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="200"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG05213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="224" mass="25248" checksum="3CA28EFC6C572C9F" modified="2016-09-07" version="1">MSLPRTFCLSSASAALTPSTILTSFPNHYEVMKLSPSASTEDVKAQFRTLRGEYFASDAGKYRQLQTAYAVLVDSEARREYDELYRASMGLPVQPVANDPLESSGSASPSLRKSALVKAAVSRIDAQSQEPSREEQQRLAGEELRLRQEKENEEERRRRAEEQRQREADPNYGLKHFTPVYVPLIGSQPYHSYVPVAAEHEGMERKRKSRRPMYVGKLAAKAVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CCB9</accession>
    <name>A0A177CCB9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Large ribosomal subunit protein eL24-related N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CC84DRAFT_1218367</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL24 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG04966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035331.1">
        <property type="nucleotide sequence ID" value="XM_018182988.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CCB9"/>
    <dbReference type="FunCoup" id="A0A177CCB9">
        <property type="interactions" value="856"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CCB9"/>
    <dbReference type="GeneID" id="28766474"/>
    <dbReference type="InParanoid" id="A0A177CCB9"/>
    <dbReference type="OrthoDB" id="1727108at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00472">
        <property type="entry name" value="Ribosomal_L24e_L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.170.20:FF:000002">
        <property type="entry name" value="60S ribosomal protein L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.170.20">
        <property type="entry name" value="Ribosomal protein L24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038630">
        <property type="entry name" value="L24e/L24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056366">
        <property type="entry name" value="Ribosomal_eL24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000988">
        <property type="entry name" value="Ribosomal_eL24-rel_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023442">
        <property type="entry name" value="Ribosomal_eL24_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10792">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10792:SF1">
        <property type="entry name" value="RIBOSOMAL PROTEIN L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01246">
        <property type="entry name" value="Ribosomal_L24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01073">
        <property type="entry name" value="RIBOSOMAL_L24E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein eL24-related N-terminal" evidence="5">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="93"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="93"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAG04966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="159" mass="17819" checksum="181AB6293267F75B" modified="2016-09-07" version="1">MRTYDDSFSGEKIYPGKGKLYVRGDSKIFRFQNGKTESLFLQRKNPRRIAWTVLFRRQHKKGISEEVAKKRTRRTVKHQRAIVGASLDVIKERRSQRPEARSAARAAAIKEGKEKRAAAESKKKAEKAKSAAAGARGNVNKVSKQGAKGAAPKVQARTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CCT4</accession>
    <name>A0A177CCT4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1187878</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG04991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035356.1">
        <property type="nucleotide sequence ID" value="XM_018180960.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CCT4"/>
    <dbReference type="STRING" id="1460663.A0A177CCT4"/>
    <dbReference type="GeneID" id="28764446"/>
    <dbReference type="InParanoid" id="A0A177CCT4"/>
    <dbReference type="OrthoDB" id="419598at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052718">
        <property type="entry name" value="NmrA-type_oxidoreductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47129:SF1">
        <property type="entry name" value="NMRA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47129">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="1">
        <location>
            <begin position="3"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG04991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="319" mass="35323" checksum="CADD2808C0AA427E" modified="2016-09-07" version="1">MLALTSATGKLGKAVIDAVLENKLVDPSELVVCTSSDPLDARFDALRDQSITVRYNNFDQPESLERAFAGCSKLFLVSTPRISMDYNDAPLWQGREAHHRAAIDAAVKAGVKHIYYTSLAFGNPSKAGVMRAHIRTEKYLSDLADKGKVDYTIIREGLYNESWPLYFGYYFRLRDEKRHQVVVAGDGPISWTSIADMAFGTAQIISAPSDTWKGKTLYLSQTETCSLEDIARKVSSAQGQDIHLKVVSKKEYEDHYAASGTERASVEWWSSTYEALKNGECDIKDDTLKTMLREAGREPTSIDETIAKMLGGEGGQIVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CDE0</accession>
    <name>A0A177CDE0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Elongation factor 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CC84DRAFT_1147875</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Component of the NuA4 histone acetyltransferase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCF family. EF3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG04902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035267.1">
        <property type="nucleotide sequence ID" value="XM_018176608.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CDE0"/>
    <dbReference type="FunCoup" id="A0A177CDE0">
        <property type="interactions" value="245"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CDE0"/>
    <dbReference type="GeneID" id="28760094"/>
    <dbReference type="InParanoid" id="A0A177CDE0"/>
    <dbReference type="OrthoDB" id="2110130at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008079">
        <property type="term" value="F:translation termination factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006449">
        <property type="term" value="P:regulation of translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd03221">
        <property type="entry name" value="ABCF_EF-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18626">
        <property type="entry name" value="CD_eEF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000076">
        <property type="entry name" value="Elongation factor 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.990:FF:000002">
        <property type="entry name" value="mRNA export factor elf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000193">
        <property type="entry name" value="Probable Elongation factor 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050611">
        <property type="entry name" value="ABCF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015688">
        <property type="entry name" value="eEF3_ABC2_chromodomain-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047038">
        <property type="entry name" value="eEF3_chromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211:SF14">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY F MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211">
        <property type="entry name" value="ATP-BINDING TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24984">
        <property type="entry name" value="HEAT_EF3_GNC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24987">
        <property type="entry name" value="HEAT_EF3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="485"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="729"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1057"/>
            <end position="1126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1081"/>
            <end position="1091"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAG04902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="1126" mass="123898" checksum="10A021FBF5847C03" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CDN7</accession>
    <name>A0A177CDN7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1165247</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG04878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035243.1">
        <property type="nucleotide sequence ID" value="XM_018178673.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CDN7"/>
    <dbReference type="GeneID" id="28762159"/>
    <dbReference type="InParanoid" id="A0A177CDN7"/>
    <dbReference type="OrthoDB" id="10534066at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG04878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="161" mass="18249" checksum="F734EBBBC0E4E9E4" modified="2016-09-07" version="1">MSPSKMIPTHVLLESTPRLDQLATSIDLRGRKRVPVKEDTTLYIYDMPEQCADMVTEIHSIRSAIEAAIDWADIQKPTVLPQFFRMTSGVIKVKENHTVIIKAVGDPEDLAEARLRSWPLFQDESVTETKPLSSLALIRPLDSTQCLQYNTERRKANEGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CE28</accession>
    <name>A0A177CE28_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cytochrome P450 monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CC84DRAFT_818715</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG05038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035403.1">
        <property type="nucleotide sequence ID" value="XM_018187529.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CE28"/>
    <dbReference type="STRING" id="1460663.A0A177CE28"/>
    <dbReference type="GeneID" id="28771015"/>
    <dbReference type="InParanoid" id="A0A177CE28"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11058">
        <property type="entry name" value="CYP60B-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF210">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE ASQL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 7" id="KW-0349">Heme</keyword>
    <keyword evidence="5 6 7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="16"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="6">
        <location>
            <position position="448"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAG05038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="510" mass="57524" checksum="11183B2D1EA4EDD1" modified="2016-09-07" version="1">MAAIEPDVRHLEPTSIALAILAVSFLYLLGLCIYRRYFHPLAKFPGPFLNSVSELPAALSLLRGRYAFDNKLHHEHYGDVVRIGPNELTFRTSQSIQDIYGFRPGHQNMKKSFLHTGPVKVGQTTTLQYVPSDADHGRQRRALSHAFSHQALMDQEPIIQDYMSKVVSRLRKFARDSQVVDICDWFNYFTFDTMGDLAFGESFGCLDEGKYQEWVDMLFMTIKDGTLIQFSRRIGGIGTWAQTVLARILGVGDAGSYHVHHTRQKVLSRLAMQDIDHRDFIWYILRQKEKGFELTQDEIIANAGLFIVAGSETTANALSGLIARLIWNPRVYEKLVTEIRGAFHDEAAIDFKAITALPYLNACIEEVLRVHPPVPAGPPRVVPPGGDTVDGVYVPGGTTVSVGQWSACHNPAHFKNPDEFLPERWIDPAYNSEVKKAVQPFSAGPRNCIGKNLAYMEMRLVVAHLLWNFDIVSVDGAPLWDPAGEMRHKRAFMVWEKQPLMLHLKDVRIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CE48</accession>
    <name>A0A177CE48_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">alpha-glucosidase</fullName>
            <ecNumber evidence="3">3.2.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_1118684</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing (1-&gt;4)-linked alpha-D-glucose residues with release of alpha-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.20"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the glycosyl hydrolase 31 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.20" evidence="3"/>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG05491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035856.1">
        <property type="nucleotide sequence ID" value="XM_018175525.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CE48"/>
    <dbReference type="STRING" id="1460663.A0A177CE48"/>
    <dbReference type="GeneID" id="28759011"/>
    <dbReference type="InParanoid" id="A0A177CE48"/>
    <dbReference type="OrthoDB" id="1334205at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004558">
        <property type="term" value="F:alpha-1,4-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006491">
        <property type="term" value="P:N-glycan processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06595">
        <property type="entry name" value="GH31_u1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048395">
        <property type="entry name" value="Glyco_hydro_31_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000322">
        <property type="entry name" value="Glyco_hydro_31_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762">
        <property type="entry name" value="ALPHA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762:SF89">
        <property type="entry name" value="ALPHA-XYLOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01055">
        <property type="entry name" value="Glyco_hydro_31_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21365">
        <property type="entry name" value="Glyco_hydro_31_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase family 31 TIM barrel" evidence="6">
        <location>
            <begin position="201"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 31 C-terminal" evidence="7">
        <location>
            <begin position="516"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="658"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="865"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF21365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAG05491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="865" mass="97138" checksum="7F048743034BB0FB" modified="2016-09-07" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CFA9</accession>
    <name>A0A177CFA9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ferric-chelate reductase (NADPH)</fullName>
            <ecNumber evidence="3">1.16.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CC84DRAFT_1120073</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>2 a Fe(II)-siderophore + NADP(+) + H(+) = 2 a Fe(III)-siderophore + NADPH</text>
            <dbReference type="Rhea" id="RHEA:28795"/>
            <dbReference type="Rhea" id="RHEA-COMP:11342"/>
            <dbReference type="Rhea" id="RHEA-COMP:11344"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.16.1.9"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ferric reductase (FRE) family.</text>
    </comment>
    <dbReference type="EC" id="1.16.1.9" evidence="3"/>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG06275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036640.1">
        <property type="nucleotide sequence ID" value="XM_018175570.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CFA9"/>
    <dbReference type="STRING" id="1460663.A0A177CFA9"/>
    <dbReference type="GeneID" id="28759056"/>
    <dbReference type="InParanoid" id="A0A177CFA9"/>
    <dbReference type="OrthoDB" id="10006946at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052851">
        <property type="term" value="F:ferric-chelate reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015677">
        <property type="term" value="P:copper ion import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013112">
        <property type="entry name" value="FAD-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051410">
        <property type="entry name" value="Ferric/Cupric_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361:SF9">
        <property type="entry name" value="FERRIC REDUCTASE TRANSMEMBRANE COMPONENT 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361">
        <property type="entry name" value="FERRIC/CUPRIC REDUCTASE TRANSMEMBRANE COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08022">
        <property type="entry name" value="FAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00052">
        <property type="entry name" value="Ferric_Reductase_Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01168">
        <property type="entry name" value="Ferric_reductase_subgroup_(FRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="28"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="172"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="207"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="235"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="15">
        <location>
            <begin position="258"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OAG06275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="601" mass="67140" checksum="7189FFCBD3FF62AE" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CFZ1</accession>
    <name>A0A177CFZ1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Tryptophan synthase beta subunit-like PLP-dependent enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CC84DRAFT_1164778</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the serine/threonine dehydratase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG06525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036890.1">
        <property type="nucleotide sequence ID" value="XM_018178560.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CFZ1"/>
    <dbReference type="FunCoup" id="A0A177CFZ1">
        <property type="interactions" value="1147"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CFZ1"/>
    <dbReference type="GeneID" id="28762046"/>
    <dbReference type="InParanoid" id="A0A177CFZ1"/>
    <dbReference type="OrthoDB" id="271064at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008721">
        <property type="term" value="F:D-serine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003941">
        <property type="term" value="F:L-serine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030378">
        <property type="term" value="F:serine racemase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018114">
        <property type="term" value="F:threonine racemase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01562">
        <property type="entry name" value="Thr-dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000005">
        <property type="entry name" value="Threonine dehydratase catabolic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43050">
        <property type="entry name" value="SERINE / THREONINE RACEMASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43050:SF1">
        <property type="entry name" value="SERINE RACEMASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="5">
        <location>
            <begin position="61"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAG06525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="403" mass="42942" checksum="6B5812B55908F10A" modified="2016-09-07" version="1">MGSHVELPLTRESVIAAHDLIKPNIHLTPVQTNTTLSNLASTPQTAEALKGTPWEGQEPARPKIKLFFKCENFQRIGAFKVRGAFHAVKRLIEREGLEEVRRKGVVTHSSGNHAQALALAAKTFDIPAHIVMPKISTPSKIAGTQAQGAIVHFSGSTSQEREAVVADVIKDTGATLVPPYDHPHIILGQGTMALELTEQASSLIASDPWLSVREGKTGLDAVIAPCGGGGMLAGNAVALHGTGVKVFAAEPEFEGGDDARRGVAAGERITTVKTLTIADGLRTPLGETNWKIVADPSYVHSLHSVTEDNIRDAMRLVLERMKCFVEPSAVVGLATILYNEDFRRVVEKEAGEEGWNIGVIFSGGNTTIEAITKIFAPVGEAKAVREQGVVGQDGKRVAENVAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CG34</accession>
    <name>A0A177CG34_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1092114</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG06296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036661.1">
        <property type="nucleotide sequence ID" value="XM_018174434.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CG34"/>
    <dbReference type="GeneID" id="28757920"/>
    <dbReference type="InParanoid" id="A0A177CG34"/>
    <dbReference type="OrthoDB" id="5394254at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="274"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="301"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG06296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="330" mass="35954" checksum="3A46F5A4EB33275B" modified="2016-09-07" version="1">MADRPPPTVVPRASRRARLPSFVRLPMLIILNICLQSALWTGAENVLSHELGAVSKVPRPGQEQEGFGELTEPIVRLVSKIALVSVAWKLRYDYFDIGALTAVINIPFAFLLTTFYNISLLTAAAHVAIEVISIALPTYLLRPIADINNPAVPIRNRYLLNSFQVSWSNTALAVGVYATVLYSSLQTNWLTIFLINHFDLPSVELAHDVQAATFIPKLLVAGYATKAFLLDPAIGAQPETGAVTPVGPFEPATATLPQTLKHNFWFFSRRTRTLIQRSAVLSTFLLANTVLRGATLEGSEIAGSAGYAGVWILAANICAAWFVWTGDADP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CH42</accession>
    <name>A0A177CH42_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Alpha-ketoglutarate-dependent sulfonate dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CC84DRAFT_1119637</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TfdA dioxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG06027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036392.1">
        <property type="nucleotide sequence ID" value="XM_018175558.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CH42"/>
    <dbReference type="STRING" id="1460663.A0A177CH42"/>
    <dbReference type="GeneID" id="28759044"/>
    <dbReference type="InParanoid" id="A0A177CH42"/>
    <dbReference type="OrthoDB" id="10257314at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016706">
        <property type="term" value="F:2-oxoglutarate-dependent dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.130.10:FF:000005">
        <property type="entry name" value="TfdA family taurine dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051323">
        <property type="entry name" value="AtsK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT SULFONATE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468:SF10">
        <property type="entry name" value="TAUD_TFDA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="8">
        <location>
            <begin position="50"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="25"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAG06027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="372" mass="41249" checksum="5D16BC2A7C1689DE" modified="2016-09-07" version="1" fragment="single">MAPPAADLDLSVRPVEHQAPPKVRSKGESGSRLEKPLVSSSSLEQYEHANVTPVIGEEFPKLQLSDILHDDTKVRDLAILVSQRGVVFFRNQNLNIDDQKILGQRLGELTGKPETSKLHRHALSNSKRGIAVDENGKLDDEVSVISSDQNRTFYADRFGANSKRLASEGWHADITFERIPSDYAILKVHTLPADGAGGDTLWASGYEAYDRLSPPLQKFAEGLTATHHQPNFNRVAAEFGAELISTSRGSPENTGLDFAASHPVVRTNPVTGWKSLFGAGHQLEHGWIDGVTARESEILKGYFLQVVVENHDLQVRFRWRENDVAIWDNRSVFHTATNDYAGKRQGNRVVGLGEKPFYDPGSVSRREALARE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CIU1</accession>
    <name>A0A177CIU1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PEBP-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1241700</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG06892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037257.1">
        <property type="nucleotide sequence ID" value="XM_018184060.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CIU1"/>
    <dbReference type="STRING" id="1460663.A0A177CIU1"/>
    <dbReference type="GeneID" id="28767546"/>
    <dbReference type="InParanoid" id="A0A177CIU1"/>
    <dbReference type="OrthoDB" id="2506647at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030414">
        <property type="term" value="F:peptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030162">
        <property type="term" value="P:regulation of proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046578">
        <property type="term" value="P:regulation of Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00866">
        <property type="entry name" value="PEBP_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.280.10">
        <property type="entry name" value="PEBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008914">
        <property type="entry name" value="PEBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036610">
        <property type="entry name" value="PEBP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035810">
        <property type="entry name" value="PEBP_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11362">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11362:SF78">
        <property type="entry name" value="PROTEASE INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01161">
        <property type="entry name" value="PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49777">
        <property type="entry name" value="PEBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG06892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="220" mass="23177" checksum="88018465D9EFF827" modified="2016-09-07" version="1">MPSPTPTIKKFLDQNKDNTAPSLLITFPSGTQIPAPATKASKSNTARAPTFSVTQSCLRTHLPGAKYIALALDLDAPSPALPLASPVLHCLHTDLVAATASPFAAAPSSSSPIFKTDTATDTWVQLTPSSVAAGGEGTLEKPLASWVAPAPPGFSAPHRYVFLVWEQPEKMSGEEVRRKMGWGKGEIGLWGKVRFDVEGFVRRVGAGEIVAGTWMVVGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CIW8</accession>
    <name>A0A177CIW8_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CC84DRAFT_620676</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG06770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037135.1">
        <property type="nucleotide sequence ID" value="XM_018186910.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CIW8"/>
    <dbReference type="STRING" id="1460663.A0A177CIW8"/>
    <dbReference type="GeneID" id="28770396"/>
    <dbReference type="InParanoid" id="A0A177CIW8"/>
    <dbReference type="OrthoDB" id="10009520at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="10">
        <location>
            <begin position="887"/>
            <end position="1125"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="9">
        <location>
            <begin position="891"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="1012"/>
            <end position="1039"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OAG06770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1155" mass="130235" checksum="E3F87BF0AFA16AB4" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CJ50</accession>
    <name>A0A177CJ50_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1089431</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG07291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037656.1">
        <property type="nucleotide sequence ID" value="XM_018174307.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CJ50"/>
    <dbReference type="STRING" id="1460663.A0A177CJ50"/>
    <dbReference type="GeneID" id="28757793"/>
    <dbReference type="InParanoid" id="A0A177CJ50"/>
    <dbReference type="OrthoDB" id="5411678at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG07291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="278" mass="29299" checksum="ADA435635754A23C" modified="2016-09-07" version="1" fragment="single">NPTNSAASPTSSAASSTDPASLQNPQNKHETGGLSPAGKTAIAVVIPVVAVALLLLAGLWFWRKRKSKKSAEEARRKEVEEYGFNPNEDPTLPAVGMQSEMAEDQSGYRGWGNTATSSNRKASTTLTSGMTYSDSNSNPGDVYANPGSPTHAYSDAHSADPLVNGRRETLDSDGIGALGAAPVAGQNQAGVARGPSNASSSYSAAERSDHSGDYPLPMNHPQEYYDNNGYYPSSGPYDNSYGGGQQPIIRDVSARRNTRIENPSVFPQQGNSGIAQNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CL02</accession>
    <name>A0A177CL02_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Putative transcription factor kapC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CC84DRAFT_1185151</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Putative transcription factor.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the bZIP family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038589.1">
        <property type="nucleotide sequence ID" value="XM_018180788.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CL02"/>
    <dbReference type="STRING" id="1460663.A0A177CL02"/>
    <dbReference type="GeneID" id="28764274"/>
    <dbReference type="InParanoid" id="A0A177CL02"/>
    <dbReference type="OrthoDB" id="2593073at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090575">
        <property type="term" value="C:RNA polymerase II transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050936">
        <property type="entry name" value="AP-1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40621">
        <property type="entry name" value="TRANSCRIPTION FACTOR KAPC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40621:SF11">
        <property type="entry name" value="TRANSCRIPTION FACTOR KAPC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="11">
        <location>
            <begin position="103"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="82"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="167"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="116"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="104"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="183"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="265"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS00036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OAG08224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="283" mass="30986" checksum="8EB156F067C5BB48" modified="2016-09-07" version="1">MPTALPTLYPSIRTYNMQQPPATHDPKAPTIEMSLREHLLAAGAGQSSAPQPMQQHPHQSPQQHAIDPAIAGQQYQMSQGETAHMGDQGQANAKGRRELSTSKRAAQNRAAQRAFRQRKEEYIKQLKDQVKEFEQLCELYKTLQTENYQLRDYIINLQSRLLETQGEVPPAPAGVDLSRHGEAPNPNMNQAPPQPQPDHQAQSQQNTNNSSNNGGLSDRQIGELQMAAQAAAAAQHGGPSLSNGKHPNDGSPFSGDYADKRQKTGDSPASGQQFQSPYPNPYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CL44</accession>
    <name>A0A177CL44_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1090194</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG07588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037953.1">
        <property type="nucleotide sequence ID" value="XM_018174345.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CL44"/>
    <dbReference type="STRING" id="1460663.A0A177CL44"/>
    <dbReference type="GeneID" id="28757831"/>
    <dbReference type="InParanoid" id="A0A177CL44"/>
    <dbReference type="OrthoDB" id="2744543at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052523">
        <property type="entry name" value="Trichothecene_AcTrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791">
        <property type="entry name" value="GNAT FAMILY ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791:SF16">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="158"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG07588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="232" mass="26309" checksum="78CCCE7A78AE6A34" modified="2016-09-07" version="1">MASDTAKPGSPRNVQVRTAQLSDLPAMARVWHAAFFDDEIIGKLMHPHRKEHPEDVYWFLLRGLRERFWDWHHQFVVVTVEEDGKERVAGAADWRRLGEGGRRRELARVDPRNLISPALHYYHAVSLRLFPNRAADPKNAEWLDEAVSNSEKHWTGDRAECWDLHVCGVHPDFQGKGVGKLLVQWGVKQAESEGDNVVASVLCGEKNRGFYGKGGLTVQVSKSEHGIALFTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CLM1</accession>
    <name>A0A177CLM1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ecp2 effector protein-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1205124</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG07719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038084.1">
        <property type="nucleotide sequence ID" value="XM_018181953.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CLM1"/>
    <dbReference type="STRING" id="1460663.A0A177CLM1"/>
    <dbReference type="GeneID" id="28765439"/>
    <dbReference type="InParanoid" id="A0A177CLM1"/>
    <dbReference type="OrthoDB" id="73875at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029226">
        <property type="entry name" value="Ecp2-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14856">
        <property type="entry name" value="Hce2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ecp2 effector protein-like" evidence="1">
        <location>
            <begin position="191"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG07719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="228" mass="24490" checksum="F1166077B5215970" modified="2016-09-07" version="1">MSGGKLTVFGFGIPALWSYSNAYAFVIDSGYGCDEAKEKLEKYIDAEMVDVTGVCIDGKMYYLGRVDGKSTECKCEITGDHGPCQTTCWDKKFTAPLGVEELNGEQCGGIKLEDLVKGSVNTYNQNGGRNGGAALNVDGDGAFDALLNVNVTTLGMVRLSVCSPERAFQAWGAQDMGNKLYPCNDVPGKNDCGDLDFEDQTSDASPSVDDCCQIIKNIQGDSMTEWTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CLU1</accession>
    <name>A0A177CLU1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1173418</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG07820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038185.1">
        <property type="nucleotide sequence ID" value="XM_018180035.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CLU1"/>
    <dbReference type="GeneID" id="28763521"/>
    <dbReference type="InParanoid" id="A0A177CLU1"/>
    <dbReference type="OrthoDB" id="3804371at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008058350" evidence="1">
        <location>
            <begin position="17"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG07820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="140" mass="15035" checksum="4A4894AE6BD77E24" modified="2016-09-07" version="1">MHTSLPLLALLPVAAASIWGTCTPQTTQTPPVSTRTYPTTLTEIHSCILNFSAVVPPFFDRTQFSNLDQTLTTLAPFPRAPTSIPWTHAVTVEGVLSRTEWVGGGLVQTFVSSVTDVETVVLDTSMALEAEATPVDLEAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CLU5</accession>
    <name>A0A177CLU5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Arabinanase/levansucrase/invertase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CC84DRAFT_1256811</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 32 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG07838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038203.1">
        <property type="nucleotide sequence ID" value="XM_018184663.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CLU5"/>
    <dbReference type="STRING" id="1460663.A0A177CLU5"/>
    <dbReference type="GeneID" id="28768149"/>
    <dbReference type="InParanoid" id="A0A177CLU5"/>
    <dbReference type="OrthoDB" id="202537at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004575">
        <property type="term" value="F:sucrose alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005987">
        <property type="term" value="P:sucrose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18621">
        <property type="entry name" value="GH32_XdINV-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.560">
        <property type="entry name" value="Exo-inulinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001362">
        <property type="entry name" value="Glyco_hydro_32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013189">
        <property type="entry name" value="Glyco_hydro_32_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013148">
        <property type="entry name" value="Glyco_hydro_32_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42800">
        <property type="entry name" value="EXOINULINASE INUD (AFU_ORTHOLOGUE AFUA_5G00480)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42800:SF3">
        <property type="entry name" value="GLYCOSYL HYDROLASE FAMILY 32 N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08244">
        <property type="entry name" value="Glyco_hydro_32C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00251">
        <property type="entry name" value="Glyco_hydro_32N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00640">
        <property type="entry name" value="Glyco_32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyl hydrolase family 32 N-terminal" evidence="5">
        <location>
            <begin position="50"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 32 C-terminal" evidence="6">
        <location>
            <begin position="467"/>
            <end position="597"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAG07838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="621" mass="69044" checksum="81089E5C507F9896" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CM03</accession>
    <name>A0A177CM03_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Kinase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CC84DRAFT_1046204</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG07807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038172.1">
        <property type="nucleotide sequence ID" value="XM_018173417.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CM03"/>
    <dbReference type="STRING" id="1460663.A0A177CM03"/>
    <dbReference type="GeneID" id="28756903"/>
    <dbReference type="InParanoid" id="A0A177CM03"/>
    <dbReference type="OrthoDB" id="10252171at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24347">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 4 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="1"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="25"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAG07807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="178" mass="20609" checksum="3EAD8FCB7C200A0A" modified="2016-09-07" version="1" fragment="single">IGSGEFGTVYRSVNVSTGVIYAAKKFLRNGKGHRERWDREVALLRNISHDHIVKFEDYDTERKWPRLIMEYLPLGNLAEHMPITEWETVTLLCQGLKALDYLHSRKIMHRDLKPENILVQCREPANFCIKIADFGLARDGSFLKTVCGTRLYAAPEIWQNRPYTSKVDIWSLGLIAFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2023-06-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CMB8</accession>
    <name>A0A177CMB8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_522536</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG07907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038272.1">
        <property type="nucleotide sequence ID" value="XM_018186619.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CMB8"/>
    <dbReference type="GeneID" id="28770105"/>
    <dbReference type="InParanoid" id="A0A177CMB8"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG07907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="193" mass="20650" checksum="9A6A0193C8A7836D" modified="2016-09-07" version="1">MVFVLVAGPGKSPSLSQLARRSLWGSCAQRAANHTHTLALNTAAIERGTGARVHDGESGRHSVAMPRQQGTATAPDGRDEDEGANGVGATQGTLVAWARPALPGSRGPKAVRREPRRGSKLFCQRRRDCEVDSASLLQVCLSRALEPRRRTHIDASTLPCPFARSQKYVSRFSRPIAPPSCALPLLPLVAPCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CMZ7</accession>
    <name>A0A177CMZ7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Kinase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CC84DRAFT_1240549</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039238.1">
        <property type="nucleotide sequence ID" value="XM_018184021.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CMZ7"/>
    <dbReference type="STRING" id="1460663.A0A177CMZ7"/>
    <dbReference type="GeneID" id="28767507"/>
    <dbReference type="InParanoid" id="A0A177CMZ7"/>
    <dbReference type="OrthoDB" id="1278353at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24351">
        <property type="entry name" value="RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="1"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAG08873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="456" mass="51825" checksum="B5831E1931CC6B0F" modified="2016-09-07" version="1" fragment="single">FIAPLSFTCQLPGKLQLYAPCISGGHLFHHLQRVGHFEEDAGRIYVAEIISGLEYLHDTLDTAFWLRSGDILLDLQGHVTLCNFGFFLRSDEDEETSARRLEYPPPESLIEENNSTQTVCRDKDGYKIANCWTLGVLLYEMLTGMPPFYSDDPETIRTRILDHYITLPESLSPSARELLVQLLEPKPKQRLGAGGVAETKAQAFFSSINWHKVLQRGYTPTLVPNDDTSCYKHYGVDYPYELPLSYYEAMRRQFAGWSYKGKKPQFEIPVEITSALSCSKASALTVSRNDDWQLVWDSTALEFRFHNRLTEEESLIPFRREDHRPSDGEEILSHANTTPSPNRYQMLAALEAAMINGYDCATLQLLDYTVDLNIAFGHKGLYCTPLQWAVMWDKSHLVQAFLDRSEASPDPRAATQALALAVEKQNIEIIDILLDADVQCNFRNADIPRTKGLMLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CN02</accession>
    <name>A0A177CN02_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phytase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_564324</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038645.1">
        <property type="nucleotide sequence ID" value="XM_018186713.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CN02"/>
    <dbReference type="STRING" id="1460663.A0A177CN02"/>
    <dbReference type="GeneID" id="28770199"/>
    <dbReference type="InParanoid" id="A0A177CN02"/>
    <dbReference type="OrthoDB" id="425936at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027372">
        <property type="entry name" value="Phytase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37957">
        <property type="entry name" value="BLR7070 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37957:SF1">
        <property type="entry name" value="PHYTASE-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13449">
        <property type="entry name" value="Phytase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008058401" description="Phytase-like domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="domain" description="Phytase-like" evidence="2">
        <location>
            <begin position="139"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG08280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="517" mass="55980" checksum="1EFB999E073F570E" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2024-11-27" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CPQ8</accession>
    <name>A0A177CPQ8_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_587280</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039134.1">
        <property type="nucleotide sequence ID" value="XM_018186790.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CPQ8"/>
    <dbReference type="GeneID" id="28770276"/>
    <dbReference type="InParanoid" id="A0A177CPQ8"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG08769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="96" mass="10386" checksum="230AD1919C7AD491" modified="2016-09-07" version="1">MAFTVPPRLQEIQSARHLNPDPSNVHHVFRRVPRLKEHLSVVASSTSGPVDIPSRIGGSGPPLLLLGGCPQTHRVWRRSAPALAEHFTVIAADICG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CPR6</accession>
    <name>A0A177CPR6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1050943</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039307.1">
        <property type="nucleotide sequence ID" value="XM_018173474.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CPR6"/>
    <dbReference type="STRING" id="1460663.A0A177CPR6"/>
    <dbReference type="GeneID" id="28756960"/>
    <dbReference type="InParanoid" id="A0A177CPR6"/>
    <dbReference type="OrthoDB" id="2586582at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000675">
        <property type="entry name" value="Cutinase/axe"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33630:SF9">
        <property type="entry name" value="CUTINASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33630">
        <property type="entry name" value="CUTINASE RV1984C-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01083">
        <property type="entry name" value="Cutinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01110">
        <property type="entry name" value="Cutinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG08942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="183" mass="18513" checksum="3537D783D65F5E8A" modified="2016-09-07" version="1" fragment="single">IISARGSTQAAGEGSLSSVSSLIKQALPGSVSVGLSYPATLDNYESSENTGVVNLKQAITSYTTSCPNSKIVLLGYSQGGQVVGDALGGASFSSEAPLASTYTKNIVAAVSFASPAHVAGKSYNAGTSKGSGIYKRANTATLDTYASRLDDICDSNDLFCDSGSSLTAHTQVVSKYASAGANF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CQ59</accession>
    <name>A0A177CQ59_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1240906</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG09088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039453.1">
        <property type="nucleotide sequence ID" value="XM_018184035.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CQ59"/>
    <dbReference type="GeneID" id="28767521"/>
    <dbReference type="InParanoid" id="A0A177CQ59"/>
    <dbReference type="OrthoDB" id="10003767at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="139"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG09088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="159" mass="17765" checksum="69726A4C9C6DC700" modified="2016-09-07" version="1" fragment="single">RIWNEDTPVLTILYQVTTLVYIQRYLCVKTPEVITHDQTRGNGLSQRYMLQTRLSGTPLVQLCPKLNLQQKKSIVHCITKFMLALYNREIPCAGIISPDNTIPISAAQGSIRYRSCALSLRRPRLTKSTPPPQPPRPRAPSSSRSASANANGRRKPGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CQH7</accession>
    <name>A0A177CQH7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_599896</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG09007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039372.1">
        <property type="nucleotide sequence ID" value="XM_018186832.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CQH7"/>
    <dbReference type="GeneID" id="28770318"/>
    <dbReference type="InParanoid" id="A0A177CQH7"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG09007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="151" mass="17230" checksum="2869608D86F5C375" modified="2016-09-07" version="1">MLLAQGVEKLLAWVSARQCDVFLMSEHFDFCCSLKYLENFWNEQSCKESLELAIMLKLCSAQTLPVLARCLCCVRHSELAVSFARVVKLRPDYLMTGVGGPPVVPYQQSAFSDAKQREDRKARQEHRSHRSPAQATILQPHQFLRHAILIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CQI0</accession>
    <name>A0A177CQI0_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1171814</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG09202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039567.1">
        <property type="nucleotide sequence ID" value="XM_018179933.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CQI0"/>
    <dbReference type="STRING" id="1460663.A0A177CQI0"/>
    <dbReference type="GeneID" id="28763419"/>
    <dbReference type="InParanoid" id="A0A177CQI0"/>
    <dbReference type="OrthoDB" id="5279008at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG09202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="488" mass="56459" checksum="74AF58E23CD862FB" modified="2016-09-07" version="1">MEQEEQVEQAVASVEPPSLLGVDFISKLPTEMIASICELLDKRSLHNFRMTSKHIHAQSYTSFFAHHFRVSSFTFTRDGLKKLVEFSKDPNIRPEIKVIRLILVAFPKQGKEHLSGLWHTPSEAMAAILAVEDGEYDVTGARIRQIRKYRKNIRRNRRRAYGRYQEDQNLLRRSGDDVNLLAEALRRLPALEEIDTVDIYGVDSPWGRGKIIEDLGEMPFTASMESWIPMKHDTYESRFEVERELKITSAHSVGAVLGAIRCSVIKFNGILELNGVPHSVRFAKWPHCSRLSLSATPARSFSLSMLADMKDTLSGLKALRVSTFSYVDRKYEDDPVEEYDIEWLYQLLERTTGLTSFSMNDNGARSNRTIDLDMMHSMEYRSITFPRLKAFMLLNAECETPVFIRFLEKHKTTLRRVCLDNINFRATTPLHTPDDRDTFLFVRWSERNYWRVIGYQSVSTELMDDYAQLEFRESLRSVICMNEALPVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CQJ0</accession>
    <name>A0A177CQJ0_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DNA-directed RNA polymerase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_1142208</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">DNA-dependent RNA polymerase which catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG09039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039404.1">
        <property type="nucleotide sequence ID" value="XM_018176353.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CQJ0"/>
    <dbReference type="FunCoup" id="A0A177CQJ0">
        <property type="interactions" value="1051"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CQJ0"/>
    <dbReference type="GeneID" id="28759839"/>
    <dbReference type="InParanoid" id="A0A177CQJ0"/>
    <dbReference type="OrthoDB" id="1162399at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990328">
        <property type="term" value="C:RPB4-RPB7 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003968">
        <property type="term" value="F:RNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003727">
        <property type="term" value="F:single-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000956">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060213">
        <property type="term" value="P:positive regulation of nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045948">
        <property type="term" value="P:positive regulation of translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010590">
        <property type="term" value="P:regulation of septum digestion after cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd04329">
        <property type="entry name" value="RNAP_II_Rpb7_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04462">
        <property type="entry name" value="S1_RNAPII_Rpb7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000043">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.120:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.120">
        <property type="entry name" value="RNA polymerase Rpb7-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036898">
        <property type="entry name" value="RNA_pol_Rpb7-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045113">
        <property type="entry name" value="Rpb7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005576">
        <property type="entry name" value="Rpb7-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709:SF4">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II, III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03876">
        <property type="entry name" value="SHS2_Rpb7-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88798">
        <property type="entry name" value="N-terminal, heterodimerisation domain of RBP7 (RpoE)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 8" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="S1 motif" evidence="7">
        <location>
            <begin position="81"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU369086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAG09039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="171" mass="19117" checksum="D28314B7C2A0AB1B" modified="2016-09-07" version="1">MFFIKELEKTITLHPSYFGPQIRLHLHRELLSKEEGSNTGSFTIVCILDSFDISDGQVVPGSGSAEYTVHYKAIVWRPYKGEVMDGIVTSVVRSGFFVSCGSLEAFVSRAMIPSEIKYDANATPPHWTDNADQVIEKGTNVRIKIKGVRSEVDRQFAIGTMKEDYLGPLQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CQN7</accession>
    <name>A0A177CQN7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">PQ loop repeat protein-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CC84DRAFT_1160889</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG09834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040199.1">
        <property type="nucleotide sequence ID" value="XM_018177606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CQN7"/>
    <dbReference type="GeneID" id="28761092"/>
    <dbReference type="InParanoid" id="A0A177CQN7"/>
    <dbReference type="OrthoDB" id="19344at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.290">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051415">
        <property type="entry name" value="LAAT-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006603">
        <property type="entry name" value="PQ-loop_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16201:SF11">
        <property type="entry name" value="PQ-LOOP REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16201">
        <property type="entry name" value="SEVEN TRANSMEMBRANE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04193">
        <property type="entry name" value="PQ-loop"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00679">
        <property type="entry name" value="CTNS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="18"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="50"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="92"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="140"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="170"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="208"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="233"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="266"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAG09834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="290" mass="31323" checksum="499F82986AAF9F01" modified="2016-09-07" version="1">MILSASSARCRELEHPDIANFSISVFILVGILVSYLPQHAKIIIRRSSRGLSPLFVLLGTVSGTASIANILTLPESTRDMACCSEIGRFPCAAALLGIAQIGVQWTCFFFIMLLFLIFFPRNAEDTESQDTNLPTWKEAIIVLAVSLAFFVFAFLGSIIFVYAAPSHIRGWANFLGLLATTLAAIQYIPQIITTWRLQETGSLSVPMMLIQTPGSFVFAASLAVRLGPGGWSAWGLFIFTGLLQGVLLGMSLWFIWRDRQAAKSGSSPAVDANGESDEQTPLIGNGIAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CQY1</accession>
    <name>A0A177CQY1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CC84DRAFT_1110672</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG09352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039717.1">
        <property type="nucleotide sequence ID" value="XM_018175260.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CQY1"/>
    <dbReference type="STRING" id="1460663.A0A177CQY1"/>
    <dbReference type="GeneID" id="28758746"/>
    <dbReference type="InParanoid" id="A0A177CQY1"/>
    <dbReference type="OrthoDB" id="1924787at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15485">
        <property type="entry name" value="ZIP_Cat8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.240.10:FF:000007">
        <property type="entry name" value="C6 transcription factor FacB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF12">
        <property type="entry name" value="REGULATORY PROTEIN CAT8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="23"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="100"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="648"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="104"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="121"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="674"/>
            <end position="685"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAG09352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="872" mass="96287" checksum="8860114352795A49" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CQZ2</accession>
    <name>A0A177CQZ2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CC84DRAFT_1202134</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG09378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039743.1">
        <property type="nucleotide sequence ID" value="XM_018181753.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CQZ2"/>
    <dbReference type="GeneID" id="28765239"/>
    <dbReference type="InParanoid" id="A0A177CQZ2"/>
    <dbReference type="OrthoDB" id="2130629at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718:SF11">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="132"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="169"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="200"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="236"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="266"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="307"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="342"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="370"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="395"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="435"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="470"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="37"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAG09378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="524" mass="57137" checksum="1433B8D498760B13" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CR36</accession>
    <name>A0A177CR36_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1202034</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG09237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039602.1">
        <property type="nucleotide sequence ID" value="XM_018181748.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CR36"/>
    <dbReference type="GeneID" id="28765234"/>
    <dbReference type="InParanoid" id="A0A177CR36"/>
    <dbReference type="OrthoDB" id="4734538at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG09237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="175" mass="19334" checksum="3CC95FC2572EEF79" modified="2016-09-07" version="1">MQDDHLQISHSDRSNSDPVRMQLLTNLMVTQPNSTKGNAQYDPITRKEDTLSTLALWMTVAPITVGINAEGTQPHYEYRADWIPAHHTSSARGANNQWTVPYIENFIRVPVGAAVLGDVVSWPSKRGDVSITSTVFQSKLDSKKPKLLAVPSAIILICAWVLIVCNLRLATLSEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CRD8</accession>
    <name>A0A177CRD8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_439135</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG09502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039867.1">
        <property type="nucleotide sequence ID" value="XM_018186274.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CRD8"/>
    <dbReference type="GeneID" id="28769760"/>
    <dbReference type="InParanoid" id="A0A177CRD8"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG09502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="235" mass="25354" checksum="C42C9DE48FA2FF08" modified="2016-09-07" version="1">MTYGSTYIKTPENACMLERHFQRPLLGLQQYVQRRHAAWPNHLRTKPRSDNPSLQSNHAPLHPSTHALPTTNGTSSPTHHPIPLNNTQPSALASSTIPLFSPAIPSSTLLSSTPSQPPSPLPPSSRYNLAIMPTNPTARNVSLAKHAQYTTRLVGPLMSAPAARNSGTANARVCVPRRRISSVGTRVCGGGERRARTADGETRKSVPESSLRVASVRSRVRMGDEGDRVGGGILR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CRS5</accession>
    <name>A0A177CRS5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Short chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CC84DRAFT_1183916</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG09642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040007.1">
        <property type="nucleotide sequence ID" value="XM_018180716.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CRS5"/>
    <dbReference type="STRING" id="1460663.A0A177CRS5"/>
    <dbReference type="GeneID" id="28764202"/>
    <dbReference type="InParanoid" id="A0A177CRS5"/>
    <dbReference type="OrthoDB" id="47007at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000374">
        <property type="entry name" value="3-oxoacyl-(Acyl-carrier-protein) reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48107">
        <property type="entry name" value="NADPH-DEPENDENT ALDEHYDE REDUCTASE-LIKE PROTEIN, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48107:SF7">
        <property type="entry name" value="RE15974P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAG09642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="284" mass="30204" checksum="A33246D3B5C07D69" modified="2016-09-07" version="1">MAPFRTFEGKLAIVTGASRSFGAVCAEHFASRGADVVIVYMTDDSTPRAQSLAKSFAEKYSIRALPVKADLSKPDAPQHVVDVAKAYFSDASGRFQIDIIINNAAIVNAQGIDQLDLDLFDATFNLNCKAPALLVKAAFPYLPTDRSGRIVNISSATTTWGVWWQTSYAGTKGALEAMTRVWARELAERCTVNAVAPGPMDTGLYSSLPDEPREALRPLNVLTPLAKARPGVDSPEVLELAQSIGGRPGYLEEVAGIVGIACLPESGWMTGNVLGANGGGAFVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CST5</accession>
    <name>A0A177CST5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Arginase/deacetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CC84DRAFT_1255871</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="6">Binds 2 manganese ions per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7 8">Belongs to the arginase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG09950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040315.1">
        <property type="nucleotide sequence ID" value="XM_018184580.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CST5"/>
    <dbReference type="STRING" id="1460663.A0A177CST5"/>
    <dbReference type="GeneID" id="28768066"/>
    <dbReference type="InParanoid" id="A0A177CST5"/>
    <dbReference type="OrthoDB" id="288726at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008783">
        <property type="term" value="F:agmatinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033389">
        <property type="term" value="P:putrescine biosynthetic process from arginine, via agmatine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008295">
        <property type="term" value="P:spermidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11592">
        <property type="entry name" value="Agmatinase_PAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.800.10:FF:000001">
        <property type="entry name" value="Agmatinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.10">
        <property type="entry name" value="Ureohydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006035">
        <property type="entry name" value="Ureohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020855">
        <property type="entry name" value="Ureohydrolase_Mn_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11358">
        <property type="entry name" value="ARGINASE/AGMATINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11358:SF28">
        <property type="entry name" value="HYPOTHETICAL ARGINASE FAMILY PROTEIN (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00491">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036979">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00116">
        <property type="entry name" value="ARGINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01053">
        <property type="entry name" value="ARGINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51409">
        <property type="entry name" value="ARGINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 6" id="KW-0464">Manganese</keyword>
    <keyword evidence="1 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0620">Polyamine biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0745">Spermidine biosynthesis</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008058633" evidence="9">
        <location>
            <begin position="18"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="298"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="300"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR036979-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAG09950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="376" mass="40020" checksum="BF9BB691997CEA16" modified="2016-09-07" version="1">MVSLHLVAMALLSSSAAREITFPPVSGFANQQVLGHGGEIDVTAGPAFAGLTTYANLPYVHCLAREGQQVDKFDIAILGAPFDTGVTARPGARFGPGGIRQGSRRIDPDAAWDIYTGKNVFYDFGSKIVDCGDAPLTFLDNTIALKQLDTSHRIISGRASNSSEYPIPRIVTLGGDHTTTLSALRSVASRWGTVSVIHFDSHIDTWDPRVLGGGVSHYAGVNHGTFLHIAHEEGLIRNTSIHAGIRAPVVRPRGDLRNDLRCGFEMVKARDIDRIGVSGVIEKLKKRVAGSKVYVSVDIDVLDPAFAPATGTAEVGGWTTRELLSILDGLAGLDIVGADVVEVAPIYDNPGETTVLAAAEVVQSLLRIMVAQPVKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CSU7</accession>
    <name>A0A177CSU7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF302 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1161509</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040970.1">
        <property type="nucleotide sequence ID" value="XM_018177758.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CSU7"/>
    <dbReference type="GeneID" id="28761244"/>
    <dbReference type="InParanoid" id="A0A177CSU7"/>
    <dbReference type="OrthoDB" id="5190258at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14797">
        <property type="entry name" value="DUF302"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.70">
        <property type="entry name" value="TT1751-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005180">
        <property type="entry name" value="DUF302"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035923">
        <property type="entry name" value="TT1751-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03625">
        <property type="entry name" value="DUF302"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103247">
        <property type="entry name" value="TT1751-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF302" evidence="1">
        <location>
            <begin position="93"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG10605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="182" mass="20396" checksum="9DE0C74F5C2BFF06" modified="2016-09-07" version="1">MAHHPTAKPQLACEYTATSTTITKLSCHFNDTYDTIIQKFRLQVPLLDISRMRAATKDKEISQAVEASGSPSGFVLFAEYNHAGWMRHFTIHGKPLQRAHRFTFGNPLFALPVLQHSIQAALHIPLDCCFIEELDRKRTKMIVTLPTTFLGSTEVDVDAARHALAEIEGKLLTLVQQLTPQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CT37</accession>
    <name>A0A177CT37_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1256468</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041058.1">
        <property type="nucleotide sequence ID" value="XM_018184627.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CT37"/>
    <dbReference type="STRING" id="1460663.A0A177CT37"/>
    <dbReference type="GeneID" id="28768113"/>
    <dbReference type="InParanoid" id="A0A177CT37"/>
    <dbReference type="OrthoDB" id="16820at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004493">
        <property type="term" value="F:methylmalonyl-CoA epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046491">
        <property type="term" value="P:L-methylmalonyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="entry name" value="2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051785">
        <property type="entry name" value="MMCE/EMCE_epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43048:SF6">
        <property type="entry name" value="BLR8189 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43048">
        <property type="entry name" value="METHYLMALONYL-COA EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="2">
        <location>
            <begin position="8"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG10693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="160" mass="17865" checksum="E0FFE503F80ADCC4" modified="2016-09-07" version="1">MPPLHNHVFNHVAISVPDCDKAIEWYGNVFGFRRLRGDRMTDRAEAQDAPIFKIYDSKLHKVKIAWLGTGNSVGFEVFEFIDPPNKPSPDFEYAKTGFFHIAVTSPDVDAAVARVLENGGDQVGETVIMGPEDKAAYVRDPWGNVVELLSCSFEHLMANK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CU10</accession>
    <name>A0A177CU10_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">DUF221-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CC84DRAFT_486326</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CSC1 (TC 1.A.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040863.1">
        <property type="nucleotide sequence ID" value="XM_018186469.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CU10"/>
    <dbReference type="GeneID" id="28769955"/>
    <dbReference type="InParanoid" id="A0A177CU10"/>
    <dbReference type="OrthoDB" id="2150324at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005227">
        <property type="term" value="F:calcium-activated cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045122">
        <property type="entry name" value="Csc1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003864">
        <property type="entry name" value="CSC1/OSCA1-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027815">
        <property type="entry name" value="CSC1/OSCA1-like_cyt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032880">
        <property type="entry name" value="CSC1/OSCA1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018:SF149">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G11660)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018">
        <property type="entry name" value="PROBABLE MEMBRANE PROTEIN DUF221-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14703">
        <property type="entry name" value="PHM7_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02714">
        <property type="entry name" value="RSN1_7TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13967">
        <property type="entry name" value="RSN1_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="121"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="167"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="390"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="440"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="482"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="597"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="655"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="686"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like N-terminal transmembrane" evidence="10">
        <location>
            <begin position="36"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like cytosolic" evidence="11">
        <location>
            <begin position="211"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like 7TM region" evidence="9">
        <location>
            <begin position="394"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="851"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="851"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="868"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="887"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="900"/>
            <end position="913"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF14703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OAG10498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="988" mass="112224" checksum="31690E505B57C248" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CUB6</accession>
    <name>A0A177CUB6_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CC84DRAFT_1161677</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041201.1">
        <property type="nucleotide sequence ID" value="XM_018177803.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CUB6"/>
    <dbReference type="STRING" id="1460663.A0A177CUB6"/>
    <dbReference type="GeneID" id="28761289"/>
    <dbReference type="InParanoid" id="A0A177CUB6"/>
    <dbReference type="OrthoDB" id="2117453at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008253">
        <property type="entry name" value="Marvel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37451">
        <property type="entry name" value="MARVEL DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37451:SF1">
        <property type="entry name" value="MARVEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01284">
        <property type="entry name" value="MARVEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="45"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="81"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="125"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="MARVEL" evidence="6">
        <location>
            <begin position="10"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAG10836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="163" mass="17752" checksum="90A3A41C2A4C8974" modified="2016-09-07" version="1">MVNFGKIILGARALQALLSVVVLGLMAYVASWWSSHWRAMSPVEVNFMVFSPVWSLLALAALVVVPMKFSSLAASSPGKFGLLALEILTMLYWFGGFIALALFLRDRICFGAVCDVAKAGTALSAVNWLVWMGSVVLSAVMVFKRETIAPMLKEPKVEMHQGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CUZ0</accession>
    <name>A0A177CUZ0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WD40 repeat-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CC84DRAFT_1161588</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041087.1">
        <property type="nucleotide sequence ID" value="XM_018177780.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CUZ0"/>
    <dbReference type="FunCoup" id="A0A177CUZ0">
        <property type="interactions" value="852"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CUZ0"/>
    <dbReference type="GeneID" id="28761266"/>
    <dbReference type="InParanoid" id="A0A177CUZ0"/>
    <dbReference type="OrthoDB" id="1284551at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000561">
        <property type="entry name" value="Putative WD repeat protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045159">
        <property type="entry name" value="DCAF7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19919">
        <property type="entry name" value="WD REPEAT CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="444"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="603"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="33"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="133"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="201"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="404"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="531"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="646"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="38"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="65"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="135"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="156"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="201"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="211"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="405"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="665"/>
            <end position="679"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAG10722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="725" mass="76345" checksum="F36726ABC9FAAFCC" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CVH8</accession>
    <name>A0A177CVH8_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">D-amino-acid oxidase</fullName>
            <ecNumber evidence="8">1.4.3.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CC84DRAFT_1192052</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a D-alpha-amino acid + O2 + H2O = a 2-oxocarboxylate + H2O2 + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:21816"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:35179"/>
            <dbReference type="ChEBI" id="CHEBI:59871"/>
            <dbReference type="EC" id="1.4.3.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:21817"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Peroxisome matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DAMOX/DASOX family.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.3" evidence="8"/>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG11533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041898.1">
        <property type="nucleotide sequence ID" value="XM_018181224.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CVH8"/>
    <dbReference type="STRING" id="1460663.A0A177CVH8"/>
    <dbReference type="GeneID" id="28764710"/>
    <dbReference type="InParanoid" id="A0A177CVH8"/>
    <dbReference type="OrthoDB" id="409956at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005782">
        <property type="term" value="C:peroxisomal matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003884">
        <property type="term" value="F:D-amino-acid oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019478">
        <property type="term" value="P:D-amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.9.10:FF:000018">
        <property type="entry name" value="D-amino acid oxidase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006181">
        <property type="entry name" value="D-amino_acid_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023209">
        <property type="entry name" value="DAO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11530">
        <property type="entry name" value="D-AMINO ACID OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11530:SF16">
        <property type="entry name" value="D-AMINO ACID OXIDASE (AFU_ORTHOLOGUE AFUA_5G11290)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000189">
        <property type="entry name" value="D-aa_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51971">
        <property type="entry name" value="Nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00677">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="11">
        <location>
            <begin position="6"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="243"/>
        </location>
        <ligand>
            <name>D-dopa</name>
            <dbReference type="ChEBI" id="CHEBI:149689"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="306"/>
        </location>
        <ligand>
            <name>D-dopa</name>
            <dbReference type="ChEBI" id="CHEBI:149689"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="333"/>
        </location>
        <ligand>
            <name>D-dopa</name>
            <dbReference type="ChEBI" id="CHEBI:149689"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00039101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000189-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OAG11533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="360" mass="38847" checksum="EFDB48E84B0DC54E" modified="2016-09-07" version="1">MDKRNVCVIGAGVAGLTTAYLLSQNRRYRIVVAAKHMPGDYDIEYASPWAGANYMPVSLRGTREEQWDRDTWAPLADLAQNHPDAGVHFQECEIHSRAKDIGSATADWFAELLSPNPWFKDVVPNFRVLPKESLPPGIDSATAFTSVCINTAIYLPWLVSQCLKNGVIFKRAVFKHIREAAQFAPSGKVDIVINCTGLGASVLGGVEDTTVVPARAQIVLVRNDAGKMMDFSGTDDGEGEACYIMTRAAGGGTILGGCYQKGNWESQVDPNLAVRIMKRAVASCPTLTGGKGIEHLDIIRHGVGLRPVREGGTRVEKERIEGLWVVHNYGAGGAGYQSSYGCASNAVQLVEETLAPASKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CVI6</accession>
    <name>A0A177CVI6_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Signal recognition particle subunit SRP14</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Signal recognition particle 14 kDa protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CC84DRAFT_1078518</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER).</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of a fungal signal recognition particle (SRP) complex that consists of a 7SL RNA molecule (scR1) and at least six protein subunits: SRP72, SRP68, SRP54, SEC65, SRP21 and SRP14.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the SRP14 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG11256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041621.1">
        <property type="nucleotide sequence ID" value="XM_018173803.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CVI6"/>
    <dbReference type="STRING" id="1460663.A0A177CVI6"/>
    <dbReference type="GeneID" id="28757289"/>
    <dbReference type="InParanoid" id="A0A177CVI6"/>
    <dbReference type="OrthoDB" id="19209at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005786">
        <property type="term" value="C:signal recognition particle, endoplasmic reticulum targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030942">
        <property type="term" value="F:endoplasmic reticulum signal peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.720.10">
        <property type="entry name" value="Signal recognition particle alu RNA binding heterodimer, srp9/1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003210">
        <property type="entry name" value="Signal_recog_particle_SRP14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009018">
        <property type="entry name" value="Signal_recog_particle_SRP9/14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12013">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 14 KD PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02290">
        <property type="entry name" value="SRP14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54762">
        <property type="entry name" value="Signal recognition particle alu RNA binding heterodimer, SRP9/14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 7" id="KW-0733">Signal recognition particle</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="39"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="120"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="39"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="51"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="123"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU368100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAG11256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="146" mass="16563" checksum="3808318766C8D2B0" modified="2016-09-07" version="1">MGREHLTNDEFFAQLNNLFEYNRNKGHGSVYLSQKRLTFDTESQPQTPTKVADDPLWDTHPKNPLPILVRAHNNKSSKLHGKSNGTDRKAIDKIVISTVVQPEKLDAFFVQYVEACKAGMSGLKKRDRRGKKDKKKKRKGAAETKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CVM3</accession>
    <name>A0A177CVM3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">WKF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_1159073</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG11573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041938.1">
        <property type="nucleotide sequence ID" value="XM_018177132.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CVM3"/>
    <dbReference type="GeneID" id="28760618"/>
    <dbReference type="InParanoid" id="A0A177CVM3"/>
    <dbReference type="OrthoDB" id="10261563at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019327">
        <property type="entry name" value="WKF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22306">
        <property type="entry name" value="CHROMOSOME 7 OPEN READING FRAME 50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22306:SF2">
        <property type="entry name" value="CHROMOSOME 7 OPEN READING FRAME 50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10180">
        <property type="entry name" value="WKF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WKF" evidence="3">
        <location>
            <begin position="306"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="22"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="396"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="443"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="359"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="28"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="101"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="130"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="145"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="185"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="443"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="481"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="499"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAG11573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="532" mass="58309" checksum="793E3C4D384F44AF" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CVU6</accession>
    <name>A0A177CVU6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1158888</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG11341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041706.1">
        <property type="nucleotide sequence ID" value="XM_018177093.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CVU6"/>
    <dbReference type="STRING" id="1460663.A0A177CVU6"/>
    <dbReference type="GeneID" id="28760579"/>
    <dbReference type="InParanoid" id="A0A177CVU6"/>
    <dbReference type="OrthoDB" id="2153847at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008058658" evidence="2">
        <location>
            <begin position="17"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="227"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="280"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="233"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG11341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="438" mass="42600" checksum="61F63BDF84410625" modified="2016-09-07" version="1">MKQSIIALSLVGAVLARPGVNRYSFEKREVPQEHAHRNVNLEVTKSLNLNNPDKIQDPVFGLLGAKAAAEGAGSIADPDCLQQATADQAFTNAKAAGDVNGMTFALIYRALERNTGSVGLASVPCTSIKAVNPEIAALQQHQDPASNGAAALNKQIATELAAQISAIGGDPTLANEASTFAPGQIGDPTAKGNTCDDDADDAGCINTLGLRVNDLTEAEALAAAQGGAGSAAGNGTANAGSGKAGSGKANQSKGNANNNANNNANNAACGAGAAAGAGAANGTASAGGNASNNSGNNAKSGNNAKSGNNAKSGNNAAAGAAAGAAAGAAAGAATGAATGAATGAASFGSCTDPTITFSQTPSDGRQEAAFEATDLTNFPHGSALGIGVISSFICDQLVNKCKADQAAVDKCDQADAAVKSSGLKGQAAADSFNKALGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CVU8</accession>
    <name>A0A177CVU8_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 10">Isocitrate lyase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CC84DRAFT_1133667</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate = pyruvate + succinate</text>
            <dbReference type="Rhea" id="RHEA:16809"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:57429"/>
            <dbReference type="EC" id="4.1.3.30"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>D-threo-isocitrate = glyoxylate + succinate</text>
            <dbReference type="Rhea" id="RHEA:13245"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
            <dbReference type="EC" id="4.1.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="13">Can also use Mn(2+) ion.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate metabolism; glyoxylate cycle; (S)-malate from isocitrate: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the isocitrate lyase/PEP mutase superfamily. Isocitrate lyase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG11694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042059.1">
        <property type="nucleotide sequence ID" value="XM_018175988.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CVU8"/>
    <dbReference type="FunCoup" id="A0A177CVU8">
        <property type="interactions" value="162"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CVU8"/>
    <dbReference type="GeneID" id="28759474"/>
    <dbReference type="InParanoid" id="A0A177CVU8"/>
    <dbReference type="OrthoDB" id="4078635at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004451">
        <property type="term" value="F:isocitrate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046421">
        <property type="term" value="F:methylisocitrate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006097">
        <property type="term" value="P:glyoxylate cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.850:FF:000001">
        <property type="entry name" value="Isocitrate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006254">
        <property type="entry name" value="Isocitrate_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018523">
        <property type="entry name" value="Isocitrate_lyase_ph_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01346">
        <property type="entry name" value="isocit_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21631:SF3">
        <property type="entry name" value="BIFUNCTIONAL GLYOXYLATE CYCLE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21631">
        <property type="entry name" value="ISOCITRATE LYASE/MALATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00463">
        <property type="entry name" value="ICL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001362">
        <property type="entry name" value="Isocit_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00161">
        <property type="entry name" value="ISOCITRATE_LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0329">Glyoxylate bypass</keyword>
    <keyword evidence="8 10 14" id="KW-0456">Lyase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="206"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="97"/>
            <end position="99"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="207"/>
            <end position="208"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="243"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="423"/>
            <end position="427"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="457"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR001362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR001362-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR001362-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001362-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OAG11694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="537" mass="59699" checksum="3DCB30BE04E35A64" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CWJ7</accession>
    <name>A0A177CWJ7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Diphthine methyl ester synthase</fullName>
            <ecNumber evidence="4">2.1.1.314</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Diphthamide biosynthesis methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CC84DRAFT_1132844</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">S-adenosyl-L-methionine-dependent methyltransferase that catalyzes four methylations of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine methyl ester. The four successive methylation reactions represent the second step of diphthamide biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + 4 S-adenosyl-L-methionine = diphthine methyl ester-[translation elongation factor 2] + 4 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:42652"/>
            <dbReference type="Rhea" id="RHEA-COMP:9749"/>
            <dbReference type="Rhea" id="RHEA-COMP:10173"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73995"/>
            <dbReference type="ChEBI" id="CHEBI:79005"/>
            <dbReference type="EC" id="2.1.1.314"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the diphthine synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.314" evidence="4"/>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG11240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041605.1">
        <property type="nucleotide sequence ID" value="XM_018175950.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CWJ7"/>
    <dbReference type="FunCoup" id="A0A177CWJ7">
        <property type="interactions" value="943"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CWJ7"/>
    <dbReference type="GeneID" id="28759436"/>
    <dbReference type="InParanoid" id="A0A177CWJ7"/>
    <dbReference type="OrthoDB" id="2516at2759"/>
    <dbReference type="UniPathway" id="UPA00559"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141133">
        <property type="term" value="F:diphthine methyl ester synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd11647">
        <property type="entry name" value="DHP5_DphB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.950.10:FF:000004">
        <property type="entry name" value="Diphthine synthase putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1010.10:FF:000004">
        <property type="entry name" value="Putative diphthine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="entry name" value="Cobalt-precorrin-4 Transmethylase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="entry name" value="Methyltransferase, Cobalt-precorrin-4 Transmethylase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01084">
        <property type="entry name" value="Diphthine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004551">
        <property type="entry name" value="Dphthn_synthase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00522">
        <property type="entry name" value="dph5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10882:SF0">
        <property type="entry name" value="DIPHTHINE METHYL ESTER SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10882">
        <property type="entry name" value="DIPHTHINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036432">
        <property type="entry name" value="Diphthine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="Tetrapyrrole methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Tetrapyrrole methylase" evidence="12">
        <location>
            <begin position="1"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="112"/>
            <end position="113"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="222"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="247"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00072033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00081951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR036432-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OAG11240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="286" mass="32007" checksum="A7F8168E25C18E94" modified="2016-09-07" version="1">MLYLVGLGLADERDITVKGLEIVKKAARVYLEAYTAVLLVDKDVLEAFYGRQVIVADREMVESSSDDILRDADKVDVAFLVVGDPFGATTHTDLVLRARELSIPTRSIPNASILTSIGTTGLQLYNFGQTVSMVFFLDNWKPASFYDRIRENVSVGLHTLVLLDIKVKEQSLENMARGRKIYEPPRYMTVAQCAQQMLEIEEDVKKEGVYSRESLAVGVARVGAEDEKIVAGTLGELCDADLGRPLHSLVLLGRRTHDLERDFLVEFAVDKETFARVWKSDYEGKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CX31</accession>
    <name>A0A177CX31_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1170362</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG11462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041827.1">
        <property type="nucleotide sequence ID" value="XM_018179854.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CX31"/>
    <dbReference type="STRING" id="1460663.A0A177CX31"/>
    <dbReference type="GeneID" id="28763340"/>
    <dbReference type="InParanoid" id="A0A177CX31"/>
    <dbReference type="OrthoDB" id="3251507at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027796">
        <property type="entry name" value="OTT_1508_deam-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42037">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42037:SF1">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14441">
        <property type="entry name" value="OTT_1508_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="471"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="471"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG11462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="519" mass="59031" checksum="079BFCD5D96020BE" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CXB4</accession>
    <name>A0A177CXB4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Defect at low temperature protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">DLT1</name>
        <name evidence="9" type="ORF">CC84DRAFT_1211479</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 7">Required for growth under high-pressure and low-temperature conditions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the DLT1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG11846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042211.1">
        <property type="nucleotide sequence ID" value="XM_018182383.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CXB4"/>
    <dbReference type="STRING" id="1460663.A0A177CXB4"/>
    <dbReference type="GeneID" id="28765869"/>
    <dbReference type="InParanoid" id="A0A177CXB4"/>
    <dbReference type="OrthoDB" id="4096362at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038869">
        <property type="entry name" value="DLT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40021">
        <property type="entry name" value="DEFECT AT LOW TEMPERATURE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40021:SF1">
        <property type="entry name" value="DEFECT AT LOW TEMPERATURE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="9"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="115"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="311"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="337"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="395"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAG11846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="437" mass="48261" checksum="DD4A26491B4446F3" modified="2016-09-07" version="1">MRIPTLFRIWYSTTYTVIFGILLVLLAVTPAETVYQSFRSDELQKIFVIGGVYVLTVLIILLVYSTRLYTNRSVLQAIPKPYVPIEDGEVGKLVRRMIVKKLRRSAVVAWDSMPRDARGEAGDDDGQGPTRAHHTHKKRHAFPATVIPVNPESPPWGRVSHPGWASPASPDLPNLQYSNVVNELPNLIEAKAVSLAPPDPALEDRALRIQDTPMLPDAQIVALLQRPRTMGLRDYLARLSSFGLLNPPTLGPKFLSLYEYARFSTKCLTEHEFRDIMAVFTEILNGMTELDPVVIDEARAASSDIETRSLAPTVSSYTSSHDSSRTGLPYRTPMADNRSEFSSEEHPSPSSPQTVQTAPSMIRTASGEGFVQPRTPSIRSAVSGEGSVRRSTMQRSPSTLLPNSSTSSLRSAGSVVVRLNLRPGVGDLPYQYRHEDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CXG9</accession>
    <name>A0A177CXG9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Glucose-6-phosphate 1-epimerase</fullName>
            <ecNumber evidence="3 5">5.1.3.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_1159608</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the interconversion between the alpha and beta anomers from at least three hexose 6-phosphate sugars (Glc6P, Gal6P, and Man6P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>alpha-D-glucose 6-phosphate = beta-D-glucose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:16249"/>
            <dbReference type="ChEBI" id="CHEBI:58225"/>
            <dbReference type="ChEBI" id="CHEBI:58247"/>
            <dbReference type="EC" id="5.1.3.15"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the glucose-6-phosphate 1-epimerase family.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.15" evidence="3 5"/>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042629.1">
        <property type="nucleotide sequence ID" value="XM_018177281.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CXG9"/>
    <dbReference type="FunCoup" id="A0A177CXG9">
        <property type="interactions" value="272"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CXG9"/>
    <dbReference type="GeneID" id="28760767"/>
    <dbReference type="InParanoid" id="A0A177CXG9"/>
    <dbReference type="OrthoDB" id="1659429at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047938">
        <property type="term" value="F:glucose-6-phosphate 1-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09020">
        <property type="entry name" value="D-hex-6-P-epi_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008183">
        <property type="entry name" value="Aldose_1/G6P_1-epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025532">
        <property type="entry name" value="G6P_1-epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11122">
        <property type="entry name" value="APOSPORY-ASSOCIATED PROTEIN C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11122:SF13">
        <property type="entry name" value="GLUCOSE-6-PHOSPHATE 1-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01263">
        <property type="entry name" value="Aldose_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016020">
        <property type="entry name" value="PHexose_mutarotase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="6">
        <location>
            <position position="189"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="294"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR016020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR016020-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR016020-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAG12264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="320" mass="34713" checksum="E89429630DAC3C9C" modified="2016-09-07" version="1">MVDRTNRPSALKATDAAGPEAQIDIVGSGASSKVIATLPSGESVEVLLFGATVTSWKSNGGKTENLWLSEKAALDGSKAVRGGVPVVFPVFGPPPKSGHPTSSLPQHGFARTSRWEFLGKSAAEDALGSDSVKLDFGLYSSGLTDEARKAWPLDFGLVYSVTLSKDSLQTVINVRNEGEQSFEFQFLLHTYFKIQDISKVAVNGLLGVTYVDKVLNATEHKQSDNSIKITGEVDRVYASIPQDTTSIVEDGKPRFDVVRDNLQDTVVWNPWIEKAKSMGDFSPDDDYKHMVCVEVGAVQGWQKLDKGEVFEGGQTIRSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CXZ8</accession>
    <name>A0A177CXZ8_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Trehalase</fullName>
            <ecNumber evidence="6">3.2.1.28</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Alpha-trehalose glucohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CC84DRAFT_1159183</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>alpha,alpha-trehalose + H2O = alpha-D-glucose + beta-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:32675"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15903"/>
            <dbReference type="ChEBI" id="CHEBI:16551"/>
            <dbReference type="ChEBI" id="CHEBI:17925"/>
            <dbReference type="EC" id="3.2.1.28"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the glycosyl hydrolase 37 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.28" evidence="6"/>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG11720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042085.1">
        <property type="nucleotide sequence ID" value="XM_018177163.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CXZ8"/>
    <dbReference type="FunCoup" id="A0A177CXZ8">
        <property type="interactions" value="314"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CXZ8"/>
    <dbReference type="GeneID" id="28760649"/>
    <dbReference type="InParanoid" id="A0A177CXZ8"/>
    <dbReference type="OrthoDB" id="3542292at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005946">
        <property type="term" value="C:alpha,alpha-trehalose-phosphate synthase complex (UDP-forming)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004555">
        <property type="term" value="F:alpha,alpha-trehalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030437">
        <property type="term" value="P:ascospore formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005993">
        <property type="term" value="P:trehalose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.10:FF:000026">
        <property type="entry name" value="Trehalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001661">
        <property type="entry name" value="Glyco_hydro_37"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018232">
        <property type="entry name" value="Glyco_hydro_37_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011120">
        <property type="entry name" value="Trehalase_Ca-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23403:SF6">
        <property type="entry name" value="CYTOSOLIC NEUTRAL TREHALASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23403">
        <property type="entry name" value="TREHALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01204">
        <property type="entry name" value="Trehalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07492">
        <property type="entry name" value="Trehalase_Ca-bi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00744">
        <property type="entry name" value="GLHYDRLASE37"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00927">
        <property type="entry name" value="TREHALASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00928">
        <property type="entry name" value="TREHALASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Neutral trehalase Ca2+ binding" evidence="8">
        <location>
            <begin position="84"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAG11720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="730" mass="84057" checksum="C420FBBDED19E161" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CYV7</accession>
    <name>A0A177CYV7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1227319</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018043100.1">
        <property type="nucleotide sequence ID" value="XM_018183609.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CYV7"/>
    <dbReference type="GeneID" id="28767095"/>
    <dbReference type="InParanoid" id="A0A177CYV7"/>
    <dbReference type="OrthoDB" id="3799381at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008058772" evidence="2">
        <location>
            <begin position="19"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG12735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="362" mass="38234" checksum="676546A4B9862288" modified="2016-09-07" version="1">MCLLLIVCLLVFAKSSTAAQPRDLHGVNGKFDTRSLHREAPDSDPSANPGYTLNPEWSHDSQNHAPNSLDPISPFNDNGRSQMVDNFLPAPWMMNCPALALDCSRCPRDLRCSRTLLTTKTPPHNGQITPQPAGLGGYNTITGQQDSDTPTVAGQQPPPCPLQKCSNAGAPPCGPGAICRKDNCACLHGRKGHPFGPKGWMALRGWTWPEALNIFVNPGVPCETPCDTLFCGEVRGRGCDGPQSLQPGSLDSIVSEAIVAQENSTSVVPSFQSLGIETLISTLKSKLATSAPTPLGQIVSTSKVVPGRSYVSHVSAAIPQSTGERPMGAIPTRSATNDDFSLPMAPGGMGAIQKPGAPPLRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CYZ6</accession>
    <name>A0A177CYZ6_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CC84DRAFT_158508</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018043130.1">
        <property type="nucleotide sequence ID" value="XM_018185418.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CYZ6"/>
    <dbReference type="STRING" id="1460663.A0A177CYZ6"/>
    <dbReference type="GeneID" id="28768904"/>
    <dbReference type="InParanoid" id="A0A177CYZ6"/>
    <dbReference type="OrthoDB" id="103819at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF3">
        <property type="entry name" value="HALOTOLERANCE PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="6">
        <location>
            <begin position="101"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="390"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="401"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAG12765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="460" mass="52301" checksum="0BBB9AB0BD90200B" modified="2016-09-07" version="1">MCTAVRQSQFAISSVPPDVLDDFIASKPEQIRERAWLVMFYSIALSNLDGSESSACTARLRSNLWLAFNDVRFLLEPSFLNIHALVTMTLHAEKYLAPYACWALISKACTMLIALGIGTHAHIDSTTRKQRDALFWRLNSLDKALSLILSRSPIFQRDLMNAVPLPTMEELLSTRNRLDGMPILFEAHFDHQMNLLSRVQAEVWHCLPGQETQNVDKVRKDLESWYTEATKILEASALVEMPLLSTRGQLSVDLRLQILLLNYYYLDVLLMVASKDLRSQCVVPAQKLLDLLPHLGELLSYDTKETHTCMLWEWLHYPMMAFGTLWGQVLSKGVSSHEQSERILKKLHNVPKYLERLESRHIIIGGKLKGITERIIHHVSAIYDASSPTQQRVAAKDDTADSATNQSRTYPSSTIDPFDMPSTSTDATFNAPVEDLMPLPDDFFLDPSFDWFSWEDQVSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CZN9</accession>
    <name>A0A177CZN9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Myosin class II heavy chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_1081050</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018043339.1">
        <property type="nucleotide sequence ID" value="XM_018173916.1"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CZN9"/>
    <dbReference type="GeneID" id="28757402"/>
    <dbReference type="InParanoid" id="A0A177CZN9"/>
    <dbReference type="OrthoDB" id="1293114at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32083:SF0">
        <property type="entry name" value="CILIA AND FLAGELLA-ASSOCIATED PROTEIN 58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32083">
        <property type="entry name" value="CILIA AND FLAGELLA-ASSOCIATED PROTEIN 58-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="227"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="287"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="720"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="881"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1019"/>
            <end position="1181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1198"/>
            <end position="1245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1284"/>
            <end position="1356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1431"/>
            <end position="1470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="2317"/>
            <end position="2447"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="1701"/>
            <end position="1805"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="1869"/>
            <end position="1896"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="1922"/>
            <end position="2055"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="2122"/>
            <end position="2149"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="2186"/>
            <end position="2213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="38"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="56"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="227"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="249"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="296"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="339"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="791"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="813"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="892"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1024"/>
            <end position="1033"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="1034"/>
            <end position="1044"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1095"/>
            <end position="1108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1145"/>
            <end position="1159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1284"/>
            <end position="1295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="1449"/>
            <end position="1458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="2317"/>
            <end position="2327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="2328"/>
            <end position="2359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="2375"/>
            <end position="2384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAG12974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2447" mass="270813" checksum="5DF1E80E6A9D65AA" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177D208</accession>
    <name>A0A177D208_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CC84DRAFT_1212536</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family. Isoflavone reductase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG13079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018043444.1">
        <property type="nucleotide sequence ID" value="XM_018182462.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177D208"/>
    <dbReference type="STRING" id="1460663.A0A177D208"/>
    <dbReference type="GeneID" id="28765948"/>
    <dbReference type="InParanoid" id="A0A177D208"/>
    <dbReference type="OrthoDB" id="419598at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051609">
        <property type="entry name" value="NmrA/Isoflavone_reductase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706:SF7">
        <property type="entry name" value="CIPA-LIKE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G01630)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706">
        <property type="entry name" value="NMRA-LIKE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-binding" evidence="4">
        <location>
            <begin position="9"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAG13079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="145" mass="15742" checksum="26B0F0129577DC3E" modified="2016-09-07" version="1">MFIALRFIADGNVGRFITSALLKTGKHTITAITRTDSQSKLPDNVTIAKDDYSNHTSLVSALKCHDALVITPSGHAVARRKLIEELGQSSFVVVVTVLLIGRAVAALISLPIKSETEACLDKFRNKIVWVSSFTVNQEDMCASVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BUK1</accession>
    <name>A0A177BUK1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DUF636 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CC84DRAFT_1132473</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfa family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441565">
        <property type="protein sequence ID" value="OAF98650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029016.1">
        <property type="nucleotide sequence ID" value="XM_018175937.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BUK1"/>
    <dbReference type="GeneID" id="28759423"/>
    <dbReference type="InParanoid" id="A0A177BUK1"/>
    <dbReference type="OrthoDB" id="406544at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016846">
        <property type="term" value="F:carbon-sulfur lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1590.10">
        <property type="entry name" value="glutathione-dependent formaldehyde- activating enzyme (gfa)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006913">
        <property type="entry name" value="CENP-V/GFA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337:SF30">
        <property type="entry name" value="DUF636 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G03180)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337">
        <property type="entry name" value="GFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04828">
        <property type="entry name" value="GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51891">
        <property type="entry name" value="CENP_V_GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CENP-V/GFA" evidence="5">
        <location>
            <begin position="3"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAF98650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="137" mass="14637" checksum="346B5247A7C90869" modified="2016-09-07" version="1" fragment="single">MAQQGGCMCGNIRYSVEGEPVSKALCHCADCRKITGSTYSTNAIFPSKQFNLTRGTPKQHSKTADTGNKITSHFCGDCGSTLFRETSAFEGAKIVKIGTLDDANALSDLKPGVELFAKNRIPWVEAVAGAQQKDAMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BV03</accession>
    <name>A0A177BV03_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1169441</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441562">
        <property type="protein sequence ID" value="OAF99303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029669.1">
        <property type="nucleotide sequence ID" value="XM_018179662.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BV03"/>
    <dbReference type="GeneID" id="28763148"/>
    <dbReference type="InParanoid" id="A0A177BV03"/>
    <dbReference type="OrthoDB" id="5406607at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="263"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="293"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="478"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="504"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="546"/>
            <end position="566"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAF99303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="582" mass="64736" checksum="613842AE93E16273" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BVH3</accession>
    <name>A0A177BVH3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Nucleoside transporter-like protein family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CC84DRAFT_1223000</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441562">
        <property type="protein sequence ID" value="OAF99314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029680.1">
        <property type="nucleotide sequence ID" value="XM_018183452.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BVH3"/>
    <dbReference type="FunCoup" id="A0A177BVH3">
        <property type="interactions" value="269"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177BVH3"/>
    <dbReference type="GeneID" id="28766938"/>
    <dbReference type="InParanoid" id="A0A177BVH3"/>
    <dbReference type="OrthoDB" id="46396at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034257">
        <property type="term" value="F:nicotinamide riboside transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015205">
        <property type="term" value="F:nucleobase transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002259">
        <property type="entry name" value="Eqnu_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10332">
        <property type="entry name" value="EQUILIBRATIVE NUCLEOSIDE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10332:SF88">
        <property type="entry name" value="EQUILIBRATIVE NUCLEOSIDE TRANSPORTER 1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01733">
        <property type="entry name" value="Nucleoside_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016379">
        <property type="entry name" value="ENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01130">
        <property type="entry name" value="DERENTRNSPRT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="45"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="119"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="143"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="182"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="222"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="282"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="356"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="386"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="424"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="23"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAF99314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="449" mass="49214" checksum="4406085EB1CDC3A3" modified="2016-09-07" version="1">MGLIQRLLRREEPEQSYAPLEGGSERPDGERIEDLEQRAYSRTDYYVFLLLGVAMLWAWNMFLAAAPYFQRRFDSDERLLRNFQSAELAVSTAGSLGSMIVLTKLQANASYPKRITSSLILNIAVFTLLAISTRAFLDVSAGAYFAFLMLVVFSASLATALCQNGVFAYVASFGREEYTQGIMTGQGIAGVLPCIAQIVSVLSVPPKQTQEGAPQESSKSAFIYFLTATVISALTLVAFVYLLSKPRSREQLSPTLDDEEVDPGHRPVTRKSIPMMRLLGKLHWLAGAVFLTFAITMFYPVFTQKILSVRDPATSSRLFQPAVFIPLGFLFWNIGDLIGRVIPGIPGLTLTARPRLLFTLAVGRLAFIPVYLLCNIGGKGAVIGSDFFYLFILQVLFGISNGYIGSNCMMGFVEWVDPEEREAAGGFMSLCLVAGLTAGSFLSFFAASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BVP0</accession>
    <name>A0A177BVP0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">UPF0187-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CC84DRAFT_1233936</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441564">
        <property type="protein sequence ID" value="OAF98791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029157.1">
        <property type="nucleotide sequence ID" value="XM_018183796.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BVP0"/>
    <dbReference type="STRING" id="1460663.A0A177BVP0"/>
    <dbReference type="GeneID" id="28767282"/>
    <dbReference type="InParanoid" id="A0A177BVP0"/>
    <dbReference type="OrthoDB" id="1368at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044669">
        <property type="entry name" value="YneE/VCCN1/2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33281">
        <property type="entry name" value="UPF0187 PROTEIN YNEE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33281:SF19">
        <property type="entry name" value="VOLTAGE-DEPENDENT ANION CHANNEL-FORMING PROTEIN YNEE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25539">
        <property type="entry name" value="Bestrophin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="252"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="277"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAF98791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="397" mass="44622" checksum="6D903ED3FB83C70C" modified="2016-09-07" version="1">MAEKTTSAESSQTLPRQRHTGVPLKRTKSDDTDFDDYFQKVGINQLLLTVLGFVVGLALSFRSSTAYERYNEGRKYWAQLAFVSQHLARLIWVHAEERHTKDPVVGKKDLLGKISCLNMIVAFAMALKHKLRFEPYAHYEDLQHIVGHLDTYAKAADQPTPPRKQNIFKTAGQFLGLPFAESNPRKLLKKSNVPLGNLPLEILTHLSAYMKSIYDNETLKVSVYQTQSLAALQTMNDVLSGTDRILSTPLPIAYTIAISQITWVYILLLPFQLFKSLGWVTIPASVFAAYIILGIALIGREIENPFGSDVNDLPLDAFCGQIRADIDLIMSKPAPTVDEFLMNDANEMLYPLSNLGGRALAEQSVEEIREKLAQKPRVHYKHTESEEGEMVRNSDNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BVT3</accession>
    <name>A0A177BVT3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Transcription factor tfiiic complex a box associated subunit sfc1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_1169614</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441562">
        <property type="protein sequence ID" value="OAF99522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029888.1">
        <property type="nucleotide sequence ID" value="XM_018179701.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BVT3"/>
    <dbReference type="STRING" id="1460663.A0A177BVT3"/>
    <dbReference type="GeneID" id="28763187"/>
    <dbReference type="InParanoid" id="A0A177BVT3"/>
    <dbReference type="OrthoDB" id="5598268at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000127">
        <property type="term" value="C:transcription factor TFIIIC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001002">
        <property type="term" value="F:RNA polymerase III type 1 promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001003">
        <property type="term" value="F:RNA polymerase III type 2 promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006384">
        <property type="term" value="P:transcription initiation at RNA polymerase III promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.160">
        <property type="entry name" value="TFIIIC, subcomplex tauA, subunit Sfc1, barrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019136">
        <property type="entry name" value="TF_IIIC_su-5_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040454">
        <property type="entry name" value="TF_IIIC_Tfc1/Sfc1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041499">
        <property type="entry name" value="Tfc1/Sfc1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042536">
        <property type="entry name" value="TFIIIC_tauA_Sfc1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13230:SF5">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13230">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIIC, POLYPEPTIDE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09734">
        <property type="entry name" value="Tau95"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17682">
        <property type="entry name" value="Tau95_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="Transcription factor IIIC subunit Tfc1/Sfc1 triple barrel" evidence="7">
        <location>
            <begin position="23"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="Transcription factor IIIC subunit 5 HTH" evidence="6">
        <location>
            <begin position="219"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="532"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="543"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="567"/>
            <end position="623"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF09734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAF99522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="636" mass="72080" checksum="5EAABE4EF5C3CEE7" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BW03</accession>
    <name>A0A177BW03_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF3752 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1104851</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441563">
        <property type="protein sequence ID" value="OAF99120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029486.1">
        <property type="nucleotide sequence ID" value="XM_018175074.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BW03"/>
    <dbReference type="GeneID" id="28758560"/>
    <dbReference type="InParanoid" id="A0A177BW03"/>
    <dbReference type="OrthoDB" id="73491at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022226">
        <property type="entry name" value="DUF3752"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046331">
        <property type="entry name" value="GPAM1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46370">
        <property type="entry name" value="GPALPP MOTIFS-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46370:SF1">
        <property type="entry name" value="GPALPP MOTIFS-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12572">
        <property type="entry name" value="DUF3752"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3752" evidence="2">
        <location>
            <begin position="162"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAF99120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="313" mass="34041" checksum="4E603D6534ED560A" modified="2016-09-07" version="1">MPIGPSLPPHLAKRARDDDDENKGSTSPESGEKRRRILGPAPPPAQPSLPRTAGPSLPPQSRSRSSSEDSHVGPAPPPPPKPARVLGPAPPPAPLDERPPNPPSDDSDSSDDDFGPAPPPAGASYTSYDAPSSRPAKSAFDTDPQYSEENKKVQRDSWMTMPPTQDDLAARMDPTKMRARKFNTGKSAGAGGAGGMDIWTETPEQKLKRLQDEAMGISAHSNSLTSKKETRRNRDEEEKTMRMREKLEASRGKSLVEAHEAKTGKEKEDDPSKRAFDYEKDMALGGKVNHKQKREMLNKAKGFGDRFSSGSFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BW50</accession>
    <name>A0A177BW50_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial division protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CC84DRAFT_1075487</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in mitochondrial fission. Acts as an adapter protein required to form mitochondrial fission complexes. Formation of these complexes is required to promote constriction and fission of the mitochondrial compartment at a late step in mitochondrial division.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat MDV1/CAF4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441566">
        <property type="protein sequence ID" value="OAF98596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018028962.1">
        <property type="nucleotide sequence ID" value="XM_018173712.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BW50"/>
    <dbReference type="STRING" id="1460663.A0A177BW50"/>
    <dbReference type="GeneID" id="28757198"/>
    <dbReference type="InParanoid" id="A0A177BW50"/>
    <dbReference type="OrthoDB" id="538223at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990234">
        <property type="term" value="C:transferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847:SF637">
        <property type="entry name" value="WD REPEAT DOMAIN 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="69"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00039789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00043913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAF98596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="112" mass="12369" checksum="7EE67FCCA4378204" modified="2016-09-07" version="1" fragment="single">LSPLVQDAQRFIMYHKGVIEGHPLQTYASALLFSPTGSLIRRIFQHEEPKQITIKPALSDNWSACLQILEGHSSSVNSVVFSPDLARLASVSYNRTVKIWDASSGACLQTLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BWJ4</accession>
    <name>A0A177BWJ4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_1200307</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441563">
        <property type="protein sequence ID" value="OAF99121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029487.1">
        <property type="nucleotide sequence ID" value="XM_018181657.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A177BWJ4">
        <property type="interactions" value="89"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177BWJ4"/>
    <dbReference type="GeneID" id="28765143"/>
    <dbReference type="InParanoid" id="A0A177BWJ4"/>
    <dbReference type="OrthoDB" id="289913at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030897">
        <property type="term" value="C:HOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034058">
        <property type="term" value="P:endosomal vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059070">
        <property type="entry name" value="TPR_VPS8_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045111">
        <property type="entry name" value="Vps41/Vps8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025941">
        <property type="entry name" value="Vps8_central_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12616">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING VPS41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12616:SF8">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 8 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23410">
        <property type="entry name" value="Beta-prop_VPS8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12816">
        <property type="entry name" value="TPR_Vps8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25066">
        <property type="entry name" value="TPR_VPS8_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Vacuolar protein sorting-associated protein 8 central" evidence="2">
        <location>
            <begin position="707"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="domain" description="VPS8-like TPR-like repeats" evidence="3">
        <location>
            <begin position="1173"/>
            <end position="1364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1272"/>
            <end position="1299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="22"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1272"/>
            <end position="1285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAF99121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="1485" mass="164186" checksum="91929B16485C0F39" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BWP3</accession>
    <name>A0A177BWP3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_1169324</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441562">
        <property type="protein sequence ID" value="OAF99171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029537.1">
        <property type="nucleotide sequence ID" value="XM_018179640.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BWP3"/>
    <dbReference type="STRING" id="1460663.A0A177BWP3"/>
    <dbReference type="GeneID" id="28763126"/>
    <dbReference type="InParanoid" id="A0A177BWP3"/>
    <dbReference type="OrthoDB" id="5130013at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF39">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="10"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAF99171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="500" mass="57335" checksum="5B3708CC15425C0C" modified="2016-09-07" version="1">MGRAATGKRSCGTCKDRKILCDRTTPTCSQCTRTKRECKGYGLRLSWPREKDARRAIVLQSSRHNIKHSDKRVKNASMVHATNWDIEMYMFLSALAARAPVLHEPVRWNPHQMGEVEWDLLNYFQLEASRSLTTFGSDPKHLAKFLMQISQNGKSPASKAVLHSILGLSSVYRYGWNAQAMEFKISSLRALAQASETFEESVEGTHHVAAGMLLCSLEVHMASCSASEWTWYVNGIKEILYSDIPHRKCTLDVEKTMLMNWVYYHDIMKVFSIRHWKPEREDEVIASISQPQILNESSTRKLVSREELTYCDEPLSSAPWIPAILKLMSELCDTVPTKPCLQSMSAQELDVYANRIKILDWRIRDIPMPSPTEKSSASVYLYQLAMLIYLNRVTENILKQTSKLKGYIDNAFTLISELETCKPHFPMYIIGWEARTDEQRATFLEMLERTKKDPSSRSVFHVEALVQAGWTQDDLAEEDLNYWDKVTTLVSVCFTMPSFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BWZ0</accession>
    <name>A0A177BWZ0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Mitochondrial carrier</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CC84DRAFT_1169635</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Transport of phosphate groups from the cytosol to the mitochondrial matrix.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441563">
        <property type="protein sequence ID" value="OAF98886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029252.1">
        <property type="nucleotide sequence ID" value="XM_018179708.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BWZ0"/>
    <dbReference type="FunCoup" id="A0A177BWZ0">
        <property type="interactions" value="796"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177BWZ0"/>
    <dbReference type="GeneID" id="28763194"/>
    <dbReference type="InParanoid" id="A0A177BWZ0"/>
    <dbReference type="OrthoDB" id="427452at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035434">
        <property type="term" value="P:copper ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990547">
        <property type="term" value="P:mitochondrial phosphate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000076">
        <property type="entry name" value="Mitochondrial phosphate carrier protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000131">
        <property type="entry name" value="Mitochondrial phosphate carrier protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044677">
        <property type="entry name" value="SLC25A3/Pic2/Mir1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45671">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25 (MITOCHONDRIAL CARRIER PHOSPHATE CARRIER), MEMBER 3, LIKE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45671:SF10">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25 MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 11 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="87"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="184"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="285"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00054508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OAF98886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="386" mass="41790" checksum="DE57B6F136AA5C32" modified="2016-09-07" version="1">MPTLFPAPSTLSQVFSGCSVIAHSVPESPSKRAAKWNARHELYTAWSAADDARNKAAKLSDAAVAEFEKASSKAQAKVGGIELYSAKFYAACTVGGIMACGLTHTAVTPLDLVKCRRQVDSKMYKGNFEAWSKIGRAEGLRGVFTGWSPTFWGYSVQGGLKYGGYEFFKKYYADLAGEENFHKYKTLIYLAGSASAEFIADIGLCPFEAVKVRMQTTIPPFATGTLNGINTIVGKEGVAGLYKGLYPLWGRQIPYTMMKFASFETVVEMIYHRLPGQKSDYGKGAQTAVSFTGGYIAGILCAIVSHPADVMVSKLNATRQAGESFGAATGRIYKDIGFGGLWNGLPVRIVMIGTLTGLQWMIYDYFKIFMGLPTTGGAPPEEKKNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BXD9</accession>
    <name>A0A177BXD9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Fanconi-associated nuclease</fullName>
            <ecNumber evidence="5">3.1.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_1131892</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Nuclease required for the repair of DNA interstrand cross-links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>Hydrolytically removes 5'-nucleotides successively from the 3'-hydroxy termini of 3'-hydroxy-terminated oligonucleotides.</text>
            <dbReference type="EC" id="3.1.4.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="5">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the FAN1 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.1" evidence="5"/>
    <dbReference type="EMBL" id="KV441563">
        <property type="protein sequence ID" value="OAF99056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029422.1">
        <property type="nucleotide sequence ID" value="XM_018175916.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BXD9"/>
    <dbReference type="STRING" id="1460663.A0A177BXD9"/>
    <dbReference type="GeneID" id="28759402"/>
    <dbReference type="InParanoid" id="A0A177BXD9"/>
    <dbReference type="OrthoDB" id="76364at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008409">
        <property type="term" value="F:5'-3' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070336">
        <property type="term" value="F:flap-structured DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004528">
        <property type="term" value="F:phosphodiesterase I activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22326">
        <property type="entry name" value="FAN1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1350.10:FF:000009">
        <property type="entry name" value="Fanconi-associated nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033315">
        <property type="entry name" value="Fan1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049132">
        <property type="entry name" value="FAN1-like_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049126">
        <property type="entry name" value="FAN1-like_TPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049125">
        <property type="entry name" value="FAN1-like_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014883">
        <property type="entry name" value="VRR_NUC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15749">
        <property type="entry name" value="FANCONI-ASSOCIATED NUCLEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15749:SF4">
        <property type="entry name" value="FANCONI-ASSOCIATED NUCLEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21315">
        <property type="entry name" value="FAN1_HTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21170">
        <property type="entry name" value="FAN1_TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08774">
        <property type="entry name" value="VRR_NUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00990">
        <property type="entry name" value="VRR_NUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VRR-NUC" evidence="7">
        <location>
            <begin position="728"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="301"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="63"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="318"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU365033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAF99056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="857" mass="97744" checksum="D0917C64D4103F59" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2023-06-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BYI2</accession>
    <name>A0A177BYI2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1230750</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441559">
        <property type="protein sequence ID" value="OAG00584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030949.1">
        <property type="nucleotide sequence ID" value="XM_018183702.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BYI2"/>
    <dbReference type="GeneID" id="28767188"/>
    <dbReference type="InParanoid" id="A0A177BYI2"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG00584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="290" mass="31675" checksum="EDBF60E4065E0778" modified="2016-09-07" version="1">MSKFVNTRISVRGGLTACILAFPVQASIVHNENEKILNDDCIKQGILQYAKRNTKPETSKCSIKRIADATLEASKPCPHVNKTNIKAVHISGSRFWSSIIGDLSKRLEASLQALLRHLRLRTQATLVPIARRSNVGTMPRVLPPTTTTATAVTLDRTEVRRRIFRHILRGLASPKVRRATAGADNAAGYAPFLLEPVRMELVGNGLVAERVCREIGTVEGVVTTATCQLAERMVALLKFQSVSMPATTAPPGSVGAIMHTDSTKLRLIDRENLAAPADVVTGLWGYQWHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2023-06-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BYQ9</accession>
    <name>A0A177BYQ9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1222831</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441561">
        <property type="protein sequence ID" value="OAF99828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030194.1">
        <property type="nucleotide sequence ID" value="XM_018183423.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BYQ9"/>
    <dbReference type="GeneID" id="28766909"/>
    <dbReference type="InParanoid" id="A0A177BYQ9"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008057551" evidence="1">
        <location>
            <begin position="19"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAF99828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="104" mass="10992" checksum="5C8A6411D2F9E1A1" modified="2016-09-07" version="1">MNLITCFAAVFAEFAAYADPPVAPGSDLSGGPTFGKAPRDYVTNKTRSAAADLATHSHTTDVKDSLVEGAHQDIYTAGVVARTTDDGDAVLALEKPKRPWDSLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BZL3</accession>
    <name>A0A177BZL3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1169288</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441561">
        <property type="protein sequence ID" value="OAF99789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030155.1">
        <property type="nucleotide sequence ID" value="XM_018179625.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BZL3"/>
    <dbReference type="STRING" id="1460663.A0A177BZL3"/>
    <dbReference type="GeneID" id="28763111"/>
    <dbReference type="InParanoid" id="A0A177BZL3"/>
    <dbReference type="OrthoDB" id="5371583at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42069">
        <property type="entry name" value="HYPHAL ANASTAMOSIS-8 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42069:SF1">
        <property type="entry name" value="MARVEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="144"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="176"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="244"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="18"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAF99789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="291" mass="32873" checksum="55C6593F20960AEC" modified="2016-09-07" version="1">MASSAYYEAHPLSVDQQQQQHLLSPPLGSPEHIHSGRSSEQSSPLKPLHVATSMDSIAKRQSLVDFEGLRKAHEEDTALKARIRRLRVVSRVLGLLISVAVFIPIALTLHKFLSTQNVYRDVTRDGVTKHRTAWAKDSKVWPTWMYFLIAAISVVLNIVIIFAYKFGIDKANKAATVATTFNWFVMLGNLAVWCVAASLYRTEKDKDGKSNDLWGWTCSPLAREIQKEFAHEVDFDKFCNVQSISWYIGLVQVGAAVLTVVTYVFVMARRSKKKSLKKRHSQMAGQYPTNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C0D7</accession>
    <name>A0A177C0D7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Integral membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1101681</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441558">
        <property type="protein sequence ID" value="OAG01103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031468.1">
        <property type="nucleotide sequence ID" value="XM_018174927.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C0D7"/>
    <dbReference type="GeneID" id="28758413"/>
    <dbReference type="InParanoid" id="A0A177C0D7"/>
    <dbReference type="OrthoDB" id="5420247at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42029">
        <property type="entry name" value="AN04G07800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42029:SF3">
        <property type="entry name" value="AN04G07800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="22"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="184"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG01103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="297" mass="33765" checksum="73673E1AD0C21F48" modified="2016-09-07" version="1">MGAARDKCAHTVDGVSGTIAEAWGQGYMVGGLVVLMLLTLASFRRHVLLHKLILAELILATFRGTYIFFSGPNAGWYSSCTSVLLYISYNLHNVINWIKIKPFLSRTGHWVYLSTLILVWPYWIVECYFLFQYNNNLGSDYFVHLRPWEFLCREPWWLFTTGYLIYIIKRAYDCSIVHLIRTSGKFLVLLSSMALSIGFIIADVVIVLVIDTPCRGKNPLWKIAFIFKCTADVIVLDDFKSVLDRISVRGSTSSGDSLGVKEDRDIPQHIEAVCPRDTGSRRQGIASMDWFDDIQVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C1I9</accession>
    <name>A0A177C1I9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CC84DRAFT_1198592</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441557">
        <property type="protein sequence ID" value="OAG01296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031661.1">
        <property type="nucleotide sequence ID" value="XM_018181577.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C1I9"/>
    <dbReference type="STRING" id="1460663.A0A177C1I9"/>
    <dbReference type="GeneID" id="28765063"/>
    <dbReference type="InParanoid" id="A0A177C1I9"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016712">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002974">
        <property type="entry name" value="Cyt_P450_E_CYP52_ascomycetes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047146">
        <property type="entry name" value="Cyt_P450_E_CYP52_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24287:SF18">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE APDE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24287">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01239">
        <property type="entry name" value="EP450IICYP52"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAG01296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="395" mass="44214" checksum="F6EF2815377CF424" modified="2016-09-07" version="1">MSDINSILHAFRAAREQKLLRVMREIVQTTGPTFEQRLLGFRGIDTVDPINVEAVLSTHFSDFGLGERRLVFAPLLGQGIFTQDGKPWAHSRALLKPAFSRQDQSMAQIAEVTDQLLNLIPVSGSFIDDENTFAIAFDKGQDYLAQSGRLGGLHWLIDSSDFRIQCKRVHEHVDNAIMQVLQEQDTGDKQSTQSILQDLVQQSTEKKVLREQCLNVLLAGRDTTACLLSWTFRLLAKHSAVFNRCREDILNSCGFSGQITRQKIKYHMDDLPLKVLRLYPSVPINSRTATHTTTLPTGGGPNGTAPILVRKGEAVGYCPYIMHRRQETFGPDAEAFRPERWLENGSQAGYVVARMLQKFSSLRLPKEEPMEAIGTEKQKLTLVMCSAIGCNVVLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C1V2</accession>
    <name>A0A177C1V2_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Kazal-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1180603</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441559">
        <property type="protein sequence ID" value="OAG00610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030975.1">
        <property type="nucleotide sequence ID" value="XM_018180489.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C1V2"/>
    <dbReference type="STRING" id="1460663.A0A177C1V2"/>
    <dbReference type="GeneID" id="28763975"/>
    <dbReference type="InParanoid" id="A0A177C1V2"/>
    <dbReference type="OrthoDB" id="3752755at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008057590" description="Kazal-like domain-containing protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG00610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="184" mass="19719" checksum="EA7C887E6EDF5B03" modified="2016-09-07" version="1">MKAIYLLICMFAVTVIGTPAKRDCPQQQCVNITDSCGEPVRECWDDCALGLSERPTFVVPSCSVSTPILLATALGTAPARAAFIPPDMTSAPYPIATSPTEGCKSEKTICIDYLKECANGTYSIPYGGCHDACSIHKVYLAPSCSKTWIAGPTTTKTKTKKPSVTRPACKNAKSFMCAPLNWLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C306</accession>
    <name>A0A177C306_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">mannan endo-1,6-alpha-mannosidase</fullName>
            <ecNumber evidence="3">3.2.1.101</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_1044589</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>Random hydrolysis of (1-&gt;6)-alpha-D-mannosidic linkages in unbranched (1-&gt;6)-mannans.</text>
            <dbReference type="EC" id="3.2.1.101"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 76 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.101" evidence="3"/>
    <dbReference type="EMBL" id="KV441556">
        <property type="protein sequence ID" value="OAG02003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032368.1">
        <property type="nucleotide sequence ID" value="XM_018173403.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C306"/>
    <dbReference type="STRING" id="1460663.A0A177C306"/>
    <dbReference type="GeneID" id="28756889"/>
    <dbReference type="InParanoid" id="A0A177C306"/>
    <dbReference type="OrthoDB" id="4187847at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008496">
        <property type="term" value="F:mannan endo-1,6-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009272">
        <property type="term" value="P:fungal-type cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005198">
        <property type="entry name" value="Glyco_hydro_76"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014480">
        <property type="entry name" value="Mannan-1_6-alpha_mannosidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12145">
        <property type="entry name" value="MANNAN ENDO-1,6-ALPHA-MANNOSIDASE DCW1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12145:SF36">
        <property type="entry name" value="MANNAN ENDO-1,6-ALPHA-MANNOSIDASE DCW1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03663">
        <property type="entry name" value="Glyco_hydro_76"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAG02003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="289" mass="31374" checksum="070BE5063D946521" modified="2016-09-07" version="1" fragment="single">LVVTAAQIAQSIKSSLPNPSLVLVPQPYYWWQSGIVNNALFTYGFVTGDKQFEDLAKNTLYNQATAANDFMMPDATGNDDQAWWALSALTAAENNVAVPAGSPTFLSMAQNVFNEQKGRWDESSCSGGMRFKINAGDVGYEYKSSIANGLFFQLAARLAKLTGDADAKAWAEKSYDWIASTGLIDTDFNVYDGTDAASGCVDLNHNQWSYNAGVFLYGAAVMASQTGDAKWADRTNGLLAAAQRNFVRDSALYEPICEDQGTCNNDQVSFKGILARWLGATAVERPDLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C314</accession>
    <name>A0A177C314_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zinc finger PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CC84DRAFT_1221051</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441557">
        <property type="protein sequence ID" value="OAG01561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031926.1">
        <property type="nucleotide sequence ID" value="XM_018183223.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C314"/>
    <dbReference type="STRING" id="1460663.A0A177C314"/>
    <dbReference type="GeneID" id="28766709"/>
    <dbReference type="InParanoid" id="A0A177C314"/>
    <dbReference type="OrthoDB" id="5411773at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Zinc finger PHD-type" evidence="5">
        <location>
            <begin position="541"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="300"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="26"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="323"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAG01561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="640" mass="70856" checksum="774B970160742107" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C336</accession>
    <name>A0A177C336_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_185826</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441557">
        <property type="protein sequence ID" value="OAG01302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031667.1">
        <property type="nucleotide sequence ID" value="XM_018185509.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C336"/>
    <dbReference type="GeneID" id="28768995"/>
    <dbReference type="InParanoid" id="A0A177C336"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG01302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="143" mass="15352" checksum="12FA8947CFC8E5A6" modified="2016-09-07" version="1">MSSMQARVLAHQSGSCALMPMRCSPFGISPSPTRCSLLLPCTAPSTTQAAQSMRGAQDGFRHGSGAVQARSCTRPASLKGKASRHSKCIRNAPHNRLHSPRVDCLSGMCRPSAQHQQSVFAPASSSQPWKKTNHMRTKSHEVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C3A2</accession>
    <name>A0A177C3A2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_281285</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441558">
        <property type="protein sequence ID" value="OAG01268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031633.1">
        <property type="nucleotide sequence ID" value="XM_018185759.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C3A2"/>
    <dbReference type="GeneID" id="28769245"/>
    <dbReference type="InParanoid" id="A0A177C3A2"/>
    <dbReference type="OrthoDB" id="10405866at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG01268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="81" mass="8786" checksum="15A8788610DBB6D7" modified="2016-09-07" version="1">MSHARFHQAILHLGLRSCTRSQGNLACSILPALATVAVKITSPEYETRPVQEIEAPRLGSASKVLFLNAEVRLDGANVGRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C3M9</accession>
    <name>A0A177C3M9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CC84DRAFT_1198636</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441557">
        <property type="protein sequence ID" value="OAG01387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031752.1">
        <property type="nucleotide sequence ID" value="XM_018181579.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C3M9"/>
    <dbReference type="STRING" id="1460663.A0A177C3M9"/>
    <dbReference type="GeneID" id="28765065"/>
    <dbReference type="InParanoid" id="A0A177C3M9"/>
    <dbReference type="OrthoDB" id="2264294at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001080">
        <property type="term" value="P:nitrogen catabolite activation of transcription from RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050797">
        <property type="entry name" value="Carb_Metab_Trans_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668">
        <property type="entry name" value="GLUCOSE TRANSPORT TRANSCRIPTION REGULATOR RGT1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668:SF4">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN DAL81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="10"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="46"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="55"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="83"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAG01387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="599" mass="67026" checksum="50F1B52324201151" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C3U9</accession>
    <name>A0A177C3U9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tat pathway signal sequence</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1220740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ustYa family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441556">
        <property type="protein sequence ID" value="OAG02414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032779.1">
        <property type="nucleotide sequence ID" value="XM_018183196.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C3U9"/>
    <dbReference type="STRING" id="1460663.A0A177C3U9"/>
    <dbReference type="GeneID" id="28766682"/>
    <dbReference type="InParanoid" id="A0A177C3U9"/>
    <dbReference type="OrthoDB" id="3687641at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021765">
        <property type="entry name" value="UstYa-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365:SF12">
        <property type="entry name" value="TAT PATHWAY SIGNAL SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365">
        <property type="entry name" value="YALI0B05434P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11807">
        <property type="entry name" value="UstYa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00035112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG02414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="205" mass="23943" checksum="8A7A74CD2554AB7F" modified="2016-09-07" version="1">MFHFGTDLAKNPPSAPWKPLSVGYVLSEEHSVDHDKYSRFSGSPTHENTKAWEDLIQRKPTFFAATDHELRAGGETIDDAVRVADTDGYLAALGVYHELHCLRQLRLHLYRDVYFTNLTEANLQWFYDHLDHCIETLRISIMCQADLSLYTFKWDSNDEYRPHAKSNSKRMCVNWDEVERWSSERKVSLWPRLIRKGGSSEKIHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C3Y9</accession>
    <name>A0A177C3Y9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1167077</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441556">
        <property type="protein sequence ID" value="OAG01881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032246.1">
        <property type="nucleotide sequence ID" value="XM_018179114.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C3Y9"/>
    <dbReference type="GeneID" id="28762600"/>
    <dbReference type="InParanoid" id="A0A177C3Y9"/>
    <dbReference type="OrthoDB" id="3707219at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG01881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="63" mass="6842" checksum="419968DF9833F10B" modified="2016-09-07" version="1">MPAAPKSFVGALATFIIGSFTYTAYVARYEGNQIDAARTRWQDQMRRGNAAMSGGVSLLEPTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2023-06-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C4F8</accession>
    <name>A0A177C4F8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1178239</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG02624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032989.1">
        <property type="nucleotide sequence ID" value="XM_018180326.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C4F8"/>
    <dbReference type="GeneID" id="28763812"/>
    <dbReference type="InParanoid" id="A0A177C4F8"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG02624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="301" mass="32356" checksum="1AFF5E61A7FDDF9B" modified="2016-09-07" version="1">MPECTRLLAMHGSIGRLFGPRIERAPRLKRRPVAGSAISIWPAQADNYSANQGPCSAESGFGHGDSAKGTFIYRPMLAPAGQVISKQRSPRCAATFARLAGMHDGATDERKPSAISLSLSTARGRASWHVQSHVGLGASGSRHACLRWCCLIAGRAHLPQIVPLPIGDVMQQRRWLTAGRWREASRETASTGAFLWEHASKSPQRPCRVGSEARVWSESQAHPGGDGVGDRRLLAVVFLQCRSTALHMAIRHARVGASADTTSEEWECSCTLAARAGCAASRDSLQCARSRASDRMGDGLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C522</accession>
    <name>A0A177C522_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CC84DRAFT_1208051</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441556">
        <property type="protein sequence ID" value="OAG01868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032233.1">
        <property type="nucleotide sequence ID" value="XM_018182138.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C522"/>
    <dbReference type="GeneID" id="28765624"/>
    <dbReference type="InParanoid" id="A0A177C522"/>
    <dbReference type="OrthoDB" id="2410195at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016461">
        <property type="entry name" value="COMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001077">
        <property type="entry name" value="COMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712:SF1">
        <property type="entry name" value="HYPOTHETICAL O-METHYLTRANSFERASE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00891">
        <property type="entry name" value="Methyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51683">
        <property type="entry name" value="SAM_OMT_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="O-methyltransferase C-terminal" evidence="4">
        <location>
            <begin position="236"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAG01868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="400" mass="45275" checksum="D486664B8CA15423" modified="2016-09-07" version="1">MASNDINYEVLAHQIESILKDSETATAKLGNEATRRRLVEGARKLSVALETNRETLRRIGYAHLQLPFALVGVESKLFATLAAEPRPFNITEISEKTGIHLNLLKRLLRYYQATEVITQSDDDSYQANNITRALSNDDHANSLRWTRRITAHGALNLPDWLEKIEYKDPVGILPTAWSSTLNIEDKHPYAWLAVNPWALELAQAHMRVQRKGRPLFFDGLNFEERFAQNTDSETVLFVDVGGSTGPQSRELRKRFPNLKGRVILQDRPEVVAQAKEELKTMDIEAEVHDIFTPQTVRGARTYYLRNIFHAWGDPTCKQILVNAKEGLTEDSVLLIDEIVLPERDATAQGAQHDVEVMICVGGIERTKAHWENLLNSAGLQLREVINYDTEFEDSVIVVGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C545</accession>
    <name>A0A177C545_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ARM repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CC84DRAFT_1190016</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">RNA-binding nucleolar protein required for pre-rRNA processing. Involved in production of 18S rRNA and assembly of small ribosomal subunit.</text>
    </comment>
    <dbReference type="EMBL" id="KV441557">
        <property type="protein sequence ID" value="OAG01800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032165.1">
        <property type="nucleotide sequence ID" value="XM_018181090.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C545"/>
    <dbReference type="STRING" id="1460663.A0A177C545"/>
    <dbReference type="GeneID" id="28764576"/>
    <dbReference type="InParanoid" id="A0A177C545"/>
    <dbReference type="OrthoDB" id="668540at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003730">
        <property type="term" value="F:mRNA 3'-UTR binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010608">
        <property type="term" value="P:post-transcriptional regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07920">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033133">
        <property type="entry name" value="PUM-HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033712">
        <property type="entry name" value="Pumilio_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001313">
        <property type="entry name" value="Pumilio_RNA-bd_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537:SF48">
        <property type="entry name" value="MEIOTIC COILED-COIL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537">
        <property type="entry name" value="RNA BINDING PROTEIN PUMILIO-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00806">
        <property type="entry name" value="PUF"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00025">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50302">
        <property type="entry name" value="PUM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50303">
        <property type="entry name" value="PUM_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PUM-HD" evidence="6">
        <location>
            <begin position="357"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="3">
        <location>
            <begin position="419"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="3">
        <location>
            <begin position="455"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="3">
        <location>
            <begin position="603"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="3">
        <location>
            <begin position="647"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="333"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="150"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="346"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAG01800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="740" mass="82770" checksum="EDB4E75E278035BF" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C599</accession>
    <name>A0A177C599_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 14">beta-glucosidase</fullName>
            <ecNumber evidence="5 14">3.2.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CC84DRAFT_1262846</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 14">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 14">Glycan metabolism; cellulose degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="5 14"/>
    <dbReference type="EMBL" id="KV441557">
        <property type="protein sequence ID" value="OAG01850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032215.1">
        <property type="nucleotide sequence ID" value="XM_018185181.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C599"/>
    <dbReference type="STRING" id="1460663.A0A177C599"/>
    <dbReference type="GeneID" id="28768667"/>
    <dbReference type="InParanoid" id="A0A177C599"/>
    <dbReference type="OrthoDB" id="416222at2759"/>
    <dbReference type="UniPathway" id="UPA00696"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000757">
        <property type="entry name" value="Beta-glucosidase G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.300:FF:000002">
        <property type="entry name" value="Probable beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050288">
        <property type="entry name" value="Cellulose_deg_GH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019800">
        <property type="entry name" value="Glyco_hydro_3_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715">
        <property type="entry name" value="BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715:SF5">
        <property type="entry name" value="BETA-GLUCOSIDASE M-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="Beta-D-glucan exohydrolase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00775">
        <property type="entry name" value="GLYCOSYL_HYDROL_F3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 14" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12 14 17" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="8 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13 14" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="7 15" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008057740" description="beta-glucosidase" evidence="15">
        <location>
            <begin position="20"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type III-like" evidence="16">
        <location>
            <begin position="685"/>
            <end position="751"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU361161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="OAG01850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="763" mass="82811" checksum="0150AC710DC9BF49" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C5B8</accession>
    <name>A0A177C5B8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative NmrA-like family domain-containing protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CC84DRAFT_1251729</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441556">
        <property type="protein sequence ID" value="OAG01870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032235.1">
        <property type="nucleotide sequence ID" value="XM_018184336.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C5B8"/>
    <dbReference type="STRING" id="1460663.A0A177C5B8"/>
    <dbReference type="GeneID" id="28767822"/>
    <dbReference type="InParanoid" id="A0A177C5B8"/>
    <dbReference type="OrthoDB" id="419598at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051164">
        <property type="entry name" value="NmrA-like_oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748">
        <property type="entry name" value="NITROGEN METABOLITE REPRESSION PROTEIN NMRA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748:SF30">
        <property type="entry name" value="NMRA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="4">
        <location>
            <begin position="6"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAG01870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="313" mass="35521" checksum="E0946DF7923843DD" modified="2016-09-07" version="1">MSSAEHTVFISSATGYQGLALSKKLREMDWNVHATTRDLSSPAAVTLKEIGVQLKEADWDNLDVLRESIKGCDKLWLCLLPDWDDPTRERRQCANMLDIAKEAGVKQVIASTTLGVSQLDANVRVYPGSFMEKHMLNKKAVETSVEERGFEHFTFLRPTFFMANFLEPKVKRYDEIRDHRSWTTSMTAETQLPILDHHDIARFAVVAFQDPAKFHGRKIGLASDQMGIQEMLSMLAEAADQPGSIKAHFLTDEEIEAQAQGSGFANTHKVLRTASDYIDFDELRAIVPSLTSFKEFLEREKETVKRTFPHRNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C5N7</accession>
    <name>A0A177C5N7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1167508</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441556">
        <property type="protein sequence ID" value="OAG02461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032826.1">
        <property type="nucleotide sequence ID" value="XM_018179191.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C5N7"/>
    <dbReference type="STRING" id="1460663.A0A177C5N7"/>
    <dbReference type="GeneID" id="28762677"/>
    <dbReference type="InParanoid" id="A0A177C5N7"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF10">
        <property type="entry name" value="ABC TRANSMEMBRANE TYPE-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG02461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="366" mass="40624" checksum="966F39EB3943C761" modified="2016-09-07" version="1">MSAATSVPAAPDPAPAPAPAPSAEELPPVPAPADQDANQEVTTLEADTATPSDSDADSAFDGESSASTSLASSILNYEYSNGRRYHGYRSGAYVLPNDEDEQDRLDLLHHIFLLLLDGKLFAAPIAPARVLDIGTGTGIWALDFGDENPGSEVLGTDLSPIQPSWVPPNVKFYIDDAESEWVYSPHERFDLIHARGLSGAINDWEKLCRQCYENLQPGGWLEFQEPMAWVESDDGTIERAHNLRDWQQLCNDAAAKFGKVIKVGHTLKERLLGAGFVDVHEKIVKVPIGPWPKDPKMKEIGRYQREHMVIGIEPYTLGFLGKILGWSETECKIIIAKVREEVRDKNLHMYIRFYFVYGRKPESAVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C661</accession>
    <name>A0A177C661_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nucleic acid-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1261574</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG02896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033261.1">
        <property type="nucleotide sequence ID" value="XM_018185076.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C661"/>
    <dbReference type="GeneID" id="28768562"/>
    <dbReference type="InParanoid" id="A0A177C661"/>
    <dbReference type="OrthoDB" id="3248508at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008310">
        <property type="term" value="F:single-stranded DNA 3'-5' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052469">
        <property type="entry name" value="MEIOB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21166">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 24 OB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21166:SF2">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 24 OB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG02896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="468" mass="52205" checksum="F846A765A0AE0EF9" modified="2016-09-07" version="1">MPASSSSPVKVTPGDGFTPEELQVSPPTSTWVPTLDYEESDIASLEPGPRHLALMGRVVNFYDMPKPSKRPKAAQGLVKIMVADDTGTMFVRLWYAKTTYPLQLGQLVTLWTIHISQGDGQVGLAPSAAPLFTSIFPENERNCHFMIHDRSDDRSMFKRPFGARDSQVLPGLMTLKSFVDGGFDIDDCKLMVCVRSIGPRKKYTNKNGSISDLITAVVFDDSSEGHLTLYGSVSGSASAWKPYATVLLITAPGWRIDKTAKLSLNANTRVFIDPSIAEARYLRALAQRLTKKEHVNPPFPYDLFDTKEAELSTVKVLYKLSEIDEFARTNPREKAVGYMSIIVTELHILTNYKREMLMSNECCGKPIFASKVKARCRQCDRECTLRINPRILGDVIDETGTISTGKLIFSDTAWEQLLGRTAEQLVTASLDVIKYLEQRLLFLRLTLGFGIYLGSEEIGRLVVWCVKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2023-06-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C6S8</accession>
    <name>A0A177C6S8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_958042</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG03106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033471.1">
        <property type="nucleotide sequence ID" value="XM_018187951.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C6S8"/>
    <dbReference type="GeneID" id="28771437"/>
    <dbReference type="InParanoid" id="A0A177C6S8"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG03106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="191" mass="20968" checksum="F9C70E1630E72A28" modified="2016-09-07" version="1">MYLLSYTLLLHVREESGYTAGRRLGLHSQPRKPAWDFLYRCCKPQAYDPEAKHGPRREDACSGALGGAYSLSKVAVQRGRDAGISASNSSRSLARVTGLLRGDPIALALEGSLYLELTSPQHHGRKPSFGSSATVFAVSDHLSWWEMKWGRAGNGKRILPSEFDLKILLPGAAQHGLWIRLDDGLEAVRPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C7Z6</accession>
    <name>A0A177C7Z6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1178529</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG02972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033337.1">
        <property type="nucleotide sequence ID" value="XM_018180350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C7Z6"/>
    <dbReference type="GeneID" id="28763836"/>
    <dbReference type="InParanoid" id="A0A177C7Z6"/>
    <dbReference type="OrthoDB" id="10486186at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG02972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="180" mass="18979" checksum="D51AA1E16A9E5736" modified="2016-09-07" version="1">MASRPHSFYSQTKGPSVAVRRPGWANLCGGACVGARCFEPLCAHTWGDASTESEAARGSEHNARKPWARRGSRVCAGMRCVVGMNLPSSGHVAPLRLPSIASPGSPTVFTAGVYVFIQGLEGSMGTCLAAQPPGHYSAAAAASRASTSTAEAQYWLVKLFLWKESLAGRIHTSATFFLAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C835</accession>
    <name>A0A177C835_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_859888</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG03566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033931.1">
        <property type="nucleotide sequence ID" value="XM_018187650.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C835"/>
    <dbReference type="STRING" id="1460663.A0A177C835"/>
    <dbReference type="GeneID" id="28771136"/>
    <dbReference type="InParanoid" id="A0A177C835"/>
    <dbReference type="OrthoDB" id="5372935at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038883">
        <property type="entry name" value="AN11006-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085:SF2">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG03566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="392" mass="45147" checksum="E02676AD7F0A8046" modified="2016-09-07" version="1">MASDSSSLSPDIDRDSSPKLGSSNFTTQYSKKTGRPIRRSAGKAKPTDGYVDSKVIEDEYEEPIETPSEDEDGHIKPTQKRKRKRSPSPEPPPLDDVIRNDEPDERSEDEDPFQKKSKLPPIELQFNVPLGFHGPLVVKLDRSLLVPDTAYDMRPGLAMKKIRAGSGVDSQPSDGGKKPLGFADLPAELRNKVYRHLFVTEEKIMFPDAENMSRSSQFLSTCKLVHNEGCSILYGENKFRFDRNHKTRGPFWEPLPKEIGYKDVRQFLKMIGSENLVYLRDITLFLSDALPSTTPELTHESRRYLHDEHLLDVLRTLRQAKLRKLNVLFTGRRSLARNDTKFVEYLMQVKADEVISDTGTGWYYHNRKIESYIWKELKEKMTRKKKLYLPEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C8B8</accession>
    <name>A0A177C8B8_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">LigT-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1197472</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG03883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034248.1">
        <property type="nucleotide sequence ID" value="XM_018181524.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C8B8"/>
    <dbReference type="GeneID" id="28765010"/>
    <dbReference type="InParanoid" id="A0A177C8B8"/>
    <dbReference type="OrthoDB" id="10263155at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1140.10">
        <property type="entry name" value="Cyclic phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009097">
        <property type="entry name" value="Cyclic_Pdiesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37474:SF1">
        <property type="entry name" value="2'-5' RNA LIGASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37474">
        <property type="entry name" value="RNA LIGASE/CYCLIC NUCLEOTIDE PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13563">
        <property type="entry name" value="2_5_RNA_ligase2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55144">
        <property type="entry name" value="LigT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG03883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="207" mass="23664" checksum="F11B59D4D129AFE2" modified="2016-09-07" version="1">MTPRRILIPAHLSHKSALVLLPPSAIEAPIEAVRRVHDKVFARWPPHINLIYPFLALPSVQGEGSWSPELKEHIRCRIKKVTRQIEPFHMSLLTEGPKSFIHTSKSRTVWLQPSSDLVSGLQAALQTEFAECHHDQRPFVPHLSLGQAESDAQQTRIRIELHNRVTEYSTDSETKELPWFVDTIYVIERKGFKDRFNIVGGIKLGED</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C8W3</accession>
    <name>A0A177C8W3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1177769</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG03826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034191.1">
        <property type="nucleotide sequence ID" value="XM_018180303.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C8W3"/>
    <dbReference type="GeneID" id="28763789"/>
    <dbReference type="InParanoid" id="A0A177C8W3"/>
    <dbReference type="OrthoDB" id="10676930at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="257"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="109"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="200"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="263"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG03826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="321" mass="35041" checksum="FA50BE1778F48A09" modified="2016-09-07" version="1">MLFMLWNAFQLSHHTYRNRNFTQGSRTRPLVQSPRSTTSQLLIHLSWTLTRTWNPELPRIRPSLRLICTHSYTAISEWLKTATLAVVRRTRGSSPPGTEPSQPIFITEPSPSSSASSPSQPHPGPCRNDSALDASNSSTSSSQSPAKSTTSEQIDRIIASVQAMKQETYNLIETKKADLRALAESKKDPEALEESKKTTDIPSHTTTTTTASETGIETTATPSLATLDGKCVLRPGDSTHHLPATLSAPITPVTPTFSVAHTSPASSQSSPRSSVAQVHGDEEETGPWTYTVPRARVSTHGNRTIRRLGASVMFALFDQRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C9S1</accession>
    <name>A0A177C9S1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Coronin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CC84DRAFT_1164827</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="7">Binds to F-actin.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the WD repeat coronin family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG04325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034690.1">
        <property type="nucleotide sequence ID" value="XM_018178573.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C9S1"/>
    <dbReference type="FunCoup" id="A0A177C9S1">
        <property type="interactions" value="334"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177C9S1"/>
    <dbReference type="GeneID" id="28762059"/>
    <dbReference type="InParanoid" id="A0A177C9S1"/>
    <dbReference type="OrthoDB" id="1850764at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030139">
        <property type="term" value="C:endocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990819">
        <property type="term" value="C:mating projection actin fusion focus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110085">
        <property type="term" value="C:mitotic actomyosin contractile ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071933">
        <property type="term" value="F:Arp2/3 complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051666">
        <property type="term" value="P:actin cortical patch localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071846">
        <property type="term" value="P:actin filament debranching"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034316">
        <property type="term" value="P:negative regulation of Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000601">
        <property type="term" value="P:positive regulation of Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000197">
        <property type="entry name" value="Coronin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015505">
        <property type="entry name" value="Coronin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015048">
        <property type="entry name" value="DUF1899"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10856">
        <property type="entry name" value="CORONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10856:SF0">
        <property type="entry name" value="CORONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08953">
        <property type="entry name" value="DUF1899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16300">
        <property type="entry name" value="WD40_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM01166">
        <property type="entry name" value="DUF1899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01167">
        <property type="entry name" value="DUF1900"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 8 9" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="DUF1899" evidence="11">
        <location>
            <begin position="4"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="77"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="133"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="175"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="396"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="434"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="467"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="511"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="521"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00062568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU280818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OAG04325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="623" mass="67836" checksum="54C5C7F8E37DEC44" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C9W4</accession>
    <name>A0A177C9W4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CipC-like antibiotic response protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1176659</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG04443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034808.1">
        <property type="nucleotide sequence ID" value="XM_018180236.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C9W4"/>
    <dbReference type="STRING" id="1460663.A0A177C9W4"/>
    <dbReference type="GeneID" id="28763722"/>
    <dbReference type="InParanoid" id="A0A177C9W4"/>
    <dbReference type="OrthoDB" id="9895617at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022234">
        <property type="entry name" value="DUF3759"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37450">
        <property type="entry name" value="CIPC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37450:SF1">
        <property type="entry name" value="CIPC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12585">
        <property type="entry name" value="DUF3759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG04443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="131" mass="15069" checksum="26F24B4D44BE0F5C" modified="2016-09-07" version="1">MPFGWGDSERAYDQVYQNDNFEENKSSFGHELVAGGAAFAGFKAFEDHQRKEGKPVSHQFAKELLAGFAGAEVDKLAETKGEDWFDREKAKRQAKQNAERMYDEHYIDNQGADQYDPNQYGAPQHFERRGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2023-06-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CA71</accession>
    <name>A0A177CA71_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_865611</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG03742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034107.1">
        <property type="nucleotide sequence ID" value="XM_018187698.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CA71"/>
    <dbReference type="GeneID" id="28771184"/>
    <dbReference type="InParanoid" id="A0A177CA71"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG03742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="151" mass="16774" checksum="02EA4E21FD6B8003" modified="2016-09-07" version="1">MKREGPVLARGNGSAHAMARALARRGEHRCLFLSQLGPSQTNNFNFCITRQAFLPLVMVMMPGSPDSCRDTPFMFYIQPKVQLWLQKVQNDKKPVEHGVVASLTSYNTGGCKCKPQVWPDCPRCCSATLDLIFARRPFLPVAYVLSSQAGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CAA2</accession>
    <name>A0A177CAA2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SGNH hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1120979</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG04505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034870.1">
        <property type="nucleotide sequence ID" value="XM_018175597.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CAA2"/>
    <dbReference type="FunCoup" id="A0A177CAA2">
        <property type="interactions" value="238"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CAA2"/>
    <dbReference type="GeneID" id="28759083"/>
    <dbReference type="InParanoid" id="A0A177CAA2"/>
    <dbReference type="OrthoDB" id="671439at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01838">
        <property type="entry name" value="Isoamyl_acetate_hydrolase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045136">
        <property type="entry name" value="Iah1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14209">
        <property type="entry name" value="ISOAMYL ACETATE-HYDROLYZING ESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14209:SF19">
        <property type="entry name" value="ISOAMYL ACETATE-HYDROLYZING ESTERASE 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SGNH hydrolase-type esterase" evidence="1">
        <location>
            <begin position="10"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG04505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="264" mass="29361" checksum="F581586C44610B27" modified="2016-09-07" version="1">MAATWDKILLFGDSITQDSFNQQRGFGFSAGLQHEYIRRLDVVNRGFSGYTSRQALKILPHIVPAPSAANIRLLVVFLGANDASRPEAENKQHVPLDEYVSNLEKIITHPSVTAHKPKVVLVAPAPIDEHLVWANDQTQGRAAVSRKNVDLKKYSEAAAGLGEKLGVPVVNLWKAFMANTGWSEGKWKESEPILGALELPQNEELVRLLHDGLHFNPAGYQILLVEFLKVIRESYPELAPENVPLLLPLWNDAEGWATWDAAHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CAR7</accession>
    <name>A0A177CAR7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CC84DRAFT_1250008</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG04251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034616.1">
        <property type="nucleotide sequence ID" value="XM_018184297.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CAR7"/>
    <dbReference type="GeneID" id="28767783"/>
    <dbReference type="InParanoid" id="A0A177CAR7"/>
    <dbReference type="OrthoDB" id="6509908at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF281">
        <property type="entry name" value="ASPYRIDONES EFFLUX PROTEIN APDF-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="91"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="120"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="147"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="179"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="220"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="247"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="272"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="310"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="344"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="5">
        <location>
            <begin position="182"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="22"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="35"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAG04251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="377" mass="39507" checksum="F6D93D86B9EB5AEA" modified="2016-09-07" version="1">MSAPDSSSESITKGKRYSANKDLGWESLETGSKFGPEEKEEEQREGGQQAWLTVAGSSLIYFATLGTTNSFGFFQNYYEHTFLQGVPASTISFVGTLQITLTNVLAAPAGALFDCYGLKALYMFSAISCSGAFLGLSFIHSGSLSQIFLVQGVLLGLANACGSQPALVVVGQHFEHRRALVMGIVAAAGSVGAMLGQFIPYYYISTYVQATNPTSSAKDYLLPLMNASSIIGRILGGLAADSTGAGNAVYPMTILSGLLCLGTWAVTSSIPLLVIFVLLYGFCSGVFVAVLPVIVAQITPADKLGGRIGAFYMVSAVAQLVGSPIGGALIQGRSGLGSDQAQGYLGLIVFAGTTLLVGGIVILISRLLHDRNLRSRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CCU6</accession>
    <name>A0A177CCU6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1216813</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG05465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035830.1">
        <property type="nucleotide sequence ID" value="XM_018182840.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CCU6"/>
    <dbReference type="GeneID" id="28766326"/>
    <dbReference type="InParanoid" id="A0A177CCU6"/>
    <dbReference type="OrthoDB" id="2958217at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008058015" evidence="1">
        <location>
            <begin position="17"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG05465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="380" mass="42252" checksum="7D3C7832FC18E4C2" modified="2016-09-07" version="1">MLAFGASVLAAPAAEAAPVPEANPAPTPEAASSLVARTGEYLGGIDMNTACREQWFRFAYAYQVDNSCNAWKCEEYVDYCHYYNIAWDTLEWQLVWPQLLDDARLILEASDVLLSGPTNDEASITPPIVDEDKGIIFSGFADDFHDNFVFYRDTLGFGPFVKTNRKPYDLAVACVLLRAFLLAPECVHLNSDGYWTDEEWIDAVTLYKQLWPDEQIECPWGITRQARYHLTGKADRLIHDGGTAQPVNQSARACVAATAVDEKSCAIHGEIAGLDRAQKWLATCDQDLEHVACGAAPITWLQLPGVSLKVIDVERACIVEAPKHCFFMALTYVWGKINHPKLTSKTAAVLMQEGGLDTIWSDIPMTTRDAILLCRRLKDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CCX0</accession>
    <name>A0A177CCX0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative short-chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1246898</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG04649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035014.1">
        <property type="nucleotide sequence ID" value="XM_018184215.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CCX0"/>
    <dbReference type="STRING" id="1460663.A0A177CCX0"/>
    <dbReference type="GeneID" id="28767701"/>
    <dbReference type="InParanoid" id="A0A177CCX0"/>
    <dbReference type="OrthoDB" id="5336600at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43669">
        <property type="entry name" value="5-KETO-D-GLUCONATE 5-REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43669:SF4">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG04649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="228" mass="24156" checksum="156211507638FD08" modified="2016-09-07" version="1">MASRSGVILILGAGANIGQHVAQQFASQGYKVASTSRSAKSADNTSDAVHIVADLSDPESVAGIFSQVKASLGVPSVVVYNAAAASFKDAKNPVTLSLAELSKSLNVNTLSAYAALQEAIQGFEQLPETSSRTFIYTGNILNTTVMPQLLDLGVGKSATAHAIQVAATAYSDRGFKFYYADERKADGTPPYNDIDGEAHGKFYAELAKGMKQGDWQQTFVKGEGYKKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CD70</accession>
    <name>A0A177CD70_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1206328</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG04728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035093.1">
        <property type="nucleotide sequence ID" value="XM_018182027.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CD70"/>
    <dbReference type="STRING" id="1460663.A0A177CD70"/>
    <dbReference type="GeneID" id="28765513"/>
    <dbReference type="InParanoid" id="A0A177CD70"/>
    <dbReference type="OrthoDB" id="3800160at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="274"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="308"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="320"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="339"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG04728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="452" mass="53230" checksum="5F1CD64C6619871E" modified="2016-09-07" version="1">MPKYVRPYFDHREWVRDGITLGDFESVCNFKHPIDRYDLRQVGPHLVQMASQLVECASLVCPAPMCEAGRGPKFRRRVMETIRRIHEIADDIDIVVPVRIVTGMVGIIGAGNSSSRTVVRTVLPQELSRRVVEERIYQPAPIHETETKTWVHRAHGSKYLARVETKTYDRSQPEVEEVSRDENRGHKRGKKKKSQRRMIKERGESSDEEKGKRRRSRDRGHDRHRSKSRDRERGRRSGKDTYKDRDDDRRRSRSRSRDREHERHMSRDRRRIKDRSSSRDRHKEQNRRKSNDCSRHECSKDKDEYRKKHERRPRSRERSRRRDDRDKHKYDESEREYDSSPSRRSSSSSSSASRSNSRRMGATMGCVLWPEARFQCYVYGDFESELQHCICFYFLSGIYISKFTIMSSKYQTRRCDGVVNVIDSNQSGLARFAISISFGSAGSNPADVGFFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CDE1</accession>
    <name>A0A177CDE1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CC84DRAFT_1246981</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG04720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035085.1">
        <property type="nucleotide sequence ID" value="XM_018184220.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CDE1"/>
    <dbReference type="GeneID" id="28767706"/>
    <dbReference type="InParanoid" id="A0A177CDE1"/>
    <dbReference type="OrthoDB" id="3639251at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000188">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF3">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="59"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="101"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="130"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="154"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="192"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="224"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="299"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="332"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="363"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="390"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="422"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="453"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="63"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAG04720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="500" mass="56822" checksum="45B198915FC96926" modified="2016-09-07" version="1">MSHQTTTGGQTASEKTEFNEFEAFDEETGVTKQEVNRHINETTLSDTQKKREAKVLRKVDWRLIPILGLLYSVAGLDRVNLSNARVAGMNKDLRFDIGNRYSIALLVFFITYFLFELPTTLLLRPLKPRYLLNGLAVCWGSVMLGMGFINDWRYIVVCRMLIGVFEAGYLPCCMFLLATWYQRFEVQSRISWWYLINLFVSAFGNILAFAIVKLDGVHGIAGWRWIFIVEGAATLGIALIGFFLVIDFPDRMLATNKLQGFTQDELQIILDRIDRDRGDSQPDKLTWEKFTRHVVNWELWVYGFMFLTCSAPIYAFAYFIQIILGTIVDSTAVVFLLCAPPYLFSIIWTVLCAWLADRSHLRMPWMVGNAVITLTGLLITAYSTNPGARYFGVFLGVSGCNANLPTIIALQSNNVRSDSRRSVANGVQLLFAAIGGIYASTTFMQKEYPTYRTGVWCAVATQFLLIILCAGMFLHFRKENKAADEYGEVIQEDEGFRYTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CDI3</accession>
    <name>A0A177CDI3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NADH-ubiquinone oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1093970</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG04828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035193.1">
        <property type="nucleotide sequence ID" value="XM_018174545.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CDI3"/>
    <dbReference type="STRING" id="1460663.A0A177CDI3"/>
    <dbReference type="GeneID" id="28758031"/>
    <dbReference type="InParanoid" id="A0A177CDI3"/>
    <dbReference type="OrthoDB" id="307899at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.260.40:FF:000003">
        <property type="entry name" value="NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.260.40">
        <property type="entry name" value="q5lls5 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019401">
        <property type="entry name" value="Znf_CHCC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13156:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 6, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13156">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 13 KD-A SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10276">
        <property type="entry name" value="zf-CHCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="Zinc finger CHCC-type" evidence="2">
        <location>
            <begin position="121"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG04828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="200" mass="22031" checksum="08BB65FDCBD0F790" modified="2016-09-07" version="1">MLARTLRARSAARGLSFFRAYSTPNDPVKRDVPQTVSETNATPTSSEGAFDKVLQESVAKAEQLRTTQAPNYKGTWSTSQQARAVAMQGPRFEQTIIEDQPRPYAAIDLIHKQPVRWTHDRVVSCDGGGGPLGHPRIFINVDKPQICACTYCGLPFAHEHHRATLEAIPESQLSYPLAPKGDPAEVDASQRITNEPLGQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CDN3</accession>
    <name>A0A177CDN3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">mitogen-activated protein kinase kinase kinase</fullName>
            <ecNumber evidence="2">2.7.11.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CC84DRAFT_1177052</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.25"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.25"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.25" evidence="2"/>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG04909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035274.1">
        <property type="nucleotide sequence ID" value="XM_018180260.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CDN3"/>
    <dbReference type="FunCoup" id="A0A177CDN3">
        <property type="interactions" value="149"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CDN3"/>
    <dbReference type="GeneID" id="28763746"/>
    <dbReference type="InParanoid" id="A0A177CDN3"/>
    <dbReference type="OrthoDB" id="266718at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004709">
        <property type="term" value="F:MAP kinase kinase kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd09534">
        <property type="entry name" value="SAM_Ste11_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000334">
        <property type="entry name" value="Serine/threonine-protein kinase STE11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000214">
        <property type="entry name" value="Serine/threonine-protein kinase STE11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000387">
        <property type="entry name" value="Serine/threonine-protein kinase STE11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029458">
        <property type="entry name" value="Ras-bd_By2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11584:SF369">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 19-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11584">
        <property type="entry name" value="SERINE/THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14847">
        <property type="entry name" value="Ras_bdg_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00536">
        <property type="entry name" value="SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01304">
        <property type="entry name" value="Ras_bdg_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM" evidence="13">
        <location>
            <begin position="68"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="681"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="127"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="580"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="156"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="212"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="224"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="605"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="630"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="710"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OAG04909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="957" mass="105679" checksum="1FCA744366D13EE0" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CDP5</accession>
    <name>A0A177CDP5_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Transcription elongation factor 1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CC84DRAFT_1164226</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10">Transcription elongation factor implicated in the maintenance of proper chromatin structure in actively transcribed regions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the ELOF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG05764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036129.1">
        <property type="nucleotide sequence ID" value="XM_018178448.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CDP5"/>
    <dbReference type="FunCoup" id="A0A177CDP5">
        <property type="interactions" value="649"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CDP5"/>
    <dbReference type="GeneID" id="28761934"/>
    <dbReference type="InParanoid" id="A0A177CDP5"/>
    <dbReference type="OrthoDB" id="445983at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008023">
        <property type="term" value="C:transcription elongation factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000993">
        <property type="term" value="F:RNA polymerase II complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.190:FF:000001">
        <property type="entry name" value="Transcription elongation factor 1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007808">
        <property type="entry name" value="Elf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038567">
        <property type="entry name" value="T_Elf1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20934">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20934:SF0">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05129">
        <property type="entry name" value="Zn_ribbon_Elf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="7 10" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6 10" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="85"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OAG05764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="125" mass="13745" checksum="B53A4C0D2B212A7B" modified="2016-09-07" version="1">MGKRKSAKKPQGPRKKEKLPTTFQCLFCNHENSVSVSIEKKSGVGNLQCKVCGQTFQTNTNYLSAPVDVYSDWVDACDAVAKEAAAANTSTSRPVNRGGRSRVEEETEDFVVQDDADAEGEYDDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CDR3</accession>
    <name>A0A177CDR3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">E2 ubiquitin-conjugating enzyme</fullName>
            <ecNumber evidence="1">2.3.2.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CC84DRAFT_810010</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.23" evidence="1"/>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG04949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035314.1">
        <property type="nucleotide sequence ID" value="XM_018187512.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CDR3"/>
    <dbReference type="FunCoup" id="A0A177CDR3">
        <property type="interactions" value="933"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CDR3"/>
    <dbReference type="GeneID" id="28770998"/>
    <dbReference type="InParanoid" id="A0A177CDR3"/>
    <dbReference type="OrthoDB" id="7851174at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd23813">
        <property type="entry name" value="UBCc_UBE2N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000020">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24068">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="8">
        <location>
            <begin position="3"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="6">
        <location>
            <position position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAG04949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="150" mass="16905" checksum="89D54780BE4EE014" modified="2016-09-07" version="1">MAALPKRIIKETERLSKEPVPGISAVPHDDNLRYFDVTIDGPAQSPYEGGVFKLELFLPDDYPMTPPKVRFLTKIYHPNIDRLGRICLDVLKSNWSPALQIRTILLSIQALLGAPNPDDPLANDVAQQWKEDQNQAIATAREWTEKFAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CDU7</accession>
    <name>A0A177CDU7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_808854</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG04900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035265.1">
        <property type="nucleotide sequence ID" value="XM_018187501.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CDU7"/>
    <dbReference type="STRING" id="1460663.A0A177CDU7"/>
    <dbReference type="GeneID" id="28770987"/>
    <dbReference type="InParanoid" id="A0A177CDU7"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051826">
        <property type="entry name" value="E3_ubiquitin-ligase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22765:SF450">
        <property type="entry name" value="ERAD-ASSOCIATED E3 UBIQUITIN-PROTEIN LIGASE HRD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22765">
        <property type="entry name" value="RING FINGER AND PROTEASE ASSOCIATED DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="3">
        <location>
            <begin position="256"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="85"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="28"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="85"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="112"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="124"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="142"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAG04900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="362" mass="41187" checksum="DA2C2842D779C4E1" modified="2016-09-07" version="1">MPSPPTLSSQCPARSVLTPSTLISNNHTRFDEEGRVDEVAGTPNDVGHPYPGFNLPSYSGPPDHPNLQWPQQLPRNFARHPQRTVPMTSSFSSDMFGTDTTVDETRNPQYHRNSEIPHPDVTSRRNPSYQRPHRQGSSDFNSPDRRHSSRSADGHAPLSELGSSLRTHNRRSFDRYSTDVPNGATGPNGPIRSPSSRGADRMAARRQRPIGHPLFRRMSSHMEHPNVPSTEQLRELREKLRHLLPAELPEGIDAMCDICQKDYSTKHVDPSEYDEVAIQLPCKHVFGEHCIHTWFDTCKKHKNKITCPMCRKVLIEPRCRENAQSRGQLLERLDRLRRQGDGGPFFEHMPRAIFEGRVAREP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CEL2</accession>
    <name>A0A177CEL2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CC84DRAFT_1122346</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG05239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035604.1">
        <property type="nucleotide sequence ID" value="XM_018175634.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CEL2"/>
    <dbReference type="FunCoup" id="A0A177CEL2">
        <property type="interactions" value="480"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CEL2"/>
    <dbReference type="GeneID" id="28759120"/>
    <dbReference type="InParanoid" id="A0A177CEL2"/>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000002">
        <property type="entry name" value="2,5-diketo-D-gluconic acid reductase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11732">
        <property type="entry name" value="ALDO/KETO REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00798">
        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00063">
        <property type="entry name" value="ALDOKETO_REDUCTASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="5">
        <location>
            <begin position="39"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="72"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="4">
        <location>
            <position position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAG05239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="337" mass="37103" checksum="D8403CBF72C73754" modified="2016-09-07" version="1">MNPSLANFILKLSPKDILNPTPTMNTAIPLNTGATIPALGLGTWQSAPGEVKKAVIHAIEGGYRHIDCAFCYQNEDEVGEALQDVISRGIVKREDLFITSKLWCTFHTRAEEGLQKSLDLLKTPYVDLYLMHWPVPMNPKGNHPLFPKLEDGSRDIDHSITHIDTWKNLEALYKAHPEKVKAIGVANYSVKYLEKLLAQSTITPAANQIENHPLLPQQEVVDFCRSKNIHITAYSPLGSTGSPLFKDAGVLDVAKKHDVGPGTVLLSYHLARGSSVLAKSVTPSRIDENRKLITLDEGDMQALEAIHKKNGVQRFVYPPFGVNAGFPDKTEGIDLSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CEU1</accession>
    <name>A0A177CEU1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CC84DRAFT_1119835</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG06144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036509.1">
        <property type="nucleotide sequence ID" value="XM_018175561.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CEU1"/>
    <dbReference type="STRING" id="1460663.A0A177CEU1"/>
    <dbReference type="GeneID" id="28759047"/>
    <dbReference type="InParanoid" id="A0A177CEU1"/>
    <dbReference type="OrthoDB" id="1274115at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05374">
        <property type="entry name" value="17beta-HSD-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051911">
        <property type="entry name" value="SDR_oxidoreductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43976">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43976:SF16">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAG06144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="281" mass="30877" checksum="0B894886996A430E" modified="2016-09-07" version="1">MSPRVFLITGTSTGFGAELVKVVLSKGDHVVATARDSSKLSFPEANSSNSILVDLDVTKKDSIDKAFDAAVKKFKRVDVVVNNAGYGLSGPFETLSDAQMRKQMDINFFGLIDVTRKAIQTMRDLKSGGVIQQITSIGGQIGVPSFSIYCASKWAVEGFTETVSKEVKPEWGIKFTCIEPGGFRTDWSGRSMEFGENRTDELDKAYDHIDPKKIASNRHMKQAGDPPKAAKVFYDLAVMEDPPLRCVVGTDAYKAISSKIDTYSENVEKFAKWSNSTDVDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CEX8</accession>
    <name>A0A177CEX8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1092259</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG05761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036126.1">
        <property type="nucleotide sequence ID" value="XM_018174444.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CEX8"/>
    <dbReference type="GeneID" id="28757930"/>
    <dbReference type="InParanoid" id="A0A177CEX8"/>
    <dbReference type="OrthoDB" id="3891636at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="19"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG05761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="150" mass="16780" checksum="A5E43F781197ACCE" modified="2016-09-07" version="1">MANNTRYYYSLPTQPPQQPRSTSGSRRPPLTPSTVSSPCLTTQSTIASRRDSGSGSPTKASALLAKVASHPSTPRAETPMGSPMSSPEERMHSSPMYSPDRPAVWRSESARYVHQYRQQDGYISFPDFEKFCQSQNPYQQPRREHSAVRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CFL0</accession>
    <name>A0A177CFL0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CC84DRAFT_1092167</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the archaeal Rpo12/eukaryotic RPC10 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG05732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036097.1">
        <property type="nucleotide sequence ID" value="XM_018174438.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CFL0"/>
    <dbReference type="STRING" id="1460663.A0A177CFL0"/>
    <dbReference type="GeneID" id="28757924"/>
    <dbReference type="InParanoid" id="A0A177CFL0"/>
    <dbReference type="OrthoDB" id="5585087at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.30">
        <property type="entry name" value="RNA polymerase ii, chain L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006591">
        <property type="entry name" value="RNAP_P/RPABC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039747">
        <property type="entry name" value="RPABC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029040">
        <property type="entry name" value="RPABC4/Spt4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12056">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12056:SF2">
        <property type="entry name" value="GEO11084P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03604">
        <property type="entry name" value="Zn_ribbon_RPAB4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00659">
        <property type="entry name" value="RPOLCX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63393">
        <property type="entry name" value="RNA polymerase subunits"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="24"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAG05732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="194" mass="21202" checksum="A78D879B51E28AF6" modified="2016-09-07" version="1">MEAANQDNDDGRSDADNNLTGNDNDNDNDNDNDNDNDNDNDNDNDNDNEGDDGDAANDLTGNDKDAPTAKPRLPRIGSGGIHISAPSTTKFANTAPKPHNGTNSAELEAGASGQSHLGYTGQWSDENRAVAYVCGTNWDISRYQEKERPANWPSKGWQCGEVVLKKGEPIRCKECGGRLLYKKRTDRMVQFEAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CG41</accession>
    <name>A0A177CG41_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amidase signature enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1244357</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG05809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036174.1">
        <property type="nucleotide sequence ID" value="XM_018184152.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CG41"/>
    <dbReference type="STRING" id="1460663.A0A177CG41"/>
    <dbReference type="GeneID" id="28767638"/>
    <dbReference type="InParanoid" id="A0A177CG41"/>
    <dbReference type="OrthoDB" id="1879366at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000120">
        <property type="entry name" value="Amidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895:SF170">
        <property type="entry name" value="AMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895">
        <property type="entry name" value="TRANSAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="1">
        <location>
            <begin position="93"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG05809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="541" mass="57923" checksum="BD0DAE6A6EB6A29F" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CGU8</accession>
    <name>A0A177CGU8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Oxidoreductase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1204482</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG06795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037160.1">
        <property type="nucleotide sequence ID" value="XM_018181908.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CGU8"/>
    <dbReference type="STRING" id="1460663.A0A177CGU8"/>
    <dbReference type="GeneID" id="28765394"/>
    <dbReference type="InParanoid" id="A0A177CGU8"/>
    <dbReference type="OrthoDB" id="48988at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029154">
        <property type="entry name" value="HIBADH-like_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43060">
        <property type="entry name" value="3-HYDROXYISOBUTYRATE DEHYDROGENASE-LIKE 1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43060:SF17">
        <property type="entry name" value="L-THREONATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14833">
        <property type="entry name" value="NAD_binding_11"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6-phosphogluconate dehydrogenase NADP-binding" evidence="1">
        <location>
            <begin position="7"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="3-hydroxyisobutyrate dehydrogenase-like NAD-binding" evidence="2">
        <location>
            <begin position="174"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="3-hydroxyisobutyrate dehydrogenase-like NAD-binding" evidence="2">
        <location>
            <begin position="317"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG06795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="432" mass="45439" checksum="0495E1EAB93EFEA8" modified="2016-09-07" version="1">MSSKPAIGFCGLGAMGFGMATHLVKQGYPVTGFDVYAPTLERFSAAGGTPSTSLSESAKDKAYYICMVATAQQAEQALFGDDGIVAGLPQGAVLYLTSTVPSSYAQSVEKKLADVGRGDIFFIDAPVSGGAIRAADGTLSIMAGASEAAFEKGKFLLDELTAPAKLFIVAGGVGAGSNMKMVHQVLAAIHIISVSEAFGFAARLGLNGSDVREHVIGGKAWSWMFENRSVRTLKEDYFPGASAVTIILKDTGIITSMANLVDFPVPLCSIAEQLYITGLNKDFGAQDDAGLVRLWTSEPVTSLAPLADEDKKAKLELVSNLLNGIHLCAAAEGISFAKHLGVPLAQYYELCVEAAGGSTQYKEQGTKMIDIIEGKQGHEGASLRSYRDGLKAAITEARDKKIPLHLGNGALTLIEQAGKEQSLSSLLKLYSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CH68</accession>
    <name>A0A177CH68_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Glycoside hydrolase/deacetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CC84DRAFT_1075024</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG06571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036936.1">
        <property type="nucleotide sequence ID" value="XM_018173705.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CH68"/>
    <dbReference type="FunCoup" id="A0A177CH68">
        <property type="interactions" value="40"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CH68"/>
    <dbReference type="GeneID" id="28757191"/>
    <dbReference type="InParanoid" id="A0A177CH68"/>
    <dbReference type="OrthoDB" id="2125469at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10951">
        <property type="entry name" value="CE4_ClCDA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00035">
        <property type="entry name" value="ChtBD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11618">
        <property type="entry name" value="ChtBD1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.10">
        <property type="entry name" value="Endochitinase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.370">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001002">
        <property type="entry name" value="Chitin-bd_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018371">
        <property type="entry name" value="Chitin-binding_1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036861">
        <property type="entry name" value="Endochitinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46471">
        <property type="entry name" value="CHITIN DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46471:SF2">
        <property type="entry name" value="CHITIN DEACETYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00187">
        <property type="entry name" value="Chitin_bind_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00270">
        <property type="entry name" value="ChtBD1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57016">
        <property type="entry name" value="Plant lectins/antimicrobial peptides"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00026">
        <property type="entry name" value="CHIT_BIND_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50941">
        <property type="entry name" value="CHIT_BIND_I_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2 8" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="7" id="KW-0170">Cobalt</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="NodB homology" evidence="10">
        <location>
            <begin position="17"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-1" evidence="9">
        <location>
            <begin position="238"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-1" evidence="9">
        <location>
            <begin position="297"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="254"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="259"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="313"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="318"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OAG06571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="345" mass="37329" checksum="CE9DF2EE84880958" modified="2016-09-07" version="1" fragment="single">ASPVPFGLQIYQCTKPGVIAPGFDDGPWIYSEDILDRMQATGFIATWFINGANKGNIYDYNSTLRRMVNMGHQIGSHTWSHKDLATLTVDGIKQQMILLEEAMVNILGYFPYYMRPPFLSVNAQALSVLKELQYHVIIGDLNTKDWEYQTQAGIEIAKKLFVDGLDMGYTIVESHEQEVWSQGVLIDYMIKIVKDRGLKTVTVAECLQDTQVYRTFRDPNASAKATATPLGPGSTTPDGTCGTQGSGKDKGYICKAGACCSKYGNCGTTFDYCAAPVCQIAFGRCDPAPGRGSVTPDGTCGDFSKGNNNGYVCKNGACCSKYGNCGTTNDYCAASSGCQPAFGSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CH77</accession>
    <name>A0A177CH77_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1217542</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG06302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036667.1">
        <property type="nucleotide sequence ID" value="XM_018182901.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CH77"/>
    <dbReference type="STRING" id="1460663.A0A177CH77"/>
    <dbReference type="GeneID" id="28766387"/>
    <dbReference type="InParanoid" id="A0A177CH77"/>
    <dbReference type="OrthoDB" id="5985073at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="362"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="377"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG06302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="566" mass="64860" checksum="F02F19EADACF452A" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CH79</accession>
    <name>A0A177CH79_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1176193</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG06140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036505.1">
        <property type="nucleotide sequence ID" value="XM_018180205.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CH79"/>
    <dbReference type="GeneID" id="28763691"/>
    <dbReference type="InParanoid" id="A0A177CH79"/>
    <dbReference type="OrthoDB" id="10675564at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG06140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="201" mass="22117" checksum="9FB066DCBF2BBBE1" modified="2016-09-07" version="1">MGPLVAFVQAQRARRSPTDATLITLASQHDEAQAPKRPSICGVQRSAEAEEKPGQADHASICALLDSIIVGVELVWTEWSRSSIVAVEHEEPASARLPVQCRMRERLPRYRLGGWFDGFVGLGGEGGVELGQNAFSSATKVSTLCQQLPLVRRWCLSRDLLQYAPKRLNLGPLGDQVSESRLLPSAYRGPRFYNCQAFLVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CHD5</accession>
    <name>A0A177CHD5_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF924-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1259497</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG06259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036624.1">
        <property type="nucleotide sequence ID" value="XM_018184918.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CHD5"/>
    <dbReference type="GeneID" id="28768404"/>
    <dbReference type="InParanoid" id="A0A177CHD5"/>
    <dbReference type="OrthoDB" id="414698at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010323">
        <property type="entry name" value="DUF924"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06041">
        <property type="entry name" value="DUF924"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG06259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="294" mass="32555" checksum="7CC68628D2882FCF" modified="2016-09-07" version="1">MATLITPTRLTSLFTSEVPWPKSTPPTPSNWAAEHSNFAEYKALGWPVLLALSKIPLPEAQALDWLAILPAPTSPDFPVQAVGLTVLLDQAPRHLCTGTHERWRNAFFDPLALGFARRLRALPASLAVHTWARWEREGWSFAHWSVLSNFVTAPLAHAEDLAVHEGLLLPEIAARRALVESHYAVRDELHDPHLATSSTATAEFARLIRVGMPPGADMPRTVFWWCRVNEAHTPIIRRFARYPYRNAALGRVSTPAELEFLAATGNFGVGLDGEEAARVRADVEDGIWTALGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CHX7</accession>
    <name>A0A177CHX7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1116890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG06916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037281.1">
        <property type="nucleotide sequence ID" value="XM_018175472.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CHX7"/>
    <dbReference type="GeneID" id="28758958"/>
    <dbReference type="InParanoid" id="A0A177CHX7"/>
    <dbReference type="OrthoDB" id="2253354at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035213">
        <property type="entry name" value="DUF5321"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17254">
        <property type="entry name" value="DUF5321"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG06916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="214" mass="23977" checksum="088EA91DE458502F" modified="2016-09-07" version="1">MDTHILLRQLLRQPHTARTLLSSATRPQPHTFALLSPKHSYARHLSVPTILRPAFWKSMIPRPLRSGESLSSTSDVPSRQWNPATPYIVLALLVGSQAIQILWLKQERALMTRRAEAKMGILREVVERVQRGEEVDVEGILGTGVEGREREWAGLLKEIEDEELLFQSTAEKRKLKEAAEAEARDEAAQSAGDAHNSPEEAKLKVESLGGAKFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CHZ2</accession>
    <name>A0A177CHZ2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1092550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG06440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036805.1">
        <property type="nucleotide sequence ID" value="XM_018174463.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CHZ2"/>
    <dbReference type="STRING" id="1460663.A0A177CHZ2"/>
    <dbReference type="GeneID" id="28757949"/>
    <dbReference type="InParanoid" id="A0A177CHZ2"/>
    <dbReference type="OrthoDB" id="5340195at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35041:SF3">
        <property type="entry name" value="FORMYLMETHIONINE DEFORMYLASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35041">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="516"/>
            <end position="535"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG06440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="638" mass="71403" checksum="1D6BE654012D8C34" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CI04</accession>
    <name>A0A177CI04_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF1593-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_765835</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG06489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036854.1">
        <property type="nucleotide sequence ID" value="XM_018187368.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CI04"/>
    <dbReference type="GeneID" id="28770854"/>
    <dbReference type="InParanoid" id="A0A177CI04"/>
    <dbReference type="OrthoDB" id="3592035at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016799">
        <property type="term" value="F:hydrolase activity, hydrolyzing N-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.245.10">
        <property type="entry name" value="Ribonucleoside hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036452">
        <property type="entry name" value="Ribo_hydro-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048527">
        <property type="entry name" value="Sde182_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011483">
        <property type="entry name" value="Sde182_NH-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21027">
        <property type="entry name" value="Sde0182_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07632">
        <property type="entry name" value="Sde182_NH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008058225" evidence="1">
        <location>
            <begin position="25"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="domain" description="Cellulose-binding Sde182 nucleoside hydrolase-like" evidence="2">
        <location>
            <begin position="30"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="Cellulose-binding Sde182 C-terminal" evidence="3">
        <location>
            <begin position="424"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF21027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAG06489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="505" mass="56102" checksum="81B49344587C741B" modified="2016-09-07" version="1">MFFSIPRLLTAGLLASVIPAHTISRTERFRTVVTTDMEQDDLASLVRYVLYTNELDTEGIIYTSSKYHWAGDGKNTKFFLPNREYNTSQTSWRWTGTRTIEDILLKAYAEIYRNLLVHDSAYPTPNDLLSKVKIGNIVFEGEMDQDTDGSNLIKSLLLDNDQRTLYLQAWGGTNTIARALKSISEQYAHTAQWLHLQASVSRKAVILASGFQDETYAAYIAPNWPALRVEDFSTAYNTWGFNCNKGQGNVRGLPDQHEFFTGAWIKANIQIGPLGRLYRSWLDGQHTPGDQLDVFGNYTLAAAPGTWCKPLGPYDFLSEGDNVAFNPLLTTGLQDASNPALGGWGGRSKLNSSTPELWQLVVTEKAANGSEVKDWTTNRWVEAASNDFAARMQWGLTSKYQQGNHAPQVKIVGGAKVRAKAGETVKLAARVSDPDRDAVTVSWWQYLEEGTYPGEVAVTSDKRRDASAMVPADAKSGQTISIIVQATDDGDFPLTRYDRVIITVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CI91</accession>
    <name>A0A177CI91_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_785385</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG06507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036872.1">
        <property type="nucleotide sequence ID" value="XM_018187374.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CI91"/>
    <dbReference type="STRING" id="1460663.A0A177CI91"/>
    <dbReference type="GeneID" id="28770860"/>
    <dbReference type="InParanoid" id="A0A177CI91"/>
    <dbReference type="OrthoDB" id="4424523at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG06507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="181" mass="20997" checksum="C01A436ECA3E32AC" modified="2016-09-07" version="1">MPDIDYLRKLCSRHPQMRLGFVVYRLTYENDYKWARFMDHLNTRTRLNLEKNGAGDLFPRIDWSVQEDPALEDADYDEVRKRFNRWVRDQSEDKEREPFSTRHLACVAVPMFHIDCVLKGPKPTQNDSLGYGWVALIRAEIEEDGEGCTQVGVSFLVPRAFSVLEIGWHAVDVGTQDVYAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CIN1</accession>
    <name>A0A177CIN1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF239-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1048778</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG06637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037002.1">
        <property type="nucleotide sequence ID" value="XM_018173444.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CIN1"/>
    <dbReference type="STRING" id="1460663.A0A177CIN1"/>
    <dbReference type="GeneID" id="28756930"/>
    <dbReference type="InParanoid" id="A0A177CIN1"/>
    <dbReference type="OrthoDB" id="1858978at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053168">
        <property type="entry name" value="Glutamic_endopeptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004314">
        <property type="entry name" value="Neprosin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31589:SF110">
        <property type="entry name" value="PROTEIN, PUTATIVE (DUF239)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31589">
        <property type="entry name" value="PROTEIN, PUTATIVE (DUF239)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03080">
        <property type="entry name" value="Neprosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52045">
        <property type="entry name" value="NEPROSIN_PEP_CD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Neprosin PEP catalytic" evidence="1">
        <location>
            <begin position="29"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS52045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG06637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="307" mass="33770" checksum="EF622C80AC53342E" modified="2016-09-07" version="1" fragment="single">IGPEGTVPVVRQYGRLPDVKAPPQTINSSFAQQIHIGKRAIGDHWYASSAQNVVNHGGSATYSLYKAYTESNADFSLLQSAVIKYNVKNPLYNDPNRVAMQTVEAGWINYPNQVSAPHLFVYYTTNGYTTSANNQGGWNRDVTGWVQVDSSIYPGVSFTPLSTRGGAQYDIKIQWLLYKGNWWLFVLDRWIGYYPASLFGANTDASKSLQVGADAINYYGEIYDSHQSLTKTDMGSGTFPDKGYGQSAYIRNMVYTDSNGQDQKYDGSKGIVVSDTNRYRMSADWSGSGSWGSYMYLGGPGAGGQIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CK44</accession>
    <name>A0A177CK44_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">FMN-dependent dehydrogenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_1216202</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG07210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037575.1">
        <property type="nucleotide sequence ID" value="XM_018182781.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CK44"/>
    <dbReference type="STRING" id="1460663.A0A177CK44"/>
    <dbReference type="GeneID" id="28766267"/>
    <dbReference type="InParanoid" id="A0A177CK44"/>
    <dbReference type="OrthoDB" id="25826at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000262">
        <property type="entry name" value="FMN-dep_DH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01070">
        <property type="entry name" value="FMN_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN-dependent dehydrogenase" evidence="3">
        <location>
            <begin position="82"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAG07210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="188" mass="20310" checksum="9181A4AFA767FF02" modified="2016-09-07" version="1">MDPHNPNRESRSTPQYGLYQRENFWKSSDEVPPFNAEPGKLEELAQKKPTQTRWYYASSTAGYSTQTPARPRTPSGWGDAASAPIGINKTCNEAGESPVARVAGDLNLSYCLSTAGSQPIEDVGAANDALAPNGKGGVRFFQLYMPHDNALTRFLLKRAINPSFTACILARHVAAGLACSQTWTSSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CKY1</accession>
    <name>A0A177CKY1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative adenosine deaminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CC84DRAFT_1258593</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG07510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037875.1">
        <property type="nucleotide sequence ID" value="XM_018184841.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CKY1"/>
    <dbReference type="STRING" id="1460663.A0A177CKY1"/>
    <dbReference type="GeneID" id="28768327"/>
    <dbReference type="InParanoid" id="A0A177CKY1"/>
    <dbReference type="OrthoDB" id="272271at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000034">
        <property type="term" value="F:adenine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006146">
        <property type="term" value="P:adenine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043103">
        <property type="term" value="P:hypoxanthine salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001365">
        <property type="entry name" value="A_deaminase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006330">
        <property type="entry name" value="Ado/ade_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01430">
        <property type="entry name" value="aden_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43114">
        <property type="entry name" value="ADENINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43114:SF7">
        <property type="entry name" value="ADENOSINE DEAMINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00962">
        <property type="entry name" value="A_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Adenosine deaminase" evidence="4">
        <location>
            <begin position="14"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAG07510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="363" mass="41133" checksum="DC74C68CC6C10C33" modified="2016-09-07" version="1">MDGLEISPFVKGLPKVELHVHIEGTLTPALRWKLAHQNNVKLPYATYEELLDSYAVTYNHRKEVNGDDGRPTFLEAYFAGCQVLVTEDDFYELSMEYFSRCVEMNVRYCEPFFDTQAHTERGISVPTILNGYLRAQKDGLEKYGVRSNWIFCFLRDRPLREGLDAYAAARSWGRLADGTGKGLFHAVGLAANEFEKPPMLFEAGFRMAKEDGLHVTLHCDVDQKDAADHVRQAIFEVCDGQGTERIDHGLNALDRPDLVPALKQRGIGLTLCPHAYHRRQSTETLFPKITSLIRAGVKLCINSDDPTYMHNVWIDGNMQKVYTYCGLSKAEMVTLVKNGIEMSWADEKIKMGLMEELDRLDVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CL56</accession>
    <name>A0A177CL56_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chaps-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_563466</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038608.1">
        <property type="nucleotide sequence ID" value="XM_018186704.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CL56"/>
    <dbReference type="FunCoup" id="A0A177CL56">
        <property type="interactions" value="98"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CL56"/>
    <dbReference type="GeneID" id="28770190"/>
    <dbReference type="InParanoid" id="A0A177CL56"/>
    <dbReference type="OrthoDB" id="434695at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034044">
        <property type="term" value="C:exomer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043001">
        <property type="term" value="P:Golgi to plasma membrane protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006896">
        <property type="term" value="P:Golgi to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000146">
        <property type="entry name" value="Clathrin-coated vesiclec protein (Bud7)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000149">
        <property type="entry name" value="Clathrin-coated vesiclec protein (Bud7)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015374">
        <property type="entry name" value="ChAPs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31975">
        <property type="entry name" value="BUD SITE SELECTION PROTEIN 7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31975:SF1">
        <property type="entry name" value="BUD SITE SELECTION PROTEIN 7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09295">
        <property type="entry name" value="ChAPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="422"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="429"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="454"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="465"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="511"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG08243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="693" mass="78083" checksum="BAC4850BE8E6D68A" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2023-06-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CM71</accession>
    <name>A0A177CM71_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_534191</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038407.1">
        <property type="nucleotide sequence ID" value="XM_018186652.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CM71"/>
    <dbReference type="GeneID" id="28770138"/>
    <dbReference type="InParanoid" id="A0A177CM71"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG08042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="91" mass="10491" checksum="E3A153480D0116B5" modified="2016-09-07" version="1">MEPFAYMPASGLSRHSTCGFVKLQSCQRASFMWAHRRFTTLVPAILCTIIRLYDYTWFGLGVCKVVIRLCGTYGRMGRRRELDNFSRSGDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CM93</accession>
    <name>A0A177CM93_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CC84DRAFT_525565</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Involved in pre-mRNA splicing. Facilitates the cooperative formation of U2/U6 helix II in association with stem II in the spliceosome. Binds to RNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLT11 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG07980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038345.1">
        <property type="nucleotide sequence ID" value="XM_018186632.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CM93"/>
    <dbReference type="STRING" id="1460663.A0A177CM93"/>
    <dbReference type="GeneID" id="28770118"/>
    <dbReference type="InParanoid" id="A0A177CM93"/>
    <dbReference type="OrthoDB" id="10259600at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071006">
        <property type="term" value="C:U2-type catalytic step 1 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071007">
        <property type="term" value="C:U2-type catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036002">
        <property type="term" value="F:pre-mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017070">
        <property type="term" value="F:U6 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12265">
        <property type="entry name" value="RRM_SLT11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000396">
        <property type="entry name" value="Putative Pre-mRNA-splicing factor slt11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039171">
        <property type="entry name" value="Cwc2/Slt11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034356">
        <property type="entry name" value="Slt11_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048995">
        <property type="entry name" value="STL11/RBM22-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14089">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR RBM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14089:SF6">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR RBM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21369">
        <property type="entry name" value="STL11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="RRM" evidence="11">
        <location>
            <begin position="234"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="152"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="173"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="200"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OAG07980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="371" mass="40729" checksum="373544B6C1475D48" modified="2016-09-07" version="1">MPPQIKQDLNRSGWETTDFPSVCERCLPDNPYVQMLKEDYGAECKICTRPFTIFRWKADRTARQKRTNLCLTCARLKNCCQCCMLDLSFGLPIVVRDAALKMVAPGPQSDINRQYYAQEHEREIEEGRGAVEAYDKTDEKARDLLKRLAQSEPYYKKQRRQEAEGEGAQKALPAPGGESSSAGGHTPGPIRTRDSRGPASGRGGMRPGRGGRVGGAPAAPSPEDWLPPRDPNVASLFVTGVEDDLPEHEIRTHFAQYGKLRSVVCSHRAHCAYINYVQRKDAETAAETLKGKVVIKGCPMKVTWGKPKQLDSLDQNVRMMYAKEGRQASGSARRAQAAIEAAPEASLDSLAAIAPPPGADDEVNYASLAGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CMI9</accession>
    <name>A0A177CMI9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein RER1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_1162154</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in the retrieval of endoplasmic reticulum membrane proteins from the early Golgi compartment.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the RER1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038527.1">
        <property type="nucleotide sequence ID" value="XM_018177922.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CMI9"/>
    <dbReference type="FunCoup" id="A0A177CMI9">
        <property type="interactions" value="842"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CMI9"/>
    <dbReference type="GeneID" id="28761408"/>
    <dbReference type="InParanoid" id="A0A177CMI9"/>
    <dbReference type="OrthoDB" id="448250at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006621">
        <property type="term" value="P:protein retention in ER lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004932">
        <property type="entry name" value="Rer1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10743">
        <property type="entry name" value="PROTEIN RER1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10743:SF0">
        <property type="entry name" value="PROTEIN RER1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03248">
        <property type="entry name" value="Rer1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016013">
        <property type="entry name" value="AtER_Rer1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="37"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="61"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="144"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR016013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAG08162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="188" mass="21754" checksum="3D1F98D2A0D8BC88" modified="2016-09-07" version="1">MDAPEPDTPFSAVTAQTTKYGRIFQAYLDKSTPFTTYRWVGTGVLFVLFALRIFIAEGWYIVAYSLGIYLLNLFLAFISPKFDPSLEQDEGMEDGNAGGLPTKADDEFRPFVRRLPEFKFWYSTTKAISIGFLCSWFEVFNLPVFWPVLVVYWLILFGLTMRRQIQHMIKYRYVPFTVGKTRYPGAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CMS6</accession>
    <name>A0A177CMS6_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Thioredoxin-like fold domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1162667</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039188.1">
        <property type="nucleotide sequence ID" value="XM_018178054.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CMS6"/>
    <dbReference type="STRING" id="1460663.A0A177CMS6"/>
    <dbReference type="GeneID" id="28761540"/>
    <dbReference type="InParanoid" id="A0A177CMS6"/>
    <dbReference type="OrthoDB" id="37297at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012336">
        <property type="entry name" value="Thioredoxin-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33875:SF2">
        <property type="entry name" value="ACR183CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33875">
        <property type="entry name" value="OS09G0542200 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13462">
        <property type="entry name" value="Thioredoxin_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin-like fold" evidence="1">
        <location>
            <begin position="19"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG08823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="210" mass="23519" checksum="74314E8D95F9115E" modified="2016-09-07" version="1">MALAPRFAGQKLASSSIQPKAVHTLELYLDYVCPFSAKLFKTVYSSPLRDALLQKYGDRVVTIFRQQIQPWHPSSTLTHEAGYAVLKLSPEKFYAFSEKLFEQQKEFFDVSVVNETRNETYKRLAKIAGEVGVDEGKVFDMLKISDKPGEDGSLNSGNGVTDAVKVQVKANRLVGVHVTPTAVFDGVVINDISSSWTKEQWEEWLEKNVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CMZ0</accession>
    <name>A0A177CMZ0_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1086658</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039021.1">
        <property type="nucleotide sequence ID" value="XM_018174171.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CMZ0"/>
    <dbReference type="STRING" id="1460663.A0A177CMZ0"/>
    <dbReference type="GeneID" id="28757657"/>
    <dbReference type="InParanoid" id="A0A177CMZ0"/>
    <dbReference type="OrthoDB" id="2316594at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008571">
        <property type="entry name" value="HerA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42957">
        <property type="entry name" value="HELICASE MJ1565-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42957:SF1">
        <property type="entry name" value="HELICASE MJ1565-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG08656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="517" mass="57329" checksum="EBA27369B4269BE0" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CN35</accession>
    <name>A0A177CN35_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">60S ribosomal protein L13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CC84DRAFT_1162354</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL13 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038757.1">
        <property type="nucleotide sequence ID" value="XM_018177969.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CN35"/>
    <dbReference type="FunCoup" id="A0A177CN35">
        <property type="interactions" value="984"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CN35"/>
    <dbReference type="GeneID" id="28761455"/>
    <dbReference type="InParanoid" id="A0A177CN35"/>
    <dbReference type="OrthoDB" id="10264538at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030684">
        <property type="term" value="C:preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00499">
        <property type="entry name" value="Ribosomal_eL13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001380">
        <property type="entry name" value="Ribosomal_eL13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018256">
        <property type="entry name" value="Ribosomal_eL13_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11722">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11722:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01294">
        <property type="entry name" value="Ribosomal_L13e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01104">
        <property type="entry name" value="RIBOSOMAL_L13E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="192"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAG08392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="214" mass="24297" checksum="03493052307C8DAE" modified="2016-09-07" version="1">MAIKHNQQIQKNHFHKDWQRYVRVHFDQAGKKKSRRDARAAKITKVAPRPVDKLRPVVRCPTVKYNRRVRPGRGFSLAELKAAGIPRKLAPTIGISVDPRRQNLSEESLKANVERLQEYRKKLILFPRRNGKTKSGDASAEDVKAAKKGETVTSTSSVFPIVNKPIFEEASIGSVEATENAYRKLRDQRAEQRYAGAKEKRAKAKAEEADSKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CNX4</accession>
    <name>A0A177CNX4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transmembrane protein 135 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1194664</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038864.1">
        <property type="nucleotide sequence ID" value="XM_018181358.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CNX4"/>
    <dbReference type="GeneID" id="28764844"/>
    <dbReference type="InParanoid" id="A0A177CNX4"/>
    <dbReference type="OrthoDB" id="291792at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026749">
        <property type="entry name" value="Tmem135"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12459:SF19">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 135 N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12459">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 135-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG08499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="534" mass="60149" checksum="A98B56074B52CF31" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CPI6</accession>
    <name>A0A177CPI6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_431768</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG09216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039581.1">
        <property type="nucleotide sequence ID" value="XM_018186226.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CPI6"/>
    <dbReference type="GeneID" id="28769712"/>
    <dbReference type="InParanoid" id="A0A177CPI6"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG09216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="96" mass="11372" checksum="6F6E9147BE4763C2" modified="2016-09-07" version="1">MAATQHRTRRRNQVDLDMLMTFEVYLFVTALFVCCIPPRPVEVREAARPNLHRLTREQRHISSRRSKQMSQENETARLRRRLNEPIHLPMSKSFGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CPN9</accession>
    <name>A0A177CPN9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cytochrome P450 3A30</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CC84DRAFT_1086280</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039263.1">
        <property type="nucleotide sequence ID" value="XM_018174153.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CPN9"/>
    <dbReference type="STRING" id="1460663.A0A177CPN9"/>
    <dbReference type="GeneID" id="28757639"/>
    <dbReference type="InParanoid" id="A0A177CPN9"/>
    <dbReference type="OrthoDB" id="10029320at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF232">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0349">Heme</keyword>
    <keyword evidence="4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="460"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAG08898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="530" mass="59879" checksum="F506DE1DAAE75033" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CQ23</accession>
    <name>A0A177CQ23_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">NCS1 nucleoside transporter family protein-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CC84DRAFT_1194879</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039212.1">
        <property type="nucleotide sequence ID" value="XM_018181371.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CQ23"/>
    <dbReference type="FunCoup" id="A0A177CQ23">
        <property type="interactions" value="34"/>
    </dbReference>
    <dbReference type="GeneID" id="28764857"/>
    <dbReference type="InParanoid" id="A0A177CQ23"/>
    <dbReference type="OrthoDB" id="2018619at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015205">
        <property type="term" value="F:nucleobase transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11482">
        <property type="entry name" value="SLC-NCS1sbd_NRT1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4160.10">
        <property type="entry name" value="Hydantoin permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045225">
        <property type="entry name" value="Uracil/uridine/allantoin_perm"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30618:SF4">
        <property type="entry name" value="ALLANTOIN PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30618">
        <property type="entry name" value="NCS1 FAMILY PURINE/PYRIMIDINE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="143"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="173"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="199"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="246"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="279"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="337"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="377"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="400"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="454"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="485"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAG08847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="633" mass="70579" checksum="4F83D7E830BAE77B" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CQH6</accession>
    <name>A0A177CQH6_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glycosyltransferase family 31 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_453363</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG09774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040139.1">
        <property type="nucleotide sequence ID" value="XM_018186326.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CQH6"/>
    <dbReference type="STRING" id="1460663.A0A177CQH6"/>
    <dbReference type="GeneID" id="28769812"/>
    <dbReference type="InParanoid" id="A0A177CQH6"/>
    <dbReference type="OrthoDB" id="414175at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008058470" description="Glycosyltransferase family 31 protein" evidence="1">
        <location>
            <begin position="29"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG09774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="462" mass="53787" checksum="47D1B5E6681BA913" modified="2016-09-07" version="1">MLSNRRAIRPLRFLVLLISLCFCFWVSGFPRTYDDDELPLSQRRPTPGVLEPEQIIVSVKTTTPNAWSELPPLLVLTDSAYHDSLLLMGDLRLNVGPFTVEDVLDRYTDSFVQDNPDMERYRATLEFADSSVSFAELTERDPRKEKEVLAKLDKYKMLRWVERTWLLRPERPWYVLTEPNVHLVRPNLLSWLGTYDPDGYHFFATPSAPEAAHTIVLSRGVMKAIMVDRPDLIPYYDNNIRGHKNAFEVLATVLLSTLNVTATMVWPEISHYSPATAPYGPGLWCDHVITMSNMPTDLMNELWRFEHERRNWPNEDALCFADLWFRFMQPENLDPRDDWDNLSSGTGYEQWNILFDRKHEHHSEKSSGRAKPGEASWEACRDSCSENDFCVQWSYSSVPMPNDNENGDTRCHLSRSMKFGQHVAPQLVDRFGEKATLAWKSGWEKERFQSWARQQRCKEQQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CQX5</accession>
    <name>A0A177CQX5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">CBS-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CC84DRAFT_1212804</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 5'-AMP-activated protein kinase gamma subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG09358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039723.1">
        <property type="nucleotide sequence ID" value="XM_018182480.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CQX5"/>
    <dbReference type="FunCoup" id="A0A177CQX5">
        <property type="interactions" value="434"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CQX5"/>
    <dbReference type="GeneID" id="28765966"/>
    <dbReference type="InParanoid" id="A0A177CQX5"/>
    <dbReference type="OrthoDB" id="286637at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005641">
        <property type="term" value="C:nuclear envelope lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031588">
        <property type="term" value="C:nucleotide-activated protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016208">
        <property type="term" value="F:AMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004679">
        <property type="term" value="F:AMP-activated protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043539">
        <property type="term" value="F:protein serine/threonine kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030447">
        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007031">
        <property type="term" value="P:peroxisome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045722">
        <property type="term" value="P:positive regulation of gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000217">
        <property type="term" value="P:regulation of invasive growth in response to glucose limitation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd04618">
        <property type="entry name" value="CBS_euAMPK_gamma-like_repeat1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04641">
        <property type="entry name" value="CBS_euAMPK_gamma-like_repeat2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050511">
        <property type="entry name" value="AMPK_gamma/SDS23_families"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13780">
        <property type="entry name" value="AMP-ACTIVATED PROTEIN KINASE, GAMMA REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13780:SF35">
        <property type="entry name" value="LD22662P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0129">CBS domain</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="CBS" evidence="6">
        <location>
            <begin position="162"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="6">
        <location>
            <begin position="238"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="6">
        <location>
            <begin position="312"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAG09358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="370" mass="41618" checksum="AB2E154855923F93" modified="2016-09-07" version="1">MSGADTADSATSAPPNPPSAANDVLQPHERPTFVTPRDFLEQGRPVLPPRALTAVDKEQLDGLRTIRAFLKVRTSYDVLPLSYRLIVLDTALLVKKSLNILIQNGIVSAPLWDSKTSTFAGLLTTSDYLNVIQYYWQNPDALARVDQFRLNSLRDIEKSLGVTPIETVSIHPERPLYEACRKMLEARARRIPIVDIDDETRRTTVVSVITQYRLLKFVAVNVKETQKLRKPLKELVKVGTYDNLATAYMDTPVMDVIHMLVKKSISSVPIIDKQGTVLNVFESVDVITLIKGGIYDDLNLTVGDALLKRSEDFPGIYTCSMQDQLSTIYDTIRRSRVHRFIVIDDDNKLKGVLTLSDILEYTLLEGEENE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CQZ5</accession>
    <name>A0A177CQZ5_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">rhamnogalacturonan endolyase</fullName>
            <ecNumber evidence="4">4.2.2.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CC84DRAFT_1255387</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endotype eliminative cleavage of L-alpha-rhamnopyranosyl-(1-&gt;4)-alpha-D-galactopyranosyluronic acid bonds of rhamnogalacturonan I domains in ramified hairy regions of pectin leaving L-rhamnopyranose at the reducing end and 4-deoxy-4,5-unsaturated D-galactopyranosyluronic acid at the non-reducing end.</text>
            <dbReference type="EC" id="4.2.2.23"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the polysaccharide lyase 4 family.</text>
    </comment>
    <dbReference type="EC" id="4.2.2.23" evidence="4"/>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG09310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039675.1">
        <property type="nucleotide sequence ID" value="XM_018184536.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CQZ5"/>
    <dbReference type="GeneID" id="28768022"/>
    <dbReference type="InParanoid" id="A0A177CQZ5"/>
    <dbReference type="OrthoDB" id="2130367at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102210">
        <property type="term" value="F:rhamnogalacturonan endolyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd10316">
        <property type="entry name" value="RGL4_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10320">
        <property type="entry name" value="RGL4_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1120">
        <property type="entry name" value="Carboxypeptidase-like, regulatory domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013784">
        <property type="entry name" value="Carb-bd-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051850">
        <property type="entry name" value="Polysacch_Lyase_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029413">
        <property type="entry name" value="RG-lyase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029411">
        <property type="entry name" value="RG-lyase_III"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32018:SF9">
        <property type="entry name" value="RHAMNOGALACTURONATE LYASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32018">
        <property type="entry name" value="RHAMNOGALACTURONATE LYASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14683">
        <property type="entry name" value="CBM-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14686">
        <property type="entry name" value="fn3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49452">
        <property type="entry name" value="Starch-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 14" id="KW-0456">Lyase</keyword>
    <keyword evidence="10" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008058488" description="rhamnogalacturonan endolyase" evidence="11">
        <location>
            <begin position="21"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="domain" description="Rhamnogalacturonan lyase" evidence="13">
        <location>
            <begin position="382"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="Rhamnogalacturonan lyase" evidence="12">
        <location>
            <begin position="472"/>
            <end position="689"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF14683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF14686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OAG09310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="692" mass="76957" checksum="95442243BF4270D9" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CR56</accession>
    <name>A0A177CR56_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fungal-specific transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_459240</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040368.1">
        <property type="nucleotide sequence ID" value="XM_018186361.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CR56"/>
    <dbReference type="STRING" id="1460663.A0A177CR56"/>
    <dbReference type="GeneID" id="28769847"/>
    <dbReference type="InParanoid" id="A0A177CR56"/>
    <dbReference type="OrthoDB" id="4158087at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540">
        <property type="entry name" value="TRANSCRIPTION FACTOR (ACR-2), PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540:SF9">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG10003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="490" mass="56702" checksum="44B426502A355E15" modified="2016-09-07" version="1">MRYALGIHHPYSRRTESIVRRFIRVYYLEFNMQQTFCFVNGTHVDKLTKKRMRRHVMMGKNAGRTIKRKSRIDVPPHQVANMTAVSSVALRQEPVFDRFAYLDNYKPDNIYNNVLSGLSFPVKITPQFAEIVSNFFLFIAHKLYPVALGISIEKSKYTLLSILMSDKAAFYCNIALMQACNELFLGDGEKSPAAIYHLSNSLKYVRERLESEEALSDSTMGMVMSLITQEQCRQQHKAARIHMDGLAQMIKLRGGLESLEGCLPILLKACKTDLMYALQCEDTPRFHRSHMPQIISTLHSLDLPFNREAARKQVQHPNLDSALLDVLIDVICATTLFNDLHSTRKVDLYFFQEILVDYCYRLLAIPHLHSPQTLEDAYHVGLKIFMMSLFLQVGSQRIMNYDNVTERLKMVLESDILDGENELRFWLLMMGGVWVADNEDVEWLVLVKHAQTRKMGLGSWSEAKQIVEMWPWIGRLHDAPGKLFWDRTRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CS81</accession>
    <name>A0A177CS81_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">STAS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CC84DRAFT_1202387</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG09740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040105.1">
        <property type="nucleotide sequence ID" value="XM_018181772.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CS81"/>
    <dbReference type="STRING" id="1460663.A0A177CS81"/>
    <dbReference type="GeneID" id="28765258"/>
    <dbReference type="InParanoid" id="A0A177CS81"/>
    <dbReference type="OrthoDB" id="288203at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07042">
        <property type="entry name" value="STAS_SulP_like_sulfate_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="entry name" value="STAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011547">
        <property type="entry name" value="SLC26A/SulP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001902">
        <property type="entry name" value="SLC26A/SulP_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00815">
        <property type="entry name" value="sulP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11814">
        <property type="entry name" value="SULFATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01740">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00916">
        <property type="entry name" value="Sulfate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SpoIIaa-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="61"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="137"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="169"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="212"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="243"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="339"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="374"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="396"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="450"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="domain" description="STAS" evidence="6">
        <location>
            <begin position="493"/>
            <end position="652"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAG09740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="670" mass="72932" checksum="DF7E846FF8C759C4" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CSB1</accession>
    <name>A0A177CSB1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">40S ribosomal protein S4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CC84DRAFT_1256259</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the eukaryotic ribosomal protein eS4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040789.1">
        <property type="nucleotide sequence ID" value="XM_018184606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CSB1"/>
    <dbReference type="FunCoup" id="A0A177CSB1">
        <property type="interactions" value="1125"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CSB1"/>
    <dbReference type="GeneID" id="28768092"/>
    <dbReference type="InParanoid" id="A0A177CSB1"/>
    <dbReference type="OrthoDB" id="1109245at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06087">
        <property type="entry name" value="KOW_RPS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000005">
        <property type="entry name" value="40S ribosomal protein S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.740:FF:000001">
        <property type="entry name" value="40S ribosomal protein S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.290.10:FF:000002">
        <property type="entry name" value="40S ribosomal protein S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="entry name" value="RNA-binding S4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00485">
        <property type="entry name" value="Ribosomal_eS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000876">
        <property type="entry name" value="Ribosomal_eS4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032277">
        <property type="entry name" value="Ribosomal_eS4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013845">
        <property type="entry name" value="Ribosomal_eS4_central_region"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038237">
        <property type="entry name" value="Ribosomal_eS4_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041982">
        <property type="entry name" value="Ribosomal_eS4_KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013843">
        <property type="entry name" value="Ribosomal_eS4_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018199">
        <property type="entry name" value="Ribosomal_eS4_N_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11581">
        <property type="entry name" value="30S/40S RIBOSOMAL PROTEIN S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11581:SF0">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN ES4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16121">
        <property type="entry name" value="40S_S4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00467">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00900">
        <property type="entry name" value="Ribosomal_S4e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08071">
        <property type="entry name" value="RS4NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002116">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00528">
        <property type="entry name" value="RIBOSOMAL_S4E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50889">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 9" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6 7" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="RNA-binding S4" evidence="8">
        <location>
            <begin position="42"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR002116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAG10424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="262" mass="29294" checksum="3178F11D13E1ABA0" modified="2016-09-07" version="1">MGRGPKKHQKRLSAPSHWLLDKLSGAYAPKASPGPHKLRDSLPLVIFLRNRLKYALNAREVKSILMQRLVKVDGKVRTDSTFPAGLMDVITIDKTGENFRLVFDTKGRYTVHRITGEEAAYKLGKVKRVQLGRGGIPYCVTHDARTIRYPDPAIKVNDTVKIDLATGKITDFIKFDTAVIVMITGGHNMGRVGVVTHRERHDGGFNIVHVKDAVDNEFTTRESNVFVIGREKPWVSLPKGKGVKLSISEERDRRRAQALAGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CSS0</accession>
    <name>A0A177CSS0_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">cutinase</fullName>
            <ecNumber evidence="2">3.1.1.74</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CC84DRAFT_1213203</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>cutin + H2O = cutin monomers.</text>
            <dbReference type="EC" id="3.1.1.74"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the cutinase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.74" evidence="2"/>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG09817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040182.1">
        <property type="nucleotide sequence ID" value="XM_018182511.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CSS0"/>
    <dbReference type="GeneID" id="28765997"/>
    <dbReference type="InParanoid" id="A0A177CSS0"/>
    <dbReference type="OrthoDB" id="2975078at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050525">
        <property type="term" value="F:cutinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000675">
        <property type="entry name" value="Cutinase/axe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011150">
        <property type="entry name" value="Cutinase_monf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48250:SF2">
        <property type="entry name" value="CUTINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48250">
        <property type="entry name" value="CUTINASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01083">
        <property type="entry name" value="Cutinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01110">
        <property type="entry name" value="Cutinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008058547" description="cutinase" evidence="9">
        <location>
            <begin position="19"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="46"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="184"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00034045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR611150-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAG09817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="292" mass="31588" checksum="E71D0EC049626E45" modified="2016-09-07" version="1">MKYLLAFTLPALLPLAESTPHPLRRTTYGPQTSSHIDEVLAGSRPCSSSAVVIGRETWAPGNIGVFWGARFRDELVDAFDGDVDVQGIHREDYPANLVDYHIGGSDTGADSCARMVDEYVEKCPGARVFVTGYSQGSLVAYKCVNRVSAAARAQIKALVVFGSEERLMDDVQPVPKGIILKNYCVENTTAPDVVCTETLTSGIELPNSVGDVVAQLKETVASLKNVVTNEDQLKEVATIPALLIRDLPATLPWIAKDVAQGKIRRWMILPPHLLYGFNGMTTDAAAWMAGVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CSW4</accession>
    <name>A0A177CSW4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">aspartyl aminopeptidase</fullName>
            <ecNumber evidence="4">3.4.11.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CC84DRAFT_1161523</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of an N-terminal aspartate or glutamate from a peptide, with a preference for aspartate.</text>
            <dbReference type="EC" id="3.4.11.21"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the peptidase M18 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.21" evidence="4"/>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040990.1">
        <property type="nucleotide sequence ID" value="XM_018177760.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CSW4"/>
    <dbReference type="FunCoup" id="A0A177CSW4">
        <property type="interactions" value="611"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CSW4"/>
    <dbReference type="GeneID" id="28761246"/>
    <dbReference type="InParanoid" id="A0A177CSW4"/>
    <dbReference type="OrthoDB" id="9880441at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05658">
        <property type="entry name" value="M18_DAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.250.10:FF:000001">
        <property type="entry name" value="Aspartyl aminopeptidase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.250.10">
        <property type="entry name" value="Aminopeptidase i, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001948">
        <property type="entry name" value="Peptidase_M18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023358">
        <property type="entry name" value="Peptidase_M18_dom2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002759">
        <property type="entry name" value="PRK02813.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28570">
        <property type="entry name" value="ASPARTYL AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28570:SF3">
        <property type="entry name" value="ASPARTYL AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02127">
        <property type="entry name" value="Peptidase_M18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00932">
        <property type="entry name" value="AMINO1PTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101821">
        <property type="entry name" value="Aminopeptidase/glucanase lid domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11 12" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="8 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6 11" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 11" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OAG10625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="506" mass="55367" checksum="567537B411B6481A" modified="2016-09-07" version="1">MSTKPSLAAAEDFLSFVNDSPTPFHAVKSSKDRLEKAGFKQIKERDSWASALQPGGKYYLTRNGSSIVAFAIGKNWKAGNPIGMIGAHTDSCCLRLKPVSKRQSDGFLQVACETYGGGLWHTWFDRDLSLAGRLMVRTEQGNIESRLVKVERPILRVPTLAIHLDRQEDFKFNKEAQLFPIAGLVAAELNRQGKSAEAAKEEESKESPVEPLAAPMQRHHTYLVEIVAEEAGVDPSDIVDFELVLYDTQKAVVGGLNNELIFSARLDNLMMSYCSVEGLIQSLASSSSLEKDSTIRLIALFDHEEIGSRTAQGADSNLLPAVIRRLSVLPPSEGSHSDKSYDKLDVDSATVYEQTLATSFLISADMAHSVHPNYPAKYESQHRPEMNKGTVIKINANARYATNSPGIVLVQEAARLAKRGSASPASVKEGVPLQLFVVRNDSSCGSTIGPMLSAAMGARTLDLGNPQLSMHSIRETGGAHDVEYAINLFDSFFEHFEDLEKKIIVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CU56</accession>
    <name>A0A177CU56_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RNA-dependent RNA polymerase</fullName>
            <ecNumber evidence="8">2.7.7.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CC84DRAFT_1138943</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.48"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the RdRP family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.48" evidence="8"/>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040785.1">
        <property type="nucleotide sequence ID" value="XM_018176214.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CU56"/>
    <dbReference type="STRING" id="1460663.A0A177CU56"/>
    <dbReference type="GeneID" id="28759700"/>
    <dbReference type="InParanoid" id="A0A177CU56"/>
    <dbReference type="OrthoDB" id="6513042at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031380">
        <property type="term" value="C:nuclear RNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003968">
        <property type="term" value="F:RNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030422">
        <property type="term" value="P:siRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007855">
        <property type="entry name" value="RDRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058752">
        <property type="entry name" value="RDRP_C_head"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057596">
        <property type="entry name" value="RDRP_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058751">
        <property type="entry name" value="RDRP_helical"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23079">
        <property type="entry name" value="RNA-DEPENDENT RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23079:SF55">
        <property type="entry name" value="RNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05183">
        <property type="entry name" value="RdRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26253">
        <property type="entry name" value="RdRP_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26252">
        <property type="entry name" value="RdRP_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 8" id="KW-0696">RNA-directed RNA polymerase</keyword>
    <keyword evidence="6" id="KW-0943">RNA-mediated gene silencing</keyword>
    <keyword evidence="3 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RDRP helical" evidence="11">
        <location>
            <begin position="252"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="RDRP core" evidence="10">
        <location>
            <begin position="337"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="domain" description="RDRP C-terminal head" evidence="12">
        <location>
            <begin position="931"/>
            <end position="1065"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1064"/>
            <end position="1090"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="113"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF26252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF26253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OAG10420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="1118" mass="126507" checksum="7653C779BFB6DAAD" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CUK5</accession>
    <name>A0A177CUK5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Major facilitator superfamily transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CC84DRAFT_1223960</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG11203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041568.1">
        <property type="nucleotide sequence ID" value="XM_018183533.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CUK5"/>
    <dbReference type="STRING" id="1460663.A0A177CUK5"/>
    <dbReference type="GeneID" id="28767019"/>
    <dbReference type="InParanoid" id="A0A177CUK5"/>
    <dbReference type="OrthoDB" id="5215911at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF50">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G00430)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="97"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="121"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="182"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="209"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="322"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="367"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="402"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="429"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="466"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="495"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="54"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAG11203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="540" mass="59332" checksum="1B4FB2289F6A7F7A" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CUP4</accession>
    <name>A0A177CUP4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1158831</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG11264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041629.1">
        <property type="nucleotide sequence ID" value="XM_018177078.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CUP4"/>
    <dbReference type="STRING" id="1460663.A0A177CUP4"/>
    <dbReference type="GeneID" id="28760564"/>
    <dbReference type="InParanoid" id="A0A177CUP4"/>
    <dbReference type="OrthoDB" id="4521980at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG11264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="123" mass="13549" checksum="4A13AD1AB4B38639" modified="2016-09-07" version="1">MPATVLGPQVKPIANPTSTEWNLAIKDTDYDSVLKGFKPQQMEDRWVCVADGPDAHGNTILHAARSWTSEEQVSLTIEAGKDDVGPKIGKLTWDISEYDSEQEAKELAVNICRHILGCELENA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CV90</accession>
    <name>A0A177CV90_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1158985</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG11443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041808.1">
        <property type="nucleotide sequence ID" value="XM_018177110.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CV90"/>
    <dbReference type="GeneID" id="28760596"/>
    <dbReference type="InParanoid" id="A0A177CV90"/>
    <dbReference type="OrthoDB" id="5131270at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG11443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="291" mass="33089" checksum="F5E2B7C8917D07DC" modified="2016-09-07" version="1">MNLEGSIPRLRLSYTYWAPSNLRNTPTRIPLGRQTSMLALLLLLCFPLASPWTIDVHPDLSYPARWTAAPGDRYMSRNGTFLSPGYLNSCLNERVPQNVTRSKFHVFNGRAIFDLVNATQGNPTNESFHLDVYLPHLYYKWVDGPGGSEYNEGPKGKYKMGQTMWRYHYWQNFPKQGRCYLPLNMTEMVVDEDGKALRSEDLVGLNATLTFELCDARNYRTFEQVDQCAYVTLTDEDVQPVEDIPHCDSYNPISELAKNSQSSPPQSPGKKLERGRLIGLPGLVIALWMAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CVM4</accession>
    <name>A0A177CVM4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1253768</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG11271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041636.1">
        <property type="nucleotide sequence ID" value="XM_018184401.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CVM4"/>
    <dbReference type="GeneID" id="28767887"/>
    <dbReference type="InParanoid" id="A0A177CVM4"/>
    <dbReference type="OrthoDB" id="3860394at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008058653" evidence="2">
        <location>
            <begin position="20"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="100"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG11271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="289" mass="31017" checksum="5B3E5FCA40E5E359" modified="2016-09-07" version="1">MSSRLLTALKSMMFTGVILLPTAFPHAVQDLVDLKTVIDATAATIDAAPNNSSWGFFSPASPAGSLGTADLIANISTTILRAKYLLNVDRTAWTTIPDNTTALNNTANPTPTEIRQASTPTPPPSSNISLDAPYVDYVSSIPSLSNALVDLGRAWHKELNSPVSEAIGALQEAITQFSTSMLEGDLLNSTSILRTIRASSSLESAQVAWSRVLNLPGAAGTKKKRGEVEVKRPPLPDGQFYTHKDLWGRGSGAVPRQAKVENDDSSKASTVEATWSEWRIEKIARRFVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CWL2</accession>
    <name>A0A177CWL2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">C6 zinc finger domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_1182763</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG11954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042319.1">
        <property type="nucleotide sequence ID" value="XM_018180645.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CWL2"/>
    <dbReference type="GeneID" id="28764131"/>
    <dbReference type="InParanoid" id="A0A177CWL2"/>
    <dbReference type="OrthoDB" id="6133115at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053181">
        <property type="entry name" value="EcdB-like_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47785:SF6">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47785">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="3">
        <location>
            <begin position="167"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="19"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="28"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="44"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAG11954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="588" mass="66226" checksum="6FC7A80B8993A146" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CWT8</accession>
    <name>A0A177CWT8_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CC84DRAFT_1192330</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the alkB family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG11983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042348.1">
        <property type="nucleotide sequence ID" value="XM_018181243.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CWT8"/>
    <dbReference type="STRING" id="1460663.A0A177CWT8"/>
    <dbReference type="GeneID" id="28764729"/>
    <dbReference type="InParanoid" id="A0A177CWT8"/>
    <dbReference type="OrthoDB" id="412814at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.590">
        <property type="entry name" value="Alpha-ketoglutarate-dependent dioxygenase AlkB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027450">
        <property type="entry name" value="AlkB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037151">
        <property type="entry name" value="AlkB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032862">
        <property type="entry name" value="ALKBH6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46030">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE ALKB HOMOLOG 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46030:SF1">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE ALKB HOMOLOG 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13532">
        <property type="entry name" value="2OG-FeII_Oxy_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="8">
        <location>
            <begin position="97"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAG11983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="250" mass="27139" checksum="652936D60258874B" modified="2016-09-07" version="1">MDPINGREGLEAFRIASLPPEFYYIPNFITAEEEASILDKIPANRWITLSHRRLQAHPSTLTKNNTLLGAPLPPYLLTPIAERFKQLGIFDDTPHRQPNHVLINEYKKGEGIMPHEDGAAYAPVVATVSLGGSLCLELTVKSSVPEGESAPEEEKGGEKGEYAVPARILQEPRSLLVTTGAAYADLLHGISPVEVDEGLGEETVANWALLGDSSAFEGGRNERGTRVSLTYRDVLRVSGAASKVLGMGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CY07</accession>
    <name>A0A177CY07_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_1079376</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042810.1">
        <property type="nucleotide sequence ID" value="XM_018173845.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CY07"/>
    <dbReference type="GeneID" id="28757331"/>
    <dbReference type="InParanoid" id="A0A177CY07"/>
    <dbReference type="OrthoDB" id="6132182at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000065">
        <property type="entry name" value="Putative MFS pantothenate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF28">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="189"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="221"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="290"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="327"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="356"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="385"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="419"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="453"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAG12445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="515" mass="58960" checksum="ABCFA5FF1BA7F703" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CZ12</accession>
    <name>A0A177CZ12_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosomal protein L15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CC84DRAFT_1254288</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL15 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG11919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042284.1">
        <property type="nucleotide sequence ID" value="XM_018184448.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CZ12"/>
    <dbReference type="FunCoup" id="A0A177CZ12">
        <property type="interactions" value="1271"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CZ12"/>
    <dbReference type="GeneID" id="28767934"/>
    <dbReference type="InParanoid" id="A0A177CZ12"/>
    <dbReference type="OrthoDB" id="10255148at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1120.10:FF:000001">
        <property type="entry name" value="Ribosomal protein L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1120.10">
        <property type="entry name" value="Ribosomal protein l15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024794">
        <property type="entry name" value="Rbsml_eL15_core_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000439">
        <property type="entry name" value="Ribosomal_eL15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020925">
        <property type="entry name" value="Ribosomal_eL15_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012678">
        <property type="entry name" value="Ribosomal_uL23/eL15/eS24_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003269">
        <property type="entry name" value="PRK04243.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11847:SF4">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11847">
        <property type="entry name" value="RIBOSOMAL PROTEIN L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00827">
        <property type="entry name" value="Ribosomal_L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01384">
        <property type="entry name" value="Ribosomal_L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54189">
        <property type="entry name" value="Ribosomal proteins S24e, L23 and L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01194">
        <property type="entry name" value="RIBOSOMAL_L15E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="161"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAG11919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="203" mass="24008" checksum="703E9AF4A9FB12C1" modified="2016-09-07" version="1">MGALKYVEELQKKKQSDMMRFLMRVRCWELRQLKVIHRASRPSRPDKARRLGYKAKQGYVIYRVRVRRGGRKRPAPKGATYGKPTNQGINQLKYQRSLKSTAEERVGRRCANLRVLNSYWINQDSTYKYYEVILVDPSHKAIRRDARINWIVNPVHKHRESRGLTATGKKSRGLGKGHGYNKTTAGRRKTWKRHNTLSLWRYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CZF2</accession>
    <name>A0A177CZF2_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CC84DRAFT_1254888</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018043051.1">
        <property type="nucleotide sequence ID" value="XM_018184494.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CZF2"/>
    <dbReference type="STRING" id="1460663.A0A177CZF2"/>
    <dbReference type="GeneID" id="28767980"/>
    <dbReference type="InParanoid" id="A0A177CZF2"/>
    <dbReference type="OrthoDB" id="294730at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000039">
        <property type="entry name" value="Neutral amino acid transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF20">
        <property type="entry name" value="AMINO ACID TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="85"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="113"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="156"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="187"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="220"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="258"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="305"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="347"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="389"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="419"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="461"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="8">
        <location>
            <begin position="78"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAG12686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="509" mass="55872" checksum="A18EF2913970D17F" modified="2016-09-07" version="1">MALGFGSKPERADSPSNDTKAADELFNKDAENGGLEKQRQGSRIEGPARRDIDSSEEESITVGKQIELEAGNAIQYRTCSWQKTAALLFSEYICLAIMSFPWSYSILGLVPGLILTCVIAALVLYTSLICWEFCMRHPEIRDVCDLGQMIFYNHRWAFWFTAVMFILNNTFIQGLHCLVGAKYLNTMTGHGICTIGFSAIVAVVSFVCSLPRTFGTLSKGATASALFTFISVLLATIFSGIMDHPKGWPAETGPIDPIVLAVPAAGTTFVAGMSAFMNISYTFIGQITLPSFIAEMKEPKDFPKALWAVTIAEVIVFGLVGSIVYAYTGTQYMTAPAFGSIGNEVMLKISFSFMIPTIIFLGVLYASVSARFIFFRFFGGTYHMGSHTVVGWAAWAAILAVLWLLAFIVAEVIPFFSDLLSLMSSLFDAFFGFIYWGVAYFRMREADYGRNYFKNRGIRGWAGFLFNVGLCCVGLLFLTGGTYATVQSIIDGYKADNFGGAFTCQDNGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177D003</accession>
    <name>A0A177D003_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1135659</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018043096.1">
        <property type="nucleotide sequence ID" value="XM_018176068.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177D003"/>
    <dbReference type="STRING" id="1460663.A0A177D003"/>
    <dbReference type="GeneID" id="28759554"/>
    <dbReference type="InParanoid" id="A0A177D003"/>
    <dbReference type="OrthoDB" id="5424797at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017956">
        <property type="entry name" value="AT_hook_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48125:SF12">
        <property type="entry name" value="AT HOOK TRANSCRIPTION FACTOR FAMILY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48125">
        <property type="entry name" value="LP07818P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00384">
        <property type="entry name" value="AT_hook"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="996"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="294"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="404"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="811"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="933"/>
            <end position="989"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1106"/>
            <end position="1148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1162"/>
            <end position="1207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="294"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="831"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="887"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="933"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="980"/>
            <end position="989"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1189"/>
            <end position="1207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG12731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="1207" mass="131450" checksum="67D84D3F6ABAAD56" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177D052</accession>
    <name>A0A177D052_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1135297</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042907.1">
        <property type="nucleotide sequence ID" value="XM_018176058.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177D052"/>
    <dbReference type="GeneID" id="28759544"/>
    <dbReference type="InParanoid" id="A0A177D052"/>
    <dbReference type="OrthoDB" id="5346713at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008058822" evidence="2">
        <location>
            <begin position="25"/>
            <end position="1136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="357"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="485"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="657"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="734"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="768"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="944"/>
            <end position="1036"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1049"/>
            <end position="1068"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="166"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="363"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="394"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="453"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="533"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="736"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="768"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="978"/>
            <end position="991"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG12542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="1136" mass="121770" checksum="F1BE0A66316E0093" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177D058</accession>
    <name>A0A177D058_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_113925</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042724.1">
        <property type="nucleotide sequence ID" value="XM_018176231.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177D058"/>
    <dbReference type="STRING" id="1460663.A0A177D058"/>
    <dbReference type="GeneID" id="28759717"/>
    <dbReference type="InParanoid" id="A0A177D058"/>
    <dbReference type="OrthoDB" id="5313079at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="204"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="235"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="274"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG12359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="584" mass="66363" checksum="1F481437EEC8D7E5" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177D1T6</accession>
    <name>A0A177D1T6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1109965</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018043364.1">
        <property type="nucleotide sequence ID" value="XM_018175237.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177D1T6"/>
    <dbReference type="STRING" id="1460663.A0A177D1T6"/>
    <dbReference type="GeneID" id="28758723"/>
    <dbReference type="InParanoid" id="A0A177D1T6"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF274">
        <property type="entry name" value="CHAIN DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G00440)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG12999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="247" mass="26189" checksum="3CAE6C9EA3B9EAD7" modified="2016-09-07" version="1">MRIFITGSSDGLGSLAAKSLVKRGHNVTLHARNSQRAEDAKAACPGADGVLIADLSSTQATKSLADDLNSKGPWDAIIHNAGVMRISSSSRGPEGLPTLFATNTLAPYMLTCLVQPPPKNLIFLSSSMHNSGDATLRDIKAASYSDSKMHNTMLAFWFAQQPAFQKTVVSSLDPGWVKTKMGGAGAGDDIGAAVEDYVKLAEGALGASGKHWYHSRERSVHRGAADKGAQEKLVKELTEISGVRLLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BT34</accession>
    <name>A0A177BT34_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_429644</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441566">
        <property type="protein sequence ID" value="OAF98562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018028928.1">
        <property type="nucleotide sequence ID" value="XM_018186210.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BT34"/>
    <dbReference type="STRING" id="1460663.A0A177BT34"/>
    <dbReference type="GeneID" id="28769696"/>
    <dbReference type="InParanoid" id="A0A177BT34"/>
    <dbReference type="OrthoDB" id="2498029at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAF98562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="131" mass="13882" checksum="BC14276260AE086C" modified="2016-09-07" version="1">MGELAHERAGRLRPPRSYEPRFGREEDDAISVTGHVTDVGELIAALQGTLDTRSARDTAVIGHSRGAIVALHWAAQSSEAIGGLAFLGIGRVAGHISAARQCMSDLASAVRSKGIAFAADVAKKWNFDEET</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BWE0</accession>
    <name>A0A177BWE0_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">1-phosphatidylinositol 4-kinase</fullName>
            <ecNumber evidence="3">2.7.1.67</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CC84DRAFT_419781</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19877"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
            <dbReference type="ChEBI" id="CHEBI:58178"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.67"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.67" evidence="3"/>
    <dbReference type="EMBL" id="KV441564">
        <property type="protein sequence ID" value="OAF98686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029052.1">
        <property type="nucleotide sequence ID" value="XM_018186152.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A177BWE0">
        <property type="interactions" value="822"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177BWE0"/>
    <dbReference type="GeneID" id="28769638"/>
    <dbReference type="InParanoid" id="A0A177BWE0"/>
    <dbReference type="OrthoDB" id="10264149at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004430">
        <property type="term" value="F:1-phosphatidylinositol 4-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061909">
        <property type="term" value="P:autophagosome-lysosome fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006995">
        <property type="term" value="P:cellular response to nitrogen starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030866">
        <property type="term" value="P:cortical actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140504">
        <property type="term" value="P:microlipophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060237">
        <property type="term" value="P:regulation of fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd05167">
        <property type="entry name" value="PI4Kc_III_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.70:FF:000011">
        <property type="entry name" value="Phosphatidylinositol 4-kinase alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1070.11:FF:000022">
        <property type="entry name" value="Phosphatidylinositol 4-kinase stt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1010.10:FF:000014">
        <property type="entry name" value="Phosphatidylinositol 4-kinase STT4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1010.10">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.70">
        <property type="entry name" value="Phosphatidylinositol 3-kinase, accessory domain (PIK)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015433">
        <property type="entry name" value="PI3/4_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001263">
        <property type="entry name" value="PI3K_accessory_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042236">
        <property type="entry name" value="PI3K_accessory_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045495">
        <property type="entry name" value="PI4K_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048:SF15">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 4-KINASE ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00613">
        <property type="entry name" value="PI3Ka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19274">
        <property type="entry name" value="PI4K_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00145">
        <property type="entry name" value="PI3Ka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00915">
        <property type="entry name" value="PI3_4_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00916">
        <property type="entry name" value="PI3_4_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51545">
        <property type="entry name" value="PIK_HELICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PIK helical" evidence="9">
        <location>
            <begin position="1362"/>
            <end position="1548"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="8">
        <location>
            <begin position="1651"/>
            <end position="1914"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAF98686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="1930" mass="215562" checksum="9E8BB473CDA7D4F2" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BWQ2</accession>
    <name>A0A177BWQ2_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Probable acetate kinase</fullName>
            <ecNumber evidence="5">2.7.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Acetokinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CC84DRAFT_1210121</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>acetate + ATP = acetyl phosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:11352"/>
            <dbReference type="ChEBI" id="CHEBI:22191"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Metabolic intermediate biosynthesis; acetyl-CoA biosynthesis; acetyl-CoA from acetate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the acetokinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.1" evidence="5"/>
    <dbReference type="EMBL" id="KV441562">
        <property type="protein sequence ID" value="OAF99181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029547.1">
        <property type="nucleotide sequence ID" value="XM_018182268.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BWQ2"/>
    <dbReference type="STRING" id="1460663.A0A177BWQ2"/>
    <dbReference type="GeneID" id="28765754"/>
    <dbReference type="InParanoid" id="A0A177BWQ2"/>
    <dbReference type="OrthoDB" id="67445at2759"/>
    <dbReference type="UniPathway" id="UPA00340">
        <property type="reaction ID" value="UER00458"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008776">
        <property type="term" value="F:acetate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006083">
        <property type="term" value="P:acetate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006085">
        <property type="term" value="P:acetyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00020">
        <property type="entry name" value="Acetate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004372">
        <property type="entry name" value="Ac/propionate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000890">
        <property type="entry name" value="Aliphatic_acid_kin_short-chain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023865">
        <property type="entry name" value="Aliphatic_acid_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00016">
        <property type="entry name" value="ackA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21060">
        <property type="entry name" value="ACETATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21060:SF15">
        <property type="entry name" value="ACETATE KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00871">
        <property type="entry name" value="Acetate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000722">
        <property type="entry name" value="Acetate_prop_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00471">
        <property type="entry name" value="ACETATEKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01075">
        <property type="entry name" value="ACETATE_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01076">
        <property type="entry name" value="ACETATE_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5 6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Proton donor/acceptor" evidence="5">
        <location>
            <position position="154"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="8"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="15"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="214"/>
            <end position="218"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="398"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="5">
        <location>
            <position position="186"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="5">
        <location>
            <position position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAF99181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="418" mass="45707" checksum="BFE49284AF86E8C1" modified="2016-09-07" version="1">MEIILSINAGSSSVKISVYKAEPSSSRPHQLAEATIEGLTAPPVKLKYSRGDETIKGNELQDIASQEDAFKYILTHLENDPGLPELSKTDDIHFTCHRVVHGGDYPATQIIDKETYHHIEELSDLAPLHNAPALSIVRAVSKMLPNAKNVAYFDSSFHATIPRHICTYPIDQKVAEKNKLRKYGFHGISYQFITDAVASHLKKDPKTLSIIALHLGSGASACCIKNGRSHDTSMGLTPLAGLPGATRSGSIDPSLIFHFTHSAGSLSHAAAGHMHITQAEEILNKKSGWKALTGTTDFGEISSSDEEMKTLAFDIFVDRITNYVAPYFAKLDGEVDALVFAGGIGERGSKLRKEVVRGVECLGFKLDAEKNEKPEDEVVVDISAADARFRTLICQTDEQLQMARGVLGDRQRLMQKKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BX09</accession>
    <name>A0A177BX09_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transcriptional activator HAP2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_1104971</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Heterotrimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the NFYA/HAP2 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441563">
        <property type="protein sequence ID" value="OAF99047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029413.1">
        <property type="nucleotide sequence ID" value="XM_018175076.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BX09"/>
    <dbReference type="STRING" id="1460663.A0A177BX09"/>
    <dbReference type="GeneID" id="28758562"/>
    <dbReference type="InParanoid" id="A0A177BX09"/>
    <dbReference type="OrthoDB" id="1097733at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001289">
        <property type="entry name" value="NFYA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12632">
        <property type="entry name" value="TRANSCRIPTION FACTOR NF-Y ALPHA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02045">
        <property type="entry name" value="CBFB_NFYA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00616">
        <property type="entry name" value="CCAATSUBUNTB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00521">
        <property type="entry name" value="CBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51152">
        <property type="entry name" value="NFYA_HAP2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 6" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="110"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="252"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="159"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="199"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="307"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="346"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAF99047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="361" mass="38742" checksum="9C380A73863D5876" modified="2016-09-07" version="1">MTDYAQYQQPHHGHAPTHMQNYPGAQNPGAPNPSITSPTQGQMHSYQQTSPILPSQGYPQPGAPNAQHQQMNYPQGYMPGMHQQYGMSPTQAAAMATAAAAGPAGYYDPNQMGQGQLAQDPRASPRMSGGQIKQDGRGPPRSPTAVSNAMGAGGIASQVPMNPGQQAIQRRMSTQIHSPAMQQPQPVMAHAAARPSVPPMAQQAPQQHQQSPELVAGAQAEEAPLYVNAKQFHRILKRRLARQKLEDALRLTSKGRKPYLHESRHNHAMRRPRGPGGRFLTAEEVAQMEANKGSGLEGEDGGDKENANSAIKSTASSANSGTKRKASSTNLKGATKKKANRRTSTSEEDEDEDEDDADDDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BXK1</accession>
    <name>A0A177BXK1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Sugar transporter STL1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CC84DRAFT_1131304</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441562">
        <property type="protein sequence ID" value="OAF99418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029784.1">
        <property type="nucleotide sequence ID" value="XM_018175893.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BXK1"/>
    <dbReference type="GeneID" id="28759379"/>
    <dbReference type="InParanoid" id="A0A177BXK1"/>
    <dbReference type="OrthoDB" id="2544694at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000090">
        <property type="entry name" value="MFS sugar transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF78">
        <property type="entry name" value="MONOSACCHARIDE TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G02110)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="16"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="70"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="100"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="124"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="160"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="198"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="304"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="330"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="357"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="399"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="434"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="463"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="22"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAF99418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="553" mass="61439" checksum="A7ACF7BF30DC7BD1" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BXZ6</accession>
    <name>A0A177BXZ6_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA ligase</fullName>
            <ecNumber evidence="7">6.5.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CC84DRAFT_1209907</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>ATP + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m = (deoxyribonucleotide)n+m + AMP + diphosphate.</text>
            <dbReference type="EC" id="6.5.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the ATP-dependent DNA ligase family.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.1" evidence="7"/>
    <dbReference type="EMBL" id="KV441561">
        <property type="protein sequence ID" value="OAF99571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029937.1">
        <property type="nucleotide sequence ID" value="XM_018182250.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BXZ6"/>
    <dbReference type="STRING" id="1460663.A0A177BXZ6"/>
    <dbReference type="GeneID" id="28765736"/>
    <dbReference type="InParanoid" id="A0A177BXZ6"/>
    <dbReference type="OrthoDB" id="206088at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003910">
        <property type="term" value="F:DNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006273">
        <property type="term" value="P:lagging strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07900">
        <property type="entry name" value="Adenylation_DNA_ligase_I_Euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07969">
        <property type="entry name" value="OBF_DNA_ligase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3260.10:FF:000004">
        <property type="entry name" value="DNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000062">
        <property type="entry name" value="DNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.30:FF:000018">
        <property type="entry name" value="DNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3260.10">
        <property type="entry name" value="DNA ligase, ATP-dependent, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.30">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050191">
        <property type="entry name" value="ATP-dep_DNA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000977">
        <property type="entry name" value="DNA_ligase_ATP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012309">
        <property type="entry name" value="DNA_ligase_ATP-dep_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012310">
        <property type="entry name" value="DNA_ligase_ATP-dep_cent"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016059">
        <property type="entry name" value="DNA_ligase_ATP-dep_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012308">
        <property type="entry name" value="DNA_ligase_ATP-dep_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036599">
        <property type="entry name" value="DNA_ligase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00574">
        <property type="entry name" value="dnl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45674">
        <property type="entry name" value="DNA LIGASE 1/3 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45674:SF9">
        <property type="entry name" value="DNA LIGASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04679">
        <property type="entry name" value="DNA_ligase_A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01068">
        <property type="entry name" value="DNA_ligase_A_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04675">
        <property type="entry name" value="DNA_ligase_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117018">
        <property type="entry name" value="ATP-dependent DNA ligase DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56091">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00697">
        <property type="entry name" value="DNA_LIGASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50160">
        <property type="entry name" value="DNA_LIGASE_A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="2 7 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-dependent DNA ligase family profile" evidence="10">
        <location>
            <begin position="554"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="645"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="28"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="48"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="75"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="645"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="660"/>
            <end position="670"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OAF99571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="892" mass="98739" checksum="EBBA4C3DFDA7EB00" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BYD4</accession>
    <name>A0A177BYD4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Six-hairpin glycosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1263846</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441560">
        <property type="protein sequence ID" value="OAG00146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030511.1">
        <property type="nucleotide sequence ID" value="XM_018185263.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BYD4"/>
    <dbReference type="STRING" id="1460663.A0A177BYD4"/>
    <dbReference type="GeneID" id="28768749"/>
    <dbReference type="InParanoid" id="A0A177BYD4"/>
    <dbReference type="OrthoDB" id="10036721at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.10:FF:000052">
        <property type="entry name" value="Alpha-L-rhamnosidase B, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.420.10">
        <property type="entry name" value="Maltose phosphorylase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035396">
        <property type="entry name" value="Bac_rhamnosid6H"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34987:SF5">
        <property type="entry name" value="ALPHA-RHAMNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34987">
        <property type="entry name" value="C, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G02880)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17389">
        <property type="entry name" value="Bac_rhamnosid6H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008057538" evidence="1">
        <location>
            <begin position="21"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-L-rhamnosidase six-hairpin glycosidase" evidence="2">
        <location>
            <begin position="248"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG00146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="680" mass="74354" checksum="5F948CF1B9B925D4" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BYX2</accession>
    <name>A0A177BYX2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ca/Cm-dependent protein kinase B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CC84DRAFT_374226</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV441561">
        <property type="protein sequence ID" value="OAF99626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029992.1">
        <property type="nucleotide sequence ID" value="XM_018185957.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BYX2"/>
    <dbReference type="STRING" id="1460663.A0A177BYX2"/>
    <dbReference type="GeneID" id="28769443"/>
    <dbReference type="InParanoid" id="A0A177BYX2"/>
    <dbReference type="OrthoDB" id="40902at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004683">
        <property type="term" value="F:calcium/calmodulin-dependent protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071277">
        <property type="term" value="P:cellular response to calcium ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106057">
        <property type="term" value="P:negative regulation of calcineurin-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010972">
        <property type="term" value="P:negative regulation of G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd05117">
        <property type="entry name" value="STKc_CAMK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000153">
        <property type="entry name" value="Calcium/calmodulin-dependent protein kinase type I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:002036">
        <property type="entry name" value="Gliding motility related CaM kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24347">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="1 3 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="25"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="336"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="364"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAF99626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="401" mass="44695" checksum="A250E3F7E4F86D01" modified="2016-09-07" version="1">MASNGGSGAHTPNAQAQAQVQPCRYKTGKTLGAGSYSVVKECVHIDTGRYYAAKVINKRLMAGREHMVRNEIAVLKRVSMGHRNILTLVDYFETMNNLYLVTDLALGGELFDRICRKGNYYESDAADLIRATLSAVAYLHDHGIVHRDLKPENLLFRTPEDNADLLIADFGLSRIMDEEQFHVLTTTCGTPGYMAPEIFRKTGHGKPVDIWAIGVITYFLLCGYTPFDRDSNLEEMQAILVADYSFTPLEYWRGVSLKAREFIRRCLTVDPAARMTAHEALSHPWIADLGDISAEGEEDLLPTVKKNFNARRTLHAAIDTIRAINQLRAGGAAGMMDGARSGEPRRGAPPLNVPQPVADEDPMDIDKIDSRGNGHGQTDEMIREQERRIHETQQGLWAGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BZR3</accession>
    <name>A0A177BZR3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_268068</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441558">
        <property type="protein sequence ID" value="OAG00863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031228.1">
        <property type="nucleotide sequence ID" value="XM_018185672.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BZR3"/>
    <dbReference type="GeneID" id="28769158"/>
    <dbReference type="InParanoid" id="A0A177BZR3"/>
    <dbReference type="OrthoDB" id="2328572at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045122">
        <property type="term" value="P:aflatoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013700">
        <property type="entry name" value="AflR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050675">
        <property type="entry name" value="OAF3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31069:SF31">
        <property type="entry name" value="MONODICTYPHENONE CLUSTER TRANSCRIPTION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31069">
        <property type="entry name" value="OLEATE-ACTIVATED TRANSCRIPTION FACTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08493">
        <property type="entry name" value="AflR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00755">
        <property type="entry name" value="AFLATOXINBRP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="49"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="80"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="13"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="29"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="82"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="132"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAG00863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="473" mass="52538" checksum="7D4F64827296BE46" modified="2016-09-07" version="1">MNTMEFKQQTPEWQPPLTPSQPIPPTSTPRPATTTPKSASDRRPKLRASCDACAASKVKCSKEHPICARCRANGSQCIYGVSRKHGKPGRTRKRNPDGTPFIKASKQRPSPDGSEFSKFRVRPEPIISSREATPSSNWSPTPSWPATPEFEFEMTPEPFYLEPSPDFNNYMGDMSAYMPLQPEFESFQPIQSELTFIDPFARKQSVRLDLPDIQAIRDFVTVDTVNTVNPMEVPFPGSMPVDNGFLPPSNTVSPHSPKSTPSYSQNPLRFSISMPTQHCCYTLAYQTLESLRIINPQNSTNVELKSLDSVLSITKEAVANVLQLLNCPCSSDPHLAMLYSSITSKILTWYQIAAGVQPTVPSTPPSLSAASSPSSSVFSSPLSTPSSENTTFNIAVQPITIGLFEFDEDMQQTLRRQVVLRELRKCGTLVEALANWGSPQKTTQAEYLYDVLGAWLKTELYKTLREVEGEQML</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BZS5</accession>
    <name>A0A177BZS5_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CC84DRAFT_1102849</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441560">
        <property type="protein sequence ID" value="OAG00092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030457.1">
        <property type="nucleotide sequence ID" value="XM_018174984.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BZS5"/>
    <dbReference type="STRING" id="1460663.A0A177BZS5"/>
    <dbReference type="GeneID" id="28758470"/>
    <dbReference type="InParanoid" id="A0A177BZS5"/>
    <dbReference type="OrthoDB" id="444631at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF18">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="92"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="170"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="203"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="238"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="20"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="297"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="297"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="314"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAG00092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="329" mass="37077" checksum="5EE2FE2FF1F266F9" modified="2016-09-07" version="1">MAQTTAWSLTVIALLTTLGRFAIHWHRRQRIAWDDFFNGLAMAFLLAFTGTYQVYGPTDYTKQLYAMGLIKEDEVVHSDEKRNAKYNAANALLFWCVVYAAKASFLALYWHIFAFSTKFRIAWAVTTAYIPTSFAITFMWSFFLCGNPKYFPDIQPQCHDNAPAMVVPMLSAWCALDLIGDLLLVVLPLAMLRPLLMRTAQKLELAIIFLLVAVNMVLTILRTVYSIDVDLARFPDQNVLWCFLQASGAVIVCALPCYRGILTRKKPDSLSSDGLNTSESEFADIWQRYLISIGEHKEGSRTEREKDLEAGVTKGSSGTQTHISEIARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BZY2</accession>
    <name>A0A177BZY2_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GH16 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1102666</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441560">
        <property type="protein sequence ID" value="OAG00118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030483.1">
        <property type="nucleotide sequence ID" value="XM_018174975.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BZY2"/>
    <dbReference type="STRING" id="1460663.A0A177BZY2"/>
    <dbReference type="GeneID" id="28758461"/>
    <dbReference type="InParanoid" id="A0A177BZY2"/>
    <dbReference type="OrthoDB" id="192832at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF24">
        <property type="entry name" value="GLYCOSIDASE C21B10.07-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26113">
        <property type="entry name" value="GH16_XgeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG00118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="285" mass="31490" checksum="CC8BB8114440C0F7" modified="2016-09-07" version="1">MFGHKKEPDTSFTQGFAQYVSSDEATAMGLASIVDNKAHIGVDTNNTYDLGSTGRKSVRLQSYGTFDQGLLVADLAHVPVAGCGQWPAFWVYRGEQAEGYSEIDILENVDKSTANTHSFYTSEECSVNFDVGNPLKTDNCHYNPQGEGLQGCSFGAEEGTFNQAFNEQYQVIALQVETDTMRIWHFRKDEIPADLNAGTPDPSTWKTPTVALSPKSCDFQKAFSQFKIIINITFCGSWAGGADSWNEQCAAETGTDCNSWVANNPDDFKDTFFEFNSVKLYQRTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C074</accession>
    <name>A0A177C074_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Lysophospholipase</fullName>
            <ecNumber evidence="6">3.1.1.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CC84DRAFT_1128366</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 1-acyl-sn-glycero-3-phosphocholine + H2O = sn-glycerol 3-phosphocholine + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15177"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16870"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:58168"/>
            <dbReference type="EC" id="3.1.1.5"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the lysophospholipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.5" evidence="6"/>
    <dbReference type="EMBL" id="KV441558">
        <property type="protein sequence ID" value="OAG01043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031408.1">
        <property type="nucleotide sequence ID" value="XM_018175797.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C074"/>
    <dbReference type="STRING" id="1460663.A0A177C074"/>
    <dbReference type="GeneID" id="28759283"/>
    <dbReference type="InParanoid" id="A0A177C074"/>
    <dbReference type="OrthoDB" id="6121437at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004622">
        <property type="term" value="F:phosphatidylcholine lysophospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004623">
        <property type="term" value="F:phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046475">
        <property type="term" value="P:glycerophospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00147">
        <property type="entry name" value="cPLA2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002642">
        <property type="entry name" value="LysoPLipase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10728">
        <property type="entry name" value="CYTOSOLIC PHOSPHOLIPASE A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10728:SF40">
        <property type="entry name" value="PATATIN FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01735">
        <property type="entry name" value="PLA2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00022">
        <property type="entry name" value="PLAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51210">
        <property type="entry name" value="PLA2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5 6" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="4 5 6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PLA2c" evidence="8">
        <location>
            <begin position="201"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="82"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="623"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="777"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="85"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="117"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="637"/>
            <end position="675"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAG01043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="819" mass="91697" checksum="623EF5FD25AAC671" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C0N8</accession>
    <name>A0A177C0N8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Short-chain dehydrogenase/reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1168338</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441558">
        <property type="protein sequence ID" value="OAG01203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031568.1">
        <property type="nucleotide sequence ID" value="XM_018179372.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C0N8"/>
    <dbReference type="FunCoup" id="A0A177C0N8">
        <property type="interactions" value="241"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177C0N8"/>
    <dbReference type="GeneID" id="28762858"/>
    <dbReference type="InParanoid" id="A0A177C0N8"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157:SF31">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG01203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="317" mass="33498" checksum="B1D5D9ED374AB74E" modified="2016-09-07" version="1">MVSFDPAKDIPSLSGKVILVTGGNIGLGKQCILEYARHNPSRIYLAARSPSKAQAAIDEVKQQLGTSNSTPISILELDLSSLSSVKLAAAKLLGQESRLDILMLNAGIMAAAPGLTKDGYEMQFGVNYLGHALLFKLLLPLLEKTSNLPGADVRAIMVTSVGHQLAPKEGIPFDQLQTDCENLGAFERYGASKLAQILWARHAATLYPNITFAAAHPGLVGGTGLGSSATGTSAFANMLMALSPLAATSLEKGARNQLWTSVGKDVKSGEWYAPETCIGVMQVGVGSQSGASALAKDNSLAERLWKWTETNLHSYSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C1P6</accession>
    <name>A0A177C1P6_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">LCCL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_1190646</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441559">
        <property type="protein sequence ID" value="OAG00647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031012.1">
        <property type="nucleotide sequence ID" value="XM_018181127.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C1P6"/>
    <dbReference type="FunCoup" id="A0A177C1P6">
        <property type="interactions" value="4"/>
    </dbReference>
    <dbReference type="GeneID" id="28764613"/>
    <dbReference type="InParanoid" id="A0A177C1P6"/>
    <dbReference type="OrthoDB" id="441660at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.20">
        <property type="entry name" value="LCCL-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051957">
        <property type="entry name" value="CRISP-LCCL_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004043">
        <property type="entry name" value="LCCL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036609">
        <property type="entry name" value="LCCL_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31331:SF1">
        <property type="entry name" value="CYSTEINE RICH SECRETORY PROTEIN LCCL DOMAIN CONTAINING 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31331">
        <property type="entry name" value="LCCL DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G08630)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03815">
        <property type="entry name" value="LCCL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00603">
        <property type="entry name" value="LCCL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69848">
        <property type="entry name" value="LCCL domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50820">
        <property type="entry name" value="LCCL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="268"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="313"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="354"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="388"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="421"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="domain" description="LCCL" evidence="3">
        <location>
            <begin position="182"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAG00647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="603" mass="66327" checksum="83EDE74E4D9123CA" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C266</accession>
    <name>A0A177C266_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CC84DRAFT_1168361</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441558">
        <property type="protein sequence ID" value="OAG01251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031616.1">
        <property type="nucleotide sequence ID" value="XM_018179378.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C266"/>
    <dbReference type="STRING" id="1460663.A0A177C266"/>
    <dbReference type="GeneID" id="28762864"/>
    <dbReference type="InParanoid" id="A0A177C266"/>
    <dbReference type="OrthoDB" id="295274at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14687">
        <property type="entry name" value="bZIP_ATF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051027">
        <property type="entry name" value="bZIP_transcription_factors"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19304">
        <property type="entry name" value="CYCLIC-AMP RESPONSE ELEMENT BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07716">
        <property type="entry name" value="bZIP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="6">
        <location>
            <begin position="198"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="135"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="271"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="142"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="155"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="202"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="287"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAG01251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="301" mass="32703" checksum="0700D97E77DC3911" modified="2016-09-07" version="1">MISTCSGSNTWTQHALRMRTPDDAGLAFSNIAPPPDQFLFVSDLGQHDEKPTIPSALALTLSGESQPQDFSSGASSDRPFAAAALYPLQTSFAAANANAMHMGDALHGSCMSPPQTRFNSDAGGCGSYDSTNNFSADDHAYSATSTTPTQWSYAMDREPPTSKRRPESVHGQMDSAPARRRRSSDKAEPGSARAVYLEKNRHAASKCRTKQKRQQEDLVETARDAERKNKVLKSEVELLKSDLRGLMELVGQHHECPDGRLRTYLQLEADRLSQRGNRSTVGELRSPKSSVSGDSSSPGNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C2Z5</accession>
    <name>A0A177C2Z5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Thioredoxin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CC84DRAFT_1198734</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441557">
        <property type="protein sequence ID" value="OAG01541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031906.1">
        <property type="nucleotide sequence ID" value="XM_018181587.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C2Z5"/>
    <dbReference type="FunCoup" id="A0A177C2Z5">
        <property type="interactions" value="93"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177C2Z5"/>
    <dbReference type="GeneID" id="28765073"/>
    <dbReference type="InParanoid" id="A0A177C2Z5"/>
    <dbReference type="OrthoDB" id="72053at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd02961">
        <property type="entry name" value="PDI_a_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052250">
        <property type="entry name" value="PDI_TMX3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46426">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE TMX3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46426:SF1">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE TMX3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00421">
        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008057719" evidence="7">
        <location>
            <begin position="20"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="656"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="8">
        <location>
            <begin position="45"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="8">
        <location>
            <begin position="234"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="181"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="215"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="233"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAG01541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="700" mass="79195" checksum="0F30731CD22E7996" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C3H7</accession>
    <name>A0A177C3H7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CoA-transferase family III</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1168347</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CoA-transferase III family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441558">
        <property type="protein sequence ID" value="OAG01220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031585.1">
        <property type="nucleotide sequence ID" value="XM_018179374.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C3H7"/>
    <dbReference type="STRING" id="1460663.A0A177C3H7"/>
    <dbReference type="GeneID" id="28762860"/>
    <dbReference type="InParanoid" id="A0A177C3H7"/>
    <dbReference type="OrthoDB" id="2308815at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10540">
        <property type="entry name" value="Crotonobetainyl-coa:carnitine coa-transferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052985">
        <property type="entry name" value="CoA-trans_III_biosynth/detox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003673">
        <property type="entry name" value="CoA-Trfase_fam_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023606">
        <property type="entry name" value="CoA-Trfase_III_dom_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48229">
        <property type="entry name" value="CAIB/BAIF FAMILY ENZYME (AFU_ORTHOLOGUE AFUA_1G05360)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48229:SF2">
        <property type="entry name" value="CAIB_BAIF FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02515">
        <property type="entry name" value="CoA_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89796">
        <property type="entry name" value="CoA-transferase family III (CaiB/BaiF)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG01220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="583" mass="65165" checksum="F019B415AA26FDBE" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C4E5</accession>
    <name>A0A177C4E5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1208830</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441557">
        <property type="protein sequence ID" value="OAG01759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032124.1">
        <property type="nucleotide sequence ID" value="XM_018182187.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C4E5"/>
    <dbReference type="GeneID" id="28765673"/>
    <dbReference type="InParanoid" id="A0A177C4E5"/>
    <dbReference type="OrthoDB" id="3785858at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG01759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="204" mass="23006" checksum="A4D86F37D8B2188D" modified="2016-09-07" version="1">MAGSNFNTIYNAPEFTHEHQRAYEKMFYGMNSEFANIQDGYLDKDYDRPVVFGNGNNEQLAFAPQGNFEERDLNYKAVDAYARATRKSWGRRFTQPLLSFPSRVASIAIPAASYLGSVAGKPTQIKPVLGKRRRCVCGDCDDCTTGKERWVPLGPVGQPANNVTNPNIHDYVRPPRKLRFGGWFQGKEDNSWTVDPRTGHRIPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C4J7</accession>
    <name>A0A177C4J7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1229137</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441557">
        <property type="protein sequence ID" value="OAG01809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032174.1">
        <property type="nucleotide sequence ID" value="XM_018183654.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C4J7"/>
    <dbReference type="GeneID" id="28767140"/>
    <dbReference type="InParanoid" id="A0A177C4J7"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="11"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG01809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="163" mass="17795" checksum="3C04DD6A0525394B" modified="2016-09-07" version="1">MPFCLLCSTGGRTTTSQTTEKTRQAYSGTRYDCSPSSRRHATDNPSLRFAQRTKARPISPTSLRTRASPPFVPRYSPILTPKPRSSVAHWRSAPSLNSTFTLAGSHTRLRTPTAPSNNSGSFHMRRPWPIITASHPSAPSALGPSTRVFSSAAKAVEGERQSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C4L3</accession>
    <name>A0A177C4L3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_897956</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG02573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032938.1">
        <property type="nucleotide sequence ID" value="XM_018187834.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C4L3"/>
    <dbReference type="GeneID" id="28771320"/>
    <dbReference type="InParanoid" id="A0A177C4L3"/>
    <dbReference type="OrthoDB" id="3795696at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG02573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="114" mass="12793" checksum="840577DDAB20794A" modified="2016-09-07" version="1">MAPATQAPVKRATYDGSRPRFQTLDAWLTVYGNAEYAIYKRDAAPNALSYEEWSQSEHVLGPFLWYTTLDVWEEDSSSDEESDAEAPAFTARAPPKEQPKKLVIKNGQSKRGPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C4T9</accession>
    <name>A0A177C4T9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1221280</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441557">
        <property type="protein sequence ID" value="OAG01808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032173.1">
        <property type="nucleotide sequence ID" value="XM_018183253.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C4T9"/>
    <dbReference type="GeneID" id="28766739"/>
    <dbReference type="InParanoid" id="A0A177C4T9"/>
    <dbReference type="OrthoDB" id="4323739at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.20.10">
        <property type="entry name" value="Crystallins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011024">
        <property type="entry name" value="G_crystallin-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49695">
        <property type="entry name" value="gamma-Crystallin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG01808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="69" mass="7595" checksum="9D5C9372C684986D" modified="2016-09-07" version="1">MIDFTTDRLGGTEWNDVISSVKVPDGHRCRLWSSNNCNGDSSPDIYAPGAKQLPGGMNNRATSFKCYQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C541</accession>
    <name>A0A177C541_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">M6 metalloprotease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1166395</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG02556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032921.1">
        <property type="nucleotide sequence ID" value="XM_018178954.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C541"/>
    <dbReference type="GeneID" id="28762440"/>
    <dbReference type="InParanoid" id="A0A177C541"/>
    <dbReference type="OrthoDB" id="3941110at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008757">
        <property type="entry name" value="Peptidase_M6-like_domain"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03296">
        <property type="entry name" value="M6dom_TIGR03296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41775:SF1">
        <property type="entry name" value="PEPTIDASE M6-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41775">
        <property type="entry name" value="SECRETED PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG02556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="417" mass="44005" checksum="D2359A212A69344B" modified="2016-09-07" version="1">MRSLSYSSVMGCAMLHGAFTYAATPDTSSSCEAVTVTETVTATGDPVPTTSPPTPSPAPCRPSWDSTAKAPSTGRLRAGLIFVDFSDTPASASGQTPSELFEPLREQPADLYRDMSFGNLEFEIVPLLDTFYRMPNISAAYGFADDEGLTAEEHGRYIADALAIVGDAFDFASVDVLFIAPPKDTDEINRSAQYNSPVTAPGGREFAAGTVITFGTDLYPEGAWKTINHETGHAMGLPDLYPYGAGGNGLWVGGFDMMGIVWGQSPDLFAWHKWHLNWIEESQVDCVTEAGTSIHQLAPIEVEGGVKAVAIPVNATGYVMAEVRSTQGIDHAACEAATGVLLYTADAAVGSGDGPVRVIDANPGSEGCDSEANGAVLNDAPLRGVGATFDTEMGVKVTILSQSGDDYIIQVEREVLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C6Y3</accession>
    <name>A0A177C6Y3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1178174</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG02538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032903.1">
        <property type="nucleotide sequence ID" value="XM_018180324.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C6Y3"/>
    <dbReference type="STRING" id="1460663.A0A177C6Y3"/>
    <dbReference type="GeneID" id="28763810"/>
    <dbReference type="InParanoid" id="A0A177C6Y3"/>
    <dbReference type="OrthoDB" id="2115692at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052523">
        <property type="entry name" value="Trichothecene_AcTrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791">
        <property type="entry name" value="GNAT FAMILY ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791:SF2">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="63"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG02538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="222" mass="25086" checksum="A55121EF350ECFA9" modified="2016-09-07" version="1">MSITIVLATPTNLSTLATINLAAYSYSLAFHFAHKNWRDTTALLLFFSARLAIRFDSSTSQGLKAVDAISQDVLSFICWTRESGEGEKVVPTRQMLERMPDTMNKEFVEESGKVMEEMMVHLRGEEHYYLSSFAVAPAHQGEGIGSQLLQHGVQMADEARLASWLMVLPGSHELYKRYGHEDVDHRDVDLDKWDAGKKRGCGIYQNRAMKRACRPIEQSNDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C770</accession>
    <name>A0A177C770_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transmembrane 9 superfamily member</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_1122967</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG03594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033959.1">
        <property type="nucleotide sequence ID" value="XM_018175644.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C770"/>
    <dbReference type="FunCoup" id="A0A177C770">
        <property type="interactions" value="951"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177C770"/>
    <dbReference type="GeneID" id="28759130"/>
    <dbReference type="InParanoid" id="A0A177C770"/>
    <dbReference type="OrthoDB" id="1666796at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072657">
        <property type="term" value="P:protein localization to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004240">
        <property type="entry name" value="EMP70"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10766:SF111">
        <property type="entry name" value="TRANSMEMBRANE 9 SUPERFAMILY MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10766">
        <property type="entry name" value="TRANSMEMBRANE 9 SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02990">
        <property type="entry name" value="EMP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007948932" description="Transmembrane 9 superfamily member" evidence="7">
        <location>
            <begin position="27"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="284"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="358"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="392"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="429"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="464"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="520"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="548"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="588"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="627"/>
            <end position="649"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAG03594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="658" mass="73297" checksum="DD28C43D172E6D5E" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C7P2</accession>
    <name>A0A177C7P2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1261427</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG02720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033085.1">
        <property type="nucleotide sequence ID" value="XM_018185063.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C7P2"/>
    <dbReference type="STRING" id="1460663.A0A177C7P2"/>
    <dbReference type="GeneID" id="28768549"/>
    <dbReference type="InParanoid" id="A0A177C7P2"/>
    <dbReference type="OrthoDB" id="4764735at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG02720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="199" mass="21835" checksum="0993758E5EFA2002" modified="2016-09-07" version="1">MLTPTHVALGLHGSWIVLWFDGNLSYNLRSSYPGIGENIALTGGVGQVLFVALNPYEEDGYFVAEKDGCSFSTNLSSKTDGREVQKMMEDYMQMKAKRDNATFNDSFMMNEVKQMLYITTTSYERRRANSLFETWKQRRNLLLQREIISLIGSGSTAMYVSSSYAEASSVRAAGAAAATGVGLAAIMLSGIGDGFRTSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C896</accession>
    <name>A0A177C896_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1261586</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG02920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033285.1">
        <property type="nucleotide sequence ID" value="XM_018185078.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C896"/>
    <dbReference type="GeneID" id="28768564"/>
    <dbReference type="InParanoid" id="A0A177C896"/>
    <dbReference type="OrthoDB" id="5169850at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG02920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="287" mass="32601" checksum="2749E5BE557030B7" modified="2016-09-07" version="1">MTQNNNTKTPNPSNPSSLKPRYEIRQLEPKHSEWACAIVIHSNLFHSPVWPVLYPEGLNARTFEGLDNASYLVNHQIDSGHSFGVFDTEYQFKREESKATGGKLYWDRNEKSVQEENGMEAEGQRLLEQMDFPLVSVALSYDGADPLDLEKLGPLLAVLPHFGPLYHVLEVLDPREKESWAPKAHKEVLMRNATATRHDYEGEKIMAGMARWLMREADARGFRAIQIECVHDAVTHVWSDPPAPYKGGIVSEFHTGTFKDEEGQLLFAPAQQRITKCYVELKPKAQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C8J4</accession>
    <name>A0A177C8J4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Subtilisin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CC84DRAFT_1166854</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 9 10">Belongs to the peptidase S8 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG03098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033463.1">
        <property type="nucleotide sequence ID" value="XM_018179065.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C8J4"/>
    <dbReference type="STRING" id="1460663.A0A177C8J4"/>
    <dbReference type="GeneID" id="28762551"/>
    <dbReference type="InParanoid" id="A0A177C8J4"/>
    <dbReference type="OrthoDB" id="10256524at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02124">
        <property type="entry name" value="PA_PoS1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07489">
        <property type="entry name" value="Peptidases_S8_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1710">
        <property type="entry name" value="Subtilisin-like superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010435">
        <property type="entry name" value="C5a/SBT2-like_Fn3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046450">
        <property type="entry name" value="PA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003137">
        <property type="entry name" value="PA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050131">
        <property type="entry name" value="Peptidase_S8_subtilisin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034187">
        <property type="entry name" value="Peptidases_S8_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806">
        <property type="entry name" value="PEPTIDASE S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806:SF66">
        <property type="entry name" value="SERIN ENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06280">
        <property type="entry name" value="fn3_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02225">
        <property type="entry name" value="PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52025">
        <property type="entry name" value="PA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0134">Cell wall</keyword>
    <keyword evidence="6 9 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 9 10" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="7 9 10" id="KW-0720">Serine protease</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Peptidase S8/S53" evidence="12">
        <location>
            <begin position="97"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="domain" description="PA" evidence="13">
        <location>
            <begin position="324"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="C5a peptidase/Subtilisin-like protease SBT2-like Fn3-like" evidence="14">
        <location>
            <begin position="555"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="687"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="699"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8 9">
        <location>
            <position position="106"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8 9">
        <location>
            <position position="156"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8 9">
        <location>
            <position position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR615500-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF06280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OAG03098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="816" mass="85029" checksum="2467CBE6CF69A040" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C950</accession>
    <name>A0A177C950_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_835234</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG03382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033747.1">
        <property type="nucleotide sequence ID" value="XM_018187597.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C950"/>
    <dbReference type="GeneID" id="28771083"/>
    <dbReference type="InParanoid" id="A0A177C950"/>
    <dbReference type="OrthoDB" id="20105at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG03382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="176" mass="19495" checksum="6480274FA0C9C79B" modified="2016-09-07" version="1">MSGQIPRNTSQPPQYGSDNQNPYSNPWGSESQAQNTAQSHGQPTQAQDHNPFHTQDQPQSYDSFVQEQSYNPPSQPPLGQHNEQYTPPPGLPPRRIGTTSEQALPQGQDRSHQVEVMQSYEMSRPQTEDEQNQAILEREFPKIDGSLIAAIYGDSGSLSATREMLQELSSTEGQGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C9K5</accession>
    <name>A0A177C9K5_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">glucan endo-1,3-beta-D-glucosidase</fullName>
            <ecNumber evidence="3">3.2.1.39</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CC84DRAFT_1188202</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of (1-&gt;3)-beta-D-glucosidic linkages in (1-&gt;3)-beta-D-glucans.</text>
            <dbReference type="EC" id="3.2.1.39"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 81 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.39" evidence="3"/>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG03519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033884.1">
        <property type="nucleotide sequence ID" value="XM_018180977.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C9K5"/>
    <dbReference type="FunCoup" id="A0A177C9K5">
        <property type="interactions" value="210"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177C9K5"/>
    <dbReference type="GeneID" id="28764463"/>
    <dbReference type="InParanoid" id="A0A177C9K5"/>
    <dbReference type="OrthoDB" id="4473401at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052861">
        <property type="term" value="F:endo-1,3(4)-beta-glucanase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042973">
        <property type="term" value="F:glucan endo-1,3-beta-D-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.98.30:FF:000006">
        <property type="entry name" value="Endo-1,3-beta-glucanase Engl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1170">
        <property type="entry name" value="glycoside hydrolase family 81 endo-[beta] glucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.30">
        <property type="entry name" value="Golgi alpha-mannosidase II, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005200">
        <property type="entry name" value="Endo-beta-glucanase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040720">
        <property type="entry name" value="GH81_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040451">
        <property type="entry name" value="GH81_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31983">
        <property type="entry name" value="ENDO-1,3(4)-BETA-GLUCANASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31983:SF0">
        <property type="entry name" value="GLUCAN ENDO-1,3-BETA-D-GLUCOSIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17652">
        <property type="entry name" value="Glyco_hydro81C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03639">
        <property type="entry name" value="Glyco_hydro_81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52008">
        <property type="entry name" value="GH81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008057983" description="glucan endo-1,3-beta-D-glucosidase" evidence="10">
        <location>
            <begin position="19"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 81 N-terminal" evidence="11">
        <location>
            <begin position="136"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 81 C-terminal" evidence="12">
        <location>
            <begin position="469"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="850"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="852"/>
            <end position="915"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF17652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OAG03519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="922" mass="101200" checksum="6BDD1EB547DF2585" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C9P4</accession>
    <name>A0A177C9P4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RmlC-like cupin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_1206848</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the germin family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG03477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033842.1">
        <property type="nucleotide sequence ID" value="XM_018182061.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C9P4"/>
    <dbReference type="STRING" id="1460663.A0A177C9P4"/>
    <dbReference type="GeneID" id="28765547"/>
    <dbReference type="InParanoid" id="A0A177C9P4"/>
    <dbReference type="OrthoDB" id="1921208at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02241">
        <property type="entry name" value="cupin_OxOx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006045">
        <property type="entry name" value="Cupin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001929">
        <property type="entry name" value="Germin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31238">
        <property type="entry name" value="GERMIN-LIKE PROTEIN SUBFAMILY 3 MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00190">
        <property type="entry name" value="Cupin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00325">
        <property type="entry name" value="GERMIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00835">
        <property type="entry name" value="Cupin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008057987" evidence="6">
        <location>
            <begin position="19"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="Cupin type-1" evidence="7">
        <location>
            <begin position="55"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAG03477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="231" mass="25000" checksum="5D1456558D9ACB37" modified="2016-09-07" version="1">MVGHLFATILIFLPLVYATEKLDKTVNQDLVSRLKLAATVYDRHQILAKDEDWIYDFNSAQPTDSYKPGSVKNANAATFPAMVGHGMTVAQLNLGPCAMLPVHYHPRATNMVIAITGNTTTWMVNENGVRTVSTTLTPGKMTIFPLGSIHCMQNNGCDDAYLISALNSEDTGTMNIAGGLWSIRDDMIRAAFGNPAMDVQTTGKNIPEVGTGSTYGSDECMKRCGMSKGKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CAF0</accession>
    <name>A0A177CAF0_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glycogen [starch] synthase</fullName>
            <ecNumber evidence="8">2.4.1.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CC84DRAFT_1147373</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Glycogen synthase participates in the glycogen biosynthetic process along with glycogenin and glycogen branching enzyme. Extends the primer composed of a few glucose units formed by glycogenin by adding new glucose units to it. In this context, glycogen synthase transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan.</text>
    </comment>
    <comment type="function">
        <text evidence="8">Transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>[(1-&gt;4)-alpha-D-glucosyl](n) + UDP-alpha-D-glucose = [(1-&gt;4)-alpha-D-glucosyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18549"/>
            <dbReference type="Rhea" id="RHEA-COMP:9584"/>
            <dbReference type="Rhea" id="RHEA-COMP:9587"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15444"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.4.1.11"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:18550"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Glycan biosynthesis; glycogen biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the glycosyltransferase 3 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.11" evidence="8"/>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG04633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034998.1">
        <property type="nucleotide sequence ID" value="XM_018176589.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CAF0"/>
    <dbReference type="FunCoup" id="A0A177CAF0">
        <property type="interactions" value="426"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CAF0"/>
    <dbReference type="GeneID" id="28760075"/>
    <dbReference type="InParanoid" id="A0A177CAF0"/>
    <dbReference type="OrthoDB" id="6335297at2759"/>
    <dbReference type="UniPathway" id="UPA00164"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004373">
        <property type="term" value="F:alpha-1,4-glucan glucosyltransferase (UDP-glucose donor) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03793">
        <property type="entry name" value="GT3_GSY2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000014">
        <property type="entry name" value="Glycogen [starch] synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000045">
        <property type="entry name" value="Glycogen [starch] synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008631">
        <property type="entry name" value="Glycogen_synth"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10176:SF3">
        <property type="entry name" value="GLYCOGEN [STARCH] SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10176">
        <property type="entry name" value="GLYCOGEN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05693">
        <property type="entry name" value="Glycogen_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0320">Glycogen biosynthesis</keyword>
    <keyword evidence="3 8" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="623"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="667"/>
            <end position="724"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00043883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAG04633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="724" mass="81541" checksum="80BAE75147D89F29" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CAW2</accession>
    <name>A0A177CAW2_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">alpha-1,2-Mannosidase</fullName>
            <ecNumber evidence="9">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CC84DRAFT_1120935</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the glycosyl hydrolase 47 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="9"/>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG04486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034851.1">
        <property type="nucleotide sequence ID" value="XM_018175596.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CAW2"/>
    <dbReference type="FunCoup" id="A0A177CAW2">
        <property type="interactions" value="89"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CAW2"/>
    <dbReference type="GeneID" id="28759082"/>
    <dbReference type="InParanoid" id="A0A177CAW2"/>
    <dbReference type="OrthoDB" id="8118055at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004571">
        <property type="term" value="F:mannosyl-oligosaccharide 1,2-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.10:FF:000037">
        <property type="entry name" value="alpha-1,2-Mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001382">
        <property type="entry name" value="Glyco_hydro_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050749">
        <property type="entry name" value="Glycosyl_Hydrolase_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036026">
        <property type="entry name" value="Seven-hairpin_glycosidases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742:SF49">
        <property type="entry name" value="ALPHA-1,2-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE ALPHA-1,2-MANNOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01532">
        <property type="entry name" value="Glyco_hydro_47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00747">
        <property type="entry name" value="GLYHDRLASE47"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48225">
        <property type="entry name" value="Seven-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="5 8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="175"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="313"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="428"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="490"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="579"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="385"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAG04486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="590" mass="66506" checksum="B3A7709FF4204E81" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CB26</accession>
    <name>A0A177CB26_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Meiotically up-regulated gene 64 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1249637</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG04062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034427.1">
        <property type="nucleotide sequence ID" value="XM_018184291.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CB26"/>
    <dbReference type="FunCoup" id="A0A177CB26">
        <property type="interactions" value="57"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CB26"/>
    <dbReference type="GeneID" id="28767777"/>
    <dbReference type="InParanoid" id="A0A177CB26"/>
    <dbReference type="OrthoDB" id="5549748at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07600">
        <property type="entry name" value="BAR_Gvp36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018859">
        <property type="entry name" value="BAR_dom-cont"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10455">
        <property type="entry name" value="BAR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG04062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="320" mass="35034" checksum="0FA1B6298C5E6B6F" modified="2016-09-07" version="1">MENFQKLGAFGKNISASFTPFAARTQQLVKETLGQDVDKTQLPPDYIELEKRVDALKKVHNTMLQVTSQYSNEAYDYPTNIRESFNDLGRTVGEKVQLLSAATSPAEAQAALTAPPSAKPQPKTFSHAVARAAINSSHTLQGEHSGAGEDPLATALEKFAIASEKVGEARLAQDAQIQSKFLAGWSTTLNTNIMFATRARKAVENSRLSLDATKANVKGGAFSLPGQKAQQHTLNDEDLTEEQRAKIEQAEDEFVGQTEEAVGVMKNVLDTPEPLRNLADLIAAQLEYHKRAYEILSELAPVVDQLQVEQEVRRHDSSGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CBG2</accession>
    <name>A0A177CBG2_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF8004 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_894284</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG04202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034567.1">
        <property type="nucleotide sequence ID" value="XM_018187811.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CBG2"/>
    <dbReference type="STRING" id="1460663.A0A177CBG2"/>
    <dbReference type="GeneID" id="28771297"/>
    <dbReference type="InParanoid" id="A0A177CBG2"/>
    <dbReference type="OrthoDB" id="5300331at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058317">
        <property type="entry name" value="DUF8004"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39601">
        <property type="entry name" value="CHORIOGENIN HMINOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39601:SF2">
        <property type="entry name" value="CHORIOGENIN HMINOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26013">
        <property type="entry name" value="DUF8004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF8004" evidence="2">
        <location>
            <begin position="379"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="249"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="795"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="33"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="99"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="250"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="809"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="838"/>
            <end position="851"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG04202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="884" mass="97859" checksum="57BFF1C1DAED2E9A" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CBJ4</accession>
    <name>A0A177CBJ4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Snare protein-like protein Snc2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CC84DRAFT_1218450</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the synaptobrevin family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG05063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035428.1">
        <property type="nucleotide sequence ID" value="XM_018182998.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CBJ4"/>
    <dbReference type="FunCoup" id="A0A177CBJ4">
        <property type="interactions" value="318"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CBJ4"/>
    <dbReference type="GeneID" id="28766484"/>
    <dbReference type="InParanoid" id="A0A177CBJ4"/>
    <dbReference type="OrthoDB" id="190375at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051285">
        <property type="term" value="C:cell cortex of cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031097">
        <property type="term" value="C:medial cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090619">
        <property type="term" value="C:meiotic spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032120">
        <property type="term" value="P:ascospore-type prospore membrane formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15874">
        <property type="entry name" value="R-SNARE_Snc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000063">
        <property type="entry name" value="Synaptobrevin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001388">
        <property type="entry name" value="Synaptobrevin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016444">
        <property type="entry name" value="Synaptobrevin/VAMP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042855">
        <property type="entry name" value="V_SNARE_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45701">
        <property type="entry name" value="SYNAPTOBREVIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00957">
        <property type="entry name" value="Synaptobrevin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005409">
        <property type="entry name" value="Synaptobrevin_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00219">
        <property type="entry name" value="SYNAPTOBREVN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00417">
        <property type="entry name" value="SYNAPTOBREVIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50892">
        <property type="entry name" value="V_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="V-SNARE coiled-coil homology" evidence="10">
        <location>
            <begin position="31"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OAG05063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="120" mass="13215" checksum="D6ABB502BD8EE7D2" modified="2016-09-07" version="1">MADREQPYDPYIPAGGNAPQGGAQGQSGNHRTAALQAEIDSTVGIMRDNINKVSERGARLDSLQDKTDNLATSAQGFRRGANRVRKQMWWKDMKMRMCLIVGIIILLIVIIVPSVIATKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CBQ4</accession>
    <name>A0A177CBQ4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1219412</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG04207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034572.1">
        <property type="nucleotide sequence ID" value="XM_018183078.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CBQ4"/>
    <dbReference type="STRING" id="1460663.A0A177CBQ4"/>
    <dbReference type="GeneID" id="28766564"/>
    <dbReference type="InParanoid" id="A0A177CBQ4"/>
    <dbReference type="OrthoDB" id="2820488at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008057989" evidence="1">
        <location>
            <begin position="20"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG04207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="166" mass="18420" checksum="EF19E05A7F8D009E" modified="2016-09-07" version="1">MRLLTFLAVAIVAPIVGLAAPASEAPSYARGENLCSQYKSPPKLCTPDPTVTVEETAKRAYQFYKAFVIDGDARTMFSLIDNSYIQHHPGYANGPQAIWSLFCNGKPVGSASGSSWCFDASTNMSYAQYSTTDRWRWVDGCVHEHWDSGEKIPKDKCYKLNTTSIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CBT9</accession>
    <name>A0A177CBT9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase</fullName>
            <ecNumber evidence="5">2.7.8.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">GlcNAc-1-P transferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">N-acetylglucosamine-1-phosphate transferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">CC84DRAFT_1166326</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. Catalyzes the initial step of dolichol-linked oligosaccharide biosynthesis, transfering GlcNAc-1-P from cytosolic UDP-GlcNAc onto the carrier lipid dolichyl phosphate (P-dolichol), yielding GlcNAc-P-P-dolichol embedded in the cytoplasmic leaflet of the endoplasmic reticulum membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>a di-trans,poly-cis-dolichyl phosphate + UDP-N-acetyl-alpha-D-glucosamine = an N-acetyl-alpha-D-glucosaminyl-diphospho-di-trans,poly-cis-dolichol + UMP</text>
            <dbReference type="Rhea" id="RHEA:13289"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19507"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:58427"/>
            <dbReference type="EC" id="2.7.8.15"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:13290"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyltransferase 4 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.15" evidence="5"/>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG04237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034602.1">
        <property type="nucleotide sequence ID" value="XM_018178931.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CBT9"/>
    <dbReference type="FunCoup" id="A0A177CBT9">
        <property type="interactions" value="510"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CBT9"/>
    <dbReference type="GeneID" id="28762417"/>
    <dbReference type="InParanoid" id="A0A177CBT9"/>
    <dbReference type="OrthoDB" id="10262326at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043541">
        <property type="term" value="C:UDP-N-acetylglucosamine transferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003975">
        <property type="term" value="F:UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009060">
        <property type="term" value="P:aerobic respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd06855">
        <property type="entry name" value="GT_GPT_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000715">
        <property type="entry name" value="Glycosyl_transferase_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033895">
        <property type="entry name" value="GPT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10571">
        <property type="entry name" value="UDP-N-ACETYLGLUCOSAMINE--DOLICHYL-PHOSPHATE N-ACETYLGLUCOSAMINEPHOSPHOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10571:SF0">
        <property type="entry name" value="UDP-N-ACETYLGLUCOSAMINE--DOLICHYL-PHOSPHATE N-ACETYLGLUCOSAMINEPHOSPHOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00953">
        <property type="entry name" value="Glycos_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 20" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="35"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="170"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="211"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="239"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="270"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="301"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="426"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00017659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00029567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00033238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00044717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00045078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="OAG04237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="459" mass="51076" checksum="95B9776F61FA8D97" modified="2016-09-07" version="1">MSTALSSTEAYSLLSLSLAAVGVLLNTFTGEGEPLIASIAFSCLAFSSCYALIRWLGNAFIRRGFKGKDLCKLKQTEIPETMGAVCAMVYLFTIITFIPWPFYKDIVVATSGGGNRDVIKELEEVETGRLLHRFPHNKLASYLSAILSLQTIVLLGIGDDLFDIRWRHKVFIPAVAAIPMLIVYFVDFGVTQMVVPIPLRPYLGELFDLGWLYYAYMALLSIFSSNSINILAGINGIEVAQSLVIAVLIVANDVLYLSPFTAYPHPATDSHLFSLYLLLPFIGVSLALLKHNWFPAKVFVGDTYCYFAGMVFAVDGILGHFSKTLILLLLPQGFNFIYSAPQLFHIVPCPRHRLPHFNARTGLLECSRVEFKKPLARPVAEGLKVLHRLRLLDVETDENGQVVSSSNFTLINLWLVWFGPMREDRLALGLLAFQTAVGVAGLLVRHRMALLVFTADNWY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CBX9</accession>
    <name>A0A177CBX9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1247950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG05173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035538.1">
        <property type="nucleotide sequence ID" value="XM_018184244.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CBX9"/>
    <dbReference type="GeneID" id="28767730"/>
    <dbReference type="InParanoid" id="A0A177CBX9"/>
    <dbReference type="OrthoDB" id="3769170at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="367"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="231"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="256"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="292"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG05173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="388" mass="43586" checksum="C35BA1459F008A03" modified="2016-09-07" version="1">MGFPRNFREHSRNVSAPAKAPNMPLRHGKRPSVVDGKVLEPEWDRVPQTYGSFNQDTLARISQVQAEHARTARPTTQLPHSQRPPPENPPQSSCLNYSACMDSASPRQPFKRYYSSALSDEDRTALAVGELNHNLRGWTGDKLVQYHVSRIELVPYSEERQEIIAEILDEKRGGERFVLQSARQAKRFVSSPLSKLQTFKEVKTHNEQMQVEASRSMVDLRAANTSSLLLSPISPISPVSPPSSTSQEGFPFPVLETQNIRQSTHSGASSNGDHFSRQSVSSSMMQFPHTSDSSRDSSHNRGHAPDRRPLVRRADRNTSRFRSSMALEAIHYVVNADITFDTFLAPHASGKGETHCDSVHIKKEVQPRNFSRRLSKMPSMPQLKKRAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CC53</accession>
    <name>A0A177CC53_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_790744</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG04367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034732.1">
        <property type="nucleotide sequence ID" value="XM_018187399.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CC53"/>
    <dbReference type="GeneID" id="28770885"/>
    <dbReference type="InParanoid" id="A0A177CC53"/>
    <dbReference type="OrthoDB" id="3935170at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG04367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="96" mass="10367" checksum="8DF62217DA0B45B7" modified="2016-09-07" version="1">MPSLPFNSASSSPSSSPTLSPSPPAIVLHSASGQASKRELYKSNEDKSAAYRQRYAQYLASTFNMSIEAARAEADIQLAPRRSSGVSESEMLRDGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CCK4</accession>
    <name>A0A177CCK4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Tat pathway signal sequence</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CC84DRAFT_1217982</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Mycotoxin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ustYa family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG04537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034902.1">
        <property type="nucleotide sequence ID" value="XM_018182950.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CCK4"/>
    <dbReference type="STRING" id="1460663.A0A177CCK4"/>
    <dbReference type="GeneID" id="28766436"/>
    <dbReference type="InParanoid" id="A0A177CCK4"/>
    <dbReference type="OrthoDB" id="3687641at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021765">
        <property type="entry name" value="UstYa-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365:SF11">
        <property type="entry name" value="TAT PATHWAY SIGNAL SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365">
        <property type="entry name" value="YALI0B05434P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11807">
        <property type="entry name" value="UstYa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="37"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="22"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00035112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAG04537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="225" mass="25661" checksum="901CD96C82BBD4C6" modified="2016-09-07" version="1">MWFEKSRNEQDHRYAPIDLTAEDQSQHPPRTASSLPWIYIITTTCIVTIVAVVSFFAGTSFARREKYWRPDLPTVQKALQPDTSFMVQPNNVDDHTWDSMFPSSTFFPHPDIAPERGTLSVFHQLHCLNAIRHIYWATVDPNHHKRDGAGPGDPAFDKWHMNHCIELLRQSLMCNADLTLEVTNKTLGGVTGFGTKHVCVDWEGLLKWVDETEENAIDHAVSTHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CCL4</accession>
    <name>A0A177CCL4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Pre-mRNA-splicing factor CWC24</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CC84DRAFT_1164968</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 8">Involved in pre-mRNA splicing.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 8">Associated with the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the CWC24 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG04518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034883.1">
        <property type="nucleotide sequence ID" value="XM_018178612.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CCL4"/>
    <dbReference type="STRING" id="1460663.A0A177CCL4"/>
    <dbReference type="GeneID" id="28762098"/>
    <dbReference type="InParanoid" id="A0A177CCL4"/>
    <dbReference type="OrthoDB" id="25761at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005684">
        <property type="term" value="C:U2-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034247">
        <property type="term" value="P:snoRNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16539">
        <property type="entry name" value="RING-HC_RNF113A_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000045">
        <property type="entry name" value="RING finger protein 113A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039971">
        <property type="entry name" value="CWC24-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12930:SF0">
        <property type="entry name" value="RING FINGER PROTEIN 113B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12930">
        <property type="entry name" value="ZINC FINGER PROTEIN 183"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="6 7 8" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 7 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="11">
        <location>
            <begin position="153"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="10">
        <location>
            <begin position="233"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="7">
        <location>
            <begin position="153"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="10"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU367110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OAG04518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="314" mass="34192" checksum="4F45C03BD352AB8A" modified="2016-09-07" version="1">MADTEVPVVKFKKRGAKAAPRKAAPPPPRSDSDSSDSDGEGDDGRVVKRRKVNEHALKASTADQQTPRTALEGTTKYEANRAAVIEATDDATKASNWYENDHASDALSSKSLLGSTRILAKPQSLIEKDANAPERKVGPQKSSSNVRTITMVDYTPDVCKDYKQTGFCGFGDGCKFLHAREDYAAGWKLDKEWETSNKGKKPGGTVVASANRDGKKDEDGIDLSMLEKIPFACIICKQPYKSPIITKCGHYFCEACALKRYRKDPTCANCSAKTYGVFNGAKNLQKLLAKKQEWEDKKKAEAEAEAAEKGEGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CDA6</accession>
    <name>A0A177CDA6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cytochrome P450 monooxygenase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CC84DRAFT_1148615</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Mycotoxin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG05296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035661.1">
        <property type="nucleotide sequence ID" value="XM_018176644.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CDA6"/>
    <dbReference type="STRING" id="1460663.A0A177CDA6"/>
    <dbReference type="GeneID" id="28760130"/>
    <dbReference type="InParanoid" id="A0A177CDA6"/>
    <dbReference type="OrthoDB" id="1844152at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11041">
        <property type="entry name" value="CYP503A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206:SF7">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0349">Heme</keyword>
    <keyword evidence="6 7 8" id="KW-0408">Iron</keyword>
    <keyword evidence="4 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="453"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAG05296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="510" mass="57601" checksum="7859FC536D0D3229" modified="2016-09-07" version="1">MEVQGFQSLVHSAQTVAIAALIFVACYYLPRLNFKAQVAKLPAFAEGGEKQRNEFLKNGKSMYLQGYEKFKNQVFRMTGSDGDETIVISPQFLPELRKLPDTVVSFPKAVADLMEVKYTGLLADEPLGVHAVRADLTPALARLNPVVYSEVLQALEEIMPTCEDWTAVNIYSKLVSMVAMITGRVLVGPDLCRDEEYQRLSIEYTMQLITAQLEIKKIRPLFKPWSAPRLDSVKKLQASRKNLANFLEPIIQARRDAEKNEPEWQKPDDMVTWLMSREGEFGVKSTHHLAQIVLGLIFASIHTTTLTATNILYTLAVQTEYIEPIREEVRQVMNENGGTISTRALQQMMKLDSYMKESMRFYPPGFTSFQRKVTRGFTLSNGQYIPAGVKIEVASHAVYQDPANYSNPEPADVFDGFRAYKLRQGGTATNHARNQFVTTNEQNLMFGYGKHACPGRFFAANEIKMILANLILNYDFKNEDGSKERYAQLDVGRQSSPDARKNLLFKAVTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CDK1</accession>
    <name>A0A177CDK1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RTA1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CC84DRAFT_1196074</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG05724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036089.1">
        <property type="nucleotide sequence ID" value="XM_018181436.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CDK1"/>
    <dbReference type="FunCoup" id="A0A177CDK1">
        <property type="interactions" value="37"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CDK1"/>
    <dbReference type="GeneID" id="28764922"/>
    <dbReference type="InParanoid" id="A0A177CDK1"/>
    <dbReference type="OrthoDB" id="4521223at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007568">
        <property type="entry name" value="RTA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465:SF9">
        <property type="entry name" value="SPHINGOID LONG-CHAIN BASE TRANSPORTER RSB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04479">
        <property type="entry name" value="RTA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="41"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="140"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="175"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="228"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="266"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAG05724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="322" mass="35772" checksum="DE02BBC9ECAD5CE5" modified="2016-09-07" version="1">MGASSDFVPAKNGTAAAKPKAGVRPLDKAIITYYPNFAGNTIYGVCFIILLFMQLFFGIHKKTWTYMSAVCLGIFGEIVGYGGRLMLNNNPFDMNNFLVYLVPLTVAPALLTGGIYLCLSRVIVAVGADYSRIKPKMYTYIFVGCDLLSLVLQSIGGAIASMARNTSSRDLGVHIMIAGLISQIISMIIFFALWGDFAFRVRKAKSAGNLTGQAPLYESLRADPSFRWFQWSLFVATLLIFIRSVYRVAELWGGFQSHLANDEVTFMIFEGPMIIVAVMMMTAFHPGRIFDDLWIPAGKGYRFFKHGDTGSTDKIELIERNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CE37</accession>
    <name>A0A177CE37_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1165506</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG05182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035547.1">
        <property type="nucleotide sequence ID" value="XM_018178727.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CE37"/>
    <dbReference type="GeneID" id="28762213"/>
    <dbReference type="InParanoid" id="A0A177CE37"/>
    <dbReference type="OrthoDB" id="2532734at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="37"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG05182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="81" mass="8318" checksum="A61B887A32046008" modified="2016-09-07" version="1">MPVHPAEENATGSITDQVAKESSDSNASTHQHHDVDTGASSGGSTASAMAHKGAPGPVQAENIGEPASKEELKKRAEELNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CEW0</accession>
    <name>A0A177CEW0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1177343</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG05270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035635.1">
        <property type="nucleotide sequence ID" value="XM_018180278.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CEW0"/>
    <dbReference type="GeneID" id="28763764"/>
    <dbReference type="InParanoid" id="A0A177CEW0"/>
    <dbReference type="OrthoDB" id="3734244at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG05270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="180" mass="19230" checksum="11510ED101689BF8" modified="2016-09-07" version="1">MKISGTECTPPAPRTFNTDQGYRLPASRIGLKRENRVSTSSVALPQTITLAPARAHTIPSFASFISHNQPSSMFALFSKIQDDQPEEDESAPATPPTRDDTSKTSLPGRVASPKKATAQIDPVDGKTKTCDRGRTFETFVDVGKLTADLGVTEAVGSSSDARRGLGKVRGWVGRRKGPGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CF36</accession>
    <name>A0A177CF36_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CC84DRAFT_1092618</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG05811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036176.1">
        <property type="nucleotide sequence ID" value="XM_018174471.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CF36"/>
    <dbReference type="STRING" id="1460663.A0A177CF36"/>
    <dbReference type="GeneID" id="28757957"/>
    <dbReference type="InParanoid" id="A0A177CF36"/>
    <dbReference type="OrthoDB" id="654211at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051059">
        <property type="entry name" value="VerF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626:SF10">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626">
        <property type="entry name" value="MIP31509P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="8">
        <location>
            <begin position="169"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="79"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAG05811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="669" mass="75536" checksum="3B6DAC0E7CEA5449" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CFQ7</accession>
    <name>A0A177CFQ7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Polyprenal reductase</fullName>
            <ecNumber evidence="5">1.3.1.94</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CC84DRAFT_1164699</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Plays a key role in early steps of protein N-linked glycosylation by being involved in the conversion of polyprenol into dolichol. Acts as a polyprenal reductase that mediates the reduction of polyprenal into dolichal in a NADP-dependent mechanism. Dolichols are required for the synthesis of dolichol-linked monosaccharides and the oligosaccharide precursor used for N-glycosylation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a di-trans,poly-cis-dolichal + NADP(+) = a di-trans,poly-cis-polyprenal + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:80727"/>
            <dbReference type="Rhea" id="RHEA-COMP:19536"/>
            <dbReference type="Rhea" id="RHEA-COMP:19537"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:231623"/>
            <dbReference type="ChEBI" id="CHEBI:231637"/>
            <dbReference type="EC" id="1.3.1.94"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="5">
            <dbReference type="Rhea" id="RHEA:80729"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the steroid 5-alpha reductase family. Polyprenal reductase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.94" evidence="5"/>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG06433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036798.1">
        <property type="nucleotide sequence ID" value="XM_018178539.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CFQ7"/>
    <dbReference type="FunCoup" id="A0A177CFQ7">
        <property type="interactions" value="350"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CFQ7"/>
    <dbReference type="GeneID" id="28762025"/>
    <dbReference type="InParanoid" id="A0A177CFQ7"/>
    <dbReference type="OrthoDB" id="541710at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003865">
        <property type="term" value="F:3-oxo-5-alpha-steroid 4-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160198">
        <property type="term" value="F:polyprenal reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102389">
        <property type="term" value="F:polyprenol reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016095">
        <property type="term" value="P:polyprenol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001104">
        <property type="entry name" value="3-oxo-5_a-steroid_4-DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039698">
        <property type="entry name" value="Dfg10/SRD5A3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14624">
        <property type="entry name" value="DFG10 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14624:SF0">
        <property type="entry name" value="POLYPRENOL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02544">
        <property type="entry name" value="Steroid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50244">
        <property type="entry name" value="S5A_REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="3-oxo-5-alpha-steroid 4-dehydrogenase C-terminal" evidence="6">
        <location>
            <begin position="177"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU367081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAG06433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="291" mass="32488" checksum="F08018234F8A0169" modified="2016-09-07" version="1">MDAAMDWLGLLLTPAAVRAFYLAASVLVLVIQATPALRIRFLAYGSRATAAQPAQTCPPNGLERLLDYVASFQVPHNYFTHFYVVSVASSLLWGWKLRLWDAGGQLPVLWALMLLQGVRRLVESHAYTSSSNSTMWFAHWILGLLFYLATNVAVWVDLQADIGPHRESYPAALSWKTATFAPAVLTAQALQHVYHAYLYRLRTQNNGYQLPSHPLFPDLLCPHYTCDIAVYVLLSFLGAPTGCPINWTLASAALFTAVNLGVTAAGTKDWYAQRFGKDKVSARRRMIPWLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CFW6</accession>
    <name>A0A177CFW6_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_730177</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG05620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035985.1">
        <property type="nucleotide sequence ID" value="XM_018187202.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CFW6"/>
    <dbReference type="STRING" id="1460663.A0A177CFW6"/>
    <dbReference type="GeneID" id="28770688"/>
    <dbReference type="InParanoid" id="A0A177CFW6"/>
    <dbReference type="OrthoDB" id="442087at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052758">
        <property type="entry name" value="SRC_co-chaperone"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44200">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44200:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="6"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG05620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="254" mass="29021" checksum="FB4AA403263068BB" modified="2016-09-07" version="1">MDTVTTHYDTLGVTQAAAPAVIRGAYKALALLHHPDKTLRLPAEDRATHSSLFRSAQEAFDVLNNPSAKAAYDRKLQRASRSNSHSHVHSPTTSRRPNTIHVTSPEEKRALKVKIEQDIAYLRERRAKRDLEDAHMDIAALKFMAQTDAEMAAKYDEDALGHGHSRAYRATQMQVYLEKIEKRERKHEGWLENMARPRAPGMKPERPPTSYNIRTAAPSPKPAYNVRTATPMPKPANMEEYTWISFEPFWLYQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CG58</accession>
    <name>A0A177CG58_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nonribosomal peptide synthetase 12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1241156</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG06583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036948.1">
        <property type="nucleotide sequence ID" value="XM_018184047.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CG58"/>
    <dbReference type="GeneID" id="28767533"/>
    <dbReference type="InParanoid" id="A0A177CG58"/>
    <dbReference type="OrthoDB" id="3142841at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052979">
        <property type="entry name" value="Adenylate-forming_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33927:SF5">
        <property type="entry name" value="ENZYME, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G01222)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33927">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="205"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="244"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="282"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG06583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="511" mass="56963" checksum="1179DCF59EB266CB" modified="2016-09-07" version="1">MEAKISRKSAVASSPEVEGAARAQIQQLLYQPFSSTLAPDSIMNVVEESTVGFVIGEVELGHVKEAVELPKQWGNSFLHKLRYAWASSYRKTFALIFTVNLAVFVALVATAENGRPKHRDIGTAASANLVAAILFRQENFLNILYEVFARAPHSWPLCIRKRLAKVFHYGGVHSSCGVAAVIWYILYTVEATILLIEDKNAHSDILANMVTSWVLVTMFIVVLVGAHPSFRRRYHDYFEAFHRFAGWTALVNFWVHNVFSAAITARETGNTTGMALLETPSFWTILISTGCTLLSWSRLRLRKVYPEKLSNHATRLHFRYAGMPCFYGVKLSDRPLLEWHAFATIPDVDEATGTTTGFSVVVSNAGDWTNKQIMDSGERKLWIRGNPLHGLLYTSRLFKKIVLVATGSGIGPCLSLMHANITPTRIYWSTRDPQKNYGDAVVHAVRKADPRAVIWNTSTQGRGIMIQSVYELVKESDAEAVFIISNPKVTDLVVFGMQSRGVPAYGAIFDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CHM2</accession>
    <name>A0A177CHM2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Aldolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CC84DRAFT_1164566</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DapA family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG06257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036622.1">
        <property type="nucleotide sequence ID" value="XM_018178511.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CHM2"/>
    <dbReference type="STRING" id="1460663.A0A177CHM2"/>
    <dbReference type="GeneID" id="28761997"/>
    <dbReference type="InParanoid" id="A0A177CHM2"/>
    <dbReference type="OrthoDB" id="191315at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008840">
        <property type="term" value="F:4-hydroxy-tetrahydrodipicolinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00408">
        <property type="entry name" value="DHDPS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002220">
        <property type="entry name" value="DapA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128">
        <property type="entry name" value="DIHYDRODIPICOLINATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128:SF24">
        <property type="entry name" value="DIHYDRODIPICOLINATE SYNTHETASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_3G11920)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00701">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001365">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00146">
        <property type="entry name" value="DHPICSNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01130">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="2">
        <location>
            <position position="162"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="2">
        <location>
            <position position="191"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="241"/>
        </location>
        <ligand>
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR001365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR001365-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001365-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAG06257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="332" mass="35231" checksum="FC91BA983CB978D4" modified="2016-09-07" version="1">MASGAVNGHANGTNGQARERTPLRPGIYSPTMTFFDPETEEVDIPTVKKHAVRLAEAGLVGLVTMGSNGEAVHLNRAEKAAITRATREALDEAGYQNVPVIAGASEHGIKLTIESCKDAAEAGAEYVLLVPPSYYRYAIDEDAIVEYYTKVADASPLPVILYNYPGAVSGIDMDSDLIIKLAEHPNIVGTKFTCGNTGKLTRVALATNAVTFKSNGSGYMAFGGMADFTAQTAASGGSGIIAGGANVIPKTCVKVWNLWAEGKYTEAFELQKVLSKGDWVLTKAAIPGTKSAIQSYYGYGGYPRRPLKRLSDEKVKAVADGIAEVMKVEKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CIM5</accession>
    <name>A0A177CIM5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">GET1</name>
        <name evidence="12" type="ORF">CC84DRAFT_1163561</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the WRB/GET1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG07363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037728.1">
        <property type="nucleotide sequence ID" value="XM_018178292.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CIM5"/>
    <dbReference type="STRING" id="1460663.A0A177CIM5"/>
    <dbReference type="GeneID" id="28761778"/>
    <dbReference type="InParanoid" id="A0A177CIM5"/>
    <dbReference type="OrthoDB" id="69461at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043529">
        <property type="term" value="C:GET complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043495">
        <property type="term" value="F:protein-membrane adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071816">
        <property type="term" value="P:tail-anchored membrane protein insertion into ER membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.660:FF:000006">
        <property type="entry name" value="Protein GET1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.660">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03113">
        <property type="entry name" value="Get1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028945">
        <property type="entry name" value="Get1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027538">
        <property type="entry name" value="Get1_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029012">
        <property type="entry name" value="Helix_hairpin_bin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42650:SF1">
        <property type="entry name" value="GUIDED ENTRY OF TAIL-ANCHORED PROTEINS FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42650">
        <property type="entry name" value="TAIL-ANCHORED PROTEIN INSERTION RECEPTOR WRB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04420">
        <property type="entry name" value="CHD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008058209" evidence="11">
        <location>
            <begin position="24"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="topological domain" description="Lumenal" evidence="9">
        <location>
            <begin position="1"/>
            <end position="4"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="9">
        <location>
            <begin position="173"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="198"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OAG07363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="218" mass="24067" checksum="EC4EA06866A175E1" modified="2016-09-07" version="1">MPSLLLVMFVLQTVLHIINTVGASTINELLWVLYNKLPTPTSSSAQRVQILKREIVRLKRELAATSPQDNFSGWAKLDRQHNKATAEYQKLDASLRTHQTTFTSTVSTLRWLGTQGARFLLQMYFAKSPMFWVPAGWVPYYVEWILSFPRAPLGSVSINVWGIACASMLALVSEAVAASYVLATKKAVPVGEKKGEPMAFEAQPKGGAGKGAAREKEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CIP5</accession>
    <name>A0A177CIP5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_1186358</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG07383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037748.1">
        <property type="nucleotide sequence ID" value="XM_018180854.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CIP5"/>
    <dbReference type="STRING" id="1460663.A0A177CIP5"/>
    <dbReference type="GeneID" id="28764340"/>
    <dbReference type="InParanoid" id="A0A177CIP5"/>
    <dbReference type="OrthoDB" id="2735536at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000426">
        <property type="entry name" value="Aldehyde reductase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050425">
        <property type="entry name" value="NAD(P)_dehydrat-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366:SF562">
        <property type="entry name" value="ALDEHYDE REDUCTASE II (AFU_ORTHOLOGUE AFUA_1G11360)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366">
        <property type="entry name" value="NAD DEPENDENT EPIMERASE/DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="3">
        <location>
            <begin position="10"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAG07383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="359" mass="39624" checksum="E04B896C05D414EE" modified="2016-09-07" version="1">MAAISKGSLVFVTGVSGLIGSHVADHLLRAGFRVRGAVRSEQEATMMHEIYKGRHPKAIDLFQTVVITDMKLPGAFTGHLAGCEGIAHVASDLSFSPDPNVVITGCVNGVISLLNEAKSTPSIKRFVYTSSSNAATRPLVGESRHVDSSSWNDDILEEAWAPPPFETSRSYAVYAASKVACERAAWTFVSDQKPQFTFNTVLPNYTSGIVLQPLSIPGAGSTARWVRDVYDHPFEEEFVAKLRDDSPAWQVEVEDVAKLHLAALCHGDVVGERLFGFAHKFNYNSFLKVFRELAPERKWPEDRNGLEWPSTIVNNERSIELLRRFGADGWTSFHESVRRSCLSQYGEGFTPFDGVVPGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CJ89</accession>
    <name>A0A177CJ89_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1163293</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG07042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037407.1">
        <property type="nucleotide sequence ID" value="XM_018178225.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CJ89"/>
    <dbReference type="GeneID" id="28761711"/>
    <dbReference type="InParanoid" id="A0A177CJ89"/>
    <dbReference type="OrthoDB" id="5313204at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG07042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="118" mass="13480" checksum="8479F09B8E41EB73" modified="2016-09-07" version="1">MSSTMDKLKDKLHIRRKSQSEEAAFPSGSHASDVQRESFDEELAALPLEEREAYLKEFEEADKVGEHKKGGLIDRCEFDLLRSPSYVLSFSTALCRSLEARYTKVMCMRASRADTRTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CJ92</accession>
    <name>A0A177CJ92_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Eukaryotic translation initiation factor 4E</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CC84DRAFT_1163186</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">eIF4F is a multi-subunit complex, the composition of which varies with external and internal environmental conditions. It is composed of at least eIF4A, eIF4E and eIF4G. eIF4E is also known to interact with other partners.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the eukaryotic initiation factor 4E family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG06890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037255.1">
        <property type="nucleotide sequence ID" value="XM_018178201.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CJ92"/>
    <dbReference type="FunCoup" id="A0A177CJ92">
        <property type="interactions" value="1228"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CJ92"/>
    <dbReference type="GeneID" id="28761687"/>
    <dbReference type="InParanoid" id="A0A177CJ92"/>
    <dbReference type="OrthoDB" id="590761at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016281">
        <property type="term" value="C:eukaryotic translation initiation factor 4F complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000340">
        <property type="term" value="F:RNA 7-methylguanosine cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.760.10:FF:000004">
        <property type="entry name" value="Eukaryotic translation initiation factor 4E-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.760.10">
        <property type="entry name" value="RNA Cap, Translation Initiation Factor Eif4e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023398">
        <property type="entry name" value="TIF_eIF4e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001040">
        <property type="entry name" value="TIF_eIF_4E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019770">
        <property type="entry name" value="TIF_eIF_4E_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11960">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11960:SF8">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01652">
        <property type="entry name" value="IF4E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55418">
        <property type="entry name" value="eIF4e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00813">
        <property type="entry name" value="IF4E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 10" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="6 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0810">Translation regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00062860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAG06890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="256" mass="28684" checksum="05C3A3A7234054A8" modified="2016-09-07" version="1">MADVATAPNPNQQVPLDTIPISPSDETSSESKEPGSTAATSDGDIRTVFHDPENFNVKHPLMNTWTLWFTKPPSGKGDNWNELLKEVISFDSVEEFWGIYNNITPTSDLALKSDYHLFKQGVRPEWEDAQNKHGGKWAFQFKDKKAVNIDALWLHVMLAAIGENLEDEDDNEVMGVVVNVRRGFYRIGLWTRTVGKALPNDQNKGRSFEQGKETLSKIGKRFKQALQLKENDPVEFSGHTDAAHAGSTRAKAKFVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CJR2</accession>
    <name>A0A177CJR2_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">LysM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CC84DRAFT_1163282</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG07027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037392.1">
        <property type="nucleotide sequence ID" value="XM_018178222.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CJR2"/>
    <dbReference type="STRING" id="1460663.A0A177CJR2"/>
    <dbReference type="GeneID" id="28761708"/>
    <dbReference type="InParanoid" id="A0A177CJR2"/>
    <dbReference type="OrthoDB" id="2281372at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052210">
        <property type="entry name" value="LysM1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34997">
        <property type="entry name" value="AM15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34997:SF1">
        <property type="entry name" value="PEPTIDOGLYCAN-BINDING LYSIN DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0843">Virulence</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008058252" description="LysM domain-containing protein" evidence="3">
        <location>
            <begin position="20"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="4">
        <location>
            <begin position="57"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAG07027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="192" mass="20764" checksum="C4409278482919EA" modified="2016-09-07" version="1">MVSFTLTAGIALLVSAAAAIPTQSLVARQATLPDECSDYCSVSAGCVCIRRPTNCVANYLVQSGDNCGTIVSQYNNFTAHDLLAWNPEIGKECFGLRAYVPVCIGVPGYTYPGPVKGGDIWTPEEIPVPVMPGIVANCSKFEYTDKTGVPTLANILAENQISKQQWNSWNVPTQDSEQDWAVWAQYFSCVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CMR3</accession>
    <name>A0A177CMR3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1214751</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038597.1">
        <property type="nucleotide sequence ID" value="XM_018182667.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CMR3"/>
    <dbReference type="GeneID" id="28766153"/>
    <dbReference type="InParanoid" id="A0A177CMR3"/>
    <dbReference type="OrthoDB" id="3769987at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="254"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="279"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG08232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="501" mass="56345" checksum="661FF58E8455321E" modified="2016-09-07" version="1">MSKAGASSRVRAPGSMDPVTYGKATRQIIFEKSINPGWAPYNQHIRRALGFREKNAGGKGRPVFASENVNQLYGELDDMAKKLPNHSQQELKRAWEKQTYTKDVRRLVDNYGEKIWGDSLKDRELSSNPKSQLLTAEDGSEAGNLFYQYERHRKFITLQLEHLLFMKAIAVYHNYHGPSAPRSAAESRPVSTRSTRPGASKPRKRSSSVARYIFTFRLPSDKMRAVLCRTSKRIAEKKRARDAAGRLLYEVTGESDNEWTPTKRRRPSQRYPRLSASDVTDDDSSASEQSVEGDESSTAGRNGSDGALVVGPVSEEVKRSMRMDMAVSLYSELCHEDDGSHNKLPDANSMLVASKRLDNVIHTLRRQDEDKLRKSLGGSFQQDLRTLDAWLSWREGCWLLSEATGIHPFGGQPTPRFTVGQWNNMFGGGEKCRRIHQTLLKCGQIALGIHDGKDEKTLSTASSLARVFAAMAESPMLEQSLPNHIVAHNKLLSSWKMDFWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CNQ4</accession>
    <name>A0A177CNQ4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_584086</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038977.1">
        <property type="nucleotide sequence ID" value="XM_018186771.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CNQ4"/>
    <dbReference type="FunCoup" id="A0A177CNQ4">
        <property type="interactions" value="757"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CNQ4"/>
    <dbReference type="GeneID" id="28770257"/>
    <dbReference type="InParanoid" id="A0A177CNQ4"/>
    <dbReference type="OrthoDB" id="8093034at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12614">
        <property type="entry name" value="RRM1_PUB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12619">
        <property type="entry name" value="RRM2_PUB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12622">
        <property type="entry name" value="RRM3_PUB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000117">
        <property type="entry name" value="Nuclear and cytoplasmic polyadenylated RNA-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000224">
        <property type="entry name" value="Nuclear and cytoplasmic polyadenylated RNA-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000134">
        <property type="entry name" value="Nuclear and cytoplasmic polyadenylated rna-binding pub1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003954">
        <property type="entry name" value="RRM_euk-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48038">
        <property type="entry name" value="RIBONUCLEOPROTEIN RB97D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48038:SF1">
        <property type="entry name" value="RIBONUCLEOPROTEIN RB97D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00361">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="88"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="191"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="317"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="386"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="49"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="403"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="462"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="473"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAG08612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="497" mass="53634" checksum="D0AE9392DD94CA61" modified="2016-09-07" version="1">MADAQAAQSQMQPPSASAGAPGYDGGAPGQGQPQQHMPPPPLAPVIIPQNTNPIPTAISSPMSGNPMSPTSGGAGYVPRRAAPEPNKRALYVGGLDPRVTEDVLRQIFETTGHVQSVKIIPDKNVSAVETNIGVQFSQKGFNYGFVEFDDPAAAERAMQTLNGRRVHNNEIRVNWAYQSNNTAKEDTSNHFHIFVGDLSNEVNDEVLLQAFSTFGPVSEARVMWDMKTGRSRGYGFVAFRDRADAERALSSMDGEWLGSRAIRCNWANQKGQPSISQQQAMASMGMTPTTPFGHHHFPTHGVQSYDMVVQQTPQWQTTCYVGNLTPYTSQSDLVPLFQNFGYVTETRFQSDRGFAFIKMDTHENAAMAICQLNGYNVNGRPLKCSWGKDRPPTGQFDGYSPQAGPNSAYPQTPSQYFPQYGAGPGGPMSPQGPSPGGQPFAQNQAGFGGPGMAQPYQQMPGSAGGYNAGRGGQPPQQQWGQQPQGNFNQNGFGGYQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CNY3</accession>
    <name>A0A177CNY3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">L-lactate dehydrogenase (cytochrome)</fullName>
            <ecNumber evidence="15">1.1.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CC84DRAFT_1194673</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>(S)-lactate + 2 Fe(III)-[cytochrome c] = 2 Fe(II)-[cytochrome c] + pyruvate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:19909"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16651"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.1.2.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:19910"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">In the C-terminal section; belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="14">In the N-terminal section; belongs to the cytochrome b5 family.</text>
    </comment>
    <dbReference type="EC" id="1.1.2.3" evidence="15"/>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038874.1">
        <property type="nucleotide sequence ID" value="XM_018181359.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CNY3"/>
    <dbReference type="FunCoup" id="A0A177CNY3">
        <property type="interactions" value="337"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CNY3"/>
    <dbReference type="GeneID" id="28764845"/>
    <dbReference type="InParanoid" id="A0A177CNY3"/>
    <dbReference type="OrthoDB" id="1925334at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004460">
        <property type="term" value="F:L-lactate dehydrogenase (cytochrome) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006089">
        <property type="term" value="P:lactate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02922">
        <property type="entry name" value="FCB2_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000062">
        <property type="entry name" value="Cytochrome b2, mitochondrial, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000012">
        <property type="entry name" value="Mitochondrial cytochrome b2, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000262">
        <property type="entry name" value="FMN-dep_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037396">
        <property type="entry name" value="FMN_HAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008259">
        <property type="entry name" value="FMN_hydac_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037458">
        <property type="entry name" value="L-MDH/L-LDH_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578:SF148">
        <property type="entry name" value="L-LACTATE DEHYDROGENASE (CYTOCHROME)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578">
        <property type="entry name" value="S -2-HYDROXY-ACID OXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01070">
        <property type="entry name" value="FMN_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00363">
        <property type="entry name" value="CYTOCHROMEB5"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00557">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51349">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0288">FMN</keyword>
    <keyword evidence="5" id="KW-0349">Heme</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="17">
        <location>
            <begin position="10"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="FMN hydroxy acid dehydrogenase" evidence="18">
        <location>
            <begin position="113"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00052399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00061137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00061589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00066458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00068515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="OAG08509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="512" mass="57230" checksum="383678C698F56920" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CP59</accession>
    <name>A0A177CP59_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">Cytidine deaminase</fullName>
            <ecNumber evidence="4 13">3.5.4.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 13">Cytidine aminohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CC84DRAFT_1162560</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 13">This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>2'-deoxycytidine + H2O + H(+) = 2'-deoxyuridine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:13433"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15698"/>
            <dbReference type="ChEBI" id="CHEBI:16450"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.4.5"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 13">
            <text>cytidine + H2O + H(+) = uridine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:16069"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16704"/>
            <dbReference type="ChEBI" id="CHEBI:17562"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.4.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 12 13">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the cytidine and deoxycytidylate deaminase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.5" evidence="4 13"/>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039035.1">
        <property type="nucleotide sequence ID" value="XM_018178023.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CP59"/>
    <dbReference type="FunCoup" id="A0A177CP59">
        <property type="interactions" value="165"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CP59"/>
    <dbReference type="GeneID" id="28761509"/>
    <dbReference type="InParanoid" id="A0A177CP59"/>
    <dbReference type="OrthoDB" id="414540at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004126">
        <property type="term" value="F:cytidine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055086">
        <property type="term" value="P:nucleobase-containing small molecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072527">
        <property type="term" value="P:pyrimidine-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01283">
        <property type="entry name" value="cytidine_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000008">
        <property type="entry name" value="Cytidine deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016192">
        <property type="entry name" value="APOBEC/CMP_deaminase_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050202">
        <property type="entry name" value="Cyt/Deoxycyt_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006262">
        <property type="entry name" value="Cyt_deam_tetra"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01354">
        <property type="entry name" value="cyt_deam_tetra"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004064">
        <property type="entry name" value="PRK05578.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11644">
        <property type="entry name" value="CYTIDINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11644:SF2">
        <property type="entry name" value="CYTIDINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00903">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 12 13" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="14">
        <location>
            <begin position="28"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10">
        <location>
            <position position="87"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="74"/>
            <end position="80"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR606262-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR606262-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR606262-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU364006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OAG08670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="185" mass="19736" checksum="A7E546C89498E668" modified="2016-09-07" version="1">MSSQAPVKPVSAEQVNEKDGLIHGVSAAELQSLCTTSLEARGKAYCPYSLFRVGASLLLHTPDASGQTTITGANVENASYPVGTCAERVAMGTAIHQGHKLGSFKAIGVVTDMDDYCSPCGMCRQFLREFLALETPIFMFNKGGKFIVRTMGELLPLSFGPDVLPPKEALRKNLNEAELKGAGVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CP78</accession>
    <name>A0A177CP78_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">FAD monooxygenase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_1195037</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PheA/TfdB FAD monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG09096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039461.1">
        <property type="nucleotide sequence ID" value="XM_018181384.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CP78"/>
    <dbReference type="STRING" id="1460663.A0A177CP78"/>
    <dbReference type="GeneID" id="28764870"/>
    <dbReference type="InParanoid" id="A0A177CP78"/>
    <dbReference type="OrthoDB" id="5325318at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016709">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012941">
        <property type="entry name" value="Phe_hydrox_C_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038220">
        <property type="entry name" value="PHOX_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050641">
        <property type="entry name" value="RIFMO-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004:SF4">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004">
        <property type="entry name" value="TRK SYSTEM POTASSIUM UPTAKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07976">
        <property type="entry name" value="Phe_hydrox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="72"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="domain" description="Phenol hydroxylase-like C-terminal dimerisation" evidence="7">
        <location>
            <begin position="460"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="12"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAG09096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="678" mass="75754" checksum="3E34D88BCE34792D" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CPK1</accession>
    <name>A0A177CPK1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Peroxisomal ATPase PEX6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Peroxin-6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CC84DRAFT_1257860</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">Interacts with PEX1; forming the PEX1-PEX6 AAA ATPase complex, which is composed of a heterohexamer formed by a trimer of PEX1-PEX6 dimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Peroxisome membrane</location>
            <topology evidence="7">Peripheral membrane protein</topology>
            <orientation evidence="7">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG09151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039516.1">
        <property type="nucleotide sequence ID" value="XM_018184769.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A177CPK1">
        <property type="interactions" value="279"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CPK1"/>
    <dbReference type="GeneID" id="28768255"/>
    <dbReference type="InParanoid" id="A0A177CPK1"/>
    <dbReference type="OrthoDB" id="5553750at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016558">
        <property type="term" value="P:protein import into peroxisome matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19527">
        <property type="entry name" value="RecA-like_PEX6_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000108">
        <property type="entry name" value="Peroxisomal biogenesis factor 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000109">
        <property type="entry name" value="Peroxisomal biogenesis factor 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000039">
        <property type="entry name" value="peroxisome biogenesis factor 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050168">
        <property type="entry name" value="AAA_ATPase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056995">
        <property type="entry name" value="PEX6_4th_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047533">
        <property type="entry name" value="RecA-like_PEX6_r2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077">
        <property type="entry name" value="AAA-FAMILY ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077:SF9">
        <property type="entry name" value="PEROXISOMAL ATPASE PEX6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23315">
        <property type="entry name" value="PEX6_4th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23120">
        <property type="entry name" value="PEX6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0962">Peroxisome biogenesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="13">
        <location>
            <begin position="776"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="13">
        <location>
            <begin position="1054"/>
            <end position="1193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="277"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="636"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1317"/>
            <end position="1412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="357"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="644"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1317"/>
            <end position="1327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1328"/>
            <end position="1342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00034691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00062700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OAG09151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="1412" mass="151536" checksum="D0824C4B32316D8A" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CQB2</accession>
    <name>A0A177CQB2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1185770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG09132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039497.1">
        <property type="nucleotide sequence ID" value="XM_018180820.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CQB2"/>
    <dbReference type="STRING" id="1460663.A0A177CQB2"/>
    <dbReference type="GeneID" id="28764306"/>
    <dbReference type="InParanoid" id="A0A177CQB2"/>
    <dbReference type="OrthoDB" id="5366687at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG09132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="202" mass="22667" checksum="F1BE79AEE431D5E5" modified="2016-09-07" version="1">MSTVELIATTLDTAPDSWRDHLQSIRNVTAFLEFSDTHPDESRRQWQLPLMNVFQRVAYADADSGGVSDIGNWCLKQEVTLLHIYPEDIDLLTLIGQNWLHRAQKSLAKIHLSERSSTSSGGSQYVELSASEEDRQTKRSNAEAECRLYMSDYVEARGVLLPAVEYLKHAVDTARTQDKITGELLSTVSRGAHQLQTLIAHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CQC5</accession>
    <name>A0A177CQC5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1142077</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039344.1">
        <property type="nucleotide sequence ID" value="XM_018176349.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CQC5"/>
    <dbReference type="STRING" id="1460663.A0A177CQC5"/>
    <dbReference type="ESTHER" id="9pleo-a0a177cqc5">
        <property type="family name" value="Fungal_carboxylesterase_lipase"/>
    </dbReference>
    <dbReference type="GeneID" id="28759835"/>
    <dbReference type="InParanoid" id="A0A177CQC5"/>
    <dbReference type="OrthoDB" id="3200163at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="1">
        <location>
            <begin position="21"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG08979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="546" mass="60896" checksum="0F93B606E9F10A8D" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CQD9</accession>
    <name>A0A177CQD9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1160393</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG09168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039533.1">
        <property type="nucleotide sequence ID" value="XM_018177487.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CQD9"/>
    <dbReference type="STRING" id="1460663.A0A177CQD9"/>
    <dbReference type="GeneID" id="28760973"/>
    <dbReference type="InParanoid" id="A0A177CQD9"/>
    <dbReference type="OrthoDB" id="2219495at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG09168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="147" mass="16766" checksum="BA24291AFF453C67" modified="2016-09-07" version="1">MTALLRVVCGVDRRPPDVRQGSASSTDINKIVRADYTTPFYMDVAYEAMDAWKTWLVLRNPNGQWFFHQSGWVMLSDEGSDLAERIRTDLRARGSDGTSDLVIDGSVRERWGGLLKNTRFDDPKIEKGYWNPEAKLDGLTLETPWPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CQM6</accession>
    <name>A0A177CQM6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Oxaloacetate Acetylhydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1084632</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate = pyruvate + succinate</text>
            <dbReference type="Rhea" id="RHEA:16809"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:57429"/>
            <dbReference type="EC" id="4.1.3.30"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the isocitrate lyase/PEP mutase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG09200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039565.1">
        <property type="nucleotide sequence ID" value="XM_018174062.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CQM6"/>
    <dbReference type="STRING" id="1460663.A0A177CQM6"/>
    <dbReference type="GeneID" id="28757548"/>
    <dbReference type="InParanoid" id="A0A177CQM6"/>
    <dbReference type="OrthoDB" id="1923844at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046421">
        <property type="term" value="F:methylisocitrate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00377">
        <property type="entry name" value="ICL_PEPM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.60:FF:000009">
        <property type="entry name" value="2-methylisocitrate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039556">
        <property type="entry name" value="ICL/PEPM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018523">
        <property type="entry name" value="Isocitrate_lyase_ph_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42905">
        <property type="entry name" value="PHOSPHOENOLPYRUVATE CARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42905:SF2">
        <property type="entry name" value="PHOSPHOENOLPYRUVATE CARBOXYLASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13714">
        <property type="entry name" value="PEP_mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00161">
        <property type="entry name" value="ISOCITRATE_LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00061405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG09200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="343" mass="37239" checksum="4A23CBAA84BDEC3D" modified="2016-09-07" version="1">MTDERTLAVQLPSHLHIVDKAINAWPASTQWLRLNNSAATTTDEPASGATKLRRMLFETNELIVCPGVYDGLSARTALELGFSGLYMTGAGTTASRLGQPDLAIAQLHEMRENAEMIANLDPFGPPLIADMDTGYGGPIMAARTVEQYIRAGVAGAHLEDQVLQKRCGHLSGKKVVDREEYIARIRAAHAARVRMRSDFVLIARTDALQQYGYDECIARMKMARDEGADVGLVEGFTSKEQAAQAVKDLAPWPLLLNAVENGKSPTLTVDEARVMGFRIMIFSFATLAPAYLAIKETLMRLKTQGIVGTPKNVTPVTLFEVCGLKHSMSVDMNAGGASFKEGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CRK3</accession>
    <name>A0A177CRK3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">dipeptidyl-peptidase IV</fullName>
            <ecNumber evidence="4">3.4.14.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Dipeptidyl peptidase IV</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CC84DRAFT_1111689</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.</text>
            <dbReference type="EC" id="3.4.14.5"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase S9B family.</text>
    </comment>
    <dbReference type="EC" id="3.4.14.5" evidence="4"/>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG09916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040281.1">
        <property type="nucleotide sequence ID" value="XM_018175292.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CRK3"/>
    <dbReference type="STRING" id="1460663.A0A177CRK3"/>
    <dbReference type="GeneID" id="28758778"/>
    <dbReference type="InParanoid" id="A0A177CRK3"/>
    <dbReference type="OrthoDB" id="16520at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000003">
        <property type="entry name" value="Dipeptidyl peptidase 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.140.10.30">
        <property type="entry name" value="Dipeptidylpeptidase IV, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002469">
        <property type="entry name" value="Peptidase_S9B_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050278">
        <property type="entry name" value="Serine_Prot_S9B/DPPIV"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11731:SF162">
        <property type="entry name" value="DIPEPTIDYL PEPTIDASE 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11731">
        <property type="entry name" value="PROTEASE FAMILY S9B,C DIPEPTIDYL-PEPTIDASE IV-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00930">
        <property type="entry name" value="DPPIV_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="10" id="KW-0720">Serine protease</keyword>
    <keyword evidence="8 13" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008058504" description="dipeptidyl-peptidase IV" evidence="13">
        <location>
            <begin position="17"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="domain" description="Dipeptidylpeptidase IV N-terminal" evidence="15">
        <location>
            <begin position="102"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S9 prolyl oligopeptidase catalytic" evidence="14">
        <location>
            <begin position="555"/>
            <end position="751"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OAG09916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="785" mass="88898" checksum="0F1DE0606DB8402F" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CRQ2</accession>
    <name>A0A177CRQ2_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CC84DRAFT_1160926</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG09881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040246.1">
        <property type="nucleotide sequence ID" value="XM_018177619.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CRQ2"/>
    <dbReference type="FunCoup" id="A0A177CRQ2">
        <property type="interactions" value="214"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CRQ2"/>
    <dbReference type="GeneID" id="28761105"/>
    <dbReference type="InParanoid" id="A0A177CRQ2"/>
    <dbReference type="OrthoDB" id="2162761at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051615">
        <property type="entry name" value="Transcr_Regulatory_Elem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313:SF81">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="33"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="649"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="700"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="727"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="656"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="700"/>
            <end position="712"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAG09881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="875" mass="96498" checksum="13D74ED1BADCE6BF" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CSI2</accession>
    <name>A0A177CSI2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1172383</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG09892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040257.1">
        <property type="nucleotide sequence ID" value="XM_018179976.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CSI2"/>
    <dbReference type="GeneID" id="28763462"/>
    <dbReference type="InParanoid" id="A0A177CSI2"/>
    <dbReference type="OrthoDB" id="3767377at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="90"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="638"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="674"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="102"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="143"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG09892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="727" mass="81464" checksum="72E58E2A14C844A7" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CSS7</accession>
    <name>A0A177CSS7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CC84DRAFT_1213895</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040950.1">
        <property type="nucleotide sequence ID" value="XM_018182583.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CSS7"/>
    <dbReference type="GeneID" id="28766069"/>
    <dbReference type="InParanoid" id="A0A177CSS7"/>
    <dbReference type="OrthoDB" id="3793892at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050731">
        <property type="entry name" value="HRD1_E3_ubiq-ligases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22763">
        <property type="entry name" value="RING ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="5">
        <location>
            <begin position="66"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAG10585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="200" mass="22167" checksum="66F7F62E7526E3D9" modified="2016-09-07" version="1">MEETQHREKGIRFEAESLGDPITVLDAAEAEADSARCTASFRTLVHFIKFNVRYLPIDAGSLDGGCPICREKTSKSQEGMLQVDLPACKHIFGADCFERYIQRSYTCPMCREIWFEKRLTPETPSTQGRSGQVVIEVSITSDEAADSLLNALQNESGEMVRRLLGEQIAELDENEGMLSSSLQLLGMNLIPAVNLASFSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CT86</accession>
    <name>A0A177CT86_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HAD-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1138506</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040563.1">
        <property type="nucleotide sequence ID" value="XM_018176198.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CT86"/>
    <dbReference type="STRING" id="1460663.A0A177CT86"/>
    <dbReference type="GeneID" id="28759684"/>
    <dbReference type="InParanoid" id="A0A177CT86"/>
    <dbReference type="OrthoDB" id="2107174at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07505">
        <property type="entry name" value="HAD_BPGM-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="entry name" value="Putative phosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044999">
        <property type="entry name" value="CbbY-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42896:SF2">
        <property type="entry name" value="CBBY-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42896">
        <property type="entry name" value="XYLULOSE-1,5-BISPHOSPHATE (XUBP) PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00413">
        <property type="entry name" value="HADHALOGNASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG10198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="249" mass="27856" checksum="D832EBED18F30983" modified="2016-09-07" version="1">MGKAKYILLDCDNTLCQSEHLAFEACADLTNKVLEKHGITDKRYTAESLLEDFVGYNFRRMLLALQPKHNFKMSDEELEEFVEAELGAVTKKLSEKAVECPGVTEQLEWLKKEGYPMSVVSTSAKSRVVASLKKTNLERFFTDEHVYSAATSLNPPSSKPDPAIYHYACKELGVKESEAITVEDSKSGATAAMRAGIPCIGYVGIYGIEEGKEKMEQMAKLLTEETKCVAIMYDWKEFPEALKKVEAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CTG0</accession>
    <name>A0A177CTG0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1161078</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040432.1">
        <property type="nucleotide sequence ID" value="XM_018177647.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CTG0"/>
    <dbReference type="GeneID" id="28761133"/>
    <dbReference type="InParanoid" id="A0A177CTG0"/>
    <dbReference type="OrthoDB" id="3886346at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="259"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="309"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG10067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="330" mass="36469" checksum="79A2DDDB38AF12A6" modified="2016-09-07" version="1">MGDTEKSFTFLHDNIPHWLDDVAGIEEKIVAMQSELSKIPVSRSLPFKKRSGSVESIRDLNAIREEPDASATGAHKSEPAARKRKEPSLLSGQQSGPSKLRSRTMIVVNYDGHIQTSFEQLVRAIGTGRNMLRKGKMAAKMDAMAAMAGSSSDDDDDDESNAVMAKIGYRHRGLSSMRARGMMRVTQNSSNTPVERFDTADKALEEAQALCERAAHQSLREGDCRKELGGVRRYFNEVVELAKTEVAQCTAQKLVADEKEQQQVLRPGPKPERQSSMPLPDVEKELMPTIIPPAISTNNTSKVIDIEIDDEEDSDDGSFVMPPVRLTSRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CTM1</accession>
    <name>A0A177CTM1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">[histone H3]-trimethyl-L-lysine(9) demethylase</fullName>
            <ecNumber evidence="2">1.14.11.66</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CC84DRAFT_1161712</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>N(6),N(6),N(6)-trimethyl-L-lysyl(9)-[histone H3] + 2 2-oxoglutarate + 2 O2 = N(6)-methyl-L-lysyl(9)-[histone H3] + 2 formaldehyde + 2 succinate + 2 CO2</text>
            <dbReference type="Rhea" id="RHEA:60200"/>
            <dbReference type="Rhea" id="RHEA-COMP:15538"/>
            <dbReference type="Rhea" id="RHEA-COMP:15542"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:16842"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:61929"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="EC" id="1.14.11.66"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the JHDM3 histone demethylase family.</text>
    </comment>
    <dbReference type="EC" id="1.14.11.66" evidence="2"/>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041249.1">
        <property type="nucleotide sequence ID" value="XM_018177815.1"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CTM1"/>
    <dbReference type="GeneID" id="28761301"/>
    <dbReference type="InParanoid" id="A0A177CTM1"/>
    <dbReference type="OrthoDB" id="9547406at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051864">
        <property type="term" value="F:histone H3K36 demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140684">
        <property type="term" value="F:histone H3K9me2/H3K9me3 demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15571">
        <property type="entry name" value="ePHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.650:FF:000024">
        <property type="entry name" value="Putative jumonji family transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000377">
        <property type="entry name" value="Putative jumonji family transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055500">
        <property type="entry name" value="DUF7072"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034732">
        <property type="entry name" value="EPHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003349">
        <property type="entry name" value="JmjN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10694:SF7">
        <property type="entry name" value="[HISTONE H3]-TRIMETHYL-L-LYSINE(9) DEMETHYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10694">
        <property type="entry name" value="LYSINE-SPECIFIC DEMETHYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23258">
        <property type="entry name" value="DUF7072"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02373">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02375">
        <property type="entry name" value="JmjN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13832">
        <property type="entry name" value="zf-HC5HC2H_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00545">
        <property type="entry name" value="JmjN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51805">
        <property type="entry name" value="EPHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51183">
        <property type="entry name" value="JMJN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="JmjN" evidence="8">
        <location>
            <begin position="79"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="JmjC" evidence="9">
        <location>
            <begin position="355"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="10">
        <location>
            <begin position="610"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="169"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="536"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="818"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="986"/>
            <end position="1176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1220"/>
            <end position="1346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="24"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="45"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="58"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="192"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="214"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="247"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="271"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="542"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="568"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="988"/>
            <end position="1005"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1016"/>
            <end position="1030"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1234"/>
            <end position="1252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="1253"/>
            <end position="1272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OAG10884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="1346" mass="150175" checksum="E8DDE7D7227D1DAC" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CTX5</accession>
    <name>A0A177CTX5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_482603</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040737.1">
        <property type="nucleotide sequence ID" value="XM_018186450.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CTX5"/>
    <dbReference type="STRING" id="1460663.A0A177CTX5"/>
    <dbReference type="GeneID" id="28769936"/>
    <dbReference type="InParanoid" id="A0A177CTX5"/>
    <dbReference type="OrthoDB" id="3800277at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="292"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="413"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="363"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="292"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG10372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="439" mass="49633" checksum="92168163F7ACC7EA" modified="2016-09-07" version="1">MANFGRMSKHCFSLGSLYKFPTRLFEFRFLGCRRSASTLREGTTGSTTPSVVEPPGHGVNLGSLYKSYEPVAGWGCFEDGSVYVNVKPWGSDMDHASFEAKMRLLEPLVRKPPPRIYQIRSEHPNLSRLIFVDCQPSIKLSKSEESCTIFVRNANDGEKLSEERHPFRRCHLTYDQLNFTQSSSKVDRPPIVLPHPVRMSMNRALENFRGTLVGGVLKPNVRLGNGLTLRKNHSLDKQRVLRGIQYFLKMENAREAQTKTPTPSSNTRHSVGFNALAGIVQGNLGSSLPEKALSRSRVDGKHSESESQSLTKRENKVSKRETAVNTREVAVSRREVAVNAREAMLNKREAAVYSKEASLYHREASLLQKVAALNKKEAKLNERRDTLDKRTVEFGIERRRHLAKNQKPEVDYDDIFPELANSDSSERRTRITLPQGPVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CU67</accession>
    <name>A0A177CU67_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphoribosylaminoimidazole-succinocarboxamide synthase</fullName>
            <ecNumber evidence="3">6.3.2.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">SAICAR synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CC84DRAFT_1193882</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SAICAR synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.6" evidence="3"/>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040795.1">
        <property type="nucleotide sequence ID" value="XM_018181331.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CU67"/>
    <dbReference type="FunCoup" id="A0A177CU67">
        <property type="interactions" value="756"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CU67"/>
    <dbReference type="GeneID" id="28764817"/>
    <dbReference type="InParanoid" id="A0A177CU67"/>
    <dbReference type="OrthoDB" id="9991235at2759"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00131"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004639">
        <property type="term" value="F:phosphoribosylaminoimidazolesuccinocarboxamide synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046084">
        <property type="term" value="P:adenine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01414">
        <property type="entry name" value="SAICAR_synt_Sc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000015">
        <property type="entry name" value="Phosphoribosylaminoimidazole-succinocarboxamide synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00137">
        <property type="entry name" value="SAICAR_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028923">
        <property type="entry name" value="SAICAR_synt/ADE2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001636">
        <property type="entry name" value="SAICAR_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018236">
        <property type="entry name" value="SAICAR_synthetase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010568">
        <property type="entry name" value="PRK13961.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00081">
        <property type="entry name" value="purC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43700">
        <property type="entry name" value="PHOSPHORIBOSYLAMINOIMIDAZOLE-SUCCINOCARBOXAMIDE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43700:SF1">
        <property type="entry name" value="PHOSPHORIBOSYLAMINOIMIDAZOLE-SUCCINOCARBOXAMIDE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01259">
        <property type="entry name" value="SAICAR_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56104">
        <property type="entry name" value="SAICAR synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01057">
        <property type="entry name" value="SAICAR_SYNTHETASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01058">
        <property type="entry name" value="SAICAR_SYNTHETASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAICAR synthetase/ADE2 N-terminal" evidence="10">
        <location>
            <begin position="18"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OAG10430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="308" mass="33934" checksum="4B4BC61E02610319" modified="2016-09-07" version="1">MASSTVVEVDIRGSLPKVASGKVRDLFAVDEQTLLFIASDRISAYDVVMENGIPGKGALLTQMSVYWFQYLKDHIPTLQTHFLSRSLPKALESLDRPLYEALESRSMQVKRLEIVPIESIVRGYITGSAWSEYKKSGTVHGIALPSGLVEGQKLPTPLWTPSTKAEAGEKDENISPQRAKVIIGDEKVAADVERLSLEIYLVAAARAEEAGIILADTKFEFGLDRANGNAVVLVDEVLTPDSSRFWPKDTWEAHLGKAQPSFDKQFLRDWLTSNGLKGKEGVTVPTDIVEQTAQKYKEACELLTGKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CUX4</accession>
    <name>A0A177CUX4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Kinase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CC84DRAFT_1139940</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG11011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041376.1">
        <property type="nucleotide sequence ID" value="XM_018176267.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CUX4"/>
    <dbReference type="STRING" id="1460663.A0A177CUX4"/>
    <dbReference type="GeneID" id="28759753"/>
    <dbReference type="InParanoid" id="A0A177CUX4"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110031">
        <property type="term" value="P:negative regulation of G2/MI transition of meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050339">
        <property type="entry name" value="CC_SR_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE EIF2-ALPHA KINASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042:SF190">
        <property type="entry name" value="MITOSIS INHIBITOR PROTEIN KINASE MIK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="146"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAG11011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="448" mass="50068" checksum="2F857BD0F3F9DA3D" modified="2016-09-07" version="1">MRLLQELHLNSSPPLPANITAQQVLASRISNFFPQGQGSRGPYTDSEIIEISELVKHLNQHWSNCPRTYIILRIIGHLDMLDRLIDIGFSDYWFPVTERNLPSCLLPSVKSSFVRTQSLVLTKSMDLEKGGNGQHCHFEKGEPVPFDPRGILGSGGFGQVDKVLSQISFKEYARKRVLRGTAFTGPRKEYIKQFVAEIQILKRLKHHHIVEFVGSYTDPKYIGLIMSPVADMDLGAYLKQATISNHPELRTFFGCLATALEFLHEQKIRHKDIKPGNILVNRGSILFTDFGLSFDFTDVDGSTTTSMPNGISYRYCAPEVAQYEPRNTMSDVWSLGVVFMEIIMVLKGRTAQDIDEFLRQHGSKGAYIRTNLDALLELIAELGEIGNSSDNRALGWTQQMLSVEQKLRPTASSIVTSIIAAGQEGDKISFCGICCIPSEDDFSSSAEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CV79</accession>
    <name>A0A177CV79_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cellulase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CC84DRAFT_495773</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041167.1">
        <property type="nucleotide sequence ID" value="XM_018186523.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CV79"/>
    <dbReference type="STRING" id="1460663.A0A177CV79"/>
    <dbReference type="GeneID" id="28770009"/>
    <dbReference type="InParanoid" id="A0A177CV79"/>
    <dbReference type="OrthoDB" id="442731at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31263">
        <property type="entry name" value="CELLULASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_5G14560)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31263:SF0">
        <property type="entry name" value="CELLULASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_5G14560)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008058694" evidence="5">
        <location>
            <begin position="19"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 5" evidence="6">
        <location>
            <begin position="60"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAG10802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="414" mass="45925" checksum="B2C5CFA124A38D74" modified="2016-09-07" version="1">MLPNTLLNTLLLAASTAAQFAPLHTSSRWILDSNNKRFKLRCLNWAGHMEAHLPEGLQHQPVDTLAKWVADQGFNCVRLTFSIDMALDQGLRVSDSFSTLAARTGAPADAVTDLWSRVKTKNSWIETISVGEAFGHVVDALGSAGLRVILDNHVSKASWCCNLEDGNGWWDEAPGYVDSNSRFFNTTNWVAGLRAMAQFSANHPAVAGIGLRNEIREIPVIQGRDAWYDYIVKGAHAVHDTNPDLLIAMGGTLSSTDISFLRTRPLDRAPFGDKIVYEWHHYTFTPNWIASFKSCSIWKSVTVGGTSGFLLQQGKDYTGPLWLSEFGFSQAGGPPERHGIETQEDYDYLTCLVDYVKGNDGDWALWAIQGSYYVRDGTVDKDESWGVLKSDFSDWRNPGVRDVIADLFKVTQGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CVE0</accession>
    <name>A0A177CVE0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1214054</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041122.1">
        <property type="nucleotide sequence ID" value="XM_018182602.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CVE0"/>
    <dbReference type="GeneID" id="28766088"/>
    <dbReference type="InParanoid" id="A0A177CVE0"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008058628" evidence="1">
        <location>
            <begin position="23"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG10757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="135" mass="14743" checksum="7785FE8E74CA3336" modified="2016-09-07" version="1">MSHLRLLPLFADLMALFALIFASPLAADVEAVNGSEPAPDANGKLCGYSAIQEGGFVVELYTNPCTDADQAEHFQTIYNKYCTLCIMFTGRGCTGDTTFVGGVMQDSKYIAPSQSYYCPWEKTDIEAAKKKYGIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CVI4</accession>
    <name>A0A177CVI4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ricin B lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1238105</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041267.1">
        <property type="nucleotide sequence ID" value="XM_018183925.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CVI4"/>
    <dbReference type="GeneID" id="28767411"/>
    <dbReference type="InParanoid" id="A0A177CVI4"/>
    <dbReference type="OrthoDB" id="3770800at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008058634" description="Ricin B lectin domain-containing protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG10902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="212" mass="23231" checksum="F74B9223B7AD3F28" modified="2016-09-07" version="1">MKVSTLLELLAPAAMFSTVQAGCYSADAPWWGSFQDAANAAVDQHCNPGGVSGYFAQGQTKYFCIQHSALQKSEFWVQWKGKGGLTLKDNDCKLRLKNEINGCKWGGESTIADWYFRSDPNIVKLNGIQFSQQRSITTPARLYKLSDSTSSSILPTIAIGESHHPRHEPARSWLRVSPVSLQSPAPSDPNLYPAFAYAHLGSEPPDSHSSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CVN3</accession>
    <name>A0A177CVN3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_1079410</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG11281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041646.1">
        <property type="nucleotide sequence ID" value="XM_018173847.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CVN3"/>
    <dbReference type="STRING" id="1460663.A0A177CVN3"/>
    <dbReference type="GeneID" id="28757333"/>
    <dbReference type="InParanoid" id="A0A177CVN3"/>
    <dbReference type="OrthoDB" id="3266505at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF9">
        <property type="entry name" value="MISCELLANEOUS ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="3">
        <location>
            <begin position="237"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAG11281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="674" mass="74997" checksum="21FC512E998921D8" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CVT6</accession>
    <name>A0A177CVT6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative sterol desaturase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CC84DRAFT_1139894</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041345.1">
        <property type="nucleotide sequence ID" value="XM_018176265.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CVT6"/>
    <dbReference type="STRING" id="1460663.A0A177CVT6"/>
    <dbReference type="GeneID" id="28759751"/>
    <dbReference type="InParanoid" id="A0A177CVT6"/>
    <dbReference type="OrthoDB" id="6354873at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006694">
        <property type="entry name" value="Fatty_acid_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050307">
        <property type="entry name" value="Sterol_Desaturase_Related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11863">
        <property type="entry name" value="STEROL DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04116">
        <property type="entry name" value="FA_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="57"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="142"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid hydroxylase" evidence="6">
        <location>
            <begin position="148"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAG10980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="314" mass="36679" checksum="EDF3A523FB96982F" modified="2016-09-07" version="1">MDVALEFLDPLILDKAYAWALPSAPLGIDYSNGTSPHKFSAAQTTSQWPRDNIYRQIISILALTQIGAMSLYLIFSALSYYLVFDRRLEYHPRFLKNQVRQEIISSFSAVPFINLLTLPIFLAEVRGHSLLYSNANEYGWTWLAVSTVLYMAFNDFAIYWIHRLEHHPSVYKYIHKPHHKWIVPTPWAALAFHPLDGFIQSTPYHLFVFICPMQRHLYMVLFVAVQIWTIFIHDGDMISGHWTEKWLNSPAHHTLHHMYFTVNYGQYFTWADTYFGSHRAPQPELDPLHDALKVLRAKGLVDENDQLIKKKKTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2023-06-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CW72</accession>
    <name>A0A177CW72_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_37420</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG11461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041826.1">
        <property type="nucleotide sequence ID" value="XM_018185955.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CW72"/>
    <dbReference type="GeneID" id="28769441"/>
    <dbReference type="InParanoid" id="A0A177CW72"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG11461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="137" mass="15275" checksum="F0CA9505553D283B" modified="2016-09-07" version="1">MQQNLRATHSLAVEGRLCTTTLLLHAEASNSVCCWTLPPAPCRGTSIANASDLSQCLQRAGLASLRGRLKHRVRTIFLAACIEHLLVLLIDLNQKVVSYRITQKYGLGPPHHFKQNCKPGMVLERQFSAQTRHTYGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CWJ2</accession>
    <name>A0A177CWJ2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">FAD/NAD(P)-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CC84DRAFT_1078759</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG11596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041961.1">
        <property type="nucleotide sequence ID" value="XM_018173810.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CWJ2"/>
    <dbReference type="STRING" id="1460663.A0A177CWJ2"/>
    <dbReference type="GeneID" id="28757296"/>
    <dbReference type="InParanoid" id="A0A177CWJ2"/>
    <dbReference type="OrthoDB" id="413885at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030248">
        <property type="term" value="F:cellulose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09630">
        <property type="entry name" value="CDH_like_cytochrome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1210">
        <property type="entry name" value="Cellobiose dehydrogenase, cytochrome domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.410.10">
        <property type="entry name" value="Cholesterol Oxidase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000254">
        <property type="entry name" value="CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035971">
        <property type="entry name" value="CBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015920">
        <property type="entry name" value="Cellobiose_DH-like_cyt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005018">
        <property type="entry name" value="DOMON_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053208">
        <property type="entry name" value="GMC_Oxidoreductase_CD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47190">
        <property type="entry name" value="DEHYDROGENASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47190:SF4">
        <property type="entry name" value="DEHYDROGENASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00734">
        <property type="entry name" value="CBM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16010">
        <property type="entry name" value="CDH-cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00664">
        <property type="entry name" value="DoH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00236">
        <property type="entry name" value="fCBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49344">
        <property type="entry name" value="CBD9-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57180">
        <property type="entry name" value="Cellulose-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00562">
        <property type="entry name" value="CBM1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51164">
        <property type="entry name" value="CBM1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00623">
        <property type="entry name" value="GMC_OXRED_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008058680" evidence="5">
        <location>
            <begin position="19"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="domain" description="CBM1" evidence="6">
        <location>
            <begin position="867"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="209"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="835"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="835"/>
            <end position="859"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAG11596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="904" mass="93238" checksum="C0B5A5A1D040A39C" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CWK3</accession>
    <name>A0A177CWK3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1159305</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG11893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042258.1">
        <property type="nucleotide sequence ID" value="XM_018177192.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CWK3"/>
    <dbReference type="GeneID" id="28760678"/>
    <dbReference type="InParanoid" id="A0A177CWK3"/>
    <dbReference type="OrthoDB" id="10486083at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG11893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="76" mass="8039" checksum="CB6C344D070E3078" modified="2016-09-07" version="1">MDGSTFRSRQFPKLPRTRRLRAPLLCSGCARGAISHPPTCSPRSELCQAASAHHLQSGAGAWAGPSPESTNGTLHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CXE2</accession>
    <name>A0A177CXE2_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PCI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1159023</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG11497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041862.1">
        <property type="nucleotide sequence ID" value="XM_018177116.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CXE2"/>
    <dbReference type="STRING" id="1460663.A0A177CXE2"/>
    <dbReference type="GeneID" id="28760602"/>
    <dbReference type="InParanoid" id="A0A177CXE2"/>
    <dbReference type="OrthoDB" id="5404651at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045114">
        <property type="entry name" value="Csn12-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12732:SF8">
        <property type="entry name" value="NUCLEAR MRNA EXPORT PROTEIN THP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12732">
        <property type="entry name" value="UNCHARACTERIZED PROTEASOME COMPONENT REGION PCI-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00753">
        <property type="entry name" value="PAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG11497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="560" mass="62535" checksum="C2D064B8F3085791" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CXY6</accession>
    <name>A0A177CXY6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1226700</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042799.1">
        <property type="nucleotide sequence ID" value="XM_018183594.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CXY6"/>
    <dbReference type="GeneID" id="28767080"/>
    <dbReference type="InParanoid" id="A0A177CXY6"/>
    <dbReference type="OrthoDB" id="47059at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG12434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="59" mass="6483" checksum="F162CAE97966FD24" modified="2016-09-07" version="1">MLRDHLGHFTPLSPRIGTRAQAVLSPKIICHRNPPAEHNLECFSEDPLISGNLAAAIVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2023-06-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CY30</accession>
    <name>A0A177CY30_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_67936</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042491.1">
        <property type="nucleotide sequence ID" value="XM_018187088.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CY30"/>
    <dbReference type="GeneID" id="28770574"/>
    <dbReference type="InParanoid" id="A0A177CY30"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG12126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="166" mass="18645" checksum="4DB88FB2DEA078D3" modified="2016-09-07" version="1">MRKPRQLAMTLSEISALAKAITCCYDMSISRACTPFLGIKFSFHTCSRNGPGALQRTNHKTLRRSLDCSRNRNLLFRRLYCKRRAGHLSITRPLRQAPQCTSFKKTKDAVHCQPPAVSPAAQLCPHLKFLPMTRCEVTVNPFTTIVSAWAGLTQLQPSRASRTTLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CYK9</accession>
    <name>A0A177CYK9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_64396</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2"/>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG11992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042357.1">
        <property type="nucleotide sequence ID" value="XM_018186993.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CYK9"/>
    <dbReference type="STRING" id="1460663.A0A177CYK9"/>
    <dbReference type="GeneID" id="28770479"/>
    <dbReference type="InParanoid" id="A0A177CYK9"/>
    <dbReference type="OrthoDB" id="426001at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033550">
        <property type="term" value="F:MAP kinase tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017017">
        <property type="term" value="F:MAP kinase tyrosine/serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008330">
        <property type="term" value="F:protein tyrosine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043409">
        <property type="term" value="P:negative regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14521">
        <property type="entry name" value="DSP_fungal_SDP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10159">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10159:SF519">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE MPK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="6">
        <location>
            <begin position="415"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="7">
        <location>
            <begin position="497"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="44"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="102"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="348"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="413"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="587"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1011"/>
            <end position="1112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1158"/>
            <end position="1211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="111"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="143"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="157"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="196"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="226"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="257"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="274"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="348"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="419"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1019"/>
            <end position="1031"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1057"/>
            <end position="1078"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1085"/>
            <end position="1110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1162"/>
            <end position="1175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1176"/>
            <end position="1191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAG11992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="1221" mass="134324" checksum="7166A3A99477966F" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CZ41</accession>
    <name>A0A177CZ41_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Hexose transporter-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_1182760</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG11949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042314.1">
        <property type="nucleotide sequence ID" value="XM_018180643.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CZ41"/>
    <dbReference type="GeneID" id="28764129"/>
    <dbReference type="InParanoid" id="A0A177CZ41"/>
    <dbReference type="OrthoDB" id="6133115at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000117">
        <property type="entry name" value="MFS hexose transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF29">
        <property type="entry name" value="SUGAR TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G14500)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="73"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="165"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="350"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="382"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="449"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="35"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAG11949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="517" mass="58397" checksum="DEF6335CF3C329BF" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CZ46</accession>
    <name>A0A177CZ46_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Magnesium-dependent phosphatase-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1078683</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042475.1">
        <property type="nucleotide sequence ID" value="XM_018173808.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CZ46"/>
    <dbReference type="FunCoup" id="A0A177CZ46">
        <property type="interactions" value="187"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CZ46"/>
    <dbReference type="GeneID" id="28757294"/>
    <dbReference type="InParanoid" id="A0A177CZ46"/>
    <dbReference type="OrthoDB" id="2865258at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07501">
        <property type="entry name" value="HAD_MDP-1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000155">
        <property type="entry name" value="Putative magnesium dependent phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010033">
        <property type="entry name" value="HAD_SF_ppase_IIIC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035679">
        <property type="entry name" value="MDP-1_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010036">
        <property type="entry name" value="MDP_1_eu_arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01681">
        <property type="entry name" value="HAD-SF-IIIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01685">
        <property type="entry name" value="MDP-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17901:SF14">
        <property type="entry name" value="MAGNESIUM-DEPENDENT PHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17901">
        <property type="entry name" value="MAGNESIUM-DEPENDENT PHOSPHATASE 1 MDP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12689">
        <property type="entry name" value="Acid_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01131">
        <property type="entry name" value="C1.5.2:_MDP_Like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG12110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="209" mass="23337" checksum="864FE3D7019D298E" modified="2016-09-07" version="1">MPRRGANSSFGSDAITTTALPQKTQWPATFTDGLPLPKIVVFDLDYTLWPFWVDTHVTGPLKAQEGGLKVKDRYGEGYGFYADVGGILDALKQKGILIGAASRTHAPDLGREMLKLLKIPSSTSSSSSRAIDYFDHLQIYPGNKTTHFERIHRDSGIEFEDMLFFDDESRNKNVEVLGVVMQLILDGVTINEIDAGVRSWRKRHNKVPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CZ76</accession>
    <name>A0A177CZ76_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1226079</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042505.1">
        <property type="nucleotide sequence ID" value="XM_018183582.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CZ76"/>
    <dbReference type="GeneID" id="28767068"/>
    <dbReference type="InParanoid" id="A0A177CZ76"/>
    <dbReference type="OrthoDB" id="10535160at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="235"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG12140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="265" mass="28413" checksum="0687C62FD7B45C2B" modified="2016-09-07" version="1">MASDLPRTGATAGQWPKFSHVAREELAHSQERLVTSAIHTSQRLGMAGPPTRVWSEVTCHRRDVGARAAPLPRWRSSSVSRAGHGAVLGSAANARPAQPPASVSWQAGRACPRTRAEQSTSVTISAAPVGGFWQQSHSEDRGPGVVVSSPEAAKNTGRLSFFDASPLPLCIVSISRGPASNPGPALQQPALRPHRRTAGSTRCQTAVMLTTLLVATVLRHAAEDLPGPAMTSRPQPRRQVQRRRTQPTRTCQLMLSWAASWSRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CZA4</accession>
    <name>A0A177CZA4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1080632</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018043229.1">
        <property type="nucleotide sequence ID" value="XM_018173899.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CZA4"/>
    <dbReference type="GeneID" id="28757385"/>
    <dbReference type="InParanoid" id="A0A177CZA4"/>
    <dbReference type="OrthoDB" id="3210850at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38848">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 3 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38848:SF3">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 3 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="175"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG12864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="218" mass="24336" checksum="DBC3909927F6A7FA" modified="2016-09-07" version="1">MYIAVLSFIICSAVMLAGQGLYNYGLCFGATWICLILYTVAKFVIYVFLVERIHVVRAPFVRRSRDWLYLSCLVLMSVSFLAVAINAYLSPIITMEADVGRCHMGIPGKASIPFMSVDIVVDVALTGVFVYLLRPAVKMHGLNKMNHVFKVPKSQMLGVAKELHDTTVRKNIRTLLWKSLIGSLLIMIPTVANMIQFYVMHGRELALVCLALCTIDGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CZE5</accession>
    <name>A0A177CZE5_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GRAM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1079355</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042672.1">
        <property type="nucleotide sequence ID" value="XM_018173844.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CZE5"/>
    <dbReference type="STRING" id="1460663.A0A177CZE5"/>
    <dbReference type="GeneID" id="28757330"/>
    <dbReference type="InParanoid" id="A0A177CZE5"/>
    <dbReference type="OrthoDB" id="1259151at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031490">
        <property type="term" value="F:chromatin DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13214">
        <property type="entry name" value="PH-GRAM_WBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044852">
        <property type="entry name" value="WBP2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31606">
        <property type="entry name" value="WW DOMAIN BINDING PROTEIN 2, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31606:SF1">
        <property type="entry name" value="WW DOMAIN BINDING PROTEIN 2, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="225"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="265"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG12307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="274" mass="29185" checksum="BB9B9A841A07B3AD" modified="2016-09-07" version="1">MGSYKHKKKPSNRNNSWVMLAEGSGYTPLPGETTLYQSPPRTTLSLQSPSRNTPAEAYSLQCKSGVIYLTNRRIIYLPVSPTPTFTSFAVPILNVSDSRVTAPWFGANKWEAAITPVYNGGIPASHSALELVMEFKEGGAFDFATTFERLRERLRHAVDVAASVGSAGDGVEGDGRGGGALAGVNLSGVHLEDLPAYEERGASVRVPDNLPSPPLGRGSVGTQGTGSTANRSSPMGSPRQEGFQEPPSEPPPGYEEVQRGGVADELERRLRGSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CZK8</accession>
    <name>A0A177CZK8_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Methyltransferase type 11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1135693</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018043111.1">
        <property type="nucleotide sequence ID" value="XM_018176069.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CZK8"/>
    <dbReference type="GeneID" id="28759555"/>
    <dbReference type="InParanoid" id="A0A177CZK8"/>
    <dbReference type="OrthoDB" id="3902588at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="31"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG12746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="611" mass="68948" checksum="155E6F716906DB29" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CZL7</accession>
    <name>A0A177CZL7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">superoxide dismutase</fullName>
            <ecNumber evidence="4">1.15.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CC84DRAFT_158157</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 13">
            <text>2 superoxide + 2 H(+) = H2O2 + O2</text>
            <dbReference type="Rhea" id="RHEA:20696"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:18421"/>
            <dbReference type="EC" id="1.15.1.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell envelope</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Cu-Zn superoxide dismutase family.</text>
    </comment>
    <dbReference type="EC" id="1.15.1.1" evidence="4"/>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018043121.1">
        <property type="nucleotide sequence ID" value="XM_018185415.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CZL7"/>
    <dbReference type="STRING" id="1460663.A0A177CZL7"/>
    <dbReference type="GeneID" id="28768901"/>
    <dbReference type="InParanoid" id="A0A177CZL7"/>
    <dbReference type="OrthoDB" id="159229at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004784">
        <property type="term" value="F:superoxide dismutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.200:FF:000007">
        <property type="entry name" value="Cell surface Cu-only superoxide dismutase 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.200">
        <property type="entry name" value="Superoxide dismutase, copper/zinc binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053257">
        <property type="entry name" value="Cu-only_SOD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036423">
        <property type="entry name" value="SOD-like_Cu/Zn_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001424">
        <property type="entry name" value="SOD_Cu_Zn_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20910">
        <property type="entry name" value="AGAP001623-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20910:SF1">
        <property type="entry name" value="SUPEROXIDE DISMUTASE COPPER_ZINC BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00080">
        <property type="entry name" value="Sod_Cu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49329">
        <property type="entry name" value="Cu,Zn superoxide dismutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008058802" description="superoxide dismutase" evidence="9">
        <location>
            <begin position="19"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="Superoxide dismutase copper/zinc binding" evidence="10">
        <location>
            <begin position="45"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="196"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="196"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="207"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OAG12756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="260" mass="26129" checksum="29FE3111341243AE" modified="2016-09-07" version="1">MRTQSVFTLLAVAAAVVAEDAPVVEHNPIGAQYEATLKPKGKYEVSGAVKIASGAAGKGVTIEIALAGLPAQGGPFLYHIHEKPVPEDGNCTGTGAHLDPYKRGETPPCDASDKASCQTGDLSGKYGKIESTSFSATYNDEFLATLTDDVSYFGDKSIVVHLANKTRIACANFKQLSPGDVTTTASSVGTSYGTALPSGSASHGHNATTSATPTGSTGAPIQPTASPTASTTAAPPNTGAAGKVAVSGAALLAFAAAMML</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CZR3</accession>
    <name>A0A177CZR3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_128646</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042933.1">
        <property type="nucleotide sequence ID" value="XM_018185361.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CZR3"/>
    <dbReference type="STRING" id="1460663.A0A177CZR3"/>
    <dbReference type="GeneID" id="28768847"/>
    <dbReference type="InParanoid" id="A0A177CZR3"/>
    <dbReference type="OrthoDB" id="1001765at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00657">
        <property type="entry name" value="Ferritin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052965">
        <property type="entry name" value="Pigment-catalase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31694">
        <property type="entry name" value="DESICCATION-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31694:SF8">
        <property type="entry name" value="STRESS RESPONSE PROTEIN RDS1P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13668">
        <property type="entry name" value="Ferritin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="Ferritin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008058807" evidence="1">
        <location>
            <begin position="21"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG12568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="323" mass="32260" checksum="8F45E2198843D571" modified="2016-09-07" version="1">MPSVRSIIGGLMALAPLAAAAPAGIIARQAASSSTTSSAAAATSSAAAAAPPAAAPAAGGGLTDVDILQFALTAEHLESTFYSQGFAKFPMSDFTALGLTDAQIKSLKGVGQTEATHVTTLQAAIAGAGAKPVEPCQYNFDAALKDAKTMVATARVLEAVGVSAYLGAAPLVNSSDVLTAAATIVTVEARHQAFIRSASGAEPVPAAFDTPLGPRAVFTLAAQFISSCPQGSNLNIQAFPSIALQNPEQAAVGSNLKLADAANPAGAQFCAFVAPGGNQFSQITNGNCVVPQNLSGEVYMMITKSQSVADAEVLAGPSVIQPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CZS6</accession>
    <name>A0A177CZS6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DHS-like NAD/FAD-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CC84DRAFT_1171136</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sirtuin family. Class I subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042767.1">
        <property type="nucleotide sequence ID" value="XM_018179895.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CZS6"/>
    <dbReference type="STRING" id="1460663.A0A177CZS6"/>
    <dbReference type="GeneID" id="28763381"/>
    <dbReference type="InParanoid" id="A0A177CZS6"/>
    <dbReference type="OrthoDB" id="424302at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017136">
        <property type="term" value="F:histone deacetylase activity, NAD-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036054">
        <property type="term" value="F:protein-malonyllysine demalonylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036055">
        <property type="term" value="F:protein-succinyllysine desuccinylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01412">
        <property type="entry name" value="SIRT5_Af1_CobB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1600.10">
        <property type="entry name" value="SIR2/SIRT2 'Small Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050134">
        <property type="entry name" value="NAD-dep_sirtuin_deacylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026591">
        <property type="entry name" value="Sirtuin_cat_small_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027546">
        <property type="entry name" value="Sirtuin_class_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085:SF10">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="5">
        <location>
            <begin position="9"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="132"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAG12402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="327" mass="35506" checksum="1FCD78C59966967B" modified="2016-09-07" version="1">MASSASRPGVVPQQDLESFQEHLNKSTRILALLGAGLSASSGLPTFRGAGGLWRTHDATQLATPEAFSADPGLVWQFYSYRRHMALKAKPNPAHYALAELSRKKESFLTLSQNVDGLSPRANHPEESLKLLHGSLFDVKCSDFFCNYLEKNNYTDPIVPALAIPTSEEDPTTTSALASRELDIADENVPIPELSYKHLPKCPKCKRGLLRPGVVWFGEMLPEKVLDDIEEWIQKKDPIDLIMVIGTSAKVYPAAGFVDRARAKGARVAIINMDKNDVPASGLAKGDWFFQGDAAQILPEILSSLIGELKETPDAAAGADNAVIEAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CZV0</accession>
    <name>A0A177CZV0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Extragenic suppressor of kinetochore protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_1080074</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SAPS family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042817.1">
        <property type="nucleotide sequence ID" value="XM_018173875.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CZV0"/>
    <dbReference type="FunCoup" id="A0A177CZV0">
        <property type="interactions" value="983"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CZV0"/>
    <dbReference type="GeneID" id="28757361"/>
    <dbReference type="InParanoid" id="A0A177CZV0"/>
    <dbReference type="OrthoDB" id="295029at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019903">
        <property type="term" value="F:protein phosphatase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007587">
        <property type="entry name" value="SAPS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12634:SF8">
        <property type="entry name" value="FIERY MOUNTAIN, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12634">
        <property type="entry name" value="SIT4 YEAST -ASSOCIATING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04499">
        <property type="entry name" value="SAPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="412"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="891"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="412"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="493"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="614"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="639"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="906"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="918"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="951"/>
            <end position="960"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAG12452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="960" mass="106204" checksum="514B212794AD7857" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CZX9</accession>
    <name>A0A177CZX9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_155588</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018043056.1">
        <property type="nucleotide sequence ID" value="XM_018185395.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CZX9"/>
    <dbReference type="GeneID" id="28768881"/>
    <dbReference type="InParanoid" id="A0A177CZX9"/>
    <dbReference type="OrthoDB" id="10529390at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG12691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="171" mass="18921" checksum="750ECE19E88EFA68" modified="2016-09-07" version="1">MQQHFPNFRLALSNPTRLVHTYTRALQPALAPASILCVARLFCPLHASYPKLYALRPVVTTIPDTHSGVKPHLPPPCIYSSSASRYFLVSRSTTFPAFVSLCCCIAALLCSVCAIFLLVYSCVSCGVYRWDTESFSLLSVSNPHQHHASAWCRVMNLLKPQLVLCVNLIAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177D0B4</accession>
    <name>A0A177D0B4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">18S rRNA factor 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_1159948</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in the small subunit (SSU) processome assembly and function, and in the 18S rRNA synthesis. Required for the early cleavages at sites A0, A1 and A2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ESF2/ABP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018043042.1">
        <property type="nucleotide sequence ID" value="XM_018177368.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177D0B4"/>
    <dbReference type="FunCoup" id="A0A177D0B4">
        <property type="interactions" value="912"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177D0B4"/>
    <dbReference type="GeneID" id="28760854"/>
    <dbReference type="InParanoid" id="A0A177D0B4"/>
    <dbReference type="OrthoDB" id="287393at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000480">
        <property type="term" value="P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000472">
        <property type="term" value="P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034462">
        <property type="term" value="P:small-subunit processome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12263">
        <property type="entry name" value="RRM_ABT1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039119">
        <property type="entry name" value="ABT1/Esf2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034353">
        <property type="entry name" value="ABT1/ESF2_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12311">
        <property type="entry name" value="ACTIVATOR OF BASAL TRANSCRIPTION 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12311:SF7">
        <property type="entry name" value="ACTIVATOR OF BASAL TRANSCRIPTION 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="264"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="10"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="31"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="44"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="264"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="295"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="305"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAG12677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="331" mass="37843" checksum="F6BAC64D3F8CA853" modified="2016-09-07" version="1">MATRKRNEWLDADESDEEERDYESEDESRSRMLKSTKRRKIEYESDSEDAADEPDADDRDDPKDEDDAHDEPTFDSPAAELAHLEKLAATLPKDLKLPSTQLGTPLPLPSKPKKDKSGVIYLSRIPPFMKPTVLRSLLTPYGAVGRVFMTPEPAASRTQRLRTGGTRRKLFLDGWVEFLSKKDAKFVAENLNAQTMGGKKRGRWHDEVWNVKYLSGVKWAHLVEQIQNENAERTARLRVEIAKGKKENERFLENVERGKMLGGMEAKRKAKGEEEPVFEREEADAVGETEGQQSGRKKERRSKFSQREMRTKADKKPEPGQDVQRVLGSIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177D0W9</accession>
    <name>A0A177D0W9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1255244</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG13136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018043501.1">
        <property type="nucleotide sequence ID" value="XM_018184522.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177D0W9"/>
    <dbReference type="GeneID" id="28768008"/>
    <dbReference type="InParanoid" id="A0A177D0W9"/>
    <dbReference type="OrthoDB" id="3800240at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="123"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="329"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="401"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="513"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="61"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="96"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG13136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="791" mass="91252" checksum="E93D8F9AFF8A8F8D" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BTN2</accession>
    <name>A0A177BTN2_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CC84DRAFT_1264765</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441564">
        <property type="protein sequence ID" value="OAF98772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029138.1">
        <property type="nucleotide sequence ID" value="XM_018185332.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BTN2"/>
    <dbReference type="STRING" id="1460663.A0A177BTN2"/>
    <dbReference type="GeneID" id="28768818"/>
    <dbReference type="InParanoid" id="A0A177BTN2"/>
    <dbReference type="OrthoDB" id="444631at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF158">
        <property type="entry name" value="MEMBRANE PROTEIN PTH11-LIKE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="75"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="122"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="152"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="202"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="234"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="273"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="63"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="308"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="308"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAF98772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="398" mass="44268" checksum="5A0D088824840BCE" modified="2016-09-07" version="1">MSDTGTNGDFDPSKLDPALLATFPALTPPSGVEPNFNNPRSIAYQCQVAVYVLLPIMLVHVVLRIYTRLQVKNSLGIDDYSCAVSSLMMTAYCSIILRSPHQWDVRLIDLTESFVKMSTTQFIMYSFTATFIKLSILLLYRRLFWIRDSARYMICIGMVVTALFYLACFISSLIHCVPRHGEGWLSQESKQRCAQPELEVSVVQGVFGVISDFYLLLIPMLQVTRLRVTTSQKIGLAGLFLTGLLACICSVTLCIYRFRQRGTDDFTYMSVPVYTFAVAELNVGIICSCMPVIFVVVKSFSKKVTSTIRGRSSGSRSGELPTDGVPPNCSSEAKPLKPLPGVPRGHLSTLMSFIRSGRRNNTEAGSLVNGDLILTNMSDFDPRKDTYHAHIQSIEDRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BUA9</accession>
    <name>A0A177BUA9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MMS19 nucleotide excision repair protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_1264588</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into apoproteins specifically involved in DNA metabolism and genomic integrity. In the CIA complex, MMS19 acts as an adapter between early-acting CIA components and a subset of cellular target iron-sulfur proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the MET18/MMS19 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441563">
        <property type="protein sequence ID" value="OAF99033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029399.1">
        <property type="nucleotide sequence ID" value="XM_018185318.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BUA9"/>
    <dbReference type="FunCoup" id="A0A177BUA9">
        <property type="interactions" value="946"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177BUA9"/>
    <dbReference type="GeneID" id="28768804"/>
    <dbReference type="InParanoid" id="A0A177BUA9"/>
    <dbReference type="OrthoDB" id="342900at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097361">
        <property type="term" value="C:cytosolic [4Fe-4S] assembly targeting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051604">
        <property type="term" value="P:protein maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039920">
        <property type="entry name" value="MMS19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024687">
        <property type="entry name" value="MMS19_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029240">
        <property type="entry name" value="MMS19_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12891">
        <property type="entry name" value="DNA REPAIR/TRANSCRIPTION PROTEIN MET18/MMS19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12891:SF0">
        <property type="entry name" value="MMS19 NUCLEOTIDE EXCISION REPAIR PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12460">
        <property type="entry name" value="MMS19_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14500">
        <property type="entry name" value="MMS19_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="MMS19 N-terminal" evidence="7">
        <location>
            <begin position="40"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="MMS19 C-terminal" evidence="6">
        <location>
            <begin position="549"/>
            <end position="970"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU367072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAF99033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="1021" mass="113307" checksum="8795646D00C92C44" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BVX9</accession>
    <name>A0A177BVX9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">p-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1169181</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441561">
        <property type="protein sequence ID" value="OAF99653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030019.1">
        <property type="nucleotide sequence ID" value="XM_018179589.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BVX9"/>
    <dbReference type="STRING" id="1460663.A0A177BVX9"/>
    <dbReference type="GeneID" id="28763075"/>
    <dbReference type="InParanoid" id="A0A177BVX9"/>
    <dbReference type="OrthoDB" id="10042665at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19481">
        <property type="entry name" value="RecA-like_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054289">
        <property type="entry name" value="DUF7025"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46411:SF3">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46411">
        <property type="entry name" value="FAMILY ATPASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22942">
        <property type="entry name" value="DUF7025"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="2">
        <location>
            <begin position="444"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAF99653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="650" mass="73595" checksum="42329D166BD3515C" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BW15</accession>
    <name>A0A177BW15_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Extracellular serine-rich protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1169205</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441561">
        <property type="protein sequence ID" value="OAF99683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030049.1">
        <property type="nucleotide sequence ID" value="XM_018179596.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BW15"/>
    <dbReference type="STRING" id="1460663.A0A177BW15"/>
    <dbReference type="GeneID" id="28763082"/>
    <dbReference type="InParanoid" id="A0A177BW15"/>
    <dbReference type="OrthoDB" id="5415867at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00920">
        <property type="entry name" value="Cupredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052953">
        <property type="entry name" value="Ser-rich/MCO-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34883:SF15">
        <property type="entry name" value="EXTRACELLULAR SERINE-RICH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34883">
        <property type="entry name" value="SERINE-RICH PROTEIN, PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008057379" description="Extracellular serine-rich protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAF99683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="179" mass="19063" checksum="E5713B3D735CEB14" modified="2016-09-07" version="1">MVAFTTLAFAATSLLGLTTAAPNSIPPTGVIHRITAGSTVENNGLHFEPQNVVAAIGDLIEFHFLPKNHTVVQSSFDAPCEPLADGTGIFSGFNFATPSGEAPNVFTFLVKNDKPLWYYCSQTNGDHCQKGMSGVINQNFDGDKTLAAYKEKAKTAVTKQPSEDKLAFQGGSIVKNVPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BWS7</accession>
    <name>A0A177BWS7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CC84DRAFT_426292</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441564">
        <property type="protein sequence ID" value="OAF98816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029182.1">
        <property type="nucleotide sequence ID" value="XM_018186182.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BWS7"/>
    <dbReference type="STRING" id="1460663.A0A177BWS7"/>
    <dbReference type="GeneID" id="28769668"/>
    <dbReference type="InParanoid" id="A0A177BWS7"/>
    <dbReference type="OrthoDB" id="10017208at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF47">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="51"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="90"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="127"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="170"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="205"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="32"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="299"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="321"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAF98816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="331" mass="37174" checksum="46488D8E1FD25A7F" modified="2016-09-07" version="1">MRPHSREELDNKWKIIQHAALLSALVVCIVTIRIASSLLQWKRLSVPEYLLLFATAGSLALNGASIFVVDSGGLGHHIGNVSRAQLVYLFKFYFAAALLIPTCFATAKLSLLWLLHRIFAHSWFRNVVRVLAGVVVAWWVASIVQEVRICYPVETRWKGTCKGKHSLRTYLILPIPWIVTDWLILLTPLPVLWKNIDTRRSRATQVGLLTLFGLGIVTCCISIKRFIVQLKTNVDDLTFTLAEPTLWQMIDLSTTICCAALPGSTHTLKRMLPVDLLEQAVDWVERKWHATKQSSCTSRSVTAEDAEANLPPVSTLRHTQDPMSDPTSNQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BWU5</accession>
    <name>A0A177BWU5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_1105757</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV441564">
        <property type="protein sequence ID" value="OAF98836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029202.1">
        <property type="nucleotide sequence ID" value="XM_018175111.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BWU5"/>
    <dbReference type="STRING" id="1460663.A0A177BWU5"/>
    <dbReference type="GeneID" id="28758597"/>
    <dbReference type="InParanoid" id="A0A177BWU5"/>
    <dbReference type="OrthoDB" id="5296287at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF68">
        <property type="entry name" value="MULTIDRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01120)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="49"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="115"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="140"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="173"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="201"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="273"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="318"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="359"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="384"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="424"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="456"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="48"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAF98836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="488" mass="53405" checksum="868AB693152A44C2" modified="2016-09-07" version="1">MVEKEVENDQAVAIEEDGRTVQGDVVDWAGEDDVEKPLNWTNKRKAKQIVVICYNTFLTPLGSTMFAPAIQQVMTTFQSSNPLLASFVVSVWVLGYFFGPLVIGPLSELYGRLPIYAICSVLFVLANVATALAPSLGSLIFFRFLAGTFGASPITIGAGTFGDLIKPQHRGGIIAIWSLGPLLGPILGPIAGGYLGEDAGWRWICWVLAIAAGVGSVATIVFQEETYPVVLLERKAARLRKETGNENLTSALAGAKMKPREVFARGIIRPMRLLIFSPIVASLSIYQGLVYGFMYLLFTTFPIVFQYQYGFSTGTIGLTYLGMGVGSLIGLTWGGVWSDALYKKKSKEGAGRWKPEYRLLPLVPGCLFIPIGLFWYGWSAQAKVHWIVPIVGTMFMGVGVNMVMMCIVTYIIDSYPLYEASASGALTAVRSLIGALVPLFGRSMYQALNLGWGNSLLGFLALAMCPLPWLFLMYGERIRTNPRFQVKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BXF0</accession>
    <name>A0A177BXF0_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HTH TFE/IIEalpha-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CC84DRAFT_1200050</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441562">
        <property type="protein sequence ID" value="OAF99381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029747.1">
        <property type="nucleotide sequence ID" value="XM_018181650.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BXF0"/>
    <dbReference type="FunCoup" id="A0A177BXF0">
        <property type="interactions" value="128"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177BXF0"/>
    <dbReference type="GeneID" id="28765136"/>
    <dbReference type="InParanoid" id="A0A177BXF0"/>
    <dbReference type="OrthoDB" id="361102at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005673">
        <property type="term" value="C:transcription factor TFIIE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039997">
        <property type="entry name" value="TFE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017919">
        <property type="entry name" value="TFIIE/TFIIEa_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002853">
        <property type="entry name" value="TFIIE_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024550">
        <property type="entry name" value="TFIIEa/SarR/Rpc3_HTH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13097:SF7">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13097">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIE, ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02002">
        <property type="entry name" value="TFIIE_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00531">
        <property type="entry name" value="TFIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51344">
        <property type="entry name" value="HTH_TFE_IIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH TFE/IIEalpha-type" evidence="4">
        <location>
            <begin position="7"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="278"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="338"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="291"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="344"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="377"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="396"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAF99381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="409" mass="45079" checksum="A0883F9310E910EE" modified="2016-09-07" version="1">MDPLELGKLFVKTAVRMFYDTEHIVIVDALIFHGALNTPDLVIVLDMGKSTKQVNKYIGKLNQAGLISIFSRQETREGALKAVTRDYYYIDYRRAIDSVKLKIHKIDARIKKDAKPTTEKFEYVCRNIGCESQYTQIEVLDSIDPMGRESGFLCKKCLRPLIYLGDDEGPDLDSDDTPAKFNKQFKPILDLMQRVDGVTIPHIEGKDAVEGAVELPRDKEINPGAKHEVVQENSVRPAAVKGTNTVVEKIDVTIKSSSDYNEDAHAQEKARQERIAAQNQLPSWHVKSTVDKSQASSAATPITATNGTGTPSIKAEMVNIKPDPAGNLDDVFAQLAAERAKQEAEDDDDEEDDDDDDEFEDAMVDTAPDSKRVKLESSAAPTPTSAATPAISTGDGGDESDEDEFEDVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BXM5</accession>
    <name>A0A177BXM5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Bola-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1131073</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the BolA/IbaG family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441562">
        <property type="protein sequence ID" value="OAF99267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029633.1">
        <property type="nucleotide sequence ID" value="XM_018175883.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BXM5"/>
    <dbReference type="FunCoup" id="A0A177BXM5">
        <property type="interactions" value="79"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177BXM5"/>
    <dbReference type="GeneID" id="28759369"/>
    <dbReference type="InParanoid" id="A0A177BXM5"/>
    <dbReference type="OrthoDB" id="203381at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.90">
        <property type="entry name" value="BolA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002634">
        <property type="entry name" value="BolA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036065">
        <property type="entry name" value="BolA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052275">
        <property type="entry name" value="Mt_Fe-S_assembly_factor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46188">
        <property type="entry name" value="BOLA-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46188:SF1">
        <property type="entry name" value="BOLA-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01722">
        <property type="entry name" value="BolA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82657">
        <property type="entry name" value="BolA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAF99267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="143" mass="15788" checksum="62697F985A96276A" modified="2016-09-07" version="1" fragment="single">MAPSRALLVVAHLRPSPRLLPAARRTLSNCAEAHRSRLSPALRSGPTRAFPALSRRGYATAAPEPPDYLNEAELHIFNKIKAELQPVKLEVQDISGGCGSMYALQIESEKFKGLSVIKQHKMVNEVLKEEIASWHGVQLRTKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BXN6</accession>
    <name>A0A177BXN6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1180329</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441559">
        <property type="protein sequence ID" value="OAG00284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030649.1">
        <property type="nucleotide sequence ID" value="XM_018180467.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BXN6"/>
    <dbReference type="STRING" id="1460663.A0A177BXN6"/>
    <dbReference type="GeneID" id="28763953"/>
    <dbReference type="InParanoid" id="A0A177BXN6"/>
    <dbReference type="OrthoDB" id="5396252at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42068">
        <property type="entry name" value="YALI0B18964P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42068:SF1">
        <property type="entry name" value="YALI0B18964P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="219"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="919"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="29"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="103"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="145"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="222"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="246"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="339"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="443"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="483"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="929"/>
            <end position="944"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG00284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="944" mass="101822" checksum="A2B0955FDA65A5A6" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BXT0</accession>
    <name>A0A177BXT0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">WD40 repeat-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_1181227</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441561">
        <property type="protein sequence ID" value="OAF99760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030126.1">
        <property type="nucleotide sequence ID" value="XM_018180538.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BXT0"/>
    <dbReference type="FunCoup" id="A0A177BXT0">
        <property type="interactions" value="758"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177BXT0"/>
    <dbReference type="GeneID" id="28764024"/>
    <dbReference type="InParanoid" id="A0A177BXT0"/>
    <dbReference type="OrthoDB" id="10266330at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08044">
        <property type="entry name" value="TAF5_NTD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.500">
        <property type="entry name" value="TFIID subunit TAF5, NTD2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007582">
        <property type="entry name" value="TFIID_NTD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037264">
        <property type="entry name" value="TFIID_NTD2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19879:SF1">
        <property type="entry name" value="CANNONBALL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19879">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04494">
        <property type="entry name" value="TFIID_NTD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160897">
        <property type="entry name" value="Taf5 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="TFIID subunit TAF5 NTD2" evidence="7">
        <location>
            <begin position="25"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="315"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="368"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="422"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="464"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="506"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="556"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="175"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="12"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="177"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAF99760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="666" mass="73443" checksum="D688F1A293742083" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2023-06-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BXT2</accession>
    <name>A0A177BXT2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1223419</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441563">
        <property type="protein sequence ID" value="OAF99139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029505.1">
        <property type="nucleotide sequence ID" value="XM_018183486.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BXT2"/>
    <dbReference type="GeneID" id="28766972"/>
    <dbReference type="InParanoid" id="A0A177BXT2"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAF99139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="154" mass="16406" checksum="44D3547481B66EFC" modified="2016-09-07" version="1">MNTPAAPASAPASPIFRYPVGTASPMYTTAVFDPVALNLSPDVVRAVSTPVPAIVVPLPVGRSSDTVKAKSLVGSVGAAAGAVSDAVELGTRVSVEGEKEVRLVREAEEVVDCADAVVLEDFVVRPRRENRVVLRREGRRIVVETKPELWFKDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BXV9</accession>
    <name>A0A177BXV9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Hexose transporter-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_1190887</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441560">
        <property type="protein sequence ID" value="OAG00155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030520.1">
        <property type="nucleotide sequence ID" value="XM_018181147.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BXV9"/>
    <dbReference type="GeneID" id="28764633"/>
    <dbReference type="InParanoid" id="A0A177BXV9"/>
    <dbReference type="OrthoDB" id="6133115at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000117">
        <property type="entry name" value="MFS hexose transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF29">
        <property type="entry name" value="SUGAR TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G14500)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="132"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="163"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="285"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="327"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="351"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="387"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="422"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="449"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="37"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAG00155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="563" mass="64170" checksum="E5E9C35BCCC1D29C" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BZ72</accession>
    <name>A0A177BZ72_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_1168909</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV441560">
        <property type="protein sequence ID" value="OAG00009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030374.1">
        <property type="nucleotide sequence ID" value="XM_018179521.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BZ72"/>
    <dbReference type="STRING" id="1460663.A0A177BZ72"/>
    <dbReference type="GeneID" id="28763007"/>
    <dbReference type="InParanoid" id="A0A177BZ72"/>
    <dbReference type="OrthoDB" id="2735536at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050425">
        <property type="entry name" value="NAD(P)_dehydrat-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366:SF579">
        <property type="entry name" value="3-BETA HYDROXYSTEROID DEHYDROGENASE_ISOMERASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_3G02250)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366">
        <property type="entry name" value="NAD DEPENDENT EPIMERASE/DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioester reductase (TE)" evidence="3">
        <location>
            <begin position="6"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAG00009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="227" mass="25233" checksum="9D9A1789DD3D9C43" modified="2016-09-07" version="1">MNIQDPSSFDTVMQGVTHVAHIASPFVLQVEDIERDLLKPAIEGTRGVLTAALKQPTIKSIVVTGSFATIADAKGGYRTGYTYTNKDFNPITYEEAKDPNLDMTQFPELHRHFARYMASKRCAEAAMWELYDKEKPSWTLNTINTAWVGGPYVLPLPSIAKASTSTGFLYGLATGADIPPQEWPTWIDVRDVAKAHINALQKPNLNKTRILIGGHRIGYDQVRQGDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BZK0</accession>
    <name>A0A177BZK0_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Carboxylesterase type B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_315938</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441559">
        <property type="protein sequence ID" value="OAG00586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030951.1">
        <property type="nucleotide sequence ID" value="XM_018185830.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BZK0"/>
    <dbReference type="STRING" id="1460663.A0A177BZK0"/>
    <dbReference type="GeneID" id="28769316"/>
    <dbReference type="InParanoid" id="A0A177BZK0"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="1">
        <location>
            <begin position="47"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG00586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="135" mass="14875" checksum="701915977333B2D4" modified="2016-09-07" version="1">MATYTSFSTLLTGVAHAQSYICPAHLVDLGYAKHVPIWTNVTATGTKLLNYNNIRYAHTPSGPLRFRKPETPPTYQNGIHSDNRNSWETDCISSAPQSVPFPLISGSTWGGEDCLFLNVIKPRNAKEGDELPVLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C073</accession>
    <name>A0A177C073_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glycoside hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CC84DRAFT_1190857</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 26 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441560">
        <property type="protein sequence ID" value="OAG00107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030472.1">
        <property type="nucleotide sequence ID" value="XM_018181144.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C073"/>
    <dbReference type="GeneID" id="28764630"/>
    <dbReference type="InParanoid" id="A0A177C073"/>
    <dbReference type="OrthoDB" id="428177at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016985">
        <property type="term" value="F:mannan endo-1,4-beta-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006080">
        <property type="term" value="P:substituted mannan metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022790">
        <property type="entry name" value="GH26_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000805">
        <property type="entry name" value="Glyco_hydro_26"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40079:SF6">
        <property type="entry name" value="GH26 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40079">
        <property type="entry name" value="MANNAN ENDO-1,4-BETA-MANNOSIDASE E-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02156">
        <property type="entry name" value="Glyco_hydro_26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51764">
        <property type="entry name" value="GH26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GH26" evidence="5">
        <location>
            <begin position="1"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="123"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAG00107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="324" mass="34950" checksum="A13751AE71B2FE9C" modified="2016-09-07" version="1">MSASLDLGLPNDALKTNCLSIGFLPSEGDSASRRYTMAEINSKLGAKASTYGWYAQITSSGFDGSQLLAVKDDVVASGAVFVASVMPSVNFNEITEDVAKQVASVMKQFTDAGVTVWLRYAHEMNWYVSDGTYHGSSADFLTSWKNIYNAACKDNAKVSCFWSPNQAGSASDLAPWWPGEDFVDLVGIDCYPRSGDDTSSNELFDRLYGSFYDAYSKPFGLPFAIGETGAGTGQKEQWLKTLVSQEKSKYPNYVSMSWFEFDKEADFQIVMTDDATLQSTKATLLSGGNEQCGGAGAGTALRVCRARGRGRARAGTANDGPTLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C0G1</accession>
    <name>A0A177C0G1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Molybdopterin binding oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CC84DRAFT_1156131</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mo-molybdopterin</name>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KV441560">
        <property type="protein sequence ID" value="OAG00100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030465.1">
        <property type="nucleotide sequence ID" value="XM_018176963.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C0G1"/>
    <dbReference type="STRING" id="1460663.A0A177C0G1"/>
    <dbReference type="GeneID" id="28760449"/>
    <dbReference type="InParanoid" id="A0A177C0G1"/>
    <dbReference type="OrthoDB" id="10051395at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030151">
        <property type="term" value="F:molybdenum ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043546">
        <property type="term" value="F:molybdopterin cofactor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008482">
        <property type="term" value="F:sulfite oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006790">
        <property type="term" value="P:sulfur compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02110">
        <property type="entry name" value="SO_family_Moco_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.420.10:FF:000002">
        <property type="entry name" value="sulfite oxidase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.650">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.420.10">
        <property type="entry name" value="Oxidoreductase, molybdopterin-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005066">
        <property type="entry name" value="MoCF_OxRdtse_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008335">
        <property type="entry name" value="Mopterin_OxRdtase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000572">
        <property type="entry name" value="OxRdtase_Mopterin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036374">
        <property type="entry name" value="OxRdtase_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19372:SF6">
        <property type="entry name" value="SULFITE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19372">
        <property type="entry name" value="SULFITE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03404">
        <property type="entry name" value="Mo-co_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00174">
        <property type="entry name" value="Oxidored_molyb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00407">
        <property type="entry name" value="EUMOPTERIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56524">
        <property type="entry name" value="Oxidoreductase molybdopterin-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidoreductase molybdopterin-binding" evidence="5">
        <location>
            <begin position="138"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="Moybdenum cofactor oxidoreductase dimerisation" evidence="6">
        <location>
            <begin position="345"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAG00100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="529" mass="61019" checksum="328963E0A16233B1" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C232</accession>
    <name>A0A177C232_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">SNF2 family helicase/ATPase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CC84DRAFT_1128212</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441558">
        <property type="protein sequence ID" value="OAG00949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031314.1">
        <property type="nucleotide sequence ID" value="XM_018175791.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C232"/>
    <dbReference type="STRING" id="1460663.A0A177C232"/>
    <dbReference type="GeneID" id="28759277"/>
    <dbReference type="InParanoid" id="A0A177C232"/>
    <dbReference type="OrthoDB" id="448448at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18008">
        <property type="entry name" value="DEXDc_SHPRH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050628">
        <property type="entry name" value="SNF2_RAD54_helicase_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626:SF16">
        <property type="entry name" value="ATP-DEPENDENT HELICASE ULS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="5">
        <location>
            <begin position="423"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="6">
        <location>
            <begin position="885"/>
            <end position="1059"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1041"/>
            <end position="1063"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="21"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="49"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="75"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAG00949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1063" mass="119689" checksum="3581DC97DB036930" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C2S3</accession>
    <name>A0A177C2S3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CENP-V/GFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CC84DRAFT_1167123</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfa family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441556">
        <property type="protein sequence ID" value="OAG01953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032318.1">
        <property type="nucleotide sequence ID" value="XM_018179119.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C2S3"/>
    <dbReference type="GeneID" id="28762605"/>
    <dbReference type="InParanoid" id="A0A177C2S3"/>
    <dbReference type="OrthoDB" id="5422068at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016846">
        <property type="term" value="F:carbon-sulfur lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1590.10">
        <property type="entry name" value="glutathione-dependent formaldehyde- activating enzyme (gfa)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006913">
        <property type="entry name" value="CENP-V/GFA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337:SF31">
        <property type="entry name" value="DUF636 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_2G12650)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337">
        <property type="entry name" value="GFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04828">
        <property type="entry name" value="GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51891">
        <property type="entry name" value="CENP_V_GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CENP-V/GFA" evidence="5">
        <location>
            <begin position="10"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAG01953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="387" mass="43010" checksum="8FCDFC2206144FA7" modified="2016-09-07" version="1">MAPSKDLVTLTANCLCKANTFTTQVPKSNLPLEGWACHCDSCRHATGAMYTQDSPWPEERANVDVSSLKAYNFSPKYDILFCPTCSTPLFFANTQDLNKKLGVFTGTLKNVSSDLVKTTEHIFVGDTGDGGASMWLRKPNADGTEAKRYKGRAEDENGQLAEAIPYDWPSHDKLTGYEAKTKDPVHIWCRCGGVNLLWEPPSYDGVKDEDLPWFVDPKTHKALAGFCACESCRLFGGVDVWNWAFAELKDIHFPNKVPGFPDSSDALRALVDAKDPSVGSLTYFASSSDAQRYFCSNCSACVFYAWDERNFMVDVALGVLEASDGARAEGTFSWAFGGAIGHLDENAGGWRFDQYQRVMKEGEEWRISRGYPKNWRRLAREKAEGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2023-06-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C363</accession>
    <name>A0A177C363_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_242119</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441557">
        <property type="protein sequence ID" value="OAG01836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032201.1">
        <property type="nucleotide sequence ID" value="XM_018185640.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C363"/>
    <dbReference type="GeneID" id="28769126"/>
    <dbReference type="InParanoid" id="A0A177C363"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG01836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="215" mass="24041" checksum="5E46F3C534FAEDCC" modified="2016-09-07" version="1">MQYAGGVSHHSWTLSTPTLGPGKTNINPIVECVRHRLRMIKSALGTECNRVPFLILERIRELYSALRLVTILLGTNCTRITLHQVTGSEYTHLVSSTGQTERLNGFSTVCETHKSQGYVARRTPQCRILTRLDCLQHPHTNASRSVPYAYGRALRRRNQPVYQARRCTDVALSVVRQLNVRSDSASVFPGGVQMPQIFSPDGPEMETSAEMAAYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C377</accession>
    <name>A0A177C377_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF8021 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1100597</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441557">
        <property type="protein sequence ID" value="OAG01342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031707.1">
        <property type="nucleotide sequence ID" value="XM_018174874.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C377"/>
    <dbReference type="STRING" id="1460663.A0A177C377"/>
    <dbReference type="GeneID" id="28758360"/>
    <dbReference type="InParanoid" id="A0A177C377"/>
    <dbReference type="OrthoDB" id="3504677at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058334">
        <property type="entry name" value="DUF8021"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26061">
        <property type="entry name" value="DUF8021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008057647" description="DUF8021 domain-containing protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="DUF8021" evidence="2">
        <location>
            <begin position="159"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG01342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="265" mass="28616" checksum="71000DAE4F84B141" modified="2016-09-07" version="1">MPSLSIVRSLMAIVALLETASAACTREGLLASAQSYIDAQKAGNTTALKLSPTFKYQQNNKERALSAGLLATPFKLDLVRSTADTVACASYTMWISSAGSKPYVVGTQIRHDGNDTSTITLIDTIAATTGDLFFNAPKTLGYIQKEDWSPINNTASMPSRELLKKVGNGYLDMWTDPKAADSIPWGTDCERVEGSQYTNPCGKNLPHGGSSKPNGMRRYVIDEVQGSVDVLCQFDSLGTMPDSHEIRVIDGKVKYVHTITALKIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C4X3</accession>
    <name>A0A177C4X3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CC84DRAFT_1098404</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441556">
        <property type="protein sequence ID" value="OAG01942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032307.1">
        <property type="nucleotide sequence ID" value="XM_018174765.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C4X3"/>
    <dbReference type="FunCoup" id="A0A177C4X3">
        <property type="interactions" value="16"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177C4X3"/>
    <dbReference type="GeneID" id="28758251"/>
    <dbReference type="InParanoid" id="A0A177C4X3"/>
    <dbReference type="OrthoDB" id="2153661at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046943">
        <property type="term" value="F:carboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000140">
        <property type="entry name" value="Putative MFS phospholipid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23508">
        <property type="entry name" value="CARBOXYLIC ACID TRANSPORTER PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23508:SF10">
        <property type="entry name" value="CARBOXYLIC ACID TRANSPORTER PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="136"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="173"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="225"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="263"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="295"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="391"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="1"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAG01942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="458" mass="49052" checksum="A4A5762DDA048F59" modified="2016-09-07" version="1">MLFSGLALGSDGYNAAVMSNLNLLLTVIYPDALSSDMKARLSNAFLIGMIVGMVGFGVVVDQLGRKTGAVLTTLILLLGIALSTGASGTSPLGLFWMLVVARGIAGVGAGGEYPVAGAGALEASDEAGHFRKRRGFLFAMIGDLAAGLGYCFGALVPLLLLLCVNQRVDKYHIVWRTALAVGAVPPLSIFYFRMRMKVSTAYRKSALRKQRTPYVLIAKKYYRRLFGAALGWFLYNWISIPFGIFGSTIVSRMNPENSLLQNLGWGVVINAFYLPGPFLGGYLSDKIGRRKTQCVGYTAQAILGFVLGGAGTQIQTVFPLFIVLYGIFLTLGEVGPGSTVVITATEPFPTSVRGHTMGFISACSKAGAAIGTEVFTAIMASYTDPNKSNQVAFLVGSAFAVLGALNAWFVIQDGSKVLDNEDEIWKDYLVANGWDANWGDHETEDPKLTRNQALLPTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C630</accession>
    <name>A0A177C630_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1220541</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441556">
        <property type="protein sequence ID" value="OAG02187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032552.1">
        <property type="nucleotide sequence ID" value="XM_018183180.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C630"/>
    <dbReference type="GeneID" id="28766666"/>
    <dbReference type="InParanoid" id="A0A177C630"/>
    <dbReference type="OrthoDB" id="3710622at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG02187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="262" mass="28998" checksum="7FA2ABCC9577CD1F" modified="2016-09-07" version="1">MSSPESKSRNSSFSKEQPAPPATLYQQDLSTWKTTTITVQSIDAGLLNGKRAWLVCLTLQFSCPHNDRFKKANIMLQFEPSEAGLASTAVVKRWAPQFLTGRRTTSSVEWAFEGSLTAGVDIPGSTINANTSLSRKESVVKEHSCSILSDTWKLPQLAEPNAVRFYIHENEQSRGGIPNRLNAVLVIQSDVACRGRATVETNGIKAMYVRGHHNPIELQVNVSYQPRFPEGVKDFSTLSTIEWQMLATPTLQMSDNIVGSDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C6C2</accession>
    <name>A0A177C6C2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1179178</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441556">
        <property type="protein sequence ID" value="OAG02240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032605.1">
        <property type="nucleotide sequence ID" value="XM_018180390.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C6C2"/>
    <dbReference type="GeneID" id="28763876"/>
    <dbReference type="InParanoid" id="A0A177C6C2"/>
    <dbReference type="OrthoDB" id="10638168at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG02240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="209" mass="23497" checksum="7090E27C9559B4B2" modified="2016-09-07" version="1">MSGETISKSYKKLSADEAALRDEKMMESLRSGVGYPNERPDASFQHHYPHESTAEQRTGGSPSKSSRTSVTGTVAPGSEYDNRLKEINLATASGGTITAYEWYNDPQALDMGYKQSHKENDLDWEKMDAHRRTMNGMAEEHRDGDADDEMESDPEEYLDRIESGKGTQGVRRAIYRLTASVLGECDIYQKDMILEHSMREIDGLGLSFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C6H9</accession>
    <name>A0A177C6H9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Dihydroxyacetone kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CC84DRAFT_1207954</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes both the phosphorylation of dihydroxyacetone and of glyceraldehyde.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>D-glyceraldehyde + ATP = D-glyceraldehyde 3-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13941"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.28"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>dihydroxyacetone + ATP = dihydroxyacetone phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15773"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16016"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.29"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Polyol metabolism; glycerol fermentation; glycerone phosphate from glycerol (oxidative route): step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the dihydroxyacetone kinase (DAK) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG03243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033608.1">
        <property type="nucleotide sequence ID" value="XM_018182129.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C6H9"/>
    <dbReference type="STRING" id="1460663.A0A177C6H9"/>
    <dbReference type="GeneID" id="28765615"/>
    <dbReference type="InParanoid" id="A0A177C6H9"/>
    <dbReference type="OrthoDB" id="1724672at2759"/>
    <dbReference type="UniPathway" id="UPA00617">
        <property type="reaction ID" value="UER00669"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004371">
        <property type="term" value="F:glycerone kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050354">
        <property type="term" value="F:triokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019588">
        <property type="term" value="P:anaerobic glycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10440:FF:000004">
        <property type="entry name" value="Dihydroxyacetone kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1180.20:FF:000001">
        <property type="entry name" value="Dihydroxyacetone kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.340:FF:000002">
        <property type="entry name" value="Dihydroxyacetone kinase, L subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10440">
        <property type="entry name" value="Dihydroxyacetone kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1180.20">
        <property type="entry name" value="Dihydroxyacetone kinase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012734">
        <property type="entry name" value="DhaK_ATP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004006">
        <property type="entry name" value="DhaK_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004007">
        <property type="entry name" value="DhaL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036117">
        <property type="entry name" value="DhaL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050861">
        <property type="entry name" value="Dihydroxyacetone_Kinase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02361">
        <property type="entry name" value="dak_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28629">
        <property type="entry name" value="TRIOKINASE/FMN CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28629:SF1">
        <property type="entry name" value="YALI0F01606P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02733">
        <property type="entry name" value="Dak1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02734">
        <property type="entry name" value="Dak2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01120">
        <property type="entry name" value="Dak2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82549">
        <property type="entry name" value="DAK1/DegV-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101473">
        <property type="entry name" value="DhaL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51481">
        <property type="entry name" value="DHAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51480">
        <property type="entry name" value="DHAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0319">Glycerol metabolism</keyword>
    <keyword evidence="6 16" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DhaK" evidence="15">
        <location>
            <begin position="9"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="DhaL" evidence="14">
        <location>
            <begin position="387"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="361"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="361"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-hemiaminal-histidine intermediate" evidence="11">
        <location>
            <position position="219"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="54"/>
            <end position="57"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR612734-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR612734-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OAG03243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="588" mass="61977" checksum="5CFC82C2FEEDE20A" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C6S2</accession>
    <name>A0A177C6S2_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CC84DRAFT_1055331</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG03454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033819.1">
        <property type="nucleotide sequence ID" value="XM_018173533.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C6S2"/>
    <dbReference type="STRING" id="1460663.A0A177C6S2"/>
    <dbReference type="GeneID" id="28757019"/>
    <dbReference type="InParanoid" id="A0A177C6S2"/>
    <dbReference type="OrthoDB" id="1875751at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12577">
        <property type="entry name" value="RRM1_Hrp1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000025">
        <property type="entry name" value="RNA-binding protein Musashi homolog 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034156">
        <property type="entry name" value="Hrp1_RRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48032:SF6">
        <property type="entry name" value="RNA-BINDING (RRM_RBD_RNP MOTIFS) FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48032">
        <property type="entry name" value="RNA-BINDING PROTEIN MUSASHI HOMOLOG RBP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="84"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAG03454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="161" mass="18160" checksum="F626093E1D262680" modified="2016-09-07" version="1" fragment="single">KMFIGGLNWETTEQSLKDYFTQFGEVSECTVMRDSATGRSRGFGFLTFKDPKCVNTVMVKEHYLDGKIIDPKRAIPREEQERTSKIFVGGVSQEATEEDFKNFFKQFGRVVDATLMMDKDTGRPRGFGFVTFDGDAAVDACLQGPLQILGKPIEVKRAQPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C6T4</accession>
    <name>A0A177C6T4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">D-lactate dehydratase</fullName>
            <ecNumber evidence="1">4.2.1.130</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CC84DRAFT_1189246</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>methylglyoxal + H2O = (R)-lactate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27754"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16004"/>
            <dbReference type="ChEBI" id="CHEBI:17158"/>
            <dbReference type="EC" id="4.2.1.130"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase C56 family. HSP31-like subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.130" evidence="1"/>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG03353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033718.1">
        <property type="nucleotide sequence ID" value="XM_018181039.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C6T4"/>
    <dbReference type="FunCoup" id="A0A177C6T4">
        <property type="interactions" value="60"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177C6T4"/>
    <dbReference type="GeneID" id="28764525"/>
    <dbReference type="InParanoid" id="A0A177C6T4"/>
    <dbReference type="OrthoDB" id="543156at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019172">
        <property type="term" value="F:glyoxalase III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019243">
        <property type="term" value="P:methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.880:FF:000051">
        <property type="entry name" value="Glutathione-independent glyoxalase HSP31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050325">
        <property type="entry name" value="Prot/Nucl_acid_deglycase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48094:SF11">
        <property type="entry name" value="GLUTATHIONE-INDEPENDENT GLYOXALASE HSP31-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48094">
        <property type="entry name" value="PROTEIN/NUCLEIC ACID DEGLYCASE DJ-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="DJ-1/PfpI" evidence="6">
        <location>
            <begin position="32"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAG03353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="239" mass="25931" checksum="AFC8EF492B6E9335" modified="2016-09-07" version="1">MSPPRRALIAVTSANASLFAPNGHTTGVFIGEALHPYNVLKAAGFEVDIASEKGKWTEDWLSLQPGFLSEEERKQYDDKKSDFRAEIDKNRKAEDLDASQYGVFFASAGHAALIDYPHATHLQAIASKVWANGGVVSAVCHGPAIFPGIVDTDGQPIIKGRKITGFTTQAEYDMKIMDALKSWGEPLVDEHARALGAEYVRADGVWDDFHVVDGRVVTGMNPQSAKSTTEAVVKVFNGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C7F5</accession>
    <name>A0A177C7F5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ras GEF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CC84DRAFT_1095726</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG03573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033938.1">
        <property type="nucleotide sequence ID" value="XM_018174627.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A177C7F5">
        <property type="interactions" value="165"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177C7F5"/>
    <dbReference type="GeneID" id="28758113"/>
    <dbReference type="InParanoid" id="A0A177C7F5"/>
    <dbReference type="OrthoDB" id="10254377at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06224">
        <property type="entry name" value="REM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.840.10">
        <property type="entry name" value="Ras guanine-nucleotide exchange factors catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.870.10">
        <property type="entry name" value="Son of sevenless (SoS) protein Chain: S domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008937">
        <property type="entry name" value="Ras-like_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000651">
        <property type="entry name" value="Ras-like_Gua-exchang_fac_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023578">
        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001895">
        <property type="entry name" value="RASGEF_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036964">
        <property type="entry name" value="RASGEF_cat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113:SF363">
        <property type="entry name" value="PROTEIN SON OF SEVENLESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00617">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00618">
        <property type="entry name" value="RasGEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00147">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00229">
        <property type="entry name" value="RasGEFN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48366">
        <property type="entry name" value="Ras GEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50009">
        <property type="entry name" value="RASGEF_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50212">
        <property type="entry name" value="RASGEF_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-terminal Ras-GEF" evidence="5">
        <location>
            <begin position="351"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GEF" evidence="4">
        <location>
            <begin position="1477"/>
            <end position="1721"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="107"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="518"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="626"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="766"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="971"/>
            <end position="1020"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1043"/>
            <end position="1090"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1104"/>
            <end position="1136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1174"/>
            <end position="1194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1207"/>
            <end position="1240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1361"/>
            <end position="1411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1446"/>
            <end position="1467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="58"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="133"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="535"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="566"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="639"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="766"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="788"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1069"/>
            <end position="1090"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1217"/>
            <end position="1228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1364"/>
            <end position="1375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAG03573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="1725" mass="191200" checksum="6C15F9EC63828338" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C7L4</accession>
    <name>A0A177C7L4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DUF1682-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CC84DRAFT_1097473</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG03121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033486.1">
        <property type="nucleotide sequence ID" value="XM_018174713.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C7L4"/>
    <dbReference type="FunCoup" id="A0A177C7L4">
        <property type="interactions" value="74"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177C7L4"/>
    <dbReference type="GeneID" id="28758199"/>
    <dbReference type="InParanoid" id="A0A177C7L4"/>
    <dbReference type="OrthoDB" id="10039147at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032469">
        <property type="term" value="P:endoplasmic reticulum calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012879">
        <property type="entry name" value="CCDC47"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12883">
        <property type="entry name" value="ADIPOCYTE-SPECIFIC PROTEIN 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12883:SF0">
        <property type="entry name" value="PAT COMPLEX SUBUNIT CCDC47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07946">
        <property type="entry name" value="CCDC47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="9"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="391"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="391"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="429"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAG03121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="439" mass="49487" checksum="72F96F6E23981904" modified="2016-09-07" version="1">MADFVKGLFGGQQQKVAQPHSGGDDDFADYAGAPDPSPVSFASSVGAASAVPTSTVGQVPYTAWYRVWERTSVDDFKLELYILPFILLIVVVHLWGTRRNRSKAHHWIKSHAPVLQQEFAQVGYTRPQAGANDVSAVGLVNPETFLREKKPDEFASYATGRANVAFVDFKLTLAKRFNPLMRFGELAISLFFESMPVPIERMEATAYVFDGQEAKIAPAIARGVGEKVANSTFDGFVFAVVHKDLMKRLREDRYDLSLTASKDHAKLPLWVTVMSESAEITDTMLTPELIKAITDAGDDFEALVITDQPMDQPKKLDDTVPRKRINLSLKLKSASTPYDSTLPLFQYFIRLPDFLASKAHFRPEALRRIKATREEQIAKIRKIDDEEKAEERKLASDKLKKEQRDAKLGRMTADEQRKYLDKERERDAKKRTKKQTVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C7T7</accession>
    <name>A0A177C7T7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">uracil phosphoribosyltransferase</fullName>
            <ecNumber evidence="4">2.4.2.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CC84DRAFT_1166632</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Pyrimidine metabolism; UMP biosynthesis via salvage pathway; UMP from uracil: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the UPRTase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.9" evidence="4"/>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG02817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033182.1">
        <property type="nucleotide sequence ID" value="XM_018179008.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C7T7"/>
    <dbReference type="STRING" id="1460663.A0A177C7T7"/>
    <dbReference type="GeneID" id="28762494"/>
    <dbReference type="InParanoid" id="A0A177C7T7"/>
    <dbReference type="OrthoDB" id="10257085at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004845">
        <property type="term" value="F:uracil phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000049">
        <property type="entry name" value="Putative uracil phosphoribosyltransferase urg2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050054">
        <property type="entry name" value="UPRTase/APRTase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001097">
        <property type="entry name" value="PRK00129.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32315">
        <property type="entry name" value="ADENINE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32315:SF4">
        <property type="entry name" value="URACIL PHOSPHORIBOSYLTRANSFERASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14681">
        <property type="entry name" value="UPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphoribosyltransferase" evidence="10">
        <location>
            <begin position="10"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF14681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OAG02817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="232" mass="24660" checksum="6F0E51BDD49651AB" modified="2016-09-07" version="1">MANLPKNAHVSQHPCLQAKLSQLRSASTSSKDVQSLVHDIALMVGYEALAQGLKAQQQGTDKSPLGYTYNTTTVSPHPTSISLVPILRSGLSMVPALTSLLPQPVAVHHLGLYREKSTLQPVEYYNNLPYHAPTTSNPNASGPSELAIIVDPVIATGATASAAIDSLKDWGVKRIIVVSVLATEEGLRQACGEWEEGVEVWVGGCDGEVDEKGMIKPGLGDIGDRLFLTIGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C8Z9</accession>
    <name>A0A177C8Z9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_870162</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG03856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034221.1">
        <property type="nucleotide sequence ID" value="XM_018187728.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C8Z9"/>
    <dbReference type="GeneID" id="28771214"/>
    <dbReference type="InParanoid" id="A0A177C8Z9"/>
    <dbReference type="OrthoDB" id="10646932at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG03856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="179" mass="20601" checksum="6772A0DE7E0B2F69" modified="2016-09-07" version="1">MRPQQPFQIETSRLQPSGTFRRIYRHSPLRATVEEQLHDLDLRQNSSLVPHQLRHAHKVPHSSSLGRNGLETTAFLHITIPFPRIVDSEDLTSSARVRFIMFVPQISVRCCFVDLLVGLYRCADRNKFARQQRFELRSNRTHAMHLILVSKGCFGVALGTGAVFSGPRFHLHWALVRRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C9B4</accession>
    <name>A0A177C9B4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNA helicase</fullName>
            <ecNumber evidence="3">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CC84DRAFT_1151861</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits and is required for the normal formation of 25S and 5.8S rRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the DEAD box helicase family. DDX56/DBP9 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="3"/>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG03347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033712.1">
        <property type="nucleotide sequence ID" value="XM_018176770.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C9B4"/>
    <dbReference type="FunCoup" id="A0A177C9B4">
        <property type="interactions" value="954"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177C9B4"/>
    <dbReference type="GeneID" id="28760256"/>
    <dbReference type="InParanoid" id="A0A177C9B4"/>
    <dbReference type="OrthoDB" id="1191041at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033677">
        <property type="term" value="F:DNA/RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd17961">
        <property type="entry name" value="DEADc_DDX56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF21">
        <property type="entry name" value="DEAD-BOX HELICASE 56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 18" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="9" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="17">
        <location>
            <begin position="40"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="15">
        <location>
            <begin position="71"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="16">
        <location>
            <begin position="254"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="347"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="13">
        <location>
            <begin position="40"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="349"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="OAG03347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="589" mass="65895" checksum="4A44B7A76C0EDAA3" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CAC8</accession>
    <name>A0A177CAC8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1207057</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG03779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034144.1">
        <property type="nucleotide sequence ID" value="XM_018182073.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CAC8"/>
    <dbReference type="STRING" id="1460663.A0A177CAC8"/>
    <dbReference type="GeneID" id="28765559"/>
    <dbReference type="InParanoid" id="A0A177CAC8"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23520">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G04000)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23520:SF5">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G04000)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="60"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG03779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="198" mass="21924" checksum="14C9E11F04F3E4FB" modified="2016-09-07" version="1">MRIACRVEVETPKKLTDANSSANTEGTPLLDDETGTARDEPRAKVRMWTLLPEISREDQAVMMSLWCLFGVDSFASGLIPLAWVIPCMVRRSRRTAGVTFLQDKYYCCGVHDRGFLARQTLQECSFFTHLPSAVTLALTPIPGPLVDDGVFWVALVAAGSLKECYDLGLLVVFQSYDREKAERERVAGDRSATSGDDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CB58</accession>
    <name>A0A177CB58_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Metallo-dependent phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1070043</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG04102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034467.1">
        <property type="nucleotide sequence ID" value="XM_018173662.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CB58"/>
    <dbReference type="GeneID" id="28757148"/>
    <dbReference type="InParanoid" id="A0A177CB58"/>
    <dbReference type="OrthoDB" id="630188at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07379">
        <property type="entry name" value="MPP_239FB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051693">
        <property type="entry name" value="UPF0046_metallophosphoest"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12905:SF18">
        <property type="entry name" value="ESTER HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G03130)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12905">
        <property type="entry name" value="METALLOPHOSPHOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="2">
        <location>
            <begin position="56"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG04102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="261" mass="29200" checksum="1E2177B4683DA42B" modified="2016-09-07" version="1" fragment="single">FRPAQPTPLQRFLRKPLLFIATYLYTHQPPLKQKRRNSNNSSSQSNGRTTPHHITVVCLSDTHNTQPLIPAADILLHAGDLTQNGTFAELQATLDWLAALPHRHKFVIAGNHDLLLSPSFVASAPSRVFTTTPGCTKEDLEWGDVTYLEDSSATVTVRGRDVKIWGAPWTPKYGNWAFQYPPGEDVWQGKIPGDADIVVTHGPAQGHLDVNGMGHAGCAWMGRELERVKPRLAVYGHIHESRGREYVRWDRVQRMYEGVLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CB98</accession>
    <name>A0A177CB98_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CC84DRAFT_1246722</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG04596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034961.1">
        <property type="nucleotide sequence ID" value="XM_018184210.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CB98"/>
    <dbReference type="GeneID" id="28767696"/>
    <dbReference type="InParanoid" id="A0A177CB98"/>
    <dbReference type="OrthoDB" id="3639251at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000018">
        <property type="entry name" value="MFS transporter permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF3">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="55"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="94"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="123"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="150"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="186"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="219"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="301"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="335"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="366"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="390"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="422"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="455"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAG04596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="500" mass="55669" checksum="63EDAEFAE49EBB63" modified="2016-09-07" version="1">MATGSKLDAVQIEDTSQKEHTVDESRLDRNIHLNDAIRAETDRDEKRVRKIIRRVDFRMVPILGLLYMWALIDRVNLPNIQIAGMGKELETTKGNRYTLVTMIFFVTYILFDYPSNIALRKLGAARWLGFIGTAWGCLTIAMGFVQSWKTLLVCRVIFGALEAGMAPGCIYLLGAWYTRYEVQKRFAAWACIGVFGSGISSALVYGITTIGRVGGLAAWRWIFIIEGIISAAIGILAGFILIDFPDRATRPGIFSKKGFLTPEEAAIVLARVERDRADAVPEPLNRRNVSRALQDWKMWQFPFLLFCNNLTVYSFSYFLPIILHDSMGYSTKMTYFLTIPPYVCAAIWMFAIGCLNDRLKVRGPTIIAQSLIITLGICIMAFASNAGARYFGVFLAVGGTNSNIPTIYGYQHNNLTGQTKRALATAMLLMGGGCGGIAASFAFQSKDAPDYIPGMITAITSQVVTVVLVSLNWLYFLHRNNKAEKGEVVLEQTPGFRYTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CC10</accession>
    <name>A0A177CC10_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1217796</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG04327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034692.1">
        <property type="nucleotide sequence ID" value="XM_018182933.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CC10"/>
    <dbReference type="GeneID" id="28766419"/>
    <dbReference type="InParanoid" id="A0A177CC10"/>
    <dbReference type="OrthoDB" id="3788217at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="28"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="158"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="238"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG04327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="260" mass="27214" checksum="8E108721E33FD874" modified="2016-09-07" version="1">MKATVRDLPSKTHATVPYRRKTLPAPPLVIYFFVILFSVICTPLSIAYGWQIYTAPTAAYINNTWAATGSGLLYYLPAPFTLGLAIFSTCLYRKRSVPILYSLATACTLLAGWLVVLVWWTQCHNDLYGDFMEDRWCYQRGLRSGRGRQTYRGVGDSLAYASMAFGCLLIIIFLLEIIGSGMELHKGRKVGVWRFAIPPKGRGKKGGRGTGSGGGDAVGAAGYGGFWAVDAGGGGGDDGGGGGGGGDGGGGGGGDGGGGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CC11</accession>
    <name>A0A177CC11_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mus7/MMS22 family-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1092940</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG05193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035558.1">
        <property type="nucleotide sequence ID" value="XM_018174492.1"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CC11"/>
    <dbReference type="GeneID" id="28757978"/>
    <dbReference type="InParanoid" id="A0A177CC11"/>
    <dbReference type="OrthoDB" id="2386201at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035361">
        <property type="term" value="C:Cul8-RING ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031297">
        <property type="term" value="P:replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019021">
        <property type="entry name" value="Mms22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28122">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SUBSTRATE RECEPTOR MMS22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28122:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SUBSTRATE RECEPTOR MMS22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09462">
        <property type="entry name" value="Mus7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="245"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="469"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="523"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="595"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="653"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="694"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="733"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="844"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="900"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="337"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="595"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="733"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="768"/>
            <end position="778"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG05193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2168" mass="243483" checksum="1C3CF9514B9A695A" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CC62</accession>
    <name>A0A177CC62_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Heterokaryon incompatibility</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1055019</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG05243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035608.1">
        <property type="nucleotide sequence ID" value="XM_018173529.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CC62"/>
    <dbReference type="STRING" id="1460663.A0A177CC62"/>
    <dbReference type="GeneID" id="28757015"/>
    <dbReference type="InParanoid" id="A0A177CC62"/>
    <dbReference type="OrthoDB" id="2958217at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF16">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG05243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="58" mass="6388" checksum="9FE04EBE7CB95187" modified="2016-09-07" version="1" fragment="single">LPRTINDAISVTEALSIYYLWIDALCIQQDAGEDKDTVIANMHNIYENSFITIAAASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CCG3</accession>
    <name>A0A177CCG3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1206090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG04400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034765.1">
        <property type="nucleotide sequence ID" value="XM_018182014.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CCG3"/>
    <dbReference type="GeneID" id="28765500"/>
    <dbReference type="InParanoid" id="A0A177CCG3"/>
    <dbReference type="OrthoDB" id="3797724at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="279"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="284"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="295"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG04400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="322" mass="36448" checksum="46382C535B3926DA" modified="2016-09-07" version="1">MPSSQKRKQKRADQQKKARDERRLALIHYPDAFSKKITLDAHTNLLNNLRDDEADYHDLSYVEQSIQVYDKAIGLFFDHLLMAAERARHLQHVVVTGDKEAALEHITTQLKASIDHGQKIAGLAYIEAATCCLHQEYSKHANPLQMEKVPAGVTVLGYFEETQTAYEDLNTALLTHMELCKGMGDAYESQILDETLDDAGAEKLNEVAAALEGAWRCYAVQQVHATVKAQFEEFSKRFFEDGRAHVEAVRVLDELEEGFEEPWGWVDRSELWLREWIEEGEGESTDKGENNRDGEVEDWMTDEEGSAEEENTGGEEGLTEGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CCT0</accession>
    <name>A0A177CCT0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">PQ-loop-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CC84DRAFT_800605</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Vacuole</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the laat-1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG04692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035057.1">
        <property type="nucleotide sequence ID" value="XM_018187464.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CCT0"/>
    <dbReference type="FunCoup" id="A0A177CCT0">
        <property type="interactions" value="347"/>
    </dbReference>
    <dbReference type="GeneID" id="28770950"/>
    <dbReference type="InParanoid" id="A0A177CCT0"/>
    <dbReference type="OrthoDB" id="8048523at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098588">
        <property type="term" value="C:bounding membrane of organelle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015174">
        <property type="term" value="F:basic amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015101">
        <property type="term" value="F:organic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034488">
        <property type="term" value="P:basic amino acid transmembrane export from vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034490">
        <property type="term" value="P:basic amino acid transmembrane import into vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.290:FF:000011">
        <property type="entry name" value="PQ loop repeat protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.290">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051415">
        <property type="entry name" value="LAAT-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006603">
        <property type="entry name" value="PQ-loop_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16201">
        <property type="entry name" value="SEVEN TRANSMEMBRANE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16201:SF35">
        <property type="entry name" value="VACUOLAR AMINO ACID TRANSPORTER YPQ1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04193">
        <property type="entry name" value="PQ-loop"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00679">
        <property type="entry name" value="CTNS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="4" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="14"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="48"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="78"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="205"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="245"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="285"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="327"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="107"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OAG04692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="368" mass="41200" checksum="9B61D2823B541541" modified="2016-09-07" version="1">MFPPSQGLRLDIDAISQICGSVSIACWIVVFSPQIIENWKRGSAEGLSVVFITVWLLGDFFNIFGAVLQGVLPTMTILAVYYTLADIVLLGQYFWYEGFRLTDRVGSREESEEEDEEPTERAPLLSPSLRDRHDLPENGFHTPPRISDADARRRGSAHSANSFRERFLSVSSNHLSPVTPLLDDPSLTPNKPPPRTQNPSALQAVFFNVGIIILVCASGVFGWWLSTTRSSATTPPPTEPSSEKLQFNLWGQIFGYICAALYLGSRIPQLLLNYRRKSTDGISMLFFLFACIGNLTYVLSIVAYKPLCRKPNHCREGEAMSIYGRYIAVNLSWLLGSFGTLLLDAGVFIQYFLYRKDEDSDSEEESAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CDC8</accession>
    <name>A0A177CDC8_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Steroid 5-alpha reductase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1218210</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG04787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035152.1">
        <property type="nucleotide sequence ID" value="XM_018182976.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CDC8"/>
    <dbReference type="GeneID" id="28766462"/>
    <dbReference type="InParanoid" id="A0A177CDC8"/>
    <dbReference type="OrthoDB" id="67965at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010721">
        <property type="entry name" value="UstE-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32251">
        <property type="entry name" value="3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32251:SF15">
        <property type="entry name" value="3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE (DUF1295)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06966">
        <property type="entry name" value="DUF1295"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="161"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="223"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG04787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="281" mass="30722" checksum="DE20CCC70455ED6C" modified="2016-09-07" version="1">MPSNLIPNTKGYDEARANDPRSEESKKKDLISRGDYTPTPVGKLVFVLARAIDPFIQYSILQGAGTGLLHQIGLRTLPPGIPSSTGISALDGLGLSPYRLVLLGMAVGSAVKQGIWAVAVSGEPMNVSNAIAISVFNTVFNSINSYAFIIRATSASLESDFPQPALLVGGALYVTGLLTEFISEVQRKRFKMDTKNKGKPYTGGLWSFARHINYGGYTIWRGAYALTGGGWIMGAIVGTFFFVDFARRGVPVLNEYCEKRYGEDWDKFKKQTKYRLIPGIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CDH5</accession>
    <name>A0A177CDH5_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_805753</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG04837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035202.1">
        <property type="nucleotide sequence ID" value="XM_018187493.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CDH5"/>
    <dbReference type="STRING" id="1460663.A0A177CDH5"/>
    <dbReference type="GeneID" id="28770979"/>
    <dbReference type="InParanoid" id="A0A177CDH5"/>
    <dbReference type="OrthoDB" id="3509362at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF15">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="10"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAG04837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="494" mass="54340" checksum="3ABA97B231918EDC" modified="2016-09-07" version="1">MAGHTRSRTGCWTCREAGYKCDEQKPSCGRCTRLKKECKGYGVKLKWRIATSAAVVPRKRFAKRSQSVGMVSVDSPASATSPLLVFSVFSAPTPASGASSYDHSESTLSPTMNPSVYPDLSRTNQRLLHYWLEQLAPLISAAPKDGGASSFQIHLASMTYTRGALQSTVLSMAAAHFGLVSGDTTLRFEAYRHQHEAIHLLQEAIQDPNEADSDPTLATVMMMQISARLFGDEEEAHAANHLTGAKAMISRRRARSGNMNSLSADFLNSLYAYHDILSSVSRGSSPLDAHGAEFTAIEGSAKMSSIAKILQVVARISTFHEAAKAERLLSQTSDLQGNNFNLGAELQQTLMNLTSNLDTVIPDIGFTAEAYRHAAFIYLYRVWLDMGSPNPTTLKHVQECLAYIGQVPVDSPLASSHVWPLFTAGCEAIDATQRKFVRLRFQAMYESRKFPSLKRVLRDIEDVWAVKDAEQMGGLKVDCIQVILRRRGREVDLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CEK1</accession>
    <name>A0A177CEK1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CC84DRAFT_832123</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS6 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG05197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035562.1">
        <property type="nucleotide sequence ID" value="XM_018187569.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CEK1"/>
    <dbReference type="FunCoup" id="A0A177CEK1">
        <property type="interactions" value="1066"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CEK1"/>
    <dbReference type="GeneID" id="28771055"/>
    <dbReference type="InParanoid" id="A0A177CEK1"/>
    <dbReference type="OrthoDB" id="10260596at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.2650">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001377">
        <property type="entry name" value="Ribosomal_eS6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014401">
        <property type="entry name" value="Ribosomal_eS6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018282">
        <property type="entry name" value="Ribosomal_eS6_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11502">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01092">
        <property type="entry name" value="Ribosomal_S6e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002129">
        <property type="entry name" value="Ribosom_S6_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01405">
        <property type="entry name" value="Ribosomal_S6e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00578">
        <property type="entry name" value="RIBOSOMAL_S6E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="217"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="218"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR002129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAG05197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="239" mass="27450" checksum="BE10DB67811497D9" modified="2016-09-07" version="1">MKLNISYPNNGTQKLIEIEDERKLRVFMDRRMGHEVPGDSVGDEFKGYIFRITGGNDKQGFPMKQGVMHPTRVRLLLADGHSCYRPRRTGERKRKSVRGCIVGMDLSVLALSIVKKGDADIPGVTDTVHPKRLGPKRATKLRRFFGLSKDDDVRKFVIRREVQPKKEGAKPYTKAPKIQRLVTPQRLQHKRHRVALKRRRAEASKDAANEYAQILHKRITEAKSAHDEAKKRRASSMRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CEY6</accession>
    <name>A0A177CEY6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative 3-oxoacyl-reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1090683</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG05886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036251.1">
        <property type="nucleotide sequence ID" value="XM_018174366.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CEY6"/>
    <dbReference type="STRING" id="1460663.A0A177CEY6"/>
    <dbReference type="GeneID" id="28757852"/>
    <dbReference type="InParanoid" id="A0A177CEY6"/>
    <dbReference type="OrthoDB" id="542013at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157:SF31">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG05886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="330" mass="36742" checksum="8EAE3BAA3D457DB3" modified="2016-09-07" version="1">MGGFLGFCYRQLTFKPKSLPTTISLEGKTALITGANSGLGLEAARELVAHKLSRLIIAVRDVSKGEAAKKSILESTKSTCEIEVWPLDYDFYDSIIEFQKRIEGLDRLDYALLNAGVKMMHYSTSPLGHETNVQINHLGTSAVSLVVLPTLKRTAQKLNSPVRLTIVSSEGHFWIPFKERTADNILKRMNDQETFGTQMQRYYTTKLLNVLWTRELSSKVPAGTIIINTVNPGFCYSGLHRHESSGIIKIFLWMFGWSSAEGGYCLTNALIQQENSHGKYLSEQRQTPPSPFVLSSEGQDVQQKVWRETIALLKEEAPGLDSSAVSPNIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CFH5</accession>
    <name>A0A177CFH5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS multidrug transporter-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_1187123</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG06096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036461.1">
        <property type="nucleotide sequence ID" value="XM_018180905.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CFH5"/>
    <dbReference type="GeneID" id="28764391"/>
    <dbReference type="InParanoid" id="A0A177CFH5"/>
    <dbReference type="OrthoDB" id="440553at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF43">
        <property type="entry name" value="MULTIDRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G03040)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01036">
        <property type="entry name" value="TCRTETB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="121"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="154"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="182"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="233"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="265"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="308"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="348"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="374"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="404"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="437"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="513"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="15"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="539"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="539"/>
            <end position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAG06096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="559" mass="60603" checksum="254FE05FA39B8038" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CGA4</accession>
    <name>A0A177CGA4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1145422</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG05780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036145.1">
        <property type="nucleotide sequence ID" value="XM_018176508.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CGA4"/>
    <dbReference type="STRING" id="1460663.A0A177CGA4"/>
    <dbReference type="GeneID" id="28759994"/>
    <dbReference type="InParanoid" id="A0A177CGA4"/>
    <dbReference type="OrthoDB" id="5337378at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="82"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG05780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="410" mass="46445" checksum="8AC791FEB9656BE9" modified="2016-09-07" version="1">MGKPHAARWRLPRPVHSRVSRIRVIGALLVLWMVCQLHLFSVYRDALSAKYGPTEFGILGAEQHYRPDSEAEKLQAELVASRSEWKKLGAGFEGTTYVLNDTVIKTFTPGRSPFRNCHPKHTTIRWPTEIPASLLFCSGSSGRNATSRVSRNAPTIGCLPVKAAFHTAAGPGMITQWHLVMPLARQGTLKSLSKNVQTQNLGFRILDARYRATFHELLRSLQILHETGFCHDDIKPDNIFVGEKQRWILGDLGNVRHVSHPYHKSRIWSDNMQLPDCRTNDAVRALKSYILFLRASSINVEALDEELFLGREPLSKLFLWMLDDATTMTAEELRERSSFKHPAQTVQVEAVHAVSSRPAWPSLLPYLSFRGQRLSRRVKHALNLSNSEMLARWKAMTWIFGIDQSVCSGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CGP5</accession>
    <name>A0A177CGP5_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alpha/beta-hydrolase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1259262</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG05940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036305.1">
        <property type="nucleotide sequence ID" value="XM_018184896.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CGP5"/>
    <dbReference type="STRING" id="1460663.A0A177CGP5"/>
    <dbReference type="GeneID" id="28768382"/>
    <dbReference type="InParanoid" id="A0A177CGP5"/>
    <dbReference type="OrthoDB" id="4605274at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053228">
        <property type="entry name" value="Stereospecific_Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37574">
        <property type="entry name" value="LIPASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37574:SF1">
        <property type="entry name" value="LIPASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG05940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="223" mass="23201" checksum="396AC867E31E7BAE" modified="2016-09-07" version="1">MSNIKGTDLSPPQTKHGASRLLAASFLVIGVHSVPTNSPKPESTIAIRAPVPEPQLLSSLVGGLVGTKGALTATLVQALNGTLTQLLHPMPTSSPKDTDDIFSYVQGIQGATIGEGSQGINSFTNINSAPPRTIYPRAEQMDAKFSVSELALRSAIFIPSTFQAANAPSPVLLVPGTATMGGVNFDGIFAKILQADPSNGQPVWLNIPEAMLGDDQANAEYIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CGQ5</accession>
    <name>A0A177CGQ5_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Carboxypeptidase</fullName>
            <ecNumber evidence="7">3.4.16.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CC84DRAFT_1217730</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the peptidase S10 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.-" evidence="7"/>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG06526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036891.1">
        <property type="nucleotide sequence ID" value="XM_018182923.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CGQ5"/>
    <dbReference type="STRING" id="1460663.A0A177CGQ5"/>
    <dbReference type="GeneID" id="28766409"/>
    <dbReference type="InParanoid" id="A0A177CGQ5"/>
    <dbReference type="OrthoDB" id="443318at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000118">
        <property type="entry name" value="Carboxypeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018202">
        <property type="entry name" value="Ser_caboxypep_ser_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF479">
        <property type="entry name" value="CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00131">
        <property type="entry name" value="CARBOXYPEPT_SER_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 7 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012181601" description="Carboxypeptidase" evidence="8">
        <location>
            <begin position="16"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAG06526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="552" mass="61525" checksum="8D4CCFAC3348EA61" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CGT2</accession>
    <name>A0A177CGT2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phospholipase/carboxylesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_743336</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG05990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036355.1">
        <property type="nucleotide sequence ID" value="XM_018187265.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CGT2"/>
    <dbReference type="STRING" id="1460663.A0A177CGT2"/>
    <dbReference type="GeneID" id="28770751"/>
    <dbReference type="InParanoid" id="A0A177CGT2"/>
    <dbReference type="OrthoDB" id="5358398at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048273">
        <property type="entry name" value="Luciferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040841">
        <property type="entry name" value="Luciferase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38695">
        <property type="entry name" value="AMINO ACID PERMEASE_ SLC12A DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38695:SF1">
        <property type="entry name" value="AMINO ACID PERMEASE_ SLC12A DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17648">
        <property type="entry name" value="Luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="Luciferase" evidence="2">
        <location>
            <begin position="177"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG05990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="260" mass="28894" checksum="A19AD805344210DB" modified="2016-09-07" version="1">MASQLQISITERPLLAAAGTIGIVFAAIAFRDYQNYCSLGPHGLPATFWGWYTQLKMTRMARKDVTVPAPYDIDNVAGPHDKEQFLPQDASRALKWRPGNKAPQIPNFVAPQRQTSDIASEELKKAMYSYLDMLVESHNSVLQTQKSILEGPVPAVGIKNFASLPDAKKPDVYRSTRGEIIHIHPPDGSTHLIMSLADQKSVIETGWGRRHRLSGGGRLPWNYTFTYAPRNEMEFVVWKTLVGAAVEFCLANSAGRADQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CGZ4</accession>
    <name>A0A177CGZ4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Elongation factor 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CC84DRAFT_1145760</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG05977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036342.1">
        <property type="nucleotide sequence ID" value="XM_018176525.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CGZ4"/>
    <dbReference type="FunCoup" id="A0A177CGZ4">
        <property type="interactions" value="1145"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CGZ4"/>
    <dbReference type="GeneID" id="28760011"/>
    <dbReference type="InParanoid" id="A0A177CGZ4"/>
    <dbReference type="OrthoDB" id="364892at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01681">
        <property type="entry name" value="aeEF2_snRNP_like_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04096">
        <property type="entry name" value="eEF2_snRNP_like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01885">
        <property type="entry name" value="EF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16261">
        <property type="entry name" value="EF2_snRNP_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03700">
        <property type="entry name" value="EF2_snRNP_like_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000010">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000006">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.240:FF:000003">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.870:FF:000002">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000058">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.870">
        <property type="entry name" value="Elongation Factor G (Translational Gtpase), domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041095">
        <property type="entry name" value="EFG_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005517">
        <property type="entry name" value="Transl_elong_EFG/EF2_IV"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908:SF10">
        <property type="entry name" value="EUKARYOTIC TRANSLATION ELONGATION FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908">
        <property type="entry name" value="TRANSLATION ELONGATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14492">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03764">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00889">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="EF-G C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="9">
        <location>
            <begin position="17"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAG05977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="843" mass="93932" checksum="425345C400CFDBEB" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CH63</accession>
    <name>A0A177CH63_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cryptochrome/photolyase FAD-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CC84DRAFT_1258150</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="4">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA photolyase class-1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG06913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037278.1">
        <property type="nucleotide sequence ID" value="XM_018184796.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CH63"/>
    <dbReference type="STRING" id="1460663.A0A177CH63"/>
    <dbReference type="GeneID" id="28768282"/>
    <dbReference type="InParanoid" id="A0A177CH63"/>
    <dbReference type="OrthoDB" id="435881at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003904">
        <property type="term" value="F:deoxyribodipyrimidine photo-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032922">
        <property type="term" value="P:circadian regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043153">
        <property type="term" value="P:entrainment of circadian clock by photoperiod"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.579.10">
        <property type="entry name" value="DNA Cyclobutane Dipyrimidine Photolyase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036134">
        <property type="entry name" value="Crypto/Photolyase_FAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036155">
        <property type="entry name" value="Crypto/Photolyase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005101">
        <property type="entry name" value="Cryptochr/Photolyase_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002081">
        <property type="entry name" value="Cryptochrome/DNA_photolyase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006050">
        <property type="entry name" value="DNA_photolyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11455">
        <property type="entry name" value="CRYPTOCHROME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11455:SF18">
        <property type="entry name" value="SI:CH1073-390K14.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00875">
        <property type="entry name" value="DNA_photolyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03441">
        <property type="entry name" value="FAD_binding_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00147">
        <property type="entry name" value="DNAPHOTLYASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48173">
        <property type="entry name" value="Cryptochrome/photolyase FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52425">
        <property type="entry name" value="Cryptochrome/photolyase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51645">
        <property type="entry name" value="PHR_CRY_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0274">FAD</keyword>
    <keyword evidence="2 4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Photolyase/cryptochrome alpha/beta" evidence="6">
        <location>
            <begin position="47"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="286"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="298"/>
            <end position="302"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="341"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="344"/>
            <end position="351"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="442"/>
            <end position="444"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR602081-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAG06913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="534" mass="61917" checksum="2D4E131B6F7DA0AF" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CHI6</accession>
    <name>A0A177CHI6_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1089157</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG07025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037390.1">
        <property type="nucleotide sequence ID" value="XM_018174289.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CHI6"/>
    <dbReference type="STRING" id="1460663.A0A177CHI6"/>
    <dbReference type="GeneID" id="28757775"/>
    <dbReference type="InParanoid" id="A0A177CHI6"/>
    <dbReference type="OrthoDB" id="6359816at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="20"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG07025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="298" mass="33087" checksum="32A3591D7669A890" modified="2016-09-07" version="1">MAAENFIRDISTYLTAGNFSDLTLQFGERTWKIHKAIACCHSKWFHNVMTIGFKVSTCTCESIQETETNVITLEDDGEMADALDCMVSYFYEAGYDTSKYSTPGTLLHAQVAVVADKYDCPSLYKLASASFAKQVPSVKSDDWIDIAALIYDYTTLELTTHSELRSLVINSVLSRPDMLTTILEKDTMVDILRSNADLATDLLLARPKTRDTSEHLFMCDKCQYVHAGPRDCAYIESRNGAGMGRACPNCGVKDHGPLSKRYYHKVFLAQGFPCSSCGGTHTTEPAPEPQSSMMDVQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2023-06-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CHN5</accession>
    <name>A0A177CHN5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1217588</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG06359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036724.1">
        <property type="nucleotide sequence ID" value="XM_018182910.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CHN5"/>
    <dbReference type="GeneID" id="28766396"/>
    <dbReference type="InParanoid" id="A0A177CHN5"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG06359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="149" mass="16654" checksum="D9FE30A5633AAD90" modified="2016-09-07" version="1">MRGIKTPVPAQGDMELSSLVFNFETSYTMDDDTSCNIMEFGSLQKIIKRKTDLDLVPVPLPSMREVINGESGSWLANTSWNTRFETLDRLLKRKAYADLVADSIAGHRKDDKARVKDGGEHEIACAHKELGSLWSGQPAEVKFSILGYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CJ42</accession>
    <name>A0A177CJ42_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PLP-dependent transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_629874</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG06878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037243.1">
        <property type="nucleotide sequence ID" value="XM_018186939.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CJ42"/>
    <dbReference type="STRING" id="1460663.A0A177CJ42"/>
    <dbReference type="GeneID" id="28770425"/>
    <dbReference type="InParanoid" id="A0A177CJ42"/>
    <dbReference type="OrthoDB" id="7042322at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43510">
        <property type="entry name" value="AMINOTRANSFERASE FUNCTION, HYPOTHETICAL (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43510:SF1">
        <property type="entry name" value="AMINOTRANSFERASE FUNCTION, HYPOTHETICAL (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="3">
        <location>
            <begin position="48"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAG06878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="400" mass="44557" checksum="96C2A945162309AA" modified="2016-09-07" version="1">MVKIARFSVEAWMDKYEHSCKYNIAETCCASISIDQLRELSEDKDRDVVTTSTALTYGAIRGADALRDNLARLYSARSGKVLPRDNILTTNGAIQANYLIAYALLGPGDHVICHYPTYQSLYEIPKQLGAEVSLWKASPENKWSPSIDHLKTLIKPNTKMIIINNPHNPTGAVLGKSFLQQVIDIASEHNIIIHSDEVYRPIFHGITPMDAEFPPSIVSMGYERVIATGSMSKAYSLAGIRIGWIASRDRSIIEEIAEARHYTLISVSMLDEQVAAFALDPSTIHSLLARNIALAKTNVEIMEKFVLKNDDACDWVKPVAGTTAFVRFHRDGKPVDSVDFCEKLLEKTGVMFVPGSDCFGQDFKGYVRIGYVNHTEGVKEGLDKVTQFVRRNLDDVKLAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CJX6</accession>
    <name>A0A177CJX6_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Endoglucanase EG-II</fullName>
            <ecNumber evidence="3">3.2.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CC84DRAFT_634914</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Endoglucanase (EG) that cleaves the internal beta-1,4-glucosidic bonds in cellulose. The degradation of cellulose involves an interplay between different cellulolytic enzymes. Hydrolysis starts with EGs, which cut internal glycosidic linkages to reduce the polymerization degree of the substrate and creates new chain ends for exocellobiohydrolases (CBHs). The CBH release the disaccharide cellobiose from the non-reducing end of the cellulose polymer chain. Finally, beta-1,4-glucosidases hydrolyze the cellobiose and other short cello-oligosaccharides into glucose units.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endohydrolysis of (1-&gt;4)-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans.</text>
            <dbReference type="EC" id="3.2.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.4" evidence="3"/>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG07097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037462.1">
        <property type="nucleotide sequence ID" value="XM_018186973.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CJX6"/>
    <dbReference type="STRING" id="1460663.A0A177CJX6"/>
    <dbReference type="GeneID" id="28770459"/>
    <dbReference type="InParanoid" id="A0A177CJX6"/>
    <dbReference type="OrthoDB" id="5823761at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008810">
        <property type="term" value="F:cellulase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000124">
        <property type="entry name" value="Exported cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018087">
        <property type="entry name" value="Glyco_hydro_5_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34142:SF5">
        <property type="entry name" value="CBM1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34142">
        <property type="entry name" value="ENDO-BETA-1,4-GLUCANASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00659">
        <property type="entry name" value="GLYCOSYL_HYDROL_F5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="9 13" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 13 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="8" id="KW-0873">Pyrrolidone carboxylic acid</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 14" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008058277" description="Endoglucanase EG-II" evidence="14">
        <location>
            <begin position="18"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 5" evidence="15">
        <location>
            <begin position="63"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00059691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00074271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OAG07097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="353" mass="37481" checksum="36A1AE694F9C0478" modified="2016-09-07" version="1">MKASLFALTSLATFAVSSPTPRANKVQYAGVNIAGFDFGCTIDGTCSLTGTNKPYDIVSGANAVGQMNHFVKDDSLNAFRLPVGWQFLVNGQLGGQLNSNNAGQYDRLVQGCLNSGAALCILDIHNYARWNGQIVGQGGPSNAQLADVWKQLATKYGKQSKIAFGVMNEPHDIPDIKAWAATVQAVVTAIRNAGASNNLILLPGNGFTSAESFVSSGSAAALAAVTNPDGSINNLIMDVHKYLDSDNSGTHTECVKDNISNAFQPLADWLRSNKRQAILTETGGGNTQSCQQYLCSQLKYLNQNADVYIGYTGWAAGGFASSYELNETPTQNGNSWSDTSLVKSCIVGVWKGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CJY9</accession>
    <name>A0A177CJY9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CC84DRAFT_1238796</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG07835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038200.1">
        <property type="nucleotide sequence ID" value="XM_018183958.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CJY9"/>
    <dbReference type="STRING" id="1460663.A0A177CJY9"/>
    <dbReference type="ESTHER" id="9pleo-a0a177cjy9">
        <property type="family name" value="Fungal_carboxylesterase_lipase"/>
    </dbReference>
    <dbReference type="GeneID" id="28767444"/>
    <dbReference type="InParanoid" id="A0A177CJY9"/>
    <dbReference type="OrthoDB" id="6846267at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43142">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43142:SF1">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="23"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAG07835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="572" mass="63139" checksum="5558318938E0E6AF" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CK76</accession>
    <name>A0A177CK76_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF1996 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1163491</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG07278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037643.1">
        <property type="nucleotide sequence ID" value="XM_018178276.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CK76"/>
    <dbReference type="GeneID" id="28761762"/>
    <dbReference type="InParanoid" id="A0A177CK76"/>
    <dbReference type="OrthoDB" id="74764at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018535">
        <property type="entry name" value="DUF1996"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43662">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43662:SF5">
        <property type="entry name" value="DUF1996 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09362">
        <property type="entry name" value="DUF1996"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1996" evidence="1">
        <location>
            <begin position="7"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG07278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="278" mass="30687" checksum="CC5F956B11033D7C" modified="2016-09-07" version="1" fragment="single">MTGDIGNQGTCTTCTFSEDFSNYWTAVLFFKHTNGSYKRVKIMENDALPAGINGGMTIYYTQKDFNSNGNQKITAFPPGFRMTVGSPTQGKDGMTKHKGLRFTCLDTKSTRFPEIDDFPKKPCKGGIMTEHHFPACWDGKNLDSPDHQAHMYDTQPTGFAAGAACPSSHPVRVPQLAYETLWDTAEFKDMWPKDGSNPFVFSYGGQDGHAYGTHADYMFGWKGDALQRAMDSSCMFTACENGKPLKSQSVSQMNACKAKEIVNESHDGWLKALPGMTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2023-06-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CKA0</accession>
    <name>A0A177CKA0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1203464</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG07945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038310.1">
        <property type="nucleotide sequence ID" value="XM_018181830.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CKA0"/>
    <dbReference type="GeneID" id="28765316"/>
    <dbReference type="InParanoid" id="A0A177CKA0"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG07945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="241" mass="27449" checksum="C650F8CBB1F84998" modified="2016-09-07" version="1">MRLEFYDIRQAQKEENNLLNDFATMAEQMKLLVATRGSAMEALAAAHLEEVKKLKQPHAVELDAIKKQHKAEVTKMIGEQDYCGSAREMRTERRRKLRVSHNAAFASLPGNMVVKIKNVFAQDQKQKAELYCAFQGLEMHQQELLLEIQSRVSQEKTVRLTLLDCHADTLAEAHKLQLENAPKFIESCVTVHDLAQKYILEGEKQAEANDKIWEALKSQDNKTCAGTWRISSRTLLQGDLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CKG9</accession>
    <name>A0A177CKG9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1143872</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG07368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037733.1">
        <property type="nucleotide sequence ID" value="XM_018176435.1"/>
    </dbReference>
    <dbReference type="GeneID" id="28759921"/>
    <dbReference type="InParanoid" id="A0A177CKG9"/>
    <dbReference type="OrthoDB" id="3248909at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021840">
        <property type="entry name" value="DUF3433"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37544:SF3">
        <property type="entry name" value="SPRAY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37544">
        <property type="entry name" value="SPRAY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11915">
        <property type="entry name" value="DUF3433"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="115"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="185"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="572"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="688"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="730"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="802"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1326"/>
            <end position="1347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="974"/>
            <end position="996"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="974"/>
            <end position="991"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG07368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="1421" mass="158478" checksum="305B716797E3BEC9" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CKN7</accession>
    <name>A0A177CKN7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1173656</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038469.1">
        <property type="nucleotide sequence ID" value="XM_018180049.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CKN7"/>
    <dbReference type="GeneID" id="28763535"/>
    <dbReference type="InParanoid" id="A0A177CKN7"/>
    <dbReference type="OrthoDB" id="5424391at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG08104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="428" mass="47499" checksum="67020730CB0F4775" modified="2016-09-07" version="1">MQAAVARRALSSLASKIHPQLPLTPRESQQLLNLLTTSFRSHLDREYPAGPSEAPPASTTTQLVKVEQSRRLSSSYDSASEHIDSILSNPLFARKPSRRGSDSAAANALNDPFAWFLDQAAIGTADIPKAALCLDLLQRAQNKTKGRRGSISNGDRRPASVIAEWLRTSGEETSKAFLISQLPAKGAPRRSLVNRLVPLLLTEGNHAPLWRWYTYEPEEGDMLNQAQLSPFKCQLLKEMVNGARTRDEAFAIFQHAFQLAEAGKNKAYVNSLQVAGARLVDLIVADSQIPCTPELYEQFALSTHGWLFAWKPVVQAMLCLCHPTNPDPQPALKIIKNADSFLASTHSKPSRQRFFVRMCLGAAQQLIKEEKLADAQIAMQFTKEHFEDLVLIKYHSSAPHQTNRGVSEQKKTQDEKRNIALLDGFLAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CKS0</accession>
    <name>A0A177CKS0_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RNA polymerase II degradation factor 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CC84DRAFT_1162102</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Telomere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DEF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038468.1">
        <property type="nucleotide sequence ID" value="XM_018177909.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CKS0"/>
    <dbReference type="STRING" id="1460663.A0A177CKS0"/>
    <dbReference type="GeneID" id="28761395"/>
    <dbReference type="InParanoid" id="A0A177CKS0"/>
    <dbReference type="OrthoDB" id="5396806at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14368">
        <property type="entry name" value="CUE_DEF1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003892">
        <property type="entry name" value="CUE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041803">
        <property type="entry name" value="DEF1_CUE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051833">
        <property type="entry name" value="TC-DDR_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16308:SF13">
        <property type="entry name" value="PROTEIN LINGERER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16308">
        <property type="entry name" value="UBIQUITIN ASSOCIATED PROTEIN 2-LIKE/LINGERER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02845">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51140">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="14" id="KW-0234">DNA repair</keyword>
    <keyword evidence="13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0779">Telomere</keyword>
    <keyword evidence="11" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="10" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="CUE" evidence="17">
        <location>
            <begin position="54"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="92"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="231"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="348"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="413"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="720"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="102"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="135"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="16">
        <location>
            <begin position="153"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="171"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="197"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="232"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="249"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="306"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="324"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="366"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="418"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="482"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="546"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="571"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="583"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="595"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="631"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="654"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="727"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="767"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="800"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="838"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="16">
        <location>
            <begin position="871"/>
            <end position="884"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="OAG08103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="917" mass="94952" checksum="1DC5EAB1982BB30D" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CL17</accession>
    <name>A0A177CL17_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1256879</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG07921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038286.1">
        <property type="nucleotide sequence ID" value="XM_018184675.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CL17"/>
    <dbReference type="GeneID" id="28768161"/>
    <dbReference type="InParanoid" id="A0A177CL17"/>
    <dbReference type="OrthoDB" id="10418680at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG07921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="123" mass="13465" checksum="2DB422EA82E35F06" modified="2016-09-07" version="1">MLNSTQPLHHTINTRFRNTRVSLPLFKMRVSTIAFILTLAAGGLAGAAIKHDDAPTVTPSGGAGHPTTTPIPKVADGRCTPCNDHMEQCMGKWPCWFYNCQPDCNHEVCEQLPDCRQGCGFHC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CL19</accession>
    <name>A0A177CL19_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CC84DRAFT_1216436</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus envelope</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleoporin Nup133 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG07487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037852.1">
        <property type="nucleotide sequence ID" value="XM_018182803.1"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CL19"/>
    <dbReference type="GeneID" id="28766289"/>
    <dbReference type="InParanoid" id="A0A177CL19"/>
    <dbReference type="OrthoDB" id="103454at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031080">
        <property type="term" value="C:nuclear pore outer ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000972">
        <property type="term" value="P:transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007187">
        <property type="entry name" value="Nucleoporin_Nup133/Nup155_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014908">
        <property type="entry name" value="Nucleoporin_Nup133/Nup155_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037624">
        <property type="entry name" value="Nup133-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13405">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13405:SF11">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03177">
        <property type="entry name" value="Nucleoporin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08801">
        <property type="entry name" value="Nucleoporin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117289">
        <property type="entry name" value="Nucleoporin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0811">Translocation</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nucleoporin Nup133/Nup155-like N-terminal" evidence="11">
        <location>
            <begin position="107"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoporin Nup133/Nup155-like C-terminal" evidence="10">
        <location>
            <begin position="628"/>
            <end position="1299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1312"/>
            <end position="1362"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="1034"/>
            <end position="1061"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="1353"/>
            <end position="1362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OAG07487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="1362" mass="152051" checksum="0F1FE4488B1323B7" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CL84</accession>
    <name>A0A177CL84_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methionine synthase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_564230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038638.1">
        <property type="nucleotide sequence ID" value="XM_018186711.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CL84"/>
    <dbReference type="STRING" id="1460663.A0A177CL84"/>
    <dbReference type="GeneID" id="28770197"/>
    <dbReference type="InParanoid" id="A0A177CL84"/>
    <dbReference type="OrthoDB" id="7772923at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003871">
        <property type="term" value="F:5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03311">
        <property type="entry name" value="CIMS_C_terminal_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002629">
        <property type="entry name" value="Met_Synth_C/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038071">
        <property type="entry name" value="UROD/MetE-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43844">
        <property type="entry name" value="METHIONINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43844:SF2">
        <property type="entry name" value="SYNTHASE, VITAMIN-B12 INDEPENDENT, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12060)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01717">
        <property type="entry name" value="Meth_synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51726">
        <property type="entry name" value="UROD/MetE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cobalamin-independent methionine synthase MetE C-terminal/archaeal" evidence="1">
        <location>
            <begin position="184"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG08273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="406" mass="46224" checksum="B8EDB82C12E546FA" modified="2016-09-07" version="1">MSAAKRSPPFRAEHVGSLLRPQELVQKRYDVAAGKAPASELIPLEDKLIEQVIKTQKDAGLHVVSSGEYTRHMFWGTFFEELNGMKELQLGVLKGYDQDMFRMYAPDVKSFFESKEVPNQVTVCTGKISHPGHSSNQREVDIMKKLVPESEWKNIKITLISPSWYHFRYRAGQAYPKEVYANDEEYFEDVAKAYQAELKFLHDQGIRNIQIDDPNLAYFCSEAMLEGWAADKGNDKTADEMFDAYVQFYNKCFERPEDMHLGIHLCRGNYVGSRHFSEGAYDKIAKKLFQDLNVDTYYLEYDTPRAGGFEPLTYLPKNKNAVLGVVTSKFPELENKDEMVARVNQAADFVAKGTGQSKEDALQQLCVSPQCGFASHAEGNALGYEDMRKKLQLVRSIADELWPGQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CL99</accession>
    <name>A0A177CL99_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CC84DRAFT_1086504</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038376.1">
        <property type="nucleotide sequence ID" value="XM_018174166.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CL99"/>
    <dbReference type="STRING" id="1460663.A0A177CL99"/>
    <dbReference type="GeneID" id="28757652"/>
    <dbReference type="InParanoid" id="A0A177CL99"/>
    <dbReference type="OrthoDB" id="9332038at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000078">
        <property type="entry name" value="Serine/threonine-protein kinase PRP4 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050494">
        <property type="entry name" value="Ser_Thr_dual-spec_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058:SF103">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE PRP4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="453"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="280"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="17"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="43"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="175"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="195"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="293"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="329"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="342"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="488"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OAG08011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="809" mass="90394" checksum="4F9F95F40C692E88" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CME9</accession>
    <name>A0A177CME9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_524115</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG07937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038302.1">
        <property type="nucleotide sequence ID" value="XM_018186628.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CME9"/>
    <dbReference type="GeneID" id="28770114"/>
    <dbReference type="InParanoid" id="A0A177CME9"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG07937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="123" mass="14056" checksum="6B55D711211A859F" modified="2016-09-07" version="1">MIEHIKTDIVESRTLMISLMVACSRSDSFCRQWRSFIWYRYTMQPSGQLALDARAERGWLQAVTHSRRKILSDDPVSWLASSGGIAVSRCAEQPLPQQARGARNRLDRACEAATRPLYEEGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CNC1</accession>
    <name>A0A177CNC1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_1162634</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039151.1">
        <property type="nucleotide sequence ID" value="XM_018178047.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CNC1"/>
    <dbReference type="STRING" id="1460663.A0A177CNC1"/>
    <dbReference type="GeneID" id="28761533"/>
    <dbReference type="InParanoid" id="A0A177CNC1"/>
    <dbReference type="OrthoDB" id="294295at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051122">
        <property type="entry name" value="SDR_DHRS6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057571">
        <property type="entry name" value="SDR_PhqE-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43477">
        <property type="entry name" value="DIHYDROANTICAPSIN 7-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43477:SF1">
        <property type="entry name" value="DIHYDROANTICAPSIN 7-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23441">
        <property type="entry name" value="SDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAG08786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="262" mass="27730" checksum="F8486BF0F928FAFB" modified="2016-09-07" version="1">MAHPNRLQNARVLVFGGTSGIGYGVASMALSNGAIVTISGSAQPKADAKAAELQSLYPSASVRGVALDLSDTANLEANLKALFEKVTNGGEQKLDHIVHCAGDALFLPKIHEVSADNALQGFNVRWLTSVLIGKLLATGTYMNAATSSSFTLTGGTNTTKPMEGWSIGASWGGASEGLMRGLAVDLKPIRVNLMAPGAIDTPLFQKFVDNVGREKEAEIKKAYTLLQTWGDVRDIAEGYGWFMRDHYVTGTIASSDGGRLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CP82</accession>
    <name>A0A177CP82_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1257822</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG09106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039471.1">
        <property type="nucleotide sequence ID" value="XM_018184765.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CP82"/>
    <dbReference type="GeneID" id="28768251"/>
    <dbReference type="InParanoid" id="A0A177CP82"/>
    <dbReference type="OrthoDB" id="5428890at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="320"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG09106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="361" mass="41062" checksum="1D596DECC29B8A9B" modified="2016-09-07" version="1">MSRSGPFIVAVREDFHAATRASNLELIYTIWANTGLSLENFRQKEYTAFLAYLSQESSYMEQNQRQFATDSVNGAIALVPLLRNNVSAPRHEVLAICQERFPGVDESILTRTIELAARIWLTTRVALVDSIMAVVKTNYRMLEWPAEISLREAVQSQFTFEDPADKMDILFGPDLDPSLTASALVEICGVKLSWTSNLMDHLQLDKRHRVLTVYEHKICLLNHTKGIDSPYPVDLLHETIDTLNLLFPFGHGPTKDLLRKENKLSLYGLGTCNRERRLKVADYRVWRTQITGLIEVFNEPPRNWWQLLSDRRDLRGWATFWLGPMVLLLTIVSIVTGTVSSVYAVKQYNLARAQACAACAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CPW7</accession>
    <name>A0A177CPW7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_597760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039295.1">
        <property type="nucleotide sequence ID" value="XM_018186816.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CPW7"/>
    <dbReference type="GeneID" id="28770302"/>
    <dbReference type="InParanoid" id="A0A177CPW7"/>
    <dbReference type="OrthoDB" id="3641178at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="209"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG08930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="270" mass="31223" checksum="74D66D07A2395142" modified="2016-09-07" version="1">MIPESQYCQMQAVMPEVKQLFQSRRYIQCANVCERFLSHHYDEIHPVHRVYLHFYFALVHDTMARETTLKHRSTGLELAEHHYRAAIEILTPSEPYNLDDLLSPLSPTSEYLSAAGFHRLSRLSFRSAASSMSEDEDRNWDRVDSPYDDTPSPTHSFRSGKPRPTPITTFNASRAYHEDRFSAELFALLPMLHAHLRGVKQLKSDKTTPRCSFSRSRTSTWSSRPQSRDSTGSNESELDQLRSMRKNLNFRPKFDPADIQKLCNEALAEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CPZ1</accession>
    <name>A0A177CPZ1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1160719</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG09595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039960.1">
        <property type="nucleotide sequence ID" value="XM_018177564.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CPZ1"/>
    <dbReference type="STRING" id="1460663.A0A177CPZ1"/>
    <dbReference type="GeneID" id="28761050"/>
    <dbReference type="InParanoid" id="A0A177CPZ1"/>
    <dbReference type="OrthoDB" id="20872at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1020">
        <property type="entry name" value="Prion-inhibition and propagation, HeLo domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029498">
        <property type="entry name" value="HeLo_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038305">
        <property type="entry name" value="HeLo_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031469">
        <property type="entry name" value="SesB_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37542">
        <property type="entry name" value="HELO DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37542:SF3">
        <property type="entry name" value="PRION-INHIBITION AND PROPAGATION HELO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14479">
        <property type="entry name" value="HeLo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17046">
        <property type="entry name" value="Ses_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prion-inhibition and propagation HeLo" evidence="1">
        <location>
            <begin position="6"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="Fungal death-pathway protein SesB" evidence="2">
        <location>
            <begin position="235"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG09595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="264" mass="28920" checksum="D19A0CD2220FC901" modified="2016-09-07" version="1">MVEAAGLVVGVVALAGLFNNTVECFEFVQLGRTFGKDFQTSQLKLDNARLRLSRWGKSLDLDEDVRNTTSLQGRFGSESTIKHAEALLGQIVELFAGAEGVSNSYKNRTAPQDDSLAVYNPQTDLDPAMAKLHDKMRQLAIERQNRSGIRQKAKWALYQEKHFRRLIEDITELVDSLVELFPATQQAQRELCDTEVSAIGESEAISVLKEVAAAQDQFLEQAITKTTDGADKSHHIIFSGSGNTGLQIGHNSGTMSGFTFGKGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CQB7</accession>
    <name>A0A177CQB7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_605890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG09090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039455.1">
        <property type="nucleotide sequence ID" value="XM_018186855.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CQB7"/>
    <dbReference type="GeneID" id="28770341"/>
    <dbReference type="InParanoid" id="A0A177CQB7"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG09090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="89" mass="10461" checksum="F83AAD651540679A" modified="2016-09-07" version="1">MRCQRSDVRMLLLTRRFQPSSVQCSFQQHANQLSFDSRRINRRCRRTFVAITTMFRIFCFLLCCNPDSFNRHTRLLGKRADGDVSGTLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CRG7</accession>
    <name>A0A177CRG7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Ras-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CC84DRAFT_1137895</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rho family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG09886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040251.1">
        <property type="nucleotide sequence ID" value="XM_018176171.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CRG7"/>
    <dbReference type="STRING" id="1460663.A0A177CRG7"/>
    <dbReference type="GeneID" id="28759657"/>
    <dbReference type="InParanoid" id="A0A177CRG7"/>
    <dbReference type="OrthoDB" id="8830751at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000935">
        <property type="term" value="C:division septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000917">
        <property type="term" value="P:division septum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000678">
        <property type="entry name" value="Rho GTPase Rho4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0488">Methylation</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0636">Prenylation</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="244"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="271"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAG09886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="282" mass="31338" checksum="4F7D765344C9E02F" modified="2016-09-07" version="1">MSATTAPSQNYDYLRRKQSTKAPISSVTPARRPIRTPSERNSNGTVSSYATTATRDTNITEPPTYSKKLVVVGDGGCGKTCLLISYSTGNFPEKYVPTVFENYITHTPHPPTGKMVELALWDTAGQEEYDRLRPLSYPETDIIFVCFAIDCPNSLENVMDKWYPEVLHFCPTTPLMLLGLKSDLRNKRSCIELLKTQGLTPVTPEQGRAVARKMGALYMECSSKEQDGVEEIFDRAVTEAVGDEYKEPEITSHSVAPGAPRADKRFPSGGKKTKKREKCTIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CRY9</accession>
    <name>A0A177CRY9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1138226</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040421.1">
        <property type="nucleotide sequence ID" value="XM_018176185.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CRY9"/>
    <dbReference type="GeneID" id="28759671"/>
    <dbReference type="InParanoid" id="A0A177CRY9"/>
    <dbReference type="OrthoDB" id="3747670at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008058517" evidence="2">
        <location>
            <begin position="23"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG10056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="317" mass="34313" checksum="D10BB9ABA1A066B2" modified="2016-09-07" version="1">MRTSLPSIILLLAASSIFAAQAQNTTNTTSTPETCGGDIDWLNTGNSSANSTGQVEFRWTDNSDSERPTSDLWYLSVTVNDTLRRGDVRTSASNGGIELRGYVSVPDDVKNASLCLYQFSSANVTLDDSIDDGLDSCGGIVSEECKDFIKDNFLHEIQPSGCPLYRKAGTEGADTFRKACPNLADSAAVYYKDVSNTTCATTDIPSVNIPEGYHSLRSASMSSPFSDYNYRPNMTEAYDLLVRQTVPYVLHSRFEDPDSNSMKVLTRFICVAPNRTVEGSRAVPDGKAPWEESKGVGLAAGRMAVVMTSIIGAVLMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CS03</accession>
    <name>A0A177CS03_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CC84DRAFT_1160681</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG09549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039914.1">
        <property type="nucleotide sequence ID" value="XM_018177554.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CS03"/>
    <dbReference type="STRING" id="1460663.A0A177CS03"/>
    <dbReference type="GeneID" id="28761040"/>
    <dbReference type="InParanoid" id="A0A177CS03"/>
    <dbReference type="OrthoDB" id="2094832at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051654">
        <property type="entry name" value="Meroterpenoid_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35897">
        <property type="entry name" value="METHYLTRANSFERASE AUSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35897:SF1">
        <property type="entry name" value="METHYLTRANSFERASE AUSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase" evidence="5">
        <location>
            <begin position="108"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAG09549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="299" mass="33872" checksum="F4FB5B8E224A82F8" modified="2016-09-07" version="1">MSLNKTPDLSVAANLLKGSPWENLPLDKLPWYSPEIEEITPQAQELFEKYSNVEPEKVKAHIKELRDKAYVVFPYPCLARWAFLELSVSLSRQYPEVLERVRNGDKYLDLGCCVGQDIRKLVFDGAPSENTFGSDLEKNFMDIGYDLFLDKQTLKTTFIAADIFDEDSDMKQIAGDIDIIHAASFLHLFDEEGQHKACENIVKLLKSKPGSLFIGRQIGNSESGVHVGLIDSSKKRYRHNAESFEQMWKSVGEKTGTKWKVEARLEDRDLHAVAEKMGLESATIPPGSKWLSFAVRRGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2023-06-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CS53</accession>
    <name>A0A177CS53_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_482481</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040728.1">
        <property type="nucleotide sequence ID" value="XM_018186448.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CS53"/>
    <dbReference type="GeneID" id="28769934"/>
    <dbReference type="InParanoid" id="A0A177CS53"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG10363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="156" mass="17723" checksum="2EE900FCCDBF1DF3" modified="2016-09-07" version="1">MWSRPGSEKRGVQKKTGTFAGLCSIHDVKIADVWFSGKTLWRIFFRQMAPARPGRLMLMAWDVAEYQSRYAVSWQRRSMVELLSVDLPTLLSCTRLRLLHSYTKTHPASTTSLSPSPRAGKCILTRPVARRRQSGWLASLAWRGVPVVERRAPSPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CSK1</accession>
    <name>A0A177CSK1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">TIM-barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1193541</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG09912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040277.1">
        <property type="nucleotide sequence ID" value="XM_018181311.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CSK1"/>
    <dbReference type="STRING" id="1460663.A0A177CSK1"/>
    <dbReference type="GeneID" id="28764797"/>
    <dbReference type="InParanoid" id="A0A177CSK1"/>
    <dbReference type="OrthoDB" id="10264588at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.460">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009215">
        <property type="entry name" value="TIM-br_IGPS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051353">
        <property type="entry name" value="Tobamovirus_resist_UPF0261"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31862">
        <property type="entry name" value="UPF0261 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G10120)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31862:SF1">
        <property type="entry name" value="UPF0261 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G10120)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09370">
        <property type="entry name" value="PEP_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF034452">
        <property type="entry name" value="TIM-br_sig_trnsd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TIM-barrel" evidence="1">
        <location>
            <begin position="9"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG09912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="279" mass="29837" checksum="7BEE6CF23AF7A171" modified="2016-09-07" version="1">MAPPNDRKEILDNLRKLISDGTVIVGAGAGIGLSAKFIEQGGGDLIIIYNSGRFRMAGRGSLAGLMPYGNANDVVLEMANEVLPVVKRTPVLAGVCATDPFRDIDRFLKQLKDIGFAGIQNFPTVGLIDGQFRQNLEETGMGYDAEVELVQKARALDLITTPYVFNVEEAKKMSEAGADIIVAHMGLTTSGSIGATSGKSLEDCVKLIQEIRDEAIKANPDVIVLCHGGPIAAPEDAEYVISRTKGVHGFYGASSMERLPVEEAITNITKTFKNLKPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CSP7</accession>
    <name>A0A177CSP7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_1084921</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG09998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040363.1">
        <property type="nucleotide sequence ID" value="XM_018174072.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CSP7"/>
    <dbReference type="STRING" id="1460663.A0A177CSP7"/>
    <dbReference type="GeneID" id="28757558"/>
    <dbReference type="InParanoid" id="A0A177CSP7"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF283">
        <property type="entry name" value="RETINOL DEHYDROGENASE 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAG09998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="359" mass="39293" checksum="8540B60D0419B5B5" modified="2016-09-07" version="1">MPSTTYAEFGHDTEALEVAKAFTDGIRGKTIIVTGANSGGIGYTTLQAFASQSPAHLVLASRTSSKIQETIEKLKTEYPEVDYRPLVLNLSSQKAVRDAAAEILSWKDVDAIDIIVNSAGLMGLPERQLTPEGIEMHFGTNHIGHFLLTSLLMPKLITAAQRSPRGATRIVNVSSLSPTVAGVRWSDINFDKINKDLPEEERPNEQILSRWGFSDVMEKSYIPIEGYNQSKAANVLFSIGLSDRLYQKHGIVSIAVHPGIIPTELGRDFGTEMEQAVSNMSKRGAFKYKSLGAGSSTSLTAALDPKLGEGVGEEKDGKVYGVYMIDCQISEMAYIRACSKKEAERLWELSERLVGEKFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CST2</accession>
    <name>A0A177CST2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1237447</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040958.1">
        <property type="nucleotide sequence ID" value="XM_018183897.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CST2"/>
    <dbReference type="GeneID" id="28767383"/>
    <dbReference type="InParanoid" id="A0A177CST2"/>
    <dbReference type="OrthoDB" id="3793888at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG10593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="300" mass="33482" checksum="513F2F3DF37912E8" modified="2016-09-07" version="1">MCQIEGKVATYERNGEFVATSKSLAVATPAPPLHHLQTATPLPSLLHYVDNDLLRRRAEYDRPPNGQAICSACGKHEFAATIKSTYLPLTCGCWMHYRCFIGNVAYQKPHLRRHPKDCCPACGTQLFIWEGIVALTLAERTNVLMPDVKFTPHEAYADANTGMYVVSDKTQYESDCALISALIQSHFLALFEPAAPESRFADGSPDLTACYYAVLADLDYYGCPRSKWLAFSREKKQDGEVSVGFLLFGMLVALKMRGFLNVYHAAVVETEGWAEFENIREGVQRRILADVRGEGWSWGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CTB8</accession>
    <name>A0A177CTB8_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mediator of RNA polymerase II transcription subunit 12</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Mediator complex subunit 12</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CC84DRAFT_484399</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the SRB8-11 complex, which itself associates with the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Mediator complex subunit 12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040806.1">
        <property type="nucleotide sequence ID" value="XM_018186460.1"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CTB8"/>
    <dbReference type="GeneID" id="28769946"/>
    <dbReference type="InParanoid" id="A0A177CTB8"/>
    <dbReference type="OrthoDB" id="20828at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057344">
        <property type="entry name" value="ARM_SRB8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019035">
        <property type="entry name" value="Mediator_Med12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001024">
        <property type="entry name" value="PLAT/LH2_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46567">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46567:SF1">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25326">
        <property type="entry name" value="ARM_SRB8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09497">
        <property type="entry name" value="Med12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01281">
        <property type="entry name" value="Med12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50095">
        <property type="entry name" value="PLAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0010">Activator</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0678">Repressor</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="PLAT" evidence="14">
        <location>
            <begin position="1536"/>
            <end position="1567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1404"/>
            <end position="1530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="89"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1404"/>
            <end position="1419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1420"/>
            <end position="1436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1444"/>
            <end position="1458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1459"/>
            <end position="1479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1480"/>
            <end position="1495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1496"/>
            <end position="1513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00032010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OAG10441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="1567" mass="174364" checksum="D9A02A3833C8EF1E" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CU14</accession>
    <name>A0A177CU14_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Arad-like aldolase/epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1184431</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040745.1">
        <property type="nucleotide sequence ID" value="XM_018180747.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CU14"/>
    <dbReference type="STRING" id="1460663.A0A177CU14"/>
    <dbReference type="GeneID" id="28764233"/>
    <dbReference type="InParanoid" id="A0A177CU14"/>
    <dbReference type="OrthoDB" id="2932980at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.225.10">
        <property type="entry name" value="Class II aldolase/adducin N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051017">
        <property type="entry name" value="Aldolase-II_Adducin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001303">
        <property type="entry name" value="Aldolase_II/adducin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036409">
        <property type="entry name" value="Aldolase_II/adducin_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10672">
        <property type="entry name" value="ADDUCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10672:SF41">
        <property type="entry name" value="CLASS II ALDOLASE_ADDUCIN DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_3G01330)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00596">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01007">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53639">
        <property type="entry name" value="AraD/HMP-PK domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Class II aldolase/adducin N-terminal" evidence="1">
        <location>
            <begin position="19"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG10380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="321" mass="35123" checksum="1F568B0D29D66563" modified="2016-09-07" version="1">MSAGYFPKREKVGLEDLFKGLVTASHILHYHGVLDAYGHVSVRSPDNPATFWMPCNMPPALVSTPEDLVEYKVEDASEVEKDAKKGYLERHIHSEIYKRFPSVNAVVHSHCSAVLPYCISGVPLKASIHMAGFLGSNVPVWDIASHYSSGAKHDLLVRDSQLGASLSAAFKPATSAGFLYSKVRSALPTQIGGSQEPDKEPNFATVLMQSHGFTTLAHGIEEVVYQAIYTKEAAQAQTTALTIRNAHFGHTIEGNVDVQGGGKIKSAKVKAEGDLTYLSDREAHDAWESNQGTVHRPWSLWCREVEVCPLYKNDCPGCEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CU27</accession>
    <name>A0A177CU27_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_502368</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG11023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041388.1">
        <property type="nucleotide sequence ID" value="XM_018186565.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CU27"/>
    <dbReference type="GeneID" id="28770051"/>
    <dbReference type="InParanoid" id="A0A177CU27"/>
    <dbReference type="OrthoDB" id="3945961at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF73">
        <property type="entry name" value="HET DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_8G01020)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG11023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="596" mass="67850" checksum="E68654CADF7F12DC" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CU98</accession>
    <name>A0A177CU98_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">WD40 repeat-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1213898</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040953.1">
        <property type="nucleotide sequence ID" value="XM_018182585.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CU98"/>
    <dbReference type="STRING" id="1460663.A0A177CU98"/>
    <dbReference type="GeneID" id="28766071"/>
    <dbReference type="InParanoid" id="A0A177CU98"/>
    <dbReference type="OrthoDB" id="5362656at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG10588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="282" mass="30949" checksum="1E02BA23F5F91F76" modified="2016-09-07" version="1">MTHADQLPASFSLFIATPRAIYAHSGAFRKRTLFECTSDGIVNARAAKDNSSLLAVADSQLVILHDPARRGDRKYALKSYEGEPRLLVFSPDSRTLYFTTTLSTSIQAYCIPTGELLPPPQIHPSPPTILSISSDGNILLSASSAPPKIYLQDLRFGGSASVSFQPADARSSAVFATFQRYEGRNPSYTSFFLGFQDGTLSLYRLVLPTRRHSYQGVYLNQTQAFLLQPTRLGCIKKLHKPAMGGVTAAEFIPGYKARAISVGHDGRCRLVDFKGRGRVLRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CUB2</accession>
    <name>A0A177CUB2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1081913</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041166.1">
        <property type="nucleotide sequence ID" value="XM_018173955.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CUB2"/>
    <dbReference type="FunCoup" id="A0A177CUB2">
        <property type="interactions" value="75"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CUB2"/>
    <dbReference type="GeneID" id="28757441"/>
    <dbReference type="InParanoid" id="A0A177CUB2"/>
    <dbReference type="OrthoDB" id="269872at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050320">
        <property type="entry name" value="N5-glutamine_MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18895">
        <property type="entry name" value="HEMK METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18895:SF74">
        <property type="entry name" value="MTRF1L RELEASE FACTOR GLUTAMINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="421"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="421"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG10801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="455" mass="50284" checksum="5910025D88FD1140" modified="2016-09-07" version="1">MPRISTSALRKAYAVDALLPRLLPPCRDLRAAQNELRWLREHADHVADARRAQGDTVSKSALLRDLVKQRASGKPLQYLLGTEFFGDLEIRCRPGVLIPRQDTAASVQHLARLVRKAQNLPSELRVLDLCTGTGCIPLLFHHELYAARADVELRALGIDISGKALQLAGHNHSRLRGDKTLADKGSIHYMQADVLANPFADATRGRGRIAVSTALRHARLPHIWDILISNPPYISPSGYWKTTTRSVRGFEPKLALVPPPTAGNSGIAQGDRFYPPILDIASEVEAKIVLLEVADLGQALRVARAAQALRMFDGIEIWREQPNEPDSPSSEVAGFRVLGEGNARSVICWRGTGAAWLGKSERAPAYEDVAFPDVSHRARFRTGPVSVVHQGEALRPYWVKHLNEEQKAVKHNVWRDMETNAARERGHSGAPEKQELDTTVAHAEVLPKVPKKRGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CUR6</accession>
    <name>A0A177CUR6_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Lytic polysaccharide monooxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1161434</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040864.1">
        <property type="nucleotide sequence ID" value="XM_018177736.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CUR6"/>
    <dbReference type="STRING" id="1460663.A0A177CUR6"/>
    <dbReference type="GeneID" id="28761222"/>
    <dbReference type="InParanoid" id="A0A177CUR6"/>
    <dbReference type="OrthoDB" id="2342176at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36182:SF2">
        <property type="entry name" value="LYTIC POLYSACCHARIDE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36182">
        <property type="entry name" value="PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G10930)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008058607" description="Lytic polysaccharide monooxygenase" evidence="2">
        <location>
            <begin position="20"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="276"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="224"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="276"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="297"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG10499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="366" mass="36808" checksum="4A08DB87CB8963BE" modified="2016-09-07" version="1">MSFRSALFAASAFIAATNAHITISNPVPYSADQVKIDKAAITADQFPCKSQYGFKVTQMNSMKVGESQKLEFDGSAVHGGGSCQLSYTTDTEPTKDSVFKVIKSIEGGCPGVDGTKSFEYTLPESIPNGKGTFAWSWFAKMSGAPEFYMNCAPIDVTGGASDASGLDALPDMFIANIASTTCTSPLNHAVKFPNPGENLEDGGTNDVEDPTGDCGAKGTTPVTPSSGAPVESSPAESAPASAPVESAPAASATGAPIQSTLATIATSAPAASAPVASSPVSATIPSSTAPANPGSGSETGGSTGSGSAGTCSSEGAIVCNGANQFGICNGGSVVWQAVAPGTTCSNGNIQKRSMYYGRPALHARRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CUW9</accession>
    <name>A0A177CUW9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_491936</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041067.1">
        <property type="nucleotide sequence ID" value="XM_018186503.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CUW9"/>
    <dbReference type="GeneID" id="28769989"/>
    <dbReference type="InParanoid" id="A0A177CUW9"/>
    <dbReference type="OrthoDB" id="3796623at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG10702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="220" mass="26853" checksum="37F25ABD685A8CEF" modified="2016-09-07" version="1">MFSYHSTRTRERSPLFDDHDDDYYSARRLVRTNSKRAYDDDDDEFDDYPYTNNHKNKPSRALTIRQPSQLEKYNVWSRPASSSPKHTSSKYYRSSFDNDEDDDRTVRYKYTTTRYSPAHTHTHTRSDDDSDREREFRLKVKATFGRPKSSHSSERKAMAWSGDMFRTREKWVDEDWETRERERRRDSLFDDERVGEKSVRFRRVKRTKTEEWRPLNGFRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CV88</accession>
    <name>A0A177CV88_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1132694</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG11156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041521.1">
        <property type="nucleotide sequence ID" value="XM_018175942.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CV88"/>
    <dbReference type="STRING" id="1460663.A0A177CV88"/>
    <dbReference type="GeneID" id="28759428"/>
    <dbReference type="InParanoid" id="A0A177CV88"/>
    <dbReference type="OrthoDB" id="10039976at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053144">
        <property type="entry name" value="Acetyltransferase_Butenolide"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43233">
        <property type="entry name" value="FAMILY N-ACETYLTRANSFERASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G03350)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43233:SF1">
        <property type="entry name" value="FAMILY N-ACETYLTRANSFERASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G03350)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="30"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG11156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="192" mass="21398" checksum="35B578D42F3348FC" modified="2016-09-07" version="1">MTTTKQRTSHRTWTKDSYFISTDPALVPIAELNAVFASDLFYWADALPEDVMRETLNNSLCFGMYESSPANSNTLPIGLLETGTTESKLIGFARCITDSTTFLYLTDVYVDPGMQGKGLGAWLIKCVQEVIEEMPHLRRSLLFTSSWEKSVPFYEKLMGMSVLECQKPAEGEKGSGVAIMQMRGPAFPDALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CVM9</accession>
    <name>A0A177CVM9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein EFR3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1161735</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EFR3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041285.1">
        <property type="nucleotide sequence ID" value="XM_018177823.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CVM9"/>
    <dbReference type="STRING" id="1460663.A0A177CVM9"/>
    <dbReference type="GeneID" id="28761309"/>
    <dbReference type="InParanoid" id="A0A177CVM9"/>
    <dbReference type="OrthoDB" id="19232at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072659">
        <property type="term" value="P:protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039786">
        <property type="entry name" value="EFR3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049150">
        <property type="entry name" value="EFR3_HEAT-like_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47766">
        <property type="entry name" value="PROTEIN EFR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47766:SF1">
        <property type="entry name" value="PROTEIN EFR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21072">
        <property type="entry name" value="EFR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="223"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="795"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="878"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="997"/>
            <end position="1149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="223"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="811"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="885"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="928"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="954"/>
            <end position="963"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG10920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1149" mass="124736" checksum="610DC08E8B317434" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CWA3</accession>
    <name>A0A177CWA3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">High-affinity amino acid transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CC84DRAFT_1140113</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG11097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041462.1">
        <property type="nucleotide sequence ID" value="XM_018176272.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CWA3"/>
    <dbReference type="STRING" id="1460663.A0A177CWA3"/>
    <dbReference type="GeneID" id="28759758"/>
    <dbReference type="InParanoid" id="A0A177CWA3"/>
    <dbReference type="OrthoDB" id="3900342at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000017">
        <property type="entry name" value="Amino acid permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF1">
        <property type="entry name" value="GENERAL AMINO-ACID PERMEASE GAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="87"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="141"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="171"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="197"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="289"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="328"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="390"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="414"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="460"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="495"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="9">
        <location>
            <begin position="59"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAG11097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="586" mass="64073" checksum="E667E9A1D0352704" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CWH3</accession>
    <name>A0A177CWH3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">GPI-anchor transamidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CC84DRAFT_1077937</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C13 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG11863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042228.1">
        <property type="nucleotide sequence ID" value="XM_018173780.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CWH3"/>
    <dbReference type="FunCoup" id="A0A177CWH3">
        <property type="interactions" value="675"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CWH3"/>
    <dbReference type="GeneID" id="28757266"/>
    <dbReference type="InParanoid" id="A0A177CWH3"/>
    <dbReference type="OrthoDB" id="192611at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042765">
        <property type="term" value="C:GPI-anchor transamidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003923">
        <property type="term" value="F:GPI-anchor transamidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016255">
        <property type="term" value="P:attachment of GPI anchor to protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1460:FF:000003">
        <property type="entry name" value="GPI-anchor transamidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028361">
        <property type="entry name" value="GPI_transamidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001096">
        <property type="entry name" value="Peptidase_C13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48067">
        <property type="entry name" value="GPI-ANCHOR TRANSAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48067:SF1">
        <property type="entry name" value="GPI-ANCHOR TRANSAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01650">
        <property type="entry name" value="Peptidase_C13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500138">
        <property type="entry name" value="GPI8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019663">
        <property type="entry name" value="Legumain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00776">
        <property type="entry name" value="HEMOGLOBNASE"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027620448" description="GPI-anchor transamidase" evidence="6">
        <location>
            <begin position="19"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="142"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR019663-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAG11863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="390" mass="44121" checksum="5EE266D22DC350F0" modified="2016-09-07" version="1">MKLSAALAPLLLAPLAAAEHTSNWAVLVGTSRFWFNYRHLANVLSLYRTVKRLGIPDSQIILMLPDDMACNPRNAFPGTVYNNADRALDLYGDNIEVDYRGYEVTVENFIRLMTDRVSEDMPRSKRLMTDERSNILVYMTGHGGNEFLKFQDAEEISAYDLADAFGQMWEKKRYHEMLFMIDTCQANTMYSKFYSPNILATGSSEIDQSSYSHHADNDVGVAVIDRYTYYNLEFLERNVRDPTSKVTMGELFDSYNPADMHSDPGIRYDLFAGGEAGARSRLIMDFFGNVQNVEIDAVSQKNETQWREELEAIDRMILEAKRKHNETLKLRPQAQHIIEEAVAMEQQQSTKKPGAVKVDAESGWSKQIVGAAALLGFASAWAAGSWLESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CWN5</accession>
    <name>A0A177CWN5_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">3-hydroxyisobutyrate dehydrogenase</fullName>
            <ecNumber evidence="3">1.1.1.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CC84DRAFT_1079008</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>3-hydroxy-2-methylpropanoate + NAD(+) = 2-methyl-3-oxopropanoate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17681"/>
            <dbReference type="ChEBI" id="CHEBI:11805"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57700"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.31"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid degradation; L-valine degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HIBADH-related family. 3-hydroxyisobutyrate dehydrogenase subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.31" evidence="3"/>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG11636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042001.1">
        <property type="nucleotide sequence ID" value="XM_018173820.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CWN5"/>
    <dbReference type="STRING" id="1460663.A0A177CWN5"/>
    <dbReference type="GeneID" id="28757306"/>
    <dbReference type="InParanoid" id="A0A177CWN5"/>
    <dbReference type="OrthoDB" id="21615at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008442">
        <property type="term" value="F:3-hydroxyisobutyrate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006574">
        <property type="term" value="P:L-valine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000056">
        <property type="entry name" value="3-hydroxyisobutyrate dehydrogenase a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002204">
        <property type="entry name" value="3-OH-isobutyrate_DH-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029154">
        <property type="entry name" value="HIBADH-like_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015815">
        <property type="entry name" value="HIBADH-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22981:SF7">
        <property type="entry name" value="3-HYDROXYISOBUTYRATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22981">
        <property type="entry name" value="3-HYDROXYISOBUTYRATE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14833">
        <property type="entry name" value="NAD_binding_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000103">
        <property type="entry name" value="HIBADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00895">
        <property type="entry name" value="3_HYDROXYISOBUT_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0101">Branched-chain amino acid catabolism</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6-phosphogluconate dehydrogenase NADP-binding" evidence="9">
        <location>
            <begin position="7"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="3-hydroxyisobutyrate dehydrogenase-like NAD-binding" evidence="10">
        <location>
            <begin position="192"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000103-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF14833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OAG11636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="326" mass="34429" checksum="ECD53C1D77F73831" modified="2016-09-07" version="1">MSPPEKTVAFIGLGVMGYPMAINLRKGLSSDYTLLVCDVVPSALEQFHSETSNHGRVETIQNGFDAIQRANTVITMLPGSAAVKDVYLNPSTGVIAGAEKALQSGGPSKIIMECGTIETSTILEVAKRAKESSVASNLTFVDAPVSGGPMGAQDGTLTFMVGTDNKDVFPTVKSYLSHMGKADAVFLCGDVGAGTAFKVINNYLSAITSLAASEALNIGAKMNLDLALLTDVINVSGGQCWVTSKSNPVPGIQANVPSSRDYEGGFRIELCAKVLKMGSDLADMVGARTILDKPTLEAFGEAMGDERYKGKDARVVYKWLNESEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CWT5</accession>
    <name>A0A177CWT5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1170132</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG11189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041554.1">
        <property type="nucleotide sequence ID" value="XM_018179835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CWT5"/>
    <dbReference type="GeneID" id="28763321"/>
    <dbReference type="InParanoid" id="A0A177CWT5"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG11189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="198" mass="21741" checksum="25495D5013A6B8EF" modified="2016-09-07" version="1">MANRPDLNQSYEAEFKPACVLLTKENILFFYPASGGAFTVGDEPYKWVPEGVPPSAAPHTAQVSHTAASNSRPSRMKQEEVAPKNVFQQHGGEETNALSGRDVARLDTLASPNDAFGLGMEKNVSVVSTKVDSSYSDLCKENAWPCRKKRLPFISPGLWHASPLTQFWVYKLLRKPSLGEVQPNSDSAPRNTPNKPIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CXC6</accession>
    <name>A0A177CXC6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">EF-hand</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CC84DRAFT_55686</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG11851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042216.1">
        <property type="nucleotide sequence ID" value="XM_018186681.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CXC6"/>
    <dbReference type="FunCoup" id="A0A177CXC6">
        <property type="interactions" value="820"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CXC6"/>
    <dbReference type="GeneID" id="28770167"/>
    <dbReference type="InParanoid" id="A0A177CXC6"/>
    <dbReference type="OrthoDB" id="343296at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000172">
        <property type="entry name" value="Cell division control protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050145">
        <property type="entry name" value="Centrin_CML-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23050">
        <property type="entry name" value="CALCIUM BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00036">
        <property type="entry name" value="EF-hand_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="78"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="171"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="207"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAG11851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="238" mass="26375" checksum="E6B02D7120D16172" modified="2016-09-07" version="1">MATSSNNQPRFGHGGGINARAAPLPTHQQPYTTPGFGPSSKNAQTREAERLDAQRRAREQKAAAETDAQTALESLSEEQREEIQEAFNLFDLDKDGYIDYHELKVAMKALGFDEPKQEILGILQTNGVQAAGQASGSKQKQPVGNYQSPPRWLLPFQSFQVIMAQRIVSRNPQDEINRAFDLFDGDGKGNITLQDLERVAKELGEGLQHEELQAMIDEFDMNGDGAISREEFINICLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CXQ0</accession>
    <name>A0A177CXQ0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycogen debranching enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1134195</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG11981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042346.1">
        <property type="nucleotide sequence ID" value="XM_018176012.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CXQ0"/>
    <dbReference type="STRING" id="1460663.A0A177CXQ0"/>
    <dbReference type="GeneID" id="28759498"/>
    <dbReference type="InParanoid" id="A0A177CXQ0"/>
    <dbReference type="OrthoDB" id="2591256at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008058724" evidence="1">
        <location>
            <begin position="21"/>
            <end position="714"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG11981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="714" mass="77647" checksum="A0BA02C7B4FABFFD" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CY55</accession>
    <name>A0A177CY55_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_1226864</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042869.1">
        <property type="nucleotide sequence ID" value="XM_018183599.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CY55"/>
    <dbReference type="STRING" id="1460663.A0A177CY55"/>
    <dbReference type="GeneID" id="28767085"/>
    <dbReference type="InParanoid" id="A0A177CY55"/>
    <dbReference type="OrthoDB" id="5329176at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF156">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="102"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="132"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="181"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="211"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="53"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAG12504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="360" mass="39836" checksum="94C45768D0B40DCA" modified="2016-09-07" version="1">MPLVARASPKSSRGEELVNLAIAFIVIQTIVLILFYISRYAKVKHISGVEMKYFMPLGYMFCIGNAVCAILMVRLGGMGRHVLTLNAEEILMLGKVFKAEEMIYLASVMFPKLAALSLYIRLFMNPVRRLSYIVGAFVVCSFLAGWLTWAFSCRPFAFNWNKTIPGGHCINTNMSYTYFSIPNLLSDLALILLPLHPLWKLNVARSQRIGLLVTFVLGGFGIVTAIIRFVSFITTDIRSDPSFHGATTMRWGIIEPAMYQMAATLPTLRPLLTSSMSVLSRLSSKSKLESSNGGTDAGAEIASGDRNHFVKLDDYHYLQDSRTSKGLGKKYSGVLKTTNVSVTSHTTLSADEYVMGPARP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CYC6</accession>
    <name>A0A177CYC6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1170578</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG11719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042084.1">
        <property type="nucleotide sequence ID" value="XM_018179862.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CYC6"/>
    <dbReference type="GeneID" id="28763348"/>
    <dbReference type="InParanoid" id="A0A177CYC6"/>
    <dbReference type="OrthoDB" id="3778648at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG11719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="219" mass="24813" checksum="6D5CB39992117264" modified="2016-09-07" version="1">MASMRRSRLSAHNLRIHTAAFPKVGIPNIVTEMILTLITQQPYFPINRIREEMSRPDDEANDDRTPLDHLGFSFDGLSPQDIDMEVRRQASMDALGLYSGNVASLSTPMDRLIARQDRRGPEEMHARTRDVETLDASELASELSEDARADDVVSVGSFLASSDTLSVSREHFVESAREQKEQAKRSWRRLKMRRRNTTDKMKSTRRPHQAAPAVQAPRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CYI1</accession>
    <name>A0A177CYI1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Zf-UBP-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CC84DRAFT_1159582</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042606.1">
        <property type="nucleotide sequence ID" value="XM_018177277.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CYI1"/>
    <dbReference type="FunCoup" id="A0A177CYI1">
        <property type="interactions" value="738"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CYI1"/>
    <dbReference type="GeneID" id="28760763"/>
    <dbReference type="InParanoid" id="A0A177CYI1"/>
    <dbReference type="OrthoDB" id="273556at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16457">
        <property type="entry name" value="RING-H2_BRAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12717">
        <property type="entry name" value="RRM_ETP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011422">
        <property type="entry name" value="BRAP2/ETP1_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034931">
        <property type="entry name" value="ETP1_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047243">
        <property type="entry name" value="RING-H2_BRAP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001607">
        <property type="entry name" value="Znf_UBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24007">
        <property type="entry name" value="BRCA1-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24007:SF7">
        <property type="entry name" value="BRCA1-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07576">
        <property type="entry name" value="BRAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02148">
        <property type="entry name" value="zf-UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00290">
        <property type="entry name" value="ZnF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50271">
        <property type="entry name" value="ZF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="7">
        <location>
            <begin position="353"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="UBP-type" evidence="8">
        <location>
            <begin position="386"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="16"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="292"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="673"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="610"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAG12241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="704" mass="77537" checksum="B7D4D1052BC69835" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CZ45</accession>
    <name>A0A177CZ45_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">rRNA methyltransferase 1, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CC84DRAFT_1108304</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042542.1">
        <property type="nucleotide sequence ID" value="XM_018175198.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CZ45"/>
    <dbReference type="FunCoup" id="A0A177CZ45">
        <property type="interactions" value="220"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CZ45"/>
    <dbReference type="GeneID" id="28758684"/>
    <dbReference type="InParanoid" id="A0A177CZ45"/>
    <dbReference type="OrthoDB" id="270651at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016435">
        <property type="term" value="F:rRNA (guanine) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18105">
        <property type="entry name" value="SpoU-like_MRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047182">
        <property type="entry name" value="MRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047261">
        <property type="entry name" value="MRM1_MeTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001537">
        <property type="entry name" value="SpoU_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013123">
        <property type="entry name" value="SpoU_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46103">
        <property type="entry name" value="RRNA METHYLTRANSFERASE 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46103:SF1">
        <property type="entry name" value="RRNA METHYLTRANSFERASE 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00588">
        <property type="entry name" value="SpoU_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08032">
        <property type="entry name" value="SpoU_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00967">
        <property type="entry name" value="SpoU_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="alpha/beta knot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="RNA 2-O ribose methyltransferase substrate binding" evidence="11">
        <location>
            <begin position="145"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="37"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="95"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="37"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="114"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OAG12177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="465" mass="50494" checksum="45589CBC51A6754D" modified="2016-09-07" version="1">MLQSGPLRPTVLRIPRFTCLGTRSEGRNKSITAAIERGRSSGDRELEFSSGRDRRGDRRRFQAEVATGPERRGSKNLFHGQKRLDIGSSRFAGAARGSYRDATGSPRTTTSADAADHQERYEDSARRRGAARIESLPYTTAASEFIYGYSSVLAAIKANRRKLHKLYIHARGASHVGLTALVARAKKKVDIREVGDEYLQAFDKASSGRPHNGFILEASPLPVPPLISLVSSNINLGQFEVALDSQSREDLEINGKQTEFTYNSAGWRHPLVLYADGVLDEGNLGAIARSAYFLGVDAIVTPTRQSAPWSHIALKASAGAAEAIPIFKVNQGTDFLGRSARAGWRIYASDAVPPLELPALQGALSSIKPSPPSTEVIYTGARSTKRLPVEHCPVESHPTILMMGAEGTGLRTSLLNLAHYKVGIRHGRNVDEIGVDSLNVSVAASLLCYDMLQKPKPRAPGNMLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CZB4</accession>
    <name>A0A177CZB4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CIA30-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_1160129</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CIA30 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018043240.1">
        <property type="nucleotide sequence ID" value="XM_018177418.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CZB4"/>
    <dbReference type="STRING" id="1460663.A0A177CZB4"/>
    <dbReference type="GeneID" id="28760904"/>
    <dbReference type="InParanoid" id="A0A177CZB4"/>
    <dbReference type="OrthoDB" id="426386at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010257">
        <property type="term" value="P:NADH dehydrogenase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013857">
        <property type="entry name" value="NADH-UbQ_OxRdtase-assoc_prot30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039131">
        <property type="entry name" value="NDUFAF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13194">
        <property type="entry name" value="COMPLEX I INTERMEDIATE-ASSOCIATED PROTEIN 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13194:SF19">
        <property type="entry name" value="NAD(P)-BINDING ROSSMANN-FOLD SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08547">
        <property type="entry name" value="CIA30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="212"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="NADH:ubiquinone oxidoreductase intermediate-associated protein 30" evidence="3">
        <location>
            <begin position="17"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAG12875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="244" mass="27388" checksum="E2B0D470CFCD21BA" modified="2016-09-07" version="1">MVKDKEHVLFGGDKTWKASDWTASDDRVRGGKSQSYLEISGTTARFHGHLDIETLGGAGFASQRTVAEDCTWDVSHYDGILLNLGKSDGKRYTFIMKDELLPQNPDNGREQATISWEYDFVVSVNAAQAESSFVYIPWKDLKPTYRGKEKKGVKDFDTKNVKRFSLMMRSFFGDQHGDFSLSVKSIKAVSRSKDLEKGPTESGKTATLRAPLLMSLLAAGILVYGLCAYVCPWVMNTHTRHWGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CZR1</accession>
    <name>A0A177CZR1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CC84DRAFT_115086</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042757.1">
        <property type="nucleotide sequence ID" value="XM_018176719.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CZR1"/>
    <dbReference type="STRING" id="1460663.A0A177CZR1"/>
    <dbReference type="GeneID" id="28760205"/>
    <dbReference type="InParanoid" id="A0A177CZR1"/>
    <dbReference type="OrthoDB" id="3862662at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF20">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="19"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAG12392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="326" mass="36329" checksum="55A0FB1442290771" modified="2016-09-07" version="1">MNGTNGFNHGSPQPLAQRTCSQCKSSKKKCDKVLPKCGRCLRLSIDCLYPDLEKTHESETGNEANDSRFDEVFERLRRIEAQVFSPQSAAQNGTDSQRSLIELAVSHGVESPNPTNWTLEPGTLKPQYMSLILWQSILATLDEHKATIHGIMRVYITQTDQWLPMVSNRKWQKELALFGTLLSSDRFVLLALAMHLVVSPPADHPPAASLAESPWYRKCKYLFQYYVGFKEPNIEMVQAGMLIALFEFNQDIQDRALTTLGTCARLAYLLDFDEVMAKHAARNLGISTCPQKSCQKPNACPFISTTAPHAIVPAPTKGHPSPTSPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177D022</accession>
    <name>A0A177D022_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Obg-like ATPase 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CC84DRAFT_1255191</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Hydrolyzes ATP, and can also hydrolyze GTP with lower efficiency. Has lower affinity for GTP.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG13063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018043428.1">
        <property type="nucleotide sequence ID" value="XM_018184514.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177D022"/>
    <dbReference type="FunCoup" id="A0A177D022">
        <property type="interactions" value="972"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177D022"/>
    <dbReference type="GeneID" id="28768000"/>
    <dbReference type="InParanoid" id="A0A177D022"/>
    <dbReference type="OrthoDB" id="424823at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04867">
        <property type="entry name" value="TGS_YchF_OLA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01900">
        <property type="entry name" value="YchF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.300:FF:000001">
        <property type="entry name" value="Ribosome-binding ATPase YchF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.30:FF:000001">
        <property type="entry name" value="Ribosome-binding ATPase YchF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.300">
        <property type="entry name" value="TGS-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00944">
        <property type="entry name" value="YchF_OLA1_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004396">
        <property type="entry name" value="ATPase_YchF/OLA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023192">
        <property type="entry name" value="TGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013029">
        <property type="entry name" value="YchF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041706">
        <property type="entry name" value="YchF_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00092">
        <property type="entry name" value="redox-regulated ATPase YchF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23305">
        <property type="entry name" value="OBG GTPASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23305:SF11">
        <property type="entry name" value="OBG-LIKE ATPASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06071">
        <property type="entry name" value="YchF-GTPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006641">
        <property type="entry name" value="CHP00092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="TGS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OBG-type G" evidence="4">
        <location>
            <begin position="21"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="TGS" evidence="5">
        <location>
            <begin position="305"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="30"/>
            <end position="35"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAG13063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="393" mass="43456" checksum="105DB1637D6061E1" modified="2016-09-07" version="1">MPPKKNVVEEKVLLGRPGNSLKSGIVGLANVGKSTLFQAITKCHLGNPANFPYATIDPEEARVIVPDERFDWLVEHYKPKSVVPANLTVYDIAGLTKGASTGAGLGNAFLSHIRAVDAIFQVVRCFDDAEIIHVEGDVDPVRDLNIISEELRLKDIEFVEKSLEKLVKETRRGGQSLEMKKLKEEQATVEEVLQMLKDGIDVRRKNWSPKQVEHINPLFLLSAKPVVYLVNLSEKDYIRQKNKNLPKIAQWVKENTNGDPVIPVSVSLEERLGAMTEEEAAKECEAIGTKSALPKIVVTMRKALNLGSFFTTGTDEVRQWTLRNGTKAPQAAGVIHGDFEKTFIQAVVYNYKVLREEGDEASVKAKGKIMTKGKDYVVEDGDILLIKAGAAKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177D234</accession>
    <name>A0A177D234_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Eukaryotic translation initiation factor 3 subunit H</fullName>
            <shortName evidence="4">eIF3h</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CC84DRAFT_1160328</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the eIF-3 subunit H family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG13109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018043474.1">
        <property type="nucleotide sequence ID" value="XM_018177474.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177D234"/>
    <dbReference type="STRING" id="1460663.A0A177D234"/>
    <dbReference type="GeneID" id="28760960"/>
    <dbReference type="InParanoid" id="A0A177D234"/>
    <dbReference type="OrthoDB" id="10265695at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd08065">
        <property type="entry name" value="MPN_eIF3h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000052">
        <property type="entry name" value="Eukaryotic translation initiation factor 3 subunit H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03007">
        <property type="entry name" value="eIF3h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027524">
        <property type="entry name" value="eIF3h"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045810">
        <property type="entry name" value="eIF3h_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050242">
        <property type="entry name" value="JAMM_MPN+_peptidase_M67A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10410">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19445">
        <property type="entry name" value="eIF3h_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MPN" evidence="5">
        <location>
            <begin position="13"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAG13109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="370" mass="41514" checksum="E843FC0B31F27D1B" modified="2016-09-07" version="1">MADALKDSPIKAVQVEALVVMKLVNHAAKTFPTVATGSLVGMESLDQPGLLEVTSCFPFPNVDVPASDDHRDNHNHKDLAAAAPRAKANLAYQNEMIKFLREVNVDANNIGWYTSTSMGNFINLNTIENQFFYQKDPNEKAIALVHDVSRSSQGSLSLRAYRLSPAFVAAYKEGKFTTDNLQKSGLRYHDILVEIPVTIHNSHLLTSLLHQLPSDAPKEELSFPPNLAALLQDPNTPEPPFFPNYDSLDLAIDPFLEKTCDLLLESIENHHTELNNHQYYQRSLAREQAKITAWQQKRKAENAARTASKQPLLPEDEWQRLFKLPQEPSRLETLLNSRQVEQYARQVDGFTAGVTTKMFAVKNNLLPGES</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BTC4</accession>
    <name>A0A177BTC4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">TPR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1210728</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441565">
        <property type="protein sequence ID" value="OAF98643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029009.1">
        <property type="nucleotide sequence ID" value="XM_018182311.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BTC4"/>
    <dbReference type="STRING" id="1460663.A0A177BTC4"/>
    <dbReference type="GeneID" id="28765797"/>
    <dbReference type="InParanoid" id="A0A177BTC4"/>
    <dbReference type="OrthoDB" id="10050400at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031942">
        <property type="term" value="C:i-AAA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051787">
        <property type="term" value="F:misfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006515">
        <property type="term" value="P:protein quality control for misfolded or incompletely synthesized proteins"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd24145">
        <property type="entry name" value="Mgr3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040201">
        <property type="entry name" value="Mrg3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28142">
        <property type="entry name" value="MITOCHONDRIAL INNER MEMBRANE I-AAA PROTEASE SUPERCOMPLEX SUBUNIT MGR3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28142:SF1">
        <property type="entry name" value="MITOCHONDRIAL INNER MEMBRANE I-AAA PROTEASE SUPERCOMPLEX SUBUNIT MGR3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="62"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="307"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="314"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAF98643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="421" mass="47549" checksum="034AC1293E9439BA" modified="2016-09-07" version="1">MFSRAVPRVASRAAGLAQCEASQVAAGAPSWALRSPQHLSRRYRSTFREQFREQFRRSPISFPFALVSIFALAGWGAYYIPWYYHNVIQKPYHNFPEPVAKKLRRAIFYSRGQHLDIREANKYFRQALQLATEMGMDPFSDEIMGVKYAIAALFEEQGYHAMACDVLEIMRTDTQRWIDEFSDKHITDGNRSRVKKNMVQINLKLGQLYDCPYVNEPQDAEKRLVEAVEGALGELQRRETEGIKQGEGDWMTNDELGATLEALGQHYEHNDSHYLALPLFLRALELCPPTSCHSVVLMNNISTCLAQQTPPPASLTSSSPSSFPNAPAPPRTALVDQARQWADKALQRAGSITDQDEECNVGCAVATHNLGEFYEMEGKIQDARRKYKDAEQLAKKIGFREGQANAKAGIARLKELEKAQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BTY5</accession>
    <name>A0A177BTY5_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_408697</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441563">
        <property type="protein sequence ID" value="OAF98872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029238.1">
        <property type="nucleotide sequence ID" value="XM_018186081.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BTY5"/>
    <dbReference type="GeneID" id="28769567"/>
    <dbReference type="InParanoid" id="A0A177BTY5"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008057317" description="Secreted protein" evidence="1">
        <location>
            <begin position="24"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAF98872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="155" mass="17468" checksum="2EC6F14B6E56FD9F" modified="2016-09-07" version="1">MRSTAFLALLISAPLFPFCPLQALLLNIADDVRQPHPSSSRRRKLEARHQSPIHACARAYAGLVEPLSLLWTGRCYQSLFPPPPFPFEADDCVVLVPLSQSQHSWITSLSFGRWSKGFRQSLRPCPGRSPAWHVHLGRSRTYLTYCQDSTVPLLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BUF3</accession>
    <name>A0A177BUF3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1169653</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441563">
        <property type="protein sequence ID" value="OAF98914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029280.1">
        <property type="nucleotide sequence ID" value="XM_018179714.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BUF3"/>
    <dbReference type="GeneID" id="28763200"/>
    <dbReference type="InParanoid" id="A0A177BUF3"/>
    <dbReference type="OrthoDB" id="10549643at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAF98914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="214" mass="23544" checksum="503914641CE7D22A" modified="2016-09-07" version="1">MRVQCKRRSQIANRCIGGRHLSGDGYAIHPSNVYPNREAAVAFLCHKEWPYSAGEHGISPTKDAKNAHGVSLDLEVLCRAVHSFHFGSLATHFPNTEAPLDYATVIMQAIPKTRHAHSLLCNRVSLTPSVGLSPFQYCSQLQSRSMHQSLIHDMPPHCQYPKAGGSTSCRFANMQELQLDHSHSTRDFLSYSGTVHVESPLDTPSPTCGCHKGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BUR6</accession>
    <name>A0A177BUR6_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">SH3 domain signaling protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CC84DRAFT_1264227</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441562">
        <property type="protein sequence ID" value="OAF99213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029579.1">
        <property type="nucleotide sequence ID" value="XM_018185293.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BUR6"/>
    <dbReference type="STRING" id="1460663.A0A177BUR6"/>
    <dbReference type="GeneID" id="28768779"/>
    <dbReference type="InParanoid" id="A0A177BUR6"/>
    <dbReference type="OrthoDB" id="10255128at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031097">
        <property type="term" value="C:medial cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990528">
        <property type="term" value="C:Rvs161p-Rvs167p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051666">
        <property type="term" value="P:actin cortical patch localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097320">
        <property type="term" value="P:plasma membrane tubulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07599">
        <property type="entry name" value="BAR_Rvs167p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000100">
        <property type="entry name" value="SH3 domain-containing YSC84-like protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004148">
        <property type="entry name" value="BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046982">
        <property type="entry name" value="BIN3/RVS161-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47174">
        <property type="entry name" value="BRIDGING INTEGRATOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47174:SF2">
        <property type="entry name" value="SH3 DOMAIN SIGNALLING PROTEIN (AFU_ORTHOLOGUE AFUA_5G07670)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03114">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01887">
        <property type="entry name" value="SPECTRNALPHA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51021">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="BAR" evidence="5">
        <location>
            <begin position="8"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="438"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="272"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="340"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="372"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="393"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAF99213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="495" mass="55895" checksum="8D1FA67F14FCF564" modified="2016-09-07" version="1">MQRMQRKFGRLPFMARTPNEADIEAMLRDFNDSDQMLKNIEEASAQWRDAWTNILNHQLSCAEGLHSIYKPVAGEFTRHEHADTPAETMERAVKLEEAFAELKTDMMEEIKDIDKKLILPAKIARDSLKPMKKAITKREDRKVDYERYKGRAEALQKKKTRSDRENTALAKHEADLERAIHEYNYADEGLRTQLPKLNAATFSLLPHLLANQIILQNNLIGNLYTVLHQYSHEQGYPDPPPEPEEVIPEWDASFTSMRKEMEENFELLRTGKARTQPMRLPDKGDTITGIGIRNKVLPGRRTSSSETIPIRDRSPRPQRHNLPPTNEDDGPPAPKLNLASKPSMNQLNASKPRIGGASPGLIPTPTFDQFGRRTSSYSDASSTHTNGHDDYFGNSNGNGRPRIPSTSSSYGAGYPSPQALAAKKKPPPPPPPKKVGSFHGEYVTAMYDFEGQSEGDLSFREGDKIRVIKKTNSSQDWWEGELRGYKGSFPANYVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BVA9</accession>
    <name>A0A177BVA9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1223086</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441562">
        <property type="protein sequence ID" value="OAF99413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029779.1">
        <property type="nucleotide sequence ID" value="XM_018183459.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BVA9"/>
    <dbReference type="GeneID" id="28766945"/>
    <dbReference type="InParanoid" id="A0A177BVA9"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12087">
        <property type="entry name" value="TM_EGFR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAF99413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="111" mass="11861" checksum="1A31D19E328FADBF" modified="2016-09-07" version="1">MSTPASPYGSTVSTSAHDHTSTGIIAGSVVGGVIALGIIALLAFVIHKGSKHRGSEIHRQPQVDKMPYQEFDQHDALSDPIVCQGGRHEDISELANVSVYELPKKVTQQSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BVS2</accession>
    <name>A0A177BVS2_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Alpha/beta-hydrolase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_426518</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441564">
        <property type="protein sequence ID" value="OAF98831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029197.1">
        <property type="nucleotide sequence ID" value="XM_018186186.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BVS2"/>
    <dbReference type="GeneID" id="28769672"/>
    <dbReference type="InParanoid" id="A0A177BVS2"/>
    <dbReference type="OrthoDB" id="4540290at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012023266" description="Alpha/beta-hydrolase" evidence="1">
        <location>
            <begin position="16"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAF98831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="374" mass="38760" checksum="D1ACE674AA586236" modified="2016-09-07" version="1">MYGFAFASLVALAACAPQRGGRQRATAQQQAAQIPQGISQATDGSMILDATVNINQLPIRFKIAAPADQFTAASGVPGAAAASGANGTMGVNVLLHGDGGQSFFDFPNQNLQANTMGVALLAPNANLFWGGGSGLDRTDGVAHAQAVSDFVTKAMPQLVAFDAANVKFTGVSGGSLLMSGFFIPAQMQNFANSAVELNCGAMPPQVNFANAAAVMSTLRIHYQSTQSELTLLQDAIPQAVVAYEQLAANAGLGAAQINALQTVDNTPAGGHCEFDGKDFVSGVQTMLTSFSNVVQGGDGVVAGLGAPSNGNVLTGVVGNEKLQFAAGRRKRGVESMVVKRWAEALVPKPRRRRQDVVVEEEGVAMLACDRMRCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BW82</accession>
    <name>A0A177BW82_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">U three protein 23</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CC84DRAFT_1169721</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in rRNA-processing and ribosome biogenesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the UTP23/FCF1 family. UTP23 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV441563">
        <property type="protein sequence ID" value="OAF99001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029367.1">
        <property type="nucleotide sequence ID" value="XM_018179737.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BW82"/>
    <dbReference type="FunCoup" id="A0A177BW82">
        <property type="interactions" value="1016"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177BW82"/>
    <dbReference type="GeneID" id="28763223"/>
    <dbReference type="InParanoid" id="A0A177BW82"/>
    <dbReference type="OrthoDB" id="25675at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09865">
        <property type="entry name" value="PIN_ScUtp23p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000006">
        <property type="entry name" value="rRNA-processing protein UTP23 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006984">
        <property type="entry name" value="Fcf1/UTP23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057776">
        <property type="entry name" value="UTP23_sensor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12416">
        <property type="entry name" value="RRNA-PROCESSING PROTEIN UTP23 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04900">
        <property type="entry name" value="Fcf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24779">
        <property type="entry name" value="UTP23_sensor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="UTP23 sensor motif region" evidence="9">
        <location>
            <begin position="211"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="161"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="162"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="194"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="282"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00076388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF24779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAF99001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="294" mass="33386" checksum="0214DE4028FEDD23" modified="2016-09-07" version="1">MKLKRAKAYRKLMHQYEVTFGFRSPYQVLVDDQILEDCWRGKIQLLERLQGCLQGAIKPMVTQCCMRALYNAKPKNDALIKWAQDNLERRRCNHHELEEPLSALECLSAVIDPKDSKTNKHRYVVASQDRKVRAHLRTIPGVPLIYLERAVMIMEPMNTASEELREREERNKFRLGLKGQRNPDQPPKRKRDDEEQGAEEQNTEEARPQKKKKQKGPKQPNPLSMKKAKKEVPPGSATKPKSTEPKPPRPAAADSTDHPAADGEDAGPRKRKRKHKPKGDGDAAANVDAEAAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BW91</accession>
    <name>A0A177BW91_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Vacuolar protein sorting-associated protein 17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CC84DRAFT_1104271</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the membrane-associated retromer complex which is essential in endosome-to-Golgi retrograde transport.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the retromer complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 6">Belongs to the VPS17 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441562">
        <property type="protein sequence ID" value="OAF99220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029586.1">
        <property type="nucleotide sequence ID" value="XM_018175048.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BW91"/>
    <dbReference type="FunCoup" id="A0A177BW91">
        <property type="interactions" value="53"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177BW91"/>
    <dbReference type="GeneID" id="28758534"/>
    <dbReference type="InParanoid" id="A0A177BW91"/>
    <dbReference type="OrthoDB" id="9976382at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005628">
        <property type="term" value="C:prospore membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030905">
        <property type="term" value="C:retromer, tubulation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140318">
        <property type="term" value="F:protein transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032120">
        <property type="term" value="P:ascospore-type prospore membrane formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd06891">
        <property type="entry name" value="PX_Vps17p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000046">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1520.10:FF:000034">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014461">
        <property type="entry name" value="Retromer_complex_Vps17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053055">
        <property type="entry name" value="VPS17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037907">
        <property type="entry name" value="Vps17_PX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015404">
        <property type="entry name" value="Vps5_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47433">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47433:SF1">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09325">
        <property type="entry name" value="Vps5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF011791">
        <property type="entry name" value="Vps17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PX" evidence="8">
        <location>
            <begin position="159"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="Sorting nexin/Vps5-like C-terminal" evidence="9">
        <location>
            <begin position="289"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="484"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="19"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="60"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="542"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00060860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00073022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR011791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF09325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAF99220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="586" mass="64466" checksum="598DED28A44C949A" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BWI2</accession>
    <name>A0A177BWI2_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CC84DRAFT_1169885</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RBT5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KV441564">
        <property type="protein sequence ID" value="OAF98726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029092.1">
        <property type="nucleotide sequence ID" value="XM_018179780.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BWI2"/>
    <dbReference type="STRING" id="1460663.A0A177BWI2"/>
    <dbReference type="GeneID" id="28763266"/>
    <dbReference type="InParanoid" id="A0A177BWI2"/>
    <dbReference type="OrthoDB" id="3065412at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051735">
        <property type="entry name" value="CFEM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008427">
        <property type="entry name" value="Extracellular_membr_CFEM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37928">
        <property type="entry name" value="CFEM DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G14090)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37928:SF2">
        <property type="entry name" value="GPI ANCHORED CFEM DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G10580)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05730">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00747">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52012">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12 15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="6 15" id="KW-0349">Heme</keyword>
    <keyword evidence="10 15" id="KW-0408">Iron</keyword>
    <keyword evidence="14" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="9 17" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008057396" description="CFEM domain-containing protein" evidence="17">
        <location>
            <begin position="19"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="CFEM" evidence="18">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="105"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="15">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="40"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="49"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS52012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="OAF98726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="170" mass="16494" checksum="3E11F37E5E5FAEEB" modified="2016-09-07" version="1">MRFSNVAILFALSSCAVAQDILGSLPRCGQNCFGNNFQGCQQFDYKCICGNKDLIAELSCCVSKNCNSNDQNTIITLASGLCKAYGVDVPTQASCAASASSTASTASSVSSGSASSAGGSSVTTAPATTSASESQSAAAQTSTGSPGAAGPVATAGAGLGLAVGVLLAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BWS1</accession>
    <name>A0A177BWS1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Sterol-4-alpha-carboxylate 3-dehydrogenase ERG26, decarboxylating</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15 16">C-3 Sterol dehydrogenase ERG26</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13 14">C-4 decarboxylase ERG26</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Sterol-4-alpha-carboxylate 3-dehydrogenase erg26, decarboxylating</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CC84DRAFT_1223260</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="10">Heterotetramer of ERG25, ERG26, ERG27 and ERG28. ERG28 acts as a scaffold to tether ERG27 and other 4,4-demethylation-related enzymes, forming a demethylation enzyme complex, in the endoplasmic reticulum.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the 3-beta-HSD family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441563">
        <property type="protein sequence ID" value="OAF98957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029323.1">
        <property type="nucleotide sequence ID" value="XM_018183476.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BWS1"/>
    <dbReference type="FunCoup" id="A0A177BWS1">
        <property type="interactions" value="398"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177BWS1"/>
    <dbReference type="GeneID" id="28766962"/>
    <dbReference type="InParanoid" id="A0A177BWS1"/>
    <dbReference type="OrthoDB" id="10058185at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000252">
        <property type="term" value="F:3-beta-hydroxysteroid dehydrogenase [NAD(P)+]/C4-decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000346">
        <property type="entry name" value="C-3 sterol dehydrogenase/C-4 decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002225">
        <property type="entry name" value="3Beta_OHSteriod_DH/Estase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051783">
        <property type="entry name" value="NAD(P)-dependent_oxidoreduct"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48079:SF6">
        <property type="entry name" value="NAD(P)-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48079">
        <property type="entry name" value="PROTEIN YEEZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01073">
        <property type="entry name" value="3Beta_HSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="domain" description="Ketoreductase" evidence="18">
        <location>
            <begin position="12"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00046995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00067470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00067985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00081267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00081397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00081452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00082106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="OAF98957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="372" mass="40872" checksum="01415BADBF383906" modified="2016-09-07" version="1">MAAAKAPVPSLGHVLVVGGCGFLGSHIVSLIAKRHPQTRISVLDLRTTANRHASPTVSYHDGDITDLHALEALFAQLRPDAIIHTASPHFHLPPAVHDKVNVEGTKNLLAAAQETGVKAFVYTSSASVILGPETELVNANEDWPMVTGAAQPEHYTSTKAYAETAVLAANRTPASFLTCAIRPAGIFGEGDVQLLPPMLSAFRKGQTKYQVGANDNLFDFTHVENVAYGHLLAVQALLYSHKMLPTVPLDTERVDGEAFFITNGQPVYFWDFARAVWHEAGDRRPLSAVWKLDRDFAMGVGAILENLFWVLGRTPNITRKQVRYSTLSKYHDISKAKRRLGYAPLVQLDEGVRRGVRWQLENEAKAAQKKDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BWT7</accession>
    <name>A0A177BWT7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycosyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CC84DRAFT_1169923</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 15 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441564">
        <property type="protein sequence ID" value="OAF98779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029145.1">
        <property type="nucleotide sequence ID" value="XM_018179790.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BWT7"/>
    <dbReference type="STRING" id="1460663.A0A177BWT7"/>
    <dbReference type="GeneID" id="28763276"/>
    <dbReference type="InParanoid" id="A0A177BWT7"/>
    <dbReference type="OrthoDB" id="439943at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000026">
        <property type="term" value="F:alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000032">
        <property type="term" value="P:cell wall mannoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002685">
        <property type="entry name" value="Glyco_trans_15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31121">
        <property type="entry name" value="ALPHA-1,2 MANNOSYLTRANSFERASE KTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31121:SF2">
        <property type="entry name" value="MANNOSYLTRANSFERASE KTR5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01793">
        <property type="entry name" value="Glyco_transf_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018153">
        <property type="entry name" value="Glyco_trans_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR018153-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAF98779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="423" mass="49231" checksum="9A314ECA00BF63DE" modified="2016-09-07" version="1">MLPRIGSHRWRSTKYQILGVILLGLLLEVLLHQYHYHVPRPSEDLDAVFQVGCAEPDTRAPRENAAIIMLARNEDIESALTSLQSLEDHFNRWFHYPVVFMNNEPFSADFKNRVSDVVSGETVFELLSSDFFGFPSWMDNAQGSELVRANGALGVHKGDMESYHHMCRFYSGKFYDVPALKQYKWYWRVEPHVQFSCAITYDPFRLMRERGKKYGYTIALWELDNTVPELFRAVSEFKAMKRIATSNLWKGFIRPTWMPWGLRWMKAAQPLHDASGDSWNLCHFWSNFEIGDLDFFRSEAHREFFEFLDKKGGFYTERWGDASVHALAAALLLKPEELHHFEDFGYFHDPWVVAPANALGKQLPESEVLGPVGESVVEAEEGGTGCRCERKQIRNFQNWCMNRVQRPVKPEAWPNRMWGDWKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BXI7</accession>
    <name>A0A177BXI7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 10">Chitin synthase</fullName>
            <ecNumber evidence="2 10">2.4.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CC84DRAFT_1168946</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Polymerizes chitin, a structural polymer of the cell wall and septum, by transferring the sugar moiety of UDP-GlcNAc to the non-reducing end of the growing chitin polymer.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>[(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n) + UDP-N-acetyl-alpha-D-glucosamine = [(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16637"/>
            <dbReference type="Rhea" id="RHEA-COMP:9593"/>
            <dbReference type="Rhea" id="RHEA-COMP:9595"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17029"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="EC" id="2.4.1.16"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Cell membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the chitin synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.16" evidence="2 10"/>
    <dbReference type="EMBL" id="KV441560">
        <property type="protein sequence ID" value="OAG00063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030428.1">
        <property type="nucleotide sequence ID" value="XM_018179533.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BXI7"/>
    <dbReference type="FunCoup" id="A0A177BXI7">
        <property type="interactions" value="81"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177BXI7"/>
    <dbReference type="GeneID" id="28763019"/>
    <dbReference type="InParanoid" id="A0A177BXI7"/>
    <dbReference type="OrthoDB" id="26569at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045009">
        <property type="term" value="C:chitosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004100">
        <property type="term" value="F:chitin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030476">
        <property type="term" value="P:ascospore wall assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000920">
        <property type="term" value="P:septum digestion after cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd04190">
        <property type="entry name" value="Chitin_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004835">
        <property type="entry name" value="Chitin_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013616">
        <property type="entry name" value="Chitin_synth_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914:SF9">
        <property type="entry name" value="CHITIN SYNTHASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01644">
        <property type="entry name" value="Chitin_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08407">
        <property type="entry name" value="Chitin_synth_1N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 10" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="4 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="605"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="638"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="672"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="716"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="848"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="888"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin synthase N-terminal" evidence="12">
        <location>
            <begin position="179"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="138"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU366040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OAG00063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="920" mass="104485" checksum="51AA01D4E6172F1E" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BYK3</accession>
    <name>A0A177BYK3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1053361</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441559">
        <property type="protein sequence ID" value="OAG00355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030720.1">
        <property type="nucleotide sequence ID" value="XM_018173503.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BYK3"/>
    <dbReference type="GeneID" id="28756989"/>
    <dbReference type="InParanoid" id="A0A177BYK3"/>
    <dbReference type="OrthoDB" id="5199481at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG00355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="176" mass="18356" checksum="A4A7CB7C10DB9A5E" modified="2016-09-07" version="1" fragment="single">AAALCTIVAAAPLAPWEVMAPPPSGTQFYQLQTKSATAAVSGQWVALKTGSTSYSLAAQQAAATKFFVNKYAPTGTFAVHNADDTRQLALQGPNGVLLSLVDATNPTTDSIPKGTLMEWATFTMDNNVLFVKDGSTLTNRTFVAVKGSGSDYSIALYDGASTTTSTITPVTINIVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BYV8</accession>
    <name>A0A177BYV8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS nicotinic acid transporter-like protein Tna1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_297222</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441559">
        <property type="protein sequence ID" value="OAG00336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030701.1">
        <property type="nucleotide sequence ID" value="XM_018185780.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BYV8"/>
    <dbReference type="FunCoup" id="A0A177BYV8">
        <property type="interactions" value="152"/>
    </dbReference>
    <dbReference type="GeneID" id="28769266"/>
    <dbReference type="InParanoid" id="A0A177BYV8"/>
    <dbReference type="OrthoDB" id="2962993at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17327">
        <property type="entry name" value="MFS_FEN2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000034">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000068">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF19">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G01812)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="131"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="159"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="191"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="224"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="296"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="337"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="361"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="386"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="421"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="453"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="65"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAG00336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="513" mass="57046" checksum="2E4BAAF698E4E8F0" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C0G8</accession>
    <name>A0A177C0G8_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">poly(ADP-ribose) glycohydrolase</fullName>
            <ecNumber evidence="2">3.2.1.143</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CC84DRAFT_1190185</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the poly(ADP-ribose) glycohydrolase family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.143" evidence="2"/>
    <dbReference type="EMBL" id="KV441558">
        <property type="protein sequence ID" value="OAG00975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031340.1">
        <property type="nucleotide sequence ID" value="XM_018181102.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C0G8"/>
    <dbReference type="STRING" id="1460663.A0A177C0G8"/>
    <dbReference type="GeneID" id="28764588"/>
    <dbReference type="InParanoid" id="A0A177C0G8"/>
    <dbReference type="OrthoDB" id="1937899at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004649">
        <property type="term" value="F:poly(ADP-ribose) glycohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990966">
        <property type="term" value="P:ATP generation from poly-ADP-D-ribose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009225">
        <property type="term" value="P:nucleotide-sugar metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006282">
        <property type="term" value="P:regulation of DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046372">
        <property type="entry name" value="PARG_cat_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048362">
        <property type="entry name" value="PARG_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007724">
        <property type="entry name" value="Poly_GlycHdrlase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12837">
        <property type="entry name" value="POLY ADP-RIBOSE GLYCOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12837:SF0">
        <property type="entry name" value="POLY(ADP-RIBOSE) GLYCOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05028">
        <property type="entry name" value="PARG_cat_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20811">
        <property type="entry name" value="PARG_cat_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PARG helical" evidence="5">
        <location>
            <begin position="85"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="PARG catalytic Macro" evidence="4">
        <location>
            <begin position="248"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF20811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAG00975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="513" mass="55831" checksum="2776943309D9BFDA" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C144</accession>
    <name>A0A177C144_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1190449</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441559">
        <property type="protein sequence ID" value="OAG00340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030705.1">
        <property type="nucleotide sequence ID" value="XM_018181118.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C144"/>
    <dbReference type="GeneID" id="28764604"/>
    <dbReference type="InParanoid" id="A0A177C144"/>
    <dbReference type="OrthoDB" id="4156595at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="68"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="175"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG00340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="201" mass="23093" checksum="E90A465EA6A6817E" modified="2016-09-07" version="1">MEAAPPRQRHGQRHFPPSPPSSPTARRRHKKKGSDDPFLRLGHPANHALTASPPSSPPNEADIADEPLYKRVILTPFLFTSFLVSLFLIDTQNAVARTKNSSLFSFLDPEPYQDPYDSRWGRRGSTPHVKPPDSLNPDQRSGGEKRKRRSWHLHRKIRKIAKLEISDAFEMRGRVMVAMVLILLMALYAAWYAFRWILNMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C1D9</accession>
    <name>A0A177C1D9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative choline transporter Hnm1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CC84DRAFT_1101423</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441558">
        <property type="protein sequence ID" value="OAG01246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031611.1">
        <property type="nucleotide sequence ID" value="XM_018174913.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C1D9"/>
    <dbReference type="STRING" id="1460663.A0A177C1D9"/>
    <dbReference type="GeneID" id="28758399"/>
    <dbReference type="InParanoid" id="A0A177C1D9"/>
    <dbReference type="OrthoDB" id="2417308at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF20">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="56"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="100"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="146"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="178"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="219"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="255"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="308"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="356"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="386"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="424"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="456"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAG01246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="491" mass="53510" checksum="B56C13348EE79958" modified="2016-09-07" version="1">MNADEVRLAEMGHVQELERHFSTLSLIGLASTTTISWTGLGLGIVTEINAGGPGAIIYGFVLVTMLQCFLGASLAEFVSSYPTEGGMYHWIAAVAPKTQSAFLSFLTGWFTVCGWIFTTASTNLIYAQTLGALIALYHPDMTVKTWEIFVIYQGLNLLTASVVLFGNKIIPSLNKFSLFYLQIGWLVVLVTVVACAPTHQSPEFVFRTWINNTGWENNVVAFAVGLVNPLYSLGGLDGVTHITEEMPNPSRNAPLAIAITLTIAFFTGLTYLIGLMFSVQDYSALGTTNTGLPLAELFRQATQSAGGAFGLTFILFIALGPCVISSQLSTSRVLWAFARDGAMPWSKTWARVSSRFGIPFNAQLLVTAANAALGCIYLGSSTAFNAMLGSAVTINNIAYYIPILTNMLTGRRNMYKGAFHMGKWGWLVNGVTICWLTFAIVFFSFPYSKPVTVQSMNYTCVVVGSLPILIIGWWFWVGKSYKEKIAVAKQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C1E5</accession>
    <name>A0A177C1E5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Di-copper centre-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1167658</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441557">
        <property type="protein sequence ID" value="OAG01463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031828.1">
        <property type="nucleotide sequence ID" value="XM_018179230.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C1E5"/>
    <dbReference type="STRING" id="1460663.A0A177C1E5"/>
    <dbReference type="GeneID" id="28762716"/>
    <dbReference type="InParanoid" id="A0A177C1E5"/>
    <dbReference type="OrthoDB" id="6132182at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1280.10">
        <property type="entry name" value="Di-copper center containing domain from catechol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008922">
        <property type="entry name" value="Di-copper_centre_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050316">
        <property type="entry name" value="Tyrosinase/Hemocyanin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002227">
        <property type="entry name" value="Tyrosinase_Cu-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474:SF116">
        <property type="entry name" value="TYROSINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474">
        <property type="entry name" value="TYROSINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00264">
        <property type="entry name" value="Tyrosinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00092">
        <property type="entry name" value="TYROSINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48056">
        <property type="entry name" value="Di-copper centre-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00498">
        <property type="entry name" value="TYROSINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosinase copper-binding" evidence="2">
        <location>
            <begin position="240"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG01463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="312" mass="35243" checksum="A65FE55253291CB3" modified="2016-09-07" version="1">MPHRMFSPEELVAIVDNGTQHGPESDFQGIQATCSNIRTRPEWHRTNDAFKQKFVDAVKCLFSRPSKGNYPGSRNRYEDFVQVHQKVALNVHSQGSLNAKFLVWHRAYLWAFEEALRGECGYSESLPWFDETLYPGRFSQSSIFSSKWLGAINLQGRCVTDGQFANLALNVGPGSGNQYHCLTRNGDASFTSQCTSANVEVCQRANDYQVFAQCEEGGLHAYGHVGTGGEMNDFFASPNDPVFWLHHGMVDRHFRIWQNDDGNRVNYVNGPGPDGKQLTMDTPIYLNGLKPDLKIRDIMNTIGGFLCYKYDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C2F2</accession>
    <name>A0A177C2F2_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">endo-polygalacturonase</fullName>
            <ecNumber evidence="3">3.2.1.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CC84DRAFT_1101328</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>(1,4-alpha-D-galacturonosyl)n+m + H2O = (1,4-alpha-D-galacturonosyl)n + (1,4-alpha-D-galacturonosyl)m.</text>
            <dbReference type="EC" id="3.2.1.15"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the glycosyl hydrolase 28 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.15" evidence="3"/>
    <dbReference type="EMBL" id="KV441558">
        <property type="protein sequence ID" value="OAG00988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031353.1">
        <property type="nucleotide sequence ID" value="XM_018174909.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C2F2"/>
    <dbReference type="FunCoup" id="A0A177C2F2">
        <property type="interactions" value="135"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177C2F2"/>
    <dbReference type="GeneID" id="28758395"/>
    <dbReference type="InParanoid" id="A0A177C2F2"/>
    <dbReference type="OrthoDB" id="1546079at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004650">
        <property type="term" value="F:polygalacturonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045490">
        <property type="term" value="P:pectin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.10:FF:000002">
        <property type="entry name" value="Endopolygalacturonase D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000743">
        <property type="entry name" value="Glyco_hydro_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050434">
        <property type="entry name" value="Glycosyl_hydrlase_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31884">
        <property type="entry name" value="POLYGALACTURONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31884:SF1">
        <property type="entry name" value="POLYGALACTURONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00295">
        <property type="entry name" value="Glyco_hydro_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00502">
        <property type="entry name" value="POLYGALACTURONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9 13" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 14" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008057654" description="endo-polygalacturonase" evidence="14">
        <location>
            <begin position="19"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="active site" evidence="12">
        <location>
            <position position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OAG00988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="381" mass="38394" checksum="A6D94EE731D2C697" modified="2016-09-07" version="1">MVFVFPALLASLAVLGNASPVAQPAITPAPKAPVAKRATSCTFSGSNGAASASASQTACSTIVLSNVAVPSGVTLDLSKLPDDTSVIFQGTTTWGYKEWAGPLLQIQGTGIKISGASGALLNPDGARWWDGGGGSSGKTKPKFFAAHNLISSSITNLHIQNTPVQAVSINGANGLTITGMTIDSSAGDSQGKNTDGFDIGSSTNVVIDGANVYNQDDCVAINSGTDITFQNGVCSGGHGLSIGSVGGRDNNVVDTVTFYNSEVKNSVNGIRIKGIENDTGTIKGVTYNKITLASISKYGILIEQNYDGGDLDGGTASSGIPITGLTIENISGSGAVSSSGYDVVVTCGSGACTGWTWSNVVVTGGKKYAKCTNVPSGVACS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C2H5</accession>
    <name>A0A177C2H5_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">linoleate 8R-lipoxygenase</fullName>
            <ecNumber evidence="3">1.13.11.60</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CC84DRAFT_1125986</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(9Z,12Z)-octadecadienoate + O2 = (8R,9Z,12Z)-8-hydroperoxyoctadeca-9,12-dienoate</text>
            <dbReference type="Rhea" id="RHEA:25395"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:30245"/>
            <dbReference type="ChEBI" id="CHEBI:58659"/>
            <dbReference type="EC" id="1.13.11.60"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homotetramer.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.60" evidence="3"/>
    <dbReference type="EMBL" id="KV441556">
        <property type="protein sequence ID" value="OAG01994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032359.1">
        <property type="nucleotide sequence ID" value="XM_018175735.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C2H5"/>
    <dbReference type="STRING" id="1460663.A0A177C2H5"/>
    <dbReference type="GeneID" id="28759221"/>
    <dbReference type="InParanoid" id="A0A177C2H5"/>
    <dbReference type="OrthoDB" id="823504at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052878">
        <property type="term" value="F:linoleate 8R-lipoxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20612">
        <property type="entry name" value="CYP_LDS-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09817">
        <property type="entry name" value="linoleate_diol_synthase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.640.10">
        <property type="entry name" value="Haem peroxidase domain superfamily, animal type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019791">
        <property type="entry name" value="Haem_peroxidase_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037120">
        <property type="entry name" value="Haem_peroxidase_sf_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050783">
        <property type="entry name" value="Oxylipin_biosynth_metab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034812">
        <property type="entry name" value="Ppo-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11903">
        <property type="entry name" value="PROSTAGLANDIN G/H SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11903:SF37">
        <property type="entry name" value="PSI-PRODUCING OXYGENASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03098">
        <property type="entry name" value="An_peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50292">
        <property type="entry name" value="PEROXIDASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="5 11" id="KW-0349">Heme</keyword>
    <keyword evidence="9 11" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 13" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="11">
        <location>
            <position position="366"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR619791-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OAG01994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="1063" mass="118788" checksum="60A37D74958236EA" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C2R7</accession>
    <name>A0A177C2R7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_278192</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441558">
        <property type="protein sequence ID" value="OAG01189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031554.1">
        <property type="nucleotide sequence ID" value="XM_018185736.1"/>
    </dbReference>
    <dbReference type="GeneID" id="28769222"/>
    <dbReference type="InParanoid" id="A0A177C2R7"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF16">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="614"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="266"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="410"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="540"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1337"/>
            <end position="1379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="413"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="476"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="544"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1337"/>
            <end position="1346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG01189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="1379" mass="150923" checksum="CCB4647B8BA15ECF" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C382</accession>
    <name>A0A177C382_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Apple domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CC84DRAFT_190285</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441557">
        <property type="protein sequence ID" value="OAG01369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031734.1">
        <property type="nucleotide sequence ID" value="XM_018185526.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C382"/>
    <dbReference type="STRING" id="1460663.A0A177C382"/>
    <dbReference type="GeneID" id="28769012"/>
    <dbReference type="InParanoid" id="A0A177C382"/>
    <dbReference type="OrthoDB" id="3943216at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd12087">
        <property type="entry name" value="TM_EGFR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.4.10">
        <property type="entry name" value="Hepatocyte Growth Factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051694">
        <property type="entry name" value="Immunoregulatory_rcpt-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003609">
        <property type="entry name" value="Pan_app"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549">
        <property type="entry name" value="PAIRED IMMUNOGLOBULIN-LIKE TYPE 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14295">
        <property type="entry name" value="PAN_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50948">
        <property type="entry name" value="PAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008057658" description="Apple domain-containing protein" evidence="7">
        <location>
            <begin position="22"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="392"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="8">
        <location>
            <begin position="268"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="358"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="362"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAG01369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="497" mass="53021" checksum="6F6BE547798C7BCD" modified="2016-09-07" version="1">MLGFSKNVSLAALLLASRTLATPLLESLIGRGLSLFPRADSKCVTSFTSGNGLNFTNVQCNQNNMYNDALAPFTVDTMTGCMEYCSRFWGSGEGCFGVVWRESDSQCWMRNSTTSELSNNKTIYTKTLIDEDGIHSALVDLNQMKPLDTDCPADDKSRHNLDGFDGISYTVQCNKDIGGSYDTHWSYEFHDNPFQAYYHATSLEDCLKDCVNEHPLCRGVVYVPGLTGGYANCWPKTGFSSPLSASNTLLKITHSATIDSIKTPDTECKNDTYTSTQDDSKNFAVHCGQTNQGTNMTMVQSQNFTACMEECAGNKQGCVGVVYDSTLQGGFNNCYLQNTSSIFNDVGSSMYAVLTGAKPKESGTGSSGSNSNSTDNSNNSNSNSSSSGGSKAWIAGAVVGPILGLALIGAAIFFLRRRKASGALANVSEVDGGDGKHNPYAHQGPTPAYAPVPQYSPQPTPSELGSGHGHQMVEMEGQTAKYAQKGAGAGGVVHEMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C3F5</accession>
    <name>A0A177C3F5_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HRQ family protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1167619</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441557">
        <property type="protein sequence ID" value="OAG01412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031777.1">
        <property type="nucleotide sequence ID" value="XM_018179217.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C3F5"/>
    <dbReference type="STRING" id="1460663.A0A177C3F5"/>
    <dbReference type="GeneID" id="28762703"/>
    <dbReference type="InParanoid" id="A0A177C3F5"/>
    <dbReference type="OrthoDB" id="497541at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021848">
        <property type="entry name" value="HODM_asu-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11927">
        <property type="entry name" value="HODM_asu-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG01412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="397" mass="45870" checksum="E67F698363FC29BB" modified="2016-09-07" version="1">MDSLLQSSAVTIFGLAACVLVLSVSLLRNLRKTDKALPVPRASTPGEKEKGEIRPFKTPLPEPARSYKLELTEPKLYRPFRHGKNFVTMGIRKMDWNEWIEMDSNFVRYHDIKVKQLDKDIDAHVGYVDNEVTRLACFEVYEELTQYLTHRFPEMFSLKDGTLRNSVTKEEFPYPASTPKEAMATSAKLIQDDIALMVMNDDGQYHLDAGAVCLPGFWRLKEKFRMSLDTLHIEAGVPHYQEKLMKSMNRFFARMTPDQPVIRNNFFIQLDDGLHWSHRMGDEKNVNQVASWANANSKDLTIDEIHFRSERQSLRRLPKSGALMFTIRTYFEPITVIAQEPHVPGRLAEAIRAWDGTVSHYKGRSHWEGLMLPYLDEMHRKQEESGALDTEEGEFPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C3G3</accession>
    <name>A0A177C3G3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1167285</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441556">
        <property type="protein sequence ID" value="OAG02163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032528.1">
        <property type="nucleotide sequence ID" value="XM_018179145.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C3G3"/>
    <dbReference type="STRING" id="1460663.A0A177C3G3"/>
    <dbReference type="GeneID" id="28762631"/>
    <dbReference type="InParanoid" id="A0A177C3G3"/>
    <dbReference type="OrthoDB" id="2991872at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053175">
        <property type="entry name" value="DHMBA_Reg_Transcription_Factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38791:SF1">
        <property type="entry name" value="TRANSCRIPTION FACTOR, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38791">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="2">
        <location>
            <begin position="10"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG02163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="640" mass="71065" checksum="0A25478449C6C424" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C3J7</accession>
    <name>A0A177C3J7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_190173</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441557">
        <property type="protein sequence ID" value="OAG01358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031723.1">
        <property type="nucleotide sequence ID" value="XM_018185523.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C3J7"/>
    <dbReference type="STRING" id="1460663.A0A177C3J7"/>
    <dbReference type="GeneID" id="28769009"/>
    <dbReference type="InParanoid" id="A0A177C3J7"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="164"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG01358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="348" mass="40039" checksum="07064C489063F33A" modified="2016-09-07" version="1">MARTMSRTSSTESVIGLNTEAMGAPETSKPSRRPLGSNLPGAPSLTSYVTARSTTSSYKTARSHFTEAGSIESSSHHRRRVDRIMYAFARSKGGAEMLERTIMHRDSNVAQKSQVPQPLLVVDSEWTEYLRERGILLDPLYELDWSGWGQHLEYKSSEETKIPLDTEKALGYSGTALVESVMCRRIRLARKTVRCSRRVTREEAIVEVEHLQRLLYSHIFRVVGTYTLRKDLAILLYPAAEYNLEQYMDHVTDTSSTYPTKPRSEYLSTFMGCLARTVRFLHESNVKHMDIKPRNILIRRKFDSIDQEWKVRTKTSIRFLTHGSFRYRLTLSGISGRLWNRTRLLECC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C4H3</accession>
    <name>A0A177C4H3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Dipeptidyl-peptidase V</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CC84DRAFT_1152669</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S9C family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441556">
        <property type="protein sequence ID" value="OAG02316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032681.1">
        <property type="nucleotide sequence ID" value="XM_018176813.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C4H3"/>
    <dbReference type="STRING" id="1460663.A0A177C4H3"/>
    <dbReference type="GeneID" id="28760299"/>
    <dbReference type="InParanoid" id="A0A177C4H3"/>
    <dbReference type="OrthoDB" id="416344at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000028">
        <property type="entry name" value="S9 family peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011659">
        <property type="entry name" value="WD40"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42776:SF11">
        <property type="entry name" value="DIPEPTIDYL-PEPTIDASE 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42776">
        <property type="entry name" value="SERINE PEPTIDASE S9 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07676">
        <property type="entry name" value="PD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="7" id="KW-0720">Serine protease</keyword>
    <keyword evidence="5 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008057794" description="Dipeptidyl-peptidase V" evidence="11">
        <location>
            <begin position="20"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S9 prolyl oligopeptidase catalytic" evidence="12">
        <location>
            <begin position="495"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="279"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="283"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OAG02316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="717" mass="78294" checksum="665FFB63C9058888" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C4T3</accession>
    <name>A0A177C4T3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1261445</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ustYa family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG02744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033109.1">
        <property type="nucleotide sequence ID" value="XM_018185068.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C4T3"/>
    <dbReference type="GeneID" id="28768554"/>
    <dbReference type="InParanoid" id="A0A177C4T3"/>
    <dbReference type="OrthoDB" id="3687641at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021765">
        <property type="entry name" value="UstYa-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365:SF12">
        <property type="entry name" value="TAT PATHWAY SIGNAL SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365">
        <property type="entry name" value="YALI0B05434P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11807">
        <property type="entry name" value="UstYa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00035112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG02744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="156" mass="17967" checksum="2B12A82FBF883260" modified="2016-09-07" version="1">MNFHATEEELHKANINIDDKVVRVSGGGYVGVLSVYHELHCLEALRRSTLRSHYYPGMTDKGLDHEDRVVEHLTHCIEYIRRTIMCHADVSVYTAVWIADSHEKPNKDLISGGERECVNWDAIDKWSRSRALKKKVYKVKPGPFEKDLHPNESDVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C4Z5</accession>
    <name>A0A177C4Z5_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">1-alkyl-2-acetylglycerophosphocholine esterase</fullName>
            <ecNumber evidence="1">3.1.1.47</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CC84DRAFT_218587</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.1.47" evidence="1"/>
    <dbReference type="EMBL" id="KV441557">
        <property type="protein sequence ID" value="OAG01787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032152.1">
        <property type="nucleotide sequence ID" value="XM_018185623.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C4Z5"/>
    <dbReference type="STRING" id="1460663.A0A177C4Z5"/>
    <dbReference type="GeneID" id="28769109"/>
    <dbReference type="InParanoid" id="A0A177C4Z5"/>
    <dbReference type="OrthoDB" id="2363873at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003847">
        <property type="term" value="F:1-alkyl-2-acetylglycerophosphocholine esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10272:SF14">
        <property type="entry name" value="PAF ACETYLHYDROLASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10272">
        <property type="entry name" value="PLATELET-ACTIVATING FACTOR ACETYLHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008057818" description="1-alkyl-2-acetylglycerophosphocholine esterase" evidence="5">
        <location>
            <begin position="19"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAG01787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="410" mass="44598" checksum="D681ACB24DBEE61F" modified="2016-09-07" version="1">MVLSCLYLFVPFIVRVSGLSLPPPTGPYNVGTKPYVLRHTTTNDTVAPEGVSKSVLVNVYYPTHDEAPAQKYIWDELGTAYDVYFGVAHGTFSNITATLAMNGKPLSRREHDKLRLPTLFFGPAMAGPPTRFFTGLISEMASRGYPVVTVDHPWEAPYIQYPNGTGFVGKSFLWNPCPEVIDDVQAYRLADNSAVLDALPKISKELGVPLDLRRFAFFGHSLGGSAAVSQLLVEKNRTTSHSKKFLGAINIDGTFFGIGGSNSSSLNTRVPTLLLSSDMHDPFAGHDPTWPLFESFQSSWTKSLRIVGHTNHSDYSDLIFLKQANGFAGGEGAITAERFLQVSRTVVGDFFEMLVGKGEGVLKGSAEVQQAFPEVSFDYNGTGNPCTPPDICWPPPPPPPEVVIPSCESS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C5K7</accession>
    <name>A0A177C5K7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1262037</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441556">
        <property type="protein sequence ID" value="OAG02007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032372.1">
        <property type="nucleotide sequence ID" value="XM_018185121.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C5K7"/>
    <dbReference type="GeneID" id="28768607"/>
    <dbReference type="InParanoid" id="A0A177C5K7"/>
    <dbReference type="OrthoDB" id="5353310at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="71"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG02007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="161" mass="17367" checksum="173F1D0FF5298B47" modified="2016-09-07" version="1">MAVQDPTFWKRFSIAVHQDDAAKQEMAQHAELKHSYVISLADMPSPTIIRPTSEAHLLRSHPRPLSPAVLSPHSPTTTHEPSSPSSTSHIKPLKKAYTPQSTKSTPFARHGNGSQLTLAFSGQIRGSKASAGSGGIARGFAGPSGYAYFCWSEAPSRQSWC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C5S1</accession>
    <name>A0A177C5S1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Oxidoreductase-like protein family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1166858</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG03104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033469.1">
        <property type="nucleotide sequence ID" value="XM_018179066.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C5S1"/>
    <dbReference type="FunCoup" id="A0A177C5S1">
        <property type="interactions" value="260"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177C5S1"/>
    <dbReference type="GeneID" id="28762552"/>
    <dbReference type="InParanoid" id="A0A177C5S1"/>
    <dbReference type="OrthoDB" id="64915at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006740">
        <property type="term" value="P:NADPH regeneration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42840:SF5">
        <property type="entry name" value="NAD(P)-BINDING ROSSMANN-FOLD SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42840">
        <property type="entry name" value="NAD(P)-BINDING ROSSMANN-FOLD SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="1">
        <location>
            <begin position="4"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase C-terminal" evidence="2">
        <location>
            <begin position="149"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG03104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="341" mass="36309" checksum="A698198096979060" modified="2016-09-07" version="1">MTIGIALIGSGIFAKEEHLPAIKAASALSLTAIYSRSLASAKSLASEAGDVELYSEDSGEGKGYDALLARDDVQAVVIALPILVQPEYIKKALSAGKHVLAEKPIAKDVATATELISWYKSNISGPSFSIAENFRFLASYDYAAAQFAQLGRVLGFRVRVQNFVKQGGKYFETAWRKKPEYQGGFLLDGGVHFVAATRLILESGGVKPVTTSAFSTQLQEHLPPVDTVDATVKLSNGANGTISLSFGTTFTGSEYTFAAEKGTVTVSRGKVTVVKDGKEETKEFPEEGNGVKQEIAAWGKALGEGKPDPRQSAEEALRDLQVLEAMLQSGEKGGAPVELKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C6X8</accession>
    <name>A0A177C6X8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNase I-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1207893</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG03156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033521.1">
        <property type="nucleotide sequence ID" value="XM_018182123.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C6X8"/>
    <dbReference type="FunCoup" id="A0A177C6X8">
        <property type="interactions" value="93"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177C6X8"/>
    <dbReference type="GeneID" id="28765609"/>
    <dbReference type="InParanoid" id="A0A177C6X8"/>
    <dbReference type="OrthoDB" id="62798at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004439">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046985">
        <property type="entry name" value="IP5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000300">
        <property type="entry name" value="IPPc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200:SF286">
        <property type="entry name" value="5-PHOSPHATASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G07600)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200">
        <property type="entry name" value="INOSITOL 5-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22669">
        <property type="entry name" value="Exo_endo_phos2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00128">
        <property type="entry name" value="IPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="404"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="domain" description="Inositol polyphosphate-related phosphatase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG03156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="425" mass="47095" checksum="9B521B1FE78BA959" modified="2016-09-07" version="1">MIDAYLLTFNCARHLVNPETLAPALFDGLPKAAAVPEVLALSLQEVAPIAYSFLGGSYLKPYFDRITTTVHLAADLHSHGSERLEHVATRSLGLTALMIFAKPGFMERIQYIQAAGTGVGVWNMGNKGAVAMRIGVSKPGSDEMLNVSFVAAHLTPHEKEVAARNKNWEDIVRNTVFATDNDSAYSYCDEAPLWASGEAPSGRTGLFHPDSHLFVAGDLNYRTSNEGPGPGAHETFPQPAASDALPEQFSHLLMTDQLNRERKANRTLHGLEELPIKFPPTYKYSLRKDKSENLMKPEDRWQWASHRYPSWCDRILYLPCPTSPSKLDPQIYTALPIQATSDHRPVALYVRIDDNALPADAGDIRSNPPFPINAEWKARNDAARRYEIVVGVMSYLVLTNKGKAMIVVLVGAVLATLYLTSWLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C732</accession>
    <name>A0A177C732_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">HAUS augmin-like complex subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CC84DRAFT_909564</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Spindle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HAUS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG02679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033044.1">
        <property type="nucleotide sequence ID" value="XM_018187863.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C732"/>
    <dbReference type="GeneID" id="28771349"/>
    <dbReference type="InParanoid" id="A0A177C732"/>
    <dbReference type="OrthoDB" id="5372507at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070652">
        <property type="term" value="C:HAUS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051225">
        <property type="term" value="P:spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026243">
        <property type="entry name" value="HAUS1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31570">
        <property type="entry name" value="HAUS AUGMIN-LIKE COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31570:SF1">
        <property type="entry name" value="HAUS AUGMIN-LIKE COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25762">
        <property type="entry name" value="HAUS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="7 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6" id="KW-0498">Mitosis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="47"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="197"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OAG02679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="300" mass="34037" checksum="39F4C198C3C995CC" modified="2016-09-07" version="1">MDNLTPQDLFSPSKARQQRAQAADWAQIDSWLSYKYAGRTVPTFERNEETLKVLRELSSANERADEERMIMERVEREACKELEADEESRDPEDVKILEAVEAHLSTEGSDALRALASTAVALDTTSANPETLAHALIAHTSMSQTLANNIQHVRTLQRYLDKQHTLLRSQLNELQSNPAFSAPPSLQRQTTEQARQTKHLRTKIREYEDRLASLEYQQAKTAATPASKGVSSAEAIADMLEQQTSLSALRRRVERLEKEVDEFAGLPADREAARKEVGKLEIELDNVRRRRDALFEELVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C751</accession>
    <name>A0A177C751_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Putative zinc-finger domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_1219879</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG02951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033316.1">
        <property type="nucleotide sequence ID" value="XM_018183119.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C751"/>
    <dbReference type="STRING" id="1460663.A0A177C751"/>
    <dbReference type="GeneID" id="28766605"/>
    <dbReference type="InParanoid" id="A0A177C751"/>
    <dbReference type="OrthoDB" id="1922977at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000178">
        <property type="term" value="C:exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019607">
        <property type="entry name" value="Putative_zinc-finger_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039278">
        <property type="entry name" value="Red1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21563">
        <property type="entry name" value="ZINC FINGER C3H1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21563:SF3">
        <property type="entry name" value="ZINC FINGER C3H1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10650">
        <property type="entry name" value="zf-C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Putative zinc-finger" evidence="3">
        <location>
            <begin position="1098"/>
            <end position="1119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="118"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="282"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="508"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="780"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="824"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="650"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="9"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="21"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="38"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="132"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="196"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="296"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="326"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="344"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="386"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="406"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="515"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="541"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="553"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="569"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="780"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="840"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="876"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="910"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="931"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="952"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="980"/>
            <end position="995"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1003"/>
            <end position="1012"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAG02951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="1190" mass="127440" checksum="5E7C64C52BEBD659" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C7V1</accession>
    <name>A0A177C7V1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Abnormal eversion of vulva protein 20</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CC84DRAFT_1165994</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">GTP-binding protein that functions in embryogenesis, cytokinesis, germline development and microtubulule cytoskeleton dynamics.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 17">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG03824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034189.1">
        <property type="nucleotide sequence ID" value="XM_018178847.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C7V1"/>
    <dbReference type="STRING" id="1460663.A0A177C7V1"/>
    <dbReference type="GeneID" id="28762333"/>
    <dbReference type="InParanoid" id="A0A177C7V1"/>
    <dbReference type="OrthoDB" id="2011769at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007021">
        <property type="term" value="P:tubulin complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd04154">
        <property type="entry name" value="Arl2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000981">
        <property type="entry name" value="ADP-ribosylation factor-like 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045873">
        <property type="entry name" value="Arl2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044612">
        <property type="entry name" value="ARL2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45697">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="9 15 17" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="11" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="16" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0519">Myristate</keyword>
    <keyword evidence="8 15 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="21"/>
            <end position="28"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="28"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="123"/>
            <end position="126"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00055307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00077919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU003925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="OAG03824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="181" mass="20915" checksum="84412060CCFF2280" modified="2016-09-07" version="1">MLSILRKARLKDKEMRILMLGLDNAGKTTIVKKIMNEDVNSVSPTLGFIIKTIEYDGYKLNIWDVGGQKTLRTYWKNYFEKTDTLIWVVDATDRERIDDCRRELEGLLQEERLMGASLLVFKNKSDVSGSMTEDEVRQGLRLDAIKTHKWTIMACSAMTGTNLQEGLRWVVQDAKSRLFLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C8P7</accession>
    <name>A0A177C8P7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_960216</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG03148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033513.1">
        <property type="nucleotide sequence ID" value="XM_018187960.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C8P7"/>
    <dbReference type="GeneID" id="28771446"/>
    <dbReference type="InParanoid" id="A0A177C8P7"/>
    <dbReference type="OrthoDB" id="5089392at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008057881" evidence="1">
        <location>
            <begin position="17"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG03148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="401" mass="42277" checksum="4F6B756EB2C15F93" modified="2016-09-07" version="1">MSAIFASLLLVTAVNAKVLPREEARKSSMRDPASFFSATSLPFEDPETTISNDFPTPTTIFDPSTTTMFPNFTFTEFPSVSFSSPDFSGTFFIPIPSQADYLSVTVPACTQADGEVVDSIVVIGVPTGTFSPGITKTIVVPPQANPTTATFYDYPPNNDTEVVIVEPLPGNCGPFITPTNAFAPTGTESSAEPSNTAAACPTKGCSGAVLRAAETVINAINDVTQISFALQTGARKIGAGIFGRDDVSVNADVDLFSNPITDVALGLTRITTTVQTALPTFITFPPFPPSCSSDTIVLAWLEFVRVHQELLAILIGRSGLLETGPLKRSSVVNHADGTPITRGEQGFVGRPIAVALRGIEGVVDTLAVGIADLVPGKSECSEKKSAELKEKIKKAQMSYEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C960</accession>
    <name>A0A177C960_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Methyl-accepting transducer domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1219167</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG03916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034281.1">
        <property type="nucleotide sequence ID" value="XM_018183060.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C960"/>
    <dbReference type="STRING" id="1460663.A0A177C960"/>
    <dbReference type="GeneID" id="28766546"/>
    <dbReference type="InParanoid" id="A0A177C960"/>
    <dbReference type="OrthoDB" id="10653529at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008057903" description="Methyl-accepting transducer domain-containing protein" evidence="2">
        <location>
            <begin position="19"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="270"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="44"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="273"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG03916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="310" mass="31995" checksum="26A34E3CFEC962E6" modified="2016-09-07" version="1">MKTAYSLLTLLSVSLVVAGPLPINRNDERAVASTAPAPAPAPAITPEAPSAGDAEAQKAAEEKAAADHKAQADAMEAMHVAEAEAREKAHQEAAAKMEAMHVAEAEAKDKAAQEAAAKMEAMHVAEAQAKDKAAQEAAAKAEAEHKAKLEAEAAADKAAADKAAKEKENAEKEAARLEAEKLKEEDGKKKTEEDAARAEAEKVKKEEEEKKKAAEELAAKGNASLLHEPAAQNTSVAEAIHPVGNATVVSEATSTVEHVLPAETAAAVVEHPAGPPAPLTPPAPKAEEAEAGKHPLAGENVANVTENTRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C9Z4</accession>
    <name>A0A177C9Z4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Carbon catabolite repressor CreA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CC84DRAFT_1166091</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the creA/MIG C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG03941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034306.1">
        <property type="nucleotide sequence ID" value="XM_018178872.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C9Z4"/>
    <dbReference type="STRING" id="1460663.A0A177C9Z4"/>
    <dbReference type="GeneID" id="28762358"/>
    <dbReference type="InParanoid" id="A0A177C9Z4"/>
    <dbReference type="OrthoDB" id="654211at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000433">
        <property type="term" value="P:carbon catabolite repression of transcription from RNA polymerase II promoter by glucose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043609">
        <property type="term" value="P:regulation of carbon utilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000089">
        <property type="entry name" value="DNA-binding protein creA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000152">
        <property type="entry name" value="DNA-binding protein creA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051007">
        <property type="entry name" value="creA/MIG_C2H2-ZnF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47428">
        <property type="entry name" value="REGULATORY PROTEIN MIG1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47428:SF1">
        <property type="entry name" value="REGULATORY PROTEIN MIG1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="71"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="99"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="112"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="153"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="263"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="402"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="23"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="163"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="271"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="301"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="405"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OAG03941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="427" mass="46278" checksum="4DDEDCCBF498D328" modified="2016-09-07" version="1">MQPSAQQIGSYNLSSVLNHEPTHQQNSSPQTTPQTTADAPMATATVSLMAPLLQNAQQDEQRPSGDLPRPYKCPLCEKAFHRLEHQTRHIRTHTGEKPHACTFPGCSKRFSRSDELTRHSRIHNNPNSRRGNKQHAAAAAAVAAGMIEPNTMAHMMPPPPSNKVISRSAPSSNIGSPNVSPPHSFSNYSPNVSSDLASYRSGSNSSSPNGLARNIDLLADAASRLEQRHGHHYSYASRHVTSHGYHPYQNNHRLPGLAQYAYSSQPMSRSHSHEDDDPYAHRMTKKSRPGSPLSTAPPSPTFSHDSCSPTPDHTPLATPAHSPRLRPHGFNDVQLPHLRHLSLHHVPALAPMEPSTHTEAPYVPAQNSGGLRIGDIISKPEGAQRKLPIPQIPKVAVQDLLNAPSGLSSGNSSTTASVAGNDLSDRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CAR1</accession>
    <name>A0A177CAR1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1219133</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG03878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034243.1">
        <property type="nucleotide sequence ID" value="XM_018183058.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CAR1"/>
    <dbReference type="GeneID" id="28766544"/>
    <dbReference type="InParanoid" id="A0A177CAR1"/>
    <dbReference type="OrthoDB" id="4159781at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540:SF10">
        <property type="entry name" value="SIGMA-70 REGION 2 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540">
        <property type="entry name" value="TRANSCRIPTION FACTOR (ACR-2), PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG03878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="280" mass="32580" checksum="57F960426C525F73" modified="2016-09-07" version="1">MAMYENLRGSDQVITHERGLGQMFDMRGGIEKFMSEKGFYIGNYAMLVDMMHSACSNKQPLFTEVKRPILRDPHVGMRKQYFPHSPLRVANNPGFNATVSIEELRSSLDVLRDAFDGLEMLCIEVFDPNTATTEGLRFRHRRDKFWTRLQARDISETEPNELTTEGKVKEAIRLTGTIHCCAVVSQIQHDDELNMQYVLRLHEVLKKLQLDFWKTAPYLYLWILLTGGAACSRLPEPRAYFVSEIARVGMSIGFFDWQPFTQSINNFLWLQEFLRKRTKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CAR4</accession>
    <name>A0A177CAR4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CHK kinase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1249337</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG03919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034284.1">
        <property type="nucleotide sequence ID" value="XM_018184283.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CAR4"/>
    <dbReference type="GeneID" id="28767769"/>
    <dbReference type="InParanoid" id="A0A177CAR4"/>
    <dbReference type="OrthoDB" id="191037at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015897">
        <property type="entry name" value="CHK_kinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004119">
        <property type="entry name" value="EcKL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052961">
        <property type="entry name" value="Oxido-Kinase-like_Enzymes"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23020:SF41">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23020">
        <property type="entry name" value="UNCHARACTERIZED NUCLEAR HORMONE RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02958">
        <property type="entry name" value="EcKL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00587">
        <property type="entry name" value="CHK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CHK kinase-like" evidence="1">
        <location>
            <begin position="147"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG03919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="382" mass="42979" checksum="C9971CB5C1E7B261" modified="2016-09-07" version="1">MVAILDSYEECAAAPVSDGPPGINTVYSDGISPTAGLPVVPGDITAEWLSQVLKRKVSSVALGRTIPGTATKVFIAVTFEDEKDPKGLPVRLCVKGGFDPDFIKMMPWIVMIYQRECDFYNQVAPKLDNMKLPAFWWAGHSSTQGIVILDDLAAQGCDFGNPAESWPVSRVLAGVEQLAALHAKTWHTQASDYPWLTSDYDQAILTLMNTYDAVVKGPNRPKIHDYLKDQERITKVLEKHYALRNPRFRCLLHGDSHTGNTYLVTDVPRFLDWQMIHIGSAFHDLSYFIGAALSAEDRRAKEWNVVEHYLRVLEKLGVEPLSVSDKEVRNEYKMSFLAGIGWIMCPYEMQIRECVHPMAMRYAAAIDDHKVLELVERLPEPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CAT0</accession>
    <name>A0A177CAT0_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mannose-1-phosphate guanyltransferase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">GDP-mannose pyrophosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">GTP-mannose-1-phosphate guanylyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Translation initiation factor eIF2B subunit gamma</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">eIF2B GDP-GTP exchange factor subunit gamma</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CC84DRAFT_1166086</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Acts as a component of the translation initiation factor 2B (eIF2B) complex, which catalyzes the exchange of GDP for GTP on the eukaryotic initiation factor 2 (eIF2) complex gamma subunit. Its guanine nucleotide exchange factor activity is repressed when bound to eIF2 complex phosphorylated on the alpha subunit, thereby limiting the amount of methionyl-initiator methionine tRNA available to the ribosome and consequently global translation is repressed.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Component of the translation initiation factor 2B (eIF2B) complex which is a heterodecamer of two sets of five different subunits: alpha, beta, gamma, delta and epsilon. Subunits alpha, beta and delta comprise a regulatory subcomplex and subunits epsilon and gamma comprise a catalytic subcomplex. Within the complex, the hexameric regulatory complex resides at the center, with the two heterodimeric catalytic subcomplexes bound on opposite sides.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eIF-2B gamma/epsilon subunits family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG03939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034304.1">
        <property type="nucleotide sequence ID" value="XM_018178870.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CAT0"/>
    <dbReference type="STRING" id="1460663.A0A177CAT0"/>
    <dbReference type="GeneID" id="28762356"/>
    <dbReference type="InParanoid" id="A0A177CAT0"/>
    <dbReference type="OrthoDB" id="10250549at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005851">
        <property type="term" value="C:eukaryotic translation initiation factor 2B complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002183">
        <property type="term" value="P:cytoplasmic translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04652">
        <property type="entry name" value="LbH_eIF2B_gamma_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051960">
        <property type="entry name" value="eIF2B_gamma"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056729">
        <property type="entry name" value="GMPPB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45989">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45989:SF1">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25087">
        <property type="entry name" value="GMPPB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 16" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nucleotidyl transferase" evidence="14">
        <location>
            <begin position="31"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="Mannose-1-phosphate guanyltransferase C-terminal" evidence="15">
        <location>
            <begin position="447"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="548"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="549"/>
            <end position="572"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00045373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00046432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF25087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OAG03939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="572" mass="62133" checksum="9A01A29AFC2CD30E" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CBF7</accession>
    <name>A0A177CBF7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Low temperature requirement A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1147973</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG04945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035310.1">
        <property type="nucleotide sequence ID" value="XM_018176614.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CBF7"/>
    <dbReference type="STRING" id="1460663.A0A177CBF7"/>
    <dbReference type="GeneID" id="28760100"/>
    <dbReference type="InParanoid" id="A0A177CBF7"/>
    <dbReference type="OrthoDB" id="3177213at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010640">
        <property type="entry name" value="Low_temperature_requirement_A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42101">
        <property type="entry name" value="CHROMOSOME 16, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42101:SF1">
        <property type="entry name" value="LOW TEMPERATURE REQUIREMENT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06772">
        <property type="entry name" value="LtrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="78"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="147"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="180"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="217"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="281"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="470"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="497"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="527"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="574"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="616"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="648"/>
            <end position="658"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG04945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="679" mass="76582" checksum="99F0A671D029B3C6" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CBQ1</accession>
    <name>A0A177CBQ1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uracil permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_1246206</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG04292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034657.1">
        <property type="nucleotide sequence ID" value="XM_018184192.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CBQ1"/>
    <dbReference type="GeneID" id="28767678"/>
    <dbReference type="InParanoid" id="A0A177CBQ1"/>
    <dbReference type="OrthoDB" id="2018619at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015205">
        <property type="term" value="F:nucleobase transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11482">
        <property type="entry name" value="SLC-NCS1sbd_NRT1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.4160.10:FF:000001">
        <property type="entry name" value="Uracil permease, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4160.10">
        <property type="entry name" value="Hydantoin permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012681">
        <property type="entry name" value="NCS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045225">
        <property type="entry name" value="Uracil/uridine/allantoin_perm"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00800">
        <property type="entry name" value="ncs1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30618">
        <property type="entry name" value="NCS1 FAMILY PURINE/PYRIMIDINE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30618:SF0">
        <property type="entry name" value="PURINE-URACIL PERMEASE NCS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="45"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="76"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="112"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="171"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="195"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="236"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="275"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="323"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="364"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="391"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="429"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="469"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="520"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="534"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAG04292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="544" mass="60453" checksum="D0AFB1973294A1AA" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CC48</accession>
    <name>A0A177CC48_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NACHT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CC84DRAFT_1196565</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG04338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034703.1">
        <property type="nucleotide sequence ID" value="XM_018181472.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CC48"/>
    <dbReference type="STRING" id="1460663.A0A177CC48"/>
    <dbReference type="GeneID" id="28764958"/>
    <dbReference type="InParanoid" id="A0A177CC48"/>
    <dbReference type="OrthoDB" id="538223at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001638">
        <property type="entry name" value="NACHT and WD40 domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF13">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50837">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="NACHT" evidence="4">
        <location>
            <begin position="296"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="823"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="865"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="907"/>
            <end position="948"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAG04338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="1063" mass="119628" checksum="AFE79CD1256F652A" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CCM7</accession>
    <name>A0A177CCM7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_1260216</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG04931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035296.1">
        <property type="nucleotide sequence ID" value="XM_018184976.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CCM7"/>
    <dbReference type="STRING" id="1460663.A0A177CCM7"/>
    <dbReference type="GeneID" id="28768462"/>
    <dbReference type="InParanoid" id="A0A177CCM7"/>
    <dbReference type="OrthoDB" id="4682787at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF160">
        <property type="entry name" value="SAT4 FAMILY MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="77"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="157"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="202"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="238"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="280"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="61"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAG04931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="393" mass="43454" checksum="5DA137E8BBA0D62A" modified="2016-09-07" version="1">MAIEDAFRDLTATQRQAALEGPALMPPPGVTPNFINPPNQNKLGYGLIYSCAVVCAAVVCIRLYASLICRKKMNIEDYLAIVALGVTGGFLYISFRILLVPGLYVHQWNVQLKDLAMILFNVNNNYILYGIIIMLLKAAILLEWTHLFVPLGIRNGFWWTCHAILWANVMFYIACTVVENFSCAPREKIWNKLIEGHCVNNPALIMSSGILNMVSDVVIFALPQKMIWSLHISTRKRVGICLLFATGAFGCVCGAVRLVWTTKALGADDITFNVGPIGLWSVGELTSGFLVLCVPSFPKVFKDSIIARKLASLANRLSGATRSNGMSNLRHGLPSWYRPSAPRRPQRSQFSEIEEFTVPVTQPQSCMAYGDLPRDDSGTRGLGMVFKNAVSED</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CD81</accession>
    <name>A0A177CD81_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CC84DRAFT_1187661</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">ATP-dependent RNA helicase involved in 40S ribosomal subunit biogenesis. Required for the processing and cleavage of 35S pre-rRNA at sites A0, A1, and A2, leading to mature 18S rRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the DEAD box helicase family. DDX48/FAL1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG04660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035025.1">
        <property type="nucleotide sequence ID" value="XM_018180945.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CD81"/>
    <dbReference type="FunCoup" id="A0A177CD81">
        <property type="interactions" value="620"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CD81"/>
    <dbReference type="GeneID" id="28764431"/>
    <dbReference type="InParanoid" id="A0A177CD81"/>
    <dbReference type="OrthoDB" id="10265785at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18045">
        <property type="entry name" value="DEADc_EIF4AIII_DDX48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000031">
        <property type="entry name" value="Eukaryotic initiation factor 4A-III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000498">
        <property type="entry name" value="Eukaryotic initiation factor 4A-III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 15 19" id="KW-0347">Helicase</keyword>
    <keyword evidence="6 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="18">
        <location>
            <begin position="25"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="16">
        <location>
            <begin position="56"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="17">
        <location>
            <begin position="237"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="14">
        <location>
            <begin position="25"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00037945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="OAG04660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="399" mass="45544" checksum="7F95060C490EA78E" modified="2016-09-07" version="1">MAETIDRNMDDKMEFSTSKEVTVAPTFEAMHLKENLLRGIYAYGYESPSAVQSRAIVQICKGRDTIAQAQSGTGKTATFSISILQVIDTAVRETQALVLSPTRELATQIQSVIMGLGDYMNVQCHACIGGTNVGEDIRKLDYGQHVVSGTPGRVADMIRRRNLRTRNIKMLVLDEADELLNRGFREQIYDVYRYLPPATQVVVVSATLPYDVLEMTTKFMTEPVRILVKRDELTLEGLKQYFIAIEKEEWKFDTLCDLYDTLTITQAVIFCNTRRKVDWLTDKMREANFTVSSMHGDMPQRERDSIMQDFRQANSRVLISTDVWARGIDVQQVSLVINYDLPSNRENYIHRIGRSGRFGRKGVAINFVTQEDVRILRDIELYYSTQIDEMPMNVADLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CDR4</accession>
    <name>A0A177CDR4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ferroxidase</fullName>
            <ecNumber evidence="3">1.16.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CC84DRAFT_1121976</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>4 Fe(2+) + O2 + 4 H(+) = 4 Fe(3+) + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:11148"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.16.3.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the frataxin family.</text>
    </comment>
    <dbReference type="EC" id="1.16.3.1" evidence="3"/>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG05042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035407.1">
        <property type="nucleotide sequence ID" value="XM_018175623.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CDR4"/>
    <dbReference type="FunCoup" id="A0A177CDR4">
        <property type="interactions" value="417"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CDR4"/>
    <dbReference type="GeneID" id="28759109"/>
    <dbReference type="InParanoid" id="A0A177CDR4"/>
    <dbReference type="OrthoDB" id="1897642at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004322">
        <property type="term" value="F:ferroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034986">
        <property type="term" value="F:iron chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.920.10:FF:000004">
        <property type="entry name" value="Mitochondrial chaperone Frataxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.920.10">
        <property type="entry name" value="Frataxin/CyaY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017789">
        <property type="entry name" value="Frataxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002908">
        <property type="entry name" value="Frataxin/CyaY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036524">
        <property type="entry name" value="Frataxin/CyaY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020895">
        <property type="entry name" value="Frataxin_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03421">
        <property type="entry name" value="FeS_CyaY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03422">
        <property type="entry name" value="mito_frataxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16821">
        <property type="entry name" value="FRATAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16821:SF2">
        <property type="entry name" value="FRATAXIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01491">
        <property type="entry name" value="Frataxin_Cyay"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00904">
        <property type="entry name" value="FRATAXIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01219">
        <property type="entry name" value="Frataxin_Cyay"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55387">
        <property type="entry name" value="Frataxin/Nqo15-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01344">
        <property type="entry name" value="FRATAXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50810">
        <property type="entry name" value="FRATAXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0409">Iron storage</keyword>
    <keyword evidence="6" id="KW-0410">Iron transport</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="58"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OAG05042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="205" mass="22377" checksum="45A342E32EC8AACB" modified="2016-09-07" version="1">MKSLSRAGQVALRRAVRTPLRAQMSANGVIARAPVAVARASGASTAVRGFHSSMTLKGIMPESENPAPPQSEDSEHPTVPTDISTSEFHERADEYLEELLGELEAKQEETPDYDVEYSAGVMHVKIQSRGHEYVLNKQPPNKQIWWSSPVSGPKRFDWVVMGEGLHQKEGGGAGDWIYLRDGTSLSDLVRQELGVALGKDDSAPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CDS1</accession>
    <name>A0A177CDS1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">acetylglutamate kinase</fullName>
            <ecNumber evidence="6">2.7.2.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">CC84DRAFT_1094734</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23 24">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>N-acetyl-L-glutamate + ATP = N-acetyl-L-glutamyl 5-phosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:14629"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:44337"/>
            <dbReference type="ChEBI" id="CHEBI:57936"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 19">Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 2/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 19">Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 3/4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 19">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 19">In the C-terminal section; belongs to the NAGSA dehydrogenase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 19">In the N-terminal section; belongs to the acetylglutamate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.8" evidence="6"/>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG05062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035427.1">
        <property type="nucleotide sequence ID" value="XM_018174581.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CDS1"/>
    <dbReference type="FunCoup" id="A0A177CDS1">
        <property type="interactions" value="105"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CDS1"/>
    <dbReference type="GeneID" id="28758067"/>
    <dbReference type="InParanoid" id="A0A177CDS1"/>
    <dbReference type="OrthoDB" id="438291at2759"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00107"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003991">
        <property type="term" value="F:acetylglutamate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003942">
        <property type="term" value="F:N-acetyl-gamma-glutamyl-phosphate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070401">
        <property type="term" value="F:NADP+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042450">
        <property type="term" value="P:L-arginine biosynthetic process via ornithine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd04252">
        <property type="entry name" value="AAK_NAGK-fArgBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23936">
        <property type="entry name" value="AGPR_C_ARG5_6_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd24149">
        <property type="entry name" value="AGPR_N_ARG5_6_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04263">
        <property type="entry name" value="DUF619-NAGK-FABP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.10:FF:000019">
        <property type="entry name" value="Bifunctional acetylglutamate kinase/N-acetyl-gamma-glutamyl-phosphate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000029">
        <property type="entry name" value="Bifunctional acetylglutamate kinase/N-acetyl-gamma-glutamyl-phosphate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1160.10:FF:000046">
        <property type="entry name" value="N-acetylglutamate kinase / N-acetylglutamate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="entry name" value="Acetylglutamate kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00150">
        <property type="entry name" value="ArgC_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004662">
        <property type="entry name" value="AcgluKinase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023013">
        <property type="entry name" value="AGPR_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058924">
        <property type="entry name" value="AGPR_dimerisation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000706">
        <property type="entry name" value="AGPR_type-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041734">
        <property type="entry name" value="NAGK-fArgBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011241">
        <property type="entry name" value="NAGK/NAGSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000534">
        <property type="entry name" value="Semialdehyde_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006855">
        <property type="entry name" value="Vertebrate-like_GNAT_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00761">
        <property type="entry name" value="argB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01850">
        <property type="entry name" value="argC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23342">
        <property type="entry name" value="N-ACETYLGLUTAMATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23342:SF0">
        <property type="entry name" value="N-ACETYLGLUTAMATE SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04768">
        <property type="entry name" value="NAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01118">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22698">
        <property type="entry name" value="Semialdhyde_dhC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036440">
        <property type="entry name" value="ARG5-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00859">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="Carbamate kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01224">
        <property type="entry name" value="ARGC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51731">
        <property type="entry name" value="GNAT_NAGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 19" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7 19" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="12 19" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11 19 23" id="KW-0418">Kinase</keyword>
    <keyword evidence="16 19" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="17 19" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="13 19" id="KW-0521">NADP</keyword>
    <keyword evidence="10 19" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15 19" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 19" id="KW-0808">Transferase</keyword>
    <keyword evidence="14" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="22">
        <location>
            <begin position="341"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="531"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="531"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="active site" evidence="20">
        <location>
            <position position="713"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00048141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRNR" id="PIRNR036440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="OAG05062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="894" mass="98785" checksum="F29A15D5C47A8232" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CE98</accession>
    <name>A0A177CE98_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Amino acid transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_1148185</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG05060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035425.1">
        <property type="nucleotide sequence ID" value="XM_018176623.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CE98"/>
    <dbReference type="FunCoup" id="A0A177CE98">
        <property type="interactions" value="108"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CE98"/>
    <dbReference type="GeneID" id="28760109"/>
    <dbReference type="InParanoid" id="A0A177CE98"/>
    <dbReference type="OrthoDB" id="2417308at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015101">
        <property type="term" value="F:organic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000046">
        <property type="entry name" value="Amino-acid permease, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF7">
        <property type="entry name" value="CHOLINE TRANSPORT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="46"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="81"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="124"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="171"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="202"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="243"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="279"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="331"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="385"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="411"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="445"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="482"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAG05060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="533" mass="58086" checksum="7860187B3F7CEB32" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CEF3</accession>
    <name>A0A177CEF3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_828658</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG05147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035512.1">
        <property type="nucleotide sequence ID" value="XM_018187552.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CEF3"/>
    <dbReference type="GeneID" id="28771038"/>
    <dbReference type="InParanoid" id="A0A177CEF3"/>
    <dbReference type="OrthoDB" id="10670387at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG05147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="270" mass="29895" checksum="E68284A69039CAE4" modified="2016-09-07" version="1">MPPNQVVVDYAERPRGEGNASDLTLRCSHPRRSRAQRQTVFGASVSQDRRQTRSKDFAPAPRLAYCTRFGRLCPTCPPIPNQQYRRPASNLEAVCTPLHSSAITIMQPRGGIDPRNSAGVTGAAGRDRAPGHANGATELSPKAQDERRNKRLGKTALKMYVKFRRPDTAHCCAFQNPLAIVQAPMIPIPLAAPEHVLLVHRSPKVAGKAVFHARRHLMQLAAEKPRKKLQGPLANQCRASRNLISPGVSRHYNDDFENDANVCVRPEMLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CEM0</accession>
    <name>A0A177CEM0_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">TLDc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1175878</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG05756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036121.1">
        <property type="nucleotide sequence ID" value="XM_018180178.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CEM0"/>
    <dbReference type="STRING" id="1460663.A0A177CEM0"/>
    <dbReference type="GeneID" id="28763664"/>
    <dbReference type="InParanoid" id="A0A177CEM0"/>
    <dbReference type="OrthoDB" id="5377405at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG05756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="515" mass="57849" checksum="05C56C7A26DD02BE" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CFD1</accession>
    <name>A0A177CFD1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Probable 26S proteasome regulatory subunit p27</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_1164337</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome subunit p27 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG05921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036286.1">
        <property type="nucleotide sequence ID" value="XM_018178466.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CFD1"/>
    <dbReference type="FunCoup" id="A0A177CFD1">
        <property type="interactions" value="1077"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CFD1"/>
    <dbReference type="GeneID" id="28761952"/>
    <dbReference type="InParanoid" id="A0A177CFD1"/>
    <dbReference type="OrthoDB" id="72325at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044183">
        <property type="term" value="F:protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070682">
        <property type="term" value="P:proteasome regulatory particle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000107">
        <property type="entry name" value="26S proteasome non-ATPase regulatory subunit 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040815">
        <property type="entry name" value="Nas2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041489">
        <property type="entry name" value="PDZ_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035269">
        <property type="entry name" value="PSMD9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12651">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12651:SF1">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18265">
        <property type="entry name" value="Nas2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17820">
        <property type="entry name" value="PDZ_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0647">Proteasome</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nas2 N-terminal" evidence="7">
        <location>
            <begin position="29"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="6">
        <location>
            <begin position="141"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="22"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00068021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF17820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF18265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAG05921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="229" mass="24448" checksum="5669560A56C442E0" modified="2016-09-07" version="1">MDDLHAPTVASGPTTGGYSNGVSKDQLSLQELMAEKDRVEAELKALGQVLDSHGVNMNTTLTTFDGFPRADVDVAQIRTTRARIIRLKNDYKDLMARIEKGLHEHHARLQEQAQNNTATSAFSLSAGGAAPAAVEAPFAKVNSVVAGSPAETAGLQVGDSITKFGWVDWTNHDKLARLAQVVSQNEGLPIIVKALRPSAAGPAETIEMRLTPRSNWGGRGMLGCNLLPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CFY4</accession>
    <name>A0A177CFY4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Autophagy-related protein 101</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_1164117</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATG101 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG05640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036005.1">
        <property type="nucleotide sequence ID" value="XM_018178415.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CFY4"/>
    <dbReference type="STRING" id="1460663.A0A177CFY4"/>
    <dbReference type="GeneID" id="28761901"/>
    <dbReference type="InParanoid" id="A0A177CFY4"/>
    <dbReference type="OrthoDB" id="10259639at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990316">
        <property type="term" value="C:Atg1/ULK1 kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012445">
        <property type="entry name" value="ATG101"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13292">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13292:SF0">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07855">
        <property type="entry name" value="ATG101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0072">Autophagy</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAG05640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="201" mass="23214" checksum="8507DEB598361AD9" modified="2016-09-07" version="1">MEPRRRPEYHLDIFADLACVKDVVKAILHTIFFHRYFTSISPLTRDLLDLTLPAIDDVDLETLIDQRTIALVRAIESTHQQRGRGQLVVQFFEKRRRKTYFFGKADEDVCWEQWTLDVTLATPRTETDVLKVRRAMTKSLEKAAHKIITIVNRDKDHIPPITTTDANPFPYQVIVNPKAVPDQNAWGPRMGIFSNASQTAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CG20</accession>
    <name>A0A177CG20_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Kinesin light chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1142451</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG06554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036919.1">
        <property type="nucleotide sequence ID" value="XM_018176368.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CG20"/>
    <dbReference type="STRING" id="1460663.A0A177CG20"/>
    <dbReference type="GeneID" id="28759854"/>
    <dbReference type="InParanoid" id="A0A177CG20"/>
    <dbReference type="OrthoDB" id="428577at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053137">
        <property type="entry name" value="NLR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082:SF11">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082">
        <property type="entry name" value="ATP/GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13374">
        <property type="entry name" value="TPR_10"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="308"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="313"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG06554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1173" mass="132701" checksum="48E62FDEBF00A9F1" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CGE4</accession>
    <name>A0A177CGE4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ferric-chelate reductase (NADPH)</fullName>
            <ecNumber evidence="3">1.16.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CC84DRAFT_764075</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>2 a Fe(II)-siderophore + NADP(+) + H(+) = 2 a Fe(III)-siderophore + NADPH</text>
            <dbReference type="Rhea" id="RHEA:28795"/>
            <dbReference type="Rhea" id="RHEA-COMP:11342"/>
            <dbReference type="Rhea" id="RHEA-COMP:11344"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.16.1.9"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ferric reductase (FRE) family.</text>
    </comment>
    <dbReference type="EC" id="1.16.1.9" evidence="3"/>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG06426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036791.1">
        <property type="nucleotide sequence ID" value="XM_018187354.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CGE4"/>
    <dbReference type="STRING" id="1460663.A0A177CGE4"/>
    <dbReference type="GeneID" id="28770840"/>
    <dbReference type="InParanoid" id="A0A177CGE4"/>
    <dbReference type="OrthoDB" id="4494341at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052851">
        <property type="term" value="F:ferric-chelate reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015677">
        <property type="term" value="P:copper ion import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013112">
        <property type="entry name" value="FAD-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051410">
        <property type="entry name" value="Ferric/Cupric_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361">
        <property type="entry name" value="FERRIC/CUPRIC REDUCTASE TRANSMEMBRANE COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361:SF24">
        <property type="entry name" value="REDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G10820)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08022">
        <property type="entry name" value="FAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00052">
        <property type="entry name" value="Ferric_Reductase_Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01168">
        <property type="entry name" value="Ferric_reductase_subgroup_(FRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="37"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="194"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="225"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="261"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="14">
        <location>
            <begin position="301"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OAG06426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="595" mass="67206" checksum="758640E9DFC35712" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CGM9</accession>
    <name>A0A177CGM9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Senescence domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1092052</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG05847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036212.1">
        <property type="nucleotide sequence ID" value="XM_018174430.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CGM9"/>
    <dbReference type="STRING" id="1460663.A0A177CGM9"/>
    <dbReference type="GeneID" id="28757916"/>
    <dbReference type="InParanoid" id="A0A177CGM9"/>
    <dbReference type="OrthoDB" id="20821at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009686">
        <property type="entry name" value="Senescence/spartin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045036">
        <property type="entry name" value="Spartin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21068">
        <property type="entry name" value="SPARTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21068:SF43">
        <property type="entry name" value="SPARTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06911">
        <property type="entry name" value="Senescence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Senescence" evidence="2">
        <location>
            <begin position="247"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="470"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="500"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG05847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="520" mass="54280" checksum="0C48EF5E67E94DDF" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CGN0</accession>
    <name>A0A177CGN0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CC84DRAFT_1174664</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG06733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037098.1">
        <property type="nucleotide sequence ID" value="XM_018180107.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CGN0"/>
    <dbReference type="STRING" id="1460663.A0A177CGN0"/>
    <dbReference type="GeneID" id="28763593"/>
    <dbReference type="InParanoid" id="A0A177CGN0"/>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19071">
        <property type="entry name" value="AKR_AKR1-5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11732">
        <property type="entry name" value="ALDO/KETO REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008058181" evidence="5">
        <location>
            <begin position="17"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="6">
        <location>
            <begin position="35"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="70"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="4">
        <location>
            <position position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAG06733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="338" mass="37562" checksum="58593DE5F8EAF27B" modified="2016-09-07" version="1">MLVQIAFAALVGVAHCRNKQHPILLRPEGIEQPLIGFGTWNLKESPENTTNAVAFAIEKGYKQIDCAAAYGNEEAVGKGIHKGLKKAGLKREEIWVTSKLWNDHHAPDRVEAGLDKTLKDLGLDYLDLYLMHWPVGKGLDDKMYHYDYVDTWKSMAELLKSGRVRRIGICNFSPAQLKELVKHSLKGDSPLPAVHQMELHPYLPQAKWIYAHKAHGIAVTAYSPLGNMNPTYGDRLRRSVTTQSKGPLLLENKVIKSIAKKRECTPAQVVLKWGVSRGTSVIPKSKHEKYIEENLGATGCGLGTDDLADIDELGEEPVRFNNPSDGWGVHLFDGLDDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CGW5</accession>
    <name>A0A177CGW5_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CC84DRAFT_1092346</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG05947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036312.1">
        <property type="nucleotide sequence ID" value="XM_018174447.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CGW5"/>
    <dbReference type="STRING" id="1460663.A0A177CGW5"/>
    <dbReference type="GeneID" id="28757933"/>
    <dbReference type="InParanoid" id="A0A177CGW5"/>
    <dbReference type="OrthoDB" id="10018191at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000065">
        <property type="entry name" value="B-cell CLL/lymphoma 6, member B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001732">
        <property type="entry name" value="Zgc:162936"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051059">
        <property type="entry name" value="VerF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626">
        <property type="entry name" value="MIP31509P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626:SF11">
        <property type="entry name" value="ZINC FINGER PROTEIN YPR022C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="13"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="41"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAG05947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="67" mass="7805" checksum="A2C56E8B19D65328" modified="2016-09-07" version="1" fragment="single">MSTSPARGITPAFPCAFCDQSFGRKEHLTRHRRIHTQEKPFRCSSCTKCFSRLDVLNRHISTHEEQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CH65</accession>
    <name>A0A177CH65_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">alkaline phosphatase</fullName>
            <ecNumber evidence="1">3.1.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CC84DRAFT_1090178</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="3">Binds 1 Mg(2+) ion.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="3">Binds 2 Zn(2+) ions.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the alkaline phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.1" evidence="1"/>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG06914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037279.1">
        <property type="nucleotide sequence ID" value="XM_018174344.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CH65"/>
    <dbReference type="STRING" id="1460663.A0A177CH65"/>
    <dbReference type="GeneID" id="28757830"/>
    <dbReference type="InParanoid" id="A0A177CH65"/>
    <dbReference type="OrthoDB" id="5818554at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004035">
        <property type="term" value="F:alkaline phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16012">
        <property type="entry name" value="ALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001952">
        <property type="entry name" value="Alkaline_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11596">
        <property type="entry name" value="ALKALINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11596:SF72">
        <property type="entry name" value="ALKALINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00245">
        <property type="entry name" value="Alk_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00113">
        <property type="entry name" value="ALKPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00098">
        <property type="entry name" value="alkPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008058287" description="alkaline phosphatase" evidence="6">
        <location>
            <begin position="22"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="564"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="564"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphoserine intermediate" evidence="2">
        <location>
            <position position="220"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="279"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="281"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="436"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="441"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="445"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="486"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="487"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="610"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR601952-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR601952-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAG06914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="656" mass="71841" checksum="1D7BAF73545BCF8A" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CHF4</accession>
    <name>A0A177CHF4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Beta-xylanase</fullName>
            <ecNumber evidence="10">3.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CC84DRAFT_1164582</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>Endohydrolysis of (1-&gt;4)-beta-D-xylosidic linkages in xylans.</text>
            <dbReference type="EC" id="3.2.1.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Glycan degradation; xylan degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the glycosyl hydrolase 10 (cellulase F) family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.8" evidence="10"/>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG06279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036644.1">
        <property type="nucleotide sequence ID" value="XM_018178515.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CHF4"/>
    <dbReference type="STRING" id="1460663.A0A177CHF4"/>
    <dbReference type="GeneID" id="28762001"/>
    <dbReference type="InParanoid" id="A0A177CHF4"/>
    <dbReference type="OrthoDB" id="3055998at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031176">
        <property type="term" value="F:endo-1,4-beta-xylanase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044846">
        <property type="entry name" value="GH10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001000">
        <property type="entry name" value="GH10_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31490:SF35">
        <property type="entry name" value="ENDO-1,4-BETA-XYLANASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31490">
        <property type="entry name" value="GLYCOSYL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00331">
        <property type="entry name" value="Glyco_hydro_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00134">
        <property type="entry name" value="GLHYDRLASE10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00633">
        <property type="entry name" value="Glyco_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51760">
        <property type="entry name" value="GH10_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 10 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 10" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0858">Xylan degradation</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008058190" description="Beta-xylanase" evidence="11">
        <location>
            <begin position="17"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="domain" description="GH10" evidence="12">
        <location>
            <begin position="45"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OAG06279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="362" mass="41094" checksum="9139961F0ED1B4E9" modified="2016-09-07" version="1" fragment="single">MKTTLLLAALPAAATALPTWPWTKPHHDNPKPNKYPNKYPGLNVLAQKAGLKYFGTAIDNVVLDNPTYIAIAHNRSEFGQVTPSNGQKWELIEPQQNKFNYTLGDQITVPATKAKQLKRCHNFVWHNQLPQWLTGRNWTKPELINVLENHIKNEARHYYNDCFAWDVVNEAFEDDAVASLRKDIWLNTIGKEYIELAFKFARKYTKPGTKLYYNDYAIERVNNKSRAVAAMVKDFKQRHIPIDGVGLQAHYTVGRAPTYDDQLATHKLFSDLGVETALTELDVRIQLPDNATLQAQQAAVYANSTKACLDADDCVGITVWDFWDPVSWVPGTFPGFGNADIWDANFTKKPAYYAVSDLLRSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CHX8</accession>
    <name>A0A177CHX8_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alcohol dehydrogenase-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_1217674</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG06459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036824.1">
        <property type="nucleotide sequence ID" value="XM_018182918.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CHX8"/>
    <dbReference type="STRING" id="1460663.A0A177CHX8"/>
    <dbReference type="GeneID" id="28766404"/>
    <dbReference type="InParanoid" id="A0A177CHX8"/>
    <dbReference type="OrthoDB" id="48317at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047122">
        <property type="entry name" value="Trans-enoyl_RdTase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348">
        <property type="entry name" value="HYPOTHETICAL OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348:SF2">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE PROTEIN C2E1P3.01"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like C-terminal" evidence="3">
        <location>
            <begin position="211"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAG06459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="339" mass="36677" checksum="770618A0F9802B2D" modified="2016-09-07" version="1">MREYENAKRAGKASYLRELRRMCHVEIQGAGLLIHQTALLEPSVTTDDLEAAEHLHLAKTQHEQHSPPQHHEGPRYAFPVGSCRGARWSSPSHTFAHQPLIKTVHAAVNPVDIFVSEFGLLVESWPPVPGCEASRIFVRVGAKARNPLGRYFKEGNVVAGCARVLAVGNVTFAEYFLLNAGGAFEAWGFDDDGNGAGAWSWAIVFGGAGVVGKYAVQALKLAGCRVATTCSTTSFELLKSLGAHATIDYRTSPEEVVEEVKRVTQEKLELAYDAVSVNNDLISKIFTAVPTSSSSQRLYTTMNDWDPAPDASLGFITKSIALGPIGRPSTAELNSKVNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CK62</accession>
    <name>A0A177CK62_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1173499</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG07905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038270.1">
        <property type="nucleotide sequence ID" value="XM_018180041.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CK62"/>
    <dbReference type="GeneID" id="28763527"/>
    <dbReference type="InParanoid" id="A0A177CK62"/>
    <dbReference type="OrthoDB" id="3800607at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="264"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="516"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="600"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="715"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="228"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="280"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="546"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="715"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="740"/>
            <end position="751"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG07905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="751" mass="82212" checksum="CCE95B3E830BB86D" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CL85</accession>
    <name>A0A177CL85_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1162079</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038431.1">
        <property type="nucleotide sequence ID" value="XM_018177900.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CL85"/>
    <dbReference type="GeneID" id="28761386"/>
    <dbReference type="InParanoid" id="A0A177CL85"/>
    <dbReference type="OrthoDB" id="5363415at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018858">
        <property type="entry name" value="DUF2458"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10454">
        <property type="entry name" value="DUF2458"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG08066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="258" mass="28981" checksum="1444FB2DFAF6B229" modified="2016-09-07" version="1">MADNNLSPELNLEQILATLASLPQTTTPPVPFEQQIHPQGLFDAQSTGTPASHYPSQTRILYEQSQDPRLNARPQTTLSNRQAPPNSRTTPSPIDPATITEWKHGLRCVNKIATQNPAFVPAVQKLIADQARNVKDWESGRQRLIEEQAVKRENEQTHLAVLSLPGMSDKIAPLRTVEVEKEELEMYGNKVYRAAQRMVELQFKDLKGLGVPFFGLRSEFLRSDGSDEGDESGKKVTKGELLELQRKMLNHLMELYGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CLF9</accession>
    <name>A0A177CLF9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RlpA-like protein double-psi beta-barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_1163739</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG07617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037982.1">
        <property type="nucleotide sequence ID" value="XM_018178327.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CLF9"/>
    <dbReference type="STRING" id="1460663.A0A177CLF9"/>
    <dbReference type="GeneID" id="28761813"/>
    <dbReference type="InParanoid" id="A0A177CLF9"/>
    <dbReference type="OrthoDB" id="406505at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22191">
        <property type="entry name" value="DPBB_RlpA_EXP_N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="entry name" value="RlpA-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051477">
        <property type="entry name" value="Expansin_CellWall"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836:SF28">
        <property type="entry name" value="SRCR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50685">
        <property type="entry name" value="Barwin-like endoglucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008058439" description="RlpA-like protein double-psi beta-barrel domain-containing protein" evidence="3">
        <location>
            <begin position="18"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="76"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="76"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="119"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAG07617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="276" mass="27639" checksum="E248FF1FBC18B934" modified="2016-09-07" version="1">MKSSIVASALFASLALAAPLNKRAYATKTNTVVETVVVYTTVWGNQPPATSAPAAATSSPALFFEKPSSAAAVTSSEVAPKVPSSTPEPVVPSFTPAPEPVSSEAPSSSAVPVVESTPSPSPEPTPTPQVTPEAAPSSTTPVVEATPSAEPSTGGGSSGGQEYTGSLTMNYYSGGLGACGEAIQDTEMVAALAVAGFGDSTYDSATGNPTNKWCNQKIRVTYNGKSADAVIKDRCPGCTGQGGLDATPALWEALTGGQGGASGDRLESGMSFTLLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CLG4</accession>
    <name>A0A177CLG4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF4360 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1163822</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG07708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038073.1">
        <property type="nucleotide sequence ID" value="XM_018178345.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CLG4"/>
    <dbReference type="STRING" id="1460663.A0A177CLG4"/>
    <dbReference type="GeneID" id="28761831"/>
    <dbReference type="InParanoid" id="A0A177CLG4"/>
    <dbReference type="OrthoDB" id="152248at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025649">
        <property type="entry name" value="DUF4360"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38847">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38847:SF1">
        <property type="entry name" value="PSEUDOURIDINE SYNTHASE RSUA_RLUA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14273">
        <property type="entry name" value="DUF4360"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012091075" description="DUF4360 domain-containing protein" evidence="1">
        <location>
            <begin position="16"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG07708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="263" mass="28584" checksum="0268FEAE77A44981" modified="2016-09-07" version="1">MRYTTLLLLPTIALAAPAPLPVPQDKPSGHEVEITAVTYGGTGCPDRTVQGLLSDDRTTITLSFDQYTVQSGPNIPATERRKFCQLQLKLKYPSGFQYSVFGADYRGYASLEKDVTGTAQSTYYFSGQQNQVCVPTRCRLPQPQPAACSSPRNPSSPALTHLTQTVIPTTFKGPMEGNYLKHDEVDAGSTVWSPCGEQGMLNIKSEVRIVPFTAKGLNLLTVDTVDAKFSQKYYVQWQRCDGKTGGGSGGMPIGRPPVDLGRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CLH6</accession>
    <name>A0A177CLH6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_557512</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038521.1">
        <property type="nucleotide sequence ID" value="XM_018186684.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CLH6"/>
    <dbReference type="GeneID" id="28770170"/>
    <dbReference type="InParanoid" id="A0A177CLH6"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG08156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="100" mass="10613" checksum="FE414AB9C1B834DE" modified="2016-09-07" version="1">MTTTARNDSRVASMSALNPPRPANHTVGDENRPLLRAIDKRQTVATAISPSALRSSRRAVAVAHHLASVVQSLVIPDSTCGEAVASQHPIRLVHSPKHGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CM99</accession>
    <name>A0A177CM99_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Vacuolar protein sorting-associated protein 35</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_1162081</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Plays a role in vesicular protein sorting.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the VPS35 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038437.1">
        <property type="nucleotide sequence ID" value="XM_018177901.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CM99"/>
    <dbReference type="FunCoup" id="A0A177CM99">
        <property type="interactions" value="1275"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CM99"/>
    <dbReference type="GeneID" id="28761387"/>
    <dbReference type="InParanoid" id="A0A177CM99"/>
    <dbReference type="OrthoDB" id="10258141at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030906">
        <property type="term" value="C:retromer, cargo-selective complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.660:FF:000002">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.660">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 35, helical subcomplex Vps35-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005378">
        <property type="entry name" value="Vps35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042491">
        <property type="entry name" value="Vps35_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11099:SF0">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11099">
        <property type="entry name" value="VACUOLAR SORTING PROTEIN 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03635">
        <property type="entry name" value="Vps35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009375">
        <property type="entry name" value="Retromer_Vps35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="335"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="352"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR009375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAG08072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="885" mass="100031" checksum="9991BFC52DE47BBC" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CMC0</accession>
    <name>A0A177CMC0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1162036</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038375.1">
        <property type="nucleotide sequence ID" value="XM_018177890.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CMC0"/>
    <dbReference type="GeneID" id="28761376"/>
    <dbReference type="InParanoid" id="A0A177CMC0"/>
    <dbReference type="OrthoDB" id="10362666at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG08010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="61" mass="6936" checksum="5590152323CC97A2" modified="2016-09-07" version="1">MTIPAFRGFPFYTCSATGTLHMGTIRPDNPRVYAADKRPELERGFKCAAHLHREEVDANRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CMC7</accession>
    <name>A0A177CMC7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Receptor L-domain domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_1239013</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG07959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038324.1">
        <property type="nucleotide sequence ID" value="XM_018183969.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CMC7"/>
    <dbReference type="STRING" id="1460663.A0A177CMC7"/>
    <dbReference type="GeneID" id="28767455"/>
    <dbReference type="InParanoid" id="A0A177CMC7"/>
    <dbReference type="OrthoDB" id="536881at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008058368" description="Receptor L-domain domain-containing protein" evidence="3">
        <location>
            <begin position="23"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="320"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="272"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAG07959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="445" mass="46163" checksum="E2FB6B8D2DEE38E2" modified="2016-09-07" version="1">MFRDSFLYAWAVVQVCMRVAHALDCHSLIGLTISSPSDVAALNKCTNITAPVTINSSAPPDIQLNGPKALATLNATAAKSLHSISSSTLVEIGSITLTDLPTFHSLNFSALIVLDALALENLPALDDVTFGGLGPRSVVSVVNTALESVEWVEWPVSTSLNISSNADLEEISLPWDSVDGAVSISNNEKLDRLDVRGMKSITGSFTVEENDGLKTLAFGSLESVKGDVQLSGSFANISMPMLKKVTGTLAISSKEDIDASCAEIVKVDDSGKVNCTPNAQSHPPASPTPSNSPGNPPSPSSSATPDEGEDTSDLATGAKIGIVTAAVILGLFLVVGGVFFFRARSRGKVREIVISAPIPVPPHTTSSGQSVKSVGSISVGEVERAEAKVVGRSAGGLKLILNGEEMREVDMAGARVEGGGVGMEREASLSSVSSMGSKVPLVRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CME2</accession>
    <name>A0A177CME2_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glycine cleavage system P protein</fullName>
            <ecNumber evidence="7">1.4.4.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CC84DRAFT_1114227</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">The glycine cleavage system catalyzes the degradation of glycine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 7">
            <text>N(6)-[(R)-lipoyl]-L-lysyl-[glycine-cleavage complex H protein] + glycine + H(+) = N(6)-[(R)-S(8)-aminomethyldihydrolipoyl]-L-lysyl-[glycine-cleavage complex H protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:24304"/>
            <dbReference type="Rhea" id="RHEA-COMP:10494"/>
            <dbReference type="Rhea" id="RHEA-COMP:10495"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83143"/>
            <dbReference type="EC" id="1.4.4.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 6 7">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="7">The glycine cleavage system is composed of four proteins: P, T, L and H.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the GcvP family.</text>
    </comment>
    <dbReference type="EC" id="1.4.4.2" evidence="7"/>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038413.1">
        <property type="nucleotide sequence ID" value="XM_018175389.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CME2"/>
    <dbReference type="FunCoup" id="A0A177CME2">
        <property type="interactions" value="703"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CME2"/>
    <dbReference type="GeneID" id="28758875"/>
    <dbReference type="InParanoid" id="A0A177CME2"/>
    <dbReference type="OrthoDB" id="6537869at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005960">
        <property type="term" value="C:glycine cleavage complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016594">
        <property type="term" value="F:glycine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004375">
        <property type="term" value="F:glycine dehydrogenase (decarboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019464">
        <property type="term" value="P:glycine decarboxylation via glycine cleavage system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00613">
        <property type="entry name" value="GDC-P"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000005">
        <property type="entry name" value="Glycine dehydrogenase (decarboxylating), mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000007">
        <property type="entry name" value="glycine dehydrogenase (Decarboxylating), mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000007">
        <property type="entry name" value="Glycine dehydrogenase (decarboxylating), mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003437">
        <property type="entry name" value="GcvP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049316">
        <property type="entry name" value="GDC-P_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049315">
        <property type="entry name" value="GDC-P_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020581">
        <property type="entry name" value="GDC_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00461">
        <property type="entry name" value="gcvP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11773:SF1">
        <property type="entry name" value="GLYCINE DEHYDROGENASE (DECARBOXYLATING), MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11773">
        <property type="entry name" value="GLYCINE DEHYDROGENASE, DECARBOXYLATING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21478">
        <property type="entry name" value="GcvP2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02347">
        <property type="entry name" value="GDC-P"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3 6 7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Glycine cleavage system P-protein N-terminal" evidence="8">
        <location>
            <begin position="82"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="domain" description="Glycine cleavage system P-protein N-terminal" evidence="8">
        <location>
            <begin position="589"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="domain" description="Glycine dehydrogenase C-terminal" evidence="9">
        <location>
            <begin position="887"/>
            <end position="1008"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="6">
        <location>
            <position position="815"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR603437-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF21478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAG08048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="1079" mass="117972" checksum="D2E65DC833C30891" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CMH4</accession>
    <name>A0A177CMH4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ATP synthase subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CC84DRAFT_1115415</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Subunit b, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel. These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. In vivo, can only synthesize ATP although its ATP hydrolase activity can be activated artificially in vitro. Part of the complex F(0) domain. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9 10">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. In yeast, the dimeric form of ATP synthase consists of 17 polypeptides: alpha, beta, gamma, delta, epsilon, 4 (B), 5 (OSCP), 6 (A), 8, 9 (C), d, E (Tim11), f, g, h, i/j and k.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the eukaryotic ATPase B chain family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039078.1">
        <property type="nucleotide sequence ID" value="XM_018175426.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CMH4"/>
    <dbReference type="FunCoup" id="A0A177CMH4">
        <property type="interactions" value="436"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CMH4"/>
    <dbReference type="GeneID" id="28758912"/>
    <dbReference type="InParanoid" id="A0A177CMH4"/>
    <dbReference type="OrthoDB" id="67388at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.2210:FF:000002">
        <property type="entry name" value="ATP synthase subunit 4 mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.2210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008688">
        <property type="entry name" value="ATP_synth_Bsub_B/MI25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013837">
        <property type="entry name" value="ATP_synth_F0_suB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12733:SF3">
        <property type="entry name" value="ATP SYNTHASE F(0) COMPLEX SUBUNIT B1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12733">
        <property type="entry name" value="MITOCHONDRIAL ATP SYNTHASE B CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05405">
        <property type="entry name" value="Mt_ATP-synt_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161060">
        <property type="entry name" value="ATP synthase B chain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0138">CF(0)</keyword>
    <keyword evidence="4 10" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="6 10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 10" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00062152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU368017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OAG08713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="244" mass="26487" checksum="CA05C959A15C40C9" modified="2016-09-07" version="1">MASRLARSAVGAARLRPSLPLRTLPSITAQITPARYQSNVPEDPKKKAQSLLDAIPVPGNSPITKAAVLSAAAGVSTFAISNELYVVNEESIVALSLLTIFWAVAKYAGPAWSDYAQSQIDKISGILNSARADHTTAVKQRIESVQDLGGVIDITKNLFAVSKETAQLEAQAYELEQKTAIAHEAKTVLDSWVRYEGQVKARQQRELAESIIAKIEKELENPKTLKQILDQSVADVERIVSQKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CML0</accession>
    <name>A0A177CML0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ubiquitin fusion degradation protein-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_558160</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UFD1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038547.1">
        <property type="nucleotide sequence ID" value="XM_018186691.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CML0"/>
    <dbReference type="STRING" id="1460663.A0A177CML0"/>
    <dbReference type="GeneID" id="28770177"/>
    <dbReference type="InParanoid" id="A0A177CML0"/>
    <dbReference type="OrthoDB" id="193703at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034098">
        <property type="term" value="C:VCP-NPL4-UFD1 AAA ATPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031593">
        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.50">
        <property type="entry name" value="Ubiquitin fusion degradation protein UFD1, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.130.10">
        <property type="entry name" value="Ubiquitin-protein ligase E3A, N-terminal zinc-binding domain (AZUL)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032353">
        <property type="entry name" value="AZUL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042556">
        <property type="entry name" value="AZUL_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056012">
        <property type="entry name" value="DUF7590"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004854">
        <property type="entry name" value="Ufd1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042299">
        <property type="entry name" value="Ufd1-like_Nn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055417">
        <property type="entry name" value="UFD1_N1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055418">
        <property type="entry name" value="UFD1_N2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12555:SF15">
        <property type="entry name" value="FUSION DEGRADATION PROTEIN (UFD1), PUTATIVE (AFU_ORTHOLOGUE AFUA_4G04640)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12555">
        <property type="entry name" value="UBIQUITIN FUSION DEGRADATON PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16558">
        <property type="entry name" value="AZUL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24503">
        <property type="entry name" value="DUF7590"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03152">
        <property type="entry name" value="UFD1_N1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24842">
        <property type="entry name" value="UFD1_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23580">
        <property type="entry name" value="Znf_XAF1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Ubiquitin fusion degradation protein UFD1 N-terminal subdomain 1" evidence="4">
        <location>
            <begin position="84"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin fusion degradation protein UFD1 N-terminal subdomain 2" evidence="7">
        <location>
            <begin position="174"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7590" evidence="6">
        <location>
            <begin position="281"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-protein ligase E3A N-terminal zinc-binding" evidence="5">
        <location>
            <begin position="660"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="403"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF24503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF24842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAG08182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="786" mass="86932" checksum="ED2FF1F3C0DD2D90" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CN39</accession>
    <name>A0A177CN39_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">FAD dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_1114689</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MSOX/MTOX family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038685.1">
        <property type="nucleotide sequence ID" value="XM_018175404.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CN39"/>
    <dbReference type="STRING" id="1460663.A0A177CN39"/>
    <dbReference type="GeneID" id="28758890"/>
    <dbReference type="InParanoid" id="A0A177CN39"/>
    <dbReference type="OrthoDB" id="2219495at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051698">
        <property type="term" value="F:saccharopine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008115">
        <property type="term" value="F:sarcosine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045170">
        <property type="entry name" value="MTOX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10961:SF26">
        <property type="entry name" value="L-SACCHAROPINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10961">
        <property type="entry name" value="PEROXISOMAL SARCOSINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="7">
        <location>
            <begin position="11"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="416"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="424"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAG08320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="440" mass="49083" checksum="C6296599368259BF" modified="2016-09-07" version="1">MAILRVDTKFIIVGGGGTIGSSTALHLLRYGYTPSNITVLDTYEIPSAQSAGNDLNKIMGIRLRNKVDVQLSLEARDMWKNDDLFKAFFHNTGRLDCEHTEEGIRDLRKQYQTLLDAGVGLEKTNEWLETEDQILEKAPQLEREKIKGWKAIFSEDGGWLAAAKAIRAIGLYLKEQGVNFGFGGAGSFKKPLFAEDSATCIGVETADGTQYYADKVVLAAGAWSSVLVDLDDQCVSKAWVYAHMRLTPQEVAEYKNAPVVYNGDVGFFFEPDEYGVIKVCDEFPGFTRFKEHQPYGAKAPRQISVPRSHAKHPTDTYPDASEKSIRRAIDTFLPRFKNKKLFNRSLCWCTDTADAALLICEHPKWKNLIMATGDSGHTFKLLPNIGKHVVELVEGDLAEDLANAWRWRPGGDALKSRRAAPAKDLADMPGWKHDTPKPKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CNA9</accession>
    <name>A0A177CNA9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">HTH araC/xylS-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_1115366</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039056.1">
        <property type="nucleotide sequence ID" value="XM_018175424.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CNA9"/>
    <dbReference type="STRING" id="1460663.A0A177CNA9"/>
    <dbReference type="GeneID" id="28758910"/>
    <dbReference type="InParanoid" id="A0A177CNA9"/>
    <dbReference type="OrthoDB" id="2447880at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.10.10">
        <property type="entry name" value="DNA Methylphosphotriester Repair Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035451">
        <property type="entry name" value="Ada-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004026">
        <property type="entry name" value="Ada_DNA_repair_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02805">
        <property type="entry name" value="Ada_Zn_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57884">
        <property type="entry name" value="Ada DNA repair protein, N-terminal domain (N-Ada 10)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0010">Activator</keyword>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="7">
        <location>
            <begin position="85"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="137"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAG08691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="286" mass="31289" checksum="B693B6E13442058D" modified="2016-09-07" version="1">MSYTTDASRWRALSTRDPASATAFVYTVKSTRIYCRPTCPARLARRANVGFCSTPAEASATGFRPCKRCKPDTAITEDPQEKAVARACRLIEEGVKRGEEGREGLRLQELAKRVGLTPRYFHKIFKERMGVTPREWARGKMGGVDGEGQREGTSETRTPSLVLDSPPEMDGSNLDAFNFNELVDFGGNAGIAGDAMEMDPAMAPMEGFGEPFDVNASMCGWDTFAPDYLGEGFRLDDTLLKWTDGSLVSDAAMAKTSTTFEQDAALLLDMSRVTDLNDTLYVDALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CNL3</accession>
    <name>A0A177CNL3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">NEDD8-activating enzyme E1 catalytic subunit</fullName>
            <ecNumber evidence="8 10">6.2.1.64</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CC84DRAFT_1257841</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalytic subunit of the dimeric E1 enzyme, which activates NEDD8.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>ATP + [NEDD8 protein] + [E1 NEDD8-activating enzyme]-L-cysteine = AMP + diphosphate + [E1 NEDD8-activating enzyme]-S-[NEDD8 protein]-yl-L-cysteine.</text>
            <dbReference type="EC" id="6.2.1.64"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Protein modification; protein neddylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the ubiquitin-activating E1 family. UBA3 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.64" evidence="8 10"/>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG09125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039490.1">
        <property type="nucleotide sequence ID" value="XM_018184768.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CNL3"/>
    <dbReference type="FunCoup" id="A0A177CNL3">
        <property type="interactions" value="1197"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CNL3"/>
    <dbReference type="GeneID" id="28768254"/>
    <dbReference type="InParanoid" id="A0A177CNL3"/>
    <dbReference type="OrthoDB" id="10255449at2759"/>
    <dbReference type="UniPathway" id="UPA00885"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019781">
        <property type="term" value="F:NEDD8 activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045116">
        <property type="term" value="P:protein neddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01488">
        <property type="entry name" value="Uba3_RUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.520:FF:000001">
        <property type="entry name" value="NEDD8-activating enzyme E1 catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.80:FF:000002">
        <property type="entry name" value="SUMO-activating enzyme subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.290.20:FF:000003">
        <property type="entry name" value="Ubiquitin-activating enzyme E1 C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.520">
        <property type="entry name" value="Ubiquitin activating enzymes (Uba3). Chain: B, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.20">
        <property type="entry name" value="Ubiquitin-like 2 activating enzyme e1b. Chain: B, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014929">
        <property type="entry name" value="E2-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023318">
        <property type="entry name" value="Ub_act_enz_dom_a_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030468">
        <property type="entry name" value="Uba3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF6">
        <property type="entry name" value="NEDD8-ACTIVATING ENZYME E1 CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08825">
        <property type="entry name" value="E2_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01181">
        <property type="entry name" value="E2_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="E2 binding" evidence="11">
        <location>
            <begin position="354"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU368009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OAG09125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="438" mass="48838" checksum="81AB9FC0313805D2" modified="2016-09-07" version="1">MAAADVVPLPNGSEGTRTRWKYLDRILDRPGPFTDPDSFAPGNHETLEIAKVLVIGAGGLGCEILKNLALSGFKDIHVIDMDTIDVSNLNRQFLFRAADVGKFKAEVAAAFVEKRVKGVKITPYCGKIQDKDEAYYKQFALIVCGLDSIEARRWINSMLVGMVDGNDPDSMKPLIDGGTEGFKGQAKVIFPTMTSCIECQLDMHAPRAAVPLCTLATIPRQPQHCIEWAHIIAWEEERKEITLDTDDPEHITWLFQKALKRAEEFNIPGVTYSMTQGVVKNIIPAIASTNAIVAASCCNEAFKILTNANPFLGFPGTDGYMMYTGDESVYTYTFEYEKKEDCPVCGEDALARPLQIDPEATLQEFVDSLAERPEAQLKTPSIRTTEKSLYIQSAADYERMTRPNLEKKMKDLTAEGEEMLISDKAFPMMFKFSVVWKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CNM8</accession>
    <name>A0A177CNM8_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glucosamine-6-phosphate isomerase</fullName>
            <ecNumber evidence="6">3.5.99.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Glucosamine-6-phosphate isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_580563</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the reversible conversion of alpha-D-glucosamine 6-phosphate (GlcN-6P) into beta-D-fructose 6-phosphate (Fru-6P) and ammonium ion, a regulatory reaction step in de novo uridine diphosphate-N-acetyl-alpha-D-glucosamine (UDP-GlcNAc) biosynthesis via hexosamine pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>alpha-D-glucosamine 6-phosphate + H2O = beta-D-fructose 6-phosphate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:12172"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:75989"/>
            <dbReference type="EC" id="3.5.99.6"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the glucosamine/galactosamine-6-phosphate isomerase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.99.6" evidence="6"/>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038865.1">
        <property type="nucleotide sequence ID" value="XM_018186751.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CNM8"/>
    <dbReference type="STRING" id="1460663.A0A177CNM8"/>
    <dbReference type="GeneID" id="28770237"/>
    <dbReference type="InParanoid" id="A0A177CNM8"/>
    <dbReference type="OrthoDB" id="7663298at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004342">
        <property type="term" value="F:glucosamine-6-phosphate deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006043">
        <property type="term" value="P:glucosamine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006046">
        <property type="term" value="P:N-acetylglucosamine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019262">
        <property type="term" value="P:N-acetylneuraminate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01399">
        <property type="entry name" value="GlcN6P_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1360:FF:000002">
        <property type="entry name" value="Glucosamine-6-phosphate deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01241">
        <property type="entry name" value="GlcN6P_deamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006148">
        <property type="entry name" value="Glc/Gal-6P_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004547">
        <property type="entry name" value="Glucosamine6P_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018321">
        <property type="entry name" value="Glucosamine6P_isomerase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00502">
        <property type="entry name" value="nagB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11280">
        <property type="entry name" value="GLUCOSAMINE-6-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11280:SF5">
        <property type="entry name" value="GLUCOSAMINE-6-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01182">
        <property type="entry name" value="Glucosamine_iso"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01161">
        <property type="entry name" value="GLC_GALNAC_ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucosamine/galactosamine-6-phosphate isomerase" evidence="7">
        <location>
            <begin position="11"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAG08500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="349" mass="38854" checksum="B6784E942E17372A" modified="2016-09-07" version="1">MRLIIRDDPGTASKYIADYIIERIKTFNPSQERPFVLGLPTGSSPVLIYQYLVQRHKAGEISFRNVVTFNMDEYVGIPREHPESYHSFMYKHFFSHVDVRPENINILNGNAPDLEAECHAYEEKIANAGGIELFLGGIGPDGHVAFNEPGSSLKSRTRVKTLAYDTILANSRFFGNDLDQVPRMALTVGVRTVLDAREVVIIITGAHKALALQKCIEEGINHMWTLSSLQLHPHPMIVTDEDATLELKVKTVRYFKSIEKVATEQGFRQMLPRIKKRDSVHETDGLLPAPQPQRNGLTLAVPPQDISRSASPALEPMSARISDSEASALRAVDLNSELQFAPMSARVAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CNU2</accession>
    <name>A0A177CNU2_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA2/NAM7 helicase-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1215334</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039236.1">
        <property type="nucleotide sequence ID" value="XM_018182713.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CNU2"/>
    <dbReference type="GeneID" id="28766199"/>
    <dbReference type="InParanoid" id="A0A177CNU2"/>
    <dbReference type="OrthoDB" id="3689346at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG08871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="209" mass="23144" checksum="8964DDD52088CE73" modified="2016-09-07" version="1">MSDDTRKTMKATFKVGFWHVVGRAPALCTTPAATASSGFQVHRRAVTYCLEEAGRAPDLEIMGMCSKSGTSTAVGDRRQLGPQAYSSQLDKLFLRNTRHLRWFQNAALLELCQRLHDAEGIRENPGALNNVTKHRAKSTSLRIRGIRSTIVVLNIEDVAPTRDATGSCYCVETSLTTMHDLINRLRHVSGDDIMIVTPYNARVRLLGAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CNU3</accession>
    <name>A0A177CNU3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Copper-fist domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CC84DRAFT_1257426</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038953.1">
        <property type="nucleotide sequence ID" value="XM_018184730.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CNU3"/>
    <dbReference type="STRING" id="1460663.A0A177CNU3"/>
    <dbReference type="GeneID" id="28768216"/>
    <dbReference type="InParanoid" id="A0A177CNU3"/>
    <dbReference type="OrthoDB" id="5600085at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006878">
        <property type="term" value="P:intracellular copper ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.430.10:FF:000001">
        <property type="entry name" value="Copper fist DNA-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.430.10">
        <property type="entry name" value="Copper fist DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051763">
        <property type="entry name" value="Copper_Homeo_Regul"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001083">
        <property type="entry name" value="Cu_fist_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036395">
        <property type="entry name" value="Cu_fist_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28088:SF9">
        <property type="entry name" value="TRANSCRIPTION FACTOR GRISEA, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G13190)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28088">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR HAA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00649">
        <property type="entry name" value="Copper-fist"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00617">
        <property type="entry name" value="COPPERFIST"/>
    </dbReference>
    <dbReference type="SMART" id="SM01090">
        <property type="entry name" value="Copper-fist"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00412">
        <property type="entry name" value="Cu_FIST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57879">
        <property type="entry name" value="Zinc domain conserved in yeast copper-regulated transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50073">
        <property type="entry name" value="COPPER_FIST_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Copper-fist" evidence="9">
        <location>
            <begin position="11"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="113"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="160"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="189"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="425"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="128"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="160"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="449"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAG08588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="548" mass="58252" checksum="A51CF8167FD3FA46" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CP39</accession>
    <name>A0A177CP39_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Tat pathway signal sequence</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1255363</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Mycotoxin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ustYa family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG09274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039639.1">
        <property type="nucleotide sequence ID" value="XM_018184533.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CP39"/>
    <dbReference type="STRING" id="1460663.A0A177CP39"/>
    <dbReference type="GeneID" id="28768019"/>
    <dbReference type="InParanoid" id="A0A177CP39"/>
    <dbReference type="OrthoDB" id="3769434at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021765">
        <property type="entry name" value="UstYa-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365:SF4">
        <property type="entry name" value="CYCLOCHLOROTINE BIOSYNTHESIS PROTEIN O"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365">
        <property type="entry name" value="YALI0B05434P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11807">
        <property type="entry name" value="UstYa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00035112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG09274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="179" mass="20534" checksum="CACA3CFDC74B1B58" modified="2016-09-07" version="1">MAKQPPAEDVIEYKTVEFVTNLHADMAHAEKNIYLELTDEGDAAWDLLTETYATSAIAPSLAQRLNEPTSPSPNEPDRYLVGLSVFHQLHCLSRIRRLLHPDRYPRSYFNLSAAETAVHDAHCVDLIRQTLMCHADISPVTWEWNERMGMALPSAKTMHVCRRWEPIWEWAVEHRAVGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CPE0</accession>
    <name>A0A177CPE0_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RmlC-like cupin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CC84DRAFT_1085162</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="2">Binds 1 Fe cation per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the pirin family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG09081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039446.1">
        <property type="nucleotide sequence ID" value="XM_018174088.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CPE0"/>
    <dbReference type="STRING" id="1460663.A0A177CPE0"/>
    <dbReference type="GeneID" id="28757574"/>
    <dbReference type="InParanoid" id="A0A177CPE0"/>
    <dbReference type="OrthoDB" id="198735at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02247">
        <property type="entry name" value="cupin_pirin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02909">
        <property type="entry name" value="cupin_pirin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012093">
        <property type="entry name" value="Pirin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008778">
        <property type="entry name" value="Pirin_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003829">
        <property type="entry name" value="Pirin_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13903:SF8">
        <property type="entry name" value="PIRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13903">
        <property type="entry name" value="PIRIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02678">
        <property type="entry name" value="Pirin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05726">
        <property type="entry name" value="Pirin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006232">
        <property type="entry name" value="Pirin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pirin N-terminal" evidence="4">
        <location>
            <begin position="41"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="Pirin C-terminal" evidence="5">
        <location>
            <begin position="196"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR006232-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAG09081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="321" mass="35243" checksum="3C33C4FE37931526" modified="2016-09-07" version="1">MTTNTTFKGLPVIPDEPLTTTAPRKIQKSFLAIEQSEGAGARVRRSIGTPQLRNFSPFLMLDHFSVPPGAGFPDHPHRGQETITYLLSGALDHEDFAGHAGSIEAGDLQFMTAGRGIVHAEMPRQNEDGSPNVGMQLWVDLPKELKSCEPRYRDLRAKEIPEATGDNGKVKVKVISGRAYDTDSLKELAYTPVWLLDFTVQPGGHVKQALPKGWNAFAYLLNGTTIFSSEGVSRPVPQYHNVVFGTAGDSIEATVEEGAETASRFILVAGMPLDQPIVQYGPFVVTSRDEVVQAMTDYQTHSNGFERAYNWESEIGKNMVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CPS7</accession>
    <name>A0A177CPS7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 8">Multifunctional fusion protein</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="8">Delta-1-pyrroline-5-carboxylate dehydrogenase</fullName>
                <shortName evidence="8">P5C dehydrogenase</shortName>
            </recommendedName>
            <alternativeName>
                <fullName evidence="8">L-glutamate gamma-semialdehyde dehydrogenase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="7">L-glutamate gamma-semialdehyde dehydrogenase</fullName>
                <ecNumber evidence="7">1.2.1.88</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CC84DRAFT_1110443</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>L-glutamate 5-semialdehyde + NAD(+) + H2O = L-glutamate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:30235"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58066"/>
            <dbReference type="EC" id="1.2.1.88"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 7">Amino-acid degradation; L-proline degradation into L-glutamate; L-glutamate from L-proline: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.88" evidence="7"/>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG09231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039596.1">
        <property type="nucleotide sequence ID" value="XM_018175253.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CPS7"/>
    <dbReference type="STRING" id="1460663.A0A177CPS7"/>
    <dbReference type="GeneID" id="28758739"/>
    <dbReference type="InParanoid" id="A0A177CPS7"/>
    <dbReference type="OrthoDB" id="5322683at2759"/>
    <dbReference type="UniPathway" id="UPA00261">
        <property type="reaction ID" value="UER00374"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003842">
        <property type="term" value="F:L-glutamate gamma-semialdehyde dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010133">
        <property type="term" value="P:L-proline catabolic process to L-glutamate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000006">
        <property type="entry name" value="1-pyrroline-5-carboxylate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000005">
        <property type="entry name" value="1-pyrroline-5-carboxylate dehydrogenase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005931">
        <property type="entry name" value="P5CDH/ALDH4A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050485">
        <property type="entry name" value="Proline_metab_enzyme"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01236">
        <property type="entry name" value="D1pyr5carbox1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42862">
        <property type="entry name" value="DELTA-1-PYRROLINE-5-CARBOXYLATE DEHYDROGENASE 1, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42862:SF1">
        <property type="entry name" value="DELTA-1-PYRROLINE-5-CARBOXYLATE DEHYDROGENASE 2, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0520">NAD</keyword>
    <keyword evidence="3 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5 7" id="KW-0642">Proline metabolism</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="10">
        <location>
            <begin position="86"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="31"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU366016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OAG09231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="579" mass="64018" checksum="10D3C670A520B266" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CPV4</accession>
    <name>A0A177CPV4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_587625</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039174.1">
        <property type="nucleotide sequence ID" value="XM_018186794.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CPV4"/>
    <dbReference type="GeneID" id="28770280"/>
    <dbReference type="InParanoid" id="A0A177CPV4"/>
    <dbReference type="OrthoDB" id="3791893at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="67"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG08809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="200" mass="21922" checksum="ED691534B7F688FD" modified="2016-09-07" version="1">MTLPGLQSRAASLTLSATFQPPHTHTQRHEDSLLKVPASNTDALPPHLHGATHGDVLSEATRHNKHTPPTSSIDPSPDSNLYPMSSQSSIAQLDGPQDHRPRTHIYTLPPSLMTPQLHGKANNQPPKSAYRDLLPYCTVDTPLTEQQVVRLSDIAGSLREVVALAVRARTNERARAVLREALGEGVARGVVEFWEEEFEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CQD6</accession>
    <name>A0A177CQD6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">L-lactate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CC84DRAFT_1193433</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the cytochrome b5 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG09733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040098.1">
        <property type="nucleotide sequence ID" value="XM_018181296.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CQD6"/>
    <dbReference type="STRING" id="1460663.A0A177CQD6"/>
    <dbReference type="GeneID" id="28764782"/>
    <dbReference type="InParanoid" id="A0A177CQD6"/>
    <dbReference type="OrthoDB" id="1925334at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02922">
        <property type="entry name" value="FCB2_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000262">
        <property type="entry name" value="FMN-dep_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037396">
        <property type="entry name" value="FMN_HAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008259">
        <property type="entry name" value="FMN_hydac_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037458">
        <property type="entry name" value="L-MDH/L-LDH_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578:SF104">
        <property type="entry name" value="CYTOCHROME B2, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578">
        <property type="entry name" value="S -2-HYDROXY-ACID OXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01070">
        <property type="entry name" value="FMN_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00363">
        <property type="entry name" value="CYTOCHROMEB5"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00557">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51349">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0349">Heme</keyword>
    <keyword evidence="5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="7">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="FMN hydroxy acid dehydrogenase" evidence="8">
        <location>
            <begin position="105"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAG09733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="500" mass="54924" checksum="32A0B286E4EA733B" modified="2016-09-07" version="1">MAAVDGAEVAQHDNRKSCWIVLDSKVYDVTKFLSKHPGGAAIILKNAGTDATEEFKKYHPLDYVKDLSEGSIVGPINPDTLGRLREKKEVNAAPADSANTDREIPHLTMCVSCPDFERAARAVLPHKSFVYASTSANTGLSLKTNLDDWGRINFRPRVMRNVGDVDSRRSIFGHTSQYPFYISPMGTLGAIHPEAEPEMVRGAVRKGAHMVVSTASTKTSQQIMQAYIDEQTRLNNKSPTQLFYQYYMPVDRKKAIELMHIVKKSGYKGIWITVDTPVLGKRTADRVLQAEEALAVGLDEEGTAEWEAGGENAFAPAMGGRVVSGQLSPHTTWEDLAWIRKEWEGPIVLKGIQTADDAKLAYEYGCDGILLSNHGGRQLHTAPSALMTLLEIRTYCPEIIGKLEIFLDGGLRDGSDVLKALCLGATAVGVGRPFMYALAAYGSQGVERCIDVLAEELTLGMRLLGVTALDQLKPEMVNASRLLNEMWRPESNSISIKSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CQS9</accession>
    <name>A0A177CQS9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_433643</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG09302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039667.1">
        <property type="nucleotide sequence ID" value="XM_018186242.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CQS9"/>
    <dbReference type="STRING" id="1460663.A0A177CQS9"/>
    <dbReference type="GeneID" id="28769728"/>
    <dbReference type="InParanoid" id="A0A177CQS9"/>
    <dbReference type="OrthoDB" id="2520703at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG09302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="512" mass="58648" checksum="85369F5A230A1A3D" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CR96</accession>
    <name>A0A177CR96_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CC84DRAFT_1255466</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG09410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039775.1">
        <property type="nucleotide sequence ID" value="XM_018184541.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CR96"/>
    <dbReference type="GeneID" id="28768027"/>
    <dbReference type="InParanoid" id="A0A177CR96"/>
    <dbReference type="OrthoDB" id="3639251at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:001516">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF49">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G04250)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="118"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="177"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="210"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="281"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="320"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="344"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="370"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="406"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="438"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAG09410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="483" mass="53142" checksum="99F50E2EDB5BF7D5" modified="2016-09-07" version="1">MSGHENAAQDKDLEKLKGNDHVDALEDYFDPVATKALVWKQDLRIVPLAAAIYLLCYLDRSNIGNAKTLNASQNESLLQLTHMTNYQYTIALMVFLVAYAVFEVPSNYFLKKCKPSRWIAFLMFSWGACTIGLGGAQNYATVTAVRFLLGMFEAGLFPGLVYYLTFWYRSEERSMRVAIILASATLAGAFGGAIAYGVGHMRLVSGLASWRWLFILEGIPSCISSVAVWFFLPDYPEEAKWLTTAERELAVARLEKEGSKGNAPSLTWETAKETILEGRLWIHYIIYFGISAPFSSLSLFTPTITAGLGYENLQAQLMTIPPYAVAYVVSIATAWSSDHFNARALHSAVLSTIGAIGFLASALLPADSYHARYGCLIVAASGAFSCIPPLLGWLSSNMHTTAGAGLAIALNVSWGAPGQILGVWIYKADEKEKGYPTGHWTNFAMLLMVAVGCVGMRFYYQWRNRKIKSLGPDASGVTREFSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CSF9</accession>
    <name>A0A177CSF9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Kinase</fullName>
            <ecNumber evidence="4">2.7.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CC84DRAFT_1160794</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the inositol phosphokinase (IPK) family.</text>
    </comment>
    <dbReference type="EC" id="2.7.-.-" evidence="4"/>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG09689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040054.1">
        <property type="nucleotide sequence ID" value="XM_018177582.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CSF9"/>
    <dbReference type="FunCoup" id="A0A177CSF9">
        <property type="interactions" value="57"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CSF9"/>
    <dbReference type="GeneID" id="28761068"/>
    <dbReference type="InParanoid" id="A0A177CSF9"/>
    <dbReference type="OrthoDB" id="338650at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000824">
        <property type="term" value="F:inositol-1,4,5,6-tetrakisphosphate 3-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008440">
        <property type="term" value="F:inositol-1,4,5-trisphosphate 3-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032958">
        <property type="term" value="P:inositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.160">
        <property type="entry name" value="Inositol polyphosphate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005522">
        <property type="entry name" value="IPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038286">
        <property type="entry name" value="IPK_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12400">
        <property type="entry name" value="INOSITOL POLYPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12400:SF103">
        <property type="entry name" value="INOSITOL POLYPHOSPHATE MULTIKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03770">
        <property type="entry name" value="IPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56104">
        <property type="entry name" value="SAICAR synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAG09689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="343" mass="37266" checksum="276D76FAB3D29858" modified="2016-09-07" version="1">MSKKPFDPSTLQAFGNAAAGHDGVLSDLSGAVVVKPCTAAEIAFYESISASHPDLAPHLPTFMGQLSLSSDQSGSAPVAIEESGTIVTADGVVERLHGKKLDTELHIVLENITHGFTKPNVLDLKLGAQLWDEGAKPEKRARLDKVSAETTSGSLGFRIAGMRVYKGEPVPGTPEGLKEFVEADYEKGYWVYNKMYGRKFAAEDINEGFENYIHGQGKQGKELERAREVLAYFLGEAKDIIRAFEKKESRMYSASILLVYEGDVDAYARAKERLRSAPAGEEGDEEDDLPQLAAVKMIDFAHATWAPGQGPDENALRGMRSTTSILKDLLDSVEKELDAAEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2023-06-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CTG5</accession>
    <name>A0A177CTG5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1173160</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041188.1">
        <property type="nucleotide sequence ID" value="XM_018180011.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CTG5"/>
    <dbReference type="GeneID" id="28763497"/>
    <dbReference type="InParanoid" id="A0A177CTG5"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG10823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="158" mass="16867" checksum="7C19B286728DEA54" modified="2016-09-07" version="1">MAGGEPDTPFWAIAHPPTVNDAVGVDCRMCRWIGSRGAGRVPTNVVAMWPRPEVCKRRRLRGGSKPEAGRQRLPRARVRRAILSSSRCLRLAATAGEQCALGRAAVQRVGSGRSCGRAKRSAAAWRHKTAPQGIPTTALHALRVSEPPGQASACLCPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CTW1</accession>
    <name>A0A177CTW1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CC84DRAFT_1193833</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="3"/>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040717.1">
        <property type="nucleotide sequence ID" value="XM_018181326.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CTW1"/>
    <dbReference type="STRING" id="1460663.A0A177CTW1"/>
    <dbReference type="GeneID" id="28764812"/>
    <dbReference type="InParanoid" id="A0A177CTW1"/>
    <dbReference type="OrthoDB" id="5357315at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04813">
        <property type="entry name" value="PA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16454">
        <property type="entry name" value="RING-H2_PA-TM-RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000364">
        <property type="entry name" value="Protease-associated PA domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051653">
        <property type="entry name" value="E3_ligase_sorting_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046450">
        <property type="entry name" value="PA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003137">
        <property type="entry name" value="PA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47168:SF1">
        <property type="entry name" value="OS02G0798600 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47168">
        <property type="entry name" value="RING ZINC FINGER DOMAIN SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02225">
        <property type="entry name" value="PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52025">
        <property type="entry name" value="PA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="475"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="13">
        <location>
            <begin position="599"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="106"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="342"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="397"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="430"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="521"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="680"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="133"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="355"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="409"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="525"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="680"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="702"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="714"/>
            <end position="725"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OAG10352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="768" mass="83213" checksum="24E261C1F2C1EE4F" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CTW7</accession>
    <name>A0A177CTW7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CC84DRAFT_1113637</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PIGG/PIGN/PIGO family. PIGO subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041329.1">
        <property type="nucleotide sequence ID" value="XM_018175362.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CTW7"/>
    <dbReference type="FunCoup" id="A0A177CTW7">
        <property type="interactions" value="659"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CTW7"/>
    <dbReference type="GeneID" id="28758848"/>
    <dbReference type="InParanoid" id="A0A177CTW7"/>
    <dbReference type="OrthoDB" id="272139at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051377">
        <property type="term" value="F:mannose-ethanolamine phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16023">
        <property type="entry name" value="GPI_EPT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002591">
        <property type="entry name" value="Phosphodiest/P_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037675">
        <property type="entry name" value="PIG-O_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039524">
        <property type="entry name" value="PIGO/GPI13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23071:SF1">
        <property type="entry name" value="GPI ETHANOLAMINE PHOSPHATE TRANSFERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23071">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL GLYCAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01663">
        <property type="entry name" value="Phosphodiest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="507"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="539"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="569"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="601"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="629"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="658"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="699"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="732"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="774"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="927"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="970"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1000"/>
            <end position="1021"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="18"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OAG10964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="1038" mass="113819" checksum="32BDE3B61738562A" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CUJ8</accession>
    <name>A0A177CUJ8_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_1161732</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041281.1">
        <property type="nucleotide sequence ID" value="XM_018177821.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CUJ8"/>
    <dbReference type="GeneID" id="28761307"/>
    <dbReference type="InParanoid" id="A0A177CUJ8"/>
    <dbReference type="OrthoDB" id="3795469at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF47">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="37"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="99"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="128"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="26"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAG10916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="203" mass="23406" checksum="78E7F13C03097A43" modified="2016-09-07" version="1">METLQPNVGAAISITYSAALIAFLSRFFARKWNGVPFIAGDWVSAVAFFFVTAYNILFLIKLKFGLGLRRENIALRKHDGSINYDSMAHEYFFFLYPDMWLYTAAMGMSKMTALALQWRLFGKSATRYWILLLVGCVVWWMFARCVVILAVCTPISHFWNRQEPGHCRINLTQFFYSTTDSSPRFRSVYRSATLVRDPKAEEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CUX6</accession>
    <name>A0A177CUX6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1133055</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG11354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041719.1">
        <property type="nucleotide sequence ID" value="XM_018175960.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CUX6"/>
    <dbReference type="GeneID" id="28759446"/>
    <dbReference type="InParanoid" id="A0A177CUX6"/>
    <dbReference type="OrthoDB" id="3913028at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG11354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="175" mass="19591" checksum="AB336E4E2691456B" modified="2016-09-07" version="1">MPDMATWKSNSTGGSSQTSKASALFGLDEDDKTNILVYRYRSGCKALEVSTQHDLCRELDNDPQLPFMRVTKKEIPRGNSRLEIRTEDLLLPEDLERNRDKPTLKSSLANVGLPSTAYWKRLLFNSFPELYIVHRSPTTSPASSKNNSPENSQHVSPATTFPVDTPHPSQDPTES</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CV65</accession>
    <name>A0A177CV65_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Unsaturated glucuronyl hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1084094</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 88 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041125.1">
        <property type="nucleotide sequence ID" value="XM_018174033.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CV65"/>
    <dbReference type="GeneID" id="28757519"/>
    <dbReference type="InParanoid" id="A0A177CV65"/>
    <dbReference type="OrthoDB" id="2317065at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052757">
        <property type="term" value="F:chondroitin hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010905">
        <property type="entry name" value="Glyco_hydro_88"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052369">
        <property type="entry name" value="UG_Glycosaminoglycan_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36845">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G05090)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36845:SF1">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G05090)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07470">
        <property type="entry name" value="Glyco_hydro_88"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG10760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="448" mass="50299" checksum="9565C61C49078E87" modified="2016-09-07" version="1">MAKSSRSNPLDKYLLNLYTPSVEAKIWSIAAKGLQQSSPPTLYPEYTKPGGTHYIYRKADFWTSGFFPGSLYLLLERKKKHSHVLGQAGDLWAGNLHPLSLEFACKYWTESLHSNALLSNTHDLGFMIMPWAKVAYELNHDLRALDTIERAAQTLFSRYNSSMGCIRSWDNCVTKKYSFQDVNSEFMVIIDNMMNLDLLFYAASKTGNADMFSAAVQHARTTSRTHIRADGSTTHLVVLDPRSGDIRHRLTNQGHSHSSCWARGQAWAIAGFAETYHWTHDEDFLHISQRVANYFIEHLPDSGIVPWDFDAIEHETTSQPSDSSAAMVAAYGMLLIHEGLVHLGQSSNYLREALKLTRAVCAYQMNPEASWVVSEIVMDTVECGSVKKTAQEASVGIGDTILTGATINNYEYAPRRWANHGLVYADYYFLLVGNKMLEMGIDLCGILV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CWD5</accession>
    <name>A0A177CWD5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Metallo-hydrolase/oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_1210851</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>(3R)-atrochrysone 2-carbonyl-[ACP] + H2O = (3R)-atrochrysone 2-carboxylate + holo-[ACP] + H(+)</text>
            <dbReference type="Rhea" id="RHEA:64236"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:20479"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:234107"/>
            <dbReference type="ChEBI" id="CHEBI:234110"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:64237"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG11180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041545.1">
        <property type="nucleotide sequence ID" value="XM_018182327.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CWD5"/>
    <dbReference type="STRING" id="1460663.A0A177CWD5"/>
    <dbReference type="GeneID" id="28765813"/>
    <dbReference type="InParanoid" id="A0A177CWD5"/>
    <dbReference type="OrthoDB" id="17458at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07722">
        <property type="entry name" value="LACTB2-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000328">
        <property type="entry name" value="Lactamase beta 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.15.10:FF:000041">
        <property type="entry name" value="Metallo-beta-lactamase domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047921">
        <property type="entry name" value="LACTB2-like_MBL-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041516">
        <property type="entry name" value="LACTB2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050662">
        <property type="entry name" value="Sec-metab_biosynth-thioest"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23131">
        <property type="entry name" value="ENDORIBONUCLEASE LACTB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23131:SF0">
        <property type="entry name" value="ENDORIBONUCLEASE LACTB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17778">
        <property type="entry name" value="WHD_BLACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="7">
        <location>
            <begin position="33"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00050605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAG11180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="280" mass="30644" checksum="AA06E0743A567C9F" modified="2016-09-07" version="1">MVEPLADLPKVEKLSSRVIRVLGGNPSKFTLQGTNTYIVGSGARRILIDTGEGKPEWLASLKRVLADERITLSHALISHWHHDHTQGVPDLLAVSPSTAVHKRDPQPGWHDITDGQTFTADGATLRAYFCPGHTNDHMAFVLEEEDAMFTADNVLGQGTAVFEDLAVYMTSLEGMATQFTGRAYPGHGPVISDGPAKVREYIAHRRQREKQVLDVLGSEAREGGWTAMEIVKVIYKNYPESLWEPAKAGVLQILRKLEGEGKVVREGEGWKVGGSGKAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CWG5</accession>
    <name>A0A177CWG5_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phytanoyl-CoA dioxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1079101</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG11551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041916.1">
        <property type="nucleotide sequence ID" value="XM_018173825.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CWG5"/>
    <dbReference type="GeneID" id="28757311"/>
    <dbReference type="InParanoid" id="A0A177CWG5"/>
    <dbReference type="OrthoDB" id="445007at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31630:SF7">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31630">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG11551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="340" mass="38592" checksum="2FE403B9D615467A" modified="2016-09-07" version="1">MTTAEPALTLTATAPVERRLQIDGSDPAYGDWRDNLVRDGYAIIKGAVPAEKVEGYADRMYSLLEGFGLGYDRNDPSTVHPDKLPVINEKGMLFTYAACHEDFVWDIRSEPRIIEAFEKVYQDKDLIVSFDAINYGFANRTNLPKNTPWPHQDQDPEKPGFRCLQGLVNLHNAGPKDGGLIVCKGSHLLSEAFHKDMKDEERIPAWTPEWYGYTDAGMKWLEEHGCAWYKVEAEAGDLIVWDSRTAHYNVPTTSDVDRLAIYTCYMPVAEATQEELLRKKGAFDNRVGTTHWPNARNVGWNEAKRNGVLDTIQRNRPWKEPQLSERAFKLTGIPYIKAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CWM6</accession>
    <name>A0A177CWM6_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SPIN90/Ldb17 leucine-rich domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1158758</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG11139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041504.1">
        <property type="nucleotide sequence ID" value="XM_018177065.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CWM6"/>
    <dbReference type="FunCoup" id="A0A177CWM6">
        <property type="interactions" value="10"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CWM6"/>
    <dbReference type="GeneID" id="28760551"/>
    <dbReference type="InParanoid" id="A0A177CWM6"/>
    <dbReference type="OrthoDB" id="445362at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071933">
        <property type="term" value="F:Arp2/3 complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000147">
        <property type="term" value="P:actin cortical patch assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051666">
        <property type="term" value="P:actin cortical patch localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030125">
        <property type="entry name" value="SPIN90/Ldb17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018556">
        <property type="entry name" value="SPIN90/Ldb17_LRD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13357:SF1">
        <property type="entry name" value="NCK-INTERACTING PROTEIN WITH SH3 DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13357">
        <property type="entry name" value="SH3 ADAPTER PROTEIN SPIN90 NCK INTERACTING PROTEIN WITH SH3 DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09431">
        <property type="entry name" value="SPIN90_LRD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SPIN90/Ldb17 leucine-rich" evidence="2">
        <location>
            <begin position="205"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="386"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="387"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG11139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="459" mass="51869" checksum="1017226E900001C0" modified="2016-09-07" version="1">MSSSSGTVRRPLRRTPPCNACTQHAVLTRCATELDDIVSTRCQPHDHEIIDNALRSYLNVTTSYQTEYLQTEYSLAKCVYRLIQGELFTQHKAYVRRQIIYCLLQEDDNPTLHMVAAFLLFDGRNDQNDATFEMMHEEGVFARLIELIQLESVQEEPRLHQMLLELLYESSRIQRLKWEDFVAVDDSFILYLLGVIEGVSDDHEDPYHYPVIRVLLVLNEQYLVASTQSQDGRVTNRVIKALSTHGNIYKTFGCNLILLLNRESETSLQLLILKALYLIFGNPQTAEYFYTNDLHVLVDVILRNLMDLPSDSPAANALRHTYLRVLHPILTHSQISKPPHYKRGDIHQILTLLIASGNHFAPVDETTKRLVNRCTAVPWLKPPVITRTDTSETNGSDSAVQSPVESAVGDGQKEIARRMLGMSVEGGEASSTSVLEVASHTEKPGVLTPSRLKDKEEGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CWV9</accession>
    <name>A0A177CWV9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_42433</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG11691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042056.1">
        <property type="nucleotide sequence ID" value="XM_018186174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CWV9"/>
    <dbReference type="GeneID" id="28769660"/>
    <dbReference type="InParanoid" id="A0A177CWV9"/>
    <dbReference type="OrthoDB" id="3799784at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG11691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="159" mass="17389" checksum="EE7B70E786446047" modified="2016-09-07" version="1">MAVTQDIEATRADEDVPSTPPASALPTYEEARLSSPEPQYEEPLYTEINIPLPPLPKPKAHAAPTGKRPKSHSISSFRPFHRRGSSSESTRKSGDEWPRIKKEVKSREVAAAMNLVGRHHRSGTVDALAVVPAVLVLSAELFTPGIEKSKSGKWEEGMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CXC5</accession>
    <name>A0A177CXC5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">FAD/NAD(P)-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CC84DRAFT_1182490</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG11552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041917.1">
        <property type="nucleotide sequence ID" value="XM_018180637.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CXC5"/>
    <dbReference type="STRING" id="1460663.A0A177CXC5"/>
    <dbReference type="GeneID" id="28764123"/>
    <dbReference type="InParanoid" id="A0A177CXC5"/>
    <dbReference type="OrthoDB" id="9993796at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050493">
        <property type="entry name" value="FAD-dep_Monooxygenase_BioMet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789:SF314">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="6"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAG11552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="422" mass="46727" checksum="3F020BD3945FD00B" modified="2016-09-07" version="1">MSSTFIVVGGGIAGLASAIALRAPKRRIVVLEQSSLNREVGATLSLQPNATKIVEKQWGMGDALKRVGAMRDEGFNMYSIDGKLQRSIPLVSKTEYGADRMVYHRRDIHDTLKEFATQVDGFGEPAEIRTSSCVVACDLDEGIVTLKDGSVIKGDVIIGADGIKSTLRKDVLGYEVQAEPTGFSAYRLVLPSSDLEQNKDFRDVIDPRSSFTSMVMGHDRRMIMGPARDGNLFSVVALVPDQRAEVEAGNSWTSRGDLETLLNEYKDFPAWATAPFRLAKDEIGLWQLRDTEPLETWHRGRVILIGDAAHAMLPTQGQGASQAIEDAEALGAFFSDLKGDIQLEEVQSRFKKIFEARFERATMIQRYSREAARPATDKGDTKIKMNPAEFMDYNCLYNGAKDWAHRRVGTESLEKELQALAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CXR1</accession>
    <name>A0A177CXR1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CC84DRAFT_1159686</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042719.1">
        <property type="nucleotide sequence ID" value="XM_018177296.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CXR1"/>
    <dbReference type="GeneID" id="28760782"/>
    <dbReference type="InParanoid" id="A0A177CXR1"/>
    <dbReference type="OrthoDB" id="196103at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010291">
        <property type="entry name" value="Ion_channel_UNC-93"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051617">
        <property type="entry name" value="UNC-93-like_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23294:SF19">
        <property type="entry name" value="DUF895 DOMAIN MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23294">
        <property type="entry name" value="ET TRANSLATION PRODUCT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05978">
        <property type="entry name" value="UNC-93"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="73"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="130"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="167"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="200"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="259"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="289"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="322"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="424"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAG12354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="476" mass="52482" checksum="8033F6390421AF8C" modified="2016-09-07" version="1">MTEAIKRLSIAEEDHGSAPSDVQGEGEAPQDERYKWYRGVFAQATIVGCCAFAAPGLWNAMQSVGAGGAQTPYLVMAGNAVLFSLMTFACLSGSVVINHIGLRHTLALGTTGYVLYSAALYQNNRYGTEWFIYLGSAACGVTAGLFWAAEGAIMLSYPPPESRGRYLAYWLTYRNSGAILGGIINLAFNYSGRRLGKLNWKTYIVFVVLQCLGPAVAMLLSTPEQVRRRNGTRVKLLPRIPAKIELRETLKLFQRKEMLLLIPYFLYVTWSLPYIGSYMSLYFSVRSRALASLVTALAQVLATAIMGTFLDYKRLSINTRARYGFLGMMVLSGGVWTWALVIQHKYGKHKPALDWKDSAFGEGWALYVFQQVEFALTYNYGYWLISFLARDAVDVVRYSSVARAVEAAGQCVASGISSTQARPIISAGIIFAWWGIALPLGYLVTRQVGIVHVGAERVVTQVREATGDEDAESQKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CYD4</accession>
    <name>A0A177CYD4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1159598</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042621.1">
        <property type="nucleotide sequence ID" value="XM_018177279.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CYD4"/>
    <dbReference type="STRING" id="1460663.A0A177CYD4"/>
    <dbReference type="GeneID" id="28760765"/>
    <dbReference type="InParanoid" id="A0A177CYD4"/>
    <dbReference type="OrthoDB" id="5404323at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="259"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="311"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="438"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="510"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="58"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="264"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="313"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="438"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="459"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="527"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="586"/>
            <end position="622"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG12256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="638" mass="70440" checksum="AB6DA26EB3F85A54" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CZA1</accession>
    <name>A0A177CZA1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transcription initiation factor TFIID subunit 10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_1135875</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Functions as a component of both the DNA-binding general transcription initiation factor complex TFIID and the transcription coactivator SAGA complex. Binding of TFIID to a promoter (with or without TATA element) is the initial step in pre-initiation complex (PIC) formation. TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modification (histone acetylation by TAF1), facilitation of DNA opening and initiation of transcription. SAGA acts as a general cofactor required for essentially all RNA polymerase II transcription. At the promoters, SAGA is required for transcription pre-initiation complex (PIC) recruitment. It influences RNA polymerase II transcriptional activity through different activities such as TBP interaction (via core/TAF module) and promoter selectivity, interaction with transcription activators (via Tra1/SPT module), and chromatin modification through histone acetylation (via HAT module) and deubiquitination (via DUB module). SAGA preferentially acetylates histones H3 (to form H3K9ac, H3K14ac, H3K18ac and H3K23ac) and H2B and deubiquitinates histone H2B. SAGA interacts with DNA via upstream activating sequences (UASs).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the TAF10 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018043198.1">
        <property type="nucleotide sequence ID" value="XM_018176078.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CZA1"/>
    <dbReference type="FunCoup" id="A0A177CZA1">
        <property type="interactions" value="405"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CZA1"/>
    <dbReference type="GeneID" id="28759564"/>
    <dbReference type="InParanoid" id="A0A177CZA1"/>
    <dbReference type="OrthoDB" id="154356at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990841">
        <property type="term" value="F:promoter-specific chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07982">
        <property type="entry name" value="HFD_TAF10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003923">
        <property type="entry name" value="TAF10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21242">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21242:SF0">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03540">
        <property type="entry name" value="TAF10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017246">
        <property type="entry name" value="TFIID_TAF10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 6" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="138"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="156"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR017246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAG12833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="223" mass="23074" checksum="63A99D12CEBC021C" modified="2016-09-07" version="1">MADNTQPPPNADTEVMDDLDAGVDAEIHPENSQLPDAMNLDGANDTEAPQRNGVAAENPIEARIPAKKDATLREFLSKMDEFAPILPDAVTNYYLTRAGLPPPPQTSPHLARLLALATQKFIADIAADAYQFSRIRASNTTSNNPMGGLAGGAGPQGAAAPGGAQSGKDSSAKAKDLALGAPRAGFGGGGQGGGQGRTVLTMEDLGMAVGEYGVNIKRGEFYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177D0D4</accession>
    <name>A0A177D0D4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GH16 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1077283</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042774.1">
        <property type="nucleotide sequence ID" value="XM_018173746.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177D0D4"/>
    <dbReference type="STRING" id="1460663.A0A177D0D4"/>
    <dbReference type="GeneID" id="28757232"/>
    <dbReference type="InParanoid" id="A0A177D0D4"/>
    <dbReference type="OrthoDB" id="192832at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF24">
        <property type="entry name" value="GLYCOSIDASE C21B10.07-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26113">
        <property type="entry name" value="GH16_XgeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008058829" description="GH16 domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="2">
        <location>
            <begin position="10"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG12409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="326" mass="36489" checksum="D18115FD3BAC10D3" modified="2016-09-07" version="1">MYTSSVLALASFAIPSLAAYQPVWNYNASNFWDNFNFIDSADIFTRGFAQYVGIDEALSSGLAKINNGKVRLGVDSKNTYSATSSGRKSIRLQSWGNFDNGLLVADFAHVPVQGCGMWPAFWVYQGERPITPGAYSEIDILENVNVHTANTHSFYTAEKCTIDIQKGNLVPEKSTNCHWESNGPSSQGCSFNAEDGTFNQPFNDQYKVIALQVESERMRIWHFKKNEVPADLNSANPNPDAWTKTPTVHITPKSCDFHKAFQRFHIIINITFCGSWAGDDFNNTNYAGQCAKRTATNDCKSWVGNHPSDFANTYFEFNSIKLFQRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BV13</accession>
    <name>A0A177BV13_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1222999</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441562">
        <property type="protein sequence ID" value="OAF99313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029679.1">
        <property type="nucleotide sequence ID" value="XM_018183451.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BV13"/>
    <dbReference type="GeneID" id="28766937"/>
    <dbReference type="InParanoid" id="A0A177BV13"/>
    <dbReference type="OrthoDB" id="3793261at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAF99313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="183" mass="19795" checksum="7E79092860651B61" modified="2016-09-07" version="1">MTPLYLVIKTQTTHDAKPNYAATSLVPSGLPFPAAHTPSPFNPIRSHHIARNIPHTTADVTENYDVRISWEHDTSACVSVVASSNDKEAAGIVMHEAVDVFVAEAAAELARGEEHVKRRTKTTYDGEYDLVFAAGMRTGKGGNVGFEMFCVEIAPGVGLRYGVYAGVDRGEEREGVEMGDALF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BV33</accession>
    <name>A0A177BV33_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1264311</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441562">
        <property type="protein sequence ID" value="OAF99333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029699.1">
        <property type="nucleotide sequence ID" value="XM_018185301.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BV33"/>
    <dbReference type="GeneID" id="28768787"/>
    <dbReference type="InParanoid" id="A0A177BV33"/>
    <dbReference type="OrthoDB" id="3599883at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024368">
        <property type="entry name" value="Ecl1/2/3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12855">
        <property type="entry name" value="Ecl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAF99333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="306" mass="33525" checksum="15FBD1FE16CC5152" modified="2016-09-07" version="1">MATHTRQVSHTKRPLPAHARPSKPAPLSKRSSSHGASKKAVPLHKKEEEIEDEDLMATSFLQFCTTCEKQIIVPCNAVLYCSESCRKKDTEKQFIFAPDQSPPLTPFSQLSNFSFEDLHFRDIVPPRSPTQLRSNRSSCAFSDLSSDDNAASGDEKPRQHSDASRYLRHCQLTTYSDAAATIRPRRPHYSRASTSHVNFSAAPSLSHTPASSISYSMPYTPSTRPLPPRTNPSSSSYTHKSIDLVTPLTYASTAPSSPRQYSLKSHAETATSASTIEGEIMYAKTPIASMSPANGSLGRLLASSSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BVU2</accession>
    <name>A0A177BVU2_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">D-xylose 1-dehydrogenase (NADP(+), D-xylono-1,5-lactone-forming)</fullName>
            <ecNumber evidence="3">1.1.1.179</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">D-xylose-NADP dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CC84DRAFT_1169847</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>D-xylose + NADP(+) = D-xylono-1,5-lactone + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22000"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15867"/>
            <dbReference type="ChEBI" id="CHEBI:53455"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.179"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfo/Idh/MocA family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.179" evidence="3"/>
    <dbReference type="EMBL" id="KV441564">
        <property type="protein sequence ID" value="OAF98677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029043.1">
        <property type="nucleotide sequence ID" value="XM_018179768.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BVU2"/>
    <dbReference type="STRING" id="1460663.A0A177BVU2"/>
    <dbReference type="GeneID" id="28763254"/>
    <dbReference type="InParanoid" id="A0A177BVU2"/>
    <dbReference type="OrthoDB" id="2129491at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047837">
        <property type="term" value="F:D-xylose 1-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050984">
        <property type="entry name" value="Gfo/Idh/MocA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055170">
        <property type="entry name" value="GFO_IDH_MocA-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22604:SF115">
        <property type="entry name" value="DIHYDRODIOL DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G07520)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22604">
        <property type="entry name" value="OXIDOREDUCTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22725">
        <property type="entry name" value="GFO_IDH_MocA_C3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="7">
        <location>
            <begin position="32"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="GFO/IDH/MocA-like oxidoreductase" evidence="8">
        <location>
            <begin position="149"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="311"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00042988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF22725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAF98677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="400" mass="43163" checksum="F428291F75747BBE" modified="2016-09-07" version="1">MAAPKTIRWGILATGGIATTFTKDLLVDPATRGVRHLKHTVVAAASSSSPARARDFLKATGAPADAKAYGSYQELVDDANVDIVYVATPHSHHYQNAMLALEAGKPVLCEKAFTVNAAQLRALADKAREKGLFLMEAVWTRYFPLSVYVRDQITAGRIGPVARVFADNSMACDPEVQWKDGTNRMVNPDLAGGALLDLGIYSLTWVFQTLYHTQPPGARQAPKVLAAMKNYGPTKDADETTTIVLSFPRADDAGGEAHAIATTSIRVATSPAGNQDVPGIRIQGPNGEIQVFPPAFRPTRTRIVLKDGTVEDKTWPQPGPGEGSGWHNGFGATTNAEGEGHGMFWEADEAADALINGRKEGRYEGLDESILIMDVMDETRKQGGLTYPDKIETTKYPTQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BW60</accession>
    <name>A0A177BW60_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Thioredoxin reductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1170045</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441566">
        <property type="protein sequence ID" value="OAF98606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018028972.1">
        <property type="nucleotide sequence ID" value="XM_018179823.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BW60"/>
    <dbReference type="GeneID" id="28763309"/>
    <dbReference type="InParanoid" id="A0A177BW60"/>
    <dbReference type="OrthoDB" id="4499271at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAF98606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="239" mass="26764" checksum="53C644E458116E41" modified="2016-09-07" version="1">MAEDVSKGQDDSELPPLDDRLVASAAASLDASKIPYVLWGNYMLTIFGIPTVFNGMDFVVDDDFMDAAYDTLQGAGFKKCKSEGCNGNKKLFYAPTPHTHLHITESERLGLYKRSDILWRLPNLSNVDGESITLASDPNQLPGPDILGRRGRFQQDLHPVRVPTVSQLVQVLLLLAKKDQNTYGGYWINWISYILEFCTENGVFDKSRLTGNYKTYINAFLEGDHTSRDKAFECIGLTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BWQ4</accession>
    <name>A0A177BWQ4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_424178</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441564">
        <property type="protein sequence ID" value="OAF98749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029115.1">
        <property type="nucleotide sequence ID" value="XM_018186171.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BWQ4"/>
    <dbReference type="STRING" id="1460663.A0A177BWQ4"/>
    <dbReference type="GeneID" id="28769657"/>
    <dbReference type="InParanoid" id="A0A177BWQ4"/>
    <dbReference type="OrthoDB" id="2565191at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006360">
        <property type="term" value="P:transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022793">
        <property type="entry name" value="Rrn10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28054">
        <property type="entry name" value="RNA POLYMERASE I-SPECIFIC TRANSCRIPTION INITIATION FACTOR RRN10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28054:SF1">
        <property type="entry name" value="RNA POLYMERASE I-SPECIFIC TRANSCRIPTION INITIATION FACTOR RRN10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAF98749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="172" mass="19420" checksum="C9B77FD42212CEF5" modified="2016-09-07" version="1">MPSETVRSSRSTVYDAVAGRVTQSGVYEPTATEQKRATLRLRPDEVLFKQRRAPPRYEEADYYFAHRKLPSSQALPSSDLLSALHEYIAQLYDCNFSQDRKESGSWKSMDETALIAFGVLLEEAMKATLGERGHLALVEAEGSQEDETFVKNARVKEEEDGRGRRGRGRDIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BX62</accession>
    <name>A0A177BX62_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1222975</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441562">
        <property type="protein sequence ID" value="OAF99281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029647.1">
        <property type="nucleotide sequence ID" value="XM_018183447.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BX62"/>
    <dbReference type="STRING" id="1460663.A0A177BX62"/>
    <dbReference type="GeneID" id="28766933"/>
    <dbReference type="InParanoid" id="A0A177BX62"/>
    <dbReference type="OrthoDB" id="1911848at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37542">
        <property type="entry name" value="HELO DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37542:SF1">
        <property type="entry name" value="PRION-INHIBITION AND PROPAGATION HELO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="211"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="76"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAF99281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="519" mass="58837" checksum="9ACD5EAAA45E3633" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BX72</accession>
    <name>A0A177BX72_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Pinin/SDK/MemA protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CC84DRAFT_1222984</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the pinin family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441562">
        <property type="protein sequence ID" value="OAF99291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029657.1">
        <property type="nucleotide sequence ID" value="XM_018183449.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BX72"/>
    <dbReference type="STRING" id="1460663.A0A177BX72"/>
    <dbReference type="GeneID" id="28766935"/>
    <dbReference type="InParanoid" id="A0A177BX72"/>
    <dbReference type="OrthoDB" id="330772at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039853">
        <property type="entry name" value="Pinin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006786">
        <property type="entry name" value="Pinin_SDK_MemA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12707:SF0">
        <property type="entry name" value="PININ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12707">
        <property type="entry name" value="PINN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04696">
        <property type="entry name" value="Pinin_SDK_memA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Pinin/SDK/MemA protein" evidence="9">
        <location>
            <begin position="71"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="192"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="69"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="98"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="126"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="192"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="246"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="280"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="301"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAF99291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="311" mass="35338" checksum="1B2B9CBCDFCBC2E1" modified="2016-09-07" version="1">MDGIASAVVLPDQDVDSPPPTAASPTGTKRRQSSISEQDAKRVRLNGNGSPTDRRESVSSTKAAATAPKGRERGRERRLFGAALGALSQNSATTGQKRRLEIEKRQRAQRKLEEEESEHRKQERQAKRKAQRWREHRRFEKDSLRIRHDNLLAMAHFLHTRTEPRLYYKPWETTPEEDERIRDQIAEAHDIVQREREDFEAKQRQYAGRERDANRDMHMDGDAEDTRSGKEYSEKAPAEPAAANGHPTNGSETSKNPEQNGDHAQTREGGVTSLEQDSTTGHERSTDDTYKEAMDDHGEEVVEAAEDTVMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BXH0</accession>
    <name>A0A177BXH0_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Extracellular membrane protein CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1222346</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441560">
        <property type="protein sequence ID" value="OAG00015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030380.1">
        <property type="nucleotide sequence ID" value="XM_018183359.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BXH0"/>
    <dbReference type="GeneID" id="28766845"/>
    <dbReference type="InParanoid" id="A0A177BXH0"/>
    <dbReference type="OrthoDB" id="3763898at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008057493" description="Extracellular membrane protein CFEM domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG00015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="82" mass="9117" checksum="8D609A93B1880AB2" modified="2016-09-07" version="1">MKFSVTLATLMVLASRTASTPVEVVAQGECGPKWDWCDNLGEIRCECNGGHRLKCTQIWLDSGVSKSSIFEGRRKVQSLRDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BYB4</accession>
    <name>A0A177BYB4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cytochrome P450 monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CC84DRAFT_1263462</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441559">
        <property type="protein sequence ID" value="OAG00504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030869.1">
        <property type="nucleotide sequence ID" value="XM_018185242.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BYB4"/>
    <dbReference type="STRING" id="1460663.A0A177BYB4"/>
    <dbReference type="GeneID" id="28768728"/>
    <dbReference type="InParanoid" id="A0A177BYB4"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11061">
        <property type="entry name" value="CYP67-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF172">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 4 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="4">
        <location>
            <position position="469"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAG00504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="529" mass="60209" checksum="07DD3D02DE077AF9" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BZZ3</accession>
    <name>A0A177BZZ3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 18">Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial</fullName>
            <ecNumber evidence="5 18">1.3.5.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">CC84DRAFT_1155489</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17 24">
            <text>a quinone + succinate = fumarate + a quinol</text>
            <dbReference type="Rhea" id="RHEA:40523"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.3.5.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="18">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
        <text evidence="18">Binds 1 [2Fe-2S] cluster.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="18">
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </cofactor>
        <text evidence="18">Binds 1 [3Fe-4S] cluster.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="18">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="18">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 18">Carbohydrate metabolism; tricarboxylic acid cycle; fumarate from succinate (eukaryal route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of complex II composed of four subunits: a flavoprotein (FP), an iron-sulfur protein (IP), and a cytochrome b composed of a large and a small subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 18">Mitochondrion inner membrane</location>
            <topology evidence="1 18">Peripheral membrane protein</topology>
            <orientation evidence="1 18">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 18">Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.</text>
    </comment>
    <dbReference type="EC" id="1.3.5.1" evidence="5 18"/>
    <dbReference type="EMBL" id="KV441559">
        <property type="protein sequence ID" value="OAG00561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030926.1">
        <property type="nucleotide sequence ID" value="XM_018176936.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BZZ3"/>
    <dbReference type="FunCoup" id="A0A177BZZ3">
        <property type="interactions" value="690"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177BZZ3"/>
    <dbReference type="GeneID" id="28760422"/>
    <dbReference type="InParanoid" id="A0A177BZZ3"/>
    <dbReference type="OrthoDB" id="1696654at2759"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER01006"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051538">
        <property type="term" value="F:3 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008177">
        <property type="term" value="F:succinate dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022904">
        <property type="term" value="P:respiratory electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.30:FF:000007">
        <property type="entry name" value="Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1060.10:FF:000001">
        <property type="entry name" value="Succinate dehydrogenase iron-sulfur subunit SdhB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="entry name" value="Alpha-helical ferredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050573">
        <property type="entry name" value="SDH/FRD_Iron-Sulfur"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004489">
        <property type="entry name" value="Succ_DH/fum_Rdtase_Fe-S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025192">
        <property type="entry name" value="Succ_DH/fum_Rdtase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00384">
        <property type="entry name" value="dhsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004616">
        <property type="entry name" value="PRK05950.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11921:SF29">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE [UBIQUINONE] IRON-SULFUR SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11921">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE IRON-SULFUR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13085">
        <property type="entry name" value="Fer2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13534">
        <property type="entry name" value="Fer4_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="2Fe-2S ferredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46548">
        <property type="entry name" value="alpha-helical ferredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 18" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="16 18" id="KW-0003">3Fe-4S</keyword>
    <keyword evidence="8 18" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="12" id="KW-0249">Electron transport</keyword>
    <keyword evidence="14 18" id="KW-0408">Iron</keyword>
    <keyword evidence="15 18" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="18" id="KW-0472">Membrane</keyword>
    <keyword evidence="11 18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="18" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <keyword evidence="9" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="20">
        <location>
            <begin position="89"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="21">
        <location>
            <begin position="210"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="34"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00016766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00049220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU361237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="OAG00561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="307" mass="34724" checksum="663CD280C9919157" modified="2016-09-07" version="1">MASTRALCRLATSRTAAVRPAVFARSFASVSDTKARDPISKAGEALAPDASRAPTPESKTSTIKEAAPTKDAKMKTFHIYRWNPDEPTSKPKMQSYELDLNKTGPMMLDALIRIKNEIDPTLTFRRSCREGICGSCAMNIDGVNTLACLCRIPTEEKKESRIYPLPHMYIVKDLVPDMTLFYKQYRSVKPYLQRTTPSPDGREYRQTKEDRKKLDGLYECILCACCSTSCPSYWWNQEEYLGPAVLLQSYRWIADSRDEKKAERQDALNNSMSLYRCHTILNCSRTCPKGLNPALAIAEIKKSMAFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C057</accession>
    <name>A0A177C057_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CC84DRAFT_1155965</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441560">
        <property type="protein sequence ID" value="OAF99989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030355.1">
        <property type="nucleotide sequence ID" value="XM_018176958.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C057"/>
    <dbReference type="STRING" id="1460663.A0A177C057"/>
    <dbReference type="GeneID" id="28760444"/>
    <dbReference type="InParanoid" id="A0A177C057"/>
    <dbReference type="OrthoDB" id="4161332at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF5">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="467"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="6"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="41"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="594"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="595"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="616"/>
            <end position="630"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAF99989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="676" mass="76382" checksum="D073E10064CF678A" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2023-06-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C0N6</accession>
    <name>A0A177C0N6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_187615</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441557">
        <property type="protein sequence ID" value="OAG01354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031719.1">
        <property type="nucleotide sequence ID" value="XM_018185520.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C0N6"/>
    <dbReference type="GeneID" id="28769006"/>
    <dbReference type="InParanoid" id="A0A177C0N6"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG01354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="166" mass="18594" checksum="8B0948EDF805210A" modified="2016-09-07" version="1">MPPLSPPIAKRCHETGVLPRKGTVILPTRFSGASFEFSRSTYVVDNSNRGLDVRVQIHLACGRCLFYLRICKRYTRCLLRTVDCPAIKNCNITGTLSEASGGKNRVFGAHGRGFWCCTPTFKILVFRRQWYVLGIEEVQPDACTLAPLFQTGYTEILRKFVESGGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C0W6</accession>
    <name>A0A177C0W6_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">arginine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CC84DRAFT_1230324</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>tRNA(Arg) + L-arginine + ATP = L-arginyl-tRNA(Arg) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:20301"/>
            <dbReference type="Rhea" id="RHEA-COMP:9658"/>
            <dbReference type="Rhea" id="RHEA-COMP:9673"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78513"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.19"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.19" evidence="2"/>
    <dbReference type="EMBL" id="KV441559">
        <property type="protein sequence ID" value="OAG00357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030722.1">
        <property type="nucleotide sequence ID" value="XM_018183692.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C0W6"/>
    <dbReference type="STRING" id="1460663.A0A177C0W6"/>
    <dbReference type="GeneID" id="28767178"/>
    <dbReference type="InParanoid" id="A0A177C0W6"/>
    <dbReference type="OrthoDB" id="68056at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004814">
        <property type="term" value="F:arginine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006420">
        <property type="term" value="P:arginyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.70">
        <property type="entry name" value="Arginyl tRNA synthetase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001278">
        <property type="entry name" value="Arg-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036695">
        <property type="entry name" value="Arg-tRNA-synth_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035684">
        <property type="entry name" value="ArgRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008909">
        <property type="entry name" value="DALR_anticod-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11956:SF11">
        <property type="entry name" value="ARGININE--TRNA LIGASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11956">
        <property type="entry name" value="ARGINYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05746">
        <property type="entry name" value="DALR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00750">
        <property type="entry name" value="tRNA-synt_1d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01038">
        <property type="entry name" value="TRNASYNTHARG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00836">
        <property type="entry name" value="DALR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55190">
        <property type="entry name" value="Arginyl-tRNA synthetase (ArgRS), N-terminal 'additional' domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9 12" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DALR anticodon binding" evidence="11">
        <location>
            <begin position="524"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="251"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="253"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="264"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OAG00357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="666" mass="74021" checksum="3D234D15C21D53CF" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C0Z9</accession>
    <name>A0A177C0Z9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1222017</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441559">
        <property type="protein sequence ID" value="OAG00512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030877.1">
        <property type="nucleotide sequence ID" value="XM_018183320.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C0Z9"/>
    <dbReference type="GeneID" id="28766806"/>
    <dbReference type="InParanoid" id="A0A177C0Z9"/>
    <dbReference type="OrthoDB" id="10576443at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="279"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG00512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="314" mass="34104" checksum="4D32A35A8251DA66" modified="2016-09-07" version="1">MDSPNSRATTPDLSVTKGTSDMHTLPSTPKTPTLATALELTTTAQDLASGSGTPNQDIALSDSTAQAVSNAVLLPRSPVSTAQEPVASSTTTVPCAQMFAFLTRFEQLAYDKIPNANSISETMHDLDQLAESVKTYQSACSRARTYPDPKSFNVQDLLTEASFIQSTAARLAGTTETYIPTLRGWVRDIKTLMRDAGKTLRFAEGVGTSKHTEMYKLLDALGLLQDSARHVLSQSQNHSVLRQWRADSFAILVREAERLPSESSLVARRWFSNRGPKMLEAVPDTEDRPVTGPVEGLQRMPNNMGETDGVEGCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C1B0</accession>
    <name>A0A177C1B0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1179392</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441557">
        <property type="protein sequence ID" value="OAG01285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031650.1">
        <property type="nucleotide sequence ID" value="XM_018180413.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C1B0"/>
    <dbReference type="GeneID" id="28763899"/>
    <dbReference type="InParanoid" id="A0A177C1B0"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG01285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="244" mass="26808" checksum="79633D1C2FB1A1B7" modified="2016-09-07" version="1">MPCNYHSTTQGMRRSHSSSLSTWCSDRYKCTCLAVCSNDSHSARRVNTLDSTLCSYCHIIKHTNSIKHLLSLTALIVALTNTASTFVTQSKRDFINIGSVDFTISPLTGPTVSAGYYSSYMSRYSEAAWAAVMDKDTEWGSSIIDARLDMLDFLATQTAVSIRTVIMGELVKTAYTEMPEWYTKLRENIHQILEEDPEIFKQALMDKPTAAPSGGGAYANAVKIGNRPVAADLAGIALLSNRNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2023-09-13" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C1L2</accession>
    <name>A0A177C1L2_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF4939 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1101367</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441558">
        <property type="protein sequence ID" value="OAG01101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031466.1">
        <property type="nucleotide sequence ID" value="XM_018174911.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C1L2"/>
    <dbReference type="GeneID" id="28758397"/>
    <dbReference type="InParanoid" id="A0A177C1L2"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG01101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="53" mass="6384" checksum="CC44CB0471161C47" modified="2016-09-07" version="1" fragment="single">LDLYFYEENKDKDDKDKVLFAASYMRGDVGEWIRPYITKYLDIDDDNVNPNYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C1L4</accession>
    <name>A0A177C1L4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_1102434</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441559">
        <property type="protein sequence ID" value="OAG00688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031053.1">
        <property type="nucleotide sequence ID" value="XM_018174965.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C1L4"/>
    <dbReference type="STRING" id="1460663.A0A177C1L4"/>
    <dbReference type="GeneID" id="28758451"/>
    <dbReference type="InParanoid" id="A0A177C1L4"/>
    <dbReference type="OrthoDB" id="5391602at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF134">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="39"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="91"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="125"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="175"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="209"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="251"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="24"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAG00688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="309" mass="33556" checksum="3071392C3E864A3E" modified="2016-09-07" version="1">MDATSVKITTSILSVVATLAVGGRFWARRIKKQHYGLDDWTVLASLVVMWALAAVILAGAVVGLYHSHDVDTTSAGQLETTGREQLISKYNFVKCILLIAGIGLVKLSVVFLYRRIFNVVRTFKIYSLTLIVLLAGWTVAFLFANIFQCSVHISALWGSAEGILRYCKTSGPASYGFVVSDIITDVLVLVSPVPIVWHMKVSTGRKLGITGIFGLGLLSTAAACGRLSTFLKALHSELLPISRLPRADAELAIWAVIELSVAVVAACLPVMRPLFQSHGLGGFVTSVRSGSIHRSRQKEQPSWMEINDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C1S6</accession>
    <name>A0A177C1S6_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Lysine-specific metallo-endopeptidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1220909</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441557">
        <property type="protein sequence ID" value="OAG01396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031761.1">
        <property type="nucleotide sequence ID" value="XM_018183209.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C1S6"/>
    <dbReference type="GeneID" id="28766695"/>
    <dbReference type="InParanoid" id="A0A177C1S6"/>
    <dbReference type="OrthoDB" id="3482317at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG01396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="138" mass="15802" checksum="577861DF135E87E8" modified="2016-09-07" version="1">MVFCDYFWSQNFPHLLDRVLDKPTYALDNFITQEHVILHELTHADIAGSQGHIDDIKVKLPSETNDVNIPRGITDESSTAYAWFAMSKYFRDAWVIHLNEPKGFINGSVTPLDSAHEQPNNGDWYAGDEFTDVEWTAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C3Z4</accession>
    <name>A0A177C3Z4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CENP-V/GFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CC84DRAFT_993715</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfa family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441556">
        <property type="protein sequence ID" value="OAG02126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032491.1">
        <property type="nucleotide sequence ID" value="XM_018188065.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C3Z4"/>
    <dbReference type="STRING" id="1460663.A0A177C3Z4"/>
    <dbReference type="GeneID" id="28771551"/>
    <dbReference type="InParanoid" id="A0A177C3Z4"/>
    <dbReference type="OrthoDB" id="1601230at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016846">
        <property type="term" value="F:carbon-sulfur lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1590.10">
        <property type="entry name" value="glutathione-dependent formaldehyde- activating enzyme (gfa)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006913">
        <property type="entry name" value="CENP-V/GFA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337:SF30">
        <property type="entry name" value="DUF636 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G03180)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337">
        <property type="entry name" value="GFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04828">
        <property type="entry name" value="GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51891">
        <property type="entry name" value="CENP_V_GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CENP-V/GFA" evidence="5">
        <location>
            <begin position="4"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAG02126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="141" mass="15658" checksum="52A02EDBE9B8A626" modified="2016-09-07" version="1">MSSYKGHCHCGNTEWEAKLEADQQGHILCHCDTCKSLSGSTFTLNQIIPKAALNITKGESDLGKYTYYGESGKGVHCYFCKNCTSHVYHHQEVMGPDTIVLRTGLLTEGIKNFEPKAEIFGKAKLPWEKEVATTFETLPPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C409</accession>
    <name>A0A177C409_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_1099681</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441557">
        <property type="protein sequence ID" value="OAG01410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031775.1">
        <property type="nucleotide sequence ID" value="XM_018174837.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C409"/>
    <dbReference type="GeneID" id="28758323"/>
    <dbReference type="InParanoid" id="A0A177C409"/>
    <dbReference type="OrthoDB" id="3362851at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF17">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="20"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAG01410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="464" mass="51950" checksum="52B93F316223836B" modified="2016-09-07" version="1">MSSPFSPTSNLRRKRTVEGSCWPCKQRRIKCDLTKPACHRCIASGTEDCSYDKLLLRWKKRPSKSMPETTQQSLLVHRSLNDMSLATNERRAVDYFKGRLWPLFSTVHEPIPPPVALALRSQPVLQALCVFAEEHRALQEKGQAQHTLENRRLHCLTVIRGELGLEQTETASLSALLVAVLLLYFLEGYVNCADDDASTPCHASGASAILDALGGFDAAYMSSDKMTRMLLSEFASTDLTEAMMQDRRTRFPSVIWARMEPGSVWWESPLGNRSLATVLGTMADMTSYRQDVKEGTEPCNEMIQAFERALQPSFSMLEHSAEEQKPLGLKCDLFDAVTASSLSLNRSFQHAGLIYLYSAILHIPNHHFLVQQHVHACLECIQGMDPKTKVQNCALFPLYVAGAHAISGPHKATVLEKLDVIYKNLRFESVTCVRMTLEQIWTTSSHTSTWNDLFKGVSPCALVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C486</accession>
    <name>A0A177C486_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Trs120-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CC84DRAFT_1153721</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441557">
        <property type="protein sequence ID" value="OAG01692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032057.1">
        <property type="nucleotide sequence ID" value="XM_018176853.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A177C486">
        <property type="interactions" value="31"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177C486"/>
    <dbReference type="GeneID" id="28760339"/>
    <dbReference type="InParanoid" id="A0A177C486"/>
    <dbReference type="OrthoDB" id="27962at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058565">
        <property type="entry name" value="Ig_TRAPPC9_Trs120_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058567">
        <property type="entry name" value="Ig_TRAPPC9_Trs120_3rd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058568">
        <property type="entry name" value="Ig_TRAPPC9_Trs120_4th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058564">
        <property type="entry name" value="TPR_TRAPPC9_Trs120"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013935">
        <property type="entry name" value="Trs120_TRAPPC9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058563">
        <property type="entry name" value="Trs120_TRAPPC9_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21512">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21512:SF5">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26254">
        <property type="entry name" value="Ig_TRAPPC9-Trs120_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26280">
        <property type="entry name" value="Ig_TRAPPC9-Trs120_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26282">
        <property type="entry name" value="Ig_TRAPPC9-Trs120_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26283">
        <property type="entry name" value="Ig_TRAPPC9-Trs120_4th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26251">
        <property type="entry name" value="TPR_TRAPPC9-Trs120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08626">
        <property type="entry name" value="TRAPPC9-Trs120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Trs120/TRAPPC9 N-terminal" evidence="4">
        <location>
            <begin position="5"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="domain" description="Trs120/TRAPPC9 TPR region" evidence="5">
        <location>
            <begin position="465"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="domain" description="Trs120/TRAPPC9 first Ig-like" evidence="6">
        <location>
            <begin position="801"/>
            <end position="989"/>
        </location>
    </feature>
    <feature type="domain" description="Trs120/TRAPPC9 third Ig-like" evidence="7">
        <location>
            <begin position="1142"/>
            <end position="1332"/>
        </location>
    </feature>
    <feature type="domain" description="Trs120/TRAPPC9 fourth Ig-like" evidence="8">
        <location>
            <begin position="1337"/>
            <end position="1497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="217"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="434"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="120"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="217"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="274"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="290"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="315"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="328"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="434"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF26251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF26254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF26282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF26283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAG01692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="1499" mass="165118" checksum="004A8FA381A348D0" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C4I4</accession>
    <name>A0A177C4I4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">p-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1150638</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG02654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033019.1">
        <property type="nucleotide sequence ID" value="XM_018176714.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C4I4"/>
    <dbReference type="STRING" id="1460663.A0A177C4I4"/>
    <dbReference type="GeneID" id="28760200"/>
    <dbReference type="InParanoid" id="A0A177C4I4"/>
    <dbReference type="OrthoDB" id="10042665at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19481">
        <property type="entry name" value="RecA-like_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056599">
        <property type="entry name" value="AAA_lid_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054289">
        <property type="entry name" value="DUF7025"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46411:SF4">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46411">
        <property type="entry name" value="FAMILY ATPASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23232">
        <property type="entry name" value="AAA_lid_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22942">
        <property type="entry name" value="DUF7025"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="2">
        <location>
            <begin position="511"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="745"/>
            <end position="777"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG02654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="777" mass="89593" checksum="8E576AAD1C47F4C6" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C4X8</accession>
    <name>A0A177C4X8_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1167530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441556">
        <property type="protein sequence ID" value="OAG02486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032851.1">
        <property type="nucleotide sequence ID" value="XM_018179194.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C4X8"/>
    <dbReference type="GeneID" id="28762680"/>
    <dbReference type="InParanoid" id="A0A177C4X8"/>
    <dbReference type="OrthoDB" id="3794209at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG02486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="224" mass="24978" checksum="56E49500125F2127" modified="2016-09-07" version="1">MPSNIPATPAPPKVEGSNRSASPDRKSSPPIVQTHLHRASDILKDNALAHTLTTFINEGYATSSLYPSTRWDHQPVRFHTPTDIHDMLGTDGMIAAIYHISREGGQTEPVAVASISRWHGDMDGVGAQDEDGWEIKAVTTKSGWGKMGLVGRCIETITQDLIAQEQSHGEEKVKLWLHAVEEVNGDYWRRRGWNDVRGFNRPEGYWGSKFGFRLSVLLKEVDVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C5M6</accession>
    <name>A0A177C5M6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1167498</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441556">
        <property type="protein sequence ID" value="OAG02451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032816.1">
        <property type="nucleotide sequence ID" value="XM_018179187.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C5M6"/>
    <dbReference type="STRING" id="1460663.A0A177C5M6"/>
    <dbReference type="GeneID" id="28762673"/>
    <dbReference type="InParanoid" id="A0A177C5M6"/>
    <dbReference type="OrthoDB" id="10549983at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008057766" evidence="2">
        <location>
            <begin position="17"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="261"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG02451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="303" mass="34486" checksum="5B9D7534B32BE251" modified="2016-09-07" version="1">MRSTIILATLAISAFAAPVQNAESRSAAPLESNFEARLAEPWTRKGSVRRSASPEPYVRGGHKREAYVRGGHKRDAEDEEEADVDGLVTRYVRGGHKREVEEEDEELEARYVRGGHKREAEPYVRGGHKREAEPYVRGGHKREAEPYTRGGHKRDVEDDEEELEARYVRGGHKREAEPYVRGGHKREAEPYTRGGHKRDVEDDEEELEARYVRGGHKREAEPYVRGGHKREAEEEDEELEARYVRGGHKREAEPYVRGGHKREAEARPEPYVRGGHKRSTWASGLIEALKARGFSSATLQNAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C5V4</accession>
    <name>A0A177C5V4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Cation efflux system protein czcD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CC84DRAFT_1151252</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG03003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033368.1">
        <property type="nucleotide sequence ID" value="XM_018176738.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C5V4"/>
    <dbReference type="STRING" id="1460663.A0A177C5V4"/>
    <dbReference type="GeneID" id="28760224"/>
    <dbReference type="InParanoid" id="A0A177C5V4"/>
    <dbReference type="OrthoDB" id="9944568at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006882">
        <property type="term" value="P:intracellular zinc ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027470">
        <property type="entry name" value="Cation_efflux_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036837">
        <property type="entry name" value="Cation_efflux_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45820:SF5">
        <property type="entry name" value="DIFFUSION FACILITATOR FAMILY METAL ION TRANSPORTER, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45820">
        <property type="entry name" value="FI23527P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16916">
        <property type="entry name" value="ZT_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160240">
        <property type="entry name" value="Cation efflux protein cytoplasmic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="180"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="210"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="9">
        <location>
            <begin position="14"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein cytoplasmic" evidence="10">
        <location>
            <begin position="244"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF16916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OAG03003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="355" mass="38691" checksum="109E86650ED3B267" modified="2016-09-07" version="1">MAHFQISRKTRLRAVIAISVTFFLAEISTGFYTKSLALVADAFHYLTDLIGFIVALVAVHMQERKDAPVALSFGWARASLLGAFFNGVFLLALGLSILLQSVERFIDIKEVEKPEIVLIVGSVGLALNLISGIFLHEHDHGDGHEHAVHIDELAGLNHSEHNHHNLLASKKHRDLGMLGAMIHVLGDAFNNIGVIISALVIWLTHSPKRFYIDPAISLYIALMILGTAIPLTRRSGTILLESAPDGVVLDHVKKDLESIPGVLGVHELHVWRLNQTKSLASAHIVVRDTEVRDFIGRAKIISECLHAYGIHSATLQPELADGSEVEPGGEAQQTEGVGKCTITCGTFCEPLKCCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C753</accession>
    <name>A0A177C753_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12 15">Protein disulfide-isomerase</fullName>
            <ecNumber evidence="5 15">5.3.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CC84DRAFT_1124344</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Participates in the folding of proteins containing disulfide bonds, may be involved in glycosylation, prolyl hydroxylation and triglyceride transfer.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 15">
            <text>Catalyzes the rearrangement of -S-S- bonds in proteins.</text>
            <dbReference type="EC" id="5.3.4.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the protein disulfide isomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.3.4.1" evidence="5 15"/>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG02577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032942.1">
        <property type="nucleotide sequence ID" value="XM_018175687.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C753"/>
    <dbReference type="FunCoup" id="A0A177C753">
        <property type="interactions" value="773"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177C753"/>
    <dbReference type="GeneID" id="28759173"/>
    <dbReference type="InParanoid" id="A0A177C753"/>
    <dbReference type="OrthoDB" id="427280at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003756">
        <property type="term" value="F:protein disulfide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034976">
        <property type="term" value="P:response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02961">
        <property type="entry name" value="PDI_a_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02995">
        <property type="entry name" value="PDI_a_PDI_a'_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02982">
        <property type="entry name" value="PDI_b'_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02981">
        <property type="entry name" value="PDI_b_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000139">
        <property type="entry name" value="Protein disulfide-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000154">
        <property type="entry name" value="Protein disulfide-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000185">
        <property type="entry name" value="Protein disulfide-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000017">
        <property type="entry name" value="Protein disulfide-isomerase A4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005788">
        <property type="entry name" value="PDI_thioredoxin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005792">
        <property type="entry name" value="Prot_disulphide_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01130">
        <property type="entry name" value="ER_PDI_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01126">
        <property type="entry name" value="pdi_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18929">
        <property type="entry name" value="PROTEIN DISULFIDE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18929:SF132">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13848">
        <property type="entry name" value="Thioredoxin_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00421">
        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10 15 18" id="KW-0413">Isomerase</keyword>
    <keyword evidence="11 13" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 15" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007948944" description="Protein disulfide-isomerase" evidence="15">
        <location>
            <begin position="18"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="17">
        <location>
            <begin position="5"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="17">
        <location>
            <begin position="335"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="479"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="485"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="504"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="519"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="13">
        <location>
            <begin position="47"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="13">
        <location>
            <begin position="382"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00039846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR605792-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU361130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="OAG02577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="545" mass="59141" checksum="0A3452581A929504" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C7A9</accession>
    <name>A0A177C7A9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_912380</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG02749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033114.1">
        <property type="nucleotide sequence ID" value="XM_018187881.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C7A9"/>
    <dbReference type="STRING" id="1460663.A0A177C7A9"/>
    <dbReference type="GeneID" id="28771367"/>
    <dbReference type="InParanoid" id="A0A177C7A9"/>
    <dbReference type="OrthoDB" id="3554680at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG02749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="174" mass="19531" checksum="111265E69BC41C7C" modified="2016-09-07" version="1">MNDENALITMRKIQIILFWLNYTQKAHFIAQTFFNIIGLQEHFTDAVLYPSIEVTENALRCTLPTTFVQETADPIKLWAAASHYDPVPFSNPFGKSVLRCGIEPCGASIYDEDNQDVSPRDSEKIRKARAKHLINIFGIRGRFENSGTGLPKPVMAGKPPASIHFNLRIGVART</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2023-06-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C7E2</accession>
    <name>A0A177C7E2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_919493</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG02779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033144.1">
        <property type="nucleotide sequence ID" value="XM_018187889.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C7E2"/>
    <dbReference type="GeneID" id="28771375"/>
    <dbReference type="InParanoid" id="A0A177C7E2"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG02779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="149" mass="16252" checksum="87D650F75FC49A0E" modified="2016-09-07" version="1">MLGASGAVTCQCICICSSTDNTKDRLRRASLTSLHTRCNPKTTSQCLVNCIHRLELCLSEPPSGTDRTCQESTNGLRVGEERNLSFVSLAKTDQKQLRYGILTRAAFIHDPLKSVLLTVRGFPVGIRVGFPVGIRVGFPMCRVGGRSIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C7K0</accession>
    <name>A0A177C7K0_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_1261448</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG02748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033113.1">
        <property type="nucleotide sequence ID" value="XM_018185070.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C7K0"/>
    <dbReference type="STRING" id="1460663.A0A177C7K0"/>
    <dbReference type="GeneID" id="28768556"/>
    <dbReference type="InParanoid" id="A0A177C7K0"/>
    <dbReference type="OrthoDB" id="3162524at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000039">
        <property type="entry name" value="Neutral amino acid transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF697">
        <property type="entry name" value="AMINO ACID TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="48"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="114"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="144"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="170"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="255"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="297"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="343"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="370"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="404"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="7">
        <location>
            <begin position="38"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAG02748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="454" mass="49013" checksum="92EDEC2ABEC0B573" modified="2016-09-07" version="1">MADKQYRCQANLCLVLRCNIVSGLPQPLLTLFSIFRPRATIIFLKIQFAMSILAVPGALATLGAVGGALSIVGWQILNTYTAVILGDFRNRHPECHTLADMCGLLFGWIGRELVGLQIMIAQVLITAAGIVSCSTALNALSNHGACTVWFSFVSAVLITGFSSVRTFSRLGWLTWVGFFTFFIAVFIFVVAVTQQGRPAIAPKTGHFELGWTAIAYPSFAAGITASANIFISGSGSMMYMPVVSEMKKPTDYRKACLVAGFFVGVLYLTFSLVIYRWCGVWIATPAFGSAGTLFKKISYGIALPGLVIGVGIYQHVAAKLIFVRILRNTHHLQENTMVHWTTWLGSNLILGILGFIIASAVPILNYLLGLAGSLCFAPFSLVFPALLWMYDFKGYRSGGISQKLIYGLHIIIVLIGLFMVVGGTYGVALSIKEAYATGIIGKAFDCADNSGSVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C7K5</accession>
    <name>A0A177C7K5_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cora-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CC84DRAFT_1166864</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG03111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033476.1">
        <property type="nucleotide sequence ID" value="XM_018179067.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C7K5"/>
    <dbReference type="STRING" id="1460663.A0A177C7K5"/>
    <dbReference type="GeneID" id="28762553"/>
    <dbReference type="InParanoid" id="A0A177C7K5"/>
    <dbReference type="OrthoDB" id="165352at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050897">
        <property type="term" value="F:cobalt ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015087">
        <property type="term" value="F:cobalt ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.20">
        <property type="entry name" value="CorA soluble domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045861">
        <property type="entry name" value="CorA_cytoplasmic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045863">
        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46494">
        <property type="entry name" value="CORA FAMILY METAL ION TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46494:SF1">
        <property type="entry name" value="CORA FAMILY METAL ION TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143865">
        <property type="entry name" value="CorA soluble domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="533"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="567"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="234"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="268"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="58"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="76"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="235"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="268"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="283"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAG03111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="661" mass="74756" checksum="06B9B029C16AB1B3" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C915</accession>
    <name>A0A177C915_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1166181</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG04055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034420.1">
        <property type="nucleotide sequence ID" value="XM_018178890.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C915"/>
    <dbReference type="GeneID" id="28762376"/>
    <dbReference type="InParanoid" id="A0A177C915"/>
    <dbReference type="OrthoDB" id="3751104at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG04055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="189" mass="20836" checksum="46ED1B1F0C7A8FC8" modified="2016-09-07" version="1">MSPRLKALQGAQLGIVALTLLATFLAAVVPHKHKSFTFGLLYPLLLTSASTTFLIAREQRRAREGALTKAKYAKYALLKLAAAFGLGFVGFVLDIATTDGKCDVQRPGETGLWIRCVKVETWQGAILWLNVFNWLFLWAGVFYSCCMSRRTEGAIALGGEEARIGLDNETENDEAIARDLQAQDPNWRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C955</accession>
    <name>A0A177C955_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PLAC8-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1125647</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG03308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033673.1">
        <property type="nucleotide sequence ID" value="XM_018175725.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C955"/>
    <dbReference type="STRING" id="1460663.A0A177C955"/>
    <dbReference type="GeneID" id="28759211"/>
    <dbReference type="InParanoid" id="A0A177C955"/>
    <dbReference type="OrthoDB" id="1045822at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006461">
        <property type="entry name" value="PLAC_motif_containing"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01571">
        <property type="entry name" value="A_thal_Cys_rich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15907">
        <property type="entry name" value="DUF614 FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04749">
        <property type="entry name" value="PLAC8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="155"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG03308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="444" mass="48550" checksum="BB3AD648936F76AC" modified="2016-09-07" version="1">MDPRQNPHQHQSSGRQHQRFSWQIPPSTPPEEPIQAHQSAQQPQHTTPLNTNIDARHNRVFSYAQTPAEHLAFQYIPSPSEPVPPLPHHSPTHQPQSPTTPIDPRPQSVFQPVGAANYSASHPQQPVPQTSYLSTSPAYEEKPPVSPLSPHNYHPSALPLSPVSPAFPVTPTDPPRIYTSQPQPQQQHHTQHARNLSNLSPLNTNIHSNINNMPPMPPMPAQADPTHAAPLTPSSIKKDPADFHPQTPRSYAHEAYSPHNGNVSATQKTPGGIFSPDSAHGPNGLDFALHQPGQVAHPNMDLSPSGAKHAWTSSLCTPSSDCLTGLFCPCILYGRTAHRLSQKSAKQDPTDLLGYSATNGHCLLMAVSCGLWWVYPMVQRARVRHVYKLEGDVGGDCVRSVCCCCCVAVQNEREVRGREEAKRQHAGPAAGYKSVGQMAYVPQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C964</accession>
    <name>A0A177C964_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF7728 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CC84DRAFT_1207965</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG03260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033625.1">
        <property type="nucleotide sequence ID" value="XM_018182130.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C964"/>
    <dbReference type="GeneID" id="28765616"/>
    <dbReference type="InParanoid" id="A0A177C964"/>
    <dbReference type="OrthoDB" id="5409353at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056145">
        <property type="entry name" value="DUF7728"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40622">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40622:SF1">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24854">
        <property type="entry name" value="DUF7728"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008057962" description="DUF7728 domain-containing protein" evidence="3">
        <location>
            <begin position="19"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="282"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7728" evidence="4">
        <location>
            <begin position="47"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="325"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="336"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAG03260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="372" mass="41230" checksum="47611701EAC0ADD5" modified="2016-09-07" version="1">MISRTLNLALAAAGAASAILIPPSVSSAELDLGDDMAMEIVATSYPRSVSLDCATCEFASKEADDLVWTQRNGNSFLLDFEVGPREDSLTIDGTQLYPPTFGYFTQPFRVAQINPDGENLTLRVTGYTFHYNSAETVSEAGIELIPMTFQINSIEGKAVAPPALTINLLKDPNGKLMIASFQTAKPNEKSPIDEEKECKEWPLYCKWKAIMADKVNGIKSHMGRPGCHKNKGNPMAGELYEGKPPHRFRPGHPHHRPHHMAGSHGHRHHRGHRMHMMLRRVFLTVFIPILIGIFAGTLTYLVGMALGCLIAVVVAKARGQPMYESVAQEEEDSENVEDRGEKEVYTESELPQYDAPPVYEEAVEKEVVEDKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C994</accession>
    <name>A0A177C994_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1260572</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG03409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033774.1">
        <property type="nucleotide sequence ID" value="XM_018184996.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C994"/>
    <dbReference type="GeneID" id="28768482"/>
    <dbReference type="InParanoid" id="A0A177C994"/>
    <dbReference type="OrthoDB" id="3870692at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="114"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="244"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="291"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG03409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="323" mass="35276" checksum="236CD3B3103BAD14" modified="2016-09-07" version="1">MAKVRRIRIPYDSHPLYSLRRSILIAGTVGVLLNTAILLALSSSYGGMYRLPNFVLSTALLCGSIAFVSYDLVTYGTRTAVILASQAKDDDTLLPQVAHAQPTWPSKVLLVGDFIFAVALQWLFWGLFFVVASSGYYDRYGGSETLEAYANLTNFAASVLHGVAFWKELLARKKSQWQRDLDTRPCGHCGHVTSIQDEASHSEAVITALNEQAGPSSEPGPSTHPTHTNFGRIRKLVLPKWARPASVRRHDSTDDRDVEKEAAGDGAGEPLLVTPDESTEFAGQPSGTYGSMSQSVESLSSVPETIVKKKDKGKKRMVDVDEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C9B9</accession>
    <name>A0A177C9B9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">AAA-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CC84DRAFT_1166119</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG03976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034341.1">
        <property type="nucleotide sequence ID" value="XM_018178879.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C9B9"/>
    <dbReference type="FunCoup" id="A0A177C9B9">
        <property type="interactions" value="601"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177C9B9"/>
    <dbReference type="GeneID" id="28762365"/>
    <dbReference type="InParanoid" id="A0A177C9B9"/>
    <dbReference type="OrthoDB" id="10254455at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140567">
        <property type="term" value="F:membrane protein dislocase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140570">
        <property type="term" value="P:extraction of mislocalized protein from mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034214">
        <property type="term" value="P:protein hexamerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045047">
        <property type="term" value="P:protein targeting to ER"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006626">
        <property type="term" value="P:protein targeting to mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000538">
        <property type="entry name" value="ATPase family AAA domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051701">
        <property type="entry name" value="Mito_OM_Translocase_MSP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45644">
        <property type="entry name" value="AAA ATPASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G12920)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45644:SF3">
        <property type="entry name" value="FI08533P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="9">
        <location>
            <begin position="151"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="397"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="402"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="424"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAG03976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="442" mass="48798" checksum="2D132C4F90DF5B38" modified="2016-09-07" version="1">MSSNKKSSLTGYLPDIIMAMAAPAIAYFIIRNLLARLDPDAQQKEEAKRKASAANRKLGAILSNKARDAYDSDSDDDYERRRRGDRPRIEDLNLTAYEQTIAMEVVAPEEIPVSFDDIGGLDPIIEELKESVIYPLTLPHLYSHSSSLLSAPSGVLLYGPPGCGKTMLAKALAHESGACFINLHISTITEKWYGDSNKLVSAVFSLARKLQPSIVFIDEIDAVLGQRRSGEHEASGMVKAEFMTQWDGLTSATRSGSGDPQRICILGATNRIQDIDEAILRRMPKKFPVALPNAGQRNKIFSLILRGTQIDKQNFDLDYIVRLSAGMSGSDIKEACRDAAMGPVREYIRKMKKEGRLRQGVNPQDVRGLRTEDFFGRGRGLREVDSPELDDVADEVVNVKEGGGRRIHTTEESDTTSSSSTESGEDKFRDSAYHDAEGARVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C9Q5</accession>
    <name>A0A177C9Q5_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="15">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">CC84DRAFT_1165737</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="15"/>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG03508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033873.1">
        <property type="nucleotide sequence ID" value="XM_018178786.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C9Q5"/>
    <dbReference type="FunCoup" id="A0A177C9Q5">
        <property type="interactions" value="965"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177C9Q5"/>
    <dbReference type="GeneID" id="28762272"/>
    <dbReference type="InParanoid" id="A0A177C9Q5"/>
    <dbReference type="OrthoDB" id="361536at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02658">
        <property type="entry name" value="Peptidase_C19B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14385">
        <property type="entry name" value="UBA1_spUBP14_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14386">
        <property type="entry name" value="UBA2_UBP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000086">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000103">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000396">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000235">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000144">
        <property type="entry name" value="Ubiquitinyl hydrolase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050185">
        <property type="entry name" value="Ub_carboxyl-term_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016652">
        <property type="entry name" value="Ubiquitinyl_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001607">
        <property type="entry name" value="Znf_UBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646:SF10">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00627">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02148">
        <property type="entry name" value="zf-UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016308">
        <property type="entry name" value="UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00165">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00290">
        <property type="entry name" value="ZnF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50271">
        <property type="entry name" value="ZF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 15" id="KW-0645">Protease</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="9 15" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="7 15" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="10 13" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UBP-type" evidence="19">
        <location>
            <begin position="2"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="18">
        <location>
            <begin position="153"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="17">
        <location>
            <begin position="446"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="17">
        <location>
            <begin position="512"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="556"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="11">
        <location>
            <position position="162"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="603"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="26"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="48"/>
            <end position="51"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR016308-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR016308-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR016308-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU366025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="OAG03508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="649" mass="71480" checksum="05DE878F73E85D10" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CAJ0</accession>
    <name>A0A177CAJ0_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Vacuolar calcium ion transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CC84DRAFT_1096464</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Has a role in promoting intracellular calcium ion sequestration via the exchange of calcium ions for hydrogen ions across the vacuolar membrane. Involved also in manganese ion homeostasis via its uptake into the vacuole.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Vacuole membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG03788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034153.1">
        <property type="nucleotide sequence ID" value="XM_018174669.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CAJ0"/>
    <dbReference type="STRING" id="1460663.A0A177CAJ0"/>
    <dbReference type="GeneID" id="28758155"/>
    <dbReference type="InParanoid" id="A0A177CAJ0"/>
    <dbReference type="OrthoDB" id="1699231at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015369">
        <property type="term" value="F:calcium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="entry name" value="NCX, central ion-binding region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004713">
        <property type="entry name" value="CaH_exchang"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004798">
        <property type="entry name" value="CAX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00378">
        <property type="entry name" value="cax"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503">
        <property type="entry name" value="VACUOLAR CALCIUM ION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503:SF14">
        <property type="entry name" value="VACUOLAR CALCIUM ION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0050">Antiport</keyword>
    <keyword evidence="6 10" id="KW-0106">Calcium</keyword>
    <keyword evidence="4 10" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="8 10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <keyword evidence="10" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="47"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="104"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="180"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="218"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="269"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="339"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="374"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="398"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="12">
        <location>
            <begin position="73"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="12">
        <location>
            <begin position="274"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OAG03788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="445" mass="48679" checksum="082BA57882D2D9BD" modified="2016-09-07" version="1">MHLPRFNHNGHKVTKGIEPEGESGRKGFHPLKFFKISYKSNSVISRWVNILWPMVPVAIALHFALPNTKGAHLAIFITNFIAMVPAANTVGFCGSELARKLPKVLGVIVETTLGSVVEIVLFMVLLVTGREQNVPVIRAAILGSILANMLLCLGFCFVAGGLKGGEQSFHEAISEAGSGLMLVAAMGLVLPTVYYNALNGRTDLELAVNEISDEMLKISRATAIILLIAYFVYLLFQLKSHDNLFHEIYERDELIDKDRNKELAKPKLTLTECIIGLLISLACVSMIAVFLVIEIPHMVEERHISDSFMGLILVPVVEKAAEHLLAIDEAWDGQMNLALAHVLGASIQTALLNTPLVIIVGWGLNIGMNMQFEVFDAVSLVLAVLVVGSFLRDRKSNYMEGSLLIFVYVIIAIAAFYYPNPPHGGGESTGAESGGETTAHERRFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CBA0</accession>
    <name>A0A177CBA0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">FAD-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CC84DRAFT_1150051</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG04129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034494.1">
        <property type="nucleotide sequence ID" value="XM_018176688.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CBA0"/>
    <dbReference type="STRING" id="1460663.A0A177CBA0"/>
    <dbReference type="GeneID" id="28760174"/>
    <dbReference type="InParanoid" id="A0A177CBA0"/>
    <dbReference type="OrthoDB" id="2151789at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF13">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012272210" evidence="5">
        <location>
            <begin position="16"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="6">
        <location>
            <begin position="69"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAG04129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="520" mass="57003" checksum="A9B67E932C4C35F4" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CBP5</accession>
    <name>A0A177CBP5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HET-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1207360</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG04197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034562.1">
        <property type="nucleotide sequence ID" value="XM_018182097.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CBP5"/>
    <dbReference type="STRING" id="1460663.A0A177CBP5"/>
    <dbReference type="GeneID" id="28765583"/>
    <dbReference type="InParanoid" id="A0A177CBP5"/>
    <dbReference type="OrthoDB" id="3477286at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF64">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="2">
        <location>
            <begin position="79"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="304"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="465"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="859"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1063"/>
            <end position="1088"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1124"/>
            <end position="1155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="304"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="314"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="467"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="885"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1134"/>
            <end position="1155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG04197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="1251" mass="144634" checksum="2ED576D9BEEE428E" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CBR2</accession>
    <name>A0A177CBR2_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Glucanase</fullName>
            <ecNumber evidence="11">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CC84DRAFT_1219423</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endohydrolysis of (1-&gt;4)-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans.</text>
            <dbReference type="EC" id="3.2.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the glycosyl hydrolase 7 (cellulase C) family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="11"/>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG04217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034582.1">
        <property type="nucleotide sequence ID" value="XM_018183080.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CBR2"/>
    <dbReference type="SMR" id="A0A177CBR2"/>
    <dbReference type="STRING" id="1460663.A0A177CBR2"/>
    <dbReference type="GeneID" id="28766566"/>
    <dbReference type="InParanoid" id="A0A177CBR2"/>
    <dbReference type="OrthoDB" id="412382at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008810">
        <property type="term" value="F:cellulase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030248">
        <property type="term" value="F:cellulose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07999">
        <property type="entry name" value="GH7_CBH_EG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.100.10">
        <property type="entry name" value="Glycoside hydrolase, family 7, domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000254">
        <property type="entry name" value="CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035971">
        <property type="entry name" value="CBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001722">
        <property type="entry name" value="Glyco_hydro_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037019">
        <property type="entry name" value="Glyco_hydro_7_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33753">
        <property type="entry name" value="1,4-BETA-D-GLUCAN CELLOBIOHYDROLASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33753:SF1">
        <property type="entry name" value="ENDO-BETA-1,4-GLUCANASE CELB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00734">
        <property type="entry name" value="CBM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00840">
        <property type="entry name" value="Glyco_hydro_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00734">
        <property type="entry name" value="GLHYDRLASE7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00236">
        <property type="entry name" value="fCBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57180">
        <property type="entry name" value="Cellulose-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00562">
        <property type="entry name" value="CBM1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51164">
        <property type="entry name" value="CBM1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5 11" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 11" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 11" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 13" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008057981" description="Glucanase" evidence="13">
        <location>
            <begin position="22"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="domain" description="CBM1" evidence="14">
        <location>
            <begin position="445"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="427"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="427"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OAG04217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="481" mass="50276" checksum="5BC99A8C6D6104B0" modified="2016-09-07" version="1">MAPRFASVLAVALAGCQLAIAQNPDDTAEVHPKLTTYKCTKAGGCVAQDTSVVIDWNYHWFHTADWLSCTTASGAINTTLCPDEATCAKNCFVQGDTNYTANGVTTSGDTLTMYQYTKNSDGAYQNASPRLYLLGSDGNYEMLQLNGQELTFTVDLSQLPCGENGALYLGEMDKTGGRSEYNQGGANYGGGYCDAQCPVQNWRNGTVNTSGAGYCCNEMDILEANSKAIAFTPHPCTDSDCDRNGCGFNPYSQGYHNYYGPGGTVDTTKPFTVVTQFNTNDGTASGTLTSITRKYLQNGVVVASANTGGDTLTSEMCNSLDSTAAAFGGLATSGKALARGMVLTFAIWNDATGYMNWLDTGSNGPCSTTEGNPSLIIQNNPTTHVVFSGIRWGDIGSTFSSGSGSGTTTSKAGTTLTTSKASTATASTKATTTTKASTTSSAAGPAQTHYGQCGGKGWTGPTACVSPYKCVVSNDYYSQCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CBX0</accession>
    <name>A0A177CBX0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CC84DRAFT_804748</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG04826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035191.1">
        <property type="nucleotide sequence ID" value="XM_018187490.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CBX0"/>
    <dbReference type="GeneID" id="28770976"/>
    <dbReference type="InParanoid" id="A0A177CBX0"/>
    <dbReference type="OrthoDB" id="3639251at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000386">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000065">
        <property type="entry name" value="Putative MFS pantothenate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF39">
        <property type="entry name" value="TRANSPORTER LIZ1_SEO1, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G00980)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="150"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="185"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="218"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="358"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="384"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="452"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="59"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="480"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="494"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OAG04826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="507" mass="57827" checksum="51192A4ACAD0F391" modified="2016-09-07" version="1">MGHTPFHPRTLDSPNELPQVIEASEEVKQQPRKWYYYLWDTLDKPKEERWFMFKLDAALLTFASLGYFIKYLDQTNINSAFVSGMKEDLGLYKNQLNYMQTCWTVGYVIGELPSNMILTRFRPSRWIPCMEMIWAVLTFCLARANNATTIYVLRFFIGLAESTFYPGMQYIIGSWYRKEELAKRSCIFHTSSALGTMFSGYLMAAVYKLGGRGGMAGWQWLFIVDGVISLPIAIAGFWFIPDVPEIAKPWYLSEEEVKFAQKRMQLEGRQERKPYTKAKFKKILTSWHIYALTPLYVFFNNGGVSAAPVFQQYLKSSKDPKYTVSQINVYPTIQNGVQVGSTLAMAWISDGVLKGARWPMIVFGGCVNIMTEVSLAVWNIPTKWKWACLSLTGVAGGLSGLCMAWAHEICTHDNEERAIVIASMNEVAYVLQAWLPLIVWQQVDAPEYRKGYITVSCLSFMLIVTALTIRVLHAREVAQRQDEEESDASSAQLGREESTEKYVDLKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CC27</accession>
    <name>A0A177CC27_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">POPLD-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_1165517</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG05204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035569.1">
        <property type="nucleotide sequence ID" value="XM_018178731.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CC27"/>
    <dbReference type="FunCoup" id="A0A177CC27">
        <property type="interactions" value="100"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CC27"/>
    <dbReference type="GeneID" id="28762217"/>
    <dbReference type="InParanoid" id="A0A177CC27"/>
    <dbReference type="OrthoDB" id="442863at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005655">
        <property type="term" value="C:nucleolar ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000172">
        <property type="term" value="C:ribonuclease MRP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001682">
        <property type="term" value="P:tRNA 5'-leader removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039182">
        <property type="entry name" value="Pop1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055079">
        <property type="entry name" value="POP1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009723">
        <property type="entry name" value="Pop1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012590">
        <property type="entry name" value="POPLD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22731">
        <property type="entry name" value="RIBONUCLEASES P/MRP PROTEIN SUBUNIT POP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22731:SF3">
        <property type="entry name" value="RIBONUCLEASES P_MRP PROTEIN SUBUNIT POP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22770">
        <property type="entry name" value="POP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06978">
        <property type="entry name" value="POP1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08170">
        <property type="entry name" value="POPLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Pop1 N-terminal" evidence="5">
        <location>
            <begin position="52"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="POPLD" evidence="6">
        <location>
            <begin position="532"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="domain" description="POP1 C-terminal" evidence="7">
        <location>
            <begin position="779"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="71"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="490"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="729"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="20"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="135"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF06978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF22770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAG05204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="846" mass="94157" checksum="91D6E1FF1C739E0A" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CC47</accession>
    <name>A0A177CC47_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">leucine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Leucyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CC84DRAFT_1165544</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>tRNA(Leu) + L-leucine + ATP = L-leucyl-tRNA(Leu) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:11688"/>
            <dbReference type="Rhea" id="RHEA-COMP:9613"/>
            <dbReference type="Rhea" id="RHEA-COMP:9622"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78494"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.4" evidence="2"/>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG05233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035598.1">
        <property type="nucleotide sequence ID" value="XM_018178743.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CC47"/>
    <dbReference type="FunCoup" id="A0A177CC47">
        <property type="interactions" value="1187"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CC47"/>
    <dbReference type="GeneID" id="28762229"/>
    <dbReference type="InParanoid" id="A0A177CC47"/>
    <dbReference type="OrthoDB" id="10249672at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004823">
        <property type="term" value="F:leucine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990825">
        <property type="term" value="F:sequence-specific mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006429">
        <property type="term" value="P:leucyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903432">
        <property type="term" value="P:regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.740.10:FF:000001">
        <property type="entry name" value="Leucine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.740.10">
        <property type="entry name" value="Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004493">
        <property type="entry name" value="Leu-tRNA-synth_Ia_arc/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00395">
        <property type="entry name" value="leuS_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45794:SF1">
        <property type="entry name" value="LEUCINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45794">
        <property type="entry name" value="LEUCYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="ValRS/IleRS/LeuRS editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class Ia" evidence="11">
        <location>
            <begin position="230"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="domain" description="Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding" evidence="12">
        <location>
            <begin position="875"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="167"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1125"/>
            <end position="1165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1130"/>
            <end position="1141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OAG05233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="1165" mass="131081" checksum="75007C80B9D5C074" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CCE1</accession>
    <name>A0A177CCE1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Telomeric single stranded DNA binding POT1/Cdc13 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1164928</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG04467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034832.1">
        <property type="nucleotide sequence ID" value="XM_018178602.1"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CCE1"/>
    <dbReference type="GeneID" id="28762088"/>
    <dbReference type="InParanoid" id="A0A177CCE1"/>
    <dbReference type="OrthoDB" id="5363079at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011564">
        <property type="entry name" value="Telomer_end-bd_POT1/Cdc13"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02765">
        <property type="entry name" value="POT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00976">
        <property type="entry name" value="Telo_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Telomeric single stranded DNA binding POT1/Cdc13" evidence="2">
        <location>
            <begin position="1403"/>
            <end position="1558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="208"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="383"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="580"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="962"/>
            <end position="1128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1142"/>
            <end position="1206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1223"/>
            <end position="1282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1334"/>
            <end position="1390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1567"/>
            <end position="1596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="457"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="649"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="670"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="695"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="721"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="752"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="830"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="863"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1001"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1013"/>
            <end position="1026"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1027"/>
            <end position="1053"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1064"/>
            <end position="1077"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1078"/>
            <end position="1090"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1095"/>
            <end position="1108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1166"/>
            <end position="1176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1180"/>
            <end position="1206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1344"/>
            <end position="1364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1365"/>
            <end position="1378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1567"/>
            <end position="1579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1583"/>
            <end position="1596"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG04467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="1596" mass="172893" checksum="0AC42525BB207B2D" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CDA5</accession>
    <name>A0A177CDA5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1205391</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG05634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035999.1">
        <property type="nucleotide sequence ID" value="XM_018181972.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CDA5"/>
    <dbReference type="GeneID" id="28765458"/>
    <dbReference type="InParanoid" id="A0A177CDA5"/>
    <dbReference type="OrthoDB" id="3799848at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="206"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="126"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="260"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="271"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="333"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="420"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="439"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG05634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="782" mass="85429" checksum="137C25A5825DCB66" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CDB0</accession>
    <name>A0A177CDB0_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mob1/phocein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1218578</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG05211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035576.1">
        <property type="nucleotide sequence ID" value="XM_018183011.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CDB0"/>
    <dbReference type="FunCoup" id="A0A177CDB0">
        <property type="interactions" value="514"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CDB0"/>
    <dbReference type="GeneID" id="28766497"/>
    <dbReference type="InParanoid" id="A0A177CDB0"/>
    <dbReference type="OrthoDB" id="8170117at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.30">
        <property type="entry name" value="MOB kinase activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005301">
        <property type="entry name" value="MOB_kinase_act_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036703">
        <property type="entry name" value="MOB_kinase_act_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22599">
        <property type="entry name" value="MPS ONE BINDER KINASE ACTIVATOR-LIKE MOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03637">
        <property type="entry name" value="Mob1_phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01388">
        <property type="entry name" value="Mob1_phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101152">
        <property type="entry name" value="Mob1/phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="77"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="151"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="13"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="88"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="192"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="270"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="275"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="352"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="357"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR605301-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG05211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="408" mass="45296" checksum="A32FE992378FA5B7" modified="2016-09-07" version="1">MFVPPISNAASHPSPPRFPAQPKPLQPVFTFAQSQSCMYFGMDMFEQADRGDIRDAWAGIGGGVSLLSPQTAYKSPLQRAGKALRTQHAGTSSASSTKNDAAGAVFPAVSTKLFDQMRLPRQRVKQCSTPVYQNYSHKLLPAVQGSSLQLETSGNGYNGSGKGREDCGGIDLVSSPETKAQTEQTEDMGLLSSLSSNPRTQRQPFKPQKSGRGTSSWQLKQYAEATLGSGSLRKAVKLPEGEDKDEWLAVNVVDFYNQINLLYGSITEFCSPQTCPEMKATDEFEYLWQDNEAFKKPTKMSAPEYIEHLMAWIQSNVDNEANFPSRIGVPFPKSFAALIRNMFKRLYRVYAHIYCHHYPVIIELGLEPHLNTSFKHYVLFIDEHGLASGSKDFWGPLGDLVESMLRSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CDB1</accession>
    <name>A0A177CDB1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_802194</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG04767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035132.1">
        <property type="nucleotide sequence ID" value="XM_018187478.1"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CDB1"/>
    <dbReference type="GeneID" id="28770964"/>
    <dbReference type="InParanoid" id="A0A177CDB1"/>
    <dbReference type="OrthoDB" id="3647690at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038609">
        <property type="entry name" value="HDA1_su2/3_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="296"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="380"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="549"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1170"/>
            <end position="1225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1447"/>
            <end position="1491"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1256"/>
            <end position="1290"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1323"/>
            <end position="1392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="82"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="152"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="164"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="186"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="199"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="230"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="296"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="398"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="426"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="439"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="484"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="559"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="593"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="611"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="629"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="651"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="739"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="759"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1210"/>
            <end position="1225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1481"/>
            <end position="1491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG04767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="1491" mass="165100" checksum="F8267F76784F9D2B" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CDZ8</accession>
    <name>A0A177CDZ8_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Copper transport protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CC84DRAFT_1206512</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG04987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035352.1">
        <property type="nucleotide sequence ID" value="XM_018182036.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CDZ8"/>
    <dbReference type="STRING" id="1460663.A0A177CDZ8"/>
    <dbReference type="GeneID" id="28765522"/>
    <dbReference type="InParanoid" id="A0A177CDZ8"/>
    <dbReference type="OrthoDB" id="73901at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005375">
        <property type="term" value="F:copper ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007274">
        <property type="entry name" value="Cop_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12483:SF120">
        <property type="entry name" value="HIGH-AFFINITY COPPER TRANSPORTER CTRA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12483">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 31 COPPER TRANSPORTERS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04145">
        <property type="entry name" value="Ctr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="4" id="KW-0187">Copper transport</keyword>
    <keyword evidence="4" id="KW-0406">Ion transport</keyword>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="9"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAG04987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="195" mass="20937" checksum="3E4428FCD42A78EE" modified="2016-09-07" version="1">MVAHEGHDMSSMAGMDMDGGSSGSSSMGMSMFFFTSTTTPLYSEAWTPASAGAYAGTCIFLIILAILLRALFTAKTFLEYRALQSAMKRRYIVAADQQTATDKAFNDASSMTGILTTNGLQENVRIVEAPARHVQPFRFSVDLPRAAIMTLAAGVGYLLMLAVMTYNVGYFLSVLAGAFIGELALGRFNQSAMSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CE46</accession>
    <name>A0A177CE46_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tetraspanin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_821333</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG05058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035423.1">
        <property type="nucleotide sequence ID" value="XM_018187535.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CE46"/>
    <dbReference type="STRING" id="1460663.A0A177CE46"/>
    <dbReference type="GeneID" id="28771021"/>
    <dbReference type="InParanoid" id="A0A177CE46"/>
    <dbReference type="OrthoDB" id="2279611at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="180"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG05058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="224" mass="24562" checksum="2FBCB5E7C163433B" modified="2016-09-07" version="1">MPTKLMMIFVGLDFVFAGCGGLLLGFSLMSEQRMRESPRVDNVTENLLLGQCPLTGGVVNAVFIFVTFLLSLPALFLPANRGWLRTQGWLVVICATFTLGLGLAVWVDTLQTRAHLGELWQREAPLIQSLLQQKFDCCGYFNSTAPPFVQDGTCINSLVAAQKGGCIGPFSSFANRYLDLIFTAAFGIVGVDALLVLCVAMVLQYRSEQERYRHIDEKNGLGGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CE49</accession>
    <name>A0A177CE49_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Integral membrane protein-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CC84DRAFT_826348</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the peroxisomal membrane protein PXMP2/4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG05079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035444.1">
        <property type="nucleotide sequence ID" value="XM_018187538.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CE49"/>
    <dbReference type="STRING" id="1460663.A0A177CE49"/>
    <dbReference type="GeneID" id="28771024"/>
    <dbReference type="InParanoid" id="A0A177CE49"/>
    <dbReference type="OrthoDB" id="10267969at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007248">
        <property type="entry name" value="Mpv17_PMP22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266:SF80">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN 2, PXMP2 MPV17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04117">
        <property type="entry name" value="Mpv17_PMP22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="171"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAG05079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="191" mass="21025" checksum="FA69AA97D1E5BE49" modified="2016-09-07" version="1">MPSAMVSQTVQGAVLSVTSNILAQALTSYKEDTPFAISLPPILKFAIFSIISNPPNILWQTFLEDTFPSNVPAEPLGKQIKEKSVQTTRTSKRNLVAKFTLDQTIGAVVNTLMFLVYMAYVNDSSAKDNASWSTVQADVSERFWPMIMDGYKFWPAVSLASFLWVPVDKRVVFGCSAGVLWGIYLSLSVAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CEI6</accession>
    <name>A0A177CEI6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CC84DRAFT_1165601</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG05322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035687.1">
        <property type="nucleotide sequence ID" value="XM_018178754.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CEI6"/>
    <dbReference type="STRING" id="1460663.A0A177CEI6"/>
    <dbReference type="GeneID" id="28762240"/>
    <dbReference type="InParanoid" id="A0A177CEI6"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11065">
        <property type="entry name" value="CYP64-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF7">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="461"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="393"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OAG05322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="480" mass="54892" checksum="BC2713C52622849B" modified="2016-09-07" version="1">MPKPGVLECHHWLQHKDLYGPISSVTVLGQTFVIINDSQIAFELLRDRSAIHSSRPGLVFSCDMVGWRHAMAMCPYDDFWKTQRKNVTKISSTTASISVFDRVQEAEAVHFLLNVLDAPEKLFDHIRKEAGSVILKITYGYNTVPRGNDPFVDLATKTMVQFADATTPGRWMVDILPFLRYLPEWVPGTGFKDTARRMAVQLAQCTNQPYQFVKQQMREKRHKTSFLSQCIQDIGSDTEKEFVHKWAALALYLGGADTTVSALMTFFLAMTVFPDVQKKAQEELGRVIGPSRLPVTTDKPSLPYIEACMLETHRWHQVLPMGLPHMSTEEDICRGYRIPKGAILLSNNWHFTHDPAVYPDPMTFRPERFITTATHKAETDPRSFIFGYGRRICPGRYVADNALFITIAQSLAVFEVRKAMEGGKEVEPRVEFEPGAISHPMPFKCDIRPRSERHERLIREAEREYPLEESDAKELENIKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CF43</accession>
    <name>A0A177CF43_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Mannan endo-1,4-beta-mannosidase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_1205199</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 26 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG05377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035742.1">
        <property type="nucleotide sequence ID" value="XM_018181955.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CF43"/>
    <dbReference type="GeneID" id="28765441"/>
    <dbReference type="InParanoid" id="A0A177CF43"/>
    <dbReference type="OrthoDB" id="5286354at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016985">
        <property type="term" value="F:mannan endo-1,4-beta-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006080">
        <property type="term" value="P:substituted mannan metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04086">
        <property type="entry name" value="CBM35_mannanase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005084">
        <property type="entry name" value="CBM6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022790">
        <property type="entry name" value="GH26_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000805">
        <property type="entry name" value="Glyco_hydro_26"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40079:SF4">
        <property type="entry name" value="GH26 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40079">
        <property type="entry name" value="MANNAN ENDO-1,4-BETA-MANNOSIDASE E-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16990">
        <property type="entry name" value="CBM_35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02156">
        <property type="entry name" value="Glyco_hydro_26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00739">
        <property type="entry name" value="GLHYDRLASE26"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51175">
        <property type="entry name" value="CBM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51764">
        <property type="entry name" value="GH26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008058203" evidence="5">
        <location>
            <begin position="19"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="domain" description="CBM6" evidence="6">
        <location>
            <begin position="21"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="GH26" evidence="7">
        <location>
            <begin position="160"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="311"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAG05377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="470" mass="51289" checksum="E807956487C7A073" modified="2016-09-07" version="1">MLVTRACGLVAIAGTILAQTTVYEAESATLNGVTVGTSVAGFSGTGYVEGFDTATDTITFNVSSSASKLYDLSIVYNGPYGDKYTTVVLNNVGGSQVSLPATTNWTTVSAGQVLLNAGSNSIQIQNNWGWYLIDSIKLAPSAKRGAHKVTTTPINKNANSDAKALLKYLGSIYGKKILSGQHDQASLDWVTNNVGKTPAIGGYDFMDYTESRKAHGAVSTDVDKAIAFAKKGGIVTFQWHWGAPTGLYDTADHPWYSGFYTDATDFNIETALKDTTNANYTLLIKDIDTIAIELKKLQAAAVPIIFRPLHEAEGAWFWWGAKGPEPAKKLWNILYDRLTKYHKLNNLIWEWNSVAAAWYPGNDKVDLVSADTYNQGDHGPISATYNSLLALTNDTKIIAAAEIGSVMEPDQLQAYQADWVYFAVWSGDYISGGSWNSLDLLKRIYASDYVLTLDEIQGWKKTTNPRAWEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CFQ2</accession>
    <name>A0A177CFQ2_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Calcofluor white hypersensitive protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_1259632</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG06444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036809.1">
        <property type="nucleotide sequence ID" value="XM_018184926.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CFQ2"/>
    <dbReference type="GeneID" id="28768412"/>
    <dbReference type="InParanoid" id="A0A177CFQ2"/>
    <dbReference type="OrthoDB" id="5355126at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="70"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAG06444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="142" mass="15046" checksum="1E31C0B4676F7660" modified="2016-09-07" version="1">MAGRQVGTLAAVAGLGGIGYYLYSAGGDPKLAEKKLEHDAAEATRKLRGDYPGQDKEAKKAGEEAYETARAKAQSLANDAKAKADKADAELAKYSADAKKKFEELKNETGREVNAAANKFDKEVTDGINKSKGWFGGLFGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CGB4</accession>
    <name>A0A177CGB4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CC84DRAFT_739563</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG05879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036244.1">
        <property type="nucleotide sequence ID" value="XM_018187248.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CGB4"/>
    <dbReference type="STRING" id="1460663.A0A177CGB4"/>
    <dbReference type="GeneID" id="28770734"/>
    <dbReference type="InParanoid" id="A0A177CGB4"/>
    <dbReference type="OrthoDB" id="60033at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43047:SF64">
        <property type="entry name" value="HISTIDINE KINASE CONTAINING CHEY-HOMOLOGOUS RECEIVER DOMAIN AND PAS DOMAIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43047">
        <property type="entry name" value="TWO-COMPONENT HISTIDINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55781">
        <property type="entry name" value="GAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PAS" evidence="9">
        <location>
            <begin position="266"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="7">
        <location>
            <begin position="415"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="8">
        <location>
            <begin position="714"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="6">
        <location>
            <position position="763"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAG05879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="871" mass="96428" checksum="DE3196BB4B272536" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CGC6</accession>
    <name>A0A177CGC6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Oxidoreductase CipA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_1090863</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG05878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036243.1">
        <property type="nucleotide sequence ID" value="XM_018174378.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CGC6"/>
    <dbReference type="STRING" id="1460663.A0A177CGC6"/>
    <dbReference type="GeneID" id="28757864"/>
    <dbReference type="InParanoid" id="A0A177CGC6"/>
    <dbReference type="OrthoDB" id="9974981at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05259">
        <property type="entry name" value="PCBER_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051609">
        <property type="entry name" value="NmrA/Isoflavone_reductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045312">
        <property type="entry name" value="PCBER-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706:SF1">
        <property type="entry name" value="CIPA-LIKE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12460)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706">
        <property type="entry name" value="NMRA-LIKE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="4"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAG05878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="301" mass="32059" checksum="7638D76763F19498" modified="2016-09-07" version="1">MPTHVALAGATGLLGPVILAALLAAEHKVTVLTRVGSMAAEKLPLHPNMSVRQVDLADAGSIIPALGGVSVVISCVAASALDAQNPLIDAAVAAGATRFIPAEYGLDSANPKAVLLPIIREKAATQTHLRAKVRETGGAFSWTAIANGWFLDWVLQSTDILLDVKAKSAVRYNGGDVRFSAALLSDVAHAVVSIIARQDETRDRLVYIHSAVVTQNQLLRYAEEKDGRKWTTSAKGSDELLREIWGAVDRRDLGTAYTLVPILGCSDLEYGCDYSGHDDNELLGIREMSEGEVRGLVEGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CH44</accession>
    <name>A0A177CH44_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Methyltransferase type 11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1241704</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG06893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037258.1">
        <property type="nucleotide sequence ID" value="XM_018184061.1"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CH44"/>
    <dbReference type="GeneID" id="28767547"/>
    <dbReference type="InParanoid" id="A0A177CH44"/>
    <dbReference type="OrthoDB" id="5382952at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="222"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="597"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="805"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="857"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1124"/>
            <end position="1143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1192"/>
            <end position="1247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1473"/>
            <end position="1512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="233"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="250"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="268"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="291"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="314"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="333"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="401"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="438"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="535"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="568"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="597"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="669"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="696"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="721"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="897"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="926"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="964"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1130"/>
            <end position="1139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1209"/>
            <end position="1231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1232"/>
            <end position="1247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG06893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1607" mass="172737" checksum="D283094C72F69C58" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CH58</accession>
    <name>A0A177CH58_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1162931</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG06561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036926.1">
        <property type="nucleotide sequence ID" value="XM_018178128.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CH58"/>
    <dbReference type="GeneID" id="28761614"/>
    <dbReference type="InParanoid" id="A0A177CH58"/>
    <dbReference type="OrthoDB" id="3762150at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG06561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="341" mass="36527" checksum="2919F8028A0904D4" modified="2016-09-07" version="1">MPWVFLDSLVHGAEMIINYAGVIGEAIQAVTNVAQQHKTPEAFGIFDDLGDAFNAATKVISIASQILPPATKPTVADDTSETRIETRAGLFVAPTILTSNGHLGRPMYDALSKNLANMGVPASYVGKDGRTHDSADDIGVAAFANAPFSSAASPSNMPYQTTGFEINNIDDTLNVRGNHAYYAVPLGQDAPSTMWHSATTIAATTTQGFRDNYKRQSGTQTVYNKSLEVAKQGGSATRIVNLNVTWCSQSYAQQIYPTFSTLWKKKMGDTIIYKHPFGTTWQLKIQAAVGASPAQVRAAVEVIAQQSIQQRASSTKAAIQQDPKISPPPAVVVTNSALTYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CI71</accession>
    <name>A0A177CI71_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_610953</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG06682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037047.1">
        <property type="nucleotide sequence ID" value="XM_018186889.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CI71"/>
    <dbReference type="STRING" id="1460663.A0A177CI71"/>
    <dbReference type="GeneID" id="28770375"/>
    <dbReference type="InParanoid" id="A0A177CI71"/>
    <dbReference type="OrthoDB" id="187139at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF46">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="33"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAG06682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="487" mass="54681" checksum="7C7CA0A6AC956BD9" modified="2016-09-07" version="1">MEGSFIRFRLESKHPPVSVTATGSKTKRRTKTGCLTCRTRRKKCDELKPSCVACRRNYFTCRWPDTNSIREEGSSPNASAEKRASWQLTQTSLNPSYILTSQPFGYKARDSYLLEHYVLVTSQQLTGREHKQNPFLELLMPLALQDSRVLEGVLAVSGAHLSFQDQRFESDARSHYAGTVRSVKYTLLAWGMLETHDMIALLTTTLLLGYFESIIGDTRGSVFHHLRASRTILLELQSRRIPDPSHLAFLTEWYAFTAITANVTLHTSFATMDRDIPTDNFLSADALQSLNKGTASYGVLFGAAHKLLALIVPIRDAARRLSHSPDLSAHHEQLHAFEAQIRASNTGVLRAHPTASEVGAAIYHQALLVYLHTTFHGTAPPTPALYATIDPCVDRLFELMRAMRSQSAVITTLMWPALVIGSCVRKEGQQARFSAYMEALPLRMGSCQRVREVLRCMWEARREDERVYGPYGLEIVMGKMNINLCVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CIF7</accession>
    <name>A0A177CIF7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CC84DRAFT_1258452</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG07304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037669.1">
        <property type="nucleotide sequence ID" value="XM_018184831.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CIF7"/>
    <dbReference type="STRING" id="1460663.A0A177CIF7"/>
    <dbReference type="GeneID" id="28768317"/>
    <dbReference type="InParanoid" id="A0A177CIF7"/>
    <dbReference type="OrthoDB" id="4682787at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF146">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="61"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="94"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="136"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="174"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="229"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="261"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="79"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="345"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="418"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="506"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="345"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="367"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="424"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAG07304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="529" mass="58752" checksum="97E65BC76E99C874" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CIY3</accession>
    <name>A0A177CIY3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1163615</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG07463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037828.1">
        <property type="nucleotide sequence ID" value="XM_018178305.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CIY3"/>
    <dbReference type="STRING" id="1460663.A0A177CIY3"/>
    <dbReference type="GeneID" id="28761791"/>
    <dbReference type="InParanoid" id="A0A177CIY3"/>
    <dbReference type="OrthoDB" id="19653at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050466">
        <property type="entry name" value="Carboxylest/Gibb_receptor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23024:SF339">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23024">
        <property type="entry name" value="ARYLACETAMIDE DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="1">
        <location>
            <begin position="50"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG07463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="320" mass="35926" checksum="B7C659752511F440" modified="2016-09-07" version="1">MAPYDDTTAATRFDSFNVYETHFKQIGDHKIKVAILVPKDLKPGKVPLAVKFHGGGLVVGDALFPDWIAAFWVPFMHRNNAITILPNYRLVPESSGADILEDLADFWSWFNDKGVDKYLTSQNVNVDLDYKHLLVSGDSAGGYMALQSGLTRPEGEINAILAQYPMTNHTRRSPEDSMLGMQTPSREWMDEKLASLLTPGAITSSAHPYKTDRFGLSMALNAYGRYNEFFGEGERLWPITAVKSVKFVPPTTIFHALGDSAVKFQDSVDFVERTKSVVPGVEIRLAYGKEGDHGFDGALKEDEEPWLKEELQWVESRWLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CJD3</accession>
    <name>A0A177CJD3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CC84DRAFT_630412</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG06897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037262.1">
        <property type="nucleotide sequence ID" value="XM_018186944.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CJD3"/>
    <dbReference type="STRING" id="1460663.A0A177CJD3"/>
    <dbReference type="GeneID" id="28770430"/>
    <dbReference type="InParanoid" id="A0A177CJD3"/>
    <dbReference type="OrthoDB" id="2017497at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032126">
        <property type="term" value="C:eisosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070941">
        <property type="term" value="P:eisosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072659">
        <property type="term" value="P:protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008253">
        <property type="entry name" value="Marvel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052649">
        <property type="entry name" value="NCE102-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28165:SF2">
        <property type="entry name" value="MARVEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28165">
        <property type="entry name" value="NON-CLASSICAL EXPORT PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01284">
        <property type="entry name" value="MARVEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="74"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="158"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="MARVEL" evidence="6">
        <location>
            <begin position="7"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAG06897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="182" mass="19673" checksum="B9E5A7092A1155BB" modified="2016-09-07" version="1">MTSPILNFAIRGFQVVFAAVVLGLSVGMIKGQGPTLDSPISLRYTAFVGGVTFLTAIVGIAAEWISVLQGMVGLIIDGVVILLNIAGGVLLAIQIGVPKCSDTSPENMLNLYHNHLFNGGCYKKLPKVEGEYQCWNGPFNDREGQLNARCKEAQADTVFLFFTVVILLVSATMTFLRQKKGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CJF7</accession>
    <name>A0A177CJF7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1118155</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG07655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038020.1">
        <property type="nucleotide sequence ID" value="XM_018175512.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CJF7"/>
    <dbReference type="GeneID" id="28758998"/>
    <dbReference type="InParanoid" id="A0A177CJF7"/>
    <dbReference type="OrthoDB" id="2851338at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG07655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="240" mass="26892" checksum="232A43063B929EEE" modified="2016-09-07" version="1">MSATWTGPGIMQALVTLVPDSKLDQDTLEKWFYEVYLPAVLQTGIVQNITAWKAASPGYERQWMIVMEVGDLEMVQYGNRKHVGGGLHEIPRTSEIFPGGGAVDEFVDFESRILERVEVYGEEGSTADDVTTIIYAAMQPAPGGEKDLDAWYREEHNEQMSKEPGYKRTTRYKPLFQTRNSGKGKPGGLDFVAFHQFGEGNKVGTEVEPLDPMTEWTKRCMAGCEKIDAAVYRKVKTLRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CL64</accession>
    <name>A0A177CL64_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">LysM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1216506</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG07569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037934.1">
        <property type="nucleotide sequence ID" value="XM_018182812.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CL64"/>
    <dbReference type="STRING" id="1460663.A0A177CL64"/>
    <dbReference type="GeneID" id="28766298"/>
    <dbReference type="InParanoid" id="A0A177CL64"/>
    <dbReference type="OrthoDB" id="2281372at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008058426" description="LysM domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG07569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="180" mass="19446" checksum="EEF031EB1D7B73AA" modified="2016-09-07" version="1">MKFLVALALAVSPLLSAAYTVDPPTTAAPDTIEDCTLWAVATSTSTCADLIEQGYALTLDQFNAYNPSQAAACNLTVGQSYCIEKNWSIPDPLPTSTSSAAPGPTGPVTDPATLLAVCRAQGSYVEYCERCLYHCQYETTYIEMCFDSIFGLINRYDSDCWQHGGRDCANQAADRVCPKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CLJ2</accession>
    <name>A0A177CLJ2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Quinate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1141049</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038748.1">
        <property type="nucleotide sequence ID" value="XM_018176308.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CLJ2"/>
    <dbReference type="STRING" id="1460663.A0A177CLJ2"/>
    <dbReference type="GeneID" id="28759794"/>
    <dbReference type="InParanoid" id="A0A177CLJ2"/>
    <dbReference type="OrthoDB" id="204377at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004764">
        <property type="term" value="F:shikimate 3-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019632">
        <property type="term" value="P:shikimate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01065">
        <property type="entry name" value="NAD_bind_Shikimate_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10860">
        <property type="entry name" value="Leucine Dehydrogenase, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013708">
        <property type="entry name" value="Shikimate_DH-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022893">
        <property type="entry name" value="Shikimate_DH_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21089:SF1">
        <property type="entry name" value="BIFUNCTIONAL 3-DEHYDROQUINATE DEHYDRATASE_SHIKIMATE DEHYDROGENASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21089">
        <property type="entry name" value="SHIKIMATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08501">
        <property type="entry name" value="Shikimate_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Shikimate dehydrogenase substrate binding N-terminal" evidence="1">
        <location>
            <begin position="22"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG08383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="314" mass="34640" checksum="8A08E46FE0F92EF4" modified="2016-09-07" version="1">MAAQQQEIKDSRLDTVERHGYLFGHPIAHSLSPLLHQTIYDGIGLPWSQFPLDSTDMDLFLRLREDPRFYGAAVTMPHKVAILPHLDVLTPEARAVGAVNTLFLRQDASGKRLFCGTNTDVVGIRDSFYANVSDPDASFHGRPALVVGGGGAARSAVYALRTWMKASKVYLVNRDREEVRAVIEECTARGYGDDLIDVSTVAQASALEGVGAIVACVPNFTPKTAAEKEARAVLECFLHKEHKGAILEMCYHPSPWTEIAEISQREGWKVVLGTEAMIYQGLEQDKYWTGREVGEMPVQKVMEVIAGKLSEARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CLX8</accession>
    <name>A0A177CLX8_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PPP4R2-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_716246</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PPP4R2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG07787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038152.1">
        <property type="nucleotide sequence ID" value="XM_018187138.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CLX8"/>
    <dbReference type="STRING" id="1460663.A0A177CLX8"/>
    <dbReference type="GeneID" id="28770624"/>
    <dbReference type="InParanoid" id="A0A177CLX8"/>
    <dbReference type="OrthoDB" id="341898at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030289">
        <property type="term" value="C:protein phosphatase 4 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015267">
        <property type="entry name" value="PPP4R2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16487">
        <property type="entry name" value="PPP4R2-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16487:SF0">
        <property type="entry name" value="PROTEIN PHOSPHATASE 4 REGULATORY SUBUNIT 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09184">
        <property type="entry name" value="PPP4R2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="41"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="238"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="322"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="241"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="380"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="391"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG07787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="410" mass="43559" checksum="79A9351EB99E07AE" modified="2016-09-07" version="1">MASSAAEKVLQKAAEDGSLDAADWPDTLKYILDRLDEIVADFPKPPESGSASVPHTPSRQQPQGSSQESHSGDKENAAPKTPVRPPVPGFTNTESQLPSEAVTFYSSIRNALSTNFPKGAPHTIQRLAELVLEPKRRYKFLMSYLKALDRVVSVSSSNTIFPLPQAVLPTATGLLNGTTATNATQASLGSDESLGGALLTPIPWLQNRGQNELISESTEMVDGPNGTGRIETVTVGMLSGATGSNGSPQATSPTNSNGVSQIASSHPDGETLPSTGPVTQGEILRQEQEAGIVLNNPHSLTTNLSRNTVGEMESGGTVMDTVEGEEEQPHARGPELIGMEDTGPQTQSSRLDIEGAVGRPSIDRSSRSPQPVPEPKDEEMKDENEKDDDTEGNKVQEDDKDGDAEMKTLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CM59</accession>
    <name>A0A177CM59_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1161996</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG07958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038323.1">
        <property type="nucleotide sequence ID" value="XM_018177880.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CM59"/>
    <dbReference type="GeneID" id="28761366"/>
    <dbReference type="InParanoid" id="A0A177CM59"/>
    <dbReference type="OrthoDB" id="3792198at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="253"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="253"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="266"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="316"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="346"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG07958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="357" mass="39442" checksum="42566DA55CA9277A" modified="2016-09-07" version="1">MDFYLPSRSHFFQPAPGVTWMPGRPTGKPRRCGHLSHNSIAKDAYWEAITAGATADEALEKGIEAVEAFLRAKREKKEKKEPTPEPTPEPVDLGPHPSGSKTMEHGQDLPVGAYWKKQVRYDEFAWRCDINHALGRYYLAGDVKSCPGCGSCRSGPGQHPEMDFYLPSGTIARQEAPGLVNYKPRKAYKLTKKSKKAKQIVTHNQFCSKKYWELIEEGHEHCEGGVNEDALALAVKMTDAYVDAKVAAMQAKLEESGSSDEERPMAKSKGKRKQSGKHKEPQSESDSSVRRGRVGAGVFSTTSSTPLVPRKRGSEELNDSELDEVTEYESTKDDEEVQQGTISLSSDDESTSDSDSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CME3</accession>
    <name>A0A177CME3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1257507</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039070.1">
        <property type="nucleotide sequence ID" value="XM_018184739.1"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CME3"/>
    <dbReference type="GeneID" id="28768225"/>
    <dbReference type="InParanoid" id="A0A177CME3"/>
    <dbReference type="OrthoDB" id="6365728at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23159">
        <property type="entry name" value="CENTROSOMAL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23159:SF31">
        <property type="entry name" value="CENTROSOME-ASSOCIATED PROTEIN CEP250 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="229"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1053"/>
            <end position="1089"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1521"/>
            <end position="1949"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="916"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1139"/>
            <end position="1230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="93"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="133"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="176"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="187"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="255"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="293"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="321"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="356"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="402"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="449"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="467"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="528"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="560"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="577"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="614"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="636"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="707"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="726"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="788"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="810"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="850"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1066"/>
            <end position="1089"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1523"/>
            <end position="1534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1536"/>
            <end position="1552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1579"/>
            <end position="1593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1608"/>
            <end position="1624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1625"/>
            <end position="1641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1731"/>
            <end position="1742"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1790"/>
            <end position="1803"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1805"/>
            <end position="1815"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1833"/>
            <end position="1847"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1848"/>
            <end position="1857"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1900"/>
            <end position="1914"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG08705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="1949" mass="212713" checksum="E40E823F2E76D56C" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CMK6</accession>
    <name>A0A177CMK6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CC84DRAFT_1204042</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039130.1">
        <property type="nucleotide sequence ID" value="XM_018181875.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CMK6"/>
    <dbReference type="STRING" id="1460663.A0A177CMK6"/>
    <dbReference type="GeneID" id="28765361"/>
    <dbReference type="InParanoid" id="A0A177CMK6"/>
    <dbReference type="OrthoDB" id="1577640at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050897">
        <property type="term" value="F:cobalt ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015087">
        <property type="term" value="F:cobalt ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045863">
        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46494">
        <property type="entry name" value="CORA FAMILY METAL ION TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46494:SF1">
        <property type="entry name" value="CORA FAMILY METAL ION TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="356"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="399"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAG08765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="436" mass="50396" checksum="743046284AA16054" modified="2016-09-07" version="1" fragment="single">MDSYLHRGLPRAMMEKGKVIRLDITSSQSCQSHEITWDELLQGLRAAPVQVIFTSTNSFLSTVPGFQKELKSTLKIHQFFFDRIYLQSNGFCGHEVWLDDNEKVECYTYWSRFTVKQTYDKLRAKRTYTPHISNHHSGAGDWNADVAIHGPQSVRHGWEWYEMGFFASWTPSGSITLLCFDLPVTLEKDIQSMFCSQGVSRWCPYAVFSLVSDALLRLYDDSVWTVRNHISQWEARRSQEADYILLHEIARHGIHISETLSVAIRSLDAMQHHHAKFRTYNDLVRSKKGCENWDRVGTHFEFQLRFLQGLFQRSEANNARIQNEITLAFNVAAQRDSRIQLQIGEEAKREASAMKAIAVVTMTFLPATFISTIFGSNFFSFEPDGGAGQPSFTVSHQFWIYWALSVPLTAVTLALWFWWSRWVEHLRLSRFRAVAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CMS4</accession>
    <name>A0A177CMS4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_563605</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038617.1">
        <property type="nucleotide sequence ID" value="XM_018186707.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CMS4"/>
    <dbReference type="GeneID" id="28770193"/>
    <dbReference type="InParanoid" id="A0A177CMS4"/>
    <dbReference type="OrthoDB" id="3799120at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG08252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="334" mass="37306" checksum="36BADECACAD0224A" modified="2016-09-07" version="1">MILLSIMSSFNPPSTRTYTKDQWRLDKIVNRERETYELVSTNMPHADSQVLAGGRIALAPRCRASLLEDTHVPPAKDLKQDHRSKIDCPASAPDDFLALFFSRLPQELRDLVYTFVHKWHNWPHQPTKDIIIQPPYLFLSHACTIPSKTSPYSPIPPRLHLSPHPDSPLLARLLHDITASFFATHTFWARYRYTPALHAFLSTPFENSGVVPGDCLRRLGMLLGPPDSAEDSWGLDDEESEYGWERMFPAARNGRCAMWRGQLEGDFTGLGRVFGGDGGGGGVGDEDGSREAREVEVYLMDGYSGDISGVEAWLGEWVEGVNGRGGRVGTSRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CN42</accession>
    <name>A0A177CN42_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative TrkA-N domain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1141540</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the avfA family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039016.1">
        <property type="nucleotide sequence ID" value="XM_018176328.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CN42"/>
    <dbReference type="STRING" id="1460663.A0A177CN42"/>
    <dbReference type="GeneID" id="28759814"/>
    <dbReference type="InParanoid" id="A0A177CN42"/>
    <dbReference type="OrthoDB" id="419598at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004074">
        <property type="term" value="F:biliverdin reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042602">
        <property type="term" value="F:riboflavin reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051606">
        <property type="entry name" value="Polyketide_Oxido-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43355">
        <property type="entry name" value="FLAVIN REDUCTASE (NADPH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43355:SF2">
        <property type="entry name" value="FLAVIN REDUCTASE (NADPH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-binding" evidence="2">
        <location>
            <begin position="7"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG08651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="219" mass="23614" checksum="F392EE30EB41C111" modified="2016-09-07" version="1">MQVLVIGGSGRTGKLVINELLERGHKVTALARNPASLEDRLNLQIVQGTPMNKDDVRAVVKVGKPSVVVVTLSAPRASDSPFAAVASPPRLMADSNANVVAVMKEFNIPKIVIMQAFGVGDSWPNMHCVLRLLMKKSNMIYQYDDHNLVDQEVRASGVNYVLVRPSRLEEGEARPVKEWPGAGKGVPLMGACTRATAAKFLVDAAESTTWDNTAPVITS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CP03</accession>
    <name>A0A177CP03_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cytochrome P450 monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CC84DRAFT_1257464</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039013.1">
        <property type="nucleotide sequence ID" value="XM_018184735.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CP03"/>
    <dbReference type="STRING" id="1460663.A0A177CP03"/>
    <dbReference type="GeneID" id="28768221"/>
    <dbReference type="InParanoid" id="A0A177CP03"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd20615">
        <property type="entry name" value="CYP_GliC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF235">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE APDB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0349">Heme</keyword>
    <keyword evidence="4 5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="2 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="449"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAG08648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="505" mass="57673" checksum="8BB9D8F9E88564AA" modified="2016-09-07" version="1">MIISTLLALQCAGSISIFLISIFRKQVANFIQRVISTVLNAYLARRYAIKNVDDRSNLPSCTYEWPNGQGDKAKFLEGHRNSELWEAKFGAIYRLCVVTKSEHVRAVFKDSDKHMKAVNNNSGHMLGELLGQCVGLISQNQWKRVRSIMDKPFHRSMATTYIPTIKTRTDSFFQELWNDRGLARGLLDPAEDLKLLPFLVVAEVIYGRLTPDVEAELRALAPQRESLMRTVIKGGLTRFYWAQYLPTQANRDLAAFQKRWLAFNELAHSRAVEGKLNAPIIDFFAARDAGKITTKELLHTLDEMLYANLDVTIGAVSWNVVFIAAYPGIQTRLRQEVAEKRRKADEMGVEFEPYLHDGSTLLAACVNESARLRPLAAFSVPQGIPTSRVIGGFKFPAGTNFVVDSYALNIRNPFWGEDRAKYIPDRFLAQERTNARYHYWRFGFGPRVCLGQFVADVLIRTMLLHLVDSYDLEMTKSEAMEDWQRNPQVWINHPNMRLVCTKRNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CP68</accession>
    <name>A0A177CP68_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">COP9 signalosome complex subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CC84DRAFT_1085988</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="4">Component of the COP9 signalosome (CSN) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CSN4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039073.1">
        <property type="nucleotide sequence ID" value="XM_018174134.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CP68"/>
    <dbReference type="STRING" id="1460663.A0A177CP68"/>
    <dbReference type="GeneID" id="28757620"/>
    <dbReference type="InParanoid" id="A0A177CP68"/>
    <dbReference type="OrthoDB" id="295656at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008180">
        <property type="term" value="C:COP9 signalosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000190">
        <property type="entry name" value="COP9 signalosome complex subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054559">
        <property type="entry name" value="PSMD12-CSN4-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040134">
        <property type="entry name" value="PSMD12/CSN4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10855">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 12/COP9 SIGNALOSOME COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10855:SF2">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22241">
        <property type="entry name" value="PSMD12-CSN4_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0736">Signalosome</keyword>
    <feature type="domain" description="PCI" evidence="9">
        <location>
            <begin position="197"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAG08708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="417" mass="46463" checksum="AF96F533D3B9CCFE" modified="2016-09-07" version="1">MASSQVDSALQEIQAAPVGDKPSRYSALLQQITASSSNLAADLNAYSRTLLDDNLGVVVLRPLVSHFVEQFRNIKDPEVKIEVGENVIALLQTKGVGQYEEQDTLIKEAVAEACEETDDYRKSARVLGSINLESTQRSLTNDDKAKVWIRIVRCYLEEDDPTSALLHLNKIKNIIYSVQDKETRIHFQLSQARINDSQRNFLDAAKAYYSLSLESSIAEEERHQALSSAIVCAVLSPAGPPRSKMLATLYKDDRASSVENYSVLEKMFFDRLIPPHETKAFAAGLQPHHLALTSDGSTVLDQAVLQHNLVGASKLYNNIGFDQLGELLGIDAEKAEDYAAKMFEQGRLSGYIDQIDRCIFFEGEGSGERKTGQSERVVGRELRKWDANVQGLAEEVERVTTMIQTQYPEFYAAQTVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CP71</accession>
    <name>A0A177CP71_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative salicylate hydroxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CC84DRAFT_1194726</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038942.1">
        <property type="nucleotide sequence ID" value="XM_018181364.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CP71"/>
    <dbReference type="STRING" id="1460663.A0A177CP71"/>
    <dbReference type="GeneID" id="28764850"/>
    <dbReference type="InParanoid" id="A0A177CP71"/>
    <dbReference type="OrthoDB" id="1047367at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000201">
        <property type="entry name" value="Salicylate hydroxylase protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050493">
        <property type="entry name" value="FAD-dep_Monooxygenase_BioMet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789:SF172">
        <property type="entry name" value="HYDROXYLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12410)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="13"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAG08577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="451" mass="49816" checksum="05DD3B2A4984FBE4" modified="2016-09-07" version="1">MPGTIIEGGWRRLSVAVIGGGIGGLSVAIALRRAGHDVTIYERNDFAGEAGASVSCAANGTRWLHEWGVDVQKGDPVVLKKLINRDWKTGDPVSVYDLDDYEERWGYVYNMFHRQYMHKMLMDCALQEEGAGAPVQLLVNHPCQNIDLESGEITFTNGIKAKHDLIVGADGIGSVTRKIIGLNPDKKPADSSCLHANVLSKDARKLGLVDYSLNSALEYWGGQEGKWDKIVLSPCNGGELLSYYCFFPRSVGDYSNHTWGGADLPVEELTEKYPELDAQVKAHLAIGIEVQPWRLWVHQPYPYLVKSNVCLLGDAGHPMMPHQSQGACMAIEDAAALGILFNKDYFKGDVKESLAVYEQIRLPRVTKVQASAAKAAYNINERIGFSSNTSIKGYKVEDESNKLTIEEMNGYDMYKDIDQAFAERRGVPYTDRYTKGLPFGLKLSNGVTVGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CP76</accession>
    <name>A0A177CP76_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_583856</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038954.1">
        <property type="nucleotide sequence ID" value="XM_018186770.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CP76"/>
    <dbReference type="GeneID" id="28770256"/>
    <dbReference type="InParanoid" id="A0A177CP76"/>
    <dbReference type="OrthoDB" id="10445239at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG08589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="168" mass="18985" checksum="2767E1E5D0DD49B8" modified="2016-09-07" version="1">MWKDFLLNIEPHLDGLFGGVSDLRKLQHGYLTACGTNYSPRGAFFRLVSSLLLSVHYMRICHVRYRYLVLLSLFQGVFLSGSGEEMRSMDAGKRRSVLVVVLAGKGAVGRWWHKHACGWVVSSWIGFKFRIAVMGRSGKFCWRCGGLQMDLGGLRWFVSSVLFHGPLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2023-06-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CPA0</accession>
    <name>A0A177CPA0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_584319</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038984.1">
        <property type="nucleotide sequence ID" value="XM_018186773.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CPA0"/>
    <dbReference type="GeneID" id="28770259"/>
    <dbReference type="InParanoid" id="A0A177CPA0"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG08619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="118" mass="12932" checksum="453FD9563CA64BDE" modified="2016-09-07" version="1">MVSAVRWLGWADRSCRIRTGVFAGMLGCSSTRSTSNHETQYLLSSESLSVALLLERTVNELRQVPTASLYTSCASHLLVYTPPRYSTPALCHPPAFVQTGHRCAAIVCQRESPCDTQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CPZ4</accession>
    <name>A0A177CPZ4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative polysaccharide export protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1183705</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG09301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039666.1">
        <property type="nucleotide sequence ID" value="XM_018180703.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CPZ4"/>
    <dbReference type="STRING" id="1460663.A0A177CPZ4"/>
    <dbReference type="GeneID" id="28764189"/>
    <dbReference type="InParanoid" id="A0A177CPZ4"/>
    <dbReference type="OrthoDB" id="262547at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021047">
        <property type="entry name" value="Mannosyltransferase_CMT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34144">
        <property type="entry name" value="CHROMOSOME 8, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34144:SF7">
        <property type="entry name" value="EXPORT PROTEIN (CAP59), PUTATIVE (AFU_ORTHOLOGUE AFUA_7G05020)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11735">
        <property type="entry name" value="CAP59_mtransfer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG09301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="399" mass="44868" checksum="CFF75AE61185BC07" modified="2016-09-07" version="1">MYFRRHRKAIVRILLALFVLFNALDILHVRQRLARGSPSSNDYEPGSERVFIAGIFWNNEAILRSSLSAALVGLAETLGPKNVFVSIHESGSWDDTKDALRELDEALEKVGVERRITTSNVTHEDEISVEPTGEGWVETPQGNKELRRIPYLAKQRNTGLKPLAELAEKGIHFDKILFVNDVVFSTEDVLQLLNTRGGRYAAACSMDFKIPPYFYDTFALRDSSGHEHLMPTWPYFRSRTSREAIMNNDPVPVASCWNGIVAMPAQIFTGTSPIRFRGIPDSLAATHLEGSECCLIHADNPLSLTEGVFVNPAVRVGYTREAYEAMKAGERGLSSLALLYRLWENRVRRWVTVTPALKSGVVASRVRKWKEGDPKNEEPGSFCLINEMQVLRKIGWAHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CQA9</accession>
    <name>A0A177CQA9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1085846</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG09138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039503.1">
        <property type="nucleotide sequence ID" value="XM_018174123.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CQA9"/>
    <dbReference type="GeneID" id="28757609"/>
    <dbReference type="InParanoid" id="A0A177CQA9"/>
    <dbReference type="OrthoDB" id="5380370at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="183"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="255"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="367"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="481"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="278"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="367"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="500"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG09138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="509" mass="57457" checksum="B6E310B867AE4B0C" modified="2016-09-07" version="1">MKKKAKVVPPCSHAEFESLPEPLRRKYFSSLERLRIAEEHALHEQQGEHKHQYHPFQARPSRSRSTAIHRSILPLGSSRRRLARAESLKHDHYVAQADASFFLSLPPKVQRSAFSREEQTILVGRCEIPPSTTGSPLPPARRTHLHYDEEQRFSDFHFGFNNDGSDDHALARDHDHNHYGAALHRGRSLRRRSSVSSADISPTRGSPYSPAQELDADTEGSLLYLDTMSPVASHPSRASFRRTLSLTNIPLRSSISSAPLAPEPLSARGTAPWHQRAHSQSVSGRRSSHTPQAPVFDPEATHYRDAETRKKLQFLASPQKFDEAVEFGFPSSGDDTMPPRYQLPPISTDARNFSRDVQSFLKDDRMSFLDDHEEEDNKGLESDAESVADFESPVTPSSVGHSFRYHRKQSSNFSSSIDSNGVPLIHPVTGRLNREMTLRMTLTRPDLRADEEQLYGWQGQKHTKDDPFALEDLPLSDDMNGTKGPFYVKPKPHGNLVSRLFKRSSKKGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CRA5</accession>
    <name>A0A177CRA5_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ER-golgi trafficking TRAPP I complex 85 kDa subunit-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1111962</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040419.1">
        <property type="nucleotide sequence ID" value="XM_018175304.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CRA5"/>
    <dbReference type="FunCoup" id="A0A177CRA5">
        <property type="interactions" value="36"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CRA5"/>
    <dbReference type="GeneID" id="28758790"/>
    <dbReference type="InParanoid" id="A0A177CRA5"/>
    <dbReference type="OrthoDB" id="203724at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990072">
        <property type="term" value="C:TRAPPIII protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024420">
        <property type="entry name" value="TRAPP_III_complex_Trs85"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12975:SF6">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12975">
        <property type="entry name" value="TRANSPORT PROTEIN TRAPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12739">
        <property type="entry name" value="TRAPPC-Trs85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="739"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="29"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="752"/>
            <end position="764"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG10054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="764" mass="84331" checksum="99E64AF33D760EE9" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CRF7</accession>
    <name>A0A177CRF7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA helicase</fullName>
            <ecNumber evidence="4">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CC84DRAFT_1193670</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DNA2/NAM7 helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="4"/>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040470.1">
        <property type="nucleotide sequence ID" value="XM_018181319.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CRF7"/>
    <dbReference type="FunCoup" id="A0A177CRF7">
        <property type="interactions" value="544"/>
    </dbReference>
    <dbReference type="GeneID" id="28764805"/>
    <dbReference type="InParanoid" id="A0A177CRF7"/>
    <dbReference type="OrthoDB" id="6513042at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18044">
        <property type="entry name" value="DEXXQc_SMUBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000326">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050534">
        <property type="entry name" value="Coronavir_polyprotein_1ab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048761">
        <property type="entry name" value="SMUBP-2_HCS1_1B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43788:SF8">
        <property type="entry name" value="DNA-BINDING PROTEIN SMUBP-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43788">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21138">
        <property type="entry name" value="SMUBP-2_HCS1_1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="15" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-0347">Helicase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="14">
        <location>
            <begin position="208"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="13">
        <location>
            <begin position="226"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="543"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="551"/>
            <end position="562"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OAG10105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="717" mass="78743" checksum="B41D699EA05FBC98" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CSA4</accession>
    <name>A0A177CSA4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CC84DRAFT_1193393</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG09657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040022.1">
        <property type="nucleotide sequence ID" value="XM_018181294.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CSA4"/>
    <dbReference type="GeneID" id="28764780"/>
    <dbReference type="InParanoid" id="A0A177CSA4"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000078">
        <property type="entry name" value="MFS maltose transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF41">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="36"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="151"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="185"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="216"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="303"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="338"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="371"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="399"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="433"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="468"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="39"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="264"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAG09657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="520" mass="56884" checksum="536CCFC79A8811BE" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CSJ5</accession>
    <name>A0A177CSJ5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1172629</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040536.1">
        <property type="nucleotide sequence ID" value="XM_018179991.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CSJ5"/>
    <dbReference type="GeneID" id="28763477"/>
    <dbReference type="InParanoid" id="A0A177CSJ5"/>
    <dbReference type="OrthoDB" id="3792663at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="493"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="542"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="643"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="501"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="661"/>
            <end position="671"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG10171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="697" mass="76326" checksum="F78BB80CFCD16A2F" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CSM0</accession>
    <name>A0A177CSM0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_1160990</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0057 (PMP3) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG09968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040333.1">
        <property type="nucleotide sequence ID" value="XM_018177630.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CSM0"/>
    <dbReference type="GeneID" id="28761116"/>
    <dbReference type="InParanoid" id="A0A177CSM0"/>
    <dbReference type="OrthoDB" id="2802411at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000612">
        <property type="entry name" value="PMP3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21659">
        <property type="entry name" value="HYDROPHOBIC PROTEIN RCI2 LOW TEMPERATURE AND SALT RESPONSIVE PROTEIN LTI6 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21659:SF57">
        <property type="entry name" value="PLASMA MEMBRANE PROTEOLIPID 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01679">
        <property type="entry name" value="Pmp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008058540" evidence="7">
        <location>
            <begin position="21"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="113"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="114"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="150"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="180"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAG09968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="189" mass="20096" checksum="2755D3557E37753F" modified="2016-09-07" version="1">MCGTDCFLMFLSFLFPPIGGECQAPAAPSCATLFSSLLTVQTVWVKKGICSADSIINLALCCLGVLPGMIHAWYVILNNPEHTYEHVPDHERQDGSRIATYYYVSHGGPAPQGGQMNYGTVGSQPNAGQFPGQQTGTTNAFPQPNKQKNAQTQQGVAGQEVGAGEGSSEQAPPPTYAEVIKGDHKVQKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CT88</accession>
    <name>A0A177CT88_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">Protoheme IX farnesyltransferase, mitochondrial</fullName>
            <ecNumber evidence="12">2.5.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11 12">Heme O synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CC84DRAFT_1161362</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 12">Converts protoheme IX and farnesyl diphosphate to heme O.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the ubiA prenyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.-" evidence="12"/>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040776.1">
        <property type="nucleotide sequence ID" value="XM_018177712.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CT88"/>
    <dbReference type="FunCoup" id="A0A177CT88">
        <property type="interactions" value="803"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CT88"/>
    <dbReference type="GeneID" id="28761198"/>
    <dbReference type="InParanoid" id="A0A177CT88"/>
    <dbReference type="OrthoDB" id="5211at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008495">
        <property type="term" value="F:protoheme IX farnesyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006784">
        <property type="term" value="P:heme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd13957">
        <property type="entry name" value="PT_UbiA_Cox10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.357.140:FF:000004">
        <property type="entry name" value="Protoheme IX farnesyltransferase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="entry name" value="UbiA prenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006369">
        <property type="entry name" value="Protohaem_IX_farnesylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016315">
        <property type="entry name" value="Protohaem_IX_farnesylTrfase_mt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01473">
        <property type="entry name" value="cyoE_ctaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43448">
        <property type="entry name" value="PROTOHEME IX FARNESYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43448:SF2">
        <property type="entry name" value="PROTOHEME IX FARNESYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001773">
        <property type="entry name" value="COX10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="10 12 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="172"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="206"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="250"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="278"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="395"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="444"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="88"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="102"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR001773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OAG10411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="509" mass="56409" checksum="E447560FF74B0905" modified="2016-09-07" version="1">MGFRAPPIRSILTQDTSSVCSQCWRKLLRRPTPCRQPFSNMSSSRHAVAVGKRRNSFSKDYFWTNSTLRETLGQSLARSRRDIQSSIASARVGTAAPARSPEQPEHAETSEDVLPHRRRKRRRELESTENTEQSYPIALDASAQLADISSKLPQRSLKRVFTTYLSLSKPRLSFLVVLTATAAYSLYPVPGLLAPAATATPSLSTLTLFFLTSGTALCSASANAFNMLMEPEHDAKMSRTRNRPLVRKLISTRGAMVFAVACGALGTGALYYGVNPTTAFLGFTNIVLYAGCYTPLKRMHVLNTWIGAIVGGIPPLMGWTAAAGQCAHDGTWQELLFGENSAGGWLCAALLFAWQFPHFNSLSWSIREEYKYAGYRMLAWVNPAQNGRVALRYAVLMFPVCIGLSLCGVTDMSFIATSSVVNGWMVWKAVDFWREQGHKGTARGLFWASVWHLPIVMVLAMAQKKGLGERVYRSIFGYADDEDDLYYEVGQFEEEEEKVKAVVERGSTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CTC5</accession>
    <name>A0A177CTC5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cell division cycle protein-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_495120</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CDC123 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041150.1">
        <property type="nucleotide sequence ID" value="XM_018186520.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CTC5"/>
    <dbReference type="FunCoup" id="A0A177CTC5">
        <property type="interactions" value="743"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CTC5"/>
    <dbReference type="GeneID" id="28770006"/>
    <dbReference type="InParanoid" id="A0A177CTC5"/>
    <dbReference type="OrthoDB" id="360540at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044183">
        <property type="term" value="F:protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905143">
        <property type="term" value="P:eukaryotic translation initiation factor 2 complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009772">
        <property type="entry name" value="CDC123"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15323:SF6">
        <property type="entry name" value="CELL DIVISION CYCLE PROTEIN 123 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15323">
        <property type="entry name" value="D123 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07065">
        <property type="entry name" value="D123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="75"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="75"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG10785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="388" mass="44607" checksum="E0FFD2345F5312C9" modified="2016-09-07" version="1">MSTEHADSEASVVAASPDQPKQLPFPPVTKQHILNCSYHSWHPKYRAITPKARLVPLPGAFLDYLRADGIVLPPEDNDNPDWSDADSGIFSGADNEGDDEGPDQDPSTHWRDTHEAIEAVIEELGGKVAPKLNWSAPKDATWIAATNSMECRTPNDIYLLLKSSDFITHDLQHALDDTTDGEGDAEIQYHLVLRKWIVLNPSVEFRCFVRNRKLIAICQRDLNHFDFLFKMEDKLRQTVQEFFDVRLRDTFPDPNFTFDVYIPPPHDRVWLVDFNPWALRTDPLLFSWMELLTLEEPLLPEAEDASQEFEVDEDDKVVELWQPEFRLVRRDDPEAYGFSTPQYSAHKLPRDVVDASRGGEGMMREFADQWKEAQRLAEQQAKEESEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CTT9</accession>
    <name>A0A177CTT9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1084719</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041310.1">
        <property type="nucleotide sequence ID" value="XM_018174064.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CTT9"/>
    <dbReference type="STRING" id="1460663.A0A177CTT9"/>
    <dbReference type="GeneID" id="28757550"/>
    <dbReference type="InParanoid" id="A0A177CTT9"/>
    <dbReference type="OrthoDB" id="27483at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33099">
        <property type="entry name" value="FE2OG DIOXYGENASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33099:SF7">
        <property type="entry name" value="MYND-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="2">
        <location>
            <begin position="154"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG10945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="458" mass="50150" checksum="A6D787C5D42A8F81" modified="2016-09-07" version="1">MSSIKTALTDAISAELGSFIVSKSSTFACGGTIPIQGVSDTPGDLKPAGITFPFALRWDSKYSATGVGKLTFPVDPTNTMEMQNFSKLLEECEPASFGYKGEDVLDETYRKATKLDRSAFSVDFCPYELGIIDRIAQILLPNAKSDDGAHIGSSTHGVRAELYKLNIYGAPSGFFKSHVDTPRSDLQFGSLVVSLPCHYEGGQLIVRHAGHSMTFDWGASELVNTSVQWAAFYSDCEHEVLEVTEGNRVTLTYNLFYTSDIGELVGNGPTMSVKSLPLHSKIQEALDNPDFMSNGGYLGIHCQHAYAHSTKEGAQQLPGVLKGSDMAVYSVFQSLRLEIEVKSVLDSQNGLFRDQYRYYDDSDETTRKKDLSYIRRLGEVVVTETGGYEEPLQEIIDEFGDAVDVLWLTQPRHANVGMVHLTYGNQAGINAIYTYAALIVNIPKAAIRGRASDAASFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CTY6</accession>
    <name>A0A177CTY6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1084743</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040747.1">
        <property type="nucleotide sequence ID" value="XM_018174066.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CTY6"/>
    <dbReference type="GeneID" id="28757552"/>
    <dbReference type="InParanoid" id="A0A177CTY6"/>
    <dbReference type="OrthoDB" id="3735750at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG10382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="169" mass="19476" checksum="C71856DCA65573D1" modified="2016-09-07" version="1">MSWNYTVNQINLSFERIAQWYQDFLRRSEAAFRALHDRVLVLEQQQASQGPSDEQVERVLRKILAERFGDTSSLRVENPSQIKDVDFFVKPPDDNIPIPRAPLIDPAMLFVDPEAVPSKAYSETFQMLERGLSQYPQIDDAKPVIRDATPKEEDDFKPPGLPPNHGRPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2024-01-24" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CU29</accession>
    <name>A0A177CU29_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fungal N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1213833</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040883.1">
        <property type="nucleotide sequence ID" value="XM_018182572.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CU29"/>
    <dbReference type="STRING" id="1460663.A0A177CU29"/>
    <dbReference type="GeneID" id="28766058"/>
    <dbReference type="InParanoid" id="A0A177CU29"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG10518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="150" mass="16306" checksum="4F3003F417A60B3D" modified="2016-09-07" version="1">MADPLSVVASSFAVVGVADVVLRACLKCHKLLADIEDAPASIEGLKTSLRNNTSLVEALKKHVQDIEATASPEDRAELGPAVEQFGIAVKSLRRETDKLLVRCLKYSKMKKTWANVRHVLAEKDIRKTTEQVEHAKATLSVVSSLVEGCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CUF2</accession>
    <name>A0A177CUF2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glutathione-dependent formaldehyde-activating</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CC84DRAFT_1161535</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfa family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041003.1">
        <property type="nucleotide sequence ID" value="XM_018177765.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CUF2"/>
    <dbReference type="STRING" id="1460663.A0A177CUF2"/>
    <dbReference type="GeneID" id="28761251"/>
    <dbReference type="InParanoid" id="A0A177CUF2"/>
    <dbReference type="OrthoDB" id="406544at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016846">
        <property type="term" value="F:carbon-sulfur lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1590.10">
        <property type="entry name" value="glutathione-dependent formaldehyde- activating enzyme (gfa)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006913">
        <property type="entry name" value="CENP-V/GFA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337:SF33">
        <property type="entry name" value="CENP-V_GFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337">
        <property type="entry name" value="GFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04828">
        <property type="entry name" value="GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51891">
        <property type="entry name" value="CENP_V_GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CENP-V/GFA" evidence="5">
        <location>
            <begin position="9"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAG10638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="179" mass="19828" checksum="FD1B96AF2BDB85C0" modified="2016-09-07" version="1">MSLSAFIPLTGRCSCAALSYTLTASPLITHICYCTWCQRESGSICAVNSIIESSNFSYRLDPTVSQPVALIPGPTPSGNGQTVARCPVCFDGLWKYYGDARFVTYVKAGTLDEECFKRVAGGERVHIYTSTKPEWVDLGREKENGVGVFEEYYVRETVWVQEALERREKMLKAVEGVGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CUR5</accession>
    <name>A0A177CUR5_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SPT23/MGA2-like DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1161756</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041316.1">
        <property type="nucleotide sequence ID" value="XM_018177829.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CUR5"/>
    <dbReference type="STRING" id="1460663.A0A177CUR5"/>
    <dbReference type="GeneID" id="28761315"/>
    <dbReference type="InParanoid" id="A0A177CUR5"/>
    <dbReference type="OrthoDB" id="71307at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057962">
        <property type="entry name" value="SPT23_MGA2_DBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25603">
        <property type="entry name" value="SPT23_MGA2_DBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SPT23/MGA2-like DNA-binding" evidence="2">
        <location>
            <begin position="154"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="SPT23/MGA2-like DNA-binding" evidence="2">
        <location>
            <begin position="269"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="458"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="458"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG10951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="544" mass="60973" checksum="D913C8B9D1CD865D" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CV44</accession>
    <name>A0A177CV44_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ABM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1203097</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041105.1">
        <property type="nucleotide sequence ID" value="XM_018181807.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CV44"/>
    <dbReference type="GeneID" id="28765293"/>
    <dbReference type="InParanoid" id="A0A177CV44"/>
    <dbReference type="OrthoDB" id="4520428at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007138">
        <property type="entry name" value="ABM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40624">
        <property type="entry name" value="BIOSYNTHESIS MONOOXYGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12025)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40624:SF1">
        <property type="entry name" value="BIOSYNTHESIS MONOOXYGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12025)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03992">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51725">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABM" evidence="1">
        <location>
            <begin position="84"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG10740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="184" mass="20704" checksum="7C6E7C10BC72BD57" modified="2016-09-07" version="1">MPNLVVVAKLPFASSAAKETARKEEGTYTSRAAFDAHMSIDPVKDMVGWLTSNPQNIDGEATVTISENYASFTRPEVLKVADPWICYASIEYKEGKRAEALEPWKHVTSETEKNETETLSYSILKDTGHPETIKTIEVYPSQEYFKEVHVPSEAVQENAKKYGNEIRLSLAHVFLRYQAGFLGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CVB1</accession>
    <name>A0A177CVB1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CC84DRAFT_38191</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG11495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041860.1">
        <property type="nucleotide sequence ID" value="XM_018185980.1"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CVB1"/>
    <dbReference type="GeneID" id="28769466"/>
    <dbReference type="InParanoid" id="A0A177CVB1"/>
    <dbReference type="OrthoDB" id="303614at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009927">
        <property type="term" value="F:histidine phosphotransfer kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16922">
        <property type="entry name" value="HATPase_EvgS-ArcB-TorS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.130:FF:000050">
        <property type="entry name" value="Related to histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000010">
        <property type="entry name" value="Sensor histidine kinase RcsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000158">
        <property type="entry name" value="Sensor histidine kinase/response regulator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43047:SF74">
        <property type="entry name" value="HISTIDINE KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43047">
        <property type="entry name" value="TWO-COMPONENT HISTIDINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
        <property type="entry name" value="PAS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13188">
        <property type="entry name" value="PAS_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PAS" evidence="10">
        <location>
            <begin position="941"/>
            <end position="1011"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="11">
        <location>
            <begin position="1014"/>
            <end position="1066"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="10">
        <location>
            <begin position="1073"/>
            <end position="1128"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="11">
        <location>
            <begin position="1209"/>
            <end position="1263"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="8">
        <location>
            <begin position="1274"/>
            <end position="1501"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="9">
        <location>
            <begin position="1840"/>
            <end position="1962"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="228"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="324"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="496"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="633"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="756"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="817"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="903"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1135"/>
            <end position="1185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1504"/>
            <end position="1539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1551"/>
            <end position="1649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="20"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="155"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="374"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="498"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="520"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="547"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="646"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="757"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="767"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="903"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1551"/>
            <end position="1564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1565"/>
            <end position="1597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1609"/>
            <end position="1618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1639"/>
            <end position="1648"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="6">
        <location>
            <position position="1892"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OAG11495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="1978" mass="216554" checksum="13BEEAE1B8AF1FC4" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CXA2</accession>
    <name>A0A177CXA2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1253918</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG11457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041822.1">
        <property type="nucleotide sequence ID" value="XM_018184415.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CXA2"/>
    <dbReference type="GeneID" id="28767901"/>
    <dbReference type="InParanoid" id="A0A177CXA2"/>
    <dbReference type="OrthoDB" id="10480101at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG11457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="190" mass="21514" checksum="4BAC1C480DAF90E9" modified="2016-09-07" version="1">MQPLTHQQEPPPGAPSNCLSALHHAQNQTPASQRTRTTFPSLLDSTTNPSHRLLEITIFSLLRHGLTFMQIAAFLEHERTHAAQGITQLRDALRTFHFARLLNGEGARSWVEWRVATWPRWPRAWEVAMLGGWALEVWAWAVHEAGENGKTGILEDEGEGRETAGVCCHGFAILKRKRWGTLRERLRAMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CZ61</accession>
    <name>A0A177CZ61_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">mRNA export factor GLE1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Nucleoporin GLE1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CC84DRAFT_1254798</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GLE1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042931.1">
        <property type="nucleotide sequence ID" value="XM_018184489.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CZ61"/>
    <dbReference type="STRING" id="1460663.A0A177CZ61"/>
    <dbReference type="GeneID" id="28767975"/>
    <dbReference type="InParanoid" id="A0A177CZ61"/>
    <dbReference type="OrthoDB" id="420884at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044614">
        <property type="term" value="C:nuclear pore cytoplasmic filaments"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000822">
        <property type="term" value="F:inositol hexakisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.510">
        <property type="entry name" value="GLE1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012476">
        <property type="entry name" value="GLE1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038506">
        <property type="entry name" value="GLE1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12960">
        <property type="entry name" value="GLE-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12960:SF0">
        <property type="entry name" value="MRNA EXPORT FACTOR GLE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07817">
        <property type="entry name" value="GLE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="7" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0811">Translocation</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="146"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="17"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="154"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="216"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00026227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OAG12566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="573" mass="64377" checksum="61261EF4D08D23B9" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CZB1</accession>
    <name>A0A177CZB1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_71819</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042545.1">
        <property type="nucleotide sequence ID" value="XM_018187145.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CZB1"/>
    <dbReference type="GeneID" id="28770631"/>
    <dbReference type="InParanoid" id="A0A177CZB1"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG12180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="122" mass="14000" checksum="029F69C47112052C" modified="2016-09-07" version="1">MMYEGSMDDMMVASACLARCGGWSCAQDDSRFDSLRRQKRVSVDLFSPPSSAQHDDLRERWRRSISHFWFQLGVYVILGVSAWVVPVLFCEDTPLPWWLGSAFALALRSYFTAFAFSFRILA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CZG2</accession>
    <name>A0A177CZG2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Arrestin domain conatining protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_156139</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018043071.1">
        <property type="nucleotide sequence ID" value="XM_018185400.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CZG2"/>
    <dbReference type="FunCoup" id="A0A177CZG2">
        <property type="interactions" value="37"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CZG2"/>
    <dbReference type="GeneID" id="28768886"/>
    <dbReference type="InParanoid" id="A0A177CZG2"/>
    <dbReference type="OrthoDB" id="4001642at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000935">
        <property type="term" value="C:division septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000917">
        <property type="term" value="P:division septum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011022">
        <property type="entry name" value="Arrestin_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053060">
        <property type="entry name" value="Cytokinesis_Signaling_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36419">
        <property type="entry name" value="ARRESTIN FAMILY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36419:SF1">
        <property type="entry name" value="RHO1 GEF LOCALIZING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02752">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01017">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arrestin C-terminal-like" evidence="1">
        <location>
            <begin position="185"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG12706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="401" mass="44155" checksum="EC6895A1022D0321" modified="2016-09-07" version="1">MSAFVRVSGPPNSNFLVGYPGISATLPRIEGKVEIRPLVGVSAPVHVSLVTIALHRRETIHPSAESLTKKHLAAPRKEITDIVGKEMLLFRCPAGKEFDSVLSMDLPFVIFIPYGRGGEEVARRVPPASLQLPARTAETFYELVVTVQQGQTDQKKYPFPVPIQRYDTLSTFGMYNRPESAERVTDHLVTLGISLPRWSYGPLDPVSVYIKLSPNPDWLKKAQKVTIQKITVGIDEEIIFNHEGDEPTRKVKTLAKTTQAVGVKMPEAGYFTNLGLVFPAKDLRDSDGIIPRGKKEFPMYAVNGFTTTGTLYKIEYYLTVKAQLSSARDILLRQPIVVCPFDHAGCKEEMEAIEQAARDAAHVSPDNPMLPAATIIRSNDPNGLAALGMAIVGGLRKPLIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CZL4</accession>
    <name>A0A177CZL4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Amidohydrolase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CC84DRAFT_1108157</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallo-dependent hydrolases superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042474.1">
        <property type="nucleotide sequence ID" value="XM_018175192.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CZL4"/>
    <dbReference type="STRING" id="1460663.A0A177CZL4"/>
    <dbReference type="GeneID" id="28758678"/>
    <dbReference type="InParanoid" id="A0A177CZL4"/>
    <dbReference type="OrthoDB" id="432010at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032465">
        <property type="entry name" value="ACMSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240">
        <property type="entry name" value="2-AMINO-3-CARBOXYLMUCONATE-6-SEMIALDEHYDE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240:SF30">
        <property type="entry name" value="AMIDOHYDROLASE-RELATED DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008058796" evidence="4">
        <location>
            <begin position="19"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="Amidohydrolase-related" evidence="5">
        <location>
            <begin position="85"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU366045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAG12109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="332" mass="36644" checksum="567A046371DBDCA8" modified="2016-09-07" version="1">MHIAHLSTLIALALSVYGTPLSIRKPHHLPKRLIALEEHVVSPSLEAEVVAGGIVQRSPGTLEKLKDVGAGRIAAMDAGHLSMQVLAQQSASGLEDPEGCREANDAVRAAIRTNPKRFAGFAVLPIVTMLGLKGAMIWNHLKDQTYYDNARFDPVFAMAEKLDVPLYLHPAAPAADIAAKLFAGNYPAAVAGRLGTNSWGWHVDVGTHVLRLYSAGLFDRFPKLKLIIGHNGEGLPMFIDRIDSTGLRNDTTFDRVWSTNIWSTTSAFFTVRQFQQLRQVSPVERIMYSVDYPFSTNTDGWAFVEKLAEAKVLSDDEMDMFAYKNAERLLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CZM5</accession>
    <name>A0A177CZM5_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">alpha-L-rhamnosidase</fullName>
            <ecNumber evidence="2">3.2.1.40</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_1134936</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing alpha-L-rhamnose residues in alpha-L-rhamnosides.</text>
            <dbReference type="EC" id="3.2.1.40"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.2.1.40" evidence="2"/>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042717.1">
        <property type="nucleotide sequence ID" value="XM_018176040.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CZM5"/>
    <dbReference type="STRING" id="1460663.A0A177CZM5"/>
    <dbReference type="GeneID" id="28759526"/>
    <dbReference type="InParanoid" id="A0A177CZM5"/>
    <dbReference type="OrthoDB" id="10036721at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030596">
        <property type="term" value="F:alpha-L-rhamnosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.420.10">
        <property type="entry name" value="Maltose phosphorylase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016007">
        <property type="entry name" value="Alpha_rhamnosid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035396">
        <property type="entry name" value="Bac_rhamnosid6H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035398">
        <property type="entry name" value="Bac_rhamnosid_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013737">
        <property type="entry name" value="Bac_rhamnosid_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008902">
        <property type="entry name" value="Rhamnosid_concanavalin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33307">
        <property type="entry name" value="ALPHA-RHAMNOSIDASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33307:SF6">
        <property type="entry name" value="ALPHA-RHAMNOSIDASE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05592">
        <property type="entry name" value="Bac_rhamnosid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17389">
        <property type="entry name" value="Bac_rhamnosid6H"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17390">
        <property type="entry name" value="Bac_rhamnosid_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08531">
        <property type="entry name" value="Bac_rhamnosid_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25788">
        <property type="entry name" value="Ig_Rha78A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010631">
        <property type="entry name" value="A-rhamnsds"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bacterial alpha-L-rhamnosidase N-terminal" evidence="5">
        <location>
            <begin position="143"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-L-rhamnosidase concanavalin-like" evidence="4">
        <location>
            <begin position="323"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-L-rhamnosidase six-hairpin glycosidase" evidence="6">
        <location>
            <begin position="428"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-L-rhamnosidase six-hairpin glycosidase" evidence="6">
        <location>
            <begin position="513"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-L-rhamnosidase C-terminal" evidence="7">
        <location>
            <begin position="750"/>
            <end position="823"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF17389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAG12352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="837" mass="91803" checksum="621CB82CB310B3E0" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177D020</accession>
    <name>A0A177D020_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">PNPLA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CC84DRAFT_1212515</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Probable lipid hydrolase.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG13055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018043420.1">
        <property type="nucleotide sequence ID" value="XM_018182459.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177D020"/>
    <dbReference type="STRING" id="1460663.A0A177D020"/>
    <dbReference type="GeneID" id="28765945"/>
    <dbReference type="InParanoid" id="A0A177D020"/>
    <dbReference type="OrthoDB" id="10049244at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006641">
        <property type="term" value="P:triglyceride metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07229">
        <property type="entry name" value="Pat_TGL3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050301">
        <property type="entry name" value="NTE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021771">
        <property type="entry name" value="Triacylglycerol_lipase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14226">
        <property type="entry name" value="NEUROPATHY TARGET ESTERASE/SWISS CHEESE D.MELANOGASTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14226:SF44">
        <property type="entry name" value="TRIACYLGLYCEROL LIPASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11815">
        <property type="entry name" value="DUF3336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008058833" description="PNPLA domain-containing protein" evidence="7">
        <location>
            <begin position="22"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="domain" description="PNPLA" evidence="8">
        <location>
            <begin position="173"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="527"/>
            <end position="580"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAG13055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="580" mass="65179" checksum="8D13E741AAE908B3" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177D0F2</accession>
    <name>A0A177D0F2_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="5">PPIase</shortName>
            <ecNumber evidence="5">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CC84DRAFT_156147</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cyclophilin-type PPIase family. PPIL3 subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="5"/>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018043072.1">
        <property type="nucleotide sequence ID" value="XM_018185401.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177D0F2"/>
    <dbReference type="STRING" id="1460663.A0A177D0F2"/>
    <dbReference type="GeneID" id="28768887"/>
    <dbReference type="InParanoid" id="A0A177D0F2"/>
    <dbReference type="OrthoDB" id="271386at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01928">
        <property type="entry name" value="Cyclophilin_PPIL3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024936">
        <property type="entry name" value="Cyclophilin-type_PPIase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044666">
        <property type="entry name" value="Cyclophilin_A-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625:SF2">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001467">
        <property type="entry name" value="Peptidylpro_ismrse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="6">
        <location>
            <begin position="10"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAG12707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="165" mass="18092" checksum="D5682BD74A628681" modified="2016-09-07" version="1">MSVTLHTTRGDIKLEIFCEAVPKTAENFLALCASGFYNGSPFHRMIPSFMVQTGSPASDPKSKTSTSIYDTVDHLFEDEVRPALRHNARGIVSMANKGPNSNGSQFFITFAPAPHLDGKNTVFGKVLEGEDVLDELETLDVDKKSRPKERVEIKNVTMHANPLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177D0G7</accession>
    <name>A0A177D0G7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Tat pathway signal sequence</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CC84DRAFT_1228221</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Mycotoxin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ustYa family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG13184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018043549.1">
        <property type="nucleotide sequence ID" value="XM_018183629.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177D0G7"/>
    <dbReference type="STRING" id="1460663.A0A177D0G7"/>
    <dbReference type="GeneID" id="28767115"/>
    <dbReference type="InParanoid" id="A0A177D0G7"/>
    <dbReference type="OrthoDB" id="3687641at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021765">
        <property type="entry name" value="UstYa-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365:SF4">
        <property type="entry name" value="CYCLOCHLOROTINE BIOSYNTHESIS PROTEIN O"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365">
        <property type="entry name" value="YALI0B05434P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11807">
        <property type="entry name" value="UstYa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="46"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="12"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00035112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAG13184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="264" mass="30446" checksum="AFEBDBAAF3E142CC" modified="2016-09-07" version="1">MKFLLAQGYQRVEQEQSSEKSSRTSLEGFDTSGSPIASRRMIWYRWLPWVLVAILTITNCYAWMATRSTHFPESIFSPATSAIKYKTVIFQAGIDSDTSPYQGKPSQEIDHEWEELHKYGVSRIPMSDAAQLANRTSPIPGDEGHYVVILEVFHQLHCLQHVRRRLFWNETEQGSPDEVEALSMKHLDHCIDSIRQSLMCSADVTPLPYVWWRKYDQLMPATAVAHTCRDFEAIRDWAKEHRAGKVDKHTQVYDPLGDQVVYDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BSZ9</accession>
    <name>A0A177BSZ9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH CENPB-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_520111</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441570">
        <property type="protein sequence ID" value="OAF98503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018028869.1">
        <property type="nucleotide sequence ID" value="XM_018186600.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BSZ9"/>
    <dbReference type="STRING" id="1460663.A0A177BSZ9"/>
    <dbReference type="GeneID" id="28770086"/>
    <dbReference type="InParanoid" id="A0A177BSZ9"/>
    <dbReference type="OrthoDB" id="3794134at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03221">
        <property type="entry name" value="HTH_Tnp_Tc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH CENPB-type" evidence="2">
        <location>
            <begin position="16"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAF98503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="182" mass="20885" checksum="36ECEC2E69880AFF" modified="2016-09-07" version="1">MSRHDCPGTNLRLSQVQDEDLKSYIRRCDDIGMPCLMLQLIGAAQYIIDRAHPNGRAPPLSKDWLSRWLERNPDCRRMKQKSQNINWTAMATFEVYSHYFTELKKVIYTHGITTYDTYNMDETGFRIGVGGSQWIVTMEMNRPQVSASETSRDYITSIEAISGDGQVLNPMLVVQGVNHLHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BTB0</accession>
    <name>A0A177BTB0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RTA1 like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CC84DRAFT_1238489</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441567">
        <property type="protein sequence ID" value="OAF98544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018028910.1">
        <property type="nucleotide sequence ID" value="XM_018183942.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BTB0"/>
    <dbReference type="STRING" id="1460663.A0A177BTB0"/>
    <dbReference type="GeneID" id="28767428"/>
    <dbReference type="InParanoid" id="A0A177BTB0"/>
    <dbReference type="OrthoDB" id="3358017at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007568">
        <property type="entry name" value="RTA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465:SF1">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04479">
        <property type="entry name" value="RTA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="47"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="121"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="159"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="204"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="241"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAF98544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="288" mass="32300" checksum="B4D729D91A83F8A1" modified="2016-09-07" version="1">MPELLPINGGTYYLWKYVPSVPASAIFAIAWLVIAALLSWRMHTTRTWFCSAFIIGCFMEFVGYCARAAAGNHTNAIVPYVVQSTMILLPPALFAATIYMCLGRIILVVEASHLSIISPRWLTGLFVTGDVLSFIFLGNSAPLTILSTDHPFLAIIGKWAVIGGLAIQLISFSCFGITAVIFHSRIRKRPTEASFQVDQAWIKTLHMLYAVSLLIIVRSIFRIIEYVSGENSYLLTHEWPLYVFDTVTMFAVAIVFFFLYPSDIVIRKMSHTPLQDFERDEGLVPKCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2024-01-24" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BU25</accession>
    <name>A0A177BU25_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FHA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1223750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441569">
        <property type="protein sequence ID" value="OAF98510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018028876.1">
        <property type="nucleotide sequence ID" value="XM_018183520.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BU25"/>
    <dbReference type="GeneID" id="28767006"/>
    <dbReference type="InParanoid" id="A0A177BU25"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="1">
        <location>
            <begin position="63"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAF98510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="138" mass="15148" checksum="86358BBCBE3035D7" modified="2016-09-07" version="1">MSPPGYCRSFRQLPRLVLERAKDHHLEPFPKRVILLEDGDVLTIGSASGRRPALANNARFSGSLDKDHAVIRSVRPGALQICNTSTTHGVVVDGLRLSFGQKWRLEQGSVITLEDESDLLYQLKPVKISVFCIPGTGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BWA6</accession>
    <name>A0A177BWA6_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_366074</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441561">
        <property type="protein sequence ID" value="OAF99584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029950.1">
        <property type="nucleotide sequence ID" value="XM_018185938.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BWA6"/>
    <dbReference type="STRING" id="1460663.A0A177BWA6"/>
    <dbReference type="GeneID" id="28769424"/>
    <dbReference type="InParanoid" id="A0A177BWA6"/>
    <dbReference type="OrthoDB" id="1022638at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAF99584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="267" mass="30559" checksum="398EC33DB1A456AC" modified="2016-09-07" version="1">MSYAATRRRMFTGAHWDEESGRTRAMADLTFTFGSSYGSGSGYRDIRDFRSHLNFDRAIHGSEAPQESAVISLSDHDPDAFALWRTWIYTGKLAILPDPPLPSDSNDERTAHYAVLAHAYILGDYLVDIPFMNAIADVYVLNARGIDGARALYPSNEEIGVLYDGTSPDSPIRRLLVDIWMYRGKPEWLEREVDEDVLPREFLVEVVRKLLELKKVREGETMSRPWKMTHEQYHDRREVGVQEEMAEAHRCEDEDAPAVGFDDLFPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BX96</accession>
    <name>A0A177BX96_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">GABA permease-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CC84DRAFT_1191249</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441562">
        <property type="protein sequence ID" value="OAF99308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029674.1">
        <property type="nucleotide sequence ID" value="XM_018181174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BX96"/>
    <dbReference type="STRING" id="1460663.A0A177BX96"/>
    <dbReference type="GeneID" id="28764660"/>
    <dbReference type="InParanoid" id="A0A177BX96"/>
    <dbReference type="OrthoDB" id="3257095at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF4">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="50"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="165"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="207"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="247"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="298"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="349"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="373"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="420"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="450"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAF99308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="489" mass="53765" checksum="D80478C60118E454" modified="2016-09-07" version="1">MVRMGKVQELRRNYHSLSALAFTVIIQGAWEVLLTATTQGLVDGGPAGLIWSYVWTFIGFSFVVASLAEMASMAPTAGGQYHWVSEFSPPSVQKPFSFFIGWMSTLSWQAGTASGPYLVGTLIQSCAIVVYPDYAPTGWQGTLMVIAITLLVWVLNVYGANLMPLFQNLMLVFHIVGFLVIIVILWVRSPRATAKATFTEFTNDGGWNSIGLALMVGQISAIYACISTDAAAHMSEETQDAGRTVPRAMLGAYFLNGILGFVFLISYMFMMTDVEAALEDATGYPHIWVFSQAVPKGAVVVLNAIPTILIFAGTLSFNLSTSRQTWAFARDEGFPLSGWLGKVHPKLHVPVNAITFTSIFTVLLSLINVGSNAAFNAIISLNVVSLMITYMFSIGAVLYRRIYHPELLPRCRWSLGRFGVLVNSVGLLYATHAFFWCFWPNATPFALEDFNWSVVMFVAVAVLCLVDYAIRGRKVYKGPVVLVEGWHNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BXI1</accession>
    <name>A0A177BXI1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Ferrochelatase</fullName>
            <ecNumber evidence="12">4.98.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CC84DRAFT_1157409</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the ferrous insertion into protoporphyrin IX.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>heme b + 2 H(+) = protoporphyrin IX + Fe(2+)</text>
            <dbReference type="Rhea" id="RHEA:22584"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:57306"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="EC" id="4.98.1.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Porphyrin-containing compound metabolism; protoheme biosynthesis; protoheme from protoporphyrin-IX: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the ferrochelatase family.</text>
    </comment>
    <dbReference type="EC" id="4.98.1.1" evidence="12"/>
    <dbReference type="EMBL" id="KV441562">
        <property type="protein sequence ID" value="OAF99411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029777.1">
        <property type="nucleotide sequence ID" value="XM_018177011.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BXI1"/>
    <dbReference type="FunCoup" id="A0A177BXI1">
        <property type="interactions" value="714"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177BXI1"/>
    <dbReference type="GeneID" id="28760497"/>
    <dbReference type="InParanoid" id="A0A177BXI1"/>
    <dbReference type="OrthoDB" id="1323at2759"/>
    <dbReference type="UniPathway" id="UPA00252">
        <property type="reaction ID" value="UER00325"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004325">
        <property type="term" value="F:ferrochelatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006783">
        <property type="term" value="P:heme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00419">
        <property type="entry name" value="Ferrochelatase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03411">
        <property type="entry name" value="Ferrochelatase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1400:FF:000003">
        <property type="entry name" value="Ferrochelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1400">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00323">
        <property type="entry name" value="Ferrochelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001015">
        <property type="entry name" value="Ferrochelatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019772">
        <property type="entry name" value="Ferrochelatase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033644">
        <property type="entry name" value="Ferrochelatase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033659">
        <property type="entry name" value="Ferrochelatase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00109">
        <property type="entry name" value="hemH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11108">
        <property type="entry name" value="FERROCHELATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11108:SF1">
        <property type="entry name" value="FERROCHELATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00762">
        <property type="entry name" value="Ferrochelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53800">
        <property type="entry name" value="Chelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00534">
        <property type="entry name" value="FERROCHELATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="6 12" id="KW-0408">Iron</keyword>
    <keyword evidence="10 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 12" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11 12" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OAF99411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="428" mass="47245" checksum="4F255B71CB681C8A" modified="2016-09-07" version="1">MAMRSPLSHAVKRTTYKSPATPVLSPCTQRWKRSNATVAPPPVTQSSAGSKGPTAMVFMNMGGPSTTDEVHGFLSNLFSDADLIPLGRLQNYIGPYIARRRTPKIQKQYAEIGGGSPIRKWSEYQAAEMCKILDQTSPETAPHKPYVAFRYANPLTEEMYNRLLADGFGGGKGGRAVAFTQYPQYSCSTTGSSLNELWKWRQRLEGKRAGGEVNPEGAIKWSVIDRWPTHPGLVEAFAQNIEKTLQEYPPERRDNVVLLYSAHSLPMTVVNRGDPYPQEVAATVHAVNQRLGMKYKYRLVWQSQVGPQPWLGAQTSDTVKNLMKKGNTDLILIPIAFTSDHIETLYELDKEVIGEDAEGHEGVKRVESLNGNPIFIQGLADIAKAHLHAGVACSNQMTLRCPGCVSERCLGSKEFFAGQNKLLEPLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BXS5</accession>
    <name>A0A177BXS5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">DUF21-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CC84DRAFT_1130098</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441560">
        <property type="protein sequence ID" value="OAG00153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030518.1">
        <property type="nucleotide sequence ID" value="XM_018175849.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BXS5"/>
    <dbReference type="FunCoup" id="A0A177BXS5">
        <property type="interactions" value="63"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177BXS5"/>
    <dbReference type="GeneID" id="28759335"/>
    <dbReference type="InParanoid" id="A0A177BXS5"/>
    <dbReference type="OrthoDB" id="5353557at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010961">
        <property type="term" value="P:intracellular magnesium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030026">
        <property type="term" value="P:intracellular manganese ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd04590">
        <property type="entry name" value="CBS_pair_CorC_HlyC_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.580.10:FF:000006">
        <property type="entry name" value="DUF21 and CBS domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045095">
        <property type="entry name" value="ACDP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002550">
        <property type="entry name" value="CNNM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044751">
        <property type="entry name" value="Ion_transp-like_CBS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12064">
        <property type="entry name" value="METAL TRANSPORTER CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12064:SF97">
        <property type="entry name" value="METAL TRANSPORTER CNNM-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01595">
        <property type="entry name" value="CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51846">
        <property type="entry name" value="CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0129">CBS domain</keyword>
    <keyword evidence="5 7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 7 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="62"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="123"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="CNNM transmembrane" evidence="11">
        <location>
            <begin position="60"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="10">
        <location>
            <begin position="331"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="439"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="464"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="543"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="587"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="603"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="632"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="680"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="705"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="721"/>
            <end position="734"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OAG00153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="750" mass="80624" checksum="3A05A46BF4B94094" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BXU6</accession>
    <name>A0A177BXU6_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Transcription-associated protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_1264449</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Required for the control of telomere length and genome stability.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Associates with DNA double-strand breaks.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PI3/PI4-kinase family. TRA1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV441562">
        <property type="protein sequence ID" value="OAF99521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029887.1">
        <property type="nucleotide sequence ID" value="XM_018185310.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A177BXU6">
        <property type="interactions" value="1102"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177BXU6"/>
    <dbReference type="GeneID" id="28768796"/>
    <dbReference type="InParanoid" id="A0A177BXU6"/>
    <dbReference type="OrthoDB" id="5570127at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05163">
        <property type="entry name" value="PIKK_TRRAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050517">
        <property type="entry name" value="DDR_Repair_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003152">
        <property type="entry name" value="FATC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003151">
        <property type="entry name" value="PIK-rel_kinase_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014009">
        <property type="entry name" value="PIK_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046807">
        <property type="entry name" value="Tra1_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046805">
        <property type="entry name" value="Tra1_ring"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139">
        <property type="entry name" value="ATAXIA TELANGIECTASIA MUTATED ATM -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139:SF1">
        <property type="entry name" value="TRANSFORMATION_TRANSCRIPTION DOMAIN-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02259">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20175">
        <property type="entry name" value="Tra1_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20206">
        <property type="entry name" value="Tra1_ring"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51189">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51190">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAT" evidence="6">
        <location>
            <begin position="2638"/>
            <end position="3193"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="5">
        <location>
            <begin position="3464"/>
            <end position="3786"/>
        </location>
    </feature>
    <feature type="domain" description="FATC" evidence="7">
        <location>
            <begin position="3782"/>
            <end position="3814"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="160"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="2012"/>
            <end position="2036"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="2285"/>
            <end position="2314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="3199"/>
            <end position="3292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="160"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="3199"/>
            <end position="3208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="3217"/>
            <end position="3249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAF99521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="3814" mass="434048" checksum="A89BF515E2149202" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BYI9</accession>
    <name>A0A177BYI9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Large ribosomal subunit protein bL33m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CC84DRAFT_1169048</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial ribosomal protein bL33 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441560">
        <property type="protein sequence ID" value="OAG00216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030581.1">
        <property type="nucleotide sequence ID" value="XM_018179556.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BYI9"/>
    <dbReference type="FunCoup" id="A0A177BYI9">
        <property type="interactions" value="219"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177BYI9"/>
    <dbReference type="GeneID" id="28763042"/>
    <dbReference type="InParanoid" id="A0A177BYI9"/>
    <dbReference type="OrthoDB" id="275534at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.120">
        <property type="entry name" value="Ribosomal protein L33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052008">
        <property type="entry name" value="Mitoribosomal_protein_bL33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001705">
        <property type="entry name" value="Ribosomal_bL33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038584">
        <property type="entry name" value="Ribosomal_bL33_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01023">
        <property type="entry name" value="rpmG_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47037">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L33, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47037:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL33M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00471">
        <property type="entry name" value="Ribosomal_L33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 7" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAG00216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="58" mass="6971" checksum="51463F3A19F218E3" modified="2016-09-07" version="1">MAKKAKSRTIMVRLISMAMTGYYRTLMRPRVHRPLSMMKYDPIVRKQVLFLEQKRGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BYX4</accession>
    <name>A0A177BYX4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fungal N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1155318</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441559">
        <property type="protein sequence ID" value="OAG00475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030840.1">
        <property type="nucleotide sequence ID" value="XM_018176928.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BYX4"/>
    <dbReference type="STRING" id="1460663.A0A177BYX4"/>
    <dbReference type="GeneID" id="28760414"/>
    <dbReference type="InParanoid" id="A0A177BYX4"/>
    <dbReference type="OrthoDB" id="5431013at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005884">
        <property type="term" value="C:actin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030041">
        <property type="term" value="P:actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051412">
        <property type="entry name" value="Formin_Homology_Diaphanous_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45691">
        <property type="entry name" value="PROTEIN DIAPHANOUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45691:SF6">
        <property type="entry name" value="PROTEIN DIAPHANOUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="280"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="480"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="329"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="488"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="517"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="567"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="612"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="650"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="664"/>
            <end position="690"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG00475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="711" mass="79137" checksum="57988EC058EA1D2B" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BYX6</accession>
    <name>A0A177BYX6_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_364537</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441561">
        <property type="protein sequence ID" value="OAF99539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029905.1">
        <property type="nucleotide sequence ID" value="XM_018185931.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BYX6"/>
    <dbReference type="STRING" id="1460663.A0A177BYX6"/>
    <dbReference type="GeneID" id="28769417"/>
    <dbReference type="InParanoid" id="A0A177BYX6"/>
    <dbReference type="OrthoDB" id="3199516at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="841"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="73"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="850"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="872"/>
            <end position="895"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAF99539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="929" mass="103291" checksum="74E5F4FFB8F19B3C" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BZ87</accession>
    <name>A0A177BZ87_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">rRNA-processing protein-like protein FCF1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_1168573</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the UTP23/FCF1 family. FCF1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV441559">
        <property type="protein sequence ID" value="OAG00476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030841.1">
        <property type="nucleotide sequence ID" value="XM_018179434.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BZ87"/>
    <dbReference type="FunCoup" id="A0A177BZ87">
        <property type="interactions" value="908"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177BZ87"/>
    <dbReference type="GeneID" id="28762920"/>
    <dbReference type="InParanoid" id="A0A177BZ87"/>
    <dbReference type="OrthoDB" id="76105at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000480">
        <property type="term" value="P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000472">
        <property type="term" value="P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd09864">
        <property type="entry name" value="PIN_Fcf1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000019">
        <property type="entry name" value="U3 small nucleolar RNA-associated protein 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006984">
        <property type="entry name" value="Fcf1/UTP23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037503">
        <property type="entry name" value="Fcf1_PIN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12416">
        <property type="entry name" value="RRNA-PROCESSING PROTEIN UTP23 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04900">
        <property type="entry name" value="Fcf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00670">
        <property type="entry name" value="PINc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="PIN" evidence="7">
        <location>
            <begin position="67"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="33"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAG00476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="196" mass="22413" checksum="19F3C0A345EF5B50" modified="2016-09-07" version="1">MGVAKKTRKFAQMKRVIGQRDARLKKNQMSGELEAKKKADTEKAKREIPQAPSSMFFMANEALGPPYRVLIDTNFLSHTVRGKLELQKSLMDLLYAKATPIISSCVMAELEKLGPKYRIALRIARDERWERIKCDHKGTYADDCIVDMVTKHRIYLVGTNDRDLKRRIRKIPGVPIVSVAKGKYVIERLPDNPDSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BZE3</accession>
    <name>A0A177BZE3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1168819</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441560">
        <property type="protein sequence ID" value="OAF99907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030273.1">
        <property type="nucleotide sequence ID" value="XM_018179492.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BZE3"/>
    <dbReference type="GeneID" id="28762978"/>
    <dbReference type="InParanoid" id="A0A177BZE3"/>
    <dbReference type="OrthoDB" id="3777003at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAF99907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="248" mass="27943" checksum="1DE9A096308DD795" modified="2016-09-07" version="1">MVILGGLEIVAGGYFFHRYQKNKNEKKRLEQEAQQRRHNTFPGAKPQPCYPSHPQHDIPPQKYGYVSHAPPHRPQPPYPPPHRPHTEPPPHRPHNGRHASQPQSFMIPRRPLPKQQYAPPPQIIQPLQRADSMATISRMPIANGYRPSHVADDPQLPSRRQNSQLSPIPQSPMSSPYGNHGFAVSSPALINNRTTQTYSPVRPGGRQTVDDNWETYSHQAPASGHYAPSFSTALGEVRDDDPPPPYRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BZL7</accession>
    <name>A0A177BZL7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_1169007</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441560">
        <property type="protein sequence ID" value="OAG00159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030524.1">
        <property type="nucleotide sequence ID" value="XM_018179552.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BZL7"/>
    <dbReference type="STRING" id="1460663.A0A177BZL7"/>
    <dbReference type="GeneID" id="28763038"/>
    <dbReference type="InParanoid" id="A0A177BZL7"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF236">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAG00159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="324" mass="35583" checksum="BC57837884D335D4" modified="2016-09-07" version="1">MPSLDFVKAVWTQHFPPAPTFTEKNIAPQKGKTFLITGANQGLGYELAKLLYPTGATVYMASRSEERTSQAIHKIQEAHPEAATPGTLKFLHVDMADLASVKRAAIEFAAQEAKLDVLWNNAGIGGAPLGTTTAQNIEGHIGTNCVAPLLFTQLLLPLLREAATSAPKGSVRVVWTSSLMVDTFSPTNGIDFKTIEAGKTTDSNIDYAVSKVGNWFLSHEAAKAWEPYGISSVVQNPGNLNTEAYRYVPGIMRKFLQTFLLYETKYGAYTMAYAGLSEEVMNGEYVWPWGRKGKSPRADIHEAIEKGAAERFWAWCEEIAKPYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BZN2</accession>
    <name>A0A177BZN2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1209568</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441559">
        <property type="protein sequence ID" value="OAG00675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031040.1">
        <property type="nucleotide sequence ID" value="XM_018182227.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BZN2"/>
    <dbReference type="GeneID" id="28765713"/>
    <dbReference type="InParanoid" id="A0A177BZN2"/>
    <dbReference type="OrthoDB" id="10543261at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG00675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="226" mass="25613" checksum="480CF07893FAF1F8" modified="2016-09-07" version="1">MGFVSKIKSAFGSKSHREPKQSEVVGPAEEIMFPAQLTRVGPAQTALPDRHWTQSREVDCSDYRGNVHMAQAPYQQESSITESSGHSSGFEGVYIAALREMNTCVNDFSQKYSDASDMAVSFGLFAPRELGYRPGHVEELDSFELKRSNALRRKTTASRHRRVLSHGCYMPLRFFLDRRDCGSRGWSFAGCRWTCRGHTHESPQCPQRKRKMRGVALARLEGRHKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C070</accession>
    <name>A0A177C070_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF1446-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_1179978</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441558">
        <property type="protein sequence ID" value="OAG00865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031230.1">
        <property type="nucleotide sequence ID" value="XM_018180452.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C070"/>
    <dbReference type="GeneID" id="28763938"/>
    <dbReference type="InParanoid" id="A0A177C070"/>
    <dbReference type="OrthoDB" id="10265871at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056362">
        <property type="entry name" value="AtuA-like_ferredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010839">
        <property type="entry name" value="AtuA_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47585">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47585:SF2">
        <property type="entry name" value="DUF1446 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G11420)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07287">
        <property type="entry name" value="AtuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23544">
        <property type="entry name" value="AtuA_ferredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyclic terpene utilisation N-terminal" evidence="2">
        <location>
            <begin position="9"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="domain" description="AtuA-like ferredoxin-fold" evidence="3">
        <location>
            <begin position="536"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAG00865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="637" mass="70510" checksum="CB5D9079D780BA29" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2023-06-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C0E8</accession>
    <name>A0A177C0E8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_269198</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441558">
        <property type="protein sequence ID" value="OAG00886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031251.1">
        <property type="nucleotide sequence ID" value="XM_018185681.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C0E8"/>
    <dbReference type="GeneID" id="28769167"/>
    <dbReference type="InParanoid" id="A0A177C0E8"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG00886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="149" mass="16827" checksum="CE759A17ECA5B2CE" modified="2016-09-07" version="1">MLNQPTPGIRSRRAANEHASSENFLIMMKTPPEIYRKETIRKDITVARSKKNKEPLITLLDAHPIVIPALLPVRKDAVLEKYTNGKRSCKCHIQVNSTLLILRGHQKQPQETPSRCKEAMSLLIFVNADTPGEIRGNETSSRSMSERTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C0F7</accession>
    <name>A0A177C0F7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1168269</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441558">
        <property type="protein sequence ID" value="OAG01123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031488.1">
        <property type="nucleotide sequence ID" value="XM_018179356.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C0F7"/>
    <dbReference type="STRING" id="1460663.A0A177C0F7"/>
    <dbReference type="GeneID" id="28762842"/>
    <dbReference type="InParanoid" id="A0A177C0F7"/>
    <dbReference type="OrthoDB" id="5404940at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="82"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="309"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="381"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="483"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="546"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="635"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="309"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="381"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="396"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="552"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="648"/>
            <end position="661"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG01123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="684" mass="75627" checksum="79742AF46B150CC0" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C1E6</accession>
    <name>A0A177C1E6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HAD-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1179655</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441557">
        <property type="protein sequence ID" value="OAG01604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031969.1">
        <property type="nucleotide sequence ID" value="XM_018180427.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C1E6"/>
    <dbReference type="STRING" id="1460663.A0A177C1E6"/>
    <dbReference type="GeneID" id="28763913"/>
    <dbReference type="InParanoid" id="A0A177C1E6"/>
    <dbReference type="OrthoDB" id="2363873at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="entry name" value="Putative phosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051540">
        <property type="entry name" value="S-2-haloacid_dehalogenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43316:SF4">
        <property type="entry name" value="ACID DEHALOGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G05870)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43316">
        <property type="entry name" value="HYDROLASE, HALOACID DELAHOGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG01604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="241" mass="26762" checksum="BA4CC85A40C59359" modified="2016-09-07" version="1">MKQSASFDVIGTCFDFTAPIEAIHSRLGPKLATAKTDPKTLFFSWFYAAQRDFTYVSLAGAYKPIAEILRLTFKRACRIVDLPADAVSDEDVAAIMKAFKGMGPREGLKKCFDGLREAGWDVYAVTNGGVETSLAYYHNAGIDLDENHLLSCDALQVAKPDVKVYENAQNHLSKQGLGTKDDRRRWFVAAHAWDLIAARQAGFKTAYLDFEEHDPVTEVFGEFDLYAASMDELLAKLQSVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C1F1</accession>
    <name>A0A177C1F1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1208608</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441557">
        <property type="protein sequence ID" value="OAG01473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031838.1">
        <property type="nucleotide sequence ID" value="XM_018182170.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C1F1"/>
    <dbReference type="GeneID" id="28765656"/>
    <dbReference type="InParanoid" id="A0A177C1F1"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="316"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="316"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG01473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="456" mass="49319" checksum="8B6FE91897014482" modified="2016-09-07" version="1" fragment="single">MAYSDRDVTWTPPVSKDGSMCEGECNQGVLRIFQKTDTGDDPGRRAREGSIHGGCDGHMEVRWRDERVLGEPPPPDHTAGTGAGPRNGMSCQWPQATPPDDAAMVEEPFDDLARQETNHSAASPRCILFFACMKRLCDAARPMLARPTDQLLLAVLSLQSVTAQLVAPRAGRGRPPLLSSARPALGRNACQPSADPRGRSVTMAAGLHPSASPTISWSDIGDLAQVRSCSPSCHPQFAEGAQLLLSLTPPAQRHTHISGTRYPKRGLALLPHPYPHPSSPARPYYYTVWPPPWRVGPFLLRPSRLMLSHPNVAVPTLTSSQPTQPTPHASVSTPACTRPHLHPKTIVASDAVCGQPYLILLRSWGSITPSPTLPGSSTFLLRATVLSRFGYEPRRSTITFVILKRCHIGTPPAGSAQKHPRRNGPRISLRACQASEALRRLLFPLSGSIGCASDAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C1J4</accession>
    <name>A0A177C1J4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">sphingolipid C(9)-methyltransferase</fullName>
            <ecNumber evidence="14">2.1.1.317</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CC84DRAFT_1102271</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CFA/CMAS family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.317" evidence="14"/>
    <dbReference type="EMBL" id="KV441559">
        <property type="protein sequence ID" value="OAG00668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031033.1">
        <property type="nucleotide sequence ID" value="XM_018174956.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C1J4"/>
    <dbReference type="STRING" id="1460663.A0A177C1J4"/>
    <dbReference type="GeneID" id="28758442"/>
    <dbReference type="InParanoid" id="A0A177C1J4"/>
    <dbReference type="OrthoDB" id="412182at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006665">
        <property type="term" value="P:sphingolipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052290">
        <property type="entry name" value="Sphingo_C9-MT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45197:SF1">
        <property type="entry name" value="SPHINGOLIPID C9-METHYLTRANSFERASE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45197">
        <property type="entry name" value="SYNTHASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G04190)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02353">
        <property type="entry name" value="CMAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 16" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="10" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="7 16" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00039020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OAG00668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="506" mass="57495" checksum="BF3AA7E3A967638F" modified="2016-09-07" version="1">MSSGTTSEETFEWIETPPARTPTKPAFDCGVRTTSYPAIPNAPLPADSNGRDHFSNTALISALVGVPGYITWKLGGGLKTWIFFALIVDLPILAAFWIVTSEYAPRKNEKAKFPGKPIETYLEFHKSEDREAYHGKKIPMETFYEKYFDGDVDFKGDCLEVMELRHDWANFRFTFGLIKHFLFGMIPEMIMHTRSQDEEQVRDHYDRGDDFYGWFLGPRMIYTSGIISDINREETLEELQDNKMAIVCEKIGLQKGEKMLDIGCGWGTLTRFASVHYGAHVTGVTLGRNQTKWGNNGLRKNGIGEDQSNILCMDYRDIPVPSGGYKKITCLEMAEHVGVRHFAGFATQVREMLDDDGVFFLQIAGLRKEWQFEDFTWGLFMNKYVFPGADASTPLGWVVDKLEGAGFEVKQIDTVGVHYSATLWKWYRNWIGNKEKVTAKYGKRWFRIWEFFLAYSTIASRQGTATCFQITLVKNINSTHRVEGINTQFALSAALEASKAKGIKGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C1V6</accession>
    <name>A0A177C1V6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HET-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1049689</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441557">
        <property type="protein sequence ID" value="OAG01643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032008.1">
        <property type="nucleotide sequence ID" value="XM_018173457.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C1V6"/>
    <dbReference type="GeneID" id="28756943"/>
    <dbReference type="InParanoid" id="A0A177C1V6"/>
    <dbReference type="OrthoDB" id="2157530at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF64">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="43"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG01643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="176" mass="20292" checksum="0CC9633E14FB3311" modified="2016-09-07" version="1" fragment="single">YFPLDISRREIRLLVVQPAVAELRDSPLEEQLSGSGQGDSLKYMALSYTWGDPEPTFSILLEGMDFRIRENLYEALLHFRPTRGKLVIWIDAVCINQEDEQERESQVAMMRDIYKEAEGVWAWLGPGDASRSRAAFAFLSDLAHREYSDVRGGYPNVLESPWFSRMWIIQEVVMGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C293</accession>
    <name>A0A177C293_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">inorganic diphosphatase</fullName>
            <ecNumber evidence="3">3.6.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_1100926</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.1" evidence="3"/>
    <dbReference type="EMBL" id="KV441558">
        <property type="protein sequence ID" value="OAG00847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031212.1">
        <property type="nucleotide sequence ID" value="XM_018174889.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C293"/>
    <dbReference type="STRING" id="1460663.A0A177C293"/>
    <dbReference type="GeneID" id="28758375"/>
    <dbReference type="InParanoid" id="A0A177C293"/>
    <dbReference type="OrthoDB" id="1608002at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004427">
        <property type="term" value="F:inorganic diphosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006796">
        <property type="term" value="P:phosphate-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.80.10">
        <property type="entry name" value="Inorganic pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008162">
        <property type="entry name" value="Pyrophosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036649">
        <property type="entry name" value="Pyrophosphatase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10286">
        <property type="entry name" value="INORGANIC PYROPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00719">
        <property type="entry name" value="Pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50324">
        <property type="entry name" value="Inorganic pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008057604" description="inorganic diphosphatase" evidence="7">
        <location>
            <begin position="19"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAG00847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="342" mass="39084" checksum="6DA5834F1D0ECB38" modified="2016-09-07" version="1">MFSTTFLTSLAFLSVVSTSPLDTRTSSKKGPKPDEKCAEFDYENLSLREVGQRNTLDWRMYLLHRDEPISFWHDVPLYPDASNKQIINFVVEIPRWTDGKIETSRPEALNPIFHDDKNGAPRYVESVWPHKGYPFLYGSIPQTWENPNVNHSFTGFPGDKDPMDLFDIGQDDGYTGQIKQVKLLGGLAVNDGDETDWKMLGIDVKDPLATVVNTHEDVEKYRPGTIQAFRDWFTYYKVARGDDVIPVVGETYQNISFVMDTVEESHKYWEDLVSGKEDPGKISTVQTSQIDLSSWVPCKDARKELGIPKKSSKPQEPAAKPEKYSWWYYLNAERQLIEVPGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C2E2</accession>
    <name>A0A177C2E2_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Thioredoxin-like fold domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1167563</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAX family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441557">
        <property type="protein sequence ID" value="OAG01321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031686.1">
        <property type="nucleotide sequence ID" value="XM_018179202.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C2E2"/>
    <dbReference type="STRING" id="1460663.A0A177C2E2"/>
    <dbReference type="GeneID" id="28762688"/>
    <dbReference type="InParanoid" id="A0A177C2E2"/>
    <dbReference type="OrthoDB" id="5809458at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026928">
        <property type="entry name" value="FAX/IsoI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050931">
        <property type="entry name" value="Mito_Protein_Transport_Metaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012336">
        <property type="entry name" value="Thioredoxin-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12289:SF41">
        <property type="entry name" value="FAILED AXON CONNECTIONS-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12289">
        <property type="entry name" value="METAXIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17172">
        <property type="entry name" value="GST_N_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01180">
        <property type="entry name" value="SUF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01200">
        <property type="entry name" value="SUF1.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin-like fold" evidence="2">
        <location>
            <begin position="25"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG01321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="259" mass="29237" checksum="F309574C5A0A7384" modified="2016-09-07" version="1">MASKSSPAITLYRGWNTPSQYVWSPFVTKVEFRLRTSHVPYTCGVGGPRAGPRGKIPYLEITPLDAPTELLSDSTLILRTFTERGVVNDVNTGLTGVQQGQDLAVRALLEDRLYFLQGRERWVNNYYTMRDHALWSIPYPMRLVIGLLAYRANVRKLYEQGAGRFSDTETRALIRDVWGGVSGLLGESRRAAPRDACFWVLGGKEPTEADATLFGFVVSNLVCDAAPETRELLKGEFPVVVEYAERIHGRWFPDYEIWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C2F0</accession>
    <name>A0A177C2F0_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">RTA1 domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CC84DRAFT_1153572</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441557">
        <property type="protein sequence ID" value="OAG01615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031980.1">
        <property type="nucleotide sequence ID" value="XM_018176848.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C2F0"/>
    <dbReference type="STRING" id="1460663.A0A177C2F0"/>
    <dbReference type="GeneID" id="28760334"/>
    <dbReference type="InParanoid" id="A0A177C2F0"/>
    <dbReference type="OrthoDB" id="3358017at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007568">
        <property type="entry name" value="RTA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465:SF13">
        <property type="entry name" value="RTA1 DOMAIN PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04479">
        <property type="entry name" value="RTA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="49"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="77"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="121"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="152"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="194"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="230"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="350"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAG01615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="372" mass="41958" checksum="7D8F9DF6F63F463E" modified="2016-09-07" version="1">MGMGDYSPGSIWYYAPNKAAPIVFIVLFFTSGVIHTWQTIRHGSWRTTILLPWAAALMIAGFIIRELGAYHPENLTYLIASTVLIMSGPPVYALINYFILSRILYYIPYLAPMHPGRVATTFVGLDAVCEILIGQGAWRMANSSMTPKQRKLGANLVTASLSLQVALFGSFGLLAAQFHMRANKAKLLSRDLRIVLYVLYVSATIVTIRCIYRLVEYTEGWDSTIYKNEVFFWIFEAIIMFLNTALLNVFHPGKRLPRSNSVFLDRDGVTERRGPGWADDRPWIVTVFDPFDVWGLFTGRDEKTQFWDMSGEELERLRAEKKLNKRNVLAGAVDPFHLWGSRGYIGKHFKSKRAGAGSRATQTTEEAGKPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C3E5</accession>
    <name>A0A177C3E5_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Extracellular metalloproteinase</fullName>
            <ecNumber evidence="13">3.4.24.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Fungalysin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CC84DRAFT_1152385</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="12">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the peptidase M36 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="13"/>
    <dbReference type="EMBL" id="KV441556">
        <property type="protein sequence ID" value="OAG02143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032508.1">
        <property type="nucleotide sequence ID" value="XM_018176799.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C3E5"/>
    <dbReference type="GeneID" id="28760285"/>
    <dbReference type="InParanoid" id="A0A177C3E5"/>
    <dbReference type="OrthoDB" id="3227768at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09596">
        <property type="entry name" value="M36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.170.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="entry name" value="Neutral Protease Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011096">
        <property type="entry name" value="FTP_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050371">
        <property type="entry name" value="Fungal_virulence_M36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001842">
        <property type="entry name" value="Peptidase_M36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33478">
        <property type="entry name" value="EXTRACELLULAR METALLOPROTEINASE MEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33478:SF1">
        <property type="entry name" value="EXTRACELLULAR METALLOPROTEINASE MEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07504">
        <property type="entry name" value="FTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02128">
        <property type="entry name" value="Peptidase_M36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00999">
        <property type="entry name" value="FUNGALYSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 13" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4 13" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 13" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 13" id="KW-0732">Signal</keyword>
    <keyword evidence="8 12 13" id="KW-0862">Zinc</keyword>
    <keyword evidence="10 13" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009361853" description="Extracellular metalloproteinase" evidence="13">
        <location>
            <begin position="20"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="domain" description="FTP" evidence="14">
        <location>
            <begin position="83"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="427"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="241"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="426"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="430"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="456"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR601842-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR601842-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU364017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF07504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OAG02143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="632" mass="69556" checksum="7EEC6E0587909470" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C3P4</accession>
    <name>A0A177C3P4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Iron-sulfur cluster biogenesis chaperone, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CC84DRAFT_1099939</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Required for the assembly of iron-sulfur (Fe/S) clusters in mitochondria. Assisted by the DnaJ-like co-chaperone jac1 and the nucleotide exchange factor mge1, it mediates ATP-dependent Fe-S cluster transfer from the scaffold proteins isu1/isu2 to grx5.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441557">
        <property type="protein sequence ID" value="OAG01408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031773.1">
        <property type="nucleotide sequence ID" value="XM_018174843.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C3P4"/>
    <dbReference type="FunCoup" id="A0A177C3P4">
        <property type="interactions" value="1489"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177C3P4"/>
    <dbReference type="GeneID" id="28758329"/>
    <dbReference type="InParanoid" id="A0A177C3P4"/>
    <dbReference type="OrthoDB" id="2401965at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11733">
        <property type="entry name" value="ASKHA_NBD_HSP70_HSPA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.34.10:FF:000014">
        <property type="entry name" value="Chaperone protein DnaK HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000020">
        <property type="entry name" value="Chaperone protein HscA homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.30:FF:000003">
        <property type="entry name" value="Heat shock protein 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.10:FF:000007">
        <property type="entry name" value="Heat shock protein, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000004">
        <property type="entry name" value="Molecular chaperone DnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000003">
        <property type="entry name" value="Molecular chaperone DnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00332">
        <property type="entry name" value="DnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012725">
        <property type="entry name" value="Chaperone_DnaK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001413">
        <property type="entry name" value="PRK00290.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003520">
        <property type="entry name" value="PRK05183.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02350">
        <property type="entry name" value="prok_dnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="HEAT SHOCK PROTEIN 70KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0346">Stress response</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="641"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="574"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="661"/>
            <end position="671"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00059314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00070638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OAG01408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="671" mass="73001" checksum="607A7A6382385E76" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C4R4</accession>
    <name>A0A177C4R4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">1,3-beta-glucanosyltransferase</fullName>
            <ecNumber evidence="9">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CC84DRAFT_1097616</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Splits internally a 1,3-beta-glucan molecule and transfers the newly generated reducing end (the donor) to the non-reducing end of another 1,3-beta-glucan molecule (the acceptor) forming a 1,3-beta linkage, resulting in the elongation of 1,3-beta-glucan chains in the cell wall.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cell membrane</location>
            <topology evidence="1 9">Lipid-anchor</topology>
            <topology evidence="1 9">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the glycosyl hydrolase 72 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="9"/>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG02623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032988.1">
        <property type="nucleotide sequence ID" value="XM_018174723.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C4R4"/>
    <dbReference type="FunCoup" id="A0A177C4R4">
        <property type="interactions" value="142"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177C4R4"/>
    <dbReference type="GeneID" id="28758209"/>
    <dbReference type="InParanoid" id="A0A177C4R4"/>
    <dbReference type="OrthoDB" id="421038at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042124">
        <property type="term" value="F:1,3-beta-glucanosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071970">
        <property type="term" value="P:fungal-type cell wall (1-&gt;3)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000038">
        <property type="entry name" value="1,3-beta-glucanosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004886">
        <property type="entry name" value="Glucanosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012946">
        <property type="entry name" value="X8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31468">
        <property type="entry name" value="1,3-BETA-GLUCANOSYLTRANSFERASE GAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31468:SF2">
        <property type="entry name" value="1,3-BETA-GLUCANOSYLTRANSFERASE GAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03198">
        <property type="entry name" value="Glyco_hydro_72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07983">
        <property type="entry name" value="X8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00768">
        <property type="entry name" value="X8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 9" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="8 9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <keyword evidence="9 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007948938" description="1,3-beta-glucanosyltransferase" evidence="9">
        <location>
            <begin position="18"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="514"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="domain" description="X8" evidence="11">
        <location>
            <begin position="376"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OAG02623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="536" mass="57144" checksum="2097F7A9D1E1B1E3" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C5V9</accession>
    <name>A0A177C5V9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_920235</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG02806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033171.1">
        <property type="nucleotide sequence ID" value="XM_018187893.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C5V9"/>
    <dbReference type="STRING" id="1460663.A0A177C5V9"/>
    <dbReference type="GeneID" id="28771379"/>
    <dbReference type="InParanoid" id="A0A177C5V9"/>
    <dbReference type="OrthoDB" id="655540at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF8">
        <property type="entry name" value="AMINO ACID TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="135"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="164"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="197"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="238"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="276"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="319"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="354"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="391"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="424"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="7">
        <location>
            <begin position="55"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAG02806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="470" mass="50419" checksum="F2F8CDEA7F8F30F4" modified="2016-09-07" version="1">MADAITSAGAQQYNKDRKANYADSDDMADNNIFGEVTDSQRIKKIAAEGDAHFHRLGWKRLAVVTIVEAIALGALSLPQAYATLGMFPGVFLTITLGCISIFTSYLVGQVKLKYPEIASYADAGRLLLGRVGYEIFGAALVLELLMVVGSHALTGSIALINLNGGHVCSIVFSAVSAVILLILAIPPSFSEVAILGYIDFASIFIAIGITIIATGVQATDSTGGMSSVNWSAWPKDNLTFSEAFVAVSNIIFAFSFAIGQFSFMDEMHTPKEYMKSIWTSGAIQITIYTMTGALCYAFIGMDVQSPALLSAGPLVSKIAFGFALPVIFISGSINTTVALRYIHGRMFKNSVLRYINTVAGWTSWIVLVIIFTIIAWIIAEAIPIFSDLLSLASALFVSGFSFWIPAVMWFCLLKKGSWYAKENLIMSAACMLAFIIGIVTLGAGSYATIADIIKLTSTGTAHSPFTCRST</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C6K8</accession>
    <name>A0A177C6K8_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S30</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CC84DRAFT_1094413</name>
        <name evidence="6" type="ORF">CC84DRAFT_1098811</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS30 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441556">
        <property type="protein sequence ID" value="OAG02377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG04925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032742.1">
        <property type="nucleotide sequence ID" value="XM_018174787.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035290.1">
        <property type="nucleotide sequence ID" value="XM_018174563.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C6K8"/>
    <dbReference type="FunCoup" id="A0A177C6K8">
        <property type="interactions" value="374"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177C6K8"/>
    <dbReference type="GeneID" id="28758049"/>
    <dbReference type="GeneID" id="28758273"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006846">
        <property type="entry name" value="Ribosomal_eS30"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12650">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S30/UBIQUITIN-LIKE PROTEIN FUBI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12650:SF15">
        <property type="entry name" value="RIBOSOMAL PROTEIN S30, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04758">
        <property type="entry name" value="Ribosomal_S30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="28"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAG02377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAG04925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="62" mass="6861" checksum="3EFDA2B763679C0E" modified="2016-09-07" version="1">MGKVHGSLARAGKVKSQTPKVEPQEKKKTPKGRAKKRLTYTRRFVNVTLTGGKRKMNPNPGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C6L4</accession>
    <name>A0A177C6L4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ARM repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CC84DRAFT_1126573</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the importin beta family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441556">
        <property type="protein sequence ID" value="OAG02340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032705.1">
        <property type="nucleotide sequence ID" value="XM_018175747.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C6L4"/>
    <dbReference type="FunCoup" id="A0A177C6L4">
        <property type="interactions" value="1041"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177C6L4"/>
    <dbReference type="GeneID" id="28759233"/>
    <dbReference type="InParanoid" id="A0A177C6L4"/>
    <dbReference type="OrthoDB" id="361693at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000362">
        <property type="entry name" value="Importin 11, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058669">
        <property type="entry name" value="TPR_IPO7/11-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997:SF7">
        <property type="entry name" value="IMPORTIN-11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997">
        <property type="entry name" value="IMPORTIN-7, 8, 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25758">
        <property type="entry name" value="TPR_IPO11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="5">
        <location>
            <begin position="40"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAG02340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="1047" mass="118971" checksum="EF4DA3C1B1EF3B50" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C6N8</accession>
    <name>A0A177C6N8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1178170</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG02532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032897.1">
        <property type="nucleotide sequence ID" value="XM_018180323.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C6N8"/>
    <dbReference type="GeneID" id="28763809"/>
    <dbReference type="InParanoid" id="A0A177C6N8"/>
    <dbReference type="OrthoDB" id="4760831at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG02532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="126" mass="14218" checksum="49AEBA91F549F66A" modified="2016-09-07" version="1">MVSIGRATEFSNWLPPKEKNRQAEENESEILAILDSAYANDSTVTAQTVSKWESASNGNRNRKEKVELLIACTIDRMTELPGEGSFTRALIDASIELLVESGDRSFSTFQFNQRIALDKRRYEEPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2023-06-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C768</accession>
    <name>A0A177C768_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1166377</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG02540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032905.1">
        <property type="nucleotide sequence ID" value="XM_018178947.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C768"/>
    <dbReference type="GeneID" id="28762433"/>
    <dbReference type="InParanoid" id="A0A177C768"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG02540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="100" mass="11581" checksum="CF9DCD0994E60224" modified="2016-09-07" version="1">MPMSSDLAMVITTISLWYSRSCRNFQDPADRRAAVVTTLPRIALAQGDWKHDRRVRHKQEETASQRVRVRYDGLHELTMVNFKSTENDADRRPRPSAIVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C7V0</accession>
    <name>A0A177C7V0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cullin-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_1261591</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the cullin family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG02929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033294.1">
        <property type="nucleotide sequence ID" value="XM_018185079.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C7V0"/>
    <dbReference type="STRING" id="1460663.A0A177C7V0"/>
    <dbReference type="GeneID" id="28768565"/>
    <dbReference type="InParanoid" id="A0A177C7V0"/>
    <dbReference type="OrthoDB" id="27073at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000014">
        <property type="entry name" value="Cullin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000031">
        <property type="entry name" value="Ubiquitin ligase subunit CulD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000035">
        <property type="entry name" value="Ubiquitin ligase subunit CulD, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1310.10">
        <property type="entry name" value="Cullin Repeats"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.130">
        <property type="entry name" value="Cullin, Chain C, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045093">
        <property type="entry name" value="Cullin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059120">
        <property type="entry name" value="Cullin-like_AB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016158">
        <property type="entry name" value="Cullin_homology"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036317">
        <property type="entry name" value="Cullin_homology_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001373">
        <property type="entry name" value="Cullin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019559">
        <property type="entry name" value="Cullin_neddylation_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11932">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00888">
        <property type="entry name" value="Cullin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26557">
        <property type="entry name" value="Cullin_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10557">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00182">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00884">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75632">
        <property type="entry name" value="Cullin homology domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50069">
        <property type="entry name" value="CULLIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Cullin family profile" evidence="7">
        <location>
            <begin position="485"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="24"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="52"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAG02929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="869" mass="99189" checksum="756F589CE4B76125" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C8Y3</accession>
    <name>A0A177C8Y3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1166954</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG03217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033582.1">
        <property type="nucleotide sequence ID" value="XM_018179090.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C8Y3"/>
    <dbReference type="GeneID" id="28762576"/>
    <dbReference type="InParanoid" id="A0A177C8Y3"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG03217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="117" mass="13079" checksum="729C462F28DE2CCC" modified="2016-09-07" version="1">MLRMLRVRLVVRRWQALLGVGMMHVARRASEGAACRGCSMQRSREETLAWSTDWRRARAQSWPCPVREAGAAATRDAARGAVRREGGWRPGWKGDGTRGNSPFSARRLEPALPYTSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C988</accession>
    <name>A0A177C988_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">p-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CC84DRAFT_1166093</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG03946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034311.1">
        <property type="nucleotide sequence ID" value="XM_018178873.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C988"/>
    <dbReference type="STRING" id="1460663.A0A177C988"/>
    <dbReference type="GeneID" id="28762359"/>
    <dbReference type="InParanoid" id="A0A177C988"/>
    <dbReference type="OrthoDB" id="5957327at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033063">
        <property type="term" value="C:Rad51B-Rad51C-Rad51D-XRCC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033065">
        <property type="term" value="C:Rad51C-XRCC3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005657">
        <property type="term" value="C:replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008821">
        <property type="term" value="F:crossover junction DNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000400">
        <property type="term" value="F:four-way junction DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000707">
        <property type="term" value="P:meiotic DNA recombinase assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01393">
        <property type="entry name" value="RecA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052093">
        <property type="entry name" value="HR_Repair_Mediator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014774">
        <property type="entry name" value="KaiC-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020588">
        <property type="entry name" value="RecA_ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46239:SF1">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD51 HOMOLOG 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46239">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD51 HOMOLOG 3 RAD51C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06745">
        <property type="entry name" value="ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50162">
        <property type="entry name" value="RECA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RecA family profile 1" evidence="8">
        <location>
            <begin position="36"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="9"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAG03946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="327" mass="34828" checksum="98D417B1D2C9F1E7" modified="2016-09-07" version="1" fragment="single">MANRDVAMLSSSAPQSSHRLPTVSASQALETLHARGSRTVCTGLPQLDKYLAPHGLPGRAVAGGYVRGKVTEIFGPPGVGKTAFGIQAAVSALREGQKVVWLDAACAPLVPQRFTNVLLADGDPVLQASTAPPKVPGTSRMSPDEMRSHFYHYAIPKLAHLLALFMHPPSSFPPPNTSLIVIDSISTLFDNAYPRNADDRAAKNRSDQARWAAGRKFAVMNELISTLTKLAAMHDIALLLTSQTITRIRAGSRALLVPAISGAEWENGVSTRLVLFRDWVPGQGKWTKADAAKLQKTRFAGVLKANGVGLADDGGVGTVVPFAVEKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C9A4</accession>
    <name>A0A177C9A4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1177440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG03419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033784.1">
        <property type="nucleotide sequence ID" value="XM_018180283.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C9A4"/>
    <dbReference type="GeneID" id="28763769"/>
    <dbReference type="InParanoid" id="A0A177C9A4"/>
    <dbReference type="OrthoDB" id="3934095at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG03419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="193" mass="21787" checksum="A9CC55E0A1DFEF80" modified="2016-09-07" version="1">MEVTERLTNSATPPLPVRNPNRRYSQRKTAFVVPNSSAKLVPKPLFSKRSGIPPLQIHIEVQEILDWSSRSSSQSSGPPSPTSSFRSFASYASSVTTVSGPGSVRERPISQEYAFPPLDICNWGNEWEPSHAPTNPRLRRTKTPKKETLRDLRAKGSDMCLQRVYEQQLELYLNGALFPRTKWKDDLGCVEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CA22</accession>
    <name>A0A177CA22_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF1279 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_798373</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG04594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034959.1">
        <property type="nucleotide sequence ID" value="XM_018187448.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CA22"/>
    <dbReference type="FunCoup" id="A0A177CA22">
        <property type="interactions" value="18"/>
    </dbReference>
    <dbReference type="GeneID" id="28770934"/>
    <dbReference type="InParanoid" id="A0A177CA22"/>
    <dbReference type="OrthoDB" id="426386at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045866">
        <property type="entry name" value="FAM210A/B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009688">
        <property type="entry name" value="FAM210A/B-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21377">
        <property type="entry name" value="PROTEIN FAM210B, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21377:SF0">
        <property type="entry name" value="PROTEIN FAM210B, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06916">
        <property type="entry name" value="FAM210A-B_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="87"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1279" evidence="3">
        <location>
            <begin position="79"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAG04594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="215" mass="24352" checksum="06F5768C72A39D72" modified="2016-09-07" version="1">MASRARLTSAFTRPSWYPFRVPPAAYQQPIRYQSRQSLLHSQYSSRLFRRNYSKKRSTNSHPDPTPHLGSPEPQSFTARLKKLSREYGWTVVGVYLALTVADLPLCFLAVKYVGAERIDHVEHVVVGGAKDLIGRYFPNLFDKGGESDSEIEAAQAEQEEQSGGPTFWTKLGLVFLVHKSFIFIRVPLTAAVTPKVVKTLRGWGYDIGKRKPKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CB13</accession>
    <name>A0A177CB13_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1149876</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG04039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034404.1">
        <property type="nucleotide sequence ID" value="XM_018176685.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CB13"/>
    <dbReference type="GeneID" id="28760171"/>
    <dbReference type="InParanoid" id="A0A177CB13"/>
    <dbReference type="OrthoDB" id="3248909at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021840">
        <property type="entry name" value="DUF3433"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37544:SF3">
        <property type="entry name" value="SPRAY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37544">
        <property type="entry name" value="SPRAY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11915">
        <property type="entry name" value="DUF3433"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="440"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="528"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="570"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="644"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1155"/>
            <end position="1177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG04039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="1260" mass="140293" checksum="92126B5A23781688" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CB53</accession>
    <name>A0A177CB53_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Importin-95</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Karyopherin-95</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CC84DRAFT_1219245</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the importin beta family. Importin beta-1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG04007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034372.1">
        <property type="nucleotide sequence ID" value="XM_018183066.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CB53"/>
    <dbReference type="FunCoup" id="A0A177CB53">
        <property type="interactions" value="1344"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CB53"/>
    <dbReference type="GeneID" id="28766552"/>
    <dbReference type="InParanoid" id="A0A177CB53"/>
    <dbReference type="OrthoDB" id="10263328at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042564">
        <property type="term" value="C:NLS-dependent protein nuclear import complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097718">
        <property type="term" value="F:disordered domain specific binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061676">
        <property type="term" value="F:importin-alpha family protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061608">
        <property type="term" value="F:nuclear import signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006607">
        <property type="term" value="P:NLS-bearing protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051292">
        <property type="term" value="P:nuclear pore complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006656">
        <property type="term" value="P:phosphatidylcholine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046822">
        <property type="term" value="P:regulation of nucleocytoplasmic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060188">
        <property type="term" value="P:regulation of protein desumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000027">
        <property type="entry name" value="Importin subunit beta-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058584">
        <property type="entry name" value="IMB1_TNPO1-like_TPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040122">
        <property type="entry name" value="Importin_beta"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10527">
        <property type="entry name" value="IMPORTIN BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13513">
        <property type="entry name" value="HEAT_EZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25574">
        <property type="entry name" value="TPR_IMB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="10">
        <location>
            <begin position="21"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="9">
        <location>
            <begin position="411"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00079884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00083566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OAG04007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="872" mass="96256" checksum="F884908B7D039CD4" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CBN1</accession>
    <name>A0A177CBN1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Mannan endo-1,6-alpha-mannosidase</fullName>
            <ecNumber evidence="4 10">3.2.1.101</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CC84DRAFT_1177175</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>Random hydrolysis of (1-&gt;6)-alpha-D-mannosidic linkages in unbranched (1-&gt;6)-mannans.</text>
            <dbReference type="EC" id="3.2.1.101"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the glycosyl hydrolase 76 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.101" evidence="4 10"/>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG05064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035429.1">
        <property type="nucleotide sequence ID" value="XM_018180271.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CBN1"/>
    <dbReference type="FunCoup" id="A0A177CBN1">
        <property type="interactions" value="35"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CBN1"/>
    <dbReference type="GeneID" id="28763757"/>
    <dbReference type="InParanoid" id="A0A177CBN1"/>
    <dbReference type="OrthoDB" id="4187847at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008496">
        <property type="term" value="F:mannan endo-1,6-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009272">
        <property type="term" value="P:fungal-type cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.20:FF:000006">
        <property type="entry name" value="Mannan endo-1,6-alpha-mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005198">
        <property type="entry name" value="Glyco_hydro_76"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014480">
        <property type="entry name" value="Mannan-1_6-alpha_mannosidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12145">
        <property type="entry name" value="MANNAN ENDO-1,6-ALPHA-MANNOSIDASE DCW1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12145:SF36">
        <property type="entry name" value="MANNAN ENDO-1,6-ALPHA-MANNOSIDASE DCW1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03663">
        <property type="entry name" value="Glyco_hydro_76"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016302">
        <property type="entry name" value="Man_a_manosd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0732">Signal</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008058066" description="Mannan endo-1,6-alpha-mannosidase" evidence="12">
        <location>
            <begin position="24"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="432"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR016302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OAG05064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="455" mass="49801" checksum="A41465D0F62467FA" modified="2016-09-07" version="1">MKFASSALGALSASALLFSGAGAMDLNLDDPASIKKAAGIAAAGMRKLYTGDRPGDVAGNLPDPYYWWEAGAMFGALIDYWYYTGDDQYNNITVQAMQHQIGQYNAFMPTNQSKSLGNDDQAFWGMAAMSAAENKLPDLPTTGDLAGPSWLALAQAVFNTQAGRWNDKTCGGGLNWQIYQFNNGYTYRNTISNGCYFNIAARLFKYTGNDTYSKEAIKTWNWESRIGLFDKDLHFYDGSDETKNCTDINQIQWTYNLGVHLSGAAAMWNATQDDIWKTRITQMIKTMGDTFFKNDVMYEVACELNGKCNTDQRSFKAYLARWMGYTMLVAPWTKDLMWTKIRTSAAAAAKQCNAAGTNQCGLRWWQDGVNDGSTGVGEQMAAMEIIQNLLITNVSGPVTETKGGTSKSDPSAGGEAENDPIVFSEITTGDKAGAGFLTTIVLIGILAGAWWMVSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CC71</accession>
    <name>A0A177CC71_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1218609</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG05244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035609.1">
        <property type="nucleotide sequence ID" value="XM_018183017.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CC71"/>
    <dbReference type="STRING" id="1460663.A0A177CC71"/>
    <dbReference type="GeneID" id="28766503"/>
    <dbReference type="InParanoid" id="A0A177CC71"/>
    <dbReference type="OrthoDB" id="5420214at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="162"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="235"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG05244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="299" mass="32902" checksum="40E331204CA39E61" modified="2016-09-07" version="1">MEPHLPPAPSAAHHHPPAASRAPVDIGYQYNEKDVFDHRTQYAPRVERGSKGSSNSRAHDSVISYPRSPNVATASPPSPVSSVSSGRKHRSQQSARHSHDAIARVAQPPRAYIDPEKAGSSPYRSRSPTRASASNPDATRQTIAYDPDDFDEKGPEDKPVQLLLYLSLPCALLSFLIMLWTMVALLISLLLQPFRLFSTRSTLPTQLTTFLAPPLNLQLHLIYSFSAADSYSAPMLVVIHLFSPFVAVGVAIAAWTAACFWFFSAILGDPAGQDGHNDGKESILGVRNWWDRWLSRALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CCI9</accession>
    <name>A0A177CCI9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_1187566</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG04519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034884.1">
        <property type="nucleotide sequence ID" value="XM_018180937.1"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CCI9"/>
    <dbReference type="GeneID" id="28764423"/>
    <dbReference type="InParanoid" id="A0A177CCI9"/>
    <dbReference type="OrthoDB" id="2149224at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015631">
        <property type="term" value="F:tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032065">
        <property type="term" value="P:maintenance of protein location in cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13365">
        <property type="entry name" value="PH_PLC_plant-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053005">
        <property type="entry name" value="Nuclear_Pos-Cytoskel_Interact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024774">
        <property type="entry name" value="PH_dom-Mcp5-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28190">
        <property type="entry name" value="NUCLEAR MIGRATION PROTEIN NUM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28190:SF1">
        <property type="entry name" value="NUCLEAR MIGRATION PROTEIN NUM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12814">
        <property type="entry name" value="Mcp5_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="3">
        <location>
            <begin position="1337"/>
            <end position="1448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="129"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="342"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="431"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="733"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="819"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1028"/>
            <end position="1050"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1082"/>
            <end position="1140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1170"/>
            <end position="1296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1452"/>
            <end position="1529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1606"/>
            <end position="1650"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="202"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="258"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="370"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="449"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="511"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="541"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="554"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="667"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="688"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="733"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="828"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="885"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="899"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="914"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="933"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1083"/>
            <end position="1094"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1193"/>
            <end position="1205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1231"/>
            <end position="1243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1283"/>
            <end position="1295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1459"/>
            <end position="1497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1505"/>
            <end position="1526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1628"/>
            <end position="1650"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAG04519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="1650" mass="179964" checksum="05A39BA16AF470DD" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CCK1</accession>
    <name>A0A177CCK1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Tetratricopeptide repeat domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1163918</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG05363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035728.1">
        <property type="nucleotide sequence ID" value="XM_018178363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CCK1"/>
    <dbReference type="FunCoup" id="A0A177CCK1">
        <property type="interactions" value="60"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CCK1"/>
    <dbReference type="GeneID" id="28761849"/>
    <dbReference type="InParanoid" id="A0A177CCK1"/>
    <dbReference type="OrthoDB" id="433738at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051879">
        <property type="term" value="F:Hsp90 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46035">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46035:SF3">
        <property type="entry name" value="TRANSLOCATION PROTEIN SEC72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG05363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="201" mass="21812" checksum="6276BA4F06619506" modified="2016-09-07" version="1">MESADTFTLLPLTMDPATKAISANPANAALQNELEALNALHRGLISAGTPTGTPPPPVPVNPTRSAQIGKLRESGNNEFRKGNHAQAVKLYGLAIDMALGRPHWEPSGLVREEVSGLLSNRAQANMAQQNWPEGAVDAEASVEMKKADNAKGWWRRGKCLLEMGRLEEAETWVRQGLEFGANEPDLVQLKQEIEKRKAGSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CD77</accession>
    <name>A0A177CD77_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1176938</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG04769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035134.1">
        <property type="nucleotide sequence ID" value="XM_018180252.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CD77"/>
    <dbReference type="GeneID" id="28763738"/>
    <dbReference type="InParanoid" id="A0A177CD77"/>
    <dbReference type="OrthoDB" id="3729586at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG04769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="285" mass="32288" checksum="0CD2E77ECC3377A6" modified="2016-09-07" version="1">MFFFQNSIDSLFEENVPSPLYLLPAEIRNMICHEVIFDGTKTLTISLSETGKIILPPLMAVSKQIHSETYGYIVAALRDPATIFEAKVRNYDAKPLLATIKRISQQTGIAQSELVARTQVGFVGTVDMGNLLVWIQGTIANATAHPIFPFEKMDLPSFSGESVFEGRLSLKSHLISYKEFEQRRELCAWTASAREFLTTLEEANLGVLGRPKGEDWRIESNAAIQAAVFNTFAEWHDIFLQKKTIQARVLGQRERKRVEDEHVYVASAMWQFGESLRTVAQRWTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CDG9</accession>
    <name>A0A177CDG9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">ATP synthase subunit d, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CC84DRAFT_1165291</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the ATPase d subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG04932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035297.1">
        <property type="nucleotide sequence ID" value="XM_018178686.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CDG9"/>
    <dbReference type="FunCoup" id="A0A177CDG9">
        <property type="interactions" value="479"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CDG9"/>
    <dbReference type="GeneID" id="28762172"/>
    <dbReference type="InParanoid" id="A0A177CDG9"/>
    <dbReference type="OrthoDB" id="35799at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.280.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008689">
        <property type="entry name" value="ATP_synth_F0_dsu_mt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036228">
        <property type="entry name" value="ATP_synth_F0_dsu_sf_mt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12700">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT D, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05873">
        <property type="entry name" value="Mt_ATP-synt_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005514">
        <property type="entry name" value="ATPase_F0_D_mt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161065">
        <property type="entry name" value="ATP synthase D chain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="5" id="KW-0138">CF(0)</keyword>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 12" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="8 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7 12" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0813">Transport</keyword>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="101"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR005514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OAG04932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="174" mass="19538" checksum="32973DB1CDE3EA06" modified="2016-09-07" version="1">MAVGRSAALKIDWTKIGTQLGLKGQTASALQSFKKRNDDARRKVTLLSEQPQTVDFSHYRSVLKNTAIVDEIEKHFNAFKPQTYDVGRQIKAIEAFEAQAVKDAEQTKTVVDRELSDLQKTLKNIEEARAFDELTVDEVAAAQPDIDKRTEQLVSKGRWAVPGYKEKFGDLSVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CDJ0</accession>
    <name>A0A177CDJ0_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pyrrolo-quinoline quinone</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1188072</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG05301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035666.1">
        <property type="nucleotide sequence ID" value="XM_018180968.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CDJ0"/>
    <dbReference type="STRING" id="1460663.A0A177CDJ0"/>
    <dbReference type="GeneID" id="28764454"/>
    <dbReference type="InParanoid" id="A0A177CDJ0"/>
    <dbReference type="OrthoDB" id="5985073at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008058047" description="Pyrrolo-quinoline quinone" evidence="1">
        <location>
            <begin position="24"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG05301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="552" mass="59023" checksum="03B2A350E40E96DC" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CDZ1</accession>
    <name>A0A177CDZ1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Phosphotransferase</fullName>
            <ecNumber evidence="8">2.7.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CC84DRAFT_1148122</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 1/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the hexokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.-" evidence="8"/>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG05019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035384.1">
        <property type="nucleotide sequence ID" value="XM_018176619.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CDZ1"/>
    <dbReference type="FunCoup" id="A0A177CDZ1">
        <property type="interactions" value="1030"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CDZ1"/>
    <dbReference type="GeneID" id="28760105"/>
    <dbReference type="InParanoid" id="A0A177CDZ1"/>
    <dbReference type="OrthoDB" id="419537at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00180"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005536">
        <property type="term" value="F:D-glucose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008865">
        <property type="term" value="F:fructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004340">
        <property type="term" value="F:glucokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001678">
        <property type="term" value="P:intracellular glucose homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000034">
        <property type="entry name" value="Phosphotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.367.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001312">
        <property type="entry name" value="Hexokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019807">
        <property type="entry name" value="Hexokinase_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022673">
        <property type="entry name" value="Hexokinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022672">
        <property type="entry name" value="Hexokinase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443:SF30">
        <property type="entry name" value="GLUCOKINASE-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443">
        <property type="entry name" value="HEXOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00349">
        <property type="entry name" value="Hexokinase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03727">
        <property type="entry name" value="Hexokinase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00475">
        <property type="entry name" value="HEXOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00378">
        <property type="entry name" value="HEXOKINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51748">
        <property type="entry name" value="HEXOKINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 8" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="5 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="36"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="Hexokinase N-terminal" evidence="11">
        <location>
            <begin position="122"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="Hexokinase C-terminal" evidence="12">
        <location>
            <begin position="341"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="63"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="546"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="79"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="93"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF03727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OAG05019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="637" mass="69245" checksum="0712B167B61A253B" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CE27</accession>
    <name>A0A177CE27_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Kinesin light chain 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1148396</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG05172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035537.1">
        <property type="nucleotide sequence ID" value="XM_018176634.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CE27"/>
    <dbReference type="STRING" id="1460663.A0A177CE27"/>
    <dbReference type="GeneID" id="28760120"/>
    <dbReference type="InParanoid" id="A0A177CE27"/>
    <dbReference type="OrthoDB" id="1658288at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF11">
        <property type="entry name" value="HET-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05729">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13374">
        <property type="entry name" value="TPR_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="2">
        <location>
            <begin position="25"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="NACHT" evidence="1">
        <location>
            <begin position="292"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG05172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="928" mass="105453" checksum="845CF349E74AE6CA" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CEL6</accession>
    <name>A0A177CEL6_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Condensation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_1218555</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG05180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035545.1">
        <property type="nucleotide sequence ID" value="XM_018183010.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CEL6"/>
    <dbReference type="STRING" id="1460663.A0A177CEL6"/>
    <dbReference type="GeneID" id="28766496"/>
    <dbReference type="InParanoid" id="A0A177CEL6"/>
    <dbReference type="OrthoDB" id="3791627at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043041">
        <property type="term" value="P:amino acid activation for nonribosomal peptide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.30">
        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensation_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527:SF16">
        <property type="entry name" value="NONRIBOSOMAL PEPTIDE SYNTHASE ATNA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527">
        <property type="entry name" value="NONRIBOSOMAL PEPTIDE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Condensation" evidence="3">
        <location>
            <begin position="91"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="55"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="55"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAG05180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="242" mass="27011" checksum="A78D096052A9D3BE" modified="2016-09-07" version="1">MKRPVSLEDHIIRFILVKQSENSHRLVLRLSHAQYDRISLPSILQVIKAAYKGTTLSSSKPTPPSSTVSAHKTPANPTHTRPRYSKTRTCTTFATTVKAAWALVLSSLAYTPDTVFGQVISGRIGSLSAIHDVVEPSLNILTVRVPLQHTWTNADLLRFIQNQHVASMPHENYSMRSIIERCTAWPEATRFSSIRQHTNFGKQFFGEVLSASRESEMMGSSPPHDVADVWIWTRPVRGGVLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CEX2</accession>
    <name>A0A177CEX2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1260540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG05348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035713.1">
        <property type="nucleotide sequence ID" value="XM_018184993.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CEX2"/>
    <dbReference type="GeneID" id="28768479"/>
    <dbReference type="InParanoid" id="A0A177CEX2"/>
    <dbReference type="OrthoDB" id="3790934at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="458"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG05348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="491" mass="55146" checksum="209042708C4B4796" modified="2016-09-07" version="1">MPKETRIITRDNIERALKKHDNEITRLFRKLMGTANNPQSQKVKNYKTATDKSRVTMVALQHKFGRNVNDIPSLENKWTKPENKSKTEALQSLVNIVNDNDTLRTLLTNSLKVARNRAVDYYQPVATQRTDTGSTCIKESELEDDSSAENIVEKVMQAKGSLMALPCPDVGGFLEDEIRAKEEKLAQTHIATELPLYSVLPPGYLCGANFTLETHDTYATVLRGEVVWIFWPRTAQNLRVMEQAYQKIIDGTPEEPEALANQLNDGVIFGQPAGRCLRLPPLCIFMCVATEFTVLSRYQLMSASYIVDSLDVPAGFYRSCLGTHGYVRAEQLFRGHSESRREMIERILKCEFETYEPHEWAEHTEIAGPINDLMRKWDEVKGNVAKLLTLKDAAQLRHSWIGLLKVFRSDQCAICGASGKHFSDVGLHFDTAHGFHGDHAALALPDLPAYRVLGDGQSQDPVGDALDDANETPGGDDGGYEYETEDVIHRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CF71</accession>
    <name>A0A177CF71_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Fork-head domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CC84DRAFT_723540</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG05479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035844.1">
        <property type="nucleotide sequence ID" value="XM_018187178.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CF71"/>
    <dbReference type="STRING" id="1460663.A0A177CF71"/>
    <dbReference type="GeneID" id="28770664"/>
    <dbReference type="InParanoid" id="A0A177CF71"/>
    <dbReference type="OrthoDB" id="5954824at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00059">
        <property type="entry name" value="FH_FOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000260">
        <property type="entry name" value="Forkhead transcription factor (Sep1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001766">
        <property type="entry name" value="Fork_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050211">
        <property type="entry name" value="FOX_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018122">
        <property type="entry name" value="TF_fork_head_CS_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030456">
        <property type="entry name" value="TF_fork_head_CS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11829:SF343">
        <property type="entry name" value="FORK-HEAD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11829">
        <property type="entry name" value="FORKHEAD BOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00250">
        <property type="entry name" value="Forkhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00053">
        <property type="entry name" value="FORKHEAD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00339">
        <property type="entry name" value="FH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00657">
        <property type="entry name" value="FORK_HEAD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00658">
        <property type="entry name" value="FORK_HEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50039">
        <property type="entry name" value="FORK_HEAD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fork-head" evidence="6">
        <location>
            <begin position="202"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Fork-head" evidence="4">
        <location>
            <begin position="202"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="35"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="149"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="313"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="721"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="313"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="367"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="439"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="476"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="721"/>
            <end position="735"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAG05479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="750" mass="82259" checksum="55A817E8022100C5" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CF77</accession>
    <name>A0A177CF77_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1205359</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG05592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035957.1">
        <property type="nucleotide sequence ID" value="XM_018181971.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CF77"/>
    <dbReference type="GeneID" id="28765457"/>
    <dbReference type="InParanoid" id="A0A177CF77"/>
    <dbReference type="OrthoDB" id="4851849at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027796">
        <property type="entry name" value="OTT_1508_deam-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14441">
        <property type="entry name" value="OTT_1508_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG05592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="451" mass="50542" checksum="47A06F57F9FA8824" modified="2016-09-07" version="1">MKGDSAPALVRQEIRTAPTERSIWTSVQDETTFRQAAVDLALATGECPWDAHTGLPPSPGAPRIDDYVQLSPPRSESRDQYILSEHIENRLANDLALLAASKEAVFSVTAACIEERADANGHLTGLKLWLAANEGVSEELKGSLAEIWHCQSASTSEGETVSNVFAKIVHLNRLRIYQRVRKAVGHPPIFREKGRTRTNPDDKLARAFMRMPKSRPQDKWKPPALCNELVRRGLSLNVKLLALLESLTVDEIEQGSDHVVRQLETIARDCFNVTTDNGRVPFKHLLGECELDAGLWLRNKYIGEVEKTGAYWRMAMSICRIHRQISGARPKDLPPVKLEIEGVQPYVSVINEPSIQGRPMPCYVHAEVQLITHLAQQEARREFEVSSTQKVITRRPRIIGASKSACFLCFLFLSCYGGPETPATHGRLLRTYVRLFSECILRWSGYGENTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CFF2</accession>
    <name>A0A177CFF2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1205856</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG06334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036699.1">
        <property type="nucleotide sequence ID" value="XM_018182001.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CFF2"/>
    <dbReference type="STRING" id="1460663.A0A177CFF2"/>
    <dbReference type="GeneID" id="28765487"/>
    <dbReference type="InParanoid" id="A0A177CFF2"/>
    <dbReference type="OrthoDB" id="5421784at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="515"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="416"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="482"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="586"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="693"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="586"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="616"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="733"/>
            <end position="747"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG06334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="747" mass="77871" checksum="1F05E294A4335C2B" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CFS9</accession>
    <name>A0A177CFS9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Tat pathway signal sequence</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_1187106</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Mycotoxin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ustYa family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG06061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036426.1">
        <property type="nucleotide sequence ID" value="XM_018180901.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CFS9"/>
    <dbReference type="STRING" id="1460663.A0A177CFS9"/>
    <dbReference type="GeneID" id="28764387"/>
    <dbReference type="InParanoid" id="A0A177CFS9"/>
    <dbReference type="OrthoDB" id="3687641at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021765">
        <property type="entry name" value="UstYa-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365:SF4">
        <property type="entry name" value="CYCLOCHLOROTINE BIOSYNTHESIS PROTEIN O"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365">
        <property type="entry name" value="YALI0B05434P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11807">
        <property type="entry name" value="UstYa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00035112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAG06061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="250" mass="28412" checksum="1895EAA2629141D1" modified="2016-09-07" version="1">MQPKSTNDGETTSFLNRDHIKETARRKGMTYLLLANLFVFTMSMLTLICAVYSQRSQSTYSAARLMDEFGVFSPAMNVVEYKEVEFKLPSPVNTSKYVGVSQDVNNAWLDIAYVPDQMVSVDDFPKLKKPMDSVKVKDPKSDETGYRVGLEVFHQLQCLNLLRMATYPEHYTKLQSDETSKPEETDANSSQDHCVEVLRTKLMCASDVSVFTYHAMPGQQAPMPDYDSKHVCRNFDKIKQWATDNAMPAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CFT8</accession>
    <name>A0A177CFT8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aromatic prenyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1245343</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the tryptophan dimethylallyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG06186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036551.1">
        <property type="nucleotide sequence ID" value="XM_018184180.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CFT8"/>
    <dbReference type="STRING" id="1460663.A0A177CFT8"/>
    <dbReference type="GeneID" id="28767666"/>
    <dbReference type="InParanoid" id="A0A177CFT8"/>
    <dbReference type="OrthoDB" id="3354387at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016765">
        <property type="term" value="F:transferase activity, transferring alkyl or aryl (other than methyl) groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009820">
        <property type="term" value="P:alkaloid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13929">
        <property type="entry name" value="PT-DMATS_CymD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017795">
        <property type="entry name" value="ABBA_NscD-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03429">
        <property type="entry name" value="arom_pren_DMATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40627">
        <property type="entry name" value="INDOLE PRENYLTRANSFERASE TDIB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40627:SF4">
        <property type="entry name" value="PRENYLTRANSFERASE ASQH1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11991">
        <property type="entry name" value="Trp_DMAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG06186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="455" mass="51121" checksum="659477764A5D2909" modified="2016-09-07" version="1">MLSGSACKIFSGIPLQTLLEDRTITSRPPHDVVRSRLEFDQTDSYWWDTTGVVLSKLMTQAGYPLAVHYKALAFLYDNVLQAWGPIPHGTDGQSDGRPWKATFLEDGSNFEPSLNLSATGTTETCVRFTIECNSALSGTSEDILNQKATHALIMRCADALPDFDLTVYNYMVETLMCDDKEALRLIQDFPTCRHPQILFAFDFERSGRILGKCVPFLYWKSHQLGITRKALATKFISGVPEVGPHFAPCLAAWNDFMVSVPAELGGEPTTECMNFDVVKPGKNSRIKIYIRPHKTSFNCAKYFYTLGGLLNDDATLEGIRILRIFYEVLLDIKEGEEDKELTTYQSGSGSLLFNCAFRPGAALPIPQFYITIWKFMPSNAVIMERLTAFWRRIGWNQQAEKYAQDWQDTFPWVNASECGNTTVLSFAYKAGGSGIYQSVYYSPMAHVAAERLGYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CG12</accession>
    <name>A0A177CG12_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Multidrug resistance-associated protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CC84DRAFT_1145217</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG05657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036022.1">
        <property type="nucleotide sequence ID" value="XM_018176498.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A177CG12">
        <property type="interactions" value="283"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CG12"/>
    <dbReference type="GeneID" id="28759984"/>
    <dbReference type="InParanoid" id="A0A177CG12"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18595">
        <property type="entry name" value="ABC_6TM_MRP1_2_3_6_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18603">
        <property type="entry name" value="ABC_6TM_MRP1_2_3_6_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000565">
        <property type="entry name" value="ABC bile acid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000020">
        <property type="entry name" value="ABC metal ion transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000001">
        <property type="entry name" value="ATP-binding cassette subfamily C member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:004222">
        <property type="entry name" value="Os02g0288700 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056227">
        <property type="entry name" value="TMD0_ABC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF443">
        <property type="entry name" value="MULTIDRUG-RESISTANCE LIKE PROTEIN 1, ISOFORM I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24357">
        <property type="entry name" value="TMD0_ABC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="3" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="86"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="121"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="151"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="336"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="437"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="524"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="557"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="963"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1007"/>
            <end position="1034"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1095"/>
            <end position="1121"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="13">
        <location>
            <begin position="300"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="620"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="13">
        <location>
            <begin position="967"/>
            <end position="1251"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="1288"/>
            <end position="1523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="845"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="878"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="900"/>
            <end position="919"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OAG05657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="1535" mass="170915" checksum="8C66F0FF5A7264FB" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CHP1</accession>
    <name>A0A177CHP1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF3074 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1146465</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG06388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036753.1">
        <property type="nucleotide sequence ID" value="XM_018176553.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CHP1"/>
    <dbReference type="STRING" id="1460663.A0A177CHP1"/>
    <dbReference type="GeneID" id="28760039"/>
    <dbReference type="InParanoid" id="A0A177CHP1"/>
    <dbReference type="OrthoDB" id="5403181at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd08864">
        <property type="entry name" value="SRPBCC_DUF3074"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024500">
        <property type="entry name" value="DUF3074"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40370:SF1">
        <property type="entry name" value="DUF3074 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40370">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11274">
        <property type="entry name" value="DUF3074"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3074" evidence="2">
        <location>
            <begin position="119"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="305"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="402"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="458"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="570"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="307"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="323"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="414"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="458"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="477"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="575"/>
            <end position="600"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG06388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="632" mass="69741" checksum="54BA46259DE9FDC9" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CI24</accession>
    <name>A0A177CI24_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1163386</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG07164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037529.1">
        <property type="nucleotide sequence ID" value="XM_018178253.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CI24"/>
    <dbReference type="GeneID" id="28761739"/>
    <dbReference type="InParanoid" id="A0A177CI24"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG07164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="156" mass="18235" checksum="4CDD8EA60D3B96C0" modified="2016-09-07" version="1">MGSRLQPWMQASKHVLLEVLQTIIQTHRIYIPDPETRGRFQDVHKNAFLLSVLLWMEETLLFPIKGARRVALLDDIRSLDMLWIEMTVRGPADVSDKLTMIKDAGERCARQLFKNQGFDDVCVRFESEQLLKRGIWKPKRMEISRMLSVVTPKLEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CJG6</accession>
    <name>A0A177CJG6_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_1143912</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG07401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037766.1">
        <property type="nucleotide sequence ID" value="XM_018176436.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CJG6"/>
    <dbReference type="GeneID" id="28759922"/>
    <dbReference type="InParanoid" id="A0A177CJG6"/>
    <dbReference type="OrthoDB" id="5175824at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13577">
        <property type="entry name" value="SnoaL_4"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008058292" description="SnoaL-like domain-containing protein" evidence="2">
        <location>
            <begin position="22"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="domain" description="SnoaL-like" evidence="3">
        <location>
            <begin position="34"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="SnoaL-like" evidence="3">
        <location>
            <begin position="222"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="SnoaL-like" evidence="3">
        <location>
            <begin position="418"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="554"/>
            <end position="575"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAG07401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="664" mass="73713" checksum="535185FE6C212E02" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CK26</accession>
    <name>A0A177CK26_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Stress responsive A/B barrel domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1163420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG07199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037564.1">
        <property type="nucleotide sequence ID" value="XM_018178259.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CK26"/>
    <dbReference type="GeneID" id="28761745"/>
    <dbReference type="InParanoid" id="A0A177CK26"/>
    <dbReference type="OrthoDB" id="3830014at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013097">
        <property type="entry name" value="Dabb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07876">
        <property type="entry name" value="Dabb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00886">
        <property type="entry name" value="Dabb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51502">
        <property type="entry name" value="S_R_A_B_BARREL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Stress-response A/B barrel" evidence="1">
        <location>
            <begin position="7"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG07199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="110" mass="11931" checksum="981567C7AA563F3C" modified="2016-09-07" version="1">MATPKPITRVTLFKIASSSDAEILLSHYRGMPTNAIKDGKPYLLSVTAGPTFEDPRSQGFNFAAISKFKSKEDMAYYDEECAAHAALKAFAKGVIQGPPQVVYLEDGTAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CKI8</accession>
    <name>A0A177CKI8_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1216357</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG07388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037753.1">
        <property type="nucleotide sequence ID" value="XM_018182794.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CKI8"/>
    <dbReference type="GeneID" id="28766280"/>
    <dbReference type="InParanoid" id="A0A177CKI8"/>
    <dbReference type="OrthoDB" id="8954335at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG07388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="172" mass="18386" checksum="A00336682126E040" modified="2016-09-07" version="1">MQPVFNEPHSHGKIVIVILLLGPSPTGNATFISHLLPSNTSPEPIPTPPPPTTAIASYAADLPNGQCVLLLDTPGFDPSAPFSTRWGVEVVTYISALHARNKSRVCWGGILYFASVEEGTMTPGSMQGVCVVERLCGADMFASVRVVTTGWAAQHPDGRQVKLEHNLQANED</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CKK1</accession>
    <name>A0A177CKK1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CC84DRAFT_1242855</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Mycotoxin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ustYa family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG07369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037734.1">
        <property type="nucleotide sequence ID" value="XM_018184096.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CKK1"/>
    <dbReference type="STRING" id="1460663.A0A177CKK1"/>
    <dbReference type="GeneID" id="28767582"/>
    <dbReference type="InParanoid" id="A0A177CKK1"/>
    <dbReference type="OrthoDB" id="3687641at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021765">
        <property type="entry name" value="UstYa-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365:SF11">
        <property type="entry name" value="TAT PATHWAY SIGNAL SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365">
        <property type="entry name" value="YALI0B05434P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11807">
        <property type="entry name" value="UstYa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00035112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAG07369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="266" mass="30475" checksum="74161929D2E0E524" modified="2016-09-07" version="1">MSLYEDRPSTRNSGPKPSDYSPLAASNEYHDEAEKLLHPGLVTRSPSKCGRAWKWVRLALEIVGLSLLVSNTLMLLNYSQPVTDPDPRVSSGPANKHMMYGSDPRYMSFNHKYDYLWNDAFTESWGLIALPPFKDAAGLYSKDPVHDEGGIGMFHAFHCLASMRTAFQKMNESSVTLEQLQHGDHVAHCFDYLRNVVQCTADDTFELPRNRSGHPWGKIIEGQWDVRTCRDHTRLQEIMDKYGQWRRFDELIYHDEVGVPNEDPEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CL46</accession>
    <name>A0A177CL46_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1185155</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038598.1">
        <property type="nucleotide sequence ID" value="XM_018180789.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CL46"/>
    <dbReference type="GeneID" id="28764275"/>
    <dbReference type="InParanoid" id="A0A177CL46"/>
    <dbReference type="OrthoDB" id="3781356at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG08233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="529" mass="59180" checksum="1CAE334E34FE0353" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CME4</accession>
    <name>A0A177CME4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Endosomal/vacuolar adapter protein YPT35</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">PX domain-containing protein YPT35</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CC84DRAFT_1215160</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Recruits the lipid transfer protein VPS13 to endosomal and vacuolar membranes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the YPT35 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039048.1">
        <property type="nucleotide sequence ID" value="XM_018182699.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CME4"/>
    <dbReference type="STRING" id="1460663.A0A177CME4"/>
    <dbReference type="GeneID" id="28766185"/>
    <dbReference type="InParanoid" id="A0A177CME4"/>
    <dbReference type="OrthoDB" id="10254720at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07280">
        <property type="entry name" value="PX_YPT35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037917">
        <property type="entry name" value="Ypt35_PX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10555:SF170">
        <property type="entry name" value="FI18122P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10555">
        <property type="entry name" value="SORTING NEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0967">Endosome</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0926">Vacuole</keyword>
    <feature type="domain" description="PX" evidence="11">
        <location>
            <begin position="73"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00033728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00033785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OAG08683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="207" mass="23009" checksum="2EB4A13DE30F2223" modified="2016-09-07" version="1">MESRDAPARDEPATATAAARPERSSIVPPYWQRHERNASRQSSYSVEARDPIRLEDHTDEGSEQCKALWAKHVTIDDYVVVGSGTTPALGAYVVWNITVDTLNVSAVVAPSSSPCCLGHSTDPSFDQGSPMKIIKRYSDFDDLRQKLVQTFPHLVGAMPPLPPKSIVSRFRSKFLEKRRVGLAHFLNCILLNPEFAGSPVLKEFLFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CMW1</accession>
    <name>A0A177CMW1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1174077</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038991.1">
        <property type="nucleotide sequence ID" value="XM_018180072.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CMW1"/>
    <dbReference type="GeneID" id="28763558"/>
    <dbReference type="InParanoid" id="A0A177CMW1"/>
    <dbReference type="OrthoDB" id="3795368at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="60"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG08626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="382" mass="42933" checksum="58FFDBFCA5CB51F2" modified="2016-09-07" version="1">MRPKRCNASSSLCTNNLLDVYITKSVLPQEHSTNNHEPEMANLIPSSFLSDVAFATHNKYVGISLAGKGFTAEVWYAIPRSAFGSINHPADVGLLRSHICAVKLYKLYSPQIYLKNELPAMKRLQTIPDELRARFTEPLDFSEAESDNERCWVAMKAIPGFTLTQLRGAALLSKKVVPQEFVFHMYIQLHKALKFLHTSDPPMTKGDLVAVNVMIDPSTQDVPGFPNIKLIDFGGAQVGKIGVPLSKHAMDSEWNWMYRMMYDLALLNHTCEYTNESVFTTGGGNERNCTHEIDFSDFIDTLGYALAAGRRLDESNLEQEMNLQERLPRVLKIRRDFACPEALQAIERLLEGTGKSINNKFPTDQQILDVLSERTSTSSSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CNR0</accession>
    <name>A0A177CNR0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">3-ketoacyl-reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_1115613</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039206.1">
        <property type="nucleotide sequence ID" value="XM_018175430.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CNR0"/>
    <dbReference type="STRING" id="1460663.A0A177CNR0"/>
    <dbReference type="GeneID" id="28758916"/>
    <dbReference type="InParanoid" id="A0A177CNR0"/>
    <dbReference type="OrthoDB" id="5840532at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006393">
        <property type="entry name" value="PRK08642.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43639">
        <property type="entry name" value="OXIDOREDUCTASE, SHORT-CHAIN DEHYDROGENASE/REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_5G02870)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43639:SF1">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAG08841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="253" mass="26612" checksum="7F591ACEB25B0B29" modified="2016-09-07" version="1" fragment="single">MSTLQDDLVLITGSSRGLGLAIARAFHAHGAQIVLNYISPTSATPTSTIAQELSAIAIQADVTDPTAVRSLFAQAEAHYNRPISVVVNNALAPFSFNGDARQKIEDITWSSFDAQLKGAVQAALNTTQAALPGFETLGHGRIINIGSNLVQHPVVPYHDYTSAKGALLAFTRTCAAELGPKNITVNMVSGGLLRVTDASRETPEEVFESVQAATPLRRVTTPEEVSGAVLFFASAWGRGVTGQNLGVDGGLVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CPI1</accession>
    <name>A0A177CPI1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sec1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1162680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the STXBP/unc-18/SEC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039203.1">
        <property type="nucleotide sequence ID" value="XM_018178061.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CPI1"/>
    <dbReference type="FunCoup" id="A0A177CPI1">
        <property type="interactions" value="727"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CPI1"/>
    <dbReference type="GeneID" id="28761547"/>
    <dbReference type="InParanoid" id="A0A177CPI1"/>
    <dbReference type="OrthoDB" id="10262287at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.830.10">
        <property type="entry name" value="Syntaxin Binding Protein 1, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043154">
        <property type="entry name" value="Sec-1-like_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043127">
        <property type="entry name" value="Sec-1-like_dom3a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001619">
        <property type="entry name" value="Sec1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027482">
        <property type="entry name" value="Sec1-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036045">
        <property type="entry name" value="Sec1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043155">
        <property type="entry name" value="VPS33_dom3b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11679">
        <property type="entry name" value="VESICLE PROTEIN SORTING-ASSOCIATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00995">
        <property type="entry name" value="Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56815">
        <property type="entry name" value="Sec1/munc18-like (SM) proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG08838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="658" mass="71668" checksum="0390445A39BD1EBB" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CPX9</accession>
    <name>A0A177CPX9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1162793</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039357.1">
        <property type="nucleotide sequence ID" value="XM_018178100.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CPX9"/>
    <dbReference type="STRING" id="1460663.A0A177CPX9"/>
    <dbReference type="GeneID" id="28761586"/>
    <dbReference type="InParanoid" id="A0A177CPX9"/>
    <dbReference type="OrthoDB" id="4991875at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40640">
        <property type="entry name" value="ANCHORED GLYCOPROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G04860)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40640:SF1">
        <property type="entry name" value="ANCHORED GLYCOPROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G04860)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008058449" evidence="2">
        <location>
            <begin position="20"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="177"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="199"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG08992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="241" mass="23693" checksum="FDC4FA9F27C818BA" modified="2016-09-07" version="1">MYAKTSIAALFGAIVAVSAQSTTPSSAAAKATGTILSVLVPGADNMTLVGSIIEVKSALTTLAVTCPSGTDSNDCGMPEEGMTITQGPKTVVMSTVMPEESGSPIVVNYGWACSLGGTTTAECTYSAIPSVTGSVDPSILSEYNAQMTAQSSTTKLGGEELKSVMFPVTITAGAEKLSQTGNAETSSSASGTKTGNAEASSNVSGSKTGSASSPTATPGAASSVKMGGFALGGALAAVFML</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CQ18</accession>
    <name>A0A177CQ18_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SMP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_436246</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG09406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039771.1">
        <property type="nucleotide sequence ID" value="XM_018186261.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CQ18"/>
    <dbReference type="STRING" id="1460663.A0A177CQ18"/>
    <dbReference type="GeneID" id="28769747"/>
    <dbReference type="InParanoid" id="A0A177CQ18"/>
    <dbReference type="OrthoDB" id="3941683at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008058457" description="SMP domain-containing protein" evidence="1">
        <location>
            <begin position="17"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG09406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="178" mass="18033" checksum="3C11F7F2645BCE01" modified="2016-09-07" version="1">MLSHTVLLALVAAVGAVPLNINLGAYSPALVVGDGEISLGAAGAAAGAAAQQAKRGNLVRDINEILKKREAAPEPTELAHIDAVSRAVEWIKRDINSFNAALGYAERAQQNQPKIELGTGAEGSGVGITVNAGLNVPANSAANGAAAPKAAGRAVKRSEEVVDEAEAPKMTLVAITEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CQ87</accession>
    <name>A0A177CQ87_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Autophagy-related protein 14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CC84DRAFT_601456</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATG14 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG09060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039425.1">
        <property type="nucleotide sequence ID" value="XM_018186844.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CQ87"/>
    <dbReference type="GeneID" id="28770330"/>
    <dbReference type="InParanoid" id="A0A177CQ87"/>
    <dbReference type="OrthoDB" id="16772at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000323">
        <property type="term" value="C:lytic vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035493">
        <property type="term" value="P:SNARE complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018791">
        <property type="entry name" value="UV_resistance/autophagy_Atg14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15157:SF13">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15157">
        <property type="entry name" value="UV RADIATION RESISTANCE-ASSOCIATED GENE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10186">
        <property type="entry name" value="ATG14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="272"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="386"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="512"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="94"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="290"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="520"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAG09060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="532" mass="60538" checksum="DA83CDF62DD0E994" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CQ97</accession>
    <name>A0A177CQ97_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6590 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1137555</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG09693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040058.1">
        <property type="nucleotide sequence ID" value="XM_018176152.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CQ97"/>
    <dbReference type="STRING" id="1460663.A0A177CQ97"/>
    <dbReference type="GeneID" id="28759638"/>
    <dbReference type="InParanoid" id="A0A177CQ97"/>
    <dbReference type="OrthoDB" id="3559580at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046497">
        <property type="entry name" value="DUF6590"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35391">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35391:SF5">
        <property type="entry name" value="DUF6590 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20233">
        <property type="entry name" value="DUF6590"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6590" evidence="2">
        <location>
            <begin position="201"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG09693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="386" mass="42951" checksum="A169E2A863768210" modified="2016-09-07" version="1">MDDHEWTWSEKFQDYYRWQLRNVPGKARYDLKWGRSLISRDEQSPSSVNTSLPPSTAEQSDNARNAIVPGTNNSTLPYQLSSVNFPSISEVQDQYQPPEFIQLDPTFRGNNSSPSFSYQRLARPLGSEDTLSTTGPGINTPTTSADTSRLSYSTPGSEQGTGRYDDDTVRTASPDQDMTSRLGTLSLTHETGFETIRNPRAYFKKGRVFKVSWPEPRGEMGPSTSLSAVSIRADTPTQLSLPQTHGALDSTSVLDGMSGGTTLHVKTRMFVVIRQRAQHCLCLPIYTYSQQGTSKAGVKPEDHAPLIKENTELILHPEEQGSKLQRPIVLILEDTTLQWSPLSRINISKVQSVEYNLKVKTVGRISPDCLSDLETMFRDAIGLSED</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CQB0</accession>
    <name>A0A177CQB0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1137049</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG09411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039776.1">
        <property type="nucleotide sequence ID" value="XM_018176127.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CQB0"/>
    <dbReference type="STRING" id="1460663.A0A177CQB0"/>
    <dbReference type="GeneID" id="28759613"/>
    <dbReference type="InParanoid" id="A0A177CQB0"/>
    <dbReference type="OrthoDB" id="9978720at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12809">
        <property type="entry name" value="Esterase_713_like-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050228">
        <property type="entry name" value="Carboxylesterase_BioH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43194:SF4">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43194">
        <property type="entry name" value="HYDROLASE ALPHA/BETA FOLD FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG09411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="351" mass="38538" checksum="70C9CD57FC37E0F2" modified="2016-09-07" version="1">MAFHSYRDVSARREVLYVGGEYTTNIDGTPAQYMTGQIYVEKLTPSTESSKCPIVFIAGAGQTGTNWLHTPDGRPGWAHFFLGHGYTVYLTDQPSRGRSARHPSIGKMRALSTSVVESSFTAISSHNNWPQSKLHTQWPGIGKVGDPVFDAFYASQVPMRVDKLAAENENAKAYSALLDRIGEAYLITHSQAGPYGWRIGDARPQLVKGIVALEPRGPPCETSYPFPGQRIAFGIADGELEYDPPAGPNGEHLKTVKVPAKSANHDECTLQADPPKKLKNLSSIPVLVVTSEASFHALFDYNTVLYLEQAGVNVEHADLPAEGIRGNGHMFFMELNNMVIAERILTWLTKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CQC9</accession>
    <name>A0A177CQC9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Amino acid transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CC84DRAFT_1085546</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG09158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039523.1">
        <property type="nucleotide sequence ID" value="XM_018174106.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CQC9"/>
    <dbReference type="STRING" id="1460663.A0A177CQC9"/>
    <dbReference type="GeneID" id="28757592"/>
    <dbReference type="InParanoid" id="A0A177CQC9"/>
    <dbReference type="OrthoDB" id="5982228at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050598">
        <property type="entry name" value="AminoAcid_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785:SF382">
        <property type="entry name" value="LOW-AFFINITY METHIONINE PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="145"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="169"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="223"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="261"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="315"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="391"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="423"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAG09158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="467" mass="51107" checksum="32FBD182827439C0" modified="2016-09-07" version="1">MRKEYTPSRQEKLRSFTVMCLIFNRSIGSGIFVTPAKILRATQSVGINIIFWAVGGFITICGILVWLEFGLSIPREHVDGKDRAVPRSGGEKNYLEWVLRKPKFLATCMYGIAFVILGNLSGNAVAFGRYVLLAAGHEDPGKGPVIGIAIGALTVVALLHAISRRGGIVVNNCFAVLKIGILLTIIILGFTVQGGKNFNSEGARSHGSTFKPGDTFSDPSRALASYTTTFLYVLYTYSGFEQPFYVLSEVHRPRKYFARAVVSALAILTLLFVLVNIAYMCVIPLDFILDPKNASTDITSMFFELVFGNDTAKRIMQALVAFSILGNLIVMTFTATRVKQEIAKEGILPKSLWLATSRTTPTAKLLNRITKNEVNGGGATDGDEHLEQSPMAALGLHWVSSVFLLAVTSALKVDDSYNFLVSLYAYVLISLMGFCTSLGLLYSKYIRKDFLSQQPPLGGPAAAMIYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CRG6</accession>
    <name>A0A177CRG6_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Rhomboid-type serine protease</fullName>
            <ecNumber evidence="10">3.4.21.105</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CC84DRAFT_1110696</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Serine protease involved in intramembrane proteolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>Cleaves type-1 transmembrane domains using a catalytic dyad composed of serine and histidine that are contributed by different transmembrane domains.</text>
            <dbReference type="EC" id="3.4.21.105"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Membrane</location>
            <topology evidence="2 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the peptidase S54 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.105" evidence="10"/>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG09359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039724.1">
        <property type="nucleotide sequence ID" value="XM_018175263.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CRG6"/>
    <dbReference type="STRING" id="1460663.A0A177CRG6"/>
    <dbReference type="GeneID" id="28758749"/>
    <dbReference type="InParanoid" id="A0A177CRG6"/>
    <dbReference type="OrthoDB" id="2146116at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002610">
        <property type="entry name" value="Peptidase_S54_rhomboid-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022764">
        <property type="entry name" value="Peptidase_S54_rhomboid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22936:SF69">
        <property type="entry name" value="RHOMBOID-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22936">
        <property type="entry name" value="RHOMBOID-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01694">
        <property type="entry name" value="Rhomboid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 10" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0720">Serine protease</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="146"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="275"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="307"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="333"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="364"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="454"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S54 rhomboid" evidence="12">
        <location>
            <begin position="266"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="26"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="44"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="57"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OAG09359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="530" mass="58448" checksum="DAAE5EDD3A00F425" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CRK7</accession>
    <name>A0A177CRK7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acyl-CoA thioesteras-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_1138460</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the C/M/P thioester hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040529.1">
        <property type="nucleotide sequence ID" value="XM_018176195.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CRK7"/>
    <dbReference type="STRING" id="1460663.A0A177CRK7"/>
    <dbReference type="GeneID" id="28759681"/>
    <dbReference type="InParanoid" id="A0A177CRK7"/>
    <dbReference type="OrthoDB" id="68328at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005782">
        <property type="term" value="C:peroxisomal matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:fatty acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006637">
        <property type="term" value="P:acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009062">
        <property type="term" value="P:fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03444">
        <property type="entry name" value="Thioesterase_II_repeat1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03445">
        <property type="entry name" value="Thioesterase_II_repeat2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.210">
        <property type="entry name" value="Acyl-CoA thioesterase, double hotdog domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042171">
        <property type="entry name" value="Acyl-CoA_hotdog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003703">
        <property type="entry name" value="Acyl_CoA_thio"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049449">
        <property type="entry name" value="TesB_ACOT8-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11066">
        <property type="entry name" value="ACYL-COA THIOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11066:SF64">
        <property type="entry name" value="ACYL-COA THIOESTERASE (AFU_ORTHOLOGUE AFUA_1G12060)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13622">
        <property type="entry name" value="4HBT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA thioesterase-like N-terminal HotDog" evidence="3">
        <location>
            <begin position="43"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAG10164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="373" mass="42097" checksum="65D98D2982CDE9A5" modified="2016-09-07" version="1">MAPRSYYDDQGRALPFDQVMQLEKIDDGTFRSVTKAYSPTGGENGTYGGHVYAQAVWAAAQTVEDGFLIHNVTGWFTLGGHPSEHFVYTVNKVRDGYNYCTRSVTVTQAAEKGIMFTCTCSFKREETSPVDYQAICDIRERFREVLEGKEDEPMGHEAAPSQDSAFFRETYLPQHPDHFNPIAGLHLRKVDMRKYNEPRAPIDRRQLTFYTLRGSLPLPTAPYPPSLQGAFRLAREANLHACAHLYASDRNSLFIIPNHLGRAREFTRMASLSHTVIFHVGIRDLIMPPEPRIPHPNAVPTLFEDGPLPLCNLEGNSGGDRDGRKWFVQESWLTRAAGGRGLHTSRLWDYESGTHLATTIQDGLIRFKPETKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CRR8</accession>
    <name>A0A177CRR8_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1082351</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG09459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039824.1">
        <property type="nucleotide sequence ID" value="XM_018173976.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CRR8"/>
    <dbReference type="STRING" id="1460663.A0A177CRR8"/>
    <dbReference type="GeneID" id="28757462"/>
    <dbReference type="InParanoid" id="A0A177CRR8"/>
    <dbReference type="OrthoDB" id="5386682at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF64">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26639">
        <property type="entry name" value="Het-6_barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="45"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG09459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="583" mass="65271" checksum="051985090EAE6396" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CSF3</accession>
    <name>A0A177CSF3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">FAR-17a/AIG1-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1137849</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG09862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040227.1">
        <property type="nucleotide sequence ID" value="XM_018176168.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CSF3"/>
    <dbReference type="STRING" id="1460663.A0A177CSF3"/>
    <dbReference type="GeneID" id="28759654"/>
    <dbReference type="InParanoid" id="A0A177CSF3"/>
    <dbReference type="OrthoDB" id="419711at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12242:SF1">
        <property type="entry name" value="MYND-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12242">
        <property type="entry name" value="OS02G0130600 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="173"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="214"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="254"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="255"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG09862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="279" mass="32134" checksum="AFEA5A56CBA76222" modified="2016-09-07" version="1">MAIWKRQTSGHNGAFDPTYRFSTSWILPPGVLFFARALLSLYAFATLFYIFGWNGAHGRNIDSRRSFSFFTILTYWGLAFYFAFAAAHTGSYWLTGRPFLNRWFAPLRWAHSAFYSTITVYPFIVTAVFWALLAPKNGFASTKDLWSNTSQHALNSFYALFEIVIPRTEPLPFLHMIVIVFILALYLSLAYLTHALQGWYTYDFLNLDKHSSGVVAGYIVGILVGSLIIFLIVRYLILLRMWLTEKKLGKTGKFSNRDHRSMRDEEVGKHEEMHSMGVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CSM5</accession>
    <name>A0A177CSM5_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Peroxidase</fullName>
            <ecNumber evidence="10">1.11.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CC84DRAFT_1202518</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2 a phenolic donor + H2O2 = 2 a phenolic radical donor + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:56136"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:139520"/>
            <dbReference type="ChEBI" id="CHEBI:139521"/>
            <dbReference type="EC" id="1.11.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the peroxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.-" evidence="10"/>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG09942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040307.1">
        <property type="nucleotide sequence ID" value="XM_018181781.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CSM5"/>
    <dbReference type="STRING" id="1460663.A0A177CSM5"/>
    <dbReference type="GeneID" id="28765267"/>
    <dbReference type="InParanoid" id="A0A177CSM5"/>
    <dbReference type="OrthoDB" id="2113341at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140825">
        <property type="term" value="F:lactoperoxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002016">
        <property type="entry name" value="Haem_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024589">
        <property type="entry name" value="Ligninase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000823">
        <property type="entry name" value="Peroxidase_pln"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019794">
        <property type="entry name" value="Peroxidases_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019793">
        <property type="entry name" value="Peroxidases_heam-ligand_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31517">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31517:SF48">
        <property type="entry name" value="PEROXIDASE 16-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00141">
        <property type="entry name" value="peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11895">
        <property type="entry name" value="Peroxidase_ext"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00458">
        <property type="entry name" value="PEROXIDASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00461">
        <property type="entry name" value="PLPEROXIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00435">
        <property type="entry name" value="PEROXIDASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00436">
        <property type="entry name" value="PEROXIDASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50873">
        <property type="entry name" value="PEROXIDASE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0349">Heme</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 10 12" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007948982" description="Peroxidase" evidence="10">
        <location>
            <begin position="21"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="Plant heme peroxidase family profile" evidence="11">
        <location>
            <begin position="49"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OAG09942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="285" mass="30768" checksum="D6B97FBD28FFF134" modified="2016-09-07" version="1">MRQFISSILSASFLAALSVSEESCWPEWSGLASDFETLFIEDETCSDAARAAIRLAFHDCFPGSCDGSIINANECTERVENTQMVRICGTLGEKADEYGLGTADVIQFAADAPAIGLASCSGGPVISFYSGRPDSFLPTPLGMMPNATTDARTMVDLFAQHNFSKTELVALTGAHTIGRQLDGTDMDNTPGEWDHKFYSETSSNSAPQPVAADTFLAQDGETGEEWRAVGKTQESFKDAFIPAMEKLSLMGSNKDHMTDCSGVVQSYAGRAKGRRRVLLKGKRLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CSW9</accession>
    <name>A0A177CSW9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1172470</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG09990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040355.1">
        <property type="nucleotide sequence ID" value="XM_018179982.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CSW9"/>
    <dbReference type="GeneID" id="28763468"/>
    <dbReference type="InParanoid" id="A0A177CSW9"/>
    <dbReference type="OrthoDB" id="3795504at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="134"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="15"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="55"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG09990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="593" mass="64797" checksum="185BEFB3EA0025D4" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CTH1</accession>
    <name>A0A177CTH1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">EDC4-like protein pdc1 beta-propeller domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CC84DRAFT_1184747</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041200.1">
        <property type="nucleotide sequence ID" value="XM_018180771.1"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CTH1"/>
    <dbReference type="GeneID" id="28764257"/>
    <dbReference type="InParanoid" id="A0A177CTH1"/>
    <dbReference type="OrthoDB" id="21128at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031087">
        <property type="term" value="P:deadenylation-independent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.100">
        <property type="entry name" value="conserved c-terminal region of ge- 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055393">
        <property type="entry name" value="Beta-prop_EDC4L"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045152">
        <property type="entry name" value="EDC4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044938">
        <property type="entry name" value="EDC4_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15598">
        <property type="entry name" value="ENHANCER OF MRNA-DECAPPING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15598:SF5">
        <property type="entry name" value="ENHANCER OF MRNA-DECAPPING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24106">
        <property type="entry name" value="Beta-prop_EDC4L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="EDC4-like protein pdc1 beta-propeller" evidence="6">
        <location>
            <begin position="464"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="217"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="573"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="920"/>
            <end position="1053"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="27"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="50"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="74"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="90"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="134"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="217"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="242"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="582"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="942"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1023"/>
            <end position="1049"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF24106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAG10835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="1464" mass="159104" checksum="B2029C6CF0464288" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CTM8</accession>
    <name>A0A177CTM8_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">YAG7-like dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_1161710</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041248.1">
        <property type="nucleotide sequence ID" value="XM_018177814.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CTM8"/>
    <dbReference type="STRING" id="1460663.A0A177CTM8"/>
    <dbReference type="GeneID" id="28761300"/>
    <dbReference type="InParanoid" id="A0A177CTM8"/>
    <dbReference type="OrthoDB" id="5399559at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058602">
        <property type="entry name" value="YAG7_dimerisation_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26434">
        <property type="entry name" value="YAG7_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YAG7-like dimerisation" evidence="3">
        <location>
            <begin position="177"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="271"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="313"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="121"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="313"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="362"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="387"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="427"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="446"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF26434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAG10883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="465" mass="48624" checksum="D3C3A930161C8EF0" modified="2016-09-07" version="1">MGADIVANPPPSASGESKSSRKKRAKAEAASATPTLPTADKATSELGANSSDVAGKANGGEDNLYIRELQKNVRNVNKKLNAMSKVTEIVAANPDVSLDELVSTRKINADQRAQYQKRPALQSQLAQFEEQLAAYKKFEEELQSKAAQEKEILQKGHSEELVKLRDTLKEEAALEVKKTFREQFLTLSRFLRAAAARRQLPEDDSNELTKAFEGALLQVYGGDPSAVAAAEKLIEGSHDSVPSTDGEILSVTYAQVKQAALEEAPFAAEEAWADDVAQSQPTAPETDSPAAISTDPTVAHAGLTEIGTTTGTVTGAELDTSNAPAASSVDAGAANQAGGDWDKPGPGSDDPLAESFEIVPRNPAETETPAAPAAVNVTQSWADDTPEAAPAAPADDGFQSVSHNRGRGRGGHQGEGRGGYRGRGRGGPRGDFGGRGRGGRGRGDGFRGGPRGGGFRGGRGDSSQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CTR3</accession>
    <name>A0A177CTR3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1161255</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040655.1">
        <property type="nucleotide sequence ID" value="XM_018177686.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CTR3"/>
    <dbReference type="GeneID" id="28761172"/>
    <dbReference type="InParanoid" id="A0A177CTR3"/>
    <dbReference type="OrthoDB" id="4158189at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG10290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="146" mass="15662" checksum="24E6726FA1794922" modified="2016-09-07" version="1">MCNGSSTRVSQGGSIAVLRPSREIREVSPVQQDSEVRLLFSNGSRTLLGSAGTHVELQGWDATNSIFQRRSWVVIHSDGDLSAAETRPAVPFFSFDIGSRESCTMELPETLNLGVGDTGIIGRRVSVMTGSTRGPLIVAEGIIGWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CTU3</accession>
    <name>A0A177CTU3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HET-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1139297</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040976.1">
        <property type="nucleotide sequence ID" value="XM_018176233.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CTU3"/>
    <dbReference type="STRING" id="1460663.A0A177CTU3"/>
    <dbReference type="GeneID" id="28759719"/>
    <dbReference type="InParanoid" id="A0A177CTU3"/>
    <dbReference type="OrthoDB" id="20872at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058525">
        <property type="entry name" value="DUF8212"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF10">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26640">
        <property type="entry name" value="DUF8212"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="1">
        <location>
            <begin position="389"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG10611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="470" mass="53137" checksum="E131064736D66B41" modified="2016-09-07" version="1">MWLLSVDSLELKEFIGTDIPPYAILSHTWGAEEVSFVEMKKKKYRDQAKAKAGFSKIGGCCARAKKDGYNWAWVDSCCIDKRSSAELSEAINSMFPWYKHSEICYVYLSDVPGGLYDYDTLANSKWFTRGWTLQELLAPCKILFFAQDWTVFGQIGNFNSWVSRITQIPEPFITGQKRLEQACVSQRMFWASSRKTSRPEDWAYSLMGLFGIHMPIIYGEGLEKAFVRLQQEIFSTTPDQSIFAWYISGMTTFRLLANTPACFRNSGNVRRLGQEIQRSKAENSSFHMTNLGLQITLPIYSNKGNGFKKQREATLNCQVEDKNGNPRQLSLALSYLDSEMGGRVIYMCRRPDTWTFSSKMGHPTSICIRGIGYDASEPEPPPAPPRGALSAGNIMEQCLSIISSATNIDKKTLEDGLTFSEIGADSFALVEVMFLIKHNLGVEVDMYDFYANPSIGMFICHVMLEWEGKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CU08</accession>
    <name>A0A177CU08_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fatty acid desaturase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_515498</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG11025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041390.1">
        <property type="nucleotide sequence ID" value="XM_018186569.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CU08"/>
    <dbReference type="STRING" id="1460663.A0A177CU08"/>
    <dbReference type="GeneID" id="28770055"/>
    <dbReference type="InParanoid" id="A0A177CU08"/>
    <dbReference type="OrthoDB" id="1461976at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03507">
        <property type="entry name" value="Delta12-FADS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012171">
        <property type="entry name" value="Fatty_acid_desaturase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32100">
        <property type="entry name" value="OMEGA-6 FATTY ACID DESATURASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="298"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="328"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid desaturase" evidence="3">
        <location>
            <begin position="134"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="471"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="20"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAG11025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="497" mass="54975" checksum="D1AFC67680C862D1" modified="2016-09-07" version="1">MATTARPQNPVLKRNITTDSAISSSAPSASASPFDSPTGSASNTSLSSLGSDDNVNVKNTRGTLLDGYGNEFQIPDYTIKDIRDAIPKHCFERSGLRGLGYVARDIACLAATFYLFHNYVTPETIASKPLRAALWAGYTVIQGLFGTGLWVMAHECGHQSFSPSKVLNDTVGFIAHTALLVPYFSWKISHGKHHKATGHMERDMVFVPKTREQYASRVGKFAHELHELTEETPIATLIHSVLQQLGGWPMYLIANVTGHNYHERQHEGKGKGKKNGFFGGVNHFNPASPLYEKKDEHLILASDVGLAVVIGTLWYIGKTFGFSNLFVWYIMPYLWVNHWLVAITFLQHTDPTLPHYDAQTWTYTRGAAATIDREFGFVGRTLLHGIIETHVLHHYVSTIPFYHADEATDAIKKVMGRHYRSDTEGGSLGFLQAMWKSARWCHWVEPSEGAQGEGKGVLFFRNRNGLGTAPVKMSAPVAKPTAGKTAKMQIGADSDNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2023-06-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CUI9</accession>
    <name>A0A177CUI9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1161561</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041043.1">
        <property type="nucleotide sequence ID" value="XM_018177773.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CUI9"/>
    <dbReference type="GeneID" id="28761259"/>
    <dbReference type="InParanoid" id="A0A177CUI9"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG10678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="110" mass="12103" checksum="6E65E7CA26D0DD33" modified="2016-09-07" version="1">MPILVKSGHIYGSADILPAQFAFGERKLVRRRLDFLHKRRGVARGTLNTGPRKPVILWTLVLCSALAGSTLAKSSSSQARVTHVEVTDITHVSCSGEWTYNLAGELRDFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CUL0</accession>
    <name>A0A177CUL0_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tat pathway signal sequence</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1081241</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ustYa family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041256.1">
        <property type="nucleotide sequence ID" value="XM_018173922.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CUL0"/>
    <dbReference type="STRING" id="1460663.A0A177CUL0"/>
    <dbReference type="GeneID" id="28757408"/>
    <dbReference type="InParanoid" id="A0A177CUL0"/>
    <dbReference type="OrthoDB" id="3687641at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021765">
        <property type="entry name" value="UstYa-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365:SF13">
        <property type="entry name" value="TAT PATHWAY SIGNAL SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365">
        <property type="entry name" value="YALI0B05434P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11807">
        <property type="entry name" value="UstYa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00035112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG10891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="229" mass="26819" checksum="7834A4AC0D546097" modified="2016-09-07" version="1">MWEKRVLLEATDEVCLEHTSKYSLLVKEVEPKWHDVRFNGTFLHENVYRQSAGPEVDAAWEALGVDYRPIVVPLEEAEKTGLRRDQVRVEDIHGGGFVANVEGLHHLHCLNILRKSLRWNYEYYLTEKKPPFSNSEDIVRIHVTHCLDILRQQLMCVPDIGVLGQVWYKLESMPQPMPFVDFNTEHRCRDFEGVRAWAERHQLPDEREVDLEHFYRMPGPGDTIYSAIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CV35</accession>
    <name>A0A177CV35_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_492550</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041095.1">
        <property type="nucleotide sequence ID" value="XM_018186509.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CV35"/>
    <dbReference type="GeneID" id="28769995"/>
    <dbReference type="InParanoid" id="A0A177CV35"/>
    <dbReference type="OrthoDB" id="3781946at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG10730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="191" mass="22682" checksum="1FBFD2C22C0B99C7" modified="2016-09-07" version="1">MTSYSLPNFSSRISKLEHFSQIAEPDSAPLHPDGSRHLLAVVYRDAPKIYPELKRYGDFSQGVRKIDISFDFISFYRFFKVTAGEFGKDCQPRCTLTYNVFERMPYLNEIIVRLPSDRMKTWVNKTHQMERPLFHITSPCPRMIYRILYERIAEALATYENVSVRNFLSETEEKRFWRKIKLFDAPETVQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CW68</accession>
    <name>A0A177CW68_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nucleoside-diphosphate-sugar epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1225325</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG11804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042169.1">
        <property type="nucleotide sequence ID" value="XM_018183564.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CW68"/>
    <dbReference type="STRING" id="1460663.A0A177CW68"/>
    <dbReference type="GeneID" id="28767050"/>
    <dbReference type="InParanoid" id="A0A177CW68"/>
    <dbReference type="OrthoDB" id="2130169at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051783">
        <property type="entry name" value="NAD(P)-dependent_oxidoreduct"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48079:SF6">
        <property type="entry name" value="NAD(P)-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48079">
        <property type="entry name" value="PROTEIN YEEZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-binding" evidence="2">
        <location>
            <begin position="9"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="1">
        <location>
            <begin position="149"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG11804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="342" mass="36732" checksum="DB1AD411977BA4FF" modified="2016-09-07" version="1">MAPKIFLTGGTGYIGGSILHALVTAHPEYDITVLLRKTPEAFTSTYPNVKIVQGDYDSAETLAERAKQADVVVHNGDSDHEPSLNALISGLLAKPKKSHLLHLSGTGIVSDWASPQHLGTLNPKVYSDVDDIAAIAALPDHALHRNTEKILFKTAAEHGDKLEIAVMCPPDIYGPGTGPGNTQSVFTRLFIADATTVAGNRVFYHGAGTNTRSWVHISDLTSLYLRVVEAAVADSPTFSGPGKYPGYYFAGTQEHAHIDVARTIGATLVKHGVIQDAEPVEVGLEEVDRMAKHPLFPKLGRYLYASNSRTRAVRAEKMFGYVGRAEGLLESIEGDVLAALGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CWJ8</accession>
    <name>A0A177CWJ8_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">25S rRNA (Uridine(2843)-N(3))-methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1078120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG11581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041946.1">
        <property type="nucleotide sequence ID" value="XM_018173787.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CWJ8"/>
    <dbReference type="FunCoup" id="A0A177CWJ8">
        <property type="interactions" value="34"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CWJ8"/>
    <dbReference type="GeneID" id="28757273"/>
    <dbReference type="InParanoid" id="A0A177CWJ8"/>
    <dbReference type="OrthoDB" id="6419443at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021463">
        <property type="entry name" value="Methyltransf_34"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11312">
        <property type="entry name" value="Methyltransf_34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG11581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="390" mass="43132" checksum="43E4FF45C975E34F" modified="2016-09-07" version="1">MGQFDRKAQSQPKHGKPSDSGASRAPPPPPKSRPLERGPGLKKKAPPKKPQPPKNGVPNLQPNILPVELQQLILDIFRATFPFEDFADLKPMLGKINEALVQGDFEEALRTEEFREGYAIRWSPTRALIFANVFEQICDEHRNSPWVERLLGGDGDGPAKALCFGGGAAEVMAMAGAMRYRRADAAGKPTPYLDLHLLDAADWSGVVSKLTTGLETPPELSKYASAAARARNASFLSPQALKVTCTQTRVLDLTQEELQSLFPPDVTLVTLLFTLNDLYTTSIRRATSFLRKLTAVVPTGCLLLVADAHGASSTADGKENGQEEPYPMSWLLDKVMLPTQLKVEDELMPKREWEKLMGDMNRLFKFPEKGLSYPAGLENLKMQVHLFKRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CWY3</accession>
    <name>A0A177CWY3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 20">DNA topoisomerase 2</fullName>
            <ecNumber evidence="7 20">5.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">CC84DRAFT_1201142</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24 25">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18 20">Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 19 20">
            <text>ATP-dependent breakage, passage and rejoining of double-stranded DNA.</text>
            <dbReference type="EC" id="5.6.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="6 20">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 20">Belongs to the type II topoisomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.2" evidence="7 20"/>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042398.1">
        <property type="nucleotide sequence ID" value="XM_018181706.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A177CWY3">
        <property type="interactions" value="1158"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CWY3"/>
    <dbReference type="GeneID" id="28765192"/>
    <dbReference type="InParanoid" id="A0A177CWY3"/>
    <dbReference type="OrthoDB" id="276498at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034506">
        <property type="term" value="C:chromosome, centromeric core domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000791">
        <property type="term" value="C:euchromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003918">
        <property type="term" value="F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007076">
        <property type="term" value="P:mitotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd16930">
        <property type="entry name" value="HATPase_TopII-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00187">
        <property type="entry name" value="TOP4c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03481">
        <property type="entry name" value="TopoIIA_Trans_ScTopoIIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03365">
        <property type="entry name" value="TOPRIM_TopoIIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.268.10:FF:000003">
        <property type="entry name" value="DNA topoisomerase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1360.40:FF:000003">
        <property type="entry name" value="DNA topoisomerase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.30:FF:000001">
        <property type="entry name" value="DNA topoisomerase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000008">
        <property type="entry name" value="DNA topoisomerase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000004">
        <property type="entry name" value="DNA topoisomerase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.670:FF:000001">
        <property type="entry name" value="DNA topoisomerase 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.199.10:FF:000002">
        <property type="entry name" value="DNA topoisomerase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.670">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.199.10">
        <property type="entry name" value="Topoisomerase II, domain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.268.10">
        <property type="entry name" value="Topoisomerase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050634">
        <property type="entry name" value="DNA_Topoisomerase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001241">
        <property type="entry name" value="Topo_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013760">
        <property type="entry name" value="Topo_IIA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013758">
        <property type="entry name" value="Topo_IIA_A/C_ab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013757">
        <property type="entry name" value="Topo_IIA_A_a_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013759">
        <property type="entry name" value="Topo_IIA_B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013506">
        <property type="entry name" value="Topo_IIA_bsu_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002205">
        <property type="entry name" value="Topo_IIA_dom_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001154">
        <property type="entry name" value="TopoII_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031660">
        <property type="entry name" value="TOPRIM_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034157">
        <property type="entry name" value="TOPRIM_TopoII"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10169:SF38">
        <property type="entry name" value="DNA TOPOISOMERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10169">
        <property type="entry name" value="DNA TOPOISOMERASE/GYRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00204">
        <property type="entry name" value="DNA_gyraseB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00521">
        <property type="entry name" value="DNA_topoisoIV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01751">
        <property type="entry name" value="Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16898">
        <property type="entry name" value="TOPRIM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01158">
        <property type="entry name" value="TOPISMRASEII"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00418">
        <property type="entry name" value="TPI2FAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00433">
        <property type="entry name" value="TOP2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00434">
        <property type="entry name" value="TOP4c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56719">
        <property type="entry name" value="Type II DNA topoisomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52040">
        <property type="entry name" value="TOPO_IIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 20" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15 19 20" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="16 19 20" id="KW-0413">Isomerase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 20" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14 19 20" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="Toprim" evidence="22">
        <location>
            <begin position="574"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="domain" description="Topo IIA-type catalytic" evidence="23">
        <location>
            <begin position="825"/>
            <end position="1275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="1203"/>
            <end position="1224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="1294"/>
            <end position="1438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="1464"/>
            <end position="1490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="1502"/>
            <end position="1545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="1625"/>
            <end position="1716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="21">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="21">
        <location>
            <begin position="15"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="21">
        <location>
            <begin position="60"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="21">
        <location>
            <begin position="1208"/>
            <end position="1220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="21">
        <location>
            <begin position="1353"/>
            <end position="1364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="21">
        <location>
            <begin position="1367"/>
            <end position="1377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="21">
        <location>
            <begin position="1401"/>
            <end position="1414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="21">
        <location>
            <begin position="1511"/>
            <end position="1525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="21">
        <location>
            <begin position="1643"/>
            <end position="1656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="21">
        <location>
            <begin position="1697"/>
            <end position="1716"/>
        </location>
    </feature>
    <feature type="active site" description="O-(5'-phospho-DNA)-tyrosine intermediate" evidence="19">
        <location>
            <position position="915"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00019635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00053943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU362094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS52040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="OAG12033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="1716" mass="190398" checksum="B8E838265082F42D" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CX78</accession>
    <name>A0A177CX78_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1070755</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042539.1">
        <property type="nucleotide sequence ID" value="XM_018173668.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CX78"/>
    <dbReference type="STRING" id="1460663.A0A177CX78"/>
    <dbReference type="GeneID" id="28757154"/>
    <dbReference type="InParanoid" id="A0A177CX78"/>
    <dbReference type="OrthoDB" id="4161595at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG12174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="234" mass="25989" checksum="1311BF3FFB4137E5" modified="2016-09-07" version="1" fragment="single">ESSDVEMKTEDNAGGSAPAPGEFRCMNDEFEVCRTGQTTVDLSRKVISDHFGRNKACTRLITDWPLFCRKHYQRATYNQKLWQSRKITLILRQFNIIEAQFSGTMYTVALKKSEEQRLNTFSRKLAAGKTELEAAALVAPAEKAKHFEAPVNVLREIEQLNYLGENKTKAEVEAAINTISDMLESGDTSQVPSIEFLPQLDASGNPYDTDDCGKATKKSSARVSKKGAVTKPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CY37</accession>
    <name>A0A177CY37_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1170496</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG11619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041984.1">
        <property type="nucleotide sequence ID" value="XM_018179859.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CY37"/>
    <dbReference type="GeneID" id="28763345"/>
    <dbReference type="InParanoid" id="A0A177CY37"/>
    <dbReference type="OrthoDB" id="4133832at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG11619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="391" mass="45247" checksum="2F7E0BB403FF1B6A" modified="2016-09-07" version="1">MPRRKTPDPNLNHDSSVADLLSKSLAAMRLAEDKAREVQWRVMLEDRRKKQAELAMQKEAATKRQTHAEEMEKRGNVYHDQKQLALKTLGPFMALPAEVRNNVYLFCQEPKPLALKPRTSDSSYNKIGKYFALTQVNRQIRAEFMHMHREHIDRATMDPWDVVHFVNTFFPSEEMGDERPNAAINVHIAINLDPIMGSVYDHTQIPTLDLKPLLELTTNEPGFRFSFVYLRVPKRKNRDISIGSDDGSHRKHVVKEQLRRLFDASREQGPSSAWAFFLAHFRQCELNHTADGTSSLEFVADKQITMSNVALWLDAWGFKWDSASLSPLKAMKTLWERVGIRVTIRFATDRRDQEPTKLRATEPVPFIQWDAVLHDLYYRPRKRVHASADSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CYI9</accession>
    <name>A0A177CYI9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Protein farnesyltransferase subunit beta</fullName>
            <shortName evidence="9">FTase-beta</shortName>
            <ecNumber evidence="2 9">2.5.1.58</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CC84DRAFT_1159665</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins. The beta subunit is responsible for peptide-binding.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-cysteinyl-[protein] + (2E,6E)-farnesyl diphosphate = S-(2E,6E)-farnesyl-L-cysteinyl-[protein] + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13345"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11535"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:86019"/>
            <dbReference type="ChEBI" id="CHEBI:175763"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Heterodimer of an alpha and a beta subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the protein prenyltransferase subunit beta family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.58" evidence="2 9"/>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042691.1">
        <property type="nucleotide sequence ID" value="XM_018177292.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CYI9"/>
    <dbReference type="FunCoup" id="A0A177CYI9">
        <property type="interactions" value="713"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CYI9"/>
    <dbReference type="GeneID" id="28760778"/>
    <dbReference type="InParanoid" id="A0A177CYI9"/>
    <dbReference type="OrthoDB" id="10261146at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005965">
        <property type="term" value="C:protein farnesyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004660">
        <property type="term" value="F:protein farnesyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097354">
        <property type="term" value="P:prenylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02893">
        <property type="entry name" value="FTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.20:FF:000014">
        <property type="entry name" value="Protein farnesyltransferase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026872">
        <property type="entry name" value="FTB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045089">
        <property type="entry name" value="PGGT1B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001330">
        <property type="entry name" value="Prenyltrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11774">
        <property type="entry name" value="GERANYLGERANYL TRANSFERASE TYPE BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11774:SF6">
        <property type="entry name" value="PROTEIN FARNESYLTRANSFERASE SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00432">
        <property type="entry name" value="Prenyltrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="Terpenoid cyclases/Protein prenyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 9" id="KW-0637">Prenyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 9 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Prenyltransferase alpha-alpha toroid" evidence="10">
        <location>
            <begin position="99"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OAG12326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="482" mass="53031" checksum="AA42CDF8C07E5C84" modified="2016-09-07" version="1">MASSRPEPSDALPPSVRLEEVLDDRLRIQELPDSDHEYEDLSPQEEAHMAYLESVRIPIVDSFKTDSSEVQDETLEAVLPFLEGNPNDFPLNEHGIPHLQKEKHIKFLKKALGDYPAPFAMMDASRPWLVYWSLQGLSSLGYDISEYRERVIHTFSLAQYPAGGYGGNYGHLPHLAATYAAVLSIIMVSTPSHPATYDSINRKNLWHFLGQLKQPDGGFNMTTGGEEDIRGAYCALIVLSLLQLPLELPDDAPARKHGLTSFTDRLGEWIGKCQAFDGGISAAPGNEAHGAYAFCGLGALAILGPPKQTLHKYLDMSRLIHWLSARQCAPEGGYNGRTNKLVDGCYSHWVGGCWAIVEGAAPASQHQSEGLWNRDALARYVLSAAQFVKGGLVDKPGKRPDAYHTCYNLAGLSAAQHRYMHDTETVEKGGLDAAFHWMANGTFAGSKIWTPADEVAYIHPIFVIPFSAASESRKYFADKGGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CYU1</accession>
    <name>A0A177CYU1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_157573</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018043090.1">
        <property type="nucleotide sequence ID" value="XM_018185407.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CYU1"/>
    <dbReference type="GeneID" id="28768893"/>
    <dbReference type="InParanoid" id="A0A177CYU1"/>
    <dbReference type="OrthoDB" id="10340926at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG12725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="150" mass="16981" checksum="34C55487AB4F928E" modified="2016-09-07" version="1">MSILSKLKFQPCLIVLIPFQPIVVRASWTMLTLQRIGTILSSATTTLAFLMKHLRCNGRTDCALRPALVYNRTYKPVGVREWGCLLITHLLIAITSHTFSTSYVGMKLTVASGMPNSLFRVVLHLFMMILRYSHCVSGFCRFDLTKKNLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CZR7</accession>
    <name>A0A177CZR7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1201367</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042705.1">
        <property type="nucleotide sequence ID" value="XM_018181717.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CZR7"/>
    <dbReference type="GeneID" id="28765203"/>
    <dbReference type="InParanoid" id="A0A177CZR7"/>
    <dbReference type="OrthoDB" id="10547281at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="281"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="284"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG12340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="346" mass="39340" checksum="57AFCA290284FC2D" modified="2016-09-07" version="1">MQATASRNWPQRAKLPITVSTRPPPERCILSQATGQPLPINPLYASALRNSLRQLSLRPPEVRVPRPIRGRTKKISKAKSRGSHQDKARRYCPSPLRREVLAEEVEVKSSSIPVPKPVGLPAPSPKILKRLIKLNLFRTKEDSAPIYTPGNMPRMFLASSGRTQIQFQPRIYHCQFARLQRAAIPERGRLLRRSLALNQKQQLHVTRRALRQTSSIVLEELGQKRDAIDTAWCKRCKHCLKHERKRILKAAKQELKRTLKAIDDSRKEEEQQFDHLYRIAKQRSQGEDGEHGSVEGGDGTVKKVLGLHSGSRRINGFSKRVLVLRGADLFKEASCKRGHEAEDVED</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177D099</accession>
    <name>A0A177D099_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_180586</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG13125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018043490.1">
        <property type="nucleotide sequence ID" value="XM_018185485.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177D099"/>
    <dbReference type="STRING" id="1460663.A0A177D099"/>
    <dbReference type="GeneID" id="28768971"/>
    <dbReference type="InParanoid" id="A0A177D099"/>
    <dbReference type="OrthoDB" id="5419922at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="277"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="645"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="117"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="365"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="394"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="418"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="457"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="527"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="648"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="679"/>
            <end position="703"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG13125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="742" mass="81119" checksum="7D2BCC5C817ABDE0" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177D0B2</accession>
    <name>A0A177D0B2_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="10">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CC84DRAFT_1212370</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="10">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="10"/>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018043246.1">
        <property type="nucleotide sequence ID" value="XM_018182446.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177D0B2"/>
    <dbReference type="FunCoup" id="A0A177D0B2">
        <property type="interactions" value="1025"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177D0B2"/>
    <dbReference type="GeneID" id="28765932"/>
    <dbReference type="InParanoid" id="A0A177D0B2"/>
    <dbReference type="OrthoDB" id="10259640at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17941">
        <property type="entry name" value="DEADc_DDX10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025313">
        <property type="entry name" value="SPB4-like_CTE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13959">
        <property type="entry name" value="CTE_SPB4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01178">
        <property type="entry name" value="DUF4217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 10" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="8 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="12">
        <location>
            <begin position="82"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="13">
        <location>
            <begin position="284"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="500"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="559"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="668"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="703"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="559"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="672"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="704"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="727"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="752"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="784"/>
            <end position="793"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OAG12881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="814" mass="90928" checksum="EB3B85D059B2D697" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177D176</accession>
    <name>A0A177D176_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_165842</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018043287.1">
        <property type="nucleotide sequence ID" value="XM_018185441.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177D176"/>
    <dbReference type="GeneID" id="28768927"/>
    <dbReference type="InParanoid" id="A0A177D176"/>
    <dbReference type="OrthoDB" id="10569772at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG12922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="145" mass="15244" checksum="57503C08B0BF80A9" modified="2016-09-07" version="1">MLASCLLAVPDGATAFAFSLSLFSSSLSTSVLMMSLHHHIIFLSSYRLTSPSVAIWVVKIKARVFGELAFGCVGAPGASVAQLERRQLAEHAPDSSTHSFRACHAKRTRGFQSSRSEGHATHLKGSGTTRASGEGGTRNGALSQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177D1N1</accession>
    <name>A0A177D1N1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_166284</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018043304.1">
        <property type="nucleotide sequence ID" value="XM_018185445.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177D1N1"/>
    <dbReference type="STRING" id="1460663.A0A177D1N1"/>
    <dbReference type="GeneID" id="28768931"/>
    <dbReference type="InParanoid" id="A0A177D1N1"/>
    <dbReference type="OrthoDB" id="3799720at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008058877" evidence="1">
        <location>
            <begin position="21"/>
            <end position="652"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG12939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="652" mass="62815" checksum="96BC3FFF17AD91F0" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BTA9</accession>
    <name>A0A177BTA9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">DUF159-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CC84DRAFT_1170007</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SOS response-associated peptidase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441565">
        <property type="protein sequence ID" value="OAF98642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029008.1">
        <property type="nucleotide sequence ID" value="XM_018179809.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BTA9"/>
    <dbReference type="FunCoup" id="A0A177BTA9">
        <property type="interactions" value="605"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177BTA9"/>
    <dbReference type="GeneID" id="28763295"/>
    <dbReference type="InParanoid" id="A0A177BTA9"/>
    <dbReference type="OrthoDB" id="2111841at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106300">
        <property type="term" value="P:protein-DNA covalent cross-linking repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1680.10">
        <property type="entry name" value="SOS response associated peptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003738">
        <property type="entry name" value="SRAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036590">
        <property type="entry name" value="SRAP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13604:SF0">
        <property type="entry name" value="ABASIC SITE PROCESSING PROTEIN HMCES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13604">
        <property type="entry name" value="DC12-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02586">
        <property type="entry name" value="SRAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143081">
        <property type="entry name" value="BB1717-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0190">Covalent protein-DNA linkage</keyword>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="316"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="316"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="351"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="392"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="403"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAF98642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="427" mass="47448" checksum="2BE863703E620A40" modified="2016-09-07" version="1">MCGRYALALRPSVVRQQLEQSQMPVDSAPDDNDVRQSYNFAPGYCGLVYRADGPDSGTSTLQNQHDELGTQNNITSVPAAGHMDGTKYKLQAMKWGLVPFWTKRNPDYGSMLKTINCRDDSLYDDRGMWTSMKKKKRCIVVAQGFYEWLKKNNGKEKIPHFTKRKDGQLMCFAGLYDCVQFDDSEKLLYTYTIITTDSNKQLKFLHDRMPVILDNGSKAVKTWLDPERKEWSTDLQSLLQPYDGELECFPVSGEVGKVGNNSPQFVVPVNSAANKSNIANFFGNQQKMAKAKKDEGIVGRAEHDDGKTTDQIAIKVEQDANEPRETTNQVQGSEDNAPLPVPAPIFPSRGEGLKGIKRERSEAEDDGDTASGARQQKRRMPGPGSSQSPQKRGTKAPAKKTRSATSNGSAAKASPSNQKRIESFFAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BTD0</accession>
    <name>A0A177BTD0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1182056</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441565">
        <property type="protein sequence ID" value="OAF98662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029028.1">
        <property type="nucleotide sequence ID" value="XM_018180595.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BTD0"/>
    <dbReference type="GeneID" id="28764081"/>
    <dbReference type="InParanoid" id="A0A177BTD0"/>
    <dbReference type="OrthoDB" id="366390at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAF98662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="440" mass="49855" checksum="BA835A898B80CC78" modified="2016-09-07" version="1">MGLLDLPPEIFQRIIQKHVAATGLCSAWKGRGVCETFNTYITEEVFARQPVKVYSKRRINGLYRRGLAVFLEYRLNTLHGAHDLIPSVIRNVVDKLMQITRLTSAEARSELNRDVIAAIVRLWKKADVAAVKPTKRMEKGCSKDSEEARLLCLVVSMGNLDLTKAVLQHCTDPWSETYCLGSPIEVAISAMDLEHVELLLADTKSRKSTRASIFARFLDKFFDAPVGDSQLEFVDQLLSLHYTFLGRPLSDYRVRWLGNFHMRGPTGEGVVTKILEMGFTSKLAALYRQRLFEWWGERFDRTTMKLFVTHKVFDMTQKYAFDDRYGDSAYSMQDESVLAYAVRVGDVDLVEVALKAGANANGAVNPNGFCEYPISSALQNTRCKAKILELLLDHGADLYGDHSVFHYCDIKTMYLGGDYEKRKILDAAIERANYSYKGYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BTX9</accession>
    <name>A0A177BTX9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Eukaryotic translation initiation factor 2 subunit gamma</fullName>
            <ecNumber evidence="2">3.6.5.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CC84DRAFT_1132135</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.3" evidence="2"/>
    <dbReference type="EMBL" id="KV441564">
        <property type="protein sequence ID" value="OAF98714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029080.1">
        <property type="nucleotide sequence ID" value="XM_018175927.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BTX9"/>
    <dbReference type="FunCoup" id="A0A177BTX9">
        <property type="interactions" value="1093"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177BTX9"/>
    <dbReference type="GeneID" id="28759413"/>
    <dbReference type="InParanoid" id="A0A177BTX9"/>
    <dbReference type="OrthoDB" id="1045173at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005850">
        <property type="term" value="C:eukaryotic translation initiation factor 2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043614">
        <property type="term" value="C:multi-eIF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990856">
        <property type="term" value="F:methionyl-initiator methionine tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001731">
        <property type="term" value="P:formation of translation preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045903">
        <property type="term" value="P:positive regulation of translational fidelity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01888">
        <property type="entry name" value="eIF2_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03688">
        <property type="entry name" value="eIF2_gamma_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15490">
        <property type="entry name" value="eIF2_gamma_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000009">
        <property type="entry name" value="Eukaryotic translation initiation factor 2 subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000011">
        <property type="entry name" value="Eukaryotic translation initiation factor 2 subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000065">
        <property type="entry name" value="Eukaryotic translation initiation factor 2 subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050543">
        <property type="entry name" value="eIF2G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015256">
        <property type="entry name" value="eIF2g_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044127">
        <property type="entry name" value="eIF2g_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044128">
        <property type="entry name" value="eIF2g_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003077">
        <property type="entry name" value="PRK04000.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42854">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 3 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42854:SF3">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09173">
        <property type="entry name" value="eIF2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 12" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="11">
        <location>
            <begin position="70"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00074422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OAF98714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="500" mass="54640" checksum="81B299157BFB3159" modified="2016-09-07" version="1">MDSESEHDHRDDESLSEPEEVEETKPRPALKKPRDVLPPVERPELPEQPEPSTVDFSTLSPLSPEIISRQATINIGTIGHVAHGKSTVVKAISGVQTVRFKNELERNITIKLGYANAKIYQCDNPECPRPTCYRSYKSEKEVDPPCEREGCGGKYRLKRHVSFVDCPGHDILMSTMLSGAAVMDAALLLIAGNETCPQPQTSEHLAAIEIMKLNHIIILQNKVDLMREDNAAAHYDSILKFIRGTVADGSPIIPISAQLKFNIDAINEQLITKIPVPVRDFSAKPHMIVIRSFDVNKPGAEIDELKGGVAGGSILTGVLKLGDEIEIRPGIVSKDSAGKIQCKPIFSRVVSLFAEHNDLKFAVPGGLIGVGTRVDPTLCRADRLVGFVLGLRGHLPNIYTEIEVNYFLLRRLLGVKTADGKQAKVAKLAKNEVLMVNIGSTATGAKVIAVRADAARLSLTSPACTEIGEKVALSRRIEKHWRLIGWANIVAGNILEPLKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BTY3</accession>
    <name>A0A177BTY3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Collagen-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1264459</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441563">
        <property type="protein sequence ID" value="OAF98873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029239.1">
        <property type="nucleotide sequence ID" value="XM_018185311.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BTY3"/>
    <dbReference type="STRING" id="1460663.A0A177BTY3"/>
    <dbReference type="GeneID" id="28768797"/>
    <dbReference type="InParanoid" id="A0A177BTY3"/>
    <dbReference type="OrthoDB" id="10678633at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030020">
        <property type="term" value="F:extracellular matrix structural constituent conferring tensile strength"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030198">
        <property type="term" value="P:extracellular matrix organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050149">
        <property type="entry name" value="Collagen_superfamily"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24023:SF1112">
        <property type="entry name" value="COL_CUTICLE_N DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24023">
        <property type="entry name" value="COLLAGEN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008057310" description="Collagen-like protein" evidence="2">
        <location>
            <begin position="23"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="148"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="194"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="231"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="255"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="267"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="282"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="311"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="360"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="387"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAF98873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="413" mass="38858" checksum="B1FCA0A3B4061281" modified="2016-09-07" version="1">MKAILFRAVAVQTLFLNNPILAFPVGVSLATDLPTALLEPETHRTIANVTKEFYVGLTVPIYKLLTPRRIAPRQVPEVTPAVLPEVTPPVVPEVTPPVVPEVTPPVLPEVTPPVVPEVTPPVVPEVTSPVAPEVTPPVAPEVTPPVAPEVTSPVAPEVTPSAPEPDVPSENDNWSIPGPPGPPGPPGPPGPQGPFGLEGFPGSEGPPGPAGSPGPQADPGPPGPPGPAGVPGPAGVNGPVGVSGRPGSPGPSGPPGATGLAGASGPPGRPAPPGPPGPAGPPGLNGLDGPPGSTGPAGAKGLNGSPGLPGPAGSAGSAGLPGPSGPAGPAGMSGPAGSPGSAGLSGPPGRNGLNGSPGVPGAPGPPGPSGAPGTPGRNGLNGSPGLAGPPGPPGPPGPPGPPGPPGPRASPVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BUC0</accession>
    <name>A0A177BUC0_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">phosphoinositide 5-phosphatase</fullName>
            <ecNumber evidence="4">3.1.3.36</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CC84DRAFT_422445</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the synaptojanin family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the central section; belongs to the inositol 1,4,5-trisphosphate 5-phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.36" evidence="4"/>
    <dbReference type="EMBL" id="KV441564">
        <property type="protein sequence ID" value="OAF98735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029101.1">
        <property type="nucleotide sequence ID" value="XM_018186165.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BUC0"/>
    <dbReference type="FunCoup" id="A0A177BUC0">
        <property type="interactions" value="361"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177BUC0"/>
    <dbReference type="GeneID" id="28769651"/>
    <dbReference type="InParanoid" id="A0A177BUC0"/>
    <dbReference type="OrthoDB" id="405996at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043813">
        <property type="term" value="F:phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004439">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.10.10:FF:000029">
        <property type="entry name" value="Inositol polyphosphate 5-phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046985">
        <property type="entry name" value="IP5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000300">
        <property type="entry name" value="IPPc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002013">
        <property type="entry name" value="SAC_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200">
        <property type="entry name" value="INOSITOL 5-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200:SF257">
        <property type="entry name" value="PHOSPHOINOSITIDE 5-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22669">
        <property type="entry name" value="Exo_endo_phos2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02383">
        <property type="entry name" value="Syja_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00128">
        <property type="entry name" value="IPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50275">
        <property type="entry name" value="SAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="SAC" evidence="10">
        <location>
            <begin position="167"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="941"/>
            <end position="1040"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1104"/>
            <end position="1246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OAF98735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="1246" mass="138210" checksum="EB955C5EB6374528" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BUJ2</accession>
    <name>A0A177BUJ2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_410980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441563">
        <property type="protein sequence ID" value="OAF98954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029320.1">
        <property type="nucleotide sequence ID" value="XM_018186100.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BUJ2"/>
    <dbReference type="GeneID" id="28769586"/>
    <dbReference type="InParanoid" id="A0A177BUJ2"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAF98954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="192" mass="20559" checksum="EA9A1197916C26A9" modified="2016-09-07" version="1">MRAGAGLEGCNEWLSSGVVCPSHGQKGRRHRKTRRRKQKSAGGRAGIGRRVWGAQRAQSRSFELLGHSRGPARKHIPGQNRCNLEEEGSGGHVAAAPSNGWALAGVPCMQRPYLGGRTRDEWPTAGGRGLEGAEGLDVCTTRRDGQQSGGHWSFGGALSKTWAESDPQGHGGGQLMQLTRPGRCACTWEIVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BVR9</accession>
    <name>A0A177BVR9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1182045</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441565">
        <property type="protein sequence ID" value="OAF98647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029013.1">
        <property type="nucleotide sequence ID" value="XM_018180593.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BVR9"/>
    <dbReference type="GeneID" id="28764079"/>
    <dbReference type="InParanoid" id="A0A177BVR9"/>
    <dbReference type="OrthoDB" id="10248475at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004089">
        <property type="term" value="F:carbonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1050.10">
        <property type="entry name" value="Carbonic anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036874">
        <property type="entry name" value="Carbonic_anhydrase_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53056">
        <property type="entry name" value="beta-carbonic anhydrase, cab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAF98647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="153" mass="16647" checksum="3924432009AAB2E7" modified="2016-09-07" version="1">MPSGTLVIIHMCTRSVTDKAVACSEPETRVEPSKYFNLTASGNTRVIKTAGGRAGNCINELHTIDQASSIGMIVVLQHSECVWAPGDIEANVRSDIGTLKNSPYVRKGIPIIGYALNAATGQLKEVNIRRSTQDEAARQQVLQEFQDFAPFWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BW89</accession>
    <name>A0A177BW89_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 9">Uracil-DNA glycosylase</fullName>
            <shortName evidence="7">UDG</shortName>
            <ecNumber evidence="7 9">3.2.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">UNG1</name>
        <name evidence="12" type="ORF">CC84DRAFT_1169204</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 9">Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 9">
            <text>Hydrolyzes single-stranded DNA or mismatched double-stranded DNA and polynucleotides, releasing free uracil.</text>
            <dbReference type="EC" id="3.2.2.27"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 9">Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.27" evidence="7 9"/>
    <dbReference type="EMBL" id="KV441561">
        <property type="protein sequence ID" value="OAF99682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030048.1">
        <property type="nucleotide sequence ID" value="XM_018179595.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BW89"/>
    <dbReference type="FunCoup" id="A0A177BW89">
        <property type="interactions" value="302"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177BW89"/>
    <dbReference type="GeneID" id="28763081"/>
    <dbReference type="InParanoid" id="A0A177BW89"/>
    <dbReference type="OrthoDB" id="10031947at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004844">
        <property type="term" value="F:uracil DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097510">
        <property type="term" value="P:base-excision repair, AP site formation via deaminated base removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10027">
        <property type="entry name" value="UDG-F1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.470.10:FF:000007">
        <property type="entry name" value="Uracil-DNA glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.470.10">
        <property type="entry name" value="Uracil-DNA glycosylase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00148">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002043">
        <property type="entry name" value="UDG_fam1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018085">
        <property type="entry name" value="Ura-DNA_Glyclase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005122">
        <property type="entry name" value="Uracil-DNA_glycosylase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036895">
        <property type="entry name" value="Uracil-DNA_glycosylase-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003588">
        <property type="entry name" value="PRK05254.1-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003589">
        <property type="entry name" value="PRK05254.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003592">
        <property type="entry name" value="PRK05254.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00628">
        <property type="entry name" value="ung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11264">
        <property type="entry name" value="URACIL-DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11264:SF0">
        <property type="entry name" value="URACIL-DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03167">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00986">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00987">
        <property type="entry name" value="UreE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52141">
        <property type="entry name" value="Uracil-DNA glycosylase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00130">
        <property type="entry name" value="U_DNA_GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7 9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5 7 9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 7 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Uracil-DNA glycosylase-like" evidence="11">
        <location>
            <begin position="113"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7 8">
        <location>
            <position position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OAF99682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="303" mass="33646" checksum="1FA3FCFF1A9E2EAB" modified="2016-09-07" version="1">MSLKRKAASAATDAAKKPKVNGSITSFFGAPKPKEGATAAAKFDKDAWVAKLTDEQKELLKLEIDTLHESWLPHVKDVLLSPTFLDLKRFLKKELASGKAVYPPMKDVYSWSRHTPLNTVKAVITGQDPYHNPNQAHGLCFSVRPPTPAPPSLKNIYIALKKDYPDFKEPPNRGGLLTPWADHGVLMLNTCLTVEKNKANSHSGKGWELLTQKVIDTVAKVRTNGVVFLAWGSPAQQRVKDIEKAYKERHLILRSVHPSPLAAHKGFFDCGHFKKANDWLEVKYGKGEGIDWNLDVDPKEAGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BWF8</accession>
    <name>A0A177BWF8_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein arginine methyltransferase NDUFAF7</fullName>
            <ecNumber evidence="7">2.1.1.320</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CC84DRAFT_1105140</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Arginine methyltransferase involved in the assembly or stability of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>L-arginyl-[protein] + 2 S-adenosyl-L-methionine = N(omega),N(omega)'-dimethyl-L-arginyl-[protein] + 2 S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:48108"/>
            <dbReference type="Rhea" id="RHEA-COMP:10532"/>
            <dbReference type="Rhea" id="RHEA-COMP:11992"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29965"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:88221"/>
            <dbReference type="EC" id="2.1.1.320"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the NDUFAF7 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.320" evidence="7"/>
    <dbReference type="EMBL" id="KV441563">
        <property type="protein sequence ID" value="OAF99081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029447.1">
        <property type="nucleotide sequence ID" value="XM_018175085.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BWF8"/>
    <dbReference type="FunCoup" id="A0A177BWF8">
        <property type="interactions" value="28"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177BWF8"/>
    <dbReference type="GeneID" id="28758571"/>
    <dbReference type="InParanoid" id="A0A177BWF8"/>
    <dbReference type="OrthoDB" id="17415at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035243">
        <property type="term" value="F:protein-arginine omega-N symmetric methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12710:FF:000002">
        <property type="entry name" value="Protein arginine methyltransferase NDUFAF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003788">
        <property type="entry name" value="NDUFAF7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038375">
        <property type="entry name" value="NDUFAF7_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12049:SF5">
        <property type="entry name" value="PROTEIN ARGININE METHYLTRANSFERASE NDUFAF7 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12049">
        <property type="entry name" value="PROTEIN ARGININE METHYLTRANSFERASE NDUFAF7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02636">
        <property type="entry name" value="Methyltransf_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5 7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="34"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="46"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="57"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAF99081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="505" mass="59140" checksum="7CBDE765B927D174" modified="2016-09-07" version="1">MDSPQVTQLFRQLFSHRASQCLVRGARPVLAQAARTPQIQHRGRATKAAPRTTTRLGEGETKRESRWQPRRNAFPHERTEEFERYPLVTSDMLRSRRERPRRVKMLLRDFIEDSLYNPHYGYFSKQVVIFSPGEPFDFPSLPSEHAFFQSLRHRYTAFEDALDFQEPNDLRQLWHTPTELFSPYYGEAIARYLVEDYKYSSYPYHDLNIYEMGAGNGTMMLNILDYIRDCHPEVYERTKYNIIEITTQLADLQQQGLGHSAYARGHSDKVEIVNKSVFDWDQYVSSPCYFLALEVFDNFAHDALKYDWQTGTPYQSHVVIDPRGEMFEYYSRALDPLAAQFLERRHAACKSYADPLSGSRLMNSMRSLLPFRDSLTMPEYIPTRLMQFFYMLYQKFPNHKLISSDFHKLSDGVEGLNAPVVQTRYKRQMIPVSTPLVHQGYFDILFPTDFEVIEPMYTAITGRFARTYSHEVFMSGRADIEETQTRNGENPLLSWYKNASVMITV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BWG9</accession>
    <name>A0A177BWG9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_416147</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441563">
        <property type="protein sequence ID" value="OAF99091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029457.1">
        <property type="nucleotide sequence ID" value="XM_018186133.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BWG9"/>
    <dbReference type="GeneID" id="28769619"/>
    <dbReference type="InParanoid" id="A0A177BWG9"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAF99091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="176" mass="20096" checksum="13D908DBBD69AD4E" modified="2016-09-07" version="1">MQVSLPLPLRHSKNTQEADHWPRKRHSPGTKFPEYVKLVDVKFTSIPASQRPHSYAFGSQPSTSTQHHINISLQVYVRRPVISWRPPTRRSHTHFTSSLPTASTRLRHRTLAPCLPPLVCQTASRHQRLAEQCRCSLIQLLQCCVYICFCGEVRPGVSAAEGKRRRAERSPVWGWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BWK1</accession>
    <name>A0A177BWK1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Major facilitator superfamily transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CC84DRAFT_1168780</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV441560">
        <property type="protein sequence ID" value="OAF99863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030229.1">
        <property type="nucleotide sequence ID" value="XM_018179486.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BWK1"/>
    <dbReference type="FunCoup" id="A0A177BWK1">
        <property type="interactions" value="28"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177BWK1"/>
    <dbReference type="GeneID" id="28762972"/>
    <dbReference type="InParanoid" id="A0A177BWK1"/>
    <dbReference type="OrthoDB" id="3561359at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140115">
        <property type="term" value="P:export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042908">
        <property type="term" value="P:xenobiotic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000082">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF7">
        <property type="entry name" value="DRUG_PROTON ANTIPORTER YHK8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="150"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="182"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="218"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="277"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="306"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="382"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="420"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="461"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="488"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="557"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="152"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="67"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAF99863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="592" mass="65413" checksum="787345A40C05B640" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BWK3</accession>
    <name>A0A177BWK3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DNA-directed RNA polymerase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CC84DRAFT_1169824</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">DNA-dependent RNA polymerase which catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441563">
        <property type="protein sequence ID" value="OAF99131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029497.1">
        <property type="nucleotide sequence ID" value="XM_018179764.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BWK3"/>
    <dbReference type="FunCoup" id="A0A177BWK3">
        <property type="interactions" value="735"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177BWK3"/>
    <dbReference type="GeneID" id="28763250"/>
    <dbReference type="InParanoid" id="A0A177BWK3"/>
    <dbReference type="OrthoDB" id="10256606at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006386">
        <property type="term" value="P:termination of RNA polymerase III transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006384">
        <property type="term" value="P:transcription initiation at RNA polymerase III promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042797">
        <property type="term" value="P:tRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd04330">
        <property type="entry name" value="RNAP_III_Rpc25_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.120:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000221">
        <property type="entry name" value="DNA-directed RNA polymerase III subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.120">
        <property type="entry name" value="RNA polymerase Rpb7-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013238">
        <property type="entry name" value="RNA_pol_III_Rbc25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036898">
        <property type="entry name" value="RNA_pol_Rpb7-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045113">
        <property type="entry name" value="Rpb7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005576">
        <property type="entry name" value="Rpb7-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II, III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709:SF1">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08292">
        <property type="entry name" value="RNA_pol_Rbc25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03876">
        <property type="entry name" value="SHS2_Rpb7-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88798">
        <property type="entry name" value="N-terminal, heterodimerisation domain of RBP7 (RpoE)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="S1 motif" evidence="8">
        <location>
            <begin position="82"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="199"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU369086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAF99131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="220" mass="25087" checksum="98EDE74D58B75073" modified="2016-09-07" version="1">MFILTTLEDLIQIAPQDFSKESAQAIKDAINIKYANKVIHKVGLCITMWDMLKASEGLIGHGTGLVNVNVEFRLVVFRPFRGEILHGRIKSANEQGMVIDLDFTHEVFVPQANLFEPSHYDPGENAWVWSPPDGEEFFFDKGETVLLRVEREEWFDQKPSIVQKDEHGNIVERRGVPWRIIASMNQSGLGPCMWWEGQEGEEEEGEQQLLESGDVEMNEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BXF3</accession>
    <name>A0A177BXF3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_1199813</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441561">
        <property type="protein sequence ID" value="OAF99640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030006.1">
        <property type="nucleotide sequence ID" value="XM_018181639.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BXF3"/>
    <dbReference type="STRING" id="1460663.A0A177BXF3"/>
    <dbReference type="GeneID" id="28765125"/>
    <dbReference type="InParanoid" id="A0A177BXF3"/>
    <dbReference type="OrthoDB" id="419598at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051609">
        <property type="entry name" value="NmrA/Isoflavone_reductase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706:SF11">
        <property type="entry name" value="ISOFLAVONE REDUCTASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_1G12510)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706">
        <property type="entry name" value="NMRA-LIKE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="6"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAF99640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="292" mass="32058" checksum="F1CE02EFA09CD8BF" modified="2016-09-07" version="1">MAPLPKKILVFGATGVIGKYIISGLVDAKASVEKIGIFTLPTTVENQDVEVLVGNVESEADVTRAYDGCDTVISALGRSTILVQTPLHRLAEASPTIHTFFPSEFGTDNEYSTSTSTHEKLHQLKLQVRKYVREYIRKVAVTYLVTGPYSDLYLSAQAGDFERAGSFDVKGGKAVLLGDGDSRVAFTSMRDVGVLLVAALKTSGEGSPRTLKVNSFTATPWQILVEFERQTGKVWCVEYTGDGTRYTLRRIWTERGTLHAERVNGIIGEPNLETLERQVRLSIERQLGKGQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BXJ6</accession>
    <name>A0A177BXJ6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Saccharopine dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_1264248</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the saccharopine dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441562">
        <property type="protein sequence ID" value="OAF99237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029603.1">
        <property type="nucleotide sequence ID" value="XM_018185297.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BXJ6"/>
    <dbReference type="GeneID" id="28768783"/>
    <dbReference type="InParanoid" id="A0A177BXJ6"/>
    <dbReference type="OrthoDB" id="10268090at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009247">
        <property type="term" value="P:glycolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051276">
        <property type="entry name" value="Saccharopine_DH-like_oxidrdct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005097">
        <property type="entry name" value="Sacchrp_dh_NADP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12286">
        <property type="entry name" value="SACCHAROPINE DEHYDROGENASE-LIKE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12286:SF5">
        <property type="entry name" value="SACCHAROPINE DEHYDROGENASE-LIKE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03435">
        <property type="entry name" value="Sacchrp_dh_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="293"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="Saccharopine dehydrogenase NADP binding" evidence="3">
        <location>
            <begin position="10"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAF99237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="428" mass="46692" checksum="A003221DF3EE49C2" modified="2016-09-07" version="1">MAQSRQYELVLFGATGYTGKLTAEWISQHLPIDLKWAIAGRNANKLQDVIEELKRLCPDRKQPDIETCELKEDQLTSLALKTRLIITTVGPFMFYGEPVLAACAKTGTHYLDCTGEVPWIHSMIPKYHDQAKSTGAIIIPECGLDSVPADILAYALTSHVRKTLNAGTANVNMSFFAGKSGFSGGTAHTILQLFENFGMKELGDAMKPWSLSPVQPTNPARSPKGSLLHRLFGLVNIPEIGGIQTTWLMASVDRCITHRSWGLYESSAKSTSTPSLSYGPRFNFNEYMRAKSLIAGLAVNVGMALFGLAFAFPLSRWILSPLVKRFVLPQPGEGPSRESMKKDFMDYKAVAIADTDRQEKVHGTLHIPHGGYVATAQTLSAAALVILRGRLENTEAGRLGGGILTPATLGQPFVEKLDEFGIKIEVGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BYC3</accession>
    <name>A0A177BYC3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_1130603</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441561">
        <property type="protein sequence ID" value="OAF99691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030057.1">
        <property type="nucleotide sequence ID" value="XM_018175865.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BYC3"/>
    <dbReference type="STRING" id="1460663.A0A177BYC3"/>
    <dbReference type="GeneID" id="28759351"/>
    <dbReference type="InParanoid" id="A0A177BYC3"/>
    <dbReference type="OrthoDB" id="5371740at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44229">
        <property type="entry name" value="15-HYDROXYPROSTAGLANDIN DEHYDROGENASE [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44229:SF4">
        <property type="entry name" value="15-HYDROXYPROSTAGLANDIN DEHYDROGENASE [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAF99691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="297" mass="32310" checksum="2AB28ED9997C17EC" modified="2016-09-07" version="1">MSKKVALITGGASGMGLEVATRLSKLSAWEIHILDLPGSPGSSVASSLGATFHPSDVTDEPGLNQIFKTVYSRNERLDFVFANAGIAEHANFFEEQDIDGDVKLPVKGLHALVDINLKSVITTSYLALQYMRHSRGTDKSLVITASCGGLYPSYYSPIYTATKHAVVGLTRSIAPYFHTRAGIRVNCICPGTVKTNLLTSAEWANFPEEYFTPVHKIGEVVLMLIDGKDNGKGEVGREVEEGSVEKLLEKGMYGRAVEVSGRRHYYREMVGYADEAMSAVMGATNIEVLEDAVERTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BYN4</accession>
    <name>A0A177BYN4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">MPN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CC84DRAFT_1156813</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M67C family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441561">
        <property type="protein sequence ID" value="OAF99741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030107.1">
        <property type="nucleotide sequence ID" value="XM_018176986.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BYN4"/>
    <dbReference type="STRING" id="1460663.A0A177BYN4"/>
    <dbReference type="GeneID" id="28760472"/>
    <dbReference type="InParanoid" id="A0A177BYN4"/>
    <dbReference type="OrthoDB" id="3640at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061578">
        <property type="term" value="F:K63-linked deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070530">
        <property type="term" value="F:K63-linked polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140492">
        <property type="term" value="F:metal-dependent deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120113">
        <property type="term" value="P:cytoplasm to vacuole targeting by the NVT pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070536">
        <property type="term" value="P:protein K63-linked deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd08066">
        <property type="entry name" value="MPN_AMSH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000033">
        <property type="entry name" value="AMSH-like protease sst2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.80">
        <property type="entry name" value="Phosphotransferase system, lactose/cellobiose-type IIA subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044098">
        <property type="entry name" value="STAMBP/STALP-like_MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015063">
        <property type="entry name" value="USP8_dimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12947">
        <property type="entry name" value="AMSH-LIKE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12947:SF13">
        <property type="entry name" value="FI19924P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08969">
        <property type="entry name" value="USP8_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102712">
        <property type="entry name" value="JAB1/MPN domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140856">
        <property type="entry name" value="USP8 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="MPN" evidence="10">
        <location>
            <begin position="368"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="170"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="231"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="170"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="232"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="247"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="283"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="302"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OAF99741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="545" mass="61117" checksum="A6F5ECFB6D0E8587" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BYU8</accession>
    <name>A0A177BYU8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cysteine proteinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CC84DRAFT_1221848</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C48 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441559">
        <property type="protein sequence ID" value="OAG00326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030691.1">
        <property type="nucleotide sequence ID" value="XM_018183309.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BYU8"/>
    <dbReference type="STRING" id="1460663.A0A177BYU8"/>
    <dbReference type="GeneID" id="28766795"/>
    <dbReference type="InParanoid" id="A0A177BYU8"/>
    <dbReference type="OrthoDB" id="5065855at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019784">
        <property type="term" value="F:deNEDDylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000338">
        <property type="term" value="P:protein deneddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.395.10">
        <property type="entry name" value="Adenoviral Proteinase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044613">
        <property type="entry name" value="Nep1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003653">
        <property type="entry name" value="Peptidase_C48_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46468">
        <property type="entry name" value="SENTRIN-SPECIFIC PROTEASE 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46468:SF1">
        <property type="entry name" value="SENTRIN-SPECIFIC PROTEASE 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02902">
        <property type="entry name" value="Peptidase_C48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50600">
        <property type="entry name" value="ULP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0788">Thiol protease</keyword>
    <feature type="domain" description="Ubiquitin-like protease family profile" evidence="6">
        <location>
            <begin position="17"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="242"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="245"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAG00326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="270" mass="30659" checksum="E643580741F159D3" modified="2016-09-07" version="1">MKNWAGDDTVYFAYHDSNVTRHDMSTLADEHGWLEDNVINFWIQYIENEEMHNFPKARIELFAPSMSTFMKLEQDPSVAKSVLAQMPDLAANKTTHIFIPVNGDRRSDHDTDAVKFGDGQETAGIHWSLLVISLIDNVAFHYDSMNGLNSPDARDLLKGFEAALPVSRSLRFVDMVDSPQQTDGWNCGIFALVIMKHLLLKRLLRADANQKITMSMKDQDIDYEGARKTIRTLIEERREEAIRKQSFNSDGVPSIPFQTADTTTTKRSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BZ44</accession>
    <name>A0A177BZ44_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CC84DRAFT_1180805</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441560">
        <property type="protein sequence ID" value="OAF99968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030334.1">
        <property type="nucleotide sequence ID" value="XM_018180509.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BZ44"/>
    <dbReference type="STRING" id="1460663.A0A177BZ44"/>
    <dbReference type="GeneID" id="28763995"/>
    <dbReference type="InParanoid" id="A0A177BZ44"/>
    <dbReference type="OrthoDB" id="3770802at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF10">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="10"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAF99968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="537" mass="60608" checksum="47E7E9949F38A850" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BZ93</accession>
    <name>A0A177BZ93_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Flavo protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_1102669</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HFCD (homooligomeric flavin containing Cys decarboxylase) superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV441560">
        <property type="protein sequence ID" value="OAF99901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030267.1">
        <property type="nucleotide sequence ID" value="XM_018174976.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BZ93"/>
    <dbReference type="STRING" id="1460663.A0A177BZ93"/>
    <dbReference type="GeneID" id="28758462"/>
    <dbReference type="InParanoid" id="A0A177BZ93"/>
    <dbReference type="OrthoDB" id="70387at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071513">
        <property type="term" value="C:phosphopantothenoylcysteine decarboxylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004633">
        <property type="term" value="F:phosphopantothenoylcysteine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1950">
        <property type="entry name" value="Flavin prenyltransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036551">
        <property type="entry name" value="Flavin_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003382">
        <property type="entry name" value="Flavoprotein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14359:SF21">
        <property type="entry name" value="FLAVOPROTEIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14359">
        <property type="entry name" value="HOMO-OLIGOMERIC FLAVIN CONTAINING CYS DECARBOXYLASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02441">
        <property type="entry name" value="Flavoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52507">
        <property type="entry name" value="Homo-oligomeric flavin-containing Cys decarboxylases, HFCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140860">
        <property type="entry name" value="Pseudo ankyrin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavoprotein" evidence="3">
        <location>
            <begin position="80"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="413"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAF99901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="575" mass="65613" checksum="A22CF68212D6E83C" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BZZ7</accession>
    <name>A0A177BZZ7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_363635</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441560">
        <property type="protein sequence ID" value="OAG00219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030584.1">
        <property type="nucleotide sequence ID" value="XM_018185926.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BZZ7"/>
    <dbReference type="GeneID" id="28769412"/>
    <dbReference type="InParanoid" id="A0A177BZZ7"/>
    <dbReference type="OrthoDB" id="10633669at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG00219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="169" mass="18383" checksum="EC3F11BE7F6E7768" modified="2016-09-07" version="1">MCRSNMSAAHVLDATAGVISVLGTRSLSRHRQKYDDSSEVHVNAGEGSGYAVLGCDMPRLPAHLHHHYSSSLIRLVTHPRYHPEPSLMQSYVACRPHTAILHAGANLRGGPGTAKLASEVGGARERRRHDWSACWRGARLGDQVFRARVSSAGVEGLAWAGPRVCRQDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C043</accession>
    <name>A0A177C043_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">MYND-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CC84DRAFT_1169052</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441560">
        <property type="protein sequence ID" value="OAG00222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030587.1">
        <property type="nucleotide sequence ID" value="XM_018179558.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C043"/>
    <dbReference type="STRING" id="1460663.A0A177C043"/>
    <dbReference type="GeneID" id="28763044"/>
    <dbReference type="InParanoid" id="A0A177C043"/>
    <dbReference type="OrthoDB" id="432970at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024119">
        <property type="entry name" value="TF_DEAF-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10237">
        <property type="entry name" value="DEFORMED EPIDERMAL AUTOREGULATORY FACTOR 1 HOMOLOG SUPPRESSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10237:SF15">
        <property type="entry name" value="LD37257P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01360">
        <property type="entry name" value="ZF_MYND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="6">
        <location>
            <begin position="102"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="140"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAG00222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="204" mass="21563" checksum="3AC2A14707CFCFCF" modified="2016-09-07" version="1">MPPRSVCLNVFTTSLGSGSVKKESEVVVRETKAGNGDGAAEERARHDSVQEDSIATSKPFAQAFTAAHTSPIASTTIDVATLPADIRGIVNPFFSTVLPTTCSTCTRPPPSGHSLLRCSRCKRAYYCSRTCQKQAWKTHKADCDPTSSPSPYSVLDTPDVSMPGSPATAADEHQFNLAAPVARDVASQCGAIQDAMYGLSTTAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C088</accession>
    <name>A0A177C088_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1168424</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441559">
        <property type="protein sequence ID" value="OAG00309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030674.1">
        <property type="nucleotide sequence ID" value="XM_018179392.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C088"/>
    <dbReference type="GeneID" id="28762878"/>
    <dbReference type="InParanoid" id="A0A177C088"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG00309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="68" mass="7170" checksum="1F4C581A50E1411B" modified="2016-09-07" version="1">MHPNVGRASVAQSSGAPRLRGRSPSSSTPILTTACWPWQPSSGPNQLTLTSTVQTSNLPPGNFRLNTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C0P9</accession>
    <name>A0A177C0P9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1209134</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441558">
        <property type="protein sequence ID" value="OAG01065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031430.1">
        <property type="nucleotide sequence ID" value="XM_018182202.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C0P9"/>
    <dbReference type="GeneID" id="28765688"/>
    <dbReference type="InParanoid" id="A0A177C0P9"/>
    <dbReference type="OrthoDB" id="5383526at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008057633" description="Secreted protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG01065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="178" mass="18628" checksum="5D72C70F77687052" modified="2016-09-07" version="1">MKLLCLLLLLFAAATLAIDIRFGGTKDCKGVVASCLNQAPNRCCYLPNGRQSSHISFGAVPGDWKITMRGHVGSNCDLAITAGGDSFGSGGNLQDYCYFGGSPAFIASGDYFFRSEKVDSSTNSPTDGSLVNGLILEDGTEYPLDGLDEDAIAEAVDAAFNGTIGSAIRKFKLSPLPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C0X6</accession>
    <name>A0A177C0X6_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_1262412</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441557">
        <property type="protein sequence ID" value="OAG01293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031658.1">
        <property type="nucleotide sequence ID" value="XM_018185152.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C0X6"/>
    <dbReference type="STRING" id="1460663.A0A177C0X6"/>
    <dbReference type="GeneID" id="28768638"/>
    <dbReference type="InParanoid" id="A0A177C0X6"/>
    <dbReference type="OrthoDB" id="3758860at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="171"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="475"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="499"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAG01293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="516" mass="58270" checksum="910FE2F0F685B774" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2023-06-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C0Y8</accession>
    <name>A0A177C0Y8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_290916</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441559">
        <property type="protein sequence ID" value="OAG00280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030645.1">
        <property type="nucleotide sequence ID" value="XM_018185764.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C0Y8"/>
    <dbReference type="GeneID" id="28769250"/>
    <dbReference type="InParanoid" id="A0A177C0Y8"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG00280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="164" mass="18282" checksum="28D1D5D7EE337B26" modified="2016-09-07" version="1">MRLSSSKASDIGVRRDWKSGLISSVHGLVMNDKRHVNPIGAWPTVPTLSAPHAPVAETQASRHFGFLFCLRYLRSVAWKSQGFPFLDGGVEPRRGDPNTNGRRTPNSVGTLYQPYFYNDEALAYSHAFSFFCKPQTPCARVAASGFLIDTTFSCRVCVRYNIMC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C1B2</accession>
    <name>A0A177C1B2_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Tyrosine specific protein phosphatases domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1129499</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441559">
        <property type="protein sequence ID" value="OAG00669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031034.1">
        <property type="nucleotide sequence ID" value="XM_018175835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C1B2"/>
    <dbReference type="STRING" id="1460663.A0A177C1B2"/>
    <dbReference type="GeneID" id="28759321"/>
    <dbReference type="InParanoid" id="A0A177C1B2"/>
    <dbReference type="OrthoDB" id="9988524at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004721">
        <property type="term" value="F:phosphoprotein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026893">
        <property type="entry name" value="Tyr/Ser_Pase_IphP-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31126:SF10">
        <property type="entry name" value="PROTEIN PHOSPHATASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G06650)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31126">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13350">
        <property type="entry name" value="Y_phosphatase3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="1">
        <location>
            <begin position="165"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG00669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="293" mass="32991" checksum="5569DC83BBF982C0" modified="2016-09-07" version="1">MSNTQPPLKSIPNFRDAGAFVNEQTEQRRVKTRLLYRGARPDDATNEDRRRLVEEYKLKSIIDLRTKTEHIEQAQKRDAKIKASAAVPQSNDAIAEPLKIPGVAYYEINFNGSSFSRMLISKLSWTEFFKLVWLMATGYRKDAIKILAPHMEEMGLVGLAIASVDVCTSEVKQVFDVLAKEENWPVLVHCTQGKDRTGLIVMLLLFLLEVDEAAIEKDYLLSGPELEAERAERVKEIQSIGLSEQFALCPPDVVSTVHAHVQEKYGGVEAYLLSTGITTEQVARIKRTLRSDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C1Z3</accession>
    <name>A0A177C1Z3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_271632</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441558">
        <property type="protein sequence ID" value="OAG00909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031274.1">
        <property type="nucleotide sequence ID" value="XM_018185689.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C1Z3"/>
    <dbReference type="GeneID" id="28769175"/>
    <dbReference type="InParanoid" id="A0A177C1Z3"/>
    <dbReference type="OrthoDB" id="3776815at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008057595" evidence="1">
        <location>
            <begin position="20"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG00909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="306" mass="32347" checksum="201AF8398D18BD79" modified="2016-09-07" version="1">MSPIPHWAAALLLATKATANFTTSYYLPNPNFLPSRIRFLASVIAADKDRVTLAARYDDDPDYAALDLNLDARFSMTMTLASTLYAQTTTYTAGGGEEEAAVDPVTIWIRRRCEIDVDMSGAQCTAEYNEALALRECYRAPPGLFDDTPVVSRVGTTWVTLPPETHTAGQSETLLWTFSDTDAAGVQTIVRPDPHAENYYSNPPPDWCSGFSQNYSNVVVPSSALTSSWTLQKSEMGLFGFTITAGEEKMAKATTGASVTVGSATPTATGTGAGAGRTGGGSAGAAPARTMAPALWGVGAAVAMFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C226</accession>
    <name>A0A177C226_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_1101722</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441558">
        <property type="protein sequence ID" value="OAG01211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031576.1">
        <property type="nucleotide sequence ID" value="XM_018174929.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C226"/>
    <dbReference type="STRING" id="1460663.A0A177C226"/>
    <dbReference type="GeneID" id="28758415"/>
    <dbReference type="InParanoid" id="A0A177C226"/>
    <dbReference type="OrthoDB" id="4682787at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF47">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="36"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="79"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="3"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAG01211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="137" mass="15793" checksum="DB49AD8A58CED004" modified="2016-09-07" version="1" fragment="single">IHIGSIFYGLVVMCLKIAILLDWLRLFVQQGQRWMFWTLHALIWANIIYYGSGTLIEVWRCHPHEKIWNPLFEGGSYPINIGANNFVSGIVNILSDFAILLLPQRRTWKLHISRPKRLGVSLLFANWTVVSTTSNVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C2K3</accession>
    <name>A0A177C2K3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">3-oxoacyl-[acyl-carrier-protein] reductase</fullName>
            <ecNumber evidence="2">1.1.1.100</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CC84DRAFT_1263131</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a (3R)-hydroxyacyl-[ACP] + NADP(+) = a 3-oxoacyl-[ACP] + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17397"/>
            <dbReference type="Rhea" id="RHEA-COMP:9916"/>
            <dbReference type="Rhea" id="RHEA-COMP:9945"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78776"/>
            <dbReference type="ChEBI" id="CHEBI:78827"/>
            <dbReference type="EC" id="1.1.1.100"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.100" evidence="2"/>
    <dbReference type="EMBL" id="KV441558">
        <property type="protein sequence ID" value="OAG01092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031457.1">
        <property type="nucleotide sequence ID" value="XM_018185212.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C2K3"/>
    <dbReference type="STRING" id="1460663.A0A177C2K3"/>
    <dbReference type="GeneID" id="28768698"/>
    <dbReference type="InParanoid" id="A0A177C2K3"/>
    <dbReference type="OrthoDB" id="417891at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004316">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050259">
        <property type="entry name" value="SDR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42879">
        <property type="entry name" value="3-OXOACYL-(ACYL-CARRIER-PROTEIN) REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42879:SF2">
        <property type="entry name" value="3-OXOACYL-[ACYL-CARRIER-PROTEIN] REDUCTASE FABG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAG01092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="258" mass="27249" checksum="85DBA11306891E79" modified="2016-09-07" version="1">MASFTDKVVIITGCSSGIGLATTQLFLSRQAKVFGIDIAPFTAETTKDVPFEFHQADLIEPQAASEAVARCTAIFGRIDVLVNCAGISDGWSSADSLKDVEWERVMAINLTVPVRLMTAVLPAMKEQGKGSIVNVASKAGVSGAAAGIAYTASKHGLVGATKNVAWRFRNDNIRCNAVLPGGVATNIQNSVNMDCFDKDGFSSFFPVVEMHVAKNEKGQPVPVITPNDVAKGIAYLASDEARMVNGALLPIDAAWSTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C2L0</accession>
    <name>A0A177C2L0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">MFS transporter-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CC84DRAFT_1101321</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Vesicular transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441558">
        <property type="protein sequence ID" value="OAG00870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031235.1">
        <property type="nucleotide sequence ID" value="XM_018174908.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C2L0"/>
    <dbReference type="STRING" id="1460663.A0A177C2L0"/>
    <dbReference type="GeneID" id="28758394"/>
    <dbReference type="InParanoid" id="A0A177C2L0"/>
    <dbReference type="OrthoDB" id="5086884at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17325">
        <property type="entry name" value="MFS_MdtG_SLC18_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050930">
        <property type="entry name" value="MFS_Vesicular_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001958">
        <property type="entry name" value="Tet-R_TetA/multi-R_MdtG-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23506">
        <property type="entry name" value="GH10249P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23506:SF23">
        <property type="entry name" value="GH10249P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01035">
        <property type="entry name" value="TCRTETA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="74"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="109"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="136"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="166"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="194"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="306"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="343"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="370"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="401"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="447"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="481"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="35"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="226"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="267"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="226"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAG00870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="510" mass="54994" checksum="DA9068CFD22ADF7C" modified="2016-09-07" version="1">MGIKEMARPRWLQSFTQHGAKPPYLLKYRSSEAFIVATIALAIFTDMFLYALIVPVVPFAIETRSHVNGSRVQYWVSVLIAIYAAALLFFSPVCGWLADRSLSRRSPLVVGLIALLGATILLDIGSSIGIMIAGRILQGTSAAVVWVVGLALLADTVPQERLAQAMGYVGAGMSIGILIGPLLGGVVFDRAGYGAVFGMAYALIGLDILLRLLLIEKKVAARWDPEAGGRKRSHNVESEEQKSNDAVPGSSNGLEKEAAVNMPTVPEQSTLGWPAQGPRENGRTPTKRRIRDRLPPLLSLLYSRRLLAALFGAMMQAAIMTAFDSVLTIHVANTFHWTSTGAALLFLPIVIPSFLGPIFGYLSDRYGGRYLATIGFLCACPPLVCLRYVDSNTIRDKVLICALLFLVGLSLTMTFPPFMAEISAVVEAKEKKMIADGMRGYGPGGAYAQAYALFNMAFAAGCTMGPLLAGFLVEQQGWSTMAWILGLLSAVAAVPTFFWMGGFLFAKAPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C2N9</accession>
    <name>A0A177C2N9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1262731</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441557">
        <property type="protein sequence ID" value="OAG01706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032071.1">
        <property type="nucleotide sequence ID" value="XM_018185169.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C2N9"/>
    <dbReference type="GeneID" id="28768655"/>
    <dbReference type="InParanoid" id="A0A177C2N9"/>
    <dbReference type="OrthoDB" id="3792376at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="386"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="421"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG01706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="459" mass="49999" checksum="C74A0A33FD786ABF" modified="2016-09-07" version="1">MNRPTAPRGRGLPRSRGMIFNTSPNPELSRRSTAGTPHSLRSSRKWSDRRSSRTPGLALPQPNSRQELSRDATWQTVSWSSEPPLELPTLDSELQDWCTKILEYLECESLEISPPSEDTTDIQSRETSWVTEAESSLPHLDILNWIEQQPPTRSLSLSGKGVKQQRRNATVFALPKVSLANPRASSAEYTCQTSTLFGSSREIFQIQSNNTSAPETSGEYHESPDTIGSHRIAPYHHPETVRILEGKGPFLLDARDISLSQFRGRRGDSDDTITLGSSEQLQSMLRRNRVDGNAAEGQVHPWSSGVFNKCADEIVTSLRNIQGAAAAGRSEGQPLPGVIKGAAAGANEEQVSPVVIEGATAAGDREDKPSPEEIEDNIISLLETMGTVGKNSRRRGQEKLASPGCARPAPHIESAGSGDRSSSVASPLPSLSIVDPTGTGSKQKRFGKLGRWWKGILKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C2Q9</accession>
    <name>A0A177C2Q9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_271697</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441558">
        <property type="protein sequence ID" value="OAG00920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031285.1">
        <property type="nucleotide sequence ID" value="XM_018185690.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C2Q9"/>
    <dbReference type="GeneID" id="28769176"/>
    <dbReference type="InParanoid" id="A0A177C2Q9"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG00920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="93" mass="10447" checksum="32E2251B20D33EA0" modified="2016-09-07" version="1">MGSNRRTSAVSPPSNHALLVYLSFQSSRVSRCSRVYNITQFLCAQLLGQLISLLGLSVWICSRRTSGALRGHARARFRRHLETLLRLSNESES</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C3A4</accession>
    <name>A0A177C3A4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">succinate-semialdehyde dehydrogenase [NAD(P)(+)]</fullName>
            <ecNumber evidence="6">1.2.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CC84DRAFT_1252834</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>succinate semialdehyde + NAD(+) + H2O = succinate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:13217"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57706"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.2.1.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>succinate semialdehyde + NADP(+) + H2O = succinate + NADPH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:13213"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:57706"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.2.1.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid degradation; 4-aminobutanoate degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.16" evidence="6"/>
    <dbReference type="EMBL" id="KV441556">
        <property type="protein sequence ID" value="OAG02224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032589.1">
        <property type="nucleotide sequence ID" value="XM_018184368.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C3A4"/>
    <dbReference type="STRING" id="1460663.A0A177C3A4"/>
    <dbReference type="GeneID" id="28767854"/>
    <dbReference type="InParanoid" id="A0A177C3A4"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004777">
        <property type="term" value="F:succinate-semialdehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009450">
        <property type="term" value="P:gamma-aminobutyric acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07103">
        <property type="entry name" value="ALDH_F5_SSADH_GabD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000004">
        <property type="entry name" value="Succinate-semialdehyde dehydrogenase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000005">
        <property type="entry name" value="Succinate-semialdehyde dehydrogenase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050740">
        <property type="entry name" value="Aldehyde_DH_Superfamily"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43353:SF7">
        <property type="entry name" value="SUCCINATE SEMIALDEHYDE DEHYDROGENASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43353">
        <property type="entry name" value="SUCCINATE-SEMIALDEHYDE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="9">
        <location>
            <begin position="58"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00050387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00052698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00067047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAG02224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="528" mass="57688" checksum="4E86D375FDBDD3DB" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C3G6</accession>
    <name>A0A177C3G6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1262503</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441557">
        <property type="protein sequence ID" value="OAG01422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031787.1">
        <property type="nucleotide sequence ID" value="XM_018185156.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C3G6"/>
    <dbReference type="GeneID" id="28768642"/>
    <dbReference type="InParanoid" id="A0A177C3G6"/>
    <dbReference type="OrthoDB" id="10582613at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG01422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="144" mass="14374" checksum="D3E61A6D91AB79CD" modified="2016-09-07" version="1">MRQAAWDGKGTSARVEKQGAGAFAQAVVLSAAGDGVSGRRSGALGRMGMAREGATAGCTSPVAPSSAQRTPAPSLAAAAWESQRRRKGAAKGSLFVLTVRAARAHSLRGLPPAALLAAGHAPAAQAASTGCPHTTARCFRSVAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C3H0</accession>
    <name>A0A177C3H0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1208790</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441557">
        <property type="protein sequence ID" value="OAG01711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032076.1">
        <property type="nucleotide sequence ID" value="XM_018182183.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C3H0"/>
    <dbReference type="GeneID" id="28765669"/>
    <dbReference type="InParanoid" id="A0A177C3H0"/>
    <dbReference type="OrthoDB" id="3796810at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="209"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="286"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="340"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="510"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="622"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="216"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="343"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="401"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="511"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG01711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="761" mass="83597" checksum="961EC841B4D1D64A" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C412</accession>
    <name>A0A177C412_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Phospholipase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CC84DRAFT_1228540</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441557">
        <property type="protein sequence ID" value="OAG01457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031822.1">
        <property type="nucleotide sequence ID" value="XM_018183644.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C412"/>
    <dbReference type="STRING" id="1460663.A0A177C412"/>
    <dbReference type="GeneID" id="28767130"/>
    <dbReference type="InParanoid" id="A0A177C412"/>
    <dbReference type="OrthoDB" id="1658288at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047499">
        <property type="term" value="F:calcium-independent phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019369">
        <property type="term" value="P:arachidonate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046486">
        <property type="term" value="P:glycerolipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07216">
        <property type="entry name" value="Pat17_PNPLA8_PNPLA9_like3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24185">
        <property type="entry name" value="CALCIUM-INDEPENDENT PHOSPHOLIPASE A2-GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24185:SF1">
        <property type="entry name" value="CALCIUM-INDEPENDENT PHOSPHOLIPASE A2-GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 4" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="3 4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PNPLA" evidence="5">
        <location>
            <begin position="9"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXGXXG" evidence="4">
        <location>
            <begin position="13"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXSXG" evidence="4">
        <location>
            <begin position="55"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="DGA/G" evidence="4">
        <location>
            <begin position="186"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAG01457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="334" mass="36820" checksum="ADA41A9A89E51F04" modified="2016-09-07" version="1">MSYDGLCFLSLDGGGVRGLSTLYILREIMAALNHAREEAGLLAVKRCDVFGLIGGTSTGGLIAIMLGRLGMDVDDCISAYNALIEAIFTEREIRTGLGFKGNVEAKFSSQKLRECIENPGVSRGCRVFVCSCDRNNTRRIIRLRSYDIPGKPRSMNRPSVVQVALATSAAPRLFDEVNIGDVVHLDGGLDANNPVNHVAHEASDILCKEGGDPNLQARIKCFLSIGTGHPGVKAVHLDNAWKLISATLKEMVTDTQKDAHEFAHSWRRPLSQGRYFRFNVRHGLYDISLHGYKEKGKVETMTLSYLEEQDAEQSVRKCVKAMENKECVSIPDFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C460</accession>
    <name>A0A177C460_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1166374</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG02534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032899.1">
        <property type="nucleotide sequence ID" value="XM_018178946.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C460"/>
    <dbReference type="STRING" id="1460663.A0A177C460"/>
    <dbReference type="GeneID" id="28762432"/>
    <dbReference type="InParanoid" id="A0A177C460"/>
    <dbReference type="OrthoDB" id="5226911at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42354">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42354:SF1">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="321"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="376"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="219"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="392"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG02534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="407" mass="44872" checksum="2F7D29B70C842E61" modified="2016-09-07" version="1">MKAQAERSAGNGEVASCVSNLIHAFTDGLNVFKRLRERRRKRKSKHRERESSAPFEPELQLSNSLRKGPVELREKYESCYGDKGEKFAKGDAIAHASLVETLIKFNTGLVRIIATFLHQDSKSSDLQLDYKSLTSLSDISRREAVDSLNSLYQRLSQSQLQLHRRSESRGDPEKKKRSSSRQRSQGPTVTRVSVKTIGTTGSSKQTQLAMVRPRNARKGSMSSSSGSSKAPSTNVSSPYTTPPRSPPLPEYSPNDPFPPPKAPATKGNSTAPKKPALSIDTGRPTTWPQPKATKAAAFTNSLPTPPEYFAMKSLPPHLPLPFSNATHNIPRRRADKPTPSTYTFASDSTKLGEIPQRNWTVPFNYEEAERLNAEAAVKGHPVTRAPADQKAKTRKGLRSLFKKGQAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C4K6</accession>
    <name>A0A177C4K6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CC84DRAFT_1150678</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG02674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033039.1">
        <property type="nucleotide sequence ID" value="XM_018176715.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C4K6"/>
    <dbReference type="FunCoup" id="A0A177C4K6">
        <property type="interactions" value="36"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177C4K6"/>
    <dbReference type="GeneID" id="28760201"/>
    <dbReference type="InParanoid" id="A0A177C4K6"/>
    <dbReference type="OrthoDB" id="5428495at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015851">
        <property type="term" value="P:nucleobase transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.4160.10:FF:000002">
        <property type="entry name" value="Purine-cytosine permease fcyB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4160.10">
        <property type="entry name" value="Hydantoin permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026030">
        <property type="entry name" value="Pur-cyt_permease_Fcy2/21/22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31806">
        <property type="entry name" value="PURINE-CYTOSINE PERMEASE FCY2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31806:SF8">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G03000)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002744">
        <property type="entry name" value="Pur-cyt_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="61"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="95"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="139"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="170"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="200"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="241"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="270"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="327"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="366"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="391"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="432"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="467"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR002744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAG02674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="499" mass="54536" checksum="5DCE2C3D4ED2FF24" modified="2016-09-07" version="1">MEKGLSYDDAVTEVVQMGISEPVNKLEQWANKLDAIAGIEARGIDRIPEELRERVLSTKDYLNMFIIWFSMNCTANQMTMGVLGPVTYHLSLTESILICMFGTIFGSVCTGYISTFGPRSGLRTLNVAKYTMGWWPSKLCVILNLVIELGYGLIDCLVGGLLLSAVNGEGMSVIVGIVIVAVITWVFATFGIKWFHKFEAFVWAPTVLVLFVLIGVAGPHFDTTTPSKGSGATLAGNRISYFFLTASGPLSWSSAAADYVTYYPKSTNKYLVFATTTGGIVLGKLLIEFLGIGLGSGLLKNASWEAAFDSQGIGALVVESYGPLGGFGKFCCVVLALCIAANCIPGTYAAALNWQQLGAPFAKVPRVIWSTFSCIVFTIIAIAGRDRLFDIFINWLSLIGYWTIIWITMTVQDEFLFRKGQFDWEIWNRKDLLPHGYAALFTFVVGWVGAILGMYQTWYTGPLGGLIGQGADIGLPIAFAWAAVIYPPARWLELKVVGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C673</accession>
    <name>A0A177C673_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1178474</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG02906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033271.1">
        <property type="nucleotide sequence ID" value="XM_018180346.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C673"/>
    <dbReference type="GeneID" id="28763832"/>
    <dbReference type="InParanoid" id="A0A177C673"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG02906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="150" mass="16790" checksum="406BF25688E3A5BB" modified="2016-09-07" version="1">MPMAISHSDLTHIPTPEAGLKSSAFSSPSPLREMIDCPRRDQDSRSIDRPVGDDPAAQRGLLKTRNEFLAHSNPSSVASEKGKMLGLISIGLGYFHKHLTGLKMPRTHMKSLLYDLRHYACHQSHEMPGRKECMGFLVKRKEDSHRLSST</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C6K7</accession>
    <name>A0A177C6K7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">FAD/NAD(P)-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CC84DRAFT_1125168</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG03036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033401.1">
        <property type="nucleotide sequence ID" value="XM_018175713.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C6K7"/>
    <dbReference type="STRING" id="1460663.A0A177C6K7"/>
    <dbReference type="GeneID" id="28759199"/>
    <dbReference type="InParanoid" id="A0A177C6K7"/>
    <dbReference type="OrthoDB" id="655030at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051704">
        <property type="entry name" value="FAD_aromatic-hydroxylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46865:SF2">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46865">
        <property type="entry name" value="OXIDOREDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="4">
        <location>
            <begin position="6"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAG03036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="421" mass="45801" checksum="DC1D893F3549C5BB" modified="2016-09-07" version="1">MSKPHALVVGASIAGPMTAYWLAKAGFRITVIERFPKFRPGGQNIDIRTSGVTVMHKIPGMEPAVRAKIIPQDSIQFVNSKGKPYATMKPTGDPNQQNLISEYEIFRDDLSKILYDLTKDNPNVRYVFGEQVSAIHQEEKGKVTVEFQEGKLSRQDYDLVVACDGATSRTRALGFDSTVRTHMHPMNMWCAYASVPTDYLNGSKAATMYGSIGGRAVAFGPDPTGGNRVCALAVLPQKEVDATLPFRKAQKEGDDALRKYVGQHFASVGWKTADEVVQALTAAPDFYASENVQIKLPSLSRGRFTLVGDAGYAAGPTGGGTTLAMTGGYVLAGELLRHKGDIDAGLSAYEAIMRPVIDDMQRIPPGVPTAIAPQTWWGIAIRDAVLVAVTWGNAMFGWVLKYLAPSFGGDNYNLPEYEWVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C7C5</accession>
    <name>A0A177C7C5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Chaperone protein dnaJ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CC84DRAFT_857578</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG03543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033908.1">
        <property type="nucleotide sequence ID" value="XM_018187641.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C7C5"/>
    <dbReference type="FunCoup" id="A0A177C7C5">
        <property type="interactions" value="427"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177C7C5"/>
    <dbReference type="GeneID" id="28771127"/>
    <dbReference type="InParanoid" id="A0A177C7C5"/>
    <dbReference type="OrthoDB" id="550424at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10747">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10719">
        <property type="entry name" value="DnaJ_zf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.230.10:FF:000002">
        <property type="entry name" value="Molecular chaperone DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.230.10">
        <property type="entry name" value="Heat shock protein DnaJ, cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.260.20">
        <property type="entry name" value="Urease metallochaperone UreE, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044713">
        <property type="entry name" value="DNJA1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001305">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036410">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43888">
        <property type="entry name" value="DNAJ-LIKE-2, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00684">
        <property type="entry name" value="DnaJ_CXXCXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57938">
        <property type="entry name" value="DnaJ/Hsp40 cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="HSP40/DnaJ peptide-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51188">
        <property type="entry name" value="ZF_CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="1 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008057822" evidence="7">
        <location>
            <begin position="19"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="8">
        <location>
            <begin position="21"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="CR-type" evidence="9">
        <location>
            <begin position="144"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="CR-type" evidence="6">
        <location>
            <begin position="144"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAG03543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="417" mass="47357" checksum="5B46A2CA8AED2D07" modified="2016-09-07" version="1">MLLRILFLLGCLALGVLAAEDFYKLLGVKKDASERELKKAYRQLSKKYHPDKNPGDDSAHEKFVAVAEAYEVLVDAESRKIYDQYGHEGIKQHKQGGSPRQHHDPFDLFSRFFGGSGHFQGGGQRQGPNMELRVAVPLRDFYNGRVTEFEVEKQAICSACEGTGSEDGHVETCDACGGRGARIQRQQLAPGLFQQMQVQCDKCNGKGKTIAHPCPVCGGSRVVREPEKHELHIEKGMPLGVRITYENEADESPDWVAGDLIVHLAETDPQHGQQDHERTDGTFFRRRGKDLFWREVLSLREAWMGDWTRNITHLDGHIVQLSRKRGEVVQPNHVEVIADEGMPVWHQELENNAGEVYGSLHVEYVVVLPDQMEKGMEKDFWGVWEKYRKKSGKVLDEEWGRPKEPIIMPGKEEHDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C7U1</accession>
    <name>A0A177C7U1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_1250899</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG02919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033284.1">
        <property type="nucleotide sequence ID" value="XM_018184315.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C7U1"/>
    <dbReference type="STRING" id="1460663.A0A177C7U1"/>
    <dbReference type="GeneID" id="28767801"/>
    <dbReference type="InParanoid" id="A0A177C7U1"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11065">
        <property type="entry name" value="CYP64-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF4">
        <property type="entry name" value="CYTOCHROME P450 98A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0349">Heme</keyword>
    <keyword evidence="4 5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="456"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAG02919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="537" mass="60949" checksum="234B141216BA3316" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C7W1</accession>
    <name>A0A177C7W1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NTF2-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1096447</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG03834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034199.1">
        <property type="nucleotide sequence ID" value="XM_018174668.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C7W1"/>
    <dbReference type="STRING" id="1460663.A0A177C7W1"/>
    <dbReference type="GeneID" id="28758154"/>
    <dbReference type="InParanoid" id="A0A177C7W1"/>
    <dbReference type="OrthoDB" id="5440at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030638">
        <property type="term" value="P:polyketide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009959">
        <property type="entry name" value="Cyclase_SnoaL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38436:SF3">
        <property type="entry name" value="CARBOXYMETHYLENEBUTENOLIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38436">
        <property type="entry name" value="POLYKETIDE CYCLASE SNOAL-LIKE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG03834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="404" mass="45426" checksum="12C5AF0B8291E9F1" modified="2016-09-07" version="1">MALNYLTTSQGWLSFSHSTPTLFVTAEDDDFDVETLRAWRDEGFVVKYVPMGKGGKTYVNTLHHLGDGMSIGERYAIVAFGDAAAVCLEVYSEPKTSTSKLCSLIAYYPSSIPDPRHRLSSSFRVLVHLAQGTGEGDTVGVQRRPEVLGIQGRRKIVQKRITPGIGTGGLQSKIPYPVYTYEGVDAGFAEHDLDEYDAVADALAWSRSLSMVRRGFGAEVDLERVWEENEDQKYHKRSAKKIMETYTTEPTPTVNYTATLTGGQGHEEIFRFYNEYFMADKLPIFHLRLISRTIGADRIVDELYVQFKHTIDMPWVLPSVKPTGRKVEIVVVSIVGMRGGKVWSERIYWDQASVLFQVGLLDPDQVPEEARKQGLEMLPVAGSEAARKIMDFESEDTNDMIDDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C8U4</accession>
    <name>A0A177C8U4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">gamma-glutamylcyclotransferase</fullName>
            <ecNumber evidence="1">4.3.2.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CC84DRAFT_886100</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EC" id="4.3.2.9" evidence="1"/>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG04063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034428.1">
        <property type="nucleotide sequence ID" value="XM_018187787.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C8U4"/>
    <dbReference type="STRING" id="1460663.A0A177C8U4"/>
    <dbReference type="GeneID" id="28771273"/>
    <dbReference type="InParanoid" id="A0A177C8U4"/>
    <dbReference type="OrthoDB" id="2924818at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003839">
        <property type="term" value="F:gamma-glutamylcyclotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd06661">
        <property type="entry name" value="GGCT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.490.10">
        <property type="entry name" value="Gamma-glutamyl cyclotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009288">
        <property type="entry name" value="AIG2-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017939">
        <property type="entry name" value="G-Glutamylcylcotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013024">
        <property type="entry name" value="GGCT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036568">
        <property type="entry name" value="GGCT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12935">
        <property type="entry name" value="GAMMA-GLUTAMYLCYCLOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12935:SF0">
        <property type="entry name" value="GAMMA-GLUTAMYLCYCLOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06094">
        <property type="entry name" value="GGACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110857">
        <property type="entry name" value="Gamma-glutamyl cyclotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma-glutamylcyclotransferase AIG2-like" evidence="5">
        <location>
            <begin position="18"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="95"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="18"/>
            <end position="23"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR617939-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR617939-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF06094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAG04063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="215" mass="23983" checksum="221C61598301C771" modified="2016-09-07" version="1">MMPPRTAPQKTLAEPTLYFAFGSNLWLSQMRTRCPSSAYLGVARLHGYTWIINERGYANVVESKARPIANTKPDHVYGLVFRLDANDEAKLDKNEGVPIAYTKECLSVDFWAARGPNDSVDTTRPPTEVGQDMLVYIDRRRVTPSTPKDEYVYRINRGVEDAVRLGVPNAYIEGTVRRFVPAEEEGNKGRKSVEEVAKKQAAGFVDKALGVDGES</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C8X1</accession>
    <name>A0A177C8X1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1261870</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG03289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033654.1">
        <property type="nucleotide sequence ID" value="XM_018185107.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C8X1"/>
    <dbReference type="FunCoup" id="A0A177C8X1">
        <property type="interactions" value="27"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177C8X1"/>
    <dbReference type="GeneID" id="28768593"/>
    <dbReference type="InParanoid" id="A0A177C8X1"/>
    <dbReference type="OrthoDB" id="2898509at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052228">
        <property type="entry name" value="Sec_Metab_Biosynth_Oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47534:SF3">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE-LIKE C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47534">
        <property type="entry name" value="YALI0E05731P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG03289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="343" mass="37280" checksum="5E3FBFE4C5EDADA4" modified="2016-09-07" version="1">MVSLPQVLASNARIATSLPPDLVAVFAGATTGIGRATLKAFVKYAVAPRIYLFARNTDAAAQVVGECTEINPKCEIEVVKVDLSSMRETEAACEVVLAKEQRVNLLVLSMGEVRADRALSNEGLHLVLATVYYARILIPALLLPLLTHASTHTPLARVLDIAGGTKEGPVDLADLAALRLPMSKIRGQLSSMHTLSLESLAERAPMVSFVHDFPGAVVTPLFEGVPGWAGWMMWVLGMYLRLFQRWVCVPLEECAERQVFLGTSAKYAAGEGDAGGVELADGVERGQATEQVRSCVYSVDWDGEGPGERVLKLLKGLRREGVREVVWEHTNGEFERIRRGKGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C9F5</accession>
    <name>A0A177C9F5_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RNA polymerase II transcription factor SIII subunit A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1165701</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG03469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033834.1">
        <property type="nucleotide sequence ID" value="XM_018178778.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C9F5"/>
    <dbReference type="STRING" id="1460663.A0A177C9F5"/>
    <dbReference type="GeneID" id="28762264"/>
    <dbReference type="InParanoid" id="A0A177C9F5"/>
    <dbReference type="OrthoDB" id="21513at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070449">
        <property type="term" value="C:elongin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051870">
        <property type="entry name" value="Elongin-A_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010684">
        <property type="entry name" value="RNA_pol_II_trans_fac_SIII_A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15141">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR B POLYPEPTIDE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15141:SF76">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR B POLYPEPTIDE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06881">
        <property type="entry name" value="Elongin_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="213"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="91"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="230"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG03469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="304" mass="33958" checksum="EC67DB17315F9709" modified="2016-09-07" version="1">MPVPSLFHLAKTRLVQNIHMLEDIGDLPYAFLAPVLRQIQIPDQLVQLETNCPQIQGETGEIWLRLIKRDIPGWEKKPHQPRDPKNWSKVYKKLKKEAAAEEEAQQEALRQKMQALQKDRNGHQTTIINANLNLPSARRSGWSFGGGARSGWGDPAAPKKTGKVAFDKLKRGIYDAKRARPAASRTPAHILNENRRMVTQVPARMVRMAEAEALSQGPRRMLVPKPEAPPAAATGTSTTRRPIIRQQPMPRVSDAAPERAERPRLPAGQQFSAPRPVPKPQPAAPSLKRRAGPNILVESKRRKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CA91</accession>
    <name>A0A177CA91_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1121234</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG04664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035029.1">
        <property type="nucleotide sequence ID" value="XM_018175604.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CA91"/>
    <dbReference type="GeneID" id="28759090"/>
    <dbReference type="InParanoid" id="A0A177CA91"/>
    <dbReference type="OrthoDB" id="5421765at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="254"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG04664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="274" mass="30423" checksum="6A81B99E684B4EA2" modified="2016-09-07" version="1">MHREKGATANVVSISNGSPITSTLENGLPQPLEDQAISGEISKISNLIKNHVQSYYHSRTVSPGMIDYDDLQALGENLPVSVGTLSTLLNNSATREIALRFILAWVVTSRIQLNNSSNTTFLPPEVAKCMQSMNHAEHPSRVHSLLYTKWRALTAELLQPTHVRNPFSGSDGRIRNIQAAATLLDSVLRPFADSRMDDGARSRNLEEMLKRSAQFAFTLFSQPSAWDFDWQDEQSVKSGSLCIFPALVQVADENGEPLHPPRPFSEAVNRRLDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CAG0</accession>
    <name>A0A177CAG0_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Splicing factor YJU2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CC84DRAFT_1165052</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Part of the spliceosome which catalyzes two sequential transesterification reactions, first the excision of the non-coding intron from pre-mRNA and then the ligation of the coding exons to form the mature mRNA. Plays a role in stabilizing the structure of the spliceosome catalytic core and docking of the branch helix into the active site, producing 5'-exon and lariat intron-3'-intermediates.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the spliceosome. Present in the activated B complex, the catalytically activated B* complex which catalyzes the branching, the catalytic step 1 C complex catalyzing the exon ligation, and the postcatalytic P complex containing the ligated exons (mRNA) and the excised lariat intron.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the CWC16 family. YJU2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG04643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035008.1">
        <property type="nucleotide sequence ID" value="XM_018178633.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CAG0"/>
    <dbReference type="FunCoup" id="A0A177CAG0">
        <property type="interactions" value="697"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CAG0"/>
    <dbReference type="GeneID" id="28762119"/>
    <dbReference type="InParanoid" id="A0A177CAG0"/>
    <dbReference type="OrthoDB" id="674963at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071006">
        <property type="term" value="C:U2-type catalytic step 1 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000349">
        <property type="term" value="P:generation of catalytic spliceosome for first transesterification step"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03226">
        <property type="entry name" value="YJU2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007590">
        <property type="entry name" value="Saf4/Yju2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043701">
        <property type="entry name" value="Yju2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12111">
        <property type="entry name" value="SPLICING FACTOR YJU2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12111:SF1">
        <property type="entry name" value="SPLICING FACTOR YJU2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04502">
        <property type="entry name" value="Saf4_Yju2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="5 8" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="190"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="113"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="190"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="214"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OAG04643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="287" mass="32737" checksum="87E9E18B89300A76" modified="2016-09-07" version="1">MSERKVLSKYYPPDFDPSKIGRTRGPKQAGPKVQTVRLMAPFSMKCTSCGEFIYKGRKFNARKETTEEKYYQIAIFRFYIRCTRCSAEITFKTDPKNMDYECERGAKRNFEPWREAKLAEETEEERLDRLEREEAERDAMKELETKVLDAKQEMAIADALDEIRSRNARIERAEKEGKKAEVTVVDVDEARRRQEEQDEEAARKAFAGRSMPDIGEEEIAEEEMNDAPMEVPVMAFTKKPKEKKDYGAALGIKKKDSKPSMPAPAPSTKQSAPPSSGLLAGYGSDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CAJ2</accession>
    <name>A0A177CAJ2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">C2H2 type zinc finger domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_1095266</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG03862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034227.1">
        <property type="nucleotide sequence ID" value="XM_018174610.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CAJ2"/>
    <dbReference type="STRING" id="1460663.A0A177CAJ2"/>
    <dbReference type="GeneID" id="28758096"/>
    <dbReference type="InParanoid" id="A0A177CAJ2"/>
    <dbReference type="OrthoDB" id="40579at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47660:SF8">
        <property type="entry name" value="TRANSCRIPTION FACTOR WITH C2H2 AND ZN(2)-CYS(6) DNA BINDING DOMAIN (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47660">
        <property type="entry name" value="TRANSCRIPTION FACTOR WITH C2H2 AND ZN(2)-CYS(6) DNA BINDING DOMAIN (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="7">
        <location>
            <begin position="231"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="96"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="102"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAG03862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="712" mass="80216" checksum="5D7A5F2C3D6C6FE2" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CAT8</accession>
    <name>A0A177CAT8_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">cyclin-dependent kinase</fullName>
            <ecNumber evidence="2">2.7.11.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CC84DRAFT_800514</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="2"/>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG04685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035050.1">
        <property type="nucleotide sequence ID" value="XM_018187463.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CAT8"/>
    <dbReference type="STRING" id="1460663.A0A177CAT8"/>
    <dbReference type="GeneID" id="28770949"/>
    <dbReference type="InParanoid" id="A0A177CAT8"/>
    <dbReference type="OrthoDB" id="204883at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008024">
        <property type="term" value="C:cyclin/CDK positive transcription elongation factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030332">
        <property type="term" value="F:cyclin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008353">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07840">
        <property type="entry name" value="STKc_CDK9_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000440">
        <property type="entry name" value="Serine/threonine-protein kinase bur1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000270">
        <property type="entry name" value="Serine/threonine-protein kinase bur1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF546">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="799"/>
            <end position="1084"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1110"/>
            <end position="1161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="46"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="69"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="107"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="177"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="222"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="256"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="297"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="318"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="363"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="402"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="452"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="483"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="507"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="533"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="563"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="733"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="828"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OAG04685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="1161" mass="134216" checksum="30F17D1BC6B29018" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CCZ6</accession>
    <name>A0A177CCZ6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1165131</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG04752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035117.1">
        <property type="nucleotide sequence ID" value="XM_018178648.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CCZ6"/>
    <dbReference type="STRING" id="1460663.A0A177CCZ6"/>
    <dbReference type="GeneID" id="28762134"/>
    <dbReference type="InParanoid" id="A0A177CCZ6"/>
    <dbReference type="OrthoDB" id="4708870at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="251"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG04752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="394" mass="45003" checksum="1853D9DCBE465666" modified="2016-09-07" version="1">MGGQAFAHIVSDTPINVPRMLPDTYNQVASDVKLKLETLFRHVTIPRDAPGKSDFGDIDLLVEGIRDPINNKDIWATVKDVLGAELYVSPHHFGIKHPTIPDAYVQVDVELSPGNDTKDGEELFEWTTFMKSDSDLLQIIGVVHRSLGITCNDKGMHIRVEEVEPYNRKKSMVFLTRDPDQAMDFYGYDKAKYYQGFDSETELFDWATNGRYFHWKVYQDCEENSNDRSRINKRAMFRRFVYKYMPSCGNGTKTSSHTEDDESDTKKAAPSRQEVLQDALLMFGRHKEYNAIISEHKTQGVEEAIWLQINNSISSDNAARGTILKGLKRWVAFKDGHPYVTEQPISTSTKLKWSEHVSNDALPEISSWIAENQEQIGKLEEERANEARKAGMKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2023-06-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CDT6</accession>
    <name>A0A177CDT6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_809868</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG04938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035303.1">
        <property type="nucleotide sequence ID" value="XM_018187507.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CDT6"/>
    <dbReference type="GeneID" id="28770993"/>
    <dbReference type="InParanoid" id="A0A177CDT6"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG04938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="88" mass="10379" checksum="22C12B2EDCBAF7B7" modified="2016-09-07" version="1">MPASLDLVPRLTSEKARRLRSFDRRHRSLLEHEFALCFDGSHRSEFVRRQHLNYGLALTSCVCGGEFSPDRSIRIWQYGMIVSQRRRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CDZ7</accession>
    <name>A0A177CDZ7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Integral membrane protein-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CC84DRAFT_1144832</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG05451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035816.1">
        <property type="nucleotide sequence ID" value="XM_018176472.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CDZ7"/>
    <dbReference type="FunCoup" id="A0A177CDZ7">
        <property type="interactions" value="17"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CDZ7"/>
    <dbReference type="GeneID" id="28759958"/>
    <dbReference type="InParanoid" id="A0A177CDZ7"/>
    <dbReference type="OrthoDB" id="4137487at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd08760">
        <property type="entry name" value="Cyt_b561_FRRS1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018825">
        <property type="entry name" value="DUF2427"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018827">
        <property type="entry name" value="YTP1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31685">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_6G12730)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31685:SF2">
        <property type="entry name" value="PROTEIN YTP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10348">
        <property type="entry name" value="DUF2427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10355">
        <property type="entry name" value="Ytp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008058068" description="Integral membrane protein-like protein" evidence="2">
        <location>
            <begin position="28"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="186"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="282"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="311"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="347"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="385"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2427" evidence="3">
        <location>
            <begin position="35"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="Protein YTP1-like C-terminal" evidence="4">
        <location>
            <begin position="162"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAG05451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="470" mass="52222" checksum="0A4454548CD9D807" modified="2016-09-07" version="1">METSARLLTRGLAFGVLVLLSATSVTAHEHHMDNIPEGSAISDDPIDSILWTHILVQAVAWGILFPTGMVLGIIRSRWHVPVQTIGSILALIGYFLGHKHKGRQFAPNAHAKFVPTLMFTLLSQIIMGIYLKLHLEKGIHGKIRKVVVKAHGWVGKLMPIVSWVQFVLGGIASMGFCRADHMGQCLAHFIMGSAFIAYGILLTILLLVGQVWLRRSGRSQEFFDSLVIAAWGCVNTFTEHRWGSAWVGNDLQHTTMGIIWWCAGLVGIWLSRSRNGRPKRNLIPGIVILLTGWGMSAHAQHLPISTMVHTIFGYTLMAAGLTRIIEISFVLKDRNTLSEDGTDPNSFQYLTPFLLFASGFLFMGATEEQMQILADAHITHVSYVFILYSLAFLLFLFVNMLIHLYAVHAWGQDTKNDAEAPRANGAPNGYARVDSRVRDAEEFELDGLVSEDEDAVAIEDKERQPLTSRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CE61</accession>
    <name>A0A177CE61_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF1996 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1218415</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG05020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035385.1">
        <property type="nucleotide sequence ID" value="XM_018182993.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CE61"/>
    <dbReference type="STRING" id="1460663.A0A177CE61"/>
    <dbReference type="GeneID" id="28766479"/>
    <dbReference type="InParanoid" id="A0A177CE61"/>
    <dbReference type="OrthoDB" id="74764at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018535">
        <property type="entry name" value="DUF1996"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43662">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43662:SF13">
        <property type="entry name" value="DUF1996 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09362">
        <property type="entry name" value="DUF1996"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008058168" description="DUF1996 domain-containing protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1996" evidence="2">
        <location>
            <begin position="32"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG05020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="344" mass="38693" checksum="DA2998AA58B2386F" modified="2016-09-07" version="1">MYWTSLIALALIRPSQALIRFGCSQLVVDRLDPLVNPGMEPSPHLHQIIGGNSFNASMYKEDHDLAKLSTCTSCQPSEDFSNYWTASLFFRARNGTYKRVPQKGNVGFEAQRGGMTVYYMQASLGDFQQKAKVKAFQPGFRMLIGSPSASTKPEADKYPQLTYTCLQDMNTRYPETKDFPAKPCPAGIMVNLRFPTCWNGVDLDSPDHISHMSYPANGTFENQGPCPASHPVRVAQVMYEVIFETKAFNKKADWPTDGSQPFVWSFGDTTGFGNHGDYVFGWKDDSLQKILDEECYVQCKTMKTQSIEEMNRCSIPKKVDEDVGDDAWIDAIPDETAIRFWSSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CFZ5</accession>
    <name>A0A177CFZ5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">FAD-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CC84DRAFT_1164785</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG06533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036898.1">
        <property type="nucleotide sequence ID" value="XM_018178561.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CFZ5"/>
    <dbReference type="STRING" id="1460663.A0A177CFZ5"/>
    <dbReference type="GeneID" id="28762047"/>
    <dbReference type="InParanoid" id="A0A177CFZ5"/>
    <dbReference type="OrthoDB" id="415825at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF39">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="6">
        <location>
            <begin position="35"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAG06533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="506" mass="54246" checksum="B2FA3FC3AC0FBD7B" modified="2016-09-07" version="1">MADLRTALPATCDVLVPTPDTKVDELLPNRWSRTLISAPHAIVIPTTIPDIVATIKYATSHDLKLIPSGGARGFFVPITHDVIYLDLRHFSSFQLNEEKREVTFGGGCISGPLLKGLAEKGWYTGTPSGNGVGMTGALLGGLNHPLVGLHGMGRDMVKSFTIVPFSMPYGGELGAVTVTRDSENEEKKLFDVLRGAGHGMGVVVSATMEAHPLAGLELEGRDKVWQRTLAFPPNAIDAAGDAYLALHTHAPPNLSFFIGFMRAPPNAPRPGAPVILLAVSFFGPVATAEIATSITFSDAVLSKTVNATTTLTPFGDIHNALDPLNAPGGYKELHGASVKSIRASSLTRAFASFLSYTDGRPELFGTAVIFPASNTAKSESLAAKEDFYNPRDRGIFVQVKTSCPAADDKDEADAFAKSVHEIAREEDRKAGRRDWGFANNMVEGMDLKDVYTPEQIGEIARVASFWNKGGVGWCPTAAAWRWYTWSRENGGKPGTILQALVDEVGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CG69</accession>
    <name>A0A177CG69_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7730 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1204337</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG06584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036949.1">
        <property type="nucleotide sequence ID" value="XM_018181896.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CG69"/>
    <dbReference type="GeneID" id="28765382"/>
    <dbReference type="InParanoid" id="A0A177CG69"/>
    <dbReference type="OrthoDB" id="5413827at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056632">
        <property type="entry name" value="DUF7730"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38790:SF4">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38790">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24864">
        <property type="entry name" value="DUF7730"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7730" evidence="2">
        <location>
            <begin position="236"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="431"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="443"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="467"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG06584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="495" mass="54554" checksum="D35D24B69FE84636" modified="2016-09-07" version="1">MAPKRTYNRHNMSIVKPDTDALIPSDPDNSCYEANKRRKPTPPSPANTMHHSDVMSSGGRPKSVNFKNAPSKPNHSNTKSFSGPTSLSNGEMDPFESVIKLAQETKAPQKQRSMSLYRGGHKAINSISAQLKSRRREGKKGDVAHILISDDSSSEGGIQLSESIELSPDDMDTTRMDSSSAMKATMRGGSESAAEASARIFGGREYTAPQTAPPRRTFCGARIKGNSVQAQAWSANQSSSPLLRLPASVRRSVFEYALGGNSIEFGFVTFLVDKTADGTKKYTPYFQYTSNVYPARPCEVQRNPFHGTPIRLHSNPDTTGMTLLNGVCRQLYLETYKLPYALNDFYFNSGNALFNFIVNDDRLQPQQLKSIKSIVVLHKLPVPSVLEKLPNLQQVRLMAPNLAIDIGFYKVVRDGKMPELVKFIPTSKNATGKLNRPGMRGGGGDDKKSDPKKAYLGAYGGKYGGSRSERGYGRDDTSWGYDSGKYKNKWSWGHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CGN5</accession>
    <name>A0A177CGN5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1259583</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG06381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036746.1">
        <property type="nucleotide sequence ID" value="XM_018184923.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CGN5"/>
    <dbReference type="STRING" id="1460663.A0A177CGN5"/>
    <dbReference type="GeneID" id="28768409"/>
    <dbReference type="InParanoid" id="A0A177CGN5"/>
    <dbReference type="OrthoDB" id="436496at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="241"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="408"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="301"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="420"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG06381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="434" mass="48788" checksum="2A339E7A09B646DB" modified="2016-09-07" version="1">MPVYRSISLKLHSQFDIETFPEYIPRPRSFYASRNIPVPVSASTPPFDDAATSTCSVYIRAFPASQFWLSYEVFPPVPADQHFLFKLFANGKHVVSWSTGREEGWKGKTMFALFEVEDESGRNRVEKRILCFPKGGGDEGGVKECFDEGRCLEVRVHRALGRKRVERELELYRETEHGRDEKGISLVNAGIAGSGHPKRFYKFALVDPVDKPYATFRYYYRTREQILGMGLSEDDVIKDSESDELSVIEPCSTNNKQSGEAGDENGMDIYARHDGAGDPPRSPHKTYISTESPRIRGGGSSKDHDERDAAPSRVGRGRTPSDYRLSVPPAYIFNPPQPSQRALQTLPQKRDPAADTSYQPHPVYPIDEWERKTPSPVQSLRKTISTPTFSRSTKSLLTPTGWFNAVAGAWRRRATPSSDDGSRTASRNDSRGVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CH16</accession>
    <name>A0A177CH16_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CC84DRAFT_1205639</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG05997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036362.1">
        <property type="nucleotide sequence ID" value="XM_018181989.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CH16"/>
    <dbReference type="STRING" id="1460663.A0A177CH16"/>
    <dbReference type="ESTHER" id="9pleo-a0a177ch16">
        <property type="family name" value="Fungal_carboxylesterase_lipase"/>
    </dbReference>
    <dbReference type="GeneID" id="28765475"/>
    <dbReference type="InParanoid" id="A0A177CH16"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007948966" description="Carboxylic ester hydrolase" evidence="3">
        <location>
            <begin position="21"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="27"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAG05997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="544" mass="60329" checksum="D1934B3FC0E712EE" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2023-06-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CH87</accession>
    <name>A0A177CH87_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_631060</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG06935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037300.1">
        <property type="nucleotide sequence ID" value="XM_018186947.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CH87"/>
    <dbReference type="GeneID" id="28770433"/>
    <dbReference type="InParanoid" id="A0A177CH87"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG06935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="106" mass="11928" checksum="5DFD596D59807D8A" modified="2016-09-07" version="1">MPLFEPGGGRTLQSRFKAEPKVWLMCRIEGHTCKGSIGQMMTVRGCPFVGLGKNKCTLDMRWHREALDLTDGRSNRKADVELTERVTCPHRSWTLGSHAKILLVCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CHF6</accession>
    <name>A0A177CHF6_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mitochondrial F1F0 ATP synthase-like protein subunit Atp18</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1258022</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG06756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037121.1">
        <property type="nucleotide sequence ID" value="XM_018184790.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CHF6"/>
    <dbReference type="FunCoup" id="A0A177CHF6">
        <property type="interactions" value="75"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CHF6"/>
    <dbReference type="GeneID" id="28768276"/>
    <dbReference type="InParanoid" id="A0A177CHF6"/>
    <dbReference type="OrthoDB" id="5520611at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006995">
        <property type="entry name" value="ATP_synth_F0_jsu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28060">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT J, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28060:SF1">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT J, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04911">
        <property type="entry name" value="ATP-synt_J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG06756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="61" mass="6680" checksum="1989EDCD74D5DE74" modified="2016-09-07" version="1">MPGFLGRKFPAPVAKPMWPFYVSGLVILYGVNAAAGAMMTADEYKEDPRNPLRKNPASDSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CHL4</accession>
    <name>A0A177CHL4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Large ribosomal subunit protein uL30m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CC84DRAFT_1163303</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uL30 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG07053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037418.1">
        <property type="nucleotide sequence ID" value="XM_018178229.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CHL4"/>
    <dbReference type="FunCoup" id="A0A177CHL4">
        <property type="interactions" value="155"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CHL4"/>
    <dbReference type="GeneID" id="28761715"/>
    <dbReference type="InParanoid" id="A0A177CHL4"/>
    <dbReference type="OrthoDB" id="509901at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01658">
        <property type="entry name" value="Ribosomal_L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1390.20:FF:000010">
        <property type="entry name" value="Large subunit ribosomal protein L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.20">
        <property type="entry name" value="Ribosomal protein L30, ferredoxin-like fold domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036919">
        <property type="entry name" value="Ribo_uL30_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005996">
        <property type="entry name" value="Ribosomal_uL30_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016082">
        <property type="entry name" value="Ribosomal_uL30_ferredoxin-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01308">
        <property type="entry name" value="rpmD_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15892:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL30M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15892">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOMAL PROTEIN L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00327">
        <property type="entry name" value="Ribosomal_L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55129">
        <property type="entry name" value="Ribosomal protein L30p/L7e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL30-like ferredoxin-like fold" evidence="8">
        <location>
            <begin position="4"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAG07053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="89" mass="10275" checksum="99C0E42E8ECA592B" modified="2016-09-07" version="1">MAYFRITLMRSGIGMPKKVQGVLHALGLKKRMTTVYYPVSQSVAGQIMRIKELVDVKEVEKPMSKEEMRAARRPDKGYYVEKRAEQVEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CIC3</accession>
    <name>A0A177CIC3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">UDP-Glycosyltransferase/glycogen phosphorylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CC84DRAFT_1090519</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG06537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036902.1">
        <property type="nucleotide sequence ID" value="XM_018174358.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CIC3"/>
    <dbReference type="STRING" id="1460663.A0A177CIC3"/>
    <dbReference type="GeneID" id="28757844"/>
    <dbReference type="InParanoid" id="A0A177CIC3"/>
    <dbReference type="OrthoDB" id="5835829at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016906">
        <property type="term" value="F:sterol 3-beta-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000100">
        <property type="entry name" value="Glycosyltransferase family 1 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000009">
        <property type="entry name" value="Sterol 3-beta-glucosyltransferase UGT80A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010610">
        <property type="entry name" value="EryCIII-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050426">
        <property type="entry name" value="Glycosyltransferase_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004276">
        <property type="entry name" value="GlycoTrans_28_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48050">
        <property type="entry name" value="STEROL 3-BETA-GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48050:SF5">
        <property type="entry name" value="UDP-GLUCOSE,STEROL TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06722">
        <property type="entry name" value="EryCIII-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03033">
        <property type="entry name" value="Glyco_transf_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyltransferase family 28 N-terminal" evidence="3">
        <location>
            <begin position="249"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="Erythromycin biosynthesis protein CIII-like C-terminal" evidence="4">
        <location>
            <begin position="566"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="821"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1004"/>
            <end position="1182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="128"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="169"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="821"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1018"/>
            <end position="1035"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1081"/>
            <end position="1096"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1142"/>
            <end position="1156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAG06537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="1182" mass="130961" checksum="266E174AEC36207F" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CIU8</accession>
    <name>A0A177CIU8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">WD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_1142762</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the WD repeat WDR6 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG06750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037115.1">
        <property type="nucleotide sequence ID" value="XM_018176379.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CIU8"/>
    <dbReference type="FunCoup" id="A0A177CIU8">
        <property type="interactions" value="591"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CIU8"/>
    <dbReference type="GeneID" id="28759865"/>
    <dbReference type="InParanoid" id="A0A177CIU8"/>
    <dbReference type="OrthoDB" id="5594999at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051973">
        <property type="entry name" value="tRNA_Anticodon_Mtase-Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14344">
        <property type="entry name" value="WD REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14344:SF3">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="3 7" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="222"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="848"/>
            <end position="882"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAG06750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="1175" mass="128563" checksum="2DD7421DD07345D2" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CJ05</accession>
    <name>A0A177CJ05_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative MFS monosaccharide transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CC84DRAFT_1163078</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG06767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037132.1">
        <property type="nucleotide sequence ID" value="XM_018178169.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CJ05"/>
    <dbReference type="GeneID" id="28761655"/>
    <dbReference type="InParanoid" id="A0A177CJ05"/>
    <dbReference type="OrthoDB" id="2544694at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF44">
        <property type="entry name" value="SUGAR TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14610)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="67"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="134"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="266"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="294"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="334"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="370"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="398"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="1"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAG06767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="486" mass="53423" checksum="BAD9C99D04534A98" modified="2016-09-07" version="1">MNIGADGVVTDSTKQGGLSAAYYFGAMFGAFIGGWIGDRYGRKVGVFAGAWQGVLGGALQAGSINSNMFICARVITGLGMGFVMAIVPPWVSELSQAHDRGSNFSFIFVANFLGITIANWLNFGVRNSEIEFRWRFPLGFMCIPVFTVAVTVMLLPESPRWLMAHDRRDEAVQILCKVRGDIEPTDPSIQQELEHLHAIVKASKHPRNSYVNLALGGRHSGVLHLGRRAILGFALQQIQQWSGIIAVVTWSSKLFSLAGFDEYKSLWMGGLVNTLGMFGTAAAGLVIDRIGRRMSLLVSFIIQGIALFIVAALIKSSENYAESDTGKSETLGQGAASFVFIYLWFFTMFNIVPCWLYGTEIWPQDVRAKGYSFTILGWAIGCGMTTFLIPIMLSKIGWYTFIFFGIMNAVTIPLIYLFYVEPAGHSLEEVNLLFTSDSPLVKHNNAEFDRRVAAAGGNSAVAARRLIEEVDGLVILEELKIEEAKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CJQ5</accession>
    <name>A0A177CJQ5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1175281</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG07481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037846.1">
        <property type="nucleotide sequence ID" value="XM_018180142.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CJQ5"/>
    <dbReference type="STRING" id="1460663.A0A177CJQ5"/>
    <dbReference type="GeneID" id="28763628"/>
    <dbReference type="InParanoid" id="A0A177CJQ5"/>
    <dbReference type="OrthoDB" id="4424523at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG07481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="224" mass="24636" checksum="2D282DDAA99B669E" modified="2016-09-07" version="1">MSDRCCHAAEGDVQQPDATAALGNTGLRLEGVKIFDDSLQQPRSSPNLLSRDAQLHLFSTSSHSRNLPIATAAPNSEPNPEHVLHEEKQAHSAEESTTARTVLWALAESAEVFTDLENSLHDSDLHPGAPWGFVVVRTVYGSFARMLEELTSNNRETLEDAQQGHVFLRHKLTILNNKATLNSADCHTVLRCFTHPHLSVGQFPDIKVVTINFWGGRAATIVED</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CKP0</accession>
    <name>A0A177CKP0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Opaque-specific ABC transporter CDR3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CC84DRAFT_1216703</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG07801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038166.1">
        <property type="nucleotide sequence ID" value="XM_018182835.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A177CKP0">
        <property type="interactions" value="353"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CKP0"/>
    <dbReference type="GeneID" id="28766321"/>
    <dbReference type="InParanoid" id="A0A177CKP0"/>
    <dbReference type="OrthoDB" id="245989at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03233">
        <property type="entry name" value="ABCG_PDR_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03232">
        <property type="entry name" value="ABCG_PDR_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:003632">
        <property type="entry name" value="ABC multidrug transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000054">
        <property type="entry name" value="ABC multidrug transporter atrF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029481">
        <property type="entry name" value="ABC_trans_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043926">
        <property type="entry name" value="ABCG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034001">
        <property type="entry name" value="ABCG_PDR_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034003">
        <property type="entry name" value="ABCG_PDR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010929">
        <property type="entry name" value="PDR_CDR_ABC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19241">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19055">
        <property type="entry name" value="ABC2_membrane_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14510">
        <property type="entry name" value="ABC_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06422">
        <property type="entry name" value="PDR_CDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="491"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="523"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="569"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="597"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="709"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1127"/>
            <end position="1147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1159"/>
            <end position="1178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1198"/>
            <end position="1228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1249"/>
            <end position="1270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1276"/>
            <end position="1297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1402"/>
            <end position="1420"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="128"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="788"/>
            <end position="1030"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="15"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="15"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="29"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OAG07801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="1432" mass="159653" checksum="B7C4015E98A96150" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CKW1</accession>
    <name>A0A177CKW1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Beta-galactosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CC84DRAFT_521928</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG07861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038226.1">
        <property type="nucleotide sequence ID" value="XM_018186612.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CKW1"/>
    <dbReference type="STRING" id="1460663.A0A177CKW1"/>
    <dbReference type="GeneID" id="28770098"/>
    <dbReference type="InParanoid" id="A0A177CKW1"/>
    <dbReference type="OrthoDB" id="1657402at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009341">
        <property type="term" value="C:beta-galactosidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004565">
        <property type="term" value="F:beta-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000135">
        <property type="entry name" value="Beta-galactosidase, putative, bgl35A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.220.20">
        <property type="entry name" value="putative beta-Galactosidase from caulobacter crescentus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040719">
        <property type="entry name" value="DUF5597"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013529">
        <property type="entry name" value="Glyco_hydro_42_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18120">
        <property type="entry name" value="DUF5597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02449">
        <property type="entry name" value="Glyco_hydro_42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase family 42 N-terminal" evidence="3">
        <location>
            <begin position="44"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="DUF5597" evidence="4">
        <location>
            <begin position="394"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF18120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAG07861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="561" mass="61940" checksum="34381521667E21FD" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CLD7</accession>
    <name>A0A177CLD7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF1996 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1195758</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG07670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038035.1">
        <property type="nucleotide sequence ID" value="XM_018181418.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CLD7"/>
    <dbReference type="STRING" id="1460663.A0A177CLD7"/>
    <dbReference type="GeneID" id="28764904"/>
    <dbReference type="InParanoid" id="A0A177CLD7"/>
    <dbReference type="OrthoDB" id="74764at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018535">
        <property type="entry name" value="DUF1996"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43662">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43662:SF13">
        <property type="entry name" value="DUF1996 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09362">
        <property type="entry name" value="DUF1996"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008058359" description="DUF1996 domain-containing protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1996" evidence="2">
        <location>
            <begin position="32"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG07670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="345" mass="39047" checksum="8CABBE8A2E36CEEC" modified="2016-09-07" version="1">MYWKSLLVLALAVPGRAIVRFHCSQLVRERLDPLVEPGANPSAHVHQIVGGNSFNATMEPGKDMPGESTCTTCTFADDFSNYWTAVMYFRAKNGTYKRVPNIGNNQFEKANGGLTIYYMQDAIYDENQKSNVTAFKPGFRMFIGDVHARTLAEASRYRYLTYTCLDTWTQRSPETIAFPQRKCKEGIMTTLRFPTCWDGKNLDSPDHMSHMSYPETGTFESGGPCPATHPVRTAQVMFEVLWDTKQFNDLEWPEDGRNPFVWSFGDATGYANHADYVFGWKDNSLQKVLDSPCYFYTNCSEYGHKLQSVEDMNKCAQKPVLEEDIDGWLDALPGGYQSQYGPTSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CLJ6</accession>
    <name>A0A177CLJ6_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein uL13m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_1162169</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uL13 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038541.1">
        <property type="nucleotide sequence ID" value="XM_018177928.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CLJ6"/>
    <dbReference type="FunCoup" id="A0A177CLJ6">
        <property type="interactions" value="711"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CLJ6"/>
    <dbReference type="GeneID" id="28761414"/>
    <dbReference type="InParanoid" id="A0A177CLJ6"/>
    <dbReference type="OrthoDB" id="274622at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017148">
        <property type="term" value="P:negative regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00392">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1180.10:FF:000007">
        <property type="entry name" value="50S ribosomal protein L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1180.10">
        <property type="entry name" value="Ribosomal protein L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01366">
        <property type="entry name" value="Ribosomal_uL13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005822">
        <property type="entry name" value="Ribosomal_uL13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005823">
        <property type="entry name" value="Ribosomal_uL13_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036899">
        <property type="entry name" value="Ribosomal_uL13_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01066">
        <property type="entry name" value="rplM_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11545:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL13M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11545">
        <property type="entry name" value="RIBOSOMAL PROTEIN L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00572">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002181">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52161">
        <property type="entry name" value="Ribosomal protein L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 8" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00068950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAG08176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="173" mass="19010" checksum="EA589578CE8DED12" modified="2016-09-07" version="1">MSQVVGKTRLAYARAWHHVDVASDERALGRLASSIAVTLMGKHKPIFDPSTDCGDYVVATNCEHIHVTGKKRAQKLYRTHTTRPGSLQEISLENLAAKWGGGEVLRRAVSGMLPKNRLRKGRLERLKTFEGEGNPYKQNFLKVSNGGGQGIIDFAQVKETLKAAKEDKVAPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2023-06-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CM33</accession>
    <name>A0A177CM33_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1174068</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038979.1">
        <property type="nucleotide sequence ID" value="XM_018180071.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CM33"/>
    <dbReference type="GeneID" id="28763557"/>
    <dbReference type="InParanoid" id="A0A177CM33"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG08614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="301" mass="33656" checksum="4EB0659286D08894" modified="2016-09-07" version="1">MATAAMVKAGVLKCIVMMICDPCGLQVLGISDFEKPNRWRKEADREMAIYAGQLEPLVSVNFVLMIAALPELNLGYNFVVTARRNAPITIKELDHQPRGSSVQILVLRHITLATVHLGGKSHSSGDLQFPRSRLAWHDLSRSPSMANFLGNSCHHGCMAPWSIKLSIKLSRGRLSSLPSSRRSSSKLSENTPELVLFGLLIAELRRISICPLYRHNACTMHGNIESQNISSLRSVSKADDYRVTSEMVNLVKGRRYKLLLTISNDRTVKQRVHGACDLDRDSRRRKDSGEKLELSDERVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CM61</accession>
    <name>A0A177CM61_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Mitochondrial carrier</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CC84DRAFT_1162534</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038990.1">
        <property type="nucleotide sequence ID" value="XM_018178018.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CM61"/>
    <dbReference type="STRING" id="1460663.A0A177CM61"/>
    <dbReference type="GeneID" id="28761504"/>
    <dbReference type="InParanoid" id="A0A177CM61"/>
    <dbReference type="OrthoDB" id="409948at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47567">
        <property type="entry name" value="MITOCHONDRIAL SUBSTRATE/SOLUTE CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47567:SF1">
        <property type="entry name" value="NAD-DEPENDENT EPIMERASE_DEHYDRATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="55"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="97"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="234"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="273"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="6">
        <location>
            <begin position="183"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAG08625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="370" mass="40483" checksum="B6ADA28E0BC97185" modified="2016-09-07" version="1">MASPHSLEAGREPNERSPLLSVDPLPEQQDASPDDSSDTASLKPQPEEPPSRYRLLWWALGIVLVEALLALFIQGWIESDDVDFDLGAALKRALGGGLSGAAAMVLQVLLLMPIRTIMNYQYRHGSSLSVATRTLYQDGGIRRYYQGIGAALFQGPIARFGDTAANAGILALLSSNGYLAQLPSPIKTIFASACAAAFRMTLTPIDTLKTTLQAQGAGGTALLRQRVKTDGIGSLWWGAFATAAATFVGHYPWFATYNWLSEVLNEPDRSHQLFLWLLRAAFIGFCASVVSDSISNSLRVIKTYRQVNDTKVSYSEAARRVIRQDGRLGLFGRGLKTRILANGLQGVMFSILWKLFLKIWENNTSSKKNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CN57</accession>
    <name>A0A177CN57_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1185642</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039308.1">
        <property type="nucleotide sequence ID" value="XM_018180814.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CN57"/>
    <dbReference type="STRING" id="1460663.A0A177CN57"/>
    <dbReference type="GeneID" id="28764300"/>
    <dbReference type="InParanoid" id="A0A177CN57"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF105">
        <property type="entry name" value="METHYLTRANSFERASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="44"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG08943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="386" mass="43565" checksum="E903865CC15B3CC9" modified="2016-09-07" version="1">MADPPRAPKNADAFSLHSTGHDSAVHVDDHREPHWTPPPPPAIPADVAAPAQALAQSDHGDDDDDENAPHEYVSDSGFDSESLLGDETDTLASSIMNYRIENGRQYHAYRDGAYWGPNDEVAKEILDFAHHMYLLTLDKKLHLAPIANPQRILDAGTGTGIWAIDMADQYPSATVVGTDLSPIQPEWVPPNCVFEIDDVTLDWTFPPNHFDFVHVRELFGCVPDWDFFFAQAYDHIAPGGWIEIVEHGVHPRCDDGTMGEDHFFHTWGKTVVGLSEKWGKSFTIWEEAKERLEKAGFVDVTEVTYKWPMNGWPTDRKMKDIGRWNQLRLHEGVESFMLRLLTQVGGWSVARAQLFLAQLRTELKNYKVHAYLPGTVVYGRKPLRST</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CNH6</accession>
    <name>A0A177CNH6_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Dolichol-phosphate mannosyltransferase subunit 1</fullName>
            <ecNumber evidence="13">2.4.1.83</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CC84DRAFT_1162414</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Transfers mannose from GDP-mannose to dolichol monophosphate to form dolichol phosphate mannose (Dol-P-Man) which is the mannosyl donor in pathways leading to N-glycosylation, glycosyl phosphatidylinositol membrane anchoring, and O-mannosylation of proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a di-trans,poly-cis-dolichyl phosphate + GDP-alpha-D-mannose = a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + GDP</text>
            <dbReference type="Rhea" id="RHEA:21184"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5 13">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Component of the dolichol-phosphate mannose (DPM) synthase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4 13">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 13">Belongs to the glycosyltransferase 2 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.83" evidence="13"/>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038833.1">
        <property type="nucleotide sequence ID" value="XM_018177990.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CNH6"/>
    <dbReference type="FunCoup" id="A0A177CNH6">
        <property type="interactions" value="849"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CNH6"/>
    <dbReference type="GeneID" id="28761476"/>
    <dbReference type="InParanoid" id="A0A177CNH6"/>
    <dbReference type="OrthoDB" id="2603at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004582">
        <property type="term" value="F:dolichyl-phosphate beta-D-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006066">
        <property type="term" value="P:alcohol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006720">
        <property type="term" value="P:isoprenoid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035269">
        <property type="term" value="P:protein O-linked glycosylation via mannose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06442">
        <property type="entry name" value="DPM1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000036">
        <property type="entry name" value="Dolichol-phosphate mannosyltransferase subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039528">
        <property type="entry name" value="DPM1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43398">
        <property type="entry name" value="DOLICHOL-PHOSPHATE MANNOSYLTRANSFERASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43398:SF1">
        <property type="entry name" value="DOLICHOL-PHOSPHATE MANNOSYLTRANSFERASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 13" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 13" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12" id="KW-0464">Manganese</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 13 15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="14">
        <location>
            <begin position="11"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00006739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU365083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OAG08468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="242" mass="27258" checksum="EAC199E7CDBCCE3B" modified="2016-09-07" version="1">MPPKQSKNKYSVLLPTYNERRNLPIITWLLNKTFTENDLDWELIIVDDGSPDGTQEVAAQLAKVYSPHIQIRARAGKLGLGTAYVHGLQFATGNFVIIMDADFSHHPKFIADMIRVQKEKNYDIVTGTRYAGNGGVFGWDLKRKFVSRGANLFADTVLRPGVSDLTGSFRLYKKEILEKVIRKTESKGYTFQMEMMVRAKAMGCTVAEVPISFVDRLYGESKLGGDEIVEYAKGVLNLWLKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CPG0</accession>
    <name>A0A177CPG0_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CC84DRAFT_1085036</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG09413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039778.1">
        <property type="nucleotide sequence ID" value="XM_018174081.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CPG0"/>
    <dbReference type="STRING" id="1460663.A0A177CPG0"/>
    <dbReference type="ESTHER" id="9pleo-a0a177cpg0">
        <property type="family name" value="Fungal_carboxylesterase_lipase"/>
    </dbReference>
    <dbReference type="GeneID" id="28757567"/>
    <dbReference type="InParanoid" id="A0A177CPG0"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050654">
        <property type="entry name" value="AChE-related_enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918">
        <property type="entry name" value="ACETYLCHOLINESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918:SF4">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007948967" description="Carboxylic ester hydrolase" evidence="3">
        <location>
            <begin position="19"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="28"/>
            <end position="543"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAG09413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="570" mass="62836" checksum="5CA58EFB07F972D7" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CPX5</accession>
    <name>A0A177CPX5_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NTF2-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1204154</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039305.1">
        <property type="nucleotide sequence ID" value="XM_018181886.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CPX5"/>
    <dbReference type="GeneID" id="28765372"/>
    <dbReference type="InParanoid" id="A0A177CPX5"/>
    <dbReference type="OrthoDB" id="3352776at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG08940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="291" mass="31192" checksum="EF7093570554CFB2" modified="2016-09-07" version="1">MVSLSTTAGDPLSARDGKSTCDTLCSPATAANPSPANAAYYTHYVNHVANPSAPHPKSHSQLTHPSLAPRSSLTATAPPYPNRSPNRPNVASHPLVSPSSAPTPPRIRQSRAALVPSPRPAPTGTRIRLLPTDGLLETQQQKPSAAALRKGAHAFCAALLSPPAPSELLQTYFTSTPRITEHGPRWAASRLPFLGKTFQGRDGCEEYFGLLGDVLEMQLPKDALPGPEGFIVDAEAGMVSVVGKGRFKSKKTGKGWDEQFIYRLSEFDAEGRFGHWEIWADPLSAWDAVGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CQ90</accession>
    <name>A0A177CQ90_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Actin binding protein-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CC84DRAFT_1162743</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039282.1">
        <property type="nucleotide sequence ID" value="XM_018178081.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CQ90"/>
    <dbReference type="FunCoup" id="A0A177CQ90">
        <property type="interactions" value="538"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CQ90"/>
    <dbReference type="GeneID" id="28761567"/>
    <dbReference type="InParanoid" id="A0A177CQ90"/>
    <dbReference type="OrthoDB" id="5971719at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005884">
        <property type="term" value="C:actin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030864">
        <property type="term" value="C:cortical actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030427">
        <property type="term" value="C:site of polarized growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030833">
        <property type="term" value="P:regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11281">
        <property type="entry name" value="ADF_drebrin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11962">
        <property type="entry name" value="SH3_Abp1_fungi_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11961">
        <property type="entry name" value="SH3_Abp1_fungi_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000242">
        <property type="entry name" value="Actin binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000273">
        <property type="entry name" value="Actin binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.20.10:FF:000045">
        <property type="entry name" value="Actin binding protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035719">
        <property type="entry name" value="Abp1_fungi_SH3_C1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035718">
        <property type="entry name" value="Abp1_fungi_SH3_C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002108">
        <property type="entry name" value="ADF-H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10829">
        <property type="entry name" value="CORTACTIN AND DREBRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10829:SF25">
        <property type="entry name" value="DREBRIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00241">
        <property type="entry name" value="Cofilin_ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00499">
        <property type="entry name" value="P67PHOX"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00102">
        <property type="entry name" value="ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51263">
        <property type="entry name" value="ADF_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="ADF-H" evidence="5">
        <location>
            <begin position="5"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="677"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="771"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="156"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="243"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="312"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="402"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="735"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="323"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="335"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="435"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="464"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="518"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="572"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="625"/>
            <end position="643"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAG08917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="829" mass="85788" checksum="447F713527BEE0DC" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CQU7</accession>
    <name>A0A177CQU7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1136869</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG09328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039693.1">
        <property type="nucleotide sequence ID" value="XM_018176118.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CQU7"/>
    <dbReference type="GeneID" id="28759604"/>
    <dbReference type="InParanoid" id="A0A177CQU7"/>
    <dbReference type="OrthoDB" id="2532623at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1050.10">
        <property type="entry name" value="At2g23090-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026939">
        <property type="entry name" value="ZNF706/At2g23090_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG09328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="79" mass="8876" checksum="32D10803ED3D0299" modified="2016-09-07" version="1">MPISKKARVQREHKAAEKAGTRAPVKANGLPVKAPKPTSICQNCRKEMVSTNKTQLMDHALTHDQKSWTKEKCFPNDFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CR55</accession>
    <name>A0A177CR55_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Glycosyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CC84DRAFT_1137121</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 15 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG09448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039813.1">
        <property type="nucleotide sequence ID" value="XM_018176134.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CR55"/>
    <dbReference type="FunCoup" id="A0A177CR55">
        <property type="interactions" value="38"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CR55"/>
    <dbReference type="GeneID" id="28759620"/>
    <dbReference type="InParanoid" id="A0A177CR55"/>
    <dbReference type="OrthoDB" id="439943at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000026">
        <property type="term" value="F:alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000032">
        <property type="term" value="P:cell wall mannoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002685">
        <property type="entry name" value="Glyco_trans_15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31121">
        <property type="entry name" value="ALPHA-1,2 MANNOSYLTRANSFERASE KTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31121:SF2">
        <property type="entry name" value="MANNOSYLTRANSFERASE KTR5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01793">
        <property type="entry name" value="Glyco_transf_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018153">
        <property type="entry name" value="Glyco_trans_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="52"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR018153-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAG09448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="519" mass="60221" checksum="6DF09B75483759BA" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CR98</accession>
    <name>A0A177CR98_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Halotolerance protein 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CC84DRAFT_1082606</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG09297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039662.1">
        <property type="nucleotide sequence ID" value="XM_018173989.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CR98"/>
    <dbReference type="FunCoup" id="A0A177CR98">
        <property type="interactions" value="121"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CR98"/>
    <dbReference type="GeneID" id="28757475"/>
    <dbReference type="InParanoid" id="A0A177CR98"/>
    <dbReference type="OrthoDB" id="6513151at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030003">
        <property type="term" value="P:intracellular monoatomic cation homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13994">
        <property type="entry name" value="STKc_HAL4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000183">
        <property type="entry name" value="Serine/threonine-protein kinase hal4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24343:SF558">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24343">
        <property type="entry name" value="SERINE/THREONINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 11" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="144"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="10"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00078109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OAG09297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="429" mass="48953" checksum="E2A52DFB896AA009" modified="2016-09-07" version="1">MTSRLSSMFTKRDESKEAQKAALVAEKNAEVKASNGAATRPQPSRQASVTGRTGGTTPPYRRFWVNDDGTHEHHLKVAKRQEKLSDMFQNLMLGKRKEGSHSDEQPLSLMANWVDVMRNEKEKLAEQKNSATSTTSQTLVQKYGKCQEVVGRGAFGIVRVAHKTDAKDPKREQLYAVKEFKQRPGESAKKYQKRLTAEFCISSSMQHPNVINTLDLLQDDKGTYCEVMEYCSGGDLYTLVLAAGQLEVVEADCFFKQLMRGVEYMHEMGVAHRDLKPENLLLTQHGSIKITDFGNGECFRMAWEKEAHMTAGLCGSAPYIAPEEYVDREFDPRAVDVWACGIIYMAMRTGRHLWRQAQKGEDEFFDRYLEDRKEEAGYRPIEVLRRRQCRNVIYSILDPNPTRRLTAHQVLFSEWVKEIKVCRAGDEGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CRS1</accession>
    <name>A0A177CRS1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1213276</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG09901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040266.1">
        <property type="nucleotide sequence ID" value="XM_018182517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CRS1"/>
    <dbReference type="GeneID" id="28766003"/>
    <dbReference type="InParanoid" id="A0A177CRS1"/>
    <dbReference type="OrthoDB" id="3781097at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG09901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="224" mass="24846" checksum="9AF60CC132920372" modified="2016-09-07" version="1">MERTPSIEDPYDVFAQLTADPYLSRLSPPPPTPHSARAPSSPPATPVAQIPQASRVPTPPLAAQPDRNLHPSHQRSEEHISPPAAQPNPNFLFTLQTIDPAHAPQNAKRYPKFSSAATAHTPFFSTIRRHVVAILHSRIPLSNEDIANPILDQAFAGPLTIRVWRLVYELVDLEGVAGNRDKENEVEKLKRRLVRELVGCVGWEAGIDEEWEAGRLVEGLWPRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CRU1</accession>
    <name>A0A177CRU1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">pyridoxal 5'-phosphate synthase</fullName>
            <ecNumber evidence="4">1.4.3.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CC84DRAFT_1213091</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor metabolism; pyridoxal 5'-phosphate salvage; pyridoxal 5'-phosphate from pyridoxamine 5'-phosphate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor metabolism; pyridoxal 5'-phosphate salvage; pyridoxal 5'-phosphate from pyridoxine 5'-phosphate: step 1/1.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.5" evidence="4"/>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG09688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040053.1">
        <property type="nucleotide sequence ID" value="XM_018182503.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CRU1"/>
    <dbReference type="FunCoup" id="A0A177CRU1">
        <property type="interactions" value="426"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CRU1"/>
    <dbReference type="GeneID" id="28765989"/>
    <dbReference type="InParanoid" id="A0A177CRU1"/>
    <dbReference type="OrthoDB" id="303614at2759"/>
    <dbReference type="UniPathway" id="UPA01068">
        <property type="reaction ID" value="UER00304"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004733">
        <property type="term" value="F:pyridoxamine phosphate oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008615">
        <property type="term" value="P:pyridoxine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01629">
        <property type="entry name" value="PdxH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000659">
        <property type="entry name" value="Pyridox_Oxase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019740">
        <property type="entry name" value="Pyridox_Oxase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019576">
        <property type="entry name" value="Pyridoxamine_oxidase_dimer_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00558">
        <property type="entry name" value="pdxH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004231">
        <property type="entry name" value="PRK05679.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10851:SF0">
        <property type="entry name" value="PYRIDOXINE-5'-PHOSPHATE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10851">
        <property type="entry name" value="PYRIDOXINE-5-PHOSPHATE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10590">
        <property type="entry name" value="PNP_phzG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="PNPOx_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000190">
        <property type="entry name" value="Pyd_amn-ph_oxd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01064">
        <property type="entry name" value="PYRIDOX_OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0288">FMN</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyridoxamine 5'-phosphate oxidase N-terminal" evidence="10">
        <location>
            <begin position="51"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="Pyridoxine 5'-phosphate oxidase dimerisation C-terminal" evidence="11">
        <location>
            <begin position="192"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="159"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF10590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OAG09688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="232" mass="26371" checksum="29FEE401535A0F97" modified="2016-09-07" version="1">MLHSAAPSNKRIFAPTGGSTDPGHAVQYKAGALNISDLAPTPTAQFHAWFNEALAAGVYQPETVTLATCSLPDGKPSARTVFMKELDDRGFVVYTNMGTSRKAADMASNPQAALTFWWREMERQVRVEGRTERLTSEESQVYYDTRIRGSRIGAWASPQSQVLEGREELERRVEEVEKRFDGQEKIPVPEFWGGVRVVPEVVEFWQGRESRLHDRLRYRREGEEWVVERLSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CS07</accession>
    <name>A0A177CS07_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Folylpolyglutamate synthase</fullName>
            <ecNumber evidence="17">6.3.2.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Folylpoly-gamma-glutamate synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Tetrahydrofolylpolyglutamate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">CC84DRAFT_1213652</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16 17">
            <text>(6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n) + L-glutamate + ATP = (6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n+1) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10580"/>
            <dbReference type="Rhea" id="RHEA-COMP:14738"/>
            <dbReference type="Rhea" id="RHEA-COMP:14740"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:141005"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="17">
            <name>a monovalent cation</name>
            <dbReference type="ChEBI" id="CHEBI:60242"/>
        </cofactor>
        <text evidence="17">A monovalent cation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 17">Cofactor biosynthesis; tetrahydrofolylpolyglutamate biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 17">Belongs to the folylpolyglutamate synthase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.17" evidence="17"/>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040678.1">
        <property type="nucleotide sequence ID" value="XM_018182559.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CS07"/>
    <dbReference type="FunCoup" id="A0A177CS07">
        <property type="interactions" value="675"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CS07"/>
    <dbReference type="GeneID" id="28766045"/>
    <dbReference type="InParanoid" id="A0A177CS07"/>
    <dbReference type="OrthoDB" id="5212574at2759"/>
    <dbReference type="UniPathway" id="UPA00850"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004326">
        <property type="term" value="F:tetrahydrofolylpolyglutamate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1190.10:FF:000009">
        <property type="entry name" value="Folylpolyglutamate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="entry name" value="Mur ligase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="entry name" value="Mur-like, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001645">
        <property type="entry name" value="Folylpolyglutamate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018109">
        <property type="entry name" value="Folylpolyglutamate_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023600">
        <property type="entry name" value="Folylpolyglutamate_synth_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01499">
        <property type="entry name" value="folC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11136:SF5">
        <property type="entry name" value="FOLYLPOLYGLUTAMATE SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11136">
        <property type="entry name" value="FOLYLPOLYGLUTAMATE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038895">
        <property type="entry name" value="FPGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="MurD-like peptide ligases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="MurD-like peptide ligases, peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01011">
        <property type="entry name" value="FOLYLPOLYGLU_SYNT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01012">
        <property type="entry name" value="FOLYLPOLYGLU_SYNT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 18" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 17" id="KW-0436">Ligase</keyword>
    <keyword evidence="13 19" id="KW-0460">Magnesium</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 19" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="10 18" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 17" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="19">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="327"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="341"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRNR" id="PIRNR038895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR038895-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR038895-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="OAG10313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="514" mass="55600" checksum="D35B17B6E5AB7599" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2023-06-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CTN8</accession>
    <name>A0A177CTN8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_497421</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041270.1">
        <property type="nucleotide sequence ID" value="XM_018186539.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CTN8"/>
    <dbReference type="GeneID" id="28770025"/>
    <dbReference type="InParanoid" id="A0A177CTN8"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG10905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="86" mass="9264" checksum="A98EB1D15CDA5697" modified="2016-09-07" version="1">MALASVMAARGPSYNDTSPLCLVVVLSQGQSQGCKILMFSGRFQVSCGRLKHLHSSLHVCKLQSRKVRLSSGSTLCGKLNTRENAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CU25</accession>
    <name>A0A177CU25_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">D-lactate dehydrogenase (cytochrome)</fullName>
            <ecNumber evidence="9">1.1.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CC84DRAFT_1161370</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(R)-lactate + 2 Fe(III)-[cytochrome c] = 2 Fe(II)-[cytochrome c] + pyruvate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:13521"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16004"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.1.2.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FAD-binding oxidoreductase/transferase type 4 family.</text>
    </comment>
    <dbReference type="EC" id="1.1.2.4" evidence="9"/>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040787.1">
        <property type="nucleotide sequence ID" value="XM_018177716.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CU25"/>
    <dbReference type="FunCoup" id="A0A177CU25">
        <property type="interactions" value="190"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CU25"/>
    <dbReference type="GeneID" id="28761202"/>
    <dbReference type="InParanoid" id="A0A177CU25"/>
    <dbReference type="OrthoDB" id="7786253at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004458">
        <property type="term" value="F:D-lactate dehydrogenase (cytochrome) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008720">
        <property type="term" value="F:D-lactate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903457">
        <property type="term" value="P:lactate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.465.10:FF:000014">
        <property type="entry name" value="D-lactate dehydrogenase (Cytochrome), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.45.10:FF:000001">
        <property type="entry name" value="D-lactate dehydrogenase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2740:FF:000001">
        <property type="entry name" value="D-lactate dehydrogenase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.45.10">
        <property type="entry name" value="Vanillyl-alcohol Oxidase, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004113">
        <property type="entry name" value="FAD-bd_oxidored_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016164">
        <property type="entry name" value="FAD-linked_Oxase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016171">
        <property type="entry name" value="Vanillyl_alc_oxidase_C-sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11748">
        <property type="entry name" value="D-LACTATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11748:SF111">
        <property type="entry name" value="D-LACTATE DEHYDROGENASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02913">
        <property type="entry name" value="FAD-oxidase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55103">
        <property type="entry name" value="FAD-linked oxidases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="11">
        <location>
            <begin position="127"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00051436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OAG10422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="553" mass="60593" checksum="0EB33556D597F8A5" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CUQ9</accession>
    <name>A0A177CUQ9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Bacterial collagen-like protein middle domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1237488</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040975.1">
        <property type="nucleotide sequence ID" value="XM_018183900.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CUQ9"/>
    <dbReference type="STRING" id="1460663.A0A177CUQ9"/>
    <dbReference type="GeneID" id="28767386"/>
    <dbReference type="InParanoid" id="A0A177CUQ9"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.20">
        <property type="entry name" value="Apolipoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008058609" description="Bacterial collagen-like protein middle domain-containing protein" evidence="2">
        <location>
            <begin position="19"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="328"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="328"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="344"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG10610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="353" mass="31680" checksum="B8A0A81FCB12F451" modified="2016-09-07" version="1">MKVFASAAALFAIPLVAGAPIESKRQVDQLLQGVTGAAGNLVGGVTGAAGDVVGGVTGAAGNVVNGVGNTAGGVVAGVTGAADDVVRGATGAAGGVAGGVTSAAGDVVDGIKNTTGDVLSGVTGTAGQAVGDVTGTAGNLVSGLTGTAGNAAKGVGNTAGAATQGTGGLLSGLLGRDVKDLTEVEKRQLDSLLGGVTSTVGDLTGTVGNLAGGVTGGLTGGSNANAQGGAAQGAGAGSSGGLLSGLLGRDVEELSEVERRQLDGLLSGLTGTVGDLTGSLLGGLTGGNGGNAAAVTGANGDSSGAADASGAGGVGNLLSGLTGSLTGSGANAGSTQGTAGTGTSGASNASAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2023-06-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CVN0</accession>
    <name>A0A177CVN0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_500923</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041317.1">
        <property type="nucleotide sequence ID" value="XM_018186556.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CVN0"/>
    <dbReference type="GeneID" id="28770042"/>
    <dbReference type="InParanoid" id="A0A177CVN0"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG10952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="179" mass="19722" checksum="FCB17B814BEB62A9" modified="2016-09-07" version="1">MRREGKDRKQTKPCHARTLQILRRGQGQATVAASRRSWVQKRRCGGEDGVPRTQKSLAGWPAPLDEASCSVPDYAQNCGLSKCRNLAVIIDNGRLDERCLKRCYHVGLSCMPPAMCSACVHPPEPQARLVSPRCTLDLIIPTQIMREVWDAALGGAAGLTRSIWQSMRSTPKISVVGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CVV0</accession>
    <name>A0A177CVV0_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">xylan 1,4-beta-xylosidase</fullName>
            <ecNumber evidence="11">3.2.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CC84DRAFT_1139713</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>Hydrolysis of (1-&gt;4)-beta-D-xylans, to remove successive D-xylose residues from the non-reducing termini.</text>
            <dbReference type="EC" id="3.2.1.37"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Glycan degradation; xylan degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.37" evidence="11"/>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041214.1">
        <property type="nucleotide sequence ID" value="XM_018176251.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CVV0"/>
    <dbReference type="STRING" id="1460663.A0A177CVV0"/>
    <dbReference type="GeneID" id="28759737"/>
    <dbReference type="InParanoid" id="A0A177CVV0"/>
    <dbReference type="OrthoDB" id="47059at2759"/>
    <dbReference type="UniPathway" id="UPA00114"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046556">
        <property type="term" value="F:alpha-L-arabinofuranosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009044">
        <property type="term" value="F:xylan 1,4-beta-xylosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031222">
        <property type="term" value="P:arabinan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044993">
        <property type="entry name" value="BXL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42721:SF3">
        <property type="entry name" value="BETA-D-XYLOSIDASE 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42721">
        <property type="entry name" value="SUGAR HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="Beta-D-glucan exohydrolase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0858">Xylan degradation</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008058712" description="xylan 1,4-beta-xylosidase" evidence="12">
        <location>
            <begin position="20"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type III-like" evidence="13">
        <location>
            <begin position="674"/>
            <end position="744"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00026107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OAG10849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="774" mass="84509" checksum="A2FA7E75A78FFE49" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CVZ0</accession>
    <name>A0A177CVZ0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1214177</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041254.1">
        <property type="nucleotide sequence ID" value="XM_018182609.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CVZ0"/>
    <dbReference type="GeneID" id="28766095"/>
    <dbReference type="InParanoid" id="A0A177CVZ0"/>
    <dbReference type="OrthoDB" id="5130616at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG10889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="347" mass="39498" checksum="21A3A41C26B82FEE" modified="2016-09-07" version="1">MFIGLAQHLLPNLREIAIVEDAKHERNRQFSHSVFFDLPELESVFVYNFEALEGDRDLHFRQLEMNNLIYMNHVMTSIRSRLDETSSRYCPDITIPHLEVSDAYLDSFSLVDLIYAFPALRTFAFDFRKSAIPEHPRFFNALISVLSTRAETLTALSIGGHPDDCHETATPIDFSSLGNLNHLRISISVFLGSKSGAQSLTDDRMRERFPASLQKLVLLVYKSEEHHILPPLQHYIDAEPPIIPNLKELEVCCHAPEAMHGWLQGAAERHGINLRIFRKLKTSQEDLSIVPFVNTVKGTKQEISQVKITITPPVSNLLLEELMPLEEYMPDTEIVVPIFEEASMHAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CW16</accession>
    <name>A0A177CW16_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="18">CFEM domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CC84DRAFT_1106926</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the RBT5 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG11426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041791.1">
        <property type="nucleotide sequence ID" value="XM_018175158.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CW16"/>
    <dbReference type="STRING" id="1460663.A0A177CW16"/>
    <dbReference type="GeneID" id="28758644"/>
    <dbReference type="InParanoid" id="A0A177CW16"/>
    <dbReference type="OrthoDB" id="2496787at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008427">
        <property type="entry name" value="Extracellular_membr_CFEM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF143">
        <property type="entry name" value="EXTRACELLULAR MEMBRANE PROTEIN CFEM DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05730">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00747">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52012">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="14" id="KW-0349">Heme</keyword>
    <keyword evidence="14" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="10 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="8 16" id="KW-0732">Signal</keyword>
    <keyword evidence="7 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008058664" evidence="16">
        <location>
            <begin position="21"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="138"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="179"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="214"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="297"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="342"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="domain" description="CFEM" evidence="17">
        <location>
            <begin position="6"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="14">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="34"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="38"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="48"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="57"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS52012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="OAG11426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="431" mass="47738" checksum="5C04DF83DC1564F3" modified="2016-09-07" version="1">MRAPIAILTLLLLSLPFSIAQGTLTEAIEQLPACALKCLVSAISESPCQLTDQTCICTNQKLQLDVEVCVLQACSKKEALTTKNITSTSCGAPIRDSSALYCTISTTLAVLSAALVLLRLGYKMFITSMELGLDDCFVFITLLAGTPSSAINVLGLAANGLGKDVWTLRFNQITSFSKYFYIMEIMYFAQITLLKLSLLFFYLRVFPGKPVRRVIWATVIFNSLFGAVFVTVAIFQCRPISHYWNEWHGETPGTCININALGWSNAAISIALDFWMLAIPISQLLDLQLAWKKKVGVALMFCVGTFVTVVSILRLHSLVHFAKSINPTWDYWAVSNWSTVEINVGIMCVCMPSLRIILVRFFPKVLGTMRSNTGGYARYGSSSRIERVKIGNSNASTGHDKGMEDDVEMIIREAPSVDDSRSDVYKSRVYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CWV2</accession>
    <name>A0A177CWV2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1170835</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042390.1">
        <property type="nucleotide sequence ID" value="XM_018179878.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CWV2"/>
    <dbReference type="STRING" id="1460663.A0A177CWV2"/>
    <dbReference type="GeneID" id="28763364"/>
    <dbReference type="InParanoid" id="A0A177CWV2"/>
    <dbReference type="OrthoDB" id="66095at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG12025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="183" mass="20866" checksum="A7AAA6049989C0AF" modified="2016-09-07" version="1">MDAYAISRSDVFDVRALLAAKRLPNELVLAILDHARYWVEVRHEKAVLDALVHDEHSLEFSAAYPYMVIPTTTSTHGPSSEVSKLREIEIILVSHDQGWSTTGTRHTYQQSSSFWEASILRPIANDDVNHVPRLMTKFEEDRSRNGNYRSVESAAQAITPENCTICYVDLTRTWNRSDFTVAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CWV5</accession>
    <name>A0A177CWV5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Metallo-hydrolase/oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CC84DRAFT_1223990</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-beta-lactamase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG11209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041574.1">
        <property type="nucleotide sequence ID" value="XM_018183534.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CWV5"/>
    <dbReference type="STRING" id="1460663.A0A177CWV5"/>
    <dbReference type="GeneID" id="28767020"/>
    <dbReference type="InParanoid" id="A0A177CWV5"/>
    <dbReference type="OrthoDB" id="10250730at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07730">
        <property type="entry name" value="metallo-hydrolase-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051013">
        <property type="entry name" value="MBL_superfamily_lactonases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42978:SF5">
        <property type="entry name" value="METALLO-BETA-LACTAMASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42978">
        <property type="entry name" value="QUORUM-QUENCHING LACTONASE YTNP-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="5">
        <location>
            <begin position="57"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAG11209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="354" mass="39075" checksum="41390A20773F1ABC" modified="2016-09-07" version="1">MSRPVSSARAVTAPPVGIPPSPNTVDVRVIDTQTLLHLNPSLFWQPSLGGFDGLDAPVYCFLITHGNEHVIFDLGVRTDWENYPPKIVSLIKATTRVEPGQDVASVINGSHITRSSEVSAVILSHNHFDHIGDIGTIPNAEIIVGPGVRNTLFPGWPQDPDGPLKSEDLHGRVIREIAFDEDLKIGRFDAVDLFQDGSFFLLDAPGHAIGHMCALARTTPDSFIFMGADACHHPGVLRPTKYLTLPKPTHESLLGQCPGDVLERIRGSELSPCSPFFTVANGPLFPDREAAVSTVEKIHELDACEDVFVILGHDNSLRDRIPMFPEKINDWKSTDVRPETRWLFCEDFKNVRFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CX66</accession>
    <name>A0A177CX66_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">3-hydroxyisobutyrate dehydrogenase</fullName>
            <ecNumber evidence="3">1.1.1.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CC84DRAFT_1224900</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>3-hydroxy-2-methylpropanoate + NAD(+) = 2-methyl-3-oxopropanoate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17681"/>
            <dbReference type="ChEBI" id="CHEBI:11805"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57700"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.31"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid degradation; L-valine degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HIBADH-related family. 3-hydroxyisobutyrate dehydrogenase subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.31" evidence="3"/>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG11638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042003.1">
        <property type="nucleotide sequence ID" value="XM_018183552.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CX66"/>
    <dbReference type="STRING" id="1460663.A0A177CX66"/>
    <dbReference type="GeneID" id="28767038"/>
    <dbReference type="InParanoid" id="A0A177CX66"/>
    <dbReference type="OrthoDB" id="21615at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008442">
        <property type="term" value="F:3-hydroxyisobutyrate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006574">
        <property type="term" value="P:L-valine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000006">
        <property type="entry name" value="3-hydroxyisobutyrate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000746">
        <property type="entry name" value="3-hydroxyisobutyrate dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029154">
        <property type="entry name" value="HIBADH-like_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015815">
        <property type="entry name" value="HIBADH-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22981">
        <property type="entry name" value="3-HYDROXYISOBUTYRATE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22981:SF81">
        <property type="entry name" value="DEHYDROGENASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14833">
        <property type="entry name" value="NAD_binding_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000103">
        <property type="entry name" value="HIBADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0101">Branched-chain amino acid catabolism</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6-phosphogluconate dehydrogenase NADP-binding" evidence="9">
        <location>
            <begin position="8"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="3-hydroxyisobutyrate dehydrogenase-like NAD-binding" evidence="10">
        <location>
            <begin position="183"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000103-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF14833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OAG11638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="322" mass="34641" checksum="B18C9471DE2F141E" modified="2016-09-07" version="1">MGESEFKKLGFVGLGAMGKPMLVHLANKLPKESRIYVYDVVEDAMNEVCSKYPERVLRASSAKDVAHQADTIITMVPEGSHVRSVYLDPSHGVCSADISNKLLIDCSTIDTATSLEVKEHIEKHFPTASFYDSPVSGGVVGAIKGTIAFFLGCAESDPNIKRLTPLMEMMGKQVIPCGGPSLGLAAKLSNNYLSGVIAIACSEAFDMGMRSGLDPRTLAKVYAAGTAQNAICDRFCPVPHVYPEAPSSGGYKQGFKVQLMRKDFGLAVDMAKRVGSKNVLGEVGLETYDGASKDPNCRDLDSRVVYRYLGGNEDWQPTKNGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CXB0</accession>
    <name>A0A177CXB0_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cip1-like core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1077474</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG11467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041832.1">
        <property type="nucleotide sequence ID" value="XM_018173754.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CXB0"/>
    <dbReference type="STRING" id="1460663.A0A177CXB0"/>
    <dbReference type="GeneID" id="28757240"/>
    <dbReference type="InParanoid" id="A0A177CXB0"/>
    <dbReference type="OrthoDB" id="5313668at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048955">
        <property type="entry name" value="Cip1-like_core"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21340">
        <property type="entry name" value="Polysacc_lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008058705" description="Cip1-like core domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="Cip1-like core" evidence="2">
        <location>
            <begin position="23"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG11467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="234" mass="24809" checksum="98D339AC40049F05" modified="2016-09-07" version="1">MLRQIALVALAALPGSLAQVTEGFENGWDQTAWPTYALDCSQGGSVALDTTTAHSGKNSIKVTGAGGYCGHIFVGTTKVPSSGDVYVRTWLKASKALTDSHVSFITMPDSAQGSKKHLRIGGQSKILMYNRESDDATLPDLSPNGIAASKALPTGSWQCFEYHLGADGSIETWLNGEAIAGLTTKNNSNAGQWTRSSIKPKITGVYFGWESYGGDTNTFNYDDIAIGSTRIGCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CYM3</accession>
    <name>A0A177CYM3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_113980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042731.1">
        <property type="nucleotide sequence ID" value="XM_018176256.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CYM3"/>
    <dbReference type="STRING" id="1460663.A0A177CYM3"/>
    <dbReference type="GeneID" id="28759742"/>
    <dbReference type="InParanoid" id="A0A177CYM3"/>
    <dbReference type="OrthoDB" id="372487at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="59"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="85"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG12366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="232" mass="24212" checksum="6D352CE56B23740A" modified="2016-09-07" version="1">MPKIEAKTAHKSVLLKGVDMPTKMLNENDETNVRRQQNGRGGFRGGRGGGRGDYHSHNNQRSGGDNYNNNNRGGYGNDRGGRGGYNNNRGGYNSVGRGGYNSFQPPAGYPPPPFPIPGMNGLPPPPPGWVPPPPPGLEAWGGNGRPPVQHPVGQQHWAPPPQHAPQGSSLPNYRPANEILGHNGGGRGGGGYNNGGQQRGGRGGGGRGGYGGGGHNNGGGQQGNGYNNHRRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177D081</accession>
    <name>A0A177D081_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Eukaryotic translation initiation factor 2-alpha kinase-like protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CC84DRAFT_128809</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042937.1">
        <property type="nucleotide sequence ID" value="XM_018185363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177D081"/>
    <dbReference type="STRING" id="1460663.A0A177D081"/>
    <dbReference type="GeneID" id="28768849"/>
    <dbReference type="InParanoid" id="A0A177D081"/>
    <dbReference type="OrthoDB" id="1405469at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004694">
        <property type="term" value="F:eukaryotic translation initiation factor 2alpha kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050339">
        <property type="entry name" value="CC_SR_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042:SF187">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE EIF2-ALPHA KINASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="224"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="363"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="22"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="35"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="380"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="393"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="253"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAG12572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="675" mass="74186" checksum="EA251ABAD1FE4BB4" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177D0C8</accession>
    <name>A0A177D0C8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein kinase-like protein Scy1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1192780</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018043052.1">
        <property type="nucleotide sequence ID" value="XM_018181258.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177D0C8"/>
    <dbReference type="FunCoup" id="A0A177D0C8">
        <property type="interactions" value="772"/>
    </dbReference>
    <dbReference type="GeneID" id="28764744"/>
    <dbReference type="InParanoid" id="A0A177D0C8"/>
    <dbReference type="OrthoDB" id="79687at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14011">
        <property type="entry name" value="PK_SCY1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051177">
        <property type="entry name" value="CIK-Related_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12984:SF6">
        <property type="entry name" value="SCY1-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12984">
        <property type="entry name" value="SCY1-RELATED S/T PROTEIN KINASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="23"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="736"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="835"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="736"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="836"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="857"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="873"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="884"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="941"/>
            <end position="955"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG12687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="979" mass="105108" checksum="1A3B381B38267657" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177D0E5</accession>
    <name>A0A177D0E5_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Translation machinery-associated protein 20</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CC84DRAFT_1160121</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Involved in translation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TMA20 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018043233.1">
        <property type="nucleotide sequence ID" value="XM_018177415.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177D0E5"/>
    <dbReference type="FunCoup" id="A0A177D0E5">
        <property type="interactions" value="543"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177D0E5"/>
    <dbReference type="GeneID" id="28760901"/>
    <dbReference type="InParanoid" id="A0A177D0E5"/>
    <dbReference type="OrthoDB" id="10249667at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001731">
        <property type="term" value="P:formation of translation preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd11609">
        <property type="entry name" value="MCT1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21155">
        <property type="entry name" value="PUA_MCTS-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.400.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016437">
        <property type="entry name" value="MCT-1/Tma20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041366">
        <property type="entry name" value="Pre-PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002478">
        <property type="entry name" value="PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004521">
        <property type="entry name" value="Uncharacterised_CHP00451"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00451">
        <property type="entry name" value="unchar_dom_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22798:SF0">
        <property type="entry name" value="MALIGNANT T-CELL-AMPLIFIED SEQUENCE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22798">
        <property type="entry name" value="MCT-1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17832">
        <property type="entry name" value="Pre-PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01472">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005067">
        <property type="entry name" value="Tma_RNA-bind_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00359">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50890">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PUA" evidence="4">
        <location>
            <begin position="90"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR005067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAG12868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="189" mass="20887" checksum="2B393CB5E1D1C39E" modified="2016-09-07" version="1">MFKKDITSGAKSKVKSSVQRTIRQKVLDTYPLLEPYIEDIMPKKEQLDLVKLPDRVSLYTLQSTPLFFQHMDDAILPHLAIVHRYPNCFPRLRIDRGAIRFVLSGATLMAPGLTSPGGRLPGDPEDTEGKYGKEELEAGTPVVIEAEGKEMACMVGVLKVGTAEMKKTKKGQACEAGHYLGDGLWTLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177D0K1</accession>
    <name>A0A177D0K1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CC84DRAFT_1136124</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018043313.1">
        <property type="nucleotide sequence ID" value="XM_018176088.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177D0K1"/>
    <dbReference type="STRING" id="1460663.A0A177D0K1"/>
    <dbReference type="GeneID" id="28759574"/>
    <dbReference type="InParanoid" id="A0A177D0K1"/>
    <dbReference type="OrthoDB" id="7130006at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004301">
        <property type="term" value="F:epoxide hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097176">
        <property type="term" value="P:epoxide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010497">
        <property type="entry name" value="Epoxide_hydro_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016292">
        <property type="entry name" value="Epoxide_hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21661:SF35">
        <property type="entry name" value="EPOXIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21661">
        <property type="entry name" value="EPOXIDE HYDROLASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06441">
        <property type="entry name" value="EHN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001112">
        <property type="entry name" value="Epoxide_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0058">Aromatic hydrocarbons catabolism</keyword>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epoxide hydrolase N-terminal" evidence="5">
        <location>
            <begin position="5"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="179"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="312"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR001112-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF06441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAG12948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="406" mass="46132" checksum="CE640A6FBC59AF80" modified="2016-09-07" version="1">MSSPEPYKIHVPDASIEKLKRRLEDTDYPDELEIDDQWRYGAPTSDVKRLAEHWRTGFDWRKTEAEINELPNYRKKVSVDGFGDIDLHFVWQKSEVEGAIPLLFSHGWPGSFLEVMKLLPLLKGDGDSPAFHIVAPSLPNFGFSQRITKPGFALEQYAQTCHRLMLDLGYPKYITQGGDWGFYITRTMGLLYPNAVLASHINMIRAHAPSFASQPALALQHALTPYSDAEKKGLERSEWFTSEGQAYRQLQATKPQTLSYAFASSPVALLAWIYEKLVDWTDGYPWTDDEILTWVSIYYFSTAGPNAHIRIYYEASHNPTAAVPSRERLSEWIGRVKLGLAHFPREITVVPRVWGKTLGNVVHESVNERGGHFAAWERPDVISKDLRDMFGKKGPLYNVVPGKSGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177D0X3</accession>
    <name>A0A177D0X3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1079342</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018043252.1">
        <property type="nucleotide sequence ID" value="XM_018173843.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177D0X3"/>
    <dbReference type="GeneID" id="28757329"/>
    <dbReference type="InParanoid" id="A0A177D0X3"/>
    <dbReference type="OrthoDB" id="2157103at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG12887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="62" mass="7020" checksum="373792C2301B96AB" modified="2016-09-07" version="1" fragment="single">DQPTKTDEQKTKPKKTQAELDKELQLKMQGLSGDGGESGVEYEDGQPVSMKRSVKDNMFRYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177D1R2</accession>
    <name>A0A177D1R2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1212619</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG13177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018043542.1">
        <property type="nucleotide sequence ID" value="XM_018182467.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177D1R2"/>
    <dbReference type="GeneID" id="28765953"/>
    <dbReference type="InParanoid" id="A0A177D1R2"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG13177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="223" mass="25729" checksum="5BC0A8A6C15AF6F7" modified="2016-09-07" version="1">MVEKYITTVWDAYGMRDTSFEARAQLRYMVLESTALSNKTLSFSPDEIPTQGKDLFCILLNRHVNRKSDVDHETVAFNEPLLNFNVEDHGIVCESVDQSIRRFRRVGFFKEYMSVDNRFLRALSGEYEGKVPMFDKSRADGRMYFKSDILNHLGFHRHGDEAPVSSLSTVDAETGVRMLGFKLSDFGDRERSLEKIVPQDLVKVDGKLSLFRDGYEEVEMEIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BTK5</accession>
    <name>A0A177BTK5_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cell division control protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CC84DRAFT_422443</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the CDC6/cdc18 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441564">
        <property type="protein sequence ID" value="OAF98733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029099.1">
        <property type="nucleotide sequence ID" value="XM_018186164.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BTK5"/>
    <dbReference type="FunCoup" id="A0A177BTK5">
        <property type="interactions" value="1051"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177BTK5"/>
    <dbReference type="GeneID" id="28769650"/>
    <dbReference type="InParanoid" id="A0A177BTK5"/>
    <dbReference type="OrthoDB" id="1926878at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033314">
        <property type="term" value="P:mitotic DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000547">
        <property type="entry name" value="Cell division control protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016314">
        <property type="entry name" value="Cdc6/18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015163">
        <property type="entry name" value="Cdc6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054425">
        <property type="entry name" value="Cdc6_ORC1-like_ATPase_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050311">
        <property type="entry name" value="ORC1/CDC6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10763:SF26">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 6 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10763">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22606">
        <property type="entry name" value="Cdc6-ORC-like_ATPase_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09079">
        <property type="entry name" value="WHD_Cdc6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001767">
        <property type="entry name" value="Cdc6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3 12" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Orc1-like AAA ATPase" evidence="10">
        <location>
            <begin position="185"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="Cdc6/ORC1-like ATPase lid" evidence="11">
        <location>
            <begin position="354"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="domain" description="Cdc6 C-terminal" evidence="9">
        <location>
            <begin position="501"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="73"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="92"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR001767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF09079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF22606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OAF98733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="650" mass="69858" checksum="1DBD929E73BE82DC" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BVJ8</accession>
    <name>A0A177BVJ8_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phosphoribosylglycinamide formyltransferase</fullName>
            <ecNumber evidence="2">2.1.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">5'-phosphoribosylglycinamide transformylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">GAR transformylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CC84DRAFT_1104451</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>N(1)-(5-phospho-beta-D-ribosyl)glycinamide + (6R)-10-formyltetrahydrofolate = N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide + (6S)-5,6,7,8-tetrahydrofolate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15053"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:143788"/>
            <dbReference type="ChEBI" id="CHEBI:147286"/>
            <dbReference type="ChEBI" id="CHEBI:195366"/>
            <dbReference type="EC" id="2.1.2.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; IMP biosynthesis via de novo pathway; N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide from N(1)-(5-phospho-D-ribosyl)glycinamide (10-formyl THF route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the GART family.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.2" evidence="2"/>
    <dbReference type="EMBL" id="KV441562">
        <property type="protein sequence ID" value="OAF99422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029788.1">
        <property type="nucleotide sequence ID" value="XM_018175058.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BVJ8"/>
    <dbReference type="FunCoup" id="A0A177BVJ8">
        <property type="interactions" value="202"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177BVJ8"/>
    <dbReference type="GeneID" id="28758544"/>
    <dbReference type="InParanoid" id="A0A177BVJ8"/>
    <dbReference type="OrthoDB" id="5575075at2759"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00126"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004644">
        <property type="term" value="F:phosphoribosylglycinamide formyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046084">
        <property type="term" value="P:adenine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd08645">
        <property type="entry name" value="FMT_core_GART"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.170:FF:000009">
        <property type="entry name" value="Phosphoribosylglycinamide formyltransferase (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.170">
        <property type="entry name" value="Formyl transferase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01930">
        <property type="entry name" value="PurN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002376">
        <property type="entry name" value="Formyl_transf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036477">
        <property type="entry name" value="Formyl_transf_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004607">
        <property type="entry name" value="GART"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001555">
        <property type="entry name" value="GART_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00639">
        <property type="entry name" value="PurN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43369">
        <property type="entry name" value="PHOSPHORIBOSYLGLYCINAMIDE FORMYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43369:SF2">
        <property type="entry name" value="PHOSPHORIBOSYLGLYCINAMIDE FORMYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00551">
        <property type="entry name" value="Formyl_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53328">
        <property type="entry name" value="Formyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00373">
        <property type="entry name" value="GART"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Formyl transferase N-terminal" evidence="10">
        <location>
            <begin position="7"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00041324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00041682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OAF99422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="217" mass="23333" checksum="7AA3AF170D6BE58C" modified="2016-09-07" version="1">MSQSPYNLVVLISGNGSNLQALIDASGTPALPNTRITHVISNRKAAYGLERAAKASIPTTYHNLVPFKRKHPQTEAGTTAARTEYDASLAALILGLEPRPDVIVCAGWMHILTPDFLNPIAAAGVKVINLHPALPGEFAGAGAIERAWEAGRSEGLKRTGVMIHEVIAEVDAGEAIVTREVELREGESLDELETRIHEVEHGLIVEGTRRTLEGIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BW48</accession>
    <name>A0A177BW48_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF1295-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1169637</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441563">
        <property type="protein sequence ID" value="OAF98888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029254.1">
        <property type="nucleotide sequence ID" value="XM_018179709.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BW48"/>
    <dbReference type="GeneID" id="28763195"/>
    <dbReference type="InParanoid" id="A0A177BW48"/>
    <dbReference type="OrthoDB" id="67965at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010721">
        <property type="entry name" value="UstE-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32251">
        <property type="entry name" value="3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32251:SF15">
        <property type="entry name" value="3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE (DUF1295)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06966">
        <property type="entry name" value="DUF1295"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50244">
        <property type="entry name" value="S5A_REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="32"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="153"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="238"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="249"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAF98888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="263" mass="30141" checksum="C22C3576B73597A5" modified="2016-09-07" version="1">MMAWAARLSGFLLFRILKTGKDDRFDDKRDKFWSFLGFWVFQMFWVWTCSLPVTILNSPKVTQFPQPSFGTGCDIAGIVLFAIGFIMESVSDVQKYRFRSAHGSDGEVCDVGFFAWTRHPNYFGEIMIQFAIFTIAVAPAANKYVRGGPYAALYASILGPIFLTSLLMFLSGLPLQERPGAKKRYEKGIKWPEYERYLRRTSILIPFPPQLYEKMPVILKRTVFLEFPIYVFDPAKHADQSKVQPNNAEEGRARPSDEEGLRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BWT8</accession>
    <name>A0A177BWT8_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CC84DRAFT_1190705</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ERT1/acuK family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441560">
        <property type="protein sequence ID" value="OAF99862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030228.1">
        <property type="nucleotide sequence ID" value="XM_018181132.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BWT8"/>
    <dbReference type="STRING" id="1460663.A0A177BWT8"/>
    <dbReference type="GeneID" id="28764618"/>
    <dbReference type="InParanoid" id="A0A177BWT8"/>
    <dbReference type="OrthoDB" id="2538135at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050335">
        <property type="entry name" value="ERT1_acuK_gluconeogen_tf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056751">
        <property type="entry name" value="PAS_13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47659:SF1">
        <property type="entry name" value="TRANSCRIPTION ACTIVATOR OF GLUCONEOGENESIS ERT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47659">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24990">
        <property type="entry name" value="PAS_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="11">
        <location>
            <begin position="69"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="379"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="533"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="9"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="30"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="379"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="533"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="548"/>
            <end position="563"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OAF99862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="692" mass="75135" checksum="83C2EDF572A2636F" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BWT9</accession>
    <name>A0A177BWT9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1223093</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441562">
        <property type="protein sequence ID" value="OAF99420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029786.1">
        <property type="nucleotide sequence ID" value="XM_018183461.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BWT9"/>
    <dbReference type="STRING" id="1460663.A0A177BWT9"/>
    <dbReference type="GeneID" id="28766947"/>
    <dbReference type="InParanoid" id="A0A177BWT9"/>
    <dbReference type="OrthoDB" id="20872at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAF99420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="230" mass="25775" checksum="9117EE4B394E9F34" modified="2016-09-07" version="1">MEKHNIPDLFKLVWKTLLSSPTKFPDKHKGPTVTKNDHLNRRLISACEKGCAEICRLLVDEYGADIHHVSHNYSTTSLGRAAGSSANPIEGRLLVTRYLLEEKHVNIHMADGEFENSATSLAMLLKSGTKGQDEMIKPLLTHGRPLEEIGEGVLKVVEEAGSEANVELYLVLYRAPRETVKLMTERRTDGYRQVGVAASKEEWKTWLGTMQIRKSDEMLAAEDPKGRPLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BX74</accession>
    <name>A0A177BX74_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CC84DRAFT_1169085</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Has a physiological role leading to 18S rRNA stability.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the small ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS21 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441561">
        <property type="protein sequence ID" value="OAF99550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029916.1">
        <property type="nucleotide sequence ID" value="XM_018179570.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BX74"/>
    <dbReference type="FunCoup" id="A0A177BX74">
        <property type="interactions" value="916"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177BX74"/>
    <dbReference type="GeneID" id="28763056"/>
    <dbReference type="InParanoid" id="A0A177BX74"/>
    <dbReference type="OrthoDB" id="278325at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022626">
        <property type="term" value="C:cytosolic ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1230.20:FF:000001">
        <property type="entry name" value="40S ribosomal protein S21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1230.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001931">
        <property type="entry name" value="Ribosomal_eS21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018279">
        <property type="entry name" value="Ribosomal_eS21_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038579">
        <property type="entry name" value="Ribosomal_eS21_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10442">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01249">
        <property type="entry name" value="Ribosomal_S21e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002148">
        <property type="entry name" value="Ribosomal_S21e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00996">
        <property type="entry name" value="RIBOSOMAL_S21E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR002148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAF99550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="87" mass="9500" checksum="77160834C1BD864B" modified="2016-09-07" version="1">MENERGELVDLYIPRKCSATNRLIRPDDHGSVQISIANVDANGRAIPGDNTSFALCGFVRAMGEADDSLNRLAQQSGLLEKVWSPVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BXK3</accession>
    <name>A0A177BXK3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1222856</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441561">
        <property type="protein sequence ID" value="OAF99855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030221.1">
        <property type="nucleotide sequence ID" value="XM_018183431.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BXK3"/>
    <dbReference type="GeneID" id="28766917"/>
    <dbReference type="InParanoid" id="A0A177BXK3"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="46"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAF99855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="125" mass="13174" checksum="F84B6F908826FED7" modified="2016-09-07" version="1">MAAQVPPKCSDATNDKCDPVTAVGGDAGRKASTHDSSGVSGGGTTTGSAVNSSRSASYSYLFTSGGQRYNQPVAKKRTRYSPEYIPRKNVKKAEGAEKDKAVEKDKAAEKDKAAEKDKAAEKDTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BXM4</accession>
    <name>A0A177BXM4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Golgi apparatus membrane protein TVP23</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CC84DRAFT_1158022</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 8">Golgi membrane protein involved in vesicular trafficking.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 8">Golgi apparatus membrane</location>
            <topology evidence="2 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the TVP23 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441563">
        <property type="protein sequence ID" value="OAF99079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029445.1">
        <property type="nucleotide sequence ID" value="XM_018177038.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BXM4"/>
    <dbReference type="FunCoup" id="A0A177BXM4">
        <property type="interactions" value="383"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177BXM4"/>
    <dbReference type="GeneID" id="28760524"/>
    <dbReference type="InParanoid" id="A0A177BXM4"/>
    <dbReference type="OrthoDB" id="2151161at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008564">
        <property type="entry name" value="TVP23-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13019">
        <property type="entry name" value="GOLGI APPARATUS MEMBRANE PROTEIN TVP23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13019:SF7">
        <property type="entry name" value="GOLGI APPARATUS MEMBRANE PROTEIN TVP23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05832">
        <property type="entry name" value="DUF846"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="22"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="138"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAF99079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="197" mass="22219" checksum="B1E8F74CDCB53EF5" modified="2016-09-07" version="1">METAQQTPAPGSLSWRLSSHPITLLTYLFFRISSLLTYLFGLRLFTSNFVLIFIITILLLATDFYYLKNIAGRRLVGLRWWNEVDTASGDSRWVFESADPESREQNATDKRFFWIALYAQPVLWVLLAVVALLSFEPIWLTLVAIALVLTLTNALAYSRCDKFSHATGFASNAMYGSGLARNLASGMVSNWFSRGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2023-06-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BY37</accession>
    <name>A0A177BY37_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_357746</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441560">
        <property type="protein sequence ID" value="OAG00046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030411.1">
        <property type="nucleotide sequence ID" value="XM_018185889.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BY37"/>
    <dbReference type="GeneID" id="28769375"/>
    <dbReference type="InParanoid" id="A0A177BY37"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG00046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="179" mass="20703" checksum="4338E93EEC128F6B" modified="2016-09-07" version="1">MLRIAMIFHSVDFGHRLPVAEMTQSSPSDFLTCTPQIHCIDSDLKRFSSIHEVSRVKWQMWPVCVPLYKPSHCAQVTHTPQSKILAIDSHGYERQCRPVRKYHGLKSDRQSQPCISHRRAPRADLRSLIWRLKFRGHVALDQKCQIATELSNLASPTLITQPSHWAPRLTMELELIKLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BY46</accession>
    <name>A0A177BY46_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CC84DRAFT_1181100</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441561">
        <property type="protein sequence ID" value="OAF99608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029974.1">
        <property type="nucleotide sequence ID" value="XM_018180530.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BY46"/>
    <dbReference type="STRING" id="1460663.A0A177BY46"/>
    <dbReference type="GeneID" id="28764016"/>
    <dbReference type="InParanoid" id="A0A177BY46"/>
    <dbReference type="OrthoDB" id="3989227at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF40">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="14"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="53"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="76"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAF99608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="726" mass="80638" checksum="F4024928D5511CFB" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BYH5</accession>
    <name>A0A177BYH5_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_1209720</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441560">
        <property type="protein sequence ID" value="OAG00011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030376.1">
        <property type="nucleotide sequence ID" value="XM_018182233.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BYH5"/>
    <dbReference type="STRING" id="1460663.A0A177BYH5"/>
    <dbReference type="GeneID" id="28765719"/>
    <dbReference type="InParanoid" id="A0A177BYH5"/>
    <dbReference type="OrthoDB" id="3799861at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24126:SF14">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24126">
        <property type="entry name" value="ANKYRIN REPEAT, PH AND SEC7 DOMAIN CONTAINING PROTEIN SECG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="F-box" evidence="3">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAG00011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="499" mass="55532" checksum="CA5EA1FE2AE565EE" modified="2016-09-07" version="1">MGFADLPAELLQTILNHAIVVRGMKRGLRLRLINKRFAAEVIDTIYAYRMLDERFCQPLATVRNPPMPPFTASYIEYRIHNKEDDSSLAPYPKLGLLRRIAQDLVAENVSLPYDDCVRFLCRLISEGGADRVSQVFPPALPRPAYGHVLYETEEYYVDNLFAAAVVTNTVTIVERYIEIYRDKSFKPLLGMDSREFNLQAARYASPETLEVLLSGGHSHRVVVPRRNDMLVAAASVGRPSAFRFIHEFRIDETPWDFKDRAKRYASLQVFSDALLTPSREVWDHVMELRARYNCPKDVPEDRKQRVLAECIGQGGDADLLNHLLDLWPDIAEKNGFGDRASASPSGLLLDACANGYEDLVRVLLSRGASMSSAVIIAAAYGQTKIVRLLLEHGAAPFGGLLRAAGGGYMDVAHILLDAGVHPGETDPRLLMYPGLVTYGLTDVPIANACAMEHVELAKLLKEKGAKVNGHAGSECLRVTRKNGLESMLDLLDEWHCRGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BZ76</accession>
    <name>A0A177BZ76_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">1-alkyl-2-acetylglycerophosphocholine esterase</fullName>
            <ecNumber evidence="1">3.1.1.47</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CC84DRAFT_1264113</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.1.47" evidence="1"/>
    <dbReference type="EMBL" id="KV441561">
        <property type="protein sequence ID" value="OAF99746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030112.1">
        <property type="nucleotide sequence ID" value="XM_018185284.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BZ76"/>
    <dbReference type="GeneID" id="28768770"/>
    <dbReference type="InParanoid" id="A0A177BZ76"/>
    <dbReference type="OrthoDB" id="2363873at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003847">
        <property type="term" value="F:1-alkyl-2-acetylglycerophosphocholine esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10272:SF14">
        <property type="entry name" value="PAF ACETYLHYDROLASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10272">
        <property type="entry name" value="PLATELET-ACTIVATING FACTOR ACETYLHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03403">
        <property type="entry name" value="PAF-AH_p_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAF99746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="408" mass="44384" checksum="41C63EF717A4C424" modified="2016-09-07" version="1">MLTTQLIDYAHNAPFAPSKDIPRVLGLSIFYPTATNTTVATSYWPPENAAEESEGDITAGVNITYQGLLSLTVPLAPPNTSIAAPPVNAWFSSWPVLFFSPAFGETRFLYTSLLRQISSIGYVVITFETAYDTSVFVLANGTVVPGNSTLDNVSAEQATLSATARTEDASFILDHAHDNITWLIPGCKDTCVNTTNVGMFGHSIGGAASATAMFTDSRIIGGLNYDGALLGPVVQKGLSHRPFLIFGTQNQSRHNTGPLTTLTNWTTVWPRIKEAPKWWLLLNHSRHYTFSDLPLIAQKLGVKPNQTSLVAAQLTDADAERNEKVLVTYTAAFFKSVFTGKVEELMKGKSNKWPEVIFDSFSLNEKSRKGVNETDVQPVDNGAREQKARARGMALGMGLLALVISTYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BZD7</accession>
    <name>A0A177BZD7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">AAA-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CC84DRAFT_1169299</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441561">
        <property type="protein sequence ID" value="OAF99806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030172.1">
        <property type="nucleotide sequence ID" value="XM_018179630.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BZD7"/>
    <dbReference type="STRING" id="1460663.A0A177BZD7"/>
    <dbReference type="GeneID" id="28763116"/>
    <dbReference type="InParanoid" id="A0A177BZD7"/>
    <dbReference type="OrthoDB" id="10251136at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000022">
        <property type="entry name" value="Fidgetin like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000093">
        <property type="entry name" value="Fidgetin-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050304">
        <property type="entry name" value="MT-severing_AAA_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015415">
        <property type="entry name" value="Spast_Vps4_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23074">
        <property type="entry name" value="AAA DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23074:SF17">
        <property type="entry name" value="FIDGETIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09336">
        <property type="entry name" value="Vps4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="5">
        <location>
            <begin position="542"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="87"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="168"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="185"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="212"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="237"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="257"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="285"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="321"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="368"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="384"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="405"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="461"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAF99806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="798" mass="86964" checksum="9B1513118138AC9E" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BZY7</accession>
    <name>A0A177BZY7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_361578</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441560">
        <property type="protein sequence ID" value="OAG00162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030527.1">
        <property type="nucleotide sequence ID" value="XM_018185907.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BZY7"/>
    <dbReference type="GeneID" id="28769393"/>
    <dbReference type="InParanoid" id="A0A177BZY7"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG00162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="113" mass="12385" checksum="952383C171E5806F" modified="2016-09-07" version="1">MMLTTIFRLHIAGGTPLVRAWRGAPSIYHTRFSSAILLPFPLPYATHHPPTHSGNPQPTSVSLQYTILLCICIVCIETHAAARPTRLSARNPIRKLRLCVPASVPNGTAHADR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C0L3</accession>
    <name>A0A177C0L3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SWIM-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_301069</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441559">
        <property type="protein sequence ID" value="OAG00382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030747.1">
        <property type="nucleotide sequence ID" value="XM_018185792.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C0L3"/>
    <dbReference type="STRING" id="1460663.A0A177C0L3"/>
    <dbReference type="GeneID" id="28769278"/>
    <dbReference type="InParanoid" id="A0A177C0L3"/>
    <dbReference type="OrthoDB" id="5387895at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007527">
        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50966">
        <property type="entry name" value="ZF_SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SWIM-type" evidence="3">
        <location>
            <begin position="102"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="33"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAG00382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="451" mass="51074" checksum="A46AC48D5204F197" modified="2016-09-07" version="1">MSAEELSKLSLRDTMVTTRAGAARLRTNPPQTPQESPTSSPISPTPSLIESTNGHIYDISTFDDELRRRAKIGLVKDDNNIRMRFCRETDDGAFFFNLDDDITIKVEEGRVPKCSCGNVQNEKACKHIFWFIGQLSSVLPTNQTIQLAGDGSSVKNTHPAEVLKMRSLQAFADHFHWVVEGEDLPDTDELIDEVANMMSCFEPNGLLPAEFKSEDTRELSEQSRMFRELRPIVIQHAIRYPAFFMQLQELCSPEFQVKVFFEKINKRIDEAFNALDEYIERGPTNHRTPSLDVVSCAARLEGLVEKIEEYREDSLVSNAGERRDDTEIERLAALAYVRMLEEVTSRNNDAYANSPWVTTEPPSDPMRNNLFVRLIGPASEENGFFVLDKLQDMAPHVVRHHGVDLGEIENRVRNTPLTPPAYLSVLRSLIQESRKRAASQSGGNSPKRTMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C170</accession>
    <name>A0A177C170_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1209512</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441559">
        <property type="protein sequence ID" value="OAG00582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030947.1">
        <property type="nucleotide sequence ID" value="XM_018182222.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C170"/>
    <dbReference type="GeneID" id="28765708"/>
    <dbReference type="InParanoid" id="A0A177C170"/>
    <dbReference type="OrthoDB" id="3783329at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="697"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="943"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1007"/>
            <end position="1092"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1045"/>
            <end position="1057"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1074"/>
            <end position="1086"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG00582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="1117" mass="122093" checksum="7EABC688000C49CD" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C1G1</accession>
    <name>A0A177C1G1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 11">Alkaline phosphatase</fullName>
            <ecNumber evidence="2 11">3.1.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CC84DRAFT_1153312</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a phosphate monoester + H2O = an alcohol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15017"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:67140"/>
            <dbReference type="EC" id="3.1.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="9">Binds 1 Mg(2+) ion.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9">Binds 2 Zn(2+) ions.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the alkaline phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.1" evidence="2 11"/>
    <dbReference type="EMBL" id="KV441557">
        <property type="protein sequence ID" value="OAG01483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031848.1">
        <property type="nucleotide sequence ID" value="XM_018176834.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C1G1"/>
    <dbReference type="STRING" id="1460663.A0A177C1G1"/>
    <dbReference type="GeneID" id="28760320"/>
    <dbReference type="InParanoid" id="A0A177C1G1"/>
    <dbReference type="OrthoDB" id="7392499at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004035">
        <property type="term" value="F:alkaline phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16012">
        <property type="entry name" value="ALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.140">
        <property type="entry name" value="Alkaline phosphatase, crown domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001952">
        <property type="entry name" value="Alkaline_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018299">
        <property type="entry name" value="Alkaline_phosphatase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042085">
        <property type="entry name" value="Ap_crown"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11596">
        <property type="entry name" value="ALKALINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11596:SF5">
        <property type="entry name" value="ALKALINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00245">
        <property type="entry name" value="Alk_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00113">
        <property type="entry name" value="ALKPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00098">
        <property type="entry name" value="alkPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00123">
        <property type="entry name" value="ALKALINE_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 9 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="6 9 11" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008057577" description="Alkaline phosphatase" evidence="12">
        <location>
            <begin position="22"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphoserine intermediate" evidence="8">
        <location>
            <position position="87"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="284"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="289"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="293"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="331"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="332"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="421"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR601952-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR601952-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OAG01483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="495" mass="53446" checksum="A80357DC09242B92" modified="2016-09-07" version="1">MQYSLTLLAAGLVAQTGLTWAAPQAKNFIYIVPDGYGQASQTMARDYVSLQKTGSNASAPIIQELAGDRLVLGTVRTHASDNLVTDSAASGTAFSCGHKTYNDAISVTPDGQPVGSILEAAKLDGFKTALVVTSTINHATPAVYSAHVANRDSYEAIAAQQIGYSHPFGPVVDILLGGGRCYFKPQSDPTSCRSDDLDLFSFAQKKGYHVMQDRAAFDAYLGDYTTNASLPYIGLFNDDQMMYEIDRSKAPEKEPSLLEMSKAALGTLDQATRASKKGYFIMIEASRIDHAGHANDAAAHVHDTVMYNEVLGFVQEWINAHPDTMLMSAADHECGGLTTNAFDPAPLVNVQHSFEYLKTVWEAYNGTDARGYFTSTVLPAAGLSDVTDAQIDKLLGASSPWAEMKKMIATKAGVNWSTGGHTATDVTLHGYAAGKKWREFKGDMAGNHDNTELPRYIEKVLKLDMDATTAKLRAVNGSWVAGPDAARKRRDVHSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C1M3</accession>
    <name>A0A177C1M3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CC84DRAFT_1231091</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="KV441559">
        <property type="protein sequence ID" value="OAG00732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031097.1">
        <property type="nucleotide sequence ID" value="XM_018183714.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C1M3"/>
    <dbReference type="STRING" id="1460663.A0A177C1M3"/>
    <dbReference type="GeneID" id="28767200"/>
    <dbReference type="InParanoid" id="A0A177C1M3"/>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06609">
        <property type="entry name" value="STKc_MST3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000488">
        <property type="entry name" value="Related to severin kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000499">
        <property type="entry name" value="Serine/threonine-protein kinase KIC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050629">
        <property type="entry name" value="STE20/SPS1-PAK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012:SF10">
        <property type="entry name" value="FI20177P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012">
        <property type="entry name" value="STERILE20-LIKE KINASE, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="17"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="287"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="336"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="504"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="523"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="556"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="631"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OAG00732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="745" mass="81810" checksum="37EF5F2526A72445" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2023-06-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C2F7</accession>
    <name>A0A177C2F7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_238584</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441557">
        <property type="protein sequence ID" value="OAG01833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032198.1">
        <property type="nucleotide sequence ID" value="XM_018185637.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C2F7"/>
    <dbReference type="GeneID" id="28769123"/>
    <dbReference type="InParanoid" id="A0A177C2F7"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG01833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="157" mass="16965" checksum="4E6294CC92BF9BA5" modified="2016-09-07" version="1">MIQSAYEYSETLAKGNIPIRLDGACRPRHQADHPRNRALLPSVLRDHLRADVWGPQRRGQGLAAVWGFHCEIVRQGDTRGVQGSAGSGAGDCAEGAGRDWRGEGGFVQAGYVLVPEGCCERVVDSFGLGVQNRDGCIRSAFWNLHSMGYVLTSAHCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C337</accession>
    <name>A0A177C337_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">tRNA(His) guanylyltransferase</fullName>
            <ecNumber evidence="4">2.7.7.79</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">tRNA-histidine guanylyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CC84DRAFT_279923</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Adds a GMP to the 5'-end of tRNA(His) after transcription and RNase P cleavage.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a 5'-end ribonucleotide-tRNA(His) + GTP + ATP + H2O = a 5'-end phospho-guanosine-ribonucleotide-tRNA(His) + AMP + 2 diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54564"/>
            <dbReference type="Rhea" id="RHEA-COMP:14193"/>
            <dbReference type="Rhea" id="RHEA-COMP:14917"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:138282"/>
            <dbReference type="ChEBI" id="CHEBI:141847"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.7.79"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the tRNA(His) guanylyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.79" evidence="4"/>
    <dbReference type="EMBL" id="KV441558">
        <property type="protein sequence ID" value="OAG01198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031563.1">
        <property type="nucleotide sequence ID" value="XM_018185742.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C337"/>
    <dbReference type="STRING" id="1460663.A0A177C337"/>
    <dbReference type="GeneID" id="28769228"/>
    <dbReference type="InParanoid" id="A0A177C337"/>
    <dbReference type="OrthoDB" id="62560at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008193">
        <property type="term" value="F:tRNA guanylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.3000:FF:000001">
        <property type="entry name" value="tRNA(His) guanylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3000">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025845">
        <property type="entry name" value="Thg1_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024956">
        <property type="entry name" value="tRNAHis_GuaTrfase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007537">
        <property type="entry name" value="tRNAHis_GuaTrfase_Thg1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038469">
        <property type="entry name" value="tRNAHis_GuaTrfase_Thg1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12729">
        <property type="entry name" value="TRNA(HIS) GUANYLYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12729:SF6">
        <property type="entry name" value="TRNA(HIS) GUANYLYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04446">
        <property type="entry name" value="Thg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14413">
        <property type="entry name" value="Thg1C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNAHis guanylyltransferase catalytic" evidence="16">
        <location>
            <begin position="6"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="Thg1 C-terminal" evidence="17">
        <location>
            <begin position="140"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="220"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="258"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="325"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="259"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="15">
        <location>
            <begin position="286"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="359"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="377"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="399"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="570"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="610"/>
            <end position="666"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00032480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF04446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF14413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="OAG01198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="701" mass="76238" checksum="2E822C5257B5A096" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C4J5</accession>
    <name>A0A177C4J5_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Anucleate primary sterigmata protein B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CC84DRAFT_1124502</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG02664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033029.1">
        <property type="nucleotide sequence ID" value="XM_018175693.1"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177C4J5"/>
    <dbReference type="GeneID" id="28759179"/>
    <dbReference type="InParanoid" id="A0A177C4J5"/>
    <dbReference type="OrthoDB" id="10255000at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005815">
        <property type="term" value="C:microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012943">
        <property type="entry name" value="Cnn_1N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024545">
        <property type="entry name" value="Mto1-like_Mto2p-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23159">
        <property type="entry name" value="CENTROSOMAL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23159:SF31">
        <property type="entry name" value="CENTROSOME-ASSOCIATED PROTEIN CEP250 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07989">
        <property type="entry name" value="Cnn_1N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12808">
        <property type="entry name" value="Mto2_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Centrosomin N-terminal motif 1" evidence="5">
        <location>
            <begin position="496"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="domain" description="Mto1-like Mto2p-binding" evidence="6">
        <location>
            <begin position="1465"/>
            <end position="1516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="38"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="110"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="424"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="472"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="566"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="813"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1196"/>
            <end position="1226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1408"/>
            <end position="1428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1440"/>
            <end position="1460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1502"/>
            <end position="1541"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="663"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="1378"/>
            <end position="1405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="9"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="38"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="194"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="210"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="227"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="255"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="302"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="324"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="364"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="387"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="480"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="566"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1196"/>
            <end position="1210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1211"/>
            <end position="1226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1411"/>
            <end position="1428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1502"/>
            <end position="1516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1519"/>
            <end position="1533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAG02664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1541" mass="174834" checksum="7CCA9E51FE7A64EB" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C4P9</accession>
    <name>A0A177C4P9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1022849</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441556">
        <property type="protein sequence ID" value="OAG02475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032840.1">
        <property type="nucleotide sequence ID" value="XM_018173391.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C4P9"/>
    <dbReference type="GeneID" id="28756877"/>
    <dbReference type="InParanoid" id="A0A177C4P9"/>
    <dbReference type="OrthoDB" id="3789955at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG02475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="208" mass="23445" checksum="C60D2AD489771C91" modified="2016-09-07" version="1">MALTVPPQVHVNSKPFDTLLSVPGPLPSLCYANRKTRSECTPLLFLDTEIIVLNVLAVQRLAHYLRTPIRALVILTIYTLVFSPAISWRAHLAHATRVLLAACPTLRHVKIGVPHTVCVRENWGMVEEAEFGFTDVCVLRMRMRKEVVDQMDLCCLIDCKTLETVTLVCHEGERVARSLGSRREVVFMPLIVWVRKNICGGWEAEVDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C4W0</accession>
    <name>A0A177C4W0_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="5">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CC84DRAFT_1150420</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the HRD1 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="5"/>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG02535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032900.1">
        <property type="nucleotide sequence ID" value="XM_018176706.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C4W0"/>
    <dbReference type="STRING" id="1460663.A0A177C4W0"/>
    <dbReference type="GeneID" id="28760192"/>
    <dbReference type="InParanoid" id="A0A177C4W0"/>
    <dbReference type="OrthoDB" id="7759664at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16479">
        <property type="entry name" value="RING-H2_synoviolin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050731">
        <property type="entry name" value="HRD1_E3_ubiq-ligases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057992">
        <property type="entry name" value="TPR_SYVN1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058051">
        <property type="entry name" value="Znf_RING_synoviolin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22763:SF184">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SYNOVIOLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22763">
        <property type="entry name" value="RING ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25563">
        <property type="entry name" value="TPR_SYVN1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="14 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="12" id="KW-0862">Zinc</keyword>
    <keyword evidence="9 15" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="36"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="143"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="177"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="275"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="18">
        <location>
            <begin position="340"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="231"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="436"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="649"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="240"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="444"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="649"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="678"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="707"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="726"/>
            <end position="737"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="OAG02535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="769" mass="84641" checksum="DA1A9BB1BF274C41" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C5A4</accession>
    <name>A0A177C5A4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">18S rRNA aminocarboxypropyltransferase</fullName>
            <ecNumber evidence="6">2.5.1.157</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">TSR3</name>
        <name evidence="10" type="ORF">CC84DRAFT_1166524</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Aminocarboxypropyltransferase that catalyzes the aminocarboxypropyl transfer on pseudouridine at position 1191 (Psi1191) in 18S rRNA. It constitutes the last step in biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3-carboxypropyl) pseudouridine (m1acp3-Psi) conserved in eukaryotic 18S rRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>N(1)-methylpseudouridine(1191) in yeast 18S rRNA + S-adenosyl-L-methionine = N(1)-methyl-N(3)-[(3S)-3-amino-3-carboxypropyl]pseudouridine(1191) in yeast 18S rRNA + S-methyl-5'-thioadenosine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:63300"/>
            <dbReference type="Rhea" id="RHEA-COMP:13852"/>
            <dbReference type="Rhea" id="RHEA-COMP:16309"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74890"/>
            <dbReference type="ChEBI" id="CHEBI:146234"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>an N(1)-methylpseudouridine in rRNA + S-adenosyl-L-methionine = N(1)-methyl-N(3)-[(3S)-3-amino-3-carboxypropyl]pseudouridine in rRNA + S-methyl-5'-thioadenosine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:63296"/>
            <dbReference type="Rhea" id="RHEA-COMP:11634"/>
            <dbReference type="Rhea" id="RHEA-COMP:16310"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74890"/>
            <dbReference type="ChEBI" id="CHEBI:146234"/>
            <dbReference type="EC" id="2.5.1.157"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the TDD superfamily. TSR3 family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.157" evidence="6"/>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG02695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033060.1">
        <property type="nucleotide sequence ID" value="XM_018178981.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C5A4"/>
    <dbReference type="FunCoup" id="A0A177C5A4">
        <property type="interactions" value="801"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177C5A4"/>
    <dbReference type="GeneID" id="28762467"/>
    <dbReference type="InParanoid" id="A0A177C5A4"/>
    <dbReference type="OrthoDB" id="10262062at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106388">
        <property type="term" value="F:rRNA small subunit aminocarboxypropyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904047">
        <property type="term" value="F:S-adenosyl-L-methionine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000455">
        <property type="term" value="P:enzyme-directed rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01116">
        <property type="entry name" value="TSR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007209">
        <property type="entry name" value="RNaseL-inhib-like_metal-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022968">
        <property type="entry name" value="Tsr3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007177">
        <property type="entry name" value="Tsr3_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20426:SF0">
        <property type="entry name" value="18S RRNA AMINOCARBOXYPROPYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20426">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN TSR3 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04068">
        <property type="entry name" value="Fer4_RLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04034">
        <property type="entry name" value="Ribo_biogen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3 6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="5 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RNase L inhibitor RLI-like possible metal-binding" evidence="9">
        <location>
            <begin position="45"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="16S/18S rRNA aminocarboxypropyltransferase Tsr3 C-terminal" evidence="8">
        <location>
            <begin position="80"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="214"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="34"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="241"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="296"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="324"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAG02695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="387" mass="43142" checksum="463BEEC9D4765852" modified="2016-09-07" version="1">MVRHKKDFKKPRNRAPPPRRTSGSDNENEDGDTSAPRPSRAPKPACWDLGHCDAKRCSGKRLMRLGLLRELHVGQKFAGVVISPKAKKIVSREDAPLLEQYGAAVVEASWNRIEEVPFSRIGGPCSRLLPYLVAANQTNYGKPWRLNCVEAIAACYYICGHADWAEDILSSFSYGEAFLDINAALLKRYAACANEDEIKAAEEKWLAKLEKEYNDDRKEKEDGEADDIWAGGNVNRRQIDFSDDEDEDEEDEDAEDRQVTAAQNPYNLPESDDDEEEMAELRRRVLASKPFANPSSKDDVEDEKKQPERIARTEPGPDSASKEADDDDDSGSAPEAGDDDDDFDSFMAAQPTTDRTGIAGKQRQKALDKVTATFTSANLNAPNRRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2023-06-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C6K0</accession>
    <name>A0A177C6K0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1167422</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441556">
        <property type="protein sequence ID" value="OAG02367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032732.1">
        <property type="nucleotide sequence ID" value="XM_018179177.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C6K0"/>
    <dbReference type="GeneID" id="28762663"/>
    <dbReference type="InParanoid" id="A0A177C6K0"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG02367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="61" mass="6891" checksum="90A6ECF420DE913C" modified="2016-09-07" version="1">MRRPELLREGVSTSMMMKRYCRLPLSPRGGMDVPRQASGGLRPRRTAAPELIRLTQACYTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C6P6</accession>
    <name>A0A177C6P6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CC84DRAFT_1150446</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG02549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032914.1">
        <property type="nucleotide sequence ID" value="XM_018176707.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C6P6"/>
    <dbReference type="FunCoup" id="A0A177C6P6">
        <property type="interactions" value="71"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177C6P6"/>
    <dbReference type="GeneID" id="28760193"/>
    <dbReference type="InParanoid" id="A0A177C6P6"/>
    <dbReference type="OrthoDB" id="201656at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08267">
        <property type="entry name" value="MDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000147">
        <property type="entry name" value="Reticulon-4-interacting protein 1 homolog, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050700">
        <property type="entry name" value="YIM1/Zinc_Alcohol_DH_Fams"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11695">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11695:SF647">
        <property type="entry name" value="ENOYL REDUCTASE (ER) DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13602">
        <property type="entry name" value="ADH_zinc_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="6">
        <location>
            <begin position="16"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAG02549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="357" mass="39023" checksum="D932D64581081395" modified="2016-09-07" version="1">MSLPPSNTSLAYSLPSATPHLTHTPLKPPTPNQLIVKVLVAAVNPCDIQLWHSPLVGLGRLGREGTMGWDYSGIIAAVGDKMKGNWEAGDEVFGMCEGPAARGTFTKYLTVSDKAPIARKPKGWTFEEAASVPLVTLTAFACLDRLPPLKPTAAQRRIVVAGASGGTGMWCIQLAKKVYNCHVVAICSGRNAEFVRGLGADDVIDYTTSSVPELLLDYVSEGHKFDLYIDCVGGTDMFGTWKRIIQKQGAYITIVGDKTSRTVPGPPLTYFTYPAQILRHMWSWFSGPRYAAVILYNKSKYLEQVADLADKGEVKAVVQEVIEGILEEGKEKKAWERANVLLEEGRIRGKVVLKIQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C6Z9</accession>
    <name>A0A177C6Z9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_1150616</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG02642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033007.1">
        <property type="nucleotide sequence ID" value="XM_018176713.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C6Z9"/>
    <dbReference type="STRING" id="1460663.A0A177C6Z9"/>
    <dbReference type="GeneID" id="28760199"/>
    <dbReference type="InParanoid" id="A0A177C6Z9"/>
    <dbReference type="OrthoDB" id="2735536at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050425">
        <property type="entry name" value="NAD(P)_dehydrat-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366">
        <property type="entry name" value="NAD DEPENDENT EPIMERASE/DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366:SF564">
        <property type="entry name" value="STEROL-4-ALPHA-CARBOXYLATE 3-DEHYDROGENASE, DECARBOXYLATING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="3">
        <location>
            <begin position="6"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAG02642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="350" mass="36741" checksum="1D932585A2B9763A" modified="2016-09-07" version="1" fragment="single">MSKGTVLISGLNGFIAGVTAKYLLDNGYNVRGTVRKSSSATAIVEGPLKSYAESGALTVVEVPDITIPGAFDEAVKGITAIAHLASPVSFNFTDPDPIIKAALSGTTTILNSALKAGPQLKSFIFLSSIVAIMSGNPAPYTYTEKDWNNWAEPTVAAKGKDAPGAAIYCASKAAAEKAFWKFREDNKPAFAQTALNPVFVIGPPLIAPKTPADIGETIHAIWNIFSGGKFPPEGLTPGLGTTVDVRDVAAQIEYAIAHPDETDGERYLSSAAVATAQSTADILRKAFPEAKGRIVEGTPGKGYKSDYTLLDVENVQASDGSKAKKLLKGGAYIPHEKSVVDTARSFAHLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C706</accession>
    <name>A0A177C706_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Histone H1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CC84DRAFT_1166398</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the histone H1/H5 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG02558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032923.1">
        <property type="nucleotide sequence ID" value="XM_018178955.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C706"/>
    <dbReference type="STRING" id="1460663.A0A177C706"/>
    <dbReference type="GeneID" id="28762441"/>
    <dbReference type="InParanoid" id="A0A177C706"/>
    <dbReference type="OrthoDB" id="1110759at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00073">
        <property type="entry name" value="H15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005819">
        <property type="entry name" value="H1/H5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005818">
        <property type="entry name" value="Histone_H1/H5_H15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00538">
        <property type="entry name" value="Linker_histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00624">
        <property type="entry name" value="HISTONEH5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00526">
        <property type="entry name" value="H15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51504">
        <property type="entry name" value="H15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="2 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="H15" evidence="5">
        <location>
            <begin position="20"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="76"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="95"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="130"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="144"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="163"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="213"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="238"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00020833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAG02558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="250" mass="26065" checksum="2B2F4931A7413A90" modified="2016-09-07" version="1">MPPKKSTTASTKKAAAAAPAHGSYIDMVKDAIINLKERNGSSRQAIQKYIKANNSLGNPTDAMFKSRVNGAIRKGLESGDFSFPKGQKSGSIKLAKKDAKEAKPAAAKKEKAEPKVEKKTAAPKAKKATATKAKATTTKKAPAAKKETKATKAATPKKETKTKAAAAKPKANASKPRKAAEAPAVPKEDFAVLSKTKSGRVTKTKAAAPTKKAPAKKAAKAAPKKTTPAKKAAETKKTTPKRATPKKTAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C723</accession>
    <name>A0A177C723_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FHA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1261379</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG02662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033027.1">
        <property type="nucleotide sequence ID" value="XM_018185059.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C723"/>
    <dbReference type="STRING" id="1460663.A0A177C723"/>
    <dbReference type="GeneID" id="28768545"/>
    <dbReference type="InParanoid" id="A0A177C723"/>
    <dbReference type="OrthoDB" id="444265at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22676">
        <property type="entry name" value="FHA_SNIP1_DDL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050923">
        <property type="entry name" value="Cell_Proc_Reg/RNA_Proc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23308">
        <property type="entry name" value="NUCLEAR INHIBITOR OF PROTEIN PHOSPHATASE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="2">
        <location>
            <begin position="386"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="256"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG02662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="488" mass="56131" checksum="AF270894A1E78B0A" modified="2016-09-07" version="1">MPERELSPYSARVALTRQLQQGQGSQSAPPAQLNRRPWDTRGPPPERRHNGSNHSPMPQRGRGRGGRPSPPLVRGREGREESASPPPRSRRDSPPPERSPKAKSKDASVEPARSVRDCEASPEPYRKPREASTERKRDRSKDRHSRRDRDPVKDQDRPRERERTKGRDRSRESYRLKGRDRSRESHRSKGKDRSRERDMSKGRDRSRDRHREKRRERSTERRRDGSRERKRSRDRGSRRARSHSRDKDRHRRRSRSPLPVTRRSPSSSPPPKRRRKHTSSPSRSPSPHPRSKRPLPDQEISFRGTDTSALPPTKYGGAPANLEKPNFKPTGLLAKAANKVEGTKISLKYHEPPEARKPPPSQAWRIVVFKGDDVVDSIELGSKSCWLLGREAKVVDYVLEHPSSSGQHAVVQFRYVTKTVEDEYGVKKTRGKVKPYLIDLESSNGTVLNGERVETSRYLELRDKDILKFAGSEREYVVVLPPPEEAKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C7M8</accession>
    <name>A0A177C7M8_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">eIF-2-alpha kinase activator GCN1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CC84DRAFT_1260849</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GCN1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG03754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034119.1">
        <property type="nucleotide sequence ID" value="XM_018185016.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A177C7M8">
        <property type="interactions" value="1380"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177C7M8"/>
    <dbReference type="GeneID" id="28768502"/>
    <dbReference type="InParanoid" id="A0A177C7M8"/>
    <dbReference type="OrthoDB" id="5148094at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022626">
        <property type="term" value="C:cytosolic ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043008">
        <property type="term" value="F:ATP-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043539">
        <property type="term" value="F:protein serine/threonine kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0170011">
        <property type="term" value="F:stalled ribosome sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034198">
        <property type="term" value="P:cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140469">
        <property type="term" value="P:GCN2-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031571">
        <property type="term" value="P:mitotic G1 DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904689">
        <property type="term" value="P:negative regulation of cytoplasmic translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071264">
        <property type="term" value="P:positive regulation of translational initiation in response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990611">
        <property type="term" value="P:regulation of cytoplasmic translational initiation in response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006448">
        <property type="term" value="P:regulation of translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072344">
        <property type="term" value="P:rescue of stalled ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000090">
        <property type="entry name" value="eIF-2-alpha kinase activator GCN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022716">
        <property type="entry name" value="Gcn1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056810">
        <property type="entry name" value="GNC1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057546">
        <property type="entry name" value="HEAT_GCN1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056809">
        <property type="entry name" value="HEAT_GCN1_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034085">
        <property type="entry name" value="TOG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23346:SF7">
        <property type="entry name" value="STALLED RIBOSOME SENSOR GCN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23346">
        <property type="entry name" value="TRANSLATIONAL ACTIVATOR GCN1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12074">
        <property type="entry name" value="Gcn1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24993">
        <property type="entry name" value="GNC1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24984">
        <property type="entry name" value="HEAT_EF3_GNC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24987">
        <property type="entry name" value="HEAT_EF3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23271">
        <property type="entry name" value="HEAT_GCN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25801">
        <property type="entry name" value="HEAT_GCN1_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24916">
        <property type="entry name" value="HEAT_GCN1_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01349">
        <property type="entry name" value="TOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="TOG" evidence="6">
        <location>
            <begin position="1351"/>
            <end position="1587"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="4">
        <location>
            <begin position="1528"/>
            <end position="1565"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="4">
        <location>
            <begin position="1988"/>
            <end position="2025"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="2641"/>
            <end position="2661"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00072275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAG03754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="2680" mass="292994" checksum="2075CA551AE589E7" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C7N2</accession>
    <name>A0A177C7N2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1166664</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG02859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033224.1">
        <property type="nucleotide sequence ID" value="XM_018179019.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C7N2"/>
    <dbReference type="GeneID" id="28762505"/>
    <dbReference type="InParanoid" id="A0A177C7N2"/>
    <dbReference type="OrthoDB" id="10338094at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG02859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="150" mass="17536" checksum="CF38B425D629648C" modified="2016-09-07" version="1">MASIQYFPHQSIIALQHNRDIRYNPNMDGGSLRCYAPQYYHAQDTVTHMLTLPTPLVSIPTSQPARRTVTRFEEVCKVRREIVEEDVHVLEVTDDRVWSTGCARWWTQTELKWNGHVEHPESCERSSIVREAAYQHTLNLGNEKRSMKTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C7T2</accession>
    <name>A0A177C7T2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1207720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG02909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033274.1">
        <property type="nucleotide sequence ID" value="XM_018182116.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C7T2"/>
    <dbReference type="STRING" id="1460663.A0A177C7T2"/>
    <dbReference type="GeneID" id="28765602"/>
    <dbReference type="InParanoid" id="A0A177C7T2"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF226">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="1">
        <location>
            <position position="432"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG02909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="498" mass="55623" checksum="26004428AFCBBF49" modified="2016-09-07" version="1">MGRGACSPIILPSIDDGISSPRFRFLRDKFRAAPNTVLFNSPRAYTDIHGTRANIIRGNFYKAWKCDEHDLHTVNAMEPALHAKRRKLLNLAFTEQSLKATSPIIARHIDRWIFLLSSTVGSNRNVHDAKSGDTEAWSQPVDMAERVEYLVFDILGELCFGESFNTKEPGANMLKEVTGQILNQVAFGYKLSKSPFYNLFLFFQPRGLNRLLARLRKREVVAYNEFVENSVTKRIAAHKADPSGSQKDMFHFLLTVIDPDTDRPAFSDRGHILSETRLLALTGTDTTATTLCGAFFYLAQYPNVLAKLPCEIRTTFQSSEKIELGAKLSNCKYLRACIDESLRIAHPAPSELPQEVLPGGAVIDGEHYPAGTLVGCAAWAMGRDENVYGDDVDVFRPERWIPSDDANASKTDAEVLKLRRTFHPFSVGPMNCAGQNLAVLELQMVLAKTVWALDFNLSSSDDTDGDALDQPCPPVYHVKDIYLSMKTGPFLRFKPRLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C8A3</accession>
    <name>A0A177C8A3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DNA polymerase eta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CC84DRAFT_1151227</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG02987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033352.1">
        <property type="nucleotide sequence ID" value="XM_018176735.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C8A3"/>
    <dbReference type="FunCoup" id="A0A177C8A3">
        <property type="interactions" value="599"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177C8A3"/>
    <dbReference type="GeneID" id="28760221"/>
    <dbReference type="InParanoid" id="A0A177C8A3"/>
    <dbReference type="OrthoDB" id="5723at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005657">
        <property type="term" value="C:replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070987">
        <property type="term" value="P:error-free translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042276">
        <property type="term" value="P:error-prone translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007064">
        <property type="term" value="P:mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009314">
        <property type="term" value="P:response to radiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.100:FF:000009">
        <property type="entry name" value="DNA polymerase eta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1170.60:FF:000008">
        <property type="entry name" value="DNA polymerase eta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000014">
        <property type="entry name" value="Polymerase (DNA directed), eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.100">
        <property type="entry name" value="DNA polymerase, Y-family, little finger domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036775">
        <property type="entry name" value="DNA_pol_Y-fam_lit_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017961">
        <property type="entry name" value="DNA_pol_Y-fam_little_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052230">
        <property type="entry name" value="DNA_polymerase_eta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041298">
        <property type="entry name" value="UBZ3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001126">
        <property type="entry name" value="UmuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45873">
        <property type="entry name" value="DNA POLYMERASE ETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45873:SF1">
        <property type="entry name" value="DNA POLYMERASE ETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00817">
        <property type="entry name" value="IMS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11799">
        <property type="entry name" value="IMS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21704">
        <property type="entry name" value="POLH-Rev1_HhH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18439">
        <property type="entry name" value="zf_UBZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036603">
        <property type="entry name" value="DPol_eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100879">
        <property type="entry name" value="Lesion bypass DNA polymerase (Y-family), little finger domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50173">
        <property type="entry name" value="UMUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51907">
        <property type="entry name" value="ZF_UBZ3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UmuC" evidence="11">
        <location>
            <begin position="47"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="UBZ3-type" evidence="12">
        <location>
            <begin position="622"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="497"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="669"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="497"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="550"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="586"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="597"/>
            <end position="621"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OAG02987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="705" mass="78785" checksum="A04858D2DF36E11B" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C8A7</accession>
    <name>A0A177C8A7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glutathione S-transferas-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CC84DRAFT_1166781</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG03008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033373.1">
        <property type="nucleotide sequence ID" value="XM_018179048.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C8A7"/>
    <dbReference type="STRING" id="1460663.A0A177C8A7"/>
    <dbReference type="GeneID" id="28762534"/>
    <dbReference type="InParanoid" id="A0A177C8A7"/>
    <dbReference type="OrthoDB" id="2309723at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03190">
        <property type="entry name" value="GST_C_Omega_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000475">
        <property type="entry name" value="Cell wall organization protein/glutathione transferase (Gto3), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047047">
        <property type="entry name" value="GST_Omega-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016639">
        <property type="entry name" value="GST_Omega/GSH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32419:SF23">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32419">
        <property type="entry name" value="GLUTATHIONYL-HYDROQUINONE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13410">
        <property type="entry name" value="GST_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13409">
        <property type="entry name" value="GST_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015753">
        <property type="entry name" value="GST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01206">
        <property type="entry name" value="Xi.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01148">
        <property type="entry name" value="Xi_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="4">
        <location>
            <begin position="39"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="40"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="1">
        <location>
            <position position="181"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>glutathione</name>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="111"/>
            <end position="114"/>
        </location>
        <ligand>
            <name>glutathione</name>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="129"/>
            <end position="130"/>
        </location>
        <ligand>
            <name>glutathione</name>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Cys" evidence="3">
        <location>
            <position position="241"/>
        </location>
    </feature>
    <feature type="site" description="Lowers pKa of active site Cys" evidence="3">
        <location>
            <position position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR015753-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR015753-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR015753-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAG03008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="334" mass="38253" checksum="95E1A807C81D22A9" modified="2016-09-07" version="1">MGASDIHKYGTDDGWHGKIEEGGEFPPEKDRYHLYIGLFCPFAHRVNLVRHIKHLTPYITLDVVRPYPKDGGGWRFPASNDEYPGATVDSLFGSKFLSEVYFRDDKDYKGKYSVPLLWDKKAGKIVNNDSAEMLRWLPNAFDIFFSDDDAIKKINLYPEPLRAKIDEIGPWMQSYINAGVYKAGFALTQEAYEAGVLPLFAALNKIEALLASIGGPYVLGMQLTELDLRLYATVIRFDTVYVQHFKTNLGTIRHDYPTLNNWHKNLYWNVEGFRESTDFKHIKENYTKSHGDVNPLAITPLGPFPEVEEGYDEDWRKVRVGEVRHPAVLKEEAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C8H2</accession>
    <name>A0A177C8H2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CC84DRAFT_1219107</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG03845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034210.1">
        <property type="nucleotide sequence ID" value="XM_018183055.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C8H2"/>
    <dbReference type="STRING" id="1460663.A0A177C8H2"/>
    <dbReference type="GeneID" id="28766541"/>
    <dbReference type="InParanoid" id="A0A177C8H2"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11058">
        <property type="entry name" value="CYP60B-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF210">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE ASQL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 7" id="KW-0349">Heme</keyword>
    <keyword evidence="5 6 7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="6">
        <location>
            <position position="457"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAG03845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="511" mass="57988" checksum="95A102C4F369AD57" modified="2016-09-07" version="1">MSSTLDDTSTLLFKLFRNASGGVLITLTLATLIGYFVFRTIYRLYLHPLSKFPGPKFHAVSHIPAVLATWNGEQHRRVARLHQQYGTVVRISPEEVSFIDPDAWKDIYGHGSKGVSGPHKPWSRHGKYINGATSLIIAPDADHTRMRRLFNPAFSDRALKQQEPLFLKYINLLAEKLREGIEEDPDRKFDMVKMYNFTTFDIMGDLTFGEPLQMLSKAKYDPWVTAIFRGIKAGTRLSVLADYPLVEKTFKSLIPQSVMVKKQYEHHSFAEERVAKRLEKGREHEGVDIWDLVLSKSAEKGLSRAEMDNNAGLFMLAGTETTATLVSGLTALLLDHPRTMRELSTEIRKAFSGPEEMTIEKCATLPYLNACIKEALRLYPPVAMGRPRVSAPQGSTICGHYIPPGYMVSAPHLAMSTSASNFKDPLSFVPERWLGDPRFESDKRHAVQPFHVGPRDCIGKNMAYHEMRLIMTRVLYTFDLELCEESRNWGDQNCYIIWEKKPLMCTLKAVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C8H6</accession>
    <name>A0A177C8H6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NGG1p interacting factor 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_1096221</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GTP cyclohydrolase I type 2/NIF3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG03431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033796.1">
        <property type="nucleotide sequence ID" value="XM_018174660.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C8H6"/>
    <dbReference type="FunCoup" id="A0A177C8H6">
        <property type="interactions" value="644"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177C8H6"/>
    <dbReference type="GeneID" id="28758146"/>
    <dbReference type="InParanoid" id="A0A177C8H6"/>
    <dbReference type="OrthoDB" id="3345469at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1390.30:FF:000001">
        <property type="entry name" value="GTP cyclohydrolase 1 type 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1390.30">
        <property type="entry name" value="NIF3 (NGG1p interacting factor 3)-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002678">
        <property type="entry name" value="DUF34/NIF3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036069">
        <property type="entry name" value="DUF34/NIF3_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00486">
        <property type="entry name" value="YbgI_SA1388"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13799">
        <property type="entry name" value="NGG1 INTERACTING FACTOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13799:SF13">
        <property type="entry name" value="NIF3-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01784">
        <property type="entry name" value="DUF34_NIF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102705">
        <property type="entry name" value="NIF3 (NGG1p interacting factor 3)-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="123"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="140"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="297"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="301"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR602678-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAG03431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="365" mass="39603" checksum="33026D1C833A00A3" modified="2016-09-07" version="1">MSLQLTFTSYPEALADNSWDNTGLLLEAPFVPTRRQSNNVLLTIDLTKAVADEAIELNSSIIIAYHPIIFRGLKSITLANSQQQTLLRLASHGISVYSPHTAVDAAPGGLGDWLADIVTGNKKTPGLEKSEAGSDAGNTQKKEDEDPFVEDKRPKRPTWALAHHPSSMQTTFRLGSQSTPLSTIPHTRKPIIPQSPELETHPGAGMGRVVTFDTPQPLPALLDRIGRGLNNPKGFPIAIPQTAQMSELTIRSVGICAGSGASLLSHLDVDLLFTGEMSHHEALAAIEKGQVVINLFHSNSERGFLSDVLLPQLDDAVEEEWKNLRDDETGAEGLEEALADENFEIMLSEVDRDPYGIVVLDNDGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CAG1</accession>
    <name>A0A177CAG1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_888760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG04121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034486.1">
        <property type="nucleotide sequence ID" value="XM_018187801.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CAG1"/>
    <dbReference type="GeneID" id="28771287"/>
    <dbReference type="InParanoid" id="A0A177CAG1"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG04121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="131" mass="15480" checksum="CBC2E35252541CB1" modified="2016-09-07" version="1">MSRLTTDRLFVAILTRPRSRRTWKGCAMDQYRRVIKSIRNATRPFSEPWGREANMTKGRYPADYFLQVFTYFVKGMPHEYHLTKPRKLEVYRCSCSRKTLSRMYYGGCGFFGRLAFVTVYQGLIPVYPIPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CBD4</accession>
    <name>A0A177CBD4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">UBC core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CC84DRAFT_1166276</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG04172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034537.1">
        <property type="nucleotide sequence ID" value="XM_018178918.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CBD4"/>
    <dbReference type="STRING" id="1460663.A0A177CBD4"/>
    <dbReference type="GeneID" id="28762404"/>
    <dbReference type="InParanoid" id="A0A177CBD4"/>
    <dbReference type="OrthoDB" id="109543at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00195">
        <property type="entry name" value="UBCc_UEV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="3">
        <location>
            <begin position="11"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="F-box" evidence="4">
        <location>
            <begin position="195"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="631"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="644"/>
            <end position="654"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAG04172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="654" mass="74460" checksum="5BC6B894E7A60E51" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CBQ9</accession>
    <name>A0A177CBQ9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="23">Phospholipid-transporting ATPase</fullName>
            <ecNumber evidence="23">7.6.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="27" type="ORF">CC84DRAFT_1092876</name>
    </gene>
    <organism evidence="27 28">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="27 28" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="27 28">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15 23">
            <text>ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.</text>
            <dbReference type="EC" id="7.6.2.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-L-serine(out) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phospho-L-serine(in) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38567"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:38568"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>a 1,2-diacyl-sn-glycero-3-phosphocholine(out) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phosphocholine(in) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38583"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:38584"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66132"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:66133"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>a beta-D-glucosyl-(1&lt;-&gt;1')-N-acylsphing-4-enine(out) + ATP + H2O = a beta-D-glucosyl-(1&lt;-&gt;1')-N-acylsphing-4-enine(in) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66036"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:22801"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:66037"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 22">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="23">Membrane</location>
            <topology evidence="23">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 23">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.1" evidence="23"/>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG05055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035420.1">
        <property type="nucleotide sequence ID" value="XM_018174488.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A177CBQ9">
        <property type="interactions" value="43"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CBQ9"/>
    <dbReference type="GeneID" id="28757974"/>
    <dbReference type="InParanoid" id="A0A177CBQ9"/>
    <dbReference type="OrthoDB" id="377733at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140351">
        <property type="term" value="F:glycosylceramide flippase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090554">
        <property type="term" value="F:phosphatidylcholine floppase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090556">
        <property type="term" value="F:phosphatidylserine floppase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045332">
        <property type="term" value="P:phospholipid translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02073">
        <property type="entry name" value="P-type_ATPase_APLT_Dnf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000035">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000108">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000001">
        <property type="entry name" value="Phospholipid-transporting ATPase IC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006539">
        <property type="entry name" value="P-type_ATPase_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032631">
        <property type="entry name" value="P-type_ATPase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032630">
        <property type="entry name" value="P_typ_ATPase_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01652">
        <property type="entry name" value="ATPase-Plipid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092:SF180">
        <property type="entry name" value="PHOSPHOLIPID-TRANSPORTING ATPASE DNF1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092">
        <property type="entry name" value="PROBABLE PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16212">
        <property type="entry name" value="PhoLip_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16209">
        <property type="entry name" value="PhoLip_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 21 23" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="10 22 23" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14 23" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 22" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 21 23" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 23" id="KW-1278">Translocase</keyword>
    <keyword evidence="6 23" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 23" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="131"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="494"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="541"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="1109"/>
            <end position="1129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="1141"/>
            <end position="1162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="1192"/>
            <end position="1214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="1234"/>
            <end position="1251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="1258"/>
            <end position="1274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="1294"/>
            <end position="1313"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase N-terminal" evidence="25">
        <location>
            <begin position="102"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase C-terminal" evidence="26">
        <location>
            <begin position="1078"/>
            <end position="1327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="230"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="1374"/>
            <end position="1434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="1465"/>
            <end position="1531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="24">
        <location>
            <begin position="29"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="24">
        <location>
            <begin position="244"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="24">
        <location>
            <begin position="1393"/>
            <end position="1415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="24">
        <location>
            <begin position="1425"/>
            <end position="1434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="24">
        <location>
            <begin position="1468"/>
            <end position="1481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="24">
        <location>
            <begin position="1495"/>
            <end position="1508"/>
        </location>
    </feature>
    <feature type="active site" description="4-aspartylphosphate intermediate" evidence="20">
        <location>
            <position position="608"/>
        </location>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="608"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="608"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="609"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="610"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="610"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="742"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="783"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="806"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="841"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="921"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="922"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="923"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="1026"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="1032"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="1052"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="1055"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="1056"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="1056"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00034036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00050913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00051303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00052223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="RuleBase" id="RU362033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="Pfam" id="PF16209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="Pfam" id="PF16212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="EMBL" id="OAG05055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="1531" mass="171802" checksum="0E8FF40F256BBAAD" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CBR7</accession>
    <name>A0A177CBR7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_799860</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG04631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034996.1">
        <property type="nucleotide sequence ID" value="XM_018187453.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CBR7"/>
    <dbReference type="GeneID" id="28770939"/>
    <dbReference type="InParanoid" id="A0A177CBR7"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="84"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG04631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="141" mass="15859" checksum="AA5AB26722B51D11" modified="2016-09-07" version="1">MSHELDSLTPLATGFPTTGSTQRFSSTTREERIHRSCSTSRYKSMWAAEKRSYTETLPPTPRRYTCFNWIPVAFSRMDKTRRKFLLLLLPVCVPLLLVHRHVTLITHGTLPFGSLGVSHSDSSSESVHKTVNSTLGVSYSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CC18</accession>
    <name>A0A177CC18_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="14">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CC84DRAFT_1165117</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Calcium-dependent, calmodulin-stimulated protein phosphatase. This subunit may have a role in the calmodulin activation of calcineurin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Fe(3+)</name>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Composed of two components (A and B), the A component is the catalytic subunit and the B component confers calcium sensitivity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PPP phosphatase family. PP-2B subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="14"/>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG04741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035106.1">
        <property type="nucleotide sequence ID" value="XM_018178644.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CC18"/>
    <dbReference type="FunCoup" id="A0A177CC18">
        <property type="interactions" value="501"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CC18"/>
    <dbReference type="GeneID" id="28762130"/>
    <dbReference type="InParanoid" id="A0A177CC18"/>
    <dbReference type="OrthoDB" id="5593063at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033192">
        <property type="term" value="F:calmodulin-dependent protein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097720">
        <property type="term" value="P:calcineurin-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07416">
        <property type="entry name" value="MPP_PP2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000002">
        <property type="entry name" value="Serine/threonine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041751">
        <property type="entry name" value="MPP_PP2B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043360">
        <property type="entry name" value="PP2B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45673">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="6 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="16">
        <location>
            <begin position="182"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="413"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="513"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="513"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="552"/>
            <end position="563"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00053858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="OAG04741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="563" mass="64318" checksum="3473021CAAA5F101" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CCZ4</accession>
    <name>A0A177CCZ4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1218107</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG04677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035042.1">
        <property type="nucleotide sequence ID" value="XM_018182966.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CCZ4"/>
    <dbReference type="GeneID" id="28766452"/>
    <dbReference type="InParanoid" id="A0A177CCZ4"/>
    <dbReference type="OrthoDB" id="10439824at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG04677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="162" mass="17529" checksum="A24D514E29AF3099" modified="2016-09-07" version="1">MPSTSDATAALATLSLIKPTPAIRDLRALLTDAERMQHSFDDRPALRASPARRELLHEVLKDLLGLRNQVFTRYKRDLTGKGKATSSEEGGVDGDGHADNTAYGNVFAEVGAVIEELRLWGKVEKLLGGVLEGCRVEGVFSSEQMRVLKGACEPGFDWGFGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CD87</accession>
    <name>A0A177CD87_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">CENP-V/GFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CC84DRAFT_1059910</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfa family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG04670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035035.1">
        <property type="nucleotide sequence ID" value="XM_018173574.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CD87"/>
    <dbReference type="STRING" id="1460663.A0A177CD87"/>
    <dbReference type="GeneID" id="28757060"/>
    <dbReference type="InParanoid" id="A0A177CD87"/>
    <dbReference type="OrthoDB" id="9970124at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016846">
        <property type="term" value="F:carbon-sulfur lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1590.10">
        <property type="entry name" value="glutathione-dependent formaldehyde- activating enzyme (gfa)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006913">
        <property type="entry name" value="CENP-V/GFA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337:SF40">
        <property type="entry name" value="CENP-V_GFA DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337">
        <property type="entry name" value="GFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04828">
        <property type="entry name" value="GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51891">
        <property type="entry name" value="CENP_V_GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CENP-V/GFA" evidence="6">
        <location>
            <begin position="32"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="166"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="178"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAG04670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="201" mass="23737" checksum="B31987F2E69EAE2B" modified="2016-09-07" version="1" fragment="single">QRRGEETTGISEWKMRPPYRVHEKNEHFDAKYEANCHCGKVQYQLSRKEPLDSKLCHCTTCQTQHAAPFQWAAIFHKTDINFSEGHHNLEWYDPTEKSIEHKLPCKVRCSYCHSPIMDEGRNMILLFPSLIHLKTDEDKALFKPRCHMFYGQRVMDIPDGLPKWSGLSDSSDLIEDSPPEKVKEMQRKMEEERKERFEKGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CE45</accession>
    <name>A0A177CE45_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Nucleoporin NSP1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Nuclear pore protein NSP1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Nucleoskeletal-like protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CC84DRAFT_1119431</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Nucleoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the nucleoporin NSP1/NUP62 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG05903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036268.1">
        <property type="nucleotide sequence ID" value="XM_018175551.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CE45"/>
    <dbReference type="STRING" id="1460663.A0A177CE45"/>
    <dbReference type="GeneID" id="28759037"/>
    <dbReference type="InParanoid" id="A0A177CE45"/>
    <dbReference type="OrthoDB" id="344345at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044613">
        <property type="term" value="C:nuclear pore central transport channel"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006405">
        <property type="term" value="P:RNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000040">
        <property type="entry name" value="Nuclear pore glycoprotein p62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026010">
        <property type="entry name" value="NSP1/NUP62"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007758">
        <property type="entry name" value="Nucleoporin_NSP1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12084:SF0">
        <property type="entry name" value="NUCLEAR PORE GLYCOPROTEIN P62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12084">
        <property type="entry name" value="NUCLEAR PORE GLYCOPROTEIN P62-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05064">
        <property type="entry name" value="Nsp1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="9" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nucleoporin NSP1-like C-terminal" evidence="16">
        <location>
            <begin position="482"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="678"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="601"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="34"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="55"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="79"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="15">
        <location>
            <begin position="95"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="114"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="140"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="170"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="238"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="260"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="310"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="327"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="349"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="377"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="409"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="476"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="699"/>
            <end position="716"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004620"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00068864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00078941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00081079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF05064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="OAG05903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="716" mass="70567" checksum="4BB085EE5A98673C" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CE50</accession>
    <name>A0A177CE50_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1206659</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG05192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035557.1">
        <property type="nucleotide sequence ID" value="XM_018182041.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CE50"/>
    <dbReference type="STRING" id="1460663.A0A177CE50"/>
    <dbReference type="GeneID" id="28765527"/>
    <dbReference type="InParanoid" id="A0A177CE50"/>
    <dbReference type="OrthoDB" id="5131368at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG05192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="181" mass="20263" checksum="3FD6B505266114D6" modified="2016-09-07" version="1">MCHSPSSPATRKLQAHHPSSLQTQDGQLEPRNPPTHGLDTLNFNNSFLSPEFAPTEMRTVVQGAILIGVGGTAVLLQMAMPGIGARVGYSDDDSGLELWAAATLHSATPVVLEICARLGPYFRWDAQRRREYGVWRLNSMQMSFVRLIAVEWMPILLREPFWVEEDSRGRRVGYWVVSVMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CEE3</accession>
    <name>A0A177CEE3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1206622</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG05137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035502.1">
        <property type="nucleotide sequence ID" value="XM_018182040.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CEE3"/>
    <dbReference type="GeneID" id="28765526"/>
    <dbReference type="InParanoid" id="A0A177CEE3"/>
    <dbReference type="OrthoDB" id="444540at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13202">
        <property type="entry name" value="EF-hand_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008058102" description="EF-hand domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="2">
        <location>
            <begin position="79"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="2">
        <location>
            <begin position="116"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG05137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="142" mass="15020" checksum="25D624E7FA3E3F01" modified="2016-09-07" version="1">MRFIAVAAVLGSMLPLTLAYCCGGDGSGICGDGTTQGAGCCGYGPCNIFCCNCDPSGGTCRGGRGNKRMSELPAAFKRDVDAGTEATFNEIDKSGSGSFSLQEYLEWMNVSADNSQVHEHWVSWFKQHDTNDDGVITLEEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CET3</accession>
    <name>A0A177CET3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Bromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CC84DRAFT_1148567</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG05267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035632.1">
        <property type="nucleotide sequence ID" value="XM_018176642.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CET3"/>
    <dbReference type="STRING" id="1460663.A0A177CET3"/>
    <dbReference type="GeneID" id="28760128"/>
    <dbReference type="InParanoid" id="A0A177CET3"/>
    <dbReference type="OrthoDB" id="21449at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd04369">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15398">
        <property type="entry name" value="BROMODOMAIN-CONTAINING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15398:SF4">
        <property type="entry name" value="BROMODOMAIN-CONTAINING PROTEIN 8 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bromo" evidence="5">
        <location>
            <begin position="666"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="75"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="156"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="788"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="124"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="163"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="227"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="246"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="313"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="329"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="355"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="388"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="422"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="445"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="471"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="495"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="519"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="541"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="573"/>
            <end position="591"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAG05267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="821" mass="89469" checksum="846A09DA8187954D" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CEV8</accession>
    <name>A0A177CEV8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HET-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1093499</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG05338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035703.1">
        <property type="nucleotide sequence ID" value="XM_018174515.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CEV8"/>
    <dbReference type="STRING" id="1460663.A0A177CEV8"/>
    <dbReference type="GeneID" id="28758001"/>
    <dbReference type="InParanoid" id="A0A177CEV8"/>
    <dbReference type="OrthoDB" id="5362512at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF10">
        <property type="entry name" value="TOL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="2">
        <location>
            <begin position="45"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG05338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="329" mass="37902" checksum="AFF99F4F404445CE" modified="2016-09-07" version="1" fragment="single">MSPIEGDTSSQINGLATPTHDRPSLSKLRVPGVRIEDDERPRGHYVTLSHCWGKAKFTKLTKENLEEFKEGISFSALPSTFRQAIHFARRLSPSIRYIWIDSLCIIQDDKDDWNRESVQMYSVYRNSYCNISATAASDSTHGMHFSRDPHHLWEDEINLNTEGIPRPLDERIPKHHLGLEPLIRRCKIQDASFWDRQVDDAPVNRRAWVLQERLLAPRVLHFCKDQIAWECPHIDAAESHPYGRTRLKALIPGEYGPKTLAIGRTENVYAAHEDWKSIVERYSRTSLTKSNDKLIALAGIAELTSKRMGDRLIYVAGMWEKYLASQLLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CF20</accession>
    <name>A0A177CF20_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pectin lyase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1206744</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG05310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035675.1">
        <property type="nucleotide sequence ID" value="XM_018182050.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CF20"/>
    <dbReference type="STRING" id="1460663.A0A177CF20"/>
    <dbReference type="GeneID" id="28765536"/>
    <dbReference type="InParanoid" id="A0A177CF20"/>
    <dbReference type="OrthoDB" id="187139at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051801">
        <property type="entry name" value="GH28_Enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024535">
        <property type="entry name" value="RHGA/B-epi-like_pectate_lyase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31339">
        <property type="entry name" value="PECTIN LYASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31339:SF9">
        <property type="entry name" value="PLASMIN AND FIBRONECTIN-BINDING PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12708">
        <property type="entry name" value="Pect-lyase_RHGA_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008058121" evidence="1">
        <location>
            <begin position="19"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="domain" description="Rhamnogalacturonase A/B/Epimerase-like pectate lyase" evidence="2">
        <location>
            <begin position="139"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG05310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="515" mass="56215" checksum="1D708977E76FF176" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CF55</accession>
    <name>A0A177CF55_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Amino acid transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_1217497</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG06243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036608.1">
        <property type="nucleotide sequence ID" value="XM_018182896.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CF55"/>
    <dbReference type="STRING" id="1460663.A0A177CF55"/>
    <dbReference type="GeneID" id="28766382"/>
    <dbReference type="InParanoid" id="A0A177CF55"/>
    <dbReference type="OrthoDB" id="3257095at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF4">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="43"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="122"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="166"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="236"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="274"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="310"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="376"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="405"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="439"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="474"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAG06243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="514" mass="57304" checksum="AD7F7BCBC05D293E" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CFV0</accession>
    <name>A0A177CFV0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HET-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1176151</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG06091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036456.1">
        <property type="nucleotide sequence ID" value="XM_018180197.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CFV0"/>
    <dbReference type="STRING" id="1460663.A0A177CFV0"/>
    <dbReference type="GeneID" id="28763683"/>
    <dbReference type="InParanoid" id="A0A177CFV0"/>
    <dbReference type="OrthoDB" id="5125733at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF16">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="2">
        <location>
            <begin position="208"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="649"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="649"/>
            <end position="671"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG06091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="779" mass="88949" checksum="F2245869E423DF3A" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2023-06-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CG96</accession>
    <name>A0A177CG96_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_737699</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG05848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036213.1">
        <property type="nucleotide sequence ID" value="XM_018187240.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CG96"/>
    <dbReference type="GeneID" id="28770726"/>
    <dbReference type="InParanoid" id="A0A177CG96"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG05848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="149" mass="16394" checksum="16AF46CAF2D24A82" modified="2016-09-07" version="1">MRGDARFVSRGLGILSCSRRQAHAAVHDGARAAGICADEIPALDMPSCVKTLNSHNCEGQRERASYPRSLGIVLSHAASSQQWYANASSRAPRIHPRLDALTLPPSSSAYTRLPYVVCRDRKYPPIVGSLFIRFHDCVLGMQEEMLSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CH51</accession>
    <name>A0A177CH51_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_756521</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG06272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036637.1">
        <property type="nucleotide sequence ID" value="XM_018187322.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CH51"/>
    <dbReference type="GeneID" id="28770808"/>
    <dbReference type="InParanoid" id="A0A177CH51"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG06272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="258" mass="28884" checksum="438B30D418801807" modified="2016-09-07" version="1">MVTNATACASSYRTQAPPDMQSAECPYCLSITLGYWHGDDESLSDISSLKQELFHGVCEQCEHASTDSTLILCGWCQHQRLYHIFVCLGRAPSSLTGFRVDPARQLSLNCDYCRLLQQLDARSDTSTNYIGESRSGFNVRFPEGSVGEPHLIGVRPTAFYVHSPALQLRSAETVDWITHSEVHVGSPEAHRYGLVRKVNWELSRQWLSTVLISKPESAESRRGPVRSLIDVRVIDTSRSCIVRLPQDAEYVTLSYVVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CH66</accession>
    <name>A0A177CH66_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Vacuolar protein sorting-associated protein-like protein vps5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CC84DRAFT_1143095</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Golgi apparatus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the sorting nexin family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG06915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037280.1">
        <property type="nucleotide sequence ID" value="XM_018176393.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CH66"/>
    <dbReference type="FunCoup" id="A0A177CH66">
        <property type="interactions" value="759"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CH66"/>
    <dbReference type="GeneID" id="28759879"/>
    <dbReference type="InParanoid" id="A0A177CH66"/>
    <dbReference type="OrthoDB" id="271164at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030904">
        <property type="term" value="C:retromer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045053">
        <property type="term" value="P:protein retention in Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07627">
        <property type="entry name" value="BAR_Vps5p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06861">
        <property type="entry name" value="PX_Vps5p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1520.10:FF:000013">
        <property type="entry name" value="Putative Sorting nexin 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000022">
        <property type="entry name" value="Sorting nexin 3 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035803">
        <property type="entry name" value="BAR_Vps5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037868">
        <property type="entry name" value="PX_Vps5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015404">
        <property type="entry name" value="Vps5_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10555:SF170">
        <property type="entry name" value="FI18122P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10555">
        <property type="entry name" value="SORTING NEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09325">
        <property type="entry name" value="Vps5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PX" evidence="13">
        <location>
            <begin position="186"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="137"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="561"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="472"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="24"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="42"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="110"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="568"/>
            <end position="588"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OAG06915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="603" mass="65456" checksum="74B6BACB20A40981" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CHP2</accession>
    <name>A0A177CHP2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_765586</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG06482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036847.1">
        <property type="nucleotide sequence ID" value="XM_018187363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CHP2"/>
    <dbReference type="GeneID" id="28770849"/>
    <dbReference type="InParanoid" id="A0A177CHP2"/>
    <dbReference type="OrthoDB" id="10421807at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG06482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="156" mass="17875" checksum="A4F6CA0476F234F0" modified="2016-09-07" version="1">MHPGPVKYKLLHARVNRLIGDVLSTILHEQLHQLLGYYICGGDYKNATESQKQLCSYLYVRNVQLFEQVEYQGKRHTYSSYWGHGPAFQVLGRQVESNAFNTLEMRELYETFSLGWISACQCPQGEELCCLSTAAKTTSTRACRRLFSKNWIGKAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CI32</accession>
    <name>A0A177CI32_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7580 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1204378</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG06642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037007.1">
        <property type="nucleotide sequence ID" value="XM_018181901.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CI32"/>
    <dbReference type="STRING" id="1460663.A0A177CI32"/>
    <dbReference type="GeneID" id="28765387"/>
    <dbReference type="InParanoid" id="A0A177CI32"/>
    <dbReference type="OrthoDB" id="5331891at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056002">
        <property type="entry name" value="DUF7580"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35186">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35186:SF4">
        <property type="entry name" value="PRION-INHIBITION AND PROPAGATION HELO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24476">
        <property type="entry name" value="DUF7580"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7580" evidence="2">
        <location>
            <begin position="446"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="283"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="336"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="339"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG06642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="640" mass="71767" checksum="ADA52F598E8111ED" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CIB1</accession>
    <name>A0A177CIB1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tripeptidyl-peptidase II</fullName>
            <ecNumber evidence="4">3.4.14.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CC84DRAFT_1187397</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Secreted tripeptidyl-peptidase which degrades proteins at acidic pHs and is involved in virulence.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of an N-terminal tripeptide from a polypeptide.</text>
            <dbReference type="EC" id="3.4.14.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="15">Binds 1 Ca(2+) ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Secreted</location>
            <location evidence="3">Extracellular space</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.4.14.10" evidence="4"/>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG06527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036892.1">
        <property type="nucleotide sequence ID" value="XM_018180928.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CIB1"/>
    <dbReference type="STRING" id="1460663.A0A177CIB1"/>
    <dbReference type="GeneID" id="28764414"/>
    <dbReference type="InParanoid" id="A0A177CIB1"/>
    <dbReference type="OrthoDB" id="409122at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008240">
        <property type="term" value="F:tripeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04056">
        <property type="entry name" value="Peptidases_S53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11377">
        <property type="entry name" value="Pro-peptidase_S53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.200:FF:000015">
        <property type="entry name" value="Tripeptidyl peptidase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015366">
        <property type="entry name" value="S53_propep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030400">
        <property type="entry name" value="Sedolisin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050819">
        <property type="entry name" value="Tripeptidyl-peptidase_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14218:SF35">
        <property type="entry name" value="PEPTIDASE S53 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14218">
        <property type="entry name" value="PROTEASE S8 TRIPEPTIDYL PEPTIDASE I CLN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09286">
        <property type="entry name" value="Pro-kuma_activ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00944">
        <property type="entry name" value="Pro-kuma_activ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51695">
        <property type="entry name" value="SEDOLISIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11 15" id="KW-0106">Calcium</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 15" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="10 15" id="KW-0720">Serine protease</keyword>
    <keyword evidence="8 16" id="KW-0732">Signal</keyword>
    <keyword evidence="12" id="KW-0843">Virulence</keyword>
    <keyword evidence="13" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008058234" description="tripeptidyl-peptidase II" evidence="16">
        <location>
            <begin position="18"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S53" evidence="17">
        <location>
            <begin position="208"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="15">
        <location>
            <position position="283"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="15">
        <location>
            <position position="287"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="15">
        <location>
            <position position="499"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="540"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="541"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="573"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="575"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="OAG06527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="608" mass="65759" checksum="8C189112E5F2A90C" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CID5</accession>
    <name>A0A177CID5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_1185814</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG06590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036955.1">
        <property type="nucleotide sequence ID" value="XM_018180824.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CID5"/>
    <dbReference type="STRING" id="1460663.A0A177CID5"/>
    <dbReference type="GeneID" id="28764310"/>
    <dbReference type="InParanoid" id="A0A177CID5"/>
    <dbReference type="OrthoDB" id="5376138at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000088">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF3">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="175"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="279"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="322"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="362"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="390"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="423"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="458"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="55"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="7"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAG06590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="515" mass="58015" checksum="0283BEA1B3D8B38E" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CII0</accession>
    <name>A0A177CII0_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_1215708</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG06668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037033.1">
        <property type="nucleotide sequence ID" value="XM_018182739.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CII0"/>
    <dbReference type="STRING" id="1460663.A0A177CII0"/>
    <dbReference type="GeneID" id="28766225"/>
    <dbReference type="InParanoid" id="A0A177CII0"/>
    <dbReference type="OrthoDB" id="3918601at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38794">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38794:SF3">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="57"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="134"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="173"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="208"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="3">
        <location>
            <begin position="40"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="297"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="444"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="444"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="462"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAG06668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="471" mass="52747" checksum="D52C44E4D83059C8" modified="2016-09-07" version="1">MAAVPNKPALHPLTSDDRGSLIIIIAYSWIFITVLAAGIRFGLAWSNRLHLKKDDGTFALGVVLAVASSVCFHIASNNGLGKKMAKVPLDDLDVYYKATYAGEILGLAAQYWAKASFLQLCERVAPRKQKHYNIVFGMVTFWGVFSILAIALQCGLPDPWVFNPEDCPTKGMMYYPVIIMNIITDLILGTWILPTLWKLLMDQDRRILVVMLFGSRIIVACVAAAQLNSVARHILDPDVTYQSFGRVLWALCVTHLSVLQSTIPRTKRFIAALNMRTHATVRLTAFELQLPTDPTTLTIPGKGLDTFDSSEATTSRPDEAHTRSRSPTRKRSDSDRRSSSHSPTRSMQSERPLVPLQLTPSAELYFKTEIVAQPDPAAKDAGRTSKKYDNKDWKKYIRRSRNEDDMALSSMFSWKSRTSTRIVQTKEVTQEVELVHQPKESRWNFRRQSEVSKRNSASGVGQVDGQGQGQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CJD7</accession>
    <name>A0A177CJD7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 7">Arabinan endo-1,5-alpha-L-arabinosidase</fullName>
            <ecNumber evidence="4 7">3.2.1.99</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CC84DRAFT_1163254</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>Endohydrolysis of (1-&gt;5)-alpha-arabinofuranosidic linkages in (1-&gt;5)-arabinans.</text>
            <dbReference type="EC" id="3.2.1.99"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Glycan metabolism; L-arabinan degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the glycosyl hydrolase 43 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.99" evidence="4 7"/>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG06978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037343.1">
        <property type="nucleotide sequence ID" value="XM_018178216.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CJD7"/>
    <dbReference type="STRING" id="1460663.A0A177CJD7"/>
    <dbReference type="GeneID" id="28761702"/>
    <dbReference type="InParanoid" id="A0A177CJD7"/>
    <dbReference type="OrthoDB" id="195678at2759"/>
    <dbReference type="UniPathway" id="UPA00667"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046558">
        <property type="term" value="F:arabinan endo-1,5-alpha-L-arabinosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031222">
        <property type="term" value="P:arabinan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd18831">
        <property type="entry name" value="GH43_AnAbnA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050727">
        <property type="entry name" value="GH43_arabinanases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006710">
        <property type="entry name" value="Glyco_hydro_43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016840">
        <property type="entry name" value="Glyco_hydro_43_endo_a_Ara-ase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43301">
        <property type="entry name" value="ARABINAN ENDO-1,5-ALPHA-L-ARABINOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43301:SF3">
        <property type="entry name" value="ARABINAN ENDO-1,5-ALPHA-L-ARABINOSIDASE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04616">
        <property type="entry name" value="Glyco_hydro_43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF026534">
        <property type="entry name" value="Endo_alpha-L-arabinosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008058283" description="Arabinan endo-1,5-alpha-L-arabinosidase" evidence="10">
        <location>
            <begin position="21"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="36"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="213"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate" evidence="9">
        <location>
            <position position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR026534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OAG06978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="345" mass="37677" checksum="AC12B92C5D07D0A7" modified="2016-09-07" version="1">MNRLPTTILFLLALGTSTVAVPDPICSGLCTGTIRDPAVLRRDDGTWLRFTTEGNLRIATAPSISGPWTSNTGEAGAMLPGGSIIDLDPDQRLWAPNVFFSNGQFYCHYSVSTIGSQNSAIGVATSVTGEPGNWTDHGSIGLPADTRYNRIDANFFRECDTCTPYLNFGSAWEHLFQTTLTSDLLKWSGEAPVHIARNTSFPSVPQTYPSIMEGAFMWWLPNVNGHKYFYLFFSSGACCNTPQSEEGLEAPGDEYKIMVCRGESVTGPFTDKDGRNCLTENGGSLVLGSHGDVYAPGGQGLAHDPDADRVALYYMYVNKADGTYNDFRFGFNWLDFSSGWPEVVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CJT1</accession>
    <name>A0A177CJT1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF1690-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_634908</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG07099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037464.1">
        <property type="nucleotide sequence ID" value="XM_018186971.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CJT1"/>
    <dbReference type="FunCoup" id="A0A177CJT1">
        <property type="interactions" value="54"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CJT1"/>
    <dbReference type="GeneID" id="28770457"/>
    <dbReference type="InParanoid" id="A0A177CJT1"/>
    <dbReference type="OrthoDB" id="5544375at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012471">
        <property type="entry name" value="DUF1690"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07956">
        <property type="entry name" value="DUF1690"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG07099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="192" mass="21916" checksum="A01BC4290DF95154" modified="2016-09-07" version="1">MGAENSKPSSDVSQHVFSSDTPVRFSNGLVDSLQKNTQTDSTRSKQQELQYQQRLTAELEKLREKEAQNLSDLSKTLHVEEPSEPTSLTDRLSDVTEKISDATSSSATLAEKRRQQDMSNSSVTKEIEALRKKLDARKKLEQADPQVNKAKDDVVACLRLHDRRPLDCWKEVEIFKKEVGRLERDFVEKTIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CKE8</accession>
    <name>A0A177CKE8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Synaptobrevin like ykt6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CC84DRAFT_1162005</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Endomembrane system</location>
            <topology evidence="7">Lipid-anchor</topology>
            <orientation evidence="7">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the synaptobrevin family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG07973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038338.1">
        <property type="nucleotide sequence ID" value="XM_018177882.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CKE8"/>
    <dbReference type="FunCoup" id="A0A177CKE8">
        <property type="interactions" value="1218"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CKE8"/>
    <dbReference type="GeneID" id="28761368"/>
    <dbReference type="InParanoid" id="A0A177CKE8"/>
    <dbReference type="OrthoDB" id="27923at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000421">
        <property type="term" value="C:autophagosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033106">
        <property type="term" value="C:cis-Golgi network membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016409">
        <property type="term" value="F:palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061909">
        <property type="term" value="P:autophagosome-lysosome fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042144">
        <property type="term" value="P:vacuole fusion, non-autophagic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd14824">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.50">
        <property type="entry name" value="Longin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010908">
        <property type="entry name" value="Longin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042855">
        <property type="entry name" value="V_SNARE_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45806">
        <property type="entry name" value="SYNAPTOBREVIN HOMOLOG YKT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45806:SF1">
        <property type="entry name" value="SYNAPTOBREVIN HOMOLOG YKT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13774">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00957">
        <property type="entry name" value="Synaptobrevin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01270">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50859">
        <property type="entry name" value="LONGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50892">
        <property type="entry name" value="V_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0488">Methylation</keyword>
    <keyword evidence="4" id="KW-0564">Palmitate</keyword>
    <keyword evidence="6" id="KW-0636">Prenylation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Longin" evidence="9">
        <location>
            <begin position="9"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="V-SNARE coiled-coil homology" evidence="10">
        <location>
            <begin position="144"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00046278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OAG07973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="204" mass="22993" checksum="2E3DD729116F0FC0" modified="2016-09-07" version="1">MSMKCLYMGVWRPNDGGEPVELAHQRELSSFNRFTRGSIQEFLNLFVATAAKKTPPGKRVAIEEDKIPDYLIHTYNNSRGLCGVVVTNKEYPDFVVTGVLKKLTDEFSTKHAASAISSATANSLPYPELKDYITQYQNPQEADKILKIQHELDTTKQVLHQTMESMLERGEKMDQLVAKSNDLSASSKMFYTQAKKQNSCCSVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CL58</accession>
    <name>A0A177CL58_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">PLC-like phosphodiesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1173798</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038649.1">
        <property type="nucleotide sequence ID" value="XM_018180057.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CL58"/>
    <dbReference type="GeneID" id="28763543"/>
    <dbReference type="InParanoid" id="A0A177CL58"/>
    <dbReference type="OrthoDB" id="1046782at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051057">
        <property type="entry name" value="PI-PLC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593:SF143">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-SPECIFIC PHOSPHOLIPASE C X DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG08284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="445" mass="48799" checksum="A137AE136B855816" modified="2016-09-07" version="1">MGWGGCVGIMNASPFIWTQTSQSSYQMNSWSFPGSIDPGQLSTTYIEFDQGIFTTETDTSAVVAFQLNNPSSTEIQIHSEVYRPEDLDNPGNVQNIYVQLNNFPSDQNGQRIDLGFNHDQCVTLYLTSATDSLYANSAPVNWMHATLDLIGDKTLRQIALPGAHDAGMGPDFMSGTAFSVADNTKTQATTIGGQLLQGIRWFDIRPVMGDGGQWLSGHYSDGFAGWQGGNGEPISRVISDVNDFLSQNQELVILELSHSINSDDSYRSLNIAEWNALFDMLVGNISHLYTNPVADLSTIPIRDFIGSGPAVVVVARDDDSVLGDYANHGIHPSSSYRVFNKYSESAKPDYVVSDQISKLQNWKTLEPGDNAFLLSWTETESSVNAVPGFGEGNKANAREINVRLFGSLVPVLTKEVFPNIIIEDYVERKDLASLAMGINFRNHAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CMV0</accession>
    <name>A0A177CMV0_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">AA1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_583624</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038946.1">
        <property type="nucleotide sequence ID" value="XM_018186767.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CMV0"/>
    <dbReference type="STRING" id="1460663.A0A177CMV0"/>
    <dbReference type="GeneID" id="28770253"/>
    <dbReference type="InParanoid" id="A0A177CMV0"/>
    <dbReference type="OrthoDB" id="3928926at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.350.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032382">
        <property type="entry name" value="AltA1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16541">
        <property type="entry name" value="AltA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51895">
        <property type="entry name" value="AA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012655825" description="AA1-like domain-containing protein" evidence="6">
        <location>
            <begin position="16"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="AA1-like" evidence="7">
        <location>
            <begin position="38"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="72"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="130"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAG08581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="153" mass="15648" checksum="119D98014CAA3CA9" modified="2016-09-07" version="1">MQFLTAATLFAAALAAPAPQTSDCPNPAHCGGSAPDPSTYDNVDITDFYLRKNPGIQNAGFTLSGNNGTVQCEIGAVESLPSAVEVCGDSKYRFGLIEATSTGAEVGLRLYRETGPAVGLTGEGDVPTYCHAGGAGAEDFVCQQVSALTIVIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CMZ2</accession>
    <name>A0A177CMZ2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Zf-PARP-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_570108</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038635.1">
        <property type="nucleotide sequence ID" value="XM_018186719.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CMZ2"/>
    <dbReference type="STRING" id="1460663.A0A177CMZ2"/>
    <dbReference type="GeneID" id="28770205"/>
    <dbReference type="InParanoid" id="A0A177CMZ2"/>
    <dbReference type="OrthoDB" id="429950at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1740.10">
        <property type="entry name" value="Zinc finger, PARP-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001510">
        <property type="entry name" value="Znf_PARP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036957">
        <property type="entry name" value="Znf_PARP_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00645">
        <property type="entry name" value="zf-PARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01336">
        <property type="entry name" value="zf-PARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50064">
        <property type="entry name" value="ZF_PARP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PARP-type" evidence="7">
        <location>
            <begin position="3"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="94"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="94"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="158"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="172"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="193"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAG08270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="260" mass="28735" checksum="8AD2287EC67816FA" modified="2016-09-07" version="1">MPYRVEESKNARAGCKNTECKKEGVKIGKGELRFATQVTIQEHTSWAYKHWGCVTPAQVAHLIEESGGDTDMVDGYDELPAELQEKVDFALKNGHVPDEDWKGDIECNRPGQKGFRLTAAQKKKLGKGVEDDEEAPEPKAKRGRAKKEDDDEEGPAPKKARGKGKKAAKQEENEEEAAEEVEAPKPKRGKKAALKDVEEPEPSKAKRSRKAAPKQDVKEDDSAEEPEPPKAKRGKKAAADKAAPQKRSGRKKAAVNYEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CND1</accession>
    <name>A0A177CND1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CBS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1086465</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039161.1">
        <property type="nucleotide sequence ID" value="XM_018174164.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CND1"/>
    <dbReference type="GeneID" id="28757650"/>
    <dbReference type="InParanoid" id="A0A177CND1"/>
    <dbReference type="OrthoDB" id="2536440at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42115">
        <property type="entry name" value="BETA-SYNTHASE (BETA-THIONASE), PUTATIVE (AFU_ORTHOLOGUE AFUA_3G08420)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42115:SF1">
        <property type="entry name" value="BETA-SYNTHASE (BETA-THIONASE), PUTATIVE (AFU_ORTHOLOGUE AFUA_3G08420)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0129">CBS domain</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="33"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG08796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="165" mass="18177" checksum="FC291AB006D02545" modified="2016-09-07" version="1">MSADAPPAAASTANDDYQSLWANKYRGATVEDLEPPPALSCRPTDPISHALMSGLERDYTHLTVTSENRALLGYISIPRLQQLLKEGKVKDSDPVEAAMQKFRRRGTKYKVISLETPLEELEEFFNGGVDGSGKQDFAVVTDGSRKFVLGVATKEDLESFVKRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CPT6</accession>
    <name>A0A177CPT6_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">beta-N-acetylhexosaminidase</fullName>
            <ecNumber evidence="3">3.2.1.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CC84DRAFT_1081819</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.</text>
            <dbReference type="EC" id="3.2.1.52"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 20 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.52" evidence="3"/>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG09534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039899.1">
        <property type="nucleotide sequence ID" value="XM_018173949.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CPT6"/>
    <dbReference type="STRING" id="1460663.A0A177CPT6"/>
    <dbReference type="GeneID" id="28757435"/>
    <dbReference type="InParanoid" id="A0A177CPT6"/>
    <dbReference type="OrthoDB" id="428480at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004563">
        <property type="term" value="F:beta-N-acetylhexosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06564">
        <property type="entry name" value="GH20_DspB_LnbB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.379.10">
        <property type="entry name" value="Chitobiase/beta-hexosaminidase domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025705">
        <property type="entry name" value="Beta_hexosaminidase_sua/sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052764">
        <property type="entry name" value="GH20_Enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015883">
        <property type="entry name" value="Glyco_hydro_20_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029018">
        <property type="entry name" value="Hex-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015882">
        <property type="entry name" value="HEX_bac_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43678:SF1">
        <property type="entry name" value="BETA-N-ACETYLHEXOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43678">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_2G00640)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00728">
        <property type="entry name" value="Glyco_hydro_20"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02838">
        <property type="entry name" value="Glyco_hydro_20b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00738">
        <property type="entry name" value="GLHYDRLASE20"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55545">
        <property type="entry name" value="beta-N-acetylhexosaminidase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008058453" description="beta-N-acetylhexosaminidase" evidence="7">
        <location>
            <begin position="25"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-hexosaminidase bacterial type N-terminal" evidence="9">
        <location>
            <begin position="53"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 20 catalytic" evidence="8">
        <location>
            <begin position="171"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 20 catalytic" evidence="8">
        <location>
            <begin position="336"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR625705-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAG09534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="766" mass="83544" checksum="77003E79E27B660A" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CQM3</accession>
    <name>A0A177CQM3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">tRNA methyltransferas-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CC84DRAFT_1142246</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Required for the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. In the complex, it is required to stabilize and induce conformational changes of the catalytic subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">tRNA modification; N(7)-methylguanine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the WD repeat TRM82 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG09057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039422.1">
        <property type="nucleotide sequence ID" value="XM_018176357.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CQM3"/>
    <dbReference type="STRING" id="1460663.A0A177CQM3"/>
    <dbReference type="GeneID" id="28759843"/>
    <dbReference type="InParanoid" id="A0A177CQM3"/>
    <dbReference type="OrthoDB" id="339900at2759"/>
    <dbReference type="UniPathway" id="UPA00989"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043527">
        <property type="term" value="C:tRNA methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106004">
        <property type="term" value="P:tRNA (guanine-N7)-methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03056">
        <property type="entry name" value="TRM82"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028884">
        <property type="entry name" value="Trm82"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16288:SF0">
        <property type="entry name" value="TRNA (GUANINE-N(7)-)-METHYLTRANSFERASE NON-CATALYTIC SUBUNIT WDR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16288">
        <property type="entry name" value="WD40 REPEAT PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 6" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="2 6 7" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="260"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="150"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="435"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="163"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="451"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAG09057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="482" mass="52652" checksum="7965FD004B0E31B6" modified="2016-09-07" version="1">MISPYQCLAACTRRAADGHEWLLFGATGSDLVVQSSSGVASTWTPEIAAPEEPDREAAQEGPPAKRAKLTPVAEPKPNLSHLKVTKDGKHLVAVSAEDKCIRVFKVGDQCQLVQQSQRCMGKRPSSITLAMDDTTILCADKFGDVYSLPLLPSPEDEQAATPEPKDDQKKFEPSASVLTVHSGRNRKALEEQLKQAQKGAKQVKDTPRFKHHLIIGHVSMLTDVVCAKIGSRSYILTADRDEHIRVSRGIPQTHIIEGFCQGHEEFVSRLCFSKSGRLVSGGGDPYMYIWDWLSFRLIEKIPLQEPLFEHYKGHPHHTGAAEFKVAVSGIWAVPNSAQEILVACEGVPALVSFKLGSSSRTGRVLPLNGNVLDLAFIAVGAGHSIAAVSIDHVHQPGSKHELRQESGASRLQCLSNHNSGEWEDDETLTKALERFSRSMPNGARESGTASETDRGKADNKAKALRDLLYGVENLRKRPGAED</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CQP1</accession>
    <name>A0A177CQP1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DNA repair protein RAD14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CC84DRAFT_1193166</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the XPA family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG09262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039627.1">
        <property type="nucleotide sequence ID" value="XM_018181277.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CQP1"/>
    <dbReference type="FunCoup" id="A0A177CQP1">
        <property type="interactions" value="88"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CQP1"/>
    <dbReference type="GeneID" id="28764763"/>
    <dbReference type="InParanoid" id="A0A177CQP1"/>
    <dbReference type="OrthoDB" id="5368863at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000110">
        <property type="term" value="C:nucleotide-excision repair factor 1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901255">
        <property type="term" value="P:nucleotide-excision repair involved in interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000715">
        <property type="term" value="P:nucleotide-excision repair, DNA damage recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070914">
        <property type="term" value="P:UV-damage excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21077">
        <property type="entry name" value="DBD_Rad14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.530.10:FF:000003">
        <property type="entry name" value="Dna repair rad14 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.530.10">
        <property type="entry name" value="XPA C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000465">
        <property type="entry name" value="XPA/RAD14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022656">
        <property type="entry name" value="XPA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022658">
        <property type="entry name" value="XPA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037129">
        <property type="entry name" value="XPA_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00598">
        <property type="entry name" value="rad14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10142">
        <property type="entry name" value="DNA REPAIR PROTEIN COMPLEMENTING XP-A CELLS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10142:SF0">
        <property type="entry name" value="DNA REPAIR PROTEIN COMPLEMENTING XP-A CELLS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05181">
        <property type="entry name" value="XPA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="Putative DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00753">
        <property type="entry name" value="XPA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="XPA C-terminal" evidence="12">
        <location>
            <begin position="249"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="27"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="64"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00072989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF05181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OAG09262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="408" mass="46346" checksum="6EB7AEDBFBBA2350" modified="2016-09-07" version="1">MAERPSTPPRAMRSAGKLPPNPLTPEQVRRMEEARLRAKAAAQQAQASKPTPPPVAGTKRAYSVINSSNTPATVRNANAASPAKRDQNGFIPPPANDLITPAKNFGRSDFIEYDFSKMTDTKGGFLSTNDDPHNRAMWNGKKEEEKPANMTLAEWERERIRRKLRENRAGIYEPGLSILNQADGRDEEEDALLKAAEEDGEEYKGTYGDGKRDIKGKCRECGSLEIDHKWQDAYHIGICHACKDKFPDKYSLLTKTEAKEDYLLTDPELKDESILPHLERPNPHKSNWQNMQLFLRLQVEHYAFSAAKWGSPAALDEEYEKRQKATKEKKEKKFSKKLKELKKRTRVEAYKRSRMGETEGAGIGAFGQKINTFGDHVHEWGRSVLDHETGLSRKRCEECGMEVEELEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CR14</accession>
    <name>A0A177CR14_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF6590 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_434096</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG09330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039695.1">
        <property type="nucleotide sequence ID" value="XM_018186246.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CR14"/>
    <dbReference type="STRING" id="1460663.A0A177CR14"/>
    <dbReference type="GeneID" id="28769732"/>
    <dbReference type="InParanoid" id="A0A177CR14"/>
    <dbReference type="OrthoDB" id="3559580at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046497">
        <property type="entry name" value="DUF6590"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35391">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35391:SF5">
        <property type="entry name" value="DUF6590 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20233">
        <property type="entry name" value="DUF6590"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6590" evidence="1">
        <location>
            <begin position="9"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6590" evidence="1">
        <location>
            <begin position="242"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG09330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="393" mass="43829" checksum="40C6945F62F51DB2" modified="2016-09-07" version="1">MRTGSEAYNFFRVGKVFSMLHIQAASANELAPISDNITVVKYGERAFSQIRRFVIVEVRRGYVYACPISTYSRRGTLKHGCVPSEHSVVYLSGTAPTTFAGEMEGGLCKEPIAVVPADVSVQMHPASRIHYAKSYPIEMNVKVKDIGDVEPAHLSLILRYYREENSFQDNGSNTSYTTPQYSTSRYPISQNQSTYANSQTSYTYSTPYITPISAHDVSSAVGEDHRGLNIPDTEFEIVHNPKAFFKKGRVFMTPWPEPAGDAVRDQTGPRVSVNIQTFVVIRPQHGHCTCLPINTYGGQGTRKPGVIARDHAAVVAHGDEPPKHSLEPLTKSPIFLKVENESIGPVDPMSRINFAKVYTVEDNMKVRNIGRIVPESIHRMDEYFKESFKFGTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CRN7</accession>
    <name>A0A177CRN7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Spermine synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CC84DRAFT_1160682</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the spermidine/spermine synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG09550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039915.1">
        <property type="nucleotide sequence ID" value="XM_018177555.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CRN7"/>
    <dbReference type="FunCoup" id="A0A177CRN7">
        <property type="interactions" value="996"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CRN7"/>
    <dbReference type="GeneID" id="28761041"/>
    <dbReference type="InParanoid" id="A0A177CRN7"/>
    <dbReference type="OrthoDB" id="38125at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004766">
        <property type="term" value="F:spermidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008295">
        <property type="term" value="P:spermidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.140.10:FF:000001">
        <property type="entry name" value="SPE3p Spermidine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000013">
        <property type="entry name" value="Spermidine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.140.10">
        <property type="entry name" value="Spermidine synthase, tetramerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00198">
        <property type="entry name" value="Spermidine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030374">
        <property type="entry name" value="PABS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030373">
        <property type="entry name" value="PABS_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001045">
        <property type="entry name" value="Spermi_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030668">
        <property type="entry name" value="Spermi_synthase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035246">
        <property type="entry name" value="Spermidine_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037163">
        <property type="entry name" value="Spermidine_synt_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002010">
        <property type="entry name" value="PRK00811.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00417">
        <property type="entry name" value="speE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11558:SF11">
        <property type="entry name" value="SPERMIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11558">
        <property type="entry name" value="SPERMIDINE/SPERMINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17284">
        <property type="entry name" value="Spermine_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01564">
        <property type="entry name" value="Spermine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000502">
        <property type="entry name" value="Spermidine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01330">
        <property type="entry name" value="PABS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51006">
        <property type="entry name" value="PABS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0620">Polyamine biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PABS" evidence="5">
        <location>
            <begin position="11"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAG09550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="291" mass="32921" checksum="3BD9EBA866075C20" modified="2016-09-07" version="1">MSEIVHPTIKDGWFREISDMWPGQAMTLKVKEVLHHEKSKYQDVLIFESTDYGTVLVLDNVIQCTERDEFSYQEMITHLAMNSHPNPKRVLVIGGGDGGVLREVVKHDCVEKAVLCDIDEAVIRLSKKYLPGMSVGFEHPKVEAIVGDGFKYLEDKKGEFDVIITDSSDPEGPAEALFQKPYFELLNGALREGGVITTQAENQWLHMPLIVNLKKGCKEVFPNVEYGYTTIPTYPSGQIGFMVCSKDASLNLKKPLRSWSTEEEEKLCKYYSKEIHEAAFVLPTFARKALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CSN2</accession>
    <name>A0A177CSN2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Adaptin ear-binding coat-associated protein 1 NECAP-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_468848</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040576.1">
        <property type="nucleotide sequence ID" value="XM_018186410.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CSN2"/>
    <dbReference type="STRING" id="1460663.A0A177CSN2"/>
    <dbReference type="GeneID" id="28769896"/>
    <dbReference type="InParanoid" id="A0A177CSN2"/>
    <dbReference type="OrthoDB" id="10265489at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030125">
        <property type="term" value="C:clathrin vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13228">
        <property type="entry name" value="PHear_NECAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000465">
        <property type="entry name" value="Adaptin ear-binding coat-associated protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012466">
        <property type="entry name" value="NECAP_PHear"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12847">
        <property type="entry name" value="ATP-BINDING CASSETTE ABC TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12847:SF9">
        <property type="entry name" value="NECAP-LIKE PROTEIN CG9132"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07933">
        <property type="entry name" value="DUF1681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NECAP PHear" evidence="2">
        <location>
            <begin position="16"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="155"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="221"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="258"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG10211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="269" mass="29244" checksum="381C7766A880CAA2" modified="2016-09-07" version="1">MNTDPLTGEPLPPTAIQRILYLAPKVHVYQIPPLTSTKGYQASSWTADPKRQIFTARLRILETSIPSPTATDDTAEKVSTTLLLEDPSSGQLFAAAPYTAPNVVEQALDSSRFFAITVVGEGRKAVLGMGFEERTEAFDFNIALQDARRALGFEANPNAAAPGRKAASKAAEEPKRDFSLKEGQTISINLGGLKGRRERREGDSKSPEQPKSEQDALFSIKPPPGSGGGFLPPPPSAKSVKEERRRSRQSFEPKPEDLGFDDGEFGEFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CSR8</accession>
    <name>A0A177CSR8_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA polymerase kappa</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_1081999</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040940.1">
        <property type="nucleotide sequence ID" value="XM_018173959.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CSR8"/>
    <dbReference type="STRING" id="1460663.A0A177CSR8"/>
    <dbReference type="GeneID" id="28757445"/>
    <dbReference type="InParanoid" id="A0A177CSR8"/>
    <dbReference type="OrthoDB" id="1747274at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070987">
        <property type="term" value="P:error-free translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042276">
        <property type="term" value="P:error-prone translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03586">
        <property type="entry name" value="PolY_Pol_IV_kappa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.810:FF:000001">
        <property type="entry name" value="DNA polymerase kappa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.810:FF:000003">
        <property type="entry name" value="DNA polymerase kappa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000014">
        <property type="entry name" value="DNA polymerase kappa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.100:FF:000010">
        <property type="entry name" value="DNA-directed polymerase kappa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000039">
        <property type="entry name" value="Polymerase (DNA directed) kappa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1170.60:FF:000012">
        <property type="entry name" value="Putative DNA-directed polymerase kappa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.810">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.100">
        <property type="entry name" value="DNA polymerase, Y-family, little finger domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036775">
        <property type="entry name" value="DNA_pol_Y-fam_lit_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017961">
        <property type="entry name" value="DNA_pol_Y-fam_little_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050116">
        <property type="entry name" value="DNA_polymerase-Y"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022880">
        <property type="entry name" value="DNApol_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001126">
        <property type="entry name" value="UmuC"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002677">
        <property type="entry name" value="PRK02406.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11076:SF33">
        <property type="entry name" value="DNA POLYMERASE KAPPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11076">
        <property type="entry name" value="DNA REPAIR POLYMERASE UMUC / TRANSFERASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00817">
        <property type="entry name" value="IMS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11799">
        <property type="entry name" value="IMS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100879">
        <property type="entry name" value="Lesion bypass DNA polymerase (Y-family), little finger domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50173">
        <property type="entry name" value="UMUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UmuC" evidence="3">
        <location>
            <begin position="123"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="524"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="586"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="17"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="524"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="605"/>
            <end position="615"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00016178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAG10575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="643" mass="72943" checksum="26CC500EE0237AAD" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CST3</accession>
    <name>A0A177CST3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">FAD/NAD(P)-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CC84DRAFT_1161316</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAD-dependent oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040721.1">
        <property type="nucleotide sequence ID" value="XM_018177700.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CST3"/>
    <dbReference type="STRING" id="1460663.A0A177CST3"/>
    <dbReference type="GeneID" id="28761186"/>
    <dbReference type="InParanoid" id="A0A177CST3"/>
    <dbReference type="OrthoDB" id="202203at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004174">
        <property type="term" value="F:electron-transferring-flavoprotein dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43735">
        <property type="entry name" value="APOPTOSIS-INDUCING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43735:SF3">
        <property type="entry name" value="FERROPTOSIS SUPPRESSOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00469">
        <property type="entry name" value="PNDRDTASEII"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="6">
        <location>
            <begin position="11"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAG10356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="422" mass="45767" checksum="52199537AD23AF1C" modified="2016-09-07" version="1">MASKHDLTRKNIIVLGGSYGGISIAHYLLKHVLPALPQRQDHKIIMVSVASEAICRQACPRALISDDLFPQNKLFVSIPKQFEQYPPGEFEFIHGSATVVDHGGRTVTIESYRNGKTQVLTFHSIVVATGASTPSPLLGLNVCDEKNLREAWETFRKGLETAKSIVIAGGGPAGVETAGELGEYLNGRAGFFSSRLESPKVSITVVTSAKNILPYLRPSIAKAAEDHLAKVGVTVIKNNKVVSVNPENVGACRERIASGALLDLSDGTTLQTDLFIPATGFSPNTKFLAKNILDPSTSQVDTNPSTLRVDKAGPRIYAIGDASNYARPAVHSIMAAVPVLGTNMHRDLLLDAGVPENQVPAEKLYKEERRETQLVPIGRSKGVGAAMGWRLPSWMVWLVKGRDYWLWTVGPVWSGKQWAKEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CST6</accession>
    <name>A0A177CST6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Retrograde regulation protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_1082192</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040403.1">
        <property type="nucleotide sequence ID" value="XM_018173968.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CST6"/>
    <dbReference type="GeneID" id="28757454"/>
    <dbReference type="InParanoid" id="A0A177CST6"/>
    <dbReference type="OrthoDB" id="3639251at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000018">
        <property type="entry name" value="MFS transporter permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF47">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="79"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="103"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="138"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="172"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="243"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="274"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="308"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="333"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="367"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="400"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="11"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAG10038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="446" mass="50029" checksum="9174BF0C177A5940" modified="2016-09-07" version="1">MIKRKKVDRRIFPMLCIVFGLSLIDRTNISAAYVAGLGRDLHLDVGSRYNLALLIFCVSYALFDLPSNIIIRRVGARRWLSFLICAWGCIVLGIGFVDDWRFLIVLRTLLGVFEAGILPGAVYIISSWYRQFESAKRMSICIGAAQLFLAFGPVIAYVLSLIRVGDRKFSHGWRWIFLVEGMITIVAGLLSPIFLVDFPEKAGFLTDRQKYIATSRVSLEQEGAHAEHVSFKDSLKILWDWKIGVYCVQHFVVASSIYSLNFFLPIILRDNLGFSYALSQLLCTPPYVFGNILPFVVAYWSDKHKLRWPMLVSQSVSVIIGLLIAMYTKPPGVRYFGIFLAAFGTQANVPATLVYGQNQTAKVQKRAVVAAAMVSAGGLGGICGSLIFRRQDAPWYFPGMWATIALQMLYSIVTICMSMHFTRMNRLADEGKKTSLEGVQGFRYAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CSW8</accession>
    <name>A0A177CSW8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1070058</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040999.1">
        <property type="nucleotide sequence ID" value="XM_018173663.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CSW8"/>
    <dbReference type="GeneID" id="28757149"/>
    <dbReference type="InParanoid" id="A0A177CSW8"/>
    <dbReference type="OrthoDB" id="62952at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038883">
        <property type="entry name" value="AN11006-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085:SF1">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG10634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="215" mass="24649" checksum="A558326CAF1864D8" modified="2016-09-07" version="1" fragment="single">ITPPTNLQLQSPLLRLPAEIKNTIYSYCFDAVEPIVDAIVGCPRPEDGIAPKLGVDILQTCRRVYYEADRRPLFAQNRFRFSTVDRVRCFFRSLDQYELYRDSVKDIEIDARNVHSDHPGIAREWLHYLAWGEGNWGKILGSLRVDAPGLKCLRLNFESWPRIPMFRAELWNLLRSMLMQVEGLERVVIIGASKGRGMIAHAPWSPVHFVGGDDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CUA5</accession>
    <name>A0A177CUA5_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1238447</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG11114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041479.1">
        <property type="nucleotide sequence ID" value="XM_018183940.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CUA5"/>
    <dbReference type="GeneID" id="28767426"/>
    <dbReference type="InParanoid" id="A0A177CUA5"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG11114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="332" mass="38254" checksum="937F7B8CAD473BB7" modified="2016-09-07" version="1">MAPRKPCPPAVARPARTRSVPASFNYRTPTPRVAPPRPGWLHRIAKVRVTVGAAMHAQRRNVVRGLAVLACAYVARNLRAWATQEPSPLVTRWRQHPQWMHTSSSYAVLGLHPPLDPSWVPPYRIVRVAMRKQSAKWHPDNYRENGVDQATARRIWSVFASVLDHFDNFYRNPASMRARWGDHGGLLNPVDTGLPHWNNKTEGAFEALWALFVEMVHAGATPPHRQAKAPQTEAEAALYHPRTWRHVIEGLNPRRSPIPPLGIARYYTCFNNSPSYHPIIVFRRFLSMFALVPTMWSEEEKERWADWLLDVDLAPYHPMWQRFLCGWSMHDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CUE3</accession>
    <name>A0A177CUE3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1161336</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040744.1">
        <property type="nucleotide sequence ID" value="XM_018177707.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CUE3"/>
    <dbReference type="GeneID" id="28761193"/>
    <dbReference type="InParanoid" id="A0A177CUE3"/>
    <dbReference type="OrthoDB" id="5399555at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG10379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="123" mass="13590" checksum="BA58826B6794C233" modified="2016-09-07" version="1">MTKSLESSRPMLASSTGNRASTRMSTYSTAPTLTPSVAPSHLSEASSTAGDPRAQEIKSWNEGFERLEDKRLVQQRYMLNNEKTDNMSKLALGAKLDRALARRMSGQDAVFRPKVLSEKKVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CUK4</accession>
    <name>A0A177CUK4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Biogenesis of lysosome-related organelles complex 1 subunit KXD1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">KxDL homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CC84DRAFT_1224024</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the biogenesis of lysosome-related organelles complex-1 (BLOC-1) involved in endosomal cargo sorting.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the KXD1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG11235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041600.1">
        <property type="nucleotide sequence ID" value="XM_018183535.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CUK4"/>
    <dbReference type="GeneID" id="28767021"/>
    <dbReference type="InParanoid" id="A0A177CUK4"/>
    <dbReference type="OrthoDB" id="4089816at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031083">
        <property type="term" value="C:BLOC-1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007032">
        <property type="term" value="P:endosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032880">
        <property type="term" value="P:regulation of protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051390">
        <property type="entry name" value="BLOC-1_subunit_KXD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019371">
        <property type="entry name" value="KxDL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37787">
        <property type="entry name" value="BIOGENESIS OF LYSOSOME-RELATED ORGANELLES COMPLEX 1 SUBUNIT KXD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37787:SF1">
        <property type="entry name" value="BIOGENESIS OF LYSOSOME-RELATED ORGANELLES COMPLEX 1 SUBUNIT KXD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10241">
        <property type="entry name" value="KxDL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0967">Endosome</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="KxDL" evidence="9">
        <location>
            <begin position="91"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="19"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="60"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF10241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAG11235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="189" mass="20773" checksum="26DE424B66F152E7" modified="2016-09-07" version="1">MSSTHAYYPSYPSGPMPINMPQKGGYYYPHPQHVYGRVSASPPEAPESVTTSGGPSYEPSATSSSYAGSASDYDSSGTTTGVDLMDYMGDRINGSFNPTPLDRSLARQAQTSGELNAKHRELMELQALAQRRLAGARVNFADGMRAAKDVQKDLQWTQKRVDALNNRAARKYPEQYKAAQHRYPAPVDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CUN0</accession>
    <name>A0A177CUN0_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NAD(P)-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1184570</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040945.1">
        <property type="nucleotide sequence ID" value="XM_018180755.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CUN0"/>
    <dbReference type="FunCoup" id="A0A177CUN0">
        <property type="interactions" value="27"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CUN0"/>
    <dbReference type="GeneID" id="28764241"/>
    <dbReference type="InParanoid" id="A0A177CUN0"/>
    <dbReference type="OrthoDB" id="2898509at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052228">
        <property type="entry name" value="Sec_Metab_Biosynth_Oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47534:SF3">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE-LIKE C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47534">
        <property type="entry name" value="YALI0E05731P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG10580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="329" mass="35617" checksum="238DF5898463244B" modified="2016-09-07" version="1">MVDLTTIHASNASLPTHLTAVFVGGTSGIGLYTLLALARRCKVPNIYFIGRSQQAADRILADPHTLNPNGTYTFIPSDVSLIKNVDAVCAQIAARESHINILCLSQGTMSVGQETSEGMHLIASLILHSRIRFTVNLLPLLRAAPGTKRVVSIFTGTKEGPLTAPELQMRTVKSPLKARGQAASAVTLLLEEMGRRAPEVGFVHTYPGFVSSNIGRDFGVVVKGLGWVLERTVGKWLYIPVEESGERNLWLCTSGRFAGAAAGEEKGVEVAVGTDGRAGSGVYTIDEKGESGCEAVLQVLRDMRVQKRDVWAWEEVRKEFLRITGKESM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CUX2</accession>
    <name>A0A177CUX2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1213897</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040952.1">
        <property type="nucleotide sequence ID" value="XM_018182584.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CUX2"/>
    <dbReference type="GeneID" id="28766070"/>
    <dbReference type="InParanoid" id="A0A177CUX2"/>
    <dbReference type="OrthoDB" id="3796690at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="273"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="180"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="225"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="320"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG10587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="400" mass="45237" checksum="65749EE0728EE095" modified="2016-09-07" version="1">MNAPIVALDWLGDMSVPSILPCRTTYLEEGEKEVERSVLNSSFTHYENAPSEEREEDSGTVKRKAPSPERSDARSPIRFDGGRDLLSPGPEVSCLGRRRSGILTGLPIQFEADLEPVRGRSFLRPRIATETFKDPSDASIPRRSIPAATTNPTSIAVQEALRRRDARDVFDVFFSDALRVSPSRSPSPSSSVYSSSTGSEKWMTPPTTQKPTGRCNPVGYRYPSAISQVQPSRSAMNTKTSSPVSPNFSRPLRSVVAQDYSLPPSRKVSFADRNFPWEKDDDDCKPDRRKSSLAERSPLPAPPGQHEKRDFSFEAGLHAQETRFEQKFEGKQRRQARGDIARLATRKREREREQRAIRGSRTSGTDEPKLRQEYQRLRQEMALLREEFRALRQTLVNSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CV17</accession>
    <name>A0A177CV17_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">WD40 repeat-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1113860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG11086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041451.1">
        <property type="nucleotide sequence ID" value="XM_018175374.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CV17"/>
    <dbReference type="STRING" id="1460663.A0A177CV17"/>
    <dbReference type="GeneID" id="28758860"/>
    <dbReference type="InParanoid" id="A0A177CV17"/>
    <dbReference type="OrthoDB" id="5591786at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014839">
        <property type="entry name" value="Crt10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08728">
        <property type="entry name" value="CRT10"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="377"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="444"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="385"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="460"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="473"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG11086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="701" mass="77316" checksum="77B234B451840BA7" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CV41</accession>
    <name>A0A177CV41_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_518691</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG11081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041446.1">
        <property type="nucleotide sequence ID" value="XM_018186590.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CV41"/>
    <dbReference type="GeneID" id="28770076"/>
    <dbReference type="InParanoid" id="A0A177CV41"/>
    <dbReference type="OrthoDB" id="10378476at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG11081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="102" mass="11415" checksum="068D8366FCA4D29B" modified="2016-09-07" version="1">MSTLCHFFAVLRAKAGRARELAMAVRRPRPRMTYPARRRHLQTCGQLRGNPREVRCHRPHTSCISSLPHIPTRTPSCSVEKPDAGVRGGPSLLHFFGCTARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CV71</accession>
    <name>A0A177CV71_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1253916</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG11454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041819.1">
        <property type="nucleotide sequence ID" value="XM_018184414.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CV71"/>
    <dbReference type="STRING" id="1460663.A0A177CV71"/>
    <dbReference type="GeneID" id="28767900"/>
    <dbReference type="InParanoid" id="A0A177CV71"/>
    <dbReference type="OrthoDB" id="3945418at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11062">
        <property type="entry name" value="CYP58-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF166">
        <property type="entry name" value="CYTOCHROME P450 12A4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="2">
        <location>
            <position position="446"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG11454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="503" mass="57622" checksum="4D90FB78C5B4B84B" modified="2016-09-07" version="1">MDQILLCLCFLLAVRAVIVIRRLYFHPLSAYPGTKLGIASPTLYKLYRNFKRRGQFIFEIEQLHQKHGPIVRSGINDLHINDPSIYLQITKIGSRFRKDPKFYDRISFRNTSLGFLDPYQHRARHSILVNAAFSPTPKNIQHLARLVEQKVTKLCDRFDTWAVEGIPVNIHKGMKALSMDVISELTMGRSFGCLDHPTFSNVFLEQLHSIFQEMTWMQKILFTVAKVSLSTPPWMFRFVHPPTMVMMKELAKPLIRDYVDSRKGEVSNEQSLQKAVIIDALTSPSGSKNTKPLDFETLSEEVVTLLTAGGDTVSSALIYGIYHICRNEQVHRKLVEELLTAFPATDDVSYQGAHSLPYLNACIKEILRTGNPLPGRLPRVVPQEGFDLYGRHIPGGCVFNTSAYLLNRHPSIWDRPDDFDPDRWLKSNSGLLEQYMASFYRGTRQCLGKDLAWCELYVMLARLFRQFHVVIHDTSDADMEWIDAVLIVFKGKNLKAMLSRRDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2023-06-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CW07</accession>
    <name>A0A177CW07_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1170159</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG11218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041583.1">
        <property type="nucleotide sequence ID" value="XM_018179839.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CW07"/>
    <dbReference type="GeneID" id="28763325"/>
    <dbReference type="InParanoid" id="A0A177CW07"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="55"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG11218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="116" mass="13238" checksum="0ED2CA2D16B87945" modified="2016-09-07" version="1">MWRGQGEQASRWRGRPRFQQSGARLCKTAAGARVVAVGVSWWIRVLVTKEGEGGAVQSIKEREDKEEQLQEAETAELRKAAKLYREKIQQDKRFAREVAKEAKERERAEKAAQRGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CW96</accession>
    <name>A0A177CW96_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1170235</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG11308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041673.1">
        <property type="nucleotide sequence ID" value="XM_018179844.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CW96"/>
    <dbReference type="GeneID" id="28763330"/>
    <dbReference type="InParanoid" id="A0A177CW96"/>
    <dbReference type="OrthoDB" id="10514289at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008058725" evidence="1">
        <location>
            <begin position="24"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG11308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="114" mass="12923" checksum="DF47B8C9861B1685" modified="2016-09-07" version="1">MRRVLITARCAFLLVLYASLSRAAPLKVGPTAQTVREGLLVRAGLRNHREPGTGLNDRLSVKFPCLRWRLARFCSGGDLPETRWRPRSVQRIVWARFGSLGIRRAPIKDPWAFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CWJ9</accession>
    <name>A0A177CWJ9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Metalloendopeptidase</fullName>
            <ecNumber evidence="1">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1210870</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 1 zinc ion per subunit.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="1"/>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG11197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041562.1">
        <property type="nucleotide sequence ID" value="XM_018182329.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CWJ9"/>
    <dbReference type="STRING" id="1460663.A0A177CWJ9"/>
    <dbReference type="GeneID" id="28765815"/>
    <dbReference type="InParanoid" id="A0A177CWJ9"/>
    <dbReference type="OrthoDB" id="291007at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001506">
        <property type="entry name" value="Peptidase_M12A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127">
        <property type="entry name" value="DISCOIDIN, CUB, EGF, LAMININ , AND ZINC METALLOPROTEASE DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127:SF850">
        <property type="entry name" value="METALLOENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01400">
        <property type="entry name" value="Astacin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00480">
        <property type="entry name" value="ASTACIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033107837" description="Metalloendopeptidase" evidence="1">
        <location>
            <begin position="20"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M12A" evidence="2">
        <location>
            <begin position="216"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU361183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG11197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="427" mass="47638" checksum="295E220FAB2E561C" modified="2016-09-07" version="1">MKLFTQILGCAATTQLVSAIISPIYQPHNFSTGNTSLSTSNHANHTRRYAEYLSSGYSMNLRVSPWPMRSSLWHIDTGYLRTIPYCFVDQRSYEKIGDTGGFCKIRGALGVWAEALNGGADAISGHALGFRFPAKDEGFCCTNYRYGAENQPRADSDFQCDWDHDKWPSDTLAVHWVDEVKSGGIAASATIGYVRTGDPYERPGRHWIRVSDGASPGDIAHEVGHAVGMAHEHQRWDRDDHVEFRCANLVGMSDIINHYRVAAKVDYATASKALCEDQLTAEKWFAPSAEYVRGAGLDVNTKPKFDGPGGFDVDSIMLYDSYSFSKAGYQVNVGTSVLVAIERDADGNKVPGSEKMFPRNTKPSPKDVEFVKTFYPWDAEKYQEYRKAHPEHGDGRKRERDVFSEIILGVIPAHWGCKVEKSKPKLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CX01</accession>
    <name>A0A177CX01_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CC84DRAFT_1134396</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042459.1">
        <property type="nucleotide sequence ID" value="XM_018176022.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CX01"/>
    <dbReference type="FunCoup" id="A0A177CX01">
        <property type="interactions" value="350"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CX01"/>
    <dbReference type="GeneID" id="28759508"/>
    <dbReference type="InParanoid" id="A0A177CX01"/>
    <dbReference type="OrthoDB" id="10252171at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045719">
        <property type="term" value="P:negative regulation of glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14004">
        <property type="entry name" value="STKc_PASK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000320">
        <property type="entry name" value="Serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000314">
        <property type="entry name" value="Serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057213">
        <property type="entry name" value="DUF7891"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF51">
        <property type="entry name" value="PAS DOMAIN-CONTAINING SERINE_THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25421">
        <property type="entry name" value="DUF7891"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="903"/>
            <end position="1162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="29"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="72"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="252"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="439"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="823"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="867"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="36"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="118"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="252"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="284"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="481"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="498"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="867"/>
            <end position="877"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OAG12094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="1169" mass="128014" checksum="E33F2C8AB0A60502" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CXE1</accession>
    <name>A0A177CXE1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Poly(A) RNA polymerase mitochondrial-like central palm domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1064587</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG11389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041754.1">
        <property type="nucleotide sequence ID" value="XM_018173624.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CXE1"/>
    <dbReference type="STRING" id="1460663.A0A177CXE1"/>
    <dbReference type="GeneID" id="28757110"/>
    <dbReference type="InParanoid" id="A0A177CXE1"/>
    <dbReference type="OrthoDB" id="273917at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031499">
        <property type="term" value="C:TRAMP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990817">
        <property type="term" value="F:poly(A) RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010605">
        <property type="term" value="P:negative regulation of macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043634">
        <property type="term" value="P:polyadenylation-dependent ncRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054708">
        <property type="entry name" value="MTPAP-like_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045862">
        <property type="entry name" value="Trf4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23092:SF15">
        <property type="entry name" value="INACTIVE NON-CANONICAL POLY(A) RNA POLYMERASE PROTEIN TRF4-2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23092">
        <property type="entry name" value="POLY(A) RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22600">
        <property type="entry name" value="MTPAP-like_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81631">
        <property type="entry name" value="PAP/OAS1 substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Poly(A) RNA polymerase mitochondrial-like central palm" evidence="1">
        <location>
            <begin position="3"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF22600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG11389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="343" mass="39674" checksum="B90840A6919F838E" modified="2016-09-07" version="1" fragment="single">YRLNREINDFYEYAKPTRAETFARKNLVEQIRADVRARLPNHILEVFGSERTGMALALSDIDLRLVKRDDLDQQASDKPPTPEERRDILRNLYDLRYKVFDNAKTAAKYLQPTVRHARYPLVGVQDRGSGLEVQVVASNDTAKQREYIQRYMKEYPYIRQTYAVIKTMFDQRGLSDVFRGGFGSYPLFMMLVVSLQQQPNQRRDAAGALINFLYYWAYFKTKEKGVSVSPPEYFDKKENPILTETLKAKLDAGTTKPLPNYVLSLRDPADETNDLGRKATSILHAQATLRYLIANIIENLNANNRPSLLAEIVGEVYARDRVRRERLTEHGLWVQKQVLKSFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CXF5</accession>
    <name>A0A177CXF5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Oxysterol binding protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CC84DRAFT_84639</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the OSBP family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042578.1">
        <property type="nucleotide sequence ID" value="XM_018187625.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CXF5"/>
    <dbReference type="FunCoup" id="A0A177CXF5">
        <property type="interactions" value="93"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CXF5"/>
    <dbReference type="GeneID" id="28771111"/>
    <dbReference type="InParanoid" id="A0A177CXF5"/>
    <dbReference type="OrthoDB" id="1854502at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032541">
        <property type="term" value="C:cortical endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097038">
        <property type="term" value="C:perinuclear endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120015">
        <property type="term" value="F:sterol transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035621">
        <property type="term" value="P:ER to Golgi ceramide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001403">
        <property type="term" value="P:invasive growth in response to glucose limitation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000742">
        <property type="term" value="P:karyogamy involved in conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030011">
        <property type="term" value="P:maintenance of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007124">
        <property type="term" value="P:pseudohyphal growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061709">
        <property type="term" value="P:reticulophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd13289">
        <property type="entry name" value="PH_Osh3p_yeast"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000369">
        <property type="entry name" value="Oxysterol binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.160.120:FF:000001">
        <property type="entry name" value="Oxysterol-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.680">
        <property type="entry name" value="GOLD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036598">
        <property type="entry name" value="GOLD_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037239">
        <property type="entry name" value="OSBP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000648">
        <property type="entry name" value="Oxysterol-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041680">
        <property type="entry name" value="PH_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972:SF203">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN HOMOLOG 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01237">
        <property type="entry name" value="Oxysterol_BP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15409">
        <property type="entry name" value="PH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144000">
        <property type="entry name" value="Oxysterol-binding protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101576">
        <property type="entry name" value="Supernatant protein factor (SPF), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="4" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PH" evidence="6">
        <location>
            <begin position="217"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="63"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="159"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="364"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="415"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="439"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="503"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="890"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="172"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="417"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="443"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="547"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="562"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="891"/>
            <end position="912"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAG12213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="993" mass="108815" checksum="98E5F2DB70775BF6" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CXN6</accession>
    <name>A0A177CXN6_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transcription factor IIIC putative zinc-finger domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1253936</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG11479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041844.1">
        <property type="nucleotide sequence ID" value="XM_018184418.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CXN6"/>
    <dbReference type="STRING" id="1460663.A0A177CXN6"/>
    <dbReference type="GeneID" id="28767904"/>
    <dbReference type="InParanoid" id="A0A177CXN6"/>
    <dbReference type="OrthoDB" id="6021743at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000127">
        <property type="term" value="C:transcription factor TFIIIC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004402">
        <property type="term" value="F:histone acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006384">
        <property type="term" value="P:transcription initiation at RNA polymerase III promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044230">
        <property type="entry name" value="GTF3C4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024761">
        <property type="entry name" value="TFIIIC_delta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024764">
        <property type="entry name" value="TFIIIC_Znf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15496:SF2">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15496">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 4 FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12657">
        <property type="entry name" value="TFIIIC_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12660">
        <property type="entry name" value="zf-TFIIIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription factor IIIC 90kDa subunit N-terminal" evidence="1">
        <location>
            <begin position="19"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="domain" description="Transcription factor IIIC putative zinc-finger" evidence="2">
        <location>
            <begin position="655"/>
            <end position="748"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG11479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="750" mass="82721" checksum="E74B95C0BAA0A709" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CXV4</accession>
    <name>A0A177CXV4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CC84DRAFT_41579</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG11657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042022.1">
        <property type="nucleotide sequence ID" value="XM_018186130.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CXV4"/>
    <dbReference type="STRING" id="1460663.A0A177CXV4"/>
    <dbReference type="GeneID" id="28769616"/>
    <dbReference type="InParanoid" id="A0A177CXV4"/>
    <dbReference type="OrthoDB" id="2261376at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046943">
        <property type="term" value="F:carboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030643">
        <property type="term" value="P:intracellular phosphate ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000140">
        <property type="entry name" value="Putative MFS phospholipid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23508">
        <property type="entry name" value="CARBOXYLIC ACID TRANSPORTER PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23508:SF10">
        <property type="entry name" value="CARBOXYLIC ACID TRANSPORTER PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="129"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="172"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="205"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="296"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="328"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="355"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="393"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="431"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="33"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAG11657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="503" mass="54181" checksum="CABA2ECF79147509" modified="2016-09-07" version="1">MSKEAESPSPTADEPRRASISQTEKGRWERLWPVIACGAGLFSDGYLNNIIGPVNTMLSKIYPDEYASSSAQANVSSITFAGTVLGMLFFGYTSDHFSRKWSLFASTIIIILFATLGTGSYGAGGSPKGLLAALVAYRFFLGIGIGGEYPAGSVGCAEGTGELKSGSRNKWFILFTNVQIDLAFFIAAVVATVVVLITGENHLRVAWRVCLGIGIIPPLSLLYLRLKLQEPEAFKRESLAKAKTPWVLVIKFYWQRLIIVSIIWFIYDFSAYSFGIYATTIVNNLLGDEQPLWKSLAWNILINFFYIPGCLAGAFVADLKSMGPKKTLFIGVMLQGIIGFIMAGCYPWLSEPKNIGGFVVVYGVFLMLGEFGPGDNIGLIASKTCATGIRGQYYGIAAAMGKIGAFAGSYALDAIQKNAGDDKIAAGRNPFFVASALAFLAGGLVLLLPHIGQDTIDMEDINFREYLSSHGYDTSKMGLATASDISSEDHVAVETKTVPASVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CY96</accession>
    <name>A0A177CY96_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1170653</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG11810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042175.1">
        <property type="nucleotide sequence ID" value="XM_018179866.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CY96"/>
    <dbReference type="GeneID" id="28763352"/>
    <dbReference type="InParanoid" id="A0A177CY96"/>
    <dbReference type="OrthoDB" id="3800309at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="366"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="369"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG11810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="396" mass="43267" checksum="B1686D9FBC9FECBD" modified="2016-09-07" version="1">MDLNMSDPSLADIAELQRDCHPFPAYIDAMYGRPTEYERLHSNGQDKKPSSSEQAATSNRTTTAPCQHQQTNSLQYSASPAPDPVASLYPSPQSMYAVPPSSFLGNTKASRAPSQTPGGPGKNLQQQQNPSLFSSPMKTTGGDLIGGAPKSQAQSGGALIQNKIGSSPASLYVGDPPPTQLSASTLLEGLASSLAPPLNPASPTSPASPAPIPPVRILLYDDMWKPAFDWMPRQVRTSINDKVGRLRNIIAEEEIMVSTRNQAKVELVALSTQVMEAHKKEILHKMHQAMPSLYDAVLTRHHYPSHHLEHLKANEAIHKIRQQFPGPPQEYMTGLFQEMVRRGKQGKVPYEAIPGWLDQWNIEHAPKATNENAATQKAELEQSNGENSPLPQWRGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CZB6</accession>
    <name>A0A177CZB6_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">type I protein arginine methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.319</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CC84DRAFT_1108007</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-arginyl-[protein] + 2 S-adenosyl-L-methionine = N(omega),N(omega)-dimethyl-L-arginyl-[protein] + 2 S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:48096"/>
            <dbReference type="Rhea" id="RHEA-COMP:10532"/>
            <dbReference type="Rhea" id="RHEA-COMP:11991"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29965"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61897"/>
            <dbReference type="EC" id="2.1.1.319"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:48097"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-arginyl-[protein] + S-adenosyl-L-methionine = N(omega)-methyl-L-arginyl-[protein] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48100"/>
            <dbReference type="Rhea" id="RHEA-COMP:10532"/>
            <dbReference type="Rhea" id="RHEA-COMP:11990"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29965"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65280"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:48101"/>
        </physiologicalReaction>
    </comment>
    <dbReference type="EC" id="2.1.1.319" evidence="1"/>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042394.1">
        <property type="nucleotide sequence ID" value="XM_018175188.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CZB6"/>
    <dbReference type="STRING" id="1460663.A0A177CZB6"/>
    <dbReference type="GeneID" id="28758674"/>
    <dbReference type="InParanoid" id="A0A177CZB6"/>
    <dbReference type="OrthoDB" id="7848332at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042054">
        <property type="term" value="F:histone methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035242">
        <property type="term" value="F:protein-arginine omega-N asymmetric methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000003">
        <property type="entry name" value="Blast:Protein arginine N-methyltransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.160.11">
        <property type="entry name" value="Hnrnp arginine n-methyltransferase1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025799">
        <property type="entry name" value="Arg_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055135">
        <property type="entry name" value="PRMT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11006">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11006:SF123">
        <property type="entry name" value="RIBOSOMAL PROTEIN ARGININE N-METHYLTRANSFERASE RMT3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06325">
        <property type="entry name" value="PrmA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22528">
        <property type="entry name" value="PRMT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51678">
        <property type="entry name" value="SAM_MT_PRMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 7 10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 7 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein arginine N-methyltransferase" evidence="9">
        <location>
            <begin position="305"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="484"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="492"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF22528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAG12029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="508" mass="56711" checksum="2D73158FB4F87B3D" modified="2016-09-07" version="1">MSDTDSDTASSVGEILEDVSEADTTTFKCLFCDEQWSRVPDMFSHCHKEHDFDVENTIKKLGQDIDELSIIKLINYLRLEAQKGIAPKEIKVDSETLADDKYLHPTLPDDALLFELGDFMPDADSKAIDYDEYEAALQKNVGGNVEKLSLDNDRDTDYFESYKGNAIHREMIEDRVRTEGYRDFIEKNAELFKGKTVLDVGCGTGILSLFCARAGAKRVLAVDNSDIANRARDNIARNGFSDKIEVIQGRIEDFHMQRKIGKEKVDIIISEWMGYGLLFEGMLDSVLRARDLYLKEDGLMVPSHCTMRIAPISDKEWIADASGEKFWKDVYGFDFTSMIPGGILNDREIGVFDVPSKSIGGEASTFYELDLKNIQIRDLDFTASFSSKLGSSSASIDAFAIWFDTFFLPGEKSQDATAIDVAKWGNNGEAGLGFSTGPYSTYTHWHQAVLLLGDEDRKKEVKGGSTLKGKVTYKKPRKDDRGIDVTVEWEAESTQGPVSGSSKRTMGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177D040</accession>
    <name>A0A177D040_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CC84DRAFT_1226919</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042897.1">
        <property type="nucleotide sequence ID" value="XM_018183602.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177D040"/>
    <dbReference type="STRING" id="1460663.A0A177D040"/>
    <dbReference type="GeneID" id="28767088"/>
    <dbReference type="InParanoid" id="A0A177D040"/>
    <dbReference type="OrthoDB" id="3352408at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006812">
        <property type="term" value="P:monoatomic cation transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000001">
        <property type="entry name" value="Phospholipid-transporting ATPase IC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42861">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-1278">Translocase</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008058817" evidence="9">
        <location>
            <begin position="27"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="41"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAG12532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="206" mass="22540" checksum="CA766B2DF815CE56" modified="2016-09-07" version="1">MNTGTPLQKKLSKLALLLFGIAYVCALIVEAANKFSGKNEVVIYDLATGLSMIPASLIVVLTITMAVGTKHMSTRNVIFRKLDSLEALGAVTNICSDKTGTLTQGIARGDPTEISIQVIASRFGWNRHGLVGSNDDSDSGAWHCLPEYPFNSDTKHISVLYGRRNSDREKYDSRWVITKGALERVLPLCDFIQDEQGNPRPITDAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177D0D9</accession>
    <name>A0A177D0D9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA polymerase II holoenzyme cyclin-like subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CC84DRAFT_1136511</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cyclin family. Cyclin C subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG13154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018043519.1">
        <property type="nucleotide sequence ID" value="XM_018176104.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177D0D9"/>
    <dbReference type="FunCoup" id="A0A177D0D9">
        <property type="interactions" value="915"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177D0D9"/>
    <dbReference type="GeneID" id="28759590"/>
    <dbReference type="InParanoid" id="A0A177D0D9"/>
    <dbReference type="OrthoDB" id="10266018at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20513">
        <property type="entry name" value="CYCLIN_CCNC_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043198">
        <property type="entry name" value="Cyclin/Ssn8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10026">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028758">
        <property type="entry name" value="Cyclin, C/H/G types"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0195">Cyclin</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="4">
        <location>
            <begin position="53"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin-like" evidence="4">
        <location>
            <begin position="154"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAG13154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="295" mass="33683" checksum="A0CBA876B505C781" modified="2016-09-07" version="1">MASSYWESTQKKFWTFTKPQLALERKRLEDSERNVVNMYPVPDRRHLSIYFYHQLSKMARPLGIRQQALATAQVYVRRFYVKVEIRRTNPALVLATALYLACKMEECPQHIRMVLAEARHCWDTSFNDISKIGECEFTLISEMNSQLIIHHPYRSLAELQSQFQLTQEENSLAWSIINDHYLTDLPLLHAPHVIAITAMFLAVVLKPTQGGLQVHAAGVASALQALGNARGGTGQGMQNRVQKLVDWLAESTVDIEAVVECTQELISLYEIWDSYAEKTCKDQIAKFVKARGLDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177D0G3</accession>
    <name>A0A177D0G3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">tRNA (guanine(10)-N(2))-methyltransferase</fullName>
            <ecNumber evidence="9">2.1.1.214</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CC84DRAFT_1183224</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM11 methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.214" evidence="9"/>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042985.1">
        <property type="nucleotide sequence ID" value="XM_018180675.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177D0G3"/>
    <dbReference type="FunCoup" id="A0A177D0G3">
        <property type="interactions" value="822"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177D0G3"/>
    <dbReference type="GeneID" id="28764161"/>
    <dbReference type="InParanoid" id="A0A177D0G3"/>
    <dbReference type="OrthoDB" id="296065at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043528">
        <property type="term" value="C:tRNA (m2G10) methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160102">
        <property type="term" value="F:tRNA (guanine(10)-N2)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000241">
        <property type="entry name" value="RlmKL-like_Mtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016691">
        <property type="entry name" value="TRMT11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059073">
        <property type="entry name" value="TRMT11_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13370">
        <property type="entry name" value="RNA METHYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13370:SF3">
        <property type="entry name" value="TRNA (GUANINE(10)-N2)-METHYLTRANSFERASE HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25904">
        <property type="entry name" value="Tmrp11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01170">
        <property type="entry name" value="UPF0020"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017259">
        <property type="entry name" value="tRNA_mtfrase_TRM11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51627">
        <property type="entry name" value="SAM_MT_TRM11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 10 14" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 10" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 10 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 10" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="3 10" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="tRNA (guanine(10)-N(2))-methyltransferase TRMT11 N-terminal" evidence="13">
        <location>
            <begin position="3"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal RNA large subunit methyltransferase K/L-like methyltransferase" evidence="12">
        <location>
            <begin position="177"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="456"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00066937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF25904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OAG12620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="484" mass="54319" checksum="590EDBAB305D75EB" modified="2016-09-07" version="1">MPNYLVRLVQMHESFRQAELQALADVAEVSIEFVKYEEESPFCIVRLPSDAAAKTVISRSLLSQGIYELWGQGATYDALHESVKDISSAKWVQYESAPFRFTLDCFRGTRDNAQQRDIIESFSYMGFKGPIRMRDAEASFKVFEEYEEKATGPKYAYLGRFVAASGRDAKTTYDLKKRHYISTTSMDAELALVTANMALAAPGKLFYDPFMGTGGFPIACAHFGAMVCGSDIDGRSIRGTGGSARKGQTGKFDVQGNFKQYGLESRYLGAFVSDLTNTPFRLLQHSNSASRGGYLDGIVCDPPYGIREGLKVLGSRDILNEQERATHGNRYKDPGYIPPKKPYSFTAIQDDILAFAVSTLVENGRLSMWMPTANDEDVELIIPTHPCLEIVSVCVQTFNKWSRRLLTYRRRAESEVPEGALETVKKEYEKGVKADELNNFRKKYFEGFKEFERLRQEPSAEDANHKADRSKGVSGPWREKSGAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177D0Y4</accession>
    <name>A0A177D0Y4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CC84DRAFT_1079430</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG13121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018043486.1">
        <property type="nucleotide sequence ID" value="XM_018173848.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177D0Y4"/>
    <dbReference type="STRING" id="1460663.A0A177D0Y4"/>
    <dbReference type="GeneID" id="28757334"/>
    <dbReference type="InParanoid" id="A0A177D0Y4"/>
    <dbReference type="OrthoDB" id="4131217at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43180">
        <property type="entry name" value="3-OXOACYL-(ACYL-CARRIER-PROTEIN) REDUCTASE (AFU_ORTHOLOGUE AFUA_6G11210)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43180:SF66">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAG13121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="313" mass="33169" checksum="C27FD723F24583F5" modified="2016-09-07" version="1">MPADPKVKQQGLSRELSEGPQDPGMFEDIPRVREIAGDLGSQRVKDKVIIITGCNSPIGIGRASAHQFARNGAKAVYICDFASTHLDTHKRELGALYPAVDIHTRVFDAADEAAVKHVCQEALDTYGRLDVFFANAGISSAKVFWEEDTQGFMNMMRVNTLSVFLAAKHASRAMLKTSTHKPYPQGAIIATASVAGLRSNAGPTDYSASKAAVVSLMQTCAFQLAGTGIRCNAVCPGLIETGMTKTTYDAARARGSTGKIGQLNPLRRGGVADEIARAVLFLGSDEASYVNGQAWAVDGGLSAGHPFVPGKLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177D1B7</accession>
    <name>A0A177D1B7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">SET domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CC84DRAFT_1078143</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG13017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018043382.1">
        <property type="nucleotide sequence ID" value="XM_018173788.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177D1B7"/>
    <dbReference type="STRING" id="1460663.A0A177D1B7"/>
    <dbReference type="GeneID" id="28757274"/>
    <dbReference type="InParanoid" id="A0A177D1B7"/>
    <dbReference type="OrthoDB" id="308383at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042054">
        <property type="term" value="F:histone methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050973">
        <property type="entry name" value="H3K9_Histone-Lys_N-MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003616">
        <property type="entry name" value="Post-SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007728">
        <property type="entry name" value="Pre-SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46223:SF3">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SET-23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46223">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SUV39H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05033">
        <property type="entry name" value="Pre-SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50868">
        <property type="entry name" value="POST_SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="SET" evidence="8">
        <location>
            <begin position="179"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="Post-SET" evidence="9">
        <location>
            <begin position="329"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAG13017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="346" mass="39399" checksum="191B4C52C793A966" modified="2016-09-07" version="1">MLRVARMSKIETANILIRAEYIRRLSKVAGKKIHLVNVHDYTTPSLRFQYIPEYVLREGVFRADSATQEGCQQCSPHMGRNIGCEYTKKCGCLEYAAVDVNRITTAEMKQKYENALATGGSTLGFPKKFPYFTDGTKRQRTGTLVPFYLDSRHPIYECNDNCRCGPYCRNKNVQFGRQVELEIFKTGSGRGWGLRCKEDLFVGQFIDTYRGEVITDAEATRREQAGGQLKASYLYSLDKHQESEGLAQEEIYVVDGEFMGGPSKFMNHSCAPNCRQYTVSYNKHDNRIYDLAFFAIRDVPAGEELTFDYLDKEEGEGEGEGEEEEPPDGAVPCLCGAEKCRRWLWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177D2B2</accession>
    <name>A0A177D2B2_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CC84DRAFT_1136526</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG13159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018043524.1">
        <property type="nucleotide sequence ID" value="XM_018176105.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177D2B2"/>
    <dbReference type="STRING" id="1460663.A0A177D2B2"/>
    <dbReference type="GeneID" id="28759591"/>
    <dbReference type="InParanoid" id="A0A177D2B2"/>
    <dbReference type="OrthoDB" id="10029320at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF232">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAG13159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="385" mass="44489" checksum="9EB631F84DE4AFD8" modified="2016-09-07" version="1">MILQRRQTIHTTKNPSECAQIISGSILKGDTNLLSKYEARAQPNQRLRPAFGIDNAFTTDHSERHKEYRNKVGTMLRPDWNMVASAAKRLAKNECPKNLVNLVQSFVLKMTINVLFRHDFPSLDDESISLVASEINDIWIGSKLPRHIVPWSKQDRLHDALRLLVPNRDPLDPQRNAMNFILPAFETMWRIVLRCFIEVRYRGAEETEEWIAALKLFLENPTVRLEDSHEGASEIEKAISIVREALRLYPPTRHIHRHFRFASGSSILAIADIEGLHRDTAIWGFDADCFRPSRWANMRHEPEPFNAWMPFGSSPFLCPAKPDFGPRMIGILVAALVDAFSDVRYELNVRDPRGQKESAKFYGLLRSDRDSYKELFLEKVDRRCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BTW7</accession>
    <name>A0A177BTW7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">glycerophosphodiester phosphodiesterase</fullName>
            <ecNumber evidence="2">3.1.4.46</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CC84DRAFT_427548</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a sn-glycero-3-phosphodiester + H2O = an alcohol + sn-glycerol 3-phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12969"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:83408"/>
            <dbReference type="EC" id="3.1.4.46"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycerophosphoryl diester phosphodiesterase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.46" evidence="2"/>
    <dbReference type="EMBL" id="KV441564">
        <property type="protein sequence ID" value="OAF98853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029219.1">
        <property type="nucleotide sequence ID" value="XM_018186190.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BTW7"/>
    <dbReference type="STRING" id="1460663.A0A177BTW7"/>
    <dbReference type="GeneID" id="28769676"/>
    <dbReference type="InParanoid" id="A0A177BTW7"/>
    <dbReference type="OrthoDB" id="1058301at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008889">
        <property type="term" value="F:glycerophosphodiester phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006071">
        <property type="term" value="P:glycerol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.190:FF:000040">
        <property type="entry name" value="Glycerophosphoryl diester phosphodiesterase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030395">
        <property type="entry name" value="GP_PDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43620:SF7">
        <property type="entry name" value="GLYCEROPHOSPHODIESTER PHOSPHODIESTERASE GDPD5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43620">
        <property type="entry name" value="GLYCEROPHOSPHORYL DIESTER PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03009">
        <property type="entry name" value="GDPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51704">
        <property type="entry name" value="GP_PDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0319">Glycerol metabolism</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008057403" description="glycerophosphodiester phosphodiesterase" evidence="7">
        <location>
            <begin position="17"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="GP-PDE" evidence="8">
        <location>
            <begin position="67"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAF98853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="408" mass="45026" checksum="E68AA32E7F4383E1" modified="2016-09-07" version="1">MHSVVALTLLATSAIAFPSNGYSTGHGSSKLNIQVGDRPYYLINNMDDGPLKTKLQSCSEGPFKPSDFVVSHRGASLQFPEHTTEGLAAARRQGAGILECDVAFTKDKKLVCRHAQCDLHTTTNILNTTLASKCTTPFQPAANGQPAKAKCCTSDITQAEFKTLCAKMDGFNPNGTTVASYMDGTPYFRTDLYATCGTLMTLNEYISIVDSYGLKFTPELKTPEIPMPYDGYTQTQYAQDMIDAFKKAKIDPERVYAQSFLPDDIFYWIKHEPEFGKQAVYLDSRVDTPAGYANATASIPDLAKKGVKIMAPAFFALTKVDPVTKKVVPSEYAIAVKKAGMDIITWSFERSGWLNRGGDYYYQYVKDVINNDGDMYTVLDVLAQQVKIRGMFADWPASVTYYANCFGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BU90</accession>
    <name>A0A177BU90_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Sec20-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CC84DRAFT_1191473</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the SEC20 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441563">
        <property type="protein sequence ID" value="OAF98992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029358.1">
        <property type="nucleotide sequence ID" value="XM_018181184.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BU90"/>
    <dbReference type="STRING" id="1460663.A0A177BU90"/>
    <dbReference type="GeneID" id="28764670"/>
    <dbReference type="InParanoid" id="A0A177BU90"/>
    <dbReference type="OrthoDB" id="46868at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005606">
        <property type="entry name" value="Sec20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056173">
        <property type="entry name" value="Sec20_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12825">
        <property type="entry name" value="BNIP1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12825:SF0">
        <property type="entry name" value="VESICLE TRANSPORT PROTEIN SEC20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03908">
        <property type="entry name" value="Sec20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="243"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="273"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="Sec20 C-terminal" evidence="13">
        <location>
            <begin position="174"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="144"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="302"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="56"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="147"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="400"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF03908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OAF98992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="451" mass="50035" checksum="69F0E1E033AADD5C" modified="2016-09-07" version="1">MPPLPPTTQTLTTRLTTLSDSNKAVQQLIQRLAKLDFQPGSQPLSAEEGDIRLELSAEIHESLKGVEEDLELLRQEVEDFVGTGSSGRRRDSVRDGERSRLAVLLARLTEDLRSSRAQYRKAQLTAKHNADRAKLKERELLFSNLQSGTGSSTPSSTHRRRGNGLNESEIVTQASSDVTAALRRTHQLMQSELSRSRFAQETLEQSTAALADLGEKYSDLNTLLANSKTLVTTLLKSQKSDTWYLETTFYILITTVIWLVFRRWLYGPISWFILLPLKILFRIVFAVIPVSAATSSVSANPSTSLIVKPSATGGIPPRQPGQNYVRVGGGGRGYAGNPPDPSPPSSLSHSVGKMAEQSQKQQGAQDVPDHPQLRKHNNPALEEEDEGPVVRGDGTVLPARGEDKPRNPKKKMWEESVENKAFEERQKEAEREILGSQDEAEKEGERKRDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BV71</accession>
    <name>A0A177BV71_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PHF5-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_389813</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PHF5 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441562">
        <property type="protein sequence ID" value="OAF99292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029658.1">
        <property type="nucleotide sequence ID" value="XM_018186016.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BV71"/>
    <dbReference type="FunCoup" id="A0A177BV71">
        <property type="interactions" value="921"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177BV71"/>
    <dbReference type="GeneID" id="28769502"/>
    <dbReference type="InParanoid" id="A0A177BV71"/>
    <dbReference type="OrthoDB" id="10248186at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005684">
        <property type="term" value="C:U2-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009410">
        <property type="term" value="P:response to xenobiotic stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005345">
        <property type="entry name" value="PHF5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13120">
        <property type="entry name" value="PHD FINGER-LIKE DOMAIN-CONTAINING PROTEIN 5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03660">
        <property type="entry name" value="PHF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016468">
        <property type="entry name" value="PHF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAF99292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="108" mass="12239" checksum="BDEC4C3AD2CF956F" modified="2016-09-07" version="1">MSRHHPDLVMCRKQAGISIGRLCDKCDGKCPVCDSYVRPTTLARICDECSFGNYQNKCVVCGGEGISDAFYCFECTRLEKDRDGCPKIINLGSSRTDLFYQKKNFRNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BVT2</accession>
    <name>A0A177BVT2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1132278</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441564">
        <property type="protein sequence ID" value="OAF98778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029144.1">
        <property type="nucleotide sequence ID" value="XM_018175929.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BVT2"/>
    <dbReference type="GeneID" id="28759415"/>
    <dbReference type="InParanoid" id="A0A177BVT2"/>
    <dbReference type="OrthoDB" id="3694387at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAF98778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="271" mass="31404" checksum="100C737D32E3472C" modified="2016-09-07" version="1" fragment="single">MASNNTMTNTTTNTTTNTTINTTINSNYALVLTELVDAVNHIFDPKFDVPATHIKFLDFPPEVRAKIIDYSLLGDLESGTLTKAMHHDSFYNPCCVWNWPDQLIVCDKAKESDLPNTMFPKWLPHLSLTNHQMRGEVLVHMLKTTDCITLKYNKDLAIKIAPRFIKFLRTFPANEGFEADRNLNFPHIHWYNYNNDGKTLASNPDVDLMLACPKLERVGLTWHYKRINFLHPYEEYWTPMTLDRFLSWWKLSPMLGCDNLKHVYIGGIHAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BW13</accession>
    <name>A0A177BW13_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_392999</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441562">
        <property type="protein sequence ID" value="OAF99305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029671.1">
        <property type="nucleotide sequence ID" value="XM_018186020.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BW13"/>
    <dbReference type="FunCoup" id="A0A177BW13">
        <property type="interactions" value="380"/>
    </dbReference>
    <dbReference type="GeneID" id="28769506"/>
    <dbReference type="InParanoid" id="A0A177BW13"/>
    <dbReference type="OrthoDB" id="809632at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016628">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05288">
        <property type="entry name" value="PGDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000121">
        <property type="entry name" value="Prostaglandin reductase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041694">
        <property type="entry name" value="ADH_N_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045010">
        <property type="entry name" value="MDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43205:SF19">
        <property type="entry name" value="ENOYL REDUCTASE (ER) DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43205">
        <property type="entry name" value="PROSTAGLANDIN REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16884">
        <property type="entry name" value="ADH_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="2">
        <location>
            <begin position="25"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAF99305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="355" mass="38906" checksum="2BC8CB6413D0C51C" modified="2016-09-07" version="1">MSPIPKQTRQWIVSNPPKTNVSLSGDDATFKLQTVDTPSITDGQVLVKLKYLSNDPAQRGWIQDGADAERLYVPPVRQGDVMRSFGIGEIVQSKAENLKEGQLVSYMANWTDYRVLEAKEATPIQEDKEAGIKATHFIGALGGPGLTAYYGLVKVAEAKAEDTVVVSGAAGSTGSMVVQIAKHVLGCKRVIGIAGGAEKCSWVESLGADVCVDYKAADFEEKLIKATDGYVEVYFDNVGGHILDTMLKRIKRYGRVAVCGSIATYNDPESTNLKNWFEVIANRIELKGFIVFDAYLKGNGQEMVDTVRNAVKDKKIQIEKQEETIVPTKFEDIPKTWTMLFEGGNKGKLVTELTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BWB6</accession>
    <name>A0A177BWB6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_1103668</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441561">
        <property type="protein sequence ID" value="OAF99594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029960.1">
        <property type="nucleotide sequence ID" value="XM_018175024.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BWB6"/>
    <dbReference type="STRING" id="1460663.A0A177BWB6"/>
    <dbReference type="GeneID" id="28758510"/>
    <dbReference type="InParanoid" id="A0A177BWB6"/>
    <dbReference type="OrthoDB" id="47007at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05362">
        <property type="entry name" value="THN_reductase-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48107">
        <property type="entry name" value="NADPH-DEPENDENT ALDEHYDE REDUCTASE-LIKE PROTEIN, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48107:SF7">
        <property type="entry name" value="RE15974P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAF99594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="268" mass="28652" checksum="23E78B242EDE6C8A" modified="2016-09-07" version="1">MANASYPSWSLEGKVAVVTGSGRGIGKEMALELARRGCSVAVNYANAKEAAEEVVKQIEGMKTGAKAVAIKANVADVKQTQYLMDEVVKQFGKLDICCSNSGVVSFGHFKDVEEAEYDRVMQINTRGQFFVAKEAYKRMSVGGRIILMGSITGQAKGVPKHAVYSGSKGAIETFTRCMAIDAGEKKVTVNCVAPGGIKTDMYHAVCREYIPNGENLSDDEVDVYAATWSPVGRVGQPLDIARVVCFLASQDGDWVNGKVIGIDGAACM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BWL3</accession>
    <name>A0A177BWL3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Small ribosomal subunit protein uS15 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CC84DRAFT_1264616</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS15 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441563">
        <property type="protein sequence ID" value="OAF99068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029434.1">
        <property type="nucleotide sequence ID" value="XM_018185321.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BWL3"/>
    <dbReference type="FunCoup" id="A0A177BWL3">
        <property type="interactions" value="908"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177BWL3"/>
    <dbReference type="GeneID" id="28768807"/>
    <dbReference type="InParanoid" id="A0A177BWL3"/>
    <dbReference type="OrthoDB" id="623277at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070181">
        <property type="term" value="F:small ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00353">
        <property type="entry name" value="Ribosomal_S15p_S13e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.10:FF:000003">
        <property type="entry name" value="40S ribosomal protein S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.860.130:FF:000001">
        <property type="entry name" value="40S ribosomal protein S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.10">
        <property type="entry name" value="S15/NS1, RNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01343_A">
        <property type="entry name" value="Ribosomal_uS15_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000589">
        <property type="entry name" value="Ribosomal_uS15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023029">
        <property type="entry name" value="Ribosomal_uS15_arc_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012606">
        <property type="entry name" value="Ribosomal_uS15_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009068">
        <property type="entry name" value="uS15_NS1_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006331">
        <property type="entry name" value="PRK08561.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11885">
        <property type="entry name" value="RIBOSOMAL PROTEIN S15P/S13E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11885:SF6">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08069">
        <property type="entry name" value="Ribosomal_S13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00312">
        <property type="entry name" value="Ribosomal_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01386">
        <property type="entry name" value="Ribosomal_S13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01387">
        <property type="entry name" value="Ribosomal_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47060">
        <property type="entry name" value="S15/NS1 RNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00362">
        <property type="entry name" value="RIBOSOMAL_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS15 N-terminal" evidence="5">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAF99068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="151" mass="16816" checksum="0A6598FDFED31C30" modified="2016-09-07" version="1">MGRLHSNGKGISSSAIPYSRTAPAWLKTTPEQVVEQICKLARKGATPSQIGEVLRDSHGVAQTKIVTGNKVLRILKSNGLAPEIPEDLYMLIKKAVAVRKHLQTNRKDRDGKFRLILIESRIHRLSRYYKTVGVLPPTWRYESATASTLVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BX23</accession>
    <name>A0A177BX23_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Integral membrane protein-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1104949</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441563">
        <property type="protein sequence ID" value="OAF98926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029292.1">
        <property type="nucleotide sequence ID" value="XM_018175075.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BX23"/>
    <dbReference type="STRING" id="1460663.A0A177BX23"/>
    <dbReference type="GeneID" id="28758561"/>
    <dbReference type="InParanoid" id="A0A177BX23"/>
    <dbReference type="OrthoDB" id="4159154at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051285">
        <property type="term" value="C:cell cortex of cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009571">
        <property type="entry name" value="SUR7/Rim9-like_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052413">
        <property type="entry name" value="SUR7_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28019">
        <property type="entry name" value="CELL MEMBRANE PROTEIN YLR413W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28019:SF7">
        <property type="entry name" value="SUR7 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06687">
        <property type="entry name" value="SUR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008057408" evidence="2">
        <location>
            <begin position="20"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="179"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="212"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="257"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAF98926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="295" mass="31499" checksum="7162695C313421E3" modified="2016-09-07" version="1">MRPSALIPALLSAAALVLAFLCLFAGHKKNFMEDYSILTLNTSRLGEGVVNGTLGNSDSTLGSLWDLVPDSIQNDVSEAAGVVTEKLGIEDFYSAHLLDYCYGQYTPTEAANATVSAGDIHKNVTGCSNQTAMFYFNPTQIIEDALNKSGLDVTLDDLEWPADIQRGLDTLRVVSITAFVLYCISIGLIFLSFIAALVAVFTSGRLSACVNLLLGILAFLAIGLASALVTAVIEKGGDIINEHGKDIGLEAGKGKKFMALTWVSTGCMFLVLVMWCVETCVGRRRKGAYVNGKHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BXB8</accession>
    <name>A0A177BXB8_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1209814</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441560">
        <property type="protein sequence ID" value="OAG00154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030519.1">
        <property type="nucleotide sequence ID" value="XM_018182244.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BXB8"/>
    <dbReference type="STRING" id="1460663.A0A177BXB8"/>
    <dbReference type="GeneID" id="28765730"/>
    <dbReference type="InParanoid" id="A0A177BXB8"/>
    <dbReference type="OrthoDB" id="2744543at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052523">
        <property type="entry name" value="Trichothecene_AcTrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791">
        <property type="entry name" value="GNAT FAMILY ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791:SF1">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13508">
        <property type="entry name" value="Acetyltransf_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="142"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG00154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="228" mass="25347" checksum="17B34955489121B2" modified="2016-09-07" version="1">MTDCISIHPATLPDIPTLAAIRTEAAESSLLTHFQFSPYHNIAAEKESDALVTRLSKRFTDPDGQKFHLIKAVDSRNEETVGWGLVKWEDGSWVNAGAPSSAQAVAPDEEVGPTNPGSFGRYWSRHVIAKWREITGGKPHVTIGAMNVKIAWQGQGIGRMMVDYMYREYGLKNNMVIVQTTASAEKFYQKMGWETVDSTDIDLSDWAGKGMGYGLLRCPQMVKYSWGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BXP8</accession>
    <name>A0A177BXP8_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">glucan endo-1,3-beta-D-glucosidase</fullName>
            <ecNumber evidence="4">3.2.1.39</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_1104811</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of (1-&gt;3)-beta-D-glucosidic linkages in (1-&gt;3)-beta-D-glucans.</text>
            <dbReference type="EC" id="3.2.1.39"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell envelope</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 17 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.39" evidence="4"/>
    <dbReference type="EMBL" id="KV441562">
        <property type="protein sequence ID" value="OAF99468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029834.1">
        <property type="nucleotide sequence ID" value="XM_018175072.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BXP8"/>
    <dbReference type="STRING" id="1460663.A0A177BXP8"/>
    <dbReference type="GeneID" id="28758558"/>
    <dbReference type="InParanoid" id="A0A177BXP8"/>
    <dbReference type="OrthoDB" id="77201at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042973">
        <property type="term" value="F:glucan endo-1,3-beta-D-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050732">
        <property type="entry name" value="Beta-glucan_modifiers"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16631">
        <property type="entry name" value="GLUCAN 1,3-BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16631:SF13">
        <property type="entry name" value="GLUCAN ENDO-1,3-BETA-GLUCOSIDASE EGLC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008057433" description="glucan endo-1,3-beta-D-glucosidase" evidence="7">
        <location>
            <begin position="19"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="414"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAF99468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="444" mass="48077" checksum="6B8F4107327F5055" modified="2016-09-07" version="1" fragment="single">MVFATVLLLLQLLIPAASFTVDDIHTGFNYGAFWGTPDKPKRKGDYGYAFRAAKSLNSSVAFDSPRLFTCRQPGTTDEYIEAFDAAVEMHTYLLLGFYVSEMNKSAQIPRQSYETNADMLKYELRALEKALAHHGRALADLIIGLSVGNEDMESLYSDAVTTVVSENVITSNIATVQNAVLGSAFGWDKLFKTLPPIGHADTARNAAVQNADFIGANIFPFWHSDPSEKARASFNESLQEVKKRDGKAPVWIREAGWPSAGKGTTVSLKNMQKYWSTVVCSLIDRYTIFSFELKKDSHDPGDLDWGLIEKSSQKPKISDLSCLGSPDFPSLPPLAGLSTSHTITPISAPMNTSTFLATSLTSVPNGYMSVQHVDPLTSPLTSVFASQDRASSNSGSTTHITITSTITAYAAPSNSVSQEGTSQPASSSFSETHVTITSTITVPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BXZ0</accession>
    <name>A0A177BXZ0_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">Cutinase</fullName>
            <ecNumber evidence="3 12">3.1.1.74</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CC84DRAFT_1232677</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the hydrolysis of complex carboxylic polyesters found in the cell wall of plants. Degrades cutin, a macromolecule that forms the structure of the plant cuticle.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 12">
            <text>cutin + H2O = cutin monomers.</text>
            <dbReference type="EC" id="3.1.1.74"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the cutinase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.74" evidence="3 12"/>
    <dbReference type="EMBL" id="KV441562">
        <property type="protein sequence ID" value="OAF99266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029632.1">
        <property type="nucleotide sequence ID" value="XM_018183770.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BXZ0"/>
    <dbReference type="STRING" id="1460663.A0A177BXZ0"/>
    <dbReference type="GeneID" id="28767256"/>
    <dbReference type="InParanoid" id="A0A177BXZ0"/>
    <dbReference type="OrthoDB" id="2975078at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050525">
        <property type="term" value="F:cutinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000675">
        <property type="entry name" value="Cutinase/axe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043580">
        <property type="entry name" value="CUTINASE_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043579">
        <property type="entry name" value="CUTINASE_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011150">
        <property type="entry name" value="Cutinase_monf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48250:SF2">
        <property type="entry name" value="CUTINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48250">
        <property type="entry name" value="CUTINASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01083">
        <property type="entry name" value="Cutinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00129">
        <property type="entry name" value="CUTINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01110">
        <property type="entry name" value="Cutinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00155">
        <property type="entry name" value="CUTINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00931">
        <property type="entry name" value="CUTINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 12" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="6 12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007948919" description="Cutinase" evidence="12">
        <location>
            <begin position="19"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="10">
        <location>
            <position position="130"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="182"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="10">
        <location>
            <position position="195"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="41"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="178"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR611150-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR611150-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OAF99266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="213" mass="21463" checksum="A9E132203E287204" modified="2016-09-07" version="1">MKISFITVLAAALSVTSAAPAIEKRQYSSSTYNQLTDGTACRPISVIYARGTGQQGNVGDSQAVGPLFFNNLASRVGGTSQLAIQGVTYSASIAGFLAGGDSAGTTTMTNLISQTASRCPNTKIVLSGYSQGAQLVHNAAQKTSAANAAKVAAVVVFGDPKKGQSLGSIASSKVLTICHSGDNICEGGASITPAHLNYQNDVGTAGAFVAGKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BXZ5</accession>
    <name>A0A177BXZ5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NAD-P-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CC84DRAFT_1169035</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441560">
        <property type="protein sequence ID" value="OAG00195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030560.1">
        <property type="nucleotide sequence ID" value="XM_018179555.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BXZ5"/>
    <dbReference type="STRING" id="1460663.A0A177BXZ5"/>
    <dbReference type="GeneID" id="28763041"/>
    <dbReference type="InParanoid" id="A0A177BXZ5"/>
    <dbReference type="OrthoDB" id="1933717at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44196">
        <property type="entry name" value="DEHYDROGENASE/REDUCTASE SDR FAMILY MEMBER 7B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44196:SF1">
        <property type="entry name" value="DEHYDROGENASE_REDUCTASE SDR FAMILY MEMBER 7B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoreductase" evidence="4">
        <location>
            <begin position="38"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAG00195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="302" mass="33205" checksum="7FBF5537B54349F8" modified="2016-09-07" version="1">MSTNPKSQLQSSGVDFTPTIHHDTYDYIKPQQFDLKNRAVFITGASKGIGRATAISYAKAGASQIAIAARTDMKEVEAEMMAAAKDAGKSAPQVLRLQVDVTDDRSVQDAAKQIEQTFGRLDVLINNAGYLEKFVPLHESEIDEWWKVWEVNIKGVYLITRALLPLLLKSKDSLRTILNVSSIGANIIMPGASGYQAGKLALLRFGEFLNADYADQGILAFGIHPGGIATELAKGMPEAMHSMLTDTEELAGDSIVWLTAERREWIKGRYVSCNWDMKEFLAKRAAIEDGDLLKVRLDVGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BY84</accession>
    <name>A0A177BY84_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Arabinanase/levansucrase/invertase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CC84DRAFT_1231526</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 43 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441560">
        <property type="protein sequence ID" value="OAG00096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030461.1">
        <property type="nucleotide sequence ID" value="XM_018183731.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BY84"/>
    <dbReference type="STRING" id="1460663.A0A177BY84"/>
    <dbReference type="GeneID" id="28767217"/>
    <dbReference type="InParanoid" id="A0A177BY84"/>
    <dbReference type="OrthoDB" id="2139957at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09001">
        <property type="entry name" value="GH43_FsAxh1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041542">
        <property type="entry name" value="GH43_C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006710">
        <property type="entry name" value="Glyco_hydro_43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051795">
        <property type="entry name" value="Glycosyl_Hydrlase_43"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42812">
        <property type="entry name" value="BETA-XYLOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42812:SF15">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G00930)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17851">
        <property type="entry name" value="GH43_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04616">
        <property type="entry name" value="Glyco_hydro_43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008057483" evidence="5">
        <location>
            <begin position="18"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-xylosidase C-terminal Concanavalin A-like" evidence="6">
        <location>
            <begin position="336"/>
            <end position="543"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF17851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAG00096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="546" mass="59740" checksum="DDCE24D3827F8352" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BYD3</accession>
    <name>A0A177BYD3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HET-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1103976</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441561">
        <property type="protein sequence ID" value="OAF99701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030067.1">
        <property type="nucleotide sequence ID" value="XM_018175037.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BYD3"/>
    <dbReference type="STRING" id="1460663.A0A177BYD3"/>
    <dbReference type="GeneID" id="28758523"/>
    <dbReference type="InParanoid" id="A0A177BYD3"/>
    <dbReference type="OrthoDB" id="2157530at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF73">
        <property type="entry name" value="HET DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_8G01020)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="54"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAF99701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="134" mass="15169" checksum="7ABF5D9E9A43C8DE" modified="2016-09-07" version="1" fragment="single">MSTSPGTDSSSPYQTPTRHSGTNYIRLIKLLPGSPESPIACTLHELELEKPGEFTALSYTWGKPDPTFEITLNGRQIQVRENLCSFLKQARELGRSELLWIDVISINQDNIEERNHQVALMGQVYRRAAKVVVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BYP7</accession>
    <name>A0A177BYP7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">beta-N-acetylhexosaminidase</fullName>
            <ecNumber evidence="3">3.2.1.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CC84DRAFT_1263455</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.</text>
            <dbReference type="EC" id="3.2.1.52"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 20 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.52" evidence="3"/>
    <dbReference type="EMBL" id="KV441559">
        <property type="protein sequence ID" value="OAG00493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030858.1">
        <property type="nucleotide sequence ID" value="XM_018185241.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BYP7"/>
    <dbReference type="STRING" id="1460663.A0A177BYP7"/>
    <dbReference type="GeneID" id="28768727"/>
    <dbReference type="InParanoid" id="A0A177BYP7"/>
    <dbReference type="OrthoDB" id="428480at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004563">
        <property type="term" value="F:beta-N-acetylhexosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06564">
        <property type="entry name" value="GH20_DspB_LnbB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.379.10">
        <property type="entry name" value="Chitobiase/beta-hexosaminidase domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025705">
        <property type="entry name" value="Beta_hexosaminidase_sua/sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052764">
        <property type="entry name" value="GH20_Enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015883">
        <property type="entry name" value="Glyco_hydro_20_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029018">
        <property type="entry name" value="Hex-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015882">
        <property type="entry name" value="HEX_bac_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43678:SF1">
        <property type="entry name" value="BETA-N-ACETYLHEXOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43678">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_2G00640)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00728">
        <property type="entry name" value="Glyco_hydro_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02838">
        <property type="entry name" value="Glyco_hydro_20b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00738">
        <property type="entry name" value="GLHYDRLASE20"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55545">
        <property type="entry name" value="beta-N-acetylhexosaminidase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-hexosaminidase bacterial type N-terminal" evidence="8">
        <location>
            <begin position="95"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 20 catalytic" evidence="7">
        <location>
            <begin position="201"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR625705-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAG00493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="741" mass="81877" checksum="342785F675F57FD4" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BYX8</accession>
    <name>A0A177BYX8_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">SP-RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CC84DRAFT_326459</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein sumoylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NSE2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441560">
        <property type="protein sequence ID" value="OAF99898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030264.1">
        <property type="nucleotide sequence ID" value="XM_018185859.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BYX8"/>
    <dbReference type="STRING" id="1460663.A0A177BYX8"/>
    <dbReference type="GeneID" id="28769345"/>
    <dbReference type="InParanoid" id="A0A177BYX8"/>
    <dbReference type="OrthoDB" id="756301at2759"/>
    <dbReference type="UniPathway" id="UPA00886"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030915">
        <property type="term" value="C:Smc5-Smc6 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061665">
        <property type="term" value="F:SUMO ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016925">
        <property type="term" value="P:protein sumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16651">
        <property type="entry name" value="SPL-RING_NSE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026846">
        <property type="entry name" value="Nse2(Mms21)"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004181">
        <property type="entry name" value="Znf_MIZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21330">
        <property type="entry name" value="E3 SUMO-PROTEIN LIGASE NSE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21330:SF1">
        <property type="entry name" value="E3 SUMO-PROTEIN LIGASE NSE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11789">
        <property type="entry name" value="zf-Nse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51044">
        <property type="entry name" value="ZF_SP_RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SP-RING-type" evidence="13">
        <location>
            <begin position="301"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="163"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="271"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="396"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="109"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="14"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="163"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="412"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="428"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OAF99898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="459" mass="51333" checksum="BBAFF3B4B5DA3A30" modified="2016-09-07" version="1">MSSRHSRSGARPTPSRSSIVSLQTSPRRPAVEEELPPYRKPSHPLNEQALTKLRALNGPSVTQLKDHNKKAADRVTNAAALVLDTLFERQAAVAKKRAKWDNNIGTGSREQDEARLAELQAQVDEFSKKLEESMRAIIDNSVAAQRIEESLAWLQTHAPGQLQQYTTRGSQQQSQRASQRASGSQGRRTQTRDDDDEDMQDEHETQVSMGPTPGPTPLDGSRPTLTGVSEMYTERVERGKRDYTSMSYGGRYARNKEYSTFKKMVHDAQYRDDRPLPNPETWFTETGEPALGVTGRGEDHDDDDIVMERATISIKCPLTFLPYKDPYTSSKCPHTFERNAIMEMIRTSNVRVGGGSANTGEKAVKCPVTGCDQMLRMHDLNHDPVLARRIKRLQEDKAREAEQSDEEEDRQVSVSQQPTQSVQPRIKVSSSSRLQVPSAQETPRGSIVDDLGSSGEEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BZ38</accession>
    <name>A0A177BZ38_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1221926</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441559">
        <property type="protein sequence ID" value="OAG00416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030781.1">
        <property type="nucleotide sequence ID" value="XM_018183314.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BZ38"/>
    <dbReference type="GeneID" id="28766800"/>
    <dbReference type="InParanoid" id="A0A177BZ38"/>
    <dbReference type="OrthoDB" id="3773917at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="396"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG00416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="460" mass="52056" checksum="30553ABE28C7D2FD" modified="2016-09-07" version="1">MSSANTDSTIDSIVFEMRQHHALRSRLYTSPRLPTYQSFLDQLRDLDTGSLTPGAYCPICRVPFSESQTISSNAGSEYQYGLALETLPFHIEDSHALIDSPVRLPCASQHIVGKACIVTWATEGGGTTCPLDREELFILGAEDTFSVTDDEHRFNTGLRAIEKLPIRQLLVRFRAATESGIVRVNARAMTKRLATLIFRIVFETHGVPEAATLRWKWPRIGRPLYGYNEASAFRSVVKQWVDGEPLEEDGGYPRHIVTLLNPALPHVFALLYRLARFFQARSMSLDELACAMQQHMHVFFKDFAYVVTDEKVLRSITFKTIDIWTTQELLVTQLRTATNQPDEWAGIVGPRDRPVTPYFGLRGRGRIGYWHFNRESERERRERRATLGEAAGLLVYDDDEDVPQGESGRERPGVSRSPDLGASVRPWSPLSGETEEEFTLLTSGIIINDRRNPRGLREEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BZ99</accession>
    <name>A0A177BZ99_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1102621</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441559">
        <property type="protein sequence ID" value="OAG00713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031078.1">
        <property type="nucleotide sequence ID" value="XM_018174973.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BZ99"/>
    <dbReference type="STRING" id="1460663.A0A177BZ99"/>
    <dbReference type="GeneID" id="28758459"/>
    <dbReference type="InParanoid" id="A0A177BZ99"/>
    <dbReference type="OrthoDB" id="9451547at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35043">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35043:SF7">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="217"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="287"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="319"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="353"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG00713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="396" mass="44383" checksum="CF692E829090F6CF" modified="2016-09-07" version="1" fragment="single">IMIFHPNCTLPGSSPVFVSAPNVRSTTEILWNCLSTVFLCTWSILFLNIPPQTKPKTTSKHLNLLWTKVKWMITTLLALELIIGFAASSFWSARSTTETLKNLALDDVVDWSIAHTCYADMGGSVIRFEETSAIETAETTDKQRYFGLGNVWVLNPRQLRRAREFGVITRLPLLSEDELGDKDKGDNLVKTLDLVQIMLMLAQLISRRLKDRPVSQLGVMTLSFAACAVIIYLPVLPSPQGVETPTVNLGRRASFDEMRSIAKAQSISIIMRSLYTIPNDICHHKEAFVVGTGLGAIWFGVLHLIAWDFTFPAAVERKLWRVSSVVTIISPMSSLAFGLIVVCFGWVDHKFAARTWATFSSFSIAAFIVARIFLLVESFRSLYYQPVDVFVSTWAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BZC6</accession>
    <name>A0A177BZC6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1222075</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441559">
        <property type="protein sequence ID" value="OAG00575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030940.1">
        <property type="nucleotide sequence ID" value="XM_018183328.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BZC6"/>
    <dbReference type="GeneID" id="28766814"/>
    <dbReference type="InParanoid" id="A0A177BZC6"/>
    <dbReference type="OrthoDB" id="3771551at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="212"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG00575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="267" mass="29388" checksum="3ED604D53C81B914" modified="2016-09-07" version="1">MAPNLVPIEANGPLSAAKFDVVPSAMHDRLQTDFEHACSKYTKAAVEAPAASYGTQYEIKKALIYIIPKHEPEITTIQTGFAFAESANIGLIGLVIDNRAINFAELCASQCDSSSAEQQRAHPGFLECHAVDSGALSWGIDAFGCLSLCILVQGEAHELRREAYFVQRVYARGEDGPRAGGLSKSSEQESAPRSGFSFSMKLPDAVVKGKIKAKEAEDEDRLDRMMEAGPPQSKKPELPELSWEEYQAEFWRSHGGKPNYERTTKRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BZE5</accession>
    <name>A0A177BZE5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CC84DRAFT_1154264</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441558">
        <property type="protein sequence ID" value="OAG00904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031269.1">
        <property type="nucleotide sequence ID" value="XM_018176875.1"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177BZE5"/>
    <dbReference type="GeneID" id="28760361"/>
    <dbReference type="InParanoid" id="A0A177BZE5"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18580">
        <property type="entry name" value="ABC_6TM_ABCC_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000838">
        <property type="entry name" value="ABC multidrug transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044726">
        <property type="entry name" value="ABCC_6TM_D2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056227">
        <property type="entry name" value="TMD0_ABC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF399">
        <property type="entry name" value="ABC TRANSPORTER ATNG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24357">
        <property type="entry name" value="TMD0_ABC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="64"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="99"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="128"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="157"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="259"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="309"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="383"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="407"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="487"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="875"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="926"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1009"/>
            <end position="1040"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1100"/>
            <end position="1128"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="276"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="603"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="892"/>
            <end position="1167"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="1203"/>
            <end position="1447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="827"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="835"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="856"/>
            <end position="865"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OAG00904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="1452" mass="160455" checksum="6D93AE8BC317BF89" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BZF5</accession>
    <name>A0A177BZF5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_1190056</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441558">
        <property type="protein sequence ID" value="OAG00763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031128.1">
        <property type="nucleotide sequence ID" value="XM_018181096.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BZF5"/>
    <dbReference type="GeneID" id="28764582"/>
    <dbReference type="InParanoid" id="A0A177BZF5"/>
    <dbReference type="OrthoDB" id="3360610at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004493">
        <property type="term" value="F:methylmalonyl-CoA epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046491">
        <property type="term" value="P:L-methylmalonyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07267">
        <property type="entry name" value="THT_Oxygenase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.180.10:FF:000034">
        <property type="entry name" value="Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.180.10:FF:000039">
        <property type="entry name" value="Trihydroxytoluene oxygenase (AFU_orthologue AFUA_8G02470)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="entry name" value="2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051785">
        <property type="entry name" value="MMCE/EMCE_epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43048">
        <property type="entry name" value="METHYLMALONYL-COA EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43048:SF3">
        <property type="entry name" value="METHYLMALONYL-COA EPIMERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="3">
        <location>
            <begin position="205"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAG00763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="365" mass="40837" checksum="02917ED83CFDA60C" modified="2016-09-07" version="1">MAFEDLQEKITPNQPSREASPARGASVPQDAAIPSERMSLREWQASQKIDRDAQVKITKLSHMRYQHPDLAEITTFLRDFGMSVAQKAEGKRWFKGYGTDQYVYYAQEGEKRFLGGAFEVESYAELEKATRIPGASAIQDLSDAPGGGHMVTIIDPGNFPINLLYGQTPKPAGPMPSILQTNYEVQKPRVATFQRFSPGPAAVHKLGHYGLCVTNFPEQLAFYTGYFNLVPTDFLYVDDGEAGKKDVAAFLHIDVGPAYTDHHTFFMSSNPTAHVHHCSFEVHDFDSQNLGHEWLAKKGYKSVWGVGRHILGSQLFDYWWDTSGNMVEHYADGDLVNEETPVGWGEAGHESLAVWGPECPKWFLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BZT7</accession>
    <name>A0A177BZT7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Acetyl-CoA hydrolase</fullName>
            <ecNumber evidence="4">3.1.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Acetyl-CoA deacylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CC84DRAFT_1101022</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>acetyl-CoA + H2O = acetate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20289"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="3.1.2.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the acetyl-CoA hydrolase/transferase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.1" evidence="4"/>
    <dbReference type="EMBL" id="KV441558">
        <property type="protein sequence ID" value="OAG00893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031258.1">
        <property type="nucleotide sequence ID" value="XM_018174893.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BZT7"/>
    <dbReference type="FunCoup" id="A0A177BZT7">
        <property type="interactions" value="200"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177BZT7"/>
    <dbReference type="GeneID" id="28758379"/>
    <dbReference type="InParanoid" id="A0A177BZT7"/>
    <dbReference type="OrthoDB" id="10250396at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008775">
        <property type="term" value="F:acetate CoA-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003986">
        <property type="term" value="F:acetyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006083">
        <property type="term" value="P:acetate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.750.70:FF:000002">
        <property type="entry name" value="Acetyl-CoA hydrolase Ach1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1080.10:FF:000003">
        <property type="entry name" value="Acetyl-coA hydrolase Ach1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1080.20:FF:000001">
        <property type="entry name" value="Acetyl-CoA hydrolase Ach1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.70">
        <property type="entry name" value="4-hydroxybutyrate coenzyme like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1080.20">
        <property type="entry name" value="Acetyl-CoA hydrolase/transferase C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1080.10">
        <property type="entry name" value="Glutaconate Coenzyme A-transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026888">
        <property type="entry name" value="AcetylCoA_hyd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038460">
        <property type="entry name" value="AcetylCoA_hyd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046433">
        <property type="entry name" value="ActCoA_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003702">
        <property type="entry name" value="ActCoA_hydro_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43609">
        <property type="entry name" value="ACETYL-COA HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43609:SF1">
        <property type="entry name" value="ACETYL-COA HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13336">
        <property type="entry name" value="AcetylCoA_hyd_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02550">
        <property type="entry name" value="AcetylCoA_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acetyl-CoA hydrolase/transferase N-terminal" evidence="9">
        <location>
            <begin position="13"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="Acetyl-CoA hydrolase/transferase C-terminal" evidence="10">
        <location>
            <begin position="333"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OAG00893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="540" mass="59970" checksum="B19DB6FF72A2D877" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BZX4</accession>
    <name>A0A177BZX4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_311590</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441559">
        <property type="protein sequence ID" value="OAG00541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030906.1">
        <property type="nucleotide sequence ID" value="XM_018185819.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BZX4"/>
    <dbReference type="GeneID" id="28769305"/>
    <dbReference type="InParanoid" id="A0A177BZX4"/>
    <dbReference type="OrthoDB" id="10534172at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG00541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="240" mass="26613" checksum="D63862C4A27310B2" modified="2016-09-07" version="1">MGESPKGVSLGVLGALAPCRRASSSTQCECALHHQLPVASHIALVDCCWYCWRWRCSRHCNACPLTTRTIGLQVFCAARQSLSMIIVWTQPPSCPATYKLLKPNRTAPNGDSKQSAACCMFPKVLDDAVGCRRGHPRAMARIRYALAIRRSSISGSGRFCHGSWKIARTSSLRPNDWLERLNDMRDLAAPAHCEEVGQCSRAARRRLRTVLRCWVDARILFRAKAPLAVAQCIVLSPPWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C0P5</accession>
    <name>A0A177C0P5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Dehydroquinate synthase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_1167588</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441557">
        <property type="protein sequence ID" value="OAG01364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031729.1">
        <property type="nucleotide sequence ID" value="XM_018179211.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C0P5"/>
    <dbReference type="STRING" id="1460663.A0A177C0P5"/>
    <dbReference type="GeneID" id="28762697"/>
    <dbReference type="InParanoid" id="A0A177C0P5"/>
    <dbReference type="OrthoDB" id="339764at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08192">
        <property type="entry name" value="MAR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1090.10">
        <property type="entry name" value="Dehydroquinate synthase-like - alpha domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001670">
        <property type="entry name" value="ADH_Fe/GldA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056798">
        <property type="entry name" value="ADH_Fe_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018211">
        <property type="entry name" value="ADH_Fe_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039697">
        <property type="entry name" value="Alcohol_dehydrogenase_Fe"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11496">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11496:SF97">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE IRON-TYPE_GLYCEROL DEHYDROGENASE GLDA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25137">
        <property type="entry name" value="ADH_Fe_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00465">
        <property type="entry name" value="Fe-ADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56796">
        <property type="entry name" value="Dehydroquinate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00060">
        <property type="entry name" value="ADH_IRON_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA" evidence="2">
        <location>
            <begin position="20"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="Fe-containing alcohol dehydrogenase-like C-terminal" evidence="3">
        <location>
            <begin position="185"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAG01364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="378" mass="40386" checksum="4EA5CBF122A9BB1F" modified="2016-09-07" version="1">MTDATSHPLSGLWASTQISKLYYGPSTVSKHLLDCLPSKSSKAFIITGNSLATKTPLVKQVEELLGAQHAGTFSNIGEHAPVAQLDEATEMVQKDEKIDTVLSIGGGSPIDSAKAISYRVHEKSGKWMFHIAIPTTLSASECTMMAGFTQADGVKTGVRAVELVPNVVLYDASFASHTPERLWLSTGMRALDHAVELLYHPTAPEMPARWTCLQAAASLFEGLKAYKGGSRDEDTLTKLQLAAFASLGFLGTNLKGGLGLSHGLGYALGSPYGIPHGITSCLTLGHVVKLKAAAPEAAEQIARLLPFLGESKSGDDKKDAEKVGQRILDLVQDLGLDSDLRNYKVDKDQIPVITKRATGQEEGGELYGKVQKLVEGLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C0S7</accession>
    <name>A0A177C0S7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1263244</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441558">
        <property type="protein sequence ID" value="OAG01243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031608.1">
        <property type="nucleotide sequence ID" value="XM_018185223.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C0S7"/>
    <dbReference type="GeneID" id="28768709"/>
    <dbReference type="InParanoid" id="A0A177C0S7"/>
    <dbReference type="OrthoDB" id="4627814at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024532">
        <property type="entry name" value="DUF3830"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12903">
        <property type="entry name" value="DUF3830"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG01243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="143" mass="15799" checksum="F17D7B2130ABA3DB" modified="2016-09-07" version="1">MADNDTILITAGPYQFLAKFESNAPKTVNVFRGLLPYRKQLIHVRWSGEGLWVPLGDENLGINFENHTTHPSTGQILLYPGGYSETELLFCYGGVSFASKMGPLAANHFLTIVEGMENLKALGELILWKGAHDVLFETTDSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C0Y9</accession>
    <name>A0A177C0Y9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PCI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CC84DRAFT_277666</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CSN7/EIF3M family. CSN7 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV441558">
        <property type="protein sequence ID" value="OAG01155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031520.1">
        <property type="nucleotide sequence ID" value="XM_018185733.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C0Y9"/>
    <dbReference type="STRING" id="1460663.A0A177C0Y9"/>
    <dbReference type="GeneID" id="28769219"/>
    <dbReference type="InParanoid" id="A0A177C0Y9"/>
    <dbReference type="OrthoDB" id="10265275at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008180">
        <property type="term" value="C:COP9 signalosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045237">
        <property type="entry name" value="COPS7/eIF3m"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15350:SF5">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15350">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 7/DENDRITIC CELL PROTEIN GA17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22061">
        <property type="entry name" value="CSN7_HB_subdom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0736">Signalosome</keyword>
    <feature type="domain" description="PCI" evidence="4">
        <location>
            <begin position="2"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="221"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="221"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="234"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAG01155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="270" mass="29326" checksum="13C60F3220D2333E" modified="2016-09-07" version="1">MEQTKALNALEPFLALSKSASSPRAASDLVTQATSAPNTFVFAELIHTPNIQKLRESQEYATYLTLLEIFAWGTWTDYKGRTDLPKLSEKQHEKLLMLSLLPLARSHATLTYPALMSALDLPTPRALEQLLTTAIYAGLLTATLDPAHSVVSVTSVAPLRDLAPGSLPALQATLASWSNRCDSALQDLELRVAEVRKAAVEREMLRRKKERALEVMLSLSEDKGKGGGKARDEGYEDAMDIDDQGGSGRQTRGTKRGFAGGFSGLGKRLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C124</accession>
    <name>A0A177C124_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_294795</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441559">
        <property type="protein sequence ID" value="OAG00320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030685.1">
        <property type="nucleotide sequence ID" value="XM_018185777.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C124"/>
    <dbReference type="STRING" id="1460663.A0A177C124"/>
    <dbReference type="GeneID" id="28769263"/>
    <dbReference type="InParanoid" id="A0A177C124"/>
    <dbReference type="OrthoDB" id="5428259at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="465"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG00320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="488" mass="55388" checksum="1B8E71FD29CCC3E2" modified="2016-09-07" version="1">MASANIPLHCSICPKRPNFSDVSHLLTHIASKGHLSNYYKVKVRSGNDDAARRLVESYDRWYSEWNVEDLMSERMTQKDKRRSRARPVARQTPTPKIEAPIPRLARPRTAVGNLLDPRLSEQQLIKLESAVSSTPTPQPGPVLRQRPPRLFGAHMQYWTGTDSRASSRSYTNDYDTSSEYSDPSERRRYQSVTREDSCAIEDDPTDAGSADPMAVSESTKLKGVLWPGMAIFDSATPEMRRKRNQKKDSSVVEQLEINSQEVEPTELIFTPTGSFKRQRRISSSVYDDEEDEMVKVESPTPSLARPALADLDVNASRRQRPVTRAQPFYAACSSYEDEHSQSDRANSYGDRAPKRKRRFEVFQDNEVSFGQPAPFQTLTAGFQHQVSPTPAPTVPLFKNFNQNPFQFEPRIENKENMPPMLHHGSAYEHHHAHQPAAFHYQAFTYGLAPEHPAIQYQNQLYMPMHGYHPSQDDDDSRTITAPPSPSTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C1C2</accession>
    <name>A0A177C1C2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CC84DRAFT_1101272</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441558">
        <property type="protein sequence ID" value="OAG01011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031376.1">
        <property type="nucleotide sequence ID" value="XM_018174906.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C1C2"/>
    <dbReference type="GeneID" id="28758392"/>
    <dbReference type="InParanoid" id="A0A177C1C2"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000090">
        <property type="entry name" value="MFS sugar transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF37">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="51"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="80"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="110"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="139"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="177"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="263"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="304"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="328"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="361"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="398"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="430"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="12"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAG01011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="505" mass="55398" checksum="72437AF349F7490A" modified="2016-09-07" version="1">MALPPKWYQFLVGVFASLGSLLFGYDLGVIAQVVASPSFAKEFNNPKANETGAVVSVFTGGAFLGAGVAGVLADRIGRRLTIMIGAIIFCLGGALQTGAMALSYLYSGRAIAGLGVGVLTMIIPLYQAELAHPSIRGRITALQQFMLGVGALAAAWISYGTYTGFAPDDNGQWRTSLGIQILPAVVLAALILLFPESPRWLIDQGKTEEGLRTLAKLHSHGNIDDAWVRAEFDQIQETITYEHEHEASSIGELFTDRSSFRRLFLACAIQASVQMTGVSAIQYYSPAIYKLMGIATNDTLKYQAISSILALIAQATCILFIDRFGRRWPLICGNLFNMVTFIIATVLLAKFPPGANDNKSAAWAFIVITWLYNVSFSATNGPLSWIIPAEIFDTKTRAYGVMIATMTSFAFNTMIGQITPIAMENVGYKFYILFVVGNFTNAIFFWAFLPETAKRPLEEMKYLFTEAPLFVPGMKRVDFETHDLEHRVQEVEAKQGYSSHVETRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C1Y9</accession>
    <name>A0A177C1Y9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Bifunctional 6-phosphofructo-2-kinase/fructose-2,6-bisphosphate 2-phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CC84DRAFT_1100452</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441557">
        <property type="protein sequence ID" value="OAG01673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032038.1">
        <property type="nucleotide sequence ID" value="XM_018174867.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C1Y9"/>
    <dbReference type="FunCoup" id="A0A177C1Y9">
        <property type="interactions" value="65"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177C1Y9"/>
    <dbReference type="GeneID" id="28758353"/>
    <dbReference type="InParanoid" id="A0A177C1Y9"/>
    <dbReference type="OrthoDB" id="267323at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003873">
        <property type="term" value="F:6-phosphofructo-2-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006003">
        <property type="term" value="P:fructose 2,6-bisphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006000">
        <property type="term" value="P:fructose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003094">
        <property type="entry name" value="6Pfruct_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013079">
        <property type="entry name" value="6Phosfructo_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001345">
        <property type="entry name" value="PG/BPGM_mutase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10606:SF32">
        <property type="entry name" value="6-PHOSPHOFRUCTO-2-KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10606">
        <property type="entry name" value="6-PHOSPHOFRUCTO-2-KINASE/FRUCTOSE-2,6-BISPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01591">
        <property type="entry name" value="6PF2K"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000709">
        <property type="entry name" value="6PFK_2-Ptase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00991">
        <property type="entry name" value="6PFRUCTKNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00175">
        <property type="entry name" value="PG_MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="6-phosphofructo-2-kinase" evidence="5">
        <location>
            <begin position="123"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="6-phosphofructo-2-kinase" evidence="5">
        <location>
            <begin position="287"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="241"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="20"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="545"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="593"/>
            <end position="594"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR613078-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAG01673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="707" mass="78655" checksum="485B52FDA0CAA9D4" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C1Z4</accession>
    <name>A0A177C1Z4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_277932</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441558">
        <property type="protein sequence ID" value="OAG01181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031546.1">
        <property type="nucleotide sequence ID" value="XM_018185735.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C1Z4"/>
    <dbReference type="GeneID" id="28769221"/>
    <dbReference type="InParanoid" id="A0A177C1Z4"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG01181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="146" mass="15864" checksum="FC2BA7E2D602067C" modified="2016-09-07" version="1">MQQIQATPSVALTPQPKHPMLTHSPSVLVSPHMTSPHPATPPSNTTPHPLHIHPTLFLFTNTSGAKHSKSGRLKTSTHSQGTARTVLVDTWVNGAPRLQRLALQQACDDPGSRADSRSPPRTPISGTSRPARSRRRRDRRRAGDGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C283</accession>
    <name>A0A177C283_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CC84DRAFT_1125805</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="KV441556">
        <property type="protein sequence ID" value="OAG01894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032259.1">
        <property type="nucleotide sequence ID" value="XM_018175729.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C283"/>
    <dbReference type="STRING" id="1460663.A0A177C283"/>
    <dbReference type="ESTHER" id="9pleo-a0a177c283">
        <property type="family name" value="Fungal_carboxylesterase_lipase"/>
    </dbReference>
    <dbReference type="GeneID" id="28759215"/>
    <dbReference type="InParanoid" id="A0A177C283"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003990">
        <property type="term" value="F:acetylcholinesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006581">
        <property type="term" value="P:acetylcholine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019695">
        <property type="term" value="P:choline metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050654">
        <property type="entry name" value="AChE-related_enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918">
        <property type="entry name" value="ACETYLCHOLINESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918:SF4">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007948927" description="Carboxylic ester hydrolase" evidence="3">
        <location>
            <begin position="21"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="34"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="377"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAG01894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="506" mass="55055" checksum="4479108E85442277" modified="2016-09-07" version="1">MWLIQTLIVTCSLLAQSVYGSPVVERHTSHSDNLKVKTNLFSVQGAIFPNEAQVRFFGNIPYAEPPVGNLRFRPPVSAKPRDEIINGTWFGPSCIQYSSGAKTVYSEYLTGFLLSPGQSTSEDCLTLNVWAPLRSKEGDKLPVMIWVHGGGFTSGGAASQYKYGDRIVRDQNVIVVAINYRLNIFGFPKAAALDGHNMNPGLLDQRKAVEWVYENIHAFGGDAGKMTLFGQSAGSMSVDAYTYAYPFDPLVRGFIAQSGTVGTSSYTFDPTGSNFTYVASQLGCNTAASKDKVFSCVQSKPATDIISIYNKYNATLNNGRSLSFGPTADDEVIFSNYTDRQQRGLFAQLPTVYSSNNAEGSSLLAYTPDGPPGGQAAIDAFTKSFGTCSTANGALARKNKGVHVWRIRYFGQWPNLNPFNWLGAYHSADIPMVFGTSDLRGPDTELEKATSKYYQDAWIAFAKDPVNGLVKYGWPKYDPNAETLVKLGNGTAKAVFAKGNLFDAGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C2Y3</accession>
    <name>A0A177C2Y3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Amidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_1190030</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M20A family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441557">
        <property type="protein sequence ID" value="OAG01825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032190.1">
        <property type="nucleotide sequence ID" value="XM_018181092.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C2Y3"/>
    <dbReference type="STRING" id="1460663.A0A177C2Y3"/>
    <dbReference type="GeneID" id="28764578"/>
    <dbReference type="InParanoid" id="A0A177C2Y3"/>
    <dbReference type="OrthoDB" id="4676at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016813">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03884">
        <property type="entry name" value="M20_bAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010158">
        <property type="entry name" value="Amidase_Cbmase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01879">
        <property type="entry name" value="hydantase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32494">
        <property type="entry name" value="ALLANTOATE DEIMINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32494:SF20">
        <property type="entry name" value="PEPTIDASE M20 DIMERISATION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001235">
        <property type="entry name" value="Amidase_carbamoylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="Bacterial exopeptidase dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M20 dimerisation" evidence="3">
        <location>
            <begin position="220"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAG01825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="432" mass="46389" checksum="E5C9DF600727151C" modified="2016-09-07" version="1">MATAHGLKINAQRLNDTLQSTCSSWGALAAPSTGMCRLTLSQEDKGVRDWLVAECKSLGCEVKVDQIGNIFAVRKGEVEGAKPIAMGSHMDTQPAGGRYDGILGVQSALEILRTLHENNIRTYLPIALVNWTNEEGARFPGAMMASGVWSTHSSTPLEACWDLQDKDGISMKHALEDIGYLGTTPADYRENGLECHFELHIEQGPLLEIGGKTVGIVTSVQGMKWFAVRVEGVEGHAGATPMPNRADALVTASRLITVVRDAALSTALGVATVGVIKSDTSSQATIPAGVDFIIDVRCTTDEMVDQLASTIFKSFDKVIADENNGTSYAITRSWGMPQSIFHPRCIEACRNAALKVVGEAQVMEMKSRAGHDTAWTSRVCPSSMIFVPSKDGLSHNPNEYTSPEHCAVGAEVLLEAVLGYDGKVRAGEYMSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C319</accession>
    <name>A0A177C319_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1220810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441557">
        <property type="protein sequence ID" value="OAG01282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031647.1">
        <property type="nucleotide sequence ID" value="XM_018183203.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C319"/>
    <dbReference type="GeneID" id="28766689"/>
    <dbReference type="InParanoid" id="A0A177C319"/>
    <dbReference type="OrthoDB" id="10637665at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="234"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="288"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG01282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="351" mass="38905" checksum="EFE2E925AB18AABF" modified="2016-09-07" version="1">MDVKVKAKEKEELRAKMEVRAKVEPAGPASSTSTFSNSASSTAADVESLFTHQHLLEQAILTCGALPPDPNPLVEAWINLVRDTYLQNMCRRWIAMGIQNKPCLIHGMDMLCMAYSPRLGGEIIKPFKPLTRWLNQWPSSLTYKGDLDERPPLHGKGGILKACGVQYYGGKQPVFDVLHDARAFRKEMRLQERTMTQRKLVMSIVEKKVGAMRATVQRVWKKRYDKESEVVEKYLEHDQSDDGVARTTRPEVEGHDSENHNSESHESEGHNSEGYDSDIYGIEGNDSGNHDSEGHGSEDRRGHGPEAGDSALSPGHVPEVGDSGPSPDSQDEEVTWAEVGGQLFLVTSGTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2023-06-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C3K9</accession>
    <name>A0A177C3K9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1168360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441558">
        <property type="protein sequence ID" value="OAG01250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031615.1">
        <property type="nucleotide sequence ID" value="XM_018179377.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C3K9"/>
    <dbReference type="GeneID" id="28762863"/>
    <dbReference type="InParanoid" id="A0A177C3K9"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG01250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="92" mass="9500" checksum="CC9FF85D5B908AD9" modified="2016-09-07" version="1">MLFRGSAPGDQRAHPNGRCLGSDDSTDLCRCCFGACDSDAGQGLKVAMGSVCVSRRGVSDGEAAIPPARSNTDDRRRGSRSGPSRLAGKTGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C4C5</accession>
    <name>A0A177C4C5_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1100045</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441557">
        <property type="protein sequence ID" value="OAG01577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031942.1">
        <property type="nucleotide sequence ID" value="XM_018174848.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C4C5"/>
    <dbReference type="GeneID" id="28758334"/>
    <dbReference type="InParanoid" id="A0A177C4C5"/>
    <dbReference type="OrthoDB" id="4194555at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="116"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG01577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="965" mass="107172" checksum="A3E477590A2C8987" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C536</accession>
    <name>A0A177C536_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">1,3-beta-glucan synthase</fullName>
            <ecNumber evidence="3">2.4.1.34</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">1,3-beta-D-glucan-UDP glucosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CC84DRAFT_1098277</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>[(1-&gt;3)-beta-D-glucosyl](n) + UDP-alpha-D-glucose = [(1-&gt;3)-beta-D-glucosyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21476"/>
            <dbReference type="Rhea" id="RHEA-COMP:11146"/>
            <dbReference type="Rhea" id="RHEA-COMP:14303"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37671"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.4.1.34"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 48 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.34" evidence="3"/>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG02625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032990.1">
        <property type="nucleotide sequence ID" value="XM_018174759.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A177C536">
        <property type="interactions" value="558"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177C536"/>
    <dbReference type="GeneID" id="28758245"/>
    <dbReference type="InParanoid" id="A0A177C536"/>
    <dbReference type="OrthoDB" id="1880850at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000148">
        <property type="term" value="C:1,3-beta-D-glucan synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003843">
        <property type="term" value="F:1,3-beta-D-glucan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006075">
        <property type="term" value="P:(1-&gt;3)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051278">
        <property type="term" value="P:fungal-type cell wall polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026899">
        <property type="entry name" value="FKS1-like_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056261">
        <property type="entry name" value="FKS1-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003440">
        <property type="entry name" value="Glyco_trans_48_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12741:SF48">
        <property type="entry name" value="1,3-BETA-GLUCAN SYNTHASE COMPONENT FKS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12741">
        <property type="entry name" value="LYST-INTERACTING PROTEIN LIP5 DOPAMINE RESPONSIVE PROTEIN DRG-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14288">
        <property type="entry name" value="FKS1_dom1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23605">
        <property type="entry name" value="FKS1_dom2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02364">
        <property type="entry name" value="Glucan_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01205">
        <property type="entry name" value="FKS1_dom1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="491"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="536"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="578"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="609"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="666"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="720"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1343"/>
            <end position="1362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1395"/>
            <end position="1416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1512"/>
            <end position="1530"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1606"/>
            <end position="1625"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1645"/>
            <end position="1672"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1684"/>
            <end position="1706"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1718"/>
            <end position="1737"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1781"/>
            <end position="1804"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1845"/>
            <end position="1869"/>
        </location>
    </feature>
    <feature type="domain" description="1,3-beta-glucan synthase component FKS1-like" evidence="13">
        <location>
            <begin position="345"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="26"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="60"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="82"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="157"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OAG02625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="1929" mass="220760" checksum="FCE8E8839B4F3B2F" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C566</accession>
    <name>A0A177C566_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_937246</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG02894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033259.1">
        <property type="nucleotide sequence ID" value="XM_018187914.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C566"/>
    <dbReference type="GeneID" id="28771400"/>
    <dbReference type="InParanoid" id="A0A177C566"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="208"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG02894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="227" mass="24402" checksum="74C3753ED0397D21" modified="2016-09-07" version="1">MPAQGPRAPAEPRRLTAACRHSNSDVCQDGQDTRPAPSRPRETCHRPAATSDLSSSEFHARIRPPGRPKPRALIQARGAPETSSPCSVPPDLVPSAHTTSCATGGGLSCRRRCPFDDDRAKRQRSATLPIIPECYIDGLMIMVLLSMDAIPRLCGVLGSSQLVQQRLLCPPRKAAKIGAQSDDTHSHCHQQCVRHTARHESDGRCFINSGPVSGARGPPHHGSSVHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C574</accession>
    <name>A0A177C574_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1219629</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG02665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033030.1">
        <property type="nucleotide sequence ID" value="XM_018183093.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C574"/>
    <dbReference type="GeneID" id="28766579"/>
    <dbReference type="InParanoid" id="A0A177C574"/>
    <dbReference type="OrthoDB" id="3692888at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="346"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="443"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="284"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="16"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="50"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="347"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG02665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="462" mass="50705" checksum="7423F5497F3A3B58" modified="2016-09-07" version="1">MLSTAKVMAPPVSKKTTPKLKKALAKKTAKTISVIPRKRSTQQPTDEDERAPKLQKTDPIDSIASAPKHGSSQTPILLDESDDDTPPAELWSWSRAPFVRVKEEAPPRKSFFSGLGVRGLGNSKSFSRKHAGAGTSAANAAEDVRVELSPNAAGTRPTRSASQNFSLYQKSVMDSERSATRIAELECELEHCKRDREAAIDVLKRDHEATLSRLSQDMGTTVDIMRLEHKSAARLYEVRIESERQNGEANLKSQAETQRLETKSLLDDIQRTATFQDDEKARRITALETEHQGLRDENQSLKGQLSAAKAALEEREVLIPSEDSFKALEARNLALTQELQVIKQHLDTPTGSQSQSQDIRPPTRPEHPLSPTPTLSSSFLASDETKTTNVRNMFLKVKRRHDNLVTVAKRIHDVTTGMDLAAFGEFGRQVGELKKVLHGALKEGAGGGVGGRQVSRGGDGEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C5B2</accession>
    <name>A0A177C5B2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1219872</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG02944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033309.1">
        <property type="nucleotide sequence ID" value="XM_018183118.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C5B2"/>
    <dbReference type="GeneID" id="28766604"/>
    <dbReference type="InParanoid" id="A0A177C5B2"/>
    <dbReference type="OrthoDB" id="3795960at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG02944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="159" mass="17373" checksum="31C5153519531B24" modified="2016-09-07" version="1">MYLGALTTAFVPAPGCIDTIYGEIFSVGTVRDKWHSLGQSDKRSCYPSAFTTPGKYYSPGICPSAWSSAHTSYVFRHKGNANGGMHSGYICASSQTSSSDTFSCSRLYTDPPKITVPQEINGKTTYMETTLAADGGLFVVYANQIEVRFQKGTSRLRHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C5F0</accession>
    <name>A0A177C5F0_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CC84DRAFT_1208110</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <dbReference type="EMBL" id="KV441556">
        <property type="protein sequence ID" value="OAG01947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032312.1">
        <property type="nucleotide sequence ID" value="XM_018182142.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C5F0"/>
    <dbReference type="STRING" id="1460663.A0A177C5F0"/>
    <dbReference type="GeneID" id="28765628"/>
    <dbReference type="InParanoid" id="A0A177C5F0"/>
    <dbReference type="OrthoDB" id="10009520at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd20353">
        <property type="entry name" value="Rcat_RBR_RNF216"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051628">
        <property type="entry name" value="LUBAC_E3_Ligases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047546">
        <property type="entry name" value="Rcat_RBR_RNF216"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047544">
        <property type="entry name" value="RING-HC_RBR_RNF216"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058758">
        <property type="entry name" value="UBA_RNF216"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22770:SF42">
        <property type="entry name" value="FINGER PROTEIN (ZIN), PUTATIVE (AFU_ORTHOLOGUE AFUA_4G03910)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22770">
        <property type="entry name" value="UBIQUITIN CONJUGATING ENZYME 7 INTERACTING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26200">
        <property type="entry name" value="Rcat_RNF216"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26191">
        <property type="entry name" value="RING-HC_RBR_RNF216"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26112">
        <property type="entry name" value="UBA_RNF216"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="8">
        <location>
            <begin position="274"/>
            <end position="584"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAG01947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="660" mass="74756" checksum="BF7F15B5478BB748" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C5J5</accession>
    <name>A0A177C5J5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1252559</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441556">
        <property type="protein sequence ID" value="OAG02159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032524.1">
        <property type="nucleotide sequence ID" value="XM_018184360.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C5J5"/>
    <dbReference type="GeneID" id="28767846"/>
    <dbReference type="InParanoid" id="A0A177C5J5"/>
    <dbReference type="OrthoDB" id="10430758at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="237"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="252"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG02159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="265" mass="28761" checksum="1C28957A2C4F7069" modified="2016-09-07" version="1">MPFTHTHLHLGPRASCHLTCTHDAVPYGSHKRLVTFHPSKSRGLVPTSTPVALHSMPCAANTQPNLHKHHFTHAIIPPSSPSKPSLHTPTLMSSAEPRSKLPTPGKTILNIVTKHQGAAPPTTTMPTLKANPSPTTPILLRHRWRCCHPSCTHLNTSTTPVHFAPYFSPTENAPIRAPGYYGQKCASCAHPACEVCCFLEVSRVDGKSAASAAGERSPWVEIGCWGRREDFPAGEVVGLRSTDELPPASKRGLSEAWRKNGRRDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C672</accession>
    <name>A0A177C672_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cell wall mannoprotein PIR1-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CC84DRAFT_1166794</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PIR protein family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG03025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033390.1">
        <property type="nucleotide sequence ID" value="XM_018179050.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C672"/>
    <dbReference type="STRING" id="1460663.A0A177C672"/>
    <dbReference type="GeneID" id="28762536"/>
    <dbReference type="InParanoid" id="A0A177C672"/>
    <dbReference type="OrthoDB" id="5415592at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005199">
        <property type="term" value="F:structural constituent of cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054508">
        <property type="entry name" value="PIR1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051153">
        <property type="entry name" value="Yeast_CWMannoprotein_PIR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47254">
        <property type="entry name" value="CELL WALL MANNOPROTEIN CIS3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47254:SF1">
        <property type="entry name" value="CELL WALL MANNOPROTEIN CIS3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22799">
        <property type="entry name" value="PIR1-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0134">Cell wall</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 8" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008057804" description="Cell wall mannoprotein PIR1-like C-terminal domain-containing protein" evidence="8">
        <location>
            <begin position="21"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="242"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="Cell wall mannoprotein PIR1-like C-terminal" evidence="9">
        <location>
            <begin position="74"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="211"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="215"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF22799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAG03025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="264" mass="26408" checksum="A0C4B8C65D7FDDCE" modified="2016-09-07" version="1">MRTASILAALSCAATTYAQAVEVGIEPSSPAPEGCDRSPKGNFTIGYIPASAVTKRETAVADADGSLYLTLVDGVLKDGFNRIGSVVANHQFQFDGPPQAGAIYTGGFSICRNDSLAIGGTTRWWNCLSGDFNNLYDESIGAQCTEIRIVATFVDQPSSSSSSAAASSTAGSSSVVTSVTSANGTSSTITSSVASSSTLSAIPLTSINGTKPSGSVSRVSTATPTATSSETGSPQAPNAPGAAAPIAVSTFGALIAVFAAALML</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C6D1</accession>
    <name>A0A177C6D1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">NAD(P)H-hydrate epimerase</fullName>
            <ecNumber evidence="3 10">5.1.99.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">NAD(P)HX epimerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CC84DRAFT_1198458</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>(6R)-NADHX = (6S)-NADHX</text>
            <dbReference type="Rhea" id="RHEA:32215"/>
            <dbReference type="ChEBI" id="CHEBI:64074"/>
            <dbReference type="ChEBI" id="CHEBI:64075"/>
            <dbReference type="EC" id="5.1.99.6"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 10">
            <text>(6R)-NADPHX = (6S)-NADPHX</text>
            <dbReference type="Rhea" id="RHEA:32227"/>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
            <dbReference type="ChEBI" id="CHEBI:64077"/>
            <dbReference type="EC" id="5.1.99.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
        <text evidence="10">Binds 1 potassium ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the NnrE/AIBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="5.1.99.6" evidence="3 10"/>
    <dbReference type="EMBL" id="KV441556">
        <property type="protein sequence ID" value="OAG02250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032615.1">
        <property type="nucleotide sequence ID" value="XM_018181566.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C6D1"/>
    <dbReference type="FunCoup" id="A0A177C6D1">
        <property type="interactions" value="260"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177C6D1"/>
    <dbReference type="GeneID" id="28765052"/>
    <dbReference type="InParanoid" id="A0A177C6D1"/>
    <dbReference type="OrthoDB" id="10064708at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052856">
        <property type="term" value="F:NAD(P)HX epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10260:FF:000005">
        <property type="entry name" value="NAD(P)H-hydrate epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10260">
        <property type="entry name" value="YjeF N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01966">
        <property type="entry name" value="NADHX_epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004443">
        <property type="entry name" value="YjeF_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036652">
        <property type="entry name" value="YjeF_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032976">
        <property type="entry name" value="YJEFN_prot_NAXE-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00197">
        <property type="entry name" value="yjeF_nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13232">
        <property type="entry name" value="NAD(P)H-HYDRATE EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13232:SF10">
        <property type="entry name" value="NAD(P)H-HYDRATE EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03853">
        <property type="entry name" value="YjeF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64153">
        <property type="entry name" value="YjeF N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51385">
        <property type="entry name" value="YJEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8 10" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 10" id="KW-0630">Potassium</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YjeF N-terminal" evidence="11">
        <location>
            <begin position="11"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="61"/>
            <end position="65"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="127"/>
            <end position="133"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OAG02250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="236" mass="25631" checksum="6D4940C789DD0DBD" modified="2016-09-07" version="1">MALRTLSAKSAAALDQELMSTGAFSIDQLMELAGLSVSQAVFKLQPLSKGKRILVACGPGNNGGDGLVAARHLFHYGYQPTIYYPKQSKNDLYQRLKKQLQDLKVPFTDDFPSALKSADHIVDAIFGFSFSGEVREPFPSVIEALRDTKIPVLAVDAPSSWNIEDGPPSEGPGKGFMPEALISLTAPKPLVKWFKGRHFLGGRFLGPEVAEKYGLDVPKYEGLDQVVEVPVEGGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C6M7</accession>
    <name>A0A177C6M7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Small ribosomal subunit protein bS6m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_1166823</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial ribosomal protein bS6 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG03056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033421.1">
        <property type="nucleotide sequence ID" value="XM_018179059.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C6M7"/>
    <dbReference type="FunCoup" id="A0A177C6M7">
        <property type="interactions" value="215"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177C6M7"/>
    <dbReference type="GeneID" id="28762545"/>
    <dbReference type="InParanoid" id="A0A177C6M7"/>
    <dbReference type="OrthoDB" id="10259681at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070181">
        <property type="term" value="F:small ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15465">
        <property type="entry name" value="bS6_mito"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.60:FF:000007">
        <property type="entry name" value="37S ribosomal protein Mrp17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000529">
        <property type="entry name" value="Ribosomal_bS6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035980">
        <property type="entry name" value="Ribosomal_bS6_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014717">
        <property type="entry name" value="Transl_elong_EF1B/ribsomal_bS6"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00166">
        <property type="entry name" value="S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21011">
        <property type="entry name" value="MITOCHONDRIAL 28S RIBOSOMAL PROTEIN S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21011:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN BS6M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01250">
        <property type="entry name" value="Ribosomal_S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54995">
        <property type="entry name" value="Ribosomal protein S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 8" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAG03056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="112" mass="12708" checksum="A9AB8B8AF0F5BFEB" modified="2016-09-07" version="1">MLYEMIGVVRPGRLSEVKEIAKTAGKIVLERNGVVRGVTNWGTFLLPKPAKKLQSSHNVGHHFIMRFDASARTQHSLRRTMSLDPRLIRYSIVKMGTKFEEIKDIAGQASFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C8B6</accession>
    <name>A0A177C8B6_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Copper transport protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_1188283</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG03646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034011.1">
        <property type="nucleotide sequence ID" value="XM_018180980.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C8B6"/>
    <dbReference type="FunCoup" id="A0A177C8B6">
        <property type="interactions" value="26"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177C8B6"/>
    <dbReference type="GeneID" id="28764466"/>
    <dbReference type="InParanoid" id="A0A177C8B6"/>
    <dbReference type="OrthoDB" id="161814at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005375">
        <property type="term" value="F:copper ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007274">
        <property type="entry name" value="Cop_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12483:SF73">
        <property type="entry name" value="COPPER TRANSPORT PROTEIN CTR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12483">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 31 COPPER TRANSPORTERS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04145">
        <property type="entry name" value="Ctr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0186">Copper</keyword>
    <keyword evidence="6" id="KW-0187">Copper transport</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="146"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="172"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="109"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="109"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAG03646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="212" mass="23003" checksum="E596D3C43F63D6D4" modified="2016-09-07" version="1">MSMSGMDMGTATSTGVMPSGTASMDMGGMGGMDMGGGGGSACKISMLWNWYTVDTCFLSETWHNTSKGMFAGSCIGVICLVLILEFLRRAGKEYDRYILAQHTRSLAEASPVPDSSSSDAVNKNPASSTTRTVPPRSFRPTILQQAIRALLHMLQFAVAYFVMLLAMYYNGYIIICIFIGAFLGFFVFGWESFNVSQGGKDRMQEEVTVCCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2024-01-24" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C8E8</accession>
    <name>A0A177C8E8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_959696</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG03129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033494.1">
        <property type="nucleotide sequence ID" value="XM_018187955.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C8E8"/>
    <dbReference type="GeneID" id="28771441"/>
    <dbReference type="InParanoid" id="A0A177C8E8"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG03129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="189" mass="21116" checksum="7989123E13D3A93E" modified="2016-09-07" version="1">MPRIRIDCRTLLPRPERVILLGNVEAAEDEERLYLQSRKFVEILLNVQPKAQWQTAQCRYKRFGDAFAIEKAVVEVMGRFDADAKTAQVFQLRRFADCVIPCLEVANHIARCGEGAGVSSVCAGDFWSGAPHAREEGGWDAGSLSPGQRGGLGRKIRRAVVLQVAVVVRPWSSKQLHQLPHYAWTVHIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C9Q4</accession>
    <name>A0A177C9Q4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Iron-sulfur clusters transporter ATM1, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Iron-sulfur clusters transporter atm1, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CC84DRAFT_1218806</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the ABC transporter superfamily. ABCB family. Heavy Metal importer (TC 3.A.1.210) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG03487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033852.1">
        <property type="nucleotide sequence ID" value="XM_018183033.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C9Q4"/>
    <dbReference type="FunCoup" id="A0A177C9Q4">
        <property type="interactions" value="664"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177C9Q4"/>
    <dbReference type="GeneID" id="28766519"/>
    <dbReference type="InParanoid" id="A0A177C9Q4"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140466">
        <property type="term" value="P:iron-sulfur cluster export from the mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18582">
        <property type="entry name" value="ABC_6TM_ATM1_ABCB7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03253">
        <property type="entry name" value="ABCC_ATM1_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000004">
        <property type="entry name" value="ATP-binding cassette sub-family B member 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000186">
        <property type="entry name" value="ATP-binding cassette sub-family B member 7, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221:SF402">
        <property type="entry name" value="IRON-SULFUR CLUSTERS TRANSPORTER ABCB7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="17" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="112"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="145"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="226"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="259"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="16">
        <location>
            <begin position="114"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="15">
        <location>
            <begin position="436"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="37"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00039906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00040792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="OAG03487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="695" mass="76524" checksum="E9412A3E75130E01" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CA84</accession>
    <name>A0A177CA84_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Lecithin:cholesterol acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1165926</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG03739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034104.1">
        <property type="nucleotide sequence ID" value="XM_018178831.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CA84"/>
    <dbReference type="FunCoup" id="A0A177CA84">
        <property type="interactions" value="237"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CA84"/>
    <dbReference type="GeneID" id="28762317"/>
    <dbReference type="InParanoid" id="A0A177CA84"/>
    <dbReference type="OrthoDB" id="190846at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032541">
        <property type="term" value="C:cortical endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005637">
        <property type="term" value="C:nuclear inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097038">
        <property type="term" value="C:perinuclear endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008374">
        <property type="term" value="F:O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046027">
        <property type="term" value="F:phospholipid:diacylglycerol acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006672">
        <property type="term" value="P:ceramide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140042">
        <property type="term" value="P:lipid droplet formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055091">
        <property type="term" value="P:phospholipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019432">
        <property type="term" value="P:triglyceride biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003386">
        <property type="entry name" value="LACT/PDAT_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11440">
        <property type="entry name" value="LECITHIN-CHOLESTEROL ACYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02450">
        <property type="entry name" value="LCAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG03739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="498" mass="56113" checksum="FF82C24BDA128EA3" modified="2016-09-07" version="1">MIPGVISTGLESWSTEDDSRQYFRKRLWGSWSMMRALVVDKPSWKKHIMLDTKTGLDPPGIKLRAAQGFDATDFFITGYWIWNKILENLATIGYDPTNAFTAAYDWRMSYMNYERRDQYFTRLKSHIEIAVRVQNKKAVLLSHSMGSQVLYYFLHWVEAEGYGNGGPGWVEAYIDSWINISGCMLGALKGMPAVLSGEMKDTAQLNAFAVYGLEKFLSRHERAEIFRAMPGISSMLPLGGNAVWGDHTGAPDDQPGQNISYGNFLRFARESNSSLTKTNLTVEESFPYLYKNSEQWYKEMVMKSYSHGVAHTAHEVEDNQLIPAKWINPLETRLPLAPSLKIYCFYGIGKPTERAFYYRDDLDPLSKLNVTLDTMFSGNGGVDHGVVLGEGDGTVNLLSSGYMCAKGWGMKRYNPAGVKIKTVEMPHEPDQFSPRGGPNTGDHVDILGRSSLNDLILRVAGGQGEQIEETIHSNIREYADKVKIYEEGEEGERRRVPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CA96</accession>
    <name>A0A177CA96_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">KOW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CC84DRAFT_1218978</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL27 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG03687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034052.1">
        <property type="nucleotide sequence ID" value="XM_018183047.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CA96"/>
    <dbReference type="FunCoup" id="A0A177CA96">
        <property type="interactions" value="1024"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CA96"/>
    <dbReference type="GeneID" id="28766533"/>
    <dbReference type="InParanoid" id="A0A177CA96"/>
    <dbReference type="OrthoDB" id="2365484at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06090">
        <property type="entry name" value="KOW_RPL27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.770:FF:000001">
        <property type="entry name" value="60S ribosomal protein L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001141">
        <property type="entry name" value="Ribosomal_eL27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041991">
        <property type="entry name" value="Ribosomal_eL27_KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038655">
        <property type="entry name" value="Ribosomal_eL27_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10497">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00467">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01777">
        <property type="entry name" value="Ribosomal_L27e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00739">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="KOW" evidence="4">
        <location>
            <begin position="3"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAG03687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="135" mass="15679" checksum="8488C6DC958F33E9" modified="2016-09-07" version="1">MKFLKVGRVVIITRGRYAGKKCVIISPLDNGTKSHPFPHALVAGIERYPSKVTRRMSKKKQDKKSKVKPFVKQVNYTHIMPTRYTLELENLKGVVSADTFKEVSQREEAKKTVKKAFEERYTSGKNRWFFTPLQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CAD9</accession>
    <name>A0A177CAD9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Beta-glucosidase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_866541</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG03789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034154.1">
        <property type="nucleotide sequence ID" value="XM_018187711.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CAD9"/>
    <dbReference type="STRING" id="1460663.A0A177CAD9"/>
    <dbReference type="GeneID" id="28771197"/>
    <dbReference type="InParanoid" id="A0A177CAD9"/>
    <dbReference type="OrthoDB" id="65569at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001360">
        <property type="entry name" value="Glyco_hydro_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10353:SF53">
        <property type="entry name" value="BETA-1,4-GLUCOSIDASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10353">
        <property type="entry name" value="GLYCOSYL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00232">
        <property type="entry name" value="Glyco_hydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012227105" evidence="2">
        <location>
            <begin position="16"/>
            <end position="627"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG03789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="627" mass="70044" checksum="FC5D623A1A02F1B9" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CB03</accession>
    <name>A0A177CB03_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mid2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_1261047</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG04029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034394.1">
        <property type="nucleotide sequence ID" value="XM_018185030.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CB03"/>
    <dbReference type="STRING" id="1460663.A0A177CB03"/>
    <dbReference type="GeneID" id="28768516"/>
    <dbReference type="InParanoid" id="A0A177CB03"/>
    <dbReference type="OrthoDB" id="3557178at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12087">
        <property type="entry name" value="TM_EGFR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008057960" description="Mid2 domain-containing protein" evidence="3">
        <location>
            <begin position="19"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="217"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="247"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="302"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="169"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="249"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="268"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="352"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAG04029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="380" mass="40136" checksum="75FF317BE407E5E0" modified="2016-09-07" version="1">MLGRIFASYALFACYSLAELLTATREASDPTITTAPNIPIELLRKQAVGDRFIGWISIDGEWTSRSCDVGGTYFQSDEIWKCCATTLDGCNAPVGCAAGSLIYSIYTSSSYSYTTIACTEAYDDPDATSWSVCNTGLMYENTADFDPVTNIFCGASASRFTYYRVRPSESTSSSSEFSTPASTSAHPTDTSLGPADSATSTPSPTPLPQPTKPKSKAWIAGAVVGPIIGLALIGLLAWFLLVRRKKKTTPPPPPPPPPPMQQQQYNGPPSPYPGSPAQPPKSYYNAQKPPAAAVVPMGVASHQSWAAPPPHSPTSQGAVSPHVPPQNLYGQQAYPGPGQSPSPPNVHAYAVGGEGKPLGVGGYGERPFSAELDGGQQRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CB47</accession>
    <name>A0A177CB47_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Kinesin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CC84DRAFT_1196691</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. KIN-14 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG04546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034911.1">
        <property type="nucleotide sequence ID" value="XM_018181482.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CB47"/>
    <dbReference type="STRING" id="1460663.A0A177CB47"/>
    <dbReference type="GeneID" id="28764968"/>
    <dbReference type="InParanoid" id="A0A177CB47"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000235">
        <property type="term" value="C:astral microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055028">
        <property type="term" value="C:cortical microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090619">
        <property type="term" value="C:meiotic spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036449">
        <property type="term" value="C:microtubule minus-end"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035371">
        <property type="term" value="C:microtubule plus-end"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005872">
        <property type="term" value="C:minus-end kinesin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990537">
        <property type="term" value="C:mitotic spindle polar microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008569">
        <property type="term" value="F:minus-end-directed microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030951">
        <property type="term" value="P:establishment or maintenance of microtubule cytoskeleton polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000742">
        <property type="term" value="P:karyogamy involved in conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990571">
        <property type="term" value="P:meiotic centromere clustering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140642">
        <property type="term" value="P:meiotic spindle formation (spindle phase two)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990810">
        <property type="term" value="P:microtubule anchoring at mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001578">
        <property type="term" value="P:microtubule bundle formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031534">
        <property type="term" value="P:minus-end directed microtubule sliding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990942">
        <property type="term" value="P:mitotic metaphase chromosome recapture"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140641">
        <property type="term" value="P:mitotic spindle formation (spindle phase two)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051256">
        <property type="term" value="P:mitotic spindle midzone assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090561">
        <property type="term" value="P:nuclear migration during mitotic telophase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000743">
        <property type="term" value="P:nuclear migration involved in conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031535">
        <property type="term" value="P:plus-end directed microtubule sliding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01366">
        <property type="entry name" value="KISc_C_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000065">
        <property type="entry name" value="Kinesin-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47972">
        <property type="entry name" value="KINESIN-LIKE PROTEIN KLP-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47972:SF45">
        <property type="entry name" value="PROTEIN CLARET SEGREGATIONAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4 11" id="KW-0493">Microtubule</keyword>
    <keyword evidence="8 10 11" id="KW-0505">Motor protein</keyword>
    <keyword evidence="5 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="14">
        <location>
            <begin position="481"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="229"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="290"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="12"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="74"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="97"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="136"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="159"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="572"/>
            <end position="579"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OAG04546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="827" mass="92740" checksum="724A04EFF1FBF88F" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CBD3</accession>
    <name>A0A177CBD3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CC84DRAFT_1165267</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SDE2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG04905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035270.1">
        <property type="nucleotide sequence ID" value="XM_018178679.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CBD3"/>
    <dbReference type="STRING" id="1460663.A0A177CBD3"/>
    <dbReference type="GeneID" id="28762165"/>
    <dbReference type="InParanoid" id="A0A177CBD3"/>
    <dbReference type="OrthoDB" id="547031at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051421">
        <property type="entry name" value="RNA_Proc_DNA_Dmg_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053822">
        <property type="entry name" value="SDE2-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024974">
        <property type="entry name" value="Sde2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12786">
        <property type="entry name" value="SPLICING FACTOR SF3A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12786:SF1">
        <property type="entry name" value="SPLICING REGULATOR SDE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22782">
        <property type="entry name" value="SDE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13019">
        <property type="entry name" value="Sde2_N_Ubi_yeast"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sde2 ubiquitin" evidence="10">
        <location>
            <begin position="24"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="SDE2-like" evidence="11">
        <location>
            <begin position="103"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="113"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="201"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="206"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="226"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="250"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="266"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF22782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OAG04905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="284" mass="31465" checksum="4E06148F512EA7D7" modified="2016-09-07" version="1">MAQAATVSGHHCVPTLNANGNAPVTVLVNTVRGTIAFTVVKAAPLSSIYETLYDRAPWIANTSYILTTHSRRTVPTTDGPVSSLLSSASDTFISLRLSVPLCGGKGGFGSILRAQGGRMSSRKKKQGEVNGSSRNLDGRRLRTVAEAKTLAEYLAIKPEMDKREKEERRKRWEDIVASTERKQDELMSGRTQGRLNGKWVEDKEEAENKTREAIEKMLMAQQQSSSEEEEEEEQVAESSKPAAQRTMFGWDDEDDEFMSDSEEEEKMLGEDKPKYEGKGKGKAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CBL0</accession>
    <name>A0A177CBL0_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ribonuclease T1</fullName>
            <ecNumber evidence="2">4.6.1.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CC84DRAFT_1218022</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>[RNA] containing guanosine + H2O = an [RNA fragment]-3'-guanosine-3'-phosphate + a 5'-hydroxy-ribonucleotide-3'-[RNA fragment].</text>
            <dbReference type="EC" id="4.6.1.24"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ribonuclease N1/T1 family.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.24" evidence="2"/>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG04581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034946.1">
        <property type="nucleotide sequence ID" value="XM_018182953.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CBL0"/>
    <dbReference type="GeneID" id="28766439"/>
    <dbReference type="InParanoid" id="A0A177CBL0"/>
    <dbReference type="OrthoDB" id="5425539at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046589">
        <property type="term" value="F:ribonuclease T1 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00606">
        <property type="entry name" value="fungal_RNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.30">
        <property type="entry name" value="Microbial ribonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000026">
        <property type="entry name" value="N1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016191">
        <property type="entry name" value="Ribonuclease/ribotoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048269">
        <property type="entry name" value="RNase_U2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42104">
        <property type="entry name" value="EXTRACELLULAR GUANYL-SPECIFIC RIBONUCLEASE RNTA (AFU_ORTHOLOGUE AFUA_4G03230)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42104:SF1">
        <property type="entry name" value="EXTRACELLULAR GUANYL-SPECIFIC RIBONUCLEASE RNTA (AFU_ORTHOLOGUE AFUA_4G03230)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00545">
        <property type="entry name" value="Ribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037430">
        <property type="entry name" value="RNase_U2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53933">
        <property type="entry name" value="Microbial ribonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008057971" description="ribonuclease T1" evidence="10">
        <location>
            <begin position="20"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OAG04581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="130" mass="13223" checksum="B3392A1501E2E879" modified="2016-09-07" version="1">MFGSINLVSILLLVSSAAALPAELDKRAAAKCGSVSYTAAAVNAASQKACSYYQAGTQVGSNSYPHTFNNNEGFSFAVSGPYLEFPILSSGALYTGGSPGADRVVINTSCKQAGAITHTGASGNNFVKCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CCP0</accession>
    <name>A0A177CCP0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1218009</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG04569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034934.1">
        <property type="nucleotide sequence ID" value="XM_018182952.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CCP0"/>
    <dbReference type="STRING" id="1460663.A0A177CCP0"/>
    <dbReference type="GeneID" id="28766438"/>
    <dbReference type="InParanoid" id="A0A177CCP0"/>
    <dbReference type="OrthoDB" id="167809at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG04569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="219" mass="24603" checksum="6A002095E4A9754E" modified="2016-09-07" version="1">MPNVLVLSFEGFSFSSRQLYEQLLPKLLSRAAIHESLTIQDAMNYILSGWPNVILVTDPVIAEESEESQRLLEAVADYTKHHSCTTILMGFFVAAIETETLDYIFKHHFNLKWKALPEEPSTHEARIHASDQSLLRTTTLVPKLVANAAWLTGVAPPQATYFGPIERGIAYAAFTRVGLGKLGYIGDTGFGDEPERLVLAMCHLDRPEDRIMHDEDFEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CD79</accession>
    <name>A0A177CD79_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1093895</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG04822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035187.1">
        <property type="nucleotide sequence ID" value="XM_018174543.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CD79"/>
    <dbReference type="STRING" id="1460663.A0A177CD79"/>
    <dbReference type="GeneID" id="28758029"/>
    <dbReference type="InParanoid" id="A0A177CD79"/>
    <dbReference type="OrthoDB" id="2522477at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG04822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="476" mass="53595" checksum="1AA9D7591377FB0F" modified="2016-09-07" version="1" fragment="single">MAATAHIDRTNPHSLFYLPDELLVQLVSHLAGDAQTLCSLARVSRFFQIEAEKHIYTKIELLSTNDLHAIIEAFTRRFDRVASVETLKILYRFHGGLGATADERAVFNACVGGMKALRSWEIESPYDNYKWDEGGDEWVLKDMEKFRAHLETASLKAAAGSLTGPGDVGLAKLQRLVIHTHGVSDDFWNLGEFHCLFRHPSLRYLHVSCLALPPDLPKLEPYARTTPLTDLVFDECELEPRSLGRILATPKKLKHLTLGENVYNINEGRGANPRLTRAPEAALAALSHVAHSLETLVHYDPAWRINMNYHKALPIPGGGMRDFHSLKTLRVDTCSFLHRSIALSHTQAPPNLHTLQIRNPRPRVTRFGPLAASTNDDFFEHLPPHDPYTYLASLKTLDFVQGATSEMPMAKTLHITEDEALRERHKTGYKLFKHGINLKVTLEATWRAALIPPFLHGEPLPELICVYDAQEIGFNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CE26</accession>
    <name>A0A177CE26_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ribosomal RNA-processing protein 43</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CC84DRAFT_811063</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase PH family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG04980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035345.1">
        <property type="nucleotide sequence ID" value="XM_018187520.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CE26"/>
    <dbReference type="STRING" id="1460663.A0A177CE26"/>
    <dbReference type="GeneID" id="28771006"/>
    <dbReference type="InParanoid" id="A0A177CE26"/>
    <dbReference type="OrthoDB" id="45882at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035925">
        <property type="term" value="F:mRNA 3'-UTR AU-rich region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000467">
        <property type="term" value="P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071028">
        <property type="term" value="P:nuclear mRNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034473">
        <property type="term" value="P:U1 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034476">
        <property type="term" value="P:U5 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="entry name" value="GHMP Kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050590">
        <property type="entry name" value="Exosome_comp_Rrp42_subfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11097:SF9">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11097">
        <property type="entry name" value="EXOSOME COMPLEX EXONUCLEASE RIBOSOMAL RNA PROCESSING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="Ribonuclease PH domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0271">Exosome</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="10">
        <location>
            <begin position="57"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OAG04980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="362" mass="39383" checksum="E733D668F9E8017D" modified="2016-09-07" version="1">MAATTAAAHQQPVHGPALTFPRPIFAAVAPHPFLQAHLSASQPSKAPLRANSRTAHEFRRVGINTGSLTHCNGSAVVRLGNTSAVCGVRAEILHEEHVQGTADFAPSTGNEAEEDLEREREREEIESLRVLVPNVELSTGSTPQHIPGNAPSSFAQTLITRVRSLLLSTSLVRLSDLRILYTPPSNPDDPDAEPEPQLKGYWVLYIDIFYISIDGNAFDAAWIAILAALKNSVIPHAFWDEDLETILCSDDPSEAHPLTLRGLPVPSTFAVFEGKRDWNESGEDEEADWVLSDPDAFEESVCRESVCVVVDCTGGNKGTKDGILKRLEKSGGGVVDRDVMKGLVKRAVDRWQEVETATNAKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CED5</accession>
    <name>A0A177CED5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1260348</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG05100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035465.1">
        <property type="nucleotide sequence ID" value="XM_018184983.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CED5"/>
    <dbReference type="GeneID" id="28768469"/>
    <dbReference type="InParanoid" id="A0A177CED5"/>
    <dbReference type="OrthoDB" id="3799483at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="616"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="788"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="617"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="632"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="801"/>
            <end position="813"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG05100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="883" mass="100744" checksum="18E84C05229F088C" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CFI6</accession>
    <name>A0A177CFI6_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">prephenate dehydratase</fullName>
            <ecNumber evidence="2">4.2.1.51</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CC84DRAFT_1164181</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>prephenate + H(+) = 3-phenylpyruvate + CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:21648"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:18005"/>
            <dbReference type="ChEBI" id="CHEBI:29934"/>
            <dbReference type="EC" id="4.2.1.51"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-phenylalanine biosynthesis; phenylpyruvate from prephenate: step 1/1.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.51" evidence="2"/>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG05712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036077.1">
        <property type="nucleotide sequence ID" value="XM_018178436.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CFI6"/>
    <dbReference type="FunCoup" id="A0A177CFI6">
        <property type="interactions" value="117"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CFI6"/>
    <dbReference type="GeneID" id="28761922"/>
    <dbReference type="InParanoid" id="A0A177CFI6"/>
    <dbReference type="OrthoDB" id="983542at2759"/>
    <dbReference type="UniPathway" id="UPA00121">
        <property type="reaction ID" value="UER00345"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004664">
        <property type="term" value="F:prephenate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009094">
        <property type="term" value="P:L-phenylalanine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04905">
        <property type="entry name" value="ACT_CM-PDT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13532">
        <property type="entry name" value="PBP2_PDT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.10:FF:000034">
        <property type="entry name" value="Chorismate mutase/prephenate dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008242">
        <property type="entry name" value="Chor_mutase/pphenate_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001086">
        <property type="entry name" value="Preph_deHydtase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21022">
        <property type="entry name" value="PREPHENATE DEHYDRATASE P PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21022:SF19">
        <property type="entry name" value="PREPHENATE DEHYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00800">
        <property type="entry name" value="PDT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001500">
        <property type="entry name" value="Chor_mut_pdt_Ppr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="ACT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51171">
        <property type="entry name" value="PREPHENATE_DEHYDR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-0584">Phenylalanine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prephenate dehydratase" evidence="9">
        <location>
            <begin position="14"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="ACT" evidence="10">
        <location>
            <begin position="271"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="114"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="139"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OAG05712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="358" mass="38372" checksum="5C8707EF6B96E1A1" modified="2016-09-07" version="1">MSEESGEKGAQKPVVTFLGPVASYTHQATLSAFPNSTHTLTPTTTIEDVFASVQSGAAARGVVPFENSSNGSVVFTLDLFADVQAKYPDIVVCAESYVPVQHCLLGHARSDQQHATSLSSPGNAGGAGRRAGTGVIPSPLSSGAVTPTPSIPNPTKPTARPLSDLSRITKLYSHPQAWGQCKVFLNTYLKGVERQDVSSTSRAAQIVAEDESGESAAVSSAFAAEVCGLGVLARGIEDRVDNTTRFLVIKRRGDGRADGKDGADGEWKTLVSFTVDHANPGSLAHSLAVFEKYELNLTSINTRPSGVENWNYIFFVELKGRREEGTLDGPVNEALRELDPVCRSWRWLGSWESRLPQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CFI7</accession>
    <name>A0A177CFI7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 9">Imidazoleglycerol-phosphate dehydratase</fullName>
            <ecNumber evidence="4 9">4.2.1.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CC84DRAFT_1164007</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + H2O</text>
            <dbReference type="Rhea" id="RHEA:11040"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57766"/>
            <dbReference type="ChEBI" id="CHEBI:58278"/>
            <dbReference type="EC" id="4.2.1.19"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 6/9.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the imidazoleglycerol-phosphate dehydratase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.19" evidence="4 9"/>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG05480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035845.1">
        <property type="nucleotide sequence ID" value="XM_018178391.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CFI7"/>
    <dbReference type="FunCoup" id="A0A177CFI7">
        <property type="interactions" value="218"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CFI7"/>
    <dbReference type="GeneID" id="28761877"/>
    <dbReference type="InParanoid" id="A0A177CFI7"/>
    <dbReference type="OrthoDB" id="447729at2759"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00011"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004424">
        <property type="term" value="F:imidazoleglycerol-phosphate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:L-histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07914">
        <property type="entry name" value="IGPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.40:FF:000005">
        <property type="entry name" value="Imidazoleglycerol-phosphate dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.40:FF:000001">
        <property type="entry name" value="Imidazoleglycerol-phosphate dehydratase HisB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.40">
        <property type="entry name" value="Imidazole glycerol phosphate dehydratase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00076">
        <property type="entry name" value="HisB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038494">
        <property type="entry name" value="IGPD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000807">
        <property type="entry name" value="ImidazoleglycerolP_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020565">
        <property type="entry name" value="ImidazoleglycerP_deHydtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23133:SF2">
        <property type="entry name" value="IMIDAZOLEGLYCEROL-PHOSPHATE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23133">
        <property type="entry name" value="IMIDAZOLEGLYCEROL-PHOSPHATE DEHYDRATASE HIS7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00475">
        <property type="entry name" value="IGPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00954">
        <property type="entry name" value="IGP_DEHYDRATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00955">
        <property type="entry name" value="IGP_DEHYDRATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7 9" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="8 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAG05480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="229" mass="24973" checksum="6107439387C6CE43" modified="2016-09-07" version="1">MPRTATINRDTNETKIQCTINLDGGELLPFESTPFWDAIDKAAQNGDKDHASQTSTSQAISVDTGIGFLDHMLHALSKHAGWSLRLRCRGDLHIDDHHTAEDTCLALGTAFKDALKGSTGLARFGYAYAPLDEALSRAVIDLSNRPFCVAELGLRREKIGDLSTEMIPHCLQSFAQASGTTLHVDCLRGDNDHHRAESAFKALAVAIRQATTVVKAWEGEVRSTKGVLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CFI8</accession>
    <name>A0A177CFI8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">GroES-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CC84DRAFT_1176165</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG06106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036471.1">
        <property type="nucleotide sequence ID" value="XM_018180200.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CFI8"/>
    <dbReference type="STRING" id="1460663.A0A177CFI8"/>
    <dbReference type="GeneID" id="28763686"/>
    <dbReference type="InParanoid" id="A0A177CFI8"/>
    <dbReference type="OrthoDB" id="10257049at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08249">
        <property type="entry name" value="enoyl_reductase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047122">
        <property type="entry name" value="Trans-enoyl_RdTase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348">
        <property type="entry name" value="HYPOTHETICAL OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348:SF2">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE PROTEIN C2E1P3.01"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="4">
        <location>
            <begin position="10"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAG06106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="334" mass="35807" checksum="79CB760FB3FD362A" modified="2016-09-07" version="1">MNTQRKNLAAILPAPQAEFVVEERPIPTPGPDEVLVRNHFIGLNPLDWKRQLTGMFVPSYPAILGTDLSGIVEAVGSNVSNVKPGDRVLGGADGMISHKLDNASYQTYTTLRASSTSKLPMNVTSYLLLFHLLGLPKPESNAQPPNATLLIWGGASIVGNLTIQLAKLAGLNVYATASEKHHEYLRSLGANLLFDYHSDTVIEDAVAAAESEGKPIAYVADTIASSATLSSVQDVLSNSTAIAKVIAHTAPWPEELTKLDGIKTDMVHGEEVWYKPDMIQLGSTIFHEHLPKWLETGAIVPPPYRVIEGGVGKIQAGLKVLKAGVSNQKVVVAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CFJ3</accession>
    <name>A0A177CFJ3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1164658</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG06383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036748.1">
        <property type="nucleotide sequence ID" value="XM_018178533.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CFJ3"/>
    <dbReference type="FunCoup" id="A0A177CFJ3">
        <property type="interactions" value="346"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CFJ3"/>
    <dbReference type="GeneID" id="28762019"/>
    <dbReference type="InParanoid" id="A0A177CFJ3"/>
    <dbReference type="OrthoDB" id="446809at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055080">
        <property type="entry name" value="Gal80p-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051317">
        <property type="entry name" value="Gfo/Idh/MocA_oxidoreduct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43708">
        <property type="entry name" value="CONSERVED EXPRESSED OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43708:SF1">
        <property type="entry name" value="GALACTOSE_LACTOSE METABOLISM REGULATORY PROTEIN GAL80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22685">
        <property type="entry name" value="Gal80p_C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="1">
        <location>
            <begin position="9"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="Gal80p-like C-terminal" evidence="2">
        <location>
            <begin position="161"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG06383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="387" mass="41801" checksum="27C94227CD9FAA2C" modified="2016-09-07" version="1">MASAPTPLRTALIGLSSSATTSWASAAHLPGLLSPTGRSKLPITALLNSSVSAAQSAIQVYKLAPDTKAYGSPEDLANDPDVDLVICNTRVDTHFATILPSVRKGKDVFVEWPIAAGPKEVETLVREARESGSRVAVGLQRRWAPPAVKLREVIRDGLGGKTLGKILSVDVRAFGGTIDRDVVPEGLAYFLDRKVGGNVVVIGNGHLLDTVLSVVGDLESSSVHSQLQLQRPNVRVRDPSTNKIIKTIRSDVPDLISLHGTLQSSSATFSYLFRRGQPFPGTPALTWTINLEYGEIRLVSPSGLSLELGEPATIHVHWFDSNEVEEVKWEWDAEQATLPPSARNVISTLVAFADRKAPGDGWVSLEDAANRARLIEGFLAEWEKSQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CH64</accession>
    <name>A0A177CH64_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Copper transport protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CC84DRAFT_754388</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG06198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036563.1">
        <property type="nucleotide sequence ID" value="XM_018187310.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CH64"/>
    <dbReference type="STRING" id="1460663.A0A177CH64"/>
    <dbReference type="GeneID" id="28770796"/>
    <dbReference type="InParanoid" id="A0A177CH64"/>
    <dbReference type="OrthoDB" id="73901at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005375">
        <property type="term" value="F:copper ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007274">
        <property type="entry name" value="Cop_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12483:SF120">
        <property type="entry name" value="HIGH-AFFINITY COPPER TRANSPORTER CTRA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12483">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 31 COPPER TRANSPORTERS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04145">
        <property type="entry name" value="Ctr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="4" id="KW-0187">Copper transport</keyword>
    <keyword evidence="4" id="KW-0406">Ion transport</keyword>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="149"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAG06198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="186" mass="20061" checksum="A7795C646F46E4F0" modified="2016-09-07" version="1">MESMSMATVTSTMAGMSMSMPMATESATSGSMDMGSSSVMAMSTMAMTTWTPASAGQYAGTCIFLIAFAAIFRALIAIRFNFDRFSAKIASTRGDNQAHLYTDEYKGAHRPWRANEAVALGAMDVVIAGVSYLLYVSSRVRVLPSLTDFRMIAVMTMNVGYFLSVLAGVFIGSMAFGRFMSRSITQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CH84</accession>
    <name>A0A177CH84_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CC84DRAFT_1091664</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG06218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036583.1">
        <property type="nucleotide sequence ID" value="XM_018174408.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CH84"/>
    <dbReference type="STRING" id="1460663.A0A177CH84"/>
    <dbReference type="GeneID" id="28757894"/>
    <dbReference type="InParanoid" id="A0A177CH84"/>
    <dbReference type="OrthoDB" id="4898680at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF40">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="7"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="13"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="54"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="17"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAG06218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="665" mass="74336" checksum="03339387D6D96317" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CHV9</accession>
    <name>A0A177CHV9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Beta-lactamase/transpeptidase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_1174523</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-A beta-lactamase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG06562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036927.1">
        <property type="nucleotide sequence ID" value="XM_018180101.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CHV9"/>
    <dbReference type="STRING" id="1460663.A0A177CHV9"/>
    <dbReference type="GeneID" id="28763587"/>
    <dbReference type="InParanoid" id="A0A177CHV9"/>
    <dbReference type="OrthoDB" id="428260at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="entry name" value="DD-peptidase/beta-lactamase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050789">
        <property type="entry name" value="Diverse_Enzym_Activities"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43283:SF17">
        <property type="entry name" value="(LOVD), PUTATIVE (AFU_ORTHOLOGUE AFUA_5G00920)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43283">
        <property type="entry name" value="BETA-LACTAMASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="beta-lactamase/transpeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase-related" evidence="3">
        <location>
            <begin position="21"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAG06562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="451" mass="48677" checksum="F0BF2E6BB34EB6AA" modified="2016-09-07" version="1">MATEFETKLNELQEAGTLPGGVYIAADASGRFTYTHQFGVSTASPTVNRKPAFTPDTRLVVASCTKLSTAVAVMKVVEAGMVTLDEDLRKTILPELGELQIIESIDQNGVPVLKPNDHPITLRHLLTHTSGLGYDLVDPPLMAWRAHTGTLPWTGPTIPARMSVPLQFAPGTGWRYGVGADWAGLVVERASGQELDHFLQENVWKKLGVTKATFWRHRIQKEQAAAGHEVEGEWAEEAMLIPPQAAGGAGGGLDMGVATKSDALPVAVPLQGFDMLGGLEKPSGGGGLSCTAAEYLALLKAVLTKDPSVLGETSWDELLMPQVGEGRPVGIEAWNSLNRTLKEDDQWDVNCGMNLPRSMNKSLSLAGLVSEDVFELGNGAKISKGTVLWGGMTGMTWFVDRENGLCGLAAPQVFTFGQRPLHDLNALWLQQIFKWHRDHKDQAVSALSRQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CIC6</accession>
    <name>A0A177CIC6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF171-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1162976</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class IV-like SAM-binding methyltransferase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG06618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036983.1">
        <property type="nucleotide sequence ID" value="XM_018178143.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CIC6"/>
    <dbReference type="STRING" id="1460663.A0A177CIC6"/>
    <dbReference type="GeneID" id="28761629"/>
    <dbReference type="InParanoid" id="A0A177CIC6"/>
    <dbReference type="OrthoDB" id="361029at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18086">
        <property type="entry name" value="HsC9orf114-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003750">
        <property type="entry name" value="Put_MeTrfase-C9orf114-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12150">
        <property type="entry name" value="CLASS IV SAM-BINDING METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12150:SF13">
        <property type="entry name" value="METHYLTRANSFERASE C9ORF114-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02598">
        <property type="entry name" value="Methyltrn_RNA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="alpha/beta knot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="69"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="69"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG06618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="558" mass="61913" checksum="AB24384767B1FEEC" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CJ78</accession>
    <name>A0A177CJ78_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 19">Squalene synthase</fullName>
            <shortName evidence="19">SQS</shortName>
            <shortName evidence="19">SS</shortName>
            <ecNumber evidence="4 19">2.5.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">CC84DRAFT_1204552</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="19">Catalyzes the condensation of 2 farnesyl pyrophosphate (FPP) moieties to form squalene.</text>
    </comment>
    <comment type="function">
        <text evidence="18">Squalene synthase; part of the gene cluster that mediates the biosynthesis of squalestatin S1 (SQS1, also known as zaragozic acid A), a heavily oxidized fungal polyketide that offers potent cholesterol lowering activity by targeting squalene synthase (SS). Catalyzes the condensation of 2 two farnesyl pyrophosphate moieties to form squalene. The presence of a gene encoding a squalene synthase supports the identification of the cluster as being responsible for SQS1 production and suggests a likely mechanism for self-resistance.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17 19">
            <text>2 (2E,6E)-farnesyl diphosphate + NADH + H(+) = squalene + 2 diphosphate + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:32299"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15440"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:175763"/>
            <dbReference type="EC" id="2.5.1.21"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16 19">
            <text>2 (2E,6E)-farnesyl diphosphate + NADPH + H(+) = squalene + 2 diphosphate + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:32295"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15440"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:175763"/>
            <dbReference type="EC" id="2.5.1.21"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 19">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="19">Terpene metabolism; lanosterol biosynthesis; lanosterol from farnesyl diphosphate: step 1/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 19">Belongs to the phytoene/squalene synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.21" evidence="4 19"/>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG06889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037254.1">
        <property type="nucleotide sequence ID" value="XM_018181913.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CJ78"/>
    <dbReference type="FunCoup" id="A0A177CJ78">
        <property type="interactions" value="304"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CJ78"/>
    <dbReference type="GeneID" id="28765399"/>
    <dbReference type="InParanoid" id="A0A177CJ78"/>
    <dbReference type="OrthoDB" id="431150at2759"/>
    <dbReference type="UniPathway" id="UPA00767">
        <property type="reaction ID" value="UER00751"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055056">
        <property type="term" value="F:D-glucose transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051996">
        <property type="term" value="F:squalene synthase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045338">
        <property type="term" value="P:farnesyl diphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902767">
        <property type="term" value="P:isoprenoid biosynthetic process via mevalonate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00683">
        <property type="entry name" value="Trans_IPPS_HH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.600.10:FF:000003">
        <property type="entry name" value="Farnesyl-diphosphate farnesyltransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002060">
        <property type="entry name" value="Squ/phyt_synthse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006449">
        <property type="entry name" value="Squal_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019845">
        <property type="entry name" value="Squalene/phytoene_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044844">
        <property type="entry name" value="Trans_IPPS_euk-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033904">
        <property type="entry name" value="Trans_IPPS_HH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01559">
        <property type="entry name" value="squal_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11626">
        <property type="entry name" value="FARNESYL-DIPHOSPHATE FARNESYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11626:SF2">
        <property type="entry name" value="SQUALENE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00494">
        <property type="entry name" value="SQS_PSY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00005">
        <property type="entry name" value="Isoprenoid_Synthase_Type_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01018">
        <property type="entry name" value="Squalene/Phytoene_Synthase_Lik"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01044">
        <property type="entry name" value="SQUALEN_PHYTOEN_SYN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01045">
        <property type="entry name" value="SQUALEN_PHYTOEN_SYN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="14" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="10" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="13" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="6 19" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="421"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00050857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00051754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00053206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU368088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="OAG06889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="487" mass="55464" checksum="36B7524B70D6AFD5" modified="2016-09-07" version="1">MPGVKDIAYYAVHPTQLRSIIQWKVWHNPVHERDESKESASLKRCFHFLAQTSRSFVAVILELHPDILVSVAIFYLVLRGLDTIEDDMTIPLAKKEPILRDFHNIIEQDGWTFTENGPNEKDRQLCVEFNVVIEEYKKLKPAHQAIIKDITKRMGNGMADYVKNAEFGINDNGVNTVKDYEKYCHYVAGLVGEGCTRLFVEEGKANPALLKRTELHESMGQFLQQVNIIRDIKEDFDDKRRFWPKEIWSKHVDNFEDLFKPENKAKALACSSEMILTALRRADDCLFYLAGIKEQSVFNFCAIPQSMAIATLDACFQNYDIFKRNVKITKGDACQLMLESTQNLQLVCDVFKRYTRKIHKKNNPHDPNFLQISIACGKTEQFIESIFPSQKPPVDEKKNPVNAEEAARLKKEAEETKWETIYMVSAVIGTILFISGIMLVVAWFAGARFDIALSQAKEQLGQLFGSGGSINASAPLDTKPSTDHSEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CK61</accession>
    <name>A0A177CK61_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Extracellular membrane protein CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1214472</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG07914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038279.1">
        <property type="nucleotide sequence ID" value="XM_018182630.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CK61"/>
    <dbReference type="STRING" id="1460663.A0A177CK61"/>
    <dbReference type="GeneID" id="28766116"/>
    <dbReference type="InParanoid" id="A0A177CK61"/>
    <dbReference type="OrthoDB" id="3797419at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="392"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="406"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG07914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="500" mass="50211" checksum="08883DA5FB47FC99" modified="2016-09-07" version="1">MHWHIRDFWTRTSLIISSSSHKHHHKSSSLVLSETGYLELDTTTTVPYTSTVETTVYTETPSLPHFTSVPSTVSITPSFSASTTSKSTSPGPSPTESSATESSTKVFSATTLTIIKSSESGSTTSSSLAPTTTSTSVSSTESSLKGVSETTSTKTSTATKPLETSSTKTSTETKPLETSSTKTSTESKPLETSSTKTSTETKSLETSSTKTSTETCKTCTATTTTTMSPTIFSTLTLSSTLFVLSTAIPGPPHDIPGAIAGFSNCAQDVLFPLIGKSQCNPADFPCICIELDRLDALKSVADGCPNDAAKYSDFAVSACGKTTAVITVTGSSSSSSSEAGVTTTTIPVVLSTGTPSVATSSVGPFNNGTTIVQPSKTKTEVIVQPSKTKTEVIVLPSETSKSNGTSGSGGSGSGAGSGSGAGSGSGAGSGSGAGSGKVPGSGSGSGGGSGSGASSHISPTQPEQPKQPEFSGAAVSEFGSAGMASFAGLVGVMWLAFAEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CKE9</accession>
    <name>A0A177CKE9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CC84DRAFT_655435</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG07348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037713.1">
        <property type="nucleotide sequence ID" value="XM_018187023.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CKE9"/>
    <dbReference type="FunCoup" id="A0A177CKE9">
        <property type="interactions" value="1271"/>
    </dbReference>
    <dbReference type="GeneID" id="28770509"/>
    <dbReference type="InParanoid" id="A0A177CKE9"/>
    <dbReference type="OrthoDB" id="4934715at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF49">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="23"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAG07348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="731" mass="83410" checksum="77A297C60BF11968" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CLD4</accession>
    <name>A0A177CLD4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1086976</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038710.1">
        <property type="nucleotide sequence ID" value="XM_018174180.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CLD4"/>
    <dbReference type="STRING" id="1460663.A0A177CLD4"/>
    <dbReference type="GeneID" id="28757666"/>
    <dbReference type="InParanoid" id="A0A177CLD4"/>
    <dbReference type="OrthoDB" id="1708389at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021709">
        <property type="entry name" value="DUF3292"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38694">
        <property type="entry name" value="CONSERVED EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38694:SF1">
        <property type="entry name" value="PEROXIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11696">
        <property type="entry name" value="DUF3292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="168"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="354"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="214"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="257"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="438"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="486"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="439"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG08345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="694" mass="75608" checksum="0E3A2B7D5FF1BA17" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CMV1</accession>
    <name>A0A177CMV1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CC84DRAFT_1114526</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038583.1">
        <property type="nucleotide sequence ID" value="XM_018175397.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CMV1"/>
    <dbReference type="FunCoup" id="A0A177CMV1">
        <property type="interactions" value="180"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CMV1"/>
    <dbReference type="GeneID" id="28758883"/>
    <dbReference type="InParanoid" id="A0A177CMV1"/>
    <dbReference type="OrthoDB" id="264392at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025969">
        <property type="entry name" value="ABA_GPCR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022535">
        <property type="entry name" value="Golgi_pH-regulator_cons_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015672">
        <property type="entry name" value="GPHR/GTG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15948">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR 89-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15948:SF0">
        <property type="entry name" value="GOLGI PH REGULATOR A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12430">
        <property type="entry name" value="ABA_GPCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12537">
        <property type="entry name" value="GPHR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="23"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="126"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="161"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="208"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="338"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="404"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="438"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="488"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="domain" description="Golgi pH regulator conserved" evidence="8">
        <location>
            <begin position="199"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="Abscisic acid G-protein coupled receptor-like" evidence="7">
        <location>
            <begin position="330"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="297"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAG08218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="531" mass="58807" checksum="3AEF697AD833872E" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CMY0</accession>
    <name>A0A177CMY0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1087216</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039011.1">
        <property type="nucleotide sequence ID" value="XM_018174189.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CMY0"/>
    <dbReference type="GeneID" id="28757675"/>
    <dbReference type="InParanoid" id="A0A177CMY0"/>
    <dbReference type="OrthoDB" id="3450745at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG08646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="197" mass="21685" checksum="2B39CCCE7C61DEA4" modified="2016-09-07" version="1">MSIQQRSTADIPTCGPEPQACICPAGSFFQASSSYAIYPVAAKEITRVTGQFLNTAWFGTSPDHVTGSSTTPGAKRFLYAGLPGGSSEYLITEQLTKFEPRTTRGRTNVGYYMKFQMADAPLTYNKTDGTQGLLAGSWDIVDVREINGQTLMLWSIYVCFGDAYDIQGFHESAMKNVTQILKQERKMRGDMIGPISF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CN38</accession>
    <name>A0A177CN38_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Serine hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_1162741</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LovG family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039278.1">
        <property type="nucleotide sequence ID" value="XM_018178079.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CN38"/>
    <dbReference type="STRING" id="1460663.A0A177CN38"/>
    <dbReference type="GeneID" id="28761565"/>
    <dbReference type="InParanoid" id="A0A177CN38"/>
    <dbReference type="OrthoDB" id="414698at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005645">
        <property type="entry name" value="FSH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050593">
        <property type="entry name" value="LovG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48070:SF3">
        <property type="entry name" value="ESTERASE DBAE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48070">
        <property type="entry name" value="ESTERASE OVCA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03959">
        <property type="entry name" value="FSH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine hydrolase" evidence="3">
        <location>
            <begin position="18"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAG08913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="294" mass="32828" checksum="B55395275D13689B" modified="2016-09-07" version="1">MPSTGSKIPSTIPDSTHLPRILCLHGGGVNAAIFKAQSRSLIRHLQHSFRLIWVDGPFFCDPHTDVIQVYGSYAPFRRWLRWLPEHPEIDAETCIDEIGYAIRTAMENDDRDGGQGEWVGLMGFSQGAKLSASLLLEQQARESKAVREGKTKWDVGPIGIPGLNWRFGVLLAGRAPMSNLNPSLLKSQALVSAADLSEGFQFVKEVDDEAILRQPTIHVHGMADAGLHLHRRLYKEYCEQGSTRLVEWEGAHRIPIKSDTVERVVGAIYDIAEQNEIEVSWTVNRRPSWTSATP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CN84</accession>
    <name>A0A177CN84_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Methyltransferase type 11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1162780</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039338.1">
        <property type="nucleotide sequence ID" value="XM_018178096.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CN84"/>
    <dbReference type="STRING" id="1460663.A0A177CN84"/>
    <dbReference type="GeneID" id="28761582"/>
    <dbReference type="InParanoid" id="A0A177CN84"/>
    <dbReference type="OrthoDB" id="10256176at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="2">
        <location>
            <begin position="661"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="250"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="250"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="260"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG08973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="879" mass="97627" checksum="59BCCDEC45E74613" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CNS3</accession>
    <name>A0A177CNS3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_1241036</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG09154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039519.1">
        <property type="nucleotide sequence ID" value="XM_018184040.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CNS3"/>
    <dbReference type="STRING" id="1460663.A0A177CNS3"/>
    <dbReference type="GeneID" id="28767526"/>
    <dbReference type="InParanoid" id="A0A177CNS3"/>
    <dbReference type="OrthoDB" id="5342292at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF158">
        <property type="entry name" value="MEMBRANE PROTEIN PTH11-LIKE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="101"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="182"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="44"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAG09154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="229" mass="25683" checksum="BDFAE651AA1A4434" modified="2016-09-07" version="1">MAVTPAATPPHGLESDFVHPPSEAQTVYIVMSVCLGLVTLLVAIRIYTRARITKSLWWDDWMSLLAWVFFIALLRVTFGAVENGGGVDIWNLPKSKYMHFIKYWNLIMIMARVDITLAKVAILLLYLRIFVPHQTGSRQMWFWIWFMVVFNVVYCLVLILLIQLQCVGHKTPQANGSCLDQHLLLITASVINVITEVAILVVAVVAVWGLRMPIGKKVACVAVLSFGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CNX7</accession>
    <name>A0A177CNX7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cora family metal ion transporter-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_431706</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG09214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039579.1">
        <property type="nucleotide sequence ID" value="XM_018186224.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CNX7"/>
    <dbReference type="FunCoup" id="A0A177CNX7">
        <property type="interactions" value="43"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CNX7"/>
    <dbReference type="GeneID" id="28769710"/>
    <dbReference type="InParanoid" id="A0A177CNX7"/>
    <dbReference type="OrthoDB" id="29879at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010961">
        <property type="term" value="P:intracellular magnesium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12829">
        <property type="entry name" value="Alr1p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.340:FF:000006">
        <property type="entry name" value="CorA family metal ion transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.460.20:FF:000002">
        <property type="entry name" value="Cora family metal ion transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.20">
        <property type="entry name" value="CorA soluble domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044089">
        <property type="entry name" value="Alr1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045861">
        <property type="entry name" value="CorA_cytoplasmic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045863">
        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21535">
        <property type="entry name" value="MAGNESIUM AND COBALT TRANSPORT PROTEIN/MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21535:SF55">
        <property type="entry name" value="MAGNESIUM TRANSPORTER ALR1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143865">
        <property type="entry name" value="CorA soluble domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="606"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="636"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="87"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="28"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="106"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="127"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="183"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAG09214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="663" mass="74650" checksum="9EBF74EBE52CB267" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CP65</accession>
    <name>A0A177CP65_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peroxisomal membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1193188</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG09304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039669.1">
        <property type="nucleotide sequence ID" value="XM_018181280.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CP65"/>
    <dbReference type="FunCoup" id="A0A177CP65">
        <property type="interactions" value="186"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CP65"/>
    <dbReference type="GeneID" id="28764766"/>
    <dbReference type="InParanoid" id="A0A177CP65"/>
    <dbReference type="OrthoDB" id="45930at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045046">
        <property type="term" value="P:protein import into peroxisome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006966">
        <property type="entry name" value="Peroxin-3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28080">
        <property type="entry name" value="PEROXISOMAL BIOGENESIS FACTOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28080:SF1">
        <property type="entry name" value="PEROXISOMAL BIOGENESIS FACTOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04882">
        <property type="entry name" value="Peroxin-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="16"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="470"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="470"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG09304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="530" mass="58598" checksum="91F6819C94CABDC7" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2023-06-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CPE2</accession>
    <name>A0A177CPE2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1171969</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG09384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039749.1">
        <property type="nucleotide sequence ID" value="XM_018179943.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CPE2"/>
    <dbReference type="GeneID" id="28763429"/>
    <dbReference type="InParanoid" id="A0A177CPE2"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG09384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="157" mass="18859" checksum="8AFBABF94876D248" modified="2016-09-07" version="1">MANPAMSDRGALNFLKYLGQANKNVIRDPEIWWYDRRKQLEWALKTDRSLCREYGHWTWIFKTIGSTPLHESWFGTSRSEMANFPRISSLNTNFLPPWLILIMPTLRKFHIKTTSLDHLIQYGLCRDNDPYIWTRNWWEPNQEAQDDAKYLFNMNML</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CPH8</accession>
    <name>A0A177CPH8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1240962</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG09121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039486.1">
        <property type="nucleotide sequence ID" value="XM_018184037.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CPH8"/>
    <dbReference type="STRING" id="1460663.A0A177CPH8"/>
    <dbReference type="GeneID" id="28767523"/>
    <dbReference type="InParanoid" id="A0A177CPH8"/>
    <dbReference type="OrthoDB" id="3930519at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="302"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG09121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="324" mass="34481" checksum="E8842CE95013C152" modified="2016-09-07" version="1">MANEKKETKPEKSTEANESKPDKSSGNGYSKEEVQKESSKAAKQAKEAHNKATELLQAAAAAGDPDERQKLMEEALEQQIQSKSFGKTARYLRSGTFQGMAVGAGLGIAPGASLGAITGTLVGGVSSTALGGIGAGLGAATGWMHGPFWDLGKGGGNIIKKITGNLPGWKATESQKKQLEKMLGQVNEQDTPGMDELESWESEGPSEDQKEVMENVKSKLPSLPSQGKSEETSNKGGNQEEKAQKDEQEKEQSKTGDSAKTEKSQSQGEEKENDDDEKNSETAQGAEGRKKPRKLQPKSEETSAPSDSSASAKKQPRKLEKRSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CPQ3</accession>
    <name>A0A177CPQ3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Leucine-rich repeat domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1255369</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG09286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039651.1">
        <property type="nucleotide sequence ID" value="XM_018184534.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CPQ3"/>
    <dbReference type="STRING" id="1460663.A0A177CPQ3"/>
    <dbReference type="GeneID" id="28768020"/>
    <dbReference type="InParanoid" id="A0A177CPQ3"/>
    <dbReference type="OrthoDB" id="3783332at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056867">
        <property type="entry name" value="LRR_15"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24969">
        <property type="entry name" value="LRR_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Leucine-rich repeat" evidence="2">
        <location>
            <begin position="311"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="494"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG09286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="514" mass="57672" checksum="4E1F3723D76A5F56" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2023-06-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CQ04</accession>
    <name>A0A177CQ04_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_433819</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG09311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039676.1">
        <property type="nucleotide sequence ID" value="XM_018186243.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CQ04"/>
    <dbReference type="GeneID" id="28769729"/>
    <dbReference type="InParanoid" id="A0A177CQ04"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG09311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="83" mass="9253" checksum="85B48EF14B287682" modified="2016-09-07" version="1">MTCARVTLHRKHKLLPSHISPRGSYKLSLAASACLIPIFNFATLLCDTKAACRTLSPEQFCSHVRTLWPRPADQCTPTHLQPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CQB4</accession>
    <name>A0A177CQB4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Ras-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CC84DRAFT_1160818</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Ras family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG09713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040078.1">
        <property type="nucleotide sequence ID" value="XM_018177587.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CQB4"/>
    <dbReference type="FunCoup" id="A0A177CQB4">
        <property type="interactions" value="479"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CQB4"/>
    <dbReference type="GeneID" id="28761073"/>
    <dbReference type="InParanoid" id="A0A177CQB4"/>
    <dbReference type="OrthoDB" id="5976022at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04138">
        <property type="entry name" value="H_N_K_Ras_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000080">
        <property type="entry name" value="Ras-like GTPase Ras1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020849">
        <property type="entry name" value="Small_GTPase_Ras-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0636">Prenylation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="179"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OAG09713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="212" mass="23914" checksum="C9CFEC8FA3DA36C2" modified="2016-09-07" version="1">MASKFLREYKLVVVGGGGVGKSCLTIQLIQSHFVDEYDPTIEDSYRKQCVIDDEVALLDVLDTAGQEEYSAMREQYMRTGEGFLLVYSITDRQSFEEIMTFQQQILRVKDKDYFPMIVVGNKCDLDGERQVSTQEGQNLARQFGCKFIETSAKSRINVDNAFYDIVREIRRYNKEMSSYTGAQSGGQQNGVSKMGVEDGSDEKKGCCGCVVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CQG7</accession>
    <name>A0A177CQG7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_441234</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG09556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039921.1">
        <property type="nucleotide sequence ID" value="XM_018186295.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CQG7"/>
    <dbReference type="GeneID" id="28769781"/>
    <dbReference type="InParanoid" id="A0A177CQG7"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="32"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG09556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="75" mass="8092" checksum="42AF2A509837CF09" modified="2016-09-07" version="1">MHSTHAPLPINPIQTLNEPIPQLSMPPHPTHFHTTTSRSSNTTHAALYHPGGSPLPLEPIPSALSSCPFSFLHPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CRI8</accession>
    <name>A0A177CRI8_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_1183757</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG09379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039744.1">
        <property type="nucleotide sequence ID" value="XM_018180706.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CRI8"/>
    <dbReference type="STRING" id="1460663.A0A177CRI8"/>
    <dbReference type="GeneID" id="28764192"/>
    <dbReference type="InParanoid" id="A0A177CRI8"/>
    <dbReference type="OrthoDB" id="5380854at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF51">
        <property type="entry name" value="ACRIFLAVINE SENSITIVITY CONTROL PROTEIN ACR-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="12"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAG09379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="547" mass="61432" checksum="13B62B0C62418361" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CRR3</accession>
    <name>A0A177CRR3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1137908</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG09891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040256.1">
        <property type="nucleotide sequence ID" value="XM_018176172.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CRR3"/>
    <dbReference type="GeneID" id="28759658"/>
    <dbReference type="InParanoid" id="A0A177CRR3"/>
    <dbReference type="OrthoDB" id="5342184at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021986">
        <property type="entry name" value="Spherulin4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35040:SF7">
        <property type="entry name" value="FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12138">
        <property type="entry name" value="Spherulin4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="94"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="20"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG09891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="369" mass="41302" checksum="B8C2B89E3EEFE6D1" modified="2016-09-07" version="1">MLSVPNESSSRKYHPPLSPASSHGKFSSAASSREALLTTSSNDIPLRKLIAAASSSKPSRPLHTSTSNLSLQSWPGHPRQPPQNQGRRINDHTIALSVTITLAILVLIGVPLGAILPQKYVVPLPINVLVPFYVYPDHNSWERMFQAAIKHPESNFTIILSVDHGPSASVWPPGIYLAPIKRLNMLPNVQAIGYVDTEYGSRDGEKVRKDIATYAGWNNTDLGISGIFFDHTPAEDVNDARIYLKNVSATVRHTEGFLEPTIVVHNPGKVPNANMTNYQADVTVVFEGEYKSMPPREETKAKLRDLGGRRQDYAEIIHSVPRTMSRGGIRKIINGERRYVGWLYVTDRMGDNKYEWYSDRWEEFLDLTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CRS9</accession>
    <name>A0A177CRS9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_459150</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG09996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040361.1">
        <property type="nucleotide sequence ID" value="XM_018186359.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CRS9"/>
    <dbReference type="STRING" id="1460663.A0A177CRS9"/>
    <dbReference type="GeneID" id="28769845"/>
    <dbReference type="InParanoid" id="A0A177CRS9"/>
    <dbReference type="OrthoDB" id="20872at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056681">
        <property type="entry name" value="DUF7779"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053137">
        <property type="entry name" value="NLR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082:SF6">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082">
        <property type="entry name" value="ATP/GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25000">
        <property type="entry name" value="DUF7779"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
        <property type="entry name" value="NB-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13374">
        <property type="entry name" value="TPR_10"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NB-ARC" evidence="2">
        <location>
            <begin position="73"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7779" evidence="3">
        <location>
            <begin position="315"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="343"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAG09996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="635" mass="71572" checksum="FD777D91E1F81088" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CS71</accession>
    <name>A0A177CS71_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Succinate-semialdehyde dehydrogenase</fullName>
            <ecNumber evidence="8">1.2.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CC84DRAFT_1161330</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5 8">
            <text>succinate semialdehyde + NAD(+) + H2O = succinate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:13217"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57706"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.2.1.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4 8">
            <text>succinate semialdehyde + NADP(+) + H2O = succinate + NADPH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:13213"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:57706"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.2.1.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Amino-acid degradation; 4-aminobutanoate degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.16" evidence="8"/>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040740.1">
        <property type="nucleotide sequence ID" value="XM_018177704.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CS71"/>
    <dbReference type="FunCoup" id="A0A177CS71">
        <property type="interactions" value="439"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CS71"/>
    <dbReference type="GeneID" id="28761190"/>
    <dbReference type="InParanoid" id="A0A177CS71"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="UniPathway" id="UPA00733"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004777">
        <property type="term" value="F:succinate-semialdehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036243">
        <property type="term" value="F:succinate-semialdehyde dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009450">
        <property type="term" value="P:gamma-aminobutyric acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07103">
        <property type="entry name" value="ALDH_F5_SSADH_GabD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000004">
        <property type="entry name" value="Succinate-semialdehyde dehydrogenase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000005">
        <property type="entry name" value="Succinate-semialdehyde dehydrogenase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050740">
        <property type="entry name" value="Aldehyde_DH_Superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010102">
        <property type="entry name" value="Succ_semiAld_DH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01780">
        <property type="entry name" value="SSADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43353">
        <property type="entry name" value="SUCCINATE-SEMIALDEHYDE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43353:SF5">
        <property type="entry name" value="SUCCINATE-SEMIALDEHYDE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="9">
        <location>
            <begin position="25"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00050387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00052698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAG10375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="499" mass="53267" checksum="F5E3F518AD5AEFF0" modified="2016-09-07" version="1">MGHSVPQLNDKSLLKEAQTYVNGEWIAAKSGKTFEVHDPATGKTIGTQPEMDRADTEAAIAAAAAAFPEWRKTTGRQRSKLLRKWYDLMIENADDLAKLITWENGKPIADAKGEVTYAANFFEWFAEEAPRTYGSTIPASVAGNRVFTINEPVGVCGLITPWNFPAAMITRKIGPALAAGCTVVAKSPGETPFTAAALAELGHRAGIPKGVINFVTALKNTPEIGETITSSRTVKKVSFTGSTGVGKLLMKQSSDTIKKLSFELGGNSPFIVFDDADLDAAVTGAIASKFRSSGQTCVCANRIYVQSGIYDAFAEKFVEKVKGFKVGGGYDEGVTHGPLIHDRAVSKVEAHVRDAEKQGGKILIGGQKLPDLGSNFYQPTVIRDMTANMQLANEETFGPVAGLFKFETEAEVIELANASDVGLAGYFFSRDVQRCYRIAEALEVGMVGVNTGLISDPASPFGGVKESGFGREGSMLGIKEYEVTKMVTLGGMGESLQGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CSE2</accession>
    <name>A0A177CSE2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1202894</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040810.1">
        <property type="nucleotide sequence ID" value="XM_018181798.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CSE2"/>
    <dbReference type="GeneID" id="28765284"/>
    <dbReference type="InParanoid" id="A0A177CSE2"/>
    <dbReference type="OrthoDB" id="10433496at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="115"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="70"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG10445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="224" mass="24292" checksum="761E7167C228862E" modified="2016-09-07" version="1">MSLRWSKRMFPLARPSGGDLYARGSRPESNPCLDGCSENNFRRAAFAVSRSGSRRPAYHVRREQGTEGATTSTSLSRTTTTSIEATATPSALSIESPSPSSSTTATAAPSNRPNFAAIAGAAAGGFVFLLLVGIIIFFWLHTQKSRRHHNRTFERRVSDSGDAGEMAQKQLVRVSIVAEEPPSMRPALSMQSHSRIGTTQLRTSICPNHRPLPGKRLTDLQLGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CSI5</accession>
    <name>A0A177CSI5_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Calcium-transporting ATPase</fullName>
            <ecNumber evidence="17">7.2.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">CC84DRAFT_1235592</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Catalyzes the hydrolysis of ATP coupled with the transport of calcium.</text>
    </comment>
    <comment type="function">
        <text evidence="16">This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. Transports the calcium to the vacuole and participates in the control of the cytosolic free calcium.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15 17">
            <text>Ca(2+)(in) + ATP + H2O = Ca(2+)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18105"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.2.2.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="17">Membrane</location>
            <topology evidence="17">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="17">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.10" evidence="17"/>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG09737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040102.1">
        <property type="nucleotide sequence ID" value="XM_018183852.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CSI5"/>
    <dbReference type="FunCoup" id="A0A177CSI5">
        <property type="interactions" value="464"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CSI5"/>
    <dbReference type="GeneID" id="28767338"/>
    <dbReference type="InParanoid" id="A0A177CSI5"/>
    <dbReference type="OrthoDB" id="3352408at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005388">
        <property type="term" value="F:P-type calcium transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02081">
        <property type="entry name" value="P-type_ATPase_Ca_PMCA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000028">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000031">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000018">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006408">
        <property type="entry name" value="P-type_ATPase_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01517">
        <property type="entry name" value="ATPase-IIB_Ca"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24093:SF346">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24093">
        <property type="entry name" value="CATION TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00120">
        <property type="entry name" value="HATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 17" id="KW-0106">Calcium</keyword>
    <keyword evidence="4 17" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="13 17" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 17" id="KW-0813">Transport</keyword>
    <keyword evidence="3" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="240"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="279"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="451"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="492"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="991"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1029"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1066"/>
            <end position="1086"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1098"/>
            <end position="1120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1126"/>
            <end position="1146"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="21">
        <location>
            <begin position="213"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase A" evidence="19">
        <location>
            <begin position="316"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase C-terminal" evidence="20">
        <location>
            <begin position="948"/>
            <end position="1118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="47"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1150"/>
            <end position="1174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="1156"/>
            <end position="1169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00059328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU361146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF00689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF00690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="OAG09737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="1190" mass="128228" checksum="165C9FB73324F252" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CT44</accession>
    <name>A0A177CT44_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PhoD-like phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_456500</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG09919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040284.1">
        <property type="nucleotide sequence ID" value="XM_018186352.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CT44"/>
    <dbReference type="FunCoup" id="A0A177CT44">
        <property type="interactions" value="73"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CT44"/>
    <dbReference type="GeneID" id="28769838"/>
    <dbReference type="InParanoid" id="A0A177CT44"/>
    <dbReference type="OrthoDB" id="9999821at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07389">
        <property type="entry name" value="MPP_PhoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.70">
        <property type="entry name" value="PhoD-like phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018946">
        <property type="entry name" value="PhoD-like_MPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038607">
        <property type="entry name" value="PhoD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043904">
        <property type="entry name" value="PhoD_2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46689">
        <property type="entry name" value="MEMBRANE PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46689:SF3">
        <property type="entry name" value="PHOD-LIKE PHOSPHATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19050">
        <property type="entry name" value="PhoD_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PhoD-like phosphatase" evidence="2">
        <location>
            <begin position="141"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="PhoD-like phosphatase" evidence="2">
        <location>
            <begin position="370"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="PhoD-like phosphatase" evidence="2">
        <location>
            <begin position="451"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="310"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="579"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="310"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="628"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="648"/>
            <end position="661"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG09919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="734" mass="81026" checksum="1101CEC86408B721" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CT56</accession>
    <name>A0A177CT56_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Class I glutamine amidotransferase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1139448</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041078.1">
        <property type="nucleotide sequence ID" value="XM_018176239.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CT56"/>
    <dbReference type="STRING" id="1460663.A0A177CT56"/>
    <dbReference type="GeneID" id="28759725"/>
    <dbReference type="InParanoid" id="A0A177CT56"/>
    <dbReference type="OrthoDB" id="543156at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052158">
        <property type="entry name" value="INH-QAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43130">
        <property type="entry name" value="ARAC-FAMILY TRANSCRIPTIONAL REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43130:SF3">
        <property type="entry name" value="HTH-TYPE TRANSCRIPTIONAL REGULATOR RV1931C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DJ-1/PfpI" evidence="2">
        <location>
            <begin position="16"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="206"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG10713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="300" mass="32671" checksum="EC6454952EE74B2F" modified="2016-09-07" version="1">MSAIADNNDGPVETVQVLFALYPGYNTLDVAGPLEVLSRSLHNPKDKASKAFKVQFAGTAAAMTSVQGLTIKADMDYEDANDELEDFDVIIVPGGEGVFDVLKNKSEPLGLLSKYVELQEKNPAKERTVLAVDIGTLLLAQQGMLEGLAATTHPDYYTRLEQACQEASSRDLSMRTDVMEERYVVNNARFDLGENPDDNPYIIRKTRGGDGDNTQGGRRKSIARKGSNAWQESRRRESIARRAKLPLGGMRIITTGGVTAGLDASLYLVGSLVSHDSALEVARVMQYSWVKGVTVDAIDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CTZ4</accession>
    <name>A0A177CTZ4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_482418</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040725.1">
        <property type="nucleotide sequence ID" value="XM_018186447.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CTZ4"/>
    <dbReference type="GeneID" id="28769933"/>
    <dbReference type="InParanoid" id="A0A177CTZ4"/>
    <dbReference type="OrthoDB" id="10352218at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG10360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="182" mass="20948" checksum="32AB93AAE3F1EF3F" modified="2016-09-07" version="1">MSASLHTRMQAASREDDEVTTKTIDLHGCQLEHTRISGISLGYTFINIILFNHNRLHTSTNIWYARSFMVLSSLSTQLPFCLCRREWQPDITRDCIKGSRHSLQQYLTRFVPSRTLVLFALHQRLNTGVTDIPRRFTNLGKAAYKRLGYRWPDQIIDMGLRERRSITGKGLGERCMAGAFVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CUC3</accession>
    <name>A0A177CUC3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1158755</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG11134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041499.1">
        <property type="nucleotide sequence ID" value="XM_018177064.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CUC3"/>
    <dbReference type="GeneID" id="28760550"/>
    <dbReference type="InParanoid" id="A0A177CUC3"/>
    <dbReference type="OrthoDB" id="10349548at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG11134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="92" mass="10150" checksum="35AE840A21D13946" modified="2016-09-07" version="1">MSLRYRSLSYKASVLPTSPICLIVLSEETETCSLGVGYKQIVPSSRHLLELIIPIFVVEPLHQRVRLCQGNEATCPDNIIAMASVSVDAYTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CV43</accession>
    <name>A0A177CV43_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">FAD-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CC84DRAFT_1158973</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG11425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041790.1">
        <property type="nucleotide sequence ID" value="XM_018177108.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CV43"/>
    <dbReference type="STRING" id="1460663.A0A177CV43"/>
    <dbReference type="GeneID" id="28760594"/>
    <dbReference type="InParanoid" id="A0A177CV43"/>
    <dbReference type="OrthoDB" id="9983560at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050432">
        <property type="entry name" value="FAD-linked_Oxidoreductases_BP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13878:SF91">
        <property type="entry name" value="FAD BINDING DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G12070)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13878">
        <property type="entry name" value="GULONOLACTONE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012520381" evidence="3">
        <location>
            <begin position="16"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="4">
        <location>
            <begin position="117"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAG11425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="570" mass="61096" checksum="DA9FF851812199B0" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CVE3</accession>
    <name>A0A177CVE3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">UPF0103-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1161578</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MEMO1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041074.1">
        <property type="nucleotide sequence ID" value="XM_018177778.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CVE3"/>
    <dbReference type="FunCoup" id="A0A177CVE3">
        <property type="interactions" value="502"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CVE3"/>
    <dbReference type="GeneID" id="28761264"/>
    <dbReference type="InParanoid" id="A0A177CVE3"/>
    <dbReference type="OrthoDB" id="417112at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07361">
        <property type="entry name" value="MEMO_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.830.10">
        <property type="entry name" value="LigB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00055">
        <property type="entry name" value="MEMO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002737">
        <property type="entry name" value="MEMO1_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR04336">
        <property type="entry name" value="AmmeMemoSam_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11060">
        <property type="entry name" value="PROTEIN MEMO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11060:SF0">
        <property type="entry name" value="PROTEIN MEMO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01875">
        <property type="entry name" value="Memo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG10709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="333" mass="36425" checksum="0CF6B30ABAD39C34" modified="2016-09-07" version="1">MAPAIRDPSHAGSWYTDDSATLSQQLDGWLSKVPSLTTPIGSASSKQGDVSIPVQKARAIIAPHAGYSYSGPAAAWAYKSADWANAKRVFLLGPSHHWGLPGAATTGCSEYGTPLGNLTVDTELVGTIRKEWNLKTMSRQQDEDEHSLEMHLPYIYKMLSLHNSAFKSDASSVPLVPILVGATNSATERDLGSKLAHYLADPTNLFVISSDFCHWGSRFRYTYYQLPDGSAREIRSSSEVKKDYPIHESIKAVDFESIDAVESGEHKQFLKQLQETGNTVCGRHPIGVFMAAVEQASGLQGDGKFRFLRYERSSEVVSVRDSSVSYASAFAIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CWN8</accession>
    <name>A0A177CWN8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">DUF726-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CC84DRAFT_1132687</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMCO4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG11149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041514.1">
        <property type="nucleotide sequence ID" value="XM_018175941.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CWN8"/>
    <dbReference type="GeneID" id="28759427"/>
    <dbReference type="InParanoid" id="A0A177CWN8"/>
    <dbReference type="OrthoDB" id="277931at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007941">
        <property type="entry name" value="DUF726"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17920:SF22">
        <property type="entry name" value="DUF726 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_2G12860)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17920">
        <property type="entry name" value="TRANSMEMBRANE AND COILED-COIL DOMAIN-CONTAINING PROTEIN 4 TMCO4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05277">
        <property type="entry name" value="DUF726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="289"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="327"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="699"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="905"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="651"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="711"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="728"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="747"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="805"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="827"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="905"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="927"/>
            <end position="937"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAG11149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="937" mass="101838" checksum="3901CDA067F71833" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CZL8</accession>
    <name>A0A177CZL8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1255102</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018043319.1">
        <property type="nucleotide sequence ID" value="XM_018184506.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CZL8"/>
    <dbReference type="GeneID" id="28767992"/>
    <dbReference type="InParanoid" id="A0A177CZL8"/>
    <dbReference type="OrthoDB" id="5337308at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008058795" evidence="1">
        <location>
            <begin position="19"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG12954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="331" mass="36744" checksum="611EA515311FA725" modified="2016-09-07" version="1">MKLTTTTTLALLASTACGFYAPQVVRSLLSPQDPPIHLARRDDEPASDDVWNKAKCIGGQFFKAFPLSDKDAGQEYSPKKDSVQSKWKGDLKDGLKKWGWTQNTLLKSVCEFDESALGKGWVDAAKQLNIGTEGWKDIWCYRFSHGTLWDVAADKTYNADNKDYPYTGAYAQFGINDDDGVILAMDNLMPSSAIKKNKQRDPQDGEVPALQSLSDLLWGGWYRGSQPDTSNNENVKNLKYLISLSVTNSESLSIIRRALKAKNKVTASLWPGDNFDISTAEGKALLGSPNGKRFGYLLAQRKDDVGIKKIDSVTVFRGKDHSNPILIFYVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CZZ8</accession>
    <name>A0A177CZZ8_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Elongin-C</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CC84DRAFT_1135195</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Essential component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. Controls sulfur metabolite repression, probably by mediating the inactivation or degradation of the metR transcription factor.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SKP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042857.1">
        <property type="nucleotide sequence ID" value="XM_018176052.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CZZ8"/>
    <dbReference type="FunCoup" id="A0A177CZZ8">
        <property type="interactions" value="663"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CZZ8"/>
    <dbReference type="GeneID" id="28759538"/>
    <dbReference type="InParanoid" id="A0A177CZZ8"/>
    <dbReference type="OrthoDB" id="249087at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18321">
        <property type="entry name" value="BTB_POZ_EloC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000035">
        <property type="entry name" value="Elongin C transcription elongation factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039948">
        <property type="entry name" value="ELC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001232">
        <property type="entry name" value="SKP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016073">
        <property type="entry name" value="Skp1_comp_POZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20648">
        <property type="entry name" value="ELONGIN-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03931">
        <property type="entry name" value="Skp1_POZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00512">
        <property type="entry name" value="Skp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SKP1 component POZ" evidence="6">
        <location>
            <begin position="12"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00045385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAG12492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="104" mass="11619" checksum="D2D482FC08D91956" modified="2016-09-07" version="1">MSADPKPTSAYVTLVSNDGYEFKILRDAACIAGTIKKAFDQSSGFREVSENRMELPTINGVVLEKVCEYLYYNQKHAESKDVPDLEIPPELCLELLIAADYLDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177D011</accession>
    <name>A0A177D011_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CC84DRAFT_1159771</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042825.1">
        <property type="nucleotide sequence ID" value="XM_018177325.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177D011"/>
    <dbReference type="STRING" id="1460663.A0A177D011"/>
    <dbReference type="GeneID" id="28760811"/>
    <dbReference type="InParanoid" id="A0A177D011"/>
    <dbReference type="OrthoDB" id="21225at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009927">
        <property type="term" value="F:histidine phosphotransfer kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43047:SF72">
        <property type="entry name" value="OSMOSENSING HISTIDINE PROTEIN KINASE SLN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43047">
        <property type="entry name" value="TWO-COMPONENT HISTIDINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase" evidence="8">
        <location>
            <begin position="235"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="9">
        <location>
            <begin position="761"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="639"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="715"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="681"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="6">
        <location>
            <position position="821"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAG12460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="897" mass="98310" checksum="95127A71A183CA0A" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177D119</accession>
    <name>A0A177D119_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1227494</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018043195.1">
        <property type="nucleotide sequence ID" value="XM_018183615.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177D119"/>
    <dbReference type="STRING" id="1460663.A0A177D119"/>
    <dbReference type="GeneID" id="28767101"/>
    <dbReference type="InParanoid" id="A0A177D119"/>
    <dbReference type="OrthoDB" id="30417at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="185"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="356"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="835"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="257"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="57"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="362"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="406"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="443"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="470"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="914"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="944"/>
            <end position="955"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG12830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="982" mass="106056" checksum="510F2F4646B31696" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BU66</accession>
    <name>A0A177BU66_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CC84DRAFT_1191456</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441563">
        <property type="protein sequence ID" value="OAF98963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029329.1">
        <property type="nucleotide sequence ID" value="XM_018181183.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BU66"/>
    <dbReference type="GeneID" id="28764669"/>
    <dbReference type="InParanoid" id="A0A177BU66"/>
    <dbReference type="OrthoDB" id="419616at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504:SF6">
        <property type="entry name" value="MULTIDRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G08740)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="56"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="125"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="154"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="184"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="222"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="298"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="338"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="370"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="400"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="440"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="475"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAF98963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="527" mass="57023" checksum="7338669B60AC2073" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BUQ9</accession>
    <name>A0A177BUQ9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF7770 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1170075</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441578">
        <property type="protein sequence ID" value="OAF98461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018028827.1">
        <property type="nucleotide sequence ID" value="XM_018179833.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BUQ9"/>
    <dbReference type="STRING" id="1460663.A0A177BUQ9"/>
    <dbReference type="GeneID" id="28763319"/>
    <dbReference type="InParanoid" id="A0A177BUQ9"/>
    <dbReference type="OrthoDB" id="3527137at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056672">
        <property type="entry name" value="DUF7770"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24968">
        <property type="entry name" value="DUF7770"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7770" evidence="1">
        <location>
            <begin position="6"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAF98461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="163" mass="19152" checksum="1363450B73F0980C" modified="2016-09-07" version="1">MFYTLRVCIHTTGRQPNGMSDNHVSVFLLLGENEGSVRLNMTTEEGDRSGVLVWSQEVYQLSNSQITHFDYRLRYTMQVGALYAWIRSWGLQRYVFSGGGSGCRFWVYTLLLKLKEIQYLDDGLPEDAWHKLSWQYSREAAPRVIEIKQGTWLSLKEWEDEWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BVU0</accession>
    <name>A0A177BVU0_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 6">Polyadenylation factor subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_1157110</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for 3'-end cleavage and polyadenylation of pre-mRNAs. Also involved in chromosome segregation where it has a role in chromosome attachment to the mitotic spindle.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441562">
        <property type="protein sequence ID" value="OAF99225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029591.1">
        <property type="nucleotide sequence ID" value="XM_018176998.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BVU0"/>
    <dbReference type="FunCoup" id="A0A177BVU0">
        <property type="interactions" value="231"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177BVU0"/>
    <dbReference type="GeneID" id="28760484"/>
    <dbReference type="InParanoid" id="A0A177BVU0"/>
    <dbReference type="OrthoDB" id="16717at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0180010">
        <property type="term" value="P:co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:002010">
        <property type="entry name" value="WD40 repeat-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045245">
        <property type="entry name" value="Pfs2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22836:SF0">
        <property type="entry name" value="PRE-MRNA 3' END PROCESSING PROTEIN WDR33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22836">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="79"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="121"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="162"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="204"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="289"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="359"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="411"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="418"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="429"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="449"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="459"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="483"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00026154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU369034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAF99225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="541" mass="59979" checksum="2B5177C0A8B7DD7D" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BVY1</accession>
    <name>A0A177BVY1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1210526</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441563">
        <property type="protein sequence ID" value="OAF99090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029456.1">
        <property type="nucleotide sequence ID" value="XM_018182294.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BVY1"/>
    <dbReference type="GeneID" id="28765780"/>
    <dbReference type="InParanoid" id="A0A177BVY1"/>
    <dbReference type="OrthoDB" id="3761807at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAF99090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="197" mass="21218" checksum="D0C9A2D378E89D5E" modified="2016-09-07" version="1">MYDLNEGQQYPDPGLCNRSASRPPHLNQTVCGCRCGRASGHSRGSDDDDRQNDDTLTLVGSDTSDNEFGFRSEATLDEAVDTSRILASQSPFQEGFSRVSSPGMPAGHSLYGSPGSESDYSDTADSMDNEPSSDAHSEMTADSRSVHPMSPGPGQGAWADLEYHFLARPLRLTPQAQYCRGVVASHLILDDDQCLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BX56</accession>
    <name>A0A177BX56_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_1052609</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441560">
        <property type="protein sequence ID" value="OAF99894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030260.1">
        <property type="nucleotide sequence ID" value="XM_018173498.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BX56"/>
    <dbReference type="GeneID" id="28756984"/>
    <dbReference type="InParanoid" id="A0A177BX56"/>
    <dbReference type="OrthoDB" id="10262656at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504:SF6">
        <property type="entry name" value="MULTIDRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G08740)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="49"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="142"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="196"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="306"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="364"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="398"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="429"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="501"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="11"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAF99894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="536" mass="58037" checksum="8AD077D01765B3C7" modified="2016-09-07" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BYP0</accession>
    <name>A0A177BYP0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1222130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441559">
        <property type="protein sequence ID" value="OAG00644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031009.1">
        <property type="nucleotide sequence ID" value="XM_018183336.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BYP0"/>
    <dbReference type="GeneID" id="28766822"/>
    <dbReference type="InParanoid" id="A0A177BYP0"/>
    <dbReference type="OrthoDB" id="3790566at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG00644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="244" mass="28052" checksum="0A53AAB3948BDA10" modified="2016-09-07" version="1">MPKLMWIGGCDMPAPVKRKTKDTIIVKGVDGLTFGLKCDTKALLESKSKIWFWTGCDNKHKLFDKLSCEWNLCPMVNTRLKEDISGLLDKSNRIAMVCITNFFDDEAADFVYFVKGYKNLANFLKLTFSGRAYNDPCFATPLQNFTFKKLIESPGLDCLALECVGKTETKGLRWLYLYKSAVNAWDKLEFDNEKYMTIKERLNRPGPMVEELSDTEEDTPSDTTDDDDEEKEVDEDEYEDLDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BYP5</accession>
    <name>A0A177BYP5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">TBCC-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CC84DRAFT_1190968</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TBCC family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441561">
        <property type="protein sequence ID" value="OAF99546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029912.1">
        <property type="nucleotide sequence ID" value="XM_018181157.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BYP5"/>
    <dbReference type="STRING" id="1460663.A0A177BYP5"/>
    <dbReference type="GeneID" id="28764643"/>
    <dbReference type="InParanoid" id="A0A177BYP5"/>
    <dbReference type="OrthoDB" id="194775at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007023">
        <property type="term" value="P:post-chaperonin tubulin folding pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007021">
        <property type="term" value="P:tubulin complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1250">
        <property type="entry name" value="Tubulin Binding Cofactor C, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017901">
        <property type="entry name" value="C-CAP_CF_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016098">
        <property type="entry name" value="CAP/MinC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006599">
        <property type="entry name" value="CARP_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027684">
        <property type="entry name" value="TBCC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038397">
        <property type="entry name" value="TBCC_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012945">
        <property type="entry name" value="Tubulin-bd_cofactor_C_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15139">
        <property type="entry name" value="TUBULIN FOLDING COFACTOR C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15139:SF0">
        <property type="entry name" value="TUBULIN-SPECIFIC CHAPERONE C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07986">
        <property type="entry name" value="TBCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00673">
        <property type="entry name" value="CARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51329">
        <property type="entry name" value="C_CAP_COFACTOR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C-CAP/cofactor C-like" evidence="6">
        <location>
            <begin position="118"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="95"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="300"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAF99546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="329" mass="35683" checksum="36F9D8A709FCBB7E" modified="2016-09-07" version="1">MSRLSSTSPTERPDAIDHCLAGISRLSSEVKDASSYIPAYDQRTYGDAIKALQEKLQNVRAELGAGPKKFKFTTKKNRSAISIGEAAEMAQNRRLLGPGGGAWDSSAGSSAVNSAFSPTPLEKLSPGEEKRELEALKLEKNGAEAVGVKVEDRDGEHVVLPTSEAQSGSSGVVSNVRGSVVDLSAPTMSGGSFATLTLKNIQRSLVVTGRVAGPIHMTDLKNSVIIMSCRQFRMHGSKKVDVYLHCSSRPIIEDCEDIRFAPLPQIYMTADLTSSTNQWDQIDDFKWLKAEASPHWSILPEPERAQEKLPGQDNQGPDNILRAFRVSTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BZW5</accession>
    <name>A0A177BZW5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1168132</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441558">
        <property type="protein sequence ID" value="OAG00923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031288.1">
        <property type="nucleotide sequence ID" value="XM_018179324.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BZW5"/>
    <dbReference type="STRING" id="1460663.A0A177BZW5"/>
    <dbReference type="GeneID" id="28762810"/>
    <dbReference type="InParanoid" id="A0A177BZW5"/>
    <dbReference type="OrthoDB" id="4034134at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038872">
        <property type="entry name" value="Put_GTT3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41807">
        <property type="entry name" value="GLUTATHIONE TRANSFERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41807:SF1">
        <property type="entry name" value="GLUTATHIONE TRANSFERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="246"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="290"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="348"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG00923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="369" mass="40907" checksum="E18ADDE6419E89C6" modified="2016-09-07" version="1">MSHSWLQRKRKGELLELAQKASIPDADTLLKDDLVAALEETLEANETTFAKQRAFSEFYGRGGSPIKRERSSPDAVVLTKTRSRRQTLNRNGDSPDGTSTPDRPSVVSRALAKTPREVSQVTRRVSERVTEATPRAPQADLRATEVNLPASPAQLADFADESFQVVKERATEIWDKTRIDEAKEWLRETASSVSAIQTLILILEAATLQYNTLTDTHYLFDSPATTGFNAREVRFPNLTKLAGSGWWGPATLWSLTNWALPLIFSYFFNLTLRTNTRHKSSKTQYTIDPFTFNIAKAILAYSAYYVYTTADASLLGQPNTVLAQTPGWGPFSESSVATVRDNILGGYYGIQIGSLVGVLVSLYDAALKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BZY6</accession>
    <name>A0A177BZY6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Vegetative incompatibility protein HET-E-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_1199127</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441558">
        <property type="protein sequence ID" value="OAG01104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031469.1">
        <property type="nucleotide sequence ID" value="XM_018181602.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BZY6"/>
    <dbReference type="STRING" id="1460663.A0A177BZY6"/>
    <dbReference type="GeneID" id="28765088"/>
    <dbReference type="InParanoid" id="A0A177BZY6"/>
    <dbReference type="OrthoDB" id="674604at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50837">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="NACHT" evidence="3">
        <location>
            <begin position="197"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="2">
        <location>
            <begin position="642"/>
            <end position="683"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAG01104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="758" mass="84154" checksum="2727F282ABC007F1" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C053</accession>
    <name>A0A177C053_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Glycoside hydrolase/deacetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CC84DRAFT_363788</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KV441560">
        <property type="protein sequence ID" value="OAG00232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030597.1">
        <property type="nucleotide sequence ID" value="XM_018185928.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C053"/>
    <dbReference type="FunCoup" id="A0A177C053">
        <property type="interactions" value="40"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177C053"/>
    <dbReference type="GeneID" id="28769414"/>
    <dbReference type="InParanoid" id="A0A177C053"/>
    <dbReference type="OrthoDB" id="407355at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10951">
        <property type="entry name" value="CE4_ClCDA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.10">
        <property type="entry name" value="Endochitinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.370">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001002">
        <property type="entry name" value="Chitin-bd_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018371">
        <property type="entry name" value="Chitin-binding_1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036861">
        <property type="entry name" value="Endochitinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46471">
        <property type="entry name" value="CHITIN DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46471:SF2">
        <property type="entry name" value="CHITIN DEACETYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57016">
        <property type="entry name" value="Plant lectins/antimicrobial peptides"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00026">
        <property type="entry name" value="CHIT_BIND_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50941">
        <property type="entry name" value="CHIT_BIND_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2 8" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="7" id="KW-0170">Cobalt</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Chitin-binding type-1" evidence="9">
        <location>
            <begin position="26"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="NodB homology" evidence="10">
        <location>
            <begin position="104"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="36"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="41"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OAG00232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="353" mass="39515" checksum="9BF889AEF91B0D58" modified="2016-09-07" version="1">MRHLPRHMIEELQSYSASHLPKRDTNKKCGPGVGFCDPGDCCSPVGYCGRGSQYCASPNCQIDYSNGCDATSKPLGESTLNVSRPLIGNVTYDGAGIDHCKNPGTIALTFDDGPYNYTSHLLDVLGAYGAKATFFITGNNLGKGQIDIEETGWPDIIRRMHAEGHQIAGHSWGHQNMSSLNETEQVRQVEYLEMAIRNILGFFPTYFRPPYDDCHNGCQTVLKRMGYHITYQNVVNNDWQNDEGSKIEISKEKFVASMRQTTPRDANHIFLMHDTHYQSSWNLTSYMLDYFELFNFSRSVTVGECMGDAPENWYRAAGGAANHSLLLRKSRGSTLQYSTLLLACTQLIVNIFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C091</accession>
    <name>A0A177C091_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NAD(P)-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1168057</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441558">
        <property type="protein sequence ID" value="OAG00826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031191.1">
        <property type="nucleotide sequence ID" value="XM_018179311.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C091"/>
    <dbReference type="GeneID" id="28762797"/>
    <dbReference type="InParanoid" id="A0A177C091"/>
    <dbReference type="OrthoDB" id="3539286at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG00826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="269" mass="30090" checksum="D4309F812C462BC5" modified="2016-09-07" version="1">MPCLTTPKSILITSVSGGIGSHLVPLLFDQSPQPKLVLPTRNAENLKSALLSISKAGQYVFLPQISVRDPVWVESLSKDNELNTIFLYLTGSDEMTTALILLDAIRRIPAIKKLAYPSSIGEFTSETDSRIPSARVRYPRQLAKAIIEQRLKYRPLDLEWTILGSTIFFANDNMQISNIPSKGGLSGLSRHGVSRIALSEIALRARNAMYDTNGAWHGRKFQLGKKNLYISENFTQIWSKALVKPIDNTRKSNRSGAAVEEDDAWRYWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C0Y5</accession>
    <name>A0A177C0Y5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Concanavalin A-like lectin/glucanase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_1129187</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the glycosyl hydrolase 12 (cellulase H) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441559">
        <property type="protein sequence ID" value="OAG00468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030833.1">
        <property type="nucleotide sequence ID" value="XM_018175822.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C0Y5"/>
    <dbReference type="STRING" id="1460663.A0A177C0Y5"/>
    <dbReference type="GeneID" id="28759308"/>
    <dbReference type="InParanoid" id="A0A177C0Y5"/>
    <dbReference type="OrthoDB" id="89349at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008810">
        <property type="term" value="F:cellulase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013319">
        <property type="entry name" value="GH11/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002594">
        <property type="entry name" value="GH12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34002">
        <property type="entry name" value="BLR1656 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34002:SF10">
        <property type="entry name" value="PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01670">
        <property type="entry name" value="Glyco_hydro_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0430">Lectin</keyword>
    <keyword evidence="2" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008057571" evidence="3">
        <location>
            <begin position="17"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAG00468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="253" mass="27535" checksum="A3C03BAF93A4D31B" modified="2016-09-07" version="1">MLFQLTLAGLLTVAAASPVAAPVTPVRRQAATLCDQYGYYAANGYEFNNNNWGKGAASSGSQCTTVQSTSSSGVSWSTNWNWQGGQNNVKSYANAGKQFAKGLVIANIKSMPTNIQWDYQPRDIRANVAYDVFTAADPNHDKSSGDYELMIWLARIGGVYPIGNKVTTVNVAGYSWDLYVGPNGSMKVFSFIPSDGSWKLSFNADVKQFFNYLAQNQGYPINNQNLIVFQQGTEPFTGAAKYTVNSYSASINV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C1J5</accession>
    <name>A0A177C1J5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CC84DRAFT_1262688</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441557">
        <property type="protein sequence ID" value="OAG01654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032019.1">
        <property type="nucleotide sequence ID" value="XM_018185166.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C1J5"/>
    <dbReference type="STRING" id="1460663.A0A177C1J5"/>
    <dbReference type="GeneID" id="28768652"/>
    <dbReference type="InParanoid" id="A0A177C1J5"/>
    <dbReference type="OrthoDB" id="10031169at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042277">
        <property type="term" value="F:peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043171">
        <property type="term" value="P:peptide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09601">
        <property type="entry name" value="M1_APN-Q_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.390.10:FF:000001">
        <property type="entry name" value="Aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.50.20:FF:000002">
        <property type="entry name" value="Aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1730:FF:000002">
        <property type="entry name" value="Aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1910:FF:000004">
        <property type="entry name" value="Aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="entry name" value="Neutral Protease Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="entry name" value="tricorn interacting facor f3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045357">
        <property type="entry name" value="Aminopeptidase_N-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009598">
        <property type="entry name" value="BCALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024571">
        <property type="entry name" value="ERAP1-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034016">
        <property type="entry name" value="M1_APN-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001930">
        <property type="entry name" value="Peptidase_M1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050344">
        <property type="entry name" value="Peptidase_M1_aminopeptidases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533:SF171">
        <property type="entry name" value="AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533">
        <property type="entry name" value="PROTEASE M1 ZINC METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06726">
        <property type="entry name" value="BC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11838">
        <property type="entry name" value="ERAP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17900">
        <property type="entry name" value="Peptidase_M1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00756">
        <property type="entry name" value="ALADIPTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01396">
        <property type="entry name" value="BC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="Leukotriene A4 hydrolase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6 9" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="Aminopeptidase N-like N-terminal" evidence="14">
        <location>
            <begin position="142"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M1 membrane alanine aminopeptidase" evidence="12">
        <location>
            <begin position="380"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="domain" description="ERAP1-like C-terminal" evidence="13">
        <location>
            <begin position="675"/>
            <end position="990"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="453"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="452"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="456"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="475"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="10">
        <location>
            <position position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF11838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF17900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OAG01654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="1014" mass="114290" checksum="47E7DDCCAA1949A7" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C1N5</accession>
    <name>A0A177C1N5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">4-coumarate-CoA ligase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CC84DRAFT_1155570</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441559">
        <property type="protein sequence ID" value="OAG00637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031002.1">
        <property type="nucleotide sequence ID" value="XM_018176940.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C1N5"/>
    <dbReference type="STRING" id="1460663.A0A177C1N5"/>
    <dbReference type="GeneID" id="28760426"/>
    <dbReference type="InParanoid" id="A0A177C1N5"/>
    <dbReference type="OrthoDB" id="6509636at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016405">
        <property type="term" value="F:CoA-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05911">
        <property type="entry name" value="Firefly_Luc_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096:SF149">
        <property type="entry name" value="AMP-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="3">
        <location>
            <begin position="29"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="4">
        <location>
            <begin position="452"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAG00637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="553" mass="61399" checksum="502235D724FA61DD" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C1P0</accession>
    <name>A0A177C1P0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Carbohydrate oxidase from Microdochium Nivale in complex with substrate analogue</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_1127353</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441557">
        <property type="protein sequence ID" value="OAG01563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031928.1">
        <property type="nucleotide sequence ID" value="XM_018175769.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C1P0"/>
    <dbReference type="SMR" id="A0A177C1P0"/>
    <dbReference type="STRING" id="1460663.A0A177C1P0"/>
    <dbReference type="GeneID" id="28759255"/>
    <dbReference type="InParanoid" id="A0A177C1P0"/>
    <dbReference type="OrthoDB" id="415825at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF39">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008057601" evidence="6">
        <location>
            <begin position="19"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="7">
        <location>
            <begin position="55"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAG01563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="491" mass="53870" checksum="450D73C0BE268F04" modified="2016-09-07" version="1" fragment="single">MRVTSALLAGLVASTADALVAKAAIDKCLTDAGVPIDVKGSDGWNEDVAPFNIRLPYLPTAISVPATTKHIQDSVKCGKKLGIKVSAKSGGHSYASFGFGGENGHLVVELDQMYNVTYDAKKNIATVQPGARLGHVATVLYEKYGRAIAHGTCPGVGVSGHFLHGGFGFSSHMHGLALDSVQSVTVVLADGTVKEASASTNADLFWGMKGAGSNFGIVASWKLSTFEAPKTLTKFGVALGWTKDTAVAGLEAVENYAKNIMPREVNFRIGDYSKGKPGIEGLYYGTPAQWKKDFQPLLDTLPKGYNISEPQSLTWIQAVIAYSNYDEVDWIHPSPQENFYSKSLTLKGLNGTSAQAFVDYYFDVANNVVDRFWFFQLDMHGGKNSQITKVGKDATSYPHRDKLYIIQFYDRYENNQTYPASSFGFLDGWVDAVTDTIPRSEWGAYINYADSRLPRAEAERQYYGDHLPRLQSLKAKYDPKELFYYPQSVEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C1X4</accession>
    <name>A0A177C1X4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1209605</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441559">
        <property type="protein sequence ID" value="OAG00737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031102.1">
        <property type="nucleotide sequence ID" value="XM_018182231.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C1X4"/>
    <dbReference type="STRING" id="1460663.A0A177C1X4"/>
    <dbReference type="GeneID" id="28765717"/>
    <dbReference type="InParanoid" id="A0A177C1X4"/>
    <dbReference type="OrthoDB" id="3938628at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053083">
        <property type="entry name" value="TF_kinase-domain_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44305">
        <property type="entry name" value="SI:DKEY-192D15.2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="202"/>
            <end position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG00737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="891" mass="103498" checksum="BD430FDEFB678657" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C1Z7</accession>
    <name>A0A177C1Z7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Maf-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_1058617</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KV441558">
        <property type="protein sequence ID" value="OAG00838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031203.1">
        <property type="nucleotide sequence ID" value="XM_018173564.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C1Z7"/>
    <dbReference type="FunCoup" id="A0A177C1Z7">
        <property type="interactions" value="116"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177C1Z7"/>
    <dbReference type="GeneID" id="28757050"/>
    <dbReference type="InParanoid" id="A0A177C1Z7"/>
    <dbReference type="OrthoDB" id="10267058at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047429">
        <property type="term" value="F:nucleoside triphosphate diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00555">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00528">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029001">
        <property type="entry name" value="ITPase-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003697">
        <property type="entry name" value="Maf-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00172">
        <property type="entry name" value="maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43213">
        <property type="entry name" value="BIFUNCTIONAL DTTP/UTP PYROPHOSPHATASE/METHYLTRANSFERASE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43213:SF5">
        <property type="entry name" value="BIFUNCTIONAL DTTP_UTP PYROPHOSPHATASE_METHYLTRANSFERASE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02545">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52972">
        <property type="entry name" value="ITPase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAG00838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="275" mass="30148" checksum="DF3EF185B8FFB2E4" modified="2016-09-07" version="1" fragment="single">PADPPPSYDELRNMPTPVHASTTPNAAPEPSRSPRRPPGPPPLLPLDVPALTQLRHKRVVLASASPRRKQLLSILGLKYVEIVPSTFKEDLPKSLSPYEYVLETATEKCREVYTREVNNEEKGEPALVIAADTIIISAKGRILEKPRNPQDHLDMLKMLRDEGAHRVSTAVVVMKPLENPIDPGYAMESHVEITSVKFDANVSDATLVAYVRTRDGNDKAGGYGIQSAGSILIEKIEGAHDNVIGLPLRVTLGLIEKVMVPEEGLDDNMDNMFGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C281</accession>
    <name>A0A177C281_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1100804</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441558">
        <property type="protein sequence ID" value="OAG00837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031202.1">
        <property type="nucleotide sequence ID" value="XM_018174882.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C281"/>
    <dbReference type="STRING" id="1460663.A0A177C281"/>
    <dbReference type="GeneID" id="28758368"/>
    <dbReference type="InParanoid" id="A0A177C281"/>
    <dbReference type="OrthoDB" id="809632at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016628">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05288">
        <property type="entry name" value="PGDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000121">
        <property type="entry name" value="Prostaglandin reductase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041694">
        <property type="entry name" value="ADH_N_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045010">
        <property type="entry name" value="MDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43205">
        <property type="entry name" value="PROSTAGLANDIN REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43205:SF7">
        <property type="entry name" value="PROSTAGLANDIN REDUCTASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16884">
        <property type="entry name" value="ADH_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="2">
        <location>
            <begin position="56"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG00837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="354" mass="38926" checksum="6E9DBAABF1D442BF" modified="2016-09-07" version="1">MVQNKGIIFKEIPTGWPEPGKHLAIEARDFDLEQAPPEGGMTVKTYYASFDPYQRGRMRDPSIKSYSAPFQLGKPITNRTIMKVLKSNSDKYQPGDVVISAGVSAIEEYTALSKEEVQQVRKLENPLNLDPKHFLGALGMPGLTAWSSFYEIGQPKKGETIFISAASGAVGQLVGQLAKHEGLKVVGSVGSDDKLEFITKELGFDAGFNYKKEKPSEALKRLAPNGVDIYYENVGGEQLEAAITAMNDFGRIVACGMISQYNLPPGEQYPIRNLMQVVSKRLTMRGFIVSDANMGPKHYQDHQQKLQKWLANGEFKAKLSVTEGIDNGIDGFLGMLKGANFGKAILQLADLTKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2023-06-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C295</accession>
    <name>A0A177C295_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_243251</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441558">
        <property type="protein sequence ID" value="OAG00760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031125.1">
        <property type="nucleotide sequence ID" value="XM_018185649.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C295"/>
    <dbReference type="GeneID" id="28769135"/>
    <dbReference type="InParanoid" id="A0A177C295"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG00760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="71" mass="7962" checksum="15579BCDF5EF4796" modified="2016-09-07" version="1">MAYPAIVCSCHGLATTVARMAGLLEPLSLRIFCELIMLQSRASQVRYRAHLVDLHFAAHHQAYLHATSRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C2E3</accession>
    <name>A0A177C2E3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_275827</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441558">
        <property type="protein sequence ID" value="OAG01032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031397.1">
        <property type="nucleotide sequence ID" value="XM_018185710.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C2E3"/>
    <dbReference type="GeneID" id="28769196"/>
    <dbReference type="InParanoid" id="A0A177C2E3"/>
    <dbReference type="OrthoDB" id="5397557at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="1">
        <location>
            <begin position="180"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG01032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="298" mass="34573" checksum="B0EB999C587BEC81" modified="2016-09-07" version="1">MPYRYQRSNLPAKRWAIACSGRGGCYFLGYVAIQVSRVKKVILNHNGESGRWEDDKEPFAYVLQLLLWSCPPDIKASALYKTKQKSRQPVYATKTPSRLWRRVSFALAADGEWEEREPELSRKTILLPPKLFQGPVGRFQQLLHERCQQLTLRRVGLWPLMVEALDRYHFDQGRNEPFSCPLPACDGYFTKAGAWSVHAAENHCGQWSSLLSILPGQVGVHFEARRRALESNEKRVQEQYEEVQHTWRTASKTTQQEIQRSWMEQLGSDPSWETSKQGEQSDVWRHFINHMTPGWLEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C2R8</accession>
    <name>A0A177C2R8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ARM repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CC84DRAFT_1128361</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441558">
        <property type="protein sequence ID" value="OAG01037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031402.1">
        <property type="nucleotide sequence ID" value="XM_018175796.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C2R8"/>
    <dbReference type="FunCoup" id="A0A177C2R8">
        <property type="interactions" value="999"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177C2R8"/>
    <dbReference type="GeneID" id="28759282"/>
    <dbReference type="InParanoid" id="A0A177C2R8"/>
    <dbReference type="OrthoDB" id="27832at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035145">
        <property type="term" value="C:exon-exon junction complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.180:FF:000052">
        <property type="entry name" value="Nonsense-mediated mRNA decay factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.180:FF:000037">
        <property type="entry name" value="Nonsense-mediated mRNA decay factor (Upf2)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.80.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003890">
        <property type="entry name" value="MIF4G-like_typ-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039762">
        <property type="entry name" value="Nmd2/UPF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007193">
        <property type="entry name" value="Upf2/Nmd2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12839">
        <property type="entry name" value="NONSENSE-MEDIATED MRNA DECAY PROTEIN 2 UP-FRAMESHIFT SUPPRESSOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12839:SF7">
        <property type="entry name" value="REGULATOR OF NONSENSE TRANSCRIPTS 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02854">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04050">
        <property type="entry name" value="Upf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00543">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MIF4G" evidence="4">
        <location>
            <begin position="475"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="domain" description="MIF4G" evidence="4">
        <location>
            <begin position="680"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="243"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="421"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="911"/>
            <end position="1009"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1106"/>
            <end position="1144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="244"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="421"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="921"/>
            <end position="962"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAG01037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="1144" mass="130072" checksum="D7699D5A5F280C50" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C2U5</accession>
    <name>A0A177C2U5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_1179796</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441557">
        <property type="protein sequence ID" value="OAG01765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032130.1">
        <property type="nucleotide sequence ID" value="XM_018180433.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C2U5"/>
    <dbReference type="STRING" id="1460663.A0A177C2U5"/>
    <dbReference type="GeneID" id="28763919"/>
    <dbReference type="InParanoid" id="A0A177C2U5"/>
    <dbReference type="OrthoDB" id="3066029at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000354">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF64">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G11760)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="80"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="115"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="171"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="205"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="236"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="297"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="335"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="376"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="402"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="447"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="470"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="81"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAG01765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="518" mass="56828" checksum="A94ABAF975655C43" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C322</accession>
    <name>A0A177C322_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">TfdA family taurine dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CC84DRAFT_1262146</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TfdA dioxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441556">
        <property type="protein sequence ID" value="OAG02144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032509.1">
        <property type="nucleotide sequence ID" value="XM_018185127.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C322"/>
    <dbReference type="STRING" id="1460663.A0A177C322"/>
    <dbReference type="GeneID" id="28768613"/>
    <dbReference type="InParanoid" id="A0A177C322"/>
    <dbReference type="OrthoDB" id="10257314at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016706">
        <property type="term" value="F:2-oxoglutarate-dependent dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051323">
        <property type="entry name" value="AtsK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT SULFONATE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468:SF10">
        <property type="entry name" value="TAUD_TFDA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="8">
        <location>
            <begin position="45"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAG02144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="373" mass="41641" checksum="210D5942870211B5" modified="2016-09-07" version="1">MPSSTEGTTNGTSNGTGHPSIPGSCPSCPIPLKYSGSLDHLHYFEITPIIGREYPDVKVTDILNAPNAEEQIRDLAIVISERGVVFFRDQDDLKIDDQKKFCDLLGKLSGRPEDHGLHVHPIYRDPGNLTLPDGTTDENIYVINSEAQKKIYKTMARRAPTEPRDLSREWHSDSTFENAPSDFSFLKMEETPPHGGDTLWCSGYEIYDRMSPSFRSYLETLTATCAQPVFKSAAEAGKYEVMSPRGSPLNVGDEFAPSHPVVRTNRITGWKAIFAGVGLHVTKINDVYSYEDQFIREYVMRLITRNHDSIARMKWTKNAAAIWNNSCVWHAATPDTHLVDGNRTGVRASSIGEVPYLDPNSKSRREALGIPII</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C330</accession>
    <name>A0A177C330_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1189696</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441557">
        <property type="protein sequence ID" value="OAG01319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031684.1">
        <property type="nucleotide sequence ID" value="XM_018181070.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C330"/>
    <dbReference type="STRING" id="1460663.A0A177C330"/>
    <dbReference type="GeneID" id="28764556"/>
    <dbReference type="InParanoid" id="A0A177C330"/>
    <dbReference type="OrthoDB" id="410198at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052523">
        <property type="entry name" value="Trichothecene_AcTrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791">
        <property type="entry name" value="GNAT FAMILY ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791:SF5">
        <property type="entry name" value="HYPOTHETICAL ACETYLTRANSFERASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13508">
        <property type="entry name" value="Acetyltransf_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="46"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG01319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="248" mass="28849" checksum="7ADF0AAD77F2A149" modified="2016-09-07" version="1">MAAKYVVREMKSKGEMDAIMDVIWAANYDPYDTYAQLFFPVLGYTASAREAAIAESKDRFWENHNSTPTSNWFYVEDTTNGRVVGCAQWEIHTQNPFKAGAPTLRAPWWPEGEYRDFCEEIIRQVYTPRTHWMRRPHLALNWMAVLPAYRGKDIGSLLMSIGTSRADALGVECWMEASGMGKKLYEKHGFRSLFKMQFDMERKDASDVWRKCMHELTPTPVYPMWRPKHGIWELEGDSIQFPWERGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C384</accession>
    <name>A0A177C384_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_1128757</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441558">
        <property type="protein sequence ID" value="OAG01248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031613.1">
        <property type="nucleotide sequence ID" value="XM_018175809.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C384"/>
    <dbReference type="GeneID" id="28759295"/>
    <dbReference type="InParanoid" id="A0A177C384"/>
    <dbReference type="OrthoDB" id="39175at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF17">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="32"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAG01248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="577" mass="64858" checksum="9B57FC2DF415A004" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C3J1</accession>
    <name>A0A177C3J1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Conidial pigment biosynthesis 1,3,6,8-tetrahydroxynaphthalene reductase Arp2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CC84DRAFT_1189716</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441557">
        <property type="protein sequence ID" value="OAG01347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031712.1">
        <property type="nucleotide sequence ID" value="XM_018181073.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C3J1"/>
    <dbReference type="STRING" id="1460663.A0A177C3J1"/>
    <dbReference type="GeneID" id="28764559"/>
    <dbReference type="InParanoid" id="A0A177C3J1"/>
    <dbReference type="OrthoDB" id="47007at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43639">
        <property type="entry name" value="OXIDOREDUCTASE, SHORT-CHAIN DEHYDROGENASE/REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_5G02870)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43639:SF1">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoreductase" evidence="4">
        <location>
            <begin position="14"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAG01347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="256" mass="27398" checksum="78C61E84673FABA9" modified="2016-09-07" version="1">MALSAAPPKTLEGKVALVTGSGRGIGAGVARELGARGASVVVNYRGSAEAAEALSREIEAAGSKSIAIQGDIANVEDIKTLFEKTKAHFGKIDIVVSNSGIEHFGKLDEVTPEEFDKVFAVNTRGQFFVAQQAYKHLEDGGRLVLMSSISAHNSIKEHALYAGSKNAVEAFAKNFAKDFGPRRITVNTIAPGGVKTDMANDVGWKYLPNADETWTWEQVEAVVSKWTPLGRIGLPQDIGRVVAFLVGPDGYWINGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C542</accession>
    <name>A0A177C542_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">LysM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CC84DRAFT_1208151</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441556">
        <property type="protein sequence ID" value="OAG02012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032377.1">
        <property type="nucleotide sequence ID" value="XM_018182148.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C542"/>
    <dbReference type="STRING" id="1460663.A0A177C542"/>
    <dbReference type="GeneID" id="28765634"/>
    <dbReference type="InParanoid" id="A0A177C542"/>
    <dbReference type="OrthoDB" id="2281372at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052210">
        <property type="entry name" value="LysM1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34997">
        <property type="entry name" value="AM15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34997:SF1">
        <property type="entry name" value="PEPTIDOGLYCAN-BINDING LYSIN DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0843">Virulence</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008057825" description="LysM domain-containing protein" evidence="3">
        <location>
            <begin position="22"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="4">
        <location>
            <begin position="61"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAG02012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="199" mass="21679" checksum="77DCF202BC8C6196" modified="2016-09-07" version="1">MFNILSITNIALLALVPAVTASPLQSTTLQPRQATLPPTCSDFYSPDSGHVCIIRPTNCVANYTVTPGENCGTVVSRFANFTATDLYAWNPEIRQDCTGLRAYVPVCIGVPGYTFNGPYVGGNRLTAGRTPVPIQPGIVDNCGAFQYTDSKGQKPFAELLSTNHITQQQWNAWNWPKSNVDDNLAVFAGYWSCIALKQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C5M1</accession>
    <name>A0A177C5M1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">DNase I-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CC84DRAFT_1167305</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="6">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="6">Probably binds two magnesium or manganese ions per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA repair enzymes AP/ExoA family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441556">
        <property type="protein sequence ID" value="OAG02182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032547.1">
        <property type="nucleotide sequence ID" value="XM_018179149.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C5M1"/>
    <dbReference type="STRING" id="1460663.A0A177C5M1"/>
    <dbReference type="GeneID" id="28762635"/>
    <dbReference type="InParanoid" id="A0A177C5M1"/>
    <dbReference type="OrthoDB" id="498125at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003906">
        <property type="term" value="F:DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008311">
        <property type="term" value="F:double-stranded DNA 3'-5' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004808">
        <property type="entry name" value="AP_endonuc_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22748">
        <property type="entry name" value="AP ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22748:SF14">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51435">
        <property type="entry name" value="AP_NUCLEASE_F1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0464">Manganese</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="8">
        <location>
            <begin position="43"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="199"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="5">
        <location>
            <position position="250"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="360"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="250"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="252"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="359"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="360"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="7">
        <location>
            <position position="252"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="7">
        <location>
            <position position="329"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA substrate" evidence="7">
        <location>
            <position position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR604808-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR604808-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR604808-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAG02182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="393" mass="43561" checksum="D89AE2433A3C8EC6" modified="2016-09-07" version="1">MNCEISPPPAKRRKTSTNNVTPIKASISLPPTVPDADTMRIFSWNINGITPFLQKPITTYFNPTKPTSNANIPPASLRGFLKRHHWPAILFLQEVKIAAKDLKTQDAVQTAVNASLPAETSELGPGPRYEAHFTLPRDPHNARGSRGTGKVYGVCSIVRADVAKKLAATVRTVDWDTEGRVSVVELHSPSTKLALFNIYAINGTDAPYRDPATGVLRGTRHERKLAFHRFLMEECLEMEQDGWDVFLAGDMNVAPAAIDGFPRLRTFPHQHVVNRADFNARFLDTSKKKQGEGKVFEGIDVWRRMNEGVKRYTWFPRGRQWGSSCDRVDYIVVGESIWDRGMVRGAGILDSEAERGPSDHVPIWADIGLSGVDEEGNGKGAVLDGMRSYDLGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C675</accession>
    <name>A0A177C675_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">EthD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1008204</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441556">
        <property type="protein sequence ID" value="OAG02278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032643.1">
        <property type="nucleotide sequence ID" value="XM_018173348.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C675"/>
    <dbReference type="GeneID" id="28756834"/>
    <dbReference type="InParanoid" id="A0A177C675"/>
    <dbReference type="OrthoDB" id="3729777at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG02278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="249" mass="28716" checksum="586DF1660F3FF1AE" modified="2016-09-07" version="1">MSKILGIWGEVPEENQEWLENTQIPEAAKRLGTRALYFQAGENMFPEENAQTATSFTLYDPLESADSQLSPEQGLSPANSSIDALKDVILEAQYHTCQYEDKAKSFSGDLADVGCLVMGSFQPTPEMHDAFFEWWRGEFVPFIQRSPDFLRVRLWKLEAAADLRNQMVQKRTPDDLYPYIMVYEFKSYDMPWEVAVEIGQSKAYQQFVEKDLKYRYGVYHLKRIYKATGEVEAEFNKDAYSDDEEQGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C6H0</accession>
    <name>A0A177C6H0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Taurine dioxygenase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CC84DRAFT_1251412</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TfdA dioxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG03233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033598.1">
        <property type="nucleotide sequence ID" value="XM_018184328.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C6H0"/>
    <dbReference type="STRING" id="1460663.A0A177C6H0"/>
    <dbReference type="GeneID" id="28767814"/>
    <dbReference type="InParanoid" id="A0A177C6H0"/>
    <dbReference type="OrthoDB" id="10257314at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016706">
        <property type="term" value="F:2-oxoglutarate-dependent dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051323">
        <property type="entry name" value="AtsK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT SULFONATE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468:SF10">
        <property type="entry name" value="TAUD_TFDA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="8">
        <location>
            <begin position="77"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="355"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAG03233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="396" mass="44112" checksum="FC4F914F511E972F" modified="2016-09-07" version="1">MAPGILEENASKQAPIDNAHASEPLKPSGVLDKFDYEEVTPIIGREFPQLNIVDDLINAENSDELLRELAITSMCKVSRRGVVFFRSQDNLTNDLQKQLVDRLGKLTQKPSGSTLHIHPVLNNTSEFGVNDAEISTISSKARKQIFKHDRQADRRRYDAAQWHSDIQFEPVPADYTSLRLVELPRDERGIPTGGDTLWASGYEIYDRFSAPYRKFLESLTATFSGEGFTRAAAANPDKVKIHEGPRGSPSNVGKELSAVHPVVRTNPVTGWKSVFALGPFPKQINELHSDESEELLKKLLSVIPNSHDLQVRLKWKNENDLAIWDNRSVFHTATFDYESLGERFGNRAVGIGERPFLDPNSKSRSEALAEEAGAKATLPTRKAEGEQKEQVLTGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C6U0</accession>
    <name>A0A177C6U0_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 19">Serine/threonine-protein kinase RIO1</fullName>
            <ecNumber evidence="4 19">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">CC84DRAFT_1022366</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25 26">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="27">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 22">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 19">Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4 19"/>
    <dbReference type="EMBL" id="KV441556">
        <property type="protein sequence ID" value="OAG02457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032822.1">
        <property type="nucleotide sequence ID" value="XM_018173387.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C6U0"/>
    <dbReference type="FunCoup" id="A0A177C6U0">
        <property type="interactions" value="941"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177C6U0"/>
    <dbReference type="GeneID" id="28756873"/>
    <dbReference type="InParanoid" id="A0A177C6U0"/>
    <dbReference type="OrthoDB" id="205248at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05147">
        <property type="entry name" value="RIO1_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000232">
        <property type="entry name" value="Serine/threonine-protein kinase RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000148">
        <property type="entry name" value="Serine/threonine-protein kinase RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051272">
        <property type="entry name" value="RIO-type_Ser/Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018934">
        <property type="entry name" value="RIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000687">
        <property type="entry name" value="RIO_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018935">
        <property type="entry name" value="RIO_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017407">
        <property type="entry name" value="Ser/Thr_kinase_Rio1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45723">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01163">
        <property type="entry name" value="RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038147">
        <property type="entry name" value="Ser/Thr_PK_RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00090">
        <property type="entry name" value="RIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01245">
        <property type="entry name" value="RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14 19 21" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12 19" id="KW-0418">Kinase</keyword>
    <keyword evidence="15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 19 21" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="8 19" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="9 19" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RIO kinase" evidence="24">
        <location>
            <begin position="91"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="75"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="421"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="23">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="23">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="23">
        <location>
            <begin position="43"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="23">
        <location>
            <begin position="87"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="23">
        <location>
            <begin position="421"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="23">
        <location>
            <begin position="450"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="23">
        <location>
            <begin position="480"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="20">
        <location>
            <position position="277"/>
        </location>
    </feature>
    <feature type="active site" description="4-aspartylphosphate intermediate" evidence="20">
        <location>
            <position position="294"/>
        </location>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="225"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="282"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="294"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRNR" id="PIRNR038147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRSR" id="PIRSR038147-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PIRSR" id="PIRSR038147-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PIRSR" id="PIRSR038147-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="SMART" id="SM00090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="OAG02457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="502" mass="57547" checksum="1381F3FA9055492D" modified="2016-09-07" version="1">MASTESTVPTTNEPIVGEEGESDIEDLFYPSDDDEVPELVAGPNTQKQSKPSANTSASLDDQVALLSKHASRIRLDNRMAGMGGGPSRDKDKADRATSEQVLDPRTRMILLQLLNRNIVSEINGVISTGKEANVYHAATIPEDDAQPLHRAIKVYKTSILVFKDRDKYVTGEFRFRTGYNKSNNRAMVKVWAEKEMRNLRRIYNAGIPAPEPLYLRLHVLVMSFLGDKKGWPAPRLRDVKFEGLTAEEEEQKWTSIYIQLLGYMRTMYQTCRLVHADLSEYNLLYHENTLYMIDVSQSVEHDHPRSLEFLRMDVKNVSDFFRTRNVNVLSERKVFIFVTGEEGGKEPADMEKYVREMFEKKDAMNEEDQLREDNDEEVFRQQYIPQTLDQVYDIERDAELVNSGQGNELIYQGLLAGKATDGTTVSQNESDASHEGSDSEGTSDEDDESRFEKGTPRGKRNMDKDVKREHKKAVKEEKREKRKEKMPKHVKKKMVSQSSRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C719</accession>
    <name>A0A177C719_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_970299</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the AB hydrolase superfamily. Epoxide hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG03335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033700.1">
        <property type="nucleotide sequence ID" value="XM_018188008.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C719"/>
    <dbReference type="STRING" id="1460663.A0A177C719"/>
    <dbReference type="GeneID" id="28771494"/>
    <dbReference type="InParanoid" id="A0A177C719"/>
    <dbReference type="OrthoDB" id="408373at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43329">
        <property type="entry name" value="EPOXIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="50"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAG03335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="393" mass="44468" checksum="FE0480654EA324B6" modified="2016-09-07" version="1">MPQAAHSPARNPLPPLPLPDGVTEHYLQCPSNGLTFHLLEAGYSPEKQKPLVILVHGYPELAFSWRKVLPALANAGYYVVAFDQRGYGRTTGWDNSPFPKVNMAEFTVTNLVRDVVVLVHALGYRAVKCIVGHDFGAVTSSMCAWMRPDLFHSVVMMSHPFKEHPGLPFDLLHGEPSTPPPQVDIQKELAKLPEPRKHYKWYNATSTAALHWYSPNQGLAAFLRGYWHVKSADWDGNDPQPLEAWSAPELAKMPFYYIMPFAKSMPETIELMMRGEDAEKSKRWLSDEALEVYVQEWRRTGFQGGLNWYRTMADPENKRDMDLFAGRKIECPSIFISGAKDWGNYQEPGALQGFPKTCSQFKGVRIIEGAGHWPQQEQPEAVVKEILGFLENL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C736</accession>
    <name>A0A177C736_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Serine hydroxymethyltransferase</fullName>
            <ecNumber evidence="13">2.1.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CC84DRAFT_1149078</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 13">Interconversion of serine and glycine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine</text>
            <dbReference type="Rhea" id="RHEA:15481"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="EC" id="2.1.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 12 13">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5 13">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 13">Belongs to the SHMT family.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.1" evidence="13"/>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG03564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033929.1">
        <property type="nucleotide sequence ID" value="XM_018176656.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C736"/>
    <dbReference type="FunCoup" id="A0A177C736">
        <property type="interactions" value="445"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177C736"/>
    <dbReference type="GeneID" id="28760142"/>
    <dbReference type="InParanoid" id="A0A177C736"/>
    <dbReference type="OrthoDB" id="10265628at2759"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004372">
        <property type="term" value="F:glycine hydroxymethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019264">
        <property type="term" value="P:glycine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00378">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000097">
        <property type="entry name" value="Serine hydroxymethyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00051">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001085">
        <property type="entry name" value="Ser_HO-MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049943">
        <property type="entry name" value="Ser_HO-MeTrfase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019798">
        <property type="entry name" value="Ser_HO-MeTrfase_PLP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039429">
        <property type="entry name" value="SHMT-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000586">
        <property type="entry name" value="PRK00011.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11680">
        <property type="entry name" value="SERINE HYDROXYMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11680:SF57">
        <property type="entry name" value="SERINE HYDROXYMETHYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00464">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000412">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00096">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7 13" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="9 12 13" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Serine hydroxymethyltransferase-like" evidence="14">
        <location>
            <begin position="53"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="12">
        <location>
            <position position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00006376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000412-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OAG03564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="524" mass="57953" checksum="7A96243891497BC7" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C7U6</accession>
    <name>A0A177C7U6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1165706</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG03476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033841.1">
        <property type="nucleotide sequence ID" value="XM_018178780.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C7U6"/>
    <dbReference type="STRING" id="1460663.A0A177C7U6"/>
    <dbReference type="GeneID" id="28762266"/>
    <dbReference type="InParanoid" id="A0A177C7U6"/>
    <dbReference type="OrthoDB" id="5407653at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="436"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="254"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="442"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG03476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="607" mass="67199" checksum="E1027BBCF9478CAD" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C824</accession>
    <name>A0A177C824_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="7">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CC84DRAFT_1166049</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the peptidase C12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="7"/>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG03894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034259.1">
        <property type="nucleotide sequence ID" value="XM_018178862.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C824"/>
    <dbReference type="FunCoup" id="A0A177C824">
        <property type="interactions" value="549"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177C824"/>
    <dbReference type="GeneID" id="28762348"/>
    <dbReference type="InParanoid" id="A0A177C824"/>
    <dbReference type="OrthoDB" id="427186at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09616">
        <property type="entry name" value="Peptidase_C12_UCH_L1_L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.532.10:FF:000008">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.532.10">
        <property type="entry name" value="Peptidase C12, ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001578">
        <property type="entry name" value="Peptidase_C12_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036959">
        <property type="entry name" value="Peptidase_C12_UCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10589">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10589:SF41">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01088">
        <property type="entry name" value="Peptidase_C12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00707">
        <property type="entry name" value="UBCTHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52048">
        <property type="entry name" value="UCH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="3 7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UCH catalytic" evidence="8">
        <location>
            <begin position="4"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS52048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAG03894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="242" mass="26372" checksum="B2AF46D3CD00DB70" modified="2016-09-07" version="1">MAERFEMLENNPQVMNHLAYALGLDKSLSFYDIYSLDDPDLLAFIPRPALALLVIIPLTPSWHAARTAEDKDTPDYAGKGEEEPVIWFKQLETIGHACGSIGLTHAVLNSDATKRVRPGSTLDQIRKDALPKTMIDRAKVLENSDAFAKAHGDAVKLGDTAAPAFEVENGQHFVTFVKGKDGHLWELEGSRKGPLDRGALKEDEDVLSPAALEKGLGRLIKIEAESGGDLRFSAIALAESLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C856</accession>
    <name>A0A177C856_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 10">Inositol-pentakisphosphate 2-kinase</fullName>
            <ecNumber evidence="4 10">2.7.1.158</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CC84DRAFT_1166720</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Has kinase activity and phosphorylates inositol-1,3,4,5,6-pentakisphosphate (Ins(1,3,4,5,6)P5) to produce 1,2,3,4,5,6-hexakisphosphate (InsP6), also known as phytate.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ATP = 1D-myo-inositol hexakisphosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20313"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57733"/>
            <dbReference type="ChEBI" id="CHEBI:58130"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.158"/>
        </reaction>
    </comment>
    <comment type="domain">
        <text evidence="10">The EXKPK motif is conserved in inositol-pentakisphosphate 2-kinases of both family 1 and 2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the IPK1 type 1 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.158" evidence="4 10"/>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG02937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033302.1">
        <property type="nucleotide sequence ID" value="XM_018179034.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C856"/>
    <dbReference type="STRING" id="1460663.A0A177C856"/>
    <dbReference type="GeneID" id="28762520"/>
    <dbReference type="InParanoid" id="A0A177C856"/>
    <dbReference type="OrthoDB" id="272370at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035299">
        <property type="term" value="F:inositol-1,3,4,5,6-pentakisphosphate 2-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032958">
        <property type="term" value="P:inositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.110">
        <property type="entry name" value="Inositol-pentakisphosphate 2-kinase, N-lobe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009286">
        <property type="entry name" value="Ins_P5_2-kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043001">
        <property type="entry name" value="IP5_2-K_N_lobe"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14456">
        <property type="entry name" value="INOSITOL POLYPHOSPHATE KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14456:SF2">
        <property type="entry name" value="INOSITOL-PENTAKISPHOSPHATE 2-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06090">
        <property type="entry name" value="Ins_P5_2-kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OAG02937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="433" mass="48865" checksum="291DF71232B77C7D" modified="2016-09-07" version="1">MDFEGPRPSLSEEENSDAKSEAAQESHAASPVSYEPKIRCRLTRDQITSESSNSVRFEFLAEGAANTVFRVVPYSLQDGKESFVFEDDQGNILAKEKLAKNVLRMSKGKPKTLKYKEIMEGFETVVKPLFRKTEPSEEGASSRSTAIKLSINESFEEFIMDHEGVAITPEAIKALLAEMHTHCPDNRHIESHHLEERGILLPDMSSVLGSVTTIEIKPKWLLQSPNAPRDAYLCRTCALQASRQSKKAIKKTWICPLALVAGNKAAIEPYIRHRSLSTMAEKPGHHVLHRPSRDEEALNQHLEDEVEAVVQRAVPYLTTGPGHHILQHIRYLQGQLDPAGVLSCPLSSTEEDRLRLAMTLRDCSLFIRIPWADPNAPIEAKLGDLDFKSRGKKQDWSMKEEGLLHGGWYVDLESRMDECWIAQGWKKYAPHYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C8L9</accession>
    <name>A0A177C8L9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Peptide hydrolase</fullName>
            <ecNumber evidence="11">3.4.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CC84DRAFT_1197528</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the peptidase M28 family. M28E subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="11"/>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG03983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034348.1">
        <property type="nucleotide sequence ID" value="XM_018181526.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C8L9"/>
    <dbReference type="FunCoup" id="A0A177C8L9">
        <property type="interactions" value="24"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177C8L9"/>
    <dbReference type="GeneID" id="28765012"/>
    <dbReference type="InParanoid" id="A0A177C8L9"/>
    <dbReference type="OrthoDB" id="2214at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008235">
        <property type="term" value="F:metalloexopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03879">
        <property type="entry name" value="M28_AAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000042">
        <property type="entry name" value="Peptide hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045175">
        <property type="entry name" value="M28_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147:SF56">
        <property type="entry name" value="AMINOPEPTIDASE YDR415C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147">
        <property type="entry name" value="METALLOPEPTIDASE M28 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 13" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 11" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0732">Signal</keyword>
    <keyword evidence="8 11" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007948947" description="Peptide hydrolase" evidence="11">
        <location>
            <begin position="18"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M28" evidence="12">
        <location>
            <begin position="170"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00043962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OAG03983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="388" mass="42746" checksum="01F7A6DB59493F1C" modified="2016-09-07" version="1">MKSSLLLPLCTAALVAAVYPPQVVLGDSQQAPIVEADKYLIELAPGETQWVTEDDKWALRRKGINFMDITDNSELGALNSNYGARSVKFPKKIAQNDTVAPLLKQLEKNNMRKHLEVFTSFHTRYYKSQYGAQSSAWLLKQVNDTIAKSGAFEHGASVKAFSHPWGQSSIIATIPGKSNKTVVIGAHQDSINLFLPSILAAPGADDDGSGTVTILEALRVLLKSKDIVKGDFPNTVEFHWYSAEEGGLLGSQAIFQSYEKEGRDVKAMLQQDMTGYVQKTIDAGEPESVGVITDFVDPGLTEFIKEVITEYCNIPYVLTKCGYACSDHASASKAGYPSAFVIESDFKYSDNKIHTTEDKIEYLSFDHMLQHAKLTLALAYELATHKFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C8M9</accession>
    <name>A0A177C8M9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Arf GTPase activating protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_1197605</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG04104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034469.1">
        <property type="nucleotide sequence ID" value="XM_018181531.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C8M9"/>
    <dbReference type="FunCoup" id="A0A177C8M9">
        <property type="interactions" value="720"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177C8M9"/>
    <dbReference type="GeneID" id="28765017"/>
    <dbReference type="InParanoid" id="A0A177C8M9"/>
    <dbReference type="OrthoDB" id="983479at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048205">
        <property type="term" value="P:COPI coating of Golgi vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08831">
        <property type="entry name" value="ArfGap_ArfGap2_3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.150:FF:000013">
        <property type="entry name" value="Putative Arf GTPase-activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45686:SF4">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR GTPASE ACTIVATING PROTEIN 3, ISOFORM H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45686">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR GTPASE ACTIVATING PROTEIN 3, ISOFORM H-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00405">
        <property type="entry name" value="REVINTRACTNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50115">
        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Arf-GAP" evidence="7">
        <location>
            <begin position="10"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="136"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="341"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="255"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAG04104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="471" mass="49926" checksum="AD76683704405531" modified="2016-09-07" version="1">MALATKDQSRNIFAKLKIKPANKVCFDCGAKNPTWSSVPFGIYLCLDCSANHRNMGVHISFVRSTNLDIWQWDQLRIMKVGGNESATKYFQTHGGSAALASKDPKTKYTSNAATKYKEELQRRCVVDARQYPEEVVITDVPEATGSEGTTPAGEDDDFFSSWDKPAVKRPSNPPSRTGTPRAQSPFLKPGATGNGTDRPKSPLAGGSASTPPVARPAVKKATSGVAPKKNILGAKKKGLGAKKVVASDGLDFEEAERKAREEAERIEKLGYDPDAEAAETSATTKPKAPEASNIVAPTPLSPSRGGFGTTSKPEKSSKDVERLGMGVARLGFGQVGAAKSAAAPKKMGGFGSTSKPVADDSETYAREKFGTQKGIGSDEFFGRGSFDPSAAAEAKSRLTGFEGATAISSNAYFGRPEDDVPEDDYGDLEGAAKDFVRKFGITASDDLENLTSLLGEGASKLQGAVRNYLNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C9D2</accession>
    <name>A0A177C9D2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1259764</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG04354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034719.1">
        <property type="nucleotide sequence ID" value="XM_018184938.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C9D2"/>
    <dbReference type="STRING" id="1460663.A0A177C9D2"/>
    <dbReference type="GeneID" id="28768424"/>
    <dbReference type="InParanoid" id="A0A177C9D2"/>
    <dbReference type="OrthoDB" id="3691081at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008057893" evidence="1">
        <location>
            <begin position="21"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG04354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="470" mass="52181" checksum="66FC903C4AD65464" modified="2016-09-07" version="1">MATLSSVLTVALLALGGVDAKRKDKVSYSRYLARDCNGHPLSGDIDDLQLKGGASGCKQIEGQGVRFHMHKKDKYNKWIDDVNRGLWECGATVYRGVDCVLEDIIDQVSLPQAFNECNPLHADAGSISFWCRPNYGYQGIAQPREMELPVTSYSIDKYGKAHPSMYTTVINATQHIYNPLPEFTGITPLVTVTATKILEISTKVNTVPQVETTTTVAVPKVNARAEPAPKVALEPRGKQYNVKGVWMRHPWGQSAICFKCWTRKEMDFGKFKCRSGNYDKYDVPCPPVPNTIAPTTTVDITHTRTVEFWRTEADHFSFATQPSVAAEKRSPHKAVVFHNPYFPDLKVCADAEWENSGKPKAEVRLQKIKSFDKCAKKDPMYIDIGIPEQTRIGHTYVTSSITHTTRPVYAGTNTVTTTKTIIQTHHPSITFTATITQPVSPSTKVVLAPGSTTTATIVQPLFSFPYHPSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C9R7</accession>
    <name>A0A177C9R7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_1096483</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG03861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034226.1">
        <property type="nucleotide sequence ID" value="XM_018174671.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C9R7"/>
    <dbReference type="STRING" id="1460663.A0A177C9R7"/>
    <dbReference type="GeneID" id="28758157"/>
    <dbReference type="InParanoid" id="A0A177C9R7"/>
    <dbReference type="OrthoDB" id="40579at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47660:SF2">
        <property type="entry name" value="TRANSCRIPTION FACTOR WITH C2H2 AND ZN(2)-CYS(6) DNA BINDING DOMAIN (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47660">
        <property type="entry name" value="TRANSCRIPTION FACTOR WITH C2H2 AND ZN(2)-CYS(6) DNA BINDING DOMAIN (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="25"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="53"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAG03861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="142" mass="16567" checksum="71B26A8BBA256369" modified="2016-09-07" version="1">MSAVSTAHRRRRRTIDLRDPSQTSFECQVCNRQYDRADHLERHLDSHRNVRPFRCENCPAAFNRRDLLLRHQTNHEKNAAKGQIGHYIADRAVKACDACVLSKVKCENSRPCQRCVKKVNKHRIQLAEGNHCLLGYFIQYPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CA16</accession>
    <name>A0A177CA16_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribosomal protein L1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_1120836</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG04425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034790.1">
        <property type="nucleotide sequence ID" value="XM_018175593.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CA16"/>
    <dbReference type="FunCoup" id="A0A177CA16">
        <property type="interactions" value="251"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CA16"/>
    <dbReference type="GeneID" id="28759079"/>
    <dbReference type="InParanoid" id="A0A177CA16"/>
    <dbReference type="OrthoDB" id="1747252at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00403">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.790:FF:000001">
        <property type="entry name" value="50S ribosomal protein L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023674">
        <property type="entry name" value="Ribosomal_uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028364">
        <property type="entry name" value="Ribosomal_uL1/biogenesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016095">
        <property type="entry name" value="Ribosomal_uL1_3-a/b-sand"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36427">
        <property type="entry name" value="54S RIBOSOMAL PROTEIN L1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36427:SF3">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL1M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00687">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56808">
        <property type="entry name" value="Ribosomal protein L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAG04425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="294" mass="31951" checksum="856D473249142FEF" modified="2016-09-07" version="1">MAHPRSFLAPLSRITAPSIASARPTLTQLAALPLHQTSIRCKTTKAPDAKKRKARKHYLQSDLKKADQFSLIDAMHYIRAFEVGRTPTSSKYEVHVRFRTLKNGPSVRNRLRLPHPVKTDLRICVIAPPGSKAAADARAAGASLVGEDEVFAQIKEGNIDFDRCICHMDSLQKMNKAALGRILGPKGLMPSTKTGTVVTNVGATVKSMVGASEYRERDAVVRLAVGQLGFTPEEMQTNIKAFMETLKKDIARLNGTPKEIHEVVLSSTNSPGFTLNGDFKGPDSVSARALSGPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CA92</accession>
    <name>A0A177CA92_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CC84DRAFT_1092951</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG04495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034860.1">
        <property type="nucleotide sequence ID" value="XM_018174493.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CA92"/>
    <dbReference type="STRING" id="1460663.A0A177CA92"/>
    <dbReference type="ESTHER" id="9pleo-a0a177ca92">
        <property type="family name" value="Fungal_carboxylesterase_lipase"/>
    </dbReference>
    <dbReference type="GeneID" id="28757979"/>
    <dbReference type="InParanoid" id="A0A177CA92"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="54"/>
            <end position="554"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAG04495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="585" mass="65469" checksum="19DFA99BDC056E98" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CB32</accession>
    <name>A0A177CB32_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Kinase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_1123774</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG04072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034437.1">
        <property type="nucleotide sequence ID" value="XM_018175663.1"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CB32"/>
    <dbReference type="GeneID" id="28759149"/>
    <dbReference type="InParanoid" id="A0A177CB32"/>
    <dbReference type="OrthoDB" id="10267235at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05157">
        <property type="entry name" value="ETNK_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007521">
        <property type="entry name" value="Choline_kin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004776">
        <property type="entry name" value="Mem_transp_PIN-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31794">
        <property type="entry name" value="AUXIN EFFLUX TRANSPORTER FAMILY PROTEIN (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31794:SF2">
        <property type="entry name" value="AUXIN EFFLUX TRANSPORTER FAMILY PROTEIN (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04428">
        <property type="entry name" value="Choline_kin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01633">
        <property type="entry name" value="Choline_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03547">
        <property type="entry name" value="Mem_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="53"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="122"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="154"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="396"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="434"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="476"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="domain" description="Choline kinase N-terminal" evidence="7">
        <location>
            <begin position="792"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="237"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="271"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="565"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="643"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="691"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="888"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1170"/>
            <end position="1197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1273"/>
            <end position="1343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="249"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="271"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="285"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="650"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="692"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="706"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="721"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1170"/>
            <end position="1179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1292"/>
            <end position="1322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAG04072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="1384" mass="153433" checksum="57C7A99477E309D7" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CC58</accession>
    <name>A0A177CC58_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1164809</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG04300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034665.1">
        <property type="nucleotide sequence ID" value="XM_018178567.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CC58"/>
    <dbReference type="FunCoup" id="A0A177CC58">
        <property type="interactions" value="655"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CC58"/>
    <dbReference type="GeneID" id="28762053"/>
    <dbReference type="InParanoid" id="A0A177CC58"/>
    <dbReference type="OrthoDB" id="10249920at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047631">
        <property type="term" value="F:ADP-ribose diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006753">
        <property type="term" value="P:nucleoside phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019693">
        <property type="term" value="P:ribose phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd18888">
        <property type="entry name" value="NUDIX_ADPRase_Nudt5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000016">
        <property type="entry name" value="ADP-sugar pyrophosphatase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11839:SF1">
        <property type="entry name" value="ADP-SUGAR PYROPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11839">
        <property type="entry name" value="UDP/ADP-SUGAR PYROPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="2">
        <location>
            <begin position="52"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG04300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="213" mass="23705" checksum="02DCA6FCB701FB0F" modified="2016-09-07" version="1">MATTKQSKVVKVEPLDHKDAKWATLVKITYTDPEGVERTWESGERLTRPEGADIDGVGILAVLQDPSKPDDSPRILLQKQWRPPVDAIVIEVPAGLIDPNETAEVCAVRELKEETGYVGKVMGGDFGVSPIMCNDPGFCNTNLRMIHVTVDLSLPENQNPQPSLEDNEFIETFSVPLRDLWDECKKFEKEGYAIDARVGTLAEGVECAKRWKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CCR8</accession>
    <name>A0A177CCR8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1216783</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG05435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035800.1">
        <property type="nucleotide sequence ID" value="XM_018182838.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CCR8"/>
    <dbReference type="GeneID" id="28766324"/>
    <dbReference type="InParanoid" id="A0A177CCR8"/>
    <dbReference type="OrthoDB" id="3800557at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG05435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="493" mass="55451" checksum="6B2648015347BF1E" modified="2016-09-07" version="1">MDSSPLSLPVFVRAITPTPSIARTIRPTPAYARTVTPAPASVPTAVPAPDVDFDVDHLPQHTRPSRIKVKELPDTERQRAETTASHLFTNFDDARIRTALVHIIQVRDESHIRPKRGDRTGWAVLQVEKRQQRETMPTERRADADILSRPPPRLAVSAPVILKDSLVWPVPGSPMGNAWSGEHFWKPEFCESVPASPMWEEGGCAHSDAARQSYYDSVVADVEKCALEVKADTMQGDEQMSGAECDVIAAMTVLEEMKAGFGEDDWPVPGDVLAKTKEFCQEEKKALELSPIRDLADMQESYNWLSFEQSSLQPLTKLDEVRGRLKMIKETKRNSGIEPSERVYHLVYAVQILEEKIRTLKLHDIYADNSDDDMMEYGNFLKSLAEVLPLAEECGSSIASYSSDSELEERRDLKREMSEIGLEKMKAVRMDVLSNGLAKRRDLRKEVSEGGLERRRLRGKAPSTLDLESWASSLKVLDNKKKADGFRDEGLFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CCU2</accession>
    <name>A0A177CCU2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1259903</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG04530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034895.1">
        <property type="nucleotide sequence ID" value="XM_018184947.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CCU2"/>
    <dbReference type="GeneID" id="28768433"/>
    <dbReference type="InParanoid" id="A0A177CCU2"/>
    <dbReference type="OrthoDB" id="3796126at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="378"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="459"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="533"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="579"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="612"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="814"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="283"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="309"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="378"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="467"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="555"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="814"/>
            <end position="830"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG04530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="945" mass="102119" checksum="658D87B5D1057020" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CCY6</accession>
    <name>A0A177CCY6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cleavage and polyadenylation specificity factor, 25 kDa subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1121388</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG04742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035107.1">
        <property type="nucleotide sequence ID" value="XM_018175607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CCY6"/>
    <dbReference type="STRING" id="1460663.A0A177CCY6"/>
    <dbReference type="GeneID" id="28759093"/>
    <dbReference type="InParanoid" id="A0A177CCY6"/>
    <dbReference type="OrthoDB" id="277288at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005849">
        <property type="term" value="C:mRNA cleavage factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18871">
        <property type="entry name" value="NUDIX_Cfim25_Nudt21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000005">
        <property type="entry name" value="Cleavage and polyadenylation specificity factor subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016706">
        <property type="entry name" value="Cleav_polyA_spec_factor_su5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13047">
        <property type="entry name" value="PRE-MRNA CLEAVAGE FACTOR IM, 25KD SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13869">
        <property type="entry name" value="NUDIX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="253"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG04742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="273" mass="30822" checksum="0EB3D2DCFD8BB324" modified="2016-09-07" version="1">MSTITKEASQSSYPPILPKDFNGNQPKTIRLYPLSNYTFGTKDAQPEEDPSVLARLKRLEEYYQANGMRRTCEGVLVCHEHNHPHILMLQIANAFFKLPGDYLTHDVEEIEGFKARLNERLAPVGTQFTGEGVNDEWQIGDTLAQWWRPNFETFMYPFIPAHVTRPKECKKLYFIQLPRSKVLSVPKNMKLLAVPLFELYDNTARYGPQLSAIPHLLSRYNFEFVDENGQVVACTPGTGAPDGSRPHVKVLAGGDEDVKMEPNGDAASDHTLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CDK6</accession>
    <name>A0A177CDK6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acyl-CoA N-acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1217047</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG05725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036090.1">
        <property type="nucleotide sequence ID" value="XM_018182859.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CDK6"/>
    <dbReference type="STRING" id="1460663.A0A177CDK6"/>
    <dbReference type="GeneID" id="28766345"/>
    <dbReference type="InParanoid" id="A0A177CDK6"/>
    <dbReference type="OrthoDB" id="410198at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052523">
        <property type="entry name" value="Trichothecene_AcTrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791">
        <property type="entry name" value="GNAT FAMILY ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791:SF14">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG05725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="210" mass="22853" checksum="36C865531B642024" modified="2016-09-07" version="1">MGIKIREASDADIPRAAQGEADAYGAGQNGPSLFFPGPFPVAPTESRANQIINMRNSDPTCQLLIAVDEETGEQMGFAKYHIYKTSEDVSSSAGRPVPSGPGVNEAACEAFFGGLVVRKKAIMGTKPHIYLHMLHTEPKYQRRGAASALLRWGTERADQLGLPVYLESSHEAHILYGRHGFNDAETFECDMRPFGGDKTFTAPLMIRGPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CEI9</accession>
    <name>A0A177CEI9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glycine zipper 2TM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1217320</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG06045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036410.1">
        <property type="nucleotide sequence ID" value="XM_018182880.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CEI9"/>
    <dbReference type="STRING" id="1460663.A0A177CEI9"/>
    <dbReference type="GeneID" id="28766366"/>
    <dbReference type="InParanoid" id="A0A177CEI9"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37014">
        <property type="entry name" value="EXPRESSION LETHALITY PROTEIN HEL10, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G06580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37014:SF10">
        <property type="entry name" value="RICH PROTEIN MS8, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G05650)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="14"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="74"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="102"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="217"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="253"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG06045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="265" mass="27885" checksum="BC480B388FF7C251" modified="2016-09-07" version="1">MSSYDYYGGDGSHNQHPPQQQYGQQGQGHNYPPQQPAYGQQPHDQYSQGQGQYPPQHQQQHSPYPPAQSPYQPPQQGYGAPPQGDYNQGYDQNRGHSPYPPQQQQQHYGAPAQQGYGDQGYGQHQPQQGQYGQHDQYGQGQGQYGAPGGPGGPAEGDRGLGSTLIGGAGGAFLANKMGGGVLGTVGGLVAGAVGANMLSDKKDKKKEKKHKKHGSGSHHSASYAGSAGLGGLYAGSHSGKEHKKHKKHRSKSRGGSSSSSSSDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CEU2</accession>
    <name>A0A177CEU2_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_750889</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG06135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036500.1">
        <property type="nucleotide sequence ID" value="XM_018187294.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CEU2"/>
    <dbReference type="GeneID" id="28770780"/>
    <dbReference type="InParanoid" id="A0A177CEU2"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008058114" description="Secreted protein" evidence="2">
        <location>
            <begin position="18"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG06135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="130" mass="13760" checksum="A718922DE9C32310" modified="2016-09-07" version="1">MYTVLFCSVQFLSMSHHFVCIAYTAVCSEELAEKVNIYPRGTSRAVRTLSKSCTHVPSACETMSGLIQGVGCAGTSGTGRHERSTPPRASFAAASERCLPLPRRVLSRSAPVASGSRSGPACCTQDSAQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CEV3</accession>
    <name>A0A177CEV3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Disintegrin and metalloproteinase domain-containing protein B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CC84DRAFT_1165609</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Probable zinc protease.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG05328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035693.1">
        <property type="nucleotide sequence ID" value="XM_018178758.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CEV3"/>
    <dbReference type="STRING" id="1460663.A0A177CEV3"/>
    <dbReference type="GeneID" id="28762244"/>
    <dbReference type="InParanoid" id="A0A177CEV3"/>
    <dbReference type="OrthoDB" id="5951731at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04271">
        <property type="entry name" value="ZnMc_ADAM_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.70.10:FF:000003">
        <property type="entry name" value="Disintegrin and metalloproteinase domain-containing protein 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.70.10">
        <property type="entry name" value="Disintegrin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001762">
        <property type="entry name" value="Disintegrin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036436">
        <property type="entry name" value="Disintegrin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001590">
        <property type="entry name" value="Peptidase_M12B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034028">
        <property type="entry name" value="ZnMc_ADAM_fungal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11905">
        <property type="entry name" value="ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11905:SF159">
        <property type="entry name" value="ADAM METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00200">
        <property type="entry name" value="Disintegrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13688">
        <property type="entry name" value="Reprolysin_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00050">
        <property type="entry name" value="DISIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57552">
        <property type="entry name" value="Blood coagulation inhibitor (disintegrin)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50215">
        <property type="entry name" value="ADAM_MEPRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50214">
        <property type="entry name" value="DISINTEGRIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008058192" description="Disintegrin and metalloproteinase domain-containing protein B" evidence="7">
        <location>
            <begin position="25"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="698"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M12B" evidence="9">
        <location>
            <begin position="271"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="domain" description="Disintegrin" evidence="8">
        <location>
            <begin position="511"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="742"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="743"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="777"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="424"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="423"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="427"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="433"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00056552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00074021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAG05328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="814" mass="86197" checksum="0A8E5CA8F0A1CB0F" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CF22</accession>
    <name>A0A177CF22_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Mannosyl phosphorylinositol ceramide synthase SUR1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_1144790</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 32 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG05429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035794.1">
        <property type="nucleotide sequence ID" value="XM_018176470.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CF22"/>
    <dbReference type="FunCoup" id="A0A177CF22">
        <property type="interactions" value="38"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CF22"/>
    <dbReference type="GeneID" id="28759956"/>
    <dbReference type="InParanoid" id="A0A177CF22"/>
    <dbReference type="OrthoDB" id="3647at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000030">
        <property type="term" value="F:mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051999">
        <property type="term" value="P:mannosyl-inositol phosphorylceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.20:FF:000001">
        <property type="entry name" value="MIPC synthase subunit (SurA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051706">
        <property type="entry name" value="Glycosyltransferase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007577">
        <property type="entry name" value="GlycoTrfase_DXD_sugar-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32385">
        <property type="entry name" value="MANNOSYL PHOSPHORYLINOSITOL CERAMIDE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32385:SF20">
        <property type="entry name" value="MANNOSYL PHOSPHORYLINOSITOL CERAMIDE SYNTHASE CSH1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04488">
        <property type="entry name" value="Gly_transf_sug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="262"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAG05429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="329" mass="38470" checksum="CC532274BBC2DC1D" modified="2016-09-07" version="1">MRRGILIFLITTIVVLGFAVHHVWTLLELLVIDGREDAILRAELPAPNSGAISERPQLIPKIIHQTYINESIPEHWKGPQQSCIDMHPDYEYKLWTDKKSREFIAAEYPWFLETFDGYPYPIQRADAIRYFVLHHFGGIYIDLDDGCNRSLDPLLAYPAWVRKTTPTGISNDAMGSVPRHKFFLNAIDRLPDYNRRWPLPYITVMASTGPLYLSVIWRHYMKAQPEEADRVRILFPAEYNNHSWSFFTHHLGNSWHNNDVKLIFWMASHWVIITVIGFTLGLALLWCLYSTFVVARQANTHKGKFAYSRIPFYRRISSKDIELNDRHQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CFB9</accession>
    <name>A0A177CFB9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">25S rRNA adenine-N(1) methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CC84DRAFT_724413</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the N(1) position of an adenine present in helix 65 in 25S rRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
            <location evidence="4">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the BMT2 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="4"/>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG05519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035884.1">
        <property type="nucleotide sequence ID" value="XM_018187182.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CFB9"/>
    <dbReference type="FunCoup" id="A0A177CFB9">
        <property type="interactions" value="84"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CFB9"/>
    <dbReference type="GeneID" id="28770668"/>
    <dbReference type="InParanoid" id="A0A177CFB9"/>
    <dbReference type="OrthoDB" id="5954793at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016433">
        <property type="term" value="F:rRNA (adenine) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03044">
        <property type="entry name" value="BMT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021867">
        <property type="entry name" value="Bmt2/SAMTOR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21008:SF1">
        <property type="entry name" value="25S RRNA (ADENINE(2142)-N(1))-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21008">
        <property type="entry name" value="S-ADENOSYLMETHIONINE SENSOR UPSTREAM OF MTORC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11968">
        <property type="entry name" value="Bmt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAG05519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="291" mass="32401" checksum="F4C005DCF75F07F5" modified="2016-09-07" version="1">MAIKKRQKTLSHGRPPISKPKERMTSQRSRTIIRTHHRLHKEHASAVKNGDTKLAASVAKAIEENGGLEVYQAASKQGQSKDRGGDSSKVLVDWLRGANILERPKGKSDGDDGGSVLQCLEVGALSTNNEISKYPKRIEMTRIDLNSQGAGIKKQNFMERPLPTSASERFDIISLSLVLNYVPDPSQRGEMLKRITKFLRHTDTNQKINASVLPALFLVLPLPCVENSRYLDEPLLLRIMTNLGFKLTTEKKTPKLCYYLFSLTGTSNSAKTTKKKVRDGPAMNNFCVIVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CFE7</accession>
    <name>A0A177CFE7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1091770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG06335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036700.1">
        <property type="nucleotide sequence ID" value="XM_018174411.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CFE7"/>
    <dbReference type="GeneID" id="28757897"/>
    <dbReference type="InParanoid" id="A0A177CFE7"/>
    <dbReference type="OrthoDB" id="5405107at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG06335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="161" mass="17925" checksum="5F52799D5C466068" modified="2016-09-07" version="1">MVHWLDVTPEYNTSPLIPLCFVTVLSSYGLYMSYQNITRLQEYEDQAQKLSKWSNTVAARLNKTRTTQTSGTIAMVLSTFCSLLLLLTKFGITTHVVLALICTAVSALARLHMKTFWNEKEQVRIPLMGKFNEAVSGSEEVVQLLGGITAAWIAAGLLSFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CFG4</accession>
    <name>A0A177CFG4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_741623</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG05961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036326.1">
        <property type="nucleotide sequence ID" value="XM_018187260.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CFG4"/>
    <dbReference type="STRING" id="1460663.A0A177CFG4"/>
    <dbReference type="GeneID" id="28770746"/>
    <dbReference type="InParanoid" id="A0A177CFG4"/>
    <dbReference type="OrthoDB" id="2143914at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050560">
        <property type="entry name" value="MYB_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45614">
        <property type="entry name" value="MYB PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45614:SF265">
        <property type="entry name" value="MYB-LIKE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13921">
        <property type="entry name" value="Myb_DNA-bind_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH myb-type" evidence="3">
        <location>
            <begin position="14"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="2">
        <location>
            <begin position="15"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="2">
        <location>
            <begin position="64"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="3">
        <location>
            <begin position="67"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="2">
        <location>
            <begin position="115"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="3">
        <location>
            <begin position="120"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAG05961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="359" mass="40433" checksum="9C65C99B422B5270" modified="2016-09-07" version="1">MLSSSAKSSGRLPRKWTVAEDHKLKEEVEAQMVEGEVKDWCRIAAKLPGRTNKDCRKRWHNSVAGGLKKGQWSKSEDVQLAKGVEQYGQRWTLVANVVGSRSADQCAKRWQQSLDPDLDRSEWRDTDDKVLIDAVQKLGRHWKDIQRHHFQGRSKNCIKNRYTVLVRRYQNQGIILPQPAGTPEPSTYSATDDDDMSYGSTTYDDLLPAHTTQVSTPETQHSWPTDSSYSAWTSQESFDVMTSTAPTYPHVPLTVNVSQGAQWDWATTSMNTSHSPMMALASPHIYPHVSDHATLSPYDHYAASPAMLSPTTAMNYGGHVARGPTSSPISSNASPSYQDPHAMAQFMRYEMRRDPPYQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CGR3</accession>
    <name>A0A177CGR3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CC84DRAFT_1092252</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG06421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036786.1">
        <property type="nucleotide sequence ID" value="XM_018174442.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CGR3"/>
    <dbReference type="FunCoup" id="A0A177CGR3">
        <property type="interactions" value="841"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CGR3"/>
    <dbReference type="GeneID" id="28757928"/>
    <dbReference type="InParanoid" id="A0A177CGR3"/>
    <dbReference type="OrthoDB" id="1875751at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4B/4H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236:SF95">
        <property type="entry name" value="NUCLEOLAR PROTEIN 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="121"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="242"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="208"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="355"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="15"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="34"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="94"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="211"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="365"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="375"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAG06421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="427" mass="47568" checksum="BAF408876E3AEF41" modified="2016-09-07" version="1">MQSASEAEAVILPKKEKRQKKDKKEKKRKAEHVGEEEEQDVREEEDEEQTDKKPSKKRKREILPSEIEIDITAPEPASKKAAREAKRKAKKAKTAPTPSTAADAPTTTETAESKEAKRSAFSVWIGNLPWSATKETLRTFLTENAEIKDDEITRIHMPAPKAPPRPNWTDAKPTNKGFAYVDFATELAMYSAIALTETRMDRRPLLIKNSKNFEGRPDKPKEEQHDGDTTLRGGKEAKAPSKKIFVGNLGFETSKEDLEAHFGQCGAVENIHMATFEDTGKCKGFAWVTFEELDAASAAVKGFVYKKDPDAKKSKANDEDGEGDDKSKKRKFRLNKLLGRDLRCEFAEDGTTRYQKRYGKKPEDGAGGGEGRGFGRPQRGGRPFNPRNNFGERKVDPRTIAPGSAHMNAPRASAAIVKSEGKKTTFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CGX8</accession>
    <name>A0A177CGX8_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1195102</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG06596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036961.1">
        <property type="nucleotide sequence ID" value="XM_018181391.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CGX8"/>
    <dbReference type="STRING" id="1460663.A0A177CGX8"/>
    <dbReference type="GeneID" id="28764877"/>
    <dbReference type="InParanoid" id="A0A177CGX8"/>
    <dbReference type="OrthoDB" id="6077919at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051061">
        <property type="entry name" value="Zinc_finger_trans_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46179:SF19">
        <property type="entry name" value="C2H2 FINGER DOMAIN TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46179">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="455"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="486"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="520"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="365"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="545"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="295"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="365"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="545"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="569"/>
            <end position="578"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG06596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="578" mass="61880" checksum="D7B7DD1B63736D16" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CH10</accession>
    <name>A0A177CH10_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Allantoate permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CC84DRAFT_1088096</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG06855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037220.1">
        <property type="nucleotide sequence ID" value="XM_018174237.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CH10"/>
    <dbReference type="GeneID" id="28757723"/>
    <dbReference type="InParanoid" id="A0A177CH10"/>
    <dbReference type="OrthoDB" id="6730379at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033229">
        <property type="term" value="F:cysteine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000064">
        <property type="entry name" value="MFS allantoate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF63">
        <property type="entry name" value="HIGH AFFINITY CYSTEINE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="71"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="110"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="140"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="171"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="202"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="235"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="304"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="340"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="367"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="399"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="431"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="458"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="71"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAG06855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="525" mass="59747" checksum="7496D4E47C06689C" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CH73</accession>
    <name>A0A177CH73_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1241772</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG06923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037288.1">
        <property type="nucleotide sequence ID" value="XM_018184064.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CH73"/>
    <dbReference type="STRING" id="1460663.A0A177CH73"/>
    <dbReference type="GeneID" id="28767550"/>
    <dbReference type="InParanoid" id="A0A177CH73"/>
    <dbReference type="OrthoDB" id="4708870at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG06923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="346" mass="38119" checksum="B10952C9BE8DF2A6" modified="2016-09-07" version="1">MPGKPHYGDVDFLVSGFLPEPPGTSLNWRRKVASSRDALGTRHVPHPNGEHWIQIDIKWAEDAGLLDQATRLEDQPDGFPHPRRRNGGNQFPGSLVFATKQPTDALRILGLDTRFLLACFAATEETCLDEGKHRGHLEDRSGPWLAFVFEWLPQRIPNIVFLTKKSHFTGGASRRGLPCARKFSRCSQQSLKSTIRSLRIIETIEEHRLQQLLMEAISEGQDGWSDEIPLHTIVVQGAASGTPPLMPVVPAQGDTACASDPPSLMFDASSDLIFSRPVTPPHTPPTCVTDIKPSTPTTASPIEDLRSVLLTPIHTQHLPRDPPLFFVARPPANNMSPAAKLDCLAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CHV7</accession>
    <name>A0A177CHV7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Rap guanine nucleotide exchange factor 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CC84DRAFT_1163337</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG07103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037468.1">
        <property type="nucleotide sequence ID" value="XM_018178244.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CHV7"/>
    <dbReference type="STRING" id="1460663.A0A177CHV7"/>
    <dbReference type="GeneID" id="28761730"/>
    <dbReference type="InParanoid" id="A0A177CHV7"/>
    <dbReference type="OrthoDB" id="28357at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00882">
        <property type="entry name" value="Ras_like_GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06224">
        <property type="entry name" value="REM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.840.10">
        <property type="entry name" value="Ras guanine-nucleotide exchange factors catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.870.10">
        <property type="entry name" value="Son of sevenless (SoS) protein Chain: S domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008937">
        <property type="entry name" value="Ras-like_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000651">
        <property type="entry name" value="Ras-like_Gua-exchang_fac_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023578">
        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001895">
        <property type="entry name" value="RASGEF_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036964">
        <property type="entry name" value="RASGEF_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113:SF348">
        <property type="entry name" value="GUANYL-NUCLEOTIDE EXCHANGE FACTOR RASGEF, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G04700)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00617">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00618">
        <property type="entry name" value="RasGEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00147">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48366">
        <property type="entry name" value="Ras GEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50009">
        <property type="entry name" value="RASGEF_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50212">
        <property type="entry name" value="RASGEF_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-terminal Ras-GEF" evidence="5">
        <location>
            <begin position="436"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GEF" evidence="4">
        <location>
            <begin position="672"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="119"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="344"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="611"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="858"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="7"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="121"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="160"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="348"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="369"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="393"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="410"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="611"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="624"/>
            <end position="636"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAG07103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="960" mass="107460" checksum="4811664E771050B4" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CIH8</accession>
    <name>A0A177CIH8_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ER-bound oxygenase mpaB/mpaB'/Rubber oxygenase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_1258301</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG07116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037481.1">
        <property type="nucleotide sequence ID" value="XM_018184813.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CIH8"/>
    <dbReference type="STRING" id="1460663.A0A177CIH8"/>
    <dbReference type="GeneID" id="28768299"/>
    <dbReference type="InParanoid" id="A0A177CIH8"/>
    <dbReference type="OrthoDB" id="6361347at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037473">
        <property type="entry name" value="Lcp-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018713">
        <property type="entry name" value="MPAB/Lcp_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37539:SF1">
        <property type="entry name" value="ER-BOUND OXYGENASE MPAB_MPAB'_RUBBER OXYGENASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37539">
        <property type="entry name" value="SECRETED PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09995">
        <property type="entry name" value="MPAB_Lcp_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="362"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="449"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="domain" description="ER-bound oxygenase mpaB/mpaB'/Rubber oxygenase catalytic" evidence="3">
        <location>
            <begin position="140"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAG07116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="479" mass="54437" checksum="B468DECFB63F5894" modified="2016-09-07" version="1">MALFNPFRSRTENTRYCWGYEFEWTEGHLTEGKAKVLKQSYDVLAEQCLDRLNEISPPSSGALPRREDPAPAAATATDEEKKEKLPHPQRDLYILLRDNHEADPKLHELWDEVNTVPDWVDWAQIQRGQDVFYRYGGPALTGLTYQSLLGGMGAARVVETLARTGGFSTKVARRRLFETTQHILQCTKSLESIQPGGEGWASSIRVRLLHAAVRQRITKLAKERPSYFNLEEWGVPVNDLDQIATIGTFCATLIWLSFPRQGIFLREQEKKDYVALWRYIGYIMGTPHEHFETPEKAKAIMESLLWNEVHPSDMSKVLANNIIHSLEGQPPTFVSPDMLVASARWLNGNELADELGLPRVSYYYWALMAGQCLFFMGVCYFYRAIPSLDHGHVERLKRIFYNVIVNAKYGLAGIETTFEFKYVPEYDTVTDMGKPREIKLKSSGVEMRNLRALGIFFGVVAIGAYAGIRVASSLVKTIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CJ65</accession>
    <name>A0A177CJ65_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CC84DRAFT_1204532</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG06860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037225.1">
        <property type="nucleotide sequence ID" value="XM_018181909.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CJ65"/>
    <dbReference type="STRING" id="1460663.A0A177CJ65"/>
    <dbReference type="GeneID" id="28765395"/>
    <dbReference type="InParanoid" id="A0A177CJ65"/>
    <dbReference type="OrthoDB" id="433512at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17364">
        <property type="entry name" value="MFS_PhT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24064">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="50"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="99"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="147"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="188"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="238"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="328"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="375"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="407"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="430"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="50"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAG06860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="507" mass="55531" checksum="1A407B95BED5B488" modified="2016-09-07" version="1" fragment="single">MHSPPLSKAGNSAYHDATSVYTHIADPNERRRMALAEVDKAPFGWYHVRLAVVTGIGFFTDAYSLFAINLAVIMLGIVYWQDDVNKGVMPHNADTAIKVATSAGAIFGQVIFGYLADVLGRKKMYGVELMIIISTTLAQSLCGESTAVSVVGVLIFYRVVMGIGVGGDYPLSAVITAEFASTRNRGGIIAAVFAMQGLGQLAAALMALVVVAAYKKDLMAVPDVASCSGDCVAAVDKMWRIIIAFGGIPGWFALYYRLTIPETPRYTFDVLYDVEKASMDTRRYRYGKAGNTVNPVEQAQVRRDMAKYKTPRPTVGEIFRYYSKKRNFIRLFGTSFSWFFLDLAFYGLSFSSASLLSTMGFDKRGSLYENLRNTATGQVVLICAGAIPGYWMTVFTVDRLGRRPIQIGGFAILTIIFCVLGFAWKGLTKIHLLALYVLAQFFFNFGPNATTFITPAEIFPTRVRSTGHGISAGFGKLGAVIAQIFFAPMIKRGATHDNPTPWIHGVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CJH7</accession>
    <name>A0A177CJH7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1258228</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG07018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037383.1">
        <property type="nucleotide sequence ID" value="XM_018184804.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CJH7"/>
    <dbReference type="GeneID" id="28768290"/>
    <dbReference type="InParanoid" id="A0A177CJH7"/>
    <dbReference type="OrthoDB" id="62952at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038883">
        <property type="entry name" value="AN11006-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085:SF2">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG07018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="489" mass="53961" checksum="8A8EB456946E0519" modified="2016-09-07" version="1">MESNGKRDSMDAATDVASKLEETHLHSSSQASTPSKKHPPNLTTLPASVRNKIYAHLLDTELVNIDQPNVSYTHTIKDSTLHFAASRPPFPVHTALFYTNKQLSKEARNYFYSTNLFVKFEVYSADARHAKTMLEDSGVLFSVARPGSVEGCTMHAMELKIVEKDSAVKRASVLFPAQYLPRLVNFMEQACKASGSWAPNHSLILSVVNVYKLEKARVQGDLLELFRLLSNVGRVEVKGKDLLAGYAEALQRSMMAAAFEADTWLKAVTEMTDRAEQALDKKDYDSAAQQCQAATISLTYAYLTRAETLHSQAEGFNKEIQRLRWRTELALATALHSRHAAAISSTSRLVSASTPTAAQKQIAIDLLAAETAASHALSLSTDSPSPASNPWFRSLPPELIPPNKSEWFTDNERGRSWYVLGLTHLAVGECLFAAGDLERAVGLLGEQGDQKGIEEVEQAFARARQEIDWDVRPGVGLRKAACIARREIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CJW5</accession>
    <name>A0A177CJW5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1161888</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG07815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038180.1">
        <property type="nucleotide sequence ID" value="XM_018177852.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CJW5"/>
    <dbReference type="GeneID" id="28761338"/>
    <dbReference type="InParanoid" id="A0A177CJW5"/>
    <dbReference type="OrthoDB" id="5419608at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG07815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="152" mass="16320" checksum="A333AEEF20D6002B" modified="2016-09-07" version="1">MAFASLGVAVAEPAIAIGETSILFTVTDQAQYDQVTKDVLQAMSSYQASITAQPAWSSAYSQLVEFQKTHKGVPAALTDLSTVVQYTATPSWYTAMPSDLQQYLKKEDEARLEFLEDTVEDAMKGSAARPIDIGVYVHGAVATLIAIIAIAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2023-06-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CKB1</accession>
    <name>A0A177CKB1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_654239</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG07308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037673.1">
        <property type="nucleotide sequence ID" value="XM_018187014.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CKB1"/>
    <dbReference type="GeneID" id="28770500"/>
    <dbReference type="InParanoid" id="A0A177CKB1"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG07308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="168" mass="18240" checksum="20A4230633DCB45F" modified="2016-09-07" version="1">MSLRSRLRHASITDVRRVCIALRRRSAARASQTYCLACSPCFHVTRLLEAFHTCTQQLHLTAAHPTPPTPTPYPSATSLSFSLPAQRPPYDAASPSFSRGMLAARRERVLLVASGSAGGSAGVLPQRSAVQRGLRACCAVRNVQVRCKLCVCERARVLDSVRGRELGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CKN8</accession>
    <name>A0A177CKN8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1175228</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG07410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037775.1">
        <property type="nucleotide sequence ID" value="XM_018180140.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CKN8"/>
    <dbReference type="GeneID" id="28763626"/>
    <dbReference type="InParanoid" id="A0A177CKN8"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG07410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="205" mass="23094" checksum="6CC3A1C6D65838EF" modified="2016-09-07" version="1">MEICQGCHTSTVFDQAYLVLSNCVSVRINGRTRETCEYWECKFQAEFLHVTPKETAFVDLSRRSCRVIDLIQKSHFSFESSSADSYSFALAVIFCASSCGSWFLLLSSFSGPHHPLFLSSILVLIYIRFFLLALIHFDPNRCGARLPPEALLSAGGPLSYDVHHDVHVPAGAYPRIPCLCGPGFWSYRDEIWRLDLGAIWNNHPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2023-09-13" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CL80</accession>
    <name>A0A177CL80_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_701660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG07610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037975.1">
        <property type="nucleotide sequence ID" value="XM_018187099.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CL80"/>
    <dbReference type="GeneID" id="28770585"/>
    <dbReference type="InParanoid" id="A0A177CL80"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008058328" description="Secreted protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG07610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="97" mass="11314" checksum="BFD73D92CA119D31" modified="2016-09-07" version="1">MKVLHQLIMMGSTIFNLCHAQRGASLWIHCTIAPTSNTWRVPLEVLIARCPCHVKSATHFQPEHSLVTSCFEEQEFGETYTLSTWRFQWRRILLSVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CLE7</accession>
    <name>A0A177CLE7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1214603</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038426.1">
        <property type="nucleotide sequence ID" value="XM_018182649.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CLE7"/>
    <dbReference type="GeneID" id="28766135"/>
    <dbReference type="InParanoid" id="A0A177CLE7"/>
    <dbReference type="OrthoDB" id="5401654at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39610:SF1">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39610">
        <property type="entry name" value="BZIP DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="253"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="22"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="209"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="269"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG08061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="292" mass="30199" checksum="9F21B95A895625D9" modified="2016-09-07" version="1">MPDLNSVPVSPRGPTSNPTPGAAQAASSATSAQASRQSSATASRRASQIYPMSPPPLPLASPGGTIPVATTHHAHAAPLSPGFAGNIPSFDAAGVPIRHPRPLTAAELHLELEKEQEAVVNRLTRELSALRAHSASVASTASSVTSGVHVDHDIVGATHPTSARRHRSSSSVSRTSTGVPYGIPLNPATASIPHHRYSVSSQPATSDPSAAQQARSASVVSTPRYEEVAHYRQELEEAKRENEVLKRRIRELERVLRGGDAADTQRGRTGAPSSALTGSGATATSATSDAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CLP4</accession>
    <name>A0A177CLP4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">60S ribosomal protein L20</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CC84DRAFT_1144506</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL20 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG07739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038104.1">
        <property type="nucleotide sequence ID" value="XM_018176462.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CLP4"/>
    <dbReference type="FunCoup" id="A0A177CLP4">
        <property type="interactions" value="1209"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CLP4"/>
    <dbReference type="GeneID" id="28759948"/>
    <dbReference type="InParanoid" id="A0A177CLP4"/>
    <dbReference type="OrthoDB" id="1294322at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.10:FF:000001">
        <property type="entry name" value="60S ribosomal protein L18a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L18a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00273">
        <property type="entry name" value="Ribosomal_eL20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028877">
        <property type="entry name" value="Ribosomal_eL20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023573">
        <property type="entry name" value="Ribosomal_eL20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021138">
        <property type="entry name" value="Ribosomal_eL20_eukaryotes"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10052">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L18A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01775">
        <property type="entry name" value="Ribosomal_L18A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002190">
        <property type="entry name" value="Ribosomal_L18a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160374">
        <property type="entry name" value="RplX-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein eL20" evidence="5">
        <location>
            <begin position="12"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR002190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAG07739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="182" mass="21492" checksum="0ECC94DC4A2E5FAD" modified="2016-09-07" version="1">MYGHSLTAIGRLQEYQIIGRHLPSEANPTPKLYRMRIFAPNEVVAKSRFWYFLGKLRKIKKANGEIVSVNQIHEKRPQKVKNFGIWIRYDSRSGTHNMYKEYREMSRTDAVDALYQDMAARHRSRFRSIHILKVVEVEKTADIRRPYIKQLLVKNLKFPLPHRVNKSASKKIFSATRPSTFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CMG2</accession>
    <name>A0A177CMG2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AAA-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CC84DRAFT_1115009</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038851.1">
        <property type="nucleotide sequence ID" value="XM_018175414.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CMG2"/>
    <dbReference type="STRING" id="1460663.A0A177CMG2"/>
    <dbReference type="GeneID" id="28758900"/>
    <dbReference type="InParanoid" id="A0A177CMG2"/>
    <dbReference type="OrthoDB" id="27435at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002219">
        <property type="entry name" value="Transitional endoplasmic reticulum ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050168">
        <property type="entry name" value="AAA_ATPase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077">
        <property type="entry name" value="AAA-FAMILY ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077:SF27">
        <property type="entry name" value="ATPASE FAMILY GENE 2 PROTEIN HOMOLOG A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="4">
        <location>
            <begin position="245"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="4">
        <location>
            <begin position="511"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="311"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAG08486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="746" mass="83150" checksum="4110F233B1469745" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CMG8</accession>
    <name>A0A177CMG8_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Eukaryotic translation initiation factor 3 subunit L</fullName>
            <shortName evidence="4">eIF3l</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CC84DRAFT_1140493</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the eIF-3 subunit L family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038425.1">
        <property type="nucleotide sequence ID" value="XM_018176289.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CMG8"/>
    <dbReference type="STRING" id="1460663.A0A177CMG8"/>
    <dbReference type="GeneID" id="28759775"/>
    <dbReference type="InParanoid" id="A0A177CMG8"/>
    <dbReference type="OrthoDB" id="15082at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03011">
        <property type="entry name" value="eIF3l"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019382">
        <property type="entry name" value="eIF3l"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13242">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13242:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10255">
        <property type="entry name" value="Paf67"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4 6" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="5">
        <location>
            <begin position="238"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAG08060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="456" mass="52674" checksum="3177664A0271AEA4" modified="2016-09-07" version="1">MSDAEEEVMANEYREAAQYDGMDDLDRVPSMGSGGDIQAQLAAAATPLEFQATLETKFASYDNYCNLFHFILNSDGPVDIDAPNSSWAWDVIDEFIYQFNSFCGYRQKVAFKHENPEEIQLLRENPNTWGCYSVLNVLYSLIQRSQISEQLNAVKRGEDAKQYAGEYGSRPLYQMLGYFSVIGLLRVHCLLGDFSLALKTLDDIELNKKSMFPRVMAAQFTTYYYVGFSYMMMRRYADAIRMFSHILVYVSRTKNFQKNAQYDSITKKNDQMYALIMICVAFHPTRLDDTIHTALREKYGEQFNRLQRGGPENLPLFEELFRSACPKFINPTPPDFDNPEINVDPVEHYLGIFMDEVKNTMMSPTVKSYLKLYSTMDLKKLAGFLEVEPEKLRCWLLVNKQRNRQLRWSEGGLLEGDVAHSSDLDYAMEGDLIHVSEAKVGRKLVDWYLRNLARTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CN32</accession>
    <name>A0A177CN32_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7871 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1214817</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038673.1">
        <property type="nucleotide sequence ID" value="XM_018182675.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CN32"/>
    <dbReference type="GeneID" id="28766161"/>
    <dbReference type="InParanoid" id="A0A177CN32"/>
    <dbReference type="OrthoDB" id="4140664at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057193">
        <property type="entry name" value="DUF7871"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40620">
        <property type="entry name" value="RESISTANCE PROTEIN CRD2, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G04318)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40620:SF1">
        <property type="entry name" value="RESISTANCE PROTEIN CRD2, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G04318)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25277">
        <property type="entry name" value="DUF7871"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7871" evidence="2">
        <location>
            <begin position="2"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7871" evidence="2">
        <location>
            <begin position="42"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG08308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="76" mass="8029" checksum="B39C129E5F02AE07" modified="2016-09-07" version="1">MTCCARNNGECLCAKEATCSCGKQPALQCTCDKAATENKMPTNTCQCGKRAEDSCTCGRSSDNGSSSLETDFTTKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CN64</accession>
    <name>A0A177CN64_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">FAD/NAD(P)-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_1162759</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039309.1">
        <property type="nucleotide sequence ID" value="XM_018178087.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CN64"/>
    <dbReference type="STRING" id="1460663.A0A177CN64"/>
    <dbReference type="GeneID" id="28761573"/>
    <dbReference type="InParanoid" id="A0A177CN64"/>
    <dbReference type="OrthoDB" id="47494at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-dep_OxRdtase_2_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47178:SF3">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47178">
        <property type="entry name" value="MONOOXYGENASE, FAD-BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-dependent oxidoreductase 2 FAD-binding" evidence="6">
        <location>
            <begin position="20"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding" evidence="7">
        <location>
            <begin position="133"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAG08944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="414" mass="46184" checksum="4DA8A41020B3A90B" modified="2016-09-07" version="1">MAATPSAAHVANGAAAHLPVLVVGSGSTGLAFAQGLRKAGIRCIVFEKNAPQVGERDWSMGLHWGAPVLKSLMPDEWWPRIQSVHADPSEPPKDPDTMKFVQGDNGNTIAAFPISNFYRLRRSKLRELLSEQVDIRYEKRLASVTFAEDAQSLTAHFSDGTSATGSMLVGADGARSTTRQCLLGPELGAINKIPYCATFVESSYSKEQALFLRSFHPLYLATAHPDNYMGFFSTQSVEDPEDPTTWTFKFYISWRSSLEEQEATAHWTDAQRLAQQKEFAKKFCEPWKSAYEWATEDAGVWYMGMTEWDPGHEGHRWDNHNGLITMVGDAAHPMTYQRGQGLNHSLTDAGKLRDTLVKIREGADRSQAITSFEEEMIQRAGDEVRSCTVNTALLHDWEKVKTSPFYSKGMAKNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CPH7</accession>
    <name>A0A177CPH7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA-directed DNA polymerase</fullName>
            <ecNumber evidence="4">2.7.7.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Mitochondrial DNA polymerase catalytic subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CC84DRAFT_1137077</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Involved in the replication of mitochondrial DNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DNA polymerase type-A family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="4"/>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG09424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039789.1">
        <property type="nucleotide sequence ID" value="XM_018176131.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CPH7"/>
    <dbReference type="FunCoup" id="A0A177CPH7">
        <property type="interactions" value="769"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CPH7"/>
    <dbReference type="GeneID" id="28759617"/>
    <dbReference type="InParanoid" id="A0A177CPH7"/>
    <dbReference type="OrthoDB" id="5588663at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005760">
        <property type="term" value="C:gamma DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006264">
        <property type="term" value="P:mitochondrial DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000035">
        <property type="entry name" value="DNA polymerase gamma, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.390:FF:000003">
        <property type="entry name" value="DNA polymerase gamma, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.390:FF:000006">
        <property type="entry name" value="DNA polymerase gamma, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.390">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019760">
        <property type="entry name" value="DNA-dir_DNA_pol_A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002297">
        <property type="entry name" value="DNA-dir_DNA_pol_A_mt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001098">
        <property type="entry name" value="DNA-dir_DNA_pol_A_palm_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041336">
        <property type="entry name" value="DNApol_Exo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10267">
        <property type="entry name" value="DNA POLYMERASE SUBUNIT GAMMA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10267:SF0">
        <property type="entry name" value="DNA POLYMERASE SUBUNIT GAMMA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00476">
        <property type="entry name" value="DNA_pol_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18136">
        <property type="entry name" value="DNApol_Exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00867">
        <property type="entry name" value="DNAPOLG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00482">
        <property type="entry name" value="POLAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00447">
        <property type="entry name" value="DNA_POLYMERASE_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0235">DNA replication</keyword>
    <keyword evidence="10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA-directed DNA polymerase family A palm" evidence="16">
        <location>
            <begin position="700"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1038"/>
            <end position="1057"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1088"/>
            <end position="1111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00057053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="OAG09424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="1111" mass="125350" checksum="08B84B9460266143" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CQI9</accession>
    <name>A0A177CQI9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_608525</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG09160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039525.1">
        <property type="nucleotide sequence ID" value="XM_018186867.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CQI9"/>
    <dbReference type="GeneID" id="28770353"/>
    <dbReference type="InParanoid" id="A0A177CQI9"/>
    <dbReference type="OrthoDB" id="5400409at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG09160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="156" mass="17965" checksum="7EEAA93EB84CDA00" modified="2016-09-07" version="1">MEMHFPSCDCGSQKEVKQAECRRTVLECNPPKREKFTITQLSAEDSTNVSSWNIALFGQPRHPELDHVETFKGVKWLSLDGQTPEERTELQACLRIISQIRDRQQRDYRAQEDLISRRADRPKERQVRDLPVRTSRASSILSSPSLASESSKFGYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CSQ2</accession>
    <name>A0A177CSQ2_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">FACT complex subunit POB3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CC84DRAFT_1213665</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the SSRP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040691.1">
        <property type="nucleotide sequence ID" value="XM_018182560.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CSQ2"/>
    <dbReference type="FunCoup" id="A0A177CSQ2">
        <property type="interactions" value="993"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CSQ2"/>
    <dbReference type="GeneID" id="28766046"/>
    <dbReference type="InParanoid" id="A0A177CSQ2"/>
    <dbReference type="OrthoDB" id="498543at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035101">
        <property type="term" value="C:FACT complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006335">
        <property type="term" value="P:DNA replication-dependent chromatin assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034728">
        <property type="term" value="P:nucleosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031508">
        <property type="term" value="P:pericentric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045899">
        <property type="term" value="P:positive regulation of RNA polymerase II transcription preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030466">
        <property type="term" value="P:silent mating-type cassette heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031509">
        <property type="term" value="P:subtelomeric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd13230">
        <property type="entry name" value="PH1_SSRP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13231">
        <property type="entry name" value="PH2_SSRP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13229">
        <property type="entry name" value="PH_TFIIH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.220:FF:000003">
        <property type="entry name" value="FACT complex subunit POB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000146">
        <property type="entry name" value="FACT complex subunit POB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.150:FF:000001">
        <property type="entry name" value="Fact complex subunit ssrp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.220">
        <property type="entry name" value="Structure-specific recognition protein (SSRP1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013719">
        <property type="entry name" value="RTT106/SPT16-like_middle_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050454">
        <property type="entry name" value="RTT106/SSRP1_HistChap/FACT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048993">
        <property type="entry name" value="SSRP1-like_PH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000969">
        <property type="entry name" value="SSRP1/POB3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035417">
        <property type="entry name" value="SSRP1/POB3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024954">
        <property type="entry name" value="SSRP1_DD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038167">
        <property type="entry name" value="SSRP1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45849">
        <property type="entry name" value="FACT COMPLEX SUBUNIT SSRP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45849:SF1">
        <property type="entry name" value="FACT COMPLEX SUBUNIT SSRP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21103">
        <property type="entry name" value="PH1_SSRP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17292">
        <property type="entry name" value="POB3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08512">
        <property type="entry name" value="Rttp106-like_middle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03531">
        <property type="entry name" value="SSrecog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00887">
        <property type="entry name" value="SSRCOGNITION"/>
    </dbReference>
    <dbReference type="SMART" id="SM01287">
        <property type="entry name" value="Rtt106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 10" id="KW-0158">Chromosome</keyword>
    <keyword evidence="4 10" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7 10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 10" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 10" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Histone chaperone RTT106/FACT complex subunit SPT16-like middle" evidence="12">
        <location>
            <begin position="382"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="495"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="523"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="540"/>
            <end position="562"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OAG10326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="574" mass="64244" checksum="AD5249756EA6FBAC" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CSZ9</accession>
    <name>A0A177CSZ9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1213960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041018.1">
        <property type="nucleotide sequence ID" value="XM_018182594.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CSZ9"/>
    <dbReference type="GeneID" id="28766080"/>
    <dbReference type="InParanoid" id="A0A177CSZ9"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="22"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG10653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="86" mass="8850" checksum="739C88A3E60FCEE9" modified="2016-09-07" version="1">MSSSSYSYGSSYAQDKSKSYASRSSSPRSTTSTSSSTSSSSLYAHRGHSTRNNRYGSKPGSAVIHNGGGQSTGPSSTSAGNSGYYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CT26</accession>
    <name>A0A177CT26_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Acyl-CoA dehydrogenase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CC84DRAFT_1112745</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040811.1">
        <property type="nucleotide sequence ID" value="XM_018175329.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CT26"/>
    <dbReference type="STRING" id="1460663.A0A177CT26"/>
    <dbReference type="GeneID" id="28758815"/>
    <dbReference type="InParanoid" id="A0A177CT26"/>
    <dbReference type="OrthoDB" id="10016597at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046359">
        <property type="term" value="P:butyrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033539">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA dehydrogenase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00567">
        <property type="entry name" value="ACAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884:SF12">
        <property type="entry name" value="ISOVALERYL-COA DEHYDROGENASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase N-terminal" evidence="6">
        <location>
            <begin position="10"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="5">
        <location>
            <begin position="270"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAG10446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="434" mass="45901" checksum="B4CC78F81156A062" modified="2016-09-07" version="1">MPIDFHLSPTESGVRAAAQTFARDVLIPSRRAPSSSAVSQQDRFAGTRALYEAAVTLGLIKAQIAAPLGGTGGSLVEAALLVEECYAADPSGASLTVFGTALGLMPLQLAPHAEKYVGFLEPFLMAGEGDAPLASLVFSEPGGTANWLEKGAPGLQTTVRKEGEEWVVSGEKVWGTNCAGWDGRGAELQVVVCRDVTTAAREGEDPKERIVIVLVTRADIVRNDDAAFQVVQHLETMGHKSYSGAHVRFTHLRVPQANILCGPGPQAVRTVLSSFDNTGVLVGAMAVGVMRAAFDAALAFAKADSRRGATPLLERQAVADKLGDIKMNAEACRALTWKAGHALGNGPGEYQERRELALATKVFCSEAAVKAVMDAISVVGVTAYDTAQPFAELLNTAIALPIFDGGNVAMRRRHMQDIMLSPNYDPWGATFGQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CTC1</accession>
    <name>A0A177CTC1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Flavin reductase like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1112932</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040901.1">
        <property type="nucleotide sequence ID" value="XM_018175337.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CTC1"/>
    <dbReference type="STRING" id="1460663.A0A177CTC1"/>
    <dbReference type="GeneID" id="28758823"/>
    <dbReference type="InParanoid" id="A0A177CTC1"/>
    <dbReference type="OrthoDB" id="298012at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002563">
        <property type="entry name" value="Flavin_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43812">
        <property type="entry name" value="BLR2425 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43812:SF2">
        <property type="entry name" value="FLAVIN REDUCTASE LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01613">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00903">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavin reductase like" evidence="1">
        <location>
            <begin position="19"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG10536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="247" mass="26996" checksum="E0305502A19D545E" modified="2016-09-07" version="1">MFYEPGKTDHGLPHDPFKACVIPRPIGWISTLSPSGTANLAPYSQFNNLTFDPPYVMFSANQTPSAAQKDTVVNVEATGVFCWNLATYALKDAVNATSEQTPPEVDEFEKAGLSKEDSSLSSVLVKGKQVKVPMVKASPIKFECTHYTTLRLPGNPPMGAVDVIIGRVIGIHIDEDVLTDGRIDVSKTVPIARCGYFEYTAVREVFEMKIPGDDPNRYAGLEGSVKGNREIQMKRVEEAEKEKTGGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CTI8</accession>
    <name>A0A177CTI8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1213436</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040434.1">
        <property type="nucleotide sequence ID" value="XM_018182529.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CTI8"/>
    <dbReference type="GeneID" id="28766015"/>
    <dbReference type="InParanoid" id="A0A177CTI8"/>
    <dbReference type="OrthoDB" id="5430111at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG10069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="372" mass="40740" checksum="1F6146DC0D80E204" modified="2016-09-07" version="1">MPPALSDYESDRDNATPTSSKRGSSPSRTRKSGGLLNGLDAGNIITSDEVIISTVKDNTPTSSYLTRGSTRGARSNDLAYDQSYHPVDEYIRPYQAAKRRAEHGLEDTNSVHSVESDTDTDAEDQPQPKKRKLNTIIIRGTRRSSRRTNHNVLYNMKIHPQDSQLEQLVGDTVDEAAEEDAEMISIGSSEAAEEEDEQVVGDTTGKSPLSLFKYTFHLIDVSPLLLYRSVVASISNVHADEASSLTISSPLHSTPLSTVSTTNKVQQSLSNELHTNRSATPRVESTYSALHEGPFHTQFKNKSASPAPLGCDHDDKSPNIIDQYLHPAMFDGPCDQVDVTHPHDFSAKMHDQVGNIDSDSVLGRDIDPAISE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CTX0</accession>
    <name>A0A177CTX0_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cx9C motif-containing protein 4, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CC84DRAFT_1161203</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CMC4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040592.1">
        <property type="nucleotide sequence ID" value="XM_018177677.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CTX0"/>
    <dbReference type="FunCoup" id="A0A177CTX0">
        <property type="interactions" value="94"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CTX0"/>
    <dbReference type="GeneID" id="28761163"/>
    <dbReference type="InParanoid" id="A0A177CTX0"/>
    <dbReference type="OrthoDB" id="13601at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1130">
        <property type="entry name" value="CytochromE C oxidase copper chaperone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027179">
        <property type="entry name" value="CMC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009069">
        <property type="entry name" value="Cys_alpha_HP_mot_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15590">
        <property type="entry name" value="CX9C MOTIF-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15590:SF0">
        <property type="entry name" value="CX9C MOTIF-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08991">
        <property type="entry name" value="CMC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47072">
        <property type="entry name" value="Cysteine alpha-hairpin motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="13"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="23"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="45"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR627179-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAG10227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="78" mass="9144" checksum="75133C5C17BF44CE" modified="2016-09-07" version="1">MGSKEDTRTDPPCISRACAIQNCLQKSNYKEERCRKEVDALYECCNKFYQEKGEDASSVCCPKYELLKYWLQFCIVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CTY8</accession>
    <name>A0A177CTY8_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Nucleoporin Nup54 alpha-helical domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CC84DRAFT_475690</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040612.1">
        <property type="nucleotide sequence ID" value="XM_018186415.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CTY8"/>
    <dbReference type="FunCoup" id="A0A177CTY8">
        <property type="interactions" value="99"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CTY8"/>
    <dbReference type="GeneID" id="28769901"/>
    <dbReference type="InParanoid" id="A0A177CTY8"/>
    <dbReference type="OrthoDB" id="2538017at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008139">
        <property type="term" value="F:nuclear localization sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025574">
        <property type="entry name" value="Nucleoporin_FG_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024882">
        <property type="entry name" value="NUP58/p45/49"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13437">
        <property type="entry name" value="NUCLEOPORIN P58/P45 NUCLEOPORIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13437:SF2">
        <property type="entry name" value="NUCLEOPORIN P58_P45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13634">
        <property type="entry name" value="Nucleoporin_FG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21121">
        <property type="entry name" value="Nup49_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="6" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0811">Translocation</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="29"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="29"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="51"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="105"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="141"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAG10247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="448" mass="47405" checksum="90CEBBD8A648EFC6" modified="2016-09-07" version="1">MAGFGRSNSLSINTGSSLFGNATSQGQQSARLFGSSTAASQPQQTGGLFGGASQAQSSQPPQSAGLFGSLNKPQQPAPTAGGLFGASTQQPQPQQGSSLFGGALGANANTQNQTQPAQTGGLFGNFGQSQNQNQAKPSLFGASTAQQNTGSSLFGNAQQQQNQTSTPSLFGNLQQNQTQQSNTLFGGMNSQNNTLGGLGQSSNLGGSQVIQMNDLSQIKGTTRLNDLHPDIQKQVFGLDDAIQARIDDVNKMRETYPGHIQKLETIAPDVEYVEKKLATVALGLENDAANIAHLKTIVDHDANDAELSFRAIVNQALPAQFRYGNPSNLSASTAKPASAGSLENDDPTKPVDLIAYFNRRTDDLGKTLQTYQSQIREIEMHLKTMEHGVLEKNQQLAGARNRSLDDRQQLVEALRAIESAIMDSAKKVGKVRDDVTRHTLGGAGAPLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CU45</accession>
    <name>A0A177CU45_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF1446-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_1256504</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041106.1">
        <property type="nucleotide sequence ID" value="XM_018184632.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CU45"/>
    <dbReference type="GeneID" id="28768118"/>
    <dbReference type="InParanoid" id="A0A177CU45"/>
    <dbReference type="OrthoDB" id="10265871at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056362">
        <property type="entry name" value="AtuA-like_ferredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010839">
        <property type="entry name" value="AtuA_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47585">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47585:SF2">
        <property type="entry name" value="DUF1446 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G11420)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07287">
        <property type="entry name" value="AtuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23544">
        <property type="entry name" value="AtuA_ferredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyclic terpene utilisation N-terminal" evidence="2">
        <location>
            <begin position="31"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="domain" description="AtuA-like ferredoxin-fold" evidence="3">
        <location>
            <begin position="534"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAG10741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="643" mass="70616" checksum="78EA7CE6B79F9FE9" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CVC4</accession>
    <name>A0A177CVC4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">EI24-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1224695</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG11514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041879.1">
        <property type="nucleotide sequence ID" value="XM_018183546.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CVC4"/>
    <dbReference type="FunCoup" id="A0A177CVC4">
        <property type="interactions" value="73"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CVC4"/>
    <dbReference type="GeneID" id="28767032"/>
    <dbReference type="InParanoid" id="A0A177CVC4"/>
    <dbReference type="OrthoDB" id="2107885at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005619">
        <property type="term" value="C:ascospore wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005628">
        <property type="term" value="C:prospore membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052786">
        <property type="entry name" value="Spore_wall_assembly"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34292">
        <property type="entry name" value="OUTER SPORE WALL PROTEIN LDS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34292:SF1">
        <property type="entry name" value="OUTER SPORE WALL PROTEIN RRT8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="231"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG11514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="286" mass="32713" checksum="9646893302A21E4F" modified="2016-09-07" version="1">MPQPQAGLTENVKRVIVQPTWENVVASSYQIKGIIYFLGHPFLYPLARRRLLPAVLLSVFVLANLFVWAYLPQVAFLALFQKKGSAWVNGTFLVLGESAAVTALLFEAWLVDEVQVDIFDAVLVHKGYDDLVRQFRPVSDDSLNNPVQRLGKPTKSSVYAPFSFRQIAEFVILLPLNFVPYIGVPIFLLLTGYRAGPLQHWRYFKLLDFNKKQRNAFARRRVWQYTWYGTVYLFLQLVPPLSMFFLLTAPVSSALWAADLEARRRQQETDVVQAPAYTDQPPDDQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CVZ5</accession>
    <name>A0A177CVZ5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Kinesin light chain 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1173335</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG11040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041405.1">
        <property type="nucleotide sequence ID" value="XM_018180024.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CVZ5"/>
    <dbReference type="STRING" id="1460663.A0A177CVZ5"/>
    <dbReference type="GeneID" id="28763510"/>
    <dbReference type="InParanoid" id="A0A177CVZ5"/>
    <dbReference type="OrthoDB" id="1658288at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053137">
        <property type="entry name" value="NLR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082:SF6">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082">
        <property type="entry name" value="ATP/GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
        <property type="entry name" value="NB-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13374">
        <property type="entry name" value="TPR_10"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="2">
        <location>
            <begin position="25"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="NB-ARC" evidence="1">
        <location>
            <begin position="275"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG11040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="1129" mass="128242" checksum="038C316179725A51" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CW33</accession>
    <name>A0A177CW33_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CC84DRAFT_51075</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG11774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042139.1">
        <property type="nucleotide sequence ID" value="XM_018186567.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CW33"/>
    <dbReference type="GeneID" id="28770053"/>
    <dbReference type="InParanoid" id="A0A177CW33"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000134">
        <property type="entry name" value="MFS sugar transporter protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF14">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="117"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="169"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="201"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="358"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="389"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="459"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="23"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAG11774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="527" mass="58428" checksum="14E043FC8ED5FA79" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CW54</accession>
    <name>A0A177CW54_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA 3'-5' helicase</fullName>
            <ecNumber evidence="3">5.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CC84DRAFT_1084769</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family. RecQ subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="3"/>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG11100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041465.1">
        <property type="nucleotide sequence ID" value="XM_018174067.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CW54"/>
    <dbReference type="STRING" id="1460663.A0A177CW54"/>
    <dbReference type="GeneID" id="28757553"/>
    <dbReference type="InParanoid" id="A0A177CW54"/>
    <dbReference type="OrthoDB" id="2608216at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710">
        <property type="entry name" value="DNA HELICASE RECQ FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710:SF154">
        <property type="entry name" value="RECQ HELICASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G14720)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase C-terminal" evidence="4">
        <location>
            <begin position="1"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00034808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAG11100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="117" mass="12630" checksum="BB04E26BA9A42DC9" modified="2016-09-07" version="1">MSRRQMQALQDGMKGIVYCRSKAQCAVLAEALQCPCYRADIPDRGTRLTQSLEKGGSIVATSALGTGVDFTGILFILHVGMPWSMIDYCQESGQAGRSGEAASLVIIVEQGEVARRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CX57</accession>
    <name>A0A177CX57_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DUF300-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CC84DRAFT_1133575</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG11628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041993.1">
        <property type="nucleotide sequence ID" value="XM_018175983.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CX57"/>
    <dbReference type="STRING" id="1460663.A0A177CX57"/>
    <dbReference type="GeneID" id="28759469"/>
    <dbReference type="InParanoid" id="A0A177CX57"/>
    <dbReference type="OrthoDB" id="5348404at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005178">
        <property type="entry name" value="Ostalpha/TMEM184C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23423">
        <property type="entry name" value="ORGANIC SOLUTE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03619">
        <property type="entry name" value="Solute_trans_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01417">
        <property type="entry name" value="Solute_trans_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="49"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="171"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="206"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="239"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="284"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAG11628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="386" mass="42610" checksum="9400C4A74F82D2B3" modified="2016-09-07" version="1">MDVAYLVARKLFDHNDNKNSTDDACPEDPTNVPADQMKAVVGSLMFHDFATILAGACSLAALLIVSVAIVRHATNFTNPIQQRQVIRILMLVPWVALFSFLIVWQEDVGEYLVESLDFGCSIAISAFLLLLCDYILSNPGGFDELFGQGASKVAREGVDSPKWLKRTWYMVLQYFPVSIIVWLATAISLAVGTYCGASNKPRFAHIWLQVIKIVSTMFAVLACFRFYKMKKDQLAPHKVMLKFLAFKGIIGLNVLQVFIIGILVGNGTIKPTEHMTYHDIKTALPSLILACEMPLFALLLVFAFPVGVYKAEGCSPAAGPLSAMAQAFNITDLMSCFVRGPMRLLREQQWGMQRAQSFPLHAEGGVVVSEGGYTAEPYGYNAHPRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CXH4</accession>
    <name>A0A177CXH4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1211827</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042598.1">
        <property type="nucleotide sequence ID" value="XM_018182404.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CXH4"/>
    <dbReference type="GeneID" id="28765890"/>
    <dbReference type="InParanoid" id="A0A177CXH4"/>
    <dbReference type="OrthoDB" id="3754631at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008058759" evidence="1">
        <location>
            <begin position="18"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG12233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="96" mass="9772" checksum="728B8511696D6986" modified="2016-09-07" version="1">MKLSATLLLTLTTSVLAAPVAQSSYSEYGSYSNVPAPAGGYGSYGDYKGVAAPPVENPPAPAAGYGDYSNVPAPAGGYGSYGTYKRGAEKQEEVKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CXQ6</accession>
    <name>A0A177CXQ6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CC84DRAFT_1192028</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG11499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041864.1">
        <property type="nucleotide sequence ID" value="XM_018181221.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CXQ6"/>
    <dbReference type="STRING" id="1460663.A0A177CXQ6"/>
    <dbReference type="GeneID" id="28764707"/>
    <dbReference type="InParanoid" id="A0A177CXQ6"/>
    <dbReference type="OrthoDB" id="160645at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054293">
        <property type="entry name" value="DUF7029"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055647">
        <property type="entry name" value="DUF7223"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22974">
        <property type="entry name" value="DUF7029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23865">
        <property type="entry name" value="DUF7223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008058723" evidence="2">
        <location>
            <begin position="20"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7029" evidence="3">
        <location>
            <begin position="72"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7223" evidence="4">
        <location>
            <begin position="269"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="523"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="574"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="574"/>
            <end position="678"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAG11499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="687" mass="72205" checksum="D5780300989CD204" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CXQ9</accession>
    <name>A0A177CXQ9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyl-CoA N-acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1107272</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG11617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041982.1">
        <property type="nucleotide sequence ID" value="XM_018175169.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CXQ9"/>
    <dbReference type="GeneID" id="28758655"/>
    <dbReference type="InParanoid" id="A0A177CXQ9"/>
    <dbReference type="OrthoDB" id="64477at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43415:SF3">
        <property type="entry name" value="GNAT-FAMILY ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43415">
        <property type="entry name" value="SPERMIDINE N(1)-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="2">
        <location>
            <begin position="104"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="84"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG11617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="229" mass="25773" checksum="7808AEBE5B29E8F2" modified="2016-09-07" version="1">MAPQKDPFRSARLIYRAVRGAEDDAVFAAINDDPIGYMNSNAGNNHLPGPSDAERFRKSMDDNLLSAIICLPEDLPAPPPPPGSSSTPETTTTTANSNPNPRAGTPIGQIHLSNLSPRMRHHRNTEIGIDILPAYQGRGYGSEAIRWVLDYAFHRAGLHKVRIRAFEWNEGACRLYQRLGFVEEGRERESLWHEGRWWDGVEFGMVEGEWRALVEEEKKKKGEEKEVVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CYB0</accession>
    <name>A0A177CYB0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DUF423-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CC84DRAFT_1108988</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042888.1">
        <property type="nucleotide sequence ID" value="XM_018175212.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CYB0"/>
    <dbReference type="GeneID" id="28758698"/>
    <dbReference type="InParanoid" id="A0A177CYB0"/>
    <dbReference type="OrthoDB" id="269173at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006696">
        <property type="entry name" value="DUF423"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43461">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43461:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04241">
        <property type="entry name" value="DUF423"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="97"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAG12523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="124" mass="13279" checksum="18E48B758D9789C1" modified="2016-09-07" version="1">MPPFWTIGTLYGATSVAVGAFGAHGLKKRIADPQRITNWSTAAQYQLIHSAVLTFASVVAPQNTLAMGLFTAGMTMFSGSIYLLVLDPQRWKFLGPVTPLGGLCLIGGWVALAVGKRPIMPKFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2023-06-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CYG9</accession>
    <name>A0A177CYG9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1159883</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042960.1">
        <property type="nucleotide sequence ID" value="XM_018177354.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CYG9"/>
    <dbReference type="GeneID" id="28760840"/>
    <dbReference type="InParanoid" id="A0A177CYG9"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG12595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="118" mass="13204" checksum="9D4E128E1BD9DB65" modified="2016-09-07" version="1">MAPLVSRYIASSVTCLSRSRAADMSPRGCGVLGPPHTYPASLLRISSLALRLLNPAESYVLVFTCCRISDPRHMQSLLIIRAIVSLKQSSYDPCRRYVTRGLHQIQVQMYLLQQRILG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2023-06-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CYH7</accession>
    <name>A0A177CYH7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_58094</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG11870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042235.1">
        <property type="nucleotide sequence ID" value="XM_018186758.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CYH7"/>
    <dbReference type="GeneID" id="28770244"/>
    <dbReference type="InParanoid" id="A0A177CYH7"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG11870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="149" mass="16276" checksum="40FA1A5ECD145820" modified="2016-09-07" version="1">MDLIDARKALFTVSIDKNCCIPPKSMSVYLQEGMSSSLYISHQCKLSPARILREKQAPQQRRVGAQAAVSSNGAHLHICNQPTLSTTVITLQACKSPPIGRRAVAVPDAFARLACCGRGELGARASGSWLRARQRSTRCGRQFERVTHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CZ36</accession>
    <name>A0A177CZ36_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DnaJ-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1226004</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042465.1">
        <property type="nucleotide sequence ID" value="XM_018183580.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CZ36"/>
    <dbReference type="STRING" id="1460663.A0A177CZ36"/>
    <dbReference type="GeneID" id="28767066"/>
    <dbReference type="InParanoid" id="A0A177CZ36"/>
    <dbReference type="OrthoDB" id="10250354at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031072">
        <property type="term" value="F:heat shock protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052594">
        <property type="entry name" value="J_domain-containing_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44144">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44144:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="7"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="241"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="330"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="354"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="431"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="448"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="465"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG12100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="571" mass="64952" checksum="6B097E2D5316FE8E" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CZN7</accession>
    <name>A0A177CZN7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1160215</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018043338.1">
        <property type="nucleotide sequence ID" value="XM_018177442.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CZN7"/>
    <dbReference type="STRING" id="1460663.A0A177CZN7"/>
    <dbReference type="GeneID" id="28760928"/>
    <dbReference type="InParanoid" id="A0A177CZN7"/>
    <dbReference type="OrthoDB" id="10249419at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="entry name" value="2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35006">
        <property type="entry name" value="GLYOXALASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_5G14830)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35006:SF2">
        <property type="entry name" value="GLYOXALASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_5G14830)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG12973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="74" mass="8214" checksum="98E6EBE31A0E48A7" modified="2016-09-07" version="1">MHVAFTVNSIEQLYEWHAAAVRAGGEDNGKPGPREEYHAGYHGAFVRDPVLGVNFEVVYREPNGKSIRLGESTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177D015</accession>
    <name>A0A177D015_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">LYC1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1159970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018043063.1">
        <property type="nucleotide sequence ID" value="XM_018177373.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177D015"/>
    <dbReference type="STRING" id="1460663.A0A177D015"/>
    <dbReference type="GeneID" id="28760859"/>
    <dbReference type="InParanoid" id="A0A177D015"/>
    <dbReference type="OrthoDB" id="2020070at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055100">
        <property type="entry name" value="GNAT_LYC1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053013">
        <property type="entry name" value="LAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34815">
        <property type="entry name" value="LYSINE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34815:SF4">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22998">
        <property type="entry name" value="GNAT_LYC1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LYC1 C-terminal" evidence="1">
        <location>
            <begin position="177"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF22998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG12698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="407" mass="45843" checksum="D79B6107C62CA365" modified="2016-09-07" version="1">MGSLVQLPHGSSPDLALVHPTLEEKLIQFNLNGAEWRGALSQEAYLRREDVLSQQDQTKDGGISYWILIDKTANRNPLDPTSSARLPLASCETYRKKALVWQDGELKETICHGIGSVFCAPHLRGRKYAQRMMQELGEALRTYQTDEKTDCMFSVLFSDIGKKFYSDFGWEAFRSSHVSLPGETSKVKDPGSLPAARPLYAEDLAELCKIDEELIRKSLQERPKGSHAAVALVPNIANIRWHHAREEFVGGELHGNAPRVKGAIVGTEKGKRVWCYWTRMWYNPDATQAKDNTLHILRFVVEDQGRSSWEGSGTKHVEEASNDHSHDAAIAALFYAAQQQAEEWKMEHVEAWNPSSATLAAARRLDPNAKLIDRDMESIASLKWYPQHDGPVAESIDWIGNEKYGWC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177D0H7</accession>
    <name>A0A177D0H7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1159770</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042824.1">
        <property type="nucleotide sequence ID" value="XM_018177324.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177D0H7"/>
    <dbReference type="STRING" id="1460663.A0A177D0H7"/>
    <dbReference type="GeneID" id="28760810"/>
    <dbReference type="InParanoid" id="A0A177D0H7"/>
    <dbReference type="OrthoDB" id="21225at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG12459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="175" mass="19393" checksum="8E42DA316EBFA4F9" modified="2016-09-07" version="1">MASTCTQQELVFFPKADAAVLTSKPPPDYPLAVGPIFDPDSVNTPVSPWPVDAEETHYPPMKDAVAPAPVPDKQVCATDRYLRAPLTKNERYRLSMVWYYTRDIFEEAEFLAGLQEKVCIAQESTGWEFAVIGILDVNYYTRLATIGLPLAILPRGETICAHTVAQPPGVRAQRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177D0V7</accession>
    <name>A0A177D0V7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CC84DRAFT_158125</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HTATSF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018043115.1">
        <property type="nucleotide sequence ID" value="XM_018185414.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177D0V7"/>
    <dbReference type="FunCoup" id="A0A177D0V7">
        <property type="interactions" value="67"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177D0V7"/>
    <dbReference type="GeneID" id="28768900"/>
    <dbReference type="InParanoid" id="A0A177D0V7"/>
    <dbReference type="OrthoDB" id="10258585at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005684">
        <property type="term" value="C:U2-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000105">
        <property type="entry name" value="HIV Tat-specific factor 1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034393">
        <property type="entry name" value="TatSF1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15608:SF0">
        <property type="entry name" value="HIV TAT-SPECIFIC FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15608">
        <property type="entry name" value="SPLICING FACTOR U2AF-ASSOCIATED PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="9">
        <location>
            <begin position="60"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="295"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="163"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="17"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="295"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAG12750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="331" mass="37318" checksum="312405E03D5F7CEB" modified="2016-09-07" version="1">MSGRQDIEDSVAAVPANSGSPEAQNTGGATVDHGTGQKRKEAPTTAGASTKKQQKAIENRAIYASNIPRDATFEEIEETFKKAGIIEKGVDGKPRIKMYTDEDGKFNGDVLIVYFKKESIELAIMRYDGWPFRLDAQKSEGVIKVEEADMSFKKNTDGEVVKSKLVRKDRKAAERTRAELNRKLAEWSEDEEEEVQKAFAPKKNKWSKYVIIKKAFTLAQINDKEDEGAVLEIKEDMREAAEKFGEVTKVVLYDKEAEGILTVRFKEFEGAEAFVLAFDGKGYNHQKLQLSIADDRPRFQKSGKEDTSDVEDNVRRMEAYMDGDKTDEDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177D113</accession>
    <name>A0A177D113_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CC84DRAFT_1109581</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018043185.1">
        <property type="nucleotide sequence ID" value="XM_018175230.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177D113"/>
    <dbReference type="STRING" id="1460663.A0A177D113"/>
    <dbReference type="GeneID" id="28758716"/>
    <dbReference type="InParanoid" id="A0A177D113"/>
    <dbReference type="OrthoDB" id="3971593at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000435">
        <property type="term" value="P:positive regulation of transcription from RNA polymerase II promoter by galactose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051127">
        <property type="entry name" value="Fungal_SecMet_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424:SF5">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="42"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="124"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="132"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="149"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAG12820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="727" mass="80473" checksum="744CD2E9D12D7E96" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BTQ0</accession>
    <name>A0A177BTQ0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1170049</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441567">
        <property type="protein sequence ID" value="OAF98545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018028911.1">
        <property type="nucleotide sequence ID" value="XM_018179825.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BTQ0"/>
    <dbReference type="STRING" id="1460663.A0A177BTQ0"/>
    <dbReference type="GeneID" id="28763311"/>
    <dbReference type="InParanoid" id="A0A177BTQ0"/>
    <dbReference type="OrthoDB" id="10546125at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051750">
        <property type="term" value="F:delta(3,5)-delta(2,4)-dienoyl-CoA isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045002">
        <property type="entry name" value="Ech1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43149:SF1">
        <property type="entry name" value="DELTA(3,5)-DELTA(2,4)-DIENOYL-COA ISOMERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43149">
        <property type="entry name" value="ENOYL-COA HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008057400" evidence="2">
        <location>
            <begin position="38"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAF98545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="95" mass="10542" checksum="BDACC5D50E8C52F6" modified="2016-09-07" version="1">MAGSGQPCECRRRPLVWQSHHVLVFLCATFAPATVDSARKANGLRRHILEFQDCITSLEKCEKPVICMLHGISFGLALGMSLSCDVRISLRASWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BTS3</accession>
    <name>A0A177BTS3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="8">PPIase</shortName>
            <ecNumber evidence="8">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CC84DRAFT_1169942</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the cyclophilin-type PPIase family.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="8"/>
    <dbReference type="EMBL" id="KV441564">
        <property type="protein sequence ID" value="OAF98812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029178.1">
        <property type="nucleotide sequence ID" value="XM_018179796.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BTS3"/>
    <dbReference type="FunCoup" id="A0A177BTS3">
        <property type="interactions" value="654"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177BTS3"/>
    <dbReference type="GeneID" id="28763282"/>
    <dbReference type="InParanoid" id="A0A177BTS3"/>
    <dbReference type="OrthoDB" id="193499at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016018">
        <property type="term" value="F:cyclosporin A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000032">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071:SF385">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0697">Rotamase</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="9">
        <location>
            <begin position="74"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAF98812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="227" mass="24557" checksum="5A532DF0DBDD2251" modified="2016-09-07" version="1">MPHHALRTSTSLLSAFRSSQSSPLRAPLNKRNFSPSTANMVIKTYFDVSWYGPEVQVNSNGDVTSKGAEKDQSGRINFELFDDVVPKTAENFRALCTGEKGFGYSGSKFHRVIPQFMLQGGDFTRGNGTGGKSIYGEKFSDENFKLKHDKPFLLSMANAGPNTNGSQFFVTTVVTSWLDGKHVVFGRVPAGDVESMKIVRAIEAVGSNSGAVKYSSKPPTITGSGQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BUD1</accession>
    <name>A0A177BUD1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">YTH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CC84DRAFT_1223494</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441564">
        <property type="protein sequence ID" value="OAF98745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029111.1">
        <property type="nucleotide sequence ID" value="XM_018183497.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BUD1"/>
    <dbReference type="STRING" id="1460663.A0A177BUD1"/>
    <dbReference type="GeneID" id="28766983"/>
    <dbReference type="InParanoid" id="A0A177BUD1"/>
    <dbReference type="OrthoDB" id="306690at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990247">
        <property type="term" value="F:N6-methyladenosine-containing RNA reader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000381">
        <property type="term" value="P:regulation of alternative mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21134">
        <property type="entry name" value="YTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.590.10">
        <property type="entry name" value="ph1033 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057720">
        <property type="entry name" value="RRM_YTH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007275">
        <property type="entry name" value="YTH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045168">
        <property type="entry name" value="YTH_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12357:SF3">
        <property type="entry name" value="YTH DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12357">
        <property type="entry name" value="YTH YT521-B HOMOLOGY DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25701">
        <property type="entry name" value="RRM_YTH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04146">
        <property type="entry name" value="YTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50882">
        <property type="entry name" value="YTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="318"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="YTH" evidence="4">
        <location>
            <begin position="453"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="74"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="178"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="393"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="571"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="178"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="571"/>
            <end position="583"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAF98745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="673" mass="73031" checksum="BD53D378ECBB8265" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BUG8</accession>
    <name>A0A177BUG8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1181940</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441564">
        <property type="protein sequence ID" value="OAF98785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029151.1">
        <property type="nucleotide sequence ID" value="XM_018180582.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BUG8"/>
    <dbReference type="GeneID" id="28764068"/>
    <dbReference type="InParanoid" id="A0A177BUG8"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAF98785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="187" mass="21251" checksum="F2B210DC35F22371" modified="2016-09-07" version="1">MPNSRWISAVLPTGSRTWSGVNVYGKCSESIRDTLLVVRAANLLATCIEMGQVSERLTLRVTDVVKVFRNIDDPWLGCLRSLSHVECFNFGIIYRHSPMISTPLIDLTVDYPFGYPQPNCDHFYPSGLEFIMGPTEPNPSSTTSIDRDDIFLPRRSQMEQHRSERESVATAPPPKRLARRDLQLRNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BUV1</accession>
    <name>A0A177BUV1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Dipeptidyl-peptidase V</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_1169782</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S9C family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441563">
        <property type="protein sequence ID" value="OAF99084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029450.1">
        <property type="nucleotide sequence ID" value="XM_018179758.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BUV1"/>
    <dbReference type="STRING" id="1460663.A0A177BUV1"/>
    <dbReference type="GeneID" id="28763244"/>
    <dbReference type="InParanoid" id="A0A177BUV1"/>
    <dbReference type="OrthoDB" id="416344at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000028">
        <property type="entry name" value="S9 family peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42776:SF13">
        <property type="entry name" value="DIPEPTIDYL-PEPTIDASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42776">
        <property type="entry name" value="SERINE PEPTIDASE S9 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0720">Serine protease</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Peptidase S9 prolyl oligopeptidase catalytic" evidence="7">
        <location>
            <begin position="503"/>
            <end position="712"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAF99084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="728" mass="80797" checksum="6CE161AE25B981FE" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2023-09-13" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BV15</accession>
    <name>A0A177BV15_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF4939 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1106182</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441571">
        <property type="protein sequence ID" value="OAF98498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018028864.1">
        <property type="nucleotide sequence ID" value="XM_018175131.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BV15"/>
    <dbReference type="GeneID" id="28758617"/>
    <dbReference type="InParanoid" id="A0A177BV15"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAF98498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="53" mass="6381" checksum="C7A9DF7616265849" modified="2016-09-07" version="1" fragment="single">LDLYFYEENKDKDNKDKVLFTASYIRGDIGEWIQPYITKYLDINDDNVDPNYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BVP1</accession>
    <name>A0A177BVP1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CC84DRAFT_1050998</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441561">
        <property type="protein sequence ID" value="OAF99553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029919.1">
        <property type="nucleotide sequence ID" value="XM_018173476.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BVP1"/>
    <dbReference type="GeneID" id="28756962"/>
    <dbReference type="InParanoid" id="A0A177BVP1"/>
    <dbReference type="OrthoDB" id="3944105at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF187">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="5"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAF99553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="60" mass="6769" checksum="3E34EF56FA08BB1E" modified="2016-09-07" version="1" fragment="single">RQRSYYLAIVMISYTVGMTAGRIVGGAVVDSGSWRWVFWLNVPIGDVALLVLFMYLHVGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BVV3</accession>
    <name>A0A177BVV3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_1209952</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441561">
        <property type="protein sequence ID" value="OAF99623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029989.1">
        <property type="nucleotide sequence ID" value="XM_018182253.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BVV3"/>
    <dbReference type="STRING" id="1460663.A0A177BVV3"/>
    <dbReference type="GeneID" id="28765739"/>
    <dbReference type="InParanoid" id="A0A177BVV3"/>
    <dbReference type="OrthoDB" id="2849579at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037381">
        <property type="entry name" value="RFWD3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16047:SF7">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RFWD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16047">
        <property type="entry name" value="RFWD3 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="3">
        <location>
            <begin position="292"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="223"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="223"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="266"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAF99623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="344" mass="38131" checksum="021A674783D8B216" modified="2016-09-07" version="1">MATPEVRGRPARASTTIHREPPSKIEISVIPVGTVQRLRNQVEARITPEVPVPDDVLLIRAQDHASALRQSRRTYKQRLRVAAEIGLFRMSPSLTRFIHDHDNMTRAVARSTELARRARNSSGVDTLTYVNICIIAVRNRLSRTWTITTFSSCAREALKATGTIGPAIETLRGMLEDVVVHILTLWDELSLRYLDENQLKNVGPDHNIDDFGHETTVGVAGEHRVNGPISDDKMGHAQSKGNTNSLPTPPPSPARIHISNGTLVDDNLDDNDDGDDDKEDDYSNSDDDSYHCSICTDPYTNRHRAFSLTRCGHIFGKACLSTWINSTARNANLCPHCRATISPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BWP7</accession>
    <name>A0A177BWP7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">tRNA pseudouridine synthase 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">tRNA pseudouridylate synthase 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">tRNA-uridine isomerase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CC84DRAFT_1104380</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Formation of pseudouridine at positions 27 and 28 in the anticodon stem and loop of transfer RNAs; at positions 34 and 36 of intron-containing precursor tRNA(Ile) and at position 35 in the intron-containing tRNA(Tyr). Catalyzes pseudouridylation at position 44 in U2 snRNA. Also catalyzes pseudouridylation of mRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a uridine in mRNA = a pseudouridine in mRNA</text>
            <dbReference type="Rhea" id="RHEA:56644"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:14659"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a uridine in tRNA = a pseudouridine in tRNA</text>
            <dbReference type="Rhea" id="RHEA:54572"/>
            <dbReference type="Rhea" id="RHEA-COMP:13339"/>
            <dbReference type="Rhea" id="RHEA-COMP:13934"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>uridine in snRNA = pseudouridine in snRNA</text>
            <dbReference type="Rhea" id="RHEA:51124"/>
            <dbReference type="Rhea" id="RHEA-COMP:12891"/>
            <dbReference type="Rhea" id="RHEA-COMP:12892"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the tRNA pseudouridine synthase TruA family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441562">
        <property type="protein sequence ID" value="OAF99380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029746.1">
        <property type="nucleotide sequence ID" value="XM_018175054.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BWP7"/>
    <dbReference type="FunCoup" id="A0A177BWP7">
        <property type="interactions" value="997"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177BWP7"/>
    <dbReference type="GeneID" id="28758540"/>
    <dbReference type="InParanoid" id="A0A177BWP7"/>
    <dbReference type="OrthoDB" id="10256309at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990481">
        <property type="term" value="P:mRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031120">
        <property type="term" value="P:snRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031119">
        <property type="term" value="P:tRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd02568">
        <property type="entry name" value="PseudoU_synth_PUS1_PUS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.580:FF:000002">
        <property type="entry name" value="tRNA pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.660:FF:000002">
        <property type="entry name" value="tRNA pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.660">
        <property type="entry name" value="Pseudouridine synthase I, catalytic domain, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.580">
        <property type="entry name" value="Pseudouridine synthase I, catalytic domain, N-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001406">
        <property type="entry name" value="PsdUridine_synth_TruA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020097">
        <property type="entry name" value="PsdUridine_synth_TruA_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020095">
        <property type="entry name" value="PsdUridine_synth_TruA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041708">
        <property type="entry name" value="PUS1/PUS2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020094">
        <property type="entry name" value="TruA/RsuA/RluB/E/F_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11142">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11142:SF4">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01416">
        <property type="entry name" value="PseudoU_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Pseudouridine synthase I TruA alpha/beta" evidence="17">
        <location>
            <begin position="418"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="314"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="42"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="56"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="328"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="14">
        <location>
            <position position="164"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00036943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00053072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00073968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00079072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00080858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR641708-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR641708-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF01416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="OAF99380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="623" mass="70791" checksum="DAC844B6DE6E19BB" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BXW9</accession>
    <name>A0A177BXW9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative isomerase YbhE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1074185</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cycloisomerase 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441560">
        <property type="protein sequence ID" value="OAF99975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030341.1">
        <property type="nucleotide sequence ID" value="XM_018173695.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BXW9"/>
    <dbReference type="STRING" id="1460663.A0A177BXW9"/>
    <dbReference type="GeneID" id="28757181"/>
    <dbReference type="InParanoid" id="A0A177BXW9"/>
    <dbReference type="OrthoDB" id="9972196at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017057">
        <property type="term" value="F:6-phosphogluconolactonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050282">
        <property type="entry name" value="Cycloisomerase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011048">
        <property type="entry name" value="Haem_d1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019405">
        <property type="entry name" value="Lactonase_7-beta_prop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30344:SF1">
        <property type="entry name" value="6-PHOSPHOGLUCONOLACTONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30344">
        <property type="entry name" value="6-PHOSPHOGLUCONOLACTONASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10282">
        <property type="entry name" value="Lactonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51004">
        <property type="entry name" value="C-terminal (heme d1) domain of cytochrome cd1-nitrite reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAF99975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="397" mass="42719" checksum="2EF49D662A32AF8F" modified="2016-09-07" version="1" fragment="single">LLGLSLLSQASAVKLLALNFAGQFYSLDLSFKSSTKASLKVVQNITACGVTPTWLHLDEETRTVYCIDESWLNEGLGSGNLSQWSVGPDFSKKDALTLTGSTDTEGNSVHGFTYGGPDGRSFLVTSEYSPSTVTTYKLPITSKTKALQKLEFTMAAPGPRPDRQDKPHPHAAFTDPTGDFLIVPDLGADLTRIFKINQKTGQLTACPAIASLPGDGPRHGLFRKAGRALKYYSLNEVSSSVGVYDVAYPDHSYGSKESCLSLKLVQTLSNYGPNVPLGNVTVKSAEIRVVGDFLYASNRNDTTFGFEQDSIAIFKIGGDGKLQFQELTNSHGYYPRSFSFNEAGTYAAIAGQTTANIAIVKRDTKTGKLGPLVTNLVLPPRGTYGGEDGVSNVIWVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BYG6</accession>
    <name>A0A177BYG6_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Class E vacuolar protein-sorting machinery protein HSE1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Class E vacuolar protein-sorting machinery protein hse1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CC84DRAFT_1190905</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the ESCRT-0 complex which is the sorting receptor for ubiquitinated cargo proteins at the multivesicular body (MVB).</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the ESCRT-0 complex composed of HSE1 and VPS27.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endosome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the STAM family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441560">
        <property type="protein sequence ID" value="OAG00186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030551.1">
        <property type="nucleotide sequence ID" value="XM_018181150.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BYG6"/>
    <dbReference type="FunCoup" id="A0A177BYG6">
        <property type="interactions" value="333"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177BYG6"/>
    <dbReference type="GeneID" id="28764636"/>
    <dbReference type="InParanoid" id="A0A177BYG6"/>
    <dbReference type="OrthoDB" id="10255964at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033565">
        <property type="term" value="C:ESCRT-0 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21386">
        <property type="entry name" value="GAT_Hse1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11805">
        <property type="entry name" value="SH3_GRB2_like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16978">
        <property type="entry name" value="VHS_HSE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000072">
        <property type="entry name" value="Unconventional Myosin IB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004152">
        <property type="entry name" value="GAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050670">
        <property type="entry name" value="STAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002014">
        <property type="entry name" value="VHS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45929">
        <property type="entry name" value="JAK PATHWAY SIGNAL TRANSDUCTION ADAPTOR MOLECULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45929:SF3">
        <property type="entry name" value="JAK PATHWAY SIGNAL TRANSDUCTION ADAPTOR MOLECULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03127">
        <property type="entry name" value="GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00790">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00288">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89009">
        <property type="entry name" value="GAT-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50179">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0967">Endosome</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 12" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="domain" description="VHS" evidence="15">
        <location>
            <begin position="16"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="14">
        <location>
            <begin position="216"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="138"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="176"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="394"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="183"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="422"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="442"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="509"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="522"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="539"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="573"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="601"/>
            <end position="612"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OAG00186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="619" mass="67330" checksum="2F631DE2167D3FAC" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BZ06</accession>
    <name>A0A177BZ06_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF6594 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_1231899</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441561">
        <property type="protein sequence ID" value="OAF99569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029935.1">
        <property type="nucleotide sequence ID" value="XM_018183743.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BZ06"/>
    <dbReference type="STRING" id="1460663.A0A177BZ06"/>
    <dbReference type="GeneID" id="28767229"/>
    <dbReference type="InParanoid" id="A0A177BZ06"/>
    <dbReference type="OrthoDB" id="3533814at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046529">
        <property type="entry name" value="DUF6594"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34502:SF3">
        <property type="entry name" value="DUF6594 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34502">
        <property type="entry name" value="DUF6594 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20237">
        <property type="entry name" value="DUF6594"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="312"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="365"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="393"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6594" evidence="3">
        <location>
            <begin position="102"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="42"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAF99569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="416" mass="46253" checksum="AF587A2DF5085258" modified="2016-09-07" version="1">MTGDTVLNDVEMGPQSPTDTERTIGGDAIIEIGEEDGASTIRSSSESSSRSSGYAVPAQPPQNEKQRPTFLRRVTGSFKSEPEPVGVTEIKTRQLDNTPNGFPRLAAFQASESNFSLYRSFTYLHSRVLLDLQDEITTLEKELDDIDWDDFDENPDRLRSREIDVAKAQDEGDTRNRRVILREIKAKLMEYDKVLIKARTLDSFQKPSDRNYRSVRRFHHNHKPLMDAETESIRSKEDTVSLRNSGREGGSFDGGLEKTIFKIDEWLKRIIKNFGVTDVHSPLGQYFQSPELRAKTTNKYITLYSSTRIDKLANILITLVIFALLVVPVVAMYLLTSTNVHTGTGSGLSSSSAVSPLDSNTRDTLNAVGLLIVFTLLFSAAMSLLTKAARHELFAASAAYCAILVVFIGNFTGPGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BZ48</accession>
    <name>A0A177BZ48_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein SQS1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_1191148</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441561">
        <property type="protein sequence ID" value="OAF99807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030173.1">
        <property type="nucleotide sequence ID" value="XM_018181164.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BZ48"/>
    <dbReference type="STRING" id="1460663.A0A177BZ48"/>
    <dbReference type="GeneID" id="28764650"/>
    <dbReference type="InParanoid" id="A0A177BZ48"/>
    <dbReference type="OrthoDB" id="21470at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00024">
        <property type="entry name" value="CD_CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.50">
        <property type="entry name" value="R3H-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001374">
        <property type="entry name" value="R3H_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036867">
        <property type="entry name" value="R3H_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051189">
        <property type="entry name" value="Splicing_assoc_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14195">
        <property type="entry name" value="G PATCH DOMAIN CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01424">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00443">
        <property type="entry name" value="G_patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00393">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82708">
        <property type="entry name" value="R3H domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51061">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="R3H" evidence="3">
        <location>
            <begin position="545"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="domain" description="G-patch" evidence="2">
        <location>
            <begin position="669"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="254"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="354"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="417"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="479"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="632"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="261"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="366"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="418"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAF99807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="712" mass="78752" checksum="11D0F1286F57829F" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BZJ0</accession>
    <name>A0A177BZJ0_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">FAD-binding FR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CC84DRAFT_1230736</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441559">
        <property type="protein sequence ID" value="OAG00576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030941.1">
        <property type="nucleotide sequence ID" value="XM_018183700.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BZJ0"/>
    <dbReference type="STRING" id="1460663.A0A177BZJ0"/>
    <dbReference type="GeneID" id="28767186"/>
    <dbReference type="InParanoid" id="A0A177BZJ0"/>
    <dbReference type="OrthoDB" id="3944240at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000293">
        <property type="term" value="F:ferric-chelate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015677">
        <property type="term" value="P:copper ion import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051410">
        <property type="entry name" value="Ferric/Cupric_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361:SF9">
        <property type="entry name" value="FERRIC REDUCTASE TRANSMEMBRANE COMPONENT 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361">
        <property type="entry name" value="FERRIC/CUPRIC REDUCTASE TRANSMEMBRANE COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="107"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="157"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="Ferric oxidoreductase" evidence="10">
        <location>
            <begin position="30"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="Ferric reductase NAD binding" evidence="11">
        <location>
            <begin position="296"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="403"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="412"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="436"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OAG00576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="582" mass="66438" checksum="092AFE985B3D3B0D" modified="2016-09-07" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BZL2</accession>
    <name>A0A177BZL2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Fe superoxide dismutase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1263391</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.</text>
    </comment>
    <dbReference type="EMBL" id="KV441559">
        <property type="protein sequence ID" value="OAG00421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030786.1">
        <property type="nucleotide sequence ID" value="XM_018185235.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BZL2"/>
    <dbReference type="FunCoup" id="A0A177BZL2">
        <property type="interactions" value="112"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177BZL2"/>
    <dbReference type="GeneID" id="28768721"/>
    <dbReference type="InParanoid" id="A0A177BZL2"/>
    <dbReference type="OrthoDB" id="275227at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004784">
        <property type="term" value="F:superoxide dismutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.55.40.20">
        <property type="entry name" value="Iron/manganese superoxide dismutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019832">
        <property type="entry name" value="Mn/Fe_SOD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036324">
        <property type="entry name" value="Mn/Fe_SOD_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036314">
        <property type="entry name" value="SOD_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43595">
        <property type="entry name" value="37S RIBOSOMAL PROTEIN S26, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43595:SF2">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02777">
        <property type="entry name" value="Sod_Fe_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54719">
        <property type="entry name" value="Fe,Mn superoxide dismutase (SOD), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46609">
        <property type="entry name" value="Fe,Mn superoxide dismutase (SOD), N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Manganese/iron superoxide dismutase C-terminal" evidence="2">
        <location>
            <begin position="128"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="Manganese/iron superoxide dismutase C-terminal" evidence="2">
        <location>
            <begin position="228"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG00421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="293" mass="32587" checksum="D71D04638C502000" modified="2016-09-07" version="1">MIIRSLTRRPGALQTLAQHASRAPYARRLHGVPSLLNHDELVNNGIPGLFSKKQFDIAYTQYQGHIVESLNIATAGSAYENRDPKSLIVDIARDPLMAYPWNLASMAFNNHFFFRGLNTNPNIASAPSADLVPLINRSFHSLETLQETMMLTADAMFGPGFVWLVQTPDAKDQPLKLLTTYIAGSPLSGAHNRKQPADMNTQNTESYAGSFGAAARQKENRPKKALGGVDVVPLLCVNTWEHVWLHDYGVAGKMSFLEKWWAKIDWAQVQQNVLFEKPQTQSAGGGFRQFYSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C0Q3</accession>
    <name>A0A177C0Q3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RanBP2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CC84DRAFT_1167595</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441557">
        <property type="protein sequence ID" value="OAG01374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031739.1">
        <property type="nucleotide sequence ID" value="XM_018179212.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C0Q3"/>
    <dbReference type="GeneID" id="28762698"/>
    <dbReference type="InParanoid" id="A0A177C0Q3"/>
    <dbReference type="OrthoDB" id="271448at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.380">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001876">
        <property type="entry name" value="Znf_RanBP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036443">
        <property type="entry name" value="Znf_RanBP2_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00547">
        <property type="entry name" value="ZnF_RBZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90209">
        <property type="entry name" value="Ran binding protein zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RanBP2-type" evidence="5">
        <location>
            <begin position="353"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="280"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="382"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="444"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="286"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="411"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="444"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="547"/>
            <end position="556"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAG01374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="635" mass="70177" checksum="19B6CDA4FA9A41E9" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C0Q6</accession>
    <name>A0A177C0Q6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DEAD/DEAH box helicase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CC84DRAFT_1101246</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441558">
        <property type="protein sequence ID" value="OAG00996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031361.1">
        <property type="nucleotide sequence ID" value="XM_018174904.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C0Q6"/>
    <dbReference type="FunCoup" id="A0A177C0Q6">
        <property type="interactions" value="15"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177C0Q6"/>
    <dbReference type="GeneID" id="28758390"/>
    <dbReference type="InParanoid" id="A0A177C0Q6"/>
    <dbReference type="OrthoDB" id="16911at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036121">
        <property type="term" value="F:double-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061749">
        <property type="term" value="F:forked DNA-dependent helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000403">
        <property type="term" value="F:Y-form DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032042">
        <property type="term" value="P:mitochondrial DNA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070125">
        <property type="term" value="P:mitochondrial translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18799">
        <property type="entry name" value="SF2_C_EcoAI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050742">
        <property type="entry name" value="Helicase_Restrict-Modif_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47396:SF1">
        <property type="entry name" value="ATP-DEPENDENT HELICASE IRC3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47396">
        <property type="entry name" value="TYPE I RESTRICTION ENZYME ECOKI R PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 5" id="KW-0347">Helicase</keyword>
    <keyword evidence="1 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="3">
        <location>
            <begin position="67"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="4">
        <location>
            <begin position="288"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="439"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="654"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="439"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="666"/>
            <end position="675"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAG00996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="675" mass="74725" checksum="67BA5A7F67CB69E2" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C0V9</accession>
    <name>A0A177C0V9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Condensin complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CC84DRAFT_1155315</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the CND2 (condensin subunit 2) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441559">
        <property type="protein sequence ID" value="OAG00472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030837.1">
        <property type="nucleotide sequence ID" value="XM_018176927.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C0V9"/>
    <dbReference type="FunCoup" id="A0A177C0V9">
        <property type="interactions" value="798"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177C0V9"/>
    <dbReference type="GeneID" id="28760413"/>
    <dbReference type="InParanoid" id="A0A177C0V9"/>
    <dbReference type="OrthoDB" id="362021at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061638">
        <property type="term" value="C:CENP-A containing chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000796">
        <property type="term" value="C:condensin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033553">
        <property type="term" value="C:rDNA heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051315">
        <property type="term" value="P:attachment of mitotic spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007076">
        <property type="term" value="P:mitotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022816">
        <property type="entry name" value="Condensin_barren_su2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13108">
        <property type="entry name" value="CONDENSIN COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13108:SF9">
        <property type="entry name" value="CONDENSIN COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05786">
        <property type="entry name" value="Cnd2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017126">
        <property type="entry name" value="Condensin_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7 11" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 11" id="KW-0226">DNA condensation</keyword>
    <keyword evidence="8 11" id="KW-0498">Mitosis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="169"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="268"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="350"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="427"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="182"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="291"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="427"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR017126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OAG00472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="793" mass="87301" checksum="534C04E3C7B1C82B" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C0Y3</accession>
    <name>A0A177C0Y3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Secretory component protein-like protein shr3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1102549</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441559">
        <property type="protein sequence ID" value="OAG00377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030742.1">
        <property type="nucleotide sequence ID" value="XM_018174971.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C0Y3"/>
    <dbReference type="FunCoup" id="A0A177C0Y3">
        <property type="interactions" value="64"/>
    </dbReference>
    <dbReference type="GeneID" id="28758457"/>
    <dbReference type="InParanoid" id="A0A177C0Y3"/>
    <dbReference type="OrthoDB" id="5229808at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013248">
        <property type="entry name" value="Psh3/Shr3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28228">
        <property type="entry name" value="SECRETORY COMPONENT PROTEIN SHR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28228:SF1">
        <property type="entry name" value="SECRETORY COMPONENT PROTEIN SHR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08229">
        <property type="entry name" value="SHR3_chaperone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029187">
        <property type="entry name" value="Shr3_AAP_chap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00786">
        <property type="entry name" value="SHR3_chaperone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG00377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="196" mass="21797" checksum="661E6F8735983ACA" modified="2016-09-07" version="1">MAAGTFGTFLIIGPVCFFLGILFSSFPYDYNVIWTTPEGPRDVYFNILEDHLKFLHASPPIISRILHIVIGTGLLGFLTKLYKASQANMLFDGASLVLYMAGITVYITNIVKGLRVVTAGIYGNVDPSEDENAEDYISREDTLRVFAASNTILALVLVGVLVLQAGQWYALRKEEAEIKEIEEKEQERKTAGKKKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C108</accession>
    <name>A0A177C108_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_1101582</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441558">
        <property type="protein sequence ID" value="OAG01175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031540.1">
        <property type="nucleotide sequence ID" value="XM_018174920.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C108"/>
    <dbReference type="STRING" id="1460663.A0A177C108"/>
    <dbReference type="GeneID" id="28758406"/>
    <dbReference type="InParanoid" id="A0A177C108"/>
    <dbReference type="OrthoDB" id="5778525at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052207">
        <property type="entry name" value="Max-like/E-box_TFs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15741">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX ZIP TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15741:SF39">
        <property type="entry name" value="BHLH TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="7">
        <location>
            <begin position="21"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="13"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAG01175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="114" mass="12804" checksum="397E490243668748" modified="2016-09-07" version="1">MTSSQSPPPGAADRPRLTEAQKKENHIRSEQKRREAIRDGFDRLASIVPGMEGQGRSEAVVLEATLQHMREKISERQKLIEAGKTKGMDTAGWELSRETVTACESQQKRNESEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C131</accession>
    <name>A0A177C131_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_187536</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441557">
        <property type="protein sequence ID" value="OAG01343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031708.1">
        <property type="nucleotide sequence ID" value="XM_018185518.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C131"/>
    <dbReference type="GeneID" id="28769004"/>
    <dbReference type="InParanoid" id="A0A177C131"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG01343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="81" mass="8919" checksum="3E72BDEA7CD40962" modified="2016-09-07" version="1">MIPGVSTCISSAPILSMFASGMVVIVALQYAPDKVTIVEEPELWILCKDTLHDNGIMRLIHVVVVISERIYNGSRSFTRQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2023-06-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C148</accession>
    <name>A0A177C148_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1179454</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441557">
        <property type="protein sequence ID" value="OAG01363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031728.1">
        <property type="nucleotide sequence ID" value="XM_018180417.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C148"/>
    <dbReference type="GeneID" id="28763903"/>
    <dbReference type="InParanoid" id="A0A177C148"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG01363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="157" mass="17662" checksum="A95157130C7EF396" modified="2016-09-07" version="1">MTEAEKPDHINSANIKISPKYGLEKGAPETDCEIPSARRIGQRPRLCLRNGNDGFAPINADKTAYTIDGLGGLPSYPGRWIHVKMADDLAEGKNTARVRMDATFFISIEKRYDSFNPYPCFQFALPIIGVSRRSFMLAHLDPWEVFKRLQSQQSSTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C1C9</accession>
    <name>A0A177C1C9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Sugar transporter STL1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CC84DRAFT_1153534</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441557">
        <property type="protein sequence ID" value="OAG01594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031959.1">
        <property type="nucleotide sequence ID" value="XM_018176842.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C1C9"/>
    <dbReference type="GeneID" id="28760328"/>
    <dbReference type="InParanoid" id="A0A177C1C9"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000061">
        <property type="entry name" value="MFS sugar transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF68">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="72"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="157"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="186"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="342"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="369"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="406"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="439"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="16"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAG01594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="544" mass="60504" checksum="17960134C77FEA92" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C1Y3</accession>
    <name>A0A177C1Y3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LAlv9 family protein-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_271328</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AVL9 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441558">
        <property type="protein sequence ID" value="OAG00899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031264.1">
        <property type="nucleotide sequence ID" value="XM_018185683.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C1Y3"/>
    <dbReference type="FunCoup" id="A0A177C1Y3">
        <property type="interactions" value="237"/>
    </dbReference>
    <dbReference type="GeneID" id="28769169"/>
    <dbReference type="InParanoid" id="A0A177C1Y3"/>
    <dbReference type="OrthoDB" id="26278at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11500">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018307">
        <property type="entry name" value="ABL9/DENND6_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043153">
        <property type="entry name" value="DENN_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051731">
        <property type="entry name" value="DENND11/AVL9_GEFs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037516">
        <property type="entry name" value="Tripartite_DENN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31017:SF1">
        <property type="entry name" value="LATE SECRETORY PATHWAY PROTEIN AVL9 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31017">
        <property type="entry name" value="LATE SECRETORY PATHWAY PROTEIN AVL9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09794">
        <property type="entry name" value="Avl9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50211">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDENN" evidence="2">
        <location>
            <begin position="5"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG00899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="458" mass="52186" checksum="0AE79F70B1BBA511" modified="2016-09-07" version="1">MAFAPLICVVDFHHARGPEVERWFGVEEGSADPSVENDWVNLPFMALSDGAHASTEDYSYFTLRRAETPKHPASSLFGISCTRQLDASKLIDRPAEVTRSTVQKAVVVVSDSPQYFGAIKAQLGVVTAAWFAQRDFTDVEILQRFSESLPTLLKNQEGEPDHYFGISLREMIHEFKWQTLVLFKCALLQPKMLFFGSHCERLCMMQFALISLIPGLIRHLQDSADPKFNSCETELVMPTSLKTSQRSSLLTYMGLPLQLFGRGSLFGPYTPLQQLDVLADQDTKSYIVGSTNSLLLQQRDRYSDILINLDEHTVNITSSSLQHALTLSTPDRRWIDFLTQTVHDTWDESNPSRPKDHGYAGSEEFIRMQFEEYLLAMLSAVKFKAYQEKNKDKERIITEHEGDPAGEFSNNYIHAWMQTENFRIWNKFTDSHLFDIVEPKHPCSGGLSIEDVQRRLAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C239</accession>
    <name>A0A177C239_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_280491</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441558">
        <property type="protein sequence ID" value="OAG01221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031586.1">
        <property type="nucleotide sequence ID" value="XM_018185748.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C239"/>
    <dbReference type="GeneID" id="28769234"/>
    <dbReference type="InParanoid" id="A0A177C239"/>
    <dbReference type="OrthoDB" id="630895at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051531">
        <property type="entry name" value="N-acetyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43792">
        <property type="entry name" value="GNAT FAMILY, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G00765)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43792:SF1">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="142"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG01221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="234" mass="26270" checksum="AF0ADC16233C23C3" modified="2016-09-07" version="1">MSPQTKEVLETERLRLIRISDTSLDGDHVKWFHTTWSDPVATSWSLHGKTNTVEESQAWFTEHLEKFDTILYMVFVRFSADGAELPFPGEVIGNVGLRTQADGASLPPFSRACAAPVSDQAPTDPSKPPLSDLEVEKPLNLRSIGYSFLQKAWGKGYATEAARAVLEAYREGTREVREKGDEVYYVEAIWGDGNPASGRVLGKLGFREIGYRKEEKVWLAGDWRSGYYVSGWYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C2B9</accession>
    <name>A0A177C2B9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Spt20-like SEP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_1208693</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441557">
        <property type="protein sequence ID" value="OAG01585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031950.1">
        <property type="nucleotide sequence ID" value="XM_018182173.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C2B9"/>
    <dbReference type="STRING" id="1460663.A0A177C2B9"/>
    <dbReference type="GeneID" id="28765659"/>
    <dbReference type="InParanoid" id="A0A177C2B9"/>
    <dbReference type="OrthoDB" id="1932706at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046468">
        <property type="entry name" value="Spt20-like_SEP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12090">
        <property type="entry name" value="Spt20_SEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Spt20-like SEP" evidence="3">
        <location>
            <begin position="57"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="174"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="247"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="364"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="403"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="561"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="807"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="766"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="185"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="256"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="403"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="417"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="430"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="561"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="808"/>
            <end position="819"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAG01585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="894" mass="99004" checksum="FCA533DC17543780" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C2P3</accession>
    <name>A0A177C2P3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CC84DRAFT_1154561</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441558">
        <property type="protein sequence ID" value="OAG01088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031453.1">
        <property type="nucleotide sequence ID" value="XM_018176897.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C2P3"/>
    <dbReference type="STRING" id="1460663.A0A177C2P3"/>
    <dbReference type="GeneID" id="28760383"/>
    <dbReference type="InParanoid" id="A0A177C2P3"/>
    <dbReference type="OrthoDB" id="3014581at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF90">
        <property type="entry name" value="CENTROMERE DNA-BINDING PROTEIN COMPLEX CBF3 SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="17"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAG01088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="726" mass="81151" checksum="3F4FF55684BE87CA" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C2T3</accession>
    <name>A0A177C2T3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Zinc metallo protein-like proteinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_216457</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441557">
        <property type="protein sequence ID" value="OAG01746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032111.1">
        <property type="nucleotide sequence ID" value="XM_018185614.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C2T3"/>
    <dbReference type="STRING" id="1460663.A0A177C2T3"/>
    <dbReference type="GeneID" id="28769100"/>
    <dbReference type="InParanoid" id="A0A177C2T3"/>
    <dbReference type="OrthoDB" id="49605at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013536">
        <property type="entry name" value="WLM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47795:SF1">
        <property type="entry name" value="DNA-DEPENDENT METALLOPROTEASE WSS1 HOMOLOG 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47795">
        <property type="entry name" value="UBIQUITIN AND WLM DOMAIN-CONTAINING METALLOPROTEASE SPCC1442.07C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08325">
        <property type="entry name" value="WLM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51397">
        <property type="entry name" value="WLM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WLM" evidence="2">
        <location>
            <begin position="121"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="316"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="316"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG01746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="342" mass="37731" checksum="33501610F3F3729D" modified="2016-09-07" version="1">MDTSTPADDITLTLTHHGSPITFTFAQDATVADLSERVASELSIPALNQKFLVSPKTGLLKPPFKDATLPLSSLQGKKINLMGSTIAEVTSLNDSISKAAAPRRPGPIKAATPARNRDWKKVQEEAQYTFHTLRPLPYLPNPDRSLRFLERLRDDAGIKAAMRTHKFSVPLLTEMDPAMHTTHESRTLGLNRNQGEVIELRLRTDAYDGYRDYKTIRKTLCHELAHNVWGPHDRNFWELCKQIEREVDRDDWTRGGHSVGNQEYAEGYEEEVYDHGGWTGGEFVLGGSAGGGGGETVVNSAGGTVQAGNLSRREILAKAAEERMKRARQAEEGSRGSGEAPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C2Y6</accession>
    <name>A0A177C2Y6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Extradiol aromatic ring-opening dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CC84DRAFT_1167534</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DODA-type extradiol aromatic ring-opening dioxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441557">
        <property type="protein sequence ID" value="OAG01279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031644.1">
        <property type="nucleotide sequence ID" value="XM_018179196.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C2Y6"/>
    <dbReference type="STRING" id="1460663.A0A177C2Y6"/>
    <dbReference type="GeneID" id="28762682"/>
    <dbReference type="InParanoid" id="A0A177C2Y6"/>
    <dbReference type="OrthoDB" id="7396853at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016702">
        <property type="term" value="F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07363">
        <property type="entry name" value="45_DOPA_Dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.830.10">
        <property type="entry name" value="LigB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014436">
        <property type="entry name" value="Extradiol_dOase_DODA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004183">
        <property type="entry name" value="Xdiol_dOase_suB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30096">
        <property type="entry name" value="4,5-DOPA DIOXYGENASE EXTRADIOL-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30096:SF0">
        <property type="entry name" value="4,5-DOPA DIOXYGENASE EXTRADIOL-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02900">
        <property type="entry name" value="LigB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006157">
        <property type="entry name" value="Doxgns_DODA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53213">
        <property type="entry name" value="LigB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Extradiol ring-cleavage dioxygenase class III enzyme subunit B" evidence="6">
        <location>
            <begin position="23"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAG01279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="281" mass="30627" checksum="1F9904C46F9530FD" modified="2016-09-07" version="1">MTRRAPVISISHGGGPMPLLGDPSQAALTHSMKTKVPKILKLGTADAPRAIILVTAHWSEDVVGISSAEKHELYYDYYGFPDEAYKLKYDAPGSPEVAELVRRQLEEAGIKSKNDGKRGWDHGVFVPMTLIHPSASVPIIQLSVLASEDPSMHYAIGRALAPLRDKNIAIIGSGFASMHNLRAMFSGQARTPSYKALNEAWSKTVADAVETTDVEAQKEKFAGWRSWPGAYDMHPRGGAEHFLPLVVCAGAGAGEKSKAYGDEMVGLQMWSYYWDGEEAQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C540</accession>
    <name>A0A177C540_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">3-alpha--hydroxysteroid dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CC84DRAFT_1152601</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441556">
        <property type="protein sequence ID" value="OAG02271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032636.1">
        <property type="nucleotide sequence ID" value="XM_018176809.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C540"/>
    <dbReference type="STRING" id="1460663.A0A177C540"/>
    <dbReference type="GeneID" id="28760295"/>
    <dbReference type="InParanoid" id="A0A177C540"/>
    <dbReference type="OrthoDB" id="1669814at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24321">
        <property type="entry name" value="DEHYDROGENASES, SHORT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24321:SF8">
        <property type="entry name" value="ESTRADIOL 17-BETA-DEHYDROGENASE 8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoreductase" evidence="5">
        <location>
            <begin position="6"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAG02271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="249" mass="26240" checksum="0115F15EDF1F85F1" modified="2016-09-07" version="1">MSIKGKVIVITGAASGMGLETARLFASKGAKLSLADVQEKPLKDLMAELQSAGAEVMATVVDVSNRKSVDDWIAATVSKFGKLDGAANLAGVIGRQNNIAGVAELDDDDWDFVMNINTKGLMFCLRAQAPVMNEGGSIVNAASILGLIGAAKSMPYVASKHAVVGMTRSAAKELGARNIRVNCFCPGPIDTPMFQKSLEIRGTKMNTDFLALKRTADPKEVPPLLEFLISDASSFITGAAMPIDGGWFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C583</accession>
    <name>A0A177C583_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_981934</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441556">
        <property type="protein sequence ID" value="OAG02052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032417.1">
        <property type="nucleotide sequence ID" value="XM_018188044.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C583"/>
    <dbReference type="GeneID" id="28771530"/>
    <dbReference type="InParanoid" id="A0A177C583"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG02052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="88" mass="9735" checksum="C4B3A53DA9E788F5" modified="2016-09-07" version="1">MRSVEIYRRATAFQSGYTIITIAIRQDTITRNQKAASVVILAFLPALLSTTLANTEPLSFADAVPAYPCSAQELWLSTSRLRRSCCSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C5X9</accession>
    <name>A0A177C5X9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1250902</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG02925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033290.1">
        <property type="nucleotide sequence ID" value="XM_018184316.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C5X9"/>
    <dbReference type="GeneID" id="28767802"/>
    <dbReference type="InParanoid" id="A0A177C5X9"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG02925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="148" mass="16763" checksum="DD12AC8B5C6BC6E7" modified="2016-09-07" version="1">MENPGTRKCVSCYLSKAAGNYLRSICNTCFESGMTCDYDFQRHIPQNVYEGNLNPTDYSSAWAWREAKSDEKNRASRALLDEGEDNEDDEDDDGDVGITEITQSMQSTSLSASGGPYRRRRIVPHIGESMANPKRRVIYSNRKEMDAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C6E5</accession>
    <name>A0A177C6E5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Inosine monophosphate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CC84DRAFT_1253253</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441556">
        <property type="protein sequence ID" value="OAG02449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032814.1">
        <property type="nucleotide sequence ID" value="XM_018184386.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C6E5"/>
    <dbReference type="STRING" id="1460663.A0A177C6E5"/>
    <dbReference type="GeneID" id="28767872"/>
    <dbReference type="InParanoid" id="A0A177C6E5"/>
    <dbReference type="OrthoDB" id="2349068at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018580">
        <property type="term" value="F:nitronate monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04730">
        <property type="entry name" value="NPD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004136">
        <property type="entry name" value="NMO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32332">
        <property type="entry name" value="2-NITROPROPANE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32332:SF34">
        <property type="entry name" value="2-NITROPROPANE DIOXYGENASE FAMILY, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03060">
        <property type="entry name" value="NMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51412">
        <property type="entry name" value="Inosine monophosphate dehydrogenase (IMPDH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="20"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAG02449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="355" mass="37161" checksum="01E6E44DF885A431" modified="2016-09-07" version="1">MPSQQWSHTLSSYLPWTSPPLLISAPMGGFAWAPLATAVSLAGGLGLIGSLNDMSQLRTQLAEARSTFAASSNAAIKDSPTLPLGVGILAFICKIEDVVPVIREFEPAVVWLFAAKQLDDYTAWVDALREASPTSKVWIQVGNVEAALHVAKDARPDAICLQGADAGGHGFEKAAGIISLVPEAADALRREGHGDIPLLASGGIVDGRGVAAALALGAAGVVMGTRFLASKEVAIHPIAQAAVLEAQDGGQATRRSKLFDQLRGPNVWPEAYDGRSLVVQSYQDHVDGVGLEEIQRLHNEAVLGEDKGYATGRKGRAAIWAGTGVGSVGKVEEAGNIVEKVKREAREVMGGLAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C779</accession>
    <name>A0A177C779_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">YVTN repeat-like/Quino protein amine dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1207969</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG03266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033631.1">
        <property type="nucleotide sequence ID" value="XM_018182132.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C779"/>
    <dbReference type="STRING" id="1460663.A0A177C779"/>
    <dbReference type="GeneID" id="28765618"/>
    <dbReference type="InParanoid" id="A0A177C779"/>
    <dbReference type="OrthoDB" id="1367865at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008057836" evidence="1">
        <location>
            <begin position="20"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG03266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="451" mass="50139" checksum="C5A4DBC6CF18BBF3" modified="2016-09-07" version="1">MATLKLLIVTAGILRAAHSAVLPGFKTVLVNNVIVPKTKSDFTKNNVPAKWASGHPKEWGTEDFHYRLNAQDPDDNFGAVVTGDERYLVMYNGSYVEFVDLEKNITASGFAFQIPDKQYATDLTVRPATKGGYDVFTGVAPYKYDTTRTIIRQRVGSDVKPIDQPILYQGSIGDISNQGKLASTSGYIYDLETTSNSPVATLEGQPATSDLSFSPDGVHLSSVDWQAQTADLWNATSGEKIFSFPATNAQNWVTRFSPDGKYVAITLGSGNRTLQIYAMSDLTAAPIEIKDFNDWPRQLAWSPNSKEIAAGDDGRLRIFNVPSKEVIQTWQIDTNEFYPPAGIKWHNDGNKISWQWNNGKYLYDFETNTEYLWTVSITDHVWGPEGFYLAGKQGIATVDGDSTHALSIYYQIVTITLLRDPHQHNRKSDTPAALGLTSFFVSISHMESRFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C8S4</accession>
    <name>A0A177C8S4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1166902</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG03157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033522.1">
        <property type="nucleotide sequence ID" value="XM_018179078.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C8S4"/>
    <dbReference type="GeneID" id="28762564"/>
    <dbReference type="InParanoid" id="A0A177C8S4"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG03157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="153" mass="16531" checksum="F6FB3F8DDFF10322" modified="2016-09-07" version="1">MQDRSNHQQRISICRFHGPPNSGAKINSQATSYHPPQRQNSHFPLVHNPPSPSRSNSAQLTRHTSKNPVQSAPPRPVALHQAANSRPPTAPPRAPLAKLPRATCVTVQPRPLHPGRARARLPISAVLTDRSGRGTRCRKEGVSGLEEGIGGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C9I5</accession>
    <name>A0A177C9I5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1219438</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG04235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034600.1">
        <property type="nucleotide sequence ID" value="XM_018183082.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C9I5"/>
    <dbReference type="GeneID" id="28766568"/>
    <dbReference type="InParanoid" id="A0A177C9I5"/>
    <dbReference type="OrthoDB" id="3755781at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="506"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="431"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="231"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="244"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="298"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="319"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="347"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="468"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG04235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="587" mass="64510" checksum="EF2020AF0A005C6D" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C9J3</accession>
    <name>A0A177C9J3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FYVE-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CC84DRAFT_866660</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG03791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034156.1">
        <property type="nucleotide sequence ID" value="XM_018187714.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C9J3"/>
    <dbReference type="STRING" id="1460663.A0A177C9J3"/>
    <dbReference type="GeneID" id="28771200"/>
    <dbReference type="InParanoid" id="A0A177C9J3"/>
    <dbReference type="OrthoDB" id="10018316at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15760">
        <property type="entry name" value="FYVE_scVPS27p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052113">
        <property type="entry name" value="FYVE-type_Zinc_Finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39490">
        <property type="entry name" value="ARRESTIN DOMAIN-CONTAINING PROTEIN D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39490:SF8">
        <property type="entry name" value="ZINC FINGER FYVE DOMAIN-CONTAINING PROTEIN 21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FYVE-type" evidence="6">
        <location>
            <begin position="155"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="75"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAG03791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="268" mass="29484" checksum="496CC4A075C08A66" modified="2016-09-07" version="1">MSTQFSGTAVAVQHNPFQHAYKKSALYSQMDSGSNTPMNVSPTSPRTMGHLPAYPQHAPALRPLKTPGYIPAALRRTEKPGGRSPPTADSASDTPNTTWGSSGQSPGEITPISRIATEDMRSIYDDTPLSPVAGPITRNHWQPDSSTVVCTASCCQQPFGLFMRRHHCRKCGGIFCYQHIQKQVRLNEHALFHPEGELHKACDRCHTQFREWEQMRSSRTNSESSGSIDSPAAVQIEQAPQAKRPECAPKASFLSQSFGGGTWNWSTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C9M4</accession>
    <name>A0A177C9M4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Transcription factor TFIIIC triple barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1095036</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG03552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033917.1">
        <property type="nucleotide sequence ID" value="XM_018174594.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C9M4"/>
    <dbReference type="STRING" id="1460663.A0A177C9M4"/>
    <dbReference type="GeneID" id="28758080"/>
    <dbReference type="InParanoid" id="A0A177C9M4"/>
    <dbReference type="OrthoDB" id="1877767at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.4370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019481">
        <property type="entry name" value="TFIIIC_triple_barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10419">
        <property type="entry name" value="TFIIIC_sub6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription factor TFIIIC triple barrel" evidence="2">
        <location>
            <begin position="16"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="214"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG03552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="246" mass="26361" checksum="C9FC6D29C9030198" modified="2016-09-07" version="1">MAAVEDDEWEYEYDDNETEDFYIPIDLANVPSVQGALGLGGSTQRGHPTLLATKLRAITSERRDAESSLVVQNVEDVGESVGKIQIIGLHTENPLMMYNDQLLSCEWNKTIGTDLIFAKPGAIVEKEGKALRSLPSVDLVAMGSAKLVARVARMRPRDDLFDEDPKIGDQSSAEAMDTSGAVEPVVQTTRPASSSFLGQLNALKARRGEASRLALSDAPGGPRLVAAEESASNADTANEDITMSGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C9M8</accession>
    <name>A0A177C9M8_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">Arginase</fullName>
            <ecNumber evidence="2 11">3.5.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CC84DRAFT_1165709</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 11">
            <text>L-arginine + H2O = urea + L-ornithine</text>
            <dbReference type="Rhea" id="RHEA:20569"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16199"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="EC" id="3.5.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="11">Binds 2 manganese ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Nitrogen metabolism; urea cycle; L-ornithine and urea from L-arginine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9 10">Belongs to the arginase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.3.1" evidence="2 11"/>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG03478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033843.1">
        <property type="nucleotide sequence ID" value="XM_018178781.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C9M8"/>
    <dbReference type="FunCoup" id="A0A177C9M8">
        <property type="interactions" value="1325"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177C9M8"/>
    <dbReference type="GeneID" id="28762267"/>
    <dbReference type="InParanoid" id="A0A177C9M8"/>
    <dbReference type="OrthoDB" id="9992747at2759"/>
    <dbReference type="UniPathway" id="UPA00158">
        <property type="reaction ID" value="UER00270"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004053">
        <property type="term" value="F:arginase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006525">
        <property type="term" value="P:arginine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000050">
        <property type="term" value="P:urea cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd09989">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.800.10:FF:000009">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.10">
        <property type="entry name" value="Ureohydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014033">
        <property type="entry name" value="Arginase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006035">
        <property type="entry name" value="Ureohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020855">
        <property type="entry name" value="Ureohydrolase_Mn_BS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01229">
        <property type="entry name" value="rocF_arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43782">
        <property type="entry name" value="ARGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43782:SF3">
        <property type="entry name" value="ARGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00491">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00116">
        <property type="entry name" value="ARGINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01053">
        <property type="entry name" value="ARGINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51409">
        <property type="entry name" value="ARGINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0056">Arginine metabolism</keyword>
    <keyword evidence="6 10 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 11" id="KW-0464">Manganese</keyword>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OAG03478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="324" mass="35084" checksum="5C36465FF87C01CB" modified="2016-09-07" version="1">MTSAPQIQPKFLPNRHDLGVVAVGFSGGQPKAGVDAAPQALIQHGLIQQLEDELEFKVSFDGEVHDYSKFMPAEDPDYRGMKKPKFVSATTQAVSEQVYNHAKSGKLVLTLGGDHSIAIGTVSGTARAIRERLDKEIAVIWVDAHADINTPETSDSGNIHGMPVAFLTGLAKEEREDTFGWLKEHHRLSTKKIVYIGLRDVDRGEKKILKEHGIKAFSMHDIDRHGIGKVMDMALGWIGSDTPIHLSFDVDALDPMWAPSTGTPVRGGLTLREGDFIAECVAETGSLVALDLVEVNPSLDEQGASDTVRAGCSIVRCALGDTLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C9P1</accession>
    <name>A0A177C9P1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1206141</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG04464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034829.1">
        <property type="nucleotide sequence ID" value="XM_018182018.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C9P1"/>
    <dbReference type="GeneID" id="28765504"/>
    <dbReference type="InParanoid" id="A0A177C9P1"/>
    <dbReference type="OrthoDB" id="3711359at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG04464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="348" mass="40053" checksum="39BD2190BB642167" modified="2016-09-07" version="1">MAFQPRYYTQPSFFEHLNYDVRQIIYQFMEHHLPPISQSLKYAGFPLSCKQAYIESRLPAIKGVRRFLEDFQRNFDRYTSEPTRIIPDIPLDSTFASLRHITLRIPASLVTSAFDNQLDKAVVALRPVLSAHFQKVTLLFVDPQNEYPANFKTAMRVSSGYALFRLSQIIMDERKVQSSISALSKYVSDLSGYETVHPTSHAQPYPSDFTGTLLYKGNDLPHPISTTDIQIAWDWRKESLIGTPSTLRGYHHEYSAQAERHDGSTWPQLYVVENDEKSVGMQGIVCRQRWNVSESVRVYWLLQEHRYKSLRGFCWSEGVGEDVQQGLGGMSDEEFQERNPPLVLAALF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C9U2</accession>
    <name>A0A177C9U2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_852697</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG03490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033855.1">
        <property type="nucleotide sequence ID" value="XM_018187629.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C9U2"/>
    <dbReference type="GeneID" id="28771115"/>
    <dbReference type="InParanoid" id="A0A177C9U2"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG03490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="218" mass="24773" checksum="763D87FEACB7350C" modified="2016-09-07" version="1">MVFYSYRCMLGLVSQLTTLFFISQLHSPLRPTRKHWLLLHTIRSSSLHHHLAKAPSSSTMSPREVEHSTPLLKLLQNYNRTRSTRIPGNLPRPAQIPRLCLPPLNPPPFNVSQHLLQGPQLSSSTTHASSKLQTRLHSAPASKPTPRKRTPVQIALERAAIQGYHLGTPDKRIAVLEREVRCLREAMKRPKQSVGVWGKKREKASVGKRGHVRAWRDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C9U3</accession>
    <name>A0A177C9U3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Bacteriophage T5 Orf172 DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1177547</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG03548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033913.1">
        <property type="nucleotide sequence ID" value="XM_018180289.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C9U3"/>
    <dbReference type="STRING" id="1460663.A0A177C9U3"/>
    <dbReference type="GeneID" id="28763775"/>
    <dbReference type="InParanoid" id="A0A177C9U3"/>
    <dbReference type="OrthoDB" id="3511049at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018306">
        <property type="entry name" value="Phage_T5_Orf172_DNA-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10544">
        <property type="entry name" value="T5orf172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00974">
        <property type="entry name" value="T5orf172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bacteriophage T5 Orf172 DNA-binding" evidence="2">
        <location>
            <begin position="572"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="206"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="382"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="382"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="436"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="485"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG03548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="914" mass="102051" checksum="B3DE7D4FB7748B18" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C9Z1</accession>
    <name>A0A177C9Z1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Periplasmic binding protein-like II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_862334</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG03649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034014.1">
        <property type="nucleotide sequence ID" value="XM_018187674.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C9Z1"/>
    <dbReference type="STRING" id="1460663.A0A177C9Z1"/>
    <dbReference type="GeneID" id="28771160"/>
    <dbReference type="InParanoid" id="A0A177C9Z1"/>
    <dbReference type="OrthoDB" id="5194099at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015168">
        <property type="entry name" value="SsuA/THI5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30024">
        <property type="entry name" value="ALIPHATIC SULFONATES-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30024:SF42">
        <property type="entry name" value="ALIPHATIC SULFONATES-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09084">
        <property type="entry name" value="NMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008057924" evidence="1">
        <location>
            <begin position="19"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="SsuA/THI5-like" evidence="2">
        <location>
            <begin position="55"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG03649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="314" mass="33969" checksum="AAA176593E92A70D" modified="2016-09-07" version="1">MYLTHLLLPFALLPNISALKIATSLQWIEHTPQAYAIKNFYKGSSPATLSSGGVANLASDSSIDLAANAETQGLKQYANHKSLRLIYIITEVSYRLVARSSSPANVKSLADLKGKKIGSMPGTSAAIFVQRMLASAGVNDGAYSIVSGNVCMKAPCGSGTLPAMLKGGQVDAFGIWEPAVELGIRAIGKDNAVVFQNATTYREVYSLYTTTDKLADPKKRADIVAFVRALNQTLEVYNHPNASVYSFVADRVGMDAEVVEAVWADHKWSGTWKDEELMPLLVDEDAMLAKSDRRAPMSRAELETFLDTSVIEAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CAE3</accession>
    <name>A0A177CAE3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glycoside hydrolase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1188309</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG03690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034055.1">
        <property type="nucleotide sequence ID" value="XM_018180981.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CAE3"/>
    <dbReference type="STRING" id="1460663.A0A177CAE3"/>
    <dbReference type="GeneID" id="28764467"/>
    <dbReference type="InParanoid" id="A0A177CAE3"/>
    <dbReference type="OrthoDB" id="3257981at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051118">
        <property type="term" value="F:glucan endo-1,3-alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11577">
        <property type="entry name" value="GH71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005197">
        <property type="entry name" value="Glyco_hydro_71"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03659">
        <property type="entry name" value="Glyco_hydro_71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG03690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="387" mass="42175" checksum="6D22D67747BA10AB" modified="2016-09-07" version="1">MDLGLDAFALNINSLQSWATETVERLFKNADDLGFKLFFSFDFGPNNFGDPSEVVDYLKPFLSRPSYYAHNGKQLVTTFGGEQFDDGKISQFKSNVGGNVLFIPGLYNGAASADIFSKNPSYDGVFGWNSWPSSFAGNVETTAETTDDAVWAQAVSNSPGKLRIAGLSPINFKHYAGQNWYRRGEQNLEVRMAALLKDQPDMIEIQTWNDAPESHYIGNIWDEPNTGNTEAQGWYKGFDHTGYQQVIKAFAKAWHTCDSVENMVPTNGKSVQGAFWHHVLTVGGDCSADPKGKPDPLPAEDSVSGVVLVAKGSAGLVAVVNNGDKELGKLTLKEGYNSFKFDNLGAGKVQLEVWDGSTMVGGGYSNQTVQTSSDICNYNFQVVGFPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CC12</accession>
    <name>A0A177CC12_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cloroperoxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CC84DRAFT_1246376</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the chloroperoxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG04412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034777.1">
        <property type="nucleotide sequence ID" value="XM_018184200.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CC12"/>
    <dbReference type="STRING" id="1460663.A0A177CC12"/>
    <dbReference type="GeneID" id="28767686"/>
    <dbReference type="InParanoid" id="A0A177CC12"/>
    <dbReference type="OrthoDB" id="407298at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.489.10">
        <property type="entry name" value="Chloroperoxidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000028">
        <property type="entry name" value="Chloroperoxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036851">
        <property type="entry name" value="Chloroperoxidase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33577:SF18">
        <property type="entry name" value="HEME HALOPEROXIDASE FAMILY PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33577">
        <property type="entry name" value="STERIGMATOCYSTIN BIOSYNTHESIS PEROXIDASE STCC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01328">
        <property type="entry name" value="Peroxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47571">
        <property type="entry name" value="Cloroperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51405">
        <property type="entry name" value="HEME_HALOPEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 10" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="Heme haloperoxidase family profile" evidence="9">
        <location>
            <begin position="49"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAG04412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="288" mass="32007" checksum="1FD68647B3BF118B" modified="2016-09-07" version="1">MSLVKKASKPFILLFVLAWDLGLFILNVVIPKRKVGHVVPVGAPGHARNWPAYEAPKPGDSRSSCPMLNALANHNILPHSGRDIPFRTLNTAIRECFNFAPSFCFFVPHFAADFLNRSYWSGTLDLEELSLHNAIEHDASLTRRDVALEPDQAKPDILLVEQLLAGATGGTPEARLLTKQDLSAALTRRRVESKRENASYTESLFHKGFGSANSSTMLTIFGGRINDLRPMLLEERFPDDWEPRIRSHFGLTMAAFNGTVLPVERGVDTRAYVKKLEGEDAEPTEASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CD94</accession>
    <name>A0A177CD94_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Vacuolar protein sorting-associated protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CC84DRAFT_1165219</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG04842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035207.1">
        <property type="nucleotide sequence ID" value="XM_018178668.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CD94"/>
    <dbReference type="FunCoup" id="A0A177CD94">
        <property type="interactions" value="386"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CD94"/>
    <dbReference type="GeneID" id="28762154"/>
    <dbReference type="InParanoid" id="A0A177CD94"/>
    <dbReference type="OrthoDB" id="5061070at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048312">
        <property type="term" value="P:intracellular distribution of mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000266">
        <property type="term" value="P:mitochondrial fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016559">
        <property type="term" value="P:peroxisome fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007033">
        <property type="term" value="P:vacuole organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd08771">
        <property type="entry name" value="DLP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000473">
        <property type="entry name" value="Vacuolar sorting-associated 1 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1240">
        <property type="entry name" value="Dynamin, middle domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022812">
        <property type="entry name" value="Dynamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001401">
        <property type="entry name" value="Dynamin_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019762">
        <property type="entry name" value="Dynamin_GTPase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000375">
        <property type="entry name" value="Dynamin_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030381">
        <property type="entry name" value="G_DYNAMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003130">
        <property type="entry name" value="GED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020850">
        <property type="entry name" value="GED_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566">
        <property type="entry name" value="DYNAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566:SF220">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01031">
        <property type="entry name" value="Dynamin_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02212">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00195">
        <property type="entry name" value="DYNAMIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00053">
        <property type="entry name" value="DYNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00302">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00410">
        <property type="entry name" value="G_DYNAMIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51718">
        <property type="entry name" value="G_DYNAMIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51388">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0505">Motor protein</keyword>
    <keyword evidence="1 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynamin-type G" evidence="8">
        <location>
            <begin position="34"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="GED" evidence="7">
        <location>
            <begin position="609"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="534"/>
            <end position="561"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00073589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAG04842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="696" mass="77312" checksum="AACCA27169D17EF7" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CE40</accession>
    <name>A0A177CE40_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1218456</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG05069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035434.1">
        <property type="nucleotide sequence ID" value="XM_018183000.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CE40"/>
    <dbReference type="GeneID" id="28766486"/>
    <dbReference type="InParanoid" id="A0A177CE40"/>
    <dbReference type="OrthoDB" id="62952at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038883">
        <property type="entry name" value="AN11006-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085:SF2">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG05069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="240" mass="26838" checksum="FAFEFF4216D48186" modified="2016-09-07" version="1">MPAELRVMVYEALVVGSEPITVLREEQTNETHQLDLSLLRVNRQIHDEAAAVFYCKNTFCIRPGKGKDVCGGVPAPRYLHLVRHLKVEGFLHPDTPGKAWAKKQGGLGQDGDGNQENERYISILTTLLPQLRNLHTIHLTITPPDRLSSKSVLAALLPLKHALPSILASLSPLVPILLSFEFDDCYCRLRVSPEFLRKDCLVLLPLTRATTRLFFNDSEIPHFTTQPSQDFVQISHMGSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CEH9</accession>
    <name>A0A177CEH9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HET-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1074850</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG06035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036400.1">
        <property type="nucleotide sequence ID" value="XM_018173702.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CEH9"/>
    <dbReference type="STRING" id="1460663.A0A177CEH9"/>
    <dbReference type="GeneID" id="28757188"/>
    <dbReference type="InParanoid" id="A0A177CEH9"/>
    <dbReference type="OrthoDB" id="674604at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058525">
        <property type="entry name" value="DUF8212"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF10">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26640">
        <property type="entry name" value="DUF8212"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="23"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="DUF8212" evidence="2">
        <location>
            <begin position="243"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG06035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="266" mass="31058" checksum="B3C9F683AF36F1A8" modified="2016-09-07" version="1" fragment="single">MRLLSTKSLQLEQFNDEERLPPYAILSHTWGEEEVTLDDLLREHVQTMIGYRKIEQTCRIAAQDGFGYVWIDTCCIDKSSSAELSEAINSMFRWYALSQKCYAYLEDLVWHEGQSSGVGSHQYGNAHSLQRSRWFTRGWTLQELIAPSEVYFYDKYWTLTGTRTALADILAKITSVDLEVLVNLDLYISRTQHLKVFLRERSVAQRMSWASKRKTTRPEDLAYCLLGIFDIHMPLLYGEGIEKAFRRLQMEILRYSTDQSILAWKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CEM2</accession>
    <name>A0A177CEM2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">TauD-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_1165541</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TfdA dioxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG05228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035593.1">
        <property type="nucleotide sequence ID" value="XM_018178741.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CEM2"/>
    <dbReference type="FunCoup" id="A0A177CEM2">
        <property type="interactions" value="3"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CEM2"/>
    <dbReference type="GeneID" id="28762227"/>
    <dbReference type="InParanoid" id="A0A177CEM2"/>
    <dbReference type="OrthoDB" id="10257314at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016706">
        <property type="term" value="F:2-oxoglutarate-dependent dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.130.10:FF:000003">
        <property type="entry name" value="Alpha-ketoglutarate-dependent taurine dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051323">
        <property type="entry name" value="AtsK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT SULFONATE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468:SF1">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT SULFONATE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="7">
        <location>
            <begin position="93"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAG05228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="376" mass="41867" checksum="7E567EFB32FE3AAD" modified="2016-09-07" version="1">MAPALVEVPLPEATNYAKSGTGAYKDAFAAGPKHFKADAELKGTEKHPPAKYPNYLPTWTDKKYPPLEPFEHYEHGKDADSSFSNLLKDATKVDDLTANIGAEVHGVQLSKLTDAGKDELALFVAQKKVVAFRDQDFADLPISDALKIGGYFGRHHIHPTSGGPEGHPEVHLVHRSADDTTSRDFFEERTNSVTWHSDVTYEKQPPGTTFLYLLDGPAAGGDTLFANQALAYRRLSPEFQKRLHGLKVVHSAVEQADNSRNRGGIVRREPVTSIHPLVRTHPTTGEKALFINPQFSRRIVGYKKEESDYLLNFLYDHLAKGQDFQARVKWAPGTVVVWDNRVTAHSALLDWEDGARRHLARITPQAEAPYETPFEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CF51</accession>
    <name>A0A177CF51_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CRIB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_721398</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG05387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035752.1">
        <property type="nucleotide sequence ID" value="XM_018187162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CF51"/>
    <dbReference type="STRING" id="1460663.A0A177CF51"/>
    <dbReference type="GeneID" id="28770648"/>
    <dbReference type="InParanoid" id="A0A177CF51"/>
    <dbReference type="OrthoDB" id="24581at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000095">
        <property type="entry name" value="CRIB_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50108">
        <property type="entry name" value="CRIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRIB" evidence="2">
        <location>
            <begin position="153"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="244"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="344"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="435"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="491"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="553"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="619"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="705"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="753"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="16"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="244"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="302"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="395"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="450"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="504"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="557"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="642"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="756"/>
            <end position="765"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG05387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="812" mass="88273" checksum="B7488A401338C4C5" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CFI4</accession>
    <name>A0A177CFI4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_1217600</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG06373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036738.1">
        <property type="nucleotide sequence ID" value="XM_018182912.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CFI4"/>
    <dbReference type="GeneID" id="28766398"/>
    <dbReference type="InParanoid" id="A0A177CFI4"/>
    <dbReference type="OrthoDB" id="3648173at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF156">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="67"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="102"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="147"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="199"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="229"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="64"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAG06373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="367" mass="40298" checksum="0A729EE6245380DF" modified="2016-09-07" version="1">MAAGPYFPSIDQFPPGYAEENNSRPLLETCIAFLVLDTTFMILLYTSRFLCNDKKHSSEQRANWSMISLMTGTYIVCISKITLGFLAIHVGGAGRHTATLDYATITTALQINTALQLICPLTTSLSKMSILCLLHTIFGRTSERTRLVIRITFVLCLITLLVQVIIPFANCRPFSASWTLGQQSQCAISGLALWKYLSIPNVIGTLVVVAIPLPALYKLRVSAATKLGLAVVLSVCVCGVVAAIMRFVSFVRVMSFDDFSYEQIDPLRWTIAESGIYMVAGVLPTLRPLMKKLFGNTTFERILTGRFRSSGSGKSGVSDVSWGHKRGSVMGRGDVDEVALVKKEKKLSALSTEETVVGFEDEEKIKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CFX7</accession>
    <name>A0A177CFX7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Mitochondrial import inner membrane translocase subunit TIM14</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Mitochondrial import inner membrane translocase subunit tim14</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11 13">Presequence translocated-associated motor subunit PAM18</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CC84DRAFT_1164538</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the TIM14 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG06226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036591.1">
        <property type="nucleotide sequence ID" value="XM_018178506.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CFX7"/>
    <dbReference type="FunCoup" id="A0A177CFX7">
        <property type="interactions" value="26"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CFX7"/>
    <dbReference type="GeneID" id="28761992"/>
    <dbReference type="InParanoid" id="A0A177CFX7"/>
    <dbReference type="OrthoDB" id="240298at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001405">
        <property type="term" value="C:PAM complex, Tim23 associated import motor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001671">
        <property type="term" value="F:ATPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000001">
        <property type="entry name" value="Import inner membrane translocase subunit tim14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12763">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12763:SF28">
        <property type="entry name" value="GEO10507P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0143">Chaperone</keyword>
    <keyword evidence="7 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0811">Translocation</keyword>
    <keyword evidence="2 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="15">
        <location>
            <begin position="50"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00040828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00041716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00067223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00075483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OAG06226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="105" mass="11525" checksum="6E0FFEDAAC20746C" modified="2016-09-07" version="1">MSLWVWGIGLGAAAFFGRAGLVALRRSGGGAGALGRGFYKGGFEPKMTRKEAALILEMPERGVTKELLRKKHRQLMLLNHPDRGGSPYLATKVNEAKEMLEKEIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CG53</accession>
    <name>A0A177CG53_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1162933</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the polyketide transferase af380 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG06564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036929.1">
        <property type="nucleotide sequence ID" value="XM_018178129.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CG53"/>
    <dbReference type="STRING" id="1460663.A0A177CG53"/>
    <dbReference type="ESTHER" id="9pleo-a0a177cg53">
        <property type="family name" value="Thiohydrolase"/>
    </dbReference>
    <dbReference type="GeneID" id="28761615"/>
    <dbReference type="InParanoid" id="A0A177CG53"/>
    <dbReference type="OrthoDB" id="2498029at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051411">
        <property type="entry name" value="Polyketide_trans_af380"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47751:SF2">
        <property type="entry name" value="DLTD N-TERMINAL DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_8G00380)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47751">
        <property type="entry name" value="SUPERFAMILY HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G16580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="33"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00029464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG06564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="302" mass="33178" checksum="1627498CABFEFD90" modified="2016-09-07" version="1">MGLSEQDVEFKTLDGTVLRGTLYPTSNRGPAIVMSPGFNCVKEMLGLPDAAARFQSAGYTVLLYDPRTTGLSGGEPRNDIDPIAQVGDYSDAISYISTLSSVNPSEVFIWGMSFSAAVGLCVAALDPRAKGIIAVCPLTDFTYTEEKLPMVLKKCAQDRASQVAGNDPFYLPMLDAQGRNPAGFGVGVDSEQYSKIVEAGKEIAPRHVNRTTVQTYYRMVLWQPFGLWRMIKNLPVLFVVPELDRLSPAERQLGHWDSLVCPKRKVLVPGVGHMEIMEGDHVDEIMTDMEKFLRDVLEGSVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CGH2</accession>
    <name>A0A177CGH2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HET-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1163008</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG06674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037039.1">
        <property type="nucleotide sequence ID" value="XM_018178151.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CGH2"/>
    <dbReference type="STRING" id="1460663.A0A177CGH2"/>
    <dbReference type="GeneID" id="28761637"/>
    <dbReference type="InParanoid" id="A0A177CGH2"/>
    <dbReference type="OrthoDB" id="20872at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058525">
        <property type="entry name" value="DUF8212"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF12">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26640">
        <property type="entry name" value="DUF8212"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="25"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="DUF8212" evidence="2">
        <location>
            <begin position="223"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG06674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="550" mass="62889" checksum="9EAC6E680DAEB250" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CGZ8</accession>
    <name>A0A177CGZ8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1162975</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG06616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036981.1">
        <property type="nucleotide sequence ID" value="XM_018178142.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CGZ8"/>
    <dbReference type="GeneID" id="28761628"/>
    <dbReference type="InParanoid" id="A0A177CGZ8"/>
    <dbReference type="OrthoDB" id="2121326at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG06616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="105" mass="10905" checksum="5DA573789222AFA8" modified="2016-09-07" version="1">MSESKSSASPMATLTTFLALYLTTLFSLDTWTAARNSPYRAPSATSFYRPAGAQSEYQAGMHGQGRRGPAGRGSGGGRQGRLPATLDTRAPLRAGSTAQCGACAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2023-06-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CHC1</accession>
    <name>A0A177CHC1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_619848</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG06726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037091.1">
        <property type="nucleotide sequence ID" value="XM_018186901.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CHC1"/>
    <dbReference type="GeneID" id="28770387"/>
    <dbReference type="InParanoid" id="A0A177CHC1"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG06726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="164" mass="17933" checksum="D910087AC1B1DE76" modified="2016-09-07" version="1">MKSPCNTVSYRYSALCPHRSTGLPQARSDVLHGCRPRQTHGRDSVHHLPVEAESYQRLSPTCMVSASTSAGAGLACHTQYQFRTGTAASHKLRPDLEQRCLVATASMERVIAMRSCTRASDQIITLLWYNRAAIRRANGAGARHRVLGGPAVREGAGHRIARQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CHT3</accession>
    <name>A0A177CHT3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sfi1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_763873</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG06419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036784.1">
        <property type="nucleotide sequence ID" value="XM_018187353.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CHT3"/>
    <dbReference type="STRING" id="1460663.A0A177CHT3"/>
    <dbReference type="GeneID" id="28770839"/>
    <dbReference type="InParanoid" id="A0A177CHT3"/>
    <dbReference type="OrthoDB" id="5215300at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013665">
        <property type="entry name" value="Sfi1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08457">
        <property type="entry name" value="Sfi1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sfi1 spindle body" evidence="2">
        <location>
            <begin position="358"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1047"/>
            <end position="1117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1138"/>
            <end position="1160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG06419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="1160" mass="134354" checksum="D2D987ED876FC6AA" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CIB0</accession>
    <name>A0A177CIB0_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">GPI-anchored cell wall organization protein Ecm33</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_1117426</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Cell wall</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG07245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037610.1">
        <property type="nucleotide sequence ID" value="XM_018175494.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CIB0"/>
    <dbReference type="FunCoup" id="A0A177CIB0">
        <property type="interactions" value="101"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CIB0"/>
    <dbReference type="GeneID" id="28758980"/>
    <dbReference type="InParanoid" id="A0A177CIB0"/>
    <dbReference type="OrthoDB" id="536881at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.20.20">
        <property type="entry name" value="Receptor L-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051648">
        <property type="entry name" value="CWI-Assembly_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036941">
        <property type="entry name" value="Rcpt_L-dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31018:SF3">
        <property type="entry name" value="RECEPTOR PROTEIN-TYROSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31018">
        <property type="entry name" value="SPORULATION-SPECIFIC PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12454">
        <property type="entry name" value="Ecm33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0134">Cell wall</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 7" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008058221" description="GPI-anchored cell wall organization protein Ecm33" evidence="7">
        <location>
            <begin position="20"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="375"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAG07245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="397" mass="41179" checksum="D075FDF710AFA7CA" modified="2016-09-07" version="1">MSLFRVALPALAVVGSAYAASCSNSATSTIQNGGDATAIASCTTYSGSIAVATGLADDIALDGNLKKIDGDLVLESNSDIKRFGSSSLQSISGKLTLNDVSQLAALSFPALTEVDELTLKGLPNLRALEFNLTKADKLDIENTKLQNLDGIDLDEVSSIFIANNDDIASIEMQVTNITEFITLSFNNAMVNVSFPKLESANNISFRAIGSLNIPVLSKINSGSFGVFESDNLESVSAPNLTKIDGALVIDNNKGLKNISFASLTDVGANLQIANNTNLHQIDGLPKLKNVQAALDMSGNFSKVETPSLDYVKGVFNLQSTGDIGTVCDDFYNPLKAKGKLQKGKYVCQGKLEEANTAGSSPKSGSGSGSGGDKGAAVGLAVPSISLGLVGLAAVLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CIP4</accession>
    <name>A0A177CIP4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">D-lactate dehydratase</fullName>
            <ecNumber evidence="1">4.2.1.130</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_1090094</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>methylglyoxal + H2O = (R)-lactate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27754"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16004"/>
            <dbReference type="ChEBI" id="CHEBI:17158"/>
            <dbReference type="EC" id="4.2.1.130"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="4.2.1.130" evidence="1"/>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG07131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037496.1">
        <property type="nucleotide sequence ID" value="XM_018174339.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CIP4"/>
    <dbReference type="STRING" id="1460663.A0A177CIP4"/>
    <dbReference type="GeneID" id="28757825"/>
    <dbReference type="InParanoid" id="A0A177CIP4"/>
    <dbReference type="OrthoDB" id="543156at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019172">
        <property type="term" value="F:glyoxalase III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903189">
        <property type="term" value="P:glyoxal metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03135">
        <property type="entry name" value="GATase1_DJ-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006287">
        <property type="entry name" value="DJ-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050325">
        <property type="entry name" value="Prot/Nucl_acid_deglycase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01383">
        <property type="entry name" value="not_thiJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48094:SF12">
        <property type="entry name" value="PARKINSON DISEASE PROTEIN 7 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48094">
        <property type="entry name" value="PROTEIN/NUCLEIC ACID DEGLYCASE DJ-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DJ-1/PfpI" evidence="3">
        <location>
            <begin position="3"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00048082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAG07131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="197" mass="21147" checksum="8F69263E997299A0" modified="2016-09-07" version="1">MPKVLILVADGSEEIEFVTPYDVFTRAGFEVVSAGVELKENYAHMTRNIRIIPDFPSLLSLGQQALHEQHDILVLPGGGPGAKTFATSAPVLDLINAFRDAGKYVAAICAGTTALVAAQKKHGGEKGRVTSHPSVRAEVETKGGWEYSEERVVIDRNLITSRGPGTALLFALTIVEALAGREKRDKVALPMIVAETL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CJB5</accession>
    <name>A0A177CJB5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Clavaminate synthase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_1143017</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TfdA dioxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG06877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037242.1">
        <property type="nucleotide sequence ID" value="XM_018176389.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CJB5"/>
    <dbReference type="STRING" id="1460663.A0A177CJB5"/>
    <dbReference type="GeneID" id="28759875"/>
    <dbReference type="InParanoid" id="A0A177CJB5"/>
    <dbReference type="OrthoDB" id="93019at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051178">
        <property type="entry name" value="TfdA_dioxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43779:SF2">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT XANTHINE DIOXYGENASE XAN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43779">
        <property type="entry name" value="DIOXYGENASE RV0097-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="7">
        <location>
            <begin position="17"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAG06877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="377" mass="42253" checksum="06630F7727E61499" modified="2016-09-07" version="1">MPHATASDIIVRPLPSRPGSKYTIGAELLNANLESLTPHDEATIKHALYTHQVILFKNQSALTPSAQYAVTRLFDPAATSYGHGKTLDAKRSVLHPDLKTIPHQPQVQVIGNGFVEEFEGLKDINLKHPHHRTFHRDVLSDELDRDNTRFYRWHIDAALYDLEPPMATSLLAVEVPKTECQTLRYDDGTGDEMRVPRGSTVFVSGETMYDVLSEEDKKFARETKVQYAPHPYIWMSGARSRSTGLGMVCEGLELDAAQLPPVEEDKIKILPMCWKNPVTGKLALQIHPSAVQKLVLKDGTVVDDLEEVRKIVYRLQRPGIAPELVFPIDWDEGDFAIFNNRGVLHSVTGSFLPEEVRIFRQCNMAASQPVEGPEECA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CJP0</accession>
    <name>A0A177CJP0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1089430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG07192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037557.1">
        <property type="nucleotide sequence ID" value="XM_018174306.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CJP0"/>
    <dbReference type="STRING" id="1460663.A0A177CJP0"/>
    <dbReference type="GeneID" id="28757792"/>
    <dbReference type="InParanoid" id="A0A177CJP0"/>
    <dbReference type="OrthoDB" id="5339776at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025040">
        <property type="entry name" value="DUF3984"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13136">
        <property type="entry name" value="DUF3984"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="223"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="328"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="379"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="11"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="65"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="328"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="344"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG07192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="423" mass="46763" checksum="B75312CAB9FA17AD" modified="2016-09-07" version="1">MDPPRSRSTRRSYPNLNLNNLSLAPLSKQYPLDASAPPSPDEDRIYTPRTSYIAQKSAPTTPGILSLSQSRSNSRNGRRKTKAYAYDGYFMNPDVPVRDAGDVPKAKSTTALLPGVSFVDQPKGRHHARKGTAPLPLRPPHVRHHTSESANEWFHRAGMVIAGETRDSKGQGWLVRRESSTSLVHQSDDYEEHPSHDGRHMALLSGEHLADFEYSTFTPRYSRAGSRAQSRVVSRVPSARTSRRGSRVGSRADLVMTASGMRTPGGRRSLELDDDSMFEESPIEADFVEADEENEGDEEEIARLARERGFGLGTWVDRLMGWTLFSVDEDGEESSSDDEDEDETPRPENMTKEELKLRREVDAKRRKLEREAIIAAAAVQAPNSKNNAGEETDAAGDKLPPGEEGGGWADAAWLVSVAAKVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CJU2</accession>
    <name>A0A177CJU2_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Hypervirulence associated protein TUDOR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1204700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG07109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037474.1">
        <property type="nucleotide sequence ID" value="XM_018181922.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CJU2"/>
    <dbReference type="STRING" id="1460663.A0A177CJU2"/>
    <dbReference type="GeneID" id="28765408"/>
    <dbReference type="InParanoid" id="A0A177CJU2"/>
    <dbReference type="OrthoDB" id="3360421at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG07109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="197" mass="21612" checksum="90FF967C7A4A68C7" modified="2016-09-07" version="1">MPSSKGKPTDPKLREKVKEEVKNETNKDGGGKGQWSAWKASKLSKEYEKRGGDYENEAGSKNEPKKGAPQPKSGGKKQKEENKAQGDDAASLDDEEQVEEDAEEDAKEDVQEDAEEDEGAKHKANTAKKAKPAKPAAAKKTGSRPKKEGAEKKENANSKMKEEKKPAEGTRKSERNAGKRKDYGEEGGEKEKKKAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CJZ7</accession>
    <name>A0A177CJZ7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CC84DRAFT_1175025</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG07169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037534.1">
        <property type="nucleotide sequence ID" value="XM_018180126.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CJZ7"/>
    <dbReference type="FunCoup" id="A0A177CJZ7">
        <property type="interactions" value="1367"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CJZ7"/>
    <dbReference type="GeneID" id="28763612"/>
    <dbReference type="InParanoid" id="A0A177CJZ7"/>
    <dbReference type="OrthoDB" id="2241241at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17356">
        <property type="entry name" value="MFS_HXT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000044">
        <property type="entry name" value="Hexose transporter Hxt3p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF39">
        <property type="entry name" value="MONOSACCHARIDE TRANSPORTER, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="40"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="121"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="145"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="180"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="214"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="303"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="337"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="370"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="401"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="439"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="469"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="43"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="511"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="10"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OAG07169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="569" mass="63505" checksum="1C343DD612857801" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CK51</accession>
    <name>A0A177CK51_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1063600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG07904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038269.1">
        <property type="nucleotide sequence ID" value="XM_018173612.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CK51"/>
    <dbReference type="GeneID" id="28757098"/>
    <dbReference type="InParanoid" id="A0A177CK51"/>
    <dbReference type="OrthoDB" id="5329403at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="292"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="675"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="301"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="317"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="694"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG07904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="694" mass="75433" checksum="4842AAEAAE212B3E" modified="2016-09-07" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CKL5</accession>
    <name>A0A177CKL5_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cytochrome oxidase c assembly domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CC84DRAFT_1114267</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038430.1">
        <property type="nucleotide sequence ID" value="XM_018175391.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CKL5"/>
    <dbReference type="STRING" id="1460663.A0A177CKL5"/>
    <dbReference type="GeneID" id="28758877"/>
    <dbReference type="InParanoid" id="A0A177CKL5"/>
    <dbReference type="OrthoDB" id="4205486at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029208">
        <property type="entry name" value="COX14"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14880">
        <property type="entry name" value="COX14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAG08065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="262" mass="28900" checksum="3F0073A6AE0DF71C" modified="2016-09-07" version="1">MSKSPKESTRFTATGVWAHTRPGGKATTLQFADPAPKNETPQQKVKRLREAANRAKLAQVTRWDYAYMYGRMAADAVHRFTVYGIIFATGCIGVLAVFSIGDMVVYNRRKRAIFFEDQEREQAKILSIARTAVAEGRATPAQAALVEGIAEEERLMDLKKAERKAPSKILWWLHGEWNEDKALKEQRRLAVEDFQKKEMQAAGQGSVTQAVQAAQQARSDNAQPAVGGPLDQQAAKATAFAENTVKGASSGWFGWLGGSKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CL52</accession>
    <name>A0A177CL52_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="16">p-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CC84DRAFT_1163687</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AAA ATPase family. BCS1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG07559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037924.1">
        <property type="nucleotide sequence ID" value="XM_018178317.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CL52"/>
    <dbReference type="STRING" id="1460663.A0A177CL52"/>
    <dbReference type="GeneID" id="28761803"/>
    <dbReference type="InParanoid" id="A0A177CL52"/>
    <dbReference type="OrthoDB" id="10251412at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057495">
        <property type="entry name" value="AAA_lid_BCS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014851">
        <property type="entry name" value="BCS1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050747">
        <property type="entry name" value="Mitochondrial_chaperone_BCS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23070">
        <property type="entry name" value="BCS1 AAA-TYPE ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25426">
        <property type="entry name" value="AAA_lid_BCS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08740">
        <property type="entry name" value="BCS1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01024">
        <property type="entry name" value="BCS1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="4 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="BCS1 N-terminal" evidence="15">
        <location>
            <begin position="71"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="14">
        <location>
            <begin position="294"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="363"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="530"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="367"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OAG07559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="562" mass="61792" checksum="9247AFA2CED832FB" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CL76</accession>
    <name>A0A177CL76_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HET-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1185188</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038650.1">
        <property type="nucleotide sequence ID" value="XM_018180792.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CL76"/>
    <dbReference type="STRING" id="1460663.A0A177CL76"/>
    <dbReference type="GeneID" id="28764278"/>
    <dbReference type="InParanoid" id="A0A177CL76"/>
    <dbReference type="OrthoDB" id="4161196at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF10">
        <property type="entry name" value="TOL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="139"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG08285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="551" mass="63287" checksum="E2336B7FF494D0DA" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CL77</accession>
    <name>A0A177CL77_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">UPF0016-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CC84DRAFT_1114610</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GDT1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038628.1">
        <property type="nucleotide sequence ID" value="XM_018175400.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CL77"/>
    <dbReference type="FunCoup" id="A0A177CL77">
        <property type="interactions" value="676"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CL77"/>
    <dbReference type="GeneID" id="28758886"/>
    <dbReference type="InParanoid" id="A0A177CL77"/>
    <dbReference type="OrthoDB" id="442680at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015085">
        <property type="term" value="F:calcium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005384">
        <property type="term" value="F:manganese ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032468">
        <property type="term" value="P:Golgi calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032472">
        <property type="term" value="P:Golgi calcium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001727">
        <property type="entry name" value="GDT1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049555">
        <property type="entry name" value="GDT1-like_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12608:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 165"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12608">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN HTP-1 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01169">
        <property type="entry name" value="GDT1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01214">
        <property type="entry name" value="UPF0016"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008058353" evidence="8">
        <location>
            <begin position="24"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="293"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="325"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="435"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="473"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="506"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="58"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="350"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="62"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="144"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="211"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="230"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="400"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAG08263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="530" mass="55970" checksum="EE407DC7105B95AB" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CMA0</accession>
    <name>A0A177CMA0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_1203804</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038791.1">
        <property type="nucleotide sequence ID" value="XM_018181853.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CMA0"/>
    <dbReference type="STRING" id="1460663.A0A177CMA0"/>
    <dbReference type="GeneID" id="28765339"/>
    <dbReference type="InParanoid" id="A0A177CMA0"/>
    <dbReference type="OrthoDB" id="1658288at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056681">
        <property type="entry name" value="DUF7779"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053137">
        <property type="entry name" value="NLR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031352">
        <property type="entry name" value="SesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082:SF6">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082">
        <property type="entry name" value="ATP/GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25000">
        <property type="entry name" value="DUF7779"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17107">
        <property type="entry name" value="SesA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13374">
        <property type="entry name" value="TPR_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="NACHT-NTPase and P-loop NTPases N-terminal" evidence="2">
        <location>
            <begin position="248"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7779" evidence="3">
        <location>
            <begin position="735"/>
            <end position="810"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAG08426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="985" mass="108659" checksum="1385C8771E78A6EF" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CMK8</accession>
    <name>A0A177CMK8_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">F-actin-capping protein subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CC84DRAFT_1141750</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 10">F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the F-actin capping complex, composed of a heterodimer of an alpha and a beta subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Heterodimer of an alpha and a beta subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Actin patch</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the F-actin-capping protein beta subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039149.1">
        <property type="nucleotide sequence ID" value="XM_018176339.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CMK8"/>
    <dbReference type="FunCoup" id="A0A177CMK8">
        <property type="interactions" value="865"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CMK8"/>
    <dbReference type="GeneID" id="28759825"/>
    <dbReference type="InParanoid" id="A0A177CMK8"/>
    <dbReference type="OrthoDB" id="9979678at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099079">
        <property type="term" value="C:actin body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000142">
        <property type="term" value="C:cellular bud neck contractile ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005934">
        <property type="term" value="C:cellular bud tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008290">
        <property type="term" value="C:F-actin capping protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000131">
        <property type="term" value="C:incipient cellular bud site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031097">
        <property type="term" value="C:medial cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044396">
        <property type="term" value="P:actin cortical patch organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051016">
        <property type="term" value="P:barbed-end actin filament capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030447">
        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904600">
        <property type="term" value="P:mating projection actin fusion focus assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903475">
        <property type="term" value="P:mitotic actomyosin contractile ring assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902404">
        <property type="term" value="P:mitotic actomyosin contractile ring contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.570:FF:000001">
        <property type="entry name" value="F-actin-capping protein subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.210:FF:000005">
        <property type="entry name" value="F-actin-capping protein subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.210">
        <property type="entry name" value="F-actin capping protein, beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037282">
        <property type="entry name" value="CapZ_alpha/beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042276">
        <property type="entry name" value="CapZ_alpha/beta_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001698">
        <property type="entry name" value="CAPZB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043175">
        <property type="entry name" value="CAPZB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019771">
        <property type="entry name" value="F-actin_capping_bsu_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10619">
        <property type="entry name" value="F-ACTIN-CAPPING PROTEIN SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10619:SF0">
        <property type="entry name" value="F-ACTIN-CAPPING PROTEIN SUBUNIT BETA ISOFORMS 1 AND 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01115">
        <property type="entry name" value="F_actin_cap_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00192">
        <property type="entry name" value="FACTINCAPB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90096">
        <property type="entry name" value="Subunits of heterodimeric actin filament capping protein Capz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00231">
        <property type="entry name" value="F_ACTIN_CAPPING_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0117">Actin capping</keyword>
    <keyword evidence="6 10" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="5 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OAG08784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="260" mass="29388" checksum="28A232F11B2C390F" modified="2016-09-07" version="1">MAEPIDSALDLLRRLNPKDVKQNVDNIIELNPSLEEELLESVDIPLSVKRCSSTKRDFLCCDYNRDGDSWRSPWSNNFEPPIDEGITPSERIRKMEIKANEAFDVYRELYFEGGISSVYLWDMDDGFAGCVLLKKSVKGGSWDSIHVFDAQDRARTAHYKLTSTVILSLGTESEALGGLDLSGNMVRQVEQDMAVEDDGSHVANIGKMVEDMELKMRNLLQEVYFGKAKDVVGDLRSIPPLSVTNRDRQTQREMISSMSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CMX9</accession>
    <name>A0A177CMX9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Antiviral helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CC84DRAFT_1140621</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the helicase family. SKI2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038514.1">
        <property type="nucleotide sequence ID" value="XM_018176291.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A177CMX9">
        <property type="interactions" value="936"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CMX9"/>
    <dbReference type="GeneID" id="28759777"/>
    <dbReference type="InParanoid" id="A0A177CMX9"/>
    <dbReference type="OrthoDB" id="64767at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055087">
        <property type="term" value="C:Ski complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070478">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18795">
        <property type="entry name" value="SF2_C_Ski2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000354">
        <property type="entry name" value="ATP-dependent RNA helicase SKI2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000987">
        <property type="entry name" value="DEAD/DEAH box RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3380.30:FF:000001">
        <property type="entry name" value="Ski2 ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3380.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1500.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025696">
        <property type="entry name" value="Beta-barrel_MTR4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048392">
        <property type="entry name" value="MTR4-like_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050699">
        <property type="entry name" value="RNA-DNA_Helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016438">
        <property type="entry name" value="SKI2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012961">
        <property type="entry name" value="Ski2/MTR4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040801">
        <property type="entry name" value="Ski2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131">
        <property type="entry name" value="ATP-DEPENDENT RNA AND DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131:SF1">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE SUPV3L1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08148">
        <property type="entry name" value="DSHCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21408">
        <property type="entry name" value="MTR4-like_stalk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13234">
        <property type="entry name" value="MTR4_beta-barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17911">
        <property type="entry name" value="Ski2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005198">
        <property type="entry name" value="Antiviral_helicase_SKI2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01142">
        <property type="entry name" value="DSHCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 12" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="327"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="605"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="194"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="527"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="201"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="558"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="569"/>
            <end position="578"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OAG08149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="1285" mass="144038" checksum="606F6A9CEB438A35" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CN68</accession>
    <name>A0A177CN68_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Heavy metal tolerance protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CC84DRAFT_1173906</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the ABC transporter superfamily. ABCB family. Heavy Metal importer (TC 3.A.1.210) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038787.1">
        <property type="nucleotide sequence ID" value="XM_018180065.1"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CN68"/>
    <dbReference type="GeneID" id="28763551"/>
    <dbReference type="InParanoid" id="A0A177CN68"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000287">
        <property type="entry name" value="Multidrug ABC transporter ATP-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221:SF503">
        <property type="entry name" value="MITOCHONDRIAL POTASSIUM CHANNEL ATP-BINDING SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="212"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="287"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="316"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="344"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="449"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="488"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="518"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="578"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="706"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="452"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="770"/>
            <end position="1005"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="118"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="385"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1014"/>
            <end position="1161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1176"/>
            <end position="1252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="126"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="385"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1014"/>
            <end position="1030"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="1037"/>
            <end position="1047"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="1070"/>
            <end position="1081"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1082"/>
            <end position="1091"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="1092"/>
            <end position="1102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1122"/>
            <end position="1131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1139"/>
            <end position="1154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1202"/>
            <end position="1231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OAG08422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1318" mass="147395" checksum="43012818B75A3A6A" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CNE5</accession>
    <name>A0A177CNE5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_576746</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038785.1">
        <property type="nucleotide sequence ID" value="XM_018186735.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CNE5"/>
    <dbReference type="GeneID" id="28770221"/>
    <dbReference type="InParanoid" id="A0A177CNE5"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG08420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="139" mass="15844" checksum="FD9EC91C174E3A32" modified="2016-09-07" version="1">MSHFLVLSMFARSSGFSPPRCLRTLCHSCCVPMLAQHHVPKPSRSRSLFRSPFPERRQRTRDHVFRTRQCPFSNNHLPHHQMALAKKRPQQIMSMSVAVDLRSTVAPTEPHSLAPPRRTTQTLNITAAARPRLTSSLLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CP11</accession>
    <name>A0A177CP11_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">N-acetylglucosamine-6-phosphate deacetylase</fullName>
            <ecNumber evidence="2">3.5.1.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CC84DRAFT_1203859</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>N-acetyl-D-glucosamine 6-phosphate + H2O = D-glucosamine 6-phosphate + acetate</text>
            <dbReference type="Rhea" id="RHEA:22936"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:57513"/>
            <dbReference type="ChEBI" id="CHEBI:58725"/>
            <dbReference type="EC" id="3.5.1.25"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="10">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-dependent hydrolases superfamily. NagA family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.25" evidence="2"/>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038872.1">
        <property type="nucleotide sequence ID" value="XM_018181859.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CP11"/>
    <dbReference type="STRING" id="1460663.A0A177CP11"/>
    <dbReference type="GeneID" id="28765345"/>
    <dbReference type="InParanoid" id="A0A177CP11"/>
    <dbReference type="OrthoDB" id="10264777at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008448">
        <property type="term" value="F:N-acetylglucosamine-6-phosphate deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006046">
        <property type="term" value="P:N-acetylglucosamine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00854">
        <property type="entry name" value="NagA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000065">
        <property type="entry name" value="N-acetylglucosamine-6-phosphate deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003764">
        <property type="entry name" value="GlcNAc_6-P_deAcase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00221">
        <property type="entry name" value="nagA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11113">
        <property type="entry name" value="N-ACETYLGLUCOSAMINE-6-PHOSPHATE DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11113:SF14">
        <property type="entry name" value="N-ACETYLGLUCOSAMINE-6-PHOSPHATE DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038994">
        <property type="entry name" value="NagA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="11">
        <location>
            <begin position="71"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="8">
        <location>
            <position position="313"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="252"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="255"/>
            <end position="256"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="263"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="291"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="348"/>
            <end position="350"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR038994-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR038994-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR038994-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OAG08507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="440" mass="46305" checksum="060C07F61326D16C" modified="2016-09-07" version="1">MPSVVRPVGTAAVTRRSGVVKFTNCRLVKGTDLVHEDLWVSSVTGKILNGQELLYGHRTAPDDIIDLGGRILSPGLIDVQLNGAYGFDFSVIPEDGSIAYGKGVQQVNRNLVKGGVTSYLPTLTSQRPEVYHKALPYLGPSGSTRDPALGSESLGAHCEGPFMSPTKNGIHNVSVLQVPRDGIASVAGCYGPSNLTQPSPIKLVTLAPELPGALSAIQSLASLGIIASIGHSEATYEEAKLGIKAGASSITHLFNAMKPLHHRNPGIFGLLGTASSSISKPYFGIIADGIHIHPTSIKIAYNAHPEGLILVTDAMRLSGMPDGVYDWTNGSRIVKQGALLTLEENGKIAGSSIELIDCVTNFMNWTGASVPEAIKAVTETPASMLGLAGVKGSLQEGADADLVVLDVQEGAVGEDKRVVVDQVWKFGVKVHEREDGQLKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CPE3</accession>
    <name>A0A177CPE3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glutaredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1257544</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039115.1">
        <property type="nucleotide sequence ID" value="XM_018184742.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CPE3"/>
    <dbReference type="STRING" id="1460663.A0A177CPE3"/>
    <dbReference type="GeneID" id="28768228"/>
    <dbReference type="InParanoid" id="A0A177CPE3"/>
    <dbReference type="OrthoDB" id="9932926at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00570">
        <property type="entry name" value="GST_N_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="178"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="238"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="254"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="306"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG08750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="340" mass="35649" checksum="B9820157B6DE47BC" modified="2016-09-07" version="1">MAELAVYDNDPTLYLFTSLTAGSSHIITATSRIETILKANKIPFKGVDTATDELAKKLFQRRARGKKLPLLVKEGFVIADLDQVEEWNEYDELKEALGAPAVPAPAVAVPLAASKTPSAPAASAAVGSAPGKENTPKQTPEQNLAIRQLGAEAASIAAAKKHVPAKISTTNPLLTAKASASSTPTSATTPSKPAVASPSAILSPRSIPLPSTPANVGKAQGEVVSEFHGRRVQSPGAEEIKMVEEQTAIKEVSSSEEEDSEEEDEEDSEEDSEEEEEEDDDEEEEEEETAQPAKIPAKADAKDAANEAPKPDAAAGVKKEAPTQAQPAKAADKAGVSVED</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CPW5</accession>
    <name>A0A177CPW5_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SGF29 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1160704</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG09575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039940.1">
        <property type="nucleotide sequence ID" value="XM_018177560.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CPW5"/>
    <dbReference type="STRING" id="1460663.A0A177CPW5"/>
    <dbReference type="GeneID" id="28761046"/>
    <dbReference type="InParanoid" id="A0A177CPW5"/>
    <dbReference type="OrthoDB" id="10265994at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037802">
        <property type="entry name" value="SGF29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010750">
        <property type="entry name" value="SGF29_tudor-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21539">
        <property type="entry name" value="SAGA-ASSOCIATED FACTOR 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21539:SF0">
        <property type="entry name" value="SAGA-ASSOCIATED FACTOR 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07039">
        <property type="entry name" value="SGF29_Tudor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51518">
        <property type="entry name" value="SGF29_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SGF29 C-terminal" evidence="2">
        <location>
            <begin position="199"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="310"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="109"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="319"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG09575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="363" mass="39712" checksum="FF21A600350C33FA" modified="2016-09-07" version="1">MAARSRPRGGQMKDEIDEERHLWNTIRADGRRFDQLMAQSDTLQEKILELAGQQEARKSRGDAPSSRIDNELDAALRENIKLSEEMLTLIKSDQGNDICEQLTVLSALRSADTDSSTSRATNPGKSRDRGQNKRKLTDAADDRDSIAADSPAVPSPKVVLGKDRDRLLPKSGSSRAGSVPAGRESSVKVEDEKDDVKETKQRLTVHTEVLYRAPRSRSGPIQQEGEGTLHRITSVIGEGKQRRYEIIDSDPDPLTPSIPFRASVATIVPIPPAASNLSLPSLEAKKNVLALYPGTTTFYKAEVVDGWKSLPGGNGGGKDGIKKEGGAEEKPGKEAYVTLRFEGEDEVDMVNSVERRYVLPDKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CRP8</accession>
    <name>A0A177CRP8_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ASTRA-associated protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CC84DRAFT_1161190</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Component of the ASTRA complex involved in chromatin remodeling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the ASTRA chromatin remodeling machinery complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the WD repeat ASA1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040570.1">
        <property type="nucleotide sequence ID" value="XM_018177673.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CRP8"/>
    <dbReference type="STRING" id="1460663.A0A177CRP8"/>
    <dbReference type="GeneID" id="28761159"/>
    <dbReference type="InParanoid" id="A0A177CRP8"/>
    <dbReference type="OrthoDB" id="7668193at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19854:SF1">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19854">
        <property type="entry name" value="TRANSDUCIN BETA-LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 7" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="23"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="314"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="387"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00037338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00037931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00040563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAG10205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="525" mass="57142" checksum="CE0F94A384CED2B8" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CRV7</accession>
    <name>A0A177CRV7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glycosyl transferase CAP10 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1161241</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040630.1">
        <property type="nucleotide sequence ID" value="XM_018177684.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CRV7"/>
    <dbReference type="GeneID" id="28761170"/>
    <dbReference type="InParanoid" id="A0A177CRV7"/>
    <dbReference type="OrthoDB" id="202415at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006598">
        <property type="entry name" value="CAP10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051091">
        <property type="entry name" value="O-Glucosyltr/Glycosyltrsf_90"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203:SF107">
        <property type="entry name" value="GLYCOSYL TRANSFERASE CAP10 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203">
        <property type="entry name" value="KDEL LYS-ASP-GLU-LEU CONTAINING - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05686">
        <property type="entry name" value="Glyco_transf_90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00672">
        <property type="entry name" value="CAP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase CAP10" evidence="2">
        <location>
            <begin position="189"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG10265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="471" mass="53765" checksum="96C852DA47269B1E" modified="2016-09-07" version="1">MILRRRCGASDCLAWFFISGIALVFFLICSILYGTRTENPSLPQAVQEVLPAGRCLCQQSTTFNCESCLDCAARPAIVANATHALETWEFDFRRDGSNYGLDEDQCAAAFPGLFEDIERAKNFRKGRGLVTQKNLTDFELTKGMVRAMIHDGQLYILQTCLVDNINRQKAVASLAALHRAISAARDRPAIANIEFVLSVEDLPAQPEKPLWMLARRAQDEDLWLIPDFGWWSWDMPALGAFDEVADEAMQRERLEPWDAKKEKLVWRGKLNFAPKLRRALVEAAKGKSWSDVGQVKWEDTEFKEPGAHFLGPVDQCSYMFIAHAEGRSYSGALKYRQLCRSVIVSHKLQWIQHYHYLLLASGAKQNYVEVERDFSDLSSTMDDLLAHPEKAKRIADNNVKTFRERYLTGAAEACYWRALVQAWKEISFEPSLYETVADGQNKARQQKRGVRYETFILYDYESQVTFPQVAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2023-06-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CRZ9</accession>
    <name>A0A177CRZ9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1236122</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040431.1">
        <property type="nucleotide sequence ID" value="XM_018183874.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CRZ9"/>
    <dbReference type="GeneID" id="28767360"/>
    <dbReference type="InParanoid" id="A0A177CRZ9"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG10066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="187" mass="20879" checksum="E21D1DF9045DA09F" modified="2016-09-07" version="1">MHARLMRDYRSPWGQVQIMYRRMRRRRAQGCEEQWAPDCGSFASHVAPALAWAWPLRRSALLTGTALLRQHVRRARALCGPPALTSVRPCCQVRPFQRASPSPPHQCSAEPVRCVQRQQHRSPAAPVDEGGERVQTGCVLARRCYLLPFRAPAPLVAALAVQGTCCTDKDKEALPPECNPPPTPLRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CS90</accession>
    <name>A0A177CS90_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Methionine permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CC84DRAFT_1235612</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG09750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040115.1">
        <property type="nucleotide sequence ID" value="XM_018183854.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CS90"/>
    <dbReference type="STRING" id="1460663.A0A177CS90"/>
    <dbReference type="GeneID" id="28767340"/>
    <dbReference type="InParanoid" id="A0A177CS90"/>
    <dbReference type="OrthoDB" id="5982228at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000025">
        <property type="entry name" value="High-affinity methionine permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050598">
        <property type="entry name" value="AminoAcid_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785:SF532">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="138"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="181"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="209"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="291"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="343"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="388"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="423"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="453"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="486"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="16"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAG09750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="540" mass="59190" checksum="36087DDEDC4AE276" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CSG0</accession>
    <name>A0A177CSG0_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cation efflux protein transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CC84DRAFT_1184501</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040839.1">
        <property type="nucleotide sequence ID" value="XM_018180751.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CSG0"/>
    <dbReference type="FunCoup" id="A0A177CSG0">
        <property type="interactions" value="91"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CSG0"/>
    <dbReference type="GeneID" id="28764237"/>
    <dbReference type="InParanoid" id="A0A177CSG0"/>
    <dbReference type="OrthoDB" id="435980at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098771">
        <property type="term" value="P:inorganic ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030003">
        <property type="term" value="P:intracellular monoatomic cation homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1510.10:FF:000013">
        <property type="entry name" value="Cation efflux family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1350:FF:000010">
        <property type="entry name" value="Cation efflux family protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1350">
        <property type="entry name" value="Cation efflux protein, cytoplasmic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036837">
        <property type="entry name" value="Cation_efflux_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050291">
        <property type="entry name" value="CDF_Transporter"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43840">
        <property type="entry name" value="MITOCHONDRIAL METAL TRANSPORTER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43840:SF15">
        <property type="entry name" value="MITOCHONDRIAL METAL TRANSPORTER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="9">
        <location>
            <begin position="40"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="362"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="373"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAG10474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="396" mass="42658" checksum="2F9BA92F1EBA8456" modified="2016-09-07" version="1">MSATQTQTRSHGGHSHHHHHDNTYLVSKNKNDAGVRITRIGLYVNLGMAVGKGVGGYVFHSQALVADAIHSLTDLVSDIMTLATVSWSLKPPSERFPSGYGKIESLGSLGVSGILLGGGMMMGWAALVALAQQFFPDAAHFAAEWGLLPHSHGHAHGAGSLGPNINAAWLAGGSILIKEWLYRATLKIANERKSSVLASNAYHHRVDSLTAFVALLMIFGSNMLNNASWLDPVGGLVISFMVIQAGVGNTRDALFELADVGIEKEMSDKVRKAATKALDDINVGSSSDVNVRHVQGVKSGQNYLMDVELGVPGTYSVEQTRGIENLIRERVGAKVRGVKKVRVRFVSNTADQPDFLDEFINLGDGASLSPESESDHEHDHDHDHDHKENGSVKKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CT15</accession>
    <name>A0A177CT15_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Anaphase-promoting complex subunit 5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Cyclosome subunit 5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CC84DRAFT_1193886</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. The APC/C complex catalyzes assembly of branched 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on target proteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the APC5 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040801.1">
        <property type="nucleotide sequence ID" value="XM_018181332.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CT15"/>
    <dbReference type="FunCoup" id="A0A177CT15">
        <property type="interactions" value="125"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CT15"/>
    <dbReference type="GeneID" id="28764818"/>
    <dbReference type="InParanoid" id="A0A177CT15"/>
    <dbReference type="OrthoDB" id="2504561at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045842">
        <property type="term" value="P:positive regulation of mitotic metaphase/anaphase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070979">
        <property type="term" value="P:protein K11-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037679">
        <property type="entry name" value="Apc5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026000">
        <property type="entry name" value="Apc5_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12830">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12830:SF9">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12862">
        <property type="entry name" value="ANAPC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0498">Mitosis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008058642" description="Anaphase-promoting complex subunit 5" evidence="9">
        <location>
            <begin position="25"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="domain" description="Anaphase-promoting complex subunit 5" evidence="10">
        <location>
            <begin position="261"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00045696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF12862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OAG10436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="770" mass="86618" checksum="A6E61B2EEA57F74C" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CT63</accession>
    <name>A0A177CT63_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Spherulation-specific family 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1235898</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG09939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040304.1">
        <property type="nucleotide sequence ID" value="XM_018183865.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CT63"/>
    <dbReference type="GeneID" id="28767351"/>
    <dbReference type="InParanoid" id="A0A177CT63"/>
    <dbReference type="OrthoDB" id="5342184at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021986">
        <property type="entry name" value="Spherulin4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35040:SF9">
        <property type="entry name" value="4-LIKE CELL SURFACE PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14080)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12138">
        <property type="entry name" value="Spherulin4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG09939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="256" mass="28898" checksum="58083862A917CBF2" modified="2016-09-07" version="1">MATPIPTSEVLMPLYIYPDPGAWDPLFEAIAFNPTLRFVVIVNPNSGPGSEPWWPNADYLRDVPKLNACSNVRTVGYVSTAYCNRPIQEVYEDIRQYASWAKDKNSRSLGMNGIFFDETPNIFTENARNYLTAITQNVKNMGTLLGDGIVIHNPGTSIDERLAITGMDIATVAEVAYSDFHTRNFQNWLARSTLHRSNTSYMIHGFSEESVDDFVVHMLRGKARYIFVTERSTDMYHGFGASWKAFIAAMARNRTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CTA7</accession>
    <name>A0A177CTA7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1256524</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041128.1">
        <property type="nucleotide sequence ID" value="XM_018184633.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CTA7"/>
    <dbReference type="GeneID" id="28768119"/>
    <dbReference type="InParanoid" id="A0A177CTA7"/>
    <dbReference type="OrthoDB" id="3801272at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG10763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="220" mass="25176" checksum="0FB5705E58575FF6" modified="2016-09-07" version="1">MDTIGDFQYMSPTDYSKGQVPWSLQPEEFSAIIDTEQERLRECRRTWLQLVDTRIASYDLNGIKQSTQSSPLAKILSTPSNSSASNRVFQTTELLERILRQADSSAHLTALGVFHTWRDVALYIMKPSGAKYDFARPYPCPPVKFGDRVPRHLNWLPATAEELEWVVSDVLLDVIWGAKRGNVFRSVARFEYPNEPNIIETATLVESLWLQTRLPTRSLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CTJ7</accession>
    <name>A0A177CTJ7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Rap-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_1083035</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041219.1">
        <property type="nucleotide sequence ID" value="XM_018174000.1"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CTJ7"/>
    <dbReference type="GeneID" id="28757486"/>
    <dbReference type="InParanoid" id="A0A177CTJ7"/>
    <dbReference type="OrthoDB" id="19311at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033596">
        <property type="term" value="C:TSC1-TSC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032007">
        <property type="term" value="P:negative regulation of TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051056">
        <property type="term" value="P:regulation of small GTPase mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11210:FF:000007">
        <property type="entry name" value="Tuberous sclerosis 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11210">
        <property type="entry name" value="Rap/Ran-GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035974">
        <property type="entry name" value="Rap/Ran-GAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000331">
        <property type="entry name" value="Rap/Ran_GAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018515">
        <property type="entry name" value="Tuberin-type_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027107">
        <property type="entry name" value="Tuberin/Ral-act_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024584">
        <property type="entry name" value="Tuberin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10063">
        <property type="entry name" value="TUBERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10063:SF0">
        <property type="entry name" value="TUBERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11864">
        <property type="entry name" value="DUF3384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02145">
        <property type="entry name" value="Rap_GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03542">
        <property type="entry name" value="Tuberin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111347">
        <property type="entry name" value="Rap/Ran-GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50085">
        <property type="entry name" value="RAPGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rap-GAP" evidence="3">
        <location>
            <begin position="1177"/>
            <end position="1416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="323"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="655"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="959"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1417"/>
            <end position="1445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="332"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="655"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="668"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="692"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1422"/>
            <end position="1440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAG10854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="1476" mass="165854" checksum="98A4E7E54D8E869B" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CU73</accession>
    <name>A0A177CU73_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Actin, gamma</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CC84DRAFT_1161645</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the actin family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041161.1">
        <property type="nucleotide sequence ID" value="XM_018177793.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CU73"/>
    <dbReference type="SMR" id="A0A177CU73"/>
    <dbReference type="FunCoup" id="A0A177CU73">
        <property type="interactions" value="1220"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CU73"/>
    <dbReference type="GeneID" id="28761279"/>
    <dbReference type="InParanoid" id="A0A177CU73"/>
    <dbReference type="OrthoDB" id="5132116at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051286">
        <property type="term" value="C:cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030427">
        <property type="term" value="C:site of polarized growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd10224">
        <property type="entry name" value="ASKHA_NBD_actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000131">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000291">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000001">
        <property type="entry name" value="Actin, muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000058">
        <property type="entry name" value="Putative actin-related protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020902">
        <property type="entry name" value="Actin/actin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004001">
        <property type="entry name" value="Actin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00406">
        <property type="entry name" value="ACTINS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00432">
        <property type="entry name" value="ACTINS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01132">
        <property type="entry name" value="ACTINS_ACT_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAG10796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="375" mass="41639" checksum="0520E7883A359B80" modified="2016-09-07" version="1">MEEEVAALVIDNGSGMCKAGFAGDDAPRAVFPSIVGRPRHHGIMIGMGQKDSYVGDEAQSKRGILTLRYPIEHGVVTNWDDMEKIWHHTFYNELRVAPEEHPVLLTEAPINPKSNREKMTQIVFETFNAPAFYVSIQAVLSLYASGRTTGIVLDSGDGVTHVVPIYEGFALPHAISRVDMAGRDLTDYLMKILAERGYTFSTTAEREIVRDIKEKLCYVALDFEQEIQTASQSSSLEKSYELPDGQVITIGNERFRAPEALFQPSVLGLESGGIHVTTFNSIMKCDVDVRKDLYGNIVMSGGTTMYPGISDRMQKEITALAPSSMKVKIIAPPERKYSVWIGGSILASLSTFQQMWISKQEYDESGPSIVHRKCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CV84</accession>
    <name>A0A177CV84_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MYND-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CC84DRAFT_1113120</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041024.1">
        <property type="nucleotide sequence ID" value="XM_018175342.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CV84"/>
    <dbReference type="STRING" id="1460663.A0A177CV84"/>
    <dbReference type="GeneID" id="28758828"/>
    <dbReference type="InParanoid" id="A0A177CV84"/>
    <dbReference type="OrthoDB" id="432970at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052839">
        <property type="entry name" value="Mito_gene_expr_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046824">
        <property type="entry name" value="Mss51-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46920:SF1">
        <property type="entry name" value="PROTEIN MSS51 HOMOLOG, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20179">
        <property type="entry name" value="MSS51_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01360">
        <property type="entry name" value="ZF_MYND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="5">
        <location>
            <begin position="32"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAG10659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="472" mass="53997" checksum="51B9FA67E2B46C90" modified="2016-09-07" version="1">MPAKCRDRERVASSGVVDIPALPVGAIRGNLCFRCFSPSDDILKCSGCKRAYYCSAKCQKLDWKLMHKKHCAIFTTINNVEEEKYQASRTWNEYREFLLMMVRVIRNAAPKDEDLRHIIQAQAYCATCRRSAVQLASRKITLNRCKDCRLVFSCADCSPTPEHSASICAAFQNFRRIENFRINFFEDTGKATPITCTQFPRETHKPLANATGWFDYYTKISDKQQIEGRFKRDFSSVEEDFDRNGSDNEKDEAERMLMFLLYSTDSLTMPLTIISALEDLSWDRPHLTIHMLGATDRELTALANFEELLHLMPSVKSLHITAIGPGIPGPVNGTVIAKQSLDCCPPCKVDGRQRSISLYKGVYHEFVLEPTSEKPDLVVLFNSGWIDGDDTKSHWEPTIKALIDEKVPALFTTYNFEEAQHEQKRFKELGARFVTEVGENKWRGLVPTPEFIDEENGMWFNNAYRYVVQGKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CVE5</accession>
    <name>A0A177CVE5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phosphoglycerate mutase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_1253980</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG11525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041890.1">
        <property type="nucleotide sequence ID" value="XM_018184424.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CVE5"/>
    <dbReference type="FunCoup" id="A0A177CVE5">
        <property type="interactions" value="426"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CVE5"/>
    <dbReference type="GeneID" id="28767910"/>
    <dbReference type="InParanoid" id="A0A177CVE5"/>
    <dbReference type="OrthoDB" id="6509975at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07061">
        <property type="entry name" value="HP_HAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20963:SF23">
        <property type="entry name" value="3-PHYTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20963">
        <property type="entry name" value="MULTIPLE INOSITOL POLYPHOSPHATE PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008058646" evidence="3">
        <location>
            <begin position="20"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="386"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="388"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="413"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="430"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="454"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="492"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAG11525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="597" mass="64248" checksum="477850872AAACFF2" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CVG6</accession>
    <name>A0A177CVG6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1214169</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041247.1">
        <property type="nucleotide sequence ID" value="XM_018182607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CVG6"/>
    <dbReference type="STRING" id="1460663.A0A177CVG6"/>
    <dbReference type="GeneID" id="28766093"/>
    <dbReference type="InParanoid" id="A0A177CVG6"/>
    <dbReference type="OrthoDB" id="2520703at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG10882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="502" mass="58044" checksum="D575D785CEAC190C" modified="2016-09-07" version="1">MRSLPTELWEQIFSHLECPMPIDNWWYYGSQYDVSSLKDLASLSLACRTFQHIAQKFMYRTILAEAFSQEDSKVRDENKRLLARSMVQNPRLAAHARNVCLDSLRNGEDVECESLLRRADVGEREKRWLKMAMMKETKIGWNGRLLALMRNLQVVDVAVYRDAFDIAGMLSGRSDVEKIVQTIADLRETMRFTYSRRLEEEQLLRAIPTPFTDETLSDNALPHLKELRIRHRDSESGSISIADIEAVLLHPGLERLYLLGFDWTSFSLRKTRWPLHPNPAIRILDLRECFIDATGLRDVLTRFRNLHTLHILFGDSRRDDPSFDTDREQFDLEVDLSAMGAVLREHGQSLVSFELHTTGYSSYSSTDGQVDSLKEMTSLRHLKIAECDFTGHRNRWENDGVLALEDALPAGLETLYLHYDDRWFGPCSPDRGLFVMLGRTLRSGRFSELKEIKVERYLNDSTKELEPEIEGWEVRMTEAHFRMGVSSSGCMRLLIELTPVDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CWE4</accession>
    <name>A0A177CWE4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CC84DRAFT_1159048</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG11531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041896.1">
        <property type="nucleotide sequence ID" value="XM_018177124.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CWE4"/>
    <dbReference type="STRING" id="1460663.A0A177CWE4"/>
    <dbReference type="GeneID" id="28760610"/>
    <dbReference type="InParanoid" id="A0A177CWE4"/>
    <dbReference type="OrthoDB" id="5355161at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47660">
        <property type="entry name" value="TRANSCRIPTION FACTOR WITH C2H2 AND ZN(2)-CYS(6) DNA BINDING DOMAIN (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="9"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAG11531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="389" mass="43811" checksum="660B7621F634F7C7" modified="2016-09-07" version="1">MPAIGTGRSCVQCNDAKRRCDRNTPACRLCRRKNLDCVYPLLKPSNFVPITTTEEEYRPSDSDVLDLEDSSVEQLMSEALPDPTSDFVNVTALSLVPDPYAAWFAAPETFLVDHTPMPLPPNFKIRDLESFVAQVDTWLRDWVATGSNTFIHAHLYGDCFPSCLQVSFTTFSAYINRTPTNCKMVLQVVNDQATLLVSGSNTSGSVLKDLALIHALLVYQMIGLFDGDIRSRHLAELRVPFVSALLQRTLEKASETLIRQIEVEQLSIFPFDPVSPKELSWRSWIVSESLRRTWLITQGVIASYEGLKQGWAPCNGDVKFTTREGLWSADSAPQWARMCAERDVRFIGRFHAECLFEVAPEEVDVFAKVMLETVFGKEISVSWQLEAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CY38</accession>
    <name>A0A177CY38_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1211589</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG11968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042333.1">
        <property type="nucleotide sequence ID" value="XM_018182388.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CY38"/>
    <dbReference type="GeneID" id="28765874"/>
    <dbReference type="InParanoid" id="A0A177CY38"/>
    <dbReference type="OrthoDB" id="3791564at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG11968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="223" mass="25585" checksum="0C6B8B82D004AD9B" modified="2016-09-07" version="1">MYSLRSPRPWCMTRKPTQRDCVESGAIQAPETLPSSLRPTNIDTAFPSLLRRASCDAVCDYVPDTSSDQRYICCPSDADYDFRCDAPTKSDDESTRDTLVRFADVHSILCTPPPPTPPPHLTLLSTSSLPLTPLRLQPYGPRIPPWGSTEHLDRERRFRTDIRVLEDTLDEQFDKRERLRKEEEARNEKRRTEGEELRELVHEIYPEMEAGQTDRGCCLCAVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CY85</accession>
    <name>A0A177CY85_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">60S ribosomal protein L6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CC84DRAFT_1107989</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL6 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042383.1">
        <property type="nucleotide sequence ID" value="XM_018175186.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CY85"/>
    <dbReference type="FunCoup" id="A0A177CY85">
        <property type="interactions" value="1139"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CY85"/>
    <dbReference type="GeneID" id="28758672"/>
    <dbReference type="InParanoid" id="A0A177CY85"/>
    <dbReference type="OrthoDB" id="2436667at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13156">
        <property type="entry name" value="KOW_RPL6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000014">
        <property type="entry name" value="60S ribosomal protein L6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000915">
        <property type="entry name" value="60S_ribosomal_eL6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041997">
        <property type="entry name" value="Ribosomal_eL6_KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10715">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10715:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01159">
        <property type="entry name" value="Ribosomal_L6e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="114"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="19"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="130"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAG12018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="181" mass="20562" checksum="5E933E4BEA26BFAD" modified="2016-09-07" version="1">MTTQNFSKHYPAEDEAQMKKARKTAHPTKYRGSLQPGTVLILLAGRFRGKRVVLLRQLSQGVLLITGPFKSNGVPLRRVNHRYVIATSTTVDITGADNEVLDRVSEDEYWAREKKEGKGEDEFFQNGEAPSKKETDPQRIEDQKKVDKAIMSNIRKVPDLESYLAATFSLRGDEKPHEMVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CYT9</accession>
    <name>A0A177CYT9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Polysaccharide lyase family 20 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1227251</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018043038.1">
        <property type="nucleotide sequence ID" value="XM_018183606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CYT9"/>
    <dbReference type="GeneID" id="28767092"/>
    <dbReference type="InParanoid" id="A0A177CYT9"/>
    <dbReference type="OrthoDB" id="3889489at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025975">
        <property type="entry name" value="Polysacc_lyase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14099">
        <property type="entry name" value="Polysacc_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008058769" description="Polysaccharide lyase family 20 protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG12673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="288" mass="33068" checksum="8445C56D6C50D8F0" modified="2016-09-07" version="1">MLIQVTTLAFGLLPFAFATREFVNHGTTSGWPSTWIDPNTKGYVENSTSAFYGKSQSLKFGQEYLGSSYEGRYHAEKIYSNGYKRDEEKYYGFAFRLHSEWEFDPQSYNLAQFGANFNDIKWNGESCDDFSPTTMIWLNQTKLFARTKHGQMIKGQKCPPDDQKWNCDLGPNCQVTESFQLKSETSSIGEIKAGVWYRLTFRVKWKSDDTGIFQAWLNGTQVADKSKLKTTLLDDHRDYEFRVGLYANSWHDEKKMVGSQPKRQLWIDEIGVGSTFADADPDDIKKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CYY9</accession>
    <name>A0A177CYY9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1227309</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018043088.1">
        <property type="nucleotide sequence ID" value="XM_018183608.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CYY9"/>
    <dbReference type="GeneID" id="28767094"/>
    <dbReference type="InParanoid" id="A0A177CYY9"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="161"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG12723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="344" mass="36878" checksum="B52FA29567965E63" modified="2016-09-07" version="1">MVDAPACPTRFCCVGPSAPFPTPVAYRCVAPLLGPLPSLFWPPSLSDMQPYSRGASAPVCHWPTVPTRFRGRGFALEASLRSAAPGATGKQTVVRSDRLPSMRSSHRRSSGGSPASVTIARPRPVHASVTTSTLPAVDSLLDRLNQARHDSADCASSGQLQPPQAAPTSSVASVSATSLQRSALDSSRRPGSRKHERGVWRCDDVFPMPPACLVSYQRRSATPQRPFSRRQCESACHCVLCLTSNQPGPEPAPLCDSTPMSSRNILPSAQSPGAIKIYYLPTLMLGKLASALARFRNIPPLRDCATCKYHVFYVTAVSPDHTGLAERIIKFPHDSGSALAEAIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CZL0</accession>
    <name>A0A177CZL0_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Histidine--tRNA ligase, mitochondrial</fullName>
            <ecNumber evidence="3">6.1.1.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Histidyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CC84DRAFT_1076977</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the aminoacylation of histidyl-tRNA in both the cytoplasm and the mitochondrion.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>tRNA(His) + L-histidine + ATP = L-histidyl-tRNA(His) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17313"/>
            <dbReference type="Rhea" id="RHEA-COMP:9665"/>
            <dbReference type="Rhea" id="RHEA-COMP:9689"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78527"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.21"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.21" evidence="3"/>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042926.1">
        <property type="nucleotide sequence ID" value="XM_018173734.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CZL0"/>
    <dbReference type="FunCoup" id="A0A177CZL0">
        <property type="interactions" value="861"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CZL0"/>
    <dbReference type="GeneID" id="28757220"/>
    <dbReference type="InParanoid" id="A0A177CZL0"/>
    <dbReference type="OrthoDB" id="1906957at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004821">
        <property type="term" value="F:histidine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990825">
        <property type="term" value="F:sequence-specific mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006427">
        <property type="term" value="P:histidyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00773">
        <property type="entry name" value="HisRS-like_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00859">
        <property type="entry name" value="HisRS_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.800:FF:000015">
        <property type="entry name" value="Histidyl-tRNA synthetase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000021">
        <property type="entry name" value="Probable histidine--tRNA ligase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041715">
        <property type="entry name" value="HisRS-like_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004516">
        <property type="entry name" value="HisRS/HisZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033656">
        <property type="entry name" value="HisRS_anticodon"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11476:SF7">
        <property type="entry name" value="HISTIDINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11476">
        <property type="entry name" value="HISTIDYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13393">
        <property type="entry name" value="tRNA-synt_His"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001549">
        <property type="entry name" value="His-tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 17" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="16">
        <location>
            <begin position="16"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="304"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="308"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="85"/>
            <end position="87"/>
        </location>
        <ligand>
            <name>L-histidine</name>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>L-histidine</name>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>L-histidine</name>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>L-histidine</name>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="283"/>
        </location>
        <ligand>
            <name>L-histidine</name>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="287"/>
            <end position="288"/>
        </location>
        <ligand>
            <name>L-histidine</name>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00058343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00067413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR001549-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="OAG12561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="507" mass="56531" checksum="6D912B189B9C3CB4" modified="2016-09-07" version="1">MGKEGKGNFQLKTPKGTRDWSGTDVVLREQIFTTISNVFKRHGGVTIDTPVFELKDTLTGKYGEDSKLIYDLADQGGEICSLRYDLTVPFARFCAQNAVQNIKRYHIAKVYRRDQPAMTKGRMREFYQCDFDIAGQFDPMLPDAEILRIVKEVFEELPEWKGKFTIKINHRKILDGIFQICGVPEDKIRTISSAVDKLDKSPWEEVRREMVEDKGLAPEVADKIWTYAQLKGGKDVVEKLQAMPEVVANESAKQGLENMALLCDYLEIFEVMPALSVDMSLARGLDYYTGVIYEVVTEGSAPSASAKDVAKKEEKQKKQKKSTDPDEDRSNDPTIGVGSVAAGGRYDELVGMFSGKPIPCVGISFGVDRIFSITKARLDKNREATALRPTEVDVFIMAFGGGKDFTGMLPERMAVAKELWDAGIKAEYLWKAKPKLQNQFKAAENGKVPWAIILGDDELKAGKIKIKEMGLPDGHPEKDGVVVEKNRLVEEIQSRLAGKASLPVRSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CZQ9</accession>
    <name>A0A177CZQ9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Zn-dependent exopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_1227438</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M20A family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018043161.1">
        <property type="nucleotide sequence ID" value="XM_018183612.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CZQ9"/>
    <dbReference type="STRING" id="1460663.A0A177CZQ9"/>
    <dbReference type="GeneID" id="28767098"/>
    <dbReference type="InParanoid" id="A0A177CZQ9"/>
    <dbReference type="OrthoDB" id="3064516at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050072">
        <property type="entry name" value="Peptidase_M20A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43808">
        <property type="entry name" value="ACETYLORNITHINE DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43808:SF8">
        <property type="entry name" value="PEPTIDASE M20 DIMERISATION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="Bacterial exopeptidase dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008058805" evidence="6">
        <location>
            <begin position="18"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M20 dimerisation" evidence="7">
        <location>
            <begin position="189"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAG12796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="417" mass="45787" checksum="7706E59C0C1A3B83" modified="2016-09-07" version="1">MRSSSLLGVLLPAWVAAQNLSLQHPELFSLHWRMLEQNSTSGFETPMVDFLSGYLEDKGLTVELQPVQNPILAYNVRRQNILAYIGSNRTCRLILNSHTDVVPPYFPPHDNDTDVFGRGANDAKGSIACQVTAFLELKDAGVIKEGDVCLMYDVGEEQYGDGMRTFVDSLTYTPEWILTGEPTESFQATGHKGSININVTAIGDTAHSSVPQYGRNAILELMNFIPSLLNLTSIFPYDDFHGNTTLSLSSIKGGTISNQVADRAEAIVNSRVSVPAKEIWDIITEQVGNVSNIILSRVSASSNPLAMDVIEGWLPKKIMPYGTDLGAWTVNNTKLLLGVGSIATAHSAHEVVSKQEMIDMVGHYKEFVQGILNGTLVPIRNGTFPSSYPLETNTSNLTKREIAMQDYEARRYGGCMH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CZW0</accession>
    <name>A0A177CZW0_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CC84DRAFT_114891</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042755.1">
        <property type="nucleotide sequence ID" value="XM_018176652.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CZW0"/>
    <dbReference type="STRING" id="1460663.A0A177CZW0"/>
    <dbReference type="GeneID" id="28760138"/>
    <dbReference type="InParanoid" id="A0A177CZW0"/>
    <dbReference type="OrthoDB" id="3801175at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45969:SF69">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12190)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45969">
        <property type="entry name" value="RING ZINC FINGER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="86"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="13"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="131"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="19"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="31"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="141"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="153"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="256"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAG12390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="268" mass="28402" checksum="D896DAA8F9ABA1BC" modified="2016-09-07" version="1">MAPYADKSAFLANGLKPYHPSPPHTPPASPPATEATSGPLFGPVAADTPPTPPPASPTTDLPFNIVVTDTPADPASCSAAPSEATCPICLDPLSLTLSAVRIRACTHAYHEACLSLWVDRRNTCPACRSELFTAPPRPRQRAQPGSITAADLPPRRPRAEARRPASRRWTSAVKRPRAGHWGENGDWVEVRADMPGPLDDTPPARRAGVTRMSLHPGASEGAGRQGGRFIPGRRRGPRGSGRDVSPEEVEDGTGSAGWTGQSSRATLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177D0H4</accession>
    <name>A0A177D0H4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_1135111</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042814.1">
        <property type="nucleotide sequence ID" value="XM_018176046.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177D0H4"/>
    <dbReference type="STRING" id="1460663.A0A177D0H4"/>
    <dbReference type="GeneID" id="28759532"/>
    <dbReference type="InParanoid" id="A0A177D0H4"/>
    <dbReference type="OrthoDB" id="4456959at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF23">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="29"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="99"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="689"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="727"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="99"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="689"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="727"/>
            <end position="742"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAG12449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="839" mass="94172" checksum="990ED35B0E000D18" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177D152</accession>
    <name>A0A177D152_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_185325</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG13191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018043556.1">
        <property type="nucleotide sequence ID" value="XM_018185503.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177D152"/>
    <dbReference type="STRING" id="1460663.A0A177D152"/>
    <dbReference type="GeneID" id="28768989"/>
    <dbReference type="InParanoid" id="A0A177D152"/>
    <dbReference type="OrthoDB" id="3251507at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027796">
        <property type="entry name" value="OTT_1508_deam-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42037">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42037:SF1">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14441">
        <property type="entry name" value="OTT_1508_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG13191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="486" mass="55566" checksum="24CE2ACC4AD9CABA" modified="2016-09-07" version="1">MVKEKKRRKESLAANLPMSSSKRPRFDKRGRQLSRFYEPLVLLYTLGRTRGEHMRDILCDGTNISNLPHKYLIRRFLCSLAYVCDYDKGGDTVTAIGLESRPHGYIFWIASNSNQTTKTVPFLMWLLGHMYQVSIEATAIVPEQVDDLGAKCIDFAVPRIKAYRNHLKPVLRRCLGHLDNQSHNGNEAHGLSEWLQNWNDQRGSEELCHFSYQERKSEFMQLLAKLGTEPSYKSNKDAIHHAFSSARHLIGRLGHHFRVANELLFCASRLSDILHGFEVRSIPIHTRSAIPPSDGKTTLDSVISRMLPSQSADVERYQSNLAEMDAKYQLSRRFLDNYRDPDLNPRVHAEIQVLEHFYVGGLRFVESDAFVACSKPACFCCLLYFRAHPGHFVEPTSHQKIYLNWRPPDLDAQMAIIRENHQRDILNAMTKSIRKEAFRQINEKIPPHARHPESLTGITESASSPSTLELVSITCISSSSASFHRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177D164</accession>
    <name>A0A177D164_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1201793</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018043277.1">
        <property type="nucleotide sequence ID" value="XM_018181739.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177D164"/>
    <dbReference type="STRING" id="1460663.A0A177D164"/>
    <dbReference type="GeneID" id="28765225"/>
    <dbReference type="InParanoid" id="A0A177D164"/>
    <dbReference type="OrthoDB" id="3520229at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG12912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="177" mass="17036" checksum="BA1772A2FCA951D5" modified="2016-09-07" version="1">MSSPASSAVSSAVSSAVSSAPAPSNSACAQTSFTEFPTKDAACAVGGTSGVPDNYEDILKGCCKSAPVETWGSDCALWCLAADQSIADLQKCWQDGGVKAGSIQCNQPNNATATGKVSGASSSGSGAKETGSQTSGGASSSTSSPGAAPAVVPQGVSKAGLGMLAMVLGSAVFGAML</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BUD9</accession>
    <name>A0A177BUD9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Lysine-specific metallo-endopeptidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CC84DRAFT_1191530</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M35 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441563">
        <property type="protein sequence ID" value="OAF99062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029428.1">
        <property type="nucleotide sequence ID" value="XM_018181189.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BUD9"/>
    <dbReference type="GeneID" id="28764675"/>
    <dbReference type="InParanoid" id="A0A177BUD9"/>
    <dbReference type="OrthoDB" id="5357726at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050414">
        <property type="entry name" value="Fungal_M35_metalloproteases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37016">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37016:SF3">
        <property type="entry name" value="NEUTRAL PROTEASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008057329" description="Lysine-specific metallo-endopeptidase domain-containing protein" evidence="9">
        <location>
            <begin position="21"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="21"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="22"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAF99062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="287" mass="31771" checksum="02D13A039288FC63" modified="2016-09-07" version="1">MYFFSLPFLALSGSIHGAFASPTPSSSQDLSKSITKRGEPNTGADFDENEEPKPNTLEKTETAINDALELASYVTSYIDDDNDIYPHYFDEADRAEIKRIFVDLTNGQKGNDYLDKILIQKSDDDNLCDDQTLAYSNDEDTENPYIVLCPNSFKKKAVTALPSKDIDDEDALDFYTVCAKDGGDLGDTVSYRMNTLGMTLLHEYMHMDSMIKASFGSIVDNPNGNDGYGPVNVYDKIPKDQARLNADSYAYYASHVLWTALCQQDFGAPRPGTDDQDPDCGATVCKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2023-06-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BV20</accession>
    <name>A0A177BV20_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_429851</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441566">
        <property type="protein sequence ID" value="OAF98571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018028937.1">
        <property type="nucleotide sequence ID" value="XM_018186215.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BV20"/>
    <dbReference type="GeneID" id="28769701"/>
    <dbReference type="InParanoid" id="A0A177BV20"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAF98571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="159" mass="17882" checksum="782FDD5ECFCD67BE" modified="2016-09-07" version="1">MIHIYRCGEFTFSHNMWDAGYPTKYRLQTLATGKTLSEQTITSIAVSEVLPGSQTRFPGLGFLESPSSGALHTHAHQKSREVACTRYQARPSQEAATSARRPDMRKKHFEAHCALCVYYESKPSPSWRQNATLPYPVGVWERLERGFPLAKSSYCLAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BW32</accession>
    <name>A0A177BW32_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SET domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1158638</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441566">
        <property type="protein sequence ID" value="OAF98576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018028942.1">
        <property type="nucleotide sequence ID" value="XM_018177057.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BW32"/>
    <dbReference type="STRING" id="1460663.A0A177BW32"/>
    <dbReference type="GeneID" id="28760543"/>
    <dbReference type="InParanoid" id="A0A177BW32"/>
    <dbReference type="OrthoDB" id="265717at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd20071">
        <property type="entry name" value="SET_SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053185">
        <property type="entry name" value="SET_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47332">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47332:SF2">
        <property type="entry name" value="SET-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SET" evidence="1">
        <location>
            <begin position="6"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAF98576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="325" mass="36508" checksum="BB3A3663371C7750" modified="2016-09-07" version="1">MQGTPEKIYAVEHIPGKGRGVVALTDITKGTRVMSEKPIITISQNITSIQQLRTCILDQVSSLSKYDRQEFFSMANVYGGINPLETWYGILRTNALPMGPNLDTGGIFLQACRINHACDGNAVHCWNENLNQLTIHAIRDIRKGEEITISYLATLRNRQARQDELLHNFGFLCACQLCCLPLGESKCNDAALDRIHAIDDIIEKRGIKGLVKPAQKMLSYVDEQVRIWKKTTIAEGGLTRAYPDAFQIAVANGDLARARVFAERCLRLYETSLGNDSPDVAEYGAFVVNPATHKYYGMSTKWATTVDEIPYSLDTQSFEDWLWRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BWH5</accession>
    <name>A0A177BWH5_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">EKC/KEOPS complex subunit CGI121</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">EKC/KEOPS complex subunit cgi121</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CC84DRAFT_1049169</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. CGI121 acts as an allosteric effector that regulates the t(6)A activity of the complex. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. The complex is required for efficient recruitment of transcriptional coactivators. CGI121 is not required for tRNA modification.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the CGI121/TPRKB family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441564">
        <property type="protein sequence ID" value="OAF98857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029223.1">
        <property type="nucleotide sequence ID" value="XM_018173449.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BWH5"/>
    <dbReference type="FunCoup" id="A0A177BWH5">
        <property type="interactions" value="493"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177BWH5"/>
    <dbReference type="GeneID" id="28756935"/>
    <dbReference type="InParanoid" id="A0A177BWH5"/>
    <dbReference type="OrthoDB" id="329139at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000408">
        <property type="term" value="C:EKC/KEOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002949">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2380.10">
        <property type="entry name" value="CGI121/TPRKB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013926">
        <property type="entry name" value="CGI121/TPRKB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036504">
        <property type="entry name" value="CGI121/TPRKB_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15840">
        <property type="entry name" value="CGI-121 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15840:SF10">
        <property type="entry name" value="EKC_KEOPS COMPLEX SUBUNIT TPRKB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08617">
        <property type="entry name" value="CGI-121"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143870">
        <property type="entry name" value="PF0523-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="166"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAF98857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="203" mass="21795" checksum="15897DC2CE05B3A9" modified="2016-09-07" version="1" fragment="single">AHIHTLTLPHYPTHPVHIALFCSVTNAPHLRSQLLSSNSAFDYAFLDATVLLSPTHLLLAAQLALHAHLTGRGRTRTPHSELVFRLHPNNNIGEAYRKVGMGDESGHVLVVKFGGLEEDVTAESVAKHLGMVVEGESVEIAEEMGEVGMFADVGKIRKIYKLGEGGAKGKGKKGTDVNGDGTARDERKDMESVILGTMALKGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BWI9</accession>
    <name>A0A177BWI9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DUF202 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CC84DRAFT_1105555</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441564">
        <property type="protein sequence ID" value="OAF98867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029233.1">
        <property type="nucleotide sequence ID" value="XM_018175102.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BWI9"/>
    <dbReference type="GeneID" id="28758588"/>
    <dbReference type="InParanoid" id="A0A177BWI9"/>
    <dbReference type="OrthoDB" id="199599at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003807">
        <property type="entry name" value="DUF202"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052053">
        <property type="entry name" value="IM_YidH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34187:SF2">
        <property type="entry name" value="DUF202 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34187">
        <property type="entry name" value="FGR18P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02656">
        <property type="entry name" value="DUF202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="126"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="166"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="DUF202" evidence="8">
        <location>
            <begin position="65"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAF98867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="192" mass="21129" checksum="10AF48C6AC00D2C1" modified="2016-09-07" version="1" fragment="single">NSETNVTATHESTEEVVERSPAQQHIGNIERRTGETVKRDAGRWSRFWGEWGSVELENKGSVARYYLALERTFLAWLRTSLSLASIGVAITQLFRLNCSLEFDTSKKPTNATADSRTHSQYEMRRLGKSLGTAFIGVSILMLFVGFHRYFEAQHYVIQGKFPASRGSIIVGSALVVGLIVGSLAAIFAAGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BWQ9</accession>
    <name>A0A177BWQ9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Uracil permease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_1102859</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441560">
        <property type="protein sequence ID" value="OAF99923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030289.1">
        <property type="nucleotide sequence ID" value="XM_018174986.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BWQ9"/>
    <dbReference type="GeneID" id="28758472"/>
    <dbReference type="InParanoid" id="A0A177BWQ9"/>
    <dbReference type="OrthoDB" id="2018619at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015205">
        <property type="term" value="F:nucleobase transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11482">
        <property type="entry name" value="SLC-NCS1sbd_NRT1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.4160.10:FF:000001">
        <property type="entry name" value="Uracil permease, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4160.10">
        <property type="entry name" value="Hydantoin permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045225">
        <property type="entry name" value="Uracil/uridine/allantoin_perm"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30618">
        <property type="entry name" value="NCS1 FAMILY PURINE/PYRIMIDINE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30618:SF0">
        <property type="entry name" value="PURINE-URACIL PERMEASE NCS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="104"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="142"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="200"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="227"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="307"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="358"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="402"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="424"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="476"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="514"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAF99923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="583" mass="63790" checksum="F16ED4649CAB9DAA" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BWX2</accession>
    <name>A0A177BWX2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1132384</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441564">
        <property type="protein sequence ID" value="OAF98866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029232.1">
        <property type="nucleotide sequence ID" value="XM_018175931.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BWX2"/>
    <dbReference type="GeneID" id="28759417"/>
    <dbReference type="InParanoid" id="A0A177BWX2"/>
    <dbReference type="OrthoDB" id="88410at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34724">
        <property type="entry name" value="OS12G0596101 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34724:SF2">
        <property type="entry name" value="OS12G0596101 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAF98866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="53" mass="6082" checksum="9A6C24EB305C93DF" modified="2016-09-07" version="1">MCFPAKCKVCNKASWQGCGQHVPRVMKQIPSEEWCTCEPQVEREGEKYPPKAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BXI5</accession>
    <name>A0A177BXI5_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">Protein phosphatase PP2A regulatory subunit B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CC84DRAFT_414773</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Phosphatase 2A affects a variety of biological processes in the cell such as transcription, cell cycle progression and cellular morphogenesis, and provides an initial identification of critical substrates for this phosphatase. The regulatory subunit may direct the catalytic subunit to distinct, albeit overlapping, subsets of substrates.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the phosphatase 2A regulatory subunit B family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441563">
        <property type="protein sequence ID" value="OAF99039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029405.1">
        <property type="nucleotide sequence ID" value="XM_018186117.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BXI5"/>
    <dbReference type="FunCoup" id="A0A177BXI5">
        <property type="interactions" value="733"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177BXI5"/>
    <dbReference type="GeneID" id="28769603"/>
    <dbReference type="InParanoid" id="A0A177BXI5"/>
    <dbReference type="OrthoDB" id="6274823at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005935">
        <property type="term" value="C:cellular bud neck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005934">
        <property type="term" value="C:cellular bud tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000159">
        <property type="term" value="C:protein phosphatase type 2A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000705">
        <property type="term" value="P:achiasmate meiosis I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071475">
        <property type="term" value="P:cellular hyperosmotic salinity response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045143">
        <property type="term" value="P:homologous chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016237">
        <property type="term" value="P:microautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044818">
        <property type="term" value="P:mitotic G2/M transition checkpoint"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001100">
        <property type="term" value="P:negative regulation of exit from mitosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010515">
        <property type="term" value="P:negative regulation of induction of conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031030">
        <property type="term" value="P:negative regulation of septation initiation signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000786">
        <property type="term" value="P:positive regulation of autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010971">
        <property type="term" value="P:positive regulation of G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905477">
        <property type="term" value="P:positive regulation of protein localization to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900182">
        <property type="term" value="P:positive regulation of protein localization to nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061586">
        <property type="term" value="P:positive regulation of transcription by transcription factor localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090266">
        <property type="term" value="P:regulation of mitotic cell cycle spindle assembly checkpoint"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000174">
        <property type="entry name" value="Protein phosphatase PP2A regulatory subunit B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000189">
        <property type="entry name" value="Protein phosphatase PP2A regulatory subunit B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000009">
        <property type="entry name" value="PP2A_PR55"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018067">
        <property type="entry name" value="PP2A_PR55_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11871">
        <property type="entry name" value="PROTEIN PHOSPHATASE PP2A REGULATORY SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037309">
        <property type="entry name" value="PP2A_PR55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00600">
        <property type="entry name" value="PP2APR55"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01024">
        <property type="entry name" value="PR55_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01025">
        <property type="entry name" value="PR55_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 7" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="403"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="407"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00055525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00067298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU331113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAF99039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="483" mass="54270" checksum="73E4D476772F1432" modified="2016-09-07" version="1">MVEAEGNPTTWKFTQCFGDKGDVEDITEADIISTVEFDQTGNYLATGDKGGRVVLFERNETKKTCEYKFHTEFQSHEPEFDYLKSLEIEEKINKIKWCRRQNASHYLLSTNDKTIKLWKVFEKSLKVVAENNLSHELTPGGGVAGGGGPVRNPNVNFRSAADLKLPRLTHHDTVVAAVPRKTYANAHAYHINSISVNSDGETFISSDDLRINLWNLNIQDQSFNIVDIKPANMEELTEVITAAEFHPQSCNWFMYASSKGTIKLADMRESALCDQHAKQFEQEEDPSSRSFFSEIISSISDVRFSHDGRYILSRDYLTVKIWDVNMERTPIKTIPIHEHLRPRLCDTYENDSIFDKFEVVFSGDAKNVMTGSYNNNFMIYPSDPEKDTEVVLQADKSAFKAKKVGIPTPMNSSTSPTSSSAKKGGSRAGSPAAGAAGQGQRMRKETDADQIDFNKKILHMSWHPFEDSIAIAATNNLFVFSAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BYE7</accession>
    <name>A0A177BYE7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1169223</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441561">
        <property type="protein sequence ID" value="OAF99708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030074.1">
        <property type="nucleotide sequence ID" value="XM_018179605.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BYE7"/>
    <dbReference type="GeneID" id="28763091"/>
    <dbReference type="InParanoid" id="A0A177BYE7"/>
    <dbReference type="OrthoDB" id="3794732at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAF99708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="215" mass="24340" checksum="45B98EC90DFE4FD7" modified="2016-09-07" version="1">MIRVIFAPKEAGLINAEHVSKAQQEKGLSVPLNLLRSSSQFLKAATKPEWDDLRDDGRTVTPRCDPVLFKTYVHWLHSGTIPRPDDNVPDYKDFVFLSKLYVLGEYLMDVIFKNAIIEAIIAISIKEKYCPIGEAVRIIYEGTSAGSPARRLMTDFCASNANDDPSWTDEFQNCPHEFLVDTMKALVSARPRTSGEYPLDIKYEHYQEPFPTLAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BYH3</accession>
    <name>A0A177BYH3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Fucose-specific lectin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1156288</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441560">
        <property type="protein sequence ID" value="OAG00196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030561.1">
        <property type="nucleotide sequence ID" value="XM_018176969.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BYH3"/>
    <dbReference type="STRING" id="1460663.A0A177BYH3"/>
    <dbReference type="GeneID" id="28760455"/>
    <dbReference type="InParanoid" id="A0A177BYH3"/>
    <dbReference type="OrthoDB" id="3923199at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.70">
        <property type="entry name" value="Fucose-specific lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89372">
        <property type="entry name" value="Fucose-specific lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="135"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG00196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="554" mass="61113" checksum="6447421692F850EB" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BYZ5</accession>
    <name>A0A177BYZ5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1181306</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441561">
        <property type="protein sequence ID" value="OAF99851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030217.1">
        <property type="nucleotide sequence ID" value="XM_018180551.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BYZ5"/>
    <dbReference type="GeneID" id="28764037"/>
    <dbReference type="InParanoid" id="A0A177BYZ5"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAF99851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="399" mass="43602" checksum="AC1DC32771B04691" modified="2016-09-07" version="1">MDMHSVKGLPTVHRCRRVEYLETGIGIPTILGVRTAPASTAIATLGQVMNFVTVLTTDKLFRWMPVEVLGAGMLEIAEDINEKDHERRKATIVHSLPSILFILAVVGEILGLIGSVFGVVGDSVLDLQRLVEDKLNLLGNFGLVLTPLALTDVVRMSKGLGSCVGGIRRPQAERGRLFCTTARRESLGRIAPDDATDQRHAFSQTSQQACTHSVSTRTSAGSLASRQVTTAAPAAFSRHTISLTDFSWLVPRARPIKAAKSVRRSFLAKGIGLVCFFDGGHPLSARHPDMQLHNAFLPNSPTATSDTRLEQAQPDLASGYLLSRDKGRAPVPSTRPKDQIRIGVVRSPRTDRLRSLDVTARLFLPYSTTQRKTHDLVWKVIAQGARHGTVMNEHLRALH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2023-06-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BZ17</accession>
    <name>A0A177BZ17_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_363478</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441560">
        <property type="protein sequence ID" value="OAG00211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030576.1">
        <property type="nucleotide sequence ID" value="XM_018185922.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BZ17"/>
    <dbReference type="GeneID" id="28769408"/>
    <dbReference type="InParanoid" id="A0A177BZ17"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG00211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="228" mass="25269" checksum="66F99447C60DA380" modified="2016-09-07" version="1">MPRLAAPPCQHLPNPCLVFHVRACGLVIPAPRLSSARMRAWTLSRCRLLGEGEHRRYSNRSSVKPYSNPVRSSTDCYTYDWQRPRLALGVHVAANGRPCSLLSSMRDQSWTSVTSGAYSTPRPVEPRLVDWVWTQAALRAATHVYLAQERGRLGGENAKQVRDGELPCHETKANVNIRNSHSPVLAISIFMAPLISFVPLSCTYDSSTHVTLHVYVPLVQSSIAVSAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BZ80</accession>
    <name>A0A177BZ80_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mid2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1180846</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441560">
        <property type="protein sequence ID" value="OAG00019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030384.1">
        <property type="nucleotide sequence ID" value="XM_018180512.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BZ80"/>
    <dbReference type="STRING" id="1460663.A0A177BZ80"/>
    <dbReference type="GeneID" id="28763998"/>
    <dbReference type="InParanoid" id="A0A177BZ80"/>
    <dbReference type="OrthoDB" id="5215637at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="221"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="284"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG00019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="317" mass="34608" checksum="8B54582E83B2FA7D" modified="2016-09-07" version="1">MDTAPNGTCYSITGLASPFNDYTYVPCNLTAIENGQHSACCASGDTCLTNGLCKYNSPTPVRNFNTYWRIGCTDPTYQDSSCPKQCKNRENVERHVHIVFECPGDGQWCCGTGANTDYENTMTVNTTCCNIPDLAFRDEVRQAYTTAKSDWRSVIDIRTFEALAKSTAIDAASTATASSTEQSVRHTSTSSHTSILLATATASTSPSPSLSTPPSNQNTTALGVGLGIGIAILVAVLALLTFLLYRHRRHRKTQHERMAELAETQEDVRHAFSHAFAVEKSGREVPAELSAERGVHEMGRPDSWRTGDDGKGDEFYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C092</accession>
    <name>A0A177C092_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1168242</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441558">
        <property type="protein sequence ID" value="OAG01063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031428.1">
        <property type="nucleotide sequence ID" value="XM_018179351.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C092"/>
    <dbReference type="STRING" id="1460663.A0A177C092"/>
    <dbReference type="GeneID" id="28762837"/>
    <dbReference type="InParanoid" id="A0A177C092"/>
    <dbReference type="OrthoDB" id="408373at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052897">
        <property type="entry name" value="Sec-Metab_Biosynth_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37017:SF3">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37017">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="7"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG01063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="319" mass="35090" checksum="28D1F9223FEEFE6B" modified="2016-09-07" version="1">MAEKPTLVFIPGAWHKPKCYEKVIKSLQDEHGFTCISITLPSTNGDPYATFKDDVDAARNGLIAELTAGRDAVVIAHSYGGQVGNSCIKGLTRPRSDIPQSASSKGFVIALVLIASGFSFTGLAFMDPLFGIPPPFWRVNKETGFAELTSDNRELFYHDLPREEGEYWVSQLTTQSLKSLFEGGQHVYAGWKDVPTWYIGTIEDRGLPVVIQRVQVGVARGQGGVVHHMELPTSHSPFLSMPVEIVAAILQAVKMAGRSQELSARNDAVLKKSYVPAVKIFAPRTWVRFGLPLAIGRLLGWGFWSYHGLKGIFTSRSQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C0D3</accession>
    <name>A0A177C0D3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CC84DRAFT_1168951</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441560">
        <property type="protein sequence ID" value="OAG00070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030435.1">
        <property type="nucleotide sequence ID" value="XM_018179536.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C0D3"/>
    <dbReference type="STRING" id="1460663.A0A177C0D3"/>
    <dbReference type="GeneID" id="28763022"/>
    <dbReference type="InParanoid" id="A0A177C0D3"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11059">
        <property type="entry name" value="CYP_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF96">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE STCB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0349">Heme</keyword>
    <keyword evidence="5 6 7" id="KW-0408">Iron</keyword>
    <keyword evidence="3 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008057609" evidence="8">
        <location>
            <begin position="24"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="6">
        <location>
            <position position="446"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAG00070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="500" mass="55684" checksum="92BF2487F92CFC5E" modified="2016-09-07" version="1">MFSPVLILLLAIAAFFLKSLIRGVRSPLAHIPGPWHTRFTNISLRIATIKGRRIHHVESLHQRYGPIVRLSPTQLDVSELSAFSQIHRIGSHFHKSPWYESTHRGRKPGIFAMQDPGQHAQRRRLFARAFSYTSISTHWEAVIREKVSLAVQRIRESAIEGGRDQSMATNDISSMNPSHGADVLKWWTLMATDVIAHLSFGESFQMLELGQQTAYIDALQSANLSSVLRSEAPLVWHIAYWVPFGKLHAITQAEKVVLKYGARAIQNMRREGGGIKNLFGQMEAAAEKDDGSITDDEIETEAGNLIVAGSDTTAVTLTYLVWAVLKQPALQKELEAEVAKLSDALRLEELIQNMPLLNSVMEETLRLYGAAPGALPRSVPKEGAVFGGYQIPGGVEVSTQAYTIHRHPDLWTDPLSFNGYRFLDKSTMTSAQKTAMHPFGAGSRSCIGLHLAWMELRLGAAMFFRDCRGARLAPCMTDEMMEVDNRFLISPKGHCCFIVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C1M1</accession>
    <name>A0A177C1M1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_200933</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441557">
        <property type="protein sequence ID" value="OAG01543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031908.1">
        <property type="nucleotide sequence ID" value="XM_018185566.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C1M1"/>
    <dbReference type="GeneID" id="28769052"/>
    <dbReference type="InParanoid" id="A0A177C1M1"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG01543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="277" mass="31049" checksum="C749BBAA968D91C6" modified="2016-09-07" version="1">MTHPGNDAADPGSRRNGRRHLGPHQLGFACLYSRRFEKAAWKKAALRTKPARLQGKVASLARRRVMSKTLAQRVLSRSPSHSSWYGTSEMVMSLRTPRVRRSTLPGFCRGPQSSNPPLADSRQCRIRRVASSSLAMPGSGDASRVITRICATAHYTPYTVRRDTKKSSTRLSLCHVTSERAEGTPYQQEHNIGPRGKKRFSAHHELDHHSHRQHQDLSARRLSCSNHPPCHSRLAAHEECPARAPVAHRSERCLWPGSVGSCQTLRMFSHRLPAPLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C1R0</accession>
    <name>A0A177C1R0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1221344</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441558">
        <property type="protein sequence ID" value="OAG00772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031137.1">
        <property type="nucleotide sequence ID" value="XM_018183264.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C1R0"/>
    <dbReference type="GeneID" id="28766750"/>
    <dbReference type="InParanoid" id="A0A177C1R0"/>
    <dbReference type="OrthoDB" id="5427664at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="49"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG00772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="112" mass="12858" checksum="DFAB1E952033D74D" modified="2016-09-07" version="1">MINTTSLNPVDRWLREKVTKFMSHRVSDKNKELWVESLTKVLLGLSDQQLVTCLAVFVVAIVKMVIGSITAGVFWDEYLARMGKLKEYDEEHDGYENSSRWSSDLGPYRASQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C2Y8</accession>
    <name>A0A177C2Y8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1221667</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441558">
        <property type="protein sequence ID" value="OAG01137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031502.1">
        <property type="nucleotide sequence ID" value="XM_018183295.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C2Y8"/>
    <dbReference type="GeneID" id="28766781"/>
    <dbReference type="InParanoid" id="A0A177C2Y8"/>
    <dbReference type="OrthoDB" id="5423681at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="132"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG01137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="240" mass="25939" checksum="2A24AC7AE05E6830" modified="2016-09-07" version="1">MHHRYLAALKGKDQFQYANNTNTNLHDQSTRTYYINGNFNDNGSSRHNQPLLTYKEPWNKRHKWMFAGACIAIVTAVVVLCVLLSRKHSSGAVHPSATSAVFTASQSAPATTINFPQSNSPTATPPTQSTLPTATPHSTKPSSSSPYPTLPPELRYLHDGAACTADSQCRPPNHCQTASDTNSVNNEVYTTTTCCAPTQWGCPGWECKDYNDCLDPWKCAGTGSKKTCCGTGAPYTGTGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C3B8</accession>
    <name>A0A177C3B8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CC84DRAFT_1220264</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441556">
        <property type="protein sequence ID" value="OAG01886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032251.1">
        <property type="nucleotide sequence ID" value="XM_018183151.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C3B8"/>
    <dbReference type="GeneID" id="28766637"/>
    <dbReference type="InParanoid" id="A0A177C3B8"/>
    <dbReference type="OrthoDB" id="6499973at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF305">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="53"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="90"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="126"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="148"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="181"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="214"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="254"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="289"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="321"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="346"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="384"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="424"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="4">
        <location>
            <begin position="255"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAG01886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="454" mass="47112" checksum="6E3C8161CE2E17EA" modified="2016-09-07" version="1">MSSTTTEERIELTELATTDRASLTAYGTDAAQNPDEVPEDAAYSTTAIPDGGYGWMVVFCCSITAFWSNGVINCWGVLQAALLDSSLRSVPTSTVSFVGSLGLCLSAGLGIFVVQFMRWAGSRRTSMAGVCLMSASLISSSFCTAEVGALFGTMGILAGVGMSMVYTVSNGLPVQYFSGHLGLANGIVKLGGGIGGCVLAVAIEAMYRRVGIAWTFRIQGLVTLATGLPAAYMQKDRVRLRSVPLVDTSMFRSVPFVTVFFAGAIGSFALFVPPYFLPLFAQSINLSSSTGAGLVAAFNACNAVGRFAAGPLCDKIGPVNMFLITMILNAVSMLAIWPVSDTLAPLAVFAALNGAANGSFFTTLPTVVASMFGPGRAAVAMSMAVAGWSGGYLMGSPIAGYLLQAAGGKQQGGQGLGVEVYRPAIFYAGGVATASSLFVLFARFKMAKKVVEKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C3G2</accession>
    <name>A0A177C3G2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1251898</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441556">
        <property type="protein sequence ID" value="OAG01936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032301.1">
        <property type="nucleotide sequence ID" value="XM_018184347.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C3G2"/>
    <dbReference type="GeneID" id="28767833"/>
    <dbReference type="InParanoid" id="A0A177C3G2"/>
    <dbReference type="OrthoDB" id="5199481at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008057659" evidence="1">
        <location>
            <begin position="17"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG01936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="191" mass="20412" checksum="580297B002C00F08" modified="2016-09-07" version="1">MKTLIVAVALSSLAFATPLAPWEASAPPPAGTTFYQLQAKTSSAPSANNQYVQYPSNPSQYRYQLSKPGGENAGTPAKFFLRKYEATGTYAIHNSDDTRQIALAGDDSVLLYLTDATNPSAGNIPGGQLMEWATFTTEGNVLGVKDGSALTNRTFVAVRGTSDSWFVALYDGVSSSREMIYPITLNLVKVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C3H4</accession>
    <name>A0A177C3H4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CENP-V/GFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CC84DRAFT_1198415</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfa family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441556">
        <property type="protein sequence ID" value="OAG02173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032538.1">
        <property type="nucleotide sequence ID" value="XM_018181563.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C3H4"/>
    <dbReference type="STRING" id="1460663.A0A177C3H4"/>
    <dbReference type="GeneID" id="28765049"/>
    <dbReference type="InParanoid" id="A0A177C3H4"/>
    <dbReference type="OrthoDB" id="9985472at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016846">
        <property type="term" value="F:carbon-sulfur lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1590.10">
        <property type="entry name" value="glutathione-dependent formaldehyde- activating enzyme (gfa)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006913">
        <property type="entry name" value="CENP-V/GFA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337:SF43">
        <property type="entry name" value="CENP-V_GFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337">
        <property type="entry name" value="GFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04828">
        <property type="entry name" value="GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51891">
        <property type="entry name" value="CENP_V_GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CENP-V/GFA" evidence="5">
        <location>
            <begin position="26"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAG02173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="170" mass="19206" checksum="8199F07380B4E000" modified="2016-09-07" version="1">MSNITYKSDFTGDPKQHDVSKFSESMTGTCLCGSISVTIHDNELFGDKPRGHLCHCVNCRKVAGSFVSSNMAIEKEKVTYEDKNGTLKVYDDWETGSGKKVKRCFCGNCGSPIMSQPDIFPHMYMLKMGMFPRIPKPECESFAEHRHDWQGKHEGLEQYALIRGQKKLGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C3P2</accession>
    <name>A0A177C3P2_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phytanoyl-CoA hydroxylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1262797</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441557">
        <property type="protein sequence ID" value="OAG01781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032146.1">
        <property type="nucleotide sequence ID" value="XM_018185179.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C3P2"/>
    <dbReference type="STRING" id="1460663.A0A177C3P2"/>
    <dbReference type="GeneID" id="28768665"/>
    <dbReference type="InParanoid" id="A0A177C3P2"/>
    <dbReference type="OrthoDB" id="2328924at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40128">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40128:SF1">
        <property type="entry name" value="PHYTANOYL-COA HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG01781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="334" mass="37153" checksum="C8C48443544137D5" modified="2016-09-07" version="1">MPHAESPEPEIPSFDGKKLYVNDGLLHPEQVGPLRQSSPDLPVEELRKRYEEDGYVFLKGLLPREDVLKAREEYFNRLAPSGVLKPGTAPVEGIFDDGKDAADYPGIGAGASPGNGRPGAGTAEVFVDLALQAHYDEWYKERFCKHPVLRDAIARISGWGEDTLPVRRSLLRNNTPGNKAIGVHYDQIFLRHGEPTSFTAWVPMGDISLTGGGLIYLENGNSLGREIEADFARKAKESGLSDEEAKNAFNQNMLSTGLLADGPKEYSETFRKRWLVTSYEAGDVVLHTPYTIHASTINFDPCNVIRVGTDLRFVNGSRPWDKRWDKDYEFNDGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C4N2</accession>
    <name>A0A177C4N2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CC84DRAFT_1127585</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV441557">
        <property type="protein sequence ID" value="OAG01687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032052.1">
        <property type="nucleotide sequence ID" value="XM_018175779.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C4N2"/>
    <dbReference type="GeneID" id="28759265"/>
    <dbReference type="InParanoid" id="A0A177C4N2"/>
    <dbReference type="OrthoDB" id="10021397at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046943">
        <property type="term" value="F:carboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000196">
        <property type="entry name" value="MFS toxin efflux pump (AflT)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000436">
        <property type="entry name" value="MFS transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1720.10:FF:000013">
        <property type="entry name" value="Related to multidrug resistance proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF78">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01036">
        <property type="entry name" value="TCRTETB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="24"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="62"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="117"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="150"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="220"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="249"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="280"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="322"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="355"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="379"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="425"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="488"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="27"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="514"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="514"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAG01687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="558" mass="60135" checksum="CE27A81862885A35" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2023-06-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C553</accession>
    <name>A0A177C553_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1167174</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441556">
        <property type="protein sequence ID" value="OAG02022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032387.1">
        <property type="nucleotide sequence ID" value="XM_018179131.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C553"/>
    <dbReference type="GeneID" id="28762617"/>
    <dbReference type="InParanoid" id="A0A177C553"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG02022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="84" mass="9623" checksum="C7CAE04EF2F301D1" modified="2016-09-07" version="1">MRSDQRVSPIVRSAALAKDIRCLFSGSWHPEASVRLARRLRKTSTCALQSARPFSALCGWVFDVVFVQARWSYNRFCIGDMTRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C5D3</accession>
    <name>A0A177C5D3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Sterigmatocystin biosynthesis P450 monooxygenase stcL</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_1189421</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441556">
        <property type="protein sequence ID" value="OAG02099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032464.1">
        <property type="nucleotide sequence ID" value="XM_018181052.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C5D3"/>
    <dbReference type="STRING" id="1460663.A0A177C5D3"/>
    <dbReference type="GeneID" id="28764538"/>
    <dbReference type="InParanoid" id="A0A177C5D3"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11058">
        <property type="entry name" value="CYP60B-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF210">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE ASQL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 7" id="KW-0349">Heme</keyword>
    <keyword evidence="5 6 7" id="KW-0408">Iron</keyword>
    <keyword evidence="4 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="6">
        <location>
            <position position="439"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAG02099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="493" mass="55289" checksum="91E98347B1D75EB1" modified="2016-09-07" version="1">MGSTGMLVAATVLLAIVHRAYLAVYRLYLSPLSTIPGPKLWAISSIPYHVTTIRGNMHLRLVDFTKQYGPTIRVSPNHIAFTSPQAFKDIYAGTTKTAFPINPIYYNAPINGVHSLLTAPGDDHARQRRHLAAGFSKESLHAQEPVIRRYVDDLMHRLSSEAQTGPVAISDWFNSFTFDLTSELLFSESFECLSSGRLHPWIALLFGSIKGMVYISAVKCFPALDWALMKMMPQHLIDMQRDHFNLSAAKVDRRIELGSGRADLLSPVLRNGVGETHGLPVREKRLKTKADGRSFIVAGSETTGTALAGITYHLCKNSTTLSTLLSEIRSSFPSADDITIDSATKLPYLDAVIREGLRIYPPFAAGNHRVAPKGGDYVDGHFVPEGTHLYGYHYALYHSPAYFALPSEFCPERWLGTDARFSKDQLDGVRPFGLGPRMCIGQNLAWAELRLVLCNMLYRFDVKLRPECEGWIEQDLFYVWQKSRLMVELHRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C5Z6</accession>
    <name>A0A177C5Z6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1220643</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441556">
        <property type="protein sequence ID" value="OAG02302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032667.1">
        <property type="nucleotide sequence ID" value="XM_018183184.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C5Z6"/>
    <dbReference type="GeneID" id="28766670"/>
    <dbReference type="InParanoid" id="A0A177C5Z6"/>
    <dbReference type="OrthoDB" id="5411533at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG02302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="134" mass="15166" checksum="51AE601FA7FDF801" modified="2016-09-07" version="1">MSGLHLALQQGHIPAVLRHIQARQRPAVRARPTLSPTNTHSRTLQERDSPTLAHTTTSRAGRAITSSARIGWRLWPCPWPQRSRDQRCFDIGDIDTACINFKQVDRNKLMMNLARNGVDILTKKDDHSLAGLLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C6G0</accession>
    <name>A0A177C6G0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF1593-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1152618</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441556">
        <property type="protein sequence ID" value="OAG02280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032645.1">
        <property type="nucleotide sequence ID" value="XM_018176810.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C6G0"/>
    <dbReference type="STRING" id="1460663.A0A177C6G0"/>
    <dbReference type="GeneID" id="28760296"/>
    <dbReference type="InParanoid" id="A0A177C6G0"/>
    <dbReference type="OrthoDB" id="3592035at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016799">
        <property type="term" value="F:hydrolase activity, hydrolyzing N-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.245.10">
        <property type="entry name" value="Ribonucleoside hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036452">
        <property type="entry name" value="Ribo_hydro-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048527">
        <property type="entry name" value="Sde182_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011483">
        <property type="entry name" value="Sde182_NH-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21027">
        <property type="entry name" value="Sde0182_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07632">
        <property type="entry name" value="Sde182_NH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cellulose-binding Sde182 nucleoside hydrolase-like" evidence="1">
        <location>
            <begin position="14"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="Cellulose-binding Sde182 C-terminal" evidence="2">
        <location>
            <begin position="373"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG02280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="498" mass="55248" checksum="FA724B5DF02F2C47" modified="2016-09-07" version="1">MATARLQSFAQKPRVFILSDISNEPDDAESLCRYLLYANQFQTEGLVACTSTWMKNKVCPQDMHKIIDAYEGAVDTLNKHAHPDAQYPSAASLRGLIKKGPETYGMSAVGTDVPLSQGGELLLERILAPSLQPLWILCWGGTNVLASVLLKIDEKYTPEDSARLLSRLRVYAISDQDDTGAWIRNNFSDIFYIASVHGWNQYGMAAWTGISGDKYYGFDQGGPDFSKMEKSWIKENIQVGPLGSAYPDYMFIPEGDTPTFLYLIQNGLGSSEFPEYGSWGGRYARTDISADGLNSNHYSDAVDRVKGLDGRIHTSNHAAIWRWRDAFQDDFAARIKWTLEPDFAKVNHHPVVAVNGKFGLEPLRLEAEAGESITLDASASYDPDANDKLTFKWWHYREPTATQWWVEAEVSELVIKPLDANSSKIEVVLPPAEKCAVELMSRQPMAKGQQLHLILEVTDNGTPALTTYRRVVIQATNKDLKGGGKGADAIGDIMAAHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C6M1</accession>
    <name>A0A177C6M1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">WSC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1260567</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG03404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033769.1">
        <property type="nucleotide sequence ID" value="XM_018184995.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C6M1"/>
    <dbReference type="STRING" id="1460663.A0A177C6M1"/>
    <dbReference type="GeneID" id="28768481"/>
    <dbReference type="InParanoid" id="A0A177C6M1"/>
    <dbReference type="OrthoDB" id="2019572at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051589">
        <property type="entry name" value="Sialate-O-sulfotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002889">
        <property type="entry name" value="WSC_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45964">
        <property type="entry name" value="WSCD FAMILY MEMBER CG9164"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45964:SF5">
        <property type="entry name" value="WSCD FAMILY MEMBER CG9164"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01822">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51212">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="WSC" evidence="2">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG03404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="159" mass="17044" checksum="0790C3CFD24674F5" modified="2016-09-07" version="1">MTAALCSNYCSQFAYFGLENSSECWCGPFLKNSTQTPLSECSFLCSGDHTASCGAFGHISVYHSSDPSKVSNDPAVPASPIDNYTYANCQVDSTMPRLLSNGGAAANMSVEGCLLLAEAMQYTYAGLEYSNECWLGNALANNGEPEGARERLQSQLCWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C6P1</accession>
    <name>A0A177C6P1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Longevity assurance proteins LAG1/LAC1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CC84DRAFT_1020023</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sphingosine N-acyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441556">
        <property type="protein sequence ID" value="OAG02407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032772.1">
        <property type="nucleotide sequence ID" value="XM_018173375.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C6P1"/>
    <dbReference type="STRING" id="1460663.A0A177C6P1"/>
    <dbReference type="GeneID" id="28756861"/>
    <dbReference type="InParanoid" id="A0A177C6P1"/>
    <dbReference type="OrthoDB" id="537032at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050291">
        <property type="term" value="F:sphingosine N-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016439">
        <property type="entry name" value="Lag1/Lac1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006634">
        <property type="entry name" value="TLC-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12560:SF0">
        <property type="entry name" value="LD18904P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12560">
        <property type="entry name" value="LONGEVITY ASSURANCE FACTOR 1 LAG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03798">
        <property type="entry name" value="TRAM_LAG1_CLN8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00724">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50922">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="61"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="108"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="152"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="196"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="279"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="361"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="TLC" evidence="9">
        <location>
            <begin position="146"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="445"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="469"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAG02407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="485" mass="54984" checksum="0FA14343876C4C32" modified="2016-09-07" version="1">MISCRSSDTGGLGKAAGIAPSNNERLNGANGTHKPYKRAKPRTENDGLFTYLCMQLCEHQVGIAVNLLSLLFLTHIFFPRARQHTRKFYHLSYYNAENGKYGCGTDDLAYVALWLVLFVGLRVAVMDYVLAPLARCGGIRTKKGLVRFQEQAWLVCYCVCSWSLGMYILWNSEYFFNLHGMWKGWPFREICGLSKFYYLAQWAFWIAQILVVNIEEKRKDYAEMFTHHIFTIALLFLSYGYYHTRVGIVILCIMDLVDIVLPTAKLLKYMGYANICDIFFGLFVVVWLVTRQAFFPMVIYSVYKHSPIDMEPGCYFADGTMVAANETERYDALGGNVVWPNLVKAYTDREGPVCWNPTIRFSFLTLLLCLQAIIFLWFCMIVRVVVNVIRGNSADDVRSDDEGDDEEMEDVKTGYEAHHVAAAPLEQEVGVESLNFASRKSMNANGAAAVRRSKNQRSTRSSGISIPGHGDHKELLGRIGCDKPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C729</accession>
    <name>A0A177C729_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Beta-galactosidase</fullName>
            <ecNumber evidence="5">3.2.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CC84DRAFT_1251639</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.</text>
            <dbReference type="EC" id="3.2.1.23"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the glycosyl hydrolase 35 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.23" evidence="5"/>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG03345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033710.1">
        <property type="nucleotide sequence ID" value="XM_018184334.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C729"/>
    <dbReference type="STRING" id="1460663.A0A177C729"/>
    <dbReference type="GeneID" id="28767820"/>
    <dbReference type="InParanoid" id="A0A177C729"/>
    <dbReference type="OrthoDB" id="1657402at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004565">
        <property type="term" value="F:beta-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000251">
        <property type="entry name" value="Beta-galactosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026283">
        <property type="entry name" value="B-gal_1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048912">
        <property type="entry name" value="BetaGal1-like_ABD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048913">
        <property type="entry name" value="BetaGal_gal-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031330">
        <property type="entry name" value="Gly_Hdrlase_35_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019801">
        <property type="entry name" value="Glyco_hydro_35_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001944">
        <property type="entry name" value="Glycoside_Hdrlase_35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23421">
        <property type="entry name" value="BETA-GALACTOSIDASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21317">
        <property type="entry name" value="BetaGal_ABD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21467">
        <property type="entry name" value="BetaGal_gal-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01301">
        <property type="entry name" value="Glyco_hydro_35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006336">
        <property type="entry name" value="B-gal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00742">
        <property type="entry name" value="GLHYDRLASE35"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01182">
        <property type="entry name" value="GLYCOSYL_HYDROL_F35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008057894" description="Beta-galactosidase" evidence="7">
        <location>
            <begin position="20"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase 35 catalytic" evidence="8">
        <location>
            <begin position="25"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-galactosidase 1-like first all-beta" evidence="9">
        <location>
            <begin position="390"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-galactosidase galactose-binding" evidence="10">
        <location>
            <begin position="524"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="172"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR006336-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF21317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF21467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OAG03345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="622" mass="67693" checksum="C081615F67D3AF5C" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2023-06-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C734</accession>
    <name>A0A177C734_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_840709</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG03453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033818.1">
        <property type="nucleotide sequence ID" value="XM_018187616.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C734"/>
    <dbReference type="GeneID" id="28771102"/>
    <dbReference type="InParanoid" id="A0A177C734"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG03453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="70" mass="7910" checksum="066D53E836C17968" modified="2016-09-07" version="1">METSSRCLETSATTIIPTTIGNNANIHRHHYHYLVSSSDGPMVPKRPKATTMRMRDTRPSNQCIGSFELY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C7L0</accession>
    <name>A0A177C7L0_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Alb1-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_1261440</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG02737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033102.1">
        <property type="nucleotide sequence ID" value="XM_018185066.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C7L0"/>
    <dbReference type="FunCoup" id="A0A177C7L0">
        <property type="interactions" value="127"/>
    </dbReference>
    <dbReference type="GeneID" id="28768552"/>
    <dbReference type="InParanoid" id="A0A177C7L0"/>
    <dbReference type="OrthoDB" id="5304887at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053278">
        <property type="entry name" value="Pre-60S_factor_ECM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022784">
        <property type="entry name" value="Ribosome_bgen_Alb1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28280">
        <property type="entry name" value="SHUTTLING PRE-60S FACTOR ECM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28280:SF1">
        <property type="entry name" value="SHUTTLING PRE-60S FACTOR ECM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09135">
        <property type="entry name" value="Alb1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="133"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="190"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="34"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="68"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="82"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAG02737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="210" mass="22213" checksum="D1070F198CF72250" modified="2016-09-07" version="1">MGKTAKPKARQISTHSRAARRAASPSLDAPTAAKPSNLSRTRSTSPDHKTTKPHILAASTGAGISKAKSPKAKPMKRGQRLRALEAAEKAEANAEKLALKVAKSLGREKKVKERRKGWEDINEAKRKKAAKANAFGALGGDDDDEVKGGGEWETLGDEVMDGADAEGVNEDSVVEGKVDVDVAAGLACTSREDPKLQAMPLPDDDVDPDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C7S5</accession>
    <name>A0A177C7S5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1178414</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG02828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033193.1">
        <property type="nucleotide sequence ID" value="XM_018180341.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C7S5"/>
    <dbReference type="GeneID" id="28763827"/>
    <dbReference type="InParanoid" id="A0A177C7S5"/>
    <dbReference type="OrthoDB" id="5230585at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG02828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="196" mass="23279" checksum="86E5E59DA965B9E2" modified="2016-09-07" version="1">MSPSKNPYELLAQLDLRGQEEEKEEDELVGRDPNGDEIWKFEVTPFNIDDFEVKYDNWRIITREFLQQIAKNKELTETAVENKERRTIMHCPSQGEPESGERFCVVDTAEIEYGRAAEVGVRYLVRVELHRDFQQFRQNSLSVKLLRYYNDDPDDDVDWIPVPYVLNLVKHNNGESYKSVEHMVEWRNQLQQIKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C870</accession>
    <name>A0A177C870_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 20">Serine/threonine-protein kinase Tel1</fullName>
            <ecNumber evidence="5 20">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">CC84DRAFT_1125200</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25 26">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17 20">Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Required for the control of telomere length and genome stability.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Associates with DNA double-strand breaks.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 20">Chromosome</location>
            <location evidence="2 20">Telomere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 20">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 20">Belongs to the PI3/PI4-kinase family. ATM subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="5 20"/>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG03052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033417.1">
        <property type="nucleotide sequence ID" value="XM_018175714.1"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177C870"/>
    <dbReference type="GeneID" id="28759200"/>
    <dbReference type="InParanoid" id="A0A177C870"/>
    <dbReference type="OrthoDB" id="381190at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05171">
        <property type="entry name" value="PIKKc_ATM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1010.10:FF:000019">
        <property type="entry name" value="Serine/threonine-protein kinase Tel1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1010.10">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038980">
        <property type="entry name" value="ATM_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003152">
        <property type="entry name" value="FATC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057564">
        <property type="entry name" value="HEAT_ATR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014009">
        <property type="entry name" value="PIK_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044107">
        <property type="entry name" value="PIKKc_ATM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021668">
        <property type="entry name" value="TAN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37079">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE ATM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37079:SF4">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE ATM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02260">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23593">
        <property type="entry name" value="HEAT_ATR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11640">
        <property type="entry name" value="TAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01343">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01342">
        <property type="entry name" value="TAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51189">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51190">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00916">
        <property type="entry name" value="PI3_4_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 20" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14 20" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="7 20" id="KW-0158">Chromosome</keyword>
    <keyword evidence="11 20" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12 20" id="KW-0418">Kinase</keyword>
    <keyword evidence="10 20" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16 20" id="KW-0539">Nucleus</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 20" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="15 20" id="KW-0779">Telomere</keyword>
    <keyword evidence="9 20" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FAT" evidence="23">
        <location>
            <begin position="1896"/>
            <end position="2502"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="22">
        <location>
            <begin position="2615"/>
            <end position="2926"/>
        </location>
    </feature>
    <feature type="domain" description="FATC" evidence="24">
        <location>
            <begin position="2956"/>
            <end position="2988"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="180"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="2894"/>
            <end position="2944"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="2899"/>
            <end position="2911"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00014619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00025079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU365027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS51189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS51190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="OAG03052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="2988" mass="334752" checksum="2F2E893C687F31DE" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C9A5</accession>
    <name>A0A177C9A5_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Polyketide cyclase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1167042</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG03337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033702.1">
        <property type="nucleotide sequence ID" value="XM_018179108.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C9A5"/>
    <dbReference type="GeneID" id="28762594"/>
    <dbReference type="InParanoid" id="A0A177C9A5"/>
    <dbReference type="OrthoDB" id="5289017at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019587">
        <property type="entry name" value="Polyketide_cyclase/dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10604">
        <property type="entry name" value="Polyketide_cyc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG03337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="153" mass="17023" checksum="84306509F4681999" modified="2016-09-07" version="1">MSLLAVESHNNITRSTSNVFAFVSSPSNWAGLHPGSKKIIGEGVTGSAAVGTRFVEVIDDDNGNVFDASWMIIRSINDELFQFQFPSDFARGPFQEIVITYNVTPEADGSMAFTRRMASWIRPGIDAEKLISFSKNDMHNQYMANVKAKVERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C9C7</accession>
    <name>A0A177C9C7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CC84DRAFT_1189230</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG03330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033695.1">
        <property type="nucleotide sequence ID" value="XM_018181037.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C9C7"/>
    <dbReference type="FunCoup" id="A0A177C9C7">
        <property type="interactions" value="69"/>
    </dbReference>
    <dbReference type="GeneID" id="28764523"/>
    <dbReference type="InParanoid" id="A0A177C9C7"/>
    <dbReference type="OrthoDB" id="10021397at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000196">
        <property type="entry name" value="MFS toxin efflux pump (AflT)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1720.10:FF:000012">
        <property type="entry name" value="MFS toxin efflux pump (AflT)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF199">
        <property type="entry name" value="MFS EFFLUX TRANSPORTER INPD-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="91"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="198"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="228"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="265"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="306"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="331"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="362"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="393"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="467"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="2"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAG03330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="529" mass="57460" checksum="DE194D3540CBDE62" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CAK7</accession>
    <name>A0A177CAK7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1166275</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG04171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034536.1">
        <property type="nucleotide sequence ID" value="XM_018178917.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CAK7"/>
    <dbReference type="GeneID" id="28762403"/>
    <dbReference type="InParanoid" id="A0A177CAK7"/>
    <dbReference type="OrthoDB" id="4132046at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008057900" evidence="1">
        <location>
            <begin position="20"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG04171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="256" mass="27317" checksum="5918AA3DC768D72B" modified="2016-09-07" version="1">MRTSTALFALAATTSTVIARPGAWQYTTDLEIIVSLSNSDKALGSRTGFLQGQRQEQPPDNSKGPFKTVNIIVGKNVENKDIRCKLIAPGGQPIKARRGENNVDQTFADAGKGEWAFLEDSEVESIICDPAFKKGDGSGNGGDAAGKIVRVVLSDQATETGVAFELASDKRDEEAIKPSTVFSAIEIQAPADVKATLRCQIEDKSGNIIVATRGPNTDKTFSDAGKGAWDFKIPKRAQVSKIICDPAFKADPITSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CBE5</accession>
    <name>A0A177CBE5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_817148</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG05013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035378.1">
        <property type="nucleotide sequence ID" value="XM_018187526.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CBE5"/>
    <dbReference type="GeneID" id="28771012"/>
    <dbReference type="InParanoid" id="A0A177CBE5"/>
    <dbReference type="OrthoDB" id="10611146at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="251"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="335"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="277"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG05013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="359" mass="39298" checksum="A11B68D271B35FE5" modified="2016-09-07" version="1">MQQGYQGLVAQATTAAHCSTHTDDPTTPCCRPATTCPCRPPCDGCSAHAGVEAASPLQHARCIAALELQLMALFSVYMYPRCSLARGRRRRSFHPRHAGSFSWEVAATAMAHDAFHSSQTCALADRRVVCAAVPRKAAARACSRPVETRQPATLQHQHAFERLQNPSQTQRGATHFVLVQNNHDDLVPARPSVYISPIGALRRLAHKTPLRLAPGREHPPASPERLSPSALGAASVSLMRRFCCSATNVCQPPEGRQEHQPAGRRCPPPPDRRSGRLHSTTRTPTATHRRGQRPCGRIAQLPADQAQRTLLARATEAMPRLVCTAFGARLYKGHAGVARSSRERRRRPACHAALRQSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CBU9</accession>
    <name>A0A177CBU9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cora-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1260121</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG04806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035171.1">
        <property type="nucleotide sequence ID" value="XM_018184969.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CBU9"/>
    <dbReference type="STRING" id="1460663.A0A177CBU9"/>
    <dbReference type="GeneID" id="28768455"/>
    <dbReference type="InParanoid" id="A0A177CBU9"/>
    <dbReference type="OrthoDB" id="5428055at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="504"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG04806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="549" mass="62219" checksum="8A2EA00446030EEA" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CC66</accession>
    <name>A0A177CC66_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CC84DRAFT_1147916</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG04916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035281.1">
        <property type="nucleotide sequence ID" value="XM_018176610.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CC66"/>
    <dbReference type="GeneID" id="28760096"/>
    <dbReference type="InParanoid" id="A0A177CC66"/>
    <dbReference type="OrthoDB" id="5329176at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF158">
        <property type="entry name" value="MEMBRANE PROTEIN PTH11-LIKE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="91"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="127"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="177"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="212"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="27"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="338"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="354"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="373"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAG04916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="457" mass="52205" checksum="0ABF9F0B4FD90F65" modified="2016-09-07" version="1">MPRYPLQDTCLAVITFTPVLASIFVALRIYTRRKLNLRLGWDDWLIVFPTILSLALIGPSWRHVKMWHVGIHIFDVPPNDIEPNYDEYHQILLAFNLLNIPILPLVKVSIILLLLRAGSVIEWMKKTLYGILIFTVGSALIPWCLYIFICPPQTGNTWKPRTFGGLHCMGRHRMGEMLIWVTCANLLTDLLIFPIPFIIVRRMMSARLRSRLVVLAVFTSSLAVTAIGAAKIYLTYRDRLFTSFKTDWTYPIDYCISHIENNVAIIVANIPILRGLVTRWVFNFKTKATPIEREFRSEWQWSNSNSSSITHVASRKRRFLNKILPCLTDDFSSSLARSGDIMDSGKQRGLKPAVLRKKSRSSKPRSHKPSRRNSVDRYETADSLEKGDALETVTSIESLGSGPTLVDNHKEIEWRLSEATMASSPRRPSEATFSPIVPLSPVLLREVDDEDEILRYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CCI0</accession>
    <name>A0A177CCI0_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CC84DRAFT_1218700</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG05345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035710.1">
        <property type="nucleotide sequence ID" value="XM_018183026.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CCI0"/>
    <dbReference type="STRING" id="1460663.A0A177CCI0"/>
    <dbReference type="GeneID" id="28766512"/>
    <dbReference type="InParanoid" id="A0A177CCI0"/>
    <dbReference type="OrthoDB" id="3682774at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF167">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="16"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="93"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="128"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="188"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="213"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="251"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="36"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="290"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="316"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="290"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="344"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAG05345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="354" mass="38374" checksum="633EC41409D74F8C" modified="2016-09-07" version="1">MAPKNTDPARAAESNLGYLLGVTATFHVVALLFVSMRMYARISLVKAFGRDDALMLASTACVLLGGIVTYILAAQHGLGHHTDTLEKADYHEYLKMTFIQAIVSTIGGMSFLKLSIGCSLLRIGTPPLYTRVLWGLIAFVCLYTVISWGEWAAVCTPVAGFWTKDPKAKCLPTKTHKGFALMNTTCNIFTDICFATIPIPIILGLQMKRKTRIYLISILSLGYVAVVAGIVKTVMQNTKRGDPDQSFTNDIQFWGFIQVNLGIIAACAPALKPLVGGVLRLPSTHLSESRSNNYGPGINGQSKSVSRVRVSTHGLGHNHGWERADSDIELDNASFSSQAGITKPGDKKDDPRVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CCL9</accession>
    <name>A0A177CCL9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1216736</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG05383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035748.1">
        <property type="nucleotide sequence ID" value="XM_018182836.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CCL9"/>
    <dbReference type="STRING" id="1460663.A0A177CCL9"/>
    <dbReference type="GeneID" id="28766322"/>
    <dbReference type="InParanoid" id="A0A177CCL9"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF24">
        <property type="entry name" value="2-METHOXY-6-POLYPRENYL-1,4-BENZOQUINOL METHYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="26"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG05383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="429" mass="48925" checksum="FFF5E87CBB3ADAC8" modified="2016-09-07" version="1">MEEEPPPPENPATDRTGVPPKRPRTNSDSSTSLESLRSTRTLQSDDVEFVYENGREYGNDSYYMPCDQAENDRLAIHHRIYTHALKGKLTTTPVTSATRRILDLGTGPGHWAVAMARQHPHADVVGVDMAVWDIETTEESVGCTGVNWEIDDLDVWGVEDDFDDLTARLQRYDMSRDYANREPLAAAKTSRFKSALSTSDSSQPHTPSDSAYESYMLETEAQPGWHFSEPFDLIYMRGMKGVFAYWEGVYDEIYKNLNPGGWIEVVDFDMSLPNIEAGVDNFPFPTLARLYLGVMQAAFKSGRPVGTFYMHPTYLDDAGFTNIKQTYVNVPIGQWPEDEEQRTIGKMHLVCIMEMLESMLLRYLTMWGDANKDHWTKEEVQNMIEVGKGEIMDWASGTDRLGNIREGWCASYKWIIGRKPLHARDRRRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CCY9</accession>
    <name>A0A177CCY9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1176856</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG04669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035034.1">
        <property type="nucleotide sequence ID" value="XM_018180249.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CCY9"/>
    <dbReference type="GeneID" id="28763735"/>
    <dbReference type="InParanoid" id="A0A177CCY9"/>
    <dbReference type="OrthoDB" id="10574936at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="46"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="179"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="197"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="218"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG04669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="227" mass="22199" checksum="5B8BA2B7A91788F1" modified="2016-09-07" version="1">MAELHPIPSLLALSEAVRNTGTELESIGGKLHTLAAALEKEATVDPPSLTPSLTSPSSTPVQHADRQVDAQGLATERTSLQSQLAAAQAALAAAEQKAKSAAAPWGVDVCVGIRASSSDSSTVFRKMGCCTGCGDAVPPSPSVGRVSGGSAVGSLTPAGEARSQLSKALSEVAERAEKAASQVRSAAASGGAGGGSKAVSVVSRKSGGSGVGAGGGSRATSSHASQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CD64</accession>
    <name>A0A177CD64_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Saccharopine dehydrogenase [NADP(+), L-glutamate-forming]</fullName>
            <ecNumber evidence="8">1.5.1.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Saccharopine reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CC84DRAFT_1258998</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-saccharopine + NADP(+) + H2O = (S)-2-amino-6-oxohexanoate + L-glutamate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10020"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57951"/>
            <dbReference type="ChEBI" id="CHEBI:58321"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.5.1.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Amino-acid biosynthesis; L-lysine biosynthesis via AAA pathway; L-lysine from L-alpha-aminoadipate (fungal route): step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the saccharopine dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.10" evidence="8"/>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG05584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035949.1">
        <property type="nucleotide sequence ID" value="XM_018184870.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CD64"/>
    <dbReference type="FunCoup" id="A0A177CD64">
        <property type="interactions" value="160"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CD64"/>
    <dbReference type="GeneID" id="28768356"/>
    <dbReference type="InParanoid" id="A0A177CD64"/>
    <dbReference type="OrthoDB" id="10059875at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004755">
        <property type="term" value="F:saccharopine dehydrogenase (NADP+, L-glutamate-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.10:FF:000008">
        <property type="entry name" value="Alpha-aminoadipic semialdehyde synthase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000072">
        <property type="entry name" value="Saccharopine dehydrogenase [NADP(+), L-glutamate-forming]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1870.10:FF:000002">
        <property type="entry name" value="Saccharopine dehydrogenase Lys9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1870.10">
        <property type="entry name" value="Domain 3, Saccharopine reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051168">
        <property type="entry name" value="AASS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032095">
        <property type="entry name" value="Sacchrp_dh-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005097">
        <property type="entry name" value="Sacchrp_dh_NADP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11133:SF22">
        <property type="entry name" value="ALPHA-AMINOADIPIC SEMIALDEHYDE SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11133">
        <property type="entry name" value="SACCHAROPINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16653">
        <property type="entry name" value="Sacchrp_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03435">
        <property type="entry name" value="Sacchrp_dh_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Saccharopine dehydrogenase NADP binding" evidence="11">
        <location>
            <begin position="23"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="Saccharopine dehydrogenase-like C-terminal" evidence="12">
        <location>
            <begin position="141"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00051869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00060549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00066976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00067598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00083134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF16653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OAG05584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="467" mass="51180" checksum="346E14DFD78F5EC2" modified="2016-09-07" version="1">MEAITNKMQQVLGGGAPTSNHSVLLLGAGFVTRPTAEVLGNSGVKVTVACRTLAKAQALAKGISNASAISLDVSNDEALDAEVAKVDLVISLIPYTFHATVIKSAIRKKKNVVTTSYVSPAMEELDAQCKEAGITVFNEIGVDPGVDHLSAVITIDDVHKAGGKILSFKSYCGGLPAPEASGNPLGYKFSWSSRGVLLALRNQAKWWQDGKVKEVEGPELMAEAKPYFIYPGFAFVAYPNRDSTPYRERYLIPEAQTIVRGTLRYGGFPEYIKALVDIGFLVEDPKDFLKEGSTLSWREATSKIVGAKGATEEDIVWAISSRTKFPSTEEKDRILNGLRWLGLFSDEKITPRGNPLDTLCATLEKKMQYEEGERDMVMLQHRFEIENKDGSKDVRTETLVDYGDPKGYSSMAKLVGVPCAIAVQQVLDGTISKKGVLAPMDPEICRPLMKILEDKYNVRFKSETIRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CD71</accession>
    <name>A0A177CD71_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF410-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1216916</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GET4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG05585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035950.1">
        <property type="nucleotide sequence ID" value="XM_018182847.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CD71"/>
    <dbReference type="FunCoup" id="A0A177CD71">
        <property type="interactions" value="382"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CD71"/>
    <dbReference type="GeneID" id="28766333"/>
    <dbReference type="InParanoid" id="A0A177CD71"/>
    <dbReference type="OrthoDB" id="10252405at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072380">
        <property type="term" value="C:TRC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045048">
        <property type="term" value="P:protein insertion into ER membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000272">
        <property type="entry name" value="DUF410 domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007317">
        <property type="entry name" value="GET4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12875">
        <property type="entry name" value="GOLGI TO ER TRAFFIC PROTEIN 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12875:SF0">
        <property type="entry name" value="GOLGI TO ER TRAFFIC PROTEIN 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04190">
        <property type="entry name" value="GET4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG05585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="320" mass="35304" checksum="1C21D870B278C4DE" modified="2016-09-07" version="1">MSSKIDKTIQRQQEKIAEGQFYEAHQQLRVIAARYVKTSNWDAATDILFRGAQSLLQAGQGGSGGDLCIFLLEVFHKSETKPDAASKGKLLSLLRAFPKNEPTRKKFVNEMVGWSAKWGEYPAGDPEIHHVAGTLYAEDLEPYDAERHLIIGTKDSPEALAGLEYSWYTSDDSHTAPLYAARGTLPYLLAGNLRAANKYFLLFTSYLARNPSLATQEVSTKSSDLRVYPSLPLLNFLGLLLLAVERGDPSLFRQLKSHYASHLKDVNWTEALDTIGEMYFNIKIPRQGNPMFDMLGSMFGGGMGGGASKPAKKPPVAGLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CDQ3</accession>
    <name>A0A177CDQ3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CC84DRAFT_1205248</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG05446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035811.1">
        <property type="nucleotide sequence ID" value="XM_018181960.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CDQ3"/>
    <dbReference type="STRING" id="1460663.A0A177CDQ3"/>
    <dbReference type="GeneID" id="28765446"/>
    <dbReference type="InParanoid" id="A0A177CDQ3"/>
    <dbReference type="OrthoDB" id="9970124at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052202">
        <property type="entry name" value="Yeast_MetPath_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782:SF12">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="555"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="10">
        <location>
            <begin position="28"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OAG05446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="756" mass="84501" checksum="E60646E9EACFAD30" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CDS9</accession>
    <name>A0A177CDS9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10 11">Endo-1,4-beta-xylanase</fullName>
            <ecNumber evidence="4 10 11">3.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CC84DRAFT_1244313</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10 11">
            <text>Endohydrolysis of (1-&gt;4)-beta-D-xylosidic linkages in xylans.</text>
            <dbReference type="EC" id="3.2.1.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 10 11">Glycan degradation; xylan degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10 11">Belongs to the glycosyl hydrolase 11 (cellulase G) family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.8" evidence="4 10 11"/>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG05793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036158.1">
        <property type="nucleotide sequence ID" value="XM_018184148.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CDS9"/>
    <dbReference type="GeneID" id="28767634"/>
    <dbReference type="InParanoid" id="A0A177CDS9"/>
    <dbReference type="OrthoDB" id="2115822at2759"/>
    <dbReference type="UniPathway" id="UPA00114"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031176">
        <property type="term" value="F:endo-1,4-beta-xylanase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013319">
        <property type="entry name" value="GH11/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033123">
        <property type="entry name" value="GH11_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001137">
        <property type="entry name" value="Glyco_hydro_11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46828">
        <property type="entry name" value="ENDO-1,4-BETA-XYLANASE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46828:SF2">
        <property type="entry name" value="ENDO-1,4-BETA-XYLANASE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00457">
        <property type="entry name" value="Glyco_hydro_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00911">
        <property type="entry name" value="GLHYDRLASE11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51761">
        <property type="entry name" value="GH11_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10 11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8 10 11" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 10 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-0430">Lectin</keyword>
    <keyword evidence="9 10 11" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="5 10 11" id="KW-0858">Xylan degradation</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008058048" description="Endo-1,4-beta-xylanase" evidence="12">
        <location>
            <begin position="20"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="GH11" evidence="13">
        <location>
            <begin position="10"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="10">
        <location>
            <position position="98"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10">
        <location>
            <position position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OAG05793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="239" mass="26183" checksum="16C998C349FDBDA3" modified="2016-09-07" version="1">MFPFKLFIAAIALIPLAQGQQFQIQNWGNGEDATNYTYTSLAAGRFTLDWILGAGGNFVAGKGYRGNQNLVVNYTANYNPQGNSYLALYGFTSNPRVEFYVVEAFASHNPSDNAAQSFYGYHTSDGAQYELWSKYNGNLRQYWSVRRTNRRGGTITFNNHYKAWVAAGLPMGSLGNTFIVVEGQQGRGNADITVGVRPTTSIVETPTPITRSAVCVTPTQTIGTVCKPRGAKRTASFIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CEG0</accession>
    <name>A0A177CEG0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metallo-dependent hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1196227</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG06023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036388.1">
        <property type="nucleotide sequence ID" value="XM_018181443.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CEG0"/>
    <dbReference type="FunCoup" id="A0A177CEG0">
        <property type="interactions" value="49"/>
    </dbReference>
    <dbReference type="GeneID" id="28764929"/>
    <dbReference type="InParanoid" id="A0A177CEG0"/>
    <dbReference type="OrthoDB" id="413993at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053044">
        <property type="entry name" value="Metallo-hydrolase/TatD-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001130">
        <property type="entry name" value="TatD-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47345">
        <property type="entry name" value="CUT9-INTERACTING PROTEIN SCN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47345:SF1">
        <property type="entry name" value="CUT9-INTERACTING PROTEIN SCN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01026">
        <property type="entry name" value="TatD_DNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG06023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="321" mass="36018" checksum="0DEC11DFC399D63E" modified="2016-09-07" version="1">MSNSLEDDFPWHFGVFDAHCHPTDIMSSIDALPSMNARCLTVMGTRAQDQHLVAQVADKYGVKNPTPFSDFLAQTRRNLEKYPFALVGEIGLDRSFRIPEANPGDREDNELTPGGREGRRLTPFRCAPAHQKEIFKRQLQLAAELDRGVSLHGVQAHGLVFSTIKELWQEHQLPVLSKRERKKRETDGPSVTSHVSSQGADNDKPRPFPPRICLHSYSGSPDAFKQYLSPSIPVSFFASFSTAINLGNDLEGETPEAFVQMIETVPDDMLLVESDLHTAGAEMDERLEDMVRRICVIKGWGLDEGVRRLGDNWKRFVFGEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CFE3</accession>
    <name>A0A177CFE3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_722689</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG05430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035795.1">
        <property type="nucleotide sequence ID" value="XM_018187173.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CFE3"/>
    <dbReference type="GeneID" id="28770659"/>
    <dbReference type="InParanoid" id="A0A177CFE3"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG05430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="102" mass="11218" checksum="C00BE72070384113" modified="2016-09-07" version="1">MTDDICAADIAQRHAVQLISPCHCKRTATCVGSQACPVTGIHCSRMTAGGHRNPAERSIPLIANKHRIHGLHSRRRNIPNLPELSKHRSESAKASYRSCRSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CFG0</accession>
    <name>A0A177CFG0_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1090704</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG06344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036709.1">
        <property type="nucleotide sequence ID" value="XM_018174367.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CFG0"/>
    <dbReference type="STRING" id="1460663.A0A177CFG0"/>
    <dbReference type="GeneID" id="28757853"/>
    <dbReference type="InParanoid" id="A0A177CFG0"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF73">
        <property type="entry name" value="HET DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_8G01020)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="55"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG06344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="306" mass="35288" checksum="705331092003BC34" modified="2016-09-07" version="1" fragment="single">MESKCSESADGDETFWYQPLANPGSSIRLIEIDPDTASDGTVQLHLFESTFLEEYTCLSYVWGQEHDGGGPFRILVNGKTFNVRCNLNNFLCVARRKYAKRRLWIDAICIDQANTPERNHQVQQMGNIYSRAKEVIAWLGNNCLAAEIIPRIDSRARHTARHLPADIWFYLWLFMSTVRPDCWGLCGNPSGKRNKRSTALKEAVRGYWARAWVTQEIALAKRVRLLVHDTEFDLTALDSARMRNFRPTFRALGELYATNTRHYKSQDQHLVELLNNYAWKECAIERDRVFSLLSLCVEGADIKVDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CFJ4</accession>
    <name>A0A177CFJ4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Polyketide cyclase/dehydrase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1091732</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG05991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036356.1">
        <property type="nucleotide sequence ID" value="XM_018174410.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CFJ4"/>
    <dbReference type="GeneID" id="28757896"/>
    <dbReference type="InParanoid" id="A0A177CFJ4"/>
    <dbReference type="OrthoDB" id="2586183at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG05991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="190" mass="21641" checksum="187D765D2D154CA8" modified="2016-09-07" version="1">MATQSSILWPEHLLPGYTDNFVSNEVIAVNLTTQQIWELLADISRWNSYYKNCAQITEPDAGSYLKEGSVFKFSTFGFPPLTCTVMESVVPKQGTAGRLAWHSTTDDGLEVYHAWIVEELEKDRVRILTQEVQNGPVFKEWAREAPNKMLLGHQDWLDGLVQAARGQEVRRTNLESVNFPVRQLDSKKVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CFX6</accession>
    <name>A0A177CFX6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ubiquinone biosynthesis protein-like protein coq-8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CC84DRAFT_1196076</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. ADCK protein kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG05729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036094.1">
        <property type="nucleotide sequence ID" value="XM_018181437.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CFX6"/>
    <dbReference type="STRING" id="1460663.A0A177CFX6"/>
    <dbReference type="GeneID" id="28764923"/>
    <dbReference type="InParanoid" id="A0A177CFX6"/>
    <dbReference type="OrthoDB" id="201153at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13970">
        <property type="entry name" value="ABC1_ADCK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004147">
        <property type="entry name" value="ABC1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034646">
        <property type="entry name" value="ADCK3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051409">
        <property type="entry name" value="Atypical_kinase_ADCK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43851">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43851:SF3">
        <property type="entry name" value="COENZYME Q8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03109">
        <property type="entry name" value="ABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="ABC1 atypical kinase-like" evidence="6">
        <location>
            <begin position="551"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="72"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="139"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="373"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="88"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="156"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="177"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="216"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="266"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="373"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="393"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="436"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAG05729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="905" mass="100452" checksum="092F82DB67A214A4" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CGU7</accession>
    <name>A0A177CGU7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_765133</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG06451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036816.1">
        <property type="nucleotide sequence ID" value="XM_018187361.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CGU7"/>
    <dbReference type="GeneID" id="28770847"/>
    <dbReference type="InParanoid" id="A0A177CGU7"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG06451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="168" mass="19417" checksum="EAEAB4B53B33574E" modified="2016-09-07" version="1">MLTEAQAARFNAARNECLSKKDEDDARVEVWRQKSGHYDCRVPNGKHAAMLMRKTSSKFHHSFTTSLLQLSVSFYTMHFISWKKSTNMSLVNRIRGPKFIGHQSRSSPYRKTSSNCPILPNITTPRDKMNKSRHSTWKIRRSQSHMMPSPDHINWEDVAVAGSYEGLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CH09</accession>
    <name>A0A177CH09_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_745011</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG06070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036435.1">
        <property type="nucleotide sequence ID" value="XM_018187277.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CH09"/>
    <dbReference type="STRING" id="1460663.A0A177CH09"/>
    <dbReference type="GeneID" id="28770763"/>
    <dbReference type="InParanoid" id="A0A177CH09"/>
    <dbReference type="OrthoDB" id="40579at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47660">
        <property type="entry name" value="TRANSCRIPTION FACTOR WITH C2H2 AND ZN(2)-CYS(6) DNA BINDING DOMAIN (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00755">
        <property type="entry name" value="AFLATOXINBRP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="42"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="70"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="13"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="73"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAG06070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="366" mass="40418" checksum="E493D728ECEE96D9" modified="2016-09-07" version="1">MNQPTQVEAPKLSSPNPSAQTSPYQPKPHNPYQRMSQRRAIACTICAKAKTKCDKAVPSCSRCTAKGLQCEPRSTRRTSDNSYRKPTKHLVSPKRFPTANSIPTMGTMGTSPRSIPSSGRPQIMRTVSHMDFHTAAKLSQYPANFNNFNMLQPLPTSYTPQIIDEYSYSSSPEPNMGGFSRSMEQNSYITSSRAMTPSTPEPFAFNDPINIADPFDNYMNTPSWSDDGSMAVGLGFEHDMPGMLPNDMWSTPEPESITPMGLCDSPTVMNTWSHPALSVSPPQLPMGMPPHSKGVPSLSLSEASTEEFNSPSHMQQEWSNVQPHAGQIMGKPMVTSSFMDNVKSYAYPKAPQPIWEDIIVPRTQAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CH45</accession>
    <name>A0A177CH45_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_1217428</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG06169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036534.1">
        <property type="nucleotide sequence ID" value="XM_018182890.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CH45"/>
    <dbReference type="FunCoup" id="A0A177CH45">
        <property type="interactions" value="24"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CH45"/>
    <dbReference type="GeneID" id="28766376"/>
    <dbReference type="InParanoid" id="A0A177CH45"/>
    <dbReference type="OrthoDB" id="9975416at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051016">
        <property type="entry name" value="Diverse_Substrate_AcTransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10545:SF42">
        <property type="entry name" value="ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10545">
        <property type="entry name" value="DIAMINE N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="3">
        <location>
            <begin position="3"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAG06169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="150" mass="16924" checksum="75502700F55AD7EA" modified="2016-09-07" version="1">MPITVTSLSCQDYTQWSSLWAQYLSETANTTLPESQFHSTFARLVAPDGDIHGLVLRDSETGSLLGLAHFTGLASPWSEKRICYMSDLFVAVNERNKGYGRRLLNAVAEAGRLLNCRRVSWITGTDNVVARRLYDKLAASKDVYYRWDLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CI13</accession>
    <name>A0A177CI13_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CC84DRAFT_1186190</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG07145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037510.1">
        <property type="nucleotide sequence ID" value="XM_018180843.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CI13"/>
    <dbReference type="STRING" id="1460663.A0A177CI13"/>
    <dbReference type="GeneID" id="28764329"/>
    <dbReference type="InParanoid" id="A0A177CI13"/>
    <dbReference type="OrthoDB" id="5290825at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015798">
        <property type="term" value="P:myo-inositol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015791">
        <property type="term" value="P:polyol transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000474">
        <property type="entry name" value="Sugar transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050814">
        <property type="entry name" value="Myo-inositol_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020">
        <property type="entry name" value="PROTON MYO-INOSITOL COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020:SF4">
        <property type="entry name" value="SYMPORT, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G11790)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="126"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="159"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="184"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="217"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="251"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="338"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="371"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="403"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="430"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="469"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="501"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="86"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAG07145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="584" mass="64496" checksum="7B49385630B91E13" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CII9</accession>
    <name>A0A177CII9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SMP-30/Gluconolactonase/LRE-like region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CC84DRAFT_1163095</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="3">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the SMP-30/CGR1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG06792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037157.1">
        <property type="nucleotide sequence ID" value="XM_018178174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CII9"/>
    <dbReference type="FunCoup" id="A0A177CII9">
        <property type="interactions" value="40"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CII9"/>
    <dbReference type="GeneID" id="28761660"/>
    <dbReference type="InParanoid" id="A0A177CII9"/>
    <dbReference type="OrthoDB" id="423498at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004341">
        <property type="term" value="F:gluconolactonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013658">
        <property type="entry name" value="SGL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005511">
        <property type="entry name" value="SMP-30"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10907">
        <property type="entry name" value="REGUCALCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10907:SF47">
        <property type="entry name" value="REGUCALCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08450">
        <property type="entry name" value="SGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01790">
        <property type="entry name" value="SMP30FAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="SMP-30/Gluconolactonase/LRE-like region" evidence="4">
        <location>
            <begin position="20"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="2">
        <location>
            <position position="223"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="22"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR605511-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR605511-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAG06792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="329" mass="36349" checksum="D3865791CEBA3017" modified="2016-09-07" version="1">MSDVKKYEITEPWIKLHCALGEAPFWEESTNTIRFVDVEKQELHRVSVTEGPSSHKVVKQYDISIGCTADIEGNDTDFIFGGKYGYGICDKESGEYRWIKKVWSDEEVKAGKLNKFRGNDGAVDSGGRFWVGFMFDPLVTEMNNEGAVFRLHSDGTLDRPLDGITIPNGTTWNQTDDTMFFADSPFKTIYQFDYDAKTGHVSNKRPFFVMPEDNRYGEDAVPDGHCIDEEGYMWTALHGGSHVLRISPKGEIVAEIKVPTSQPTCPCFVGEELVITSAGGTAGEGGKPVDENAGSVFKINVGIRGLKRFRFKGGAAVEGGKEDGKVVSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CJB2</accession>
    <name>A0A177CJB2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1116870</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Cyclase 1 superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG06910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037275.1">
        <property type="nucleotide sequence ID" value="XM_018175470.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CJB2"/>
    <dbReference type="STRING" id="1460663.A0A177CJB2"/>
    <dbReference type="GeneID" id="28758956"/>
    <dbReference type="InParanoid" id="A0A177CJB2"/>
    <dbReference type="OrthoDB" id="5396at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004061">
        <property type="term" value="F:arylformamidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:L-tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.50">
        <property type="entry name" value="Putative cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007325">
        <property type="entry name" value="KFase/CYL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037175">
        <property type="entry name" value="KFase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34861">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34861:SF11">
        <property type="entry name" value="CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04199">
        <property type="entry name" value="Cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102198">
        <property type="entry name" value="Putative cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG06910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="319" mass="35939" checksum="AD14B5A5EEA9CE1C" modified="2016-09-07" version="1">MASSQMTRAYPKFSELPLDPQHPRYSAWGLWGKDDELGTLNHLTPERVVAAAKEVKTGARFGLNWALEQMDYTGGFRETIKHEIFQLGENMNDDRITFNTQTSTQWDGLRHWGFDDGRFYNGFTQKEIIENKSPRLGIQAWAKHGLVGRGVLIDFVSYAAKKNIEYDPLDFYAVPLKTAKQIAQDCSFDFQAGDIVLLRTGFTAAFEQASIETKKKIMAQSPFRYPGMESNFEVLGWLWDTQIAAVAGDCPGFEAWPPSEHALHQILLAGFGMPIGEMFALDELAQECERQKRWTFMLTSEPLNVRGGVASPPNALAIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CKD7</accession>
    <name>A0A177CKD7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 16">Protein transport protein SEC23</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">CC84DRAFT_1143968</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15 16">Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="16">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 16">Cytoplasmic vesicle</location>
            <location evidence="1 16">COPII-coated vesicle membrane</location>
            <topology evidence="1 16">Peripheral membrane protein</topology>
            <orientation evidence="1 16">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 16">Endoplasmic reticulum membrane</location>
            <topology evidence="2 16">Peripheral membrane protein</topology>
            <orientation evidence="2 16">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="16">Golgi apparatus membrane</location>
            <topology evidence="16">Peripheral membrane protein</topology>
            <orientation evidence="16">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 16">Belongs to the SEC23/SEC24 family. SEC23 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG07432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037797.1">
        <property type="nucleotide sequence ID" value="XM_018176441.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CKD7"/>
    <dbReference type="FunCoup" id="A0A177CKD7">
        <property type="interactions" value="1009"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CKD7"/>
    <dbReference type="GeneID" id="28759927"/>
    <dbReference type="InParanoid" id="A0A177CKD7"/>
    <dbReference type="OrthoDB" id="10256289at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030127">
        <property type="term" value="C:COPII vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070971">
        <property type="term" value="C:endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090110">
        <property type="term" value="P:COPII-coated vesicle cargo loading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01478">
        <property type="entry name" value="Sec23-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11287">
        <property type="entry name" value="Sec23_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.730:FF:000001">
        <property type="entry name" value="Protein transport protein SEC23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.380:FF:000001">
        <property type="entry name" value="Protein transport protein SEC23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.20.10:FF:000006">
        <property type="entry name" value="Protein transport protein SEC23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.410:FF:000008">
        <property type="entry name" value="Protein transport protein SEC23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1670">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.730">
        <property type="entry name" value="Sec23/Sec24 helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.380">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012990">
        <property type="entry name" value="Beta-sandwich_Sec23_24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007123">
        <property type="entry name" value="Gelsolin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036180">
        <property type="entry name" value="Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037364">
        <property type="entry name" value="Sec23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006900">
        <property type="entry name" value="Sec23/24_helical_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036175">
        <property type="entry name" value="Sec23/24_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006896">
        <property type="entry name" value="Sec23/24_trunk_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037550">
        <property type="entry name" value="Sec23_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006895">
        <property type="entry name" value="Znf_Sec23_Sec24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036174">
        <property type="entry name" value="Znf_Sec23_Sec24_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11141">
        <property type="entry name" value="PROTEIN TRANSPORT PROTEIN SEC23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11141:SF0">
        <property type="entry name" value="PROTEIN TRANSPORT PROTEIN SEC23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00626">
        <property type="entry name" value="Gelsolin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08033">
        <property type="entry name" value="Sec23_BS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04815">
        <property type="entry name" value="Sec23_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04811">
        <property type="entry name" value="Sec23_trunk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04810">
        <property type="entry name" value="zf-Sec23_Sec24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81995">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82754">
        <property type="entry name" value="C-terminal, gelsolin-like domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81811">
        <property type="entry name" value="Helical domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82919">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 16" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14 16" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="8 16" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10 16" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="12 16" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="13 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 16" id="KW-0653">Protein transport</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 16" id="KW-0813">Transport</keyword>
    <keyword evidence="9 16" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zinc finger Sec23/Sec24-type" evidence="18">
        <location>
            <begin position="60"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 trunk" evidence="19">
        <location>
            <begin position="127"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 beta-sandwich" evidence="21">
        <location>
            <begin position="406"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 helical" evidence="20">
        <location>
            <begin position="524"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="domain" description="Gelsolin-like" evidence="17">
        <location>
            <begin position="640"/>
            <end position="725"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00025471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU365030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF04810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF04811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF04815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF08033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="OAG07432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="772" mass="85779" checksum="24E279111EAB9B6A" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CKJ4</accession>
    <name>A0A177CKJ4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1161899</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG07826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038191.1">
        <property type="nucleotide sequence ID" value="XM_018177856.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CKJ4"/>
    <dbReference type="STRING" id="1460663.A0A177CKJ4"/>
    <dbReference type="GeneID" id="28761342"/>
    <dbReference type="InParanoid" id="A0A177CKJ4"/>
    <dbReference type="OrthoDB" id="2310150at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19075">
        <property type="entry name" value="AKR_AKR7A1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050523">
        <property type="entry name" value="AKR_Detox_Biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364:SF4">
        <property type="entry name" value="NAD(P)-LINKED OXIDOREDUCTASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364">
        <property type="entry name" value="NADH-SPECIFIC METHYLGLYOXAL REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="2">
        <location>
            <begin position="8"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG07826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="318" mass="35011" checksum="53B2AA1358F56593" modified="2016-09-07" version="1">MSANGIKIAFGGATWLFTPVDEVTEWLTFLKKSGIETIDTAQVYGSSEETMGKAGAASSFTIDTKAPGGLNEQPCTKDVIIDAGKKSLEKLKTNSVDVFYMHAPDRRLPVKETLSGLNELYKQGAFKRLGLSQYLGEEVEEIIRVAKENNFVVPSVYQGNYSAIARRAEAEIFPIIRKHNMAFYAYSPIAGGFLAKSKAALTESNGRFGEGQPLAQVYNGMYNRPSFVAALDVWEQIAKEENTTRAELAYRWIAYHSKLAGDQGDAIVVGARNMQQFEETMQALKGGPLSDAAVAKIDQVWESVKADAFLDNYEMLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2023-06-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CMH7</accession>
    <name>A0A177CMH7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_586019</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039100.1">
        <property type="nucleotide sequence ID" value="XM_018186782.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CMH7"/>
    <dbReference type="GeneID" id="28770268"/>
    <dbReference type="InParanoid" id="A0A177CMH7"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG08735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="77" mass="8331" checksum="B23D81467CBFEA89" modified="2016-09-07" version="1">MVKPVLFVSSYTTAYQSSAERGLHVFRGSRRSIGINLCEPLECDGAEVIIAIGTEKFVIHNKVAGTTFDASKALDRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CMK1</accession>
    <name>A0A177CMK1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">ATP-dependent 6-phosphofructokinase</fullName>
            <shortName evidence="16">ATP-PFK</shortName>
            <shortName evidence="16">Phosphofructokinase</shortName>
            <ecNumber evidence="16">2.7.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Phosphohexokinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">CC84DRAFT_1214642</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 16">Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15 16 17">
            <text>beta-D-fructose 6-phosphate + ATP = beta-D-fructose 1,6-bisphosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16109"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 16">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="16">Allosterically activated by ADP, AMP, or fructose 2,6-bisphosphate, and allosterically inhibited by ATP or citrate.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5 16 17">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 3/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="16">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 16">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Mitochondrion outer membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
            <orientation evidence="4">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="17">Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade "E" sub-subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.11" evidence="16"/>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038473.1">
        <property type="nucleotide sequence ID" value="XM_018182653.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CMK1"/>
    <dbReference type="FunCoup" id="A0A177CMK1">
        <property type="interactions" value="831"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CMK1"/>
    <dbReference type="GeneID" id="28766139"/>
    <dbReference type="InParanoid" id="A0A177CMK1"/>
    <dbReference type="OrthoDB" id="537915at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00182"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005945">
        <property type="term" value="C:6-phosphofructokinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003872">
        <property type="term" value="F:6-phosphofructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016208">
        <property type="term" value="F:AMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070095">
        <property type="term" value="F:fructose-6-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048029">
        <property type="term" value="F:monosaccharide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061621">
        <property type="term" value="P:canonical glycolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030388">
        <property type="term" value="P:fructose 1,6-bisphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006002">
        <property type="term" value="P:fructose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007035">
        <property type="term" value="P:vacuolar acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070072">
        <property type="term" value="P:vacuolar proton-transporting V-type ATPase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.450:FF:000010">
        <property type="entry name" value="ATP-dependent 6-phosphofructokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.460:FF:000007">
        <property type="entry name" value="ATP-dependent 6-phosphofructokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.460:FF:000008">
        <property type="entry name" value="ATP-dependent 6-phosphofructokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.450">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.460">
        <property type="entry name" value="Phosphofructokinase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03184">
        <property type="entry name" value="Phosphofructokinase_I_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009161">
        <property type="entry name" value="6-Pfructokinase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022953">
        <property type="entry name" value="ATP_PFK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015912">
        <property type="entry name" value="Phosphofructokinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000023">
        <property type="entry name" value="Phosphofructokinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035966">
        <property type="entry name" value="PKF_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02478">
        <property type="entry name" value="6PF1K_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13697:SF4">
        <property type="entry name" value="ATP-DEPENDENT 6-PHOSPHOFRUCTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13697">
        <property type="entry name" value="PHOSPHOFRUCTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00365">
        <property type="entry name" value="PFK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000533">
        <property type="entry name" value="ATP_PFK_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00476">
        <property type="entry name" value="PHFRCTKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53784">
        <property type="entry name" value="Phosphofructokinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00433">
        <property type="entry name" value="PHOSPHOFRUCTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 16" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="12 16 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 16" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14 16 17" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="11 16 17" id="KW-0418">Kinase</keyword>
    <keyword evidence="13 16" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 16 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 16 17" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphofructokinase" evidence="19">
        <location>
            <begin position="16"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphofructokinase" evidence="19">
        <location>
            <begin position="403"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal catalytic PFK domain 1" evidence="16">
        <location>
            <begin position="1"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Interdomain linker" evidence="16">
        <location>
            <begin position="389"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal regulatory PFK domain 2" evidence="16">
        <location>
            <begin position="403"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="18">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="16">
        <location>
            <position position="165"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="24"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="87"/>
            <end position="88"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="117"/>
            <end position="120"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="16">
        <location>
            <begin position="163"/>
            <end position="165"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="16">
        <location>
            <begin position="207"/>
            <end position="209"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="16">
        <location>
            <position position="263"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="290"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="16">
        <location>
            <begin position="296"/>
            <end position="299"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="16">
        <location>
            <position position="479"/>
        </location>
        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
            <note>allosteric activator; ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="16">
        <location>
            <begin position="536"/>
            <end position="540"/>
        </location>
        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
            <note>allosteric activator; ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="574"/>
        </location>
        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
            <note>allosteric activator; ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="16">
        <location>
            <begin position="581"/>
            <end position="583"/>
        </location>
        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
            <note>allosteric activator; ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="16">
        <location>
            <position position="641"/>
        </location>
        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
            <note>allosteric activator; ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="667"/>
        </location>
        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
            <note>allosteric activator; ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="16">
        <location>
            <begin position="673"/>
            <end position="676"/>
        </location>
        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
            <note>allosteric activator; ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="16">
        <location>
            <position position="745"/>
        </location>
        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
            <note>allosteric activator; ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRNR" id="PIRNR000533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="OAG08108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="773" mass="84754" checksum="16B1F0304DA706AD" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CMV2</accession>
    <name>A0A177CMV2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_536933</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038462.1">
        <property type="nucleotide sequence ID" value="XM_018186663.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CMV2"/>
    <dbReference type="GeneID" id="28770149"/>
    <dbReference type="InParanoid" id="A0A177CMV2"/>
    <dbReference type="OrthoDB" id="10562165at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG08097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="151" mass="16061" checksum="E19EBD4132BF1CC5" modified="2016-09-07" version="1">MKHRQEKSVLDNTKTPALSACRAIPALGQLAPLLPITYYTPAPASPAKQAFGMPTNPMAHHAVAHAVAYSAVLAHHHGCTTAEDDSSVYRPGGSRPHCEALALYARCLYPGAYDSGSVPGSWVGSSRTLCAALAAGSWEELVRRPMRGVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CMV4</accession>
    <name>A0A177CMV4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1214653</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038484.1">
        <property type="nucleotide sequence ID" value="XM_018182659.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CMV4"/>
    <dbReference type="GeneID" id="28766145"/>
    <dbReference type="InParanoid" id="A0A177CMV4"/>
    <dbReference type="OrthoDB" id="3945102at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="250"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="367"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="261"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="315"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="367"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="387"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG08119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="397" mass="44221" checksum="4B70D3B333D70AB2" modified="2016-09-07" version="1">MDDLNFLEQAAAADASATSTLMVLLPDGSVVQIHNISRFALLDKCPLLYHAFEFREFSEVEQASIEATSRSAVVSLLRFLYTGTYVSDPEECLGSLLPHAEAFKVAEDFDVPEFQVQAYVNFTRETEFACCNATPPSDLCETIRFIYEHFGGRNSNSDEHRSLLDTILNYCVSVFKYQLLGDRVDFRQTAFENFTFHQDLCRTSMRRNFEDDGANEIVQLPVCRPTPHSQATLLKRAIGDFQYEIFQDDEGPALEGNDTEGSSHTKKQEPSHGGFTLVHRPRTLGGGATCSASDSDSESSSDEFGFSLVHRPKPESQTEPVLTHSPTATDPFAKPFTDLVPSNPFHDPGPWEVIKPDVTVKLESAIKSEPTIKSDSNVKQETAGSTSDDEWDFVNWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CNX0</accession>
    <name>A0A177CNX0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">SUN-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CC84DRAFT_583850</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SUN family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038955.1">
        <property type="nucleotide sequence ID" value="XM_018186769.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CNX0"/>
    <dbReference type="FunCoup" id="A0A177CNX0">
        <property type="interactions" value="52"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CNX0"/>
    <dbReference type="GeneID" id="28770255"/>
    <dbReference type="InParanoid" id="A0A177CNX0"/>
    <dbReference type="OrthoDB" id="5339822at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051526">
        <property type="entry name" value="Beta-Glucosidase_SUN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005556">
        <property type="entry name" value="SUN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31316">
        <property type="entry name" value="BETA-GLUCOSIDASE-LIKE PROTEIN NCA3, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31316:SF0">
        <property type="entry name" value="SECRETED BETA-GLUCOSIDASE SIM1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03856">
        <property type="entry name" value="SUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-0134">Cell wall</keyword>
    <keyword evidence="9" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="79"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="79"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OAG08590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="443" mass="46851" checksum="EF423F1B45141A9D" modified="2016-09-07" version="1">MKYLSVALATAAATALAKPHGHAHAHRHAAVAKRAATAVYIPGPVETVVVYELNGHSISEEDVRNGIANGTLTWGEDGTLSSSAAVTPTSAPPAKSQPVDISNVAQDPEPVEQSEPELPASTSEPTEQPAEYNEAPDPSSYRPVGEDGSCSDCDKPFPNRKFKCSEFPAGYGAFHLGNEGLGGWSGIQAPAKRDVAGYHDIMTVPTGSCPDGGCCSPGRFCSYACPNPYLKMSFPKMQGAKKESVGGLFCNSDGMLEMADGSLSKTLCGRGSSRVRVMIQSKLSKPVSLCRTDYPGTESETLPLIVNPGETKELANPDQKSYYFWDNKPTSAQYYVNNQGVSEAQACTWGNGQGDTGNWAPVNIGTSFDDILSNMGYTGLMQNKPTNPGAKLNFVIRFTGDGVSNPCSYKNGQYYNSYGGGNPDGCTASVADGKTLTIVFSNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CNZ1</accession>
    <name>A0A177CNZ1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ecp2 effector protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1174319</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039286.1">
        <property type="nucleotide sequence ID" value="XM_018180090.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CNZ1"/>
    <dbReference type="GeneID" id="28763576"/>
    <dbReference type="InParanoid" id="A0A177CNZ1"/>
    <dbReference type="OrthoDB" id="3736915at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008058442" description="Ecp2 effector protein domain-containing protein" evidence="1">
        <location>
            <begin position="24"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG08921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="159" mass="17551" checksum="0041DC09CC47702E" modified="2016-09-07" version="1">MLFARTSLLALATSLSNISSAKAYWLVATDITSFIPGPVGGDGYQWIHVDNLECNTMIDAPLVNDRSDVSGDKQGVRMESEEGDCDHGGNWWATECPTEVEQHFPEFHQTWYADRDNTMVNLEGGVVGSCRVDMTHDIQCEVTAGMARFQTLLECTQTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CP09</accession>
    <name>A0A177CP09_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Amino acid permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CC84DRAFT_1194663</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038862.1">
        <property type="nucleotide sequence ID" value="XM_018181357.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CP09"/>
    <dbReference type="STRING" id="1460663.A0A177CP09"/>
    <dbReference type="GeneID" id="28764843"/>
    <dbReference type="InParanoid" id="A0A177CP09"/>
    <dbReference type="OrthoDB" id="3900342at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF1">
        <property type="entry name" value="GENERAL AMINO-ACID PERMEASE GAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="72"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="117"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="153"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="182"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="224"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="263"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="317"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="365"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="390"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="443"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="474"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="9">
        <location>
            <begin position="43"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAG08497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="541" mass="59406" checksum="CC704FA77578E786" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CP62</accession>
    <name>A0A177CP62_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">AttH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CC84DRAFT_1234719</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the Diels-Alderase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG09325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039690.1">
        <property type="nucleotide sequence ID" value="XM_018183827.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CP62"/>
    <dbReference type="STRING" id="1460663.A0A177CP62"/>
    <dbReference type="GeneID" id="28767313"/>
    <dbReference type="InParanoid" id="A0A177CP62"/>
    <dbReference type="OrthoDB" id="5344254at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054499">
        <property type="entry name" value="DA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056402">
        <property type="entry name" value="DA_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22903">
        <property type="entry name" value="DA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24137">
        <property type="entry name" value="DA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159245">
        <property type="entry name" value="AttH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008058454" description="AttH domain-containing protein" evidence="3">
        <location>
            <begin position="18"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="Diels-Alderase N-terminal" evidence="5">
        <location>
            <begin position="31"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="Diels-Alderase C-terminal" evidence="4">
        <location>
            <begin position="231"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00046325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF22903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF24137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAG09325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="385" mass="42397" checksum="022C70418353094B" modified="2016-09-07" version="1">MPSIFLIAILLAAGVTGLTLHTHRCSTNTQVAGTYVNGSVSMNDNPWIHFDAPMTQGFNLTNGEDWSFEGASTDGESGMGFTFSRGTVAGHTLAQRMFFAVVWPNGTRFMESTFADYSTINICRGLIKGTWYNGTSGMNWTFETSEDYSRTVVKVQSATVQGTFTLHARSPAVYPNGLIYPHPHGDNLFAPYLYWVENVPVGVAAANLTIRGTPFVLKGIGGRERNWNSFAWAQVSARWDMFRAKIGPYTLMVWTFESKVDGQTYFSGVLMEEMNVLFRTRTQQVSTTKNYGSFSLQNNGMVRLSSETNSATPLPKSRHTGYLLEMVAPTTGERWRFEVDYTKCVYWFPAGPSARLGGFVGAIKGGLVGGPQHSGRASGTAMEKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CP89</accession>
    <name>A0A177CP89_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Prefoldin beta-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_1162824</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the prefoldin subunit beta family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG09031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039396.1">
        <property type="nucleotide sequence ID" value="XM_018178106.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CP89"/>
    <dbReference type="FunCoup" id="A0A177CP89">
        <property type="interactions" value="765"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CP89"/>
    <dbReference type="GeneID" id="28761592"/>
    <dbReference type="InParanoid" id="A0A177CP89"/>
    <dbReference type="OrthoDB" id="29646at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015631">
        <property type="term" value="F:tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007021">
        <property type="term" value="P:tubulin complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd23163">
        <property type="entry name" value="Prefoldin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.370:FF:000002">
        <property type="entry name" value="Prefoldin subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027235">
        <property type="entry name" value="PFD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002777">
        <property type="entry name" value="PFD_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13303">
        <property type="entry name" value="PREFOLDIN SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01920">
        <property type="entry name" value="Prefoldin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="81"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAG09031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="118" mass="13661" checksum="8E83E2EFD612690A" modified="2016-09-07" version="1">MASQATLKKQQDLQTTYQNYKSTLQTIASKIGDIEQETEEHKLVLETLEPLPGDRKCFRMINGVLTERTVKEVVPILQTNSDGLKKALEELVKQYKSKQEEMEKWKKKNNVQVVQQPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CPD6</accession>
    <name>A0A177CPD6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glycolate oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CC84DRAFT_1171970</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG09385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039750.1">
        <property type="nucleotide sequence ID" value="XM_018179944.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CPD6"/>
    <dbReference type="STRING" id="1460663.A0A177CPD6"/>
    <dbReference type="GeneID" id="28763430"/>
    <dbReference type="InParanoid" id="A0A177CPD6"/>
    <dbReference type="OrthoDB" id="5332616at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004458">
        <property type="term" value="F:D-lactate dehydrogenase (cytochrome) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008720">
        <property type="term" value="F:D-lactate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903457">
        <property type="term" value="P:lactate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.10">
        <property type="entry name" value="FAD-linked oxidases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="entry name" value="Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.45.10">
        <property type="entry name" value="Vanillyl-alcohol Oxidase, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016170">
        <property type="entry name" value="Cytok_DH_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004113">
        <property type="entry name" value="FAD-bd_oxidored_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016164">
        <property type="entry name" value="FAD-linked_Oxase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016171">
        <property type="entry name" value="Vanillyl_alc_oxidase_C-sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11748:SF114">
        <property type="entry name" value="ARYL-ALCOHOL OXIDASE VANILLYL-ALCOHOL OXIDASE (AFU_ORTHOLOGUE AFUA_3G09500)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11748">
        <property type="entry name" value="D-LACTATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02913">
        <property type="entry name" value="FAD-oxidase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55103">
        <property type="entry name" value="FAD-linked oxidases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="5">
        <location>
            <begin position="103"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAG09385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="611" mass="67632" checksum="A9FF3D9213E9245A" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CQ06</accession>
    <name>A0A177CQ06_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">ATP-dependent (S)-NAD(P)H-hydrate dehydratase</fullName>
            <ecNumber evidence="9">4.2.1.93</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">ATP-dependent NAD(P)HX dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CC84DRAFT_1194987</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ATP, which is converted to ADP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>(6S)-NADHX + ATP = ADP + phosphate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19017"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:64074"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="4.2.1.93"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>(6S)-NADPHX + ATP = ADP + phosphate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32231"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="4.2.1.93"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the NnrD/CARKD family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.93" evidence="9"/>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG09022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039387.1">
        <property type="nucleotide sequence ID" value="XM_018181379.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CQ06"/>
    <dbReference type="FunCoup" id="A0A177CQ06">
        <property type="interactions" value="158"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CQ06"/>
    <dbReference type="GeneID" id="28764865"/>
    <dbReference type="InParanoid" id="A0A177CQ06"/>
    <dbReference type="OrthoDB" id="8110916at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047453">
        <property type="term" value="F:ATP-dependent NAD(P)H-hydrate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110051">
        <property type="term" value="P:metabolite repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046496">
        <property type="term" value="P:nicotinamide nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01171">
        <property type="entry name" value="YXKO-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1190.20:FF:000043">
        <property type="entry name" value="ATP-dependent (S)-NAD(P)H-hydrate dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01965">
        <property type="entry name" value="NADHX_dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017953">
        <property type="entry name" value="Carbohydrate_kinase_pred_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000631">
        <property type="entry name" value="CARKD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00196">
        <property type="entry name" value="yjeF_cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12592:SF0">
        <property type="entry name" value="ATP-DEPENDENT (S)-NAD(P)H-HYDRATE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12592">
        <property type="entry name" value="ATP-DEPENDENT (S)-NAD(P)H-HYDRATE DEHYDRATASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01256">
        <property type="entry name" value="Carb_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01049">
        <property type="entry name" value="YJEF_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01050">
        <property type="entry name" value="YJEF_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51383">
        <property type="entry name" value="YJEF_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 9" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 9" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YjeF C-terminal" evidence="10">
        <location>
            <begin position="9"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="172"/>
            <end position="178"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="211"/>
            <end position="215"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="230"/>
            <end position="239"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="240"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OAG09022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="322" mass="34346" checksum="72C356D4145E9666" modified="2016-09-07" version="1">MAGASRKELLGKVYKMIPPMLESFHKGQLGRVAVIGGSEDYTGAPYFSAMASAKLGCDMSHVICEPGAGAVIKTYSPNLMVHPYMRQSKNLASSESIDSVSSEVVGMLSRLHVVVIGPGLGRDKLMQDTCAKVIQEARKRGIPFVLDADGLYLAQTQPELVQGYTECILTPNVVEFGRLAKAKGLKVDELDPTEQCSKLAKAFGGVTIIQKGAKDYISNGTQTLVSEGEGGLKRSGGQGDTLTGSLATLLAYRKAYLDKIWEHDGSLDAAETLALAAYGGSAITRECSRLAFAEKGRSLQAGDLTEHVHQAFLNTVGEKESK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CQF0</accession>
    <name>A0A177CQF0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1212955</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG09536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039901.1">
        <property type="nucleotide sequence ID" value="XM_018182491.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CQF0"/>
    <dbReference type="GeneID" id="28765977"/>
    <dbReference type="InParanoid" id="A0A177CQF0"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="18"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG09536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="111" mass="11984" checksum="2D94F356C36C5C85" modified="2016-09-07" version="1">MSTADSISAANPPTWNTAIVTSTVLAIIALLLGIPGALLAVIKLRRPKRAKRDHIEIGNANHGFAEDQDVQVPPLRLNRTHTSTAYAGLYCFVVSGGEWVQLEYIGKRTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CQX8</accession>
    <name>A0A177CQX8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Short chain dehydrogenase/reductase family protein-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_1212641</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG09177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039542.1">
        <property type="nucleotide sequence ID" value="XM_018182469.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CQX8"/>
    <dbReference type="STRING" id="1460663.A0A177CQX8"/>
    <dbReference type="GeneID" id="28765955"/>
    <dbReference type="InParanoid" id="A0A177CQX8"/>
    <dbReference type="OrthoDB" id="1274115at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051911">
        <property type="entry name" value="SDR_oxidoreductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43976">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43976:SF16">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="335"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="348"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAG09177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="357" mass="39758" checksum="F667E1AE69071FBE" modified="2016-09-07" version="1">MDFDTASQSLSPAAASHNPNLKLPATCDPPSEHSPPKQASWIVFGATGHMGRSLVRALLSHGDKCTAVGWTQENTMEQMKKWEQEKNCVGMLCDVRVRETVDNVIKKSIEHWGHIDVIANCTGYGVIGACEDQDDYDLRNQFNTNFLGTLHIIQLSLPHFRAQNSGRYLIFSSTAGALGVPGLGPYCATKYAVEGLIESMLYEIDCFNIKATLVEPGHVRLDEPDDIVVGSENPGPDGPPKPKRYGHFFVKEKLSEPYNTATSPAGHAKRMIQWLNDRQPVSAVKSAELVWQLGHCSYPPLRLLLGSYAVESVRDRLRSIIEEIEDWKHLSFPVVGPTEEERERGGDEMEQEDQENE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CR20</accession>
    <name>A0A177CR20_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Class I glutamine amidotransferase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1082345</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG09964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040329.1">
        <property type="nucleotide sequence ID" value="XM_018173975.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CR20"/>
    <dbReference type="FunCoup" id="A0A177CR20">
        <property type="interactions" value="110"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CR20"/>
    <dbReference type="GeneID" id="28757461"/>
    <dbReference type="InParanoid" id="A0A177CR20"/>
    <dbReference type="OrthoDB" id="92161at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01741">
        <property type="entry name" value="GATase1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044992">
        <property type="entry name" value="ChyE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42695">
        <property type="entry name" value="GLUTAMINE AMIDOTRANSFERASE YLR126C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42695:SF5">
        <property type="entry name" value="GLUTAMINE AMIDOTRANSFERASE YLR126C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glutamine amidotransferase" evidence="1">
        <location>
            <begin position="63"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG09964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="250" mass="28021" checksum="ECF6A942A4B4DE5E" modified="2016-09-07" version="1">MKPPLRIAILEADTPPDDIVARYGKYGKVFRTLLETAADELGEPGFSKDSLELSAYDVVTEQKYPELDSIDAVLISGSKHNSFDNDPWILKLVEFTEKLLKQDRVRIIGVCFGHQIIGRAAGVKVGRSEGGWEVSVLPVELTEKGKEIFKQDTLSIHQMHRDVVFEYPEGVEPLGGSPRCLVQGMYRKGRFISVQGHPEFTEAIVSYLVTMRNKQGIFNTEEAKDALDRVGHHHDGVPIAKAFLRFLLED</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CR43</accession>
    <name>A0A177CR43_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_1202121</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG09360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039725.1">
        <property type="nucleotide sequence ID" value="XM_018181752.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CR43"/>
    <dbReference type="STRING" id="1460663.A0A177CR43"/>
    <dbReference type="GeneID" id="28765238"/>
    <dbReference type="InParanoid" id="A0A177CR43"/>
    <dbReference type="OrthoDB" id="8117402at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379:SF127">
        <property type="entry name" value="BLOODY FINGERS-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379">
        <property type="entry name" value="KRAB AND ZINC FINGER DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="67"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="325"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="233"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="241"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAG09360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="475" mass="53134" checksum="ABD56E228CB3FCD7" modified="2016-09-07" version="1">MPATLEPIKAFKCTFAGCAASFDMEKQLISHKKNDDEHDYCSNCDLDFESYEDLARHKAFTPDKHGKACRICGEEFKSESGLKRHTELSHKVKQKLPCIGCGEAFPAPALLIEHLEFGHCDVISGQAFMGHVVHGHLVAKLLAGGEAHTRFMQKISQYDASLDQEEEGGVGIENVLEDDHEDAKAVNHPAIQPECSKDEVAHAESWPALSAQGSTAIRSSTVTSAMGRMSLGSLDAGSGIHTMQNPTAPTQNSRHQAKAWGGRSAKELFPQAKPTPAPEKEFSIEAVDEKMEHDHGGNIFNTRFWDPLAKEWDPKRFYNGMIEKYFCPFMCEQCFVDTAELRDHIVVDHRLSRAKCPYCLKYFDSITALMCHCQSRGSKCQVNKADDFGKFLNRLTGGFLSVQEKIRPDFIQNETVMVYNSEAREMEKYTPPTVKYLEYTSSKPMDWRKPTKVAAQIGGGSTSGSFNYKNQQARW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2023-06-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CRS3</accession>
    <name>A0A177CRS3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_449064</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG09668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040033.1">
        <property type="nucleotide sequence ID" value="XM_018186310.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CRS3"/>
    <dbReference type="GeneID" id="28769796"/>
    <dbReference type="InParanoid" id="A0A177CRS3"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG09668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="175" mass="18674" checksum="3C4A0B0B67DFFC26" modified="2016-09-07" version="1">MCMQQGWKSVGLCRLHTVHKLLPCVGLRSKPKPSRMDAPPCLPVSLFHPLSPLIRPHLPGFPKIDSPGPITPTIPLQIGGAQLGFSAPALDATWFGTVGAPVAVPLSVPRCVDLCPAEKSCGMLEVEREFTAMGTGRRRGPFAPSISQPNHFVGVGLRMNVALALTHTPLGETFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CS86</accession>
    <name>A0A177CS86_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Exocyst complex component EXO84</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Exocyst complex component exo84</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CC84DRAFT_1213515</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in the secretory pathway as part of the exocyst complex which tethers secretory vesicles to the sites of exocytosis. Plays a role in both the assembly of the exocyst and the polarization of this complex to specific sites of the plasma membrane for exocytosis. Also involved in assembly of the spliceosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the exocyst complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">Secretory vesicle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EXO84 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040521.1">
        <property type="nucleotide sequence ID" value="XM_018182545.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CS86"/>
    <dbReference type="FunCoup" id="A0A177CS86">
        <property type="interactions" value="175"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CS86"/>
    <dbReference type="GeneID" id="28766031"/>
    <dbReference type="InParanoid" id="A0A177CS86"/>
    <dbReference type="OrthoDB" id="642193at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030133">
        <property type="term" value="C:transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000264">
        <property type="entry name" value="Potential exocyst complex component Exo84"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1220">
        <property type="entry name" value="Exo84p, C-terminal helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1210">
        <property type="entry name" value="Exo84p, N-terminal helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033961">
        <property type="entry name" value="Exo84"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032403">
        <property type="entry name" value="Exo84_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042561">
        <property type="entry name" value="Exo84_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042560">
        <property type="entry name" value="Exo84_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21426">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21426:SF12">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16528">
        <property type="entry name" value="Exo84_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25345">
        <property type="entry name" value="PH_EXO84"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08700">
        <property type="entry name" value="VPS51_Exo84_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="5" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Exocyst component Exo84 C-terminal" evidence="14">
        <location>
            <begin position="470"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="164"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="10"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="46"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="139"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00057052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00065378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00071741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF16528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OAG10156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="688" mass="77555" checksum="B45D43E3A1E42B82" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CSM9</accession>
    <name>A0A177CSM9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Vacuolar ATPase assembly protein VMA22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1139180</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040898.1">
        <property type="nucleotide sequence ID" value="XM_018176227.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CSM9"/>
    <dbReference type="FunCoup" id="A0A177CSM9">
        <property type="interactions" value="50"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CSM9"/>
    <dbReference type="GeneID" id="28759713"/>
    <dbReference type="InParanoid" id="A0A177CSM9"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990871">
        <property type="term" value="C:Vma12-Vma22 assembly complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070072">
        <property type="term" value="P:vacuolar proton-transporting V-type ATPase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040357">
        <property type="entry name" value="Vma22/CCDC115"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31996">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31996:SF2">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21730">
        <property type="entry name" value="Vma22_CCDC115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="99"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="115"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="140"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00093634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG10533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="213" mass="23578" checksum="46B1BDC09CE244D2" modified="2016-09-07" version="1">MADVALPVSASEIQSSVPGKDELLLRLDDLLERYLHTLDAYQKAQQQLTKHLSSGYLSLAQANFNNNAHTRYGQDYFDERMQASRKFVICEDEGTTTISVASQNAEDPTDKTKDTSSPADSSATAREAEEVPEADAQGPFEEKTNSAVPETKKTPTNDPLRWFGVLVPPALRSAQASFVTAVEGPVTELSNLLRELRQQEIEIGRVRKQIKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CU03</accession>
    <name>A0A177CU03_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Aldehyde dehydrogenase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_1161594</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="4">Alcohol metabolism; ethanol degradation; acetate from ethanol: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041091.1">
        <property type="nucleotide sequence ID" value="XM_018177781.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CU03"/>
    <dbReference type="STRING" id="1460663.A0A177CU03"/>
    <dbReference type="GeneID" id="28761267"/>
    <dbReference type="InParanoid" id="A0A177CU03"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046394">
        <property type="term" value="P:carboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006598">
        <property type="term" value="P:polyamine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07144">
        <property type="entry name" value="ALDH_ALD2-YMR170C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000011">
        <property type="entry name" value="ALD5p Mitochondrial aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000026">
        <property type="entry name" value="Aldehyde dehydrogenase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000012">
        <property type="entry name" value="Betaine aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43720">
        <property type="entry name" value="2-AMINOMUCONIC SEMIALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43720:SF2">
        <property type="entry name" value="2-AMINOMUCONIC SEMIALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="2 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="7">
        <location>
            <begin position="28"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00037885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAG10726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="501" mass="54540" checksum="754C57F317C5EB22" modified="2016-09-07" version="1">MSDLFVELTAPNGHKYKQPRGLFINNEFVKSQSGETITSINPSNESEITSVYAAGPEDVDTAVAAARKAFKDPSWRDMDTNARADLLYNFAQLIEKHRETLATIETWDNGKPYQVSLNDDLGEVISTIKYYAGYANKIHGQVIDTSPAKLAYTVREPLGVCAQIIPWNFPLAMAAWKLGPALCTGNTVVMKAAEQTPLSILYLASLVKEAGFPPGVINILNGEGRKAGAALAQHMDVDKIAFTGSTATGKEIMKMAAVNMKNITLETGGKSPLLVFDDADLDQAVKWSHVGIMYNQGQVCTATSRILVQEGIYDKFVESFKEYVSKASVVGDPFKDDTFQGPQVTKTQFERVLSYIESGKSEGAKLISGGEAFKDVGGKGFFIAPTIFTDVKDDMKIYREEVFGPFVVVSSFKTEEEAIERANDSCYGLGAALFTQDITKAHTVARRIEAGMVWINSSNDSDVRVPFGGVKQSGIGRELGEAGLEAYTNKKAIHVNLGSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2023-06-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CU39</accession>
    <name>A0A177CU39_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_516921</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG11033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041398.1">
        <property type="nucleotide sequence ID" value="XM_018186574.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CU39"/>
    <dbReference type="GeneID" id="28770060"/>
    <dbReference type="InParanoid" id="A0A177CU39"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG11033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="176" mass="20339" checksum="2733182AB85A7F51" modified="2016-09-07" version="1">MAWRLLFKNSIIVKKELRVSFRSERSAWLDRLSLLELRSSVVGWRGSFGLLHLTSGVIRQGSKDTTGSRYVSTDTFILWYELRRSREEAVWKCVSVGSVLKSFGRSAVVRGRMVDAGCRRGNRRRWASRKGIVERVNATEYEVFDLPSYDALIRELRRLLAELFVGYFAAGRTFCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CUX8</accession>
    <name>A0A177CUX8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glyoxal oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CC84DRAFT_1139224</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040924.1">
        <property type="nucleotide sequence ID" value="XM_018176230.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CUX8"/>
    <dbReference type="STRING" id="1460663.A0A177CUX8"/>
    <dbReference type="GeneID" id="28759716"/>
    <dbReference type="InParanoid" id="A0A177CUX8"/>
    <dbReference type="OrthoDB" id="2019572at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00035">
        <property type="entry name" value="ChtBD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11618">
        <property type="entry name" value="ChtBD1_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd02851">
        <property type="entry name" value="E_set_GO_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.10">
        <property type="entry name" value="Endochitinase-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.80">
        <property type="entry name" value="Galactose oxidase/kelch, beta-propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001002">
        <property type="entry name" value="Chitin-bd_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036861">
        <property type="entry name" value="Endochitinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037293">
        <property type="entry name" value="Gal_Oxidase_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009880">
        <property type="entry name" value="Glyoxal_oxidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015202">
        <property type="entry name" value="GO-like_E_set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32208:SF21">
        <property type="entry name" value="LOW QUALITY PROTEIN: ALDEHYDE OXIDASE GLOX-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32208">
        <property type="entry name" value="SECRETED PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00187">
        <property type="entry name" value="Chitin_bind_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07250">
        <property type="entry name" value="Glyoxal_oxid_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09118">
        <property type="entry name" value="GO-like_E_set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00270">
        <property type="entry name" value="ChtBD1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="Galactose oxidase, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57016">
        <property type="entry name" value="Plant lectins/antimicrobial peptides"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50941">
        <property type="entry name" value="CHIT_BIND_I_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Chitin-binding type-1" evidence="5">
        <location>
            <begin position="94"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-1" evidence="5">
        <location>
            <begin position="163"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-1" evidence="5">
        <location>
            <begin position="256"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="219"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="221"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="241"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="117"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="184"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="204"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="276"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAG10559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="832" mass="87391" checksum="370A3CE04FEB5CD8" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CUZ1</accession>
    <name>A0A177CUZ1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">EthD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1237667</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the tpcK family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041055.1">
        <property type="nucleotide sequence ID" value="XM_018183909.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CUZ1"/>
    <dbReference type="STRING" id="1460663.A0A177CUZ1"/>
    <dbReference type="GeneID" id="28767395"/>
    <dbReference type="InParanoid" id="A0A177CUZ1"/>
    <dbReference type="OrthoDB" id="3183782at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009799">
        <property type="entry name" value="EthD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07110">
        <property type="entry name" value="EthD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EthD" evidence="2">
        <location>
            <begin position="19"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG10690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="133" mass="15278" checksum="B213F077128D91F0" modified="2016-09-07" version="1">MGEPANLPYIRVQLCIKKKDEVSDKFFHDYWKGNHVKLALENKKFVDKVIRYNQFHTSPSLKAQAGEFKIPVPEYDGIAEVWVKDIETWKEIATDPDFIATIAPDEDNFIKAPIHIMLGYDNTVIGDAVKNKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CV08</accession>
    <name>A0A177CV08_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DNA primase large subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CC84DRAFT_1161525</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="9">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the eukaryotic-type primase large subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040992.1">
        <property type="nucleotide sequence ID" value="XM_018177762.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CV08"/>
    <dbReference type="FunCoup" id="A0A177CV08">
        <property type="interactions" value="892"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CV08"/>
    <dbReference type="GeneID" id="28761248"/>
    <dbReference type="InParanoid" id="A0A177CV08"/>
    <dbReference type="OrthoDB" id="421393at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005658">
        <property type="term" value="C:alpha DNA polymerase:primase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006269">
        <property type="term" value="P:DNA replication, synthesis of primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd07322">
        <property type="entry name" value="PriL_PriS_Eukaryotic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.930.80:FF:000003">
        <property type="entry name" value="DNA primase large subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058560">
        <property type="entry name" value="DNA_primase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016558">
        <property type="entry name" value="DNA_primase_lsu_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007238">
        <property type="entry name" value="DNA_primase_lsu_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10537">
        <property type="entry name" value="DNA PRIMASE LARGE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10537:SF3">
        <property type="entry name" value="DNA PRIMASE LARGE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04104">
        <property type="entry name" value="DNA_primase_lrg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26466">
        <property type="entry name" value="DNA_primase_lrg_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009449">
        <property type="entry name" value="DNA_primase_large_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9 10" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4 9" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 9 10" id="KW-0408">Iron</keyword>
    <keyword evidence="7 9 10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5 9 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 9" id="KW-0639">Primosome</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA primase large subunit C-terminal" evidence="11">
        <location>
            <begin position="297"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="302"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="385"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="402"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="443"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR009449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR009449-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF04104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OAG10627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="503" mass="58634" checksum="3C9B6B66C6604F47" modified="2016-09-07" version="1">MIRHDYSRVEPKRRAYIDPKKRQFAKAEFAQQNYEHRLNFYTLPPTAEITLEEFETWAINRLKVLSELEACSFRNRSQEETAEYMTSILNKYLPLRSNSSRGANLQEERKRDHYSHFILRLAFSSTEDLRRRFSHLETILFRLRFREDDPRERQDFVRTLDLEWEEVGEDEKRELRGQMLAAIGSKKGEEQDWFKVDWERVPELVSQRKVLLKRGMAYVPAREQTSLVVAEFTKRLDEQLELTARALPRLDEDDRLAPILAHLSQSFTAPEAAYSSSDANIDGLSAINAGAIDTLSQNFPLCMQNLHMTLRANSHLKHYGRLQYTLFLKGIGLSLEECIIFWRRSFKLMTDDKFHKEYKYNIRHSYGDVGGDANRRGRGYTPYSCQKILTEALPGPGQTHGCPYRTFTVENLTGLLQRVGVQDRETLQGVREDVKKQRYHVACNRVFESVHKKEIKKVKDEGSWSATDLDTIVHPNTYFKRSWLLKHLGEGNAGIVGGDKMEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CV75</accession>
    <name>A0A177CV75_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HET-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1161733</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041283.1">
        <property type="nucleotide sequence ID" value="XM_018177822.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CV75"/>
    <dbReference type="STRING" id="1460663.A0A177CV75"/>
    <dbReference type="GeneID" id="28761308"/>
    <dbReference type="InParanoid" id="A0A177CV75"/>
    <dbReference type="OrthoDB" id="2958217at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF10">
        <property type="entry name" value="TOL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="397"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG10918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="887" mass="100995" checksum="0E1C43843872B420" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CVN5</accession>
    <name>A0A177CVN5_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CC84DRAFT_1159103</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG11615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041980.1">
        <property type="nucleotide sequence ID" value="XM_018177140.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CVN5"/>
    <dbReference type="STRING" id="1460663.A0A177CVN5"/>
    <dbReference type="GeneID" id="28760626"/>
    <dbReference type="InParanoid" id="A0A177CVN5"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004713">
        <property type="term" value="F:protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110031">
        <property type="term" value="P:negative regulation of G2/MI transition of meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050339">
        <property type="entry name" value="CC_SR_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE EIF2-ALPHA KINASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042:SF190">
        <property type="entry name" value="MITOSIS INHIBITOR PROTEIN KINASE MIK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="148"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="350"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="458"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="561"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="374"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="390"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="470"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="575"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="599"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="631"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="662"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="694"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="706"/>
            <end position="715"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAG11615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="715" mass="80275" checksum="FB734340489D727A" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CVS0</accession>
    <name>A0A177CVS0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Amidohydrolase-like protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CC84DRAFT_1214175</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallo-dependent hydrolases superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041252.1">
        <property type="nucleotide sequence ID" value="XM_018182608.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CVS0"/>
    <dbReference type="STRING" id="1460663.A0A177CVS0"/>
    <dbReference type="GeneID" id="28766094"/>
    <dbReference type="InParanoid" id="A0A177CVS0"/>
    <dbReference type="OrthoDB" id="432010at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032465">
        <property type="entry name" value="ACMSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240">
        <property type="entry name" value="2-AMINO-3-CARBOXYLMUCONATE-6-SEMIALDEHYDE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240:SF31">
        <property type="entry name" value="AMIDOHYDROLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_7G05840)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="4">
        <location>
            <begin position="46"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU366045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAG10887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="342" mass="38774" checksum="7F12D4AD00FCF2DF" modified="2016-09-07" version="1">MKGTIAVEEAIIDQAGVEAHSFAQFQNLMRPGSDPTTGLSAHEKRLLDIHGERLKSMDEHGVEYMLLSLTSPGAQGEADPGKAKEIARVANDYLAGEVRKNPTRFGALAALSMHNAKDAADELRRAVRELGMFGGLVNDFQSQGADAEEKVYFDTPDYDPFWQTVEELDVPIYFHPRYAILQDLREGTKYGDRKHLLGAGVQFHLDLSWHLYAICSSGIFDRFPKVQIVAGHLGEGIPFNLWRASHWINHPFKRGSRPMKEDYSYYWTHNVNITTSGNYNTKGLKFCIEEIGLERCLYAIDTPYETVEEGQQWWKLVDLPEDQKEAVARKNAIRLFKLPLEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CVS6</accession>
    <name>A0A177CVS6_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Alternative oxidase</fullName>
            <ecNumber evidence="17">1.-.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">CC84DRAFT_1158872</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Catalyzes cyanide-resistant oxygen consumption. May increase respiration when the cytochrome respiratory pathway is restricted, or in response to low temperatures.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="16 17">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="16 17">Binds 2 iron ions per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 17">Belongs to the alternative oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="17"/>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG11321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041686.1">
        <property type="nucleotide sequence ID" value="XM_018177086.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CVS6"/>
    <dbReference type="STRING" id="1460663.A0A177CVS6"/>
    <dbReference type="GeneID" id="28760572"/>
    <dbReference type="InParanoid" id="A0A177CVS6"/>
    <dbReference type="OrthoDB" id="16906at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098803">
        <property type="term" value="C:respiratory chain complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009916">
        <property type="term" value="F:alternative oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010230">
        <property type="term" value="P:alternative respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01053">
        <property type="entry name" value="AOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1260.140:FF:000002">
        <property type="entry name" value="Alternative oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.140">
        <property type="entry name" value="Alternative oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002680">
        <property type="entry name" value="AOX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038659">
        <property type="entry name" value="AOX_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31803">
        <property type="entry name" value="ALTERNATIVE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31803:SF3">
        <property type="entry name" value="ALTERNATIVE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01786">
        <property type="entry name" value="AOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005229">
        <property type="entry name" value="AOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 17" id="KW-0249">Electron transport</keyword>
    <keyword evidence="12 16 17" id="KW-0408">Iron</keyword>
    <keyword evidence="14 17 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 16 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11 17" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 17" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="5 17 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 19" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="217"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="324"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="333"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="253"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="308"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="308"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="311"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00025285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR005229-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU003779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="OAG11321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="360" mass="41688" checksum="F2C56FE048B95A74" modified="2016-09-07" version="1">MICTRVTANGPRASRQASAQFIKTLNCLNASGAGLRPTFVAVHHIQLSAAPQRHFSNTSRSSRIDEYFPQKETEKVRKTPSAWPHPVYSYNDMESVIVAHREAKTRSDRVALLAVKVLRWGLDLATGYKHDKAVALNEKDPEAARRKYAMTEEKYMMRNVFLESVAGVPGMVAGMIRHLHSMRRMKRDNGWIESLLEESYNERMHLLTFLKMSEPGWFMRFLVLGAQGVWCNALFFAYLISPRTVHRFVGYLEEEAVITYTRQLKDLDAGRLPKWEKLQAPQIAIDYWNMPEGHQSMRDLLLYIRADESKHREVNHTLGNLDQVEDPNPYVSEYKDSERPHPRKDLKFQRPTGWERSDII</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2023-06-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CW11</accession>
    <name>A0A177CW11_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_518692</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG11082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041447.1">
        <property type="nucleotide sequence ID" value="XM_018186591.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CW11"/>
    <dbReference type="GeneID" id="28770077"/>
    <dbReference type="InParanoid" id="A0A177CW11"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG11082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="156" mass="17714" checksum="13B2EC826D63FDDF" modified="2016-09-07" version="1">MWAPWCQSVDDGWSVWNEEPRRQGGGHGWAWSQCLLLFFFVLRDSFFVGLDMHVAGGRQPTLVTRQGFDTHAPNQPCPVCFISHREPRSPTFSYPSRTPSSCAVIPSRKGAHTTLPMYSKRTIRYAPVHSSPRRTCKWAFVIGDRLTDVVCQGCQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CW84</accession>
    <name>A0A177CW84_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CC84DRAFT_1140075</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAH family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG11077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041442.1">
        <property type="nucleotide sequence ID" value="XM_018176271.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CW84"/>
    <dbReference type="FunCoup" id="A0A177CW84">
        <property type="interactions" value="1023"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CW84"/>
    <dbReference type="GeneID" id="28759757"/>
    <dbReference type="InParanoid" id="A0A177CW84"/>
    <dbReference type="OrthoDB" id="284275at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000439">
        <property type="term" value="C:transcription factor TFIIH core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018773">
        <property type="term" value="F:acetylpyruvate hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050163">
        <property type="term" value="F:oxaloacetate tautomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006107">
        <property type="term" value="P:oxaloacetate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.850.10:FF:000002">
        <property type="entry name" value="2-hydroxyhepta-2,4-diene-1,7-dioate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="entry name" value="Fumarylacetoacetase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007198">
        <property type="entry name" value="Ssl1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004595">
        <property type="entry name" value="TFIIH_C1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012170">
        <property type="entry name" value="TFIIH_SSL1/p44"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00622">
        <property type="entry name" value="ssl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11820">
        <property type="entry name" value="ACYLPYRUVASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11820:SF7">
        <property type="entry name" value="ACYLPYRUVASE FAHD1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07975">
        <property type="entry name" value="C1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04056">
        <property type="entry name" value="Ssl1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01047">
        <property type="entry name" value="C1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="FAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="C2H2-type" evidence="5">
        <location>
            <begin position="418"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="43"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="60"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAG11077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="740" mass="81692" checksum="2721F939D2458B00" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CW90</accession>
    <name>A0A177CW90_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1211420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG11783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042148.1">
        <property type="nucleotide sequence ID" value="XM_018182380.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CW90"/>
    <dbReference type="GeneID" id="28765866"/>
    <dbReference type="InParanoid" id="A0A177CW90"/>
    <dbReference type="OrthoDB" id="5424462at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053203">
        <property type="entry name" value="Cisplatin_resist-associated"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022024">
        <property type="entry name" value="DUF3602"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34693:SF2">
        <property type="entry name" value="DUF3602 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34693">
        <property type="entry name" value="PROTEIN PAR32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12223">
        <property type="entry name" value="DUF3602"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG11783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="149" mass="15911" checksum="3727EB55120892F8" modified="2016-09-07" version="1">MVSYHIAEPHPSASSSAYYGRGGAGNVTRIPKNVTPGPDASGPASRIKLSPPSNALFTSGRGGAGNIHREKERAMFSFDEELAAQERLREHAAPVYHIGRGGAGNLVEERVKTSRQNSSASTASTDSERGVRGSIEGAWRKMSRQFSNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CWR4</accession>
    <name>A0A177CWR4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Dabb-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1078975</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG11169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041534.1">
        <property type="nucleotide sequence ID" value="XM_018173816.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CWR4"/>
    <dbReference type="STRING" id="1460663.A0A177CWR4"/>
    <dbReference type="GeneID" id="28757302"/>
    <dbReference type="InParanoid" id="A0A177CWR4"/>
    <dbReference type="OrthoDB" id="1601230at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013097">
        <property type="entry name" value="Dabb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044662">
        <property type="entry name" value="HS1/DABB1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33178">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33178:SF10">
        <property type="entry name" value="STRESS-RESPONSE A_B BARREL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07876">
        <property type="entry name" value="Dabb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00886">
        <property type="entry name" value="Dabb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51502">
        <property type="entry name" value="S_R_A_B_BARREL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Stress-response A/B barrel" evidence="2">
        <location>
            <begin position="6"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG11169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="113" mass="12957" checksum="01A9B6221FA2075C" modified="2016-09-07" version="1" fragment="single">MALDNIMHIVLFKYRTDVTWSDLEDHFKSFMSLKTRSLHPQSGLPLIKSLRAGKNTSWEPFSKGMTHAFILEFASQDDLDYYLTAEPVHVQFSKDAKPLIEDSLVVDIRDGVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CXW4</accession>
    <name>A0A177CXW4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1159141</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG11667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042032.1">
        <property type="nucleotide sequence ID" value="XM_018177149.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CXW4"/>
    <dbReference type="GeneID" id="28760635"/>
    <dbReference type="InParanoid" id="A0A177CXW4"/>
    <dbReference type="OrthoDB" id="3797593at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="286"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="293"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG11667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="468" mass="50897" checksum="1DB0EB4C7803A97D" modified="2016-09-07" version="1">MANAQPDETDLKVALKLAAVVRDVNAVERVLDTEISPSAKVIVARVIIGKLGIATADRHLRRLLSRPQFKVIVAVALELLYSGEGDLELIESMLGISMTHQMRGVTDSVSLQQLKPSLAHPRLMGLINISFPALRQDSTPNGPGSASSANTSPPGVAGITTSYLTSHAPARIDVNPFAPAANMQSLAQGRPVRQRERALSLVSLSRDEDYGGGGGCNTTHPYAAAHEPSVGSPRTSALMAATTNTSPSPYAMMTDPHLTNHSPSRLDLNQIPPVANMFPAAGLSSPFTTLPVDPRKRTRSGEDMNDDNRRDIKRVAGPVVLARGKVDAYWTFADMIQHIILLTRGPPSAWQQNSIRVPKEAGLFPRTYVTPYNSNHPDKQGKTEPSLYGAQQHQDLGLCFGTWCREGQCLVGEHCPWRHYLDKYTIGFIWRSGAGHEGHHFLKKALKHLQAGPCRPVHTHVPIPNLKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CXZ5</accession>
    <name>A0A177CXZ5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1080688</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG11918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042283.1">
        <property type="nucleotide sequence ID" value="XM_018173903.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CXZ5"/>
    <dbReference type="GeneID" id="28757389"/>
    <dbReference type="InParanoid" id="A0A177CXZ5"/>
    <dbReference type="OrthoDB" id="3934814at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG11918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="212" mass="23939" checksum="B8FC604599930577" modified="2016-09-07" version="1" fragment="single">NSNGREVQAVMSLLAKPKGDEKEVHQVRKKVAEDRRALNTLLQRRLEQAERRDVHRQSEMSAVIAKALTKPNKTTSREPMTFETTRIACNSIYHSALRVDAARRSMLFEYAGLEATIAKMGGDHMNTVTEKWVQDIGREDRLLRLGHKTAVKRVKKVLGAKAPGQETLVEETEGEEKGIGVQDELNMELLQGLKYAERGIKRMVKGVPKDCY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CY27</accession>
    <name>A0A177CY27_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1254719</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042830.1">
        <property type="nucleotide sequence ID" value="XM_018184483.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CY27"/>
    <dbReference type="GeneID" id="28767969"/>
    <dbReference type="InParanoid" id="A0A177CY27"/>
    <dbReference type="OrthoDB" id="3779526at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35391">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35391:SF3">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G04300)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="145"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="176"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="220"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="421"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="421"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG12465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="490" mass="55203" checksum="CE9557DA9BAC94FF" modified="2016-09-07" version="1">MGADQKYDEESLQHVYALLRRYRSNDVIRMVLDVAQSRPASTITSASRLSHLSSESRYSGFSTDYAPSLQSSASSRSQPQHATPLYRSDLSFTKPAMASASPISEAFSPADTLSIPSPLPVDIDSRSITSSTPKRNTTSLNGGPWFCTFCTEPTSFAAKADWKKHETKQHETGEDWPCPIHNCLEVLDRKLDFEAHFKRDHPHVPCPTDVRVRLLPRLVYGCGFDGCKAVLTGWKERCDHVALHMRPKGTEKRKGRSEWKYSNTIHNLLRQDATRSAWKSLFAEFESKQPRYQITWSPENTRILRQKLECSDMRPNILEVVHTALSLREGRPFNDAVELDTDFRTPSQDSVPGFELLSDDQLNQILSGRIEQPAPTMRPALPSHTLDPKLTFMEPHPGDLVAFDIPSPTISGRRISYMDVDTEDFGPSDEGPDPQIPPGLELDPSQMCYGASPKPFQLYYPHGPTVEGMPQQRRTSKGHILTRHFKGRKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CYV4</accession>
    <name>A0A177CYV4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Proteasome activator subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CC84DRAFT_92396</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the BLM10 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042613.1">
        <property type="nucleotide sequence ID" value="XM_018187899.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A177CYV4">
        <property type="interactions" value="329"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CYV4"/>
    <dbReference type="GeneID" id="28771385"/>
    <dbReference type="InParanoid" id="A0A177CYV4"/>
    <dbReference type="OrthoDB" id="17907at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016504">
        <property type="term" value="F:peptidase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010499">
        <property type="term" value="P:proteasomal ubiquitin-independent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032430">
        <property type="entry name" value="Blm10_mid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032372">
        <property type="entry name" value="Blm10_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055455">
        <property type="entry name" value="HEAT_PSME4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035309">
        <property type="entry name" value="PSME4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021843">
        <property type="entry name" value="PSME4_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32170">
        <property type="entry name" value="PROTEASOME ACTIVATOR COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32170:SF3">
        <property type="entry name" value="PROTEASOME ACTIVATOR COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16547">
        <property type="entry name" value="BLM10_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23096">
        <property type="entry name" value="HEAT_PSME4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16507">
        <property type="entry name" value="HEAT_PSME4_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11919">
        <property type="entry name" value="PSME4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Proteasome activator Blm10 N-terminal" evidence="12">
        <location>
            <begin position="21"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="Proteasome activator Blm10 middle HEAT repeats region" evidence="11">
        <location>
            <begin position="382"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="domain" description="Proteasome activator complex subunit 4-like HEAT repeat-like" evidence="13">
        <location>
            <begin position="1377"/>
            <end position="1586"/>
        </location>
    </feature>
    <feature type="domain" description="Proteasome activator complex subunit 4 C-terminal" evidence="10">
        <location>
            <begin position="1879"/>
            <end position="1967"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="14"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF11919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF16507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF16547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF23096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OAG12248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1967" mass="222943" checksum="91FCA45808667A85" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CZE7</accession>
    <name>A0A177CZE7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_163932</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018043248.1">
        <property type="nucleotide sequence ID" value="XM_018185436.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CZE7"/>
    <dbReference type="STRING" id="1460663.A0A177CZE7"/>
    <dbReference type="GeneID" id="28768922"/>
    <dbReference type="InParanoid" id="A0A177CZE7"/>
    <dbReference type="OrthoDB" id="3350591at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022085">
        <property type="entry name" value="OpdG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053204">
        <property type="entry name" value="Oxopyrrolidines_Biosynth-assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38797:SF6">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38797">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP85-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12311">
        <property type="entry name" value="DUF3632"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG12883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="265" mass="30152" checksum="496D2DC62A494761" modified="2016-09-07" version="1">MAPAILASFLAQLEQKPEFKIIHTLFLDPDADPSAVAEKIVELTIPYFSRPNSASMWEDDEPHLFHTACSVIEVAQRTPPERQDKLCDFVMALKQHSLNDTKTGKPLMDGGAKVWTDLPAFGYTFADCTQFMSGYDKKTSEEAQQDENLEAFLAKLTGDPRDRTVDLSDRGQLAMSRAFYLETAQIPPGRAVHTIRLGCWWFIRAAAALWANVQDPKNDNWSLELWNFYKEGLLTRKAEIRNHEVRKMIEQAIEEMEKAERGNSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CZT7</accession>
    <name>A0A177CZT7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">RSC complex subunit Rsc9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_1201252</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042554.1">
        <property type="nucleotide sequence ID" value="XM_018181710.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CZT7"/>
    <dbReference type="STRING" id="1460663.A0A177CZT7"/>
    <dbReference type="GeneID" id="28765196"/>
    <dbReference type="InParanoid" id="A0A177CZT7"/>
    <dbReference type="OrthoDB" id="338531at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016586">
        <property type="term" value="C:RSC-type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16100">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.60:FF:000021">
        <property type="entry name" value="Chromatin structure-remodeling complex subunit rsc9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.60">
        <property type="entry name" value="ARID DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001606">
        <property type="entry name" value="ARID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036431">
        <property type="entry name" value="ARID_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052406">
        <property type="entry name" value="Chromatin_Remodeling_Comp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003150">
        <property type="entry name" value="DNA-bd_RFX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22970">
        <property type="entry name" value="AT-RICH INTERACTIVE DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22970:SF14">
        <property type="entry name" value="AT-RICH INTERACTIVE DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01388">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01014">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00501">
        <property type="entry name" value="BRIGHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46774">
        <property type="entry name" value="ARID-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51011">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51526">
        <property type="entry name" value="RFX_DBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="ARID" evidence="6">
        <location>
            <begin position="16"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="RFX-type winged-helix" evidence="7">
        <location>
            <begin position="616"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="136"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="929"/>
            <end position="990"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="146"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="166"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="210"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="965"/>
            <end position="981"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAG12189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1038" mass="116543" checksum="138DEF47FC3B1B25" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CZT9</accession>
    <name>A0A177CZT9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Leptomycin B resistance protein pmd1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CC84DRAFT_1108699</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042735.1">
        <property type="nucleotide sequence ID" value="XM_018175206.1"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CZT9"/>
    <dbReference type="GeneID" id="28758692"/>
    <dbReference type="InParanoid" id="A0A177CZT9"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015421">
        <property type="term" value="F:ABC-type oligopeptide transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090374">
        <property type="term" value="P:oligopeptide export from mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18577">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18578">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000057">
        <property type="entry name" value="ABC multidrug transporter SitT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000913">
        <property type="entry name" value="ABC multidrug transporter SitT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394">
        <property type="entry name" value="ATP-DEPENDENT PERMEASE MDL1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394:SF27">
        <property type="entry name" value="ATP-DEPENDENT TRANSLOCASE ABCB1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="88"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="161"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="186"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="266"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="307"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="717"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="768"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="835"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="864"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="948"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="35"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="370"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="722"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="1067"/>
            <end position="1308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="652"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="652"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="672"/>
            <end position="685"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OAG12370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="1312" mass="141427" checksum="4533F2D4CF73EB2B" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177D029</accession>
    <name>A0A177D029_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">G-protein coupled receptors family 2 profile 2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CC84DRAFT_1255199</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG13074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018043439.1">
        <property type="nucleotide sequence ID" value="XM_018184516.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177D029"/>
    <dbReference type="STRING" id="1460663.A0A177D029"/>
    <dbReference type="GeneID" id="28768002"/>
    <dbReference type="InParanoid" id="A0A177D029"/>
    <dbReference type="OrthoDB" id="100006at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022343">
        <property type="entry name" value="GCR1-cAMP_receptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023041">
        <property type="entry name" value="Glucose_rcpt_Git3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022596">
        <property type="entry name" value="GPR1/2/3_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR 157-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112:SF0">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 116"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11710">
        <property type="entry name" value="Git3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11970">
        <property type="entry name" value="GPR_Gpa2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02001">
        <property type="entry name" value="GCR1CAMPR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="30"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="64"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="111"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="141"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="6">
        <location>
            <begin position="27"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAG13074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="389" mass="43374" checksum="A1A677F51B421C4B" modified="2016-09-07" version="1">MDTSDVSQFARRAVLSAPASPQQIQILNQVILAVSALSITGAGWIILSFCLFKEVRTFRHQLILGLAISDFFMAVNFLSSCAANLSGYSIGKHQAFCSFNGFLTQFFVVQTDYWVITIAICTFLILANYKHQASWIQEHRILLWCIPWCLSILWAALGVGLDGYSNIGAWCWFGSDKTRLLVNFVPRWVIIIAMLGLYVRLYRIIYRAHEQFISFQDESSSHGIPGISSETGSSTRRIGRPSTSMHITSKDGTIEVERHGTGAVTNGQTHLGRPSTVLKKLAKQMMYYPLAYMVIWTIPTTIRIYQSVTGVPAPFGIATVDKACIVVQGFADAIIYGLNESSKSVWRNKFRKTSPTAPAPMHVNVEHEIRVERLSVIQTDSGRSSVHIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177D0R9</accession>
    <name>A0A177D0R9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CC84DRAFT_157786</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type III membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the OST4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018043095.1">
        <property type="nucleotide sequence ID" value="XM_018185409.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177D0R9"/>
    <dbReference type="GeneID" id="28768895"/>
    <dbReference type="InParanoid" id="A0A177D0R9"/>
    <dbReference type="OrthoDB" id="2124077at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008250">
        <property type="term" value="C:oligosaccharyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018279">
        <property type="term" value="P:protein N-linked glycosylation via asparagine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018943">
        <property type="entry name" value="Oligosaccaryltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051307">
        <property type="entry name" value="OST4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036330">
        <property type="entry name" value="Ost4p_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48164">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48164:SF1">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10215">
        <property type="entry name" value="Ost4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103464">
        <property type="entry name" value="Oligosaccharyltransferase subunit ost4p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAG12730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="50" mass="5521" checksum="E70E2E2B247B23F6" modified="2016-09-07" version="1">MITDNQLYTLAIFLGSASMLLIVLYHFLEVNSEDHVAEEKPRTAAGKAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BSW7</accession>
    <name>A0A177BSW7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1182178</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441578">
        <property type="protein sequence ID" value="OAF98463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018028829.1">
        <property type="nucleotide sequence ID" value="XM_018180611.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BSW7"/>
    <dbReference type="GeneID" id="28764097"/>
    <dbReference type="InParanoid" id="A0A177BSW7"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="91"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAF98463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="126" mass="13678" checksum="5ED44E2D03FC5A0A" modified="2016-09-07" version="1">MPTPLKHHAAGQRQGYQDDSPKGGGNITITKEDRRTAAGNNENKGDADLARLVSIRSGSRSPTPRNRAPQKEGLGGTPGSRDEVQHTSKVPGTPMGPGTPMAWRDPNEESEDHKGWDDWYIVPDIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2023-06-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BUK7</accession>
    <name>A0A177BUK7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_419315</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441563">
        <property type="protein sequence ID" value="OAF99143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029509.1">
        <property type="nucleotide sequence ID" value="XM_018186144.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BUK7"/>
    <dbReference type="GeneID" id="28769630"/>
    <dbReference type="InParanoid" id="A0A177BUK7"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAF99143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="199" mass="23223" checksum="6957D45C00F4F31B" modified="2016-09-07" version="1">MFLSVSVLNVPFRPENFSTALPSYANNPRELELRGHAARTRDNQGEGFQQWRSQGQTTDFSRLKSLRKSTVISTVWFNPSRDKPRGFWWNGDSRLGTYKLVPYSLEKLTMEFEYLMYTFPVGDMYYDTFVFWSPNQQQKGFGWILGISQHSPRYPTLKSLNLTEAKRLSIPGTLVPSRLWPQSRTLAEQDSHQYHQICL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BV75</accession>
    <name>A0A177BV75_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">5'-3' DNA helicase ZGRF1-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1264228</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441562">
        <property type="protein sequence ID" value="OAF99214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029580.1">
        <property type="nucleotide sequence ID" value="XM_018185294.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BV75"/>
    <dbReference type="STRING" id="1460663.A0A177BV75"/>
    <dbReference type="GeneID" id="28768780"/>
    <dbReference type="InParanoid" id="A0A177BV75"/>
    <dbReference type="OrthoDB" id="6513042at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052800">
        <property type="entry name" value="DNA_Repair_Helicase_ZGRF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018838">
        <property type="entry name" value="ZGRF1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28535:SF1">
        <property type="entry name" value="PROTEIN ZGRF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28535">
        <property type="entry name" value="ZINC FINGER GRF-TYPE CONTAINING 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10382">
        <property type="entry name" value="ZGRF1-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="5'-3' DNA helicase ZGRF1-like N-terminal" evidence="2">
        <location>
            <begin position="23"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="486"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="243"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="346"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="504"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="558"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="649"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="681"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="725"/>
            <end position="737"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAF99214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="838" mass="91115" checksum="E6C97F3BFD589E75" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BVL4</accession>
    <name>A0A177BVL4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CC84DRAFT_386104</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441562">
        <property type="protein sequence ID" value="OAF99195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029561.1">
        <property type="nucleotide sequence ID" value="XM_018186000.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BVL4"/>
    <dbReference type="GeneID" id="28769486"/>
    <dbReference type="InParanoid" id="A0A177BVL4"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000145">
        <property type="entry name" value="Zinc finger protein 574"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="360"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="293"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="293"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAF99195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="429" mass="47866" checksum="63BED78139F9911A" modified="2016-09-07" version="1">MKGGQTDPGWGGGMSAVGRGAQAESSGGHKEYELALQSTNTDIQVRYVDRQDEPSSYPYWVITDNTTPKYDPYRGFWSRDRKEVESDSIGKATTTTELTHDVVADDSIAGTADDVDYAASDVEDEEDSEQFLRGAAATRNKKSVRFAEMRLFRTSFPSSMSNPSKSDDFTAQISAPQLGTERANRPVRAAARKAKLNNPASDVSANISSEARRISQVAERDYAFDVDNTVARVRVTRDRGLRVRQTKPDNALYASLAFEEESGKEEERQGVNKDDIHDTQEHGVLAQILAYGGNAQGGSNQANEADEADWTPRSKTGRPATRGRQGKGVQEDVVKTAAAKLHKPRGTARWKPDPIIERPFVCNICSAAFVRQQHLKRHERSVQRCQRTVQFEAYHRNVQRFFGVGPYVRTCMATRTKLRTYSFWIGKVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2023-06-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BWK5</accession>
    <name>A0A177BWK5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_424184</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441564">
        <property type="protein sequence ID" value="OAF98746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029112.1">
        <property type="nucleotide sequence ID" value="XM_018186172.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BWK5"/>
    <dbReference type="GeneID" id="28769658"/>
    <dbReference type="InParanoid" id="A0A177BWK5"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAF98746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="131" mass="14646" checksum="99CB44187E8FEC1F" modified="2016-09-07" version="1">MQWFLTISSCSGLAQIPHENEVNNHPAPQVIAEPTKTPMLNKIEAETCTATVIRSGLRTVLHGQCGICMLWGGHKKMRKAIRVRSPGRRGPRGPQGHKEHLEKAVAAEWLGTERHRQAQRHVDTRCASSVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BWN0</accession>
    <name>A0A177BWN0_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">dihydrolipoyllysine-residue succinyltransferase</fullName>
            <ecNumber evidence="5">2.3.1.61</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">2-oxoglutarate dehydrogenase complex component E2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CC84DRAFT_1169304</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid degradation; L-lysine degradation via saccharopine pathway; glutaryl-CoA from L-lysine: step 6/6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the 2-oxoacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.61" evidence="5"/>
    <dbReference type="EMBL" id="KV441561">
        <property type="protein sequence ID" value="OAF99812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030178.1">
        <property type="nucleotide sequence ID" value="XM_018179633.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BWN0"/>
    <dbReference type="FunCoup" id="A0A177BWN0">
        <property type="interactions" value="852"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177BWN0"/>
    <dbReference type="GeneID" id="28763119"/>
    <dbReference type="InParanoid" id="A0A177BWN0"/>
    <dbReference type="OrthoDB" id="5391403at2759"/>
    <dbReference type="UniPathway" id="UPA00868">
        <property type="reaction ID" value="UER00840"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045252">
        <property type="term" value="C:oxoglutarate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004149">
        <property type="term" value="F:dihydrolipoyllysine-residue succinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033512">
        <property type="term" value="P:L-lysine catabolic process to acetyl-CoA via saccharopine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06849">
        <property type="entry name" value="lipoyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.10:FF:000006">
        <property type="entry name" value="Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050537">
        <property type="entry name" value="2-oxoacid_dehydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001078">
        <property type="entry name" value="2-oxoacid_DH_actylTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006255">
        <property type="entry name" value="SucB"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004309">
        <property type="entry name" value="PRK05704.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01347">
        <property type="entry name" value="sucB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43416:SF5">
        <property type="entry name" value="DIHYDROLIPOYLLYSINE-RESIDUE SUCCINYLTRANSFERASE COMPONENT OF 2-OXOGLUTARATE DEHYDROGENASE COMPLEX, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43416">
        <property type="entry name" value="DIHYDROLIPOYLLYSINE-RESIDUE SUCCINYLTRANSFERASE COMPONENT OF 2-OXOGLUTARATE DEHYDROGENASE COMPLEX, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00198">
        <property type="entry name" value="2-oxoacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="6" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="14">
        <location>
            <begin position="79"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="155"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="165"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="181"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="191"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OAF99812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="474" mass="51857" checksum="848A6FB78BAC7D9D" modified="2016-09-07" version="1">MSGQQCLRRLAASSPLRPQPLLRASSKTIRLSASPATRSYSAVSRATSSGLLNKVSRRPARSSSQRVALFPQSRSYADTTVVKVPQMAESITEGTLKQWSKQVGDYVEQDEEIATIETDKIDVSVNAPEAGIIKEFLVNEEDTVEVGQDLVKLELGGAPSGGAKQEAKEEPKEPASKEQETSSQPQGQQEQPKEEKKPEPKKEESKPEPKQESKPAPPPQKPTPSKSSESEPKQAAPGAREERRVKMNRMRLRIAERLKQSQNTAASLTTFNEVDMSSIMEFRKLYKDEILKKQGVKLGFMSAFSRACILAMKEVPAVNASIEGPNGGDTIVYRDYVDISVAVATEKGLVTPVVRNAESLDMVGIEQAIADLGKKARDNKLTIEDMAGGTFTISNGGVFGSLMGTPIINLPQTAVLGLHAIKDKPVAINGKVEIRPMMYLALTYDHRLLDGREAVTFLVKIKEFIEDPRKMLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BX80</accession>
    <name>A0A177BX80_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RNA-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CC84DRAFT_1169711</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441563">
        <property type="protein sequence ID" value="OAF98986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029352.1">
        <property type="nucleotide sequence ID" value="XM_018179733.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BX80"/>
    <dbReference type="STRING" id="1460663.A0A177BX80"/>
    <dbReference type="GeneID" id="28763219"/>
    <dbReference type="InParanoid" id="A0A177BX80"/>
    <dbReference type="OrthoDB" id="439808at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052462">
        <property type="entry name" value="SLIRP/GR-RBP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48027">
        <property type="entry name" value="HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN 87F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="17"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="50"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="52"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="66"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAF98986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="148" mass="14324" checksum="994A809B11F20D66" modified="2016-09-07" version="1">MKIGNFHWHGTDSVQVVVKDRDTGRSRGFGFVRFSQESEADNAMQNMNNVEFDGRTIRVDKASDRSGGGGGGGRGGYGGGRGGGGYGGGGGSYGGGGGYGGGGGASWGQGGGGGGYQPRGGYGGGQGGQGGYGGGQEGGQNGGGGQQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BX94</accession>
    <name>A0A177BX94_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">LysR family regulatory protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1130719</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441561">
        <property type="protein sequence ID" value="OAF99755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030121.1">
        <property type="nucleotide sequence ID" value="XM_018175869.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BX94"/>
    <dbReference type="STRING" id="1460663.A0A177BX94"/>
    <dbReference type="GeneID" id="28759355"/>
    <dbReference type="InParanoid" id="A0A177BX94"/>
    <dbReference type="OrthoDB" id="21502at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAF99755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="529" mass="59621" checksum="9C251B748B4E8E65" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2023-06-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BXA5</accession>
    <name>A0A177BXA5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_414371</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441563">
        <property type="protein sequence ID" value="OAF99016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029382.1">
        <property type="nucleotide sequence ID" value="XM_018186111.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BXA5"/>
    <dbReference type="GeneID" id="28769597"/>
    <dbReference type="InParanoid" id="A0A177BXA5"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAF99016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="123" mass="13165" checksum="429CC11E66902D57" modified="2016-09-07" version="1">MCAFRIVEKSPCTSVIGMALLGRASKPATTLRCRAVPRMNTVLPTSSALIFHIAGLLAVYCRRGSDSVSDSVGSAFSSRSPHPTDEHARLVLSRMCNALSTSFMSRALANDLRITNLAAIALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BXQ7</accession>
    <name>A0A177BXQ7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Protein transport protein Sec61 subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CC84DRAFT_1222990</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SEC61-beta family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441562">
        <property type="protein sequence ID" value="OAF99297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029663.1">
        <property type="nucleotide sequence ID" value="XM_018183450.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BXQ7"/>
    <dbReference type="STRING" id="1460663.A0A177BXQ7"/>
    <dbReference type="GeneID" id="28766936"/>
    <dbReference type="InParanoid" id="A0A177BXQ7"/>
    <dbReference type="OrthoDB" id="5401193at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005784">
        <property type="term" value="C:Sec61 translocon complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030671">
        <property type="entry name" value="Sec61-beta/Sbh"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016482">
        <property type="entry name" value="SecG/Sec61-beta/Sbh"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13509">
        <property type="entry name" value="SEC61 SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03911">
        <property type="entry name" value="Sec61_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="484"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="62"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="207"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="20"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="118"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="153"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="169"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="207"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="272"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="295"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="325"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="352"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="393"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="440"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OAF99297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="512" mass="54354" checksum="CC49A150AA5F1741" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2023-06-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BY16</accession>
    <name>A0A177BY16_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1230422</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441559">
        <property type="protein sequence ID" value="OAG00414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030779.1">
        <property type="nucleotide sequence ID" value="XM_018183694.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BY16"/>
    <dbReference type="GeneID" id="28767180"/>
    <dbReference type="InParanoid" id="A0A177BY16"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008057457" evidence="1">
        <location>
            <begin position="19"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG00414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="291" mass="32337" checksum="D09F8B6EDD9C4973" modified="2016-09-07" version="1">MSLFGLFVLLLQLTLPSATPLIAEGPQGSCCPCILYPWRGRDPQENSDLACQTCVLDLLRTPQDLRPNHNNEYHDYNSKMHRDEYSQDYGHDHIWSRNLVGHNHHNVIRNNHLHITLDCNYHSNCTGHLISDIAYYLCDNNACWHNYSIYSTNGLLQIHWAMLRLVVRPNFDQSSSTLRAKGCSCYVTSQPASTQVVTATTKTSSTKTSTTTVSTIFVPFRTTTVTLTVVIGAMSTTTTTSITTATEQSFSTVYETVTSTTTSTATGPTVTATVTVPVGYTQTHRKDLVFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BY48</accession>
    <name>A0A177BY48_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1169456</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441562">
        <property type="protein sequence ID" value="OAF99326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029692.1">
        <property type="nucleotide sequence ID" value="XM_018179663.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BY48"/>
    <dbReference type="GeneID" id="28763149"/>
    <dbReference type="InParanoid" id="A0A177BY48"/>
    <dbReference type="OrthoDB" id="3788831at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAF99326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="196" mass="22844" checksum="F59679E3A895AEFA" modified="2016-09-07" version="1">MPNLQSPSNPTSYRRTGWQIALMLLMGINYLMDHDPRHVQYSKDQRAKRKAEKQRYKAGFVVELPDDEDMNGERVDPNATREDLRPHSPCCHPPPVSQNGKEAWPCPRGASHRNPRPNRSYAKAPSRHVPKPADRSQMRDAWTRMRAVTKALYEFVKRVDRRKKRVRFKKDVQCFVLDGDEDEHGGDYGENMYGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BYB2</accession>
    <name>A0A177BYB2_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1210265</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441562">
        <property type="protein sequence ID" value="OAF99396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029762.1">
        <property type="nucleotide sequence ID" value="XM_018182280.1"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177BYB2"/>
    <dbReference type="GeneID" id="28765766"/>
    <dbReference type="InParanoid" id="A0A177BYB2"/>
    <dbReference type="OrthoDB" id="3944206at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24216:SF65">
        <property type="entry name" value="PAXILLIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24216">
        <property type="entry name" value="PAXILLIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="483"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="670"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="830"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1191"/>
            <end position="1227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1246"/>
            <end position="1313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1339"/>
            <end position="1690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="670"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="873"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1251"/>
            <end position="1273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1351"/>
            <end position="1363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1364"/>
            <end position="1374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1383"/>
            <end position="1406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1459"/>
            <end position="1468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1475"/>
            <end position="1484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1489"/>
            <end position="1528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1584"/>
            <end position="1596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1628"/>
            <end position="1639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1647"/>
            <end position="1664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1665"/>
            <end position="1676"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAF99396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1740" mass="195725" checksum="B5103B1EA5D15B74" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BYG5</accession>
    <name>A0A177BYG5_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Gfd2/YDR514C-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1103243</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441560">
        <property type="protein sequence ID" value="OAG00001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030366.1">
        <property type="nucleotide sequence ID" value="XM_018175005.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BYG5"/>
    <dbReference type="GeneID" id="28758491"/>
    <dbReference type="InParanoid" id="A0A177BYG5"/>
    <dbReference type="OrthoDB" id="3758270at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040151">
        <property type="entry name" value="Gfd2/YDR514C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048519">
        <property type="entry name" value="Gfd2/YDR514C-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28083">
        <property type="entry name" value="GOOD FOR FULL DBP5 ACTIVITY PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28083:SF1">
        <property type="entry name" value="GOOD FOR FULL DBP5 ACTIVITY PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21762">
        <property type="entry name" value="DEDDh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfd2/YDR514C-like C-terminal" evidence="1">
        <location>
            <begin position="6"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF21762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG00001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="222" mass="25208" checksum="C587E31CC250E51D" modified="2016-09-07" version="1" fragment="single">GAHAEDYLLHVWSAHLRLLENTHVPSITSDPNAYHFGTSVYASKEEVVNFLHDIWHQPLDEENPELGYRPIICLQHGNPLGHRATWKELGFDPMKMDTTIAMLDNQVIAQQSKLTRNSYAEIDYLLSQFKIQPRDSTNCGNAAVYITISSVLCALRQHLYQSLRNPKSKPGQYGQSASKTAQAVVNEWMERPTPAPPVGNEAYCLRCKSHEHLFTECPLYFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BYM6</accession>
    <name>A0A177BYM6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Endo-1,3-1,4-beta-D-glucanase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1221981</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441559">
        <property type="protein sequence ID" value="OAG00473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030838.1">
        <property type="nucleotide sequence ID" value="XM_018183317.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BYM6"/>
    <dbReference type="STRING" id="1460663.A0A177BYM6"/>
    <dbReference type="GeneID" id="28766803"/>
    <dbReference type="InParanoid" id="A0A177BYM6"/>
    <dbReference type="OrthoDB" id="10019231at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17630">
        <property type="entry name" value="DIENELACTONE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17630:SF55">
        <property type="entry name" value="DIENELACTONE HYDROLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_1G01900)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
        <property type="entry name" value="DLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dienelactone hydrolase" evidence="1">
        <location>
            <begin position="28"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG00473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="248" mass="27917" checksum="DCC0B926559EDAB7" modified="2016-09-07" version="1">MVTECCISGFQWDGTPIGSEGRIADNNAYIVGDSNKVAILVIADLFGWSFTNTRLLCDAYAAETPATVYMPDFFGGQVIDPAIIANTNRWNEFDLEEWSKQNAKDVRWLEILGVARALRAKYDKVGVIGYCYGGWSLFRLGDKNLNGLVDCISTAHPTWLTRDEIDTIGVPVQICAPEIDAAFTPELKAYANEVIPTKGVPYDYQYFHGVEHAFATRGNLEDERERRAMVRAKRAMVAWMREWLRGED</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BYN9</accession>
    <name>A0A177BYN9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1221797</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441559">
        <property type="protein sequence ID" value="OAG00266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030631.1">
        <property type="nucleotide sequence ID" value="XM_018183304.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BYN9"/>
    <dbReference type="GeneID" id="28766790"/>
    <dbReference type="InParanoid" id="A0A177BYN9"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="243"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG00266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="265" mass="28298" checksum="6ED068634935BC66" modified="2016-09-07" version="1">MTSEQNMGMRTSSTFCTCIAEGVAKHRSAPRMQAQLPGQSRCASPRMLVPCRARRASGFLSRSLRTVADTDATLVAVSIPGSLPNDGFTIVQRRPPGTGVLETSSWVRQPLWLVAARPAQCCVLLLARRAPRSPETRARSQRTQGTPITAPSPPRRCTHWQLARAPSSEPLSLPRVAASACAIGLPNPAPSREALRLGLSARVLGASEHAAALHMSYGAPQTSTPHAPALLSFHLARTGLLPCHDPSRLPSTMPAEQQPDRPPAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BYZ6</accession>
    <name>A0A177BYZ6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Actin-like ATPase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1168830</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the actin family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441560">
        <property type="protein sequence ID" value="OAF99918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030284.1">
        <property type="nucleotide sequence ID" value="XM_018179493.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BYZ6"/>
    <dbReference type="STRING" id="1460663.A0A177BYZ6"/>
    <dbReference type="GeneID" id="28762979"/>
    <dbReference type="InParanoid" id="A0A177BYZ6"/>
    <dbReference type="OrthoDB" id="337660at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="80"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="439"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="89"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="439"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAF99918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="566" mass="62509" checksum="C6B318FA155A2E9B" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BZ47</accession>
    <name>A0A177BZ47_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">General amino-acid permease-like protein GAP1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CC84DRAFT_1129468</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441559">
        <property type="protein sequence ID" value="OAG00653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031018.1">
        <property type="nucleotide sequence ID" value="XM_018175834.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BZ47"/>
    <dbReference type="FunCoup" id="A0A177BZ47">
        <property type="interactions" value="215"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177BZ47"/>
    <dbReference type="GeneID" id="28759320"/>
    <dbReference type="InParanoid" id="A0A177BZ47"/>
    <dbReference type="OrthoDB" id="3900342at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000017">
        <property type="entry name" value="Amino acid permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004762">
        <property type="entry name" value="Amino_acid_permease_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00913">
        <property type="entry name" value="2A0310"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF1">
        <property type="entry name" value="GENERAL AMINO-ACID PERMEASE GAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="118"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="166"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="199"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="228"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="311"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="368"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="414"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="444"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="488"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="529"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="10">
        <location>
            <begin position="87"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="19"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OAG00653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="595" mass="64937" checksum="2EB549A0D866EA12" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BZW7</accession>
    <name>A0A177BZW7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">WW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1221338</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441558">
        <property type="protein sequence ID" value="OAG00765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031130.1">
        <property type="nucleotide sequence ID" value="XM_018183263.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BZW7"/>
    <dbReference type="STRING" id="1460663.A0A177BZW7"/>
    <dbReference type="GeneID" id="28766749"/>
    <dbReference type="InParanoid" id="A0A177BZW7"/>
    <dbReference type="OrthoDB" id="3801354at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WW" evidence="2">
        <location>
            <begin position="117"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="270"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="43"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="270"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="282"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="310"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="324"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG00765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="339" mass="35966" checksum="055BF8DE44C76CBD" modified="2016-09-07" version="1">MDFLKKKMKELMDDDDKPKEKSSDKPSESHGDSTGHDTRAADPHAGGYPPQQHQQYPQQGYPPQQGGYPQQHPQQGGYPPQQGGYPQQGYPQQQPYGQQGYGSPAPQGPPAPYGAPPPMPPGWVAQFDQNSQKWYYIDQATGRSQWEPPAHAPPAQGPYAPPPSGPPGAPYGSGAHDERALFGASHDQSHGGYPSGHGDPYAPGGGHGDPYGEKGKDKDKKKDKGHSTAMLAAAGVGGIAAGAWIGHELTENSDDETKVVQNNYYGAAPAAAAAPVAAAPVAAPPAEPPAFQEPPPVPTHDADGDSISSSDRESLEEKRQELIEAQEEYAEELEEAYDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C059</accession>
    <name>A0A177C059_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1199247</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441559">
        <property type="protein sequence ID" value="OAG00279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030644.1">
        <property type="nucleotide sequence ID" value="XM_018181610.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C059"/>
    <dbReference type="STRING" id="1460663.A0A177C059"/>
    <dbReference type="GeneID" id="28765096"/>
    <dbReference type="InParanoid" id="A0A177C059"/>
    <dbReference type="OrthoDB" id="3650366at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053226">
        <property type="entry name" value="Pyrrolopyrazine_biosynth_F"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48419">
        <property type="entry name" value="SULFOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48419:SF1">
        <property type="entry name" value="SULFOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG00279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="319" mass="36167" checksum="1B987282E3058B83" modified="2016-09-07" version="1">MATAQSCSAPLGHHMVFTIPRTASHLLLKLLNLPQQHSVYRHSNNQDGYMFLPAAALRFRQSLPGKAIQEWSEEEKTALKDAMQGSFDDWLGLIEEAEKQGKSTFVKEHLNWMASPAAEARLYGHQKSNSSTTTQFQVHWKTQQISDSRKQDNITYLPDAFLLQEVKPTFLIRHPALTFPSCLRTAMDNEGASSVIDGEKIQQWECTYFWSLSLYTFYIESAAEFDRRSFVDGVKYPIVLDAQDLGDEALVRKYAKAVGLDEEKVRFTWKAAEETELARLGKVEKRMKSTILASSGIEEGKLNAALDIEIQRLTKRSKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C0I8</accession>
    <name>A0A177C0I8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1209377</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441559">
        <property type="protein sequence ID" value="OAG00409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030774.1">
        <property type="nucleotide sequence ID" value="XM_018182217.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C0I8"/>
    <dbReference type="STRING" id="1460663.A0A177C0I8"/>
    <dbReference type="GeneID" id="28765703"/>
    <dbReference type="InParanoid" id="A0A177C0I8"/>
    <dbReference type="OrthoDB" id="5309154at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="240"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="396"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="438"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="242"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="319"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG00409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="524" mass="59104" checksum="0351F0C224B7B755" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C0P8</accession>
    <name>A0A177C0P8_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CC84DRAFT_1263222</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441558">
        <property type="protein sequence ID" value="OAG01213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031578.1">
        <property type="nucleotide sequence ID" value="XM_018185218.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C0P8"/>
    <dbReference type="STRING" id="1460663.A0A177C0P8"/>
    <dbReference type="GeneID" id="28768704"/>
    <dbReference type="InParanoid" id="A0A177C0P8"/>
    <dbReference type="OrthoDB" id="2496787at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF47">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="67"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="110"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="146"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="195"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="227"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="259"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="9">
        <location>
            <begin position="51"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="296"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="382"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="441"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="313"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAG01213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="477" mass="53293" checksum="EB6EBA2DDA50FA21" modified="2016-09-07" version="1">MLFSSGIASNLKVALLHVQADLCDKPHDNKSLSIKITAWTTGIISIVAVILRFVSRHLGGSPLWWDDWLQLASIILVIPMTVSLLLNAEAGIGHHIWDLTYHQVKTIGQWTYITTICWALELLILKFSILCLYVRIFPNPWLKRAVMIFTVFTILYTGPLVFLAALQCIPVHAIWDLEAQKTAKCIDWIAVLRATVVFEVIAEVLIFVLPIPVVLRLKLRRSKKIQLLTFFGLGVCIIGISVARLPTLPGVVSSEDQPYTTVGATILGFVASVVGHVCAAVPTIRALVRLWCGSLDDSSSRSRPSRFGKGWGSSTASSGKRSSWFSRSQSYHSSNLLPSQNTDKEKSAGITVQQHFGVQPLLETREDVVLLDLQPIRERAYQPARPQRGVGQWNSGRPRWVTDEEQPPSIIREPWKEADIDDSSSEKDVLPNQGFARTSSVRAIEEHIHSMEARMLELETEIQFYRSNSVRGQASRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C298</accession>
    <name>A0A177C298_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1261975</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441556">
        <property type="protein sequence ID" value="OAG01914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032279.1">
        <property type="nucleotide sequence ID" value="XM_018185113.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C298"/>
    <dbReference type="GeneID" id="28768599"/>
    <dbReference type="InParanoid" id="A0A177C298"/>
    <dbReference type="OrthoDB" id="270167at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF64">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="80"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG01914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="466" mass="53139" checksum="76456A5AAF659DA7" modified="2016-09-07" version="1">MEHDTSKTFREIHGTPSALVAELDRIQGLALRRSRRLHRVEIPVQLRFLAPLDPQPQGYGPDTVHLRLTSPQEYTETQEYVAVSYTWQQPQSFTDAFLNRIPTYKIWDTDSQPYNPECNPLVIHRAYRFAQKKLKQVLIWIDQECIRQDDPDDVETHVLAMHEIYRHSAFTVVLLSRMVDSVPMAAGLYPFMHGGADVFDKLLKSDDCRVRKLCLVALQLLAQDRWFSRTWTYQERFFATVCYYAVSIEPTLGANTQDGGLEDWYIPERNIVAFSKKTADNATALNKDHFGFDFRPSAKGMCACTMVTFSLVRLIKFKFEASRSVNWKIHLPGFESFGIKSAGISTPREVMSRTAKVSAAEDELDRIQGRFETINHVFLDMEACDNAIVADRVSIFANVCQLGWTLPTVKLREENLSYSTCILALLLLDVLKVPGEAAKMELAESAMRLSIGGFIRNEGYPFSKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C3W3</accession>
    <name>A0A177C3W3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Tat pathway signal sequence</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1189874</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Mycotoxin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ustYa family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441557">
        <property type="protein sequence ID" value="OAG01589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031954.1">
        <property type="nucleotide sequence ID" value="XM_018181080.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C3W3"/>
    <dbReference type="GeneID" id="28764566"/>
    <dbReference type="InParanoid" id="A0A177C3W3"/>
    <dbReference type="OrthoDB" id="3687641at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021765">
        <property type="entry name" value="UstYa-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365:SF4">
        <property type="entry name" value="CYCLOCHLOROTINE BIOSYNTHESIS PROTEIN O"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365">
        <property type="entry name" value="YALI0B05434P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11807">
        <property type="entry name" value="UstYa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00035112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG01589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="196" mass="23088" checksum="8E43CA1184591B88" modified="2016-09-07" version="1">MTETSKDYGLVGQPSEELDRKWSSIMQYFYAEIPKEYMEKLGRTQEGIRLPNGNYLANYAFIHQLHCLKRLYQSYFPDYYWPDMTEEETELQHEHSLHCLQMLVEQVMCKADETPLTMYWFNESILPGGNRTIAHECVNWDRLLEGMEKNKVDPFTPGLLVHPKFGPVLPNGRQTQLDNRIGYVKHATPLDRTQWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C415</accession>
    <name>A0A177C415_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Multiple myeloma tumor-associated protein 2-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1051686</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441557">
        <property type="protein sequence ID" value="OAG01639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032004.1">
        <property type="nucleotide sequence ID" value="XM_018173488.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C415"/>
    <dbReference type="GeneID" id="28756974"/>
    <dbReference type="InParanoid" id="A0A177C415"/>
    <dbReference type="OrthoDB" id="5390672at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019315">
        <property type="entry name" value="MMTA2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039207">
        <property type="entry name" value="MMTAG2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14580:SF0">
        <property type="entry name" value="MULTIPLE MYELOMA TUMOR-ASSOCIATED PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14580">
        <property type="entry name" value="MULTIPLE MYELOMA TUMOR-ASSOCIATED PROTEIN 2 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10159">
        <property type="entry name" value="MMtag"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Multiple myeloma tumor-associated protein 2-like N-terminal" evidence="2">
        <location>
            <begin position="11"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG01639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="183" mass="21610" checksum="5480251216ABEA6A" modified="2016-09-07" version="1" fragment="single">MDLLQTVRKEGSRGGRADFKWEDVKADAQRENYLGHSLMAPVGRWQQGRDLNWYAKGDQDKEGEMSAAEKLAEEKRKIKEAEEDAMLRAMGLPVPERASTNANLTPLGEKAHEADVEKALEEKTKDSDEGDKTKERKERSRRHRDDDEPDRKRRHRSRSRSRDRKEKRRDRSRSRDRRRDRDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C4V6</accession>
    <name>A0A177C4V6_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_1261980</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441556">
        <property type="protein sequence ID" value="OAG01919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032284.1">
        <property type="nucleotide sequence ID" value="XM_018185115.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C4V6"/>
    <dbReference type="STRING" id="1460663.A0A177C4V6"/>
    <dbReference type="GeneID" id="28768601"/>
    <dbReference type="InParanoid" id="A0A177C4V6"/>
    <dbReference type="OrthoDB" id="2593732at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052360">
        <property type="entry name" value="Transcr_Regulatory_Proteins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206">
        <property type="entry name" value="ASPERCRYPTIN BIOSYNTHESIS CLUSTER-SPECIFIC TRANSCRIPTION REGULATOR ATNN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206:SF12">
        <property type="entry name" value="ASPERCRYPTIN BIOSYNTHESIS CLUSTER-SPECIFIC TRANSCRIPTION REGULATOR ATNN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="18"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAG01919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="525" mass="59969" checksum="31300F77C6464E00" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C5C0</accession>
    <name>A0A177C5C0_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ABM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1058418</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG02813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033178.1">
        <property type="nucleotide sequence ID" value="XM_018173563.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C5C0"/>
    <dbReference type="STRING" id="1460663.A0A177C5C0"/>
    <dbReference type="GeneID" id="28757049"/>
    <dbReference type="InParanoid" id="A0A177C5C0"/>
    <dbReference type="OrthoDB" id="194076at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38052:SF1">
        <property type="entry name" value="ABM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38052">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG02813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="100" mass="12023" checksum="AB8627D62830D889" modified="2016-09-07" version="1" fragment="single">MVYTIVVHLYAKEDEESIEKLKAKLVEASQVYSKDKETLSWFVMQDVADKRKFTIVERYLKESSQKYHLENPYWKTFDPYVNPLLDKPMDLRRLEELDTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C5U3</accession>
    <name>A0A177C5U3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CC84DRAFT_939296</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG02993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033358.1">
        <property type="nucleotide sequence ID" value="XM_018187930.1"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177C5U3"/>
    <dbReference type="GeneID" id="28771416"/>
    <dbReference type="InParanoid" id="A0A177C5U3"/>
    <dbReference type="OrthoDB" id="5403573at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000127">
        <property type="term" value="C:transcription factor TFIIIC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042791">
        <property type="term" value="P:5S class rRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006384">
        <property type="term" value="P:transcription initiation at RNA polymerase III promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046488">
        <property type="entry name" value="Sfc3/Tfc3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044210">
        <property type="entry name" value="Tfc3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007309">
        <property type="entry name" value="TFIIIC_Bblock-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15180">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15180:SF1">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04182">
        <property type="entry name" value="B-block_TFIIIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20222">
        <property type="entry name" value="DUF6581"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="B-block binding subunit of TFIIIC" evidence="7">
        <location>
            <begin position="227"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="Transcription factor tau subunit sfc3/Tfc3 C-terminal" evidence="8">
        <location>
            <begin position="1777"/>
            <end position="2204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="92"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="145"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="412"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="631"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="694"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="816"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="931"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1041"/>
            <end position="1062"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1112"/>
            <end position="1168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1200"/>
            <end position="1225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1238"/>
            <end position="1308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1476"/>
            <end position="1582"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1636"/>
            <end position="1725"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="2327"/>
            <end position="2403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="94"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="146"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="833"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="850"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1048"/>
            <end position="1062"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1112"/>
            <end position="1124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1134"/>
            <end position="1143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1200"/>
            <end position="1224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1238"/>
            <end position="1270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1299"/>
            <end position="1308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1482"/>
            <end position="1512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1554"/>
            <end position="1567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1671"/>
            <end position="1695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="1696"/>
            <end position="1709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="2362"/>
            <end position="2375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="2379"/>
            <end position="2403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAG02993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="2403" mass="268535" checksum="9172620DA2634BAD" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C654</accession>
    <name>A0A177C654_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1004842</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441556">
        <property type="protein sequence ID" value="OAG02170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032535.1">
        <property type="nucleotide sequence ID" value="XM_018173336.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C654"/>
    <dbReference type="GeneID" id="28756822"/>
    <dbReference type="InParanoid" id="A0A177C654"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="166"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG02170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="179" mass="20185" checksum="38EB4916AB3290DE" modified="2016-09-07" version="1">MVKSLKSHTSSLDTLSWRDGIHSQDIHYMGPLGFLSGFVKLSHVEAPLAVLAQQTHDINITVESIVANLPRSVQVLTMNVIHDGIAYYQKCLDYMAWNFGDYLPSLRQVKVIYHSLLTPPVYEWEKLGKLLTDRGILFEFIHSISEEEADGEGNWAPYVTRDDSASSDSSGYEESLYSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C695</accession>
    <name>A0A177C695_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1166898</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG03153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033518.1">
        <property type="nucleotide sequence ID" value="XM_018179076.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C695"/>
    <dbReference type="STRING" id="1460663.A0A177C695"/>
    <dbReference type="GeneID" id="28762562"/>
    <dbReference type="InParanoid" id="A0A177C695"/>
    <dbReference type="OrthoDB" id="74545at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01709">
        <property type="entry name" value="RT_like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37015">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37015:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="771"/>
            <end position="798"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG03153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="899" mass="103196" checksum="1F9D1BC48BE76338" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C6Q3</accession>
    <name>A0A177C6Q3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">Autophagy-related protein 17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CC84DRAFT_1099255</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Autophagy-specific protein that functions in response to autophagy-inducing signals as a scaffold to recruit other ATG proteins to organize preautophagosomal structure (PAS) formation. Modulates the timing and magnitude of the autophagy response, such as the size of the sequestering vesicles. Plays particularly a role in pexophagy and nucleophagy.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Preautophagosomal structure membrane</location>
            <topology evidence="6">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the ATG17 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441556">
        <property type="protein sequence ID" value="OAG02458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032823.1">
        <property type="nucleotide sequence ID" value="XM_018174814.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C6Q3"/>
    <dbReference type="FunCoup" id="A0A177C6Q3">
        <property type="interactions" value="137"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177C6Q3"/>
    <dbReference type="GeneID" id="28758300"/>
    <dbReference type="InParanoid" id="A0A177C6Q3"/>
    <dbReference type="OrthoDB" id="1937984at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990316">
        <property type="term" value="C:Atg1/ULK1 kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030295">
        <property type="term" value="F:protein kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007240">
        <property type="entry name" value="Atg17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045326">
        <property type="entry name" value="ATG17-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28005">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28005:SF1">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04108">
        <property type="entry name" value="ATG17_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0072">Autophagy</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Autophagy protein ATG17-like" evidence="9">
        <location>
            <begin position="41"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="255"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="390"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="15"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU368080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAG02458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="496" mass="55566" checksum="FB2C2BA7A8FDA445" modified="2016-09-07" version="1">MASPPSPASSTTSANSQRSLHPNRPQTLEDLVTHFVASKRSLQTQTILWRANDIVTSARELLEENAVLAAKNTSIRNMVEEQVDALEAVRRGIDVVEGDVQAEFKQLLHDLDTSFAGLKSTLAVLRETPIESALQPSGTPQKHLYDFIDNTTVSALEDSLRACIDRYNDVHSTLEESTDAFDTSLENLQSSIINVPKTPVTNSIPSPIPSLYHDLEGHAREAAQAFQSLVKHYDLCVTALRHTEGGAAAVTQATGDASLPSADDHGPPPEPISEEERQEMLSVLERDAQEVEDVVTEIREHGSEMSYLLSQIDNHITHLRNEDSALGSVLKMIANIAREVKGHIATSRAFHTSWLDDTRPTLLNGIEEWENQRDFYERFDLAYAELLVEIASRRRRHDKAKRKAEEAQKELDRLHAEDERAREQFTLAQGDFLPLDIWPGLRDPPRRYEVRAVAVPHEQDMEEGEEANDADLVAKSIPQLGRNVVERALVRVKRRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C6S3</accession>
    <name>A0A177C6S3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1262393</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441556">
        <property type="protein sequence ID" value="OAG02478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032843.1">
        <property type="nucleotide sequence ID" value="XM_018185150.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C6S3"/>
    <dbReference type="GeneID" id="28768636"/>
    <dbReference type="InParanoid" id="A0A177C6S3"/>
    <dbReference type="OrthoDB" id="10478278at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG02478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="190" mass="21252" checksum="50F2920CB70CBFF2" modified="2016-09-07" version="1">MSSPSCLGPPFSSIPTIYTAEALAHAAVISPVDRLRTSIASYSFWIADNANFINLVAQTTRHSPLSRQVIPPTTAAMFCSAISGFFDRLDTYWTGKRTHKAASRQEAHDREAREQQWTEGHRQGPPSAVQHPGASKDYSDDMENQARPLRAEPQATRKKTVRRQILQPGQRSLETLEIGRIGTAEKFYRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C759</accession>
    <name>A0A177C759_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ankyrin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1220238</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG03375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033740.1">
        <property type="nucleotide sequence ID" value="XM_018183149.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C759"/>
    <dbReference type="GeneID" id="28766635"/>
    <dbReference type="InParanoid" id="A0A177C759"/>
    <dbReference type="OrthoDB" id="3918771at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13857">
        <property type="entry name" value="Ank_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG03375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="265" mass="29487" checksum="FCC4C3D116FE70D0" modified="2016-09-07" version="1">MGGFSQDSPKSGMELSILGSLLYHAKRHPYHILAVKTFLELVGARDSLFNNVMRQGPNNYTMNALQFTILYTMDAATISTGTELLAVLLQTFNHPRNHLACQDGPRRLSLLHLAVKHGNYAALDILLAEPGMNADMRNVKNLTALDLCLTRWQDSIRDGSDDYRLALKAGISEAAARAGWEATTEGLIECMERRGASRYGNIKTVFKRLSHFEMMWIRISGEGRIQRDGFDPTGIQSDVFSSAEKNDTARAIANLEVGDCLFFSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C7P4</accession>
    <name>A0A177C7P4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">GroES-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CC84DRAFT_1220048</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG03151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033516.1">
        <property type="nucleotide sequence ID" value="XM_018183133.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C7P4"/>
    <dbReference type="STRING" id="1460663.A0A177C7P4"/>
    <dbReference type="GeneID" id="28766619"/>
    <dbReference type="InParanoid" id="A0A177C7P4"/>
    <dbReference type="OrthoDB" id="3509362at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08249">
        <property type="entry name" value="enoyl_reductase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047122">
        <property type="entry name" value="Trans-enoyl_RdTase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348">
        <property type="entry name" value="HYPOTHETICAL OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348:SF2">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE PROTEIN C2E1P3.01"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="4">
        <location>
            <begin position="14"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAG03151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="348" mass="37347" checksum="72C2E3A0D486404F" modified="2016-09-07" version="1">MSGNRAAFLVEPKGCFEVRDAPMEQPGPGEVLIKVHAVALQPADEKVAKLAIILVEYPAVLGGPVGGIVHALGEGVTRVAVGDRVSCGTLIFKKHKPKYGGTQRYTLVSEQEVIEIGDTDFTKVVTLGSYTPPSCLFASNCLNMHWPSLPPKPLPAGEQGKKILIWGGSSAMGSLSISYAKQAGYTVISTSSPHNFDLLESLGADYIFDHSDLATVERIRDLFPIDYWFDTISLKPSVTTILKILAPEGKPANKAYIHMLLPLAMAGNPTLPEGVTTGMHFFSTQAPENADWAKFFLSRGGYMEKGIKSGLIQGVPPHLLGGLEKVSDGIEEVHKGVSGKKVVIDPWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C7Y5</accession>
    <name>A0A177C7Y5_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein BNI4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1219115</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG03854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034219.1">
        <property type="nucleotide sequence ID" value="XM_018183056.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C7Y5"/>
    <dbReference type="STRING" id="1460663.A0A177C7Y5"/>
    <dbReference type="GeneID" id="28766542"/>
    <dbReference type="InParanoid" id="A0A177C7Y5"/>
    <dbReference type="OrthoDB" id="5563016at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12751:SF18">
        <property type="entry name" value="PHOSPHATASE AND ACTIN REGULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12751">
        <property type="entry name" value="PHOSPHATASE AND ACTIN REGULATOR PHACTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="279"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="533"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="37"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="73"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="180"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="286"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="328"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="354"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="563"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="621"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="645"/>
            <end position="663"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG03854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="723" mass="76888" checksum="6524A77B5DD771A5" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C802</accession>
    <name>A0A177C802_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Thioredoxin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1165883</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG03685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034050.1">
        <property type="nucleotide sequence ID" value="XM_018178817.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C802"/>
    <dbReference type="STRING" id="1460663.A0A177C802"/>
    <dbReference type="GeneID" id="28762303"/>
    <dbReference type="InParanoid" id="A0A177C802"/>
    <dbReference type="OrthoDB" id="10263751at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02947">
        <property type="entry name" value="TRX_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050620">
        <property type="entry name" value="Thioredoxin_H-type-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10438">
        <property type="entry name" value="THIOREDOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10438:SF468">
        <property type="entry name" value="THIOREDOXIN-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="1">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG03685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="107" mass="11791" checksum="CCE1D4C567CFCC10" modified="2016-09-07" version="1">MSVSTIPKLESKAAYLKAVMYEGVTVLEGTATWCAQCKAIAPEVQKIVSEYPDVHFYTYDVEETEDIAQELGVSQMPTFSIFKDGDIQEGVTGAKPKELRKAIEANL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C8E5</accession>
    <name>A0A177C8E5_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Arrestin C-terminal-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1151495</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG03132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033497.1">
        <property type="nucleotide sequence ID" value="XM_018176750.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C8E5"/>
    <dbReference type="FunCoup" id="A0A177C8E5">
        <property type="interactions" value="68"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177C8E5"/>
    <dbReference type="GeneID" id="28760236"/>
    <dbReference type="InParanoid" id="A0A177C8E5"/>
    <dbReference type="OrthoDB" id="2238745at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070086">
        <property type="term" value="P:ubiquitin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011021">
        <property type="entry name" value="Arrestin-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011022">
        <property type="entry name" value="Arrestin_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050357">
        <property type="entry name" value="Arrestin_domain-protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188">
        <property type="entry name" value="ARRESTIN DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188:SF174">
        <property type="entry name" value="ARRESTIN-RELATED TRAFFICKING ADAPTER 10-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02752">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00339">
        <property type="entry name" value="Arrestin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01017">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arrestin C-terminal-like" evidence="2">
        <location>
            <begin position="425"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="292"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="326"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="669"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="292"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="728"/>
            <end position="737"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG03132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="802" mass="87879" checksum="505F07A7DDD768FC" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C8J7</accession>
    <name>A0A177C8J7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">TPR-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CC84DRAFT_1166799</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the APC3/CDC27 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG03030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033395.1">
        <property type="nucleotide sequence ID" value="XM_018179051.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C8J7"/>
    <dbReference type="FunCoup" id="A0A177C8J7">
        <property type="interactions" value="843"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177C8J7"/>
    <dbReference type="GeneID" id="28762537"/>
    <dbReference type="InParanoid" id="A0A177C8J7"/>
    <dbReference type="OrthoDB" id="329563at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007091">
        <property type="term" value="P:metaphase/anaphase transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013105">
        <property type="entry name" value="TPR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558">
        <property type="entry name" value="CELL DIVISION CYCLE 16,23,27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558:SF13">
        <property type="entry name" value="CELL DIVISION CYCLE PROTEIN 27 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12895">
        <property type="entry name" value="ANAPC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00515">
        <property type="entry name" value="TPR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07719">
        <property type="entry name" value="TPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="126"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="595"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="663"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="697"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="765"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="192"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="456"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="192"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="245"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="349"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="367"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAG03030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="821" mass="91942" checksum="704CF5817D8BDC48" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C8P9</accession>
    <name>A0A177C8P9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Centromere protein X</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_1166149</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CENP-X/MHF2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG04013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034378.1">
        <property type="nucleotide sequence ID" value="XM_018178887.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C8P9"/>
    <dbReference type="STRING" id="1460663.A0A177C8P9"/>
    <dbReference type="GeneID" id="28762373"/>
    <dbReference type="InParanoid" id="A0A177C8P9"/>
    <dbReference type="OrthoDB" id="2500381at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071821">
        <property type="term" value="C:FANCM-MHF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051382">
        <property type="term" value="P:kinetochore assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031297">
        <property type="term" value="P:replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22921">
        <property type="entry name" value="HFD_CENP-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018552">
        <property type="entry name" value="CENP-X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28680">
        <property type="entry name" value="CENTROMERE PROTEIN X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28680:SF1">
        <property type="entry name" value="CENTROMERE PROTEIN X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09415">
        <property type="entry name" value="CENP-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="37"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="63"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAG04013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="183" mass="19882" checksum="85BC607A62C7904D" modified="2016-09-07" version="1">MPPKAAPTARRKGPSFNPPRPIKPANSASTARGAPKATTTRPAPVKSSASRSGFQPATTILSSDEEQEDEFDDLPSDIDALMEDALDDELRPQQPAALDLSTPPIPAPLLVRLLHHNFQDEGTQIQKGAMNLFGSYMSIFVREAIARAKDERERAARNGGGPGSRFLQVEDLEKLVPELLLDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C8S5</accession>
    <name>A0A177C8S5_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_866573</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG03796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034161.1">
        <property type="nucleotide sequence ID" value="XM_018187713.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C8S5"/>
    <dbReference type="GeneID" id="28771199"/>
    <dbReference type="InParanoid" id="A0A177C8S5"/>
    <dbReference type="OrthoDB" id="329272at2759"/>
    <dbReference type="UniPathway" id="UPA00113">
        <property type="reaction ID" value="UER00529"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006048">
        <property type="term" value="P:UDP-N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="2">
        <location>
            <begin position="155"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG03796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="292" mass="32245" checksum="5AC03751FCED3EBC" modified="2016-09-07" version="1">MTTVTSGFGFAANGNGNGGTEFLSMLAPPKNDLTEYDNTKPHSRQPASIPQVFRDAMSVREEVYGEQGVPLEAEFDEDDARSWHWVVYASVASTASTPPKHMRAEGSTTKEEDTRRASASASRLPVGTVRLIPAPHGPNKYLESPDKHSDADPPGGTTASEKKHPTEPYVKLGRLAVLAPYRKLGLAKLLINTAIDYAAKHPDTIYQPPSPTTMELANLRGQATHDAATWQGLVMIHAQANLKNYWEKHFGFKEELRSENGEVQIAKEPHWVEEGIEHVGMWKRLKIDNGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C921</accession>
    <name>A0A177C921_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1166978</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG03257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033622.1">
        <property type="nucleotide sequence ID" value="XM_018179095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C921"/>
    <dbReference type="GeneID" id="28762581"/>
    <dbReference type="InParanoid" id="A0A177C921"/>
    <dbReference type="OrthoDB" id="3923077at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG03257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="105" mass="11810" checksum="799244BEEB2860E4" modified="2016-09-07" version="1" fragment="single">MTQLMTPWFNKGALIPIPEMTRVGINPNTVAHCIILVRENETNLPTRQPHNTLTDASADLAICWTLEAYMALLAASVPTFKPVVRRKGNQTNTQNIYRLCLRFAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C931</accession>
    <name>A0A177C931_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">magnesium chelatase</fullName>
            <ecNumber evidence="1">6.6.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_1151716</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Porphyrin-containing compound metabolism.</text>
    </comment>
    <dbReference type="EC" id="6.6.1.1" evidence="1"/>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG03267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033632.1">
        <property type="nucleotide sequence ID" value="XM_018176762.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C931"/>
    <dbReference type="GeneID" id="28760248"/>
    <dbReference type="InParanoid" id="A0A177C931"/>
    <dbReference type="OrthoDB" id="444631at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016851">
        <property type="term" value="F:magnesium chelatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.80">
        <property type="entry name" value="Magnesium chelatase subunit I, C-Terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041628">
        <property type="entry name" value="ChlI/MoxR_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052041">
        <property type="entry name" value="Nucleic_acid_metab_PIN/TRAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11603">
        <property type="entry name" value="AAA FAMILY ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11603:SF132">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17863">
        <property type="entry name" value="AAA_lid_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ChlI/MoxR AAA lid" evidence="3">
        <location>
            <begin position="270"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAG03267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="365" mass="40376" checksum="74223CA1CE64A11F" modified="2016-09-07" version="1">MDDFGDRIADKVQALSDIELAALLCLITDQHCIIEGEKQSLDELEHEIRLVARNLFGLTWAVLECSESTTVDEFGAGILVDEIAGDYFSLANRSAREEDLRYAAQPGSPKKFTGRSSRPFTPLDSRKIANVVIAKNFNIASNQVQVQALELIRGKRNFTRTAVHAAPKPFLFIALNAIGTASLSLHLNDQLFISHKHQIEDGFPNLEELHEKEPIYDDDASTSSVVRSPPKQEDSVMFTEADLNELTNLTAKVSISTEVRAYLHNIVIFMRQHRAVGGGISAMATRHFDMLSRALAPLHGLSYITPALVALAARKVYPHRIKITTPENERSLQWGSSLDAVRAVLEGVTPDDVVEEVLQSVEVPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C9H2</accession>
    <name>A0A177C9H2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">4-coumarate-CoA ligase 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1122784</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG03502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033867.1">
        <property type="nucleotide sequence ID" value="XM_018175642.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C9H2"/>
    <dbReference type="STRING" id="1460663.A0A177C9H2"/>
    <dbReference type="GeneID" id="28759128"/>
    <dbReference type="InParanoid" id="A0A177C9H2"/>
    <dbReference type="OrthoDB" id="6509636at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016405">
        <property type="term" value="F:CoA-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.980">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.38.10">
        <property type="entry name" value="Luciferase, Domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096:SF422">
        <property type="entry name" value="BCDNA.GH02901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="1">
        <location>
            <begin position="48"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="2">
        <location>
            <begin position="455"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG03502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="561" mass="61881" checksum="442B53D45FD6E0C0" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C9N9</accession>
    <name>A0A177C9N9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Chitin synthesis regulation, congo red resistance, RCR protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1177548</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG03549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033914.1">
        <property type="nucleotide sequence ID" value="XM_018180290.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C9N9"/>
    <dbReference type="GeneID" id="28763776"/>
    <dbReference type="InParanoid" id="A0A177C9N9"/>
    <dbReference type="OrthoDB" id="3556830at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020999">
        <property type="entry name" value="Chitin_synth_reg_RCR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28187">
        <property type="entry name" value="PROTEIN RCR1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28187:SF1">
        <property type="entry name" value="PROTEIN RCR1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12273">
        <property type="entry name" value="RCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="66"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="88"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG03549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="155" mass="17483" checksum="FD48F1A7118E5A52" modified="2016-09-07" version="1">MARCRDQYGRYYNCSSRWNDWVRWVVLAVVVIGFFLLFVMCSCITARRRRKAGRQPFYGTGWAHRPGGNAQPYYNNNNYAQPPPQYTPQPQQGSYYGTGANQGYYGNNGQQPYPYGQANGVELQQPPQSHLARGGEDVYTPPPGPPPTKGDGIIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C9Z8</accession>
    <name>A0A177C9Z8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">p-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CC84DRAFT_1096471</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG03550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033915.1">
        <property type="nucleotide sequence ID" value="XM_018174670.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C9Z8"/>
    <dbReference type="STRING" id="1460663.A0A177C9Z8"/>
    <dbReference type="GeneID" id="28758156"/>
    <dbReference type="InParanoid" id="A0A177C9Z8"/>
    <dbReference type="OrthoDB" id="2011769at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098852">
        <property type="term" value="C:lytic vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04159">
        <property type="entry name" value="Arl10_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001015">
        <property type="entry name" value="ADP-ribosylation factor-like protein 8B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044154">
        <property type="entry name" value="Arl8a/8b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45732">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45732:SF7">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="27"/>
            <end position="34"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="130"/>
            <end position="133"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAG03550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="183" mass="20619" checksum="A699F02F61AADD5A" modified="2016-09-07" version="1">MASIFRRIYDWLLRLFWATEMDITMIGLQNAGKTSLLRVLAGGEFTVDSIPTVGFNMKRVQKGHVTLKCWDLGGQPRFRSMWERYCRGVNAMVFIVDSADRDALPVAREELKLLLEKPALEGIPLLVLGNKSDLPNKLSVDELIDALNLKAVSHREVSCYGISAKEETNLDAVLQWLIARASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CA13</accession>
    <name>A0A177CA13_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CC84DRAFT_860350</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG03597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033962.1">
        <property type="nucleotide sequence ID" value="XM_018187662.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CA13"/>
    <dbReference type="GeneID" id="28771148"/>
    <dbReference type="InParanoid" id="A0A177CA13"/>
    <dbReference type="OrthoDB" id="4685598at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.240.10:FF:000008">
        <property type="entry name" value="C6 zinc finger domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053181">
        <property type="entry name" value="EcdB-like_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47785:SF2">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47785">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="130"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="59"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="88"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAG03597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="707" mass="77757" checksum="5EF0483ECEF387AE" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CB93</accession>
    <name>A0A177CB93_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1207208</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG03980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034345.1">
        <property type="nucleotide sequence ID" value="XM_018182084.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CB93"/>
    <dbReference type="GeneID" id="28765570"/>
    <dbReference type="InParanoid" id="A0A177CB93"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG03980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="334" mass="36866" checksum="CA3E50A18886050A" modified="2016-09-07" version="1">MQQFLCRGPFAARRLPMLLAYAGHSSNHTTPYQDPYIRGMSVFASSVGQRTLLRIELTDSLLSMTTATTGIVTCVGCESARMQQTKSTISNSDFREHLPGPLFHSSDHFILLSSRLSSAWHVVYCRNKTFMAHERFETCQSITHSLLATDRHLTSSVWFRGGMASSLGHISALPIGHATCIPSWTIGLGASTRSIFCFVSFERINNSALLAQLYETFRASPSGSAARGPPAINGRMSSLMSKPTLADHAAPANPERDPHLNMGLWGEACAFRRSDPPFWRLLATCSMHSWHDFSLPTQRRQQDPASCSLCSRWFASQIHNAHVCAPSKSTQDSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CBP4</accession>
    <name>A0A177CBP4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Endo-1,5-alpha-L-arabinanase A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CC84DRAFT_1249743</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Glycan metabolism; L-arabinan degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the glycosyl hydrolase 43 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG04120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034485.1">
        <property type="nucleotide sequence ID" value="XM_018184292.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CBP4"/>
    <dbReference type="STRING" id="1460663.A0A177CBP4"/>
    <dbReference type="GeneID" id="28767778"/>
    <dbReference type="InParanoid" id="A0A177CBP4"/>
    <dbReference type="OrthoDB" id="3879658at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08999">
        <property type="entry name" value="GH43_ABN-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050727">
        <property type="entry name" value="GH43_arabinanases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006710">
        <property type="entry name" value="Glyco_hydro_43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43301">
        <property type="entry name" value="ARABINAN ENDO-1,5-ALPHA-L-ARABINOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43301:SF3">
        <property type="entry name" value="ARABINAN ENDO-1,5-ALPHA-L-ARABINOSIDASE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04616">
        <property type="entry name" value="Glyco_hydro_43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012339455" description="Endo-1,5-alpha-L-arabinanase A" evidence="9">
        <location>
            <begin position="16"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="47"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="224"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate" evidence="7">
        <location>
            <position position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00042202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAG04120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="332" mass="37284" checksum="49C2E24B71FF4BF9" modified="2016-09-07" version="1">MLFALLAVLTASALASPLSLADTQLQARDAPCTGGVEGPFLETNFPDPSLTNVDGTWFSFATWNGKDFRGAESKNFTDWKRFESGKLLAIEEATWANANRMWAPDVMRRAHDGKYVMYFTADDKQKEGSQCIGAAISDKIHGLYHPVNDFVQCNRSSHGVIDPAWFKDTDGRQYIVYKAENPSGRLEIREVAHSGPKEGVQWIGNAVYLLKPRDQGFWDGQNMEAPYIFKRNGIYFLTYSTHWTNNETYDVQYATSKNIMGPYTRVKEPLVSSGKKFGCELAGPGGASFQRFGNANKLRMVFHALGPERRVQQRPFYTATVHVNGEKLEIKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CCH8</accession>
    <name>A0A177CCH8_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">ATP-dependent RNA helicase SUB2</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">ATP-dependent RNA helicase sub2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">CC84DRAFT_1148134</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23 24">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">ATP-binding RNA helicase involved in transcription elongation and required for the export of mRNA out of the nucleus. SUB2 also plays a role in pre-mRNA splicing and spliceosome assembly. May be involved in rDNA and telomeric silencing, and maintenance of genome integrity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the DEAD box helicase family. DECD subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG05026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035391.1">
        <property type="nucleotide sequence ID" value="XM_018176620.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CCH8"/>
    <dbReference type="FunCoup" id="A0A177CCH8">
        <property type="interactions" value="1209"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CCH8"/>
    <dbReference type="GeneID" id="28760106"/>
    <dbReference type="InParanoid" id="A0A177CCH8"/>
    <dbReference type="OrthoDB" id="10265785at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000346">
        <property type="term" value="C:transcription export complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031509">
        <property type="term" value="P:subtelomeric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006283">
        <property type="term" value="P:transcription-coupled nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd17950">
        <property type="entry name" value="DEADc_DDX39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000111">
        <property type="entry name" value="DEAD-box ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000168">
        <property type="entry name" value="DEAD-box ATP-dependent RNA helicase 56-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0347">Helicase</keyword>
    <keyword evidence="6 23" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="11" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="22">
        <location>
            <begin position="51"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="20">
        <location>
            <begin position="82"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="21">
        <location>
            <begin position="271"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="18">
        <location>
            <begin position="51"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="19">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00037698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00038213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00040177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00040402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="OAG05026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="437" mass="49451" checksum="C551C92C35C77391" modified="2016-09-07" version="1">MSHEEDLIDYSDEEIQPTEAPANGTAGAAKGLAADDAAGDKKGSYVGIHSTGFRDFLLKDELIRAITDCGFEHPSEVQQTTIPQAILGNDVLCQAKSGLGKTAVFVLATLQQLDEKPEAGVATVLVMCHTRELAYQIKNEYNRFAKFLPDIKVGVFYGGTPIQEDIRILKDKETHPHIIVGTPGRINALVRDKVLRLSNLKHFVLDECDKMLDQNDMRNDVQTIFRATPAHKQVMMFSATLSEEIKLTCKKFMQSPLEIYIDNEKKLTLHGLQQYYMKLEEREKNRKLNDLLDTLEFNQVIIFVRSTQRCTELDKLLRECNFPSTAVHSGIGQEERIKRYKEFKDFQTRICVSTDIFGRGIDVERINVAINYDMPDKADSYLHRVGRAGRFGTKGLSISFVSNPDDETVLKEIEKRFEVELPEFPAEGVDASTYMDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CDN0</accession>
    <name>A0A177CDN0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HET-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1093846</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG04810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035175.1">
        <property type="nucleotide sequence ID" value="XM_018174538.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CDN0"/>
    <dbReference type="GeneID" id="28758024"/>
    <dbReference type="InParanoid" id="A0A177CDN0"/>
    <dbReference type="OrthoDB" id="2157530at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF73">
        <property type="entry name" value="HET DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_8G01020)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="48"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG04810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="182" mass="21140" checksum="EAC4B126DC4A0F1E" modified="2016-09-07" version="1" fragment="single">MVGILSAYKYQGLVDEDEIRLLVVEPGNQDEDLRCSLVHARLSDRPDFEAISYTWGTDAPSKQILLDGHIFPVRNNIYHALKRYRHATRQRILWADAISINQDDIPERSSQVKLMKKVYMYASHVLIWLGPNLEHDDLANADVRALVERESKRNADTVTALQEFFTRSWFSRMWILQELVVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CEH1</accession>
    <name>A0A177CEH1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Inosine triphosphate pyrophosphatase</fullName>
            <shortName evidence="13">ITPase</shortName>
            <shortName evidence="13">Inosine triphosphatase</shortName>
            <ecNumber evidence="13">3.6.1.66</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Non-canonical purine NTP pyrophosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Non-standard purine NTP pyrophosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Nucleoside-triphosphate diphosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Nucleoside-triphosphate pyrophosphatase</fullName>
            <shortName evidence="13">NTPase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">XTP/dITP diphosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CC84DRAFT_1164173</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) or xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions.</text>
    </comment>
    <comment type="function">
        <text evidence="9">Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triphosphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ITP + H2O = IMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:29399"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
            <dbReference type="EC" id="3.6.1.66"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:29400"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>N(6)-hydroxy-dATP + H2O = N(6)-hydroxy-dAMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:83971"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:233529"/>
            <dbReference type="ChEBI" id="CHEBI:233530"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:83972"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>XTP + H2O = XMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:28610"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57464"/>
            <dbReference type="ChEBI" id="CHEBI:61314"/>
            <dbReference type="EC" id="3.6.1.66"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>dITP + H2O = dIMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:28342"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61194"/>
            <dbReference type="ChEBI" id="CHEBI:61382"/>
            <dbReference type="EC" id="3.6.1.66"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:28343"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="13">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="13">Binds 1 divalent metal cation per subunit; can use either Mg(2+) or Mn(2+).</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 13 14">Belongs to the HAM1 NTPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.66" evidence="13"/>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG05706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036071.1">
        <property type="nucleotide sequence ID" value="XM_018178435.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CEH1"/>
    <dbReference type="FunCoup" id="A0A177CEH1">
        <property type="interactions" value="735"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CEH1"/>
    <dbReference type="GeneID" id="28761921"/>
    <dbReference type="InParanoid" id="A0A177CEH1"/>
    <dbReference type="OrthoDB" id="6288734at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035870">
        <property type="term" value="F:dITP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036220">
        <property type="term" value="F:ITP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036222">
        <property type="term" value="F:XTP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009204">
        <property type="term" value="P:deoxyribonucleoside triphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00515">
        <property type="entry name" value="HAM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.950.10:FF:000003">
        <property type="entry name" value="Inosine triphosphate pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03148">
        <property type="entry name" value="HAM1_NTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027502">
        <property type="entry name" value="ITPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029001">
        <property type="entry name" value="ITPase-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002637">
        <property type="entry name" value="RdgB/HAM1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00042">
        <property type="entry name" value="RdgB/HAM1 family non-canonical purine NTP pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11067:SF9">
        <property type="entry name" value="INOSINE TRIPHOSPHATE PYROPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11067">
        <property type="entry name" value="INOSINE TRIPHOSPHATE PYROPHOSPHATASE/HAM1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01725">
        <property type="entry name" value="Ham1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52972">
        <property type="entry name" value="ITPase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 13 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8 13" id="KW-0464">Manganese</keyword>
    <keyword evidence="3 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 13" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="4 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="15"/>
            <end position="20"/>
        </location>
        <ligand>
            <name>ITP</name>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>ITP</name>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="71"/>
            <end position="72"/>
        </location>
        <ligand>
            <name>ITP</name>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="147"/>
            <end position="150"/>
        </location>
        <ligand>
            <name>ITP</name>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>ITP</name>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="173"/>
            <end position="174"/>
        </location>
        <ligand>
            <name>ITP</name>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00054940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00093218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00093255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00093271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OAG05706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="191" mass="21012" checksum="6DF6EC39897DD8EC" modified="2016-09-07" version="1">MGSRAAVPKHLNFITGNKNKLAEVQAILEGVIELRNQNVDLVEIQGTVEEVTLDKARRAADAINGPVLVEDTCLCFKAMNDLPGPYIKWFMLALGPAKLHHMLDGFDDKSAQAVCTFAYCEGPGHEPVLFQGRTDGKLVASRGPTVFGWDSCFEYEGTTYAEMDKSEKNKISHRGKALDKLKVWLASKVDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CEK9</accession>
    <name>A0A177CEK9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">H/ACA ribonucleoprotein complex subunit CBF5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Centromere-binding factor 5</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">H/ACA ribonucleoprotein complex subunit cbf5</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">H/ACA snoRNP protein CBF5</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Small nucleolar RNP protein CBF5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CC84DRAFT_1145367</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalytic subunit of H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ('psi') residues may serve to stabilize the conformation of rRNAs and play a central role in ribosomal RNA processing. The H/ACA snoRNP complex also mediates pseudouridylation of other types of RNAs. Catalyzes pseudouridylation at position 93 in U2 snRNA. Also catalyzes pseudouridylation of mRNAs; H/ACA-type snoRNAs probably guide pseudouridylation of mRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a uridine in mRNA = a pseudouridine in mRNA</text>
            <dbReference type="Rhea" id="RHEA:56644"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:14659"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>uridine in 5S rRNA = pseudouridine in 5S rRNA</text>
            <dbReference type="Rhea" id="RHEA:47036"/>
            <dbReference type="Rhea" id="RHEA-COMP:11730"/>
            <dbReference type="Rhea" id="RHEA-COMP:11731"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>uridine in snRNA = pseudouridine in snRNA</text>
            <dbReference type="Rhea" id="RHEA:51124"/>
            <dbReference type="Rhea" id="RHEA-COMP:12891"/>
            <dbReference type="Rhea" id="RHEA-COMP:12892"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the pseudouridine synthase TruB family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG05746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036111.1">
        <property type="nucleotide sequence ID" value="XM_018176505.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CEK9"/>
    <dbReference type="FunCoup" id="A0A177CEK9">
        <property type="interactions" value="1520"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CEK9"/>
    <dbReference type="GeneID" id="28759991"/>
    <dbReference type="InParanoid" id="A0A177CEK9"/>
    <dbReference type="OrthoDB" id="10250002at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031429">
        <property type="term" value="C:box H/ACA snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000495">
        <property type="term" value="P:box H/ACA sno(s)RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990481">
        <property type="term" value="P:mRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031118">
        <property type="term" value="P:rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031120">
        <property type="term" value="P:snRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02572">
        <property type="entry name" value="PseudoU_synth_hDyskerin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21148">
        <property type="entry name" value="PUA_Cbf5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2350.10:FF:000001">
        <property type="entry name" value="H/ACA ribonucleoprotein complex subunit CBF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2350.10">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.10">
        <property type="entry name" value="PUA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012960">
        <property type="entry name" value="Dyskerin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002501">
        <property type="entry name" value="PsdUridine_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002478">
        <property type="entry name" value="PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036974">
        <property type="entry name" value="PUA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004802">
        <property type="entry name" value="tRNA_PsdUridine_synth_B_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032819">
        <property type="entry name" value="TruB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004521">
        <property type="entry name" value="Uncharacterised_CHP00451"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00425">
        <property type="entry name" value="CBF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003280">
        <property type="entry name" value="PRK04270.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00451">
        <property type="entry name" value="unchar_dom_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23127">
        <property type="entry name" value="CENTROMERE/MICROTUBULE BINDING PROTEIN CBF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23127:SF0">
        <property type="entry name" value="H_ACA RIBONUCLEOPROTEIN COMPLEX SUBUNIT DKC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08068">
        <property type="entry name" value="DKCLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01472">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16198">
        <property type="entry name" value="TruB_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01509">
        <property type="entry name" value="TruB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01136">
        <property type="entry name" value="DKCLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00359">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50890">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dyskerin-like" evidence="14">
        <location>
            <begin position="24"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="PUA" evidence="13">
        <location>
            <begin position="274"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="368"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="368"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="384"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="463"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00056777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00072225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00077661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00081789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00082909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM01136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OAG05746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="493" mass="54685" checksum="A190BCAF9C819EBA" modified="2016-09-07" version="1">MALVKQDAAPDYTIKPQAAAAPIDTSDWPLLLKNYSDLLVRTAHFTPIPAGCSPHARDLKQYVSSGVINLDKPSNPSSHEVVAWIKRILRVEKTGHSGTLDPKVTGCLIVCIDRATRLVKSQQGAGKEYVCVIRLHDKLPGGEAQFARALETLTGALFQRPPLISAVKRQLRIRTIHESKLYEFDNERQLGVFWVSCEAGTYIRTLCVHLGLLLGVGAHMQELRRVRSGAMDESKDMVTLHDVMDAQWMQDNNRDEEYLRYVISPLETLLTSYKRIVVKDSSVNAICYGAKLMVPGLLRFEKNIELHEEVVLMTTKGEAIALAYAQMSAVEMSTCDHGVVARIKRVIMERDLYPRRWGLGPVATEKKKMKENGTLDKFGRNNEKTPATWTSNYKDYDAQNQGSTDVTMGETTTTSDVLAAPAVPPTGLDANGEAEAEAEISKSKKRKSRGDEEEETVEEKAARKAAKKAKKEAKAAKKEKRKSKGGAESEDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CEP7</accession>
    <name>A0A177CEP7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1217008</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG05681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036046.1">
        <property type="nucleotide sequence ID" value="XM_018182857.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CEP7"/>
    <dbReference type="GeneID" id="28766343"/>
    <dbReference type="InParanoid" id="A0A177CEP7"/>
    <dbReference type="OrthoDB" id="3045089at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054464">
        <property type="entry name" value="ULD_fung"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22893">
        <property type="entry name" value="ULD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="1">
        <location>
            <begin position="2"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF22893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG05681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="55" mass="6896" checksum="DCB042D1125AF606" modified="2016-09-07" version="1">MLFEDVLGRTHRLPYEYFRHWDIFKANLREIFQHHIGWSLIEQNQFHVIDANWVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CFH9</accession>
    <name>A0A177CFH9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1205271</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG05477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035842.1">
        <property type="nucleotide sequence ID" value="XM_018181963.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CFH9"/>
    <dbReference type="STRING" id="1460663.A0A177CFH9"/>
    <dbReference type="GeneID" id="28765449"/>
    <dbReference type="InParanoid" id="A0A177CFH9"/>
    <dbReference type="OrthoDB" id="5428787at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG05477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="474" mass="50316" checksum="EF029F447E276A45" modified="2016-09-07" version="1" fragment="single">MASPSDAQKYLRASILHSRIHHRATYTRFSCSFVRSLRFRLLDAMRSPTVLAVLAALPAISAQVTSAPATRISTVFSTETGLPCSTLKGPTPFVIFGITTSFQFTYTVTQNNTLPPSTFHSANTVTVTRNSTTVTSLLTTTATATITSTVTPAVVTVSPSPGWLPLQGAQAVASATPLPRIARGALEGQSMPFNLFKRDEPITRQIGWIADPETGARVPIERTWYTLAVFCPVRVTQSLEYYVTDPDVTTTQQATGTAVATTTVTTTTSTIVSAPTPTFWAACQANNIVNHIDYDVNGKPLYFDGVYFRRGSGNNTDINEIGVDATNAVDCCIRCQSAPEGCSEAFFVPGEGKCQMRLRRTISPVAGVAALVVPSEFPTGTATGALAASTGGVNINAVCPGGSMSDYVGVIRGREGFNPKFAWSFTNGPCGRLSVNTVPQDFPANVTVPEVGSAESGVATVERPFKRAVKELSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CFQ0</accession>
    <name>A0A177CFQ0_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">FUN14-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CC84DRAFT_1164107</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FUN14 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG05628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035993.1">
        <property type="nucleotide sequence ID" value="XM_018178412.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CFQ0"/>
    <dbReference type="STRING" id="1460663.A0A177CFQ0"/>
    <dbReference type="GeneID" id="28761898"/>
    <dbReference type="InParanoid" id="A0A177CFQ0"/>
    <dbReference type="OrthoDB" id="3990500at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007014">
        <property type="entry name" value="FUN14"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04930">
        <property type="entry name" value="FUN14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012520380" description="FUN14-domain-containing protein" evidence="6">
        <location>
            <begin position="16"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAG05628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="158" mass="16975" checksum="A7EEFE0D33471348" modified="2016-09-07" version="1">MAFLLPGLRRGLVLSTPFILSAPLLVQTMRRPVLCDGPDPLSKITSDLKNRYAGEAQTPVIKTSGAPNPRALRQVSMGSILGVLAGLGVSVFSKPLAILIGLGVICIQLLESRGIHLVPYSFLQRRLKETNVRSLIQDNAAFKLSFGATFALAAFAEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CG15</accession>
    <name>A0A177CG15_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1119428</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG05902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036267.1">
        <property type="nucleotide sequence ID" value="XM_018175550.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CG15"/>
    <dbReference type="STRING" id="1460663.A0A177CG15"/>
    <dbReference type="GeneID" id="28759036"/>
    <dbReference type="InParanoid" id="A0A177CG15"/>
    <dbReference type="OrthoDB" id="5378975at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031355">
        <property type="entry name" value="YBL010C/LAA2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38698">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38698:SF1">
        <property type="entry name" value="FUNGAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17104">
        <property type="entry name" value="YBL010C_LAA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="366"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="394"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG05902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="491" mass="53154" checksum="042227B4C2A9D0A1" modified="2016-09-07" version="1">MADELAPPRKSTELEDSGTKDLGKPAESSSDEHFSDASEGRVEKPDRSTATSPIPVTRVERVDDEPSYGEVPGTEAYNKRTQDAVPDEVEIVPEGQRSRSASRVSISDRPYTPGGTQIPKTVVEKIDPDTPSHGDVPGTLAHDLRAADAVPDIVLKAPEPPEKAPEEGTPTASISRSPMSSGSEDDDNADDRDASAADVTDGASENDDDGFGDDFDDFEEGGEGDDFGDFDDGFQQGEEDAETTFDKAPEQPSIPAPSMGPPVLDFEDLATLEEIAIATQPYIDEIYPSQKEIPSITTNQAALRSIFLSERSESLWSQLVAPPPLQPPDWVRSRIRRLFLVSLGVPVDLDEILPASKQKKLVLPSIHIPGEKSPRPSADSRNGALGRVKKENASSTSVDSSASKSGKRKGPPPPPQLDISSTTMLCSTTDAALGNFTDQELQAHVKRLEELKERANEVFDYWQKRMESALGDKDAFEQVIESLVAHAKKLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CGG9</accession>
    <name>A0A177CGG9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Chitin deacetylase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CC84DRAFT_764791</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG06456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036821.1">
        <property type="nucleotide sequence ID" value="XM_018187359.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CGG9"/>
    <dbReference type="FunCoup" id="A0A177CGG9">
        <property type="interactions" value="40"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CGG9"/>
    <dbReference type="GeneID" id="28770845"/>
    <dbReference type="InParanoid" id="A0A177CGG9"/>
    <dbReference type="OrthoDB" id="2125469at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10951">
        <property type="entry name" value="CE4_ClCDA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.370">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46471">
        <property type="entry name" value="CHITIN DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46471:SF9">
        <property type="entry name" value="CHITIN DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0170">Cobalt</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008058173" evidence="7">
        <location>
            <begin position="18"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="NodB homology" evidence="8">
        <location>
            <begin position="45"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAG06456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="251" mass="26347" checksum="B38AE1203E3E1227" modified="2016-09-07" version="1">MGFTTLLVASLAAATSAVPLMNPIQAIQAAGPPAGQVITKCSSPGMIALAYDDGPYQYTQKLADILSNGGAKGTFFVTGTLYGCIYNQKTALQNAYKAGHQIASHTWTHPHIGSLSASALTTEMTKLETALVNIIGVKPTYMRPPYLETSGSVLSTMKTLGYRVVTDDVDAEDWNGKTPAQSQAKFQAAGAGGNGHIPLMHETYQGTVETLTPWLINWAKQNNLKLVTVAECLGDAGGAYTNGTGNGQSSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CGP7</accession>
    <name>A0A177CGP7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cat eye syndrome critical region protein 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1258011</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG06744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037109.1">
        <property type="nucleotide sequence ID" value="XM_018184788.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CGP7"/>
    <dbReference type="STRING" id="1460663.A0A177CGP7"/>
    <dbReference type="GeneID" id="28768274"/>
    <dbReference type="InParanoid" id="A0A177CGP7"/>
    <dbReference type="OrthoDB" id="270009at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046474">
        <property type="term" value="P:glycerophospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000069">
        <property type="entry name" value="HAD-superfamily subfamily IIA hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050324">
        <property type="entry name" value="CDP-alcohol_PTase-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006357">
        <property type="entry name" value="HAD-SF_hydro_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006353">
        <property type="entry name" value="HAD-SF_hydro_IIA_CECR5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01456">
        <property type="entry name" value="CECR5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01460">
        <property type="entry name" value="HAD-SF-IIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14269">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--GLYCEROL-3-PHOSPHATE 3-PHOSPHATIDYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14269:SF57">
        <property type="entry name" value="SUPERFAMILY HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G02580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13344">
        <property type="entry name" value="Hydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13242">
        <property type="entry name" value="Hydrolase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG06744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="408" mass="45076" checksum="E99206368C4EE1EE" modified="2016-09-07" version="1">MASFPSLRQISRLASRHTSFTSPSPSILRPCTRASRSFQSTAAPPTVPEFAFAFDIDGVLVRSSDPLPRAHKALSYLQKHRIPFILLTNGGGKHEDERVADLSSKLDVPLSTSMFVQSHTPFADMHEYKDKTVMVVGGDGDKCRVVAEKYGFKTVVTPIDIISAYPEVWPFSQQLLPYYKAFMRPLPAPIDPASPSTSLKIDAVFVYNDPRDWGLDTQIIKDVLLSREGIMGTLSKKNGDATLPNKGYQQDGQPPLYFSNPDLLWAAKYHLPRLGQGGFREALEGVWAALTGGPSAGVELQKIVMGKPHQPTYAFAEKRLIAHRETLLKQVDAQAGQLKRVYMVGDNPESDILGGNSYESPHGTDWASVLVQTGVYVEGTEPAHRPRKMVGDVWDAVEWAVGEEGWKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CHI3</accession>
    <name>A0A177CHI3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mediator complex subunit 15 KIX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CC84DRAFT_1176340</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG06318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036683.1">
        <property type="nucleotide sequence ID" value="XM_018180214.1"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CHI3"/>
    <dbReference type="GeneID" id="28763700"/>
    <dbReference type="InParanoid" id="A0A177CHI3"/>
    <dbReference type="OrthoDB" id="3918840at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036546">
        <property type="entry name" value="MED15_KIX"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16987">
        <property type="entry name" value="KIX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mediator complex subunit 15 KIX" evidence="4">
        <location>
            <begin position="513"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="200"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="323"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="376"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="613"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="763"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="876"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1172"/>
            <end position="1212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1256"/>
            <end position="1407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1532"/>
            <end position="1597"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1609"/>
            <end position="1654"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1706"/>
            <end position="1824"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1863"/>
            <end position="1893"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="37"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="211"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="222"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="328"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="622"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="638"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="665"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1172"/>
            <end position="1191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1256"/>
            <end position="1268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1269"/>
            <end position="1280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1297"/>
            <end position="1315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1338"/>
            <end position="1354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1358"/>
            <end position="1371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1535"/>
            <end position="1548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1555"/>
            <end position="1573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1618"/>
            <end position="1640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1765"/>
            <end position="1793"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1807"/>
            <end position="1819"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1866"/>
            <end position="1887"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAG06318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="1975" mass="215325" checksum="570DC7877A09FE76" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CIA0</accession>
    <name>A0A177CIA0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Short chain dehydrogenase/reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_644934</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG07235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037600.1">
        <property type="nucleotide sequence ID" value="XM_018186998.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CIA0"/>
    <dbReference type="STRING" id="1460663.A0A177CIA0"/>
    <dbReference type="GeneID" id="28770484"/>
    <dbReference type="InParanoid" id="A0A177CIA0"/>
    <dbReference type="OrthoDB" id="37659at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052178">
        <property type="entry name" value="Sec_Metab_Biosynth_SDR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618">
        <property type="entry name" value="7-ALPHA-HYDROXYSTEROID DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618:SF2">
        <property type="entry name" value="CHAIN DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G06930)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAG07235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="253" mass="26905" checksum="0CFC13FAC2A43771" modified="2016-09-07" version="1">MPYSLKGRNVLVTGGSAGLGETISISFAKEGANVAVNYFNRVEPAQNVVQACEKQGVKAVAIKGDMCDTSECRRVVEETIKQLGGIDVVISNAGWTRFSDFADLDSMSEDEWDKCWAANVKAPLALLKAAKPTFESNPDGGAFISSGSIAAVSQAGSSMPYAVTKAAQLQLIKCLGATQGPKIRVNTVLPGLLLTEWGRKYSDEKIQWAKNTAALKHETDLQDCADAFIMLAKNTSITGARIQVDAGLNVQGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CIX2</accession>
    <name>A0A177CIX2_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SMODS and SLOG-associating 2TM effector domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1163616</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG07465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037830.1">
        <property type="nucleotide sequence ID" value="XM_018178306.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CIX2"/>
    <dbReference type="GeneID" id="28761792"/>
    <dbReference type="InParanoid" id="A0A177CIX2"/>
    <dbReference type="OrthoDB" id="4472872at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041622">
        <property type="entry name" value="SLATT_fungi"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF033635">
        <property type="entry name" value="SLATT_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38793">
        <property type="entry name" value="SLATT_FUNGAL DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38793:SF3">
        <property type="entry name" value="SMODS AND SLOG-ASSOCIATING 2TM EFFECTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18142">
        <property type="entry name" value="SLATT_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="SMODS and SLOG-associating 2TM effector" evidence="2">
        <location>
            <begin position="62"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG07465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="216" mass="23997" checksum="B6DA2DE8A01F83D9" modified="2016-09-07" version="1">MPVPMMYDYTEETPLLIAGDATTPRNPKDIHLQFCALAGVPPSNIPKPTSTSPAARRSLYGRAVHKRNVQNRTYMFTAALTNTLLLSQVVLGAALTGLGASASSHILITVFGALNTIIAGLVAYLKSRGQPMRARMFRDDLERVVDEMENSEVMWLGIQAGAHGYDEIAIDGEVSVRSEVARLTRLYDKVVRNNTMNDREFPSLFFLCFVHRLWLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CJ81</accession>
    <name>A0A177CJ81_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Mitochondrial export translocase Oxa2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CC84DRAFT_1089758</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the OXA1/ALB3/YidC family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG07594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037959.1">
        <property type="nucleotide sequence ID" value="XM_018174323.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CJ81"/>
    <dbReference type="STRING" id="1460663.A0A177CJ81"/>
    <dbReference type="GeneID" id="28757809"/>
    <dbReference type="InParanoid" id="A0A177CJ81"/>
    <dbReference type="OrthoDB" id="2148490at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032977">
        <property type="term" value="F:membrane insertase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032979">
        <property type="term" value="P:protein insertion into mitochondrial inner membrane from matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001708">
        <property type="entry name" value="YidC/ALB3/OXA1/COX18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12428:SF65">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX18, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12428">
        <property type="entry name" value="OXA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAG07594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="362" mass="39945" checksum="685E91763DA725C5" modified="2016-09-07" version="1">MLSARLLRPPGRQLLSRAPILPSQPRSISRTRAFHATAPRKDGALDTLLYLPHEMVSLIHNYVPWYAALPLTAFLVRGLLVTTAGSYARALTARYIGTHPVRQALAYQKRNELMQRGGYTNPKEARTEIAKAVKAETAALDQRWNCTLRASVAWTLAQIPIFFTMAEVIRQMTGTRDGLLGIVMGTLGLKEKSDAVHGIDLVGNQWFQPSLADEGMLWFPNLLTPDPILPFVVSALMFTNVYFTKNGASANPDSLPTFSRAVRLSLMGASLAIGPLCQDLPAALMLYWAGSTSSVMLWNLWLDRKYPSPRGFTACKRPLQLLAAPKPDARIRPGLGLPMAKAKTVLPQMQGKRRPRRSAPHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CJF4</accession>
    <name>A0A177CJF4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_631563</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG06960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037325.1">
        <property type="nucleotide sequence ID" value="XM_018186950.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CJF4"/>
    <dbReference type="STRING" id="1460663.A0A177CJF4"/>
    <dbReference type="GeneID" id="28770436"/>
    <dbReference type="InParanoid" id="A0A177CJF4"/>
    <dbReference type="OrthoDB" id="4159781at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540">
        <property type="entry name" value="TRANSCRIPTION FACTOR (ACR-2), PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540:SF5">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG06960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="455" mass="51484" checksum="FB7352CCC85CDA15" modified="2016-09-07" version="1">MVSQQKTPDQGRWAFVTTSPTTRCPTAAQRTLMRKHIMKDIGYSRRACHYSSRSSSVSGAGGIPGQTDGAPEVIKPTAIPRAFPSTATALVTVNDDARCVLHYVFSDALPSYIRVYREKWYPVCVQDNAAFHQMLACCATHLYRWQPEKHHRLKRVAISEHAQALTIAREHLRGVTHLVSEDYLVVILMFACYAHMLNDLATFKMHMAAIRNIVSFRTSDISEEFMRLYQSIDSIGSYAFGITPSSLIPTTMTLPTLTHSTLGKPLSVLISSLDLKYRLTMLQAYQSLQNLDHYLALVHVNPGSSLLDEPYKLDLLVEPVSRCFLSLRIPTDMPAKDSAPLTYLCAGGLLYLAELRRRSGISPVMTTFHVDKLKQSLESMAHYLNIDPSIHLWVLTVGALESTSLDDQYYFCSQIKQLRTNEGIETMKQYEEHLHWVVWFDPLYQTRLSALFPMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CJK0</accession>
    <name>A0A177CJK0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HET-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1216592</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG07673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038038.1">
        <property type="nucleotide sequence ID" value="XM_018182821.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CJK0"/>
    <dbReference type="STRING" id="1460663.A0A177CJK0"/>
    <dbReference type="GeneID" id="28766307"/>
    <dbReference type="InParanoid" id="A0A177CJK0"/>
    <dbReference type="OrthoDB" id="20872at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058525">
        <property type="entry name" value="DUF8212"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF12">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26640">
        <property type="entry name" value="DUF8212"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="22"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="DUF8212" evidence="2">
        <location>
            <begin position="221"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG07673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="371" mass="42625" checksum="473BDB485E1C6617" modified="2016-09-07" version="1">MRLINCATLGFEEFIGKQVPPYLILSHTWETYEISYKDYCNIDDLRQESGLHVEKILKTCDIAKEKGYEYFWIDTCCIDKSSSAELTEAINSMFKWYSRAADCIVYLSDFDVRDPSADFARCRWFTRGWTLQELIAPRQVRFYDSRWRYYGRRLNLAPEISRITGIALSVISGHFISRSHSIAERMSWAAHRETTREEDLAYCLFGIFGVNLPLLYGEGPRAFMRLQEEILKASADLSIFAWRAEAPGTAFRGIFAHSVREFAHAKSILSNPPSAQFAVTNRGLRIERPLLSSTGHNLPGNDAGFLMSLGCRYSHMAPTKHLAIWLKKLGPEGTLVRFSVDQLSIMDRKWPSSKEIDQLQYIMRDTLAHED</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CJP1</accession>
    <name>A0A177CJP1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1163324</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG07088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037453.1">
        <property type="nucleotide sequence ID" value="XM_018178239.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CJP1"/>
    <dbReference type="GeneID" id="28761725"/>
    <dbReference type="InParanoid" id="A0A177CJP1"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG07088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="151" mass="16241" checksum="F8387893D8D0CDEA" modified="2016-09-07" version="1">MGYHTARDRIGDAPAITGGPFTLSNTPCGPGHVVRVSPRSLMGSTVDTNGDERQSHAMRSKHGEQESGPQACRPSLAHACLRADLPARARPYRSRPRRAFGTSKVQDERENGRMQERAEANAHYVIGCAAVTVLTRGLVGSLSCFGDAAWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CJV6</accession>
    <name>A0A177CJV6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">FAS1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_1143481</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG07148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037513.1">
        <property type="nucleotide sequence ID" value="XM_018176414.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CJV6"/>
    <dbReference type="STRING" id="1460663.A0A177CJV6"/>
    <dbReference type="GeneID" id="28759900"/>
    <dbReference type="InParanoid" id="A0A177CJV6"/>
    <dbReference type="OrthoDB" id="286301at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.180.10">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050904">
        <property type="entry name" value="Adhesion/Biosynth-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036378">
        <property type="entry name" value="FAS1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000782">
        <property type="entry name" value="FAS1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10900:SF77">
        <property type="entry name" value="FI19380P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10900">
        <property type="entry name" value="PERIOSTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02469">
        <property type="entry name" value="Fasciclin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00554">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82153">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50213">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008058259" evidence="2">
        <location>
            <begin position="17"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="3">
        <location>
            <begin position="18"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="3">
        <location>
            <begin position="180"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="309"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAG07148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="359" mass="36052" checksum="FE915EC0073DC168" modified="2016-09-07" version="1">MRTSLALAAYISAVLAQAPSLTDLIGSQPDLSTLGTALSSFPDLVAVLGSLSNITILAPTNSAFEALLAGDASLESTALSSNNTDAIQALLAYHVLNGTYVSSDFSETPAFAHTLLTPSGQSDSLTNVTGGQNVGLQLIGGNATIVSGELKGSNVVEADIQAANGVVVHKIDSVLTIPRNASTTLTAQSDVEVTSILSALTTANLVGTIDTIADLTIFVPNDAAFAAIASTLANASVEAITSILTYHAVAGAVVFSSDITNTTVKTVNGAELTLAVGTDGNAYIDNAKVVLPNIILSNGVAHIIDSVLNPESETPTPGNGTSTSAPVPSPTMSEFPGAAVKVQGAMGAAVVGFAVAMML</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CKH2</accession>
    <name>A0A177CKH2_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nucleotidylyl transferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1088062</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG07339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037704.1">
        <property type="nucleotide sequence ID" value="XM_018174234.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CKH2"/>
    <dbReference type="FunCoup" id="A0A177CKH2">
        <property type="interactions" value="36"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CKH2"/>
    <dbReference type="GeneID" id="28757720"/>
    <dbReference type="InParanoid" id="A0A177CKH2"/>
    <dbReference type="OrthoDB" id="5591297at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000309">
        <property type="term" value="F:nicotinamide-nucleotide adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31285">
        <property type="entry name" value="NICOTINAMIDE MONONUCLEOTIDE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31285:SF0">
        <property type="entry name" value="NICOTINAMIDE MONONUCLEOTIDE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG07339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="304" mass="33682" checksum="46BD399D9A42F83F" modified="2016-09-07" version="1">MSTRISTLRSLLPSLQSSLETFNASPSKFHVVRTINPSPTQPRTLYILDSSFNPPSRAHLSLATSALNNRLQGEENPARLLLLFSTHNADKAPSPASFVQRIALMTVFAEDVLRNLQGSSSASEDTKNVSIDIGLTKEPYYTDKSVAIAAEAPEIYASKPIHVHLVGYDTLIRLCNPKYYAEYKPPLSALKPFFDAGHKLRVTQRPYDKNDSSSKEFGTVEDQEKYLQNIKDGALEKDGFEAGWGENIDMVEGTGMGISSTRVRKEAKDGNWDEVGRLCTEGVTAWIREEVLYAEDDSGKKMMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CLZ4</accession>
    <name>A0A177CLZ4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Histone chaperone domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1257164</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038636.1">
        <property type="nucleotide sequence ID" value="XM_018184703.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CLZ4"/>
    <dbReference type="GeneID" id="28768189"/>
    <dbReference type="InParanoid" id="A0A177CLZ4"/>
    <dbReference type="OrthoDB" id="4357148at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG08271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="99" mass="10416" checksum="D8ED208D9E40B45B" modified="2016-09-07" version="1">MSSNEQIPIGDAGDNDYASRTGQSTIPVQRDEAPVEDPYGSGNADSDEQLERDEKDAIDSSNIIDSRTRGATKQAGTYAEPGDDEGLPGPEDGTSAGRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CMN2</accession>
    <name>A0A177CMN2_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CHCH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1214662</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038495.1">
        <property type="nucleotide sequence ID" value="XM_018182661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CMN2"/>
    <dbReference type="STRING" id="1460663.A0A177CMN2"/>
    <dbReference type="GeneID" id="28766147"/>
    <dbReference type="InParanoid" id="A0A177CMN2"/>
    <dbReference type="OrthoDB" id="10250105at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039870">
        <property type="entry name" value="Coa4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13639">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 4 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13639:SF2">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 4 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG08130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="59" mass="6926" checksum="E0A541E15458DE85" modified="2016-09-07" version="1">MSNDAARTDALSKMQDDDEPDDWDKRIFSTGCADENMKLTDCYYEKKDWRLCKKEVSPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CMU9</accession>
    <name>A0A177CMU9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DnaJ-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CC84DRAFT_1194495</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038585.1">
        <property type="nucleotide sequence ID" value="XM_018181349.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CMU9"/>
    <dbReference type="FunCoup" id="A0A177CMU9">
        <property type="interactions" value="106"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CMU9"/>
    <dbReference type="GeneID" id="28764835"/>
    <dbReference type="InParanoid" id="A0A177CMU9"/>
    <dbReference type="OrthoDB" id="1690618at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0101031">
        <property type="term" value="C:protein folding chaperone complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051083">
        <property type="term" value="P:'de novo' cotranslational protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006450">
        <property type="term" value="P:regulation of translational fidelity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000054">
        <property type="term" value="P:ribosomal subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006452">
        <property type="term" value="P:translational frameshifting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23953">
        <property type="entry name" value="zuotin_NTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.840">
        <property type="entry name" value="Ribosome-associated complex head domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032003">
        <property type="entry name" value="RAC_head"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042569">
        <property type="entry name" value="RAC_head_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054076">
        <property type="entry name" value="ZUO1-like_ZHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044634">
        <property type="entry name" value="Zuotin/DnaJC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058871">
        <property type="entry name" value="Zuotin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43999">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43999:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16717">
        <property type="entry name" value="RAC_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21884">
        <property type="entry name" value="ZUO1-like_ZHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26185">
        <property type="entry name" value="Zuotin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="5">
        <location>
            <begin position="102"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="247"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="327"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="255"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="327"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAG08220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="446" mass="50831" checksum="32B741680229DF71" modified="2016-09-07" version="1">MTSAQVQINLPLPVLPAGWTAEKDFKPVGSLSHAIDRNIEPVGPHFLAHARRKRHKRTFSEDDRIQAQANVKKIEDDDEGEISEPEDPLMLQREAKDWKGQDHYAVLGITRYRWRATEEQIKRAHRRKVLKHHPDKKAAKGGTEDDQFFKCIQKATEVLSDPVKRRQFDSVDEAADVEPPSKSETKKGNFYKLWGKVFEAEGRFSRQQPVPKLGNEKSSKAEVENFYNFWYSFDSWRTFEYLDEDVPDDNENRDQKRHVERKNQNARRKKKTEDTARLRKLVDDALALDERIKLFRQQENASKNKRRLEKEAEQKRLAEEAAKAKEEEARLAAEREAAEKAQKADSKKAKEAAKNAAKKNKRVIRGAVKDANYFHGAGDAPASQIDGALNDVDVIITKLDNEEIAALTAKLSGAKGADAIKQVYQDEVKQLIGAGKLKEGELKSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CMV5</accession>
    <name>A0A177CMV5_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Arrestin-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_1085852</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Interacts with hulA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the arrestin family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038981.1">
        <property type="nucleotide sequence ID" value="XM_018174125.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CMV5"/>
    <dbReference type="GeneID" id="28757611"/>
    <dbReference type="InParanoid" id="A0A177CMV5"/>
    <dbReference type="OrthoDB" id="3892815at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011021">
        <property type="entry name" value="Arrestin-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050357">
        <property type="entry name" value="Arrestin_domain-protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188">
        <property type="entry name" value="ARRESTIN DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188:SF17">
        <property type="entry name" value="FI21816P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00339">
        <property type="entry name" value="Arrestin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arrestin-like N-terminal" evidence="3">
        <location>
            <begin position="23"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAG08616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="144" mass="16216" checksum="42A03EDF3DD93A9B" modified="2016-09-07" version="1" fragment="single">MGLFTSNRKSSPSLPIFALHLSNSQDKVFKPNDTIQGHVTLSTPTPLLPQAIEVSLWGHSSAWLRTSSGTGSETTYRHYRDNVPLFDVTFNIFTQPQQLEPGQSYSFPFQFRVPEGTGSHRIGGYKDDMDARWTVQPHHLPPTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CN73</accession>
    <name>A0A177CN73_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Signal peptidase complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CC84DRAFT_1162767</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Enhances the enzymatic activity of SPC and facilitates the interactions between different components of the translocation site.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SPCS2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039319.1">
        <property type="nucleotide sequence ID" value="XM_018178090.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CN73"/>
    <dbReference type="FunCoup" id="A0A177CN73">
        <property type="interactions" value="73"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CN73"/>
    <dbReference type="GeneID" id="28761576"/>
    <dbReference type="InParanoid" id="A0A177CN73"/>
    <dbReference type="OrthoDB" id="29558at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005787">
        <property type="term" value="C:signal peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045047">
        <property type="term" value="P:protein targeting to ER"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009582">
        <property type="entry name" value="Spc2/SPCS2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13085">
        <property type="entry name" value="MICROSOMAL SIGNAL PEPTIDASE 25 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13085:SF0">
        <property type="entry name" value="SIGNAL PEPTIDASE COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06703">
        <property type="entry name" value="SPC25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="41"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00045608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAG08954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="224" mass="24702" checksum="F94834883714E2B9" modified="2016-09-07" version="1">MSATTKIAVHSLSDLKNTTDDALPNYLHSLKFKQIHKQTDVRLVIGYTAVIIAGALFYYDWKFGWEASKPYTLPAVVAYFLLNTAFSYWLWFVEAGTVYEGEGKTGKVRIASSTKKHIPIYEVDVTFTPAGSSHPQKIHIRAPFTRWFTSDGYFIAKPFQQWLASEVPVVGAADPNNVVEEIGRGSEAENVLNASGNQSAIDILQQLKASGANVSAGSGRRRKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CNB9</accession>
    <name>A0A177CNB9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1162801</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG09004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039369.1">
        <property type="nucleotide sequence ID" value="XM_018178103.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CNB9"/>
    <dbReference type="GeneID" id="28761589"/>
    <dbReference type="InParanoid" id="A0A177CNB9"/>
    <dbReference type="OrthoDB" id="10509585at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG09004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="78" mass="8182" checksum="7868470348700111" modified="2016-09-07" version="1">MTYFSTCLPQNLLSSLCSSTSSTITSASTVTMGGLAIAICPSPPKTHASPHLRTPCTTPPTIVSQAPARSDMDNLRRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CRB8</accession>
    <name>A0A177CRB8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">DNA binding regulatory protein-like protein AmdX</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CC84DRAFT_1212864</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG09430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039795.1">
        <property type="nucleotide sequence ID" value="XM_018182485.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CRB8"/>
    <dbReference type="FunCoup" id="A0A177CRB8">
        <property type="interactions" value="702"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CRB8"/>
    <dbReference type="GeneID" id="28765971"/>
    <dbReference type="InParanoid" id="A0A177CRB8"/>
    <dbReference type="OrthoDB" id="6077919at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000343">
        <property type="entry name" value="C2H2 transcription factor (AmdX)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000576">
        <property type="entry name" value="C2H2 transcription factor (AmdX)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051059">
        <property type="entry name" value="VerF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626">
        <property type="entry name" value="MIP31509P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626:SF13">
        <property type="entry name" value="RESPIRATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="57"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="85"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="105"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="666"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="966"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="13"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="143"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="980"/>
            <end position="990"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAG09430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="1167" mass="125476" checksum="3CDA0A6B210B776F" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CRL6</accession>
    <name>A0A177CRL6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1160901</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG09851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040216.1">
        <property type="nucleotide sequence ID" value="XM_018177612.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CRL6"/>
    <dbReference type="STRING" id="1460663.A0A177CRL6"/>
    <dbReference type="GeneID" id="28761098"/>
    <dbReference type="InParanoid" id="A0A177CRL6"/>
    <dbReference type="OrthoDB" id="8119704at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050228">
        <property type="entry name" value="Carboxylesterase_BioH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43194">
        <property type="entry name" value="HYDROLASE ALPHA/BETA FOLD FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43194:SF2">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN LPX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="60"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG09851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="364" mass="40951" checksum="EE556C294B0EC7D8" modified="2016-09-07" version="1">MPFGPFALQWRRPSPNPPSSTPVPDGITRSWIHTPSGPLELLTALPSKSTSSSNEAKPPLFFAHGGFGCAEQWLNYMQYFAAAGHPCYAISYRGHGKSWYPWFWRMYFTTRGTMAEDLTAGVKYVEALEATRRGAPGTQVVLIAHSAGGALSQYALSRKMFQVQGFCMFAAVPGFGSWGCYSFWALTAPLHFTYRGYHSRYLLANVEQVKDAFFTAETPLRHVESFAKLLSPYESMLWPMQALNAFVTGPDVLSSITGWVRRGFVPSTSPSDKPVSEPSQRLFILAAQRDVLCTPTILEDAARRYRRAFRDMSLDNRLVFAQEQQDEEVDGVRFRVVDGVAHHMQNHEEWGKGADEVQKWLEQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CS85</accession>
    <name>A0A177CS85_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1069304</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG09637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040002.1">
        <property type="nucleotide sequence ID" value="XM_018173659.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CS85"/>
    <dbReference type="STRING" id="1460663.A0A177CS85"/>
    <dbReference type="GeneID" id="28757145"/>
    <dbReference type="InParanoid" id="A0A177CS85"/>
    <dbReference type="OrthoDB" id="10265389at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030014">
        <property type="term" value="C:CCR4-NOT complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019312">
        <property type="entry name" value="CNOT11"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10155">
        <property type="entry name" value="CNOT11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="275"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG09637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="349" mass="39689" checksum="CB137E663C9F3FE9" modified="2016-09-07" version="1" fragment="single">AALTRSEIHALSDADRTCEDANRQLASARAHVHRDHTAADTGVFEESLRLKNTLDACEQQAKSSPSWDALAVLVNCEYRLYVLNQTTPLRNNPFLSHWVEAVQRLGTPAAQRDANTDGSILSDEISTVRMELIKALLQSRNPSQFARASPRQLYNNYVELRQTSLFNIRTYVRMLEEEGIYERTPEPDSDSPESTSTASDNKLNEFQRWKLGMLSRLETEPEHAVAELTHLPLELSSLDFLTTLLQEHTLQALNIEPAPVIADFIQHALRMTEQMGRGPGETGAAESEPEPMLESGREAQTRAVKLLLLFMRNLIRKALLPLESIYFEIQEICVRYVWIREVREFRAFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CSY5</accession>
    <name>A0A177CSY5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_1193864</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040771.1">
        <property type="nucleotide sequence ID" value="XM_018181329.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CSY5"/>
    <dbReference type="STRING" id="1460663.A0A177CSY5"/>
    <dbReference type="GeneID" id="28764815"/>
    <dbReference type="InParanoid" id="A0A177CSY5"/>
    <dbReference type="OrthoDB" id="3357846at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015244">
        <property type="term" value="F:fluconazole transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990961">
        <property type="term" value="P:xenobiotic detoxification by transmembrane export across the plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF23">
        <property type="entry name" value="FLUCONAZOLE RESISTANCE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="161"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="185"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="219"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="260"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="326"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="365"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="405"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="437"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="465"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="500"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="92"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="35"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="35"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="49"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAG10406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="534" mass="58389" checksum="62EA5E4912A5BA3E" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CTA5</accession>
    <name>A0A177CTA5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">HET-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_1161622</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041130.1">
        <property type="nucleotide sequence ID" value="XM_018177789.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CTA5"/>
    <dbReference type="STRING" id="1460663.A0A177CTA5"/>
    <dbReference type="GeneID" id="28761275"/>
    <dbReference type="InParanoid" id="A0A177CTA5"/>
    <dbReference type="OrthoDB" id="20872at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058525">
        <property type="entry name" value="DUF8212"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF12">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26640">
        <property type="entry name" value="DUF8212"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="2">
        <location>
            <begin position="24"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="DUF8212" evidence="3">
        <location>
            <begin position="224"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="541"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="575"/>
            <end position="596"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF26640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAG10765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="596" mass="67182" checksum="139C372F15943A71" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CTD3</accession>
    <name>A0A177CTD3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1172488</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040374.1">
        <property type="nucleotide sequence ID" value="XM_018179983.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CTD3"/>
    <dbReference type="GeneID" id="28763469"/>
    <dbReference type="InParanoid" id="A0A177CTD3"/>
    <dbReference type="OrthoDB" id="3791925at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="183"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="246"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="291"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG10009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="322" mass="35630" checksum="A9D95A7CE0644B90" modified="2016-09-07" version="1">MESDTYTDPLASLFRPADKPRFASLNWPVWDGAIFDPNMRANRDSDKLAFIAGTVYVRHAVSLRRPKIMLKLLDQATLNHLARWGINGFVIGEERASERIERDRDLLASFRSGVLLAMDELRKAEVPNNVNQDDLKEVIDALESYVHGHFVEMAELGPAVAEAVRAEDALAQTNAMTMAEEFGSDGKYGESEEEGTTARKLQYDVSADETTAPTDRKSPNDSNTSATDYDGDDDDTLKYFEQVEILGDISSSSNDDGGEEDDIDTMSSSFAENERAHGANATHESEVASVRRAKRAKSKKAKKARSQARRDKKKVGTAQTES</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CTE5</accession>
    <name>A0A177CTE5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1172637</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040547.1">
        <property type="nucleotide sequence ID" value="XM_018179993.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CTE5"/>
    <dbReference type="GeneID" id="28763479"/>
    <dbReference type="InParanoid" id="A0A177CTE5"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG10182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="130" mass="14173" checksum="4630AE99B1337241" modified="2016-09-07" version="1">MNRRLQSISSIPSTASCNGDMRATGHVRPSRGGTWTNYAASVGSRKDATAGKERRGECPAIKRARRRWISRLHESNPGVRQRMEFGHGQASMPADLPHEPGFRASALSEWVCSGCARITAPVHRVAHPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CTI2</accession>
    <name>A0A177CTI2_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SWR1-complex protein 3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1161437</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040866.1">
        <property type="nucleotide sequence ID" value="XM_018177738.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CTI2"/>
    <dbReference type="STRING" id="1460663.A0A177CTI2"/>
    <dbReference type="GeneID" id="28761224"/>
    <dbReference type="InParanoid" id="A0A177CTI2"/>
    <dbReference type="OrthoDB" id="5338195at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000812">
        <property type="term" value="C:Swr1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140849">
        <property type="term" value="F:ATP-dependent H2AZ histone chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037651">
        <property type="entry name" value="Swc3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057558">
        <property type="entry name" value="Swc3_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28108">
        <property type="entry name" value="SWR1-COMPLEX PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28108:SF1">
        <property type="entry name" value="SWR1-COMPLEX PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24707">
        <property type="entry name" value="Swc3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SWR1-complex protein 3" evidence="2">
        <location>
            <begin position="70"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="287"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="457"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="610"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="301"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="344"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="378"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="457"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="475"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="495"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="509"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="527"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="610"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="653"/>
            <end position="663"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG10501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="663" mass="72371" checksum="CB456C075D682B3F" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CTI9</accession>
    <name>A0A177CTI9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1161686</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041208.1">
        <property type="nucleotide sequence ID" value="XM_018177804.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CTI9"/>
    <dbReference type="GeneID" id="28761290"/>
    <dbReference type="InParanoid" id="A0A177CTI9"/>
    <dbReference type="OrthoDB" id="3781022at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008058585" evidence="1">
        <location>
            <begin position="18"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG10843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="66" mass="6889" checksum="D6555F2D94C4A439" modified="2016-09-07" version="1">MKFFAIIAIAFASVAVACKDDNIFCAPGMGACNAPDANCAKKRSPFTVARAILHADAEAQINADTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CTK9</accession>
    <name>A0A177CTK9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative 2OG-Fe(II) oxygenase family oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CC84DRAFT_1138358</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040482.1">
        <property type="nucleotide sequence ID" value="XM_018176191.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CTK9"/>
    <dbReference type="STRING" id="1460663.A0A177CTK9"/>
    <dbReference type="GeneID" id="28759677"/>
    <dbReference type="InParanoid" id="A0A177CTK9"/>
    <dbReference type="OrthoDB" id="288590at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044283">
        <property type="term" value="P:small molecule biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.330:FF:000152">
        <property type="entry name" value="Oxidoreductase, 2OG-Fe(II) oxygenase family, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050231">
        <property type="entry name" value="Iron_ascorbate_oxido_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47990">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="4">
        <location>
            <begin position="185"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="336"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAG10117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="372" mass="41350" checksum="F149DB593B0DC022" modified="2016-09-07" version="1">MAPQIDAPKTVEWQGKRVPVWSMRTVDYGLLLSQDPAEVDNVLKACLEDGYFYLDLNNIDGRRMLGDQQETLKLMHRFFESPIEQKNEFGLISSHLGYEPQGSRTGAFGAGTKDGYEMLKVSRDEIQRGSPKVPSPIKNSGDLGILENSIGSCNTITKVILSALSTGMGLVGASRYENHHRNDKPSTTTLSMMHYLPSEITGPKEVGHQKHTDISSLTLLFSEQWGLQIRPPGTCGAREMGFVEPKKGCAFVHVGDSLRFASGMKMQSCIHRVVPFDPKEHRYSIAYFLRAEDDTMFMDSEGRYVTAGQWHDQKFKAFTDPWMYQLQAPKTMILGGMTEDGEDDPLQQEIEPASEPSPVGAKAQLASVSVHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CTP1</accession>
    <name>A0A177CTP1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">p-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1161540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041011.1">
        <property type="nucleotide sequence ID" value="XM_018177767.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CTP1"/>
    <dbReference type="STRING" id="1460663.A0A177CTP1"/>
    <dbReference type="GeneID" id="28761253"/>
    <dbReference type="InParanoid" id="A0A177CTP1"/>
    <dbReference type="OrthoDB" id="2115716at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990275">
        <property type="term" value="F:preribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19481">
        <property type="entry name" value="RecA-like_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002838">
        <property type="entry name" value="Uncharacterized ATPase YjoB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050168">
        <property type="entry name" value="AAA_ATPase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077">
        <property type="entry name" value="AAA-FAMILY ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077:SF132">
        <property type="entry name" value="ATP-DEPENDENT ZN PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATPase AAA-type core" evidence="1">
        <location>
            <begin position="228"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG10646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="540" mass="61556" checksum="CD2B394F90ABB07D" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2023-06-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CTU9</accession>
    <name>A0A177CTU9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_491027</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040996.1">
        <property type="nucleotide sequence ID" value="XM_018186492.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CTU9"/>
    <dbReference type="GeneID" id="28769978"/>
    <dbReference type="InParanoid" id="A0A177CTU9"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG10631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="76" mass="8322" checksum="FB7C8EF41461BA7C" modified="2016-09-07" version="1">MRRLPRGIAPSQGLSDLAIFLSATNAPTILGCANFEISHSLQKPRPFLTSSKCSVPLHGMMKINLVEHRFVESSNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CUF0</accession>
    <name>A0A177CUF0_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Arb2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1112890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040875.1">
        <property type="nucleotide sequence ID" value="XM_018175333.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CUF0"/>
    <dbReference type="STRING" id="1460663.A0A177CUF0"/>
    <dbReference type="GeneID" id="28758819"/>
    <dbReference type="InParanoid" id="A0A177CUF0"/>
    <dbReference type="OrthoDB" id="421951at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035197">
        <property type="term" value="F:siRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031048">
        <property type="term" value="P:regulatory ncRNA-mediated heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048263">
        <property type="entry name" value="Arb2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053858">
        <property type="entry name" value="Arb2_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21357">
        <property type="entry name" value="FAM172 FAMILY PROTEIN HOMOLOG CG10038"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21357:SF4">
        <property type="entry name" value="FAM172 FAMILY PROTEIN HOMOLOG CG10038"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22749">
        <property type="entry name" value="Arb2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arb2" evidence="1">
        <location>
            <begin position="15"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF22749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG10510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="587" mass="65637" checksum="0BC22C171DB4B1FF" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CV37</accession>
    <name>A0A177CV37_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">mRNA stability protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_1081773</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Plays an essential role in initiation of the G0 program by preventing the degradation of specific nutrient-regulated mRNAs via the 5'-3' mRNA decay pathway.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the endosulfine family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG11106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041471.1">
        <property type="nucleotide sequence ID" value="XM_018173946.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CV37"/>
    <dbReference type="STRING" id="1460663.A0A177CV37"/>
    <dbReference type="GeneID" id="28757432"/>
    <dbReference type="InParanoid" id="A0A177CV37"/>
    <dbReference type="OrthoDB" id="5949865at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006760">
        <property type="entry name" value="Endosulphine"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04667">
        <property type="entry name" value="Endosulfine"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="53"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="53"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="74"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="98"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU363120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAG11106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="111" mass="12416" checksum="516C8E8B8641F807" modified="2016-09-07" version="1" fragment="single">TERDSCLSRLYGKHPARGNLLHRQLEGRKYFDLGDYALSQASTASDIGRMRTGTEHRLRESVSHPSSPAPSGRNIKDVFTKPGEAVKERHEPKEASKLHQQMSMDKSGNAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CW71</accession>
    <name>A0A177CW71_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ribonuclease H-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1210819</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG11142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041507.1">
        <property type="nucleotide sequence ID" value="XM_018182319.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CW71"/>
    <dbReference type="STRING" id="1460663.A0A177CW71"/>
    <dbReference type="GeneID" id="28765805"/>
    <dbReference type="InParanoid" id="A0A177CW71"/>
    <dbReference type="OrthoDB" id="10252740at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003165">
        <property type="entry name" value="Piwi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22891">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02171">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00950">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50822">
        <property type="entry name" value="PIWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Piwi" evidence="1">
        <location>
            <begin position="1"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG11142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="203" mass="23339" checksum="45071D51134FACFC" modified="2016-09-07" version="1">MAYLDRNSEAIAQENMKPMTQQRLNAFYKKSNRLLANVLFYSDGIDESQYARVQVTEVLGIKSGYQAFAESTGISQDPKITTVIVTRRHHTRFYPSNVINGHENSRESNCSPGTCVDSGVTHPNYFEFYLQSHHPIKATARPARYFVLDNGMSLTEQQLQKFMYELCYSYVRATLPVGYAPPAYYADRLCERARCYFAYFLKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CWH9</accession>
    <name>A0A177CWH9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative chaperone/heat shock protein Hsp12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1253699</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG11177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041542.1">
        <property type="nucleotide sequence ID" value="XM_018184390.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CWH9"/>
    <dbReference type="STRING" id="1460663.A0A177CWH9"/>
    <dbReference type="GeneID" id="28767876"/>
    <dbReference type="InParanoid" id="A0A177CWH9"/>
    <dbReference type="OrthoDB" id="2348401at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.280.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007250">
        <property type="entry name" value="HSP9_HSP12"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04119">
        <property type="entry name" value="HSP9_HSP12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0346">Stress response</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG11177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="89" mass="9542" checksum="7849868626E4D1C1" modified="2016-09-07" version="1">MSDAGRKDFHTKLGEGLTPDSTKSTQQKMKETVTDTGDKFARGVQPDHEKSLGQEATDKVGRSHDRTAHGSSGGSILDKGKHALGLDKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CWI6</accession>
    <name>A0A177CWI6_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_1254014</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG11571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041936.1">
        <property type="nucleotide sequence ID" value="XM_018184430.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CWI6"/>
    <dbReference type="STRING" id="1460663.A0A177CWI6"/>
    <dbReference type="GeneID" id="28767916"/>
    <dbReference type="InParanoid" id="A0A177CWI6"/>
    <dbReference type="OrthoDB" id="4682787at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF47">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="29"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="162"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="206"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="248"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="282"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="107"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAG11571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="392" mass="44166" checksum="EA372AE3224CD497" modified="2016-09-07" version="1">MPVMDLNGPVASPPAGLDSNFNNPQNEAALAYTTLALSLATVTLFCWFRFLVKYCIMGKLHLEDCKFNSTSLGMPAARNAHLRIEINRIQVAAIVHIACGFQISQFAPIIHSWDMTMLTFGKYLLWYRVSSIFYNIAIVLIKVAMLIQVLRIFVPRGSQSKTYYVVHGLIWMNLLYYVIIVFLMLFNCQPFEKAWKPWLSGKCMQIGIIAMSTAVVNLIGDLSILFLTQNVIWNLMRVERRQRLKLSLVFMAGIVPCGFAVMCLYYNDKQMHSTDFTRDSMYMSIACYGEIASGMFVMFLPVVPKFFTHLKTASSFSLLSNKRTLVSEDAGTRGGVEQKKKSLFHISYTQKESEEKLGLSINVTSTVSVRREMAVGHGGGGGIEMVREREGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CWJ3</accession>
    <name>A0A177CWJ3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Velvet domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_1068987</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG11883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042248.1">
        <property type="nucleotide sequence ID" value="XM_018173655.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CWJ3"/>
    <dbReference type="STRING" id="1460663.A0A177CWJ3"/>
    <dbReference type="GeneID" id="28757141"/>
    <dbReference type="InParanoid" id="A0A177CWJ3"/>
    <dbReference type="OrthoDB" id="5599552at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3960">
        <property type="entry name" value="Velvet domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021740">
        <property type="entry name" value="Velvet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037525">
        <property type="entry name" value="Velvet_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038491">
        <property type="entry name" value="Velvet_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33572">
        <property type="entry name" value="SPORE DEVELOPMENT REGULATOR VOSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33572:SF18">
        <property type="entry name" value="SPORE DEVELOPMENT REGULATOR VOSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11754">
        <property type="entry name" value="Velvet"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51821">
        <property type="entry name" value="VELVET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0749">Sporulation</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Velvet" evidence="7">
        <location>
            <begin position="1"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="176"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="186"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAG11883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="216" mass="24137" checksum="B9BD3A363B189E46" modified="2016-09-07" version="1" fragment="single">LVIRQEPKEALVLSSGKEKGRKPVDPPPIVQLKVNSDVEASQHFLQSPYLFMVADLWKADRDERCGDHGASNLYGGLCSSLHRLKDVDNKDGAFFIFGDISVKLTGTFRLHFSLYDLQTSEHAAVFLGSIATQPFKVMAPKDFQGLEESTYLSRAFSDQGVRLRLRKEPRAFAGQKRSYFADGMPPSQSNVPGRSSSSFYEDEAPPAKRYRADTED</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CWK7</accession>
    <name>A0A177CWK7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1173401</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG11119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041484.1">
        <property type="nucleotide sequence ID" value="XM_018180033.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CWK7"/>
    <dbReference type="GeneID" id="28763519"/>
    <dbReference type="InParanoid" id="A0A177CWK7"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG11119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="346" mass="38027" checksum="1CFF92DD28C024C1" modified="2016-09-07" version="1">MSGRMHGGGKGADSSVHRVFWLYVPHLPDRSYLNCVMSLRERLFSKAFRPILTTLVSGLLDILHVLIPQGVLCALESKSSSPRNGMHDRCSVSMQHDRVTSRSRDKQRQLHLLKAVTYGPLQAHVPIFRGVAHGKVSSPSCVASFALIYFFLVGLSTTARNVIHQLLPALAPAPQQDTIVDFDNADAEDIERGTWQWLTPWSITLGRPNARHALSVRQSYQFRFGWYSIARGRDEDATLDADYIDSLGEMGRGELASDLVGRLSRVVRAMSEEERAARQEGLRRELGVLIRPEWVGRAEETAGGADTLGALGGGAGGIPPLWADPWWTAAGSFPGAGGARPPWREV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CWS6</accession>
    <name>A0A177CWS6_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CC84DRAFT_1182776</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG11973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042338.1">
        <property type="nucleotide sequence ID" value="XM_018180646.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CWS6"/>
    <dbReference type="GeneID" id="28764132"/>
    <dbReference type="InParanoid" id="A0A177CWS6"/>
    <dbReference type="OrthoDB" id="39175at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF3">
        <property type="entry name" value="HALOTOLERANCE PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="6">
        <location>
            <begin position="292"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="54"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="80"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAG11973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="653" mass="72623" checksum="D9F803D3613933B2" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CWS9</accession>
    <name>A0A177CWS9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Apple domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_38217</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG11498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041863.1">
        <property type="nucleotide sequence ID" value="XM_018185981.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CWS9"/>
    <dbReference type="STRING" id="1460663.A0A177CWS9"/>
    <dbReference type="GeneID" id="28769467"/>
    <dbReference type="InParanoid" id="A0A177CWS9"/>
    <dbReference type="OrthoDB" id="4899074at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.4.10">
        <property type="entry name" value="Hepatocyte Growth Factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008058746" description="Apple domain-containing protein" evidence="1">
        <location>
            <begin position="17"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG11498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="396" mass="42517" checksum="8B3DA83721F8CF98" modified="2016-09-07" version="1">MKFTIATALLPVLAAAANVGTFTCRTELGSKSIKNVPTDFATKTKSIRPTITTTVTPVTTEWLRYWYVITKITTSTRVVTDSTVTDTFSTTTTLYDVATNTITSTLTATATDTSTTSSTSTTIVPTATGWKPIADTVNRNSLYKREDEAERELEHPHAIRAVTSKKVKGLAAASWPSKVHCTQYVPNKNTKTVTKTRAPTTMYSPYWQKTTKTKVLSSTSTVVPDDVSTTETYSSTSSVTTFVTTFTTETTTVSTTTTSIIPGPTLYDACTKGNNIFGSNFNAGGVGYYITNIANNGPGVASDFKIVADGASSATECCSACHAFAGCETWSFRPTSRNCFLLYHEGSTCSSQTQHPNFFFSKKGSDTGAGYVVGNGNCGFTYSANSDSSVWRVDGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CWY9</accession>
    <name>A0A177CWY9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Multiprotein-bridging factor 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CC84DRAFT_1182597</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Transcriptional coactivator that stimulates GCN4-dependent transcriptional activity by bridging the DNA-binding region of GCN4 and TBP (SPT15), thereby recruiting TBP to GCN4-bound promoters. Involved in induction of the ribosome quality control (RQC) pathway; a pathway that degrades nascent peptide chains during problematic translation. Required to prevent stalled ribosomes from frameshifting.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MBF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG11721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042086.1">
        <property type="nucleotide sequence ID" value="XM_018180640.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CWY9"/>
    <dbReference type="FunCoup" id="A0A177CWY9">
        <property type="interactions" value="746"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CWY9"/>
    <dbReference type="GeneID" id="28764126"/>
    <dbReference type="InParanoid" id="A0A177CWY9"/>
    <dbReference type="OrthoDB" id="10253401at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.260.40:FF:000030">
        <property type="entry name" value="Coactivator bridging factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013729">
        <property type="entry name" value="MBF1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10245:SF15">
        <property type="entry name" value="ENDOTHELIAL DIFFERENTIATION-RELATED FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10245">
        <property type="entry name" value="ENDOTHELIAL DIFFERENTIATION-RELATED FACTOR 1 MULTIPROTEIN BRIDGING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08523">
        <property type="entry name" value="MBF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0010">Activator</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="9">
        <location>
            <begin position="102"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="50"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAG11721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="159" mass="16887" checksum="424D50241FD5EF18" modified="2016-09-07" version="1">MSEDWDTVTKIGSRTRGGAAGPRETVVKGKSALNAAQRSGAVVATEKKFSTANAGSSGSEGQRLTKVDRSDDIIKPKTVGIVVGQAISKARSEAKNDKGTTMTQKDLATKCNSTPTIIADFERGTATPDQKLLGNMERVLNVILRGDKIGQPKFPNKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CYE6</accession>
    <name>A0A177CYE6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CC84DRAFT_1183200</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042950.1">
        <property type="nucleotide sequence ID" value="XM_018180672.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CYE6"/>
    <dbReference type="FunCoup" id="A0A177CYE6">
        <property type="interactions" value="121"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CYE6"/>
    <dbReference type="GeneID" id="28764158"/>
    <dbReference type="InParanoid" id="A0A177CYE6"/>
    <dbReference type="OrthoDB" id="191979at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22249">
        <property type="entry name" value="UDM1_RNF168_RNF169-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157:SF31">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="283"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="369"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="369"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAG12585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="417" mass="46010" checksum="018B0F740CC60360" modified="2016-09-07" version="1">MPVHIAGKVWEEGISAIPYGWTLLKLIPVVGVIYLLKLYFNGAVNTSERNMHSKVVMMTGGTSGIGAEVAKGLAARGAQIVLLTQHPLTDPFLVDYIEDLRAQTGNELITAEQVDLASLYSIRKFATKWVDNAPPRRLDMVILCANTRTPSGGSAVFTEDNLEATWGLNYMANFHLLSILSPALRAQPPDRDVRIIFGTCSSYLGGVLPVSSTPAKKGKKDTIEAVPFTPSTAYATSKLALMTFALAFQKHLSSYARPDKNPNTSRVIIVDPGWTRTPGMRRFLTLGSLWGLLVYVATWPLWWLFLKSSDQGAQTFLYAAMEAQYGRGEGGWFLKECRQMEMLKDEVKDEALQKKLWEVSEESIKILEQEGAKKRAAEKKSDEKGAAEGKETKVDTKTKTKSTTAKENGAAKQRKGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CYS3</accession>
    <name>A0A177CYS3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">UDENN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_1159984</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018043080.1">
        <property type="nucleotide sequence ID" value="XM_018177377.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CYS3"/>
    <dbReference type="STRING" id="1460663.A0A177CYS3"/>
    <dbReference type="GeneID" id="28760863"/>
    <dbReference type="InParanoid" id="A0A177CYS3"/>
    <dbReference type="OrthoDB" id="6019893at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032483">
        <property type="term" value="P:regulation of Rab protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11500">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001194">
        <property type="entry name" value="cDENN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043153">
        <property type="entry name" value="DENN_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051696">
        <property type="entry name" value="DENN_Domain_GEFs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037516">
        <property type="entry name" value="Tripartite_DENN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005113">
        <property type="entry name" value="uDENN_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12296:SF31">
        <property type="entry name" value="DENN (AEX-3) DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G11200)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12296">
        <property type="entry name" value="DENN DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02141">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03456">
        <property type="entry name" value="uDENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00799">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00800">
        <property type="entry name" value="uDENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50211">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDENN" evidence="3">
        <location>
            <begin position="81"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="687"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="796"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="551"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="10"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="687"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="699"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="846"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="859"/>
            <end position="872"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAG12715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="915" mass="103501" checksum="E3629BE044D60584" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CZP4</accession>
    <name>A0A177CZP4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Acyltransferase MbtK/IucB-like conserved domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1254652</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the lysine N-acyltransferase MbtK family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042737.1">
        <property type="nucleotide sequence ID" value="XM_018184479.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CZP4"/>
    <dbReference type="STRING" id="1460663.A0A177CZP4"/>
    <dbReference type="GeneID" id="28767965"/>
    <dbReference type="InParanoid" id="A0A177CZP4"/>
    <dbReference type="OrthoDB" id="4250781at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016410">
        <property type="term" value="F:N-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019290">
        <property type="term" value="P:siderophore biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019432">
        <property type="entry name" value="Acyltransferase_MbtK/IucB-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31438:SF7">
        <property type="entry name" value="ACYLTRANSFERASE MBTK_IUCB-LIKE CONSERVED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31438">
        <property type="entry name" value="LYSINE N-ACYLTRANSFERASE C17G9.06C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13523">
        <property type="entry name" value="Acetyltransf_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01006">
        <property type="entry name" value="AlcB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyltransferase MbtK/IucB-like conserved" evidence="2">
        <location>
            <begin position="246"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG12372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="435" mass="49184" checksum="96FDEDD67308DFED" modified="2016-09-07" version="1">MAQHSAETLVLKLPHPYLTSYDITNKAAAGQLKRFQISLSAEQSKTNGAPPPVTLHHDSLSFSDIAFLEGTSIPAKGDNSSWARARRAPYTTIAWSGDRPSVAQLWLTAYALISQHPFVENIRVLFSGNDAISLATELYATGLFHPHPRGSSTSSPHDGDLLLRSTFWQGAASPFGARPVWAPLLDAHNKPIAAEYPPFPFQTAPSTVFPALPRHTMHPVRRPKPAPGSVIYSRWIPHLQEHFTMIALDYTNDEHLRLFNIWQNDPRVAAGWNETGTLDQHREYLRKLHEDPHVVTMFAAFDDVLFAYFEVYWAMEDHMGAHFLASPYDRGRHSLVGDVRFRGPYRVSAWWSGLMHYMFLDEPRTWNLVGEPAQTSSTVLAYDFVHGFHVEKLIDLPHKRSALMMVNREKFFALSPFVWDGEKKVRPSLDALAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CZU8</accession>
    <name>A0A177CZU8_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Small ribosomal subunit protein uS5m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CC84DRAFT_1135859</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the universal ribosomal protein uS5 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018043191.1">
        <property type="nucleotide sequence ID" value="XM_018176077.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CZU8"/>
    <dbReference type="STRING" id="1460663.A0A177CZU8"/>
    <dbReference type="GeneID" id="28759563"/>
    <dbReference type="InParanoid" id="A0A177CZU8"/>
    <dbReference type="OrthoDB" id="309483at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.20:FF:000022">
        <property type="entry name" value="28S ribosomal protein S5, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000041">
        <property type="entry name" value="37S ribosomal protein S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000851">
        <property type="entry name" value="Ribosomal_uS5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005324">
        <property type="entry name" value="Ribosomal_uS5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013810">
        <property type="entry name" value="Ribosomal_uS5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48277">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOMAL PROTEIN S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48277:SF1">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOMAL PROTEIN S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00333">
        <property type="entry name" value="Ribosomal_S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03719">
        <property type="entry name" value="Ribosomal_S5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50881">
        <property type="entry name" value="S5_DSRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 8 9" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="S5 DRBM" evidence="11">
        <location>
            <begin position="263"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="21"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00039335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OAG12826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="427" mass="47983" checksum="9C03A57D2517D2C6" modified="2016-09-07" version="1">MSVCRPVRCLFASAALPKPSAAPQRSFHASAPRAARKRRPHYPSIKAEDLKLLNQAAETHYPKYDTSETALLEKRYTPAQIAAIKAAETAIDSRDLLTQSSHRTDPWLLPYEDDLAEVDPVTDHAEKLDPSDIPGSHDFQDVNEEERDEAITFIANENLAKMFPDGLPEGELSEETQRQLQEAMGTAVTQALLDPRASFRVKNRHAAAALADPRHSIVMPDLPRIENRMVRQTRRLSSEEAEDPRQKRLLQYLNWDKQKLRSIKVKTLVVHGVTNQTRMGKIRSMYYLTIAGNQAGLLGVGEGKSVEPDEGRKQSVMAAIRNMRPIPRYENRTTFGDLECKVGATKVQLFSRPPGFGLRVQHLIFEIARAAGLQDLAARTPRSRNKMNVIKATWEALCNQKLPDEIARARGKKLVDVRKVYYGGSVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177D0T5</accession>
    <name>A0A177D0T5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">14-3-3 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_180038</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG13106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018043471.1">
        <property type="nucleotide sequence ID" value="XM_018185481.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177D0T5"/>
    <dbReference type="STRING" id="1460663.A0A177D0T5"/>
    <dbReference type="GeneID" id="28768967"/>
    <dbReference type="InParanoid" id="A0A177D0T5"/>
    <dbReference type="OrthoDB" id="5370350at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.190.20">
        <property type="entry name" value="14-3-3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036815">
        <property type="entry name" value="14-3-3_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48445">
        <property type="entry name" value="14-3-3 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="315"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="349"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="394"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="412"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="446"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="477"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG13106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="517" mass="55789" checksum="026DDBFFB23C6545" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BT45</accession>
    <name>A0A177BT45_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CC84DRAFT_1210798</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441575">
        <property type="protein sequence ID" value="OAF98474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018028840.1">
        <property type="nucleotide sequence ID" value="XM_018182316.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BT45"/>
    <dbReference type="STRING" id="1460663.A0A177BT45"/>
    <dbReference type="GeneID" id="28765802"/>
    <dbReference type="InParanoid" id="A0A177BT45"/>
    <dbReference type="OrthoDB" id="6105938at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24409">
        <property type="entry name" value="ZINC FINGER PROTEIN 142"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="84"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAF98474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="233" mass="26910" checksum="3544E1B9B1BA1FF0" modified="2016-09-07" version="1">MGKTYCSRCNRDFPSPRALQQHLDDASNHYRCEVCGYDASTWDKWLKHHLKTKHRVVCQGCNDGEGSTWVAGSQEYLAHLEEENVCRTCEEHFQNPSNLNHHKMVHLDLSIECYGCYRKFTTYPAMILHLESGTCPSNIDIIELNESAAMCYQWGAYVDRDFRTELLNRDDLQSEYSGPVYPFRCPVCDVGFTKLSGLFQHVYSKSCDQGLYDGTMAKLIKWLGNRHDIDEDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BTZ9</accession>
    <name>A0A177BTZ9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1223483</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441564">
        <property type="protein sequence ID" value="OAF98734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029100.1">
        <property type="nucleotide sequence ID" value="XM_018183496.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BTZ9"/>
    <dbReference type="STRING" id="1460663.A0A177BTZ9"/>
    <dbReference type="GeneID" id="28766982"/>
    <dbReference type="InParanoid" id="A0A177BTZ9"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="95"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAF98734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="209" mass="24505" checksum="DCCAA01B88769E53" modified="2016-09-07" version="1">MCLVKVRQDEDVVVPYRVPRDRSPRRRESVRRVSRMSQEVVRESPRSSYLAVPAPRPMPIPAPQPVPVFVEPPPAPLPPPPPSLSHHSAHYVEVSPARSSRSSVSSSSMDRSEYVVRERQYRRREHSPASSSPRYEHFRYVEPPPSDSDHFERYDRRRSRSRPRERSLSRGRGDYYGRGSRDYGGERVTRERITISERERDGRRGEYRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BVU4</accession>
    <name>A0A177BVU4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_1238634</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441575">
        <property type="protein sequence ID" value="OAF98476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018028842.1">
        <property type="nucleotide sequence ID" value="XM_018183953.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BVU4"/>
    <dbReference type="STRING" id="1460663.A0A177BVU4"/>
    <dbReference type="GeneID" id="28767439"/>
    <dbReference type="InParanoid" id="A0A177BVU4"/>
    <dbReference type="OrthoDB" id="5240432at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848:SF8">
        <property type="entry name" value="F-BOX AND WD REPEAT DOMAIN CONTAINING 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="6"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAF98476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="111" mass="11562" checksum="52C23340A12B056A" modified="2016-09-07" version="1" fragment="single">ACLQTLEGHSDQLTSVAFSPDSTRLASASTDGTVKVWDAGSGACLQTLDIGYPLQTMSFNASGSGLLTNIGVINLGPLLSSNITTTTQELESPKYQVTALSSDGTWITYNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BVX2</accession>
    <name>A0A177BVX2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Beta subunit of citrate lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CC84DRAFT_1131921</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KV441563">
        <property type="protein sequence ID" value="OAF99080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029446.1">
        <property type="nucleotide sequence ID" value="XM_018175918.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BVX2"/>
    <dbReference type="STRING" id="1460663.A0A177BVX2"/>
    <dbReference type="GeneID" id="28759404"/>
    <dbReference type="InParanoid" id="A0A177BVX2"/>
    <dbReference type="OrthoDB" id="1773at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006107">
        <property type="term" value="P:oxaloacetate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.60:FF:000023">
        <property type="entry name" value="CitE, Citrate lyase beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005000">
        <property type="entry name" value="Aldolase/citrate-lyase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011206">
        <property type="entry name" value="Citrate_lyase_beta/mcl1/mcl2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32308:SF0">
        <property type="entry name" value="HPCH_HPAI ALDOLASE_CITRATE LYASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32308">
        <property type="entry name" value="LYASE BETA SUBUNIT, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G13030)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03328">
        <property type="entry name" value="HpcH_HpaI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015582">
        <property type="entry name" value="Cit_lyase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HpcH/HpaI aldolase/citrate lyase" evidence="6">
        <location>
            <begin position="10"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR015582-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR015582-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAF99080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="323" mass="35377" checksum="0ABB6A40ED2136D4" modified="2016-09-07" version="1">MATSRNIIRRALMYVPGSSKKMLDKTASMRVDTVAYDLEDSVAPHMKQEARRNLVSILSKPRPSTIKEMCVRINSVDTGLALDDLSSVLKGEHLDAIMLPKCESAADLHFVTDVIRHVLPERHPADGVQREGARPPISIIALIESAKSIQNLAEICKASPYLSGLVFAAEDFAKDMSITRTPSLTEFLYARSAIATHARAAGLPSTIDLVCTAYKGPEGLKTLEEECLNGKGMGFNGKQCIHPSQIEVCQRAFAPGEAEVDWSARVVIADEKASKAGRGAWTLEGKMIDVPVVKKARAVLERAELCEINVDAVRERWKNQEPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BWE1</accession>
    <name>A0A177BWE1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1169546</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441562">
        <property type="protein sequence ID" value="OAF99445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029811.1">
        <property type="nucleotide sequence ID" value="XM_018179687.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BWE1"/>
    <dbReference type="STRING" id="1460663.A0A177BWE1"/>
    <dbReference type="GeneID" id="28763173"/>
    <dbReference type="InParanoid" id="A0A177BWE1"/>
    <dbReference type="OrthoDB" id="4338954at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAF99445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="187" mass="20436" checksum="FB597B6315C8E2AD" modified="2016-09-07" version="1">MSPRAPSTMARRFIATATHQPAPAFNASRAAVPLIAAGAAATAATAVTASRAAPKLGRIAKWYLPTMAAVAFGMLYIPETFFIEPSKRTVTLDQANRFIGMGVDQQLSDHNRRANVGYELTQEERNQAMLDSFGSRSSLDDMEKAIAGYEATRPKGPVETRMALENAYGDRSSLQHLRRAMQIYEVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BWJ9</accession>
    <name>A0A177BWJ9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Beta-lactamase/transpeptidase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_1181628</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-A beta-lactamase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441563">
        <property type="protein sequence ID" value="OAF98877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029243.1">
        <property type="nucleotide sequence ID" value="XM_018180565.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BWJ9"/>
    <dbReference type="STRING" id="1460663.A0A177BWJ9"/>
    <dbReference type="GeneID" id="28764051"/>
    <dbReference type="InParanoid" id="A0A177BWJ9"/>
    <dbReference type="OrthoDB" id="428260at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="entry name" value="DD-peptidase/beta-lactamase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050789">
        <property type="entry name" value="Diverse_Enzym_Activities"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43283:SF17">
        <property type="entry name" value="(LOVD), PUTATIVE (AFU_ORTHOLOGUE AFUA_5G00920)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43283">
        <property type="entry name" value="BETA-LACTAMASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="beta-lactamase/transpeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase-related" evidence="3">
        <location>
            <begin position="1"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAF98877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="217" mass="24179" checksum="833F481CFC1B90A0" modified="2016-09-07" version="1">MTKLLTAVACMQAVEAGIVRLDEPISKILPEVGKYGILTRFDDEKNESVYMQQKTPVTLRPLLAKWGASRGELPWTGPTVEHKATLPLLFEPSTSFRYSGGFDWAGNLMERFTRNTFEQFMIEGIFEPLGIKNITFYPDRRPGVSNHLATVSMLSETGEGLAAHAATFDPLFGGKDCLDCGGAYVSASDYFKFLHAVPRRDSRMLKPESYDELSRLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BXT7</accession>
    <name>A0A177BXT7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Integral membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CC84DRAFT_1223009</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM170 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441562">
        <property type="protein sequence ID" value="OAF99327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029693.1">
        <property type="nucleotide sequence ID" value="XM_018183453.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BXT7"/>
    <dbReference type="FunCoup" id="A0A177BXT7">
        <property type="interactions" value="4"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177BXT7"/>
    <dbReference type="GeneID" id="28766939"/>
    <dbReference type="InParanoid" id="A0A177BXT7"/>
    <dbReference type="OrthoDB" id="2131401at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019334">
        <property type="entry name" value="TMEM170A/B/YPR153W-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22779">
        <property type="entry name" value="SD17342P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22779:SF6">
        <property type="entry name" value="SD17342P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10190">
        <property type="entry name" value="Tmemb_170"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="43"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="81"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAF99327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="141" mass="15663" checksum="AAF2969E0406A7B3" modified="2016-09-07" version="1">MSFITRTGSTAPAGYKAPPWPSLYWPLPVSASVPYYLYDPDDIWRFTLIWTALFFGAMHLVVAFWACIVQWRNWKIIWITPLLYAIIGGLEGLIAGSIVGGLLGGVYQSGYFKMSTWIPFVWGLISAVVLVLSSFAIHGGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BXX4</accession>
    <name>A0A177BXX4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_1130312</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441561">
        <property type="protein sequence ID" value="OAF99551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029917.1">
        <property type="nucleotide sequence ID" value="XM_018175856.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BXX4"/>
    <dbReference type="STRING" id="1460663.A0A177BXX4"/>
    <dbReference type="GeneID" id="28759342"/>
    <dbReference type="InParanoid" id="A0A177BXX4"/>
    <dbReference type="OrthoDB" id="5598057at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd13311">
        <property type="entry name" value="PH_Slm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046868">
        <property type="entry name" value="BAR_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046869">
        <property type="entry name" value="SLM1/RGC1-like_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043453">
        <property type="entry name" value="Slm1_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31941">
        <property type="entry name" value="CYTOSKELETAL SIGNALING PROTEIN SLM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31941:SF16">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE-BINDING PROTEIN SLM1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20400">
        <property type="entry name" value="BAR_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20399">
        <property type="entry name" value="PH_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="3">
        <location>
            <begin position="438"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="78"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="554"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="648"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="789"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="941"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="107"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="560"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="586"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="677"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="731"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="819"/>
            <end position="828"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAF99551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="963" mass="103584" checksum="BAFAF3F578DB5C7D" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BYW3</accession>
    <name>A0A177BYW3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1222635</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441561">
        <property type="protein sequence ID" value="OAF99616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029982.1">
        <property type="nucleotide sequence ID" value="XM_018183399.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BYW3"/>
    <dbReference type="GeneID" id="28766885"/>
    <dbReference type="InParanoid" id="A0A177BYW3"/>
    <dbReference type="OrthoDB" id="3798938at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="32"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="205"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAF99616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="308" mass="33372" checksum="07D75CADAB452EA7" modified="2016-09-07" version="1">MDTPAITPEILAQPGDSPSTGPSPPHESATPQSQSQSQQAQAHSHILRHQQTQQPKTQGTTTMDSTFFFGKSLRPLSPPESPFAFDAAFSAKPQQTSPPSSTGGLQTSAPASPHFTLPALVRPTYLSLAKPPTPNLSTARTKRERGWAKAVVPQRTADNPYFPSIAEQERAEKWVRDQARFTLPEPSPPAMVEHSGVVGGADPFSHANSASSASASSGATASSPGEKSGPRFKLDLGDVRRRRALRVCAEVPASPESLENGIAGRRASEDEEAYKKQMAKHLAERIRRRSVRPEPWGRRDGEEGRFEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BZ13</accession>
    <name>A0A177BZ13_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1168688</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441559">
        <property type="protein sequence ID" value="OAG00613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030978.1">
        <property type="nucleotide sequence ID" value="XM_018179457.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BZ13"/>
    <dbReference type="GeneID" id="28762943"/>
    <dbReference type="InParanoid" id="A0A177BZ13"/>
    <dbReference type="OrthoDB" id="7984201at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="166"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG00613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="579" mass="66544" checksum="DEDA1AF5907C07C0" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BZB6</accession>
    <name>A0A177BZB6_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">SP-RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CC84DRAFT_1154213</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441558">
        <property type="protein sequence ID" value="OAG00874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031239.1">
        <property type="nucleotide sequence ID" value="XM_018176873.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BZB6"/>
    <dbReference type="STRING" id="1460663.A0A177BZB6"/>
    <dbReference type="GeneID" id="28760359"/>
    <dbReference type="InParanoid" id="A0A177BZB6"/>
    <dbReference type="OrthoDB" id="27975at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061665">
        <property type="term" value="F:SUMO ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016925">
        <property type="term" value="P:protein sumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16650">
        <property type="entry name" value="SP-RING_PIAS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004181">
        <property type="entry name" value="Znf_MIZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10782:SF4">
        <property type="entry name" value="TONALLI, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10782">
        <property type="entry name" value="ZINC FINGER MIZ DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02891">
        <property type="entry name" value="zf-MIZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51044">
        <property type="entry name" value="ZF_SP_RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SP-RING-type" evidence="6">
        <location>
            <begin position="829"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="29"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="164"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="540"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="937"/>
            <end position="986"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="90"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="215"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="540"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="937"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="956"/>
            <end position="975"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAG00874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="986" mass="111119" checksum="16B1C7239ABD7B07" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BZC5</accession>
    <name>A0A177BZC5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1168104</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441558">
        <property type="protein sequence ID" value="OAG00884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031249.1">
        <property type="nucleotide sequence ID" value="XM_018179319.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BZC5"/>
    <dbReference type="STRING" id="1460663.A0A177BZC5"/>
    <dbReference type="GeneID" id="28762805"/>
    <dbReference type="InParanoid" id="A0A177BZC5"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051468">
        <property type="entry name" value="Fungal_SecMetab_SDRs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43544:SF32">
        <property type="entry name" value="CHAIN DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G01530)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43544">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG00884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="246" mass="26061" checksum="B978CEC4A0ADE650" modified="2016-09-07" version="1">MAINKTITLITGANGGIGFELAAQLLGDASKHVLLGSRSFEKGEAAVKELQTRNLPGSVELVQIDVTNEDSINAAVKEVEVKHGRLDALVNNAAIADAPGTSFRKLNEVFRTNVAGPYATVEAFAPLLEKSTRTPRIVNVSSGGGSIGLRLDPSNAFYTLKGDQYRVSKAGLNMVNACQAVEYGPKGWKVFSFCPGFTVSNLGPHNKVENGAKPTSEGAGPMVGILNGERDSEHGLLLKADGQWPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2023-06-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BZD8</accession>
    <name>A0A177BZD8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_359324</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441560">
        <property type="protein sequence ID" value="OAG00079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030444.1">
        <property type="nucleotide sequence ID" value="XM_018185896.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BZD8"/>
    <dbReference type="GeneID" id="28769382"/>
    <dbReference type="InParanoid" id="A0A177BZD8"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG00079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="151" mass="17071" checksum="2DAE899E00941F72" modified="2016-09-07" version="1">MSDSMHEAVQLLLLMDDVLGKGTGLIPVWYCLAQRPKQNFLFAHYAKACPLSNLASYYIVNLKQVSECEQPFLSCFAVFFFQPFTVTHSALPRHTISESTRTSRLLLGFSGPKSLLTTIFLVLPTCRRIRSRIRNSFFGSHFLPVNSPLVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BZN0</accession>
    <name>A0A177BZN0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_333023</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441560">
        <property type="protein sequence ID" value="OAF99896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030262.1">
        <property type="nucleotide sequence ID" value="XM_018185863.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BZN0"/>
    <dbReference type="GeneID" id="28769349"/>
    <dbReference type="InParanoid" id="A0A177BZN0"/>
    <dbReference type="OrthoDB" id="1523883at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.270">
        <property type="entry name" value="Methyltransferase, alpha-helical capping domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005299">
        <property type="entry name" value="MeTrfase_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042086">
        <property type="entry name" value="MeTrfase_capping"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31009">
        <property type="entry name" value="S-ADENOSYL-L-METHIONINE:CARBOXYL METHYLTRANSFERASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03492">
        <property type="entry name" value="Methyltransf_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAF99896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="383" mass="43585" checksum="08869BF48CE93158" modified="2016-09-07" version="1">MSSLVSHLDLIVPPEKATHTHSTGPDTTSNAGTFAYATNSAFQRSIYQKCEPYVPDLKGLKTITVVDYGCGPGRNWTYGLNLLLSRADEDIQYQLVLNDGMKTDWKEVAQVVQDYRAGQCGRQIGHFAVLPGTFYDQIMPDRTVDIGMAWSSFHWLERTPPPMDIQPNEDYYTAWQANIRSQGLEDLTKLLCLRAREIKPGGHLLVVIPTTPASSVKVYWEAFLEAFKRCLKDGTITPEQWRAFRAPFFQPTEDDLRQILTTVRDLWHLPIPWAYHTLAHPAWKTLQDSEKTQQDYEEYVDGIAGFFMALIRDVLVRALRGGEGINLECPAANEQSILQQVTTRFREAVLSEELRNKRPESCWLAMRLVRKHGVNILEAKANL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C0H0</accession>
    <name>A0A177C0H0_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CC84DRAFT_1101589</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="KV441558">
        <property type="protein sequence ID" value="OAG00906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031271.1">
        <property type="nucleotide sequence ID" value="XM_018174921.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C0H0"/>
    <dbReference type="STRING" id="1460663.A0A177C0H0"/>
    <dbReference type="ESTHER" id="9pleo-a0a177c0h0">
        <property type="family name" value="Fungal_carboxylesterase_lipase"/>
    </dbReference>
    <dbReference type="GeneID" id="28758407"/>
    <dbReference type="InParanoid" id="A0A177C0H0"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050654">
        <property type="entry name" value="AChE-related_enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918">
        <property type="entry name" value="ACETYLCHOLINESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918:SF4">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="24"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAG00906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="533" mass="57929" checksum="4971645AD293D2D4" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C0Y7</accession>
    <name>A0A177C0Y7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Protein PNS1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CC84DRAFT_185844</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 8">Probably involved in transport through the plasma membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 8">Cell membrane</location>
            <topology evidence="2 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the CTL (choline transporter-like) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441557">
        <property type="protein sequence ID" value="OAG01303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031668.1">
        <property type="nucleotide sequence ID" value="XM_018185511.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C0Y7"/>
    <dbReference type="FunCoup" id="A0A177C0Y7">
        <property type="interactions" value="249"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177C0Y7"/>
    <dbReference type="GeneID" id="28768997"/>
    <dbReference type="InParanoid" id="A0A177C0Y7"/>
    <dbReference type="OrthoDB" id="44736at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007603">
        <property type="entry name" value="Choline_transptr-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12385">
        <property type="entry name" value="CHOLINE TRANSPORTER-LIKE (SLC FAMILY 44)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12385:SF4">
        <property type="entry name" value="PROTEIN PNS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04515">
        <property type="entry name" value="Choline_transpo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="77"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="153"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="177"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="220"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="262"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="323"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="361"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="418"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="459"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="21"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU368066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAG01303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="525" mass="58031" checksum="08C9B7DB6BDEBC10" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C1M4</accession>
    <name>A0A177C1M4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Carnitine O-acetyltransferase, mitochondrial</fullName>
            <ecNumber evidence="16">2.3.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">CC84DRAFT_1190275</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Carnitine acetylase is specific for short chain fatty acids. Carnitine acetylase seems to affect the flux through the pyruvate dehydrogenase complex. It may be involved as well in the transport of acetyl-CoA into mitochondria.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>(R)-carnitine + acetyl-CoA = O-acetyl-(R)-carnitine + CoA</text>
            <dbReference type="Rhea" id="RHEA:21136"/>
            <dbReference type="ChEBI" id="CHEBI:16347"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57589"/>
            <dbReference type="EC" id="2.3.1.7"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Matrix side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 19">Belongs to the carnitine/choline acetyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.7" evidence="16"/>
    <dbReference type="EMBL" id="KV441558">
        <property type="protein sequence ID" value="OAG01111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031476.1">
        <property type="nucleotide sequence ID" value="XM_018181107.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C1M4"/>
    <dbReference type="FunCoup" id="A0A177C1M4">
        <property type="interactions" value="186"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177C1M4"/>
    <dbReference type="GeneID" id="28764593"/>
    <dbReference type="InParanoid" id="A0A177C1M4"/>
    <dbReference type="OrthoDB" id="240216at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004092">
        <property type="term" value="F:carnitine O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009437">
        <property type="term" value="P:carnitine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.70:FF:000007">
        <property type="entry name" value="Carnitine O-acetyltransferase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.70">
        <property type="entry name" value="Choline/Carnitine o-acyltransferase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000542">
        <property type="entry name" value="Carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039551">
        <property type="entry name" value="Cho/carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042231">
        <property type="entry name" value="Cho/carn_acyl_trans_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589:SF103">
        <property type="entry name" value="CARNITINE O-ACETYL-TRANSFERASE, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589">
        <property type="entry name" value="CARNITINE O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00755">
        <property type="entry name" value="Carn_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00439">
        <property type="entry name" value="ACYLTRANSF_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00440">
        <property type="entry name" value="ACYLTRANSF_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 19 22" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 19 22" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Choline/carnitine acyltransferase" evidence="21">
        <location>
            <begin position="36"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="18">
        <location>
            <position position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00052702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00053195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00066910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00073438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR600542-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU003801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF00755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="OAG01111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="611" mass="69279" checksum="487806932D8DD924" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C270</accession>
    <name>A0A177C270_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Metallopeptidase MepB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CC84DRAFT_1167752</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9">Binds 1 zinc ion.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the peptidase M3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441557">
        <property type="protein sequence ID" value="OAG01546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031911.1">
        <property type="nucleotide sequence ID" value="XM_018179254.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C270"/>
    <dbReference type="FunCoup" id="A0A177C270">
        <property type="interactions" value="733"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177C270"/>
    <dbReference type="GeneID" id="28762740"/>
    <dbReference type="InParanoid" id="A0A177C270"/>
    <dbReference type="OrthoDB" id="534666at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006518">
        <property type="term" value="P:peptide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06455">
        <property type="entry name" value="M3A_TOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.40:FF:000001">
        <property type="entry name" value="Thimet oligopeptidase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.390.10:FF:000006">
        <property type="entry name" value="Thimet oligopeptidase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.40">
        <property type="entry name" value="Endopeptidase. Chain P, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1370.10">
        <property type="entry name" value="Neurolysin, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024077">
        <property type="entry name" value="Neurolysin/TOP_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024080">
        <property type="entry name" value="Neurolysin/TOP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045090">
        <property type="entry name" value="Pept_M3A_M3B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001567">
        <property type="entry name" value="Pept_M3A_M3B_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11804">
        <property type="entry name" value="PROTEASE M3 THIMET OLIGOPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11804:SF84">
        <property type="entry name" value="SACCHAROLYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01432">
        <property type="entry name" value="Peptidase_M3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 9" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4 9" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M3A/M3B catalytic" evidence="10">
        <location>
            <begin position="221"/>
            <end position="715"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OAG01546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="718" mass="81862" checksum="0D7F44B26DA6FA12" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C2Y1</accession>
    <name>A0A177C2Y1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Sugar transporter family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_275658</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441558">
        <property type="protein sequence ID" value="OAG01020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031385.1">
        <property type="nucleotide sequence ID" value="XM_018185707.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C2Y1"/>
    <dbReference type="FunCoup" id="A0A177C2Y1">
        <property type="interactions" value="24"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177C2Y1"/>
    <dbReference type="GeneID" id="28769193"/>
    <dbReference type="InParanoid" id="A0A177C2Y1"/>
    <dbReference type="OrthoDB" id="5296287at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015355">
        <property type="term" value="F:secondary active monocarboxylate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035879">
        <property type="term" value="P:plasma membrane lactate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17316">
        <property type="entry name" value="MFS_SV2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000190">
        <property type="entry name" value="Sugar transporter family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000276">
        <property type="entry name" value="Sugar transporter family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23508">
        <property type="entry name" value="CARBOXYLIC ACID TRANSPORTER PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23508:SF10">
        <property type="entry name" value="CARBOXYLIC ACID TRANSPORTER PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="57"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="127"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="154"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="193"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="233"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="286"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="324"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="354"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="378"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="451"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="59"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="490"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="501"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAG01020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="520" mass="57656" checksum="60D33D7EB30489E6" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C374</accession>
    <name>A0A177C374_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RmlC-like cupin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1168357</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441558">
        <property type="protein sequence ID" value="OAG01238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031603.1">
        <property type="nucleotide sequence ID" value="XM_018179376.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C374"/>
    <dbReference type="STRING" id="1460663.A0A177C374"/>
    <dbReference type="GeneID" id="28762862"/>
    <dbReference type="InParanoid" id="A0A177C374"/>
    <dbReference type="OrthoDB" id="3511549at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02210">
        <property type="entry name" value="cupin_BLR2406-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052535">
        <property type="entry name" value="Bacilysin_H2HPP_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40112">
        <property type="entry name" value="H2HPP ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40112:SF1">
        <property type="entry name" value="H2HPP ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin type-2" evidence="2">
        <location>
            <begin position="80"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG01238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="188" mass="20190" checksum="1FC7FC1C20876F12" modified="2016-09-07" version="1">MSSDQGPAPTASSHGYTHNHGHDHSHPHPAPEDAWKTTGVRVIPGDSLEPVGGAHQTPGMDRAAAINFARVGASKLWAGTVHIHAGAKTGAHHHGHLESVIYVLKGRARMRWGEKLEFTAEAGPGDFIFVPPYVPHQEINASSEEKLECVLMRSDSEAVAINLPELEPVERPETVKWIDPTHPDGAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C3A9</accession>
    <name>A0A177C3A9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">alpha-L-fucosidase</fullName>
            <ecNumber evidence="3">3.2.1.51</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CC84DRAFT_970909</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 29 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.51" evidence="3"/>
    <dbReference type="EMBL" id="KV441556">
        <property type="protein sequence ID" value="OAG01876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032241.1">
        <property type="nucleotide sequence ID" value="XM_018188013.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C3A9"/>
    <dbReference type="STRING" id="1460663.A0A177C3A9"/>
    <dbReference type="GeneID" id="28771499"/>
    <dbReference type="InParanoid" id="A0A177C3A9"/>
    <dbReference type="OrthoDB" id="6039950at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004560">
        <property type="term" value="F:alpha-L-fucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006004">
        <property type="term" value="P:fucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016139">
        <property type="term" value="P:glycoside catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.20.10">
        <property type="entry name" value="Crystallins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016286">
        <property type="entry name" value="FUC_metazoa-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031919">
        <property type="entry name" value="Fucosidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000933">
        <property type="entry name" value="Glyco_hydro_29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057739">
        <property type="entry name" value="Glyco_hydro_29_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10030">
        <property type="entry name" value="ALPHA-L-FUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10030:SF37">
        <property type="entry name" value="ALPHA-L-FUCOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01120">
        <property type="entry name" value="Alpha_L_fucos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16757">
        <property type="entry name" value="Fucosidase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00741">
        <property type="entry name" value="GLHYDRLASE29"/>
    </dbReference>
    <dbReference type="SMART" id="SM00812">
        <property type="entry name" value="Alpha_L_fucos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008057730" description="alpha-L-fucosidase" evidence="7">
        <location>
            <begin position="27"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 29 N-terminal" evidence="8">
        <location>
            <begin position="25"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-L-fucosidase C-terminal" evidence="9">
        <location>
            <begin position="427"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAG01876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="610" mass="67226" checksum="E26251681EE5AE8A" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C3U3</accession>
    <name>A0A177C3U3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Mitochondrial ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CC84DRAFT_1198679</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AFG1 ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441557">
        <property type="protein sequence ID" value="OAG01458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031823.1">
        <property type="nucleotide sequence ID" value="XM_018181582.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C3U3"/>
    <dbReference type="FunCoup" id="A0A177C3U3">
        <property type="interactions" value="815"/>
    </dbReference>
    <dbReference type="GeneID" id="28765068"/>
    <dbReference type="InParanoid" id="A0A177C3U3"/>
    <dbReference type="OrthoDB" id="548867at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141164">
        <property type="term" value="P:mitochondrial protein quality control"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005654">
        <property type="entry name" value="ATPase_AFG1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF040713">
        <property type="entry name" value="ZapE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12169:SF6">
        <property type="entry name" value="AFG1-LIKE ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12169">
        <property type="entry name" value="ATPASE N2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03969">
        <property type="entry name" value="AFG1_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="540"/>
            <end position="563"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAG01458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="563" mass="63494" checksum="037998814CAA65FD" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2023-06-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C448</accession>
    <name>A0A177C448_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_200283</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441557">
        <property type="protein sequence ID" value="OAG01497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031862.1">
        <property type="nucleotide sequence ID" value="XM_018185560.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C448"/>
    <dbReference type="GeneID" id="28769046"/>
    <dbReference type="InParanoid" id="A0A177C448"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG01497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="137" mass="14836" checksum="389DCC14D815EC3C" modified="2016-09-07" version="1">MKPSPTAFNAPLLGPVACTQVCYSQDGKGLPTYKTDVGAVETAIRVVHRTGRSQQSKMSAACAKSLQIREGVMVSYQYHACSVENASIPPVAFRVRHASSHETIYKILELYNRPSGHYIVVSSSSKCIHSSHSAIAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C4M9</accession>
    <name>A0A177C4M9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CRAL/TRIO domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1124555</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG02694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033059.1">
        <property type="nucleotide sequence ID" value="XM_018175696.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C4M9"/>
    <dbReference type="STRING" id="1460663.A0A177C4M9"/>
    <dbReference type="GeneID" id="28759182"/>
    <dbReference type="InParanoid" id="A0A177C4M9"/>
    <dbReference type="OrthoDB" id="30289at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.20">
        <property type="entry name" value="N-terminal domain of phosphatidylinositol transfer protein sec14p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011074">
        <property type="entry name" value="CRAL/TRIO_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051026">
        <property type="entry name" value="PI/PC_transfer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45657">
        <property type="entry name" value="CRAL-TRIO DOMAIN-CONTAINING PROTEIN YKL091C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45657:SF3">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G09260)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03765">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01100">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="2">
        <location>
            <begin position="100"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="384"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="518"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="394"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="531"/>
            <end position="569"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG02694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="569" mass="62228" checksum="0288B04F0213EF8C" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C5B5</accession>
    <name>A0A177C5B5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1152265</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441556">
        <property type="protein sequence ID" value="OAG02079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032444.1">
        <property type="nucleotide sequence ID" value="XM_018176796.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C5B5"/>
    <dbReference type="STRING" id="1460663.A0A177C5B5"/>
    <dbReference type="GeneID" id="28760282"/>
    <dbReference type="InParanoid" id="A0A177C5B5"/>
    <dbReference type="OrthoDB" id="5840532at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASES/REDUCTASES FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG02079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="264" mass="28427" checksum="DFC9202C5616C85C" modified="2016-09-07" version="1">MAFSLKGVAYITGAGSGIGQYAAYAMARQGVRSFALLDRNPVTTTVQQLKKDYPDISIKEFEIDVADEAAVNDSVEQTVKEFGRLDYALNNAGIGGALNTTDQIEKSDFERVMSINTTGVWLCQRAQIRQMLKQDKRSDSYRSYRGSIVNTASMYGLVGPTLNVPATAYATSKHAVVGLTKADAIAMAPRGIKINAICPGYVLTPLVESTMNKGSVMDDERVKVPVQRFASMEEIGDVIAFLHSDASSYVVGSALVADGGFTIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C5F2</accession>
    <name>A0A177C5F2_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CC84DRAFT_1150965</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG02843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033208.1">
        <property type="nucleotide sequence ID" value="XM_018176721.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A177C5F2">
        <property type="interactions" value="939"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177C5F2"/>
    <dbReference type="GeneID" id="28760207"/>
    <dbReference type="InParanoid" id="A0A177C5F2"/>
    <dbReference type="OrthoDB" id="5600252at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd17917">
        <property type="entry name" value="DEXHc_RHA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23827">
        <property type="entry name" value="RWD_YLR419W-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001214">
        <property type="entry name" value="DExH-box ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056328">
        <property type="entry name" value="DSRM_DHX29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059023">
        <property type="entry name" value="RNA_hel_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006575">
        <property type="entry name" value="RWD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF267">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE YLR419W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24385">
        <property type="entry name" value="DSRM_DHX29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26026">
        <property type="entry name" value="RNA_hel_CTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05773">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00591">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50908">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RWD" evidence="8">
        <location>
            <begin position="439"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="619"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="803"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="550"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="427"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="48"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="554"/>
            <end position="564"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OAG02843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="1359" mass="151362" checksum="4C6BA881CE3BC619" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C5I3</accession>
    <name>A0A177C5I3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">C4-dicarboxylate transporter/malic acid transport protein-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CC84DRAFT_1189458</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441556">
        <property type="protein sequence ID" value="OAG02149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032514.1">
        <property type="nucleotide sequence ID" value="XM_018181057.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C5I3"/>
    <dbReference type="STRING" id="1460663.A0A177C5I3"/>
    <dbReference type="GeneID" id="28764543"/>
    <dbReference type="InParanoid" id="A0A177C5I3"/>
    <dbReference type="OrthoDB" id="2901184at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015140">
        <property type="term" value="F:malate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09317">
        <property type="entry name" value="TDT_Mae1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.150">
        <property type="entry name" value="Voltage-dependent anion channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030185">
        <property type="entry name" value="Mae1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004695">
        <property type="entry name" value="SLAC1/Mae1/Ssu1/TehA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038665">
        <property type="entry name" value="Voltage-dep_anion_channel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31162:SF0">
        <property type="entry name" value="MALIC ACID TRANSPORT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31162">
        <property type="entry name" value="MALIC ACID TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03595">
        <property type="entry name" value="SLAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="183"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="222"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="263"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="303"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="336"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAG02149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="384" mass="43091" checksum="809738AF84CB45F1" modified="2016-09-07" version="1">MPSRRILSDTRKHLPFSERLHHFTWSWFECTMSTGAIATVLGQQPFGFDGLKTIGKIFFILDLVLFFTFCACITYRFVRTPPGTLRTSLHHPEESFFFGTFWQYGVPSSGPWLIKALEVLFWTYAGCAILVAVFQYHVIFDTRKLPVTDALPAWILPVYPFLVLGPLSAVLEYSQPPDAALPIMIGGICFEGLGWGVALIMYTIYVTRLINSDLPEPSKRPAMYVAVGPAAYTANTLVALGMQAPKVIPPNFLGIGSFPVGEVWKAIGVPCGIFLWLLAFWFCALSTVSVLNSWKEMHFTLNWWAFIFPNVGLTIALIQIANVLDSDGIKGVCSAMTVILVTLWIFVAIMNVRAVWRGDILWPGMDEDMEEEGEHEDDEEQRTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C5U1</accession>
    <name>A0A177C5U1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CC84DRAFT_1098051</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG03124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033489.1">
        <property type="nucleotide sequence ID" value="XM_018174749.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C5U1"/>
    <dbReference type="STRING" id="1460663.A0A177C5U1"/>
    <dbReference type="GeneID" id="28758235"/>
    <dbReference type="InParanoid" id="A0A177C5U1"/>
    <dbReference type="OrthoDB" id="3903189at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF149">
        <property type="entry name" value="UBID FAMILY DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="91"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="126"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="177"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="208"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="22"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="372"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="372"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAG03124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="401" mass="45250" checksum="59841A6B9B0318B3" modified="2016-09-07" version="1">MSRLEPESGIWYATCWLVLITRLISRKLHHGSWKALGTDDYLICVAMISMTVLMGAMHIVVRSSSNLIAPGEDISKFSADEIQRRIYGSKLVLVVEQMQCITIWLVKACLLLMYKRMTALLPQHKIVMIVSIYTALGFVVMEILYLGVWCRPFNQYWAVPPSNPQCSAATNHLITNAVLNISSDIMIIAIPMPLLFKVKLPKKNKAILIGIFLIGTFNIVAAVLNKYYSFSHPFGDEWTEWYLRESYTAFLCANLPLTYPLVQRIFRLKSWSHNSYDGRYLSGSLQRSAWRSGAVRSQRKSRIGLKSNPQHGGISKTVSVNVSNSRSIHNLERSESEERIYGPPTSRIELEQKAFDGRTEQHLWVPSVTIEMGSTSPTSAKAESMTTTGSIKSLDEAHVKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C5X7</accession>
    <name>A0A177C5X7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1220533</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441556">
        <property type="protein sequence ID" value="OAG02178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032543.1">
        <property type="nucleotide sequence ID" value="XM_018183179.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C5X7"/>
    <dbReference type="STRING" id="1460663.A0A177C5X7"/>
    <dbReference type="GeneID" id="28766665"/>
    <dbReference type="InParanoid" id="A0A177C5X7"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF105">
        <property type="entry name" value="METHYLTRANSFERASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG02178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="344" mass="39258" checksum="8F6FD98DB8C58392" modified="2016-09-07" version="1">MRPEDANIVVDSTYSRYHESDDDDSQSYISGQSLASSVTRYRYENGRRYHAYRDGSYYAPNDDTYSHYETIVHHLWLLTLDDKLYLAPIASPTHILDVGTGTGLWAVDMADAHPNAQILATDLSPTQSTTAPPNIRFEIDDAASEWTYPPESFDYIHVRGLTGCIRDWPFLYSQAYAHLQPGGYFEHAEFSVTTNADPDGTSVADKMYSTFSSTILSIGEEKTGQRFDTISHIGTWMRAAGFVDVVEQHFVWPIGPWPKDPKLKELGRWGERNWADGLEGWIMALYTRILGWKYEQVVEFVRAFRKVIKDRKNHYYQDVRVVYGRKPRVGEVVETPADKGEDAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C6D0</accession>
    <name>A0A177C6D0_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_968539</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG03314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033679.1">
        <property type="nucleotide sequence ID" value="XM_018188004.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C6D0"/>
    <dbReference type="GeneID" id="28771490"/>
    <dbReference type="InParanoid" id="A0A177C6D0"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF77">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26639">
        <property type="entry name" value="Het-6_barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG03314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="406" mass="46250" checksum="ECDB2626FCF55FC9" modified="2016-09-07" version="1">MHFLTLVKDYTRVDYSLDRTQVHRQMWRYIRHVRLYKPHRPSADTMESSSREALQTALPKTKLTNCTAMLLRTRKLDATDPRDKIFAIHGLLLVLGACLPNPDYSKSTEKVYREAAAAAIAHDARLHILGSITGESLIKDLPSWVPDWSCNQPISEIASWDDYVVLSEPETMLRISVIDGSRLTLGGVEVDTIQEHSVAFPDRYHDNRISEIKTLLGSLNMLEKHCQHKGPVEFFSGLIKKPWPRTRSPLKMFAKDFSVQVLSAYWIKGLKRFEENSDTLPNARYSASDIGYWAGKCAQEDGLTLGGEYIGGDVRFFHKLMRSLLDRKVMFRTERGYLGIASRALQISDRIVYFQGASVPMLIRKVESNWRLVAPAYIQDGMLEDKTNKLLASAGPDLNWKEYVLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C6E3</accession>
    <name>A0A177C6E3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Acyl-CoA N-acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CC84DRAFT_1219658</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the acetyltransferase family. RimJ subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG02701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033066.1">
        <property type="nucleotide sequence ID" value="XM_018183096.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C6E3"/>
    <dbReference type="STRING" id="1460663.A0A177C6E3"/>
    <dbReference type="GeneID" id="28766582"/>
    <dbReference type="InParanoid" id="A0A177C6E3"/>
    <dbReference type="OrthoDB" id="630895at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051531">
        <property type="entry name" value="N-acetyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43792:SF8">
        <property type="entry name" value="[RIBOSOMAL PROTEIN US5]-ALANINE N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43792">
        <property type="entry name" value="GNAT FAMILY, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G00765)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="4">
        <location>
            <begin position="26"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAG02701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="214" mass="23753" checksum="DD9D1199EB11725C" modified="2016-09-07" version="1">MLAEVQASDKPADSPLPEPLFRTKRLLARPLHPQDAESSQRACAPASITRYMSLAFAHPYTLEHSIAWIAMQKDAPHNNLALTTHSDPLTVIGGIGIKPGADVQSHTGEVGYWISEEHQGKGLMKEALAGFVEWTFLHRTSDGSKVEEGRSRKTRLFAAVFAENTASMRILEGCGFVREGVQRGHVHTRYGEITDLHLFGLGRGEWEERRKQGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C6L3</accession>
    <name>A0A177C6L3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RBR-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CC84DRAFT_1097039</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.31"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.3.2.31" evidence="2"/>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG02512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032877.1">
        <property type="nucleotide sequence ID" value="XM_018174697.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C6L3"/>
    <dbReference type="STRING" id="1460663.A0A177C6L3"/>
    <dbReference type="GeneID" id="28758183"/>
    <dbReference type="InParanoid" id="A0A177C6L3"/>
    <dbReference type="OrthoDB" id="10009520at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20335">
        <property type="entry name" value="BRcat_RBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22584">
        <property type="entry name" value="Rcat_RBR_unk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031127">
        <property type="entry name" value="E3_UB_ligase_RBR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002867">
        <property type="entry name" value="IBR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11685">
        <property type="entry name" value="RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01485">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00647">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="9">
        <location>
            <begin position="46"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAG02512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="332" mass="38451" checksum="DF271372E83E0D4B" modified="2016-09-07" version="1">MAVATESQYAGSVVDFSDNDEENEIEAGPSRYYAERQADAIAKLSKQFKCAVCHEYIMSGLMVHLPCNDRYCVSCLKELFIQATRDETLLPLRCHKQPIPLQLIARYLSADELAAYERANIEVSTADRTYCSNIQCGKFIPRDQIEPGTHRAVCDLCDTATCAICKNGFHYGLDCPDDPALRETRRIAEESGWKSCYHCGRILILRTGCNHMTCICKAQFCYVCGERWKTCRCDVADIDRIEERAEEVVDRDAGEVLPPVERQRRVERVRNELEQNHECEHPGRFQKLWRHEGYGGRRGFQCEMCDNRHWKYILQCRHCFINVCEECRRHRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C6U4</accession>
    <name>A0A177C6U4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1020720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441556">
        <property type="protein sequence ID" value="OAG02420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032785.1">
        <property type="nucleotide sequence ID" value="XM_018173378.1"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177C6U4"/>
    <dbReference type="GeneID" id="28756864"/>
    <dbReference type="InParanoid" id="A0A177C6U4"/>
    <dbReference type="OrthoDB" id="194139at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="272"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="390"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="516"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="608"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="848"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="955"/>
            <end position="1024"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1036"/>
            <end position="1154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1172"/>
            <end position="1248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1320"/>
            <end position="1359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="104"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="402"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="541"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="622"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="856"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="874"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="913"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="968"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="994"/>
            <end position="1023"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1048"/>
            <end position="1059"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1077"/>
            <end position="1088"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1097"/>
            <end position="1127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1128"/>
            <end position="1140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1172"/>
            <end position="1185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1194"/>
            <end position="1203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1349"/>
            <end position="1359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG02420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="1359" mass="148685" checksum="06DF6032EA975C1F" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C6W2</accession>
    <name>A0A177C6W2_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phospholipid metabolism enzyme regulator</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_835304</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG03383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033748.1">
        <property type="nucleotide sequence ID" value="XM_018187598.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C6W2"/>
    <dbReference type="STRING" id="1460663.A0A177C6W2"/>
    <dbReference type="GeneID" id="28771084"/>
    <dbReference type="InParanoid" id="A0A177C6W2"/>
    <dbReference type="OrthoDB" id="1204at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070772">
        <property type="term" value="C:PAS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010513">
        <property type="term" value="P:positive regulation of phosphatidylinositol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903778">
        <property type="term" value="P:protein localization to vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000011">
        <property type="term" value="P:vacuole inheritance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024260">
        <property type="entry name" value="Vac7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28258">
        <property type="entry name" value="VACUOLAR SEGREGATION PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28258:SF1">
        <property type="entry name" value="VACUOLAR SEGREGATION PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12751">
        <property type="entry name" value="Vac7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="390"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="219"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="286"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="473"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="614"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="291"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="304"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="617"/>
            <end position="628"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG03383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="654" mass="72062" checksum="8E7B2DAE426D7DC6" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C7P1</accession>
    <name>A0A177C7P1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Hydantoin racemase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1097838</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HyuE racemase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG02869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033234.1">
        <property type="nucleotide sequence ID" value="XM_018174734.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C7P1"/>
    <dbReference type="FunCoup" id="A0A177C7P1">
        <property type="interactions" value="32"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177C7P1"/>
    <dbReference type="GeneID" id="28758220"/>
    <dbReference type="InParanoid" id="A0A177C7P1"/>
    <dbReference type="OrthoDB" id="412018at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047661">
        <property type="term" value="F:amino-acid racemase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12500:FF:000003">
        <property type="entry name" value="Hydantoin racemase (Dcg1), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12500">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015942">
        <property type="entry name" value="Asp/Glu/hydantoin_racemase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052186">
        <property type="entry name" value="Hydantoin_racemase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053714">
        <property type="entry name" value="Iso_Racemase_Enz_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28047">
        <property type="entry name" value="PROTEIN DCG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28047:SF5">
        <property type="entry name" value="PROTEIN DCG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01177">
        <property type="entry name" value="Asp_Glu_race"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG02869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="243" mass="26060" checksum="72841F6B515B2A3A" modified="2016-09-07" version="1">MRSILIVQPNSTKSMTDALKPLVDQLGFKDTAYEYFTAPSGPKSINNEDDAAESVKHCLPELEKVLSQHDGFLVACYSKHPLVPILKEQKAIRSGRKAVTGIFEASVSTSLQIIHPDEKFGIVSTGKVWETILSEAVVDFLGTGSDAGKRFAGVETTGLNATDLHDAPPEEVRKRMKDAVKRLLKNGKVGAICLGCAGMAGMDTMVREACVEELGADDGDRVRIVDGVVAGVAWLEGAVRSGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2023-06-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C8M1</accession>
    <name>A0A177C8M1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_865643</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG03746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034111.1">
        <property type="nucleotide sequence ID" value="XM_018187699.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C8M1"/>
    <dbReference type="GeneID" id="28771185"/>
    <dbReference type="InParanoid" id="A0A177C8M1"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG03746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="226" mass="25548" checksum="A47F8407B260EBB6" modified="2016-09-07" version="1">MWALWGMGFTNVHSPCYTGTWGLRPQHGRSLRPAKRLLSFGHIQPVLHAHPHGNPSRARLNHRLLLVIDSHRLTVETRLSQDPVAHHARITRYQQRWTNASLPRFWKPLRAPCPCRRVIHSWGPLAICLTSPHIARPCHAYSIRAVQAPMHVPCRACAIQLNSIRAKGPRHQQFLECLTEGRAQTQSQILYESCCKPHMGGCDISSRSLVPSPIRKLPARTQAAPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C9L8</accession>
    <name>A0A177C9L8_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1166197</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG04076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034441.1">
        <property type="nucleotide sequence ID" value="XM_018178891.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C9L8"/>
    <dbReference type="GeneID" id="28762377"/>
    <dbReference type="InParanoid" id="A0A177C9L8"/>
    <dbReference type="OrthoDB" id="5398371at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="14"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG04076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="423" mass="48019" checksum="04E892EE28A4E4EA" modified="2016-09-07" version="1">MAEEDALVVIAPAGDLILDVRQAEGTPRFSYRVHSKVLRDSSRYFENLLSDRFREGEQLATALEALKVAGLSDLADAPVDALPRVAILDVGRTSALSVRNLVADFLRAIHGEDLSAATPPVPNLANIAVVADRFDATDTLSRYVRKRKYGALLDAKSGKGKISIGMTEERVRQKLLVGLLFDHAPWVTRYSKHLILRDSSQWQPGVEEDHTKPLWWDLPNGVEDELIQRREYILETINSLQSHFLKLYTSGERQCKLGYDTSVQCDSFQLGEMIRFFIRLGTVRLQGTIYDNTEPTYHTGDIERLLESLRQCSSYQVDRNHAHCGLRTRLLPLVDLLQNQLCLDTTSLDVGLCLECWNNHRDNYAWSVAKRPVLWAQHPSVTGNRMLSKGHRRTPSSCLHRHIVVRDLFMATDRNWTARDAVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C9Q1</accession>
    <name>A0A177C9Q1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GTPase activating protein-like protein GYP1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1165685</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG03450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033815.1">
        <property type="nucleotide sequence ID" value="XM_018178774.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C9Q1"/>
    <dbReference type="FunCoup" id="A0A177C9Q1">
        <property type="interactions" value="1068"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177C9Q1"/>
    <dbReference type="GeneID" id="28762260"/>
    <dbReference type="InParanoid" id="A0A177C9Q1"/>
    <dbReference type="OrthoDB" id="26371at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.750:FF:000007">
        <property type="entry name" value="TBC1 domain family member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000037">
        <property type="entry name" value="TBC1 domain family member 22A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000001">
        <property type="entry name" value="TBC1 domain family member 22B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.750">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957:SF26">
        <property type="entry name" value="LD44506P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="2">
        <location>
            <begin position="245"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="46"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG03450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="581" mass="65078" checksum="FA291BEEFC775CBF" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CA87</accession>
    <name>A0A177CA87_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_884367</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG04041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034406.1">
        <property type="nucleotide sequence ID" value="XM_018187779.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CA87"/>
    <dbReference type="STRING" id="1460663.A0A177CA87"/>
    <dbReference type="GeneID" id="28771265"/>
    <dbReference type="InParanoid" id="A0A177CA87"/>
    <dbReference type="OrthoDB" id="3935400at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="130"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="247"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="284"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="332"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG04041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="353" mass="38720" checksum="2DF185B263191BF9" modified="2016-09-07" version="1">MVPRRDGLDAQKRNGDDRPSWVIDDDSPMTATSSQFSRPTDDDDYTQYGPLSSTTWDPPPFASQHLASSTFITSSTVNTTPQLSTGGYTATVTASIFPVASDSPSTDFPSIEGGSTADHERKEHSNQGPMYAAAGAVPVIVIAIIGLVVFFCMRKRRTQRRRTQRQQQAATQNHVVPEVKFQQPTVHAYRAPAVPVSRAPSYTSYEDNMQRPTSPPPVILGPISAGSSGNYMTGIDTSDIISTRNERMGLGDPFVDGSSLHEEPPPPYKPRSVASRNSSLRIPRSSMSVSSQHSRYSSQRQVFRPLQNPFEDPREDDAVSNLSGPTLHRNSDNMSVVSDFSYQQDPQVGRRSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CAH4</accession>
    <name>A0A177CAH4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SigF-like NTF2-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_1165906</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG03720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034085.1">
        <property type="nucleotide sequence ID" value="XM_018178824.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CAH4"/>
    <dbReference type="STRING" id="1460663.A0A177CAH4"/>
    <dbReference type="GeneID" id="28762310"/>
    <dbReference type="InParanoid" id="A0A177CAH4"/>
    <dbReference type="OrthoDB" id="2344312at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057514">
        <property type="entry name" value="NTF2_SigF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35393">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35393:SF1">
        <property type="entry name" value="SNOAL-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24840">
        <property type="entry name" value="NTF2_SigF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="82"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="145"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="SigF-like NTF2-like" evidence="3">
        <location>
            <begin position="1"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAG03720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="219" mass="25902" checksum="77F17D57AA58BB17" modified="2016-09-07" version="1">MENPAKDITGVIHLLTQSPPSIQRETIETYFTSNASFTHPFCRTGSFDNSRSLIRAIYRWYKILSPKIELTVNSVAYDERNLILYVNITQVFGIWMVPFHRARVNLTTVLELKQNRDDNKYYIQSQNDLYQTDEFVKFVIPPSWIFVWLWQFWATFFCFLGVFALWPISYAEQWAWDEGESRKDRKREEGRKAQKGSDLLDGIELQDLERKALVNNPSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CAT6</accession>
    <name>A0A177CAT6_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6604 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1206013</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG04281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034646.1">
        <property type="nucleotide sequence ID" value="XM_018182007.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CAT6"/>
    <dbReference type="STRING" id="1460663.A0A177CAT6"/>
    <dbReference type="GeneID" id="28765493"/>
    <dbReference type="InParanoid" id="A0A177CAT6"/>
    <dbReference type="OrthoDB" id="5238236at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046539">
        <property type="entry name" value="DUF6604"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38795">
        <property type="entry name" value="DUF6604 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38795:SF1">
        <property type="entry name" value="DUF6604 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20253">
        <property type="entry name" value="DUF6604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6604" evidence="2">
        <location>
            <begin position="11"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG04281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="845" mass="94522" checksum="E997425D2AA5946B" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CBS4</accession>
    <name>A0A177CBS4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">WD40 repeat-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CC84DRAFT_1165155</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the WD repeat MORG1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG04776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035141.1">
        <property type="nucleotide sequence ID" value="XM_018178654.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CBS4"/>
    <dbReference type="STRING" id="1460663.A0A177CBS4"/>
    <dbReference type="GeneID" id="28762140"/>
    <dbReference type="InParanoid" id="A0A177CBS4"/>
    <dbReference type="OrthoDB" id="1068471at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051980">
        <property type="entry name" value="WD_repeat_MORG1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22842:SF3">
        <property type="entry name" value="WD REPEAT DOMAIN-CONTAINING PROTEIN 83"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22842">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="12"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="70"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="112"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="299"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAG04776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="334" mass="35881" checksum="EADC37C5F9EDC0FC" modified="2016-09-07" version="1">MPSFPTTPIAKLTGHTGPVHAVAYSSSPHSYILTGAADRTIRLYNPSKAPPSSVAPTSSAAYPPGLVTKYNAHGYEVLSIDVNAANDRFVSTGGDKTVFLWDVQTAQTVRRFTGHAGRVNRGVFGGEGDSVIVSASFDGTVRIWDVRSNSYKPIMTFSDAKDSVTDVLAFDGEIVSGSVDGRVRSYDLRTGYCEVDVIGYPVTSLTLSKKGTEVLVSSLDSTVRLMDRANGQLLKAYRDEAFLNTDLRVRSTLGLNDSVVLSGSDDGMVFAWDLLGGTALHKFRHSELREVRGTAEKKEKGKKDIVSAVAFCPSRREWASAGGDGNVVVWGTDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CCB3</accession>
    <name>A0A177CCB3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1165197</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG04821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035186.1">
        <property type="nucleotide sequence ID" value="XM_018178663.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CCB3"/>
    <dbReference type="GeneID" id="28762149"/>
    <dbReference type="InParanoid" id="A0A177CCB3"/>
    <dbReference type="OrthoDB" id="4400538at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG04821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="75" mass="8634" checksum="B82BD7CD6D5A120C" modified="2016-09-07" version="1">MFATHALNQLRRYSTSLPRDPHYRLKATLMTGYLVSAFTLPFVPPLLESRRTKADGTYLTRENVYCSAHYHGCAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CCW7</accession>
    <name>A0A177CCW7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1165036</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG04618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034983.1">
        <property type="nucleotide sequence ID" value="XM_018178629.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CCW7"/>
    <dbReference type="GeneID" id="28762115"/>
    <dbReference type="InParanoid" id="A0A177CCW7"/>
    <dbReference type="OrthoDB" id="3021074at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="53"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="150"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="301"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="401"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="445"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="471"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG04618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="524" mass="58748" checksum="1E3A75E6AE7059C5" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CDK0</accession>
    <name>A0A177CDK0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1176948</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG04780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035145.1">
        <property type="nucleotide sequence ID" value="XM_018180254.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CDK0"/>
    <dbReference type="STRING" id="1460663.A0A177CDK0"/>
    <dbReference type="GeneID" id="28763740"/>
    <dbReference type="InParanoid" id="A0A177CDK0"/>
    <dbReference type="OrthoDB" id="5427664at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053018">
        <property type="entry name" value="Elsinochrome_Biosynth-Asso"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37577">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37577:SF1">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="37"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="113"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="158"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="280"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="321"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="391"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="405"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG04780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="415" mass="45794" checksum="269F8FE57E38DD07" modified="2016-09-07" version="1">MGVFLSSLSTCAAKDPEGSSFQCGLPDTFESDGDIAGLGVFIAFAVAVITSLFASVYVLVIEGFEYFSKRDLYYHKLRMLADEYLISLSDAQAVTSLALLVTANFYVGCTISAYHYDLVCSLVLMSSAAHIGSLAVMHKYFDVDKCQGWQRVWQWVRFSLRVFMVIASFVLSNYLFRHRLESKIFPSFKPASDDITTNNRTHSTGLVLPAVCFIDHPGQSNAVVYNNFTASPNWTRNYTTHASSNHSASNGNSNTSTFAVMPAFATFNSNDDLSSDGDLKAFYCLIGACAVAALTSFLLVLFKKQGTCGHSLLCRHHFAYLLRWGCFFTTYIIALSSWNRFTKLQNWMIGSGWFEGSDTGERSIDSFGQLMPLILLALPVLALIEALAEKSDPPQKGDANWIGLQDKRNPDGFGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CDQ8</accession>
    <name>A0A177CDQ8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_809870</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG04939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035304.1">
        <property type="nucleotide sequence ID" value="XM_018187508.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CDQ8"/>
    <dbReference type="GeneID" id="28770994"/>
    <dbReference type="InParanoid" id="A0A177CDQ8"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG04939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="145" mass="15898" checksum="2BD8FC0FAC07A51F" modified="2016-09-07" version="1">MTKPKRRKSLATGHALPGHAAPGVIVHTNSRQLCISTSLNTRPGCTPISWYAVRLEDMYTLRTERYGSEPSLPRPSARLRSSNPTFSPCDQISHGATGCLFLAIIRNCNSSVATTAERYTLRRPKSSLSQEGSLLLSIRASCILR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CE89</accession>
    <name>A0A177CE89_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">MFS alpha-glucoside transporter-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CC84DRAFT_1244758</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG05945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036310.1">
        <property type="nucleotide sequence ID" value="XM_018184163.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CE89"/>
    <dbReference type="GeneID" id="28767649"/>
    <dbReference type="InParanoid" id="A0A177CE89"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000254">
        <property type="entry name" value="MAL31p Maltose permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF83">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="147"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="181"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="210"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="302"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="338"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="365"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="398"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="432"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="467"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="45"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OAG05945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="528" mass="58315" checksum="0E3BC1C0CAFB1EB3" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CES4</accession>
    <name>A0A177CES4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DUF1446-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_1205449</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG05721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036086.1">
        <property type="nucleotide sequence ID" value="XM_018181973.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CES4"/>
    <dbReference type="STRING" id="1460663.A0A177CES4"/>
    <dbReference type="GeneID" id="28765459"/>
    <dbReference type="InParanoid" id="A0A177CES4"/>
    <dbReference type="OrthoDB" id="5863171at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010839">
        <property type="entry name" value="AtuA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025496">
        <property type="entry name" value="DUF4387"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07287">
        <property type="entry name" value="AtuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14330">
        <property type="entry name" value="DUF4387"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyclic terpene utilisation N-terminal" evidence="2">
        <location>
            <begin position="105"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4387" evidence="3">
        <location>
            <begin position="534"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="494"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAG05721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="658" mass="71178" checksum="D68809C5513A0005" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CEU8</accession>
    <name>A0A177CEU8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative aflatoxin B1-aldehyde reductase GliO-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1165558</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG05250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035615.1">
        <property type="nucleotide sequence ID" value="XM_018178745.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CEU8"/>
    <dbReference type="STRING" id="1460663.A0A177CEU8"/>
    <dbReference type="GeneID" id="28762231"/>
    <dbReference type="InParanoid" id="A0A177CEU8"/>
    <dbReference type="OrthoDB" id="2310150at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19075">
        <property type="entry name" value="AKR_AKR7A1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050523">
        <property type="entry name" value="AKR_Detox_Biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364:SF4">
        <property type="entry name" value="NAD(P)-LINKED OXIDOREDUCTASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364">
        <property type="entry name" value="NADH-SPECIFIC METHYLGLYOXAL REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="2">
        <location>
            <begin position="8"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG05250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="328" mass="36925" checksum="3D96C01E31875E8E" modified="2016-09-07" version="1">MASPKTNRLILGLMTIGPDTELGARITSLDTYKQCLDYLSKKGYHELDTAGSYVGGKQEAFTRDADFRSRGFEIASKVYPVQPGDHEPEKLRSKWLASLEKLGVDSTDILYLHAPDRATPFETTLECVNQLYQEGRFKKLGLSNYAAWEVAEIVGICERRGFVKPAIYQGMYNAITRALEAELLPCLRKFNIDLVIYNPLVGGLFSGKYSTLDAPAEGRFSDKVNYGKMYRERYFKESVIDALALVEPVAKEHGVPLIEVALRWCVHHSKLKMRSEGGNDGVIIGISSYEQLEQNVEAFEKGPLPQPLVDVLDKAWERTRGDAVTYWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2023-06-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CFA0</accession>
    <name>A0A177CFA0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1176297</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG06265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036630.1">
        <property type="nucleotide sequence ID" value="XM_018180208.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CFA0"/>
    <dbReference type="GeneID" id="28763694"/>
    <dbReference type="InParanoid" id="A0A177CFA0"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG06265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="136" mass="14477" checksum="AAC1C44241A3D304" modified="2016-09-07" version="1">MGGRLYPGLCMYRFNPALEDGEAEAGEVEVEDPEVGEAEAGEAEAGEVESEEAESEEVVVWEVEAVELPFVPSVSAQMINSSTFAHLKRSTHPVQHSTAPHPGLDTICFAQGRENSPGSLRAPIGSALVLSWRVGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CFA3</accession>
    <name>A0A177CFA3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1164015</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG05498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035863.1">
        <property type="nucleotide sequence ID" value="XM_018178393.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CFA3"/>
    <dbReference type="STRING" id="1460663.A0A177CFA3"/>
    <dbReference type="GeneID" id="28761879"/>
    <dbReference type="InParanoid" id="A0A177CFA3"/>
    <dbReference type="OrthoDB" id="10264707at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052742">
        <property type="entry name" value="Mito_N-acetyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43138">
        <property type="entry name" value="ACETYLTRANSFERASE, GNAT FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43138:SF1">
        <property type="entry name" value="N-ACETYLTRANSFERASE ACA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="163"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG05498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="280" mass="30308" checksum="20AC37FCB1367830" modified="2016-09-07" version="1">MAYGKVRGISKLLGEIPARIYPIESNASESRAAILTVPVDFNAGDELDAKLVEKLHHDFNEAIDEGRTYPQEDIMDVEAYKNYFMSYDLVLGLILTKAQLESLHSTSGVPKLGVPLSESQLSNVKVGSSKIRALSQSSARASIDLPNQADTYAFVYYIKPNYPGRSSHLCNGGFMVPSGARGLGLGRIAARSFCFYGPAVGYRGSVFNLVYASNEASVRLWTKLGFTNVGRIPEAGRLKKVGGGGEEYADAWVVHGDFRKIGYRDNEEQGGVGLVTPAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CG73</accession>
    <name>A0A177CG73_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Cell division protease ftsH</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CC84DRAFT_1164546</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the peptidase M41 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the N-terminal section; belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG06231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036596.1">
        <property type="nucleotide sequence ID" value="XM_018178508.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CG73"/>
    <dbReference type="FunCoup" id="A0A177CG73">
        <property type="interactions" value="668"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CG73"/>
    <dbReference type="GeneID" id="28761994"/>
    <dbReference type="InParanoid" id="A0A177CG73"/>
    <dbReference type="OrthoDB" id="1413014at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005745">
        <property type="term" value="C:m-AAA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097002">
        <property type="term" value="C:mitochondrial inner boundary membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140567">
        <property type="term" value="F:membrane protein dislocase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034982">
        <property type="term" value="P:mitochondrial protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065003">
        <property type="term" value="P:protein-containing complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd19501">
        <property type="entry name" value="RecA-like_FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000019">
        <property type="entry name" value="AFG3-like AAA ATPase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.760:FF:000003">
        <property type="entry name" value="AFG3-like AAA ATPase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000001">
        <property type="entry name" value="ATP-dependent zinc metalloprotease FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1690.20:FF:000003">
        <property type="entry name" value="Mitochondrial inner membrane AAA protease Yta12, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1690.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.760">
        <property type="entry name" value="Peptidase M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01458">
        <property type="entry name" value="FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050928">
        <property type="entry name" value="ATP-dep_Zn_Metalloprotease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005936">
        <property type="entry name" value="FtsH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011546">
        <property type="entry name" value="Pept_M41_FtsH_extracell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000642">
        <property type="entry name" value="Peptidase_M41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037219">
        <property type="entry name" value="Peptidase_M41-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01241">
        <property type="entry name" value="FtsH_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43655:SF2">
        <property type="entry name" value="AFG3 LIKE MATRIX AAA PEPTIDASE SUBUNIT 2, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43655">
        <property type="entry name" value="ATP-DEPENDENT PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06480">
        <property type="entry name" value="FtsH_ext"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01434">
        <property type="entry name" value="Peptidase_M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140990">
        <property type="entry name" value="FtsH protease domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="19" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="19" id="KW-0132">Cell division</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 19" id="KW-0645">Protease</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="18">
        <location>
            <begin position="415"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="44"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="163"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="847"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="55"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="167"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="OAG06231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="874" mass="96715" checksum="3C09A836325F5F3B" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CG94</accession>
    <name>A0A177CG94_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CC84DRAFT_1196150</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG05859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036224.1">
        <property type="nucleotide sequence ID" value="XM_018181440.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CG94"/>
    <dbReference type="STRING" id="1460663.A0A177CG94"/>
    <dbReference type="GeneID" id="28764926"/>
    <dbReference type="InParanoid" id="A0A177CG94"/>
    <dbReference type="OrthoDB" id="3945418at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002397">
        <property type="entry name" value="Cyt_P450_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46696">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46696:SF6">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00359">
        <property type="entry name" value="BP450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAG05859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="406" mass="45456" checksum="E38609EA2869B3C2" modified="2016-09-07" version="1">MTAATCPFAGAPARSDFELAESSIPSDIYEQFDTLRSKCPVAYSSQMGGYWMLTRYEDVKNCASDTSTFISSVKAVIPSDPRGTRRPPLNTDPPVHTPYRTAIDRTLKISRLKRLESVLEDHARREWKVLVERGRGDVSADFGANFAAWVEVTWLNLGDESAPMLAKTAAAWVNAWREQQTDVVKFYSEKLYDMARALFRDRRENPRDVESDPASSLLAERVNGQPIAEEKLIDALRQCLVVGMVAPPILFGNMATHLAQDKALQNRLRENPELIPSAVEEFVRLYVPYRGFSRTASSPVELHGRTLNPGEPITMTYAAANRDPEVFSNPHEFVLGRENVSKHLGFGRGRHRCAGMPLARMALQVGLKVMLENSQDWDLDGELQYAKMPEMGIISCPVRIISVVEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CHC7</accession>
    <name>A0A177CHC7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">RNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_1259391</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">May be involved in the turnover of nuclear polyadenylated (pA+) RNA.</text>
    </comment>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG06117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036482.1">
        <property type="nucleotide sequence ID" value="XM_018184907.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CHC7"/>
    <dbReference type="STRING" id="1460663.A0A177CHC7"/>
    <dbReference type="GeneID" id="28768393"/>
    <dbReference type="InParanoid" id="A0A177CHC7"/>
    <dbReference type="OrthoDB" id="443401at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12257">
        <property type="entry name" value="RRM1_RBM26_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002483">
        <property type="entry name" value="PWI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045137">
        <property type="entry name" value="RBM26/27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14398">
        <property type="entry name" value="RNA RECOGNITION RRM/RNP DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14398:SF0">
        <property type="entry name" value="ZINC FINGER PROTEIN SWM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01480">
        <property type="entry name" value="PWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="7">
        <location>
            <begin position="299"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="380"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="299"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="84"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="88"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="116"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00043866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAG06117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="737" mass="80843" checksum="6B6DD33E9598FB13" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CHL9</accession>
    <name>A0A177CHL9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF3253 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1217659</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG06442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036807.1">
        <property type="nucleotide sequence ID" value="XM_018182916.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CHL9"/>
    <dbReference type="GeneID" id="28766402"/>
    <dbReference type="InParanoid" id="A0A177CHL9"/>
    <dbReference type="OrthoDB" id="2563170at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021660">
        <property type="entry name" value="DUF3253"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11625">
        <property type="entry name" value="DUF3253"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG06442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="105" mass="12532" checksum="EF999DBDF1EA019E" modified="2016-09-07" version="1">MILDHDQEEILRKHLKALLGRRPYPKTICPSEVARALDQEELDKLECYDWRDCMENVRNLCWEMRAFGVVEVLQKGEVVKAKSIDEIIGPIRVRYHPDHRRQEMM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CI47</accession>
    <name>A0A177CI47_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Heme peroxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_1204578</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Homotetramer.</text>
    </comment>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG06931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037296.1">
        <property type="nucleotide sequence ID" value="XM_018181914.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CI47"/>
    <dbReference type="STRING" id="1460663.A0A177CI47"/>
    <dbReference type="GeneID" id="28765400"/>
    <dbReference type="InParanoid" id="A0A177CI47"/>
    <dbReference type="OrthoDB" id="823504at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20612">
        <property type="entry name" value="CYP_LDS-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09817">
        <property type="entry name" value="linoleate_diol_synthase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.640.10">
        <property type="entry name" value="Haem peroxidase domain superfamily, animal type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019791">
        <property type="entry name" value="Haem_peroxidase_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037120">
        <property type="entry name" value="Haem_peroxidase_sf_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050783">
        <property type="entry name" value="Oxylipin_biosynth_metab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034812">
        <property type="entry name" value="Ppo-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11903:SF13">
        <property type="entry name" value="LINOLEATE 10R-LIPOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11903">
        <property type="entry name" value="PROSTAGLANDIN G/H SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03098">
        <property type="entry name" value="An_peroxidase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00457">
        <property type="entry name" value="ANPEROXIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50292">
        <property type="entry name" value="PEROXIDASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0349">Heme</keyword>
    <keyword evidence="5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="6">
        <location>
            <position position="412"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR619791-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAG06931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1111" mass="123328" checksum="1B7877A6B95CC39F" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CIB7</accession>
    <name>A0A177CIB7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">chitin synthase</fullName>
            <ecNumber evidence="2">2.4.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CC84DRAFT_608924</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.4.1.16" evidence="2"/>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG06570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036935.1">
        <property type="nucleotide sequence ID" value="XM_018186870.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CIB7"/>
    <dbReference type="STRING" id="1460663.A0A177CIB7"/>
    <dbReference type="GeneID" id="28770356"/>
    <dbReference type="InParanoid" id="A0A177CIB7"/>
    <dbReference type="OrthoDB" id="370884at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004100">
        <property type="term" value="F:chitin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004835">
        <property type="entry name" value="Chitin_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914:SF13">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03142">
        <property type="entry name" value="Chitin_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="156"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="546"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="569"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="602"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="642"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="29"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="642"/>
            <end position="651"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OAG06570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="675" mass="76866" checksum="2CCE716F6DC6F5C1" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CIF9</accession>
    <name>A0A177CIF9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">FabD/lysophospholipase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CC84DRAFT_1117518</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG07293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037658.1">
        <property type="nucleotide sequence ID" value="XM_018175496.1"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CIF9"/>
    <dbReference type="GeneID" id="28758982"/>
    <dbReference type="InParanoid" id="A0A177CIF9"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047499">
        <property type="term" value="F:calcium-independent phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019369">
        <property type="term" value="P:arachidonate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046486">
        <property type="term" value="P:glycerolipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd19757">
        <property type="entry name" value="Bbox1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07199">
        <property type="entry name" value="Pat17_PNPLA8_PNPLA9_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16449">
        <property type="entry name" value="RING-HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24185">
        <property type="entry name" value="CALCIUM-INDEPENDENT PHOSPHOLIPASE A2-GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24185:SF1">
        <property type="entry name" value="CALCIUM-INDEPENDENT PHOSPHOLIPASE A2-GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 8" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="6 8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="10">
        <location>
            <begin position="724"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="domain" description="PNPLA" evidence="11">
        <location>
            <begin position="793"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1284"/>
            <end position="1363"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXGXXG" evidence="8">
        <location>
            <begin position="797"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXSXG" evidence="8">
        <location>
            <begin position="830"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="DGA/G" evidence="8">
        <location>
            <begin position="962"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="17"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="35"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1311"/>
            <end position="1321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1322"/>
            <end position="1336"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8">
        <location>
            <position position="832"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="962"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OAG07293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1445" mass="163355" checksum="5E2CA13C91ADFFD8" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CII4</accession>
    <name>A0A177CII4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative pantothenate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CC84DRAFT_1142606</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG06659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037024.1">
        <property type="nucleotide sequence ID" value="XM_018176374.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CII4"/>
    <dbReference type="GeneID" id="28759860"/>
    <dbReference type="InParanoid" id="A0A177CII4"/>
    <dbReference type="OrthoDB" id="3639251at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000065">
        <property type="entry name" value="Putative MFS pantothenate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF43">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="49"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="149"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="215"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="285"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="324"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="354"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="378"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="412"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="446"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="57"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAG06659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="481" mass="54444" checksum="CAF6988F0BD9FE84" modified="2016-09-07" version="1">MSESKSPRKTDTTVDERAVGLSPAKLPLSKRILGIVWDSLDKTPEERAFIAKIDFWILTYVCIAYFVKYLDQTNISNAYVSGMKEDLHLTGNDLNYLTTYWTIGYILGQIPSQLILLKIRPSIWLPTLELIWGFLVMGMAGAKNVRSLYALRFFIGLLEASAYPGIMTLLGNWYTPQELGKRACIFQASSSAAQMFSGYLQAGLLRMDGKHGIAAWQWLFIFDGIIGVPIALYGFFAIPDQPTSSKARWLPPAQKQMAIDRMEACRRRPVKRLTRRKLRDIFTSWPLYFFCAIFIAHVLGIRIYSYFNVWLKSTKKWSTSDINLIPTAGYGAQIFFTLSYAWTSDAIGMRWPVIIAACVPALIGCIVLSVWPEHNIPAMMAGWILTFLETGAGALIITWINEICSESAEHRIVIIGVVEAIAFTFQAWVPLFIYDTGKAPHFPIGYQMAAMFFAIEVVLTLCVWQIHKRYPVKSEKEDEAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CIP0</accession>
    <name>A0A177CIP0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">HlyIII-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_1162995</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ADIPOR family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG06647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037012.1">
        <property type="nucleotide sequence ID" value="XM_018178148.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CIP0"/>
    <dbReference type="STRING" id="1460663.A0A177CIP0"/>
    <dbReference type="GeneID" id="28761634"/>
    <dbReference type="InParanoid" id="A0A177CIP0"/>
    <dbReference type="OrthoDB" id="529367at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006882">
        <property type="term" value="P:intracellular zinc ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004254">
        <property type="entry name" value="AdipoR/HlyIII-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855:SF52">
        <property type="entry name" value="ADIPONECTIN RECEPTOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855">
        <property type="entry name" value="ADIPOR/PROGESTIN RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03006">
        <property type="entry name" value="HlyIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="148"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="183"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="216"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="246"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="284"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="289"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="293"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR604254-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAG06647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="315" mass="35441" checksum="1E72F9A37645B457" modified="2016-09-07" version="1">MASLAIALRLPLLLFRKPSKGRKPSKASTEDDAPQRLLTYNELPDWYRIEASPFITASYRPPSHSVAKSIQSLAHLHNETANIYTHLIPALVLAFSLPLLQLNISDAYADAPWLDRFMLTLTPIAALFTFSASANFHTLCNHSDAVSLSCLLLDFTGILTLILASFISGIYVGFYNHPFEQRLYWTMITTLTATSALLVLHPSLQGMQYRPHRTTAFVLTVLSGLGPTFHGMYVHGVSRGWHECGVKWWAAEGCWYALGVVFFVSRWPERWAWRNERTRGMFDIWGGSHGIFHVCVVVGAACHCWGVWEAWRCAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CIU3</accession>
    <name>A0A177CIU3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1216396</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG07435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037800.1">
        <property type="nucleotide sequence ID" value="XM_018182797.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CIU3"/>
    <dbReference type="GeneID" id="28766283"/>
    <dbReference type="InParanoid" id="A0A177CIU3"/>
    <dbReference type="OrthoDB" id="10580363at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG07435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="120" mass="13082" checksum="09233DF6560474F0" modified="2016-09-07" version="1">MLAEQRLDKRIYLFGVSEPVSAGILKVLKGTSPPAIPRGLMSEARQSSTMGSDWDAVEVLTGTDWNALEQKSAGEHAVELYGFVKKYDIQLLSRRARQWIMAAIDPGGAAGRGKCEAVFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CJ45</accession>
    <name>A0A177CJ45_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cellobiose dehydrogenase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CC84DRAFT_1195683</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG07554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037919.1">
        <property type="nucleotide sequence ID" value="XM_018181416.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CJ45"/>
    <dbReference type="STRING" id="1460663.A0A177CJ45"/>
    <dbReference type="GeneID" id="28764902"/>
    <dbReference type="InParanoid" id="A0A177CJ45"/>
    <dbReference type="OrthoDB" id="507128at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09630">
        <property type="entry name" value="CDH_like_cytochrome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1210">
        <property type="entry name" value="Cellobiose dehydrogenase, cytochrome domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054539">
        <property type="entry name" value="Beta-prop_PDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015920">
        <property type="entry name" value="Cellobiose_DH-like_cyt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011041">
        <property type="entry name" value="Quinoprot_gluc/sorb_DH_b-prop"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47797:SF5">
        <property type="entry name" value="CELLOBIOSE DEHYDROGENASE CYTOCHROME DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47797">
        <property type="entry name" value="DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G05805)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16010">
        <property type="entry name" value="CDH-cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22807">
        <property type="entry name" value="TrAA12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49344">
        <property type="entry name" value="CBD9-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50952">
        <property type="entry name" value="Soluble quinoprotein glucose dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008058235" evidence="2">
        <location>
            <begin position="24"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="domain" description="Cellobiose dehydrogenase-like cytochrome" evidence="3">
        <location>
            <begin position="27"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="Pyrroloquinoline quinone-dependent pyranose dehydrogenase beta-propeller" evidence="4">
        <location>
            <begin position="270"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="218"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF22807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAG07554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="661" mass="70670" checksum="C4EE39E36C843270" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CJH2</accession>
    <name>A0A177CJH2_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CorA-like transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_1175438</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG07684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038049.1">
        <property type="nucleotide sequence ID" value="XM_018180156.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CJH2"/>
    <dbReference type="STRING" id="1460663.A0A177CJH2"/>
    <dbReference type="GeneID" id="28763642"/>
    <dbReference type="InParanoid" id="A0A177CJH2"/>
    <dbReference type="OrthoDB" id="5396681at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058257">
        <property type="entry name" value="CorA-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26616">
        <property type="entry name" value="CorA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="504"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="546"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="domain" description="CorA-like transporter" evidence="3">
        <location>
            <begin position="242"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF26616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAG07684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="601" mass="69073" checksum="A03213F438C1EB7C" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CK00</accession>
    <name>A0A177CK00_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Prolyl 4-hydroxylase alpha subunit domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CC84DRAFT_1163419</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG07198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037563.1">
        <property type="nucleotide sequence ID" value="XM_018178258.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CK00"/>
    <dbReference type="STRING" id="1460663.A0A177CK00"/>
    <dbReference type="GeneID" id="28761744"/>
    <dbReference type="InParanoid" id="A0A177CK00"/>
    <dbReference type="OrthoDB" id="69177at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031418">
        <property type="term" value="F:L-ascorbic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004656">
        <property type="term" value="F:procollagen-proline 4-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045054">
        <property type="entry name" value="P4HA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006620">
        <property type="entry name" value="Pro_4_hyd_alph"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044862">
        <property type="entry name" value="Pro_4_hyd_alph_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869:SF241">
        <property type="entry name" value="FE2OG DIOXYGENASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869">
        <property type="entry name" value="PROLYL 4-HYDROXYLASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13640">
        <property type="entry name" value="2OG-FeII_Oxy_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00702">
        <property type="entry name" value="P4Hc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prolyl 4-hydroxylase alpha subunit" evidence="6">
        <location>
            <begin position="36"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAG07198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="257" mass="28954" checksum="3B54BDDAFA0D1F27" modified="2016-09-07" version="1">MASHKLPEGFLSGPAPALKKTTIDFAKEGIPAYAGMYAVVLDGLLSSEECSQLISLAEATTAGRWERAMINVGDGQQELYEEVRKCGRIIWDSRELMEKLWARILRDVPEILEIKDWPDVTGWGRRDVTWVATRLNERARFLKYVGGEYFKAHEDGMYITPIGTERSFFTLHLYLNDAVGKDGKAQLKGGATTFHNRFMDPELDLHVLPKCGRVLIFQHEGLLHSGQDVERGTKYTMRTDIMYAVEGELGEGPEGGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CKQ6</accession>
    <name>A0A177CKQ6_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Essential protein Yae1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_1175330</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LTO1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG07542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037907.1">
        <property type="nucleotide sequence ID" value="XM_018180145.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CKQ6"/>
    <dbReference type="STRING" id="1460663.A0A177CKQ6"/>
    <dbReference type="GeneID" id="28763631"/>
    <dbReference type="InParanoid" id="A0A177CKQ6"/>
    <dbReference type="OrthoDB" id="48036at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019191">
        <property type="entry name" value="Essential_protein_Yae1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052436">
        <property type="entry name" value="LTO1_adapter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28532">
        <property type="entry name" value="GEO13458P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28532:SF1">
        <property type="entry name" value="ORAL CANCER OVEREXPRESSED 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09811">
        <property type="entry name" value="Yae1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Essential protein Yae1 N-terminal" evidence="3">
        <location>
            <begin position="23"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="148"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAG07542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="192" mass="20798" checksum="6C0282E149762ECC" modified="2016-09-07" version="1">MASNPDPFDSILTLEDDLYTTAYAQGAADGSRAGRIEGRIFGLEKGFDKFAALGQLHGRAVVWGARLPAAPVLPTNLEPSVEKEKDSEAQVLRGLDGNERHRKHIQMLHGLTDPLTFSTLNTEEAVADFDDRFKRAGAKAKIIERIVGETASPKSPERDSAEAAAGNIRVSGQKTKKGDDSMEDFVGSRFLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CKS5</accession>
    <name>A0A177CKS5_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">JmjC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CC84DRAFT_1163606</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG07450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037815.1">
        <property type="nucleotide sequence ID" value="XM_018178303.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CKS5"/>
    <dbReference type="STRING" id="1460663.A0A177CKS5"/>
    <dbReference type="GeneID" id="28761789"/>
    <dbReference type="InParanoid" id="A0A177CKS5"/>
    <dbReference type="OrthoDB" id="298344at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018866">
        <property type="entry name" value="Znf-4CXXC_R1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02373">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10497">
        <property type="entry name" value="zf-4CXXC_R1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="JmjC" evidence="6">
        <location>
            <begin position="177"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="554"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="721"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="872"/>
            <end position="1113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1149"/>
            <end position="1177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1190"/>
            <end position="1279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="796"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="806"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="872"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="960"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="997"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1007"/>
            <end position="1026"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="1073"/>
            <end position="1082"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1097"/>
            <end position="1113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1190"/>
            <end position="1206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1267"/>
            <end position="1279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAG07450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="1279" mass="144840" checksum="828B7F59A05FC9C3" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CL06</accession>
    <name>A0A177CL06_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">Kynureninase</fullName>
            <ecNumber evidence="4 5">3.7.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Biosynthesis of nicotinic acid protein 5</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">L-kynurenine hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BNA5</name>
        <name evidence="7" type="ORF">CC84DRAFT_1114522</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 5">Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>3-hydroxy-L-kynurenine + H2O = 3-hydroxyanthranilate + L-alanine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:25143"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:36559"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:58125"/>
            <dbReference type="EC" id="3.7.1.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4 5">
            <text>L-kynurenine + H2O = anthranilate + L-alanine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16813"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <dbReference type="ChEBI" id="CHEBI:57959"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="EC" id="3.7.1.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4 5">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4 5">Amino-acid degradation; L-kynurenine degradation; L-alanine and anthranilate from L-kynurenine: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 5">Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from L-kynurenine: step 2/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4 5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 5">Belongs to the kynureninase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.7.1.3" evidence="4 5"/>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038580.1">
        <property type="nucleotide sequence ID" value="XM_018175396.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CL06"/>
    <dbReference type="FunCoup" id="A0A177CL06">
        <property type="interactions" value="208"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CL06"/>
    <dbReference type="GeneID" id="28758882"/>
    <dbReference type="InParanoid" id="A0A177CL06"/>
    <dbReference type="OrthoDB" id="5978656at2759"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00329"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00334">
        <property type="reaction ID" value="UER00455"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030429">
        <property type="term" value="F:kynureninase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034354">
        <property type="term" value="P:'de novo' NAD+ biosynthetic process from L-tryptophan"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043420">
        <property type="term" value="P:anthranilate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097053">
        <property type="term" value="P:L-kynurenine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:L-tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019805">
        <property type="term" value="P:quinolinate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000031">
        <property type="entry name" value="Kynureninase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01970">
        <property type="entry name" value="Kynureninase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010111">
        <property type="entry name" value="Kynureninase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01814">
        <property type="entry name" value="kynureninase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14084">
        <property type="entry name" value="KYNURENINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14084:SF0">
        <property type="entry name" value="KYNURENINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22580">
        <property type="entry name" value="KYNU_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038800">
        <property type="entry name" value="KYNU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 4 5" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="3 4 5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotransferase class V" evidence="6">
        <location>
            <begin position="125"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="174"/>
            <end position="177"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="259"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="262"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="284"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="332"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="360"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="4">
        <location>
            <position position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR038800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAG08215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="499" mass="55458" checksum="91A638EF49F40BE4" modified="2016-09-07" version="1">MPQFSNPYAATSDQDLLSEAFARGEDARDPLSKLRAEFVIPTKGDLRNQRYGPAENATVSAGHVSRDDDHDESIYLCGNSLGLQPRRTREYVNRYLDTWASKGVFGHFKPLQGGLPPWLDLDDALKEQTATIVGALPSEVVVMETLTANLHLLMSSFYKPTSERYKIIIEGKAFPSDHYAAQSQLAHHGIPSSALITITPPSDDSPYLTTEHILSVISQHNATTALVLLPGIQFYSGQFFDIELITRHCHSLGIIVGWDLAHAVGNVPVKLHDWNVDFAAWCNYKYMNGGPGVIGGLFVHDNHGKVEKAQVDGDAEYNNDTQLHYRPRLSGWWGSDKSSRFRMENKFVPIPGASGFQLSNPSALDMTSVLASLDVFSMTSMEALRARSLRLTAYLEQRLLRYDNKTPPYKIITPANPAERGAQISVLLNPGLLDHVLHYIEEHGVVVDERKPDVLRVAPAPLYNSFWDVHRFIEIFQEGCRRAIVQKGKASAQTPNGVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CL21</accession>
    <name>A0A177CL21_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Histone transcription regulator 3 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_1114574</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Has a role in a nucleosome assembly pathway that is required for the integrity of heterochromatin and proper chromosome segregation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HIR3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038609.1">
        <property type="nucleotide sequence ID" value="XM_018175399.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A177CL21">
        <property type="interactions" value="125"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CL21"/>
    <dbReference type="GeneID" id="28758885"/>
    <dbReference type="InParanoid" id="A0A177CL21"/>
    <dbReference type="OrthoDB" id="77564at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000417">
        <property type="term" value="C:HIR complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033053">
        <property type="entry name" value="Hir3/CABIN1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15502">
        <property type="entry name" value="CALCINEURIN-BINDING PROTEIN CABIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15502:SF7">
        <property type="entry name" value="CALCINEURIN-BINDING PROTEIN CABIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="331"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="357"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="826"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1725"/>
            <end position="1756"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1783"/>
            <end position="1835"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1852"/>
            <end position="1996"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="629"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="370"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="391"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="827"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1737"/>
            <end position="1752"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="1785"/>
            <end position="1799"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1806"/>
            <end position="1815"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1883"/>
            <end position="1894"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="1910"/>
            <end position="1926"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1954"/>
            <end position="1963"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="1964"/>
            <end position="1988"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAG08244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="1996" mass="222624" checksum="037993BCAB3D70C3" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CLB0</accession>
    <name>A0A177CLB0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1214566</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038386.1">
        <property type="nucleotide sequence ID" value="XM_018182645.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CLB0"/>
    <dbReference type="GeneID" id="28766131"/>
    <dbReference type="InParanoid" id="A0A177CLB0"/>
    <dbReference type="OrthoDB" id="10475539at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG08021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="150" mass="17703" checksum="FC7C5EB3D34BCD01" modified="2016-09-07" version="1">MEPAEVMSKISKRRMPAEHAAEFEAFVDNLPNLPSPSSEYRHTLYAKHLPQWHGIKDWEFAPLRQAAVDYRKDGKWDADWKKLLLHEFYAREIRYIKKDPDFINARYGGQGYEGLYKDWTYQWSGGSWQPRHEEPIIRHDQIKEKAGGVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CLB1</accession>
    <name>A0A177CLB1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Rieske domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CC84DRAFT_1163843</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAD-dependent oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG07732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038097.1">
        <property type="nucleotide sequence ID" value="XM_018178349.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CLB1"/>
    <dbReference type="STRING" id="1460663.A0A177CLB1"/>
    <dbReference type="GeneID" id="28761835"/>
    <dbReference type="InParanoid" id="A0A177CLB1"/>
    <dbReference type="OrthoDB" id="6029at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03478">
        <property type="entry name" value="Rieske_AIFL_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="entry name" value="Rieske [2Fe-2S] iron-sulphur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050446">
        <property type="entry name" value="FAD-oxidoreductase/Apoptosis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028202">
        <property type="entry name" value="Reductase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43557">
        <property type="entry name" value="APOPTOSIS-INDUCING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43557:SF2">
        <property type="entry name" value="RIESKE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14759">
        <property type="entry name" value="Reductase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="FAD/NAD-linked reductases, dimerisation (C-terminal) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="ISP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="6" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rieske" evidence="10">
        <location>
            <begin position="7"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OAG07732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="548" mass="58484" checksum="DCB4E980EF14924D" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CNL9</accession>
    <name>A0A177CNL9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CC84DRAFT_1162332</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038722.1">
        <property type="nucleotide sequence ID" value="XM_018177962.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CNL9"/>
    <dbReference type="GeneID" id="28761448"/>
    <dbReference type="InParanoid" id="A0A177CNL9"/>
    <dbReference type="OrthoDB" id="6499973at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF230">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G12790)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="90"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="131"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="160"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="183"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="221"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="244"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="295"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="332"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="359"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="386"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="422"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="453"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="5">
        <location>
            <begin position="92"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="45"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAG08357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="486" mass="52917" checksum="D7F86BD68343E69F" modified="2016-09-07" version="1">MDSVANPAVQLQEMPAGGTTANEEPNMLEKAISRLSRRVAVQTEKSHLTTAAPMRERSSSRKSSVGGVIDEEIAEEADTENVFPEGGLRAWLVVAGATLMLLPSFGFMVSIGTLQDYWHQNQLSDFTARDIGWIPSVFVYLTLGLGLWVGPYFDRYGPRWIALVGSAGYVVMIFFLAECTEFWQMILCLGILGGVTAAMLTCTALAVVAQWFKTRRALAQGIAMAGNSVGGLAIPLILKSTFPAYGYAWSLRILGFVFLLCLVVSNILLKARFRPSAAAKKKAIISLHIFGDLRFSLFTISVFGFEVVLFGALGILPTYASISTDFPPNTGFYLIAVLNGVSCFGRVLPGYLGDKLGRFNTLLIMIVFTLVFMLALWLPLGTESLPALYAFSALFGFGTGSWMALTPACVGQLCRADEFGRYYGSMYFVASLATLVCIPISGELVQTVGPEAMVGFFCCILVLSLVSFIFSRWACLGRRWVLMAKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CP94</accession>
    <name>A0A177CP94_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Autophagy-related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CC84DRAFT_1194741</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11 12">Vacuolar effluxer which mediate the efflux of amino acids resulting from autophagic degradation. The release of autophagic amino acids allows the maintenance of protein synthesis and viability during nitrogen starvation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Vacuole membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the ATG22 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038962.1">
        <property type="nucleotide sequence ID" value="XM_018181365.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CP94"/>
    <dbReference type="FunCoup" id="A0A177CP94">
        <property type="interactions" value="27"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CP94"/>
    <dbReference type="GeneID" id="28764851"/>
    <dbReference type="InParanoid" id="A0A177CP94"/>
    <dbReference type="OrthoDB" id="192733at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032974">
        <property type="term" value="P:amino acid transmembrane export from vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17483">
        <property type="entry name" value="MFS_Atg22_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044738">
        <property type="entry name" value="Atg22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024671">
        <property type="entry name" value="Atg22-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050495">
        <property type="entry name" value="ATG22/LtaA_families"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23519">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23519:SF3">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 22-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11700">
        <property type="entry name" value="ATG22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="8 12" id="KW-0072">Autophagy</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <keyword evidence="4 12" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="31"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="143"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="167"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="251"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="283"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="356"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="392"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="423"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="459"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="527"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="202"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="555"/>
            <end position="579"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OAG08597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="579" mass="62790" checksum="957AA63D120B8ABB" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CPM5</accession>
    <name>A0A177CPM5_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CC84DRAFT_1085647</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bZIP family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039082.1">
        <property type="nucleotide sequence ID" value="XM_018174110.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CPM5"/>
    <dbReference type="STRING" id="1460663.A0A177CPM5"/>
    <dbReference type="GeneID" id="28757596"/>
    <dbReference type="InParanoid" id="A0A177CPM5"/>
    <dbReference type="OrthoDB" id="644067at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47416:SF8">
        <property type="entry name" value="BASIC-LEUCINE ZIPPER TRANSCRIPTION FACTOR E-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47416">
        <property type="entry name" value="BASIC-LEUCINE ZIPPER TRANSCRIPTION FACTOR F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="8">
        <location>
            <begin position="251"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="81"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="195"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="263"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="622"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="81"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="100"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="275"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAG08717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="644" mass="71565" checksum="8BD3EB48C7519BBF" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CQA7</accession>
    <name>A0A177CQA7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1162771</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039324.1">
        <property type="nucleotide sequence ID" value="XM_018178092.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CQA7"/>
    <dbReference type="STRING" id="1460663.A0A177CQA7"/>
    <dbReference type="GeneID" id="28761578"/>
    <dbReference type="InParanoid" id="A0A177CQA7"/>
    <dbReference type="OrthoDB" id="10249920at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080042">
        <property type="term" value="F:ADP-glucose pyrophosphohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080041">
        <property type="term" value="F:ADP-ribose pyrophosphohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006753">
        <property type="term" value="P:nucleoside phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019693">
        <property type="term" value="P:ribose phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03424">
        <property type="entry name" value="NUDIX_ADPRase_Nudt5_UGPPase_Nudt14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11839:SF18">
        <property type="entry name" value="NUDIX HYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11839">
        <property type="entry name" value="UDP/ADP-SUGAR PYROPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG08959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="293" mass="33779" checksum="AA14904A5FF7988D" modified="2016-09-07" version="1">MSKQFTLSDWNDIPVVVGLGVDNIDLDEKKLLKFPAFNGWQKTLRENLERQKRPGQVYSTDPWRLEKVMIHHVTLFGENIGFMTIEAFLRKGDGQALENRLDRVIFLRGGSVAVLMILRPKDNRNERYVILTDQPRLGACSTTFLEIPAGMLDEETRNIKGKAIQEIEEETNLQVRADELINLTELALRQSKAVEDLQQAIYMSPANLDEFIPLLLWEKELDRKDIMSMRSQLGGERTQGELITIRVTEYDTLWREGARDAKTLSAWALYEGLNRTGVIEKELQRIRSVNFDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CQI4</accession>
    <name>A0A177CQI4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Major myo-inositol transporter iolT</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CC84DRAFT_453520</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG09783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040148.1">
        <property type="nucleotide sequence ID" value="XM_018186330.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CQI4"/>
    <dbReference type="GeneID" id="28769816"/>
    <dbReference type="InParanoid" id="A0A177CQI4"/>
    <dbReference type="OrthoDB" id="6133115at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000117">
        <property type="entry name" value="MFS hexose transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF29">
        <property type="entry name" value="SUGAR TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G14500)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="83"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="138"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="293"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="335"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="359"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="464"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="35"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="487"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAG09783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="537" mass="60483" checksum="CC0A57A2F14E3671" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CQN5</accession>
    <name>A0A177CQN5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1171822</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG09210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039575.1">
        <property type="nucleotide sequence ID" value="XM_018179934.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CQN5"/>
    <dbReference type="GeneID" id="28763420"/>
    <dbReference type="InParanoid" id="A0A177CQN5"/>
    <dbReference type="OrthoDB" id="2142961at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016071">
        <property type="term" value="P:mRNA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028322">
        <property type="entry name" value="PNRC-like_rgn"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15365">
        <property type="entry name" value="PNRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="169"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="265"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="295"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="335"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="401"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="438"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG09210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="528" mass="55294" checksum="F13DF75CA3657603" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CR79</accession>
    <name>A0A177CR79_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GA4 desaturase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1235569</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the asaB hydroxylase/desaturase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG09721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040086.1">
        <property type="nucleotide sequence ID" value="XM_018183848.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CR79"/>
    <dbReference type="STRING" id="1460663.A0A177CR79"/>
    <dbReference type="GeneID" id="28767334"/>
    <dbReference type="InParanoid" id="A0A177CR79"/>
    <dbReference type="OrthoDB" id="412788at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044053">
        <property type="entry name" value="AsaB-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041278">
        <property type="entry name" value="CmcJ_NvfI_EfuI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34598">
        <property type="entry name" value="BLL6449 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34598:SF3">
        <property type="entry name" value="OXIDOREDUCTASE AN1597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG09721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="327" mass="36903" checksum="2AB4F0C79164771F" modified="2016-09-07" version="1">MPGLIGASSRGTVRYNVLDLSVRPEDRGLFSGPAHKYSEDIEVDLFEPVSSPEIVQGPEGLDVQGFAYVKHRSALDVDEWMNGENPEETYVKEVEDLVGKVTGAKKVVVNHLGIRKRLAEKNADPSFYRKAGDKHDETVKERAKKETAWVTGKTDAGLEPARFAHVDYTLEGLKRTARYCRKDIKAAAQEALDAEDANKDAKRYAAYSVWRPLKPVKRDPLAVADWRTTEKDTLQPIEYRATSNVVDKGEYMLEQYTQTPEAKNTGQKWYCMTKQTPEDVLILKFADTASEKDPKISQYCAHCSPMLPNVDNEEPRMSVEARVIAFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2023-06-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CRW6</accession>
    <name>A0A177CRW6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_476208</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040639.1">
        <property type="nucleotide sequence ID" value="XM_018186420.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CRW6"/>
    <dbReference type="GeneID" id="28769906"/>
    <dbReference type="InParanoid" id="A0A177CRW6"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG10274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="208" mass="22936" checksum="A3A97502AAFFDB9F" modified="2016-09-07" version="1">MTQMTSIENRPAAHTALASSTEIASRSGLAGEGNPPRWILAHPKRGSKTDPTCVCTRRTACATDVASIVSSGPWQTALIIASTPGANQCGYLLSCHRAVWFNKEAKRSSWLIAALCTIDVADPLSSSEINSATPQFAYHSPHTDEERRFPALRRHTMTRLSARSMALVVLRLWRNVPLLRKDKPNSPARVASQIVWLFRKNFNGRGRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2023-06-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CS79</accession>
    <name>A0A177CS79_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1235301</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG09619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039984.1">
        <property type="nucleotide sequence ID" value="XM_018183844.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CS79"/>
    <dbReference type="GeneID" id="28767330"/>
    <dbReference type="InParanoid" id="A0A177CS79"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG09619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="177" mass="18263" checksum="D9C561596037A202" modified="2016-09-07" version="1" fragment="single">AHSSPSRHPRSPSLPKRLASAGRVNIVVSRRSLIIVSDAEPVRRVRSEAEVGCEVTSTQRRGPNGCPGNAVACGLASIQGAIQHLRDRRRAGVVRRRVVIESLEAGVLELVEILPVGCGSLAEGCAGGRSHDRGRVSGVAWRLAEAAVSAASATESGKCPIGARAARLASPIGIASG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CSW2</accession>
    <name>A0A177CSW2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SGNH hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_461388</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040433.1">
        <property type="nucleotide sequence ID" value="XM_018186376.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CSW2"/>
    <dbReference type="GeneID" id="28769862"/>
    <dbReference type="InParanoid" id="A0A177CSW2"/>
    <dbReference type="OrthoDB" id="2119228at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004622">
        <property type="term" value="F:phosphatidylcholine lysophospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01833">
        <property type="entry name" value="XynB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051532">
        <property type="entry name" value="Ester_Hydrolysis_Enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30383:SF2">
        <property type="entry name" value="CELLULOSE-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30383">
        <property type="entry name" value="THIOESTERASE 1/PROTEASE 1/LYSOPHOSPHOLIPASE L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008058637" evidence="1">
        <location>
            <begin position="23"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="SGNH hydrolase-type esterase" evidence="2">
        <location>
            <begin position="88"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG10068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="255" mass="27587" checksum="685DAEE96D1C4630" modified="2016-09-07" version="1">MVRSTVLSSALGLLSLVSVGAAAPLDTRVDAANTVKVMPFGASIVEITCWRAYLWKKLQDSGITNIDFVGSHGTPAAGCTLNGQSVNFDKDNEGHSGAKVTDYANNNSLPPWLSAAKPDMIIMHVGTNDASANISTAKVFSAYDKLIGQMRAANPRTTLIASKLIPIDPNLFGQSVADKVKDYNYAMEGWVKRTTTAKSPIVLVDLNTGFDYKTMTREGEHPNEKGDVFMAEKLFPAVKDQLVELSVQKMMGEQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CT68</accession>
    <name>A0A177CT68_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Calcium-transporting ATPase</fullName>
            <ecNumber evidence="18">7.2.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">CC84DRAFT_1213342</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Catalyzes the hydrolysis of ATP coupled with the transport of calcium.</text>
    </comment>
    <comment type="function">
        <text evidence="17">This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. Transports the calcium to the vacuole and participates in the control of the cytosolic free calcium.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16 18">
            <text>Ca(2+)(in) + ATP + H2O = Ca(2+)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18105"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.2.2.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="18">Membrane</location>
            <topology evidence="18">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15 18">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.10" evidence="18"/>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG09967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040332.1">
        <property type="nucleotide sequence ID" value="XM_018182523.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A177CT68">
        <property type="interactions" value="464"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CT68"/>
    <dbReference type="GeneID" id="28766009"/>
    <dbReference type="InParanoid" id="A0A177CT68"/>
    <dbReference type="OrthoDB" id="3352408at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005388">
        <property type="term" value="F:P-type calcium transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02081">
        <property type="entry name" value="P-type_ATPase_Ca_PMCA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000039">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000028">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000031">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000018">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006408">
        <property type="entry name" value="P-type_ATPase_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01517">
        <property type="entry name" value="ATPase-IIB_Ca"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24093:SF369">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24093">
        <property type="entry name" value="CATION TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08282">
        <property type="entry name" value="Hydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 18" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 18" id="KW-0106">Calcium</keyword>
    <keyword evidence="4 18" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="13 18" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 18" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 18" id="KW-0813">Transport</keyword>
    <keyword evidence="3" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="297"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="334"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="501"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="542"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1002"/>
            <end position="1023"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1029"/>
            <end position="1052"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1073"/>
            <end position="1099"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1151"/>
            <end position="1171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1183"/>
            <end position="1204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1314"/>
            <end position="1335"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="20">
        <location>
            <begin position="196"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="234"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1271"/>
            <end position="1315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1333"/>
            <end position="1416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="65"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="90"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="119"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="234"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="1271"/>
            <end position="1287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="1338"/>
            <end position="1370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="1386"/>
            <end position="1396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="1405"/>
            <end position="1416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00038148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00059328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU361146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="OAG09967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="1416" mass="153327" checksum="9C0DFA78D90AD0FA" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CTQ9</accession>
    <name>A0A177CTQ9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1194024</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041031.1">
        <property type="nucleotide sequence ID" value="XM_018181336.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CTQ9"/>
    <dbReference type="STRING" id="1460663.A0A177CTQ9"/>
    <dbReference type="GeneID" id="28764822"/>
    <dbReference type="InParanoid" id="A0A177CTQ9"/>
    <dbReference type="OrthoDB" id="3057599at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021840">
        <property type="entry name" value="DUF3433"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37544:SF1">
        <property type="entry name" value="PHOSPHORIBOSYLAMINOIMIDAZOLE-SUCCINOCARBOXAMIDE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37544">
        <property type="entry name" value="SPRAY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11915">
        <property type="entry name" value="DUF3433"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="258"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="301"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="369"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="409"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="563"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="610"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="681"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="719"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="202"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="805"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="22"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="805"/>
            <end position="829"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG10666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="879" mass="99647" checksum="C3922B1B41C31ED4" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CTZ3</accession>
    <name>A0A177CTZ3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF1996 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1184654</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041081.1">
        <property type="nucleotide sequence ID" value="XM_018180765.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CTZ3"/>
    <dbReference type="GeneID" id="28764251"/>
    <dbReference type="InParanoid" id="A0A177CTZ3"/>
    <dbReference type="OrthoDB" id="74764at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018535">
        <property type="entry name" value="DUF1996"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43662">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43662:SF4">
        <property type="entry name" value="DUF1996 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09362">
        <property type="entry name" value="DUF1996"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1996" evidence="1">
        <location>
            <begin position="15"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG10716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="327" mass="35355" checksum="1CBF160DBD9B1FD7" modified="2016-09-07" version="1">MLRFACSQLVVERTDPLVNPGMKYTPHLHQIVGGNSFNVSMDPNNDPAKLSTCTSCSFVQDKSNYWTAVMFFHHKNGSYIRVPQTGNGGPQGKLINKGGLDVYYIPSGKTTAFKKGFRMLAGSATNTDDNKVSKGNICHRCWTSPNENTFVGAQPCSGTDTVAIPSDPKCKMIRQTIIFPTCWDGKNLDSPDHQSHVAYGQGSGASGGGACPSTHPVKLPQVMYELMWNVTNFSDKSQWPTDGSKPFVYSMNLGGAAAHGDYVFGWEGDSLQKAMDNGCNLNNACPKAGLTTQSDAQYSACTKQQQAPEDVDGWLKALPMGDMAIKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CUN4</accession>
    <name>A0A177CUN4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Mediator of RNA polymerase II transcription subunit 8</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Mediator complex subunit 8</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">MED8</name>
        <name evidence="3" type="ORF">CC84DRAFT_1203091</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the Mediator complex subunit 8 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041093.1">
        <property type="nucleotide sequence ID" value="XM_018181805.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CUN4"/>
    <dbReference type="GeneID" id="28765291"/>
    <dbReference type="InParanoid" id="A0A177CUN4"/>
    <dbReference type="OrthoDB" id="5329317at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019364">
        <property type="entry name" value="Mediatior_Med8_fun/met"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10232">
        <property type="entry name" value="Med8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0010">Activator</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="140"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="191"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="147"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="228"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU364144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG10728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="257" mass="28602" checksum="D9625A8991A64967" modified="2016-09-07" version="1">MASNTNQAPPGEPAKADIALLESLRTRLMSLVWILEQMKKELMANPTAPPDWPTIQRSISAVSNTITSIQSFINKDPETHSTFRALHSFPIPPFPAANESLGTIIEAILSKEPGAKEKDWILDKIIKAAEFAHVPSDWDIQAKPPVDEQDEDMDEGGEGSLKLRRQKANLDEDQLADLWRDVYDIVNEVAKVSNQNQEEDDSSASGDEEDEEMEDVLETGTPVQGVGGEKEKKVKEEQPMMSLDTIHRFMSTGSTFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CUN6</accession>
    <name>A0A177CUN6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Aspartyl proteinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CC84DRAFT_1210930</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG11254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041619.1">
        <property type="nucleotide sequence ID" value="XM_018182332.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CUN6"/>
    <dbReference type="FunCoup" id="A0A177CUN6">
        <property type="interactions" value="416"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CUN6"/>
    <dbReference type="GeneID" id="28765818"/>
    <dbReference type="InParanoid" id="A0A177CUN6"/>
    <dbReference type="OrthoDB" id="771136at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097718">
        <property type="term" value="F:disordered domain specific binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070492">
        <property type="term" value="F:oligosaccharide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016237">
        <property type="term" value="P:microautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000425">
        <property type="term" value="P:pexophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd05488">
        <property type="entry name" value="Proteinase_A_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000036">
        <property type="entry name" value="Vacuolar aspartic protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000002">
        <property type="entry name" value="Vacuolar aspartic proteinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033819">
        <property type="entry name" value="Saccharopepsin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF51">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="8 11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 12" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0926">Vacuole</keyword>
    <feature type="domain" description="Peptidase A1" evidence="13">
        <location>
            <begin position="63"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="81"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="264"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="94"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="298"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OAG11254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="375" mass="40797" checksum="0F1368414510D93D" modified="2016-09-07" version="1">MKLKKVPLSEQLQHASFQEQAKALGQKYMGIKTESHMEQVFKAPYVADGTHPVPITNFLNAQYFSEVSLGTPPQDFKVILDTGSSNLWVPSSECSSIACYLHTKYDSSASSTYKKNGSSFEIRYGSGSLSGFVSQDTFQIGDLKVKNQDFAEATSEPGLAFAFGRFDGILGLGYDTISVNKIVPPFYNMLDQGLLDEPVFAFYLGDANGGADSEAIFGGVNEDHYTGKLTKLPLRRKAYWEVDLDAITFGDETAEMDNTGVILDTGTSLIALPSTIAELLNKEIGAKKGFNGQYTVECDKVDSLPDLTFTLTGHNFTIGAHDYVLEVQGSCISAFMGMDFPEPVGPLAILGDAFLRRWYSVYDLGNSAVGLAKAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CUU0</accession>
    <name>A0A177CUU0_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Altered inheritance of mitochondria protein 11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">AIM11</name>
        <name evidence="6" type="ORF">CC84DRAFT_1184604</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the AIM11 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041005.1">
        <property type="nucleotide sequence ID" value="XM_018180761.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CUU0"/>
    <dbReference type="FunCoup" id="A0A177CUU0">
        <property type="interactions" value="19"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CUU0"/>
    <dbReference type="GeneID" id="28764247"/>
    <dbReference type="InParanoid" id="A0A177CUU0"/>
    <dbReference type="OrthoDB" id="3558022at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038814">
        <property type="entry name" value="AIM11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39136">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39136:SF1">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="35"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="9"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAG10640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="169" mass="18579" checksum="01BBEDBA52C1DCD7" modified="2016-09-07" version="1">MTRSTAPPVNAPPRPPPEPAYESTPITSERSLRQLSIFAFGAASFLAATAITRRAVYKRHLRVKPTFYAPNTNPHEHFSPLHDAAQALNLATMHCVSLATMGLGGTMWAFDIANLQEARQRLRGRLNYDTIYQPGDAVPDSIMDLLVAAQETASTEDETNNSDTPEKSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CUZ6</accession>
    <name>A0A177CUZ6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1200641</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG11343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041708.1">
        <property type="nucleotide sequence ID" value="XM_018181675.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CUZ6"/>
    <dbReference type="GeneID" id="28765161"/>
    <dbReference type="InParanoid" id="A0A177CUZ6"/>
    <dbReference type="OrthoDB" id="5151921at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG11343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="275" mass="30253" checksum="E2FBFA4FC606F722" modified="2016-09-07" version="1">MTKPKSRTISAPFDARHVGGVSIPGATVPIVGIERSSTSLEPDNAPSHTFVAHGNIEVPRRSHTIASTLGRPSLTLKTSISLLRGRSNSNAQAPEPTDGSLKGEMSVHSLRKKTSTSRFWQKAHHESPVAESPKEDKGAMRAFPPHKETPVLRTKPSHPFMPSLPTANPYVYQAPPVPSPPPPPASELRQTPPQRAPTQKKLPVVRSKRADSGTAIDFDDVPAEERPLGFREILAVSSFSERMALYKKTRDYWAHADHGLVEWVDRSRPRPSFRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CVB6</accession>
    <name>A0A177CVB6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_1085065</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041175.1">
        <property type="nucleotide sequence ID" value="XM_018174082.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CVB6"/>
    <dbReference type="STRING" id="1460663.A0A177CVB6"/>
    <dbReference type="GeneID" id="28757568"/>
    <dbReference type="InParanoid" id="A0A177CVB6"/>
    <dbReference type="OrthoDB" id="5376138at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000088">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF3">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="187"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="294"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="324"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="374"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="400"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="444"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="474"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="65"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAG10810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="528" mass="59862" checksum="135B226E2171DE05" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CVZ1</accession>
    <name>A0A177CVZ1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Phosphoribosyl pyrophosphokinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CC84DRAFT_42435</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ribose-phosphate pyrophosphokinase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG11693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042058.1">
        <property type="nucleotide sequence ID" value="XM_018186175.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CVZ1"/>
    <dbReference type="FunCoup" id="A0A177CVZ1">
        <property type="interactions" value="205"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CVZ1"/>
    <dbReference type="GeneID" id="28769661"/>
    <dbReference type="InParanoid" id="A0A177CVZ1"/>
    <dbReference type="OrthoDB" id="413572at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097268">
        <property type="term" value="C:cytoophidium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002189">
        <property type="term" value="C:ribose phosphate diphosphokinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004749">
        <property type="term" value="F:ribose phosphate diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006015">
        <property type="term" value="P:5-phosphoribose 1-diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000063">
        <property type="entry name" value="Phosphoribosylpyrophosphate synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000030">
        <property type="entry name" value="Ribose-phosphate pyrophosphokinase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000047">
        <property type="entry name" value="Ribose-phosphate pyrophosphokinase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029099">
        <property type="entry name" value="Pribosyltran_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005946">
        <property type="entry name" value="Rib-P_diPkinase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01251">
        <property type="entry name" value="ribP_PPkin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210">
        <property type="entry name" value="RIBOSE-PHOSPHATE DIPHOSPHOKINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210:SF36">
        <property type="entry name" value="RIBOSE-PHOSPHATE PYROPHOSPHOKINASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14572">
        <property type="entry name" value="Pribosyl_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13793">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01400">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ribose-phosphate pyrophosphokinase N-terminal" evidence="4">
        <location>
            <begin position="6"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="112"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="159"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="159"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="185"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAG11693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="436" mass="47212" checksum="FB70879B83EB2A95" modified="2016-09-07" version="1">MVRNIVVLGGSSHPQLTQQICDHLGIPPAKRLLSKFAVGETRVEVEESVRGKDVFIVQSGGGKVNDNLMELLICISACRTASAKRITAVLPLFPYSRQSDIPYNKTGAPLAKVPGANRSRTGTYSFDSVPATPHPAHPGATLTNGTASLDKSLERLKMSEERTPSHGLKRTDTVETKKSDGSDKGSFQANGVNGTHGNNGLARAATMPPQFSPQPGYKQWVAQAGTLIADLLTCAGADHVITMDLHDPQYQGFFDIPVDNLYGRHLLRKYIQFSIPNYQQAVIVSPDAGGAKRATAIADALGMPFALIHKERRPTQISDRQNATMMLVGEIRDRTAILIDDLADTSNTITRAAKLLKKEGANTVYALITHGILSGDAIDRINASALDKVVVTNTVDQTEHKARCPKLEVLEVGNVFAEAIRRVHHGESISVLFDYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CW43</accession>
    <name>A0A177CW43_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Bacterial low temperature requirement A protein-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1256732</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG11027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041392.1">
        <property type="nucleotide sequence ID" value="XM_018184651.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CW43"/>
    <dbReference type="STRING" id="1460663.A0A177CW43"/>
    <dbReference type="GeneID" id="28768137"/>
    <dbReference type="InParanoid" id="A0A177CW43"/>
    <dbReference type="OrthoDB" id="191995at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010640">
        <property type="entry name" value="Low_temperature_requirement_A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36840">
        <property type="entry name" value="BLL5714 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36840:SF1">
        <property type="entry name" value="BLL5714 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06772">
        <property type="entry name" value="LtrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="274"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="300"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="328"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="358"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="412"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="435"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="480"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="532"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="570"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="600"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="11"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG11027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="672" mass="75698" checksum="23B00A92F040C0F0" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CWW8</accession>
    <name>A0A177CWW8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CC84DRAFT_1211197</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG11538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041903.1">
        <property type="nucleotide sequence ID" value="XM_018182356.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CWW8"/>
    <dbReference type="GeneID" id="28765842"/>
    <dbReference type="InParanoid" id="A0A177CWW8"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF45">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="65"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="99"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="123"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="157"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="190"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="278"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="317"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="344"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="379"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="443"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="17"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAG11538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="517" mass="56562" checksum="6E2DB77C5EEF7C81" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CX00</accession>
    <name>A0A177CX00_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NACHT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_47160</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG11731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042096.1">
        <property type="nucleotide sequence ID" value="XM_018186412.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CX00"/>
    <dbReference type="STRING" id="1460663.A0A177CX00"/>
    <dbReference type="GeneID" id="28769898"/>
    <dbReference type="InParanoid" id="A0A177CX00"/>
    <dbReference type="OrthoDB" id="674604at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF17">
        <property type="entry name" value="FUNGAL STAND N-TERMINAL GOODBYE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50837">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="NACHT" evidence="3">
        <location>
            <begin position="201"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="2">
        <location>
            <begin position="745"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="773"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAG11731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="773" mass="86836" checksum="2E5148EB5B160213" modified="2016-09-07" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CX49</accession>
    <name>A0A177CX49_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CC84DRAFT_1253792</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG11299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041664.1">
        <property type="nucleotide sequence ID" value="XM_018184404.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CX49"/>
    <dbReference type="STRING" id="1460663.A0A177CX49"/>
    <dbReference type="GeneID" id="28767890"/>
    <dbReference type="InParanoid" id="A0A177CX49"/>
    <dbReference type="OrthoDB" id="4337792at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="8"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="85"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="47"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="54"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAG11299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="616" mass="69280" checksum="250C5303C606B8EA" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CXQ5</accession>
    <name>A0A177CXQ5_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CC84DRAFT_1254064</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG11630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041995.1">
        <property type="nucleotide sequence ID" value="XM_018184434.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CXQ5"/>
    <dbReference type="STRING" id="1460663.A0A177CXQ5"/>
    <dbReference type="GeneID" id="28767920"/>
    <dbReference type="InParanoid" id="A0A177CXQ5"/>
    <dbReference type="OrthoDB" id="5391602at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF134">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="41"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="127"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="176"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="211"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="253"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="25"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="327"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAG11630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="376" mass="41856" checksum="A01F945141534BE5" modified="2016-09-07" version="1">MSTNAAGLYILCSVLPALSTIAVGARLYVRNLKKQKFGVDDGTALAGLIGLWGVAGVILDGTRRGLFGGNSDLDPITGALIRSWREGPNVKYSWIVPIVTVVALAPIKLSVIFLYRRVFHISRFFHYYSIFLGVLLVAWAIAFMFASIFQCGTKPWAYWTTVQTIKLFCGDTGGANVALCFSDLFIDILILIAPLVMIWKMKFSMWRKMQIVGVFALGFVSTAAAATRVYIMWEDAYDTKRGHTNLIRENTKVVMWCLIEISSALIACCLPVLRPIFANTWVSRLLCKIQSRVCPEYSSNAPSDRQLEEGMAFRSIGGTDFNVVKRDSMSRKDSKMSTNVESREIDPTGDMEKSTGEIDTMFKEIDVSKEVAIEQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CY42</accession>
    <name>A0A177CY42_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1211728</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042486.1">
        <property type="nucleotide sequence ID" value="XM_018182398.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CY42"/>
    <dbReference type="STRING" id="1460663.A0A177CY42"/>
    <dbReference type="GeneID" id="28765884"/>
    <dbReference type="InParanoid" id="A0A177CY42"/>
    <dbReference type="OrthoDB" id="2153847at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008058736" evidence="1">
        <location>
            <begin position="19"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG12121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="105" mass="10621" checksum="77CEA03B8D86E81F" modified="2016-09-07" version="1">MKFTTSLALFSAVALTNALAIRQSNAQTFTGALGGIAATPIEDSGDAKRPFSVKGDTFVNLGAAVQRSCDQQFNACANLANGGSQSVAFADCTAQKNQCDAAGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CY49</accession>
    <name>A0A177CY49_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">TauD-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_1183111</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TfdA dioxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042828.1">
        <property type="nucleotide sequence ID" value="XM_018180665.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CY49"/>
    <dbReference type="STRING" id="1460663.A0A177CY49"/>
    <dbReference type="GeneID" id="28764151"/>
    <dbReference type="InParanoid" id="A0A177CY49"/>
    <dbReference type="OrthoDB" id="10257314at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016706">
        <property type="term" value="F:2-oxoglutarate-dependent dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.130.10:FF:000003">
        <property type="entry name" value="Alpha-ketoglutarate-dependent taurine dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051323">
        <property type="entry name" value="AtsK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT SULFONATE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468:SF28">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT TAURINE DIOXYGENASE (AFU_ORTHOLOGUE AFUA_8G02210)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="7">
        <location>
            <begin position="79"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAG12463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="370" mass="41383" checksum="898E3ADB236C8C34" modified="2016-09-07" version="1">MATVTQVQEATNADGQPIKLAVAYSDEVHNQAKYAAYLPVYDTTTKFPPTPLFDHDDRGRHADPAKPNLLSKENPQIKVNKLTPRVGTEITGLQLSELTDIQKDELALLIAERGVVVFRDQDFKDIGPEKQKEFGEYFGRVHVHPVGAHVKNHIEFHSIYLGKDNLYRLGRSSSKLTTTGYHSDVSYEHQPPGITLLTLLQVPSTGGDTGWTSQAAAYERLSEPLKHFLEGLRAEHSGFPQADRAARDGHFVRRDPVKSYHPIVRVHPVTGQKVLFVNPGFTKRIVGLKDEESDAILKLLFKHIAQSQDIQARVKWDDRTVALWDNRVTAHTAISDYDVSDEAEGLRQGFRITTLGEVPVGVNGLKSEWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CYN4</accession>
    <name>A0A177CYN4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Clavaminate synthase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CC84DRAFT_1227233</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018043029.1">
        <property type="nucleotide sequence ID" value="XM_018183605.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CYN4"/>
    <dbReference type="STRING" id="1460663.A0A177CYN4"/>
    <dbReference type="GeneID" id="28767091"/>
    <dbReference type="InParanoid" id="A0A177CYN4"/>
    <dbReference type="OrthoDB" id="406156at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044283">
        <property type="term" value="P:small molecule biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050295">
        <property type="entry name" value="Plant_2OG-oxidoreductases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47991">
        <property type="entry name" value="OXOGLUTARATE/IRON-DEPENDENT DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00682">
        <property type="entry name" value="IPNSYNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="5">
        <location>
            <begin position="205"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAG12664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="401" mass="45933" checksum="FEC2438BD0417ECA" modified="2016-09-07" version="1">MAPTAPFNPPAADLPGKPFVPEWIPPPVTQQKENFAELSSIDLSLLDSEDPAVVDGLVQRVKRAIRDEGFLFLENYGISLEQLHRQFAIAQYLYNNITEEDKERLLFNPETGVWSGYKHPYGFKRHRGCADGIEQFNWYKPDWESMDRSPTCVHPFMDEIRAFCEYLTQSVNRRLLTLFSRVLELPDDYLWDNVQSHGGPTGEGYFRHALFRPVQKSTEEASKGLRMHGHTDFGLTTLLFSVPISCLQIWGQDEKWYYVPYKPGALVINIGDTLEIVSGGHFKATRHRVFKPPVDQLQQERLSLVLFNSSLGDMRMSPAYDSPLIQREGCVEEQGIYKEFKKRTSGGDLAPTNRQWREIQIATATDPTDTEHNRVGVHQSIIDGKLMHTREYMGMRVVLPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CZP2</accession>
    <name>A0A177CZP2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CC84DRAFT_1160032</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018043141.1">
        <property type="nucleotide sequence ID" value="XM_018177385.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CZP2"/>
    <dbReference type="GeneID" id="28760871"/>
    <dbReference type="InParanoid" id="A0A177CZP2"/>
    <dbReference type="OrthoDB" id="5415072at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031632">
        <property type="entry name" value="SVIP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15811">
        <property type="entry name" value="SVIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="1" id="KW-0519">Myristate</keyword>
    <keyword evidence="2" id="KW-0564">Palmitate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="46"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="61"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="80"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="101"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAG12776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="119" mass="12200" checksum="D8CE2C36565D4251" modified="2016-09-07" version="1">MGNLCGKSSKDDNFQGAGRTLNAAPAPATKASIPASAKPKVTGPGRTVGGPGGSDGANDPRAAAAAAAEARANKPVTGDLAKKLEEQKKQTRNQTLQQAADENRLQREADAATETRNYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CZX4</accession>
    <name>A0A177CZX4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CC84DRAFT_1212345</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">ATP-dependent RNA helicase involved spliceosome assembly and in nuclear splicing. Catalyzes an ATP-dependent conformational change of U2 snRNP. Bridges U1 and U2 snRNPs and enables stable U2 snRNP association with intron RNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the DEAD box helicase family. DDX46/PRP5 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018043221.1">
        <property type="nucleotide sequence ID" value="XM_018182443.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CZX4"/>
    <dbReference type="FunCoup" id="A0A177CZX4">
        <property type="interactions" value="1016"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CZX4"/>
    <dbReference type="GeneID" id="28765929"/>
    <dbReference type="InParanoid" id="A0A177CZX4"/>
    <dbReference type="OrthoDB" id="196131at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990446">
        <property type="term" value="F:U1 snRNP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990447">
        <property type="term" value="F:U2 snRNP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903241">
        <property type="term" value="P:U2-type prespliceosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000079">
        <property type="entry name" value="probable ATP-dependent RNA helicase DDX17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056149">
        <property type="entry name" value="PRP5/DDX46/KHDC4_KH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23469">
        <property type="entry name" value="KH_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="17">
        <location>
            <begin position="489"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="15">
        <location>
            <begin position="520"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="16">
        <location>
            <begin position="729"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="246"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="13">
        <location>
            <begin position="489"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="131"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="174"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="214"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="315"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="341"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00037330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="OAG12856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="1126" mass="124388" checksum="62349BD123BF0BF4" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177D106</accession>
    <name>A0A177D106_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_155616</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018043064.1">
        <property type="nucleotide sequence ID" value="XM_018185396.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177D106"/>
    <dbReference type="GeneID" id="28768882"/>
    <dbReference type="InParanoid" id="A0A177D106"/>
    <dbReference type="OrthoDB" id="10575353at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG12699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="122" mass="13068" checksum="92B821C0303CDB36" modified="2016-09-07" version="1">MAVLYRAGHCAGGDADAHGRSELSLSQSTLAGCRHEARRLLRACATAFWSLPPEAVMMDRSLCNSFEDAVIPIMACIIGGPPHRPQEAMMNADERGATAAGGKNKLIHGHSLGHEFLIPLFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BV76</accession>
    <name>A0A177BV76_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">MFS transporter-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CC84DRAFT_1169760</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441563">
        <property type="protein sequence ID" value="OAF99055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029421.1">
        <property type="nucleotide sequence ID" value="XM_018179750.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BV76"/>
    <dbReference type="FunCoup" id="A0A177BV76">
        <property type="interactions" value="139"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177BV76"/>
    <dbReference type="GeneID" id="28763236"/>
    <dbReference type="InParanoid" id="A0A177BV76"/>
    <dbReference type="OrthoDB" id="10027823at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23520">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G04000)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23520:SF5">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G04000)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="90"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="154"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="192"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="324"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="363"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="4">
        <location>
            <begin position="10"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="471"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="471"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="482"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="501"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAF99055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="513" mass="55580" checksum="356D901E788D4F67" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BVF2</accession>
    <name>A0A177BVF2_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">dynamin GTPase</fullName>
            <ecNumber evidence="2">3.6.5.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CC84DRAFT_1181844</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.5"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.5" evidence="2"/>
    <dbReference type="EMBL" id="KV441563">
        <property type="protein sequence ID" value="OAF99135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029501.1">
        <property type="nucleotide sequence ID" value="XM_018180574.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BVF2"/>
    <dbReference type="FunCoup" id="A0A177BVF2">
        <property type="interactions" value="1311"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177BVF2"/>
    <dbReference type="GeneID" id="28764060"/>
    <dbReference type="InParanoid" id="A0A177BVF2"/>
    <dbReference type="OrthoDB" id="5061070at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034643">
        <property type="term" value="P:establishment of mitochondrion localization, microtubule-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015886">
        <property type="term" value="P:heme transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048312">
        <property type="term" value="P:intracellular distribution of mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097753">
        <property type="term" value="P:membrane bending"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090149">
        <property type="term" value="P:mitochondrial membrane fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000001">
        <property type="term" value="P:mitochondrion inheritance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016559">
        <property type="term" value="P:peroxisome fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051260">
        <property type="term" value="P:protein homooligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140572">
        <property type="term" value="P:vacuole fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016050">
        <property type="term" value="P:vesicle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd08771">
        <property type="entry name" value="DLP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1240:FF:000002">
        <property type="entry name" value="Dynamin-1-like protein isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1240:FF:000022">
        <property type="entry name" value="Dynamin-like GTPase Dnm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000383">
        <property type="entry name" value="Dynamin-like gtpase dnm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1240">
        <property type="entry name" value="Dynamin, middle domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022812">
        <property type="entry name" value="Dynamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001401">
        <property type="entry name" value="Dynamin_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019762">
        <property type="entry name" value="Dynamin_GTPase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000375">
        <property type="entry name" value="Dynamin_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030381">
        <property type="entry name" value="G_DYNAMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003130">
        <property type="entry name" value="GED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020850">
        <property type="entry name" value="GED_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566">
        <property type="entry name" value="DYNAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566:SF235">
        <property type="entry name" value="DYNAMIN-RELATED PROTEIN DNM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01031">
        <property type="entry name" value="Dynamin_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02212">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00195">
        <property type="entry name" value="DYNAMIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00053">
        <property type="entry name" value="DYNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00302">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00410">
        <property type="entry name" value="G_DYNAMIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51718">
        <property type="entry name" value="G_DYNAMIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51388">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="4 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynamin-type G" evidence="14">
        <location>
            <begin position="27"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="GED" evidence="13">
        <location>
            <begin position="719"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="533"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="642"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="533"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="655"/>
            <end position="668"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OAF99135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="806" mass="89574" checksum="EA2DA6D3CE5F626F" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BVG6</accession>
    <name>A0A177BVG6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1170011</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441565">
        <property type="protein sequence ID" value="OAF98648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029014.1">
        <property type="nucleotide sequence ID" value="XM_018179810.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BVG6"/>
    <dbReference type="GeneID" id="28763296"/>
    <dbReference type="InParanoid" id="A0A177BVG6"/>
    <dbReference type="OrthoDB" id="4775599at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="177"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="250"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAF98648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="282" mass="31132" checksum="4DF814C89F5880D0" modified="2016-09-07" version="1">MYARAAHETTNLQLMRSDMLSGSISGFISLPSSLLSLIALLPMSASGQRATAATPSIPTMLSRTEHTQSMTTSYMSSPVSNTTAAATSTSTPISNDILPGATNARDPTASAFRYYWLILVVFGLVIALFLWWINRRRIKRKELMRLSGRNALARDMEGWVNTRRWYHGAWRPNDIRASTRREEGFNENGEAPPPYRPKGDVTVTQDPATGLSIPLRTLSREQVDAGHPPEYHETLNRHSDDATRPAMADSGTNLHATTDSPPRSSIGDLVHVHYDRGTTAQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BVV6</accession>
    <name>A0A177BVV6_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Asl1-like glycosyl hydrolase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1169764</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441563">
        <property type="protein sequence ID" value="OAF99060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029426.1">
        <property type="nucleotide sequence ID" value="XM_018179752.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BVV6"/>
    <dbReference type="STRING" id="1460663.A0A177BVV6"/>
    <dbReference type="GeneID" id="28763238"/>
    <dbReference type="InParanoid" id="A0A177BVV6"/>
    <dbReference type="OrthoDB" id="43654at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071966">
        <property type="term" value="P:fungal-type cell wall polysaccharide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053183">
        <property type="entry name" value="ASL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024655">
        <property type="entry name" value="Asl1_glyco_hydro_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34154">
        <property type="entry name" value="ALKALI-SENSITIVE LINKAGE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34154:SF3">
        <property type="entry name" value="ALKALI-SENSITIVE LINKAGE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11790">
        <property type="entry name" value="Glyco_hydro_cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Asl1-like glycosyl hydrolase catalytic" evidence="1">
        <location>
            <begin position="27"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAF99060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="246" mass="28466" checksum="ACBF6FDC22C0D608" modified="2016-09-07" version="1">MVIKKRSLLWDYTNTNNLAGRMDTVNFDGPISSVSNWNAWVPPELKGRAPFRPMIHLERELNGNEWQWILDSDQPIIHFFNEPERNGISPQKAADYWHNQVIPALRNDRHKQLVSPSCASDPAGQQWIADFMNLVGDARPDYLGLHWYGVEASECQQFISSMHDKFGLPVIVSEIASIDRNYDSVHAFTRDMCNWMDGVDWIFEYAFFGCMQNMPDDFVSPAARLMDEGGNFTDLMWKYMSDQPMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BW83</accession>
    <name>A0A177BW83_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_394076</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441562">
        <property type="protein sequence ID" value="OAF99385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029751.1">
        <property type="nucleotide sequence ID" value="XM_018186041.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BW83"/>
    <dbReference type="FunCoup" id="A0A177BW83">
        <property type="interactions" value="85"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177BW83"/>
    <dbReference type="GeneID" id="28769527"/>
    <dbReference type="InParanoid" id="A0A177BW83"/>
    <dbReference type="OrthoDB" id="3026777at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507:SF40">
        <property type="entry name" value="TETRACYCLINE-EFFLUX TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507">
        <property type="entry name" value="ZGC:174356"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="164"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="226"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="261"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="296"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="380"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="424"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="463"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="486"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="520"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="549"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="97"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="30"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="30"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="64"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAF99385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="602" mass="65924" checksum="74DE66604A8641EE" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BX13</accession>
    <name>A0A177BX13_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Zinc/iron permease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CC84DRAFT_1191206</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441562">
        <property type="protein sequence ID" value="OAF99228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029594.1">
        <property type="nucleotide sequence ID" value="XM_018181172.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BX13"/>
    <dbReference type="FunCoup" id="A0A177BX13">
        <property type="interactions" value="28"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177BX13"/>
    <dbReference type="GeneID" id="28764658"/>
    <dbReference type="InParanoid" id="A0A177BX13"/>
    <dbReference type="OrthoDB" id="262547at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040:SF210">
        <property type="entry name" value="ZINC-REGULATED TRANSPORTER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040">
        <property type="entry name" value="ZINC/IRON TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="359"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="389"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="428"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="461"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="119"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="261"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="129"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="148"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="271"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="301"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAF99228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="481" mass="51425" checksum="CBCED2E03D4E28FB" modified="2016-09-07" version="1">MGLDNDARGWIMAAVSGIASIICVDLVIRLLPGKKNFKIEESNIFLSTGLSLSFGVMIFSALYSMLPSARNYLTKGGLSPKVATLVLIASFMVGALGIAVVSQVLHRFIPHSVVDCDHDHGDEEEGKADDDHAGHDHSPSSSRPMEEQWNSVLENSHSSYGGTDHHGFPARRPSLHTQISTKVTQLVTGSKEFCDENGKCFGYSDPCGNECFRNVQHDRVPRFHSASTKIPTRPSGSRTQTLPAERQPLLQSITNLQALDENTPLAPTVSGPATTETTSHTNPSPIHANGNGTPRPLTKQSSHSSLVSHASATHHHHVPTNAFLSIGLQTSIAIALHKIPEGFITYATNHANPRLGVSIFLALFIHNITEGFAMALPLYLAINSRVKAMFWSTILGGVSQPLGAGVAALWFKIAKRRAGEGEGEPGELVYGVMFGVTAGIMAMVSLQLLGESLELTHSRKLCFASAFAGMGILGVSSALTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BYA6</accession>
    <name>A0A177BYA6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1168843</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441560">
        <property type="protein sequence ID" value="OAF99930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030296.1">
        <property type="nucleotide sequence ID" value="XM_018179498.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BYA6"/>
    <dbReference type="STRING" id="1460663.A0A177BYA6"/>
    <dbReference type="GeneID" id="28762984"/>
    <dbReference type="InParanoid" id="A0A177BYA6"/>
    <dbReference type="OrthoDB" id="3801445at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008057533" evidence="2">
        <location>
            <begin position="20"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="229"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="235"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="258"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="286"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="359"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="372"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="460"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAF99930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="479" mass="41380" checksum="687E58734CE9BB18" modified="2016-09-07" version="1">MKFSASVVAALAATPLVAAAPAPFPKTEKKWVDTNSGFTGTKIPAHFVSSFRKIAREKAMGKRQLDQLLGQLTGGAGGAGGNAAGGAGGLEGLLGGLTGGAAGGNAAGGAAGAGGLGGLLGGLTGGAAGGNAAGGAAGGAGGLDALLGGLTGGAAGGNAATGSAGAAGAATTGAAGKGKAGKGKAGAATPAAGAAATNGTASAVGAAKGKGKKGKAGAAGATAGNGAGTAGAAGVGAAKNGTAAATGTAAGKGKGKGKGNGAAGTAGAGTAGAGTKGTQGTGAQTGTGSTTGTAGTGTAAQLGNGQTGTQGTQGTQGTQGTQGTQGTQGTQGGSNAANSGSTQTGQAGIQGAGSATGQTGTGSTTGNGGSVQAGQQGTGSTTGQTNTGSTAANGGSTQAGQSGLQGTQGGSTAAKGGSTQAGQVGQQGAGLTNGQTSTGSTAANSGSSVSGGSAAGAGAGSSAITSQGAADDAGDNGDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BZ07</accession>
    <name>A0A177BZ07_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HECT-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CC84DRAFT_1222269</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPL family. K-HECT subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="3"/>
    <dbReference type="EMBL" id="KV441560">
        <property type="protein sequence ID" value="OAF99928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030294.1">
        <property type="nucleotide sequence ID" value="XM_018183348.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A177BZ07">
        <property type="interactions" value="1191"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177BZ07"/>
    <dbReference type="GeneID" id="28766834"/>
    <dbReference type="InParanoid" id="A0A177BZ07"/>
    <dbReference type="OrthoDB" id="423283at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00078">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045322">
        <property type="entry name" value="HECTD1/TRIP12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057948">
        <property type="entry name" value="TPR_TRIP12_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45670:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE HECTD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45670">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TRIP12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25579">
        <property type="entry name" value="TPR_TRIP12_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="HECT" evidence="8">
        <location>
            <begin position="1482"/>
            <end position="1837"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="735"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1043"/>
            <end position="1198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1280"/>
            <end position="1309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="8"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="21"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="50"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="199"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="737"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="750"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1078"/>
            <end position="1087"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="1100"/>
            <end position="1110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1113"/>
            <end position="1128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="1144"/>
            <end position="1154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1288"/>
            <end position="1298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1299"/>
            <end position="1309"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="6">
        <location>
            <position position="1804"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAF99928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="1837" mass="201175" checksum="8000D7E100CF4A3C" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BZF7</accession>
    <name>A0A177BZF7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1168880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441560">
        <property type="protein sequence ID" value="OAF99971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030337.1">
        <property type="nucleotide sequence ID" value="XM_018179508.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BZF7"/>
    <dbReference type="GeneID" id="28762994"/>
    <dbReference type="InParanoid" id="A0A177BZF7"/>
    <dbReference type="OrthoDB" id="10423909at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAF99971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="248" mass="27493" checksum="7AA46B633F8EDB22" modified="2016-09-07" version="1">MSPQHASTHGVSDADVNVYDPQPRPESQEERTGEGFAEQESVDERDAIAQDARSEHDGNRERQLTQEEQGKDGGQAPKKRGLFSKRKGGTKHRDATPLSNLSTSGHRDGLPSNPFSVTVANSFTTFPPPPRVAQHATRMEQRRAHRECDAERAPSMKLDGSKGPGHGQNLVQRAISIAEWEDDGKEDHIAGSRHFHDVQRHPAARRLNAIGRDMFEGGNGHIDAQFSRISPEYAAQIAVNRARLDRIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C0X7</accession>
    <name>A0A177C0X7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1102017</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441559">
        <property type="protein sequence ID" value="OAG00458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030823.1">
        <property type="nucleotide sequence ID" value="XM_018174942.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C0X7"/>
    <dbReference type="STRING" id="1460663.A0A177C0X7"/>
    <dbReference type="GeneID" id="28758428"/>
    <dbReference type="InParanoid" id="A0A177C0X7"/>
    <dbReference type="OrthoDB" id="5420724at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42069">
        <property type="entry name" value="HYPHAL ANASTAMOSIS-8 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42069:SF1">
        <property type="entry name" value="MARVEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="153"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="194"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="230"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="296"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="350"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="406"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="359"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG00458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="496" mass="55028" checksum="527439232C2BDA6B" modified="2016-09-07" version="1">MATNDKKNPTVTIEKRKSGDSLAPPTKSPRAARFAEATSVYSPIDPPQRPLEYPTNHYQPQAQVSDVGFGYVQPIEMEETDRKYLPPPTPKTPLRSALKSPGAPPRTPGAETMILSPTFREEQILEKREQSTDKEQQKDLVLRVRVAKIFLRGINFACSLIVLSMLATAFSIFNATKHLPMRNGLPPWAENQKIWPQVLLLCIACVSLFFSIFVLVAYSRGGHNRAEKVAAYYTVFAVGFFIFSIIMWAVGAAAFNQSKAQGGNKDMWGWSCVDNKRRHLFEDDVSYALMCRLQNWSLVCCIIEVVVETLCIIIYAIVFYRFWSKRKLRKSMAMRDKARSDLYLAQLRSQSAPNTPGFGPLSPRSGGWRPPPGHPQYYDPQSAAENGDADKVQYAYAREIAQPQPFTLGAPPIKVTGATPHIEQNGFDAPARTQTSSPPASPGFQERQNDHVGAVPGEQQYASVPIPGAYQPLASPSHPQQATPGFDFGPNVTGPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C1F2</accession>
    <name>A0A177C1F2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CC84DRAFT_1168225</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441558">
        <property type="protein sequence ID" value="OAG01041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031406.1">
        <property type="nucleotide sequence ID" value="XM_018179344.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C1F2"/>
    <dbReference type="STRING" id="1460663.A0A177C1F2"/>
    <dbReference type="GeneID" id="28762830"/>
    <dbReference type="InParanoid" id="A0A177C1F2"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43963">
        <property type="entry name" value="CARBONYL REDUCTASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43963:SF6">
        <property type="entry name" value="CHAIN DEHYDROGENASE FAMILY PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G15350)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="140"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAG01041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="167" mass="17635" checksum="AD063D31E01A145B" modified="2016-09-07" version="1">MSSPKVIIVTGANRGIGCAICTSLLSHPSQISHPITLFATSRQGSNLNLTTSSSNQRNLYPSLDITSSSSISTFVLKLKSSYGNVEVLINNAGVNLDSDFPPSNARKPLDTNYRGTLDVCTAILPLLTPKTGRIVNLSSAGSSLDPFNPPSPSASEPCPRLKTSTSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C1I8</accession>
    <name>A0A177C1I8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1209435</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441559">
        <property type="protein sequence ID" value="OAG00480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030845.1">
        <property type="nucleotide sequence ID" value="XM_018182220.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C1I8"/>
    <dbReference type="GeneID" id="28765706"/>
    <dbReference type="InParanoid" id="A0A177C1I8"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG00480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="188" mass="21347" checksum="7E665139668E163D" modified="2016-09-07" version="1">MPKSGGRRSATLHEWGTPLTRNARHVLILKVQSDIINTSISWFTSDDIVDKITDDEPQSAELQILPHRSTTPVSSESTSAATANRDLTTSARRREAPYHRRASSKKQLSRFQRRHGFPALIWFPPLRVHWPYPRPTAAFQLQDPILVSTRTKNHQTFDVASSNIRAARALSTALSLRDHRSYTAYRPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C1R8</accession>
    <name>A0A177C1R8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Putative mitochondrial F1F0-ATP synthase g subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CC84DRAFT_1168018</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATPase g subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441558">
        <property type="protein sequence ID" value="OAG00782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031147.1">
        <property type="nucleotide sequence ID" value="XM_018179307.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C1R8"/>
    <dbReference type="FunCoup" id="A0A177C1R8">
        <property type="interactions" value="75"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177C1R8"/>
    <dbReference type="GeneID" id="28762793"/>
    <dbReference type="InParanoid" id="A0A177C1R8"/>
    <dbReference type="OrthoDB" id="437at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015078">
        <property type="term" value="F:proton transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015986">
        <property type="term" value="P:proton motive force-driven ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006808">
        <property type="entry name" value="ATP_synth_F0_gsu_mt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12386">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04718">
        <property type="entry name" value="ATP-synt_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="4" id="KW-0138">CF(0)</keyword>
    <keyword evidence="5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="26"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="41"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OAG00782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="202" mass="21000" checksum="16168F31BE8BDB18" modified="2016-09-07" version="1">MSLAASRQVLRQSTFAVRRAGLRNASTTSEAAGAAKEKAAEASSKASEGLTRVTSSASAAAAKVGSAATNAANKVGGRTGRLIGGVQALIPRVIYYSRVGLELGKLVAHQRGMAPPNMATIQQYLQPVTNALKNPSSLLNVSKAAESSSAQPVNMLNRVRGASQQQWLAAGIIAAEVVGFFSVGEIIGRFKLVGYRSKEAHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C255</accession>
    <name>A0A177C255_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">histone acetyltransferase</fullName>
            <ecNumber evidence="3">2.3.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CC84DRAFT_1101523</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acetyltransferase family. GCN5 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="3"/>
    <dbReference type="EMBL" id="KV441558">
        <property type="protein sequence ID" value="OAG00817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031182.1">
        <property type="nucleotide sequence ID" value="XM_018174918.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C255"/>
    <dbReference type="FunCoup" id="A0A177C255">
        <property type="interactions" value="422"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177C255"/>
    <dbReference type="GeneID" id="28758404"/>
    <dbReference type="InParanoid" id="A0A177C255"/>
    <dbReference type="OrthoDB" id="1937912at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140671">
        <property type="term" value="C:ADA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000775">
        <property type="term" value="C:chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046695">
        <property type="term" value="C:SLIK (SAGA-like) complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140068">
        <property type="term" value="F:histone crotonyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036408">
        <property type="term" value="F:histone H3K14 acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043993">
        <property type="term" value="F:histone H3K18 acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140129">
        <property type="term" value="F:histone H3K56ac reader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043992">
        <property type="term" value="F:histone H3K9 acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140011">
        <property type="term" value="F:histone H4K12ac reader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140046">
        <property type="term" value="F:histone H4K16ac reader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010515">
        <property type="term" value="P:negative regulation of induction of conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045815">
        <property type="term" value="P:transcription initiation-coupled chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd05509">
        <property type="entry name" value="Bromo_gcn5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000004">
        <property type="entry name" value="Histone acetyltransferase KAT2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018359">
        <property type="entry name" value="Bromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037800">
        <property type="entry name" value="GCN5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45750">
        <property type="entry name" value="GH11602P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45750:SF3">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00633">
        <property type="entry name" value="BROMODOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0010">Activator</keyword>
    <keyword evidence="11" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7 12" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="5" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4 16" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="15">
        <location>
            <begin position="120"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="14">
        <location>
            <begin position="362"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="22"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="60"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OAG00817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="462" mass="52725" checksum="D7CE079324B3BA89" modified="2016-09-07" version="1">MSARENSDRLRTTLGYASSSPPKLPTSPPFSSPDTLRDTPPKAPEAPSPSTSPDIPLSRLRARHSRPTLPKRKAAAPLNPESPSKRPKQDSETPEAPPQPKKLIPFPEKPAVIEEREGDIEFRVVNNDGKRESTIILTGLKCIFQKQLPKMPKDYIARLVYDRTHLSIAIVKKPLEVVGGITYRPFHGRQFAEIVFCAISSDQQVKGYGAHLMSHLKDYVKATSDVMHFLTYADNYAIGYFKKQGFTKEITLEKSRWMGYIKDYEGGTIMQCSMVPKIRYLESGRMLLKQKECVNVKIRSVSKSFEVHAPPPQWKNSLTKIDPLTIAAIKRSGWSPAMDELARAPRHGPNYNQLLHLLNDLQNNSNAWPFQQPVNKDEVLDYYDVIKEPMDLATMEEKHEKDLYPTPEDFVRDAKLIFDNCRKYNNESTPYAKAANRLEKYMWSRIREIPEWAHLEADYGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C273</accession>
    <name>A0A177C273_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Amino acid transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CC84DRAFT_1251774</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441556">
        <property type="protein sequence ID" value="OAG01884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032249.1">
        <property type="nucleotide sequence ID" value="XM_018184339.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C273"/>
    <dbReference type="FunCoup" id="A0A177C273">
        <property type="interactions" value="13"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177C273"/>
    <dbReference type="GeneID" id="28767825"/>
    <dbReference type="InParanoid" id="A0A177C273"/>
    <dbReference type="OrthoDB" id="3900342at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF23">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="96"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="141"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="190"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="221"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="265"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="306"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="354"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="403"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="429"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="464"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="500"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAG01884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="553" mass="59819" checksum="802A643A7E82FCC3" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C2B7</accession>
    <name>A0A177C2B7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Short-chain dehydrogenase/reductase-like protein SDR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CC84DRAFT_1168015</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441558">
        <property type="protein sequence ID" value="OAG00780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031145.1">
        <property type="nucleotide sequence ID" value="XM_018179305.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C2B7"/>
    <dbReference type="STRING" id="1460663.A0A177C2B7"/>
    <dbReference type="GeneID" id="28762791"/>
    <dbReference type="InParanoid" id="A0A177C2B7"/>
    <dbReference type="OrthoDB" id="417891at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019301">
        <property type="term" value="P:rhamnose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000417">
        <property type="entry name" value="Glucose 1-dehydrogenase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760:SF83">
        <property type="entry name" value="(3R)-3-HYDROXYACYL-COA DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASES/REDUCTASES FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0684">Rhamnose metabolism</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAG00780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="270" mass="28217" checksum="C739EB0E04FB847B" modified="2016-09-07" version="1">MSNPAQLLKGKSTAITGGVTGIGRAIALAYLAHGANIAVNHFGDAKSADQYQTLLEEAASILGSKEEAEKRLAEVSGDVGNPETGKRLVAEVVKRWGRLDVVVSNAGICEFKEFLDITPQLWATTHDANLTGAFNTIHAAATQMSTQSPPGGSVIGISSISALVGGAQQAHYTPTKAGVLSLIQSAACALGKHNIRCNALLPGTIKTQLNEKDLADDEKRKYMEGRIPLGRTGEPRDLAGPAVFLASDELSGYVTGAQLLVDGGLFVNLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C2G2</accession>
    <name>A0A177C2G2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Isochorismatase hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_186605</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the isochorismatase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441557">
        <property type="protein sequence ID" value="OAG01341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031706.1">
        <property type="nucleotide sequence ID" value="XM_018185517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C2G2"/>
    <dbReference type="STRING" id="1460663.A0A177C2G2"/>
    <dbReference type="GeneID" id="28769003"/>
    <dbReference type="InParanoid" id="A0A177C2G2"/>
    <dbReference type="OrthoDB" id="245563at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="entry name" value="Isochorismatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050272">
        <property type="entry name" value="Isochorismatase-like_hydrls"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43540:SF15">
        <property type="entry name" value="BLR5631 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43540">
        <property type="entry name" value="PEROXYUREIDOACRYLATE/UREIDOACRYLATE AMIDOHYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="Isochorismatase-like hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase-like" evidence="3">
        <location>
            <begin position="22"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAG01341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="192" mass="20447" checksum="3FA5B434F74D5DA1" modified="2016-09-07" version="1">MATKSFRDLLGVPPSTASTSDSALIIIDAQNEYASGALTVTNAESSGKAIADLLEKYRKAGGKIIHVLHKTPEGAPIFTPGTELAEEFKALKAKDGETTIWKQFPGAFKETDLNETLQGWGVKKVVLTGYMAHVCVSTTAREAYQSGYDVILVEDGIGDRDIPGVKGDEVTRVALAELGDVFGTVVKSSDIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C2H3</accession>
    <name>A0A177C2H3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Methyltransferas-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_276194</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441558">
        <property type="protein sequence ID" value="OAG01062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031427.1">
        <property type="nucleotide sequence ID" value="XM_018185717.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C2H3"/>
    <dbReference type="STRING" id="1460663.A0A177C2H3"/>
    <dbReference type="GeneID" id="28769203"/>
    <dbReference type="InParanoid" id="A0A177C2H3"/>
    <dbReference type="OrthoDB" id="3647at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43861:SF1">
        <property type="entry name" value="TRANS-ACONITATE 2-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43861">
        <property type="entry name" value="TRANS-ACONITATE 2-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase" evidence="3">
        <location>
            <begin position="46"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAG01062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="253" mass="28104" checksum="48FEF3D100EC9288" modified="2016-09-07" version="1">MSTADQVKEDYHKHAETYGGYNVLPAGVLESQIIKNALGDATGLVILDLGGGSGIHAREAIDAGAQRVDIVDISPEMMKVATDTEKSLGRDGRIRTFEGDVSKPMDHLPLETYDVVMANWVFDHAGTVEVLEGMWQNVVKYLKPGAKFLGIHAEDPRRPSLNGKYGVRNSNFREIPGGIAYTVEMLNDPPWKFEGTSLEISFSGSFELHEKYALENVSVVPYDNTEAVKQDPEFWKLFLEHPFYAVVQGFKKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C2T8</accession>
    <name>A0A177C2T8_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">GPI inositol-deacylase</fullName>
            <ecNumber evidence="12">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CC84DRAFT_1209129</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 12">Involved in inositol deacylation of GPI-anchored proteins which plays important roles in the quality control and ER-associated degradation of GPI-anchored proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the GPI inositol-deacylase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="12"/>
    <dbReference type="EMBL" id="KV441558">
        <property type="protein sequence ID" value="OAG01057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031422.1">
        <property type="nucleotide sequence ID" value="XM_018182201.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C2T8"/>
    <dbReference type="FunCoup" id="A0A177C2T8">
        <property type="interactions" value="43"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177C2T8"/>
    <dbReference type="GeneID" id="28765687"/>
    <dbReference type="InParanoid" id="A0A177C2T8"/>
    <dbReference type="OrthoDB" id="348976at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050185">
        <property type="term" value="F:phosphatidylinositol deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006505">
        <property type="term" value="P:GPI anchor metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000056">
        <property type="entry name" value="GPI inositol-deacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012908">
        <property type="entry name" value="PGAP1-ab_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039529">
        <property type="entry name" value="PGAP1/BST1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056824">
        <property type="entry name" value="PGAP1_TMD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15495:SF7">
        <property type="entry name" value="GPI INOSITOL-DEACYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15495">
        <property type="entry name" value="NEGATIVE REGULATOR OF VESICLE FORMATION-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07819">
        <property type="entry name" value="PGAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25141">
        <property type="entry name" value="PGAP1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25140">
        <property type="entry name" value="PGAP1_TMD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="692"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="786"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="861"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="903"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="935"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="965"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="989"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="domain" description="GPI inositol-deacylase PGAP1-like alpha/beta" evidence="13">
        <location>
            <begin position="105"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="GPI inositol-deacylase transmembrane" evidence="14">
        <location>
            <begin position="699"/>
            <end position="1007"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU365011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF07819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF25140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OAG01057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="1034" mass="115112" checksum="3408786F776BF9EC" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C2U4</accession>
    <name>A0A177C2U4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">AA9 family lytic polysaccharide monooxygenase</fullName>
            <ecNumber evidence="5">1.14.99.56</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Endo-beta-1,4-glucanase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Glycosyl hydrolase 61 family protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_1100329</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Lytic polysaccharide monooxygenase (LMPO) that depolymerizes crystalline and amorphous polysaccharides via the oxidation of scissile alpha- or beta-(1-4)-glycosidic bonds, yielding C1 and/or C4 oxidation products. Catalysis by LPMOs requires the reduction of the active-site copper from Cu(II) to Cu(I) by a reducing agent and H(2)O(2) or O(2) as a cosubstrate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>[(1-&gt;4)-beta-D-glucosyl]n+m + reduced acceptor + O2 = 4-dehydro-beta-D-glucosyl-[(1-&gt;4)-beta-D-glucosyl]n-1 + [(1-&gt;4)-beta-D-glucosyl]m + acceptor + H2O.</text>
            <dbReference type="EC" id="1.14.99.56"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 5">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="5">Has a modular structure: an endo-beta-1,4-glucanase catalytic module at the N-terminus, a linker rich in serines and threonines, and a C-terminal carbohydrate-binding module (CBM).</text>
    </comment>
    <dbReference type="EC" id="1.14.99.56" evidence="5"/>
    <dbReference type="EMBL" id="KV441557">
        <property type="protein sequence ID" value="OAG01756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032121.1">
        <property type="nucleotide sequence ID" value="XM_018174859.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C2U4"/>
    <dbReference type="STRING" id="1460663.A0A177C2U4"/>
    <dbReference type="GeneID" id="28758345"/>
    <dbReference type="InParanoid" id="A0A177C2U4"/>
    <dbReference type="OrthoDB" id="5271017at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008810">
        <property type="term" value="F:cellulase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030248">
        <property type="term" value="F:cellulose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd21175">
        <property type="entry name" value="LPMO_AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049892">
        <property type="entry name" value="AA9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005103">
        <property type="entry name" value="AA9_LPMO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353:SF3">
        <property type="entry name" value="ENDOGLUCANASE II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03443">
        <property type="entry name" value="AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="4 5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008057714" description="AA9 family lytic polysaccharide monooxygenase" evidence="6">
        <location>
            <begin position="17"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="Auxiliary Activity family 9 catalytic" evidence="7">
        <location>
            <begin position="25"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU368122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAG01756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="220" mass="23403" checksum="B650031CACA36632" modified="2016-09-07" version="1">MKTFALLLAAASAVSAHYTLPTINGAPAWSAVRQAKNWQNNGFVGDVTSSDIRCNQLYAGNETVSVAAGSSVKVNVNPNAYHPGPFQSYLAKVPEGQDVNKWDPTGAVWFRIYAEQPKFGSQLTWLSAANYDIKIPSCIPAGKYLMRNEHIGLHVAQSSGGAQFYLSCAQIEVTGGGSKTPTNLAAFPGAYKASDPGILININYPVPTSYVNPGPATFTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C443</accession>
    <name>A0A177C443_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1221139</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441557">
        <property type="protein sequence ID" value="OAG01652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032017.1">
        <property type="nucleotide sequence ID" value="XM_018183232.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C443"/>
    <dbReference type="GeneID" id="28766718"/>
    <dbReference type="InParanoid" id="A0A177C443"/>
    <dbReference type="OrthoDB" id="3782369at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="66"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG01652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="220" mass="25057" checksum="D838456A4626C463" modified="2016-09-07" version="1">MRFHHLDRLKFSFHHQLQAPHSVMRGAFRDKFAFELFIEKTWNAIQSCITELATGTWLEYFVLDPVGQYVAVAAIALILSLCVGRFHILLNAWKMVVNKAFARIKDDNANHSGYGACDSDKPTAAGDEDSPNDVQNKQEAAKLANRLENVHIATRKTTSSLAPHFRPQQNPNMLIEPDANTVSVLKYQTPPRRPDLMTTEGDPETIKKRKDQLDRLRMWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C4C0</accession>
    <name>A0A177C4C0_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CC84DRAFT_1167349</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Forms homooligomers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SHO1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441556">
        <property type="protein sequence ID" value="OAG02256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032621.1">
        <property type="nucleotide sequence ID" value="XM_018179163.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C4C0"/>
    <dbReference type="FunCoup" id="A0A177C4C0">
        <property type="interactions" value="125"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177C4C0"/>
    <dbReference type="GeneID" id="28762649"/>
    <dbReference type="InParanoid" id="A0A177C4C0"/>
    <dbReference type="OrthoDB" id="5983572at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007232">
        <property type="term" value="P:osmosensory signaling pathway via Sho1 osmosensor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11855">
        <property type="entry name" value="SH3_Sho1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000213">
        <property type="entry name" value="High osmolarity signaling protein SHO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035522">
        <property type="entry name" value="Sho1_SH3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="8" id="KW-0346">Stress response</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="37"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="99"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="13">
        <location>
            <begin position="255"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="172"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="209"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="173"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="216"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="239"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OAG02256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="314" mass="33741" checksum="AA5860574CBAA8FF" modified="2016-09-07" version="1">MPQYGTYGSPSLNKMENGYGHGGRSSFSLGRIFGDPFALATISIGSLAWVIAFVSSILSALRPKPEERVPPFAWWTLVYMLCSIVGVSVTVASDSERTYHVAIVGFTAAGIVLSSSAVNALVYSPVAANEAAAAGFILLSMIAIVWVFYYGSQPQASHRTFVDSYALHKEQPASRSSRQMSNTYGAPQQSSLAPQPQLYTSAQLNGFETSSPVSGYPGGPVGGDARGSSIPRFGGGMGQTPTNDVEQQPQEQSIEYPYRAKAIYSYEANPDDANEISFQKHDILEVSDVSGRWWQAKKPNGETGIAPSNYLILL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C4E2</accession>
    <name>A0A177C4E2_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1051733</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441556">
        <property type="protein sequence ID" value="OAG02031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032396.1">
        <property type="nucleotide sequence ID" value="XM_018173489.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C4E2"/>
    <dbReference type="GeneID" id="28756975"/>
    <dbReference type="InParanoid" id="A0A177C4E2"/>
    <dbReference type="OrthoDB" id="3205825at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35179:SF1">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35179">
        <property type="entry name" value="PROTEIN CBG02620"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="186"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG02031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="237" mass="27435" checksum="6D3436479D18AEED" modified="2016-09-07" version="1" fragment="single">ITVAGVVFGLSMCFAICAAYIALQQTKNSRRPSKSVYVWMIWIELAACVTIAIECLLYLLYVIPPSFYFFMSILLLWSVQIHLLLQIIINRIRIILYDRTKGRAMVIGVASIILCINISVFCIWIPARLQISNRYIRINNIWDRLEKVIYLLIDACLNWYFIHIVKQSLVANGLQKYNRLVRFNQRIIVVSLLMDVMIIGAMSIPNGFLYAMFHPLAFLVKLNIEMIMANLIRRIAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C4R7</accession>
    <name>A0A177C4R7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Capsule polysaccharide biosynthesis protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1167937</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441557">
        <property type="protein sequence ID" value="OAG01788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032153.1">
        <property type="nucleotide sequence ID" value="XM_018179289.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C4R7"/>
    <dbReference type="GeneID" id="28762775"/>
    <dbReference type="InParanoid" id="A0A177C4R7"/>
    <dbReference type="OrthoDB" id="409543at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008441">
        <property type="entry name" value="AfumC-like_glycosyl_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05704">
        <property type="entry name" value="Caps_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG01788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="408" mass="46459" checksum="EE2656055E1A3B9B" modified="2016-09-07" version="1">MQYPPISGTSSLPYDPWPPIDLNKLPSSLSSPELPKPHSKSKSIFAFWMTGIHTLPPYLLRNVIAWHRRYNPLGWTVYIVDTVPNSPLNVSRFIDVTSPSVVPDAFREGNLDGGYAAQHTSDLVRFPLLLRYGGVYMDVGVLHFGNLDSLWTTRIANTNSPFDFAGFTMGEPPEISAVNFWLMSTPDNPLIERAHYILLKLWKGKTNTKGASKHPLVSHVPLMRVPQEVTVEEEDKDNMVIDDAAMTDYAVQIQCLGAAQRWLDEQDGWNGPQYVREKCWFYSMIDHTYVHEQLTNWTSKKQHELFSISLPGAKEKESEDQKLARTIVEKAIAESWCMKLGHSFSAKLFGADTLGMWWRKHDGTDCKEGTYGGWLRWAEVNCNQDHAPKPLEIPPYEPTMKGRLFEFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C5R3</accession>
    <name>A0A177C5R3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1219798</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG02855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033220.1">
        <property type="nucleotide sequence ID" value="XM_018183111.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C5R3"/>
    <dbReference type="GeneID" id="28766597"/>
    <dbReference type="InParanoid" id="A0A177C5R3"/>
    <dbReference type="OrthoDB" id="3801583at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="428"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="223"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="242"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="260"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG02855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="592" mass="63086" checksum="545F062B16A972C5" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C5W6</accession>
    <name>A0A177C5W6_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Acyclic terpene utilisation N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1198468</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441556">
        <property type="protein sequence ID" value="OAG02272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032637.1">
        <property type="nucleotide sequence ID" value="XM_018181568.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C5W6"/>
    <dbReference type="STRING" id="1460663.A0A177C5W6"/>
    <dbReference type="GeneID" id="28765054"/>
    <dbReference type="InParanoid" id="A0A177C5W6"/>
    <dbReference type="OrthoDB" id="10265871at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010839">
        <property type="entry name" value="AtuA_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47585">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47585:SF2">
        <property type="entry name" value="DUF1446 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G11420)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07287">
        <property type="entry name" value="AtuA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyclic terpene utilisation N-terminal" evidence="1">
        <location>
            <begin position="22"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="Acyclic terpene utilisation N-terminal" evidence="1">
        <location>
            <begin position="202"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG02272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="446" mass="50049" checksum="B9B312B73EFA8172" modified="2016-09-07" version="1">MTLHGAQKVENEELRLEGNLLEEPAGLFDPTVLENLAPALPDIARKGFKAAVNAGACDTQLLAKVVADEIARQNLNLKVAYVEGDTKINKFVSFITGENLKDCGYTLKRLQCYLGGASIAEALNNGADIVFCGRVAKAAPSVGVGLWWHGWNREKDFDQIAGSLICGHLIESCPEGVVMAEEGKPLVRVTGVRGLPHPPLRKTWIERQVRYSAGDAIKELSSFKFSVNGYRPDVTRNQNVATCDVRIFFQTKNKKLVDKSTLHVPGFNRRCMDNGLQGYPGWTLGIDQRQSEGKVNYEYTVSLFPQSEVQHHVVLPWLENKTIDILPPKDMKLYPRQSNYEIKDVVDLRTFGPTTRGAMGWVVGCHSGGNASDANVDFYVRNDDEWGWLRSFLTIRKTKLMLDEEDHLDRGFNSTSTYDTLGKNFGEYLRAKWVDTLNRFLERGRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C6C9</accession>
    <name>A0A177C6C9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1219992</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG03085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033450.1">
        <property type="nucleotide sequence ID" value="XM_018183124.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C6C9"/>
    <dbReference type="STRING" id="1460663.A0A177C6C9"/>
    <dbReference type="GeneID" id="28766610"/>
    <dbReference type="InParanoid" id="A0A177C6C9"/>
    <dbReference type="OrthoDB" id="5422613at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38167">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38167:SF1">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG03085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="180" mass="20601" checksum="DFD038FDB29FE0E1" modified="2016-09-07" version="1">MAETKRASELLGAIQAATPDRLREVLTALCLEQRATFTATYQKLLVDESQQLDVGDSEDDASASEAELPPKRRFPMPEGPAPQLGNKRKRYEVCKQCDKEYDSLVNTKTSCIYHDGELEVDWEGDIWADHDERCHGTINTEAMRKEYPEGFLWSCCDRFGDKTGCRKGPHRPQEAKRRRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C6N6</accession>
    <name>A0A177C6N6_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Chitin-binding type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CC84DRAFT_1151376</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG03066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033431.1">
        <property type="nucleotide sequence ID" value="XM_018176744.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C6N6"/>
    <dbReference type="STRING" id="1460663.A0A177C6N6"/>
    <dbReference type="GeneID" id="28760230"/>
    <dbReference type="InParanoid" id="A0A177C6N6"/>
    <dbReference type="OrthoDB" id="1193027at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11618">
        <property type="entry name" value="ChtBD1_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.10">
        <property type="entry name" value="Endochitinase-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001002">
        <property type="entry name" value="Chitin-bd_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036861">
        <property type="entry name" value="Endochitinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003609">
        <property type="entry name" value="Pan_app"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46471">
        <property type="entry name" value="CHITIN DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46471:SF2">
        <property type="entry name" value="CHITIN DEACETYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00187">
        <property type="entry name" value="Chitin_bind_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00270">
        <property type="entry name" value="ChtBD1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57016">
        <property type="entry name" value="Plant lectins/antimicrobial peptides"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50941">
        <property type="entry name" value="CHIT_BIND_I_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50948">
        <property type="entry name" value="PAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2 8" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="7" id="KW-0170">Cobalt</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008057821" description="Chitin-binding type-1 domain-containing protein" evidence="10">
        <location>
            <begin position="21"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-1" evidence="11">
        <location>
            <begin position="29"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-1" evidence="11">
        <location>
            <begin position="89"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-1" evidence="11">
        <location>
            <begin position="164"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="12">
        <location>
            <begin position="340"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="292"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="48"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="108"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="188"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OAG03066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="431" mass="43183" checksum="DD8C94564A351793" modified="2016-09-07" version="1">MPSIATWALAALAAVQVAHAAPQRSVSHTARCGANFGLTCKGSSFGNCCSKAGWCGSSKDYCGDGCQSGWGTCNSSGGNKPVGPKVSKNGSCGQNGGTTCLGSSFGNCCSQHGYCGSSKNYCGKGCNPLFGKCDGYQPAQSSTPVVVSSAPVASPSSAIPVSHNARCGTKNNASPKGQTCRGSSFGNCCSQYGYCGSSKDYCRTGCQSQFGHCDGQPVSSPIRSSVVSTPAASSPASSSAIVSTPAASSSIISSVVASSDSSSTSVVSTPAVSSSIVVPSPTLVSSDVASSAVPSSSVDSSSTPVVSSSASSDIPSVVSSTPVASPTCTPAPDFQPSGTCNYPGFPRNANAAATYLMTQGTTLDGCKQLCFNSEPCQYFVMQGSSCYLYNRPVSGNGDLVPDSSVRLYERSCFPPPGACFSEGPASSSSTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C7B7</accession>
    <name>A0A177C7B7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1178279</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG02668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033033.1">
        <property type="nucleotide sequence ID" value="XM_018180329.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C7B7"/>
    <dbReference type="GeneID" id="28763815"/>
    <dbReference type="InParanoid" id="A0A177C7B7"/>
    <dbReference type="OrthoDB" id="10597168at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG02668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="201" mass="22066" checksum="23A2A0B3B7D8F5C7" modified="2016-09-07" version="1">MRPGPPSGVLAAEAMSVDTAGSAGQDCANAEVVRLMHDDSTEASGRTSDAPDKCAHCSQPCGETIMRPPRGYAMVTQKRSPTTCFSMAVLQSVFWPPESQSASSVRYRIRLRLVQIECSTNNYLIRSQFLASQEPCLVHVHFFRGPVRALQMPSFPHSRPAGFPLRESHVPVNECVKLMSELCCNGGTVYERAIHVADRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C855</accession>
    <name>A0A177C855_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1188329</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG03735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034100.1">
        <property type="nucleotide sequence ID" value="XM_018180982.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C855"/>
    <dbReference type="STRING" id="1460663.A0A177C855"/>
    <dbReference type="GeneID" id="28764468"/>
    <dbReference type="InParanoid" id="A0A177C855"/>
    <dbReference type="OrthoDB" id="4850at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37948:SF1">
        <property type="entry name" value="BLL5189 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37948">
        <property type="entry name" value="ZGC:113208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="53"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG03735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="327" mass="37200" checksum="A04A4381156BD28D" modified="2016-09-07" version="1">MNTLEQRRKENIKRNAILLQELELEHKHVKQQLQPARRPAKKRRKLDIPPPTRSSARIASASARPDYIGDGDTVTNSAPSSSRAKSSSAKAVAGKPSRVASPAPESHTLYPDLESLRAGWTAWEPVAPPPSRDSLGTYHFASHPDFTPNKSPADIIREGSFGGSYWRPLYSQRLGTTVSDDWRELPADWTAGLDADQYLTNPEYSAEINKHGVACGQSIEAWEAAGWIAHEYDVRGWFQWYCRFWMGRRCADDERQISRWKKCVGETGRWRRTLLKQYVTRGIRSVFDDGDDGVEGSDVSPVVSQTCLHWAYEVRQEALDRYWVERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C8F6</accession>
    <name>A0A177C8F6_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mid2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CC84DRAFT_1166826</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG03058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033423.1">
        <property type="nucleotide sequence ID" value="XM_018179060.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C8F6"/>
    <dbReference type="STRING" id="1460663.A0A177C8F6"/>
    <dbReference type="GeneID" id="28762546"/>
    <dbReference type="InParanoid" id="A0A177C8F6"/>
    <dbReference type="OrthoDB" id="4770059at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051694">
        <property type="entry name" value="Immunoregulatory_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549">
        <property type="entry name" value="PAIRED IMMUNOGLOBULIN-LIKE TYPE 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="212"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="163"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="164"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAG03058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="294" mass="31024" checksum="69F4309AA6A97459" modified="2016-09-07" version="1">MSFDNNMYYGWGAAGVVDSACYPLGTMKYDDIKPASSWELYYYSPAACPDDWARALTFTDGIPHNNMLTTLSVSASTTAILCCPSGFRYYTEGHVCTSAIKDGSTVKYVVPQNDDFGTLKIGPVSTSSYTAESHAFANGIVVMFQSSDVAMLKSAAVNPTAAVTSTSNLSTPTSTGHSETTGTASSTSAPTGAVTDAQSGTSSGGLSTGAKVGMGVGIPCALLLGLVFGWFLFRRRKANPYPPPGYDEAGMVKYAQVHEAHSEPPEIGGNHRMDIQPSDTKVAAAQVHQRHELQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C8T9</accession>
    <name>A0A177C8T9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pre-mRNA-splicing factor 18</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CC84DRAFT_1166270</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PRP18 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG04164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034529.1">
        <property type="nucleotide sequence ID" value="XM_018178916.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C8T9"/>
    <dbReference type="STRING" id="1460663.A0A177C8T9"/>
    <dbReference type="GeneID" id="28762402"/>
    <dbReference type="InParanoid" id="A0A177C8T9"/>
    <dbReference type="OrthoDB" id="10261918at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071021">
        <property type="term" value="C:U2-type post-spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000350">
        <property type="term" value="P:generation of catalytic spliceosome for second transesterification step"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.940.10:FF:000008">
        <property type="entry name" value="Related to potassium channel regulatory factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.940.10">
        <property type="entry name" value="Functional domain of the splicing factor Prp18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.110">
        <property type="entry name" value="Pre-mRNA processing factor 4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004098">
        <property type="entry name" value="Prp18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014906">
        <property type="entry name" value="PRP4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036285">
        <property type="entry name" value="PRP4-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039979">
        <property type="entry name" value="PRPF18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13007">
        <property type="entry name" value="PRE-MRNA SPLICING FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13007:SF19">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02840">
        <property type="entry name" value="Prp18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08799">
        <property type="entry name" value="PRP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47938">
        <property type="entry name" value="Functional domain of the splicing factor Prp18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158230">
        <property type="entry name" value="PRP4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Pre-mRNA processing factor 4 (PRP4)-like" evidence="10">
        <location>
            <begin position="131"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="Prp18" evidence="9">
        <location>
            <begin position="206"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="19"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="40"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OAG04164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="357" mass="41474" checksum="F8A4EC9031C8A2C7" modified="2016-09-07" version="1">MNLASLITKAKQKAPPAESSDKKFLKRSELEAQRQAAYRAEQEAAEKAREDRIARKRKAEEDDAAKEEERREKRRKFAEESRRKREQEAEEEERRRRKRLGLPDLPPKKEEGEEGTPVPEDEDIEEEELFAKLRALDEPAILFGETHKQRLKRYKKRVGADSLKAIMTNGPIPTTLQLVPEKDMLVSLTIPKDKDGREFLFRQLASYFTMVLEEWENTLARRTIEVKNSYPGKQAYNAMVQARENLRPLFKKMEQYDLPDSILEPVVEIVLAAQERRYVDANDGYLRLSIGKAAWPIGVTMVGIHERSAREKLHESDKNAAHIMSDEITRKYLQSIKRCLSFAQTRWPPTDQLQLMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C996</accession>
    <name>A0A177C996_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1095100</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG04223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034588.1">
        <property type="nucleotide sequence ID" value="XM_018174600.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C996"/>
    <dbReference type="STRING" id="1460663.A0A177C996"/>
    <dbReference type="GeneID" id="28758086"/>
    <dbReference type="InParanoid" id="A0A177C996"/>
    <dbReference type="OrthoDB" id="2257100at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07716">
        <property type="entry name" value="bZIP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="2">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="24"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG04223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="63" mass="7345" checksum="4D61BAC3D671977D" modified="2016-09-07" version="1" fragment="single">ARVEKRKANTMAARRYRQKRVDQMNTLESQLKDTQTERDALKVRCARLEGEVETLRALLAAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C9R4</accession>
    <name>A0A177C9R4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1217852</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG04393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034758.1">
        <property type="nucleotide sequence ID" value="XM_018182941.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C9R4"/>
    <dbReference type="STRING" id="1460663.A0A177C9R4"/>
    <dbReference type="GeneID" id="28766427"/>
    <dbReference type="InParanoid" id="A0A177C9R4"/>
    <dbReference type="OrthoDB" id="3357846at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG04393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="186" mass="20392" checksum="D5CA8705BB2CDB5C" modified="2016-09-07" version="1">MRPVHCIKVISWFSQNVQGKSLKDVADELGDAVDKLSCRRELEQVDVGADLEAERQSLHGTANGVGAVDNTEFPLQRQVNHLESALHQRTSDPEETDHGVILVDWYTQDDPKNLKNWPGLKKGFVGFILSFYTAAVYAAGLFYATSVGGGLLEHFNVSPVTAFLGLSLFILTYGIGDIVLALCLRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C9Y2</accession>
    <name>A0A177C9Y2_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA (cytosine-5-)-methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CC84DRAFT_1260700</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.37" evidence="1"/>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG03567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033932.1">
        <property type="nucleotide sequence ID" value="XM_018185002.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C9Y2"/>
    <dbReference type="STRING" id="1460663.A0A177C9Y2"/>
    <dbReference type="GeneID" id="28768488"/>
    <dbReference type="InParanoid" id="A0A177C9Y2"/>
    <dbReference type="OrthoDB" id="414133at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003886">
        <property type="term" value="F:DNA (cytosine-5-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044027">
        <property type="term" value="P:negative regulation of gene expression via chromosomal CpG island methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.120.10">
        <property type="entry name" value="DNA Methylase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050390">
        <property type="entry name" value="C5-Methyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001525">
        <property type="entry name" value="C5_MeTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10629">
        <property type="entry name" value="CYTOSINE-SPECIFIC METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10629:SF52">
        <property type="entry name" value="DNA (CYTOSINE-5)-METHYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00145">
        <property type="entry name" value="DNA_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00105">
        <property type="entry name" value="C5METTRFRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51679">
        <property type="entry name" value="SAM_MT_C5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 5 7" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="434"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="434"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAG03567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="537" mass="60954" checksum="06589093FBA051EC" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CAU4</accession>
    <name>A0A177CAU4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_1219195</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG03949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034314.1">
        <property type="nucleotide sequence ID" value="XM_018183062.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CAU4"/>
    <dbReference type="FunCoup" id="A0A177CAU4">
        <property type="interactions" value="129"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CAU4"/>
    <dbReference type="GeneID" id="28766548"/>
    <dbReference type="InParanoid" id="A0A177CAU4"/>
    <dbReference type="OrthoDB" id="1928087at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070210">
        <property type="term" value="C:Rpd3L-Expanded complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034967">
        <property type="term" value="C:Set3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46462">
        <property type="entry name" value="UPSET, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46462:SF3">
        <property type="entry name" value="UPSET, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SET" evidence="3">
        <location>
            <begin position="290"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="101"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="483"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="584"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="864"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="101"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="119"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="502"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="555"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="597"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="670"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="693"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="747"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="913"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="967"/>
            <end position="999"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAG03949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="999" mass="107970" checksum="B69377FD847DD764" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CAV2</accession>
    <name>A0A177CAV2_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GTP-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CC84DRAFT_1094698</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">GTPase involved in activation of the TORC1 signaling pathway, which promotes growth and represses autophagy in nutrient-rich conditions.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the GSE complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the GTR/RAG GTP-binding protein family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG04695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035060.1">
        <property type="nucleotide sequence ID" value="XM_018174577.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CAV2"/>
    <dbReference type="FunCoup" id="A0A177CAV2">
        <property type="interactions" value="250"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CAV2"/>
    <dbReference type="GeneID" id="28758063"/>
    <dbReference type="InParanoid" id="A0A177CAV2"/>
    <dbReference type="OrthoDB" id="10020193at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990131">
        <property type="term" value="C:Gtr1-Gtr2 GTPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010507">
        <property type="term" value="P:negative regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904262">
        <property type="term" value="P:negative regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd11384">
        <property type="entry name" value="RagA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000488">
        <property type="entry name" value="Small monomeric GTPase (Gtr1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006762">
        <property type="entry name" value="Gtr1_RagA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039397">
        <property type="entry name" value="RagA/B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11259">
        <property type="entry name" value="RAS-RELATED GTP BINDING RAG/GTR YEAST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11259:SF1">
        <property type="entry name" value="RAS-RELATED GTP-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04670">
        <property type="entry name" value="Gtr1_RagA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="326"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAG04695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="349" mass="39296" checksum="1000F10BAFD492DA" modified="2016-09-07" version="1">MNTTKRQKQRKVLLMGKSGAGKSSMRSIVFSNYVAKDVRRLGATIDVEHSNIKFMGNLMLNLWDCGGQDGFVENYLTHQRAHVFSSVAVLIFVFDIESREFAADVISYSSIIRALAEHSPSAAVFVLIHKMDLVQARLRQQLFDERTEYIRSASESFAPTVDFFATSIWDQSLYKAWTQIIYFLIPNARSIEGLLRELAEVVEARELILYERTTCLMVTHVTRDVEAENPFSDRFERISSILKTHKQSMAKHTGIPAGSANFAEMQIKTGRFMFFITRLTENTNLAAAIPPSEQIFNAARINIALARPRFAELDIASKPRPAVQQAFAHSADSGWEGRERESAAAGFEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CCT6</accession>
    <name>A0A177CCT6_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1092415</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG05455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035820.1">
        <property type="nucleotide sequence ID" value="XM_018174452.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CCT6"/>
    <dbReference type="STRING" id="1460663.A0A177CCT6"/>
    <dbReference type="GeneID" id="28757938"/>
    <dbReference type="InParanoid" id="A0A177CCT6"/>
    <dbReference type="OrthoDB" id="531564at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045271">
        <property type="term" value="C:respiratory chain complex I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044980">
        <property type="entry name" value="NDUFB2_plant/fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36987:SF1">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36987">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 2-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="22"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG05455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="58" mass="6771" checksum="F58DFA97C80D3FFB" modified="2016-09-07" version="1">MGPPKYPPMGNHPIHVHPVRPLYRFMSTALGASMWFFLMYRAKKDGPALLGWKHPWDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CCZ8</accession>
    <name>A0A177CCZ8_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Wax synthase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CC84DRAFT_1144926</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the wax synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG05513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035878.1">
        <property type="nucleotide sequence ID" value="XM_018176482.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CCZ8"/>
    <dbReference type="GeneID" id="28759968"/>
    <dbReference type="InParanoid" id="A0A177CCZ8"/>
    <dbReference type="OrthoDB" id="2796277at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008374">
        <property type="term" value="F:O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044851">
        <property type="entry name" value="Wax_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032805">
        <property type="entry name" value="Wax_synthase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31595">
        <property type="entry name" value="LONG-CHAIN-ALCOHOL O-FATTY-ACYLTRANSFERASE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31595:SF67">
        <property type="entry name" value="WAX SYNTHASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13813">
        <property type="entry name" value="MBOAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="34"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="63"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="249"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="287"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="319"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="Wax synthase" evidence="9">
        <location>
            <begin position="357"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="128"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="135"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAG05513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="537" mass="60829" checksum="326E2695BB2A37D2" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CD03</accession>
    <name>A0A177CD03_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_724801</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG05534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035899.1">
        <property type="nucleotide sequence ID" value="XM_018187190.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CD03"/>
    <dbReference type="GeneID" id="28770676"/>
    <dbReference type="InParanoid" id="A0A177CD03"/>
    <dbReference type="OrthoDB" id="3789983at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="Ricin B-like lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="282"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="191"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="282"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG05534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="395" mass="43551" checksum="4E656278535C7B81" modified="2016-09-07" version="1">MFDMISARYKLPQSRGASTSWAFGTLLAQTTLQNLARSFPASHIYKNLPLTSQGMVLARSPNGQPSGVVAQNRGDQDAPQKWLVESGDSPNIIALRCASTNDYLHANGGGNWSTVGTGAKQWWKLDTDNVTVPGACRLSPVEYPKVFLNHFQGIRVAKGQSMKVHMWQWEQPNQFCLTWYFFPADGSFGPSSGTSSAASEASTAKIEELETGKKEAEKKLKELQDNKTASDAKLKELQDSKKEYDAKLAELEEGKTGSADTIKELQDKLARRDRELEEHKAALKKNVDDQKAADAQRAHDDAAKQELKTHKKAAKLEDKARKKEAKQAEKAQKKPQKLELTSRLPPSPPPSPPQEKVTVSATSGVAEEVKNGCKHVVLPPPRKIRRKVVGIVYAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CDN4</accession>
    <name>A0A177CDN4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal lysine N-methyltransferase 4</fullName>
            <ecNumber evidence="6">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CC84DRAFT_1186695</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">S-adenosyl-L-methionine-dependent protein-lysine N-methyltransferase that monomethylates 60S ribosomal protein L42.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SETD6 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="6"/>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG05426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035791.1">
        <property type="nucleotide sequence ID" value="XM_018180875.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CDN4"/>
    <dbReference type="FunCoup" id="A0A177CDN4">
        <property type="interactions" value="278"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CDN4"/>
    <dbReference type="GeneID" id="28764361"/>
    <dbReference type="InParanoid" id="A0A177CDN4"/>
    <dbReference type="OrthoDB" id="341421at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19178">
        <property type="entry name" value="SET_SETD6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1410.10:FF:000007">
        <property type="entry name" value="Ribosomal lysine N-methyltransferase 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1420.10">
        <property type="entry name" value="Rubisco LSMT, substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1410.10">
        <property type="entry name" value="set domain protein methyltransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011383">
        <property type="entry name" value="N-lys_methylase_SETD6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015353">
        <property type="entry name" value="Rubisco_LSMT_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036464">
        <property type="entry name" value="Rubisco_LSMT_subst-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050600">
        <property type="entry name" value="SETD3_SETD6_MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044430">
        <property type="entry name" value="SETD6_SET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271:SF34">
        <property type="entry name" value="N-LYSINE METHYLTRANSFERASE SETD6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271">
        <property type="entry name" value="UNCHARACTERIZED PUTATIVE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09273">
        <property type="entry name" value="Rubis-subs-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF011771">
        <property type="entry name" value="RMS1_SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81822">
        <property type="entry name" value="RuBisCo LSMT C-terminal, substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SET" evidence="8">
        <location>
            <begin position="24"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="449"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR011771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAG05426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="473" mass="53297" checksum="AE0B99C809574DE9" modified="2016-09-07" version="1">MDSFDEASRVFLDWLKRSGAEISPKIELKDLRNHQAGRGVVATQNIAEDEVLFRIPRSAILSVENSILSSEIPKATFDALGPWLSLILAMLYEYFNSDASNWAPYFRVLPDEFNTLMFWSEDELAQLQASAVVHKIGRQSADENFKNELIPVIKEFAQLIFAGDERAQERAAEMESEAGMLLMHKMGSLIMAYAFDVEPAQSHKEIDEEGYASEDEDEALPKGMVPMADMLNADADRNNARLFYEEESLSMKALKPIQAGEEIFNDYGPLPRSDLLRRYGYITDNYSQYDVVEIPFDLVAQTASAANVYSEARLEYLDEQDLIETGYDVCASEPFTFQESVSPELVVVVETLLLDNDEFERLKRKGKLPKPEKVTAKGAEFLHRLVQVRLQQYATTLDEDLSTSNGASLSGEAMSKERRYTIARQVRIGEKKLLKQAEQALEQLGRDLVTANGSAKRPAEDEEAGQGKKQRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CED6</accession>
    <name>A0A177CED6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Zf-C2HC5-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1165571</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG05272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035637.1">
        <property type="nucleotide sequence ID" value="XM_018178747.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CED6"/>
    <dbReference type="FunCoup" id="A0A177CED6">
        <property type="interactions" value="113"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CED6"/>
    <dbReference type="GeneID" id="28762233"/>
    <dbReference type="InParanoid" id="A0A177CED6"/>
    <dbReference type="OrthoDB" id="338816at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0180022">
        <property type="term" value="C:RQC-trigger complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072344">
        <property type="term" value="P:rescue of stalled ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039128">
        <property type="entry name" value="TRIP4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009349">
        <property type="entry name" value="TRIP4/RQT4_C2HC5_Znf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12963:SF4">
        <property type="entry name" value="ACTIVATING SIGNAL COINTEGRATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12963">
        <property type="entry name" value="THYROID RECEPTOR INTERACTING PROTEIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06221">
        <property type="entry name" value="zf-C2HC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TRIP4/RQT4 C2HC5-type zinc finger" evidence="2">
        <location>
            <begin position="238"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="300"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="434"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="489"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="323"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="489"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG05272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="537" mass="58660" checksum="14E9F39FC782D6B6" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CEL1</accession>
    <name>A0A177CEL1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_832303</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG05207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035572.1">
        <property type="nucleotide sequence ID" value="XM_018187571.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CEL1"/>
    <dbReference type="GeneID" id="28771057"/>
    <dbReference type="InParanoid" id="A0A177CEL1"/>
    <dbReference type="OrthoDB" id="10616407at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG05207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="268" mass="29986" checksum="19083F6636FE7AB3" modified="2016-09-07" version="1">MALCVRYNRSAVDPWIGAPLRIDLSISLCRRPAPSFHHAIQPQVHHHPRAQEAPSPCSKNGWIVHPPRFPRGYHTHTAKHLHSHRSYASHPSTPKARSIPQPGRGRRRWSICRHPAANRPCTTRSKQFSGAALSASQTASRFLPLRLLCRPHMTALPACTYTTYTYMHMSIAAQRSSCDEVEHHSPSNLLTCKLLQGVVIAIAVPVVLGRFLKERLDRSRLRCVGRPPLSVELGVLSLQPLLYALQRGFPAKTHDGEWPGGRYGDLDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CEL3</accession>
    <name>A0A177CEL3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Gfd2/YDR514C-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1205681</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG06074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036439.1">
        <property type="nucleotide sequence ID" value="XM_018181993.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CEL3"/>
    <dbReference type="STRING" id="1460663.A0A177CEL3"/>
    <dbReference type="GeneID" id="28765479"/>
    <dbReference type="InParanoid" id="A0A177CEL3"/>
    <dbReference type="OrthoDB" id="5953249at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040151">
        <property type="entry name" value="Gfd2/YDR514C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048519">
        <property type="entry name" value="Gfd2/YDR514C-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28083">
        <property type="entry name" value="GOOD FOR FULL DBP5 ACTIVITY PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28083:SF1">
        <property type="entry name" value="GOOD FOR FULL DBP5 ACTIVITY PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21762">
        <property type="entry name" value="DEDDh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfd2/YDR514C-like C-terminal" evidence="1">
        <location>
            <begin position="51"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF21762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG06074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="360" mass="40748" checksum="800323ADF416A4D0" modified="2016-09-07" version="1">MSTNNTTAFPETINGVRAFFNSIPSQTDKLRYVLGRLTKPIAPRLAEATVVNCVDTEHYEWDHSKLTEIGLNVFASGDLRQYANTLEANAENMLKEIYFYHFRMLPNAHCINEKFCPGNPEANRFGNTRFATYAEGKAMLTECFNWDINQGRPQDGKCPSILIGHALHNDTGGLEETIGFDPYASGTVVATLDTQQMAREMGIYNPAGSRHEIGLRDLCYHFKIPYRDSHTASNDAAYTIISAIYMALYGRDMPKTGKTVLHSIEAVEATSRMYSNARFGISRYCTRCHRTNHFKKDCHARIPPCHKCQARRTPGRDGTLPDVHWFTKGRRAHLPEDCTWGSSIKVLHGLTRRTDWRDTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CEN7</accession>
    <name>A0A177CEN7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA-directed RNA polymerase II subunit RPB3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CC84DRAFT_1093290</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG05200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035565.1">
        <property type="nucleotide sequence ID" value="XM_018174504.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CEN7"/>
    <dbReference type="FunCoup" id="A0A177CEN7">
        <property type="interactions" value="973"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CEN7"/>
    <dbReference type="GeneID" id="28757990"/>
    <dbReference type="InParanoid" id="A0A177CEN7"/>
    <dbReference type="OrthoDB" id="270173at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07031">
        <property type="entry name" value="RNAP_II_RPB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.120.12:FF:000002">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.120.12">
        <property type="entry name" value="DNA-directed RNA polymerase, insert domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.10">
        <property type="entry name" value="RNA polymerase, RBP11-like subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00320">
        <property type="entry name" value="RNApol_arch_Rpo3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001514">
        <property type="entry name" value="DNA-dir_RNA_pol_30-40kDasu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011262">
        <property type="entry name" value="DNA-dir_RNA_pol_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011263">
        <property type="entry name" value="DNA-dir_RNA_pol_RpoA/D/Rpb3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036603">
        <property type="entry name" value="RBP11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022842">
        <property type="entry name" value="RNAP_Rpo3/Rpb3/RPAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036643">
        <property type="entry name" value="RNApol_insert_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050518">
        <property type="entry name" value="Rpo3/RPB3_RNA_Pol_subunit"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001988">
        <property type="entry name" value="PRK00783.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11800">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11800:SF2">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01000">
        <property type="entry name" value="RNA_pol_A_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01193">
        <property type="entry name" value="RNA_pol_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00662">
        <property type="entry name" value="RPOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56553">
        <property type="entry name" value="Insert subdomain of RNA polymerase alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55257">
        <property type="entry name" value="RBP11-like subunits of RNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00446">
        <property type="entry name" value="RNA_POL_D_30KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="DNA-directed RNA polymerase RpoA/D/Rpb3-type" evidence="9">
        <location>
            <begin position="6"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="186"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="186"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00072506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAG05200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="316" mass="34328" checksum="D1D332724B49345D" modified="2016-09-07" version="1" fragment="single">QANDKRAYFIVRDWNLETANSLRRVMLAEVPTLAIDTVEVLDNTSVLADEFIAHRLGLIPLIAEDVDKLVDFRDCDCEDSRCDNCSVTLRLKAKCTGNDVMKVYARDLVIESMPPSDRLGQPVITDAEGNGSCIVKLRKGQAIDMRCIAKKGIAKEHAKWAPSAAIGFEYDPANKLHHLDLWYEDDDPKKEPVDETRVDLDGGPEKTDEPFNYDAVPERFFFDVETVGGLSPDSIVNNGIKVLQQKLASVIKELTGVDEANAGLEGAQSPTMEGGFGNDGYGNDNGYTTPGYGGGNAYPGGTTPYGATPYGGASGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CEZ6</accession>
    <name>A0A177CEZ6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Polysaccharide synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CC84DRAFT_1205759</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG06185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036550.1">
        <property type="nucleotide sequence ID" value="XM_018181996.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CEZ6"/>
    <dbReference type="STRING" id="1460663.A0A177CEZ6"/>
    <dbReference type="GeneID" id="28765482"/>
    <dbReference type="InParanoid" id="A0A177CEZ6"/>
    <dbReference type="OrthoDB" id="2849215at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052427">
        <property type="entry name" value="Glycosyltrans_GT2/GT47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47844:SF1">
        <property type="entry name" value="EXOSTOSIN-LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47844">
        <property type="entry name" value="SYNTHASE CPS1, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G02500)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13641">
        <property type="entry name" value="Glyco_tranf_2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="336"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAG06185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="408" mass="46680" checksum="31C1F74031F14E46" modified="2016-09-07" version="1">MDIALGFLWAWDVYHKVLTSYLAKKYRTVPLPDTPSYHCNEVSIIVPTIETEATFTECVRLWLRSNPREIIIVTVPRYKAHVEQLVQPVKDLTDKITILVAPVANKRQQIMMGARKATGKIIALVDDDAYWRGSGVMPYMLAAFEDSSVGGVAGLQSPEIPLERQDASVITVWEAAAALDMFKMNHDQPVRFTADGGLWVLSGRTVFIRAAILKDPHFAEAYTHQVIDGKIVNGADDVWVTEWILDHGWKICVQNAPEAEIFTNVPHDRKFLLQNLRWERGNFRSFWERIFGNPGYRTMKQRHPHLTSVMIEKLTRPVWVSAYIVAWSTTLQTAPWLAATFLLWMTLGMGGSFWTYRAFVKEYPYMAGKVWKLMLMGNMGPVMDIYAFITMKDDRWLTRVADAQYVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CFC2</accession>
    <name>A0A177CFC2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_1187241</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG06295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036660.1">
        <property type="nucleotide sequence ID" value="XM_018180915.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CFC2"/>
    <dbReference type="GeneID" id="28764401"/>
    <dbReference type="InParanoid" id="A0A177CFC2"/>
    <dbReference type="OrthoDB" id="2250022at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000057">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF6">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G16690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="17"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="113"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="147"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="181"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="254"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="285"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="317"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="341"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="376"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="408"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="20"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAG06295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="475" mass="52767" checksum="A4934D10B5FE8F59" modified="2016-09-07" version="1">MDPERRKQVEKRLKMKLDLRCSIFVLMYIMNYLDRNNLGAARLKGLEADLRLDETQYATCLSILYVGYILMQIPSNMIINKVPRPSWYIGIVMLIWGMISTLSGNVTSFGGMVAIRFCIGFVEAAFLPGALLILSKWYTRRELTKRNAILFCGNLISNAFSSLVGAGVLSNMEGTLGHRAWRWLFWIEGAATMFIAILAIFILPDLPHNTRGFTEEEGAVAVLRMTEDVGEADVDSETMGAFSGLLMAVKDVKIYVMMLTFTAYVVGLSFNAFFPTLTGTLGFGYVPTLLMSAPPWAFACIVSLINAWHADRCEERFWHIVGPIIGGIVGFVISMSTENVAARYVALFLQASAYAGFIVFYSWISSSFPRPPAKRAVAIAMINAFSQLGNIAGSYVWNMKANGYRKSYGLVTAMFGVTIFGCWVFKIILQRLNKQIDEGEAAWVTSGDVAEQTAKTEGVSVEEGTKLVRGFRYLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CFC8</accession>
    <name>A0A177CFC8_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 16 17">Phosphatidate cytidylyltransferase</fullName>
            <ecNumber evidence="6 16 17">2.7.7.41</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CC84DRAFT_1196238</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 16 17">
            <text>a 1,2-diacyl-sn-glycero-3-phosphate + CTP + H(+) = a CDP-1,2-diacyl-sn-glycerol + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:16229"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="EC" id="2.7.7.41"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 16 17">Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 3/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 16 17">Belongs to the CDS family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.41" evidence="6 16 17"/>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG06036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036401.1">
        <property type="nucleotide sequence ID" value="XM_018181446.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CFC8"/>
    <dbReference type="FunCoup" id="A0A177CFC8">
        <property type="interactions" value="730"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CFC8"/>
    <dbReference type="GeneID" id="28764932"/>
    <dbReference type="InParanoid" id="A0A177CFC8"/>
    <dbReference type="OrthoDB" id="10260889at2759"/>
    <dbReference type="UniPathway" id="UPA00557">
        <property type="reaction ID" value="UER00614"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004605">
        <property type="term" value="F:phosphatidate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016024">
        <property type="term" value="P:CDP-diacylglycerol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000374">
        <property type="entry name" value="PC_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016720">
        <property type="entry name" value="PC_Trfase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13773">
        <property type="entry name" value="PHOSPHATIDATE CYTIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13773:SF8">
        <property type="entry name" value="PHOSPHATIDATE CYTIDYLYLTRANSFERASE, PHOTORECEPTOR-SPECIFIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01148">
        <property type="entry name" value="CTP_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018269">
        <property type="entry name" value="PC_trans_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01315">
        <property type="entry name" value="CDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 16" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="12 16" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 16 17" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="14 16" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="15 16" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 16 17" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 16 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="96"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="170"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="199"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="223"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="265"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="338"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRNR" id="PIRNR018269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU003938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="OAG06036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="458" mass="51848" checksum="3F15A722D35C90E4" modified="2016-09-07" version="1">MAKPRKDVKFQHRGSNPSTKARRPSMSVSEHSETAHSEPSSPTRNGHAAAKIDEAPEPPAQTEYEKKMQNFYTRTVWTFAMLGGFFWALFAGHIYIIILITALQIISFKEVIAIHSVPSKARNLRFTKSLNWYFLGTTMYFLYGESVIYYFKHILLVDRILLPLATHHRFISFMLYIIGFIFFVSSLQKGHYKFQFSQFAWTHMALFLIVGQAHFIINNVFEGFIWFFMPVALVVTNDIFAYLCGITFGRTPLIKISPKKTWEGFLGAWFFTVLLGILMTHLMARSKYFICPVNDLGANLFTGLECTVNPVFTPKTYVVPFIPPGLPAISNTYVFKPLYLHILVLATFASLIAPFGGFFASGLKRTFKIKDFGDSIPGHGGVTDRMDCQFIMGTITFFYYSSFIAVNHASVGSVLEAAITGLTPEEQVEVVRILGRSLVEKDMLPTQILQYLTAPAKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CFT7</accession>
    <name>A0A177CFT7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_1146640</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG06474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036839.1">
        <property type="nucleotide sequence ID" value="XM_018176561.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CFT7"/>
    <dbReference type="GeneID" id="28760047"/>
    <dbReference type="InParanoid" id="A0A177CFT7"/>
    <dbReference type="OrthoDB" id="2985014at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000722">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF51">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="46"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="90"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="141"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="179"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="212"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="282"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="320"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="347"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="375"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="406"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="440"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAG06474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="484" mass="53646" checksum="D7529D702915D8B5" modified="2016-09-07" version="1">MANSPELSKELPPSERAISPVPSDIERQNEDDALLKAAHRKVDKRLLLWYAFVYLIMRIHVSNISNSAIINLESGDGIRRQLGNLSSQQWGWALSIFYYPYMFLEPLATLALKKFNPNVWMSRIMLTWGIISMCQGATQDYAGILACRFFLGAAEAGFYPGVLYHLSFWYRTERLPLRIGFFYACGMFSGTISGLLAYAISFMNGAGGLAGWRWLFILEGMPAIFCSVVTYFFLPNYPETVVFLDETERQAVLDDLPKQAPSMQAKTFSRAQTVSLFKDPTFIPFLMIWITHGIGGWGISFVLPTVIYELGISNTAISQVMTMPPFTLVFVILCTLAYLIHTSRLSPWIAGLAVELTQIICYILLITVKNAVAKYIFVMIATAASQSFFALMWPERIRAAKGTTTAGLAIGITNASCQLMGIVGPQIYQPKFGPTYRVSYICSIGLLSACLAAVGTSWFFVRRGDEGVGGEEETTASPSTGRAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CGB5</accession>
    <name>A0A177CGB5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ketohexokinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_1142575</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG06635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037000.1">
        <property type="nucleotide sequence ID" value="XM_018176373.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CGB5"/>
    <dbReference type="STRING" id="1460663.A0A177CGB5"/>
    <dbReference type="GeneID" id="28759859"/>
    <dbReference type="InParanoid" id="A0A177CGB5"/>
    <dbReference type="OrthoDB" id="204058at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002173">
        <property type="entry name" value="Carboh/pur_kinase_PfkB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052562">
        <property type="entry name" value="Ketohexokinase-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42774:SF3">
        <property type="entry name" value="KETOHEXOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42774">
        <property type="entry name" value="PHOSPHOTRANSFERASE SYSTEM TRANSPORT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00584">
        <property type="entry name" value="PFKB_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carbohydrate kinase PfkB" evidence="3">
        <location>
            <begin position="5"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAG06635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="329" mass="36543" checksum="826AF9AAD933C61F" modified="2016-09-07" version="1">MAIGIVCIGAVYIDTILSVPKFPNEDEKLRATSHTRRRGGNCTNTLEVLSQLVEQSEQTFEEARAHLYLLSVLPARQSTDVQFISQSIPDTNIDSGCIFREGFENAASSYIIRSAANNSRTIVSHNSLPEMTTQEFIDGASAIRGQSKVEQHWFHFEGRIPVVTEASVRWLSGNFPTAKISVECEKPERDYMVHVSREADVAFFSRIWAEANSYNDPRTFLGDQIEYMKPGAILVCTWGAAGATCVYNKTGRREDSEWANTTAWKPTTESVEVVDTIGAGDTFIAGFLYALNCQGQWTLQRKLEFANELAGRKVLQSGFGGLAERMSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CGS7</accession>
    <name>A0A177CGS7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Spindle pole body component</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CC84DRAFT_1119689</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
            <location evidence="5">Cytoskeleton</location>
            <location evidence="5">Microtubule organizing center</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the TUBGCP family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG06049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036414.1">
        <property type="nucleotide sequence ID" value="XM_018175560.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CGS7"/>
    <dbReference type="STRING" id="1460663.A0A177CGS7"/>
    <dbReference type="GeneID" id="28759046"/>
    <dbReference type="InParanoid" id="A0A177CGS7"/>
    <dbReference type="OrthoDB" id="775571at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000930">
        <property type="term" value="C:gamma-tubulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043015">
        <property type="term" value="F:gamma-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051011">
        <property type="term" value="F:microtubule minus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051225">
        <property type="term" value="P:spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1900:FF:000013">
        <property type="entry name" value="Spindle pole body component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1900">
        <property type="entry name" value="Gamma-tubulin complex, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007259">
        <property type="entry name" value="GCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045818">
        <property type="entry name" value="GCP6_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040457">
        <property type="entry name" value="GCP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042241">
        <property type="entry name" value="GCP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041470">
        <property type="entry name" value="GCP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302">
        <property type="entry name" value="GAMMA TUBULIN COMPLEX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302:SF70">
        <property type="entry name" value="GAMMA-TUBULIN COMPLEX COMPONENT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19340">
        <property type="entry name" value="GCP6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04130">
        <property type="entry name" value="GCP_C_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17681">
        <property type="entry name" value="GCP_N_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3 5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma-tubulin complex component 6 N-terminal" evidence="8">
        <location>
            <begin position="44"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="Gamma tubulin complex component protein N-terminal" evidence="7">
        <location>
            <begin position="166"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="Gamma tubulin complex component C-terminal" evidence="6">
        <location>
            <begin position="563"/>
            <end position="911"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF19340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAG06049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="912" mass="102942" checksum="4B94165670E01F6E" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CH26</accession>
    <name>A0A177CH26_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CC84DRAFT_1120565</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the aldo/keto reductase family. Aldo/keto reductase 2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG06531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036896.1">
        <property type="nucleotide sequence ID" value="XM_018175579.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CH26"/>
    <dbReference type="FunCoup" id="A0A177CH26">
        <property type="interactions" value="62"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CH26"/>
    <dbReference type="GeneID" id="28759065"/>
    <dbReference type="InParanoid" id="A0A177CH26"/>
    <dbReference type="OrthoDB" id="48988at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050523">
        <property type="entry name" value="AKR_Detox_Biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364">
        <property type="entry name" value="NADH-SPECIFIC METHYLGLYOXAL REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364:SF7">
        <property type="entry name" value="NADP-DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="4">
        <location>
            <begin position="29"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAG06531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="402" mass="44355" checksum="8D42A126650A8EA9" modified="2016-09-07" version="1">MAFPAPPKPTSVLGRHRILSPTAGARVSPLCLGAMNFGDAWKSALGECTKDTAFAMLDYFYSQGGNFIDTAVNYQFGESEQWLGEWMEARGRRDEMVIATKFTGGQYPHLGDKVIQSNFSGNGSKNIHTSVKRSLKNLRTDYIDLYYVHLYDHTTSVPELMHTLNTLVSQRLVLYLGISDTPAWLVVKCNDYARQHGLRPFSVYQGRWGAGCRDLEREVIPMCLSEGMAIAPWGVLGGGSFKKAEDKEKEGTRALPVGSKSRDEQVRSVLEKVAEKKGTGATSVALAYVLHKAPYVFPIIGGRKVDYLSQNIEALKLQLDAEDMATIDAAYGFEIGFPHDFLSGGNNMVLGPEHNAFNGRGGYFDYPEGVKPTRPHEGPLDRQVASLPFAQAKAKKEGEENF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CHE0</accession>
    <name>A0A177CHE0_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1164485</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG06147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036512.1">
        <property type="nucleotide sequence ID" value="XM_018178495.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CHE0"/>
    <dbReference type="GeneID" id="28761981"/>
    <dbReference type="InParanoid" id="A0A177CHE0"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008058204" description="Secreted protein" evidence="1">
        <location>
            <begin position="30"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG06147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="71" mass="7642" checksum="88CDCAC3DBF8C2E8" modified="2016-09-07" version="1">MLLRSTNSLGGWGVLSIAIFGLSLDQATSTSLATLFLDTTETVQWVPFAGVQGRREDPTNCAVLQAIITWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CHS6</accession>
    <name>A0A177CHS6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_763764</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG06409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036774.1">
        <property type="nucleotide sequence ID" value="XM_018187349.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CHS6"/>
    <dbReference type="GeneID" id="28770835"/>
    <dbReference type="InParanoid" id="A0A177CHS6"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG06409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="89" mass="9405" checksum="B0014A3D5DA2FF31" modified="2016-09-07" version="1">MFQRVCLLAAGQSACAPPQCAAAAAAAAARHRRALRSALRFLSSAGVPLESSFDRQADVIRGPGDAHLFSDTCRSRTAGSKRRCAVHHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CI59</accession>
    <name>A0A177CI59_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Mannosyltransferase</fullName>
            <ecNumber evidence="12">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CC84DRAFT_1242458</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the third mannose to Man2-GlcN-acyl-PI during GPI precursor assembly.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Endoplasmic reticulum membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase 22 family. PIGB subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="12"/>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG07193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037558.1">
        <property type="nucleotide sequence ID" value="XM_018184084.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CI59"/>
    <dbReference type="FunCoup" id="A0A177CI59">
        <property type="interactions" value="858"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CI59"/>
    <dbReference type="GeneID" id="28767570"/>
    <dbReference type="InParanoid" id="A0A177CI59"/>
    <dbReference type="OrthoDB" id="416834at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000026">
        <property type="term" value="F:alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005599">
        <property type="entry name" value="GPI_mannosylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22760">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22760:SF4">
        <property type="entry name" value="GPI MANNOSYLTRANSFERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03901">
        <property type="entry name" value="Glyco_transf_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="223"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="259"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="291"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="320"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="358"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="413"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OAG07193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="613" mass="69123" checksum="0F1368CA9D8EEFDD" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CIY4</accession>
    <name>A0A177CIY4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_1163067</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG06747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037112.1">
        <property type="nucleotide sequence ID" value="XM_018178166.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CIY4"/>
    <dbReference type="STRING" id="1460663.A0A177CIY4"/>
    <dbReference type="GeneID" id="28761652"/>
    <dbReference type="InParanoid" id="A0A177CIY4"/>
    <dbReference type="OrthoDB" id="1669814at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050664">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000245">
        <property type="entry name" value="Short chain dehydrogenase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008">
        <property type="entry name" value="BENZIL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008:SF4">
        <property type="entry name" value="CHAIN DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G08710)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAG06747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="265" mass="28630" checksum="1795A1568ECC979B" modified="2016-09-07" version="1">MSTKSLPEFSLSGKVILVSGAARGLGLTQAEALLEAGATVYALDRLPEPSPDFEPIAARAEKEFGTQLHYRQIDVREVEQLNKIVEDIASKHGRLDGLIAAAGIQQETSALEYTAADANRMFEVNITGVFMTSQAVAKQMIKYGNGGSIVMIASMSGSVANKGLICPAYNASKAGVIQLARNLAMEWGQYNIRVNTISPGYIVTAMVEALFVKYPERKESWPKDNMLGRLSKPKEYRGAAVFLLSDASSFMTGSDLKMDGGHSAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CIY9</accession>
    <name>A0A177CIY9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glutamyl-tRNA amidotransferase complex subunit Gta3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_631255</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG06942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037307.1">
        <property type="nucleotide sequence ID" value="XM_018186949.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CIY9"/>
    <dbReference type="FunCoup" id="A0A177CIY9">
        <property type="interactions" value="77"/>
    </dbReference>
    <dbReference type="GeneID" id="28770435"/>
    <dbReference type="InParanoid" id="A0A177CIY9"/>
    <dbReference type="OrthoDB" id="5522061at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030956">
        <property type="term" value="C:glutamyl-tRNA(Gln) amidotransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070681">
        <property type="term" value="P:glutaminyl-tRNAGln biosynthesis via transamidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006450">
        <property type="term" value="P:regulation of translational fidelity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036113">
        <property type="entry name" value="Asp/Glu-ADT_sf_sub_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003837">
        <property type="entry name" value="GatC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049545">
        <property type="entry name" value="Gta3_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15004">
        <property type="entry name" value="GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE SUBUNIT C, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15004:SF0">
        <property type="entry name" value="GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE SUBUNIT C, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20978">
        <property type="entry name" value="Gta3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141000">
        <property type="entry name" value="Glu-tRNAGln amidotransferase C subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamyl-tRNA amidotransferase complex subunit Gta3" evidence="1">
        <location>
            <begin position="76"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG06942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="207" mass="22827" checksum="1485C1F9A3559E41" modified="2016-09-07" version="1">MILRRALLFSRSIPRHVPRPVVPLRTISGIAQAPNANDSLPSASASMGFEDIQIALESDPTWSVESLLPPANKAPNAPEISSQQLHHLLRLSALPLPNSQEDEEKMLSTLADQLHFVGKIQQVDTTGVKPLRAIRNETAAAEVEQTVTLETLKDALAKEKVIGKHYKRIQRATTPVDASDVESWDVLGSAERKQGKYFVVESERPQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CIZ7</accession>
    <name>A0A177CIZ7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">MFS monocarboxylate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_650232</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG07286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037651.1">
        <property type="nucleotide sequence ID" value="XM_018187005.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CIZ7"/>
    <dbReference type="GeneID" id="28770491"/>
    <dbReference type="InParanoid" id="A0A177CIZ7"/>
    <dbReference type="OrthoDB" id="2213137at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF287">
        <property type="entry name" value="MFS MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="106"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="163"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="196"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="236"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="278"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="306"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="331"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="366"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="407"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAG07286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="434" mass="47073" checksum="9B2152EB74C613A2" modified="2016-09-07" version="1">MDDHELQAINPREVEVDSDPNEQNLPRVDGGKDAYLVLASVFVQGALIWGFVYGFGVFQEYYSRQPQFAGNVSGLAAIGTTGSGIMYLTSPLVYGFFQCYPEWRRTVSLIGFAIMLSGMVGASFANSVAQLLVTQGVLYGLGGSLLFFPVYSYLDDWFVKRRGLAFGVMIAGDGTGGVVIPLITQWMLDRWGFRTAMRAWSIISFLFVSASLIYLKPHPNARNTAAPVSRGFDMRFLRSSAFWILQAGNICQGLGYFMPILYMPSFAAARGWSSITGTIAVSLCNISIVVGATATGWIVDRYHVTTAIMISCVGTMMAVFIFWSFSIYQPMLFIFAITYGVFAGGFPATWSGCANPVRRKYPVENGMIVALFTAGKGIASVISGPVSGALVEADTWKGQVGFAYGSGYGYMIIFSGITASFASIGWIGKRLGVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2023-09-13" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CJR6</accession>
    <name>A0A177CJR6_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1163635</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG07491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037856.1">
        <property type="nucleotide sequence ID" value="XM_018178311.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CJR6"/>
    <dbReference type="GeneID" id="28761797"/>
    <dbReference type="InParanoid" id="A0A177CJR6"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008058288" description="Secreted protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG07491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="91" mass="10074" checksum="4B170AF4D25F47D2" modified="2016-09-07" version="1">MVFPKRLFFGSGFPLLVSAFCCHVVFVASTCRKTSPHSKHGQNTYSTRRSYGMWVSLLRATADLMESLPRVHFACSTVSSLATAHSAVRPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CJZ3</accession>
    <name>A0A177CJZ3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_520637</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG07813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038178.1">
        <property type="nucleotide sequence ID" value="XM_018186603.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CJZ3"/>
    <dbReference type="STRING" id="1460663.A0A177CJZ3"/>
    <dbReference type="GeneID" id="28770089"/>
    <dbReference type="InParanoid" id="A0A177CJZ3"/>
    <dbReference type="OrthoDB" id="3944494at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022698">
        <property type="entry name" value="OrsD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12013">
        <property type="entry name" value="OrsD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG07813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="149" mass="16897" checksum="E85B72EB63789A61" modified="2016-09-07" version="1">MDLFICYPEYHVLVCRSCAYAVAPPHLAAHMATKHANDICSKDNLHRTTKVAATLATRLREEYDLLDPTTSIIPRPPPTKPPFPNLKPYPRAAIPGRHRHPALGVDRTASAHSQPYGSRRTVRQIARKQGNYQWEPTLLSHICCQNRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CKC1</accession>
    <name>A0A177CKC1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein kish</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CC84DRAFT_1163529</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Involved in the early part of the secretory pathway.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Golgi apparatus membrane</location>
            <topology evidence="2 9">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the KISH family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG07318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037683.1">
        <property type="nucleotide sequence ID" value="XM_018178284.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CKC1"/>
    <dbReference type="FunCoup" id="A0A177CKC1">
        <property type="interactions" value="193"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CKC1"/>
    <dbReference type="GeneID" id="28761770"/>
    <dbReference type="InParanoid" id="A0A177CKC1"/>
    <dbReference type="OrthoDB" id="10034655at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051523">
        <property type="entry name" value="KISH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009653">
        <property type="entry name" value="Ksh1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13229">
        <property type="entry name" value="PROTEIN KISH-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06842">
        <property type="entry name" value="DUF1242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0732">Signal</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007948974" description="Protein kish" evidence="9">
        <location>
            <begin position="25"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="54"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU910717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAG07318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="72" mass="8418" checksum="35F3767C3137E806" modified="2016-09-07" version="1">MTALFNFQSLILVILLTICTSTYAHYYFPAFIDRNKNNYFMGVFWKCARVGERMSPYIALGLVVMAMMEFWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CKE5</accession>
    <name>A0A177CKE5_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein-lysine N-methyltransferase EFM6</fullName>
            <ecNumber evidence="1">2.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Elongation factor methyltransferase 6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">EFM6</name>
        <name evidence="2" type="ORF">CC84DRAFT_1143688</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">S-adenosyl-L-methionine-dependent protein-lysine N-methyltransferase that methylates elongation factor 1-alpha.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class I-like SAM-binding methyltransferase superfamily. METTL21 family. EFM6 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="1"/>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG07267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037632.1">
        <property type="nucleotide sequence ID" value="XM_018176426.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CKE5"/>
    <dbReference type="FunCoup" id="A0A177CKE5">
        <property type="interactions" value="400"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CKE5"/>
    <dbReference type="GeneID" id="28759912"/>
    <dbReference type="InParanoid" id="A0A177CKE5"/>
    <dbReference type="OrthoDB" id="407325at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03198">
        <property type="entry name" value="Methyltr_EFM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033684">
        <property type="entry name" value="EFM6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF152">
        <property type="entry name" value="PROTEIN-LYSINE N-METHYLTRANSFERASE EFM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="82"/>
            <end position="84"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG07267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="228" mass="25340" checksum="88436F55D72AA4F1" modified="2016-09-07" version="1">MSDSEENSVFGVSEDLVPPALIKSAGVSEVDFDGLLSPPLKLQEDLKNGCGGQLWPAGMVLSKYMLRKHKSDLNGKEIIELGAGGGLVGLAVALGCGTDTILHITDQEPMFELMKQNIVLNNLTSKVSAKIYDWGQPTPSGLPKYPDIILAADCVYFEPAFPLLQETLKDLIGEKTVCYFCFKKRRRADLQFMKVARKMFDVKEVEDDPDKKIYSRQSLFLYRVTKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CKW3</accession>
    <name>A0A177CKW3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Dystroglycan-type cadherin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CC84DRAFT_657975</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG07490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037855.1">
        <property type="nucleotide sequence ID" value="XM_018187049.1"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CKW3"/>
    <dbReference type="GeneID" id="28770535"/>
    <dbReference type="InParanoid" id="A0A177CKW3"/>
    <dbReference type="OrthoDB" id="41532at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006644">
        <property type="entry name" value="Cadg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031305">
        <property type="entry name" value="Casein_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05345">
        <property type="entry name" value="He_PIG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00736">
        <property type="entry name" value="CADG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00306">
        <property type="entry name" value="CASEIN_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011977766" description="Dystroglycan-type cadherin-like domain-containing protein" evidence="4">
        <location>
            <begin position="16"/>
            <end position="1295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="447"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="domain" description="Dystroglycan-type cadherin-like" evidence="5">
        <location>
            <begin position="134"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="Dystroglycan-type cadherin-like" evidence="5">
        <location>
            <begin position="321"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="411"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="477"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="596"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="753"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="883"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="925"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="988"/>
            <end position="1146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="413"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="602"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="614"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="632"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="804"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="849"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="925"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1000"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1024"/>
            <end position="1034"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1035"/>
            <end position="1051"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1065"/>
            <end position="1076"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1104"/>
            <end position="1117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAG07490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="1295" mass="141134" checksum="FF55D38CF272BCE0" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CLL3</accession>
    <name>A0A177CLL3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Permease of the major facilitator superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CC84DRAFT_1085784</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038496.1">
        <property type="nucleotide sequence ID" value="XM_018174116.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CLL3"/>
    <dbReference type="GeneID" id="28757602"/>
    <dbReference type="InParanoid" id="A0A177CLL3"/>
    <dbReference type="OrthoDB" id="2250022at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000057">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF78">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01370)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="48"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="118"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="150"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="180"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="215"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="288"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="319"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="350"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="376"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="409"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="440"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="52"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="463"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAG08131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="513" mass="57589" checksum="BCEC51DCCDD3D6B7" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CM01</accession>
    <name>A0A177CM01_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_1185402</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038949.1">
        <property type="nucleotide sequence ID" value="XM_018180802.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CM01"/>
    <dbReference type="STRING" id="1460663.A0A177CM01"/>
    <dbReference type="GeneID" id="28764288"/>
    <dbReference type="InParanoid" id="A0A177CM01"/>
    <dbReference type="OrthoDB" id="4161332at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051615">
        <property type="entry name" value="Transcr_Regulatory_Elem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313:SF85">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="7">
        <location>
            <begin position="72"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAG08584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="420" mass="47302" checksum="4812DCE8EF8FCC38" modified="2016-09-07" version="1">MATSGRYYSEFLLTVMCAHAARYEEGNYANILLSRVRHLLGTAIQQPSSIPTVQALLQLSARELAHGSMSQAWNYSGIAFRMASDLGLEYIGPNVRGLGPVDLEIRKRLFWSCYFWDKTLALIDDAMELEEWSPYHGDSLDLTRLAQNQYPDRKSHAVSCFANSCKLSIIINDIILQLYSRKSRTITEAALRNIKMRLDLWRVESPAHLRYDPDNLPSVCPPPHIISQNMLYYTTMILAYRPFWSVSTHYQVCILAAEGIEKLVLLLESTFGLENITYLMGYCIYTGASAILEDAKSSGQGAAHPVLRTFIRALQSGTRRCPLLERSLKIIIKGLSRVPPQQDNLPSRDVNNSYSNTRLSVATGGAPVNPYIPAFPYLGLEPQFDFGMDPYFNDHNINPMALLDCFPEIQMDNEDIGLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CM23</accession>
    <name>A0A177CM23_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_1162520</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038969.1">
        <property type="nucleotide sequence ID" value="XM_018178015.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CM23"/>
    <dbReference type="STRING" id="1460663.A0A177CM23"/>
    <dbReference type="GeneID" id="28761501"/>
    <dbReference type="InParanoid" id="A0A177CM23"/>
    <dbReference type="OrthoDB" id="1879366at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08297">
        <property type="entry name" value="CAD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:001796">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940:SF2">
        <property type="entry name" value="DEHYDROGENASE FAMILY OXIDOREDUCTASE, PUTATIVE (JCVI)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="7">
        <location>
            <begin position="16"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAG08604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="350" mass="37026" checksum="214EC91D3B93E9C7" modified="2016-09-07" version="1">MSIPSTQTVAWIEDPGPSGKLTIRSGASIQEPSQDEVLVKLECSGICHSDCRNIFGMGKYTEIPGHEGVGEVVKLGPGAKESLKGKRVGIKWLYSSCKECSACKKGNINNCAKQSNTGRTTLGTLQQYVVAHADFISLIPDGVKSEVAAPLLCAGLSLAGAVSKLAPEVEPGEFVVIVGAGGGLGHIGVQIATIKGFKVIAIDSGSDKEQLAKEMGAVAFIDYAKENVVQAVKDLTDGEGAHGLICVAGSERAYQQAPELIRSNGVFVCVGLPPDDFMFPMSPIHIANRGLVIRGSSTGTSEQMDELLQLAKEGKITPKIEVYDFEESPNIIQELDKYEVTGRKVVRAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CM32</accession>
    <name>A0A177CM32_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1203503</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038367.1">
        <property type="nucleotide sequence ID" value="XM_018181835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CM32"/>
    <dbReference type="STRING" id="1460663.A0A177CM32"/>
    <dbReference type="GeneID" id="28765321"/>
    <dbReference type="InParanoid" id="A0A177CM32"/>
    <dbReference type="OrthoDB" id="2910287at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008058364" evidence="1">
        <location>
            <begin position="18"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG08002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="116" mass="12043" checksum="1D36734DF3DD8D64" modified="2016-09-07" version="1">MQLIVTTVLALLGAASAAPARNIQARDGITITFYPEANFGGEPTVVSDVVSNQCQQVPEGVTVGSVKVASGGLCRLTYSAPTCTLHGDVFVFPDTPAEDLTGETVTSFLCQTCTEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CN88</accession>
    <name>A0A177CN88_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nitrogen regulatory protein areA GATA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1162621</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039121.1">
        <property type="nucleotide sequence ID" value="XM_018178044.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CN88"/>
    <dbReference type="STRING" id="1460663.A0A177CN88"/>
    <dbReference type="GeneID" id="28761530"/>
    <dbReference type="InParanoid" id="A0A177CN88"/>
    <dbReference type="OrthoDB" id="5563539at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042149">
        <property type="term" value="P:cellular response to glucose starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007039">
        <property type="term" value="P:protein catabolic process in the vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013860">
        <property type="entry name" value="AreA_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052292">
        <property type="entry name" value="Glucose_repression_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28051">
        <property type="entry name" value="PROTEIN MTL1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28051:SF1">
        <property type="entry name" value="PROTEIN MTL1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08550">
        <property type="entry name" value="GATA_AreA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitrogen regulatory protein areA GATA-like" evidence="2">
        <location>
            <begin position="164"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="359"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="52"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="424"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="439"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="454"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG08756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="569" mass="63175" checksum="D7FCB2E571DE1666" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CNU5</accession>
    <name>A0A177CNU5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CC84DRAFT_1215047</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038925.1">
        <property type="nucleotide sequence ID" value="XM_018182691.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CNU5"/>
    <dbReference type="GeneID" id="28766177"/>
    <dbReference type="InParanoid" id="A0A177CNU5"/>
    <dbReference type="OrthoDB" id="196103at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010291">
        <property type="entry name" value="Ion_channel_UNC-93"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051617">
        <property type="entry name" value="UNC-93-like_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23294:SF57">
        <property type="entry name" value="CINA C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23294">
        <property type="entry name" value="ET TRANSLATION PRODUCT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05978">
        <property type="entry name" value="UNC-93"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="77"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="106"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="140"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="230"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="262"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="297"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="335"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="405"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAG08560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="458" mass="50064" checksum="87F627DA4C14697F" modified="2016-09-07" version="1">MVLQRLKTIYRSVLFQIVIVGLVAFCEPGIWTALNNLGAGGNAKPFLNNAANALTYGLMSIGCFISGGISNKITAKWTLVIGAAFYTPYAAGLYCNNRYGNEWFMLLGAALCGIGASMLWASEAAIAVGYPEDKKRGRYVGIWMGIRQMGPLVGGAISLALNVKTKEKGKVTYTTYLGLVAISSLGAPFALLLSQPQKVNRSDGTKIPYMKKTTFKTEARAIFRQLKNPYMLLLIPVFLAGQFGVTYQGNYLTTYFTVRSRALASFLTAVVGALANLLTGIVLDLPQFSRPAKSKAVYIFVLVTVTASWIWNAVVQTRLTRMADAPSFDLGDGPFFNSAFTVYMSFRFFYEILQTYIYWLMAEIKGAQGDGDVSRTTGILRSWESIGSTIAYAIGAVHIPNQTQMIVGFALWAWTVPFTLMAVFGDWNKGVPKNGLGSDSESESDLEVQRVVTADQKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CNY0</accession>
    <name>A0A177CNY0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1240641</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039276.1">
        <property type="nucleotide sequence ID" value="XM_018184026.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CNY0"/>
    <dbReference type="GeneID" id="28767512"/>
    <dbReference type="InParanoid" id="A0A177CNY0"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG08911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="181" mass="19882" checksum="9E395486FA54A8D8" modified="2016-09-07" version="1">MVARLEADNEDQEDIADDEIPGVLDCGYYTLVPDENGEILVPMGGNKSLSDDFDDGAGAWKKKSAPEPMAGGWNDASFPRHKHLELYEEIMADSGINNASKGEIIYQYRPHKFRNAARVQHQEKENKTDEGIREPATGVGERKSESESVTSGDGHGDENEDGDEDHVAAGGQKMCNKEDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CPC1</accession>
    <name>A0A177CPC1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">cystathionine gamma-lyase</fullName>
            <ecNumber evidence="4">4.4.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Gamma-cystathionase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CC84DRAFT_601458</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-cysteine biosynthesis; L-cysteine from L-homocysteine and L-serine: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the trans-sulfuration enzymes family.</text>
    </comment>
    <dbReference type="EC" id="4.4.1.1" evidence="4"/>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG09061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039426.1">
        <property type="nucleotide sequence ID" value="XM_018186845.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CPC1"/>
    <dbReference type="FunCoup" id="A0A177CPC1">
        <property type="interactions" value="488"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CPC1"/>
    <dbReference type="GeneID" id="28770331"/>
    <dbReference type="InParanoid" id="A0A177CPC1"/>
    <dbReference type="OrthoDB" id="3512640at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004123">
        <property type="term" value="F:cystathionine gamma-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019343">
        <property type="term" value="P:cysteine biosynthetic process via cystathionine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00614">
        <property type="entry name" value="CGS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000043">
        <property type="entry name" value="Cystathionine gamma-lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000008">
        <property type="entry name" value="Cystathionine gamma-synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11808:SF15">
        <property type="entry name" value="CYSTATHIONINE GAMMA-LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11808">
        <property type="entry name" value="TRANS-SULFURATION ENZYME FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001434">
        <property type="entry name" value="CGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0198">Cysteine biosynthesis</keyword>
    <keyword evidence="10" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 8 9" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="8">
        <location>
            <position position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001434-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAG09061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="418" mass="44671" checksum="22FCBDEF7453C42F" modified="2016-09-07" version="1">MTLAEHPIETPPRAPSPVHRFGTLAVHAGSPHDPVTGAVIEPISLSTTFAQTSLGKPVGQYEYSRSSNPNRDNFERAIAALEHARFALAFSSGSATTANILQSLAAGSHVISVSDVYGGTHRYFTKVALTHDVKVTFSPSIEIDIAELITPETKLIWIESPSNPTLTLVDIRKVATIAHQHGILVVVDNTFLSPYVQNPLDHGADIVVHSVTKYINGHSDVVMGAAAFNSQDIYDRLSFLQNALGAVPSAFDCWLAHRGLKTLHLRAREATKNATGVATALKNSPHVVAVNYPGLPSHPQYAVTQKQHRDAMGGGMLSFRIRGGHEAAERFCQATKIYTLAESLGGIESLVEVPSAMTHGGIPREQREAAGVFDDLVRVSCGIEDEADLVADVLQALEKAVVGPKITNALTSNGNGHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CPE6</accession>
    <name>A0A177CPE6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1215268</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039163.1">
        <property type="nucleotide sequence ID" value="XM_018182710.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CPE6"/>
    <dbReference type="STRING" id="1460663.A0A177CPE6"/>
    <dbReference type="GeneID" id="28766196"/>
    <dbReference type="InParanoid" id="A0A177CPE6"/>
    <dbReference type="OrthoDB" id="3801390at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="225"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="235"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="265"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="280"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="292"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="303"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG08798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="386" mass="42079" checksum="F22A2B15512F073D" modified="2016-09-07" version="1">MSDVENPPSPPVVEIAQPADPTPTNEEPPVPPPPTPAAEEAPQPILPEDTMAITTEDGKPIEAIVTESAEEGVATVEAILEPEPEPEPPQPEEEPPKGPEPEPEPEKEPEPEPPVEEQAEPEPGTPTKEKVEEEPQSKPSPGKEEPPFGPPVERIADPEPEPEPEKEPEPKSEPEKEPEPEEPLSAEVEAEEDPPQEESAPEPVEKKVEEEPRPELEPAANVDPSVEEPVEEEPQLEREPEPEALAEKEKPETLPPIVERKAEEESQPEPEPGPEPDSPLEERKEGSPAEEVKEEEPVVEAVEEPKAEEPPPAEESKAEEEKEKPAPAPEPLKRKKRDAVRAKAVPKFPIKLIAGREIGAAAVFLMKEKAKGVDIKPQLDALMKGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CPJ8</accession>
    <name>A0A177CPJ8_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Large ribosomal subunit protein bL21m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_1162588</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL21 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039074.1">
        <property type="nucleotide sequence ID" value="XM_018178033.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CPJ8"/>
    <dbReference type="FunCoup" id="A0A177CPJ8">
        <property type="interactions" value="184"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CPJ8"/>
    <dbReference type="GeneID" id="28761519"/>
    <dbReference type="InParanoid" id="A0A177CPJ8"/>
    <dbReference type="OrthoDB" id="5994at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028909">
        <property type="entry name" value="bL21-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036164">
        <property type="entry name" value="bL21-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21349">
        <property type="entry name" value="50S RIBOSOMAL PROTEIN L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21349:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL21M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00829">
        <property type="entry name" value="Ribosomal_L21p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141091">
        <property type="entry name" value="L21p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="48"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="59"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00044129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAG08709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="238" mass="26184" checksum="B17CD1A3792E68CC" modified="2016-09-07" version="1">MALFARTLRASLPSARPALQSARGLTTVSHTLETGNVPDALLHSNQHTSSNLEQKVDSPPAPPHTPPSPAAPAAPNARQDVVATHLTPSIRQLLPLLTSQPAHYITAHIHGRPYLLTPGDTLRLPFLMPNVEAGDVLRLNRATHIGSRDYTLKAPAAIKGTADHGKIVHYLDERLFTCRATVVGVESEPMRVMEKTKRRQRHVKHVFSKHKYTVLRVGEVEVKTLEQYEEALKNDGDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CQI2</accession>
    <name>A0A177CQI2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_453364</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG09775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040140.1">
        <property type="nucleotide sequence ID" value="XM_018186327.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CQI2"/>
    <dbReference type="GeneID" id="28769813"/>
    <dbReference type="InParanoid" id="A0A177CQI2"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG09775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="151" mass="16495" checksum="2843E8604EDB7A34" modified="2016-09-07" version="1">MRARHPQTLYLDTLEPHVSALNGLRRNSQTREAIEDALAALLGMVYIWRARVRRPTDAGRRRQAQAPARPSIPSLALQRLRPPAYGSHCIVTCSFTPLLAVYLAAFVPCNHKATCSIGFSGGTIARTGSLEVGAANIVNKSRAQLRIRSPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CR48</accession>
    <name>A0A177CR48_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF1753-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1138089</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG09985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040350.1">
        <property type="nucleotide sequence ID" value="XM_018176180.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CR48"/>
    <dbReference type="STRING" id="1460663.A0A177CR48"/>
    <dbReference type="GeneID" id="28759666"/>
    <dbReference type="InParanoid" id="A0A177CR48"/>
    <dbReference type="OrthoDB" id="3338076at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070916">
        <property type="term" value="C:inositol phosphoceramide synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070917">
        <property type="term" value="F:inositol phosphoceramide synthase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006673">
        <property type="term" value="P:inositol phosphoceramide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013862">
        <property type="entry name" value="Kei1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28077">
        <property type="entry name" value="INOSITOL PHOSPHORYLCERAMIDE SYNTHASE REGULATORY SUBUNIT KEI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28077:SF1">
        <property type="entry name" value="INOSITOL PHOSPHORYLCERAMIDE SYNTHASE REGULATORY SUBUNIT KEI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08552">
        <property type="entry name" value="Kei1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="57"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="87"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="185"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="284"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="291"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG09985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="333" mass="35930" checksum="ED94D4812099E047" modified="2016-09-07" version="1">MAPSQLFELPRPKNFFQKMSLRTGAEIITYLQVINKVSGLYGLLALLTGAAIDGWQLSMYLYSTVVLVATVYLYTHIRMQSSFESLLLAHLYALDSVVNALYTAFFGFVWFYTLANHPGGSDNSIAPGLGENAGFTSPKYNVSEVNVVAEPVGGIKAGQDAVAVGQGTPGSAPGLSGAVFQTSSIMSLSLIAGFWALRVYFVFVMLAFARQCLRQHIAANASTAGWYNNDTPQTSQNLAENPFQESKEAGAGWRGKLGRAMLSGAPLYWLGSSAEEDESWMRGVGGKFSKKGASAGEPIGLGERERRRRSGTGPPAPPREMRPPQLADLQEVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CR93</accession>
    <name>A0A177CR93_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Sensor histidine kinase-like protein/response regulator</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_433275</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG09289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039654.1">
        <property type="nucleotide sequence ID" value="XM_018186236.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CR93"/>
    <dbReference type="STRING" id="1460663.A0A177CR93"/>
    <dbReference type="GeneID" id="28769722"/>
    <dbReference type="InParanoid" id="A0A177CR93"/>
    <dbReference type="OrthoDB" id="303614at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.130:FF:000023">
        <property type="entry name" value="Sensor histidine kinase/response regulator, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050956">
        <property type="entry name" value="2C_system_His_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43719:SF11">
        <property type="entry name" value="HISTIDINE KINASE_RESPONSE REGULATOR, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43719">
        <property type="entry name" value="TWO-COMPONENT HISTIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55781">
        <property type="entry name" value="GAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1 4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase" evidence="6">
        <location>
            <begin position="523"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="7">
        <location>
            <begin position="1044"/>
            <end position="1165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="239"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="321"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="410"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="966"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="240"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="257"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="333"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="352"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="410"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="966"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="4">
        <location>
            <position position="1095"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAG09289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1178" mass="129775" checksum="E703F756C1D3D925" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CRP4</accession>
    <name>A0A177CRP4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1213023</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG09612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039977.1">
        <property type="nucleotide sequence ID" value="XM_018182496.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CRP4"/>
    <dbReference type="GeneID" id="28765982"/>
    <dbReference type="InParanoid" id="A0A177CRP4"/>
    <dbReference type="OrthoDB" id="3508922at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008058511" evidence="1">
        <location>
            <begin position="17"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG09612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="162" mass="17818" checksum="BEBA014AA6E894E7" modified="2016-09-07" version="1">MVSFTTLLALSAGALSSPVVQRQIAIPENWNWHVSGWEAGCARSGCYYNFNVTVPTVEGQIAGVKAYCNGYENGYYRKGNWYENCQILEGVNNGVAAKLSERPPESDTESTLPQEILISFVLAGYEDRPAYNFTGSHKTIYNQFAAPLQEFDVTPTTVFGVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CS92</accession>
    <name>A0A177CS92_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Acid protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CC84DRAFT_483491</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040768.1">
        <property type="nucleotide sequence ID" value="XM_018186457.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CS92"/>
    <dbReference type="STRING" id="1460663.A0A177CS92"/>
    <dbReference type="GeneID" id="28769943"/>
    <dbReference type="InParanoid" id="A0A177CS92"/>
    <dbReference type="OrthoDB" id="4074350at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF51">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008058527" evidence="4">
        <location>
            <begin position="25"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="434"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="5">
        <location>
            <begin position="44"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="407"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="561"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="413"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="582"/>
            <end position="593"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAG10403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="602" mass="65351" checksum="774002B39916A453" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CS93</accession>
    <name>A0A177CS93_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1202310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG09629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039994.1">
        <property type="nucleotide sequence ID" value="XM_018181765.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CS93"/>
    <dbReference type="STRING" id="1460663.A0A177CS93"/>
    <dbReference type="GeneID" id="28765251"/>
    <dbReference type="InParanoid" id="A0A177CS93"/>
    <dbReference type="OrthoDB" id="3565018at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35186">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35186:SF4">
        <property type="entry name" value="PRION-INHIBITION AND PROPAGATION HELO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG09629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="256" mass="29076" checksum="8A14D6261D06EA1C" modified="2016-09-07" version="1">MDSTRKTGLEAASHSNTGRLSRTRQMQEIKSTCCSGMRDWIVDGGCFGQCLHLEDRSHATTLESIFFDGHRGGVDERNFRLKQRLLHAKALTSTLPQLQSMQWLSSVWGKSDVSFVSSDSVLPPTTTKLYIGKIFPSDTHVPSMPQEYCERSLQCLKFISLELTFKKGLEALSLRKRYLGQDRQLTEFTDHNTAKSLQTEFEGGCGDFMLDMVGRCLNCSFRLQPGWNSKDFLNAYRTHVLEPFEKILAAWSNMKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2024-01-24" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CSZ0</accession>
    <name>A0A177CSZ0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_455591</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG09859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040224.1">
        <property type="nucleotide sequence ID" value="XM_018186342.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CSZ0"/>
    <dbReference type="GeneID" id="28769828"/>
    <dbReference type="InParanoid" id="A0A177CSZ0"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG09859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="104" mass="11623" checksum="EC592AB045DB8B03" modified="2016-09-07" version="1">MERCRIVHPTQPGRTPEHTSTMAETIDRNMDDKMEFSTSKEVTVAPTTKTVAVVADRLFRFGRLRPTVDITSVKLIAPSAMQSTTGLCFECEEEFEVVLLFGQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CTF9</accession>
    <name>A0A177CTF9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">3-oxoacyl-[acyl-carrier-protein] reductase</fullName>
            <ecNumber evidence="2">1.1.1.100</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_1255944</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a (3R)-hydroxyacyl-[ACP] + NADP(+) = a 3-oxoacyl-[ACP] + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17397"/>
            <dbReference type="Rhea" id="RHEA-COMP:9916"/>
            <dbReference type="Rhea" id="RHEA-COMP:9945"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78776"/>
            <dbReference type="ChEBI" id="CHEBI:78827"/>
            <dbReference type="EC" id="1.1.1.100"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.100" evidence="2"/>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040404.1">
        <property type="nucleotide sequence ID" value="XM_018184584.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CTF9"/>
    <dbReference type="STRING" id="1460663.A0A177CTF9"/>
    <dbReference type="GeneID" id="28768070"/>
    <dbReference type="InParanoid" id="A0A177CTF9"/>
    <dbReference type="OrthoDB" id="498125at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004316">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050259">
        <property type="entry name" value="SDR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42879">
        <property type="entry name" value="3-OXOACYL-(ACYL-CARRIER-PROTEIN) REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42879:SF2">
        <property type="entry name" value="3-OXOACYL-[ACYL-CARRIER-PROTEIN] REDUCTASE FABG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00048508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAG10039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="104" mass="10823" checksum="EA95E8DDE474D143" modified="2016-09-07" version="1">MGIGQSRIKGFSVWGNGAAMARALSQNGVKLVGCDPSLEAAQFSASRLREEGGACGVMTANVPSSADVRSVVEAAMQQYGCIEILVNNVGMTWPGNPARIPEEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CTJ6</accession>
    <name>A0A177CTJ6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Delta-12 fatty acid desaturas-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_1184580</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040971.1">
        <property type="nucleotide sequence ID" value="XM_018180758.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CTJ6"/>
    <dbReference type="STRING" id="1460663.A0A177CTJ6"/>
    <dbReference type="GeneID" id="28764244"/>
    <dbReference type="InParanoid" id="A0A177CTJ6"/>
    <dbReference type="OrthoDB" id="1461976at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03507">
        <property type="entry name" value="Delta12-FADS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012171">
        <property type="entry name" value="Fatty_acid_desaturase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32100">
        <property type="entry name" value="OMEGA-6 FATTY ACID DESATURASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="48"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="83"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="118"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="242"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="271"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid desaturase" evidence="3">
        <location>
            <begin position="88"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="421"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAG10606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="449" mass="51047" checksum="3ACA745A761F4ECE" modified="2016-09-07" version="1">METERTGFNTHKEPHPSELLDAGTLNSNELSIRQLRTAIPSYCFEPSLFWSFFYLIRDISYSAILLSTLWYCLTLPQVEQSSLLYYTLVCSYGVCQGIVWTGLWVIAHDAGHSGFSKIPLLNDTVGFVLHSFLLAPYFSWKSSHRRHHIYANHIERDLNYVPPQRSEYARQIGAALDKIDEVGEDAPVVLTLRIILQQLIGWNWYILSNITTPDTAVVKKGLSVWRYSHFDPWGGMFRDSEVTAIILSDIGCLSTISGLYVLYRYLGSFELLFWVYVVPWCVVNHFIVMITFLHHTHPDVPKYTADSWTFLRGATATIDRDFGIIGTHFFHHISSDHVTHHLFSSIPHYYSRTASKAIIPLLGAHYHGRGTFTYNDLKTSFRDCQWVEEDAARDRHFGIGDGNGREKRALWYRKGISPAPENAFPGAPGTSVSTAGHASRHSLHDSLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CTV6</accession>
    <name>A0A177CTV6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative paraoxonase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1193818</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040695.1">
        <property type="nucleotide sequence ID" value="XM_018181325.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CTV6"/>
    <dbReference type="GeneID" id="28764811"/>
    <dbReference type="InParanoid" id="A0A177CTV6"/>
    <dbReference type="OrthoDB" id="5307922at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051288">
        <property type="entry name" value="Serum_paraoxonase/arylesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11799">
        <property type="entry name" value="PARAOXONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11799:SF30">
        <property type="entry name" value="SERUM PARAOXONASE_ARYLESTERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG10330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="388" mass="42714" checksum="FFD455532F740403" modified="2016-09-07" version="1">MAATTKIALSTLAIAVLGPYCYDRYLALSTIVRNRPGHYEPINIFKGHEIKFRDTHDFRNCEDLLLSEVRGVAILSCDPGRDRWNTVMGTFRPDENLTSGSLWLYDYTSTELGSNDSIKQLAFNDFPHEGDFHPIGMDLDKETSILYVVNHAQSGSCIETFRLEANTLIDIKTITHPLLHAPNSIESVGDGSLYVTNDHMFRSRVSPVLSKFETFSGLPGGTIVHIDLNRTEGAQVVARVPFANGIARLNSTTLAVASSSKPGLYLYGMQLDHSLNFKGMFRTPAAVDNLSVDSEGTLLMAGHPSALELMKISKGRPLCSPNSDSEAERIACDCTAPSWAAQWSEEKGLETLFQGSYFCSSSTMVRDVKRGISLISGLYERGIMVINE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2023-06-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CUH8</accession>
    <name>A0A177CUH8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1161719</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041261.1">
        <property type="nucleotide sequence ID" value="XM_018177817.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CUH8"/>
    <dbReference type="GeneID" id="28761303"/>
    <dbReference type="InParanoid" id="A0A177CUH8"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG10896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="94" mass="10477" checksum="8F0CF2B43F510259" modified="2016-09-07" version="1">MAQRARDEIDFILAQAAATQGEGPPRPDKAAAQADINTWQRWHRVRGTFISMFGHDVFAKHEDATGNPSDVPPGQPKGFARQLTRGQYMTLEKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CUS6</accession>
    <name>A0A177CUS6_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">COP9 signalosome complex subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CC84DRAFT_1158838</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CSN3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG11273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041638.1">
        <property type="nucleotide sequence ID" value="XM_018177080.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CUS6"/>
    <dbReference type="STRING" id="1460663.A0A177CUS6"/>
    <dbReference type="GeneID" id="28760566"/>
    <dbReference type="InParanoid" id="A0A177CUS6"/>
    <dbReference type="OrthoDB" id="29061at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008180">
        <property type="term" value="C:COP9 signalosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055089">
        <property type="entry name" value="COP9_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050756">
        <property type="entry name" value="CSN3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10758">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 3/COP9 SIGNALOSOME COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10758:SF1">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22788">
        <property type="entry name" value="COP9_hel_rpt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0736">Signalosome</keyword>
    <feature type="domain" description="COP9 signalosome complex subunit 3 N-terminal helical repeats" evidence="9">
        <location>
            <begin position="54"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="PCI" evidence="8">
        <location>
            <begin position="335"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF22788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAG11273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="501" mass="55665" checksum="DA5C0D7BB0B6449D" modified="2016-09-07" version="1">MSAETITSLLSFQPDAPELQQKREYDKEAREFTKLVNGLTPATFLKGADSPQDPLNVLEPATNSIAYAFTLRHRIEAANKKSVDQLRPGASLWNKLVLFLESFDPVQMRYAGEQWRKLVEYVELIARNEGAPALAIAPIRSAMFRLDPTTGTFTSTHLRFIQLCMETRSYKAALPVLDNYIHSLPTVIAKETLEDLEYSVMAADSVASGEFINLKSGHTAKISLTDLQEYYVLGAMAYLGERRVYDALYFLEHVLVTPTNNALNGLMLEAYKKWVLISCLADRSHKTPPRTMSSTAVKNCRNAAKAYEALAEAFQQVNNLPKLKAQVNAGRDIWAEDGNTGLVEELLEHQNRAYLSRLSRTYSAIPVSNIARNVGSSADQVTTFVDSLIRQGLLNAQLEANDKSGAGAVLRFYLDPTQGPLAKTEKQQQQALFEQTQRTNALAEQVRDADYRLSITKEYVEYLKRQKKKNGAGAGGGAGVDAMDMGFEDGDLDEDIMGDLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CV95</accession>
    <name>A0A177CV95_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CBD9-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1237730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041082.1">
        <property type="nucleotide sequence ID" value="XM_018183914.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CV95"/>
    <dbReference type="GeneID" id="28767400"/>
    <dbReference type="InParanoid" id="A0A177CV95"/>
    <dbReference type="OrthoDB" id="413885at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09630">
        <property type="entry name" value="CDH_like_cytochrome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1210">
        <property type="entry name" value="Cellobiose dehydrogenase, cytochrome domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015920">
        <property type="entry name" value="Cellobiose_DH-like_cyt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005018">
        <property type="entry name" value="DOMON_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47797:SF5">
        <property type="entry name" value="CELLOBIOSE DEHYDROGENASE CYTOCHROME DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47797">
        <property type="entry name" value="DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G05805)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16010">
        <property type="entry name" value="CDH-cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00664">
        <property type="entry name" value="DoH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49344">
        <property type="entry name" value="CBD9-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DOMON" evidence="1">
        <location>
            <begin position="74"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG10717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="225" mass="23721" checksum="916E6F93A4AD34AD" modified="2016-09-07" version="1">MKVTAFGRPSTGVQPRAEGTITYVDQETGFTFSEYKAAFSLSANIVFRFALPSNAPSGPYNAVIQAVVPNQLGWIGLAWGGNMVKNPLTVAYPNGQKATVSSRWATGHSTPMAYTGATYTLLNTGNKVNGSHWQFTAKCAGCTTWTGSSGSVRISPTGSSRLAFAYSTGKASSPSSNTSTIPVHDTPNYFTNDFSQGQNPNFDALLARNGVSAAREGVVFVDGPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CVP1</accession>
    <name>A0A177CVP1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7730 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1161693</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041222.1">
        <property type="nucleotide sequence ID" value="XM_018177806.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CVP1"/>
    <dbReference type="STRING" id="1460663.A0A177CVP1"/>
    <dbReference type="GeneID" id="28761292"/>
    <dbReference type="InParanoid" id="A0A177CVP1"/>
    <dbReference type="OrthoDB" id="4757095at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056632">
        <property type="entry name" value="DUF7730"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38790">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24864">
        <property type="entry name" value="DUF7730"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7730" evidence="2">
        <location>
            <begin position="92"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG10857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="337" mass="38787" checksum="B091234AF465BD2C" modified="2016-09-07" version="1">MANRRTKATTIALGLACAPFLCCWIIIASCCCPRRLHPHGESGEKRRFEKRQTMAPRPLPVRPPERALTMRRRTAEPESEVQPQTPRGVTRNQSASRLMQLPLELRQIIYRAAIGDSVMHMVTKKYKLGHQRCKAPTIAECPEQYSFFSPDNVWSPLGEPLDNPPATDGDILPLLLTCRQIYSESIEYLYSTNTFSFSDLDCLRYFSSTILPHRWSLVQNIDIEWCISWPIYDPLAQALLISRPALYPPHDEATWEGTWRIIGQMPSLKWLRVRLMYFDGFRDSACEEKLLAPLRQVTLPRTFTVHLNWAGEEIEGAPFRAIRPGTRESLFPDEEWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CVT1</accession>
    <name>A0A177CVT1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">EamA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_12844</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG11346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041711.1">
        <property type="nucleotide sequence ID" value="XM_018185358.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CVT1"/>
    <dbReference type="GeneID" id="28768844"/>
    <dbReference type="InParanoid" id="A0A177CVT1"/>
    <dbReference type="OrthoDB" id="306876at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22911">
        <property type="entry name" value="ACYL-MALONYL CONDENSING ENZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22911:SF6">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER G1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="84"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="143"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="241"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="271"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="303"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="335"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="360"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="7">
        <location>
            <begin position="53"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="7">
        <location>
            <begin position="247"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="385"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAG11346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="417" mass="45215" checksum="8086122731A132C2" modified="2016-09-07" version="1">MGGSRSYGATSAAGPDDNRSTPAVTDHQVQDAEEQTQHPSARRKLKQFYERNFGLFLVFLAQTCGSVMNTAAKLLATGYETKFHALQIIFVRMSCTTILSCLYIWYNRIPRSQGVTGLLILRGTAGFIGLFGLYYSLSWLEFADATVITFIVPTMTALVCWVWLREPYTVKEALAGLLAFTGVLFVARLAWLFRSAPLDPISGEPAEPVEGPDSSSLSLLSFGILGGKAPSLPPVSAEQRTIAIILAVLGTFGASTAYATIRVIGKRAHSLISVTYFAFLSTIGSALIILVHPDLQFVMPEDLSQWGLIAIIGLAGFALQFLLTEGLQREKGGRATNLTYLQLVFALIVERLVWGTTPPLESLFGAVLIIGAAVWVSLQKNAVKEKGSKAVDEESSLLGDEQGENEVRRRSLASAEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CW83</accession>
    <name>A0A177CW83_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Six-hairpin glycosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1182423</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 88 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG11471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041836.1">
        <property type="nucleotide sequence ID" value="XM_018180631.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CW83"/>
    <dbReference type="GeneID" id="28764117"/>
    <dbReference type="InParanoid" id="A0A177CW83"/>
    <dbReference type="OrthoDB" id="2317065at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052757">
        <property type="term" value="F:chondroitin hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052369">
        <property type="entry name" value="UG_Glycosaminoglycan_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36845">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G05090)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36845:SF1">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G05090)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG11471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="462" mass="51996" checksum="33038FD9A3EA9B03" modified="2016-09-07" version="1">MDTSDAAFVVDRHLPDLFTENITAKALRTAQTAIKALPDFFPEYVPQDAGQGGRYTLREADFWTCGFFPGTLYTILERAVRFPQSLQLPPEISILQFREQLLTLCRTWAEPLYNMDTRTDTHDIGFIIMPALQLDWELFGNRKSLDSIVRAARSLASRYIPSARAIRSWDILKTRDMEILDQEDNMIVIIDSMCNLDLMYYAAHHTQDPSLAEMATAHAETLLRSHLRPEHVVLSNKPKVCYTGPWYSTCHVANIDPKSGTLKQRLTAQGYAHESNWARGQAWAILGYAQAYLSTKDWRFLHASCGLAEYFLYRLETTPAYATPGRYVPLWDFDAPIDDETNIVRDSSAGMIAANGMLILSQALAGFGSGMLASRFRETAMMIVQDTISFALAPETATLVCASNGYISAEDSTPGWSFEGMLKYGTANNNEQARKRYANHGLVYGDYYLVQFGNRLMKMGIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CWE5</accession>
    <name>A0A177CWE5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">UPF0187 domain membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CC84DRAFT_1046110</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG11190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041555.1">
        <property type="nucleotide sequence ID" value="XM_018173414.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CWE5"/>
    <dbReference type="STRING" id="1460663.A0A177CWE5"/>
    <dbReference type="GeneID" id="28756900"/>
    <dbReference type="InParanoid" id="A0A177CWE5"/>
    <dbReference type="OrthoDB" id="1368at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044669">
        <property type="entry name" value="YneE/VCCN1/2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33281">
        <property type="entry name" value="UPF0187 PROTEIN YNEE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33281:SF19">
        <property type="entry name" value="VOLTAGE-DEPENDENT ANION CHANNEL-FORMING PROTEIN YNEE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25539">
        <property type="entry name" value="Bestrophin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="16"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="262"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="287"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAG11190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="385" mass="43298" checksum="FFDCAF0F4216E42E" modified="2016-09-07" version="1" fragment="single">YQLGPRELDKHSKWPMLLMIHGSCLPELIIPLLFVGAWTTGICLFSRHVHDVGIATTLLTVLGFIVALSLSFRSSTAYERYMEGRRAWTQLTMVSQNLARNIWVNAVEREESAKDDLLSKVTALNLIVAFAQALKHRLRFEPYTHYRDLKDLVGHLDTFANEATELETHRDEDPPTFWESWGDYLAIPMLTSNPRKTIKRARYPLGNLPLEILNHLGVHIHSLIACGCFRANGYQAQALNAILALNDIQANTDRILNTPLPLAYAIAISQLTWVYILILPFQLYSTLGMLAIPGTLLAAYMILGFASIGREIENPFGHDVNDLPLDDFCAQLAVDIDIIAAMAPKDADTFVKSDKNQLMHPLSRSGYEAWSESSVDEIRDALKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CWP2</accession>
    <name>A0A177CWP2_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">beta-fructofuranosidase</fullName>
            <ecNumber evidence="2">3.2.1.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CC84DRAFT_1077873</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 32 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.26" evidence="2"/>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG11965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042330.1">
        <property type="nucleotide sequence ID" value="XM_018173777.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CWP2"/>
    <dbReference type="STRING" id="1460663.A0A177CWP2"/>
    <dbReference type="GeneID" id="28757263"/>
    <dbReference type="InParanoid" id="A0A177CWP2"/>
    <dbReference type="OrthoDB" id="202537at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004564">
        <property type="term" value="F:beta-fructofuranosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051214">
        <property type="entry name" value="GH32_Enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001362">
        <property type="entry name" value="Glyco_hydro_32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013148">
        <property type="entry name" value="Glyco_hydro_32_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43101">
        <property type="entry name" value="BETA-FRUCTOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43101:SF1">
        <property type="entry name" value="BETA-FRUCTOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00251">
        <property type="entry name" value="Glyco_hydro_32N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00640">
        <property type="entry name" value="Glyco_32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyl hydrolase family 32 N-terminal" evidence="5">
        <location>
            <begin position="26"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAG11965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="485" mass="54384" checksum="C97D2DD24004B4B2" modified="2016-09-07" version="1">MPSRTVPPSTWYSRPSTSQAAADAIPILVDDEYHVFHLSTPPNTIRHPPRLRSSWSRLRSRDLLKWERDQTEVLIPGKTRDSPDADGAWTGCAILGPDGNMHIFYTGYNLSQDGKQVILHARSDDKKGTKFTKTPCPISITGDLSRFEDIDFRDAHVSRQESENCYWMLVATRLRTGPFWTRGCLALLTSPDLEAWTIDPRPFYAPNDIFCPECPELFSLPNGKWWYAAKSCPKAGDPSKRIYFGWVADKFDGQWSWGGDMAMPREVFADKNGQLVVQPCPEFLRAMFAPCSEVPIPTSISISSLGETKISSLSAMESVPNEYHLNFQVAASDAASFGLIFRTSKDMDGHRLRMTPASPYLCDVVLAKYPAPLDDFWADQYKMHLPREVDGPEIARHLVDIRGNICITVKSNVLEIFVGGKSISYRLPGASDSNNKFTIEANGHENGQTREPLLNGIAEVMQELSVFVEDGSLQLMDVRLRARTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CXS3</accession>
    <name>A0A177CXS3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Clavaminate synthase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1159687</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042720.1">
        <property type="nucleotide sequence ID" value="XM_018177297.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CXS3"/>
    <dbReference type="STRING" id="1460663.A0A177CXS3"/>
    <dbReference type="GeneID" id="28760783"/>
    <dbReference type="InParanoid" id="A0A177CXS3"/>
    <dbReference type="OrthoDB" id="408743at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050411">
        <property type="entry name" value="AlphaKG_dependent_hydroxylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696">
        <property type="entry name" value="GAMMA-BUTYROBETAINE HYDROXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696:SF21">
        <property type="entry name" value="TAUD_TFDA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="2">
        <location>
            <begin position="61"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG12355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="383" mass="42845" checksum="6E30AA5853C4C832" modified="2016-09-07" version="1">MASPFAHFDKITLSSQQSTAKLGYPSSHPFPLALSVKQDWNPTLEEATSHLSSLSQSGSLFSLLHENGGAVLLRGLPIRTPDDYSRIAHSFGFAPHEEVGRPPIRTVLAPNVKTANEGPPELPIWPHNEYGWSTHNPSWLTFCCLEVPESGGATPIISSIGLAHRLEQEAPAFFARLLEKGVKYVYRYGREQVESNTGASVFAAYGQHVEDEDSEEVIREKIEKEVRRHSEMFEWHEDGSLSVEHVVPIIRKHLPTGLTTWFGNLTSAYGRARHHGATQPPYRGDDGSYHPPPIYGDGTVIATEDLELALNIAEEMQVDLLWEKGDVVLLDNYAVMHSRRPWVGSRVVLAALWDDIGEKRIIDFEEGRHILESRRHQEKASTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CY35</accession>
    <name>A0A177CY35_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7730 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_124176</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042849.1">
        <property type="nucleotide sequence ID" value="XM_018184063.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CY35"/>
    <dbReference type="GeneID" id="28767549"/>
    <dbReference type="InParanoid" id="A0A177CY35"/>
    <dbReference type="OrthoDB" id="62952at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056632">
        <property type="entry name" value="DUF7730"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38790:SF4">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38790">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24864">
        <property type="entry name" value="DUF7730"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7730" evidence="2">
        <location>
            <begin position="6"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="235"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="303"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG12484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="373" mass="42079" checksum="FB28C80BEACB815C" modified="2016-09-07" version="1">MDVAARKKSLLLSLPMELRLEIWRWTLSDPSVPDLVANIGRDKKYVRRDSATGTVIPRVKAWLEPGRNQSIGLGLLRTNKSIYEEALPLLYNAVRFAPTDHQGIFPLFLDSLSPYARSLIHHIKLHVPRQIYDLDLFGAHPDSLFHWAITCAQIAKLEGQLRDVEVEGLWFESRFVNEKTKYSILFPLCKIKTKKVFGPNNDDGMERLLLHASRELARKADLRRNQALLTELKDAVAKDRGETDPEEEDQEKGALENSVGQLEHRNSDMLRQPYSSPITSDDIILRNLSTVAGIDAFEKELKEHTSPVGENSSTDDAATLTDDWDLISYRSGASTPTDRPPTYMSRCSADSWTDVASTIAEVHNLDTDEDVAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CYB1</accession>
    <name>A0A177CYB1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1254525</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042571.1">
        <property type="nucleotide sequence ID" value="XM_018184473.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CYB1"/>
    <dbReference type="GeneID" id="28767959"/>
    <dbReference type="InParanoid" id="A0A177CYB1"/>
    <dbReference type="OrthoDB" id="190201at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008058793" description="AB hydrolase-1 domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="100"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG12206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="391" mass="42421" checksum="09B40F8374607EC3" modified="2016-09-07" version="1">MKAPIQLTLLALAGTSLSKPVSSPEPICRDIKLTVTASADNIDLPPFPNDTSPTAFGRYAQSFNVSNLDTKRVGGTFNIAATYCEPSRKIKGREHIIQFLLHGLGYTKEYWNGLNFPNVTYPGQYSWTHHANSQGYATLAIDNLGDGESDHPDPISMVQLPLQEAIILEIFKSLRNKAISCIPTKYSKIIMVTHSYGALIGRAVATDHPHPATGADAYIQTASSSELKGINAAVLNWAPRAASVVDPARFSHLPPAYLQVAPRAIRETVYGYPGEYDAEVLAWDESLPKPFSIGQILPPKPNTVSSFRGPVIYITGTHDAIVCDRAGNTTLLTTECAAGRDANPGLTAEKFPKARKFVARVVKATGHNVNLHYSAHESFVAAHQLLTKMGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CYE2</accession>
    <name>A0A177CYE2_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1192296</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG11922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042287.1">
        <property type="nucleotide sequence ID" value="XM_018181240.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CYE2"/>
    <dbReference type="STRING" id="1460663.A0A177CYE2"/>
    <dbReference type="GeneID" id="28764726"/>
    <dbReference type="InParanoid" id="A0A177CYE2"/>
    <dbReference type="OrthoDB" id="5280838at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38119:SF1">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38119">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="369"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG11922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="486" mass="55007" checksum="E57327D4DB08C5E1" modified="2016-09-07" version="1">MVSYPDSQGAERSLAIRRPPSVTSHSSRASTVRRHRPHRSHFGGSSYQPQNEFPVFTHTGDVDILISNGRKEQRYLLHKLILAQCSGFFEAGLSDEWATAGESSAQSATSAALARVPQGALQEKKVWKYELEWGRDDDLPMLIQKKAQPTLFGGDGASSQPPALRNKPPAPQAGFFRSMANFSSLHVPTTPTDPDDDTFRDYDNLLRVFYNYPPALDPVNIANAYVECKSLLQIADMYDALDVIGPRVDHHLLRFQGRLWKQIAKYPPSYLKLGYMARSKAIFSEAMVHVVGQWPQGMNQLRGQVAESVLELVEDKVDEMDELKAKVEVKLFRLTLTTSRGERVTPSNNWLEWMAISLFRQWLAENTTPPPAPILKSPRQPSRSGDDTPLPPPPPFNTGRIFKLLGTGGASYLGHDECKRFLKLSPEHYNRDNLKRFERRIEEIKNKAKDAVKPLMRNFLELDLREGGLPYLTCTRIDPHDFPWDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CYM9</accession>
    <name>A0A177CYM9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CC84DRAFT_1159407</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042377.1">
        <property type="nucleotide sequence ID" value="XM_018177225.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CYM9"/>
    <dbReference type="GeneID" id="28760711"/>
    <dbReference type="InParanoid" id="A0A177CYM9"/>
    <dbReference type="OrthoDB" id="2985014at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:001331">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF21">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="47"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="91"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="142"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="224"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="338"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="376"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="408"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="439"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="471"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="502"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="51"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="279"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="285"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAG12012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="601" mass="66905" checksum="520B4AA9A6DA01A2" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CZ32</accession>
    <name>A0A177CZ32_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Xaa-Pro aminopeptidase</fullName>
            <ecNumber evidence="5">3.4.11.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Aminoacylproline aminopeptidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CC84DRAFT_1135031</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of any N-terminal amino acid, including proline, that is linked to proline, even from a dipeptide or tripeptide.</text>
            <dbReference type="EC" id="3.4.11.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase M24B family.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.9" evidence="5"/>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042766.1">
        <property type="nucleotide sequence ID" value="XM_018176042.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CZ32"/>
    <dbReference type="FunCoup" id="A0A177CZ32">
        <property type="interactions" value="502"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CZ32"/>
    <dbReference type="GeneID" id="28759528"/>
    <dbReference type="InParanoid" id="A0A177CZ32"/>
    <dbReference type="OrthoDB" id="4215474at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050821">
        <property type="term" value="P:protein stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01087">
        <property type="entry name" value="Prolidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007865">
        <property type="entry name" value="Aminopep_P_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052433">
        <property type="entry name" value="X-Pro_dipept-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43226">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43226:SF4">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05195">
        <property type="entry name" value="AMP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01011">
        <property type="entry name" value="AMP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0464">Manganese</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminopeptidase P N-terminal" evidence="12">
        <location>
            <begin position="55"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OAG12401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="489" mass="54747" checksum="13F9D5A163A2A6B7" modified="2016-09-07" version="1">MNCSVRILRPVARSRWRGASLRRPLSVSAAELRFGQPLHETHPHLLKPGEITPGITAQEYYDRRARLAKALPKGSIAVLAASDVKYRSGAVFYKFHQDPDFLYLTGFNEPDALAIIEKIDDDEHNFHLYVRPKDPKLEQWEGSRSGIQAAEDVFNADTTGDINNLPKILPEVLKRAEQVYTDLPNNRINRNLLSRYLSGAEPSRTGGIVTVFRESEKKIKPLRAYLNELRVIKSEAELKNMRKAGQHSGRAITDAMRQTWTAEKDLDAFLDYWFKQDGCDGPAYVPVVAGGINANTIHYVTNDMPLKPDELVLVDAGAEYGGYITDISRTWPVSGKFNPAQKDLYQVLLNVQRSCVSLCTVSSQLTLDRLHRIASRTLADGLTDLGFDMSNDAIEKLFPHHVGHYVGLDVHDSPGLTRGKAFEKGMCVTVEPGIYVPDDERWPAWARGIGMRIEDSVCVDDDSPYILTTEAVKEIDDIEALKGTESRLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CZU3</accession>
    <name>A0A177CZU3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">V-type proton ATPase subunit H</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CC84DRAFT_1159896</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the V-ATPase H subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042973.1">
        <property type="nucleotide sequence ID" value="XM_018177357.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CZU3"/>
    <dbReference type="FunCoup" id="A0A177CZU3">
        <property type="interactions" value="397"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CZU3"/>
    <dbReference type="GeneID" id="28760843"/>
    <dbReference type="InParanoid" id="A0A177CZU3"/>
    <dbReference type="OrthoDB" id="10263554at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000221">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase, V1 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000326">
        <property type="entry name" value="V-type proton ATPase subunit H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.150:FF:000002">
        <property type="entry name" value="V-type proton ATPase subunit H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.150">
        <property type="entry name" value="V-type ATPase, subunit H, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004908">
        <property type="entry name" value="ATPase_V1-cplx_hsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011987">
        <property type="entry name" value="ATPase_V1-cplx_hsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038497">
        <property type="entry name" value="ATPase_V1-cplx_hsu_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10698">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10698:SF0">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11698">
        <property type="entry name" value="V-ATPase_H_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03224">
        <property type="entry name" value="V-ATPase_H_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF032184">
        <property type="entry name" value="ATPase_V1_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="4 5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATPase V1 complex subunit H C-terminal" evidence="6">
        <location>
            <begin position="358"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR032184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF11698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAG12608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="484" mass="54326" checksum="DEB3EF27CDD44265" modified="2016-09-07" version="1">MSLDPPAYLVTIQANIRTRPISWEGAMRAKTITETDLQKIKSIDKVRKEDRKNRVEGDVQSFVSLLLGGNGSHSIFEAAAKRQDIVQYMLVLTEDLINDIPALTEALIQHPSPFKPFLPLLKAGSNAEDTIPLLTSSVLSKFLSYALVHSTKTTSQIDEALPQLYNYLAALAKSQDAGLQDIAVQEYSAVLRNKKSRQLFWDQRKETLNPLVDILTAASGATKDQISLRSGAAGSVRSVPEGLTGGVGLQLLYHVLLVVWQLSFEGELVGDGLQDEHDVVMLYTHLLRISPKEKTTRLLLSTLLNLLTSNRQTLLPAAVLARLPSLLSTLKSRHLTDDDALEDLKSLTELLEEYTTTQTTFDEYAAEIRSGHLRWSPPHRNPDFWRDNARRILEDNKGELPRKLAEILSKPWDNDKQVLAIGCNDVACLVKEVPEKRYQLEKLGLKGRVMALMQEADETVRWESLRAVGEWLRYSFESKDLPIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177D0A9</accession>
    <name>A0A177D0A9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">FAD/NAD(P)-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CC84DRAFT_1135837</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAD-binding monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018043183.1">
        <property type="nucleotide sequence ID" value="XM_018176076.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177D0A9"/>
    <dbReference type="GeneID" id="28759562"/>
    <dbReference type="InParanoid" id="A0A177D0A9"/>
    <dbReference type="OrthoDB" id="74360at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051209">
        <property type="entry name" value="FAD-bind_Monooxygenase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877:SF2">
        <property type="entry name" value="FAD_NAD(P)-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAG12818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="535" mass="60087" checksum="FB62D3EE04BBF4AF" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177D0G1</accession>
    <name>A0A177D0G1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CC84DRAFT_1160381</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG13174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018043539.1">
        <property type="nucleotide sequence ID" value="XM_018177483.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177D0G1"/>
    <dbReference type="STRING" id="1460663.A0A177D0G1"/>
    <dbReference type="GeneID" id="28760969"/>
    <dbReference type="InParanoid" id="A0A177D0G1"/>
    <dbReference type="OrthoDB" id="2898618at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052178">
        <property type="entry name" value="Sec_Metab_Biosynth_SDR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618">
        <property type="entry name" value="7-ALPHA-HYDROXYSTEROID DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618:SF18">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_5G12480)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAG13174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="320" mass="33208" checksum="4E7FCC2C080C461A" modified="2016-09-07" version="1">MDVQAPFNPSALFSAKGLVVVITGGGSGLGLAYASALYQNGAEKIYILGRRLNILEDAIKTLEASPSAPKNASSVLAAIACDVTDQKSVGDAVAQVQKEVGYVDVLINNAGVLGPTNGADLYKAESIDQLKDAMVQDYAGWDLAFKINTQAVIGMSAAFLPLLEAANTRRGWAKGKVEGEGNPRAQDTSVLSKIGCDADDDRMAHIITTASVASFMRYCTAGLAYNASKAGAAHLSKMLASFLAPWGIRSNVIAPGPYPSEMTKSRSAKFGTGAVPQGRMGSANDISALLLFLVGKGGAYTNGTVQVTDGGRMGVFPGTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BSZ0</accession>
    <name>A0A177BSZ0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glutathione S-transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_1132611</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GST superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV441572">
        <property type="protein sequence ID" value="OAF98493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018028859.1">
        <property type="nucleotide sequence ID" value="XM_018175939.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BSZ0"/>
    <dbReference type="STRING" id="1460663.A0A177BSZ0"/>
    <dbReference type="GeneID" id="28759425"/>
    <dbReference type="InParanoid" id="A0A177BSZ0"/>
    <dbReference type="OrthoDB" id="422574at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051:SF3">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR URE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14497">
        <property type="entry name" value="GST_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST N-terminal" evidence="2">
        <location>
            <begin position="4"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="3">
        <location>
            <begin position="91"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAF98493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="225" mass="25517" checksum="9AADA22CE64B922E" modified="2016-09-07" version="1">MSIQPIEIWGHWGAANPSKVRMVLEQLQLPYIVHLKEFTEIKNNDYLKINPNGQLPAIRDPNSGLTLWETGAIIQYLVDQYDTEGKISYKTFPEKHLTQQWLAFETSGQSPYFAEATYFVRFNPEKIPSAIDRYVNEILRVTGVLDKAIKANGTGWLVGSKMTYADLSFEAWSTIGEGLLKHLGKWEGFEQQFPTYTAWLASMRSLESVKVVEEEAARGMAAHGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BT52</accession>
    <name>A0A177BT52_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNase III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1106065</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441566">
        <property type="protein sequence ID" value="OAF98582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018028948.1">
        <property type="nucleotide sequence ID" value="XM_018175124.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BT52"/>
    <dbReference type="STRING" id="1460663.A0A177BT52"/>
    <dbReference type="GeneID" id="28758610"/>
    <dbReference type="InParanoid" id="A0A177BT52"/>
    <dbReference type="OrthoDB" id="67027at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="entry name" value="Ribonuclease III domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="RNase III domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAF98582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="524" mass="58518" checksum="58C566E10233C519" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BUU9</accession>
    <name>A0A177BUU9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">WD40 repeat-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CC84DRAFT_424204</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441564">
        <property type="protein sequence ID" value="OAF98750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029116.1">
        <property type="nucleotide sequence ID" value="XM_018186173.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BUU9"/>
    <dbReference type="STRING" id="1460663.A0A177BUU9"/>
    <dbReference type="GeneID" id="28769659"/>
    <dbReference type="InParanoid" id="A0A177BUU9"/>
    <dbReference type="OrthoDB" id="361494at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031464">
        <property type="term" value="C:Cul4A-RING E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000109">
        <property type="term" value="C:nucleotide-excision repair complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006283">
        <property type="term" value="P:transcription-coupled nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042238">
        <property type="entry name" value="Rad28/ERCC8/Ckn1/ATCSA-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46202">
        <property type="entry name" value="DNA EXCISION REPAIR PROTEIN ERCC-8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46202:SF1">
        <property type="entry name" value="DNA EXCISION REPAIR PROTEIN ERCC-8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="52"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="195"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="262"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="412"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAF98750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="453" mass="49959" checksum="5B26BA81C04BB47D" modified="2016-09-07" version="1">MNAQQIANRAYGISPTHVIKRALVAHLVYALQPSSVSFSARLPSPHEPNERHRAHIAGVNALTIDRFDGRYLLSGGADSSVALWDLEARPTVVDGDATYAPLSTMRKTAEEHKLGITQVSFYPFDSLAFLTSSYDHTVKIYSSETLMPSASFDLGSVVYSIALSPIASHLLVACATQHPTVRLVDLRSGASSHSLAGHSGAILSTAWSPTREHILASGATDGSVRFWDVRRSVSELGILDMEDSVGLLGRPASLFMRNSVQGKAHRGPVNGIVWTEDGHHLVTCGHDQRIRVWDTNTGANTLANFGPMVKNSDLAPCIPLLPPAKHLQSGKDVLFYPNEHEILGYELFDGKLFRRLRRTEQQKQMYGIRGQGQRNAKDKITSLAWRAHDVEMYSAHSDGSISVWLPRTEEDAALDEEAHEEQESKDESKKRKRGVLDEIYQDLTKRSLTFGGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BUW2</accession>
    <name>A0A177BUW2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Amino-acid transporter arg-13</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CC84DRAFT_1191549</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441563">
        <property type="protein sequence ID" value="OAF99094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029460.1">
        <property type="nucleotide sequence ID" value="XM_018181190.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BUW2"/>
    <dbReference type="FunCoup" id="A0A177BUW2">
        <property type="interactions" value="93"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177BUW2"/>
    <dbReference type="GeneID" id="28764676"/>
    <dbReference type="InParanoid" id="A0A177BUW2"/>
    <dbReference type="OrthoDB" id="2139348at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000064">
        <property type="term" value="F:L-ornithine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:L-arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990575">
        <property type="term" value="P:mitochondrial L-ornithine transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000109">
        <property type="entry name" value="Ornithine carrier protein AmcA/Ort1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050567">
        <property type="entry name" value="Mitochondrial_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624">
        <property type="entry name" value="MITOCHONDRIAL BASIC AMINO ACIDS TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624:SF31">
        <property type="entry name" value="MITOCHONDRIAL ORNITHINE TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="16"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="122"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="224"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OAF99094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="322" mass="35330" checksum="6CFDE001B9C33181" modified="2016-09-07" version="1">MVHEEPSAALDHTQGQEALKDVVCGSVAGVVGKYIEYPFDTVKVRLQSQPNRLPLKYTGPIDCFKKSLKQDGFVGIYRGISAPLVGAAVETSCLFFSYRLAGDALRTSGFYPELKGHPEKDLPYAGTLYCGMAAGAITSVFLTPIELVKCKMQVPLETPSATVARPGILSVIASIYRHQGLMGYWHGQFGTLIRETGGGAAWFGGYEGTKMLFKRASAVPDDDMPIWQRMASGSIAGMLYNFAFYPADTVKSRMQTEDVKQLTGQKSTFSAVWKAHWKQHGLKGMYRGCGITVARSIPSSAFIFTVYEELKLRWPAPRGQDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BVC6</accession>
    <name>A0A177BVC6_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Peptide hydrolase</fullName>
            <ecNumber evidence="11">3.4.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CC84DRAFT_1232672</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M28 family. M28B subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="11"/>
    <dbReference type="EMBL" id="KV441562">
        <property type="protein sequence ID" value="OAF99264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029630.1">
        <property type="nucleotide sequence ID" value="XM_018183768.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BVC6"/>
    <dbReference type="STRING" id="1460663.A0A177BVC6"/>
    <dbReference type="GeneID" id="28767254"/>
    <dbReference type="InParanoid" id="A0A177BVC6"/>
    <dbReference type="OrthoDB" id="10013407at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008235">
        <property type="term" value="F:metalloexopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04816">
        <property type="entry name" value="PA_SaNapH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045175">
        <property type="entry name" value="M28_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046450">
        <property type="entry name" value="PA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003137">
        <property type="entry name" value="PA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147">
        <property type="entry name" value="METALLOPEPTIDASE M28 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147:SF26">
        <property type="entry name" value="PEPTIDASE M28 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02225">
        <property type="entry name" value="PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52025">
        <property type="entry name" value="PA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 11" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="9 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PA" evidence="12">
        <location>
            <begin position="91"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M28" evidence="13">
        <location>
            <begin position="211"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OAF99264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="457" mass="48913" checksum="455A545C8D367554" modified="2016-09-07" version="1" fragment="single">SRLKQNLRALDEIGKQNGGNRAFGTTGFAKSSDYVLSQITSKHDKEFKTWKQYFNHTYEETRAISVTGPNGEDVDVLSLMYNNATPLPNGVTGELVAVPVDDALGSGCVEDQWAGLNVTGKLALVKRGTCSISDKLKIAKKLGALGVILFHNTNATPNAATLGAENIGLLAPVGLVSLAVGEAWLARISANETLTVTLLVDSIFEPRKSWNVFAETREGDPDNVIMLGAHLDSVQAGPGINDDGSGVTAQIEIIKALRGFRGIKNKIRLAFWGAEEPGLVGSLYYTEHLTPSEADKIRFYYNYDMIGSPVPVYGIYAGDNPGDKAGAQLLLDYLVAKGKPAYFGSFGTGSDYVGFLELGIPSSGIHTGGGDPADPCYHLACDTYDNISWEALEVNTKAAARAAAALALSVKDVPPRNTTSVNPRSENRIRAQFTTWEEVRLEAAGGHSCALKTKRTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BVI4</accession>
    <name>A0A177BVI4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_393275</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441562">
        <property type="protein sequence ID" value="OAF99324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029690.1">
        <property type="nucleotide sequence ID" value="XM_018186027.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BVI4"/>
    <dbReference type="GeneID" id="28769513"/>
    <dbReference type="InParanoid" id="A0A177BVI4"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAF99324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="77" mass="8426" checksum="92E410FC03F69F50" modified="2016-09-07" version="1">MPETSTPVLIGSHLKRTRRLLRAWTLPLPAFLFFCLPAASLLPESGAVPLSPLASPHASFWEPWSMVSAARIPHPTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BVT9</accession>
    <name>A0A177BVT9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">DNA repair protein rad5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CC84DRAFT_1191691</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441564">
        <property type="protein sequence ID" value="OAF98841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029207.1">
        <property type="nucleotide sequence ID" value="XM_018181197.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BVT9"/>
    <dbReference type="FunCoup" id="A0A177BVT9">
        <property type="interactions" value="1034"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177BVT9"/>
    <dbReference type="GeneID" id="28764683"/>
    <dbReference type="InParanoid" id="A0A177BVT9"/>
    <dbReference type="OrthoDB" id="2801544at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18008">
        <property type="entry name" value="DEXDc_SHPRH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014905">
        <property type="entry name" value="HIRAN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050628">
        <property type="entry name" value="SNF2_RAD54_helicase_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626:SF22">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08797">
        <property type="entry name" value="HIRAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24975">
        <property type="entry name" value="UBA_Rad5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00910">
        <property type="entry name" value="HIRAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="11" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0347">Helicase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="16">
        <location>
            <begin position="473"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="15">
        <location>
            <begin position="857"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="17">
        <location>
            <begin position="947"/>
            <end position="1103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="128"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="322"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="22"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="132"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="338"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="350"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="364"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="OAF98841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="20">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1113" mass="124511" checksum="CB203B4E8CB49E39" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BW81</accession>
    <name>A0A177BW81_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ankyrin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CC84DRAFT_1264224</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441562">
        <property type="protein sequence ID" value="OAF99210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029576.1">
        <property type="nucleotide sequence ID" value="XM_018185292.1"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177BW81"/>
    <dbReference type="GeneID" id="28768778"/>
    <dbReference type="InParanoid" id="A0A177BW81"/>
    <dbReference type="OrthoDB" id="21416at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051165">
        <property type="entry name" value="Multifunctional_ANK_Repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24123">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24123:SF33">
        <property type="entry name" value="PROTEIN HOS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="18"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="5">
        <location>
            <begin position="60"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="561"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="594"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="717"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="917"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1034"/>
            <end position="1068"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1229"/>
            <end position="1261"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1600"/>
            <end position="1637"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1806"/>
            <end position="1838"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1890"/>
            <end position="1923"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1477"/>
            <end position="1513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1493"/>
            <end position="1513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAF99210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="2117" mass="234586" checksum="07B2A9ABFB0CC3CD" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BW96</accession>
    <name>A0A177BW96_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1169108</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441561">
        <property type="protein sequence ID" value="OAF99574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029940.1">
        <property type="nucleotide sequence ID" value="XM_018179573.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BW96"/>
    <dbReference type="STRING" id="1460663.A0A177BW96"/>
    <dbReference type="GeneID" id="28763059"/>
    <dbReference type="InParanoid" id="A0A177BW96"/>
    <dbReference type="OrthoDB" id="28755at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37490">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37490:SF1">
        <property type="entry name" value="GLYCOSYLTRANSFERASE 2-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="206"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="245"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="278"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="309"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="378"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAF99574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="685" mass="75972" checksum="705971076550163F" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BWM1</accession>
    <name>A0A177BWM1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Nucleolar protein 12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CC84DRAFT_1169879</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRP17 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441564">
        <property type="protein sequence ID" value="OAF98719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029085.1">
        <property type="nucleotide sequence ID" value="XM_018179777.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BWM1"/>
    <dbReference type="FunCoup" id="A0A177BWM1">
        <property type="interactions" value="209"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177BWM1"/>
    <dbReference type="GeneID" id="28763263"/>
    <dbReference type="InParanoid" id="A0A177BWM1"/>
    <dbReference type="OrthoDB" id="551633at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019186">
        <property type="entry name" value="Nucleolar_protein_12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14577">
        <property type="entry name" value="NUCLEOLAR PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14577:SF0">
        <property type="entry name" value="NUCLEOLAR PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09805">
        <property type="entry name" value="Nop25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="81"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="143"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="88"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="143"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="171"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAF98719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="210" mass="24491" checksum="904A3029B129A691" modified="2016-09-07" version="1">MAPPSKKRKIAAIPEISFDPAAREEYLTGFHKRKLARQKLAEEENAKKERAEKLRFRAEVRKQRKEDLEKHVEEVNRLVRQANGDLSEAGEEDEDSTNEEWNGIVEPPAPIPSAMDINEEEEFIDEDKYTTVTIESVGISKHGFERRGGKEEAEEVESKEKRVWTKERPKSNKPKKKKIKFRYETKTERKVERVKQGLKKKKMAAKRMGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BX01</accession>
    <name>A0A177BX01_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosome-releasing factor 2, mitochondrial</fullName>
            <shortName evidence="6">RRF2mt</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Elongation factor G 2, mitochondrial</fullName>
            <shortName evidence="6">EF-G2mt</shortName>
            <shortName evidence="6">mEF-G 2</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">MEF2</name>
        <name evidence="8" type="ORF">CC84DRAFT_1130983</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.</text>
    </comment>
    <comment type="function">
        <text evidence="6">Mitochondrial GTPase that mediates the disassembly of ribosomes from messenger RNA at the termination of mitochondrial protein biosynthesis. Not involved in the GTP-dependent ribosomal translocation step during translation elongation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV441562">
        <property type="protein sequence ID" value="OAF99221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029587.1">
        <property type="nucleotide sequence ID" value="XM_018175878.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BX01"/>
    <dbReference type="FunCoup" id="A0A177BX01">
        <property type="interactions" value="584"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177BX01"/>
    <dbReference type="GeneID" id="28759364"/>
    <dbReference type="InParanoid" id="A0A177BX01"/>
    <dbReference type="OrthoDB" id="198619at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051881">
        <property type="term" value="P:regulation of mitochondrial membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032790">
        <property type="term" value="P:ribosome disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01886">
        <property type="entry name" value="EF-G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16262">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03713">
        <property type="entry name" value="EFG_mtEFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000106">
        <property type="entry name" value="Ribosome-releasing factor 2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.870:FF:000007">
        <property type="entry name" value="Ribosome-releasing factor 2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000514">
        <property type="entry name" value="Ribosome-releasing factor 2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.870">
        <property type="entry name" value="Elongation Factor G (Translational Gtpase), domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03059">
        <property type="entry name" value="mEF_G_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053905">
        <property type="entry name" value="EF-G-like_DII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030851">
        <property type="entry name" value="EFG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041095">
        <property type="entry name" value="EFG_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009022">
        <property type="entry name" value="EFG_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035649">
        <property type="entry name" value="EFG_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43261:SF1">
        <property type="entry name" value="RIBOSOME-RELEASING FACTOR 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43261">
        <property type="entry name" value="TRANSLATION ELONGATION FACTOR G-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22042">
        <property type="entry name" value="EF-G_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14492">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="EF-G C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="1 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="7">
        <location>
            <begin position="37"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="46"/>
            <end position="53"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="133"/>
            <end position="137"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="187"/>
            <end position="190"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAF99221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="883" mass="95599" checksum="B46FD2FFFE7D7130" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BX14</accession>
    <name>A0A177BX14_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PWWP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1264491</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441563">
        <property type="protein sequence ID" value="OAF98916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029282.1">
        <property type="nucleotide sequence ID" value="XM_018185313.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BX14"/>
    <dbReference type="STRING" id="1460663.A0A177BX14"/>
    <dbReference type="GeneID" id="28768799"/>
    <dbReference type="InParanoid" id="A0A177BX14"/>
    <dbReference type="OrthoDB" id="62853at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000313">
        <property type="entry name" value="PWWP_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00855">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00293">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50812">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PWWP" evidence="2">
        <location>
            <begin position="139"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="284"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="476"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="54"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="75"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="299"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="318"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="341"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="354"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="495"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAF98916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="564" mass="60892" checksum="BFDEE7BE531EC640" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BX83</accession>
    <name>A0A177BX83_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1263824</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441560">
        <property type="protein sequence ID" value="OAG00114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030479.1">
        <property type="nucleotide sequence ID" value="XM_018185261.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BX83"/>
    <dbReference type="GeneID" id="28768747"/>
    <dbReference type="InParanoid" id="A0A177BX83"/>
    <dbReference type="OrthoDB" id="3793746at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.30">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036361">
        <property type="entry name" value="SAP_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68906">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="272"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="46"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="233"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG00114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="322" mass="34457" checksum="B958C5A38679DDA1" modified="2016-09-07" version="1">MSDYKKRKSHELAELLVRRGLDASGTKTQMMSRLVMQDQEQISADRALAAAIQAASHNPPPQKHGNENEQSQGEWSKVKSTSADRGGAQKDSEMMRKARLEKGGQSVKSKGKEVGGGGYFGVLGEGSKDVEGTGEVDEEAFVKSLMAGGAMGGCKAIYDSQHNSGIVVNPTTAVPTMRGGAGRARTQRNTSSTRPVDDDDSLSDASTVRPLSVVAPERIPLPQDNDDQEKSGKSGRKRKAKSGKTGGLTNEAAFHALHGRPVRRAASNGSRVSMKVFFWALFIAMAYISWLKPGTMTEVLGYLVAFVKDPLGSVYQSITGPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BXJ2</accession>
    <name>A0A177BXJ2_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1222847</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441561">
        <property type="protein sequence ID" value="OAF99845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030211.1">
        <property type="nucleotide sequence ID" value="XM_018183429.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BXJ2"/>
    <dbReference type="GeneID" id="28766915"/>
    <dbReference type="InParanoid" id="A0A177BXJ2"/>
    <dbReference type="OrthoDB" id="3650679at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAF99845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="274" mass="31381" checksum="048B907F6E6CBFB2" modified="2016-09-07" version="1">MACLTSPAELRNKVYDLVATAPVASINHRTGRTDGSYAALTRVCRQIRCEFLPIQRREAKVCLPLEQLGEWIRTATSHPDKAPKLMRLVPDFGKFYYSEIHHVYDVLPLLRLNHRLNSSTVFEIAGAAQGDEWKTPQKLSQTDPTHWESLGIEMRWSIYRRERSRRWFATAVTAMEKLLHHSDPAWVALVKSRYVTRADFNMDIGLLTVTMSDEILHEDDHPDWRSTLDPTAGGMEDMLSCIHVYFLRANGERSLEAIWRTSSVGGSPWSVVWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BZP0</accession>
    <name>A0A177BZP0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1222114</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441559">
        <property type="protein sequence ID" value="OAG00626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030991.1">
        <property type="nucleotide sequence ID" value="XM_018183334.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BZP0"/>
    <dbReference type="GeneID" id="28766820"/>
    <dbReference type="InParanoid" id="A0A177BZP0"/>
    <dbReference type="OrthoDB" id="2851338at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG00626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="262" mass="29989" checksum="F8F6AF025B292DDC" modified="2016-09-07" version="1">MAPGLFCVWSQADPDTSAEVNTEDKTFSDVVTKLPGVSLGTQVKLMKRQVNEYPFSHEIPFMTMYDMPDVEYRNDEAFKEAAKACESRGDNACKPRVYEEFYRREVAGCEEIHPRLGDNISIVTCEAPPPESKEGFWKWQKETFTPSFLDGPTFLRARILKEVGGETRTESVMPSAPYLWIFEWEDDELPWIELTGAAQSAEWVKYIENGLIFQGMCYYAKRYTERFEMTLSPGNTDYENDGTSSIDSRSIISFDGDETIDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C0G7</accession>
    <name>A0A177C0G7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">TrkH-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CC84DRAFT_1190484</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441559">
        <property type="protein sequence ID" value="OAG00389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030754.1">
        <property type="nucleotide sequence ID" value="XM_018181120.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C0G7"/>
    <dbReference type="STRING" id="1460663.A0A177C0G7"/>
    <dbReference type="GeneID" id="28764606"/>
    <dbReference type="InParanoid" id="A0A177C0G7"/>
    <dbReference type="OrthoDB" id="9999863at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140107">
        <property type="term" value="F:high-affinity potassium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030007">
        <property type="term" value="P:intracellular potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990573">
        <property type="term" value="P:potassium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003445">
        <property type="entry name" value="Cat_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051143">
        <property type="entry name" value="TrkH_K-transport"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31064:SF30">
        <property type="entry name" value="HIGH-AFFINITY POTASSIUM TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31064">
        <property type="entry name" value="POTASSIUM TRANSPORT PROTEIN DDB_G0292412-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02386">
        <property type="entry name" value="TrkH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="110"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="286"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="361"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="409"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="462"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="161"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="616"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="181"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="199"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="617"/>
            <end position="628"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAG00389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="656" mass="74132" checksum="6BBDA1FD35806D17" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C0S3</accession>
    <name>A0A177C0S3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Proteasome subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CC84DRAFT_1168542</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Non-catalytic component of the proteasome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase T1B family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441559">
        <property type="protein sequence ID" value="OAG00442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030807.1">
        <property type="nucleotide sequence ID" value="XM_018179425.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C0S3"/>
    <dbReference type="FunCoup" id="A0A177C0S3">
        <property type="interactions" value="1187"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177C0S3"/>
    <dbReference type="GeneID" id="28762911"/>
    <dbReference type="InParanoid" id="A0A177C0S3"/>
    <dbReference type="OrthoDB" id="10248542at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019774">
        <property type="term" value="C:proteasome core complex, beta-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034515">
        <property type="term" value="C:proteasome storage granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010499">
        <property type="term" value="P:proteasomal ubiquitin-independent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043248">
        <property type="term" value="P:proteasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd03760">
        <property type="entry name" value="proteasome_beta_type_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000014">
        <property type="entry name" value="Proteasome subunit beta type-7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016295">
        <property type="entry name" value="Proteasome_beta4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF6">
        <property type="entry name" value="PROTEASOME SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001213">
        <property type="entry name" value="Psome_endopept_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 4 5" id="KW-0647">Proteasome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR001213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAG00442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="261" mass="29062" checksum="EAB93CCE1CD16792" modified="2016-09-07" version="1">MNHLPQAWGRPRDDVYGAYDHSHFQTAAGPNQHTQQPIVTGTSVVAAKFKDGVVIAADNLASYGSLARFTDVKRLRKFNETVVVGFGGDVSDMQYLDRLLNSLDIRENYASSDDPLNAKNLHTYLAKVMYKRRSDFNPLWNHLLIAGLDGESKPFLASADLLGTTFSSPTLATGFGAHLAQPIMRRTIPDEASVENVTKEDAVKLVKECMKVLFYRDARSMDKYSIATITKEGVELHEDEKLENQSWAFAEQIRGYGTQTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C0W3</accession>
    <name>A0A177C0W3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_194756</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441557">
        <property type="protein sequence ID" value="OAG01434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031799.1">
        <property type="nucleotide sequence ID" value="XM_018185550.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C0W3"/>
    <dbReference type="STRING" id="1460663.A0A177C0W3"/>
    <dbReference type="GeneID" id="28769036"/>
    <dbReference type="InParanoid" id="A0A177C0W3"/>
    <dbReference type="OrthoDB" id="5317787at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="205"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="417"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="222"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="417"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG01434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="439" mass="50190" checksum="C63C270D2EA29F51" modified="2016-09-07" version="1">MARTCETSRSHSSRSTTISSRRSDDTAPTEYSARPAVPRTGTCLGRVEGHSRDYFATEGTIDGRTSVDTYASTSEEDLADDFDHVPEYHVPEYTHTPLPVDAIPTTPRDFADLFPTSKRISIRHDDSTIDGNMNLRVDTQVEEHNRNKQNYTLFHLRMHDLRTREFSLRRYCRDSGREVCHSIRKYQKPPSEKRPVLQRASTALASFRHKPDSRPSTAGGLKRSDSGYESVHDVEVDEHESLPQPTGYAKGRALLPTNTLKLEFSNYAHIDVKRRGAHSGKKYAFEYWGYNYSWKRVVKQENSHESVSYYLIRSDNESEPLAHISPVRLTHEQAREEAARGGWIPPCYMRITDEHILKSNSDISDVVVATGLMALVDDCIKRRFHQKQSTQLHIPLIRNKLHLDYIGPKRLIDEMFNRTSRSGPPSRQPSALRRPATQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C1F9</accession>
    <name>A0A177C1F9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1129363</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441559">
        <property type="protein sequence ID" value="OAG00557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030922.1">
        <property type="nucleotide sequence ID" value="XM_018175830.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C1F9"/>
    <dbReference type="GeneID" id="28759316"/>
    <dbReference type="InParanoid" id="A0A177C1F9"/>
    <dbReference type="OrthoDB" id="3365399at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd17080">
        <property type="entry name" value="Ubl_SLD2_Esc2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022617">
        <property type="entry name" value="Rad60/SUMO-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10562">
        <property type="entry name" value="SMALL UBIQUITIN-RELATED MODIFIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11976">
        <property type="entry name" value="Rad60-SLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="2">
        <location>
            <begin position="364"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="209"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG00557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="436" mass="48723" checksum="918CED56E244C66F" modified="2016-09-07" version="1">MTDPTDGAAAPPKRRAFGFKKAAWQTAPKKDEQDMFSHSNEFQDIVAEQAKRQEEKKKAEEAQKQRQKAEEERHRKRRKVSVESDEGVQARSSSRNHRVTSKGRSKTPMSPTRNNSTSETLAARYDSLTKSSSSSVGARTRSQVIDLGDTEDEDEYPRNPSPSPRAIPIHSRPQSERESSEEVEEVDSPHIAVLKAQIRAKASAKSPDADQAPTASSSAQAPMPVAIVQLLIESDIPDTKPLMVKIKTDASLAKPKEAWCTRQGFTPAQTRAIFMTWKGRRIFDYTKIQRLGIRLENGYVSVEGDPNIYDDENLPRIHVAAWTEEVYKARKEADALEAAAAAQAAKVVNEPEPEAEPEPEVKQIKLVLKAKGREDFKLKVNPHTEVSHMASAYKMAMKIPKEQPVTLMFDGDRLKPMDTVADIDVDDMDAIEVHFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C1H2</accession>
    <name>A0A177C1H2_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SIMPL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1167810</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441557">
        <property type="protein sequence ID" value="OAG01634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031999.1">
        <property type="nucleotide sequence ID" value="XM_018179268.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C1H2"/>
    <dbReference type="GeneID" id="28762754"/>
    <dbReference type="InParanoid" id="A0A177C1H2"/>
    <dbReference type="OrthoDB" id="3335918at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007497">
        <property type="entry name" value="SIMPL/DUF541"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04402">
        <property type="entry name" value="SIMPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG01634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="240" mass="26460" checksum="F49131A71EC2FCB8" modified="2016-09-07" version="1">MAPFDIHVAGTGTNRHPAERSILTLHTQTKCFPTIPEAETSVVSIINSLLDAIAPYCHQTATTGSTKAEDNAPISHYSLKSFETSQGRDTSMSFSKSSSHKSTYASADLIIEFRDFALLARLATTIGAMENVKINCLEWILTPATRATMEAQARKEAAKHAIRKARDYAEVFGGLTEEEAQSKVRAVLVKESFQYTKFTKPKLHLGKANGGRMQKSEWDYEPQDVGVEVKVDGTFTVEIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C1R2</accession>
    <name>A0A177C1R2_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Presequence translocated-associated motor subunit PAM17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CC84DRAFT_321223</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Component of the PAM complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Mitochondrion inner membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the PAM17 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441559">
        <property type="protein sequence ID" value="OAG00667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031032.1">
        <property type="nucleotide sequence ID" value="XM_018185846.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C1R2"/>
    <dbReference type="FunCoup" id="A0A177C1R2">
        <property type="interactions" value="51"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177C1R2"/>
    <dbReference type="GeneID" id="28769332"/>
    <dbReference type="InParanoid" id="A0A177C1R2"/>
    <dbReference type="OrthoDB" id="5970083at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001405">
        <property type="term" value="C:PAM complex, Tim23 associated import motor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013875">
        <property type="entry name" value="Pam17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28021">
        <property type="entry name" value="PRESEQUENCE TRANSLOCATED-ASSOCIATED MOTOR SUBUNIT PAM17, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28021:SF1">
        <property type="entry name" value="PRESEQUENCE TRANSLOCATED-ASSOCIATED MOTOR SUBUNIT PAM17, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08566">
        <property type="entry name" value="Pam17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 12" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="6 12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="9 12" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="102"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="136"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU367146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OAG00667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="234" mass="25467" checksum="8DB8F555A05FC0B2" modified="2016-09-07" version="1">MFAPSALRQARTFTIRLQPGFIAPCASATAAPFSTKTSTRPAQQQCTQRSSFRPSPLALAIRHATTAASSASAANATSSSSQQLTWNDFFALRKTRRRASQVTSGISAIGVAYVGLQVFIGGGYDGLLAASIGLDPIITTGLASAAMLTVGWLVGPFFSNAVFNVRNRAIAPQITKKEREFYDRIKKHRVDPTSSSMANPVPDYYGEKIGSVADYRRWLKDQRAFNLKRGERRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C208</accession>
    <name>A0A177C208_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Solute carrier family 40 member</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_1128101</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">May be involved in iron transport and iron homeostasis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the ferroportin (FP) (TC 2.A.100) family. SLC40A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KV441558">
        <property type="protein sequence ID" value="OAG00882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031247.1">
        <property type="nucleotide sequence ID" value="XM_018175786.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C208"/>
    <dbReference type="STRING" id="1460663.A0A177C208"/>
    <dbReference type="GeneID" id="28759272"/>
    <dbReference type="InParanoid" id="A0A177C208"/>
    <dbReference type="OrthoDB" id="648861at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005381">
        <property type="term" value="F:iron ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd17480">
        <property type="entry name" value="MFS_SLC40A1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009716">
        <property type="entry name" value="Ferroportin-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11660">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 40 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11660:SF57">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 40 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06963">
        <property type="entry name" value="FPN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="54"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="271"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="313"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="345"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="438"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAG00882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="499" mass="54611" checksum="B2A8C4DC75D8E4A9" modified="2016-09-07" version="1">MPSTSEAVNNGHAPDLSPVESFSSSTNRFSTRAVLWKLYLSHTLSTWNARTFEFSAVIFLGSIFPNTLFYASCYALFRSLTAFLLSPTVGHQVDSRERLGVVRHSIIWQRVSVAGSCGILLLLLRSAPETWTKVAWFSICVVLAGVEKLAFVGNTVAVERDWVVVVAEGLGVPREDLNSKMRRIDLVCKLVAPFGISLVDGYSTEVAIWAVLGQNTLSIVFEYFAIAQVYHAVPGLASRKSSTAPINIEGRDMATPNSRGLSAAIQQWIDYFMNPACLASFSLALLYFTVLGFGSQLTTYLLTLGFTSTHIAGMRLISVILELSATCAAPLLMRRIGAVRAGLWFINYQLITVILAISLFTLSTPSTQTAGLALVAGVALSRLGLWGFDLCVQYLVQEDAPEATRGSFSSIEASLQNLFELCSFATTMVWARPDQFRFPVWVSGGVLAVSAACFAAFVRGKRGHLLHSSRCLEKRSGRYKVLPTIEEESELEPENVRQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C2W3</accession>
    <name>A0A177C2W3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Short-chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_1263053</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441558">
        <property type="protein sequence ID" value="OAG00990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031355.1">
        <property type="nucleotide sequence ID" value="XM_018185204.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C2W3"/>
    <dbReference type="STRING" id="1460663.A0A177C2W3"/>
    <dbReference type="GeneID" id="28768690"/>
    <dbReference type="InParanoid" id="A0A177C2W3"/>
    <dbReference type="OrthoDB" id="2898618at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052178">
        <property type="entry name" value="Sec_Metab_Biosynth_SDR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618">
        <property type="entry name" value="7-ALPHA-HYDROXYSTEROID DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618:SF18">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_5G12480)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAG00990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="302" mass="32311" checksum="AF940C7738D2B1E2" modified="2016-09-07" version="1">MASTSAFDSSTLFRVDGIVAVITGGGSGIGLMMTRALAFNGAKKVYIIGRRLEKLEEAAKEHESIIPIQGDVTSKQDLQGAVDRITSEVGYVNLIIANSGDIGPPVRYNPDDSIKELREKLFTNFKPEDMTNTLNLNVTAAFFTMTAFIELLDAGNKQALSGGFGKPAEGSKVPLIQSQVIFTSSISAFSRHSSSSVPYAASKVAIMQIAKHSSSQLSRYGIRVNALAPGLFPSELASVLINTRKPEEESPSDPRFTPSRRFGTDEEMAGAILYLASRAGAFTNGTVFTLDGGRLSVIPSTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C313</accession>
    <name>A0A177C313_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1221262</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441557">
        <property type="protein sequence ID" value="OAG01786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032151.1">
        <property type="nucleotide sequence ID" value="XM_018183249.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C313"/>
    <dbReference type="STRING" id="1460663.A0A177C313"/>
    <dbReference type="GeneID" id="28766735"/>
    <dbReference type="InParanoid" id="A0A177C313"/>
    <dbReference type="OrthoDB" id="10254945at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG01786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="540" mass="62240" checksum="DDEFE1AA80A0E967" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C335</accession>
    <name>A0A177C335_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Molybdopterin synthase sulfur carrier subunit</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Common component for nitrate reductase and xanthine dehydrogenase protein G</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Molybdenum cofactor synthesis protein 2 small subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Molybdenum cofactor synthesis protein 2A</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Sulfur carrier protein MOCS2A</fullName>
            <shortName evidence="5">MOCS2A</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">cnxG</name>
        <name evidence="6" type="ORF">CC84DRAFT_1167275</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Acts as a sulfur carrier required for molybdopterin biosynthesis. Component of the molybdopterin synthase complex that catalyzes the conversion of precursor Z into molybdopterin by mediating the incorporation of 2 sulfur atoms into precursor Z to generate a dithiolene group. In the complex, serves as sulfur donor by being thiocarboxylated (-COSH) at its C-terminus by UBA4. After interaction with MOCS2B, the sulfur is then transferred to precursor Z to form molybdopterin.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Heterotetramer; composed of 2 small (MOCS2A) and 2 large (MOCS2B) subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="5">C-terminal thiocarboxylation occurs in 2 steps, it is first acyl-adenylated (-COAMP) via the hesA/moeB/thiF part of UBA4, then thiocarboxylated (-COSH) via the rhodanese domain of UBA4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the MoaD family. MOCS2A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV441556">
        <property type="protein sequence ID" value="OAG02154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032519.1">
        <property type="nucleotide sequence ID" value="XM_018179143.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C335"/>
    <dbReference type="STRING" id="1460663.A0A177C335"/>
    <dbReference type="GeneID" id="28762629"/>
    <dbReference type="InParanoid" id="A0A177C335"/>
    <dbReference type="OrthoDB" id="5595860at2759"/>
    <dbReference type="UniPathway" id="UPA00344"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990133">
        <property type="term" value="C:molybdopterin adenylyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990140">
        <property type="term" value="C:molybdopterin synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030366">
        <property type="term" value="F:molybdopterin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00754">
        <property type="entry name" value="Ubl_MoaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03051">
        <property type="entry name" value="MOCS2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044672">
        <property type="entry name" value="MOCS2A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028887">
        <property type="entry name" value="MOCS2A_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016155">
        <property type="entry name" value="Mopterin_synth/thiamin_S_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003749">
        <property type="entry name" value="ThiS/MoaD-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33359">
        <property type="entry name" value="MOLYBDOPTERIN SYNTHASE SULFUR CARRIER SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33359:SF1">
        <property type="entry name" value="MOLYBDOPTERIN SYNTHASE SULFUR CARRIER SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02597">
        <property type="entry name" value="ThiS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54285">
        <property type="entry name" value="MoaD/ThiS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="1-thioglycine; alternate" evidence="5">
        <location>
            <position position="96"/>
        </location>
    </feature>
    <feature type="modified residue" description="Glycyl adenylate; alternate" evidence="5">
        <location>
            <position position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAG02154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="96" mass="10221" checksum="906A95FDE063AA77" modified="2016-09-07" version="1">MASPKAPAGHFSILYFASASTFTNKTSEYLSAPVEARGLFSKLEELYPGINDKVLNSCAVTVNLSYIEIDGDEAPDLKIVIKEGDEVAIIPPVSSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C356</accession>
    <name>A0A177C356_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_202349</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441557">
        <property type="protein sequence ID" value="OAG01601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031966.1">
        <property type="nucleotide sequence ID" value="XM_018185579.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C356"/>
    <dbReference type="STRING" id="1460663.A0A177C356"/>
    <dbReference type="GeneID" id="28769065"/>
    <dbReference type="InParanoid" id="A0A177C356"/>
    <dbReference type="OrthoDB" id="1263307at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052897">
        <property type="entry name" value="Sec-Metab_Biosynth_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37017">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37017:SF11">
        <property type="entry name" value="ESTERASE_LIPASE_THIOESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="6"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG01601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="251" mass="27337" checksum="F094520467574333" modified="2016-09-07" version="1">MSQPQIVLFPGAWHLPTCYSLIIPKLEAAGYTVHTTQLPSVTDKDPPKDLSADIAVARAIVDKAIGSGNDVIVVCHSWSGIVVGSALVGYSKKEREEKGKEGGVVRCGYMCAFLAPEGLSLTESIQGPPPTWWTIEGEHFARLTDSAGDILYNDLPDSHRAQWFEKVSRTHSVHSFVAKATGESWKQIPTYYLICEDDLAIPVAGQEAMTAMVKNMGGELRTERLKSSHSPFLSHVDETVSWIRGVAGEDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C3P5</accession>
    <name>A0A177C3P5_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FAD/NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_1167176</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the flavin-dependent halogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441556">
        <property type="protein sequence ID" value="OAG02026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032391.1">
        <property type="nucleotide sequence ID" value="XM_018179132.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C3P5"/>
    <dbReference type="STRING" id="1460663.A0A177C3P5"/>
    <dbReference type="GeneID" id="28762618"/>
    <dbReference type="InParanoid" id="A0A177C3P5"/>
    <dbReference type="OrthoDB" id="5278911at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050816">
        <property type="entry name" value="Flavin-dep_Halogenase_NPB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43747:SF5">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43747">
        <property type="entry name" value="FAD-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="282"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="283"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAG02026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="764" mass="84962" checksum="B397E588D39A84D8" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C3S6</accession>
    <name>A0A177C3S6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1208178</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441556">
        <property type="protein sequence ID" value="OAG02056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032421.1">
        <property type="nucleotide sequence ID" value="XM_018182149.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C3S6"/>
    <dbReference type="STRING" id="1460663.A0A177C3S6"/>
    <dbReference type="GeneID" id="28765635"/>
    <dbReference type="InParanoid" id="A0A177C3S6"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF8">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="2">
        <location>
            <begin position="91"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG02056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="329" mass="36091" checksum="A908FDF3DD78A7B9" modified="2016-09-07" version="1">MASEGFAKPWVEASRAMQPFEEEFGERPLLPYDSIEECLEGFGKIGAKMASRYTFPAPDPAVQTEDKTIDGGLKVRIYTPEGYSGRRPVGVYYHGGGWAMGDMDGDDAFCRSISKGGNVVLVSVEYGLAPQNKHPGLINDCFAGLQWTLKNAKVLGGVEGKIFTAGVSAGGQLAIALALKALDEGLGDSLVGVVAQVPATIHPDGIPEELKARYTSYQEHANDTIDTDRAMRAFWNAFGTPPADPYGSPLLHPKIKDLKKVYLTVAGHDTLRDDGLLFKEKLEENKVPYKLDFYEGYPHYHWTWPSSKLDKPREEHNANLAKGVQWVVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C3Z0</accession>
    <name>A0A177C3Z0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Di-copper centre-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CC84DRAFT_202399</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441557">
        <property type="protein sequence ID" value="OAG01602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031967.1">
        <property type="nucleotide sequence ID" value="XM_018185580.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C3Z0"/>
    <dbReference type="STRING" id="1460663.A0A177C3Z0"/>
    <dbReference type="GeneID" id="28769066"/>
    <dbReference type="InParanoid" id="A0A177C3Z0"/>
    <dbReference type="OrthoDB" id="6132182at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1280.10">
        <property type="entry name" value="Di-copper center containing domain from catechol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008922">
        <property type="entry name" value="Di-copper_centre_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050316">
        <property type="entry name" value="Tyrosinase/Hemocyanin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002227">
        <property type="entry name" value="Tyrosinase_Cu-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474">
        <property type="entry name" value="TYROSINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474:SF126">
        <property type="entry name" value="TYROSINASE-LIKE PROTEIN TYR-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00264">
        <property type="entry name" value="Tyrosinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00092">
        <property type="entry name" value="TYROSINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48056">
        <property type="entry name" value="Di-copper centre-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00497">
        <property type="entry name" value="TYROSINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00498">
        <property type="entry name" value="TYROSINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0186">Copper</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosinase copper-binding" evidence="3">
        <location>
            <begin position="31"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosinase copper-binding" evidence="4">
        <location>
            <begin position="177"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAG01602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="338" mass="35659" checksum="D65C739A9EC4F146" modified="2016-09-07" version="1">MKLPAKLGLKGPRTRFDEFQKLHVLATETVHFVGAFLPFHRYLMHAHEHILRTDCNYTGAQPYWDEPLDAGNFSSSVVLDPVAGFGGNGTGPKNCITDGPFMDYVNAIGPFQQVSDHCIDRKIDECASAQAAAKNVDQCMASGNYSTFWPCLENAPHGAGHGGVGGQMTNLYSSPGDPLFYLHHTYLDKLWWEWQNLNLSARLTDISGTNKGILGGFPGFPGFPGNGSFPGFPGNGSFPGLPGNGSFPGFPGNGTIPGFPGNGTGPGFGGCPGFPGLPFPPQTSSAAGVTSSDFAKSDGDPGDVTTLGHVLTSFGMLPNATIADVMDTQGGLLCYEYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C473</accession>
    <name>A0A177C473_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CC84DRAFT_1020870</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441556">
        <property type="protein sequence ID" value="OAG02433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032798.1">
        <property type="nucleotide sequence ID" value="XM_018173380.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C473"/>
    <dbReference type="STRING" id="1460663.A0A177C473"/>
    <dbReference type="GeneID" id="28756866"/>
    <dbReference type="InParanoid" id="A0A177C473"/>
    <dbReference type="OrthoDB" id="9411774at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000190">
        <property type="entry name" value="C2H2 finger domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051059">
        <property type="entry name" value="VerF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626:SF8">
        <property type="entry name" value="C2H2 FINGER DOMAIN TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626">
        <property type="entry name" value="MIP31509P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="355"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="28"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="56"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="81"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="197"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="211"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OAG02433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="820" mass="91855" checksum="130C570B58B5732C" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C4K4</accession>
    <name>A0A177C4K4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1009733</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441556">
        <property type="protein sequence ID" value="OAG02346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032711.1">
        <property type="nucleotide sequence ID" value="XM_018173359.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C4K4"/>
    <dbReference type="GeneID" id="28756845"/>
    <dbReference type="InParanoid" id="A0A177C4K4"/>
    <dbReference type="OrthoDB" id="3913322at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045469">
        <property type="entry name" value="Nis1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19271">
        <property type="entry name" value="Nis1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG02346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="192" mass="20393" checksum="E19E245B407F4CF7" modified="2016-09-07" version="1">MHNSNAIKRRIHATICFQTKHATPNQTEPPTAIVETTRTLPRPLISVNMRTTALLTTALSAALTTARLTGLAAPSTLAPSSPFNLTLITENYIQSVADVSIAWGFSLAPGYPLTLGSFTSSSYLGPDKSNQLENVTIAATAPAELEEWKGKEVVLAGSLFSLYGASGSPSLTNFNVTILVGDETSEELIRSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C4N3</accession>
    <name>A0A177C4N3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Plasma membrane ATPase</fullName>
            <ecNumber evidence="10">7.1.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CC84DRAFT_1221302</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The plasma membrane ATPase of plants and fungi is a hydrogen ion pump. The proton gradient it generates drives the active transport of nutrients by H(+)-symport. The resulting external acidification and/or internal alkinization may mediate growth responses.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O + H(+)(in) = ADP + phosphate + 2 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:20852"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.1.2.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cell membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIIA subfamily.</text>
    </comment>
    <dbReference type="EC" id="7.1.2.1" evidence="10"/>
    <dbReference type="EMBL" id="KV441557">
        <property type="protein sequence ID" value="OAG01839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032204.1">
        <property type="nucleotide sequence ID" value="XM_018183257.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C4N3"/>
    <dbReference type="STRING" id="1460663.A0A177C4N3"/>
    <dbReference type="GeneID" id="28766743"/>
    <dbReference type="InParanoid" id="A0A177C4N3"/>
    <dbReference type="OrthoDB" id="116380at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008553">
        <property type="term" value="F:P-type proton-exporting transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120029">
        <property type="term" value="P:proton export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000005">
        <property type="entry name" value="Plasma membrane ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000008">
        <property type="entry name" value="Plasma membrane ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006534">
        <property type="entry name" value="P-type_ATPase_IIIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01647">
        <property type="entry name" value="ATPase-IIIA_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42861">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00120">
        <property type="entry name" value="HATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="148"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="337"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="381"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="744"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="771"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="807"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="837"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="873"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="913"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="12">
        <location>
            <begin position="77"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="244"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="244"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OAG01839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="998" mass="109891" checksum="3FD12CB3C2618E5B" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C4Q5</accession>
    <name>A0A177C4Q5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">FYVE-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_1252530</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441556">
        <property type="protein sequence ID" value="OAG02151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032516.1">
        <property type="nucleotide sequence ID" value="XM_018184359.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C4Q5"/>
    <dbReference type="FunCoup" id="A0A177C4Q5">
        <property type="interactions" value="14"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177C4Q5"/>
    <dbReference type="GeneID" id="28767845"/>
    <dbReference type="InParanoid" id="A0A177C4Q5"/>
    <dbReference type="OrthoDB" id="660555at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16489">
        <property type="entry name" value="mRING-CH-C4HC2H_ZNRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23164">
        <property type="entry name" value="EARLY ENDOSOME ANTIGEN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23164:SF30">
        <property type="entry name" value="EARLY ENDOSOME ANTIGEN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FYVE-type" evidence="7">
        <location>
            <begin position="196"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="550"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="67"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="291"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="483"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="79"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="114"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="163"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="291"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="331"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="350"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="398"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="431"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="495"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="508"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAG02151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="596" mass="64844" checksum="B1AB933DA9920ECF" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C5B6</accession>
    <name>A0A177C5B6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RmlC-like cupin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1219663</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG02705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033070.1">
        <property type="nucleotide sequence ID" value="XM_018183097.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C5B6"/>
    <dbReference type="STRING" id="1460663.A0A177C5B6"/>
    <dbReference type="GeneID" id="28766583"/>
    <dbReference type="InParanoid" id="A0A177C5B6"/>
    <dbReference type="OrthoDB" id="2096797at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02233">
        <property type="entry name" value="cupin_HNL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047263">
        <property type="entry name" value="HNL-like_cupin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43698:SF1">
        <property type="entry name" value="BLL4564 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43698">
        <property type="entry name" value="RIBD C-TERMINAL DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin type-2" evidence="2">
        <location>
            <begin position="50"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG02705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="134" mass="14351" checksum="7FC38D61FB3550F6" modified="2016-09-07" version="1">MPSTIFPAHQPSKPAQRAGPTFTGTVYSDVIHRDATVSLANVTFTPCSRTFWHTHEDGQMIKVLSGSGLVCDAGGAPRRIQAGDVVWAAPGTTHWHGADEASVMTHFVVTRGKTVWGEEVVGDGWPRVEGAERG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C5H5</accession>
    <name>A0A177C5H5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF1909-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1125106</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG03004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033369.1">
        <property type="nucleotide sequence ID" value="XM_018175710.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C5H5"/>
    <dbReference type="GeneID" id="28759196"/>
    <dbReference type="InParanoid" id="A0A177C5H5"/>
    <dbReference type="OrthoDB" id="370932at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1050.10">
        <property type="entry name" value="At2g23090-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039713">
        <property type="entry name" value="At2g23090-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039438">
        <property type="entry name" value="At2g23090-like_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026939">
        <property type="entry name" value="ZNF706/At2g23090_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33788">
        <property type="entry name" value="OS07G0114300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33788:SF1">
        <property type="entry name" value="ZINC-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12907">
        <property type="entry name" value="zf-met2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118359">
        <property type="entry name" value="Expressed protein At2g23090/F21P24.15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="At2g23090-like zinc-binding" evidence="2">
        <location>
            <begin position="36"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG03004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="78" mass="8561" checksum="D655D0D873DEEAA7" modified="2016-09-07" version="1">MGNGAKAQQKRDRAADKGPKEAKSQLKSNASAQSVKCKTCFQTFQSTTARKLLTEHASNKHSKNFEDCFNAEDGVVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C5I1</accession>
    <name>A0A177C5I1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">alpha-1,2-Mannosidase</fullName>
            <ecNumber evidence="7">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CC84DRAFT_1262053</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the glycosyl hydrolase 47 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="7"/>
    <dbReference type="EMBL" id="KV441556">
        <property type="protein sequence ID" value="OAG02028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032393.1">
        <property type="nucleotide sequence ID" value="XM_018185122.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C5I1"/>
    <dbReference type="FunCoup" id="A0A177C5I1">
        <property type="interactions" value="535"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177C5I1"/>
    <dbReference type="GeneID" id="28768608"/>
    <dbReference type="InParanoid" id="A0A177C5I1"/>
    <dbReference type="OrthoDB" id="8118055at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044322">
        <property type="term" value="C:endoplasmic reticulum quality control compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004571">
        <property type="term" value="F:mannosyl-oligosaccharide 1,2-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904380">
        <property type="term" value="P:endoplasmic reticulum mannose trimming"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044674">
        <property type="entry name" value="EDEM1/2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001382">
        <property type="entry name" value="Glyco_hydro_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036026">
        <property type="entry name" value="Seven-hairpin_glycosidases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45679:SF5">
        <property type="entry name" value="ER DEGRADATION-ENHANCING ALPHA-MANNOSIDASE-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45679">
        <property type="entry name" value="ER DEGRADATION-ENHANCING ALPHA-MANNOSIDASE-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01532">
        <property type="entry name" value="Glyco_hydro_47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00747">
        <property type="entry name" value="GLYHDRLASE47"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48225">
        <property type="entry name" value="Seven-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008057746" description="alpha-1,2-Mannosidase" evidence="9">
        <location>
            <begin position="40"/>
            <end position="1124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="977"/>
            <end position="1056"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="986"/>
            <end position="997"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1018"/>
            <end position="1030"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="170"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="351"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="462"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="483"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="569"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAG02028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="1124" mass="124710" checksum="3169F1820291CF60" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C6U7</accession>
    <name>A0A177C6U7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DnaJ-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_934926</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG02841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033206.1">
        <property type="nucleotide sequence ID" value="XM_018187904.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C6U7"/>
    <dbReference type="STRING" id="1460663.A0A177C6U7"/>
    <dbReference type="GeneID" id="28771390"/>
    <dbReference type="InParanoid" id="A0A177C6U7"/>
    <dbReference type="OrthoDB" id="376357at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000390">
        <property type="term" value="P:spliceosomal complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052094">
        <property type="entry name" value="Pre-mRNA-splicing_ERAD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44313">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44313:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="7">
        <location>
            <begin position="17"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="92"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAG02841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="327" mass="37562" checksum="8F92E34B6C348ACD" modified="2016-09-07" version="1">MADNKDLEEVAKNTTEDFYELLGVDILAEESAIKRQYRKTSVKYHPDKNPDNAQAAEQFILLGIARDILLDPALKGEYDRQRQRRQERELEKGRLGAQRRQMVEELERAEREGVQNLKRQREAATERDQLIARLAEEGRKKRQEYQDRVQKEKQDEELKAQLDRSVKVRFRREGEAATWDKDILTSMFERYGHIDAVVIGGDKKVKVPGEKHRRLEATVTVVYERLDSAQAAVTGGKVDYPFLESVAWASKESEARSDLKAQFSAPSTPLGTPQPNKTFKTSFGIGKGLGAAPGRPQFANLKELEEYTLKRCKEVDERKRMQREQAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C813</accession>
    <name>A0A177C813_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1166989</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aegerolysin family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG03271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033636.1">
        <property type="nucleotide sequence ID" value="XM_018179100.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C813"/>
    <dbReference type="GeneID" id="28762586"/>
    <dbReference type="InParanoid" id="A0A177C813"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019836">
        <property type="term" value="P:symbiont-mediated hemolysis of host erythrocyte"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.270.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009413">
        <property type="entry name" value="Aegerolysin-typ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06355">
        <property type="entry name" value="Aegerolysin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG03271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="170" mass="19214" checksum="003BC986636123CC" modified="2016-09-07" version="1">MGNTISTIGNGMVQTVKEIPGYVKEQFTPGPPSPNVVFALENNSKEYDIRFANVKLPSGYFHDPPHNNFDSVVSVDHIQDFANRTRAFSTTAYWVAASYWTLHGGLLTGIEGSMDLMACRDGTEKKIGEMSWNWNNIRKITTAKSTDDGWEVKEMQPLINQDWRVIVRQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2023-06-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C8F2</accession>
    <name>A0A177C8F2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_883500</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG04024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034389.1">
        <property type="nucleotide sequence ID" value="XM_018187774.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C8F2"/>
    <dbReference type="GeneID" id="28771260"/>
    <dbReference type="InParanoid" id="A0A177C8F2"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG04024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="170" mass="19334" checksum="8C2B207FBE76809A" modified="2016-09-07" version="1">MGDTCSAATLFGPMQTRYRLGVVLCAKRSWISPLLSSDVQHGKSTVIFRRIGHKWSVPTLPGPGAVWNYDDNRKLSSWAMWTILHFKSKDVTRSWWDIDIIHRLLTFLRNRPKEPGDSIQAQLTVGKVSVVARSGYNKQADPVLCMYIGNSIPEWVHRYCDGLETQAVHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C8R4</accession>
    <name>A0A177C8R4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Annexin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CC84DRAFT_1097843</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the annexin family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG03147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033512.1">
        <property type="nucleotide sequence ID" value="XM_018174736.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C8R4"/>
    <dbReference type="STRING" id="1460663.A0A177C8R4"/>
    <dbReference type="GeneID" id="28758222"/>
    <dbReference type="InParanoid" id="A0A177C8R4"/>
    <dbReference type="OrthoDB" id="37886at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012506">
        <property type="term" value="C:vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005544">
        <property type="term" value="F:calcium-dependent phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001786">
        <property type="term" value="F:phosphatidylserine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.10:FF:000005">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.10">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001464">
        <property type="entry name" value="Annexin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018502">
        <property type="entry name" value="Annexin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037104">
        <property type="entry name" value="Annexin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009117">
        <property type="entry name" value="ANX14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10502">
        <property type="entry name" value="ANNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10502:SF102">
        <property type="entry name" value="ANNEXIN B11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00191">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00196">
        <property type="entry name" value="ANNEXIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01813">
        <property type="entry name" value="ANNEXINFUNGI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00335">
        <property type="entry name" value="ANX"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47874">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51897">
        <property type="entry name" value="ANNEXIN_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0041">Annexin</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="389"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="67"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="136"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAG03147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="470" mass="51475" checksum="558F917A56CB9360" modified="2016-09-07" version="1">MYGQQPPNQGGWNQAPPPQGQYGYNAPPPQQGWGAPPPQGNYPPPQQGYQQQYGAPPPQQGQGHWGAPPPGGQPGYGAPPPNQYGSPAPPQGGYQQPPPGQYGAPPPQGGYGQPPPQQYGAPPPQQPGYGAPPPQQYGQQYGAPQSFGPPTQPSLGYGPQRTANIDVTQDVEGIRKAMKGFGTNEKVLIQILAKKDPIQINTIRQAYNQRMLRDLIKDLEKETSGYFEKGLVQIARGPLIGDCYTLYEAMKGLGTKEAALDDVLIGRSNADVNAIKAEYQNIFKKTLEADLRGDLSAATEKMYMMVIAARRAEDSNPVMPQAVEQDVTELQRGMGNMISKNASSVCDLLFTRNDAQIRAIAQSYQQRFHEPLVKTIKSKFSGHMEDALVLLVERAINRAEAEATRLEDSMAGLGTKDELLVQRVVRCHWDQGFMRAVSDAYQRKYGKSLVRRIEGETRGDYEKLMVACVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C938</accession>
    <name>A0A177C938_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Lytic polysaccharide monooxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1166051</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG03896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034261.1">
        <property type="nucleotide sequence ID" value="XM_018178863.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C938"/>
    <dbReference type="STRING" id="1460663.A0A177C938"/>
    <dbReference type="GeneID" id="28762349"/>
    <dbReference type="InParanoid" id="A0A177C938"/>
    <dbReference type="OrthoDB" id="2342176at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36182">
        <property type="entry name" value="PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G10930)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36182:SF1">
        <property type="entry name" value="PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G10930)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008057958" description="Lytic polysaccharide monooxygenase" evidence="2">
        <location>
            <begin position="18"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="206"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG03896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="346" mass="37445" checksum="FB23EFF0D1FD901D" modified="2016-09-07" version="1">MHASKLLFLALGGLVQSHMHLYYPPTLKGENNPHTQGESDPYLNYNYGCCGREVPGPCKGHLDLVDTDEGKPVVTWAPGQKVNFTLSGSSTTEVKGGTHYGGSCSVGFSTDKGKTFKVATTWNGNCPHREGSIDPSTQSFDFTVPADLPAGDRTIFAWTWINREKEFNMNCAVVTIAGSDQSEDPGYQPAPSSAAPKPSSPPSQPPKSQSSKAPQRPTQTQPSSSQPTGSAQYTLEGCTCSCPYQTWSSACSCYECKSPTTKRHLVERKVLELHKRHLQNAEKLNVPVRRAETVAWTSRPDMLLSIDFPGASCHSKGNPFELEFPDPGPDVVDGDGEYKLAGPDCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C9H1</accession>
    <name>A0A177C9H1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Sodium/calcium exchanger membrane region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CC84DRAFT_1198234</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC24A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG03370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033735.1">
        <property type="nucleotide sequence ID" value="XM_018181555.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C9H1"/>
    <dbReference type="STRING" id="1460663.A0A177C9H1"/>
    <dbReference type="GeneID" id="28765041"/>
    <dbReference type="InParanoid" id="A0A177C9H1"/>
    <dbReference type="OrthoDB" id="2127281at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005262">
        <property type="term" value="F:calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008273">
        <property type="term" value="F:calcium, potassium:sodium antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="entry name" value="NCX, central ion-binding region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004481">
        <property type="entry name" value="K/Na/Ca-exchanger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10846:SF8">
        <property type="entry name" value="INNER MEMBRANE PROTEIN YRBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10846">
        <property type="entry name" value="SODIUM/POTASSIUM/CALCIUM EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0050">Antiport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="72"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="133"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="239"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="267"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="298"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="336"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="363"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="9">
        <location>
            <begin position="11"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="9">
        <location>
            <begin position="239"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="162"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="165"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="210"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAG03370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="390" mass="41937" checksum="ECD16210556D7EB6" modified="2016-09-07" version="1">MANADVVAYNIAAFIATLFLLEFGADKFIDHTAVVAYRINIPETVIGLVTAGGEWEELAVVIASLASNRASLAIGNIVGSAISNILGAFSLGLLFHDKHKPIHFDRSSRIYSLVLLVLTTFVAPITYFSTRTIWLVCGSILIVFFAIYIGSVGWAISKGTLTAPEDSESDGSSDDESSDGESTTDIAERIPAGADRYEDETSGPARVEPNEQTNPDASSITLRPPGTSHRKRRTLRYHLFYLFLGFLAICLAGYVLSHAAINIIDEFGISDVLFGVVILAIATTLPEKFVAVMSGHRGHAGILVANTAGSNIFLLALCSGIVMLDTSGKFERGNVSIPELGVLWCSTLAFTVTVWFGGRFCRWIGFGMLIAYIAFIVLEFTVIHGVANGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CAD8</accession>
    <name>A0A177CAD8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Membrane transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CC84DRAFT_1096371</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG03727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034092.1">
        <property type="nucleotide sequence ID" value="XM_018174662.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CAD8"/>
    <dbReference type="FunCoup" id="A0A177CAD8">
        <property type="interactions" value="140"/>
    </dbReference>
    <dbReference type="GeneID" id="28758148"/>
    <dbReference type="InParanoid" id="A0A177CAD8"/>
    <dbReference type="OrthoDB" id="6730379at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17327">
        <property type="entry name" value="MFS_FEN2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000064">
        <property type="entry name" value="MFS allantoate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF1">
        <property type="entry name" value="ALLANTOATE PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="49"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="95"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="125"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="149"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="184"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="221"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="283"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="325"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="353"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="382"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="414"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="447"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="49"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAG03727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="506" mass="56445" checksum="B7CF2909B957706B" modified="2016-09-07" version="1">MVKHVDDQILKHSHDADAAMKAFEGYDGQTIELSPETNKRLLRKIDRHLMPILCIVYGLNYLDKTTLSYASIMGLKLPPSDDKLKSGIGITGSQYSWLSSLFYFGYLAWEYPTSRLLQRLPLGKYSAFNIIMWGIVLSCFAAVENYSGAIAIRFFLGVFEAAVTPGFALFTSQWYTKKEQGFRTGIWFSFNGFAQIFGGVVAYGIAVGARKHGTLIEPWKLIFLVTGLLTTAIGILFLWIVPDNQLNCRWLSKEDRILAIERIRMNGQGVGNKHFKLYQLKEALLDPMAWAFFWYALVADIPNGGLSNFFSQLIVGFGYTPEESLLYGTPGGAVEIVALISCGWLGDKLGYRILVSMSGMCLALLGMILIVALPLSNNSGRLAGYYLTQASPTPFVAILSLISSNVAGYTKKTTVAAMFLIGYCTGNIIGPQTFRAKDAPRYVPAEITIIVCYALCLVIMAFIHVYCVWQNKKKEKIRAAEGYVKLENQEWLDLTDKENPEFVYTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2023-06-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CAL3</accession>
    <name>A0A177CAL3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_865894</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG03760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034125.1">
        <property type="nucleotide sequence ID" value="XM_018187706.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CAL3"/>
    <dbReference type="GeneID" id="28771192"/>
    <dbReference type="InParanoid" id="A0A177CAL3"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG03760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="98" mass="11069" checksum="7E1C4092891B755F" modified="2016-09-07" version="1">MLIVAKDARPARCDLTILPSARRNCREAHSSLYLDLQRYSLILCYLSLFSSLPSSLQISIAANEQGVFKESCWTAWTEQATSRLIKRFLASEADMLRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CAU1</accession>
    <name>A0A177CAU1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_867544</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG03810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034175.1">
        <property type="nucleotide sequence ID" value="XM_018187720.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CAU1"/>
    <dbReference type="FunCoup" id="A0A177CAU1">
        <property type="interactions" value="691"/>
    </dbReference>
    <dbReference type="GeneID" id="28771206"/>
    <dbReference type="InParanoid" id="A0A177CAU1"/>
    <dbReference type="OrthoDB" id="5386330at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053157">
        <property type="entry name" value="Sterol_Uptake_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47784">
        <property type="entry name" value="STEROL UPTAKE CONTROL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47784:SF4">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00755">
        <property type="entry name" value="AFLATOXINBRP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="21"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="10"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAG03810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="407" mass="45842" checksum="AC5AC2936C237A09" modified="2016-09-07" version="1">MPSGDMNATKTRKPHRKSRSGCTSCKARHVKCDEQKPICSNCEKYGSTCEYPRLKRAGVSDHREVALSPAALNTPSPAHSAVVNRSNHDGMENQEMIADIVHLRLLHHFITVTASTLAHAPDAADVFSSYIPKVAFDNPYVLHAILSLTALHLSRLEPPRRVDYILKARRHHQIALAQFRAEVKDISASNLQVVLIFNALLFPYTCAISASLTDFEDVFESIFSNLIVTRMVGPLIQASGLYESMLHSDLGRIIPKDVHSVDWKNAEAPQETQLVQLRKFSEVIHHVYPPEINEAYKEAIGRLDLLFDVISKSAEPPSDSLLRLWIHFVPSRFVELLSEKQPGALIIFAHYGVLLGRGRHYWFLEGMDEMILAVADAFVPIEWKSWLDWPKEQIRACRTPISQPTST</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CBA7</accession>
    <name>A0A177CBA7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">mitogen-activated protein kinase kinase</fullName>
            <ecNumber evidence="6">2.7.12.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CC84DRAFT_1054297</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.12.2" evidence="6"/>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG04953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035318.1">
        <property type="nucleotide sequence ID" value="XM_018173522.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CBA7"/>
    <dbReference type="STRING" id="1460663.A0A177CBA7"/>
    <dbReference type="GeneID" id="28757008"/>
    <dbReference type="InParanoid" id="A0A177CBA7"/>
    <dbReference type="OrthoDB" id="310217at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004708">
        <property type="term" value="F:MAP kinase kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48013:SF9">
        <property type="entry name" value="DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48013">
        <property type="entry name" value="DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="1"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00051693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OAG04953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="308" mass="35738" checksum="AAB51C340160C854" modified="2016-09-07" version="1" fragment="single">FTFVRDIGYGTEGTVSRWENRTAGQVVALKVPRTPDRSKDLLAEIVALKKVPPHENITNFLTYILQHEPVGPALVFELAQWGDVSKFRRTFLRYVDKVPEMTLWKFLVDMSLALDWLHNQMGEGHIHGDLKPENILVFSPPGWKGAHDKLPTLPTFKISDIARMKPASANIKYHGTYEFGPPLKERERKQTPAADVWAIGASLQNFALGVMPVKNKDEYIKEKEEEGGYVPTLEDLRTEKWRKIIPHQYRPINMSEDYQRYNMNIEPTAPYSFDLQRWYERLYAEDISKRASSKWLVKKYVPYAEVKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CC60</accession>
    <name>A0A177CC60_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Scramblase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1164924</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the phospholipid scramblase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG04462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034827.1">
        <property type="nucleotide sequence ID" value="XM_018178601.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CC60"/>
    <dbReference type="FunCoup" id="A0A177CC60">
        <property type="interactions" value="169"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CC60"/>
    <dbReference type="GeneID" id="28762087"/>
    <dbReference type="InParanoid" id="A0A177CC60"/>
    <dbReference type="OrthoDB" id="191150at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017128">
        <property type="term" value="F:phospholipid scramblase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005552">
        <property type="entry name" value="Scramblase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23248:SF9">
        <property type="entry name" value="PHOSPHOLIPID SCRAMBLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23248">
        <property type="entry name" value="PHOSPHOLIPID SCRAMBLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03803">
        <property type="entry name" value="Scramblase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="18"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="477"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="516"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="530"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG04462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="552" mass="58221" checksum="6AB542E814632291" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CC69</accession>
    <name>A0A177CC69_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative cell-associated beta-galactosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CC84DRAFT_1248076</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG05253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035618.1">
        <property type="nucleotide sequence ID" value="XM_018184247.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CC69"/>
    <dbReference type="STRING" id="1460663.A0A177CC69"/>
    <dbReference type="GeneID" id="28767733"/>
    <dbReference type="InParanoid" id="A0A177CC69"/>
    <dbReference type="OrthoDB" id="408532at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036156">
        <property type="entry name" value="Beta-gal/glucu_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054593">
        <property type="entry name" value="Beta-mannosidase-like_N2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032311">
        <property type="entry name" value="DUF4982"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051913">
        <property type="entry name" value="GH2_Domain-Containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040605">
        <property type="entry name" value="Glyco_hydro2_dom5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006102">
        <property type="entry name" value="Ig-like_GH2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42732">
        <property type="entry name" value="BETA-GALACTOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42732:SF1">
        <property type="entry name" value="BETA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16355">
        <property type="entry name" value="DUF4982"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18565">
        <property type="entry name" value="Glyco_hydro2_C5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00703">
        <property type="entry name" value="Glyco_hydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22666">
        <property type="entry name" value="Glyco_hydro_2_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49303">
        <property type="entry name" value="beta-Galactosidase/glucuronidase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008058010" evidence="5">
        <location>
            <begin position="20"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-mannosidase-like galactose-binding" evidence="9">
        <location>
            <begin position="78"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 2 immunoglobulin-like beta-sandwich" evidence="6">
        <location>
            <begin position="208"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4982" evidence="7">
        <location>
            <begin position="616"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 2" evidence="8">
        <location>
            <begin position="697"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="805"/>
            <end position="824"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF16355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF18565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF22666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAG05253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="948" mass="105545" checksum="E7212829E9376F17" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2023-06-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CC76</accession>
    <name>A0A177CC76_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_790702</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG04368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034733.1">
        <property type="nucleotide sequence ID" value="XM_018187398.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CC76"/>
    <dbReference type="GeneID" id="28770884"/>
    <dbReference type="InParanoid" id="A0A177CC76"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG04368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="116" mass="12589" checksum="57FEF53D7AB0265A" modified="2016-09-07" version="1">MLDPVACFTQWQSMAPLRHGLCLQALLCASTDSEEKIATPRCCSLHRMLARCGGVGSACLIAISPEEPRPVGSPSASRRMVALHPPASASSTWIVHDFEAQAIRQLFDSVHHKIPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CCB2</accession>
    <name>A0A177CCB2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_790449</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG04360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034725.1">
        <property type="nucleotide sequence ID" value="XM_018187393.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CCB2"/>
    <dbReference type="STRING" id="1460663.A0A177CCB2"/>
    <dbReference type="GeneID" id="28770879"/>
    <dbReference type="InParanoid" id="A0A177CCB2"/>
    <dbReference type="OrthoDB" id="3759773at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG04360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="612" mass="68372" checksum="8DF29B09AAEF995D" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CCT5</accession>
    <name>A0A177CCT5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CC84DRAFT_1196733</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 'GDXG' lipolytic enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG04617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034982.1">
        <property type="nucleotide sequence ID" value="XM_018181484.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CCT5"/>
    <dbReference type="STRING" id="1460663.A0A177CCT5"/>
    <dbReference type="GeneID" id="28764970"/>
    <dbReference type="InParanoid" id="A0A177CCT5"/>
    <dbReference type="OrthoDB" id="2152029at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033140">
        <property type="entry name" value="Lipase_GDXG_put_SER_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF31">
        <property type="entry name" value="STERYL ACETYL HYDROLASE MUG81-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01174">
        <property type="entry name" value="LIPASE_GDXG_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="5">
        <location>
            <begin position="115"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAG04617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="390" mass="42940" checksum="CD611284BD2F1E97" modified="2016-09-07" version="1">MANISPPSTSTWLLLAARVLLAVIFRLLTTPIRWFTDSGAATFFEDIFFTVFRALLRHASFAVSRAIFKPTTEAYGELCRKTGREARSLAVQGKRREIEGLKAHWIGEEAAEVVVLYLHGGGYTQPASPDHLTYLDGLTKDINIGTGSTSSISFLVLAYSLAPEQAVYPTQLRQAAATLDHLVNVSGRSPSSIMLSGDSAGGALALALLSHILHPKAGVPRVEVQVPLRGVMLFSPWVSFSTAFNSYERNAESDTLSAYILKKWATMYLGEMDADSKHQVTWDVKSNDVYAEAYLADPQWWSGLNHVVESMLVWVGGKELLHDPVTEFVSKLKKGWKRRDEAHIGPILNVSLGNKTKRGSQLAIEAWLMERFNAVSNKSPAVRLRTAIAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CD10</accession>
    <name>A0A177CD10_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1218457</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG05071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035436.1">
        <property type="nucleotide sequence ID" value="XM_018183001.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CD10"/>
    <dbReference type="STRING" id="1460663.A0A177CD10"/>
    <dbReference type="GeneID" id="28766487"/>
    <dbReference type="InParanoid" id="A0A177CD10"/>
    <dbReference type="OrthoDB" id="3800349at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="273"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="428"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="101"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="275"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="324"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="345"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG05071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="447" mass="49589" checksum="856290D3DCA3C7FD" modified="2016-09-07" version="1">MSVLAFKALDYGADKLPDRIFEAIPGGFFTPDHKRHPKSKTKRRPLLDSRGKSEQRNDRGRRRSQRERTPPSEHLGYSSYDDSDYERDQRRQGRRRRVKSLGRSPSRSLSRSSSRGRHHHQRSSGFDGEGDERAQMDRERADRGPQFPPPPTSEYRQYNPQGYASPPPPATGGQYDPYRPAQSARQDQGYPPQVNTTTSRSRSATLPAGRPAPTPLQILRSKLMSRSPSNMSTPLLPVSPLHTPPTMESLRIGTPLGASFLPSYEPPLAALLSRPATNSPQPTSHTAARYTPGAGYAPSPVNVNSPIPPPPNNGYAPYNPADYASSNAGYPTAGNTYPSPPPFYRQSSRSQPSLAQYPYPDSQVAAYDSPPDRHGSSSSSRRHRHQDDRRHRARSAGQHGRSRSRVTDKFRDRFESMDLHDKNLAASVGGAGIGAFGGRELEKRHDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CD43</accession>
    <name>A0A177CD43_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">phosphoribosylamine--glycine ligase</fullName>
            <ecNumber evidence="2">6.3.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Glycinamide ribonucleotide synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Phosphoribosylglycinamide synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CC84DRAFT_1118894</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + ATP = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23032"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:137981"/>
            <dbReference type="ChEBI" id="CHEBI:147287"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.3.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; IMP biosynthesis via de novo pathway; N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the GARS family.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.13" evidence="2"/>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG05593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035958.1">
        <property type="nucleotide sequence ID" value="XM_018175535.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CD43"/>
    <dbReference type="FunCoup" id="A0A177CD43">
        <property type="interactions" value="1155"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CD43"/>
    <dbReference type="GeneID" id="28759021"/>
    <dbReference type="InParanoid" id="A0A177CD43"/>
    <dbReference type="OrthoDB" id="2018833at2759"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00125"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004637">
        <property type="term" value="F:phosphoribosylamine-glycine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004641">
        <property type="term" value="F:phosphoribosylformylglycinamidine cyclo-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009113">
        <property type="term" value="P:purine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.20:FF:000006">
        <property type="entry name" value="Phosphoribosylamine--glycine ligase, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.20:FF:000006">
        <property type="entry name" value="phosphoribosylamine--glycine ligase, chloroplastic-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000018">
        <property type="entry name" value="Trifunctional purine biosynthetic protein adenosine-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.600.10:FF:000001">
        <property type="entry name" value="Trifunctional purine biosynthetic protein adenosine-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.600.10">
        <property type="entry name" value="Phosphoribosylglycinamide synthetase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00138">
        <property type="entry name" value="GARS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020561">
        <property type="entry name" value="PRibGlycinamid_synth_ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000115">
        <property type="entry name" value="PRibGlycinamide_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020560">
        <property type="entry name" value="PRibGlycinamide_synth_C-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037123">
        <property type="entry name" value="PRibGlycinamide_synth_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020559">
        <property type="entry name" value="PRibGlycinamide_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020562">
        <property type="entry name" value="PRibGlycinamide_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00877">
        <property type="entry name" value="purD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43472">
        <property type="entry name" value="PHOSPHORIBOSYLAMINE--GLYCINE LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43472:SF1">
        <property type="entry name" value="PHOSPHORIBOSYLAMINE--GLYCINE LIGASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01071">
        <property type="entry name" value="GARS_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02843">
        <property type="entry name" value="GARS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02844">
        <property type="entry name" value="GARS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01209">
        <property type="entry name" value="GARS_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01210">
        <property type="entry name" value="GARS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="Rudiment single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00184">
        <property type="entry name" value="GARS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 15" id="KW-0436">Ligase</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="14">
        <location>
            <begin position="117"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00042242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00042864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OAG05593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="430" mass="45936" checksum="9E6A610F68868BEC" modified="2016-09-07" version="1">MTDKLRVLLVGNGGREHAIAWKLAQSPRVEHIYVVPGNGGTASSANTTNVPSIKQEDFPALVQFAKEKNINLLVPGPEAPLVAGIVDYFEKHGDKSVRFFGPSEAAARMEGSKTFSKDFMKRNNIPTAAYENFSDYEKAKAYLDSIDHNVVIKASGLAAGKGVLIPQTKEEAHAGLKDIMLDREFGAAGDEVVIEEFLEGDELSILTFSDGATIKSLPPAQDHKRIGDGDTGPNTGGMGTYAPTRIAPPEVIEAVHKDILQPTVDGMKKEGYTFKGVLFTGLMMTKQGPKVLEYNVRFGDPETQSLLALMESDLAEVMVACAEGRLSEVDVKVGNKSAATVVVAAGGYPGSYAKGTVMTLDQVPEDVVLFHAGTSLIDNTLKTAGGRVIASTATAATLEEAVAKAYKGVDCIHFDGMQYRKDIAGRALKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CD92</accession>
    <name>A0A177CD92_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Apple domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1260069</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG04747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035112.1">
        <property type="nucleotide sequence ID" value="XM_018184966.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CD92"/>
    <dbReference type="STRING" id="1460663.A0A177CD92"/>
    <dbReference type="GeneID" id="28768452"/>
    <dbReference type="InParanoid" id="A0A177CD92"/>
    <dbReference type="OrthoDB" id="5358884at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG04747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="263" mass="28003" checksum="4ACA35D2E2FEC4CE" modified="2016-09-07" version="1">MSNLPEVALPTTGLEVDHSASAPPAGVNYVAPHYYGEQQQRLPSKGEYAPVGSEDRSVPKDSATVCGVRRSTFWLTVILAIVVVAAAVGGGVGGSMAVSNARSDAQSGSSGSARETVTVTATVCSTSAPEPTSTSVSEDDPPYVPKEAWRVNSINGSCPTPVMQNTHVDNRPDDKYNCREGRDFGGFDIMWFTSYTLQACIDACSNYNVANKTQTPCKGVALALDLRQQYYVNGGANCWLKSEANEAGSSEKKTNTFAWLENQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CDE6</accession>
    <name>A0A177CDE6_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ubiquitin-like 1-activating enzyme E1A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_1186841</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein sumoylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ubiquitin-activating E1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG05663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036028.1">
        <property type="nucleotide sequence ID" value="XM_018180883.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CDE6"/>
    <dbReference type="FunCoup" id="A0A177CDE6">
        <property type="interactions" value="1178"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CDE6"/>
    <dbReference type="GeneID" id="28764369"/>
    <dbReference type="InParanoid" id="A0A177CDE6"/>
    <dbReference type="OrthoDB" id="1708823at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031510">
        <property type="term" value="C:SUMO activating enzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019948">
        <property type="term" value="F:SUMO activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016925">
        <property type="term" value="P:protein sumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01492">
        <property type="entry name" value="Aos1_SUMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000011">
        <property type="entry name" value="UBQ/SUMO-activ_enz_E1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF162">
        <property type="entry name" value="SUMO-ACTIVATING ENZYME SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01849">
        <property type="entry name" value="UBIQUITINACT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="THIF-type NAD/FAD binding fold" evidence="7">
        <location>
            <begin position="44"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAG05663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="398" mass="43018" checksum="FEF0E62E59B7BF3E" modified="2016-09-07" version="1">MADPAATLPATNGQAALAAPDAAGELAASMAQAATVSADEIALYDRQIRLWGLEAQNRIRNANILLVNIKALANEIAKNLVLAGIGSITLADHGVVAQEDLGAQFFVTEADVGSNRAQAAAPQVQKLNPRVKVNVLTHDVSKETDTSFFVPFDLIIATDLDFIGLTNINSCARIANRPFYAGGTHGMYGYIFADLGQHDFVIEREVSRKTELKAESATRSVTAVRFKKENGKNIELVTKRELYTPLLLSNTSPLAPELQGNTRKLKKVHPLLTCIRTLWEWQRQGNGSPLAALPAFTASAMDRHKELTLPAETLTGDFLRDFLSNLDCEIAPVTAYLGGQLAQDVINVLGKREQPIQNLMLFDGEDSSGPVYALHPIFVNDPVPPIVPLPVDAPIVLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CDY3</accession>
    <name>A0A177CDY3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ferric-chelate reductase (NADPH)</fullName>
            <ecNumber evidence="3">1.16.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CC84DRAFT_1187877</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>2 a Fe(II)-siderophore + NADP(+) + H(+) = 2 a Fe(III)-siderophore + NADPH</text>
            <dbReference type="Rhea" id="RHEA:28795"/>
            <dbReference type="Rhea" id="RHEA-COMP:11342"/>
            <dbReference type="Rhea" id="RHEA-COMP:11344"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.16.1.9"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ferric reductase (FRE) family.</text>
    </comment>
    <dbReference type="EC" id="1.16.1.9" evidence="3"/>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG04988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035353.1">
        <property type="nucleotide sequence ID" value="XM_018180959.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CDY3"/>
    <dbReference type="STRING" id="1460663.A0A177CDY3"/>
    <dbReference type="GeneID" id="28764445"/>
    <dbReference type="InParanoid" id="A0A177CDY3"/>
    <dbReference type="OrthoDB" id="3944240at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052851">
        <property type="term" value="F:ferric-chelate reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015677">
        <property type="term" value="P:copper ion import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013112">
        <property type="entry name" value="FAD-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051410">
        <property type="entry name" value="Ferric/Cupric_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361:SF9">
        <property type="entry name" value="FERRIC REDUCTASE TRANSMEMBRANE COMPONENT 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361">
        <property type="entry name" value="FERRIC/CUPRIC REDUCTASE TRANSMEMBRANE COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08022">
        <property type="entry name" value="FAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00052">
        <property type="entry name" value="Ferric_Reductase_Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01168">
        <property type="entry name" value="Ferric_reductase_subgroup_(FRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="15"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="95"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="133"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="166"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="201"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="230"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="16">
        <location>
            <begin position="263"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="515"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="595"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="523"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="600"/>
            <end position="611"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="OAG04988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="690" mass="77365" checksum="EBC0B10C8A102F87" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CEB6</accession>
    <name>A0A177CEB6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Oxidoreductase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CC84DRAFT_1165474</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG05149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035514.1">
        <property type="nucleotide sequence ID" value="XM_018178723.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CEB6"/>
    <dbReference type="FunCoup" id="A0A177CEB6">
        <property type="interactions" value="241"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CEB6"/>
    <dbReference type="GeneID" id="28762209"/>
    <dbReference type="InParanoid" id="A0A177CEB6"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05327">
        <property type="entry name" value="retinol-DH_like_SDR_c_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF282">
        <property type="entry name" value="WW DOMAIN-CONTAINING OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAG05149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="312" mass="33970" checksum="7BA13EB4F0A0FA30" modified="2016-09-07" version="1">MAPSAQFNPATDIPSLAGKVVLVTGGNAGLGKQTIAYLAAHSPARIYLAARTASKAESAIADIQREAPSAVIEYLPLDLTSFSSIAEAASTFKAREQRLDILVNNAGIMMTPFSFTKEGYEIQFGTNHVGHALFTKLLMPVLLQTAEQPGADVRIINVSSMGMFAAPSGGIIFNQAALEKEYTWRRYGQSKLANILFTRELSARYPQITSVSVHPGVIITDLYNAFVSGPIMKGMFWFYKQLVPILPGHFKDVTGGALAQTHLATADRSTIQNGEFYRPVGIVTKGSSYSQDLGLARKLWEWTEEEFGKHGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CEI4</accession>
    <name>A0A177CEI4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SMP-30/Gluconolactonase/LRE-like region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1165476</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG05150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035515.1">
        <property type="nucleotide sequence ID" value="XM_018178724.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CEI4"/>
    <dbReference type="STRING" id="1460663.A0A177CEI4"/>
    <dbReference type="GeneID" id="28762210"/>
    <dbReference type="InParanoid" id="A0A177CEI4"/>
    <dbReference type="OrthoDB" id="9977941at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052998">
        <property type="entry name" value="Hetero-Diels-Alderase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42060:SF1">
        <property type="entry name" value="NHL REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42060">
        <property type="entry name" value="NHL REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008058185" description="SMP-30/Gluconolactonase/LRE-like region domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG05150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="332" mass="34670" checksum="AC09BB14AB42F263" modified="2016-09-07" version="1">MRSSGLFTVATVSGMSLAATVRTIHQFPNPTWVENVASTRNGSLLVGILGQVPAQLHILDPFSNTTQDTLLHTFAPSNSIFGITEYETDVFAVAAGNFSFTTANGTGDANIWSVDLRSGTTKSSIKVHKLVHLPDAQINGIAALNSKALLFADSWAGNIRRVDIKTGKHEVVLEDATTANNVSSPLPLGANGLKILRPNAVPSSRDTPTLYFSNLQLSKMYSVPIDGNTGRPQGRVTTLASGLGSVIDDLAVTDDGTVFLTRDAANDVVRISGDGEAATLGGGNATVLGPTAAALGRTYRDRGVLYVSAMGGQQADGTFTEGGRVVAIDLDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CEM1</accession>
    <name>A0A177CEM1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CC84DRAFT_1218584</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG05217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035582.1">
        <property type="nucleotide sequence ID" value="XM_018183014.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CEM1"/>
    <dbReference type="STRING" id="1460663.A0A177CEM1"/>
    <dbReference type="GeneID" id="28766500"/>
    <dbReference type="InParanoid" id="A0A177CEM1"/>
    <dbReference type="OrthoDB" id="444631at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF47">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="46"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="89"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="125"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="174"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="204"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="30"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="295"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="496"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="333"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="356"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="517"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAG05217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="526" mass="57640" checksum="AB5FA4DF9717E7C7" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CEY8</accession>
    <name>A0A177CEY8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CC84DRAFT_1187169</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG06175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036540.1">
        <property type="nucleotide sequence ID" value="XM_018180910.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CEY8"/>
    <dbReference type="GeneID" id="28764396"/>
    <dbReference type="InParanoid" id="A0A177CEY8"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000090">
        <property type="entry name" value="MFS sugar transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF80">
        <property type="entry name" value="SUGAR TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12170)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="136"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="169"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="259"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="300"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="327"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="360"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="398"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="429"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="9"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAG06175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="503" mass="55268" checksum="B4FA3C83CC52C86D" modified="2016-09-07" version="1">MGLGFNIALAIFAGTGSFLFGYDSGVMTDVIQSPHFLKFFNTNPETAIIGAINSTFSGGAVFGSLMGGLTMDSLGRRWTVLVGAVINLVGAAMQSGAQNLAMILVGRILAGWAVGVLSMSVPIYQSECAHPSKRGLIVGITQQMIGIGFIVSTWVGYGSAHVPETSSFSWRFPLGFQCIPCLILICGIMFFPESPRYLVETDRADEALTVLRRLHFNGRNEDDIQAQFHEIKTTIEAEKAVTAPGWLIMFKVKQWRTRLLHATFMQVFTQMTGINVIGYYQTVMYKNLGIEGKRNLLVTGIYNVVGPVFNAFFITFLLDKVGRRKPLLFGTIGITIALICEAAIGSQVPSATGARKDSLSIAGVFFIFSVSAIFSCSFGPISWVYASEIMPLSIRGRGSAFATGIGNWLVSTVWSQVSPIALADITYKFYFIFVAWNLFVTLPAVFFLWKETKQLSLEEIDLLFGDRALGTLPDHLGDAKEADVVHEEAKRLYLDNFRITRIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CH88</accession>
    <name>A0A177CH88_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Peptidase S54 rhomboid domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CC84DRAFT_1217550</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S54 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG06312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036677.1">
        <property type="nucleotide sequence ID" value="XM_018182903.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CH88"/>
    <dbReference type="STRING" id="1460663.A0A177CH88"/>
    <dbReference type="GeneID" id="28766389"/>
    <dbReference type="InParanoid" id="A0A177CH88"/>
    <dbReference type="OrthoDB" id="418595at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022764">
        <property type="entry name" value="Peptidase_S54_rhomboid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050925">
        <property type="entry name" value="Rhomboid_protease_S54"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43731:SF14">
        <property type="entry name" value="PRESENILIN-ASSOCIATED RHOMBOID-LIKE PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43731">
        <property type="entry name" value="RHOMBOID PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01694">
        <property type="entry name" value="Rhomboid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="142"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="200"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S54 rhomboid" evidence="8">
        <location>
            <begin position="70"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAG06312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="262" mass="29333" checksum="2BEA84895B96131A" modified="2016-09-07" version="1">MQGLHDRSTDGTYSRNLKKKKEEFVLNRSSVLVSHRGLSLTVVGLNLAVFLYGRENPRNYWKLLDKPGCTWTLLTTAFCHKDLQHLSANMFSLVPEIPQVLQVCGQSPYQFVAFYISAAIISSYAQRAVSYTRWTQQWSSRFFIGEPISMGASGVAMAIFAASCFAEPPWASPSFLLSALTLVRQVTLDFGGLIHNKGNIGYAAHLAGAVFGAMYAYFNADRYLWSNLVHLFSVYLPKSPPPTPRHKDLDLDEIVRRLNESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CHK4</accession>
    <name>A0A177CHK4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Concanavalin A-like lectin/glucanase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1176303</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG06270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036635.1">
        <property type="nucleotide sequence ID" value="XM_018180209.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CHK4"/>
    <dbReference type="GeneID" id="28763695"/>
    <dbReference type="InParanoid" id="A0A177CHK4"/>
    <dbReference type="OrthoDB" id="5230873at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008058303" description="Concanavalin A-like lectin/glucanase" evidence="1">
        <location>
            <begin position="19"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG06270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="190" mass="20487" checksum="85C2DDFFA304AB4A" modified="2016-09-07" version="1">MSFTKLSLLCTLPLLALGAKFKRATPDEFGLFGYGQGFGGFPLFYADGYAYLGEPSSSNSSDPGVVTFTPSGSGTSQSWIGNPNTTLTNYTVSWSDVTFAVPTVSSSDRRVRFLTNETSDSDVVTTGFYFYGSTAFVVEGGKLESPWYALQVSERVHALYWNDTSLGQVPVILRNNPPSNPQNVPGISSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CHS1</accession>
    <name>A0A177CHS1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1216088</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG07083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037448.1">
        <property type="nucleotide sequence ID" value="XM_018182768.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CHS1"/>
    <dbReference type="GeneID" id="28766254"/>
    <dbReference type="InParanoid" id="A0A177CHS1"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG07083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="133" mass="15981" checksum="6AF93F41AE22574C" modified="2016-09-07" version="1">MQMLNEKERLEKENSELKGYKLITTNVETENPSTRQRARKAQRHREKLASMIKARDTSIQNLKEYRQEQTATIKINDETVKWQDDAIKRKDEDLETQDRTAKRQDGIMETHEEMIKRNKHRIKDLKETRSLEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CI02</accession>
    <name>A0A177CI02_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1217667</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG06450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036815.1">
        <property type="nucleotide sequence ID" value="XM_018182917.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CI02"/>
    <dbReference type="GeneID" id="28766403"/>
    <dbReference type="InParanoid" id="A0A177CI02"/>
    <dbReference type="OrthoDB" id="3766700at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG06450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="322" mass="36664" checksum="A1942C12C628A186" modified="2016-09-07" version="1">MHYASFCSNSCTPTPGKEPVDPPPRFPKIARVAPIPLSYLGKQKVYAYDSIAKEGIDLKTPMFLQAPVLVRIHIRLPTMFLATAEEDLMYPDWKSISSSAPVNSLVLYSTQPVRLKPNYTLGSTFVRYWDKLPEELRVSIIAENMKAHPARQTPRTQALLTKLYPHCRMTPQIARLAITGFYKHNEFLVQLNSGMPNRYPRAPYNDLIRRLQLSMYIRRSQWEFVQKLSEGKLGFANLKYVSILISWHYPAEDIDETEWDDFVDETRNDCIEFSCDGIVDLVARSAAAITCRAPKYVRGDLAQLTVIQSRIRFGVKGAGSQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CIL7</accession>
    <name>A0A177CIL7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_1195571</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG07353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037718.1">
        <property type="nucleotide sequence ID" value="XM_018181411.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CIL7"/>
    <dbReference type="GeneID" id="28764897"/>
    <dbReference type="InParanoid" id="A0A177CIL7"/>
    <dbReference type="OrthoDB" id="61113at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF47">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="65"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="108"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="142"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="230"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="269"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="49"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAG07353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="361" mass="41453" checksum="1CEE0B0BEF7EDFC6" modified="2016-09-07" version="1">MGVTYDDLIAAMLMNAPDPNEKLPLANRRETIWGTTMPFLVITWAAVFLRFWVRFRVMREPGWDDALVLLAMLLNTAATVLVLISIRYGLGQHFLYLEVSQMMGYVKMFYFENALYITNTAVIKLSLLTQYLRIFKAGTMHWICKALIVIIGAWGFTYGFMAWFPCFPPQAYYDSLKYPNAKCYGFGFVNAKDFIGLFESHTALNMVFDVTVFVTPMVLFTKPNLRMKNLVAMSGIFIVGAVVVFTSIWRLYSIVDNRAATYPYIDFTWWTPISIILSCLEIDLAIMCASMPIFWPVIEESFAAIFVTREVQITEQRRYSFADRGLAYELEHSDTMRRQASVKTQSTSRESLVITREDPGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CIM7</accession>
    <name>A0A177CIM7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Chaperone protein dnaK</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_1116492</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG06718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037083.1">
        <property type="nucleotide sequence ID" value="XM_018175465.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CIM7"/>
    <dbReference type="FunCoup" id="A0A177CIM7">
        <property type="interactions" value="371"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CIM7"/>
    <dbReference type="GeneID" id="28758951"/>
    <dbReference type="InParanoid" id="A0A177CIM7"/>
    <dbReference type="OrthoDB" id="29851at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0101031">
        <property type="term" value="C:protein folding chaperone complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051083">
        <property type="term" value="P:'de novo' cotranslational protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006450">
        <property type="term" value="P:regulation of translational fidelity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006452">
        <property type="term" value="P:translational frameshifting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd10232">
        <property type="entry name" value="ASKHA_NBD_HSP70_ScSsz1p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.30:FF:000009">
        <property type="entry name" value="Heat shock protein Hsp70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000023">
        <property type="entry name" value="Hsp70 chaperone (BiP)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45639:SF32">
        <property type="entry name" value="HEAT SHOCK PROTEIN PDR13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45639">
        <property type="entry name" value="HSC70CB, ISOFORM G-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="478"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="478"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="490"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAG06718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="571" mass="61295" checksum="F199D3386278F0E2" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CIT1</accession>
    <name>A0A177CIT1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">RNA-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CC84DRAFT_1195278</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG06882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037247.1">
        <property type="nucleotide sequence ID" value="XM_018181396.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CIT1"/>
    <dbReference type="STRING" id="1460663.A0A177CIT1"/>
    <dbReference type="GeneID" id="28764882"/>
    <dbReference type="InParanoid" id="A0A177CIT1"/>
    <dbReference type="OrthoDB" id="167718at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12400">
        <property type="entry name" value="RRM_Nop6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000376">
        <property type="entry name" value="Putative RNA binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034228">
        <property type="entry name" value="Nop6_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051106">
        <property type="entry name" value="RNA-bind/splicing_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48028">
        <property type="entry name" value="GLYCINE-RICH RNA-BINDING PROTEIN RZ1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48028:SF4">
        <property type="entry name" value="SC35-LIKE SPLICING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="262"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="364"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="108"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="168"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="187"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="204"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="237"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="364"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAG06882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="456" mass="49695" checksum="E4CED5BF0B43772B" modified="2016-09-07" version="1">MSKSELKDEKKKRKRQEDGAVDVAKKSKKSKKSTDAAAEDPSVGDASKEKKEKKSKQAKKGGSSEDAAPAADGFIAFDDTPMPDAFAGAMNGTISGDERKKEKKKEKKEKSSKKSKDAVEDEAESASVEAPAEKSKSKKDRKSKDSKADADPVESAAAVDSSSEKKDKKSKKGKKEKKAKKSKGVDEVAEPMDVDGAAEETPGKKSKKDKKSKKEKKSKNDPEDASEEVESTPAANDTDDHDEQAEGEANGAADDASQKGPFIVFVGNLPFSTTKEQIEEHFAKLKPFEVRLRTYKDTGKSMGCAFIQFERFDHMQTALLKFHHSVIDDPKKKEGRKINVELSAGGGGNTEARMAKINAKNEKLANERQRNHEKRAEIEGKQAERKAKKESQKGKDGKDGEAGGEGAAEEPENAGIHPARLAMLAQPERPQKQFKPNMGNVPKWKGGPPARGPKRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CJ67</accession>
    <name>A0A177CJ67_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HET-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1175346</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG07565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037930.1">
        <property type="nucleotide sequence ID" value="XM_018180147.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CJ67"/>
    <dbReference type="GeneID" id="28763633"/>
    <dbReference type="InParanoid" id="A0A177CJ67"/>
    <dbReference type="OrthoDB" id="5125733at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF9">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="200"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG07565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="654" mass="73030" checksum="0B33CC05D73684DB" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CJG5</accession>
    <name>A0A177CJG5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1258198</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG06979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037344.1">
        <property type="nucleotide sequence ID" value="XM_018184801.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CJG5"/>
    <dbReference type="STRING" id="1460663.A0A177CJG5"/>
    <dbReference type="GeneID" id="28768287"/>
    <dbReference type="InParanoid" id="A0A177CJG5"/>
    <dbReference type="OrthoDB" id="58379at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38696">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38696:SF1">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG06979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="380" mass="42288" checksum="D417DB05628FBF4D" modified="2016-09-07" version="1">MDRLPDYSNVYFPPPPSSSGTSTNPSAIYYPPPPERAQPSSTSRTNPGPPAGSTHTPSSSISYLPVNISTPPQIPLRQRAPSSPYQPHASVYQGSPLPSPSLLPPAQHVSRPASPAFRTRFAAVSLHAADRLQFLRFPPALYSLLRATIQAVWTRGIQLEKISTQLLELQLKGNPWGVHRDNPDGLGIGALRNVLDRDSEGQAIHAQRLVCALLRALHSEGWVLMQSTDVSQVLWDADTLLFRHQMPAPAPQEWFSVVFQHNRFRFVDAPRGLCLRVLEHLSSQRLEMKFKDHEKVEGCCEVKFTGMMRRGSPYLDPVINAGTLKTRMMFLDLLGVVEESGWTLYASVEQNMRGDGEGMTDTWYCCRPVGWAEGNPVYHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CJU5</accession>
    <name>A0A177CJU5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Acyl-CoA N-acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CC84DRAFT_1163335</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG07100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037465.1">
        <property type="nucleotide sequence ID" value="XM_018178243.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CJU5"/>
    <dbReference type="STRING" id="1460663.A0A177CJU5"/>
    <dbReference type="GeneID" id="28761729"/>
    <dbReference type="InParanoid" id="A0A177CJU5"/>
    <dbReference type="OrthoDB" id="47374at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031415">
        <property type="term" value="C:NatA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007064">
        <property type="term" value="P:mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051556">
        <property type="entry name" value="N-term/lysine_N-AcTrnsfr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42919">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42919:SF8">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="4">
        <location>
            <begin position="47"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="31"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAG07100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="226" mass="24909" checksum="9E052F41F2648FC3" modified="2016-09-07" version="1">MPLARRVQPPASLSEHNHAPTQGRASEPAPKRPPAPLFSTPPLPENVEFAPLTHELIPSFKRILSLTLPVSYPAVFFTESMDEPFHSITLMALWHPAPVNGGAHSSIAQEPRLVGAIRCRILPSANLYISTISLLAPYRSHGIATHLLQKVAAEAVELHGVRCVTAHVWEANEEGLEWYKKRGFDIVGKEDAYYHKLKPQGAILVRKWIGVADLLAHPDAVSVVDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CKT2</accession>
    <name>A0A177CKT2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_657883</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG07478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037843.1">
        <property type="nucleotide sequence ID" value="XM_018187048.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CKT2"/>
    <dbReference type="GeneID" id="28770534"/>
    <dbReference type="InParanoid" id="A0A177CKT2"/>
    <dbReference type="OrthoDB" id="3886018at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008058343" evidence="2">
        <location>
            <begin position="23"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG07478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="459" mass="49500" checksum="0C073E8E49D5B109" modified="2016-09-07" version="1">MKFSNAFLASLLFFGVTPLALDKKRDEHALTTTSSPFATTSTISLVTPDDAGVVEVTGGTHDVLEARARGSRKTTTSRTKKTKTKTGSKTKGKKTKTKCTAAMKKAGKCATKTTCTAAEKKKNGGKCPATCTAAEKKKNGGKCPTCTAAEKKKNGGKCPDKKKRNWEVLSPTKGCRPKRAQKGTTSAKGSKKSGKKTTRDLFSTNSLTLSKRAATFEPAAKTEAGLNAWTKDVWASSPKVLHMPEDSFKPTSFFKSWASLGAGVNFVTVKSLMGCTSVVAVSDEGVYVSHHWQNTVGDASHKDLTPQFDNAFTNPLSGKRRASFKLTPAQHKEATLYMTEADVKKEVDDVFPTSGFEALTDHKSHFTKNVQSMVAVWDGVEGTGDRYRTTGALMQSYVDSLLPGTATKLVKYANPEDARVASGSNDDYHGKVIVSYDSATKKYQVWMPAAKLTEPILKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CL22</accession>
    <name>A0A177CL22_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CC84DRAFT_1144121</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG07529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037894.1">
        <property type="nucleotide sequence ID" value="XM_018176442.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CL22"/>
    <dbReference type="GeneID" id="28759928"/>
    <dbReference type="InParanoid" id="A0A177CL22"/>
    <dbReference type="OrthoDB" id="5667at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17352">
        <property type="entry name" value="MFS_MCT_SLC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF224">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="87"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="142"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="206"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="250"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="288"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="314"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="339"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="380"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="404"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="50"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAG07529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="438" mass="47368" checksum="53B4773B9B0B748B" modified="2016-09-07" version="1">MTEARDLTEPPDQEKVPAESSQQAGVVADGPAQAIVSSEAPDRGWAAWSVVVGGWCAMFVSVGWNNAAGVFQTIYEKDFLQSYSPSAIGWIISLQTFFMFVSAPFTGKAFDSYGPRWIIAIGSFLQVLGVMMMSLSTQYWHFILAQSICTGIGGGAIFFAASNSIATWFKNNRALALGIASAGSATGGVIIPIMVNHIYDDIGFGWALRVVGFVFLGLLTITNVLLKSRLTHVVKKPHPKDFMEPLQEPPFLFLTAACFFFAMAVYQPGTFIALNAQREGIPDHISNYLLSILNASSVIGRVVVGWVADRAGRFNTMIITTFLSALFVLAAWIPAHSTAPFIVFAVLVGFTNGAYVALTSSLVAQISDIKKIGTRNGTNWFMYGIGALIGTPIAGALIQRDSGGYLYMQIFAGLSMFMSGCLFVGSRYVQIGLAWKWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CLM3</accession>
    <name>A0A177CLM3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">xylan 1,4-beta-xylosidase</fullName>
            <ecNumber evidence="11">3.2.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CC84DRAFT_1086169</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>Hydrolysis of (1-&gt;4)-beta-D-xylans, to remove successive D-xylose residues from the non-reducing termini.</text>
            <dbReference type="EC" id="3.2.1.37"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Glycan degradation; xylan degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.37" evidence="11"/>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG07842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038207.1">
        <property type="nucleotide sequence ID" value="XM_018174145.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CLM3"/>
    <dbReference type="STRING" id="1460663.A0A177CLM3"/>
    <dbReference type="GeneID" id="28757631"/>
    <dbReference type="InParanoid" id="A0A177CLM3"/>
    <dbReference type="OrthoDB" id="47059at2759"/>
    <dbReference type="UniPathway" id="UPA00114"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046556">
        <property type="term" value="F:alpha-L-arabinofuranosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009044">
        <property type="term" value="F:xylan 1,4-beta-xylosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031222">
        <property type="term" value="P:arabinan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044993">
        <property type="entry name" value="BXL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42721:SF3">
        <property type="entry name" value="BETA-D-XYLOSIDASE 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42721">
        <property type="entry name" value="SUGAR HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="Beta-D-glucan exohydrolase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0858">Xylan degradation</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008058445" description="xylan 1,4-beta-xylosidase" evidence="12">
        <location>
            <begin position="22"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type III-like" evidence="13">
        <location>
            <begin position="663"/>
            <end position="733"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00026107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OAG07842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="758" mass="81406" checksum="880FB70B8B7E7BA6" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CLX0</accession>
    <name>A0A177CLX0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF1768-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1162276</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038671.1">
        <property type="nucleotide sequence ID" value="XM_018177951.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CLX0"/>
    <dbReference type="STRING" id="1460663.A0A177CLX0"/>
    <dbReference type="GeneID" id="28761437"/>
    <dbReference type="InParanoid" id="A0A177CLX0"/>
    <dbReference type="OrthoDB" id="206452at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd15457">
        <property type="entry name" value="NADAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.40">
        <property type="entry name" value="YbiA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012816">
        <property type="entry name" value="NADAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037238">
        <property type="entry name" value="YbiA-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02464">
        <property type="entry name" value="ribofla_fusion"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08719">
        <property type="entry name" value="NADAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143990">
        <property type="entry name" value="YbiA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADAR" evidence="2">
        <location>
            <begin position="28"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="8"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG08306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="201" mass="23199" checksum="E0D3F9A59D98A98B" modified="2016-09-07" version="1">MAASLRAQSQSQSQSQSQSQSQKTGPVYFWKPQDGHGYLGQWFWSPWTYEGDTYKTAEMWMMVGKARLFGDEDVARDILAADDPREQRALGRKVRNFDEKVWDKNKVRIVEEGNYLKFTISEDAESLRAMLLATGERELVEASPMDRIWGVGFAEKNAGVNRARWGQNLLGRALMNVRRRLSEENTRKEKAKGEEEEQEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CMJ2</accession>
    <name>A0A177CMJ2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Cytosolic Fe-S cluster assembly factor NBP35</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">NBP35</name>
        <name evidence="11" type="ORF">CC84DRAFT_1194680</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NBP35-CFD1 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP1/NBP35 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038881.1">
        <property type="nucleotide sequence ID" value="XM_018181360.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CMJ2"/>
    <dbReference type="FunCoup" id="A0A177CMJ2">
        <property type="interactions" value="575"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CMJ2"/>
    <dbReference type="GeneID" id="28764846"/>
    <dbReference type="InParanoid" id="A0A177CMJ2"/>
    <dbReference type="OrthoDB" id="1741334at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904564">
        <property type="term" value="C:cytosolic [4Fe-4S] assembly scaffold complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140663">
        <property type="term" value="F:ATP-dependent FeS chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd02037">
        <property type="entry name" value="Mrp_NBP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000427">
        <property type="entry name" value="Cytosolic Fe-S cluster assembly factor NUBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02040">
        <property type="entry name" value="Mrp_NBP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03038">
        <property type="entry name" value="NUBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019591">
        <property type="entry name" value="Mrp/NBP35_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028601">
        <property type="entry name" value="NUBP1/Nbp35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033756">
        <property type="entry name" value="YlxH/NBP35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23264:SF35">
        <property type="entry name" value="CYTOSOLIC FE-S CLUSTER ASSEMBLY FACTOR NUBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23264">
        <property type="entry name" value="NUCLEOTIDE-BINDING PROTEIN NBP35 YEAST -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10609">
        <property type="entry name" value="ParA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 10" id="KW-0408">Iron</keyword>
    <keyword evidence="9 10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="10">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="84"/>
            <end position="91"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="257"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>ligand shared with heterodimeric partner</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="260"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>ligand shared with heterodimeric partner</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OAG08516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="340" mass="36393" checksum="F03FA8B46A0715F1" modified="2016-09-07" version="1">MAPSLEEPVQIDLNAPLKAAPKLVAPEPEHCPGPESEQAGVADNCAGCPNQKICASAPKGPDPDIPVITERLASVRHKILVLSGKGGVGKSTFSTMLSHAFASNPNLTVGLMDTDICGPSIPKMMGVEEETIHVSAEGWEPVWVSENLGVMSVQFMLPGRDDAVIWRGAKKNGLIKKFLMEVRWGEMDMLIVDTPPGTSDEHLSVNSFLKSSGVDGAVLVSTPQEVSLLDVRKEIDFCRKAKIPILGIVENMSGFVCPGCKHESQIFRASTGGAKRLAADEKIPFLGAVPLDPRIGMACDFGESFLDAYPESPACKAIRHVVRRVAEEIGMQGDVLEGDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CML7</accession>
    <name>A0A177CML7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">SIR2 family histone deacetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CC84DRAFT_1185529</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sirtuin family. Class I subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039140.1">
        <property type="nucleotide sequence ID" value="XM_018180809.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CML7"/>
    <dbReference type="STRING" id="1460663.A0A177CML7"/>
    <dbReference type="GeneID" id="28764295"/>
    <dbReference type="InParanoid" id="A0A177CML7"/>
    <dbReference type="OrthoDB" id="424302at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017136">
        <property type="term" value="F:histone deacetylase activity, NAD-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1600.10">
        <property type="entry name" value="SIR2/SIRT2 'Small Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050134">
        <property type="entry name" value="NAD-dep_sirtuin_deacylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026591">
        <property type="entry name" value="Sirtuin_cat_small_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085:SF10">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="5">
        <location>
            <begin position="1"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="118"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAG08775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="282" mass="30957" checksum="731D0F224BFEB8EC" modified="2016-09-07" version="1">MLASFTAHLNSSNRILVLIGAGLSASSGIPTYRSASGFWRTFSDQQLAKKSAFEEDPILVWQFYNYRRQQAKAALPNPAHHALAELAARRPELFSVNQNVDELCQRAGHPMGQIVDLHGSLFRVKCFDDACGYEEENHEIPIIPQLSVTEPPGVLDSADYNSAQSGVSIEDLPHCPKCKVGLLRPATVWFGENLPEAKVHQVDEWLQDGKVDLMLVIGTSAMVWPAAGYIGRARNAGARVAFFNMMEKAAGVARPEESDWMFLGDAAELVPKAFEGFLGVDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CNA5</accession>
    <name>A0A177CNA5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ARM repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1257190</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038674.1">
        <property type="nucleotide sequence ID" value="XM_018184706.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CNA5"/>
    <dbReference type="STRING" id="1460663.A0A177CNA5"/>
    <dbReference type="GeneID" id="28768192"/>
    <dbReference type="InParanoid" id="A0A177CNA5"/>
    <dbReference type="OrthoDB" id="26149at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040144">
        <property type="entry name" value="RAP1GDS1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10957">
        <property type="entry name" value="RAP1 GTPASE-GDP DISSOCIATION STIMULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG08309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="640" mass="70255" checksum="632D1AA7EDE02F97" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CNK4</accession>
    <name>A0A177CNK4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_1086894</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038702.1">
        <property type="nucleotide sequence ID" value="XM_018174176.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CNK4"/>
    <dbReference type="GeneID" id="28757662"/>
    <dbReference type="InParanoid" id="A0A177CNK4"/>
    <dbReference type="OrthoDB" id="5345571at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057082">
        <property type="entry name" value="PH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057081">
        <property type="entry name" value="PH_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23076">
        <property type="entry name" value="PH_FT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23074">
        <property type="entry name" value="PH_FT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="312"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="3">
        <location>
            <begin position="432"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAG08337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="546" mass="62659" checksum="1C0023AE46DD6AB3" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CP49</accession>
    <name>A0A177CP49_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxymethylenebutenolidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1257409</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038934.1">
        <property type="nucleotide sequence ID" value="XM_018184729.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CP49"/>
    <dbReference type="STRING" id="1460663.A0A177CP49"/>
    <dbReference type="GeneID" id="28768215"/>
    <dbReference type="InParanoid" id="A0A177CP49"/>
    <dbReference type="OrthoDB" id="5440at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030638">
        <property type="term" value="P:polyketide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009959">
        <property type="entry name" value="Cyclase_SnoaL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38436:SF3">
        <property type="entry name" value="CARBOXYMETHYLENEBUTENOLIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38436">
        <property type="entry name" value="POLYKETIDE CYCLASE SNOAL-LIKE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG08569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="409" mass="45852" checksum="FF4C0629529C0C06" modified="2016-09-07" version="1">MFNDITQPPPPLPTAALRTLSKGVSILSPLTRRGHGPGVILLVPDSDASTKIIEGVPSHLVKWAEEGYAVVEIQQQALQNNTKDALSQAIDALKRLETCTPKEKIGVVAYDPTCWSLAAETVNSVSEVAATVVYADIAQHNSIAVSRSPSIYHLAGKGSDRPLRSENLTVYYYPEVQSYTFAIPFQKTFHYGQEALSHTRSLTHLKKRMDGPWFDLELIWEEHTYYEFADRSVEHTMSTMVQEPYVNHVPTLTGGVGRASLTNFYAHNFIFNNSADTSLELTSRSIAIDRVIDEFIFTFTHDRELDWLLPGVPPTNLKVEVPFNAVVNIRGDRLYHEHISWDQGTVLRQLGLLPEYLPFPYALPDGMTPAPGKRIEYRVPVAGTDAADKLRDRNSVPSNQMFDFKIREV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CP69</accession>
    <name>A0A177CP69_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">3-phytase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1116079</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG09086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039451.1">
        <property type="nucleotide sequence ID" value="XM_018175449.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CP69"/>
    <dbReference type="STRING" id="1460663.A0A177CP69"/>
    <dbReference type="GeneID" id="28758935"/>
    <dbReference type="InParanoid" id="A0A177CP69"/>
    <dbReference type="OrthoDB" id="6509975at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07061">
        <property type="entry name" value="HP_HAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20963">
        <property type="entry name" value="MULTIPLE INOSITOL POLYPHOSPHATE PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20963:SF43">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_7G01240)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008058429" evidence="2">
        <location>
            <begin position="21"/>
            <end position="543"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG09086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="543" mass="61451" checksum="92D82EFBEF9718B2" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CPC0</accession>
    <name>A0A177CPC0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_1160543</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG09373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039738.1">
        <property type="nucleotide sequence ID" value="XM_018177525.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CPC0"/>
    <dbReference type="GeneID" id="28761011"/>
    <dbReference type="InParanoid" id="A0A177CPC0"/>
    <dbReference type="OrthoDB" id="419598at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051609">
        <property type="entry name" value="NmrA/Isoflavone_reductase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706:SF5">
        <property type="entry name" value="ISOFLAVONE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706">
        <property type="entry name" value="NMRA-LIKE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008058424" evidence="3">
        <location>
            <begin position="20"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAG09373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="340" mass="37610" checksum="7F31F8549C73EE07" modified="2016-09-07" version="1">MSIMRVAVAGTCGLALILARQIHESTSHQLVILSRSSQPGLQSQGYQCQVVDYNDPSSIQHSLLGVDTIISTVTGNAQLRLIEAAVACRVRRFVPAEFEGQPSVRTQNGLLDRGRAAALALLQHYRGYIQSTVFVCGVFYERFSVNGMVSLRIGVNTGYGNEGDYVADPRNMTAVAPVYDSSQNLSVVCLTSVYDVARFVVRSLDMTSWPQEMTMCGERMTVQSLIETIQSCRGRQFYPVEWQNPANLQYQMTMAQIAGDTSKQRKLATLIETSENRYQFASPAYLNSLFPEIVPMSFRNWFSSTSSVSSLKATRTYMLQTTGPRCPSSATYQLDGGVHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CQ77</accession>
    <name>A0A177CQ77_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1075192</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG09674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040039.1">
        <property type="nucleotide sequence ID" value="XM_018173709.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CQ77"/>
    <dbReference type="STRING" id="1460663.A0A177CQ77"/>
    <dbReference type="GeneID" id="28757195"/>
    <dbReference type="InParanoid" id="A0A177CQ77"/>
    <dbReference type="OrthoDB" id="433474at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049492">
        <property type="entry name" value="BD-FAE-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF33">
        <property type="entry name" value="KYNURENINE FORMAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20434">
        <property type="entry name" value="BD-FAE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BD-FAE-like" evidence="2">
        <location>
            <begin position="60"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG09674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="299" mass="31856" checksum="D00A2BE498EB9303" modified="2016-09-07" version="1" fragment="single">AALGAEITGLAVFRPTTDAITPERVNELMAQMHVDVPAGGEDISYGASPAQVLRYWKPKPKGEGKAPPLIVFIHGGSWRVGTYLDSLGSRKVEWLVGSGYAFASINYTLIPAVSVKQQVQECADAISFFTQRAPFFGFDGDSIVLMGHSSGAHVAALLGTDARYLENVGVGTDKIRGVVCIDGSNFNAAAELLDSPGPVAENMLAGLGDDVGVLRDMSPTYHARGPNAAAFLLLQAQRHGDIRQAVEFEASLLAAGTKVEVRVFEGEFFEGHVAMLIRLGDEGYPATGVVGKWLRREVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CQP8</accession>
    <name>A0A177CQP8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MATE efflux family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_453995</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG09835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040200.1">
        <property type="nucleotide sequence ID" value="XM_018186338.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CQP8"/>
    <dbReference type="FunCoup" id="A0A177CQP8">
        <property type="interactions" value="117"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CQP8"/>
    <dbReference type="GeneID" id="28769824"/>
    <dbReference type="InParanoid" id="A0A177CQP8"/>
    <dbReference type="OrthoDB" id="2126698at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990961">
        <property type="term" value="P:xenobiotic detoxification by transmembrane export across the plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13132">
        <property type="entry name" value="MATE_eukaryotic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045069">
        <property type="entry name" value="MATE_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00797">
        <property type="entry name" value="matE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11206">
        <property type="entry name" value="MULTIDRUG RESISTANCE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="301"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="364"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="392"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="439"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="472"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="515"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="551"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="589"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="616"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="38"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="122"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="40"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="61"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="84"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAG09835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="660" mass="72559" checksum="0420154C0034CAB0" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CRR2</accession>
    <name>A0A177CRR2_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phosphotransferase</fullName>
            <ecNumber evidence="6">2.7.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CC84DRAFT_1112291</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the hexokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.-" evidence="6"/>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040578.1">
        <property type="nucleotide sequence ID" value="XM_018175313.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CRR2"/>
    <dbReference type="STRING" id="1460663.A0A177CRR2"/>
    <dbReference type="GeneID" id="28758799"/>
    <dbReference type="InParanoid" id="A0A177CRR2"/>
    <dbReference type="OrthoDB" id="419537at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00180"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005536">
        <property type="term" value="F:D-glucose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008865">
        <property type="term" value="F:fructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004340">
        <property type="term" value="F:glucokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019158">
        <property type="term" value="F:mannokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001678">
        <property type="term" value="P:intracellular glucose homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006013">
        <property type="term" value="P:mannose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd24000">
        <property type="entry name" value="ASKHA_NBD_HK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.367.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001312">
        <property type="entry name" value="Hexokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022673">
        <property type="entry name" value="Hexokinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022672">
        <property type="entry name" value="Hexokinase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443">
        <property type="entry name" value="HEXOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443:SF29">
        <property type="entry name" value="PHOSPHOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00349">
        <property type="entry name" value="Hexokinase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03727">
        <property type="entry name" value="Hexokinase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00475">
        <property type="entry name" value="HEXOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51748">
        <property type="entry name" value="HEXOKINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="4 6" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Hexokinase N-terminal" evidence="8">
        <location>
            <begin position="20"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="Hexokinase C-terminal" evidence="9">
        <location>
            <begin position="258"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="199"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAG10213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="527" mass="57121" checksum="2B9C375A26B20CEA" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CRS2</accession>
    <name>A0A177CRS2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SET domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1161199</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040588.1">
        <property type="nucleotide sequence ID" value="XM_018177674.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CRS2"/>
    <dbReference type="STRING" id="1460663.A0A177CRS2"/>
    <dbReference type="GeneID" id="28761160"/>
    <dbReference type="InParanoid" id="A0A177CRS2"/>
    <dbReference type="OrthoDB" id="10261904at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053105">
        <property type="entry name" value="Class_V-like_SAM-MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47250">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SET-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47250:SF3">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SET-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SET" evidence="2">
        <location>
            <begin position="468"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG10223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="600" mass="68455" checksum="8A91758C67B40A31" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CSM6</accession>
    <name>A0A177CSM6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative gibberellin 3-beta hydroxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CC84DRAFT_456015</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG09890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040255.1">
        <property type="nucleotide sequence ID" value="XM_018186346.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CSM6"/>
    <dbReference type="STRING" id="1460663.A0A177CSM6"/>
    <dbReference type="GeneID" id="28769832"/>
    <dbReference type="InParanoid" id="A0A177CSM6"/>
    <dbReference type="OrthoDB" id="288590at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044283">
        <property type="term" value="P:small molecule biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10209:SF867">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10209">
        <property type="entry name" value="OXIDOREDUCTASE, 2OG-FE II OXYGENASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00682">
        <property type="entry name" value="IPNSYNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="6">
        <location>
            <begin position="208"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAG09890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="350" mass="39927" checksum="4A9233DE62596608" modified="2016-09-07" version="1">MSTTTVETVPLPALSLTLQNGQKIRYHSDISIEADEIPVIDISDIYSDNLQARKAVAEKVREAAHRIGFFYIINHGIDPEHAENTFQQAKRFFAQPEKKKMEVCTDLVTEYFGYFPMAKYNRNGKKEKDLMEAYNWGYSPKYDPEVASGKEPDVDYVKLLWPVELPGFKETLYEHHSQLLTLARRLTKTFALALHLDEDYFAEYIKTPAAGMRITHYPSQEASPSDQLGIGAHTDFECFTFVTQDEHAGLEVLSKSGYWIKAKPIPGSIVVNIADCFMRQTNDFFVSTVHRVVNKAGAERYSCPFFFGFQQDMKLEPVPTCVSDSNPMKYPIVSSGEYLRWRAEQAKKVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CU41</accession>
    <name>A0A177CU41_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">5',5'''-P-1,P-4-tetraphosphate phosphorylase 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1184366</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040644.1">
        <property type="nucleotide sequence ID" value="XM_018180745.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CU41"/>
    <dbReference type="FunCoup" id="A0A177CU41">
        <property type="interactions" value="198"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CU41"/>
    <dbReference type="GeneID" id="28764231"/>
    <dbReference type="InParanoid" id="A0A177CU41"/>
    <dbReference type="OrthoDB" id="10267950at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003877">
        <property type="term" value="F:ATP:ADP adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009163">
        <property type="entry name" value="Ap4A_phos1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043171">
        <property type="entry name" value="Ap4A_phos1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045759">
        <property type="entry name" value="Ap4A_phos1/2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019200">
        <property type="entry name" value="ATP_adenylylTrfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38420:SF3">
        <property type="entry name" value="5',5'''-P-1,P-4-TETRAPHOSPHATE PHOSPHORYLASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38420">
        <property type="entry name" value="AP-4-A PHOSPHORYLASE II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19327">
        <property type="entry name" value="Ap4A_phos_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09830">
        <property type="entry name" value="ATP_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ap4A phosphorylase 1/2 N-terminal" evidence="2">
        <location>
            <begin position="8"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="ATP adenylyltransferase C-terminal" evidence="1">
        <location>
            <begin position="203"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG10279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="342" mass="38151" checksum="BDCF4AC7BAFA24D5" modified="2016-09-07" version="1">MNKMLGLSEALPQLVESKFTSARASQALLFSPTELCIIRTAAGIPFQLRYCPSLARKPEPRKDPTPKRKIDPFENPPAELFIANVPTTNPSHFLVLNKFPVIKSHFILATKPNKQQTHALEEDDLKAAYACLKAWQTRDNRCRLFAFFNSGDHSGASQPHRHLQFLPVDSMHEGEQSAGWDVLLDSILTNGTEDASTSVVQHPKLPFSHFACRFTSEPSGTQLLSTYNRLYREAKQAIDGYISAHPGHLSLHESAHGDLPISYNLAMSTQGMAIVPRRNEGHMMRRDDGTDIGFVQLNGTVLGGTLMVKFPEEWDTLRQQPEKLDAILEAIGIPRTTETTKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CUH4</accession>
    <name>A0A177CUH4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">(4-O-methyl)-D-glucuronate--lignin esterase</fullName>
            <ecNumber evidence="7">3.1.1.117</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CC84DRAFT_1084406</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 4-O-methyl-alpha-D-glucuronosyl ester derivative + H2O = 4-O-methyl-alpha-D-glucuronate derivative + an alcohol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:67452"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:171667"/>
            <dbReference type="ChEBI" id="CHEBI:171668"/>
            <dbReference type="EC" id="3.1.1.117"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:67453"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the carbohydrate esterase 15 (CE15) family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.117" evidence="7"/>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041216.1">
        <property type="nucleotide sequence ID" value="XM_018174052.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CUH4"/>
    <dbReference type="STRING" id="1460663.A0A177CUH4"/>
    <dbReference type="GeneID" id="28757538"/>
    <dbReference type="InParanoid" id="A0A177CUH4"/>
    <dbReference type="OrthoDB" id="3781271at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046274">
        <property type="term" value="P:lignin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054579">
        <property type="entry name" value="GCE-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22244">
        <property type="entry name" value="GCE_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0439">Lignin degradation</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="3 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008058681" description="(4-O-methyl)-D-glucuronate--lignin esterase" evidence="8">
        <location>
            <begin position="18"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="domain" description="4-O-methyl-glucuronoyl methylesterase-like" evidence="9">
        <location>
            <begin position="117"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00026105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF22244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAG10851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="404" mass="42925" checksum="212B50C5DA2F8068" modified="2016-09-07" version="1">MHVTYLAFALCAATVSGAPASGTTFLQLLDLLPRQSNVTCPQTPSPMPKAADLPAVKTMPDPFLYLDGKTKVKSKDEWYQCRQPEILKLLQEYQYGYYPDHSQETVTASRSGTKLDVTIAAGGKSATISATLNLPSGSGPFPVIIAIGGIDNNSYLKAGIAVVTFDYGKVAADSNSKTGSFWTLYNGKDIGVLTAWAWGFHRVLDGIELKVPEIDAKKSGVTGCSRLGKAALAAGLFDKRIAVTMPMCSGVQGAGPYRYSLSGQGENLENSKSGAGWWTSSGISQFVNHATQLPYDAHTIVAAIAPRAVILEQGASDQFTDSKGTATVTFPAAKAVYKWLGAGDQLGMSIPKGGHCDMGGYADVLPFVQKVLQGKTTSRNYDDLGSWKAMPEAYPWATSLPAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CUI5</accession>
    <name>A0A177CUI5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SGT1 family protein-like protein Sgt1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1158784</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG11183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041548.1">
        <property type="nucleotide sequence ID" value="XM_018177069.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CUI5"/>
    <dbReference type="STRING" id="1460663.A0A177CUI5"/>
    <dbReference type="GeneID" id="28760555"/>
    <dbReference type="InParanoid" id="A0A177CUI5"/>
    <dbReference type="OrthoDB" id="27237at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010770">
        <property type="entry name" value="Ecd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13060:SF0">
        <property type="entry name" value="PROTEIN ECDYSONELESS HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13060">
        <property type="entry name" value="SGT1 PROTEIN HSGT1 SUPPRESSOR OF GCR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07093">
        <property type="entry name" value="SGT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="418"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="526"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="612"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="454"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="538"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="569"/>
            <end position="581"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG11183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="634" mass="71561" checksum="203ADF5DFCFD74FD" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CVR2</accession>
    <name>A0A177CVR2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CC84DRAFT_1080232</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the polysaccharide monooxygenase AA14 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG11613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041978.1">
        <property type="nucleotide sequence ID" value="XM_018173884.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CVR2"/>
    <dbReference type="STRING" id="1460663.A0A177CVR2"/>
    <dbReference type="GeneID" id="28757370"/>
    <dbReference type="InParanoid" id="A0A177CVR2"/>
    <dbReference type="OrthoDB" id="2019572at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054497">
        <property type="entry name" value="LPMO_AA14"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22810">
        <property type="entry name" value="LPMO_AA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0186">Copper</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00046340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OAG11613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="267" mass="29457" checksum="D5EF3C48B34A440C" modified="2016-09-07" version="1">MYCKAGPDPNTENLNTNTAVNPLYNLTKEQWWFQHDRGCDLVPPPTGEFLELPANGNFTVELAHNRAQTTLSYDGKFASDWIDGKDHPDDWNSWEGPGSACLDDGAMHTYNETNAAGTAWAISYESDMAKVTMENLVVFSTLQHTPWKRIATYQVPDLPACPEDGCTCAWLWVPDGCGQPNMYMQPYKCTVTNAKSTTPVAKAQAPVYCADDASKCVQGAKQMIAWNQLDGNNIETGDHISPGYNEKCGWKNGAQADIFGRPVADNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CXA3</accession>
    <name>A0A177CXA3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1159012</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG11490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041855.1">
        <property type="nucleotide sequence ID" value="XM_018177114.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CXA3"/>
    <dbReference type="GeneID" id="28760600"/>
    <dbReference type="InParanoid" id="A0A177CXA3"/>
    <dbReference type="OrthoDB" id="3799620at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG11490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="229" mass="24863" checksum="D75744722764D590" modified="2016-09-07" version="1">MGRTCLMDEYENNYDAIVPRGKEKDDFVDEDFGALGRAIGLPEACALKVLELDVHLFRTYDHSKDWEASGSRFVVNFGGNGEGEGGDEDGDEDDDFASEDSYDEGYWNKYGTNLSHPEDVTGCVADSNFLKNLGTFWEKVKIKYTPTYMEGYWGDGDPVEANVLAVLIIEESLAETAKELVGGEGWAVRDSLEDECVSSGVGVGCREEDGGGEDGTSGACWAAQLPGAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CXI0</accession>
    <name>A0A177CXI0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CC84DRAFT_1224782</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG11560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041925.1">
        <property type="nucleotide sequence ID" value="XM_018183548.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CXI0"/>
    <dbReference type="STRING" id="1460663.A0A177CXI0"/>
    <dbReference type="GeneID" id="28767034"/>
    <dbReference type="InParanoid" id="A0A177CXI0"/>
    <dbReference type="OrthoDB" id="3945418at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11062">
        <property type="entry name" value="CYP58-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF157">
        <property type="entry name" value="N-ACETYLTRYPTOPHAN 6-HYDROXYLASE IVOC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7 8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="296"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="441"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAG11560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="516" mass="58483" checksum="16135785390B0892" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CXL6</accession>
    <name>A0A177CXL6_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Transcription regulator Rua1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_62242</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG11941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042306.1">
        <property type="nucleotide sequence ID" value="XM_018186923.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CXL6"/>
    <dbReference type="GeneID" id="28770409"/>
    <dbReference type="InParanoid" id="A0A177CXL6"/>
    <dbReference type="OrthoDB" id="5595379at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028012">
        <property type="entry name" value="Rua1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28125">
        <property type="entry name" value="MEIOTIC EXPRESSION UP-REGULATED PROTEIN 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28125:SF3">
        <property type="entry name" value="TRANSCRIPTION REGULATOR RUA1 C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14616">
        <property type="entry name" value="Rua1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription regulator Rua1 C-terminal" evidence="2">
        <location>
            <begin position="449"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="246"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="413"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="552"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="615"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="283"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="303"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="552"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="569"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="581"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="615"/>
            <end position="647"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG11941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="704" mass="77630" checksum="1E9C2CF1347EBC1B" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CXX1</accession>
    <name>A0A177CXX1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ap4A phosphorylase II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1134997</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042748.1">
        <property type="nucleotide sequence ID" value="XM_018176041.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CXX1"/>
    <dbReference type="STRING" id="1460663.A0A177CXX1"/>
    <dbReference type="GeneID" id="28759527"/>
    <dbReference type="InParanoid" id="A0A177CXX1"/>
    <dbReference type="OrthoDB" id="10267950at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003877">
        <property type="term" value="F:ATP:ADP adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009163">
        <property type="entry name" value="Ap4A_phos1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043171">
        <property type="entry name" value="Ap4A_phos1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045759">
        <property type="entry name" value="Ap4A_phos1/2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019200">
        <property type="entry name" value="ATP_adenylylTrfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38420">
        <property type="entry name" value="AP-4-A PHOSPHORYLASE II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38420:SF1">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_5G14690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19327">
        <property type="entry name" value="Ap4A_phos_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09830">
        <property type="entry name" value="ATP_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ap4A phosphorylase 1/2 N-terminal" evidence="2">
        <location>
            <begin position="7"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="ATP adenylyltransferase C-terminal" evidence="1">
        <location>
            <begin position="177"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG12383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="278" mass="31386" checksum="7644A762CB23BA07" modified="2016-09-07" version="1">MGSIADLEQQALSQFDRLVEAGELLWTEVKARHVKSTPFNFQFRVASSLAKKPQSATRHQKKVSNAFDDDNPDFSLGLVGPSHKLILNKFCVVRPQFVIHTVDFEPQQTPLSVADLSALWHVLGNLQSEHFAIFNCGVDAGASVGHKHMQVLPHPGREDFEMFPDSVELGEDIYIHPDVPFQHAVQKLPQEADAYALVKIYRSLRNRLALGNQAPHNVVLTKRWLMVIPRRVGRIADGEMAANSAVMVGIVWMTKENEYELWTRDDPMKFLPEFGVPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CYD2</accession>
    <name>A0A177CYD2_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">60S ribosomal protein L8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CC84DRAFT_1192499</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL8 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042611.1">
        <property type="nucleotide sequence ID" value="XM_018181250.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CYD2"/>
    <dbReference type="FunCoup" id="A0A177CYD2">
        <property type="interactions" value="1104"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CYD2"/>
    <dbReference type="GeneID" id="28764736"/>
    <dbReference type="InParanoid" id="A0A177CYD2"/>
    <dbReference type="OrthoDB" id="29563at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030684">
        <property type="term" value="C:preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.30:FF:000003">
        <property type="entry name" value="60S ribosomal protein L7a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050257">
        <property type="entry name" value="eL8/uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004037">
        <property type="entry name" value="Ribosomal_eL8-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_eL8/eL30/eS12/Gad45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018492">
        <property type="entry name" value="Ribosomal_eL8/Nhp2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001921">
        <property type="entry name" value="Ribosomal_eL8_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23105">
        <property type="entry name" value="RIBOSOMAL PROTEIN L7AE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00881">
        <property type="entry name" value="L7ARS6FAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00882">
        <property type="entry name" value="RIBOSOMALL7A"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01082">
        <property type="entry name" value="RIBOSOMAL_L7AE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal protein eL8/eL30/eS12/Gadd45" evidence="6">
        <location>
            <begin position="121"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="8"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAG12246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="261" mass="29083" checksum="1225AECD0CCB9025" modified="2016-09-07" version="1">MAPKAKKAAPAPFPQGKAGTKKTAKNPLLEKRPKNFGIGQDIQPQRNLSRMVRWPAYVRLQRQKKILNLRLKVPPSIAQFQHVLDRNTATQAFKLLNKYRPETKAEKKERLTKEATAVSEGKKKEDVSKKPYTAKFGLNHVVGLIENKKASLVLIANDVDPIELVVFLPALCRKMGVPYAIVKGKARLGTVVHQKTAAVLALTEVRSEDKSELSKLSSAIQDGYLEKHKDTIRHWGGGIMGAKANARMDKRRKALESAIKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CYE5</accession>
    <name>A0A177CYE5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HET-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1080657</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG11739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042104.1">
        <property type="nucleotide sequence ID" value="XM_018173902.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CYE5"/>
    <dbReference type="STRING" id="1460663.A0A177CYE5"/>
    <dbReference type="GeneID" id="28757388"/>
    <dbReference type="InParanoid" id="A0A177CYE5"/>
    <dbReference type="OrthoDB" id="5428863at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF1">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="2">
        <location>
            <begin position="98"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG11739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="342" mass="38384" checksum="AAFECEFDA522BB84" modified="2016-09-07" version="1" fragment="single">MDQSHFVGRLTFAQEESNSGHDADLTSPHLGISTKPAPDAKLTISSEPQVDFDLFRTWNERCQQHDDCIPDDTSDLERLKVIDCETRTVQLAPEKCPFVALSYLWGPQEDFAPQPLPAEQTRTIEDAITVTLRLGLRYLWVDRYCIEQTSIMDKTLQIKQMGQIYASAHLTIIAAAGTDPTHGLPGVSQPRQVNETVAEQVGPVTLVQLNTPTASDFQQSMWATRAWTFQEGILSKRRLIFTPQAVLYICSTDYLHDLSPGYSSGINFELVALAEFISCARLPREFQSSAGSSRFKEAMRYVTAYSRRNMRMSSDALNAIIGILNYISTDKTEPVYHLWGVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CZ93</accession>
    <name>A0A177CZ93_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_71191</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042525.1">
        <property type="nucleotide sequence ID" value="XM_018187131.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CZ93"/>
    <dbReference type="GeneID" id="28770617"/>
    <dbReference type="InParanoid" id="A0A177CZ93"/>
    <dbReference type="OrthoDB" id="3799266at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="204"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG12160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="246" mass="28121" checksum="22802B27AF01E869" modified="2016-09-07" version="1">MAHSTPRYDSYRPDGQTSRLNTDLRRGGAWTPGLSTASHAQTNSRTVRHDTPTIPQSIEVNEDDRPKVPQIYHREIDRLIGRTVRAYRLVINYQRDCSGGHRWMPEHIEMIHEAGKKIQTDREALESLRLGLVRGDDAAVVGQVRDAAHALRDYCEEIQELVQVHERVPVFNGKKLEWCGQGRSVRMQFRDALGERRDMGGIQRVGGHVRHEPPVKQLDASPRTQPDRYDGSGRRGFFASDTWRPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CZA8</accession>
    <name>A0A177CZA8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1108439</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ornithine cyclodeaminase/mu-crystallin family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042612.1">
        <property type="nucleotide sequence ID" value="XM_018175200.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CZA8"/>
    <dbReference type="FunCoup" id="A0A177CZA8">
        <property type="interactions" value="7"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CZA8"/>
    <dbReference type="GeneID" id="28758686"/>
    <dbReference type="InParanoid" id="A0A177CZA8"/>
    <dbReference type="OrthoDB" id="41492at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000577">
        <property type="entry name" value="Proline utilization protein PrnX, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1780.10">
        <property type="entry name" value="ornithine cyclodeaminase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003462">
        <property type="entry name" value="ODC_Mu_crystall"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023401">
        <property type="entry name" value="ODC_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13812">
        <property type="entry name" value="KETIMINE REDUCTASE MU-CRYSTALLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13812:SF19">
        <property type="entry name" value="KETIMINE REDUCTASE MU-CRYSTALLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG12247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="468" mass="50600" checksum="02118AB19BDF8B6F" modified="2016-09-07" version="1">MPLTILTDSEVRTLLLGLKKQDILDLQQSLADALHYYSNSTDQDHNGCSSSYQPLRTSLKRSDGQTTLFMPASSNDGLGVKIVTLSEPDSAKGSLSSNGSTSSARGSLASFDSLSLSAASTSSSTTAVSVPSDSLTSKDSTTPKGLLTLLDRSGGPRALINAEEITAFRTALASTMLFKKRANVHDVVVFGAGKQAYWHIRLALLLRGPEIHHLNVINRSFERATNLIQSLFKGPDGAGTDLSRPKVQIITPAAQEYERLLKATIRASSVIFCTTPSLVPLFPAGHLTNPEGRKKGRYVAAIGSYKPHMLELHPDILKQNVAPDHNRHHHKHALQGGAVIVDSVEACLKEAGEVIQAGLTGNEVVEIGELIMLRRDADRKRQECVTRKSMEGMDDTGVEIGECEQRKKKRKGKKEKEEDAGDRGLIEWLQKGNVIYKSVGLGLMDVVVGSDLVALADSRGIGTQIDNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177D018</accession>
    <name>A0A177D018_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Zf-ZPR1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CC84DRAFT_1212218</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ZPR1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018043073.1">
        <property type="nucleotide sequence ID" value="XM_018182434.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177D018"/>
    <dbReference type="FunCoup" id="A0A177D018">
        <property type="interactions" value="986"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177D018"/>
    <dbReference type="GeneID" id="28765920"/>
    <dbReference type="InParanoid" id="A0A177D018"/>
    <dbReference type="OrthoDB" id="308464at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.420:FF:000002">
        <property type="entry name" value="Zinc finger protein ZPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.1040:FF:000001">
        <property type="entry name" value="Zinc finger protein ZPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.1040:FF:000003">
        <property type="entry name" value="Zinc finger protein zpr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1040">
        <property type="entry name" value="ZPR1, A/B domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.420">
        <property type="entry name" value="ZPR1, zinc finger domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004457">
        <property type="entry name" value="Znf_ZPR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040141">
        <property type="entry name" value="ZPR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042451">
        <property type="entry name" value="ZPR1_A/B_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056180">
        <property type="entry name" value="ZPR1_jr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042452">
        <property type="entry name" value="ZPR1_Znf1/2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00310">
        <property type="entry name" value="ZPR1_znf"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10876">
        <property type="entry name" value="ZINC FINGER PROTEIN ZPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10876:SF0">
        <property type="entry name" value="ZINC FINGER PROTEIN ZPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22794">
        <property type="entry name" value="jr-ZPR1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03367">
        <property type="entry name" value="Zn_ribbon_ZPR1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00709">
        <property type="entry name" value="Zpr1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Zinc finger ZPR1-type" evidence="6">
        <location>
            <begin position="31"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="Zinc finger ZPR1-type" evidence="6">
        <location>
            <begin position="256"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="423"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAG12708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="473" mass="51914" checksum="19828C9675909E1E" modified="2016-09-07" version="1">MAQQSLAKDLFEDMGRKVAEASARDDDVDGTRVASTRLLLTKIPFFREIVLMSSACPECGWKNAEVQPAGEIQQRGIKITLKVESAADLSRQIVKSDTAVFRVEDIDLEIPPGRGQLTNVEGVLSMVAEDLEQKQNERKEVVPEVYEKIQGVIETLKEMAAGKKTSFKITVDDPAGNSSIEPSTQDTSTKYFRHEYPRSPDQNAALGLGSSGDAPPTEIRPEYHADQMYPRMPQGPMVNNVDEDEIQENQVYSFPASCPGCTNPCTTNMKMVNIPHFKQVVLMSTVCEHCGYRSNEVKTGGEVPEKGRRITVSVENKEDLSRDILKAESCALSCPELNLSVEAGTLGGRFTTIEGLLTQVRDDLRSSIFDIGEGGDSMDSGTKTKWDDFFGQLSSAINGEVKFTCILSDPLASSYVQSFAAPEPDSQMKVEDYERTEEEEEELGLRDMNTEAYADDQPTTNGAATNGEVVNGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177D0H0</accession>
    <name>A0A177D0H0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glycerol-3-phosphate phosphatase 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_133727</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042995.1">
        <property type="nucleotide sequence ID" value="XM_018185382.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177D0H0"/>
    <dbReference type="FunCoup" id="A0A177D0H0">
        <property type="interactions" value="385"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177D0H0"/>
    <dbReference type="GeneID" id="28768868"/>
    <dbReference type="InParanoid" id="A0A177D0H0"/>
    <dbReference type="OrthoDB" id="40579at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050308">
        <property type="term" value="F:sugar-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07527">
        <property type="entry name" value="HAD_ScGPP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000412">
        <property type="entry name" value="HAD-superfamily hydrolase, subfamily IA, variant 3 containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="entry name" value="Putative phosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051806">
        <property type="entry name" value="HAD-like_SPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43481">
        <property type="entry name" value="FRUCTOSE-1-PHOSPHATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43481:SF4">
        <property type="entry name" value="GLYCEROL-1-PHOSPHATE PHOSPHOHYDROLASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG12630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="218" mass="23771" checksum="8A3CD6C7344D0C90" modified="2016-09-07" version="1">MDGTIIDSTEAVVKNWQAIGKEIGVDPEVILATSHGRRSIDVLKIYEPKLANWEYIGEKEGQIPIEFGADAVEIPGSRTFLEELEKQSIPWAIVTSGTRPLVTGWLKVMKLAHPKNLVTAEDVDNGKPDPACYLLGKKKLALSKEQPSIVVFEDAPAGIKSGKAAGFTVIALHTTHTLEQLKDAGADFIVQDMRSISLKSWTKATGEAQIEIVNALVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BT69</accession>
    <name>A0A177BT69_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1234334</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441566">
        <property type="protein sequence ID" value="OAF98583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018028949.1">
        <property type="nucleotide sequence ID" value="XM_018183812.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BT69"/>
    <dbReference type="GeneID" id="28767298"/>
    <dbReference type="InParanoid" id="A0A177BT69"/>
    <dbReference type="OrthoDB" id="3582307at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAF98583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="155" mass="18461" checksum="C5FE5890D845E2E8" modified="2016-09-07" version="1">MFASKGRLSTLLLRRWHRMLGLPRQSPPRWYRDRLREELYERRSATTHWGKVSETSDVLFSISRALYDGVPTRQLPALSRHIPAYMYMVAKYTLRWKFYRVAGGMCHAPCRESIREVINPDRDHKLLEVALRHDIDPVSFKLAAKRLRRFWPLLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BV38</accession>
    <name>A0A177BV38_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">1-alkyl-2-acetylglycerophosphocholine esterase</fullName>
            <ecNumber evidence="1">3.1.1.47</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CC84DRAFT_1048759</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.1.47" evidence="1"/>
    <dbReference type="EMBL" id="KV441566">
        <property type="protein sequence ID" value="OAF98591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018028957.1">
        <property type="nucleotide sequence ID" value="XM_018173443.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BV38"/>
    <dbReference type="GeneID" id="28756929"/>
    <dbReference type="InParanoid" id="A0A177BV38"/>
    <dbReference type="OrthoDB" id="2363873at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003847">
        <property type="term" value="F:1-alkyl-2-acetylglycerophosphocholine esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10272:SF14">
        <property type="entry name" value="PAF ACETYLHYDROLASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10272">
        <property type="entry name" value="PLATELET-ACTIVATING FACTOR ACETYLHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03403">
        <property type="entry name" value="PAF-AH_p_II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAF98591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="357" mass="38545" checksum="623968DAC46788B7" modified="2016-09-07" version="1" fragment="single">GPFAVLYNTFEILDGSRVDPLDPNNRTRKLMLSSFYPVESSKCEQICTAPYVSQNIAPYVDQFGASIGIPSGKLDKVALQVCCKTTGDENKNASNIPLVFLLHGFGGTRLIHSALAEELASAGFAVVTMDHTFESLAVEFPDGSVVTGLNDPSWDPTIPGRLEPLQDIRVDDVRYVLSQLKSMEVAAKVLPGALTGFNTERVAVFGHSFGGSTSIKLLMTDSRFVGALNLDGQQFGTITDMQQPAVLFGTTGVTPNPHNSTIDVTWAETLRHLKGWRAEIGLNNITHFGFTDVSYLNGTGALTLSKEVVDSLVGKLNGRRSFEIVSTYVTAFLDSVLRGGNTTLFDGTSQKFPEVVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BVA8</accession>
    <name>A0A177BVA8_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF7923 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1210740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441565">
        <property type="protein sequence ID" value="OAF98661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029027.1">
        <property type="nucleotide sequence ID" value="XM_018182312.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BVA8"/>
    <dbReference type="GeneID" id="28765798"/>
    <dbReference type="InParanoid" id="A0A177BVA8"/>
    <dbReference type="OrthoDB" id="2270193at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057683">
        <property type="entry name" value="DUF7923"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25540">
        <property type="entry name" value="DUF7923"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7923" evidence="1">
        <location>
            <begin position="2"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF25540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAF98661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="144" mass="15935" checksum="DBB5F57E7D577CD2" modified="2016-09-07" version="1">MLSDGSKGGPLAARLLREAVKEYLLRYLPDISNCRIMVQTFANLKQLSMDAAERGLLDNLSPSLGTFTSSFSSRVDCDFTVVQVKSVMQRKILNMCRIRSLESNAYLSLLAERLKECVKDPSCAQVFLAAARCTSVHGIPRGCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BW64</accession>
    <name>A0A177BW64_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Arrestin-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_429785</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Interacts with hulA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the arrestin family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441566">
        <property type="protein sequence ID" value="OAF98569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018028935.1">
        <property type="nucleotide sequence ID" value="XM_018186213.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BW64"/>
    <dbReference type="STRING" id="1460663.A0A177BW64"/>
    <dbReference type="GeneID" id="28769699"/>
    <dbReference type="InParanoid" id="A0A177BW64"/>
    <dbReference type="OrthoDB" id="3789699at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011021">
        <property type="entry name" value="Arrestin-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050357">
        <property type="entry name" value="Arrestin_domain-protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188">
        <property type="entry name" value="ARRESTIN DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188:SF17">
        <property type="entry name" value="FI21816P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00339">
        <property type="entry name" value="Arrestin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arrestin-like N-terminal" evidence="3">
        <location>
            <begin position="6"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAF98569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="390" mass="44268" checksum="7E845FB40F443BCF" modified="2016-09-07" version="1">MEQQITIELAEGGTIFNVENTINGNVVLRNAKPELIGSIRMVLSGRTKTKIVEKNNRNATYRGRHFLFIQKTVINAESTPLEPGQKYIWPFTIAFPTFLPPPDIRAASVDGSTPPTFRADDISFSVNAKCFVEYMIAAIIFKHQSRVVLHKREKVVKYVPNFPHHQELPPQMDKLWNQKFMARSLLLLPENEGRCLTRREKVKSVFQSSKLPCSAFQFNVSFPTCLLVGHKLRIFTTIAHLSEESTVIRPPQVTLATLSVVLKSRTSLQADGTFHPHNHVQQSTCWTRTWTNDGPFLESENWQQTFDATLPRTLHPTFNTYNISRSYYLKITGILKCANEKFDVKVRGGYIDLHLYPPRLPAVSSEGDGLPTYREAMAIAPPPRLDSDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BW79</accession>
    <name>A0A177BW79_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1234196</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441565">
        <property type="protein sequence ID" value="OAF98626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018028992.1">
        <property type="nucleotide sequence ID" value="XM_018183805.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BW79"/>
    <dbReference type="GeneID" id="28767291"/>
    <dbReference type="InParanoid" id="A0A177BW79"/>
    <dbReference type="OrthoDB" id="5358886at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008057383" evidence="1">
        <location>
            <begin position="22"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAF98626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="313" mass="35148" checksum="8881D3A18CFBFB74" modified="2016-09-07" version="1">MGLPLLLRVLPLIALLNGASGETTAAIGTFADVNTECKACPHSLCPNILAYEQGESANVTCWTRGTRIIDTTLWLRSTSDCYVTEYDLNDNITDYTSALPYCGPGSEDEDLTLEDATLKYKTECRICPTISCDTVAYLKEDTDVELTCWTPDGQVIIDDPYWMKTTNNCYVAQKNLYSKPDITYLDPCGPIPYLEIEKHFNENGTSDVDKRDAAPEPGTFAPSYLINVTVGENYALCRSCAQETCRVERRYVFDQEVWLQCLVDTNGTWWSETTDFCYVKNSDFWQSPEGDYYRNPLCEYFEEPGAGPGDGDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BWI3</accession>
    <name>A0A177BWI3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Dolichyl-phosphate-mannose--protein mannosyltransferase 4</fullName>
            <ecNumber evidence="4">2.4.1.109</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">CC84DRAFT_1191513</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-seryl-[protein] = 3-O-(alpha-D-mannosyl)-L-seryl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17377"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:13546"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137321"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-threonyl-[protein] = 3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53396"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:13547"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137323"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase 39 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.109" evidence="4"/>
    <dbReference type="EMBL" id="KV441563">
        <property type="protein sequence ID" value="OAF99038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029404.1">
        <property type="nucleotide sequence ID" value="XM_018181188.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BWI3"/>
    <dbReference type="FunCoup" id="A0A177BWI3">
        <property type="interactions" value="501"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177BWI3"/>
    <dbReference type="GeneID" id="28764674"/>
    <dbReference type="InParanoid" id="A0A177BWI3"/>
    <dbReference type="OrthoDB" id="292747at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004169">
        <property type="term" value="F:dolichyl-phosphate-mannose-protein mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23285">
        <property type="entry name" value="beta-trefoil_MIR_PMT4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.80.10.50:FF:000044">
        <property type="entry name" value="Dolichyl-phosphate-mannose-protein mannosyltransferase 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003342">
        <property type="entry name" value="ArnT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036300">
        <property type="entry name" value="MIR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016093">
        <property type="entry name" value="MIR_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027005">
        <property type="entry name" value="PMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032421">
        <property type="entry name" value="PMT_4TMC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013657">
        <property type="entry name" value="SCL35B1-4/HUT1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00803">
        <property type="entry name" value="nst"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050">
        <property type="entry name" value="DOLICHYL-PHOSPHATE-MANNOSE--PROTEIN MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050:SF51">
        <property type="entry name" value="PROTEIN O-MANNOSYL-TRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02815">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02366">
        <property type="entry name" value="PMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16192">
        <property type="entry name" value="PMT_4TMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08449">
        <property type="entry name" value="UAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00472">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82109">
        <property type="entry name" value="MIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50919">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="13 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 19" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="74"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="125"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="164"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="199"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="311"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="394"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="451"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="483"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="533"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="575"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="624"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="943"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="981"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1008"/>
            <end position="1030"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1063"/>
            <end position="1085"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="20">
        <location>
            <begin position="677"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="20">
        <location>
            <begin position="745"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="20">
        <location>
            <begin position="809"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="344"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="18">
        <location>
            <begin position="352"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00045085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00045102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00072057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="OAF99038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="1114" mass="125684" checksum="E4489F507BD83C10" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BWM7</accession>
    <name>A0A177BWM7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SEC14 cytosolic factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1169075</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441561">
        <property type="protein sequence ID" value="OAF99535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029901.1">
        <property type="nucleotide sequence ID" value="XM_018179569.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BWM7"/>
    <dbReference type="FunCoup" id="A0A177BWM7">
        <property type="interactions" value="452"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177BWM7"/>
    <dbReference type="GeneID" id="28763055"/>
    <dbReference type="InParanoid" id="A0A177BWM7"/>
    <dbReference type="OrthoDB" id="1434354at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051286">
        <property type="term" value="C:cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005628">
        <property type="term" value="C:prospore membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120019">
        <property type="term" value="F:phosphatidylcholine transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008526">
        <property type="term" value="F:phosphatidylinositol transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032120">
        <property type="term" value="P:ascospore-type prospore membrane formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031322">
        <property type="term" value="P:ascospore-type prospore-specific spindle pole body remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120010">
        <property type="term" value="P:intermembrane phospholipid transfer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006892">
        <property type="term" value="P:post-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.20">
        <property type="entry name" value="N-terminal domain of phosphatidylinositol transfer protein sec14p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011074">
        <property type="entry name" value="CRAL/TRIO_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051026">
        <property type="entry name" value="PI/PC_transfer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45657">
        <property type="entry name" value="CRAL-TRIO DOMAIN-CONTAINING PROTEIN YKL091C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45657:SF1">
        <property type="entry name" value="CRAL-TRIO DOMAIN-CONTAINING PROTEIN YKL091C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03765">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01100">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="2">
        <location>
            <begin position="108"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="299"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="331"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAF99535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="353" mass="39166" checksum="35D087F7972D6891" modified="2016-09-07" version="1">MAATGAKELTLDPKYDDYDYPTTAPTPQNGHPGHTTPEQDAQVHQLRAMLEQAGYTKNLDTLTLLRFLRARKFNVELSKQMFIDCEKWRASYADVGVEELVRTFDYKERPEIFKYYPQYYHKTDKDGRPVYIEQLGNVDLTAMAKITSQERMIQNLVCEYEKMADPRLPACSRKSGYLLETSCSIMDLKGVGIAKATSVYGYLQAVSAISQNYYPERLGKMYVINAPWGFSGVWSVVKRFLDPVTVNKIHILGSGYQKELLAQVPAENLPKLFGGSCDCPGGCELSDAGPWQDDQWVKPPKWAKKAEDKNVIDNTGVPAPTADAPQQPLTGAGPEGVEPAAAPAQNPNTANSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BWS5</accession>
    <name>A0A177BWS5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CC84DRAFT_1200393</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441564">
        <property type="protein sequence ID" value="OAF98769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029135.1">
        <property type="nucleotide sequence ID" value="XM_018181660.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BWS5"/>
    <dbReference type="FunCoup" id="A0A177BWS5">
        <property type="interactions" value="69"/>
    </dbReference>
    <dbReference type="GeneID" id="28765146"/>
    <dbReference type="InParanoid" id="A0A177BWS5"/>
    <dbReference type="OrthoDB" id="10021397at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF199">
        <property type="entry name" value="MFS EFFLUX TRANSPORTER INPD-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="24"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="60"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="221"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="255"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="292"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="359"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="476"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="25"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAF98769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="532" mass="57025" checksum="C41910CCA81AEAFF" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BXC5</accession>
    <name>A0A177BXC5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_351163</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441560">
        <property type="protein sequence ID" value="OAF99964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030330.1">
        <property type="nucleotide sequence ID" value="XM_018185877.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BXC5"/>
    <dbReference type="GeneID" id="28769363"/>
    <dbReference type="InParanoid" id="A0A177BXC5"/>
    <dbReference type="OrthoDB" id="2402960at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="113"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="235"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="273"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="304"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="339"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAF99964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="389" mass="41392" checksum="28B45F010C3AD63D" modified="2016-09-07" version="1">MPYDYADSSIDPFAQTAGTDDLFFDDDFTPVAEPVVEEAPAEVPPTAPVDTAVPATGMGQSQYAPRGPANGERGGRGRGRGGRGRGRGRGGDQAQEPREPKEKPAQEKEAKNGEAAAESAPAATEPPSTPAAPKEPKSVRGDRTLTGGTPRARLTEDEINAKLAAMKAKNEALATAHARSEADAANFEAREAIAAQKNAERKKQLAERQKIDRQNRQQMMGERERNRQMKLKAVGGREWDLEKEGGFEGTGDERRRGAARGAHGGVAGVTRTVGDEYIHQQEESNTSTTRGRGRGRGGRGGRGGRGDHQGTAKKLEAQPPPSASDFPELPSASTAGAAKDVEAPKKLDFPIRTKTEDADATEPERPGIKKQESFGLPSPMAGKSWADDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BXF1</accession>
    <name>A0A177BXF1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 13">D-3-phosphoglycerate dehydrogenase</fullName>
            <ecNumber evidence="4 13">1.1.1.95</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CC84DRAFT_1263736</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>(2R)-3-phosphoglycerate + NAD(+) = 3-phosphooxypyruvate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12641"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18110"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="EC" id="1.1.1.95"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 13">Amino-acid biosynthesis; L-serine biosynthesis; L-serine from 3-phospho-D-glycerate: step 1/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.95" evidence="4 13"/>
    <dbReference type="EMBL" id="KV441560">
        <property type="protein sequence ID" value="OAF99994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030360.1">
        <property type="nucleotide sequence ID" value="XM_018185255.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BXF1"/>
    <dbReference type="STRING" id="1460663.A0A177BXF1"/>
    <dbReference type="GeneID" id="28768741"/>
    <dbReference type="InParanoid" id="A0A177BXF1"/>
    <dbReference type="OrthoDB" id="16820at2759"/>
    <dbReference type="UniPathway" id="UPA00135">
        <property type="reaction ID" value="UER00196"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004617">
        <property type="term" value="F:phosphoglycerate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006564">
        <property type="term" value="P:L-serine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12173">
        <property type="entry name" value="PGDH_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000021">
        <property type="entry name" value="D-3-phosphoglycerate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.90">
        <property type="entry name" value="D-3-phosphoglycerate dehydrogenase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029009">
        <property type="entry name" value="ASB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006236">
        <property type="entry name" value="PGDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045626">
        <property type="entry name" value="PGDH_ASB_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01327">
        <property type="entry name" value="PGDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42938:SF22">
        <property type="entry name" value="D-3-PHOSPHOGLYCERATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42938">
        <property type="entry name" value="FORMATE DEHYDROGENASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19304">
        <property type="entry name" value="PGDH_inter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="ACT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143548">
        <property type="entry name" value="Serine metabolism enzymes domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00670">
        <property type="entry name" value="D_2_HYDROXYACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0007">Acetylation</keyword>
    <keyword evidence="7 13" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10 13" id="KW-0520">NAD</keyword>
    <keyword evidence="9 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 13" id="KW-0718">Serine biosynthesis</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase catalytic" evidence="15">
        <location>
            <begin position="12"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="16">
        <location>
            <begin position="113"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="D-3-phosphoglycerate dehydrogenase ASB" evidence="17">
        <location>
            <begin position="336"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="441"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="441"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="463"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU363003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF19304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="OAF99994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="598" mass="63461" checksum="3D8E02AB2B6639BE" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BY14</accession>
    <name>A0A177BY14_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1199770</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441561">
        <property type="protein sequence ID" value="OAF99578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029944.1">
        <property type="nucleotide sequence ID" value="XM_018181638.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BY14"/>
    <dbReference type="GeneID" id="28765124"/>
    <dbReference type="InParanoid" id="A0A177BY14"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAF99578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="68" mass="7213" checksum="058E6DA6DDA2A69F" modified="2016-09-07" version="1" fragment="single">LACRESLQSFNCCAASSARCRCCPATVAAAALSRHVIRSDLARISARLNVCCSLHPIAANRVREPAVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BY18</accession>
    <name>A0A177BY18_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1180852</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441560">
        <property type="protein sequence ID" value="OAG00026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030391.1">
        <property type="nucleotide sequence ID" value="XM_018180513.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BY18"/>
    <dbReference type="GeneID" id="28763999"/>
    <dbReference type="InParanoid" id="A0A177BY18"/>
    <dbReference type="OrthoDB" id="5335493at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038883">
        <property type="entry name" value="AN11006-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085:SF1">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG00026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="487" mass="55849" checksum="765429DFFFE33124" modified="2016-09-07" version="1">MARSSQSTVKHSAKRRYIFDLPAGFAVRPQSPTICRLSRPQARSHVRHGRKSKFDFFGLPAELRKLIYSYAVSSPHNPDAGRVYLIRQKQGEYRDFTGLPLVCNAMYKEYTSTLVQNTTVTVRAEDVNEYIGNFYADRDGALKHGDMQVSYIAYGRPVAWDVIDVASRFSFKLDVSQLLKLQCRLPRMRVSFLCYSQTFINKEPMYWTQMTEDFNELFSAAPIYGPTLPGAGPIPSILPGMVEYFEDKTDYELSVNACWPQPGHTSATSHHRPAVVFDIKFDASKNPDMPFSEHWRNRSELKRLADTPWNVDEMLELEEDLITPRFDIDQMWTLLHQTGLYNMGVSDWFLNFNREYFTLHPDDFCPPLISGDQPRIQDAGKVDKDEEMTEGNDVSATVYRPLPLPFVPFVDKAPGTENSFLEYQSITTLDEDHGFGRCSDTSFEELRLLTYKHQAGQSQEPLYPDRPEDEDTPSVFQELLREAGIDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BY70</accession>
    <name>A0A177BY70_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BYS1 domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1103492</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441561">
        <property type="protein sequence ID" value="OAF99641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030007.1">
        <property type="nucleotide sequence ID" value="XM_018175018.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BY70"/>
    <dbReference type="STRING" id="1460663.A0A177BY70"/>
    <dbReference type="GeneID" id="28758504"/>
    <dbReference type="InParanoid" id="A0A177BY70"/>
    <dbReference type="OrthoDB" id="3682664at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006771">
        <property type="entry name" value="CetA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36195:SF4">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G01990)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36195">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G01990)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04681">
        <property type="entry name" value="Bys1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008057481" description="BYS1 domain protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAF99641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="155" mass="16774" checksum="EFCFF9EA7B5D3180" modified="2016-09-07" version="1">MQYFTLAALTTLIASAAAVGKAVVKNNSQDTIYVWSVGAEISEKQTVEPGKSWSEKLHTDPTTGGIAIKITTKDDGIFNGAPQQIFAYNLVDDAVWYDLSTVDGNPFEGQHITVTNRRHETIDWPQGTNPGGEFSQIKAGDREKNVVFLVGAGES</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2023-06-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BYC7</accession>
    <name>A0A177BYC7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1169459</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441562">
        <property type="protein sequence ID" value="OAF99329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029695.1">
        <property type="nucleotide sequence ID" value="XM_018179664.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BYC7"/>
    <dbReference type="GeneID" id="28763150"/>
    <dbReference type="InParanoid" id="A0A177BYC7"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAF99329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="171" mass="18868" checksum="ED3DA5F87BBFB351" modified="2016-09-07" version="1">MDSLNLNGVSLHTAQPWKCLSSLHQDPQAKSQISAELATSTQSSAYHESHAKVFMKEPPKTPAVSVRANRDVTFASTSHGNETSVPRPSSYSMYIRNANAEWIHHAISRSHRDSLFVHQPRGIIPSRVSTAIASSEAGYCTDVSLSFKEAALSFRFRNADMLKTAVYVFCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BYT2</accession>
    <name>A0A177BYT2_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Eukaryotic translation initiation factor 3 subunit M</fullName>
            <shortName evidence="5">eIF3m</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_1155240</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CSN7/EIF3M family. CSN7 subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the eIF-3 subunit M family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441559">
        <property type="protein sequence ID" value="OAG00435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030800.1">
        <property type="nucleotide sequence ID" value="XM_018176923.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BYT2"/>
    <dbReference type="STRING" id="1460663.A0A177BYT2"/>
    <dbReference type="GeneID" id="28760409"/>
    <dbReference type="InParanoid" id="A0A177BYT2"/>
    <dbReference type="OrthoDB" id="10267031at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071541">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex, eIF3m"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03012">
        <property type="entry name" value="eIF3m"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045237">
        <property type="entry name" value="COPS7/eIF3m"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027528">
        <property type="entry name" value="eIF3m"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040750">
        <property type="entry name" value="eIF3m_C_helix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15350">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 7/DENDRITIC CELL PROTEIN GA17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15350:SF2">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18005">
        <property type="entry name" value="eIF3m_C_helix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="7">
        <location>
            <begin position="193"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="399"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="399"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAG00435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="439" mass="49474" checksum="E338A6B54592D3DE" modified="2016-09-07" version="1">MPGPQTTLLIEGTFEELADELAQYIDSLKKSQGDESSAIQAETVELLKENKKDEVLKKLVMGSQVLNQAPEKEFIAAYNLLIHLVRQSPNVPMFLPKICAHLSAPISSSPANGGGLALSVLSTVFNTLPSDHSELRFHVLLAILRVIRATSNFETLRPQLKQLDKWLEDWETEEADDRKLYLAVSDVAADAGEDEQAYTYLLRALRTFSADQVSSQEARDLSIRALKSALIHPSHFDFQDLTGLDSVQALRNSDPIYFQLLEIFNSELLDDFNDFKDEHDGWIDEVGLDGAALNRKMRLLTLASIAASAAQTRELPYAHIAKSLQIPSEDVEMWVIDVIRAGLVEGKLSQLKQTFLIHRSTYRVFGEKQWREVSSRLDMWRSGLEAVLQVVQQEKARFAQEKEDEQNRIEQKLAQVNRGGARGGNNNRQQKPMIDDEMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C033</accession>
    <name>A0A177C033_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1180595</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441559">
        <property type="protein sequence ID" value="OAG00601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030966.1">
        <property type="nucleotide sequence ID" value="XM_018180487.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C033"/>
    <dbReference type="GeneID" id="28763973"/>
    <dbReference type="InParanoid" id="A0A177C033"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG00601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="175" mass="19533" checksum="97D85A21ABFB07C9" modified="2016-09-07" version="1">MGAPSPVSQNQSTSPHIHEHGRTEPTVPNLDRYVLIHDCLQPAKQHQTGLFLNLASLEWLRPQPRIFHVVTSKRPSRDLGLLLRRVLRRLQDLGDGLVQASRFERRWPRGRSPSPRSTNPCSMTNRAPPLVDGTRPLQSNEITAFGVTRLAAGDAILGIEQPVKGLEGDTKKEFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C060</accession>
    <name>A0A177C060_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1179969</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441558">
        <property type="protein sequence ID" value="OAG00855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031220.1">
        <property type="nucleotide sequence ID" value="XM_018180451.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C060"/>
    <dbReference type="GeneID" id="28763937"/>
    <dbReference type="InParanoid" id="A0A177C060"/>
    <dbReference type="OrthoDB" id="10344458at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG00855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="326" mass="35751" checksum="72A62F591CCBAE33" modified="2016-09-07" version="1">MAFSVPNVVKKAPAADSKLISTKTLLERYAEYDIDAQQQQQAKGERGIVVISLDGDEPIFAPVDEYYTCDGVKNTKKVDGLARTANQYLAEQIALAGLTAEARIIEGKEVDGGESYEMEDLGIDKKAVKANAMREAASTATRQDVGFTAINHFLNPPERELPVYHAVGNFNDEEFRVAEINAGPADAERVSKSIYREPPELRGPMRRPGWKPLDDTMIRIAEVMTPTTHFARFSWSNYGIIGLILNAEASFGNTVWHTDISLELLLPASEEQRIELPHVVEVSLELLNPTTDAGGEKYSGSRKQSSRNAALELEVTAGALIGLTTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C0Q9</accession>
    <name>A0A177C0Q9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1263231</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441558">
        <property type="protein sequence ID" value="OAG01223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031588.1">
        <property type="nucleotide sequence ID" value="XM_018185219.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C0Q9"/>
    <dbReference type="STRING" id="1460663.A0A177C0Q9"/>
    <dbReference type="GeneID" id="28768705"/>
    <dbReference type="InParanoid" id="A0A177C0Q9"/>
    <dbReference type="OrthoDB" id="5571888at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF73">
        <property type="entry name" value="HET DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_8G01020)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="65"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG01223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="544" mass="61699" checksum="C60598AB016FE0C2" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C105</accession>
    <name>A0A177C105_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_1263479</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441559">
        <property type="protein sequence ID" value="OAG00522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030887.1">
        <property type="nucleotide sequence ID" value="XM_018185244.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C105"/>
    <dbReference type="STRING" id="1460663.A0A177C105"/>
    <dbReference type="GeneID" id="28768730"/>
    <dbReference type="InParanoid" id="A0A177C105"/>
    <dbReference type="OrthoDB" id="3771286at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF158">
        <property type="entry name" value="MEMBRANE PROTEIN PTH11-LIKE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="57"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="105"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="139"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="168"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="208"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="42"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="178"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAG00522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="251" mass="27765" checksum="3DA89F4DC23329A2" modified="2016-09-07" version="1">MSSFAQDQDVSPSWAKINRVRTQQEIVTSVLLVFMMTLLANRAYVKVCLVRQCHWDDGALFMAVIGTLILYSTTLWISARGNLDKGPPGENILEALEDDAFVTPAFVLLTVLPVTYGFLKATFFILYLQLFYQLRWMRISATVGLCVSVAAYTAFTVATLYLSIMRNIVVYGMVAIPISAFGLASDITILLLPIIAVANLNVARRKKFGAMLIFLSGLLACICSAVALYFRTRKGTAENVIYLLFATNIAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C117</accession>
    <name>A0A177C117_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1168596</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441559">
        <property type="protein sequence ID" value="OAG00498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030863.1">
        <property type="nucleotide sequence ID" value="XM_018179438.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C117"/>
    <dbReference type="STRING" id="1460663.A0A177C117"/>
    <dbReference type="GeneID" id="28762924"/>
    <dbReference type="InParanoid" id="A0A177C117"/>
    <dbReference type="OrthoDB" id="4160690at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008057559" evidence="2">
        <location>
            <begin position="18"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="154"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG00498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="226" mass="22870" checksum="FB620E5291F4A19F" modified="2016-09-07" version="1">MVTSCLLLAYFLALTTASFTPDAFFATLLKRQAPGSPEFACHDNCGTAITVSKASSGYCTDDVFLYDYENCLQCAGPDNVDIWKYYGGSLTTAAGKCSGLETEPRSGKQEDVGDAKHPGGSNSDGSSAISTAAPSETAEPVTVPAESTATTGDSAVSSAVSPVSETPTALPVHTVSGAPYGTSNGTSVEITPTASAPPEFSGGAETVQVRDVVALIGAVAAVGAFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C175</accession>
    <name>A0A177C175_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Linalool dehydratase/isomerase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1230080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441558">
        <property type="protein sequence ID" value="OAG01245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031610.1">
        <property type="nucleotide sequence ID" value="XM_018183687.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C175"/>
    <dbReference type="GeneID" id="28767173"/>
    <dbReference type="InParanoid" id="A0A177C175"/>
    <dbReference type="OrthoDB" id="2580323at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40616">
        <property type="entry name" value="LINALOOL DEHYDRATASE_ISOMERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40616:SF1">
        <property type="entry name" value="LINALOOL DEHYDRATASE_ISOMERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008057567" description="Linalool dehydratase/isomerase domain-containing protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG01245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="547" mass="61275" checksum="3135229DEBBD44AB" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C1G5</accession>
    <name>A0A177C1G5_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Helicase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CC84DRAFT_1167571</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441557">
        <property type="protein sequence ID" value="OAG01335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031700.1">
        <property type="nucleotide sequence ID" value="XM_018179204.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C1G5"/>
    <dbReference type="STRING" id="1460663.A0A177C1G5"/>
    <dbReference type="GeneID" id="28762690"/>
    <dbReference type="InParanoid" id="A0A177C1G5"/>
    <dbReference type="OrthoDB" id="413460at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015616">
        <property type="term" value="F:DNA translocase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.850">
        <property type="entry name" value="SWI2/SNF2 ATPases, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050496">
        <property type="entry name" value="SNF2_RAD54_helicase_repair"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45629:SF7">
        <property type="entry name" value="DNA EXCISION REPAIR PROTEIN ERCC-6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45629">
        <property type="entry name" value="SNF2/RAD54 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase C-terminal" evidence="5">
        <location>
            <begin position="192"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="383"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAG01335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="498" mass="55968" checksum="A926A5CC461537C0" modified="2016-09-07" version="1">MQAIQSLNTERRVILSGTPLQNDLGEFFTAIDFVNPGLLGQRSAFKRTFETPIVRSRQPDASESELEKGEARWKELVSLTSRFMIRRTAEVLTKYLPPKTEHIVFVRPTAAQAAAYRAILTSPIFAVALGNTDMALQLINVLKKICNSPALLKSKKDADDTPSEMLQSLLPLIPPNVLNSNASSAKLRVLDSLVHRIYTTTEEKIVIVSNYTQTLDMIERLLVSLSYTYCRLDGSTPAKNRQGLVEKFNRSSQKNHFAFLLSAKSGGVGLNLVGASRIVLFDIDWNPATDLQAMARIHRDGQKLPCKIYRFMIQGGLDEKIYQRQIMKMGLANAVVDNKASASSFSREELKDLFRLDERETCQTHDLLGCDCDCRGSLETQIEPPVKVEEEEEDSDDEPLRGFGSASQVDIDGQEERIKRRRKAKQPKLTLLMEYRHIDPKHLREEKTEEVDLVEKESTRGNSVDADAIALAVDDDVFLDMLKEKDSRVGFVLTKSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C1J6</accession>
    <name>A0A177C1J6_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">D-xylulose reductase</fullName>
            <ecNumber evidence="9">1.1.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Xylitol dehydrogenase A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CC84DRAFT_1190047</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Xylitol dehydrogenase which catalyzes the conversion of xylitol to D-xylulose. Xylose is a major component of hemicelluloses such as xylan. Most fungi utilize D-xylose via three enzymatic reactions, xylose reductase (XR), xylitol dehydrogenase (XDH), and xylulokinase, to form xylulose 5-phosphate, which enters pentose phosphate pathway.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="8">Carbohydrate degradation; L-arabinose degradation via L-arabinitol; D-xylulose 5-phosphate from L-arabinose (fungal route): step 4/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.9" evidence="9"/>
    <dbReference type="EMBL" id="KV441558">
        <property type="protein sequence ID" value="OAG00749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031114.1">
        <property type="nucleotide sequence ID" value="XM_018181095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C1J6"/>
    <dbReference type="FunCoup" id="A0A177C1J6">
        <property type="interactions" value="529"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177C1J6"/>
    <dbReference type="GeneID" id="28764581"/>
    <dbReference type="InParanoid" id="A0A177C1J6"/>
    <dbReference type="OrthoDB" id="3941538at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046526">
        <property type="term" value="F:D-xylulose reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003939">
        <property type="term" value="F:L-iditol 2-dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006062">
        <property type="term" value="P:sorbitol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05285">
        <property type="entry name" value="sorbitol_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000068">
        <property type="entry name" value="Sorbitol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045306">
        <property type="entry name" value="SDH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161">
        <property type="entry name" value="SORBITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161:SF9">
        <property type="entry name" value="SORBITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="12">
        <location>
            <begin position="16"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00026119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OAG00749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="358" mass="38927" checksum="6AE713690B260747" modified="2016-09-07" version="1">MTTQTKTQKNPSFILKAKNEIVYEDRPIPELPSPYDVIVKPKWTGICGSDVHYWVEGRIGHFIVEKPMVLGHESAGIVHSVGDKVTTLKVGDRVAMEPGVPCRRCIRCKEGKYNLCPDMQFAATPPFDGTLARYYALPEDYCYKLPESMSLEEGALIEPTAVAVHITRQAGIKPGDSVVVFGAGPVGLLCCAVAKAYGATKIVTVDINDERLQFALKFAATTSFKSARVSAEENAKNMIKECELGPGADIIIDASGAEPCIQTAIHALRMGGTYVQGGMGKPDINFPIMAMCTKELNVKGSFRYGSGDYQTAVDLVATKRISIKELITNKVKFDDAEEAFRDVKAGKGIKILIEGPEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C1Z6</accession>
    <name>A0A177C1Z6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1167682</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441557">
        <property type="protein sequence ID" value="OAG01476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031841.1">
        <property type="nucleotide sequence ID" value="XM_018179234.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C1Z6"/>
    <dbReference type="STRING" id="1460663.A0A177C1Z6"/>
    <dbReference type="GeneID" id="28762720"/>
    <dbReference type="InParanoid" id="A0A177C1Z6"/>
    <dbReference type="OrthoDB" id="4951845at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054416">
        <property type="entry name" value="GST_UstS-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22041">
        <property type="entry name" value="GST_C_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13409">
        <property type="entry name" value="GST_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="1">
        <location>
            <begin position="21"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="Glutathione S-transferase UstS-like C-terminal" evidence="2">
        <location>
            <begin position="115"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG01476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="243" mass="27165" checksum="3EA937103334DFA2" modified="2016-09-07" version="1">MAAPTPELILYDLASTQGVCFSPAVWRIRLLLNYKSIPYTTTFLEFPDIAPTLSALNIPPHDATTSKHPYTVPAIHHLPTNTFVMDSLAIAAFIEKTYPVPEVVLTSDLGAQIEEKARKVVGPAFYVSLVPREIRILSPRSQEYFRRTREAALGHPLEDLLAREDAAWEAIGDEARAAGALMRTHKESGPFVLGEKPCFTDFFIAGALQNARVVDVGVWERCMRVEGFREVYEACEEWMGKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C2V8</accession>
    <name>A0A177C2V8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative MFS multidrug transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CC84DRAFT_1128437</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV441558">
        <property type="protein sequence ID" value="OAG01087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031452.1">
        <property type="nucleotide sequence ID" value="XM_018175798.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C2V8"/>
    <dbReference type="STRING" id="1460663.A0A177C2V8"/>
    <dbReference type="GeneID" id="28759284"/>
    <dbReference type="InParanoid" id="A0A177C2V8"/>
    <dbReference type="OrthoDB" id="5296287at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF68">
        <property type="entry name" value="MULTIDRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01120)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="75"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="169"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="202"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="232"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="301"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="344"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="386"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="413"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="446"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="481"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="77"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="20"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAG01087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="513" mass="55808" checksum="CEB92E299F2F7475" modified="2016-09-07" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C358</accession>
    <name>A0A177C358_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_280148</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441558">
        <property type="protein sequence ID" value="OAG01207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031572.1">
        <property type="nucleotide sequence ID" value="XM_018185745.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C358"/>
    <dbReference type="GeneID" id="28769231"/>
    <dbReference type="InParanoid" id="A0A177C358"/>
    <dbReference type="OrthoDB" id="3928002at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38049:SF1">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38049">
        <property type="entry name" value="RICIN B LECTIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008057645" evidence="1">
        <location>
            <begin position="18"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG01207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="219" mass="24988" checksum="94F0FCB29F1A4BB0" modified="2016-09-07" version="1">MVLDLLALTAIPTAVGASEAVHQQRLLDEEAESEERQAPFYLDVYCDAASRKRDEVHDAIVVLKDGKLRLWPKDAHTQLPKDDPDSHAAPHPFTGFYLPFPAEDLPHRPMPARPVLGLLNWIFADTETRELRYGPRAEAREHVVGPWDWTEDDEQGLTLNGDECLVAVEEAEGGRGWAVYWDDDDDRLKAHGIAQKHRVLRCSLERRLVEDDRRRIDVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C3A6</accession>
    <name>A0A177C3A6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1179054</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441556">
        <property type="protein sequence ID" value="OAG02103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032468.1">
        <property type="nucleotide sequence ID" value="XM_018180382.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C3A6"/>
    <dbReference type="GeneID" id="28763868"/>
    <dbReference type="InParanoid" id="A0A177C3A6"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG02103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="175" mass="19223" checksum="9032C701075C66B4" modified="2016-09-07" version="1">MQASEPGSLDVRSSHGATRYIEYHMHYAELKHDGSFIHIVGASGVKVGVWVKAAQMVNPVHPGHAPATETLHGYSLEQQLRGGTSRSHPPLVRNRGLHHHPLRVHPPILRPLYLRIVRGADHACGSSGRMYLYPPTERKSKRGVSDGESMAYACAGLEGVAGGRDRDGEYYWVGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C3C7</accession>
    <name>A0A177C3C7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DUF1740-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CC84DRAFT_1151947</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NRDE2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441556">
        <property type="protein sequence ID" value="OAG01896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032261.1">
        <property type="nucleotide sequence ID" value="XM_018176776.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C3C7"/>
    <dbReference type="STRING" id="1460663.A0A177C3C7"/>
    <dbReference type="GeneID" id="28760262"/>
    <dbReference type="InParanoid" id="A0A177C3C7"/>
    <dbReference type="OrthoDB" id="297219at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902369">
        <property type="term" value="P:negative regulation of RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031048">
        <property type="term" value="P:regulatory ncRNA-mediated heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013633">
        <property type="entry name" value="NRDE-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13471:SF0">
        <property type="entry name" value="NUCLEAR EXOSOME REGULATOR NRDE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13471">
        <property type="entry name" value="TETRATRICOPEPTIDE-LIKE HELICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08424">
        <property type="entry name" value="NRDE-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="147"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="912"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="14"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="177"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="923"/>
            <end position="938"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAG01896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="1001" mass="114572" checksum="031E43ACD0122B82" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C3K4</accession>
    <name>A0A177C3K4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CC84DRAFT_1127175</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ORC4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441557">
        <property type="protein sequence ID" value="OAG01479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031844.1">
        <property type="nucleotide sequence ID" value="XM_018175765.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C3K4"/>
    <dbReference type="STRING" id="1460663.A0A177C3K4"/>
    <dbReference type="GeneID" id="28759251"/>
    <dbReference type="InParanoid" id="A0A177C3K4"/>
    <dbReference type="OrthoDB" id="343623at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005664">
        <property type="term" value="C:nuclear origin of replication recognition complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001597">
        <property type="entry name" value="Origin recognition complex subunit Orc4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016527">
        <property type="entry name" value="ORC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032705">
        <property type="entry name" value="ORC4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12087">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12087:SF0">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14629">
        <property type="entry name" value="ORC4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Orc1-like AAA ATPase" evidence="7">
        <location>
            <begin position="348"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="domain" description="Origin recognition complex subunit 4 C-terminal" evidence="8">
        <location>
            <begin position="550"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="76"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="117"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="181"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="267"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF14629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAG01479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="780" mass="85185" checksum="ACCED50224CB97D5" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C3T4</accession>
    <name>A0A177C3T4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Calcium channel subunit Mid1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_222559</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441557">
        <property type="protein sequence ID" value="OAG01821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032186.1">
        <property type="nucleotide sequence ID" value="XM_018185632.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C3T4"/>
    <dbReference type="FunCoup" id="A0A177C3T4">
        <property type="interactions" value="47"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177C3T4"/>
    <dbReference type="GeneID" id="28769118"/>
    <dbReference type="InParanoid" id="A0A177C3T4"/>
    <dbReference type="OrthoDB" id="5405745at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005262">
        <property type="term" value="F:calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098703">
        <property type="term" value="P:calcium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024338">
        <property type="entry name" value="MID1/Yam8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39142:SF1">
        <property type="entry name" value="AEL197CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39142">
        <property type="entry name" value="MID1P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12929">
        <property type="entry name" value="Mid1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG01821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="676" mass="73953" checksum="882BC46175126725" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C3V3</accession>
    <name>A0A177C3V3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_1153475</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441557">
        <property type="protein sequence ID" value="OAG01562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031927.1">
        <property type="nucleotide sequence ID" value="XM_018176840.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C3V3"/>
    <dbReference type="STRING" id="1460663.A0A177C3V3"/>
    <dbReference type="GeneID" id="28760326"/>
    <dbReference type="InParanoid" id="A0A177C3V3"/>
    <dbReference type="OrthoDB" id="1669814at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050664">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008">
        <property type="entry name" value="BENZIL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008:SF4">
        <property type="entry name" value="CHAIN DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G08710)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAG01562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="288" mass="30749" checksum="DE2F414D4935D7C5" modified="2016-09-07" version="1">MTQPAPIDLPTKDLFRLDGRTIVISGGLGAVGSTVGKAILESGGDVFFIDLAPEPAGALWSNIEATAFANGTKAWYHPLDVTQADAFPLVFDTIREQIRHPLRGLVACTGISGVCDAASYPIDAFRKILDVNIAGTFLTAQAVGKEIHRANVAGSFVLIASMSGWNSNKGINTAAYNASKSAVHQLGRSLAAEWGHPQNTFAYYPAGQANREVHPPIRVNTISPGHIETALTKEAQETGLVDDWAKQNMLGRISQVEEYRAAVLFLLADGSSYMTGADLRIDGGHCSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C4T7</accession>
    <name>A0A177C4T7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1021063</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441556">
        <property type="protein sequence ID" value="OAG02436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032801.1">
        <property type="nucleotide sequence ID" value="XM_018173381.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C4T7"/>
    <dbReference type="GeneID" id="28756867"/>
    <dbReference type="InParanoid" id="A0A177C4T7"/>
    <dbReference type="OrthoDB" id="10459856at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG02436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="200" mass="21774" checksum="2221786C5FDB29B4" modified="2016-09-07" version="1">MSVINETRCECCWALVECRRSGIYDWLVSQILRGARTQRLPVDTASQRSEAESLHCSIATVASVYVRWSGGGHLSASHPRTAPSRENQDSRPASSAARPKLVPQGITKTSLLVSSKLGSKQPRFSLRQTLRAVRMHCPRHHTTTFPVFGEGYRCMQKGGLVAQRLQPAAGRLAGPVWESRLCIVAADQTGGGPVAPASHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C4T8</accession>
    <name>A0A177C4T8_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">2-isopropylmalate synthase</fullName>
            <ecNumber evidence="7">2.3.3.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CC84DRAFT_1099206</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>3-methyl-2-oxobutanoate + acetyl-CoA + H2O = (2S)-2-isopropylmalate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21524"/>
            <dbReference type="ChEBI" id="CHEBI:1178"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.3.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 1/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.13" evidence="7"/>
    <dbReference type="EMBL" id="KV441556">
        <property type="protein sequence ID" value="OAG01899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032264.1">
        <property type="nucleotide sequence ID" value="XM_018174810.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C4T8"/>
    <dbReference type="FunCoup" id="A0A177C4T8">
        <property type="interactions" value="191"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177C4T8"/>
    <dbReference type="GeneID" id="28758296"/>
    <dbReference type="InParanoid" id="A0A177C4T8"/>
    <dbReference type="OrthoDB" id="418791at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003852">
        <property type="term" value="F:2-isopropylmalate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:L-leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07942">
        <property type="entry name" value="DRE_TIM_LeuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000045">
        <property type="entry name" value="2-isopropylmalate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.270:FF:000002">
        <property type="entry name" value="2-isopropylmalate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00572">
        <property type="entry name" value="LeuA_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013709">
        <property type="entry name" value="2-isopropylmalate_synth_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002034">
        <property type="entry name" value="AIPM/Hcit_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005668">
        <property type="entry name" value="IPM_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054692">
        <property type="entry name" value="LeuA-like_post-cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036230">
        <property type="entry name" value="LeuA_allosteric_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039371">
        <property type="entry name" value="LeuA_N_DRE-TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00970">
        <property type="entry name" value="leuA_yeast"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002991">
        <property type="entry name" value="PRK03739.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46911">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46911:SF1">
        <property type="entry name" value="2-ISOPROPYLMALATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22615">
        <property type="entry name" value="IPMS_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08502">
        <property type="entry name" value="LeuA_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00917">
        <property type="entry name" value="LeuA_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110921">
        <property type="entry name" value="2-isopropylmalate synthase LeuA, allosteric (dimerisation) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89000">
        <property type="entry name" value="post-HMGL domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00815">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00816">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="13" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0432">Leucine biosynthesis</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="15">
        <location>
            <begin position="33"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="579"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="596"/>
            <end position="615"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00009767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OAG01899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="637" mass="70611" checksum="6EF6FFB22B8DE2B3" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C516</accession>
    <name>A0A177C516_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1219671</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG02713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033078.1">
        <property type="nucleotide sequence ID" value="XM_018183099.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C516"/>
    <dbReference type="STRING" id="1460663.A0A177C516"/>
    <dbReference type="GeneID" id="28766585"/>
    <dbReference type="InParanoid" id="A0A177C516"/>
    <dbReference type="OrthoDB" id="3919855at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG02713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="170" mass="19247" checksum="2BFE0FAD5383F6D1" modified="2016-09-07" version="1">MSIDMDVELMFDELDYVFAPYLRYVPLPARNDMKTNKSMRQGFSNLFQRFDMVTRTEGAAGLPTEANIRLHIQIESEWPPHCKNYLARGGPIYAIGSWLFEAAMNEDEIAGAGDLMLPDEDCKEEMRNSRLGIEQASLPVCRNDLEYVRGSAVSTTTWIKLHSGATFSVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C548</accession>
    <name>A0A177C548_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1250850</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG02874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033239.1">
        <property type="nucleotide sequence ID" value="XM_018184313.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C548"/>
    <dbReference type="GeneID" id="28767799"/>
    <dbReference type="InParanoid" id="A0A177C548"/>
    <dbReference type="OrthoDB" id="190201at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="134"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG02874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="406" mass="42825" checksum="EA90813A69E5FF12" modified="2016-09-07" version="1">MRASTALAFAAGVSAQYSEWLLPANPGGAVPAGVKTPSTSGFDNPTIQPARGGLAVCVSGTVSVEASTSRNLKFTFELPQNQSQVTNTFLKLLSNPSPFAQELVGGTQSVSGTYEIGVTLCTPANNTTPDQVQLLTHGIGFDRYYWDFAPGYSYVDVAAQYGHATLLYDRLGVGKSTKADPLNVVQAALEVEIANILAQKLRAGAFSSHAFSTVIGTGHSFGSIITQAVTSQYPQAIDAAILTGFSANSTGVAPFTLALNLAIASQNQPYRFGALNNGYLVDGSATASEICFFHAPGFDPEILSLAEATKGTATFGEFFSISAVTRPAANWTKPVAVINGDEDLAFCFGNCSAPVNKAEAVFPLLYPRAKTTGAYLARNTGHGLNLHYSAMEAYHYIQEFIGKNVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C5M0</accession>
    <name>A0A177C5M0_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1220430</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441556">
        <property type="protein sequence ID" value="OAG02068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032433.1">
        <property type="nucleotide sequence ID" value="XM_018183166.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C5M0"/>
    <dbReference type="GeneID" id="28766652"/>
    <dbReference type="InParanoid" id="A0A177C5M0"/>
    <dbReference type="OrthoDB" id="330671at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009218">
        <property type="entry name" value="HD_phosphohydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21174">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21174:SF0">
        <property type="entry name" value="HD PHOSPHOHYDROLASE FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF035170">
        <property type="entry name" value="HD_phosphohydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG02068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="192" mass="22253" checksum="7EDF9175E470A883" modified="2016-09-07" version="1">MDARTIHIPDHIKQCYQQPNRHYHNLGHVAHMLRLVPDDHPHMLELVYATWLHDCVYDPKAAHSKNEGESIRTWRSHVEENEGLSKIKDIVSLMIECTMTHKPPYEPPADEAQIELINRFLDMDMDILAFSREGYLGYAKKVRREYAHLTDEQFRKGRAAFLRSAIDKGNVFPLDENPGKNEIALGNMKAEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C6Q1</accession>
    <name>A0A177C6Q1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ARM repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_1188142</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VAC14 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG03434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033799.1">
        <property type="nucleotide sequence ID" value="XM_018180974.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C6Q1"/>
    <dbReference type="FunCoup" id="A0A177C6Q1">
        <property type="interactions" value="882"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177C6Q1"/>
    <dbReference type="GeneID" id="28764460"/>
    <dbReference type="InParanoid" id="A0A177C6Q1"/>
    <dbReference type="OrthoDB" id="5574975at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070772">
        <property type="term" value="C:PAS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006661">
        <property type="term" value="P:phosphatidylinositol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026825">
        <property type="entry name" value="Vac14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021841">
        <property type="entry name" value="VAC14_Fig4p-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16023:SF0">
        <property type="entry name" value="PROTEIN VAC14 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16023">
        <property type="entry name" value="TAX1 BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12755">
        <property type="entry name" value="Vac14_Fab1_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11916">
        <property type="entry name" value="Vac14_Fig4_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="HEAT" evidence="5">
        <location>
            <begin position="86"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="Vacuolar protein 14 C-terminal Fig4-binding" evidence="7">
        <location>
            <begin position="617"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="292"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="493"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="811"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="885"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="299"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="313"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="811"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="931"/>
            <end position="943"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF11916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAG03434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="949" mass="104854" checksum="5F713C9849F3DEF6" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C745</accession>
    <name>A0A177C745_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CC84DRAFT_1165695</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG03463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033828.1">
        <property type="nucleotide sequence ID" value="XM_018178777.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C745"/>
    <dbReference type="GeneID" id="28762263"/>
    <dbReference type="InParanoid" id="A0A177C745"/>
    <dbReference type="OrthoDB" id="2130629at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718:SF27">
        <property type="entry name" value="TRANSPORTER, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="61"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="154"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="187"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="216"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="258"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="289"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="329"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="393"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="420"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="505"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="63"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAG03463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="536" mass="56881" checksum="D0A1076350A6F011" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2023-06-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C783</accession>
    <name>A0A177C783_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_899940</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG02607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032972.1">
        <property type="nucleotide sequence ID" value="XM_018187842.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C783"/>
    <dbReference type="GeneID" id="28771328"/>
    <dbReference type="InParanoid" id="A0A177C783"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG02607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="103" mass="11768" checksum="CAF6BE7A4C563E0E" modified="2016-09-07" version="1">MIGCNVATSRPSQQTHRPDILDDSIAQCTIKQKVPNARAHSYDINSRVLQNRNTYNSHGGKGLFVWKEFSAVYISGVDFYTFSLVHVIEGLWFSFSVFNNYFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C7J2</accession>
    <name>A0A177C7J2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1220240</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG03376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033741.1">
        <property type="nucleotide sequence ID" value="XM_018183150.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C7J2"/>
    <dbReference type="GeneID" id="28766636"/>
    <dbReference type="InParanoid" id="A0A177C7J2"/>
    <dbReference type="OrthoDB" id="73875at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG03376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="149" mass="16636" checksum="C10154DF53FDB3D2" modified="2016-09-07" version="1">MFHAQESRMTRSQGWRADGYDMGGANARGAGSHCDEPTPINRNNLWYVGAAQGSMPMGFYTRFQVWAWTLFNTGYMSTPGISPILSGATFRRNGDIDLTNQPAFLQWGDESSEFSGANPYSISFRIRRDTNDRNGYAYEFGIPDPGNPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C7W3</accession>
    <name>A0A177C7W3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">PTR2-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CC84DRAFT_1165853</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG03645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034010.1">
        <property type="nucleotide sequence ID" value="XM_018178811.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C7W3"/>
    <dbReference type="GeneID" id="28762297"/>
    <dbReference type="InParanoid" id="A0A177C7W3"/>
    <dbReference type="OrthoDB" id="8904098at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071916">
        <property type="term" value="F:dipeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000085">
        <property type="entry name" value="MFS peptide transporter Ptr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000109">
        <property type="entry name" value="POT_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018456">
        <property type="entry name" value="PTR2_symporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11654">
        <property type="entry name" value="OLIGOPEPTIDE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00854">
        <property type="entry name" value="PTR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01022">
        <property type="entry name" value="PTR2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01023">
        <property type="entry name" value="PTR2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="161"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="186"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="244"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="271"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="353"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="433"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="518"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="547"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="42"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAG03645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="609" mass="66632" checksum="34C5E8C3CFFAF26E" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C806</accession>
    <name>A0A177C806_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NADH-ubiquinone oxidoreductase 14 kDa subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1151214</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG02982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033347.1">
        <property type="nucleotide sequence ID" value="XM_018176733.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C806"/>
    <dbReference type="STRING" id="1460663.A0A177C806"/>
    <dbReference type="GeneID" id="28760219"/>
    <dbReference type="InParanoid" id="A0A177C806"/>
    <dbReference type="OrthoDB" id="2141050at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39218">
        <property type="entry name" value="OXIDOREDUCTASE 14 KDA SUBUNIT, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12110)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39218:SF1">
        <property type="entry name" value="OXIDOREDUCTASE 14 KDA SUBUNIT, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12110)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG02982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="86" mass="10080" checksum="8EB6896AC2032A24" modified="2016-09-07" version="1">MVHKVLFWGGFGVGVRLWQLGIEMRPLFNRESLWVYPVFAGIGGSFGYWLMGVEQRQWRVLADRRDALLEKRARRKEREEAAAQEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C867</accession>
    <name>A0A177C867_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">3-oxoacyl-[acyl-carrier-protein] reductase</fullName>
            <ecNumber evidence="2">1.1.1.100</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CC84DRAFT_1151148</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a (3R)-hydroxyacyl-[ACP] + NADP(+) = a 3-oxoacyl-[ACP] + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17397"/>
            <dbReference type="Rhea" id="RHEA-COMP:9916"/>
            <dbReference type="Rhea" id="RHEA-COMP:9945"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78776"/>
            <dbReference type="ChEBI" id="CHEBI:78827"/>
            <dbReference type="EC" id="1.1.1.100"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.100" evidence="2"/>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG02947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033312.1">
        <property type="nucleotide sequence ID" value="XM_018176731.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C867"/>
    <dbReference type="STRING" id="1460663.A0A177C867"/>
    <dbReference type="GeneID" id="28760217"/>
    <dbReference type="InParanoid" id="A0A177C867"/>
    <dbReference type="OrthoDB" id="417891at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004316">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032787">
        <property type="term" value="P:monocarboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000173">
        <property type="entry name" value="3-oxoacyl-[acyl-carrier protein] reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050259">
        <property type="entry name" value="SDR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42879">
        <property type="entry name" value="3-OXOACYL-(ACYL-CARRIER-PROTEIN) REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42879:SF2">
        <property type="entry name" value="3-OXOACYL-[ACYL-CARRIER-PROTEIN] REDUCTASE FABG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAG02947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="266" mass="28139" checksum="3CAC04EF70E130CE" modified="2016-09-07" version="1">MSTGHLKAPLQGKIALVTGATGGIGTAVCRRLAALGCSIGIHYNTDQDAALALLEEFKEDYMHAFGSKFVCYGADLGNYEEVRELHEHIVALLGPPNILINNHGATVQTGTKSIDEVSISAFEDAWRINCGSSYLLTQLCMPALEGEGWGRVIFVSSVAGITGGIIGPHYASAKSALHGLIHWLANTYAKKGITVNGVAPALIEQTKMLPGSNEELSKSGANDIVVVPVGRLGMPDEVAETVLWMINTSYVTNKVIAVDGGMVPQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C880</accession>
    <name>A0A177C880_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1261699</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG03062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033427.1">
        <property type="nucleotide sequence ID" value="XM_018185087.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C880"/>
    <dbReference type="GeneID" id="28768573"/>
    <dbReference type="InParanoid" id="A0A177C880"/>
    <dbReference type="OrthoDB" id="3779139at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG03062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="345" mass="39112" checksum="320DF361C6D5DBF5" modified="2016-09-07" version="1">MCFFPQVTHACGHTTLVTHPKAIRLCPYALRFCTQDLDRAPPCCTPLGPHGRDDLYNKDIIFAIIEDSSQCAGCHATESTPARAVRVAQSNQSWETEELQGLKLSLNKEIENVEKGCQVVEFDQKIRAIVKTIIHPWLRGMLEVNGDGYSSLGEVVLHRVRNVQRLVDNVLAMCNTGVPLNSLRIDFHAAVDQYEKAFNLMDHFQQIVRLLHDLENRGSYQNELCKQAEMCQLLLQGPQVAPHDLAYLQSGFKTPNAFQPKRDSGVVPGTYLSSHHALSKNWYASALVNLLKQKDVLPFRREFYHGPSRNTNKRRRTPPAIQIIVSDEERAKFPKPDMKYWSHAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C8S2</accession>
    <name>A0A177C8S2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MYND-type zinc finger protein MUB1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1096941</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG03110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033475.1">
        <property type="nucleotide sequence ID" value="XM_018174690.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C8S2"/>
    <dbReference type="FunCoup" id="A0A177C8S2">
        <property type="interactions" value="69"/>
    </dbReference>
    <dbReference type="GeneID" id="28758176"/>
    <dbReference type="InParanoid" id="A0A177C8S2"/>
    <dbReference type="OrthoDB" id="5594178at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990304">
        <property type="term" value="C:MUB1-RAD6-UBR2 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007163">
        <property type="term" value="P:establishment or maintenance of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051664">
        <property type="entry name" value="MYND-type_zinc_finger"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47442">
        <property type="entry name" value="MYND-TYPE ZINC FINGER PROTEIN MUB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47442:SF1">
        <property type="entry name" value="MYND-TYPE ZINC FINGER PROTEIN MUB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="281"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="281"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG03110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="597" mass="66210" checksum="0D477E389A2E1336" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C8S9</accession>
    <name>A0A177C8S9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_961878</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG03178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033543.1">
        <property type="nucleotide sequence ID" value="XM_018187970.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C8S9"/>
    <dbReference type="GeneID" id="28771456"/>
    <dbReference type="InParanoid" id="A0A177C8S9"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="160"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG03178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="227" mass="23859" checksum="4D019AB089164357" modified="2016-09-07" version="1">MHQTRRGTLVSRSDRPGMEGRPGKPRVDGGRVRFAGIASAAVTPRQGAEGGVGSDGRACSPEPCWCSFGGLWACARCGGRSALLAREAVRSCCPISRRPAAPAAGCMRPPQPLGPLRRRTSVCICIPSNASQSPHLAHSVPRPRTNSASLQAAKHLLPLTASPASSPTNTSPPWCPGPSPSPPATSRTFSTADPQSHHPACLSAMWRFLAHARMPSLQRAPCWPTAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CAA4</accession>
    <name>A0A177CAA4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HET-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1053817</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG03759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034124.1">
        <property type="nucleotide sequence ID" value="XM_018173512.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CAA4"/>
    <dbReference type="STRING" id="1460663.A0A177CAA4"/>
    <dbReference type="GeneID" id="28756998"/>
    <dbReference type="InParanoid" id="A0A177CAA4"/>
    <dbReference type="OrthoDB" id="5135333at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF12">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="40"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG03759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="359" mass="40564" checksum="70072C4EB7ADAD44" modified="2016-09-07" version="1" fragment="single">CLNNHGHLCSTHNIVTPKPRIRLIDVDKRCIVNGSGTENWVALSYVWGGANTVLMTTENINQHETQGSLEGILPLTIEDALRVTQALGERYLWVDCLCILQDCEEDKSIHLPRMGDIYRHAVVTIVAASGSNAAAGLPWIRNSITRSEQLFIQVRPSFRLGDYGVATMMDPPESPDCDYATGSPWSMRAWTFQERLLSRRVLIFTKDLIYWECEQSIWREDCFGELPAEFPQIFTSGFGSGTFWSHLDLSRLWRSHPFDIVNTYRQVVSHYTGLQLTYQEDGLHAISGVLAALEMRSGSKFLWGLPTAMLSAALIWESHSDDDATLSSRNQRRTAKHMLGPTQNSTSHCPFPSWSWVGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CAP4</accession>
    <name>A0A177CAP4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Inosine monophosphate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_801153</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG04733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035098.1">
        <property type="nucleotide sequence ID" value="XM_018187472.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CAP4"/>
    <dbReference type="FunCoup" id="A0A177CAP4">
        <property type="interactions" value="21"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CAP4"/>
    <dbReference type="GeneID" id="28770958"/>
    <dbReference type="InParanoid" id="A0A177CAP4"/>
    <dbReference type="OrthoDB" id="412383at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018580">
        <property type="term" value="F:nitronate monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04730">
        <property type="entry name" value="NPD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004136">
        <property type="entry name" value="NMO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32332">
        <property type="entry name" value="2-NITROPROPANE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32332:SF28">
        <property type="entry name" value="DIOXYGENASE FAMILY OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G09600)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03060">
        <property type="entry name" value="NMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51412">
        <property type="entry name" value="Inosine monophosphate dehydrogenase (IMPDH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0288">FMN</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAG04733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="358" mass="38272" checksum="6167E51F3839AC52" modified="2016-09-07" version="1">MPFNTELTRALGIKVPVVQGGMQWVGYAELASAVSNAGGLGILTALTQPTPEDLRKEIRRCRTMTKNPFGVNLTLLPALVPPDYAAYAQVIIDEGIKIVETAGNSPGPVIKQLKAANCIILHKCTTIRHAQSAVKMGVDFLSIDGFECAGHVGETDITNFILLSRARQSLGGVPFIASGGFADGQGLAAALALGACGINMGTRFMCTVEAPIHQKIKQAIVDAQETDTELVLRRWRNTTRLFGNNVAKQAVKVEKESTTGKFEEVAEYVSGKRGRQVFLNGDKDFGVWTAGQVIGLIHDVPTCDALLKRIEREAVETLASKQDLFVQDGDQSVGPSATVGKNTNNPGAEVWGVGKSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CB34</accession>
    <name>A0A177CB34_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CC84DRAFT_1219161</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG03910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034275.1">
        <property type="nucleotide sequence ID" value="XM_018183059.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CB34"/>
    <dbReference type="GeneID" id="28766545"/>
    <dbReference type="InParanoid" id="A0A177CB34"/>
    <dbReference type="OrthoDB" id="5329176at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF47">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="37"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="85"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="119"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="171"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="200"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="234"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="25"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="277"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="359"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="361"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAG03910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="383" mass="42158" checksum="A1C78BD2153C5DCF" modified="2016-09-07" version="1">MANLHPLAGGLHILLFILGILSLLLRFYSRAFVIRRWGLDDTLAVATLFLYVALQAVHQLMLNAGCGLDGPNECSPTINSSIPKILLATQVLYALTHFTIKSTFLAFYVHLSPARTFRILVYVGAALNASVFITNELLIVLRCQPPKEVFSPGSTPDAKCMSQAVTFWSPVVLNLSVDVYILTLPIPVIWGLRMPAKRRLAVLAIFSSGFSAILTSAFWVFAWGKMRDHQTSPALAINTIISSVELFFAVMAVNMPAFKPLWTRMVGDVTTPPAASYKMDGWSREKSTPRSRPAPVESSIISSMGKSSRDSRGVLGSESEEDLVEAQTPLHSDGASAAEAGRRRVWMDEDGIEFVIAVPSRSDKYSSSSERRRDPRDEICFDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CBC4</accession>
    <name>A0A177CBC4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Amino acid transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CC84DRAFT_886762</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG04078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034443.1">
        <property type="nucleotide sequence ID" value="XM_018187794.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CBC4"/>
    <dbReference type="FunCoup" id="A0A177CBC4">
        <property type="interactions" value="185"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CBC4"/>
    <dbReference type="GeneID" id="28771280"/>
    <dbReference type="InParanoid" id="A0A177CBC4"/>
    <dbReference type="OrthoDB" id="4476201at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015495">
        <property type="term" value="F:gamma-aminobutyric acid:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015489">
        <property type="term" value="F:putrescine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF6">
        <property type="entry name" value="GABA-SPECIFIC PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="47"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="136"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="171"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="197"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="276"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="332"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="380"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="411"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="453"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="484"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAG04078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="559" mass="60235" checksum="B0302D01411861E0" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CBS6</accession>
    <name>A0A177CBS6_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Fibroin-3 related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1218492</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG05114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035479.1">
        <property type="nucleotide sequence ID" value="XM_018183007.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CBS6"/>
    <dbReference type="STRING" id="1460663.A0A177CBS6"/>
    <dbReference type="GeneID" id="28766493"/>
    <dbReference type="InParanoid" id="A0A177CBS6"/>
    <dbReference type="OrthoDB" id="5401332at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005935">
        <property type="term" value="C:cellular bud neck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037504">
        <property type="entry name" value="PSI_induc_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40018">
        <property type="entry name" value="[PSI+] INDUCTION PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40018:SF1">
        <property type="entry name" value="[PSI+] INDUCTION PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="38"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="222"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="222"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="269"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="334"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="375"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="431"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="480"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG05114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="489" mass="52115" checksum="A16259FE06DD63FB" modified="2016-09-07" version="1">MATTLVMRSLLAARNPLDDAKDTLSSWDKCMAKNYCKWPVIVAIIVGGIIVLSVVLCIARCVCCGAELACCCFKCCTCCCPSGGRSGHKRVKTPPPRPYDASAYSGGLPPAPVPVPMDTRPPQQQYRSHAAPTFSPAPAPTFNPAPAPSVSSYNTAPKAEAPQFARFDAHAPPANEDALPAMPSWRDARTTHVEEEYIPEKRDDVEMDRLDQNGSVAGTSMAAVAAGGAARRSPGPARSPVQRLQAEEGYGDPQGYQDGSYANNAPRRSPSNAPSGYSSAYSQQADGYRGASPVDQSLSPAPLYGAGAGYAQNNQQHDRRSPGPGYNGSSRRSPGPGYDQYGQYGQQQQQQPQQYGQQPQQYGQQNTRQSPFPLNTNNYGYTTNNPQYSPRDVSPVTPSNDMYNTGVPAALAPGRDPSPVYAPSGSTRFEPPAPSGSPAPAYPGQQTYGATEAAQPAQTPYRAYTPAQTQDPYAGGVPRRPVDGSWKEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CBZ1</accession>
    <name>A0A177CBZ1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">EthD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_787471</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG04329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034694.1">
        <property type="nucleotide sequence ID" value="XM_018187388.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CBZ1"/>
    <dbReference type="STRING" id="1460663.A0A177CBZ1"/>
    <dbReference type="GeneID" id="28770874"/>
    <dbReference type="InParanoid" id="A0A177CBZ1"/>
    <dbReference type="OrthoDB" id="2519291at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG04329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="124" mass="13850" checksum="CF35A0167115332B" modified="2016-09-07" version="1">MTFSQLPSLHHTKVHPFASRVQNPRDTKYVELLKEIAVDHLPLTHPLLHRSHERVGAQKNFTYDAIAELVLPDEASFQTFFGIISEPDAATRIAAREEACIVRGKVRAVVLCETTSTTLENGDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CC21</accession>
    <name>A0A177CC21_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Cysteine synthase 1</fullName>
            <ecNumber evidence="5">2.5.1.47</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">O-acetylserine (thiol)-lyase 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">O-acetylserine sulfhydrylase 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">O-succinylserine sulfhydrylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">CC84DRAFT_1176641</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the conversion of O-succinyl-L-serine into cysteine, the last step in the cysteine biosynthesis pathway. Can also use O-acetyl-L-serine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>O-acetyl-L-serine + hydrogen sulfide = L-cysteine + acetate</text>
            <dbReference type="Rhea" id="RHEA:14829"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:58340"/>
            <dbReference type="EC" id="2.5.1.47"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>O-succinyl-L-serine + hydrogen sulfide = L-cysteine + succinate</text>
            <dbReference type="Rhea" id="RHEA:53816"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:136856"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-cysteine biosynthesis; L-cysteine from L-serine: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cysteine synthase/cystathionine beta-synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.47" evidence="5"/>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG04422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034787.1">
        <property type="nucleotide sequence ID" value="XM_018180234.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CC21"/>
    <dbReference type="STRING" id="1460663.A0A177CC21"/>
    <dbReference type="GeneID" id="28763720"/>
    <dbReference type="InParanoid" id="A0A177CC21"/>
    <dbReference type="OrthoDB" id="10259545at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004124">
        <property type="term" value="F:cysteine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006535">
        <property type="term" value="P:cysteine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01561">
        <property type="entry name" value="CBS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000011">
        <property type="entry name" value="Cysteine synthase (o-acetylserine)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050214">
        <property type="entry name" value="Cys_Synth/Cystath_Beta-Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001216">
        <property type="entry name" value="P-phosphate_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007989">
        <property type="entry name" value="PRK10717.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10314">
        <property type="entry name" value="CYSTATHIONINE BETA-SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00901">
        <property type="entry name" value="CYS_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0198">Cysteine biosynthesis</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="19">
        <location>
            <begin position="45"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00050981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00058228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00072087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00078262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00079147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00081847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="OAG04422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="377" mass="40825" checksum="121019ED58A7B0DD" modified="2016-09-07" version="1">MLRTAPRRFAASLWRGAESIQSEAGYQKAINISKAQGIGQRGFLDAIGKTPLIRLKRLSEETGCNVLGKAEFQNPGGSVKDRAALYVVENAEKLGLLKPGGTVIEGTAGNTGIGLAHVCRSKGYKLVIYMPNTQSQGKIDLLRLLGAEVYPVPAVAFDNPQNYNHQAKRHAESLDNAVWTNQFDNVANRQAHIETTGPEIWYQTDGKIDAFTCATGTGGSLAGVTRYLKEKSDGRVKCFLADPPGSVLHSYIQSGGKLAERQGGSITEGIGQGRVTDNLKPDIDLLDGSVHISDEKTIEMVYRCLDEEGLYLGASSCLNVVAAKEVAEKLGKGSTVVTLLCDGAYRYADRLFSKKWLEEKKLLGAIPQHLTKYIVLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CC24</accession>
    <name>A0A177CC24_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Mitochondrial carrier</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CC84DRAFT_1165518</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG05205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035570.1">
        <property type="nucleotide sequence ID" value="XM_018178732.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CC24"/>
    <dbReference type="FunCoup" id="A0A177CC24">
        <property type="interactions" value="921"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CC24"/>
    <dbReference type="GeneID" id="28762218"/>
    <dbReference type="InParanoid" id="A0A177CC24"/>
    <dbReference type="OrthoDB" id="448427at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000107">
        <property type="entry name" value="Mitochondrial dicarboxylate carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050391">
        <property type="entry name" value="Mito_Metabolite_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45618">
        <property type="entry name" value="MITOCHONDRIAL DICARBOXYLATE CARRIER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00784">
        <property type="entry name" value="MTUNCOUPLING"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="22"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="120"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="220"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OAG05205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="311" mass="34752" checksum="ADBA0400B53BB528" modified="2016-09-07" version="1">MPALEKQVSAAELRKSQDVKKKPIHYPFWFGGSASCFAACFTHPLDLGAHGFQVRLQMQSAQGPRLNMIQMFGHVAKTDGIMGLYRGLSASQLRQLTYSMTRFGVYEALKDRVTTADTKPSFLTLVAMASVSGFLGGVAGNPGDILNVRMQHDAALPPEQRRKYKHVFDGLIRTAREEGVGRLWRGVWPNSSRAVLMTVGQLASYDGFKRVLLEKTPLQDNLTTHFTASFLAGFVATTICSPVDVIKTKVMGSTESKSIMKIVTETTRAEGLRWMFKGWVPSFIRMGPHTILTFVFLEQHKKMYRKLKDLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CC28</accession>
    <name>A0A177CC28_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NAP family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_1121412</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the nucleosome assembly protein (NAP) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG04751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035116.1">
        <property type="nucleotide sequence ID" value="XM_018175608.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CC28"/>
    <dbReference type="FunCoup" id="A0A177CC28">
        <property type="interactions" value="565"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CC28"/>
    <dbReference type="GeneID" id="28759094"/>
    <dbReference type="InParanoid" id="A0A177CC28"/>
    <dbReference type="OrthoDB" id="19419at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.90">
        <property type="entry name" value="Nucleosome assembly protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037231">
        <property type="entry name" value="NAP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002164">
        <property type="entry name" value="NAP_family"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11875">
        <property type="entry name" value="TESTIS-SPECIFIC Y-ENCODED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00956">
        <property type="entry name" value="NAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143113">
        <property type="entry name" value="NAP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="215"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="280"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="218"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="237"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="284"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAG04751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="331" mass="38082" checksum="8504083DB34AC2B0" modified="2016-09-07" version="1">MAENVNEEEVQARFEELSVLEAEFEDVELELIRKSNALNAPLWKKRAEVIAKIPHFWTLVFEQAPPELDSFILPSDAQIFAECFESLEVTRFEIDDPKGSPRSISIKFGFGDNEYFEDKVLEKKFWFRKSRDWEGLVSEPVKINWKKEQDTTFGLTDAAIELAEARKKADSKAKETELPEYKKLASLIEESTEASPSFFAWFAFVSDYRWVSAEESEQAEKEDAERLEKLKRGEKVEEPEDDDDDTIDYQETEVFPQGGEIATLIAEDLWPSAIKYYKQSHEQDGEDFSDIDVEDMDEDEDEDESGDEIDIRGLVGKGRAGSPPTKKQRKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CC42</accession>
    <name>A0A177CC42_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_1164913</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. AB hydrolase 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG04442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034807.1">
        <property type="nucleotide sequence ID" value="XM_018178595.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CC42"/>
    <dbReference type="STRING" id="1460663.A0A177CC42"/>
    <dbReference type="GeneID" id="28762081"/>
    <dbReference type="InParanoid" id="A0A177CC42"/>
    <dbReference type="OrthoDB" id="437457at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008474">
        <property type="term" value="F:palmitoyl-(protein) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050565">
        <property type="entry name" value="LYPA1-2/EST-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003140">
        <property type="entry name" value="PLipase/COase/thioEstase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10655">
        <property type="entry name" value="LYSOPHOSPHOLIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10655:SF67">
        <property type="entry name" value="PHOSPHOLIPASE_CARBOXYLESTERASE SUPERFAMILY (AFU_ORTHOLOGUE AFUA_5G09340)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02230">
        <property type="entry name" value="Abhydrolase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phospholipase/carboxylesterase/thioesterase" evidence="3">
        <location>
            <begin position="24"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="10"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAG04442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="243" mass="25998" checksum="732CDE13C423F5B5" modified="2016-09-07" version="1">MPGRLPTQADFPSSVTLSITPPPPSHPATNILILLHGLGDTHSAFTKLGTQLNLPETACISLRAPAPLPFDLPGFHWGDDMVFDQHSGEMDVDTGFAASTKVVLDTVIKEGLIAKCGYAAREIVLFGFAQGGMLALQVASSCGEELGGVVSVGGAPSLSAPLPTVGKKNRTPVLVCKASRGSSVTDSAEKRLKDIFEFTEVKEWKRVGDGMMRNREEMLPIMQFLARRLRSRRGVPEGSVELS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CCQ4</accession>
    <name>A0A177CCQ4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HCP-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1259923</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG04558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034923.1">
        <property type="nucleotide sequence ID" value="XM_018184949.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CCQ4"/>
    <dbReference type="STRING" id="1460663.A0A177CCQ4"/>
    <dbReference type="GeneID" id="28768435"/>
    <dbReference type="InParanoid" id="A0A177CCQ4"/>
    <dbReference type="OrthoDB" id="5379420at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG04558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="443" mass="49401" checksum="63D5D4FD04E63A9C" modified="2016-09-07" version="1">MSIRPSVIRGARRIINKEPCIFCLHRSPLGARTFTIKQRIDPRKGTPGEVRADIDQRNRRLYFRMLEADKLIPCKLEDANKIINHFVSNRASMNPATNARTLAQQFKLKVVHLPMLAIPMFRIPDVNDTTRQLPPSSNAPLAASLLVACSAAGDLQATLQILNAVYYSAKVHNMPKAAEMARLYTPKQISDARRMLEQLAEGKQGNSGATGDANAMTLHGKFLELAGDTAQARFFYEKALERYDTKIWRGYPHPMALPWLTPWTELVKLEEASPAPSVERITKAIKFGALKADDPMAYYKLATLQASKNPDWLNYMSKAAASGHPEAMYELGLFYHEVQAQPSTFLGNTGFRKALNFITSWKRNGAADFGMEWLNAAATGGHKPAVMEMARMYERNGQEDQVQNCLEVVAADPPNGVPEEWPDLAAQARHRLAALKSVKRAMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CDQ1</accession>
    <name>A0A177CDQ1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">LuxS/MPP-like metallohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CC84DRAFT_1094163</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M16 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG04830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035195.1">
        <property type="nucleotide sequence ID" value="XM_018174550.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CDQ1"/>
    <dbReference type="FunCoup" id="A0A177CDQ1">
        <property type="interactions" value="1002"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CDQ1"/>
    <dbReference type="GeneID" id="28758036"/>
    <dbReference type="InParanoid" id="A0A177CDQ1"/>
    <dbReference type="OrthoDB" id="952271at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043171">
        <property type="term" value="P:peptide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000003">
        <property type="entry name" value="Insulin-degrading enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000005">
        <property type="entry name" value="nardilysin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000004">
        <property type="entry name" value="Putative insulin-degrading enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050626">
        <property type="entry name" value="Peptidase_M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032632">
        <property type="entry name" value="Peptidase_M16_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054734">
        <property type="entry name" value="PqqF-like_C_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43690:SF18">
        <property type="entry name" value="INSULIN-DEGRADING ENZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43690">
        <property type="entry name" value="NARDILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16187">
        <property type="entry name" value="Peptidase_M16_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22456">
        <property type="entry name" value="PqqF-like_C_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M16 N-terminal" evidence="8">
        <location>
            <begin position="38"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 C-terminal" evidence="9">
        <location>
            <begin position="227"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 middle/third" evidence="10">
        <location>
            <begin position="412"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="domain" description="Coenzyme PQQ synthesis protein F-like C-terminal lobe" evidence="11">
        <location>
            <begin position="805"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="123"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF16187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF22456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OAG04830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="1095" mass="124837" checksum="137F1FCC8BBA49B2" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CFH6</accession>
    <name>A0A177CFH6_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Vacuolar import and degradation protein-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_1092665</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GID4/VID24 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG06364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036729.1">
        <property type="nucleotide sequence ID" value="XM_018174475.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CFH6"/>
    <dbReference type="STRING" id="1460663.A0A177CFH6"/>
    <dbReference type="GeneID" id="28757961"/>
    <dbReference type="InParanoid" id="A0A177CFH6"/>
    <dbReference type="OrthoDB" id="62at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034657">
        <property type="term" value="C:GID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045721">
        <property type="term" value="P:negative regulation of gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007039">
        <property type="term" value="P:protein catabolic process in the vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018618">
        <property type="entry name" value="GID4/10-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14534:SF3">
        <property type="entry name" value="GID COMPLEX SUBUNIT 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14534">
        <property type="entry name" value="VACUOLAR IMPORT AND DEGRADATION PROTEIN 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09783">
        <property type="entry name" value="Vac_ImportDeg"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="94"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="206"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="395"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="552"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="42"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="208"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="245"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="552"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="571"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00061469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAG06364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="658" mass="74264" checksum="261174497E63090C" modified="2016-09-07" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CFV5</accession>
    <name>A0A177CFV5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CC84DRAFT_1244173</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG05709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036074.1">
        <property type="nucleotide sequence ID" value="XM_018184144.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CFV5"/>
    <dbReference type="STRING" id="1460663.A0A177CFV5"/>
    <dbReference type="GeneID" id="28767630"/>
    <dbReference type="InParanoid" id="A0A177CFV5"/>
    <dbReference type="OrthoDB" id="7464126at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056125">
        <property type="entry name" value="DUF7708"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054471">
        <property type="entry name" value="GPIID_WHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF14">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24809">
        <property type="entry name" value="DUF7708"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22939">
        <property type="entry name" value="WHD_GPIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="DUF7708" evidence="4">
        <location>
            <begin position="70"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="5">
        <location>
            <begin position="269"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="domain" description="GPI inositol-deacylase winged helix" evidence="3">
        <location>
            <begin position="561"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="884"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="884"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="922"/>
            <end position="934"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAG05709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="950" mass="108223" checksum="DE4A8A4A58ACFE4E" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CGA1</accession>
    <name>A0A177CGA1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Beta-xylosidase C-terminal Concanavalin A-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_1162974</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the glycosyl hydrolase 43 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG06615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036980.1">
        <property type="nucleotide sequence ID" value="XM_018178141.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CGA1"/>
    <dbReference type="STRING" id="1460663.A0A177CGA1"/>
    <dbReference type="GeneID" id="28761627"/>
    <dbReference type="InParanoid" id="A0A177CGA1"/>
    <dbReference type="OrthoDB" id="2139957at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09000">
        <property type="entry name" value="GH43_SXA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041542">
        <property type="entry name" value="GH43_C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006710">
        <property type="entry name" value="Glyco_hydro_43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051795">
        <property type="entry name" value="Glycosyl_Hydrlase_43"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42812">
        <property type="entry name" value="BETA-XYLOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42812:SF12">
        <property type="entry name" value="BETA-XYLOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17851">
        <property type="entry name" value="GH43_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04616">
        <property type="entry name" value="Glyco_hydro_43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-xylosidase C-terminal Concanavalin A-like" evidence="7">
        <location>
            <begin position="326"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="15"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="187"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate" evidence="5">
        <location>
            <position position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAG06615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="543" mass="61380" checksum="6DC624FEC042AB97" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CGJ0</accession>
    <name>A0A177CGJ0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1163025</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG06695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037060.1">
        <property type="nucleotide sequence ID" value="XM_018178155.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CGJ0"/>
    <dbReference type="GeneID" id="28761641"/>
    <dbReference type="InParanoid" id="A0A177CGJ0"/>
    <dbReference type="OrthoDB" id="408373at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG06695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="74" mass="8608" checksum="D121298A750F5225" modified="2016-09-07" version="1">MCTVTNPADRFYNDRTAQEQQKRIGMLLPNVVHTQTTPINYAACLHHPVTYLFSANDAALGWRCRNRWWRRSGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CGR6</accession>
    <name>A0A177CGR6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Kinase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1258028</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG06764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037129.1">
        <property type="nucleotide sequence ID" value="XM_018184791.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CGR6"/>
    <dbReference type="STRING" id="1460663.A0A177CGR6"/>
    <dbReference type="GeneID" id="28768277"/>
    <dbReference type="InParanoid" id="A0A177CGR6"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24359:SF1">
        <property type="entry name" value="INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE EPSILON SUBUNIT HOMOLOG 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24359">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE SBK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="169"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG06764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="525" mass="59532" checksum="1B1E4B8F788485AE" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CHA6</accession>
    <name>A0A177CHA6_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Citrate synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CC84DRAFT_1143166</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>oxaloacetate + acetyl-CoA + H2O = citrate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16845"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16947"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>propanoyl-CoA + oxaloacetate + H2O = (2S,3S)-2-methylcitrate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23780"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57392"/>
            <dbReference type="ChEBI" id="CHEBI:58853"/>
            <dbReference type="EC" id="2.3.3.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Organic acid metabolism; propanoate degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the citrate synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG06955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037320.1">
        <property type="nucleotide sequence ID" value="XM_018176397.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CHA6"/>
    <dbReference type="STRING" id="1460663.A0A177CHA6"/>
    <dbReference type="GeneID" id="28759883"/>
    <dbReference type="InParanoid" id="A0A177CHA6"/>
    <dbReference type="OrthoDB" id="8017587at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050440">
        <property type="term" value="F:2-methylcitrate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036440">
        <property type="term" value="F:citrate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019629">
        <property type="term" value="P:propionate catabolic process, 2-methylcitrate cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.580.10:FF:000001">
        <property type="entry name" value="Citrate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.580.10">
        <property type="entry name" value="Citrate Synthase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.230.10">
        <property type="entry name" value="Cytochrome P450-Terp, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016142">
        <property type="entry name" value="Citrate_synth-like_lrg_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016143">
        <property type="entry name" value="Citrate_synth-like_sm_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002020">
        <property type="entry name" value="Citrate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019810">
        <property type="entry name" value="Citrate_synthase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036969">
        <property type="entry name" value="Citrate_synthase_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007128">
        <property type="entry name" value="PRK09569.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11739">
        <property type="entry name" value="CITRATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11739:SF15">
        <property type="entry name" value="CITRATE SYNTHASE 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00285">
        <property type="entry name" value="Citrate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00143">
        <property type="entry name" value="CITRTSNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48256">
        <property type="entry name" value="Citrate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00480">
        <property type="entry name" value="CITRATE_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAG06955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="474" mass="51735" checksum="982130BADCF386AC" modified="2016-09-07" version="1">MALSARTASRALRAVKPSAARPFASVQSCSYSSSSEPDLKETFKKVLPAKRELLKKVKAHADKELGVVKVENTLGGMRGLKAMVWEGSVLDANEGIRFHGKTIKDCQKELPKGTSGTEMLPEAMFWLLLTGEVPTVSQTRVLSRELAEKAGIPKFVEKMLDDFPKDLHPMTQFACAVSALNYESKFAKAYEKGINKADYWEPTFDDCISLLAKLPTIAAKIYQNAYRGGGALPAEVDLNQDWAYNFAAMLGKAGKENEGFQDLLRLYLALHGDHEGGNVSAHATHLVGSALSDPFLSYSAGLQGLAGPLHGLAAQEVLRFILDMQKTVGTSFTEGDVTDFLWSVLKSGRVIPGYGHAVLRKPDPRFEALMDFANARPDIAKNPVYQLVKKNSEVAPGVLTEHGKTKNPYPNVDSSSGVLFHHYGFHETLYYTATFGVSRGLGPLAQLIWDRALGLPIERPKSINLEGILKQVGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CI27</accession>
    <name>A0A177CI27_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RCC1/BLIP-II</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1163244</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG06966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037331.1">
        <property type="nucleotide sequence ID" value="XM_018178213.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CI27"/>
    <dbReference type="STRING" id="1460663.A0A177CI27"/>
    <dbReference type="GeneID" id="28761699"/>
    <dbReference type="InParanoid" id="A0A177CI27"/>
    <dbReference type="OrthoDB" id="5370059at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051210">
        <property type="entry name" value="Ub_ligase/GEF_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22870:SF408">
        <property type="entry name" value="OS09G0560450 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22870">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG06966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="388" mass="42008" checksum="8AC2748523973D83" modified="2016-09-07" version="1">MDELYVFGYGYNQQFPKTLRQDAQKAEYLDVKSVSTPTCVLSAEEIVIVWASWCDLIIIISDTYRYTGTSLLPAQITAITTLPASLAQTPVFFGRPDTSGVLGFITPSRSTLTIFSTPHEIAQGAPPTQTTSFASSPRLILAIHFTASDAVIVHSAHRATNQITVVELPSLQHVHDFIANPNAEYITRTDFPLVQVTTNIATLTAVSQFGTTHTLATDRRFARAAGRDPDSSTETAQPVPFLEQTWITRVAAGGLYTAALAEDGELFLWGQAMAGTPGELRCLANKSDDDDEYVRTVDLGEGASVVDLAVGAGHVLVAVERGESREVWAAGDNRNHALGLGMEMKGRDFVNEFVAIEGLKGEWVKQMVCAGMSSYVVVKADSMRGNDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CIY7</accession>
    <name>A0A177CIY7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1088627</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG07276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037641.1">
        <property type="nucleotide sequence ID" value="XM_018174262.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CIY7"/>
    <dbReference type="GeneID" id="28757748"/>
    <dbReference type="InParanoid" id="A0A177CIY7"/>
    <dbReference type="OrthoDB" id="14339at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37332:SF1">
        <property type="entry name" value="ELMO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37332">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="116"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG07276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="528" mass="56563" checksum="A5E673E6C1AB4B99" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CJ94</accession>
    <name>A0A177CJ94_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_655767</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG07386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037751.1">
        <property type="nucleotide sequence ID" value="XM_018187030.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CJ94"/>
    <dbReference type="GeneID" id="28770516"/>
    <dbReference type="InParanoid" id="A0A177CJ94"/>
    <dbReference type="OrthoDB" id="5238025at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="223"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG07386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="273" mass="30213" checksum="128550EAD1FF3F28" modified="2016-09-07" version="1">MKKPELKMPSVLGKVSAKFVKKPMFNQPVHTEKRYHVTRMVYAVLLSLLVLIAASTIGLNAVTVNFIEDNRDTGFEFETEDPNDAVILAALPRMLYTAPAKLALVAGAISIFVGATHLAFVITDWKVGKKTQAYAFRRNMMFLHFGNTILILFALISTLVAHKSSSHVNVRYVTSKADRPSAADGLRYNIGTFDLETWSCEWKSIPGAEMVWMDYGAQCSVEVAGRSIMCLFLVVTTALAGLSIWGMIGRRDASGERIKTEQVELEMGKMNAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CJB8</accession>
    <name>A0A177CJB8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1174853</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG06958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037323.1">
        <property type="nucleotide sequence ID" value="XM_018180117.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CJB8"/>
    <dbReference type="GeneID" id="28763603"/>
    <dbReference type="InParanoid" id="A0A177CJB8"/>
    <dbReference type="OrthoDB" id="3748943at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="192"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="240"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG06958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="278" mass="30818" checksum="C6C5758F2506E2F4" modified="2016-09-07" version="1">MSASSRAARDAAEKRATCSFESTTPFGSTAPLNPVNPFETATPFDVVSPFDCTSPRKRWAPPGWELNTTITSHGLKASEIVLVDNCRCQDHRQRYPEVEAIIQMFFRVCAIILNVIVLIIVRILDTDLQTLLQVNRLYGGIAFSFLLNTIELLTLSNPQSTLLIHLFPSLLPAIPSKSSPELQPRFPRLPSLALCICELAAMTGSFCSAITFLNPKVEGDALRNGCPVVTCVTPEEHDMIYGYMIEAVIGLVHCGFFSMAFVHYAKRKGPGWLERLER</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CKD0</accession>
    <name>A0A177CKD0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_715307</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG07766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038131.1">
        <property type="nucleotide sequence ID" value="XM_018187135.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CKD0"/>
    <dbReference type="GeneID" id="28770621"/>
    <dbReference type="InParanoid" id="A0A177CKD0"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG07766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="155" mass="17047" checksum="2FE94C7D9C2504DE" modified="2016-09-07" version="1">MAHVNQLSTPRFWNVFVPVLGPFTPSAPVDCVHAGARAFCGTTPALGLTTSCPSVRFSSITHNTERSDTVPMVLFRRKNTSLVKGLAMPVLLQIESAVAFISAEPEILVQCRLGAKCTASTTFRLSCESSGWYSRHPGAVWFQPRIQLFPRRTRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CKD6</accession>
    <name>A0A177CKD6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">GMC oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_706347</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG07701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038066.1">
        <property type="nucleotide sequence ID" value="XM_018187121.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CKD6"/>
    <dbReference type="STRING" id="1460663.A0A177CKD6"/>
    <dbReference type="GeneID" id="28770607"/>
    <dbReference type="InParanoid" id="A0A177CKD6"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF115">
        <property type="entry name" value="DEHYDROGENASE XPTC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00623">
        <property type="entry name" value="GMC_OXRED_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008058285" evidence="5">
        <location>
            <begin position="22"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="6">
        <location>
            <begin position="117"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="7">
        <location>
            <begin position="309"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="554"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="597"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="127"/>
            <end position="130"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="268"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAG07701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="616" mass="65865" checksum="7F2077AB6A016F65" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CLG3</accession>
    <name>A0A177CLG3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CC84DRAFT_1185059</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038446.1">
        <property type="nucleotide sequence ID" value="XM_018180782.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CLG3"/>
    <dbReference type="FunCoup" id="A0A177CLG3">
        <property type="interactions" value="86"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CLG3"/>
    <dbReference type="GeneID" id="28764268"/>
    <dbReference type="InParanoid" id="A0A177CLG3"/>
    <dbReference type="OrthoDB" id="63267at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904828">
        <property type="term" value="P:positive regulation of hydrogen sulfide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060963">
        <property type="term" value="P:positive regulation of ribosomal protein gene transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045943">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045945">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901494">
        <property type="term" value="P:regulation of cysteine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032880">
        <property type="term" value="P:regulation of protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047484">
        <property type="term" value="P:regulation of response to osmotic stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090153">
        <property type="term" value="P:regulation of sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd11651">
        <property type="entry name" value="YPK1_N_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000008">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000116">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017892">
        <property type="entry name" value="Pkinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24351">
        <property type="entry name" value="RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00433">
        <property type="entry name" value="Pkinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="C2" evidence="12">
        <location>
            <begin position="156"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="351"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="14">
        <location>
            <begin position="613"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="209"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="695"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="10"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="80"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="124"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="144"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="157"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="241"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="716"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="380"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OAG08081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="748" mass="83555" checksum="97BC2DB395DDBD33" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CLH0</accession>
    <name>A0A177CLH0_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Only prolin and serin are matching in the corresponding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1089888</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG07627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037992.1">
        <property type="nucleotide sequence ID" value="XM_018174328.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CLH0"/>
    <dbReference type="GeneID" id="28757814"/>
    <dbReference type="InParanoid" id="A0A177CLH0"/>
    <dbReference type="OrthoDB" id="3882058at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="431"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="63"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG07627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="519" mass="56903" checksum="8CA488B2646AC490" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CM77</accession>
    <name>A0A177CM77_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_521957</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG07867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038232.1">
        <property type="nucleotide sequence ID" value="XM_018186613.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CM77"/>
    <dbReference type="STRING" id="1460663.A0A177CM77"/>
    <dbReference type="GeneID" id="28770099"/>
    <dbReference type="InParanoid" id="A0A177CM77"/>
    <dbReference type="OrthoDB" id="5386330at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540">
        <property type="entry name" value="TRANSCRIPTION FACTOR (ACR-2), PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540:SF5">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="124"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG07867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="227" mass="25173" checksum="DB3707E025F61EFF" modified="2016-09-07" version="1">MDDQNDSRAGSRSRRPPKRPQQFMFIDSTGANGVNAKPDKNVRSFVMKSARSKKPWSTRQKEKSTSPSEDKPQIPKRESSIAESISPTLVSPSWQHAAASPTTWSTPSNLSPVSSRNGSVLSTRSRSQPYLSPPSSSCSLCDNPQCVGDLCTQPHASNQLVIRRGFSVDFVANLDCLPVPTDSNTRDLLENCKTSYLVHVLHSLTLPRSRQHLRQWLRTGRPAPHLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CME1</accession>
    <name>A0A177CME1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">40S ribosomal protein S14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CC84DRAFT_1161974</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS11 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG07927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038292.1">
        <property type="nucleotide sequence ID" value="XM_018177873.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CME1"/>
    <dbReference type="FunCoup" id="A0A177CME1">
        <property type="interactions" value="1017"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CME1"/>
    <dbReference type="GeneID" id="28761359"/>
    <dbReference type="InParanoid" id="A0A177CME1"/>
    <dbReference type="OrthoDB" id="1677536at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.80:FF:000002">
        <property type="entry name" value="40S ribosomal protein S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.80">
        <property type="entry name" value="Ribosomal protein S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01310">
        <property type="entry name" value="Ribosomal_uS11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001971">
        <property type="entry name" value="Ribosomal_uS11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018102">
        <property type="entry name" value="Ribosomal_uS11_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036967">
        <property type="entry name" value="Ribosomal_uS11_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007176">
        <property type="entry name" value="PRK09607.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11759">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S14/30S RIBOSOMAL PROTEIN S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00411">
        <property type="entry name" value="Ribosomal_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002131">
        <property type="entry name" value="Ribosomal_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53137">
        <property type="entry name" value="Translational machinery components"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00054">
        <property type="entry name" value="RIBOSOMAL_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="128"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="142"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAG07927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="151" mass="16164" checksum="F4D308D9D4AA7737" modified="2016-09-07" version="1">MPPKKKVERGPAENIQLGPQVREGELVFGVARIFASFNDTFVHITDLSGRETISRVTGGMKVKADRDESSPYAAMLAAQDVAARCKELGITALHVKIRATGGNGTKTPGPGAQSALRALARAGMRIGRIEDVTPTPSDSTRRKGGRRGRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CP83</accession>
    <name>A0A177CP83_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1174398</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG09021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039386.1">
        <property type="nucleotide sequence ID" value="XM_018180093.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CP83"/>
    <dbReference type="STRING" id="1460663.A0A177CP83"/>
    <dbReference type="GeneID" id="28763579"/>
    <dbReference type="InParanoid" id="A0A177CP83"/>
    <dbReference type="OrthoDB" id="5385189at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG09021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="237" mass="26870" checksum="6A766493B0FEF1D9" modified="2016-09-07" version="1">MAHHIEDRWLWLGLGIFTFFAVKGVAHGLRRIVTLTEVHKSLPPIPPLRTEDAIKSSSLATLATCENVEIRKAATKILLDRFIAHPSAYKHLIRDANSRNEERKHAAYLAFSLLEDYGYVGHQYGVPPPMPATPQAHRLGARREWLRGGEGSTRAALNGDLEERDLRRRRREAMVIHEGDRPFSEEDVWMRDGEGRISTEEQAGPRNALEVWQASGDWLNPVTGELVRDAQTTRAER</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CPD3</accession>
    <name>A0A177CPD3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">UPF0057-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CC84DRAFT_1162610</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0057 (PMP3) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039105.1">
        <property type="nucleotide sequence ID" value="XM_018178039.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CPD3"/>
    <dbReference type="FunCoup" id="A0A177CPD3">
        <property type="interactions" value="1201"/>
    </dbReference>
    <dbReference type="GeneID" id="28761525"/>
    <dbReference type="InParanoid" id="A0A177CPD3"/>
    <dbReference type="OrthoDB" id="2802411at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000612">
        <property type="entry name" value="PMP3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21659">
        <property type="entry name" value="HYDROPHOBIC PROTEIN RCI2 LOW TEMPERATURE AND SALT RESPONSIVE PROTEIN LTI6 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21659:SF112">
        <property type="entry name" value="PROTEIN SNA2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01679">
        <property type="entry name" value="Pmp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="35"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAG08740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="71" mass="7909" checksum="80C7255A9DB00234" modified="2016-09-07" version="1">MSRPPSSTSDVLLYFLALFLPPVPVFLKRGCGADFLINICLSILGWIPGVLHAWYIISQTERNAARAATRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CPL4</accession>
    <name>A0A177CPL4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription initiation factor IIF subunit beta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">TFIIF medium subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">TFIIF-beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CC84DRAFT_1162586</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TFIIF beta subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039072.1">
        <property type="nucleotide sequence ID" value="XM_018178032.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CPL4"/>
    <dbReference type="FunCoup" id="A0A177CPL4">
        <property type="interactions" value="483"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CPL4"/>
    <dbReference type="GeneID" id="28761518"/>
    <dbReference type="InParanoid" id="A0A177CPL4"/>
    <dbReference type="OrthoDB" id="26094at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005674">
        <property type="term" value="C:transcription factor TFIIF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000035">
        <property type="entry name" value="General transcription factor IIF subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003196">
        <property type="entry name" value="TFIIF_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040450">
        <property type="entry name" value="TFIIF_beta_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040504">
        <property type="entry name" value="TFIIF_beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10445">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIF SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10445:SF0">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIF SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02270">
        <property type="entry name" value="TFIIF_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17683">
        <property type="entry name" value="TFIIF_beta_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TFIIF beta subunit N-terminal" evidence="12">
        <location>
            <begin position="36"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="TFIIF beta subunit HTH" evidence="11">
        <location>
            <begin position="265"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="74"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="155"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="335"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="156"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="342"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00081473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00081863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF17683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OAG08707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="358" mass="40754" checksum="4BC15B7818E47399" modified="2016-09-07" version="1">MMKTEGGSPSFGEGGYMDDEFYEDTGELSLPREGEKHVMIARIPDWLYDHLTTWDKFLAQPGDDNEKITLGEVLSLPPDNAYDRNKAQKDGKKPSVKREGPPEPPSMRIFFNSDWNKVTKLPTAYEIEGQTVNETLLKNTYVFTEKDLPGYKHNGAGQNKANPSNGAVQDPKARVKKSKYKKAIPKQTALIGSVNTQYLAKPLNTAEFIAFNTARTKEAIQGRNSSTNIMTEIVDEVTVMNNLQNHFDGFVRPDKKRKSQQNKFARLPRNELIDILHAAFDNHKYWPMRAIKQHTKQPEAYLKEVLPSLAVLIKSGPFASYWKRDDSYDRPSLHDGIADIKIEEEEDDEEDEEMEDVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CQ55</accession>
    <name>A0A177CQ55_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CC84DRAFT_1137480</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG09653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040018.1">
        <property type="nucleotide sequence ID" value="XM_018176149.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CQ55"/>
    <dbReference type="STRING" id="1460663.A0A177CQ55"/>
    <dbReference type="GeneID" id="28759635"/>
    <dbReference type="InParanoid" id="A0A177CQ55"/>
    <dbReference type="OrthoDB" id="4161332at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051615">
        <property type="entry name" value="Transcr_Regulatory_Elem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313:SF86">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="20"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="49"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="54"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAG09653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="734" mass="81850" checksum="9E93E8AE15F3ADB0" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CRM7</accession>
    <name>A0A177CRM7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fungal calcium binding protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1212862</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG09427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039792.1">
        <property type="nucleotide sequence ID" value="XM_018182484.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CRM7"/>
    <dbReference type="GeneID" id="28765970"/>
    <dbReference type="InParanoid" id="A0A177CRM7"/>
    <dbReference type="OrthoDB" id="4757933at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008058596" description="Fungal calcium binding protein domain-containing protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG09427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="110" mass="10871" checksum="136FE755CFB79380" modified="2016-09-07" version="1">MRFSATLPLLTAALALASPSPKPATNAMARDATTTVNEMTAAIQFAAQADCDVFQCANVVASTACIAAGIASGMIEAVLACVASGSTGICPCAACIPGLNDFLANNGICT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CRV1</accession>
    <name>A0A177CRV1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_475903</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040618.1">
        <property type="nucleotide sequence ID" value="XM_018186416.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CRV1"/>
    <dbReference type="STRING" id="1460663.A0A177CRV1"/>
    <dbReference type="GeneID" id="28769902"/>
    <dbReference type="InParanoid" id="A0A177CRV1"/>
    <dbReference type="OrthoDB" id="3686891at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="183"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="222"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG10253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="235" mass="27017" checksum="7E1BFCCB6156F140" modified="2016-09-07" version="1">MHTQEPAPTSNSRYGPFKARFSSSESASQHRKEATRFDRKPYRSPDTDYTISEVEKDRLYHVERVYNAMTCGDAARDNKGSIAMKRWVHGAYYESTLVEAYAHKVLDCLLLQAKEGFRGWVHNDYVADDRKGDDEDRDVTCEERLESILCALQEEKTICEDVMNSACQIRMFVNAPKAYANRKYQNRVGNSKRGRNKDSDPANRPSKTHAFDSKANHASCHHFNEPKPDSHHHLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CT10</accession>
    <name>A0A177CT10_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Ribophorin II</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Ribophorin-2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CC84DRAFT_1203058</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the SWP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041039.1">
        <property type="nucleotide sequence ID" value="XM_018181803.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CT10"/>
    <dbReference type="FunCoup" id="A0A177CT10">
        <property type="interactions" value="132"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CT10"/>
    <dbReference type="GeneID" id="28765289"/>
    <dbReference type="InParanoid" id="A0A177CT10"/>
    <dbReference type="OrthoDB" id="432292at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008250">
        <property type="term" value="C:oligosaccharyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055374">
        <property type="entry name" value="Ribophorin_II_3rd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056790">
        <property type="entry name" value="Ribophorin_II_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008814">
        <property type="entry name" value="Swp1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12640:SF0">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12640">
        <property type="entry name" value="RIBOPHORIN II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23860">
        <property type="entry name" value="Ribophorin_II_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25147">
        <property type="entry name" value="Ribophorin_II_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0732">Signal</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044224087" description="Ribophorin II" evidence="13">
        <location>
            <begin position="22"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="191"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="230"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="256"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="Ribophorin II third" evidence="14">
        <location>
            <begin position="30"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="Ribophorin II C-terminal" evidence="15">
        <location>
            <begin position="181"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00032139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF23860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF25147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OAG10674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="289" mass="30583" checksum="3B1C4D7378DD1889" modified="2016-09-07" version="1">MRFLRSLVPSLLVSSAAIVSAASSWSFEDATVTVSNKGAGVGAGAKDKLSATSPLSKSVSLGATDTLKLQLTTVDGKKATRPHQAFLTLTDPATGVEESFLLNVKDSGKGSLNLAHKDLPHQFLTSSKPLPASIVIGSFGSSTAYKAKVFDLNVARDPNVPLAVPEKPLRYAAEKEIHHIFRDDPRSPPKIITLIFAAAVAAALPALFIVWGTLGANANHLSKALGNAPIAHAVFFGSILAMEGIFFLYYTTWNLFQTLPAATVVGFVAFISGSRALSEVQERRLAGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CT38</accession>
    <name>A0A177CT38_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1084953</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041069.1">
        <property type="nucleotide sequence ID" value="XM_018174075.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CT38"/>
    <dbReference type="STRING" id="1460663.A0A177CT38"/>
    <dbReference type="GeneID" id="28757561"/>
    <dbReference type="InParanoid" id="A0A177CT38"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24359:SF1">
        <property type="entry name" value="INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE EPSILON SUBUNIT HOMOLOG 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24359">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE SBK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="69"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG10704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="402" mass="46194" checksum="738084D1AB7B8D38" modified="2016-09-07" version="1" fragment="single">MDDLELELEDLDSALPESDTLTARILESLCEGTASLKSSNGHVPFLPEGKIEHVFTKTKLTQELRRYDRSRVEKLGKNPCSDTYLNELSDWIYQHGKKVLAITLYCALDEADTMVAMGMFRKYNFGDNELPVGEFEEAPDHILKAFPQIKISSIGRNKTDIDSTWEREAVVLKEINKLGHPHITPCIAAIRRGDGRYFMFPWADGDNLRDFWDRTHSSPLTPELVRHAIGQLCGLAEALEQLHNIERNSSIHTKPIFEIPELERPSDSVFRIAGMGIAKKHIARANFREESTGPMFTTRRYEPPEATRVQSRLSDIWSMGCILFEYIIWLLYGNTVLKEFSREIDMDEGRYYETRVGGPHPEHAIRSVVRRWMEHIRKDPECSQHSAIRDLLDIVQNKLLVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CT52</accession>
    <name>A0A177CT52_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_492243</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041080.1">
        <property type="nucleotide sequence ID" value="XM_018186504.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CT52"/>
    <dbReference type="GeneID" id="28769990"/>
    <dbReference type="InParanoid" id="A0A177CT52"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008058562" description="Secreted protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG10715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="85" mass="9384" checksum="7791522AF6C4C028" modified="2016-09-07" version="1">MHPTRNFALTSHLALIGGHCATTGLLKSLVGGMLGVTAHSNRNEYSTRINGFRFCKVCCPHSLRSSSPVIDNRHDLCVHHRRCNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CTR2</accession>
    <name>A0A177CTR2_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">EKC/KEOPS complex subunit BUD32</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11 12">Atypical Serine/threonine protein kinase BUD32</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">EKC/KEOPS complex subunit bud32</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CC84DRAFT_497499</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. BUD32 has ATPase activity in the context of the EKC/KEOPS complex and likely plays a supporting role to the catalytic subunit KAE1. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. The complex is required for efficient recruitment of transcriptional coactivators.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Component of the EKC/KEOPS complex composed of at least BUD32, CGI121, GON7, KAE1 and PCC1; the whole complex dimerizes.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041278.1">
        <property type="nucleotide sequence ID" value="XM_018186542.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CTR2"/>
    <dbReference type="STRING" id="1460663.A0A177CTR2"/>
    <dbReference type="GeneID" id="28770028"/>
    <dbReference type="InParanoid" id="A0A177CTR2"/>
    <dbReference type="OrthoDB" id="310217at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050660">
        <property type="entry name" value="NEK_Ser/Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43671">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE NEK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43671:SF98">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE NEK11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 16" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="15"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00033194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OAG10913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="330" mass="36993" checksum="4BF44A219213A64F" modified="2016-09-07" version="1">MLEEICIRRRAGCKFELGSVLNHRWIIASSLSDHDNHASDSCTNRGIKLVQENSTGKWCILKMLPPDILRPGNAMREICVLQNLNRQGKTGHTNIVRLLDFADGCQHPHDIPWMVTELCDRGTLAQLVENYASQGVHLPEAFLWYAFERLAAAVQFCHNSGVVHRDITPTNIFLHSNTDMHTYPNLQLGDFGCAADEHYLLESTVEILSPGNPDFMPPEGYLVQASCDIYQVGLVVLCLCMRETDPTESLADFFNEMNTCGRQISTDLKRLIIWCLSREAAQRPSAEVLVASIDRIVSERQSNRKTFAFESLIEARNGMMASSNVAVPSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CTV9</accession>
    <name>A0A177CTV9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1084440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040582.1">
        <property type="nucleotide sequence ID" value="XM_018174054.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CTV9"/>
    <dbReference type="STRING" id="1460663.A0A177CTV9"/>
    <dbReference type="GeneID" id="28757540"/>
    <dbReference type="InParanoid" id="A0A177CTV9"/>
    <dbReference type="OrthoDB" id="3535086at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG10217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="118" mass="12917" checksum="27365E0345AADD44" modified="2016-09-07" version="1" fragment="single">KPPQQPARPSHAHQQTRTAHVTPPSAPPQSPGYTPTTAPQLKPRSQIEAMPPFSSSPLVPPRNVYDSAVRHPVFFTEQLRKAPFPIPTAATHGWNPVASGYIFEQRKAEANGIPKTKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CTW5</accession>
    <name>A0A177CTW5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1161787</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041350.1">
        <property type="nucleotide sequence ID" value="XM_018177837.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CTW5"/>
    <dbReference type="GeneID" id="28761323"/>
    <dbReference type="InParanoid" id="A0A177CTW5"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008058599" evidence="2">
        <location>
            <begin position="22"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG10985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="66" mass="7402" checksum="8B4EE06CEB9EAA95" modified="2016-09-07" version="1">MSNGHGILAAWICSMLIASQAALQYICISDWIYTCRTTPSVAWLTTIYITIIAKISCYMLEQRARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CUA0</accession>
    <name>A0A177CUA0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acid phosphatase/Vanadium-dependent haloperoxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CC84DRAFT_484908</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PA-phosphatase related phosphoesterase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040825.1">
        <property type="nucleotide sequence ID" value="XM_018186461.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CUA0"/>
    <dbReference type="STRING" id="1460663.A0A177CUA0"/>
    <dbReference type="GeneID" id="28769947"/>
    <dbReference type="InParanoid" id="A0A177CUA0"/>
    <dbReference type="OrthoDB" id="8907274at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008195">
        <property type="term" value="F:phosphatidate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046839">
        <property type="term" value="P:phospholipid dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006644">
        <property type="term" value="P:phospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03390">
        <property type="entry name" value="PAP2_containing_1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.144.10">
        <property type="entry name" value="Phosphatidic acid phosphatase type 2/haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043216">
        <property type="entry name" value="PAP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="PAP2/HPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="PAP2/HPO_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10165">
        <property type="entry name" value="LIPID PHOSPHATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10165:SF158">
        <property type="entry name" value="PAP2 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_4G08970)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="Acid phosphatase/Vanadium-dependent haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="74"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="208"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="238"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidic acid phosphatase type 2/haloperoxidase" evidence="8">
        <location>
            <begin position="131"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="316"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="373"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="487"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAG10460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="496" mass="54846" checksum="CD88A33CC296BA06" modified="2016-09-07" version="1">MDQWNTNKLPERLPFSKKRLPKRVIFSYILDYVVIFVLLAVFMLVDKIEPFHQPFALENWTLHYPYAKHERVTVTMAAVFAIGFPIVIITFYTMVIDGIFSHQTPMPAGRGGLKRLTGRYRLKDRLWELNCGLLGLMLSVGAAFTITGALKNAIGKPRPDIVDRCQVKEEVWKAFHDNYPRVVMATVADCMQSDNYILQDGFKSFPSAHSSVSFGGLFYLSIYLAAKLHVLDSKGEVWKSFIVLVPTLGAALIAGSRIMDARHHPFDVLSGSLMGILVAWGSYRQYFPPVSETWRKGRAYPIRAWGKGPAMPPPTAVIADDIQPLRPVRSATDEERGTSSAIPGADGHSGNVFRQQISQSQRRREEEFGGIQPSDTMSSTYSSKVAGYQGQLPASNPFTEASRRRQDNYEYSSSEDDDNIELQPSYSLSGRPLAGQRGANYDPVAGRLTDTGYHPPQGITPTPTPPPVRTTGDIAEARGGPAPPPAHAVGTTTQQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CWB0</accession>
    <name>A0A177CWB0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Ferric reductase-like protein transmembrane component 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CC84DRAFT_1080480</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG11844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042209.1">
        <property type="nucleotide sequence ID" value="XM_018173896.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CWB0"/>
    <dbReference type="STRING" id="1460663.A0A177CWB0"/>
    <dbReference type="GeneID" id="28757382"/>
    <dbReference type="InParanoid" id="A0A177CWB0"/>
    <dbReference type="OrthoDB" id="167398at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000293">
        <property type="term" value="F:ferric-chelate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015677">
        <property type="term" value="P:copper ion import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051410">
        <property type="entry name" value="Ferric/Cupric_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361:SF9">
        <property type="entry name" value="FERRIC REDUCTASE TRANSMEMBRANE COMPONENT 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361">
        <property type="entry name" value="FERRIC/CUPRIC REDUCTASE TRANSMEMBRANE COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00052">
        <property type="entry name" value="Ferric_Reductase_Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01168">
        <property type="entry name" value="Ferric_reductase_subgroup_(FRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="164"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="226"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="264"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="304"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="341"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="370"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="Ferric oxidoreductase" evidence="9">
        <location>
            <begin position="270"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="483"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="486"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="503"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAG11844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="673" mass="74893" checksum="2704C376A155BA03" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CX46</accession>
    <name>A0A177CX46_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Choline-sulfatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CC84DRAFT_1192417</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfatase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042490.1">
        <property type="nucleotide sequence ID" value="XM_018181247.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CX46"/>
    <dbReference type="STRING" id="1460663.A0A177CX46"/>
    <dbReference type="GeneID" id="28764733"/>
    <dbReference type="InParanoid" id="A0A177CX46"/>
    <dbReference type="OrthoDB" id="96314at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004065">
        <property type="term" value="F:arylsulfatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015024">
        <property type="term" value="F:glucuronate-2-sulfatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16032">
        <property type="entry name" value="choline-sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.720.10:FF:000032">
        <property type="entry name" value="Choline sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017785">
        <property type="entry name" value="Choline-sulfatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025863">
        <property type="entry name" value="Choline_sulf_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051849">
        <property type="entry name" value="GAG-degrading_sulfatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024607">
        <property type="entry name" value="Sulfatase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03417">
        <property type="entry name" value="chol_sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46615">
        <property type="entry name" value="ARYLSULFATASE K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46615:SF1">
        <property type="entry name" value="ARYLSULFATASE K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12411">
        <property type="entry name" value="Choline_sulf_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00149">
        <property type="entry name" value="SULFATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sulfatase N-terminal" evidence="4">
        <location>
            <begin position="106"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="domain" description="Choline sulfatase enzyme C-terminal" evidence="5">
        <location>
            <begin position="552"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="42"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="42"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="61"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAG12125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="629" mass="70450" checksum="D1BF2399244BE56E" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CX55</accession>
    <name>A0A177CX55_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Geranylgeranyl pyrophosphate synthetase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_67352</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042468.1">
        <property type="nucleotide sequence ID" value="XM_018187081.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CX55"/>
    <dbReference type="STRING" id="1460663.A0A177CX55"/>
    <dbReference type="GeneID" id="28770567"/>
    <dbReference type="InParanoid" id="A0A177CX55"/>
    <dbReference type="OrthoDB" id="420564at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35179:SF1">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35179">
        <property type="entry name" value="PROTEIN CBG02620"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG12103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="378" mass="41731" checksum="B7EC4AC8C07217C6" modified="2016-09-07" version="1">MMENVDSLVHTVSANEFALNDAIVSSVSGCETLCSYNWLKDGSGIVVPGGPPQWNPQPLPCTLPKDAGYSLEDAKAAKLPTYPYEPAFRALATMNPSTKFDDIDIVTRRNSLRKLLDFAAGKAIDPFRMDLHMVNDTLFISRKEASAAFMIHGAHNSGHGHNFETRFTKPGNGLNQSHSHHRVVRYLLGHLNCVVQFEVDAYYDDDDGRHSGPSQPQDPVEDAVASMANLSTRHARGSAFLAGAINVIHEGDLVDPAKLAELKLYGKNRRDPMPQIWFSRTPYLIEGRHVEGEVRSIRCTHVEAQFGTWEKDHQQALRKLVSLLDLLKSIVSGTENRSAILLCTDKGAPLTVFAAKNLGAVLPNDMTEMFWTVKDGVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CXD2</accession>
    <name>A0A177CXD2_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">5-demethoxyubiquinone hydroxylase, mitochondrial</fullName>
            <shortName evidence="8">DMQ hydroxylase</shortName>
            <ecNumber evidence="8">1.14.99.60</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Ubiquinone biosynthesis monooxygenase COQ7</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">COQ7</name>
        <name evidence="10" type="ORF">CC84DRAFT_1159561</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the hydroxylation of 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) during ubiquinone biosynthesis. Has also a structural role in the COQ enzyme complex, stabilizing other COQ polypeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a 5-methoxy-2-methyl-3-(all-trans-polyprenyl)benzene-1,4-diol + AH2 + O2 = a 3-demethylubiquinol + A + H2O</text>
            <dbReference type="Rhea" id="RHEA:50908"/>
            <dbReference type="Rhea" id="RHEA-COMP:10859"/>
            <dbReference type="Rhea" id="RHEA-COMP:10914"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:84167"/>
            <dbReference type="ChEBI" id="CHEBI:84422"/>
            <dbReference type="EC" id="1.14.99.60"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="8">Binds 2 iron ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Mitochondrion inner membrane</location>
            <topology evidence="8">Peripheral membrane protein</topology>
            <orientation evidence="8">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the COQ7 family.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.60" evidence="8"/>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042580.1">
        <property type="nucleotide sequence ID" value="XM_018177270.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CXD2"/>
    <dbReference type="FunCoup" id="A0A177CXD2">
        <property type="interactions" value="372"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CXD2"/>
    <dbReference type="GeneID" id="28760756"/>
    <dbReference type="InParanoid" id="A0A177CXD2"/>
    <dbReference type="OrthoDB" id="275371at2759"/>
    <dbReference type="UniPathway" id="UPA00232"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031314">
        <property type="term" value="C:extrinsic component of mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008682">
        <property type="term" value="F:3-demethoxyubiquinol 3-hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160224">
        <property type="term" value="F:3-demethoxyubiquinone 3-hydroxylase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01042">
        <property type="entry name" value="DMQH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01658">
        <property type="entry name" value="COQ7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011566">
        <property type="entry name" value="Ubq_synth_Coq7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11237:SF4">
        <property type="entry name" value="5-DEMETHOXYUBIQUINONE HYDROXYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11237">
        <property type="entry name" value="COENZYME Q10 BIOSYNTHESIS PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03232">
        <property type="entry name" value="COQ7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="Ferritin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0408">Iron</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="6 8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0830">Ubiquinone</keyword>
    <keyword evidence="2 8" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAG12215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="273" mass="30201" checksum="374C5CE819AB0DDB" modified="2016-09-07" version="1">MASALLATRPLARAAARSTQHPVAQFIVPCCIARPRRRIHSSPAHAVQSSPTKRSVAAAIPQDHADHSDLPTPHNTAAGTPIKLLSQEQHDFLDSALRVNQAGELAAVLIYAAQTPPLLRAHPHLKGLMKHMHDQEVGHFRYFNSILAKHRVRPTAMYPVWHAAATVLGWGTAVIGKEAAMACTEAVETEIGTHYNEQVRVLLDWADKLEARGETLGDELTVLIDELRRIRDEELEHLDHAVENDSKEAKPYELLTNVIRGGCRTAIWISERV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CYB6</accession>
    <name>A0A177CYB6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Hsp70 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1225645</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG11882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042247.1">
        <property type="nucleotide sequence ID" value="XM_018183572.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CYB6"/>
    <dbReference type="STRING" id="1460663.A0A177CYB6"/>
    <dbReference type="GeneID" id="28767058"/>
    <dbReference type="InParanoid" id="A0A177CYB6"/>
    <dbReference type="OrthoDB" id="2963168at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd10170">
        <property type="entry name" value="ASKHA_NBD_HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187">
        <property type="entry name" value="ALPHA KINASE/ELONGATION FACTOR 2 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187:SF82">
        <property type="entry name" value="FAMILY CHAPERONE, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G08575)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG11882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="559" mass="61830" checksum="E5158FBB87FCB68D" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CYD6</accession>
    <name>A0A177CYD6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ribosome recycling factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CC84DRAFT_57435</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Necessary for protein synthesis in mitochondria. Functions as a ribosome recycling factor in mitochondria.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RRF family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG11847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042212.1">
        <property type="nucleotide sequence ID" value="XM_018186724.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CYD6"/>
    <dbReference type="FunCoup" id="A0A177CYD6">
        <property type="interactions" value="76"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CYD6"/>
    <dbReference type="GeneID" id="28770210"/>
    <dbReference type="InParanoid" id="A0A177CYD6"/>
    <dbReference type="OrthoDB" id="407355at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.20">
        <property type="entry name" value="Ribosome-recycling factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002661">
        <property type="entry name" value="Ribosome_recyc_fac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023584">
        <property type="entry name" value="Ribosome_recyc_fac_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036191">
        <property type="entry name" value="RRF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20982:SF3">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOME RECYCLING FACTOR PSEUDO 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20982">
        <property type="entry name" value="RIBOSOME RECYCLING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01765">
        <property type="entry name" value="RRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55194">
        <property type="entry name" value="Ribosome recycling factor, RRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribosome recycling factor" evidence="5">
        <location>
            <begin position="102"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="61"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAG11847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="278" mass="29795" checksum="F757393B50062794" modified="2016-09-07" version="1">MAHTLLPRAAVRLSSQSSLLAATCATVTPCRQLFPRTPKTQGPARTFTCSPIVQKKAGKTNKANARTDSTPVSKAGTSTATDEAYDLSILESEILRAMEQLTHKLSQLRSGGRLNPEVVESLKVQLGSAGKDGDGKETVRLGDIAQVVPRGRTLNVLCGEAEHIKPVSTAIAASPHSLTPLTPEASTPLTIQVPLPPPTGETRRAAIQSASAAAELADKWIAKARQNHNQKLRKYQLDKTVLPDDLQKAGKRMEEVVKKGHSEVKRIVDGAKKVLEAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CYG8</accession>
    <name>A0A177CYG8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1159213</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG11759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042124.1">
        <property type="nucleotide sequence ID" value="XM_018177170.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CYG8"/>
    <dbReference type="STRING" id="1460663.A0A177CYG8"/>
    <dbReference type="GeneID" id="28760656"/>
    <dbReference type="InParanoid" id="A0A177CYG8"/>
    <dbReference type="OrthoDB" id="2152248at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47381">
        <property type="entry name" value="ALPHA/BETA-HYDROLASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47381:SF3">
        <property type="entry name" value="ALPHA_BETA-HYDROLASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG11759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="350" mass="37414" checksum="85CB6D463F3796D5" modified="2016-09-07" version="1">MAATNNPLEGHTADQPPVSTQTYTIAGIRTTVHGLTELPPATSTVACLWLLHPRLQTAKTMAPIATAILSAWNARIHAGRAGKSPTGLIAVSFDQRNHGTRLIDPLHNEAWRQGNPRHAQDMFGCIHGTAADTSQIMDHLASYIFTSPSSPQITQHFVLGISLGGHAAWHCVLAEPRITAAVVGIGCPDYTRLMVDRARLSKLDSYTASTPPGAAFLGSPDFPRALQDAVAQYDPAGLLLPGHFNPAGADPDVGKPATDRMKVLLRERLQGKRILNLSGKIDKLVPYAAGEAFLGAFKRALEEEPGLDIGFEDVLFEGVGHAFPAAMVEKSAEWICGLLENGQGQVSSKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CYJ2</accession>
    <name>A0A177CYJ2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Kinase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1200961</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG11789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042154.1">
        <property type="nucleotide sequence ID" value="XM_018181693.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CYJ2"/>
    <dbReference type="STRING" id="1460663.A0A177CYJ2"/>
    <dbReference type="GeneID" id="28765179"/>
    <dbReference type="InParanoid" id="A0A177CYJ2"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044773">
        <property type="term" value="P:mitotic DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167">
        <property type="entry name" value="OVARIAN-SPECIFIC SERINE/THREONINE-PROTEIN KINASE LOK-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167:SF24">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE CHK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="462"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="348"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG11789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="832" mass="94036" checksum="62F8B9D27290D0E1" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CYP3</accession>
    <name>A0A177CYP3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Splicing factor subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1159343</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the SF3B5 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG11930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042295.1">
        <property type="nucleotide sequence ID" value="XM_018177205.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CYP3"/>
    <dbReference type="FunCoup" id="A0A177CYP3">
        <property type="interactions" value="59"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CYP3"/>
    <dbReference type="GeneID" id="28760691"/>
    <dbReference type="InParanoid" id="A0A177CYP3"/>
    <dbReference type="OrthoDB" id="274726at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009846">
        <property type="entry name" value="SF3b5/RDS3-10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017089">
        <property type="entry name" value="Splicing_factor_3B_subunit_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20978">
        <property type="entry name" value="SPLICING FACTOR 3B SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20978:SF0">
        <property type="entry name" value="SPLICING FACTOR 3B SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07189">
        <property type="entry name" value="SF3b10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037010">
        <property type="entry name" value="Splicing_factor_3B_subunit_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR037010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG11930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="84" mass="9434" checksum="1DCB8FF1EBE21392" modified="2016-09-07" version="1">MADKLRAQQQLEALQARYIGIGSADTSKHEWTSNMARDSLASYVGHPPLLQYMSIGMGQPREKTRVQLLERMIQPVGPPPKQDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CZ09</accession>
    <name>A0A177CZ09_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UspA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1080408</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042435.1">
        <property type="nucleotide sequence ID" value="XM_018173892.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CZ09"/>
    <dbReference type="STRING" id="1460663.A0A177CZ09"/>
    <dbReference type="GeneID" id="28757378"/>
    <dbReference type="InParanoid" id="A0A177CZ09"/>
    <dbReference type="OrthoDB" id="992776at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23659">
        <property type="entry name" value="USP_At3g01520-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46100">
        <property type="entry name" value="IMP2'P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46100:SF4">
        <property type="entry name" value="USPA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UspA" evidence="2">
        <location>
            <begin position="421"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="209"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="489"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="162"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="213"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="249"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="349"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="500"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG12070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="640" mass="68589" checksum="857ABA094E0589C0" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CZG4</accession>
    <name>A0A177CZG4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Nucleotide-sugar transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CC84DRAFT_1211671</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042424.1">
        <property type="nucleotide sequence ID" value="XM_018182393.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CZG4"/>
    <dbReference type="STRING" id="1460663.A0A177CZG4"/>
    <dbReference type="GeneID" id="28765879"/>
    <dbReference type="InParanoid" id="A0A177CZG4"/>
    <dbReference type="OrthoDB" id="408493at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005459">
        <property type="term" value="F:UDP-galactose transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097624">
        <property type="term" value="P:UDP-galactose transmembrane import into Golgi lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007271">
        <property type="entry name" value="Nuc_sug_transpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00803">
        <property type="entry name" value="nst"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10231">
        <property type="entry name" value="NUCLEOTIDE-SUGAR TRANSMEMBRANE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04142">
        <property type="entry name" value="Nuc_sug_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005799">
        <property type="entry name" value="UDP-gal_transpt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="215"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="254"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="288"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="318"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="341"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="367"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="367"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="391"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAG12059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="408" mass="44062" checksum="502C331B8AB66988" modified="2016-09-07" version="1">MSNPNATFRGVPLKHLSLVTLVFQNSMLILIMHYSRIMPAVDGVRYHTSTSVFLNEVIKLSISATVALYDIAKNLPPGTPATTLFSTLFSNVFAGDSWKLAIPAAMYTLQNSLQYVAVSNLDAATFQVTYQLKILTTAIFSVIMLGRVLSVKKWAALGLLMAGVAIVQLPQYTPEPAVQESKAAEAKRWLHAIAGRSATYQGIGEDEGPIMNKSVGLMAVLIACALSGLAGVTFEKILKQSSSTKQASLWIRNCQLSFWSLFPAFFIGIVWVDGQNIATDGFFAGYNWIVWTAIGFQAAGGIIVALVINYADNIAKNFATSLSIIVSCVASAYFFDFEITLAFAVGTGVVLAATYLYTQPDAPKQTTIAPLEGTTTGDSEQAVPLMTRGRPSSDRESSDHMRPAEKPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CZS9</accession>
    <name>A0A177CZS9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Arad-like aldolase/epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1108663</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042715.1">
        <property type="nucleotide sequence ID" value="XM_018175203.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CZS9"/>
    <dbReference type="STRING" id="1460663.A0A177CZS9"/>
    <dbReference type="GeneID" id="28758689"/>
    <dbReference type="InParanoid" id="A0A177CZS9"/>
    <dbReference type="OrthoDB" id="3238794at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.225.10:FF:000009">
        <property type="entry name" value="Class II aldolase/adducin N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.225.10">
        <property type="entry name" value="Class II aldolase/adducin N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051017">
        <property type="entry name" value="Aldolase-II_Adducin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001303">
        <property type="entry name" value="Aldolase_II/adducin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036409">
        <property type="entry name" value="Aldolase_II/adducin_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004855">
        <property type="entry name" value="PRK06208.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10672">
        <property type="entry name" value="ADDUCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10672:SF41">
        <property type="entry name" value="CLASS II ALDOLASE_ADDUCIN DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_3G01330)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00596">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01007">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53639">
        <property type="entry name" value="AraD/HMP-PK domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Class II aldolase/adducin N-terminal" evidence="2">
        <location>
            <begin position="58"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG12350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="295" mass="31988" checksum="FA8ED7F38F0655A6" modified="2016-09-07" version="1">MSPPSATFEPHQDGGEKPSNAAPLEPGITQTEASVQKTKIPGPPKFDDPYKERAYLKGRLAAAFRIFGKFGFDEGVAGHITLRDPVDPATFWVNPFGVSFNLMKSSDLIHVNEEGEVIGGGECRLLNTAAYMIHSAIHQARPDVIAACHSHSIYGRSFCTLGRKLDTITQDSCAFHNDHVLYTSYKGVVLAKEEGENIAKKLGPHKAALLQNHGLLTVGHSIEEAVFWFVSMEKCCHAQLLADAAAAGRGGQTEKIAEEDAVFTSKTVGTHIAGWFSAKPLFDVIHKETGGDYLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177D0A6</accession>
    <name>A0A177D0A6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Release factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CC84DRAFT_1108724</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the prokaryotic/mitochondrial release factor family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042744.1">
        <property type="nucleotide sequence ID" value="XM_018175208.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177D0A6"/>
    <dbReference type="FunCoup" id="A0A177D0A6">
        <property type="interactions" value="699"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177D0A6"/>
    <dbReference type="GeneID" id="28758694"/>
    <dbReference type="InParanoid" id="A0A177D0A6"/>
    <dbReference type="OrthoDB" id="2019491at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003747">
        <property type="term" value="F:translation release factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070126">
        <property type="term" value="P:mitochondrial translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.20:FF:000070">
        <property type="entry name" value="Related to MRF1-peptide chain release factor, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1660">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005139">
        <property type="entry name" value="PCRF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000352">
        <property type="entry name" value="Pep_chain_release_fac_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045853">
        <property type="entry name" value="Pep_chain_release_fac_I_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050057">
        <property type="entry name" value="Prokaryotic/Mito_RF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43804">
        <property type="entry name" value="LD18447P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43804:SF7">
        <property type="entry name" value="LD18447P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03462">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00472">
        <property type="entry name" value="RF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00937">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75620">
        <property type="entry name" value="Release factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00745">
        <property type="entry name" value="RF_PROK_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0488">Methylation</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prokaryotic-type class I peptide chain release factors" evidence="4">
        <location>
            <begin position="276"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAG12379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="417" mass="45592" checksum="C544FFB8D4C71DCE" modified="2016-09-07" version="1">MLKTSWICRSCLARLARPAFGGQVRLQSSAAAPATVPPALLTRARGIALEHKHLTEKLASGFDTRAAKRVGECGPIVDALGAWEQAHESVAELTSLIQDPSSDAELRELAADDLGATREQLQTASQSLITSLVPVHPFAHLPCLLEIRPGAGGSEAAIFAGDLLRMYQGFCNRNGFRATLLKYENTNGTQEAGVPLSEAILEIDQENAYGVFRCEAGVHRVQRVPATEKSGRTHTSAASVHVLPSLQENSAASEDFDNPESDYYIDVKEVRLEVMRASGAGGQHVNKTESAVRLTHIPTNTVVSMQDSRSQIKNKEKAWALLRARIAQVRREKREEEMVAMRRSVVGVAKMGRGDKIRTYNYGQQRVTDHRSGTTVLNLDDVVAGGQALEDIMESVRTWLMEQDVKALVAEESETKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BTP0</accession>
    <name>A0A177BTP0_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MYND-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CC84DRAFT_1106128</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441567">
        <property type="protein sequence ID" value="OAF98535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018028901.1">
        <property type="nucleotide sequence ID" value="XM_018175126.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BTP0"/>
    <dbReference type="STRING" id="1460663.A0A177BTP0"/>
    <dbReference type="GeneID" id="28758612"/>
    <dbReference type="InParanoid" id="A0A177BTP0"/>
    <dbReference type="OrthoDB" id="5952526at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01360">
        <property type="entry name" value="ZF_MYND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="4">
        <location>
            <begin position="33"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAF98535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="357" mass="41754" checksum="9BA73B1313F521A9" modified="2016-09-07" version="1">MEDWSEEYRDYAQGEYYSDPSPFHISTKLIEGCSVCDKGGLLRCDACYVVHYCRRIHQYAHRKQHKSVCTKIKKAQQAKLRAGPDGAQDWAHPLEDRWPHRLWIIHPMRQYLTARFAVVKLQMKLNTRTAVQTALKNILDMLNERRQDDFYLRDLAPGLFLRLGCDQECYDFVKWWTCRFDPRKTDMDTPYVDIKDADMFEAPDIFMEDTRPHVVPLLAVMLLKIRLLINLTELQRVKREAGPYVPQEIQDLITIHVVSPVVAAKGESFQRENLVPPIHDLKRQIRRLYDAVHKANKYIWLAMVRPGNHLTAMPWYSGTGTIQEMQTKLPYIYNAWSESTGAIGVIEELQKETRSCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BVC8</accession>
    <name>A0A177BVC8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DUF829-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_393754</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Nucleus outer membrane</location>
            <topology evidence="6">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TMEM53 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441562">
        <property type="protein sequence ID" value="OAF99352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029718.1">
        <property type="nucleotide sequence ID" value="XM_018186032.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BVC8"/>
    <dbReference type="GeneID" id="28769518"/>
    <dbReference type="InParanoid" id="A0A177BVC8"/>
    <dbReference type="OrthoDB" id="77878at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005640">
        <property type="term" value="C:nuclear outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008547">
        <property type="entry name" value="DUF829_TMEM53"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12265">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12265:SF30">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05705">
        <property type="entry name" value="DUF829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="162"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAF99352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="277" mass="31606" checksum="0F55795FFCE0DD8E" modified="2016-09-07" version="1">MSNPTEAVKPLSEFHAIGEHVYLVTPKAYTSKEPLILFFSWMGAAPKHIAKYTVAYRKLFPTARLVLVRNELADFFRNEATYSRLLTPAIDVVKQHVDAGGQLLVHSFSNGGGNQLVEFAKAWTKREGSPLPMRAQMIDSAPGNGDWRRSHKAMSTSLPRFWLWRLLGSATIHLFLAMLFVIAKLGRREPIMNIMRRQLNDPALFNRQAPRVYLYSKADEMVGHDEVEEHADQAEAQGWKVTRIRFEKSPHAGHIRENEGRYWGAVQRAWEQGARVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BW41</accession>
    <name>A0A177BW41_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SAC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1223692</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441566">
        <property type="protein sequence ID" value="OAF98586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018028952.1">
        <property type="nucleotide sequence ID" value="XM_018183514.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BW41"/>
    <dbReference type="STRING" id="1460663.A0A177BW41"/>
    <dbReference type="GeneID" id="28767000"/>
    <dbReference type="InParanoid" id="A0A177BW41"/>
    <dbReference type="OrthoDB" id="405996at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002013">
        <property type="entry name" value="SAC_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02383">
        <property type="entry name" value="Syja_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAC" evidence="1">
        <location>
            <begin position="43"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAF98586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="102" mass="11067" checksum="9BC390816A22C15F" modified="2016-09-07" version="1">MPGLVCKLLIFAAAIKIDYKGNVGPLLKDRRQEEMAPGTLEVHGIIGLLKIATSYFLISICDCEQVAQIRSKPSYKITNVALIPLSSQADADKAITSARDHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BWQ0</accession>
    <name>A0A177BWQ0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1181286</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441561">
        <property type="protein sequence ID" value="OAF99832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030198.1">
        <property type="nucleotide sequence ID" value="XM_018180542.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BWQ0"/>
    <dbReference type="GeneID" id="28764028"/>
    <dbReference type="InParanoid" id="A0A177BWQ0"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="182"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAF99832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="495" mass="54336" checksum="78B9EB4E0AF53C61" modified="2016-09-07" version="1">MLHELVEGLGGITRRLVRHKCILERFIILGHEPVAVSTSAVRALGTREDIVVDAPRTERFDHDHTRDSVAFRLAPPINVASSPKVTASLMWTNSPNSAWKTLPVDDDASHHPRSNQRSEASLNTRRASQQNRNDDPIITHETNRKRLAYAVHGNKGQLGHDDHACAESSRHRAVAGLAESSFFLGGVVLSVGLLGMALVVVISPSTLRDFEAGGMSVALAVESLSGLHTIPVIAHASSVASLVTKVTRNVPGAWVEALDDVDSVCGRGCGRGCGRLNNRGLIDPDATLSDADNLSLRELARLVVFRLRTDGHNAGKHITASLLAGALSHEEGKRAAPDVTRGRLVPECIVEAGMPPILPTWPWEHNHRQYFVIRECVRRVPGTSVYHLAGGDRGGTADALRPGVGITALFESRWRQQKTPFRGDVGSPAATVREVGCCVGRRRRRCGVRLRVRRWVGLWTPREPVSRPYWVQRSVQGRCDRVRAATRRGRRWWTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BWW4</accession>
    <name>A0A177BWW4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1264557</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441563">
        <property type="protein sequence ID" value="OAF98997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029363.1">
        <property type="nucleotide sequence ID" value="XM_018185316.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BWW4"/>
    <dbReference type="GeneID" id="28768802"/>
    <dbReference type="InParanoid" id="A0A177BWW4"/>
    <dbReference type="OrthoDB" id="3793791at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008057411" evidence="2">
        <location>
            <begin position="18"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAF98997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="229" mass="26365" checksum="E0E39754DFABE42E" modified="2016-09-07" version="1">MRYTLAAFAMMASAVFAFPMALDTSAGHVAARGTANTNAVNWNEWKRNGGWKDYDTWKEYAEKYCPWKDEGYGSWDDWWNNDGYQWWRKISGDKSNKWSNGNDFDSWFKKDGYKTVDPWSKGSDSSSDWYQDENGVGWHKKDGKWVEDDDDSSSSWGKTDDSWSDGEDKPSWDGEDDDDNEWQVFKDETGQGWHKDQSSGKWEKDSSEDSGEWKKGADGKWSKGSSDSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BX86</accession>
    <name>A0A177BX86_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">AMP-activated protein kinase glycogen-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_393056</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441562">
        <property type="protein sequence ID" value="OAF99311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029677.1">
        <property type="nucleotide sequence ID" value="XM_018186023.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BX86"/>
    <dbReference type="STRING" id="1460663.A0A177BX86"/>
    <dbReference type="GeneID" id="28769509"/>
    <dbReference type="InParanoid" id="A0A177BX86"/>
    <dbReference type="OrthoDB" id="5350410at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02859">
        <property type="entry name" value="E_set_AMPKbeta_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="183"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="512"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="517"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="535"/>
            <end position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAF99311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="961" mass="106902" checksum="305E0F128F809B94" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BXI8</accession>
    <name>A0A177BXI8_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">AA9 family lytic polysaccharide monooxygenase</fullName>
            <ecNumber evidence="5">1.14.99.56</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Endo-beta-1,4-glucanase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Glycosyl hydrolase 61 family protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_402071</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Lytic polysaccharide monooxygenase (LMPO) that depolymerizes crystalline and amorphous polysaccharides via the oxidation of scissile alpha- or beta-(1-4)-glycosidic bonds, yielding C1 and/or C4 oxidation products. Catalysis by LPMOs requires the reduction of the active-site copper from Cu(II) to Cu(I) by a reducing agent and H(2)O(2) or O(2) as a cosubstrate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>[(1-&gt;4)-beta-D-glucosyl]n+m + reduced acceptor + O2 = 4-dehydro-beta-D-glucosyl-[(1-&gt;4)-beta-D-glucosyl]n-1 + [(1-&gt;4)-beta-D-glucosyl]m + acceptor + H2O.</text>
            <dbReference type="EC" id="1.14.99.56"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 5">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="5">Has a modular structure: an endo-beta-1,4-glucanase catalytic module at the N-terminus, a linker rich in serines and threonines, and a C-terminal carbohydrate-binding module (CBM).</text>
    </comment>
    <dbReference type="EC" id="1.14.99.56" evidence="5"/>
    <dbReference type="EMBL" id="KV441562">
        <property type="protein sequence ID" value="OAF99408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029774.1">
        <property type="nucleotide sequence ID" value="XM_018186046.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BXI8"/>
    <dbReference type="STRING" id="1460663.A0A177BXI8"/>
    <dbReference type="GeneID" id="28769532"/>
    <dbReference type="InParanoid" id="A0A177BXI8"/>
    <dbReference type="OrthoDB" id="6038816at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008810">
        <property type="term" value="F:cellulase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030248">
        <property type="term" value="F:cellulose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd21175">
        <property type="entry name" value="LPMO_AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049892">
        <property type="entry name" value="AA9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005103">
        <property type="entry name" value="AA9_LPMO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353:SF11">
        <property type="entry name" value="GLYCOSYLHYDROLASE FAMILY 61-7 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03443">
        <property type="entry name" value="AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="4 5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008057463" description="AA9 family lytic polysaccharide monooxygenase" evidence="6">
        <location>
            <begin position="21"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="Auxiliary Activity family 9 catalytic" evidence="7">
        <location>
            <begin position="21"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU368122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAF99408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="225" mass="23432" checksum="1A3600321A6D232E" modified="2016-09-07" version="1">MKFFSTAALAGALFLEAVNGHYIFQKLTANGVQGGVYQNIRQNTNNNSPVIDLASNDLRCNVGGGSGASTSTVSVAAGSTVTFTADIAVYHQGPVSFYLTKASSTAAASDGSTPWFKIKEIGPTFSGSSSTWDLEQSYSVTIPSCVPAGEYLLRIEQLAIHNPYPGGIPQFYISCAQIKVTGGGSKSFSGVSIPGHVKNTDPGYTANIYSGFTSYKVPGPAVSTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BXJ0</accession>
    <name>A0A177BXJ0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1223094</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441562">
        <property type="protein sequence ID" value="OAF99421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029787.1">
        <property type="nucleotide sequence ID" value="XM_018183462.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BXJ0"/>
    <dbReference type="GeneID" id="28766948"/>
    <dbReference type="InParanoid" id="A0A177BXJ0"/>
    <dbReference type="OrthoDB" id="3780398at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008057497" evidence="1">
        <location>
            <begin position="22"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAF99421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="146" mass="15392" checksum="804C5995347A81BF" modified="2016-09-07" version="1">MRLSSLLTLAAAGLTFLTVSAQDCWSSSRITCRNAFANKTAAHNAITAACDAMPSCAPGTTVTGKVPGYTATLRLGTACAGVNPWTKDACVALFEGKLYPQCKTNESLPYQEFPPKPWPPVAPVDFPLASKLSTCDDSWLSFNVGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BXV2</accession>
    <name>A0A177BXV2_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Exonuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CC84DRAFT_408109</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Exoribonuclease involved in ribosome biosynthesis. Involved in the processing of ITS1, the internal transcribed spacer localized between the 18S and 5.8S rRNAs.</text>
    </comment>
    <dbReference type="EMBL" id="KV441562">
        <property type="protein sequence ID" value="OAF99518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029884.1">
        <property type="nucleotide sequence ID" value="XM_018186078.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BXV2"/>
    <dbReference type="FunCoup" id="A0A177BXV2">
        <property type="interactions" value="71"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177BXV2"/>
    <dbReference type="GeneID" id="28769564"/>
    <dbReference type="InParanoid" id="A0A177BXV2"/>
    <dbReference type="OrthoDB" id="16516at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06137">
        <property type="entry name" value="DEDDh_RNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047021">
        <property type="entry name" value="REXO1/3/4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801:SF45">
        <property type="entry name" value="RNA EXONUCLEASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801">
        <property type="entry name" value="RNA EXONUCLEASE REXO1 / RECO3 FAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Exonuclease" evidence="6">
        <location>
            <begin position="165"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAF99518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="391" mass="43665" checksum="436A5386B6D284BB" modified="2016-09-07" version="1">MNMVAQSETYMMQLQLLMEPPGDLRRHGFITAPLTDEELLLKRRCLGCNKAMSQLRGRERTGPGLSISAHAANVAGAPQISASEFNGPAEKAATAPKFKCRFHPGKVEYKYWTCCDQHCTADPCSGSDFHNPRDESLMELTRRHQLHFTPIVHQDSLTRGQDLRAAVALDCEMGTAQSGDTELIKVSLIDYFTGEVLVNNIVEPDVPLRHLNTKYSGVTWGHMREAQRRRTILKATTGARYAVWRFVGEQTIVVGHGVHNDLRSMKWIHERVVDSFVIEFNIKRIREEKERIAEEEAIAKAKADGTYVEPVKETPVSGEGANRVVVPPVHKPRKRKGGDLSLKTLVDKRLGRKIQLGEGTTGHDSLEDAIAARDLVHWHINNPGANNSDAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BY68</accession>
    <name>A0A177BY68_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_345034</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441560">
        <property type="protein sequence ID" value="OAF99890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030256.1">
        <property type="nucleotide sequence ID" value="XM_018185864.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BY68"/>
    <dbReference type="GeneID" id="28769350"/>
    <dbReference type="InParanoid" id="A0A177BY68"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAF99890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="225" mass="25409" checksum="8E4D0C094633AADC" modified="2016-09-07" version="1">MCLIPLFREASRPLFRRAIIGSLYSAYSNTHGTISTTTHASSFRFTFYTFTFTQYTWILNTSLHSQHFIIMRSDLESRLSKIVGTSPKTKIENPPKYERVNSQYLESFVFGSASPRQQELLTIGEHFDDQRPPACDVNKALPPHPANRSRLLGARRVTLCVCASIFFILAITLALNISITIILRQHKNAHEDRSATLSPMLLEPFATIHGQMRGPTWTSGVPLVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BZ43</accession>
    <name>A0A177BZ43_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">6-methylsalicylate decarboxylase</fullName>
            <ecNumber evidence="7">4.1.1.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CC84DRAFT_1169145</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>6-methylsalicylate + H(+) = 3-methylphenol + CO2</text>
            <dbReference type="Rhea" id="RHEA:23112"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17231"/>
            <dbReference type="ChEBI" id="CHEBI:36658"/>
            <dbReference type="EC" id="4.1.1.52"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:23113"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-dependent hydrolases superfamily. ACMSD family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.52" evidence="7"/>
    <dbReference type="EMBL" id="KV441561">
        <property type="protein sequence ID" value="OAF99609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029975.1">
        <property type="nucleotide sequence ID" value="XM_018179583.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BZ43"/>
    <dbReference type="STRING" id="1460663.A0A177BZ43"/>
    <dbReference type="GeneID" id="28763069"/>
    <dbReference type="InParanoid" id="A0A177BZ43"/>
    <dbReference type="OrthoDB" id="2832284at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047596">
        <property type="term" value="F:6-methylsalicylate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032465">
        <property type="entry name" value="ACMSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240">
        <property type="entry name" value="2-AMINO-3-CARBOXYLMUCONATE-6-SEMIALDEHYDE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240:SF29">
        <property type="entry name" value="AMIDOHYDROLASE-RELATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="9">
        <location>
            <begin position="11"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00036832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAF99609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="323" mass="34019" checksum="2F7E704DDECAFE81" modified="2016-09-07" version="1">MGSIADIPQGIDVHHHFIPECYAKALHEAGGDPSGWKLPNWSVATSKALMQTHGIRTSILSLTAPGCSILQGAPAATLARAVNQEAHAIRNAHPTAFGFFAALPPVEADAAAAVAEIEHALDVLGADGVTLYTRYGPGPRYLGHADLRPVWAALNERKAVVFVHPTHAADTRPVNGALPQPIIDYPHETTRAAVDMILSGVLRDFPDVKIILSHAGGSLPYLATRAAHLLADAGLTALSADEFLTCAKSFYFDTALSGNALSLPLLLDFAPPGHVLFGSDFPYAPTPTIATHTVAGAEVLARREGEKGMDLAANALRLLPRLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BZX6</accession>
    <name>A0A177BZX6_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ankyrin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_245617</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441558">
        <property type="protein sequence ID" value="OAG00775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031140.1">
        <property type="nucleotide sequence ID" value="XM_018185653.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BZX6"/>
    <dbReference type="STRING" id="1460663.A0A177BZX6"/>
    <dbReference type="GeneID" id="28769139"/>
    <dbReference type="InParanoid" id="A0A177BZX6"/>
    <dbReference type="OrthoDB" id="20872at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG00775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="269" mass="29324" checksum="189D7EA0EF9EDCE1" modified="2016-09-07" version="1">MADAHKIILAACSSGDIYTLKTLFQEFHIGPDHPQSVYSLNQNLPEEEQLPVGERMFDHAIRGEQPGVIAFLSDHFSHYSLGGYSMQAAIDTCNTTVLRAVCKCDPASTSAELGDDSTINALGYAASKKNGAELVKVLLDGGADPNTTPPFKMPASWNLSAAILADLPVSTFEQFFDAGYQGNDPWAVKFAVEKKRADILEVLFARGKEFADAQFPAEKEMIAIANKDNDVTMVAAIKRGYTVLSKRRPERKSGLIASFMGKVRSRSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C0K8</accession>
    <name>A0A177C0K8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Dihydrodipicolinate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_1154748</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DapA family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441558">
        <property type="protein sequence ID" value="OAG01173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031538.1">
        <property type="nucleotide sequence ID" value="XM_018176909.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C0K8"/>
    <dbReference type="STRING" id="1460663.A0A177C0K8"/>
    <dbReference type="GeneID" id="28760395"/>
    <dbReference type="InParanoid" id="A0A177C0K8"/>
    <dbReference type="OrthoDB" id="191315at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008840">
        <property type="term" value="F:4-hydroxy-tetrahydrodipicolinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00408">
        <property type="entry name" value="DHDPS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002220">
        <property type="entry name" value="DapA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128">
        <property type="entry name" value="DIHYDRODIPICOLINATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128:SF47">
        <property type="entry name" value="DIHYDRODIPICOLINATE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00701">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001365">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00146">
        <property type="entry name" value="DHPICSNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01130">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton donor/acceptor" evidence="2">
        <location>
            <position position="155"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="2">
        <location>
            <position position="184"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR001365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR001365-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001365-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAG01173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="339" mass="36423" checksum="CE4609E5E7486FF7" modified="2016-09-07" version="1">MPIPKSTIPDKKTMLPPGVYTPVITLYKPTKAQEIDLDAMYTHCQFLVRGGQHGLVYSGTNGEAVLLSRSEKQDILRMARRAVTDLGVPSYPIVAGISGQSTNESIELAHDAAAAGASFGLLLPPSYWAKAVSEEALLGFYRDVADASPIPVVVYNFPAVTSGIDLNSDDLAALAAHPNIVAVKLTCMNVGKAIRLASKFSPQQFSVYGGSSDFLVPTLEGGGVGCVTGMGNVFPKSTARVYDLWTSGKKEEARALQEVVANAEWACKKSLALTKWAAGHFAGRQIGLDDAKTFFPRRPYLPAGEKMQQWTVEVMGVLEEEERKIEDKVFGGKAVNGVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C0R2</accession>
    <name>A0A177C0R2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_190634</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441557">
        <property type="protein sequence ID" value="OAG01384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031749.1">
        <property type="nucleotide sequence ID" value="XM_018185533.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C0R2"/>
    <dbReference type="GeneID" id="28769019"/>
    <dbReference type="InParanoid" id="A0A177C0R2"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG01384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="74" mass="8404" checksum="14DE629A47920251" modified="2016-09-07" version="1">MKSHQFYYLHIGLYALHYACPGSWLVNTSTKVADGAIQLCHLNYHYGFLASALAFIALYWAFPSAKVDEFVTQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C138</accession>
    <name>A0A177C138_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transmembrane 9 superfamily member</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CC84DRAFT_1154812</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441558">
        <property type="protein sequence ID" value="OAG01205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031570.1">
        <property type="nucleotide sequence ID" value="XM_018176910.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C138"/>
    <dbReference type="FunCoup" id="A0A177C138">
        <property type="interactions" value="15"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177C138"/>
    <dbReference type="GeneID" id="28760396"/>
    <dbReference type="InParanoid" id="A0A177C138"/>
    <dbReference type="OrthoDB" id="1666796at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072657">
        <property type="term" value="P:protein localization to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004240">
        <property type="entry name" value="EMP70"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10766:SF55">
        <property type="entry name" value="TRANSMEMBRANE 9 SUPERFAMILY MEMBER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10766">
        <property type="entry name" value="TRANSMEMBRANE 9 SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02990">
        <property type="entry name" value="EMP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="280"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="345"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="378"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="419"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="445"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="506"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="535"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="572"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="608"/>
            <end position="637"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAG01205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="647" mass="71846" checksum="086C400F6948DCB6" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C1B5</accession>
    <name>A0A177C1B5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_1221742</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441558">
        <property type="protein sequence ID" value="OAG01216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031581.1">
        <property type="nucleotide sequence ID" value="XM_018183298.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C1B5"/>
    <dbReference type="STRING" id="1460663.A0A177C1B5"/>
    <dbReference type="GeneID" id="28766784"/>
    <dbReference type="InParanoid" id="A0A177C1B5"/>
    <dbReference type="OrthoDB" id="47007at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48107:SF16">
        <property type="entry name" value="NADPH-DEPENDENT ALDEHYDE REDUCTASE 1, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48107">
        <property type="entry name" value="NADPH-DEPENDENT ALDEHYDE REDUCTASE-LIKE PROTEIN, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAG01216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="157" mass="17043" checksum="A9A088F43775296C" modified="2016-09-07" version="1">MACEAAKVAMNHLPAEEPVAKNAANFLAIEGFNITRIPGELLDEEFCSHLRLRAERALGRIDILVNNVGTGRDFTPDITIYTKKEWDRIFRTTVYAGFFLARAATPKMPPGPSIIWTVSSVVANLVSSIHGYAASKGAVASLVQTLRNFSEPAKAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2023-06-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C1H9</accession>
    <name>A0A177C1H9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_185570</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441557">
        <property type="protein sequence ID" value="OAG01286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031651.1">
        <property type="nucleotide sequence ID" value="XM_018185506.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C1H9"/>
    <dbReference type="GeneID" id="28768992"/>
    <dbReference type="InParanoid" id="A0A177C1H9"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG01286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="164" mass="17875" checksum="305D81E5BE5A4CA0" modified="2016-09-07" version="1">MSCCFPTLPYQSHPRRRAYTGGRGWSGSSSSTYRPGMHVTTPSNLAMSGLWPEEFHHGYTPTTAGHHTRSGRAQSSCPLRQRPANEVLDCGFACAVSWSCVFRVSVVVSGQRRGGGCDRLGGLMVFWGSDRCGGWARGSLADHDGRYHDDVHCGEVRQTRAGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2023-06-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C1T8</accession>
    <name>A0A177C1T8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1229292</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441558">
        <property type="protein sequence ID" value="OAG00778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031143.1">
        <property type="nucleotide sequence ID" value="XM_018183660.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C1T8"/>
    <dbReference type="GeneID" id="28767146"/>
    <dbReference type="InParanoid" id="A0A177C1T8"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG00778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="242" mass="25225" checksum="0DB6AA92BBE27715" modified="2016-09-07" version="1">MLPLSTPGQLGSRCTAGVDDLSPLGMHGPPIARTISRVARTLDPDWHLASWTPARPSWGWGSEHRAHISCERLHGGTASSRGTQARRTFANAEGATRGTCSRVPHAPLAQAVGATLTTNTTAQHICGPAGPSYRPSAAPRTGNPAEPRCRDAAPSCLLAQAGRCGGCVLSPPPASLVLMDPFHPGLTERRGPFVQTLCPSSPGSRRPATRCPRLHRSDTEPSADPSASRHSTGVQAPGTLAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C222</accession>
    <name>A0A177C222_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RNA-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_1155635</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441559">
        <property type="protein sequence ID" value="OAG00680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031045.1">
        <property type="nucleotide sequence ID" value="XM_018176946.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C222"/>
    <dbReference type="FunCoup" id="A0A177C222">
        <property type="interactions" value="175"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177C222"/>
    <dbReference type="GeneID" id="28760432"/>
    <dbReference type="InParanoid" id="A0A177C222"/>
    <dbReference type="OrthoDB" id="277802at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12246">
        <property type="entry name" value="RRM1_U1A_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000572">
        <property type="entry name" value="U1 small nuclear ribonucleoprotein A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051945">
        <property type="entry name" value="RRM_MRD1_RNA_proc_ribogen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48039">
        <property type="entry name" value="RNA-BINDING MOTIF PROTEIN 14B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48039:SF5">
        <property type="entry name" value="RNA-BINDING PROTEIN 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="24"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="140"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="152"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAG00680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="186" mass="20635" checksum="A9CF2E9DEDB52F7F" modified="2016-09-07" version="1">MASLARPPPPQGLPAKVHQTAPNRTLYVRNLPDKLPKEDLKRNLYMLFATYGVILDVVALKTPKMRGQAHVVFRDIDSSTQAMRALEGAAFFGKDMHIAYAKTKSDTIAKLDGTFKMPEPDLPEKQLETTEQTGVAATVFGSAPAKAVPVNEQERAKGTKRGREEEEKSESEDDDEEMQMSESDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C2J2</accession>
    <name>A0A177C2J2_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NACHT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1229758</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441558">
        <property type="protein sequence ID" value="OAG01082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031447.1">
        <property type="nucleotide sequence ID" value="XM_018183675.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C2J2"/>
    <dbReference type="STRING" id="1460663.A0A177C2J2"/>
    <dbReference type="GeneID" id="28767161"/>
    <dbReference type="InParanoid" id="A0A177C2J2"/>
    <dbReference type="OrthoDB" id="20872at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053137">
        <property type="entry name" value="NLR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082:SF6">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082">
        <property type="entry name" value="ATP/GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05729">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13374">
        <property type="entry name" value="TPR_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NACHT" evidence="2">
        <location>
            <begin position="110"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="388"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="401"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG01082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="682" mass="76453" checksum="687583EC2EA7273D" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C2W2</accession>
    <name>A0A177C2W2_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fungal N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1180282</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441558">
        <property type="protein sequence ID" value="OAG01239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031604.1">
        <property type="nucleotide sequence ID" value="XM_018180464.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C2W2"/>
    <dbReference type="STRING" id="1460663.A0A177C2W2"/>
    <dbReference type="GeneID" id="28763950"/>
    <dbReference type="InParanoid" id="A0A177C2W2"/>
    <dbReference type="OrthoDB" id="3800086at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="35"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG01239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="151" mass="16933" checksum="91C41F6299EBC1B7" modified="2016-09-07" version="1">MTDPFSLPTGSFAVVSVVEVLLETSVECCCFLNALKDAHEEIDRLCTSIEEYQALVEALKANSTEVQGHKMPPAQGTLHKALELFDSSVRLLHRQLSALRTLKTWHKSKWKTYNAFKFYLDDRKMSRCSKNLENAESARGTALGLVEGQVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C350</accession>
    <name>A0A177C350_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_981693</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441556">
        <property type="protein sequence ID" value="OAG02043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032408.1">
        <property type="nucleotide sequence ID" value="XM_018188042.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C350"/>
    <dbReference type="GeneID" id="28771528"/>
    <dbReference type="InParanoid" id="A0A177C350"/>
    <dbReference type="OrthoDB" id="4191440at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG02043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="534" mass="60331" checksum="871FBBA332B772FC" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C3K7</accession>
    <name>A0A177C3K7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Alcohol dehydrogenase 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CC84DRAFT_977415</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441556">
        <property type="protein sequence ID" value="OAG01986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032351.1">
        <property type="nucleotide sequence ID" value="XM_018188034.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C3K7"/>
    <dbReference type="STRING" id="1460663.A0A177C3K7"/>
    <dbReference type="GeneID" id="28771520"/>
    <dbReference type="InParanoid" id="A0A177C3K7"/>
    <dbReference type="OrthoDB" id="1560166at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000039">
        <property type="entry name" value="Alcohol dehydrogenase AdhP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940:SF7">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE-LIKE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="8">
        <location>
            <begin position="16"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAG01986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="338" mass="35875" checksum="0E419E91E3EDB529" modified="2016-09-07" version="1">MSLPQTYKQAVFKAQGQPLVIEEAPLKLPGKGELLVKVEACGVCFSDMFAQQNIMGGGFPMVPGHEIVGKVAAIGEGVELWKEGDRVGGGWHGGHDGVCKACKKGFFQMCDNQVINGETKAGGYAEYVLLRSEAAIRVPAHVDAAKYAPIMCAGLTCFNSIRNMNIGVGETVAVQGLGGLGHLAIQYAARFGYRVVAISRGGDKEAFARELGAHEYIDSSKGDAGEALQNLGGAKLVVTTSPSADVISPLLKGLGILGKLLILSVPGEVPVNTGVMLRYALTVQVWPCGSAVDAEDTIQFTELQDINCMIEKFPLDKANDAFNHMMSGKVRFRAVITM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C439</accession>
    <name>A0A177C439_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cora-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CC84DRAFT_1262235</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441556">
        <property type="protein sequence ID" value="OAG02265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032630.1">
        <property type="nucleotide sequence ID" value="XM_018185136.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C439"/>
    <dbReference type="STRING" id="1460663.A0A177C439"/>
    <dbReference type="GeneID" id="28768622"/>
    <dbReference type="InParanoid" id="A0A177C439"/>
    <dbReference type="OrthoDB" id="3761576at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046873">
        <property type="term" value="F:metal ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045863">
        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="241"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="274"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAG02265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="314" mass="34716" checksum="7F4D2473BDE06721" modified="2016-09-07" version="1">MRGERIGLIQHGCSVVIVDGPGEEWTGIVLLDAPISESYTALGFPPVHLASKLFFGGTEDFTTTPAGGVNGHDGNPTTVNNRGMLDELVHYWTQETPQSSTTSKPTLRDISYYPLKIVAAEWVNYIAVMGLSVREYELSTTLSGDLIAQLEKLNTNLRILQGWRRRVLSTQAKLRRTIRFIENHVDRKQPNRDWDVLVDDFEFICTGVAEHGERLEAMVSVVTSTAALIEGRRSLTETENVTRLTILAVVFLPLSYIASLFSMSDEIRPGGPHFWIYFAVAVPLTFIVGLIAKPPVSIAKRIAGTIGEKTASLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C449</accession>
    <name>A0A177C449_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1152045</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441556">
        <property type="protein sequence ID" value="OAG01941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032306.1">
        <property type="nucleotide sequence ID" value="XM_018176787.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C449"/>
    <dbReference type="STRING" id="1460663.A0A177C449"/>
    <dbReference type="GeneID" id="28760273"/>
    <dbReference type="InParanoid" id="A0A177C449"/>
    <dbReference type="OrthoDB" id="416441at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005674">
        <property type="entry name" value="CocE/Ser_esterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000383">
        <property type="entry name" value="Xaa-Pro-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013736">
        <property type="entry name" value="Xaa-Pro_dipept_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050585">
        <property type="entry name" value="Xaa-Pro_dipeptidyl-ppase/CocE"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00976">
        <property type="entry name" value="CocE_NonD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43056:SF10">
        <property type="entry name" value="COCE_NOND FAMILY, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G00600)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43056">
        <property type="entry name" value="PEPTIDASE S9 PROLYL OLIGOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02129">
        <property type="entry name" value="Peptidase_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08530">
        <property type="entry name" value="PepX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00939">
        <property type="entry name" value="PepX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xaa-Pro dipeptidyl-peptidase C-terminal" evidence="2">
        <location>
            <begin position="286"/>
            <end position="537"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG01941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="669" mass="75310" checksum="30408E5C5EE03115" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C4Q0</accession>
    <name>A0A177C4Q0_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Lysine-specific metallo-endopeptidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1262851</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441557">
        <property type="protein sequence ID" value="OAG01859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032224.1">
        <property type="nucleotide sequence ID" value="XM_018185182.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C4Q0"/>
    <dbReference type="GeneID" id="28768668"/>
    <dbReference type="InParanoid" id="A0A177C4Q0"/>
    <dbReference type="OrthoDB" id="4585232at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029463">
        <property type="entry name" value="Lys_MEP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14521">
        <property type="entry name" value="Aspzincin_M35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lysine-specific metallo-endopeptidase" evidence="2">
        <location>
            <begin position="188"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG01859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="300" mass="33976" checksum="0217A2CD7477853C" modified="2016-09-07" version="1">MPNEHLQDWTEMDHMFDSFGNGMSYLPERNKADIRFYCDDDDYGEGKRWTITPDDPDDPADVKNSLLPRTGPKTGPGSEGPFQQWQDTKNWIRMGRGHMGCKHPEPEDNRVMGIVHFRKFEVENMTPADINPDRCTVTLCDFKLSKTKYGVSEGEAPESEVDVADLQKYLDKDEISIQNSLEVHDALLSGTLLHELTHITKPGMDTDDHTYNYKKMIQLTSAQALDNAETYAIYAFIARLADFKFRVDNLDEGTIRYDKDLETVGGEDLMPDPVDLPRPPIIESGLRPGAEAMRDATIAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C4U1</accession>
    <name>A0A177C4U1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cysteine proteinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CC84DRAFT_896581</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C2 family. PalB/RIM13 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG02515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032880.1">
        <property type="nucleotide sequence ID" value="XM_018187824.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C4U1"/>
    <dbReference type="STRING" id="1460663.A0A177C4U1"/>
    <dbReference type="GeneID" id="28771310"/>
    <dbReference type="InParanoid" id="A0A177C4U1"/>
    <dbReference type="OrthoDB" id="167576at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004198">
        <property type="term" value="F:calcium-dependent cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00044">
        <property type="entry name" value="CysPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022682">
        <property type="entry name" value="Calpain_domain_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022683">
        <property type="entry name" value="Calpain_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036213">
        <property type="entry name" value="Calpain_III_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051297">
        <property type="entry name" value="PalB/RIM13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001300">
        <property type="entry name" value="Peptidase_C2_calpain_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46143">
        <property type="entry name" value="CALPAIN-7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46143:SF1">
        <property type="entry name" value="CALPAIN-7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01067">
        <property type="entry name" value="Calpain_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25435">
        <property type="entry name" value="PalB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00648">
        <property type="entry name" value="Peptidase_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00720">
        <property type="entry name" value="calpain_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00230">
        <property type="entry name" value="CysPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49758">
        <property type="entry name" value="Calpain large subunit, middle domain (domain III)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50203">
        <property type="entry name" value="CALPAIN_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0788">Thiol protease</keyword>
    <feature type="domain" description="Calpain catalytic" evidence="8">
        <location>
            <begin position="268"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="117"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="195"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="121"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="155"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="198"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="330"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="497"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAG02515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="1024" mass="113821" checksum="4EB6F4725106E9F8" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C537</accession>
    <name>A0A177C537_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1219689</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG02733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033098.1">
        <property type="nucleotide sequence ID" value="XM_018183100.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C537"/>
    <dbReference type="GeneID" id="28766586"/>
    <dbReference type="InParanoid" id="A0A177C537"/>
    <dbReference type="OrthoDB" id="3796753at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG02733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="186" mass="21144" checksum="BE9378BB97686EBC" modified="2016-09-07" version="1">MCRKRKYDAELPAEMVRGLERLENEVNRYQGENKELRERLKAAETEVTTLQDHVASHKNKLNGGDKKVRSAKDVAGKQEEKAKDAVREKQDPSLTKLCDDLRADLEVERAGRSNKRKDDSASDITVAVVPVELTISRGNFLTLSETLEISQATVAMQLQDWYDEWMKPDDPVKQVLGADFVDNEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C5E5</accession>
    <name>A0A177C5E5_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Glutamate decarboxylase</fullName>
            <ecNumber evidence="3 9">4.1.1.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CC84DRAFT_974476</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6 9">
            <text>L-glutamate + H(+) = 4-aminobutanoate + CO2</text>
            <dbReference type="Rhea" id="RHEA:17785"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:59888"/>
            <dbReference type="EC" id="4.1.1.15"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7 8">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the group II decarboxylase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.15" evidence="3 9"/>
    <dbReference type="EMBL" id="KV441556">
        <property type="protein sequence ID" value="OAG01900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032265.1">
        <property type="nucleotide sequence ID" value="XM_018188018.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C5E5"/>
    <dbReference type="STRING" id="1460663.A0A177C5E5"/>
    <dbReference type="GeneID" id="28771504"/>
    <dbReference type="InParanoid" id="A0A177C5E5"/>
    <dbReference type="OrthoDB" id="5152799at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004351">
        <property type="term" value="F:glutamate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006538">
        <property type="term" value="P:L-glutamate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000017">
        <property type="entry name" value="Glutamate decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.160:FF:000004">
        <property type="entry name" value="Glutamate decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010107">
        <property type="entry name" value="Glutamate_decarboxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01788">
        <property type="entry name" value="Glu-decarb-GAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43321">
        <property type="entry name" value="GLUTAMATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43321:SF6">
        <property type="entry name" value="GLUTAMATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="5 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 7 8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="7">
        <location>
            <position position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602129-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAG01900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="427" mass="48301" checksum="D6BF4EF42BDF0179" modified="2016-09-07" version="1">MVDAFSKNFIDYEEYPVSADIQNRCVSMIARLFNVPGDDDANAMGTSTIGSSEGIMLAVLAMKKLWANKRKAEGKPFDQPNIIMNSAVQVCWEKAARYFDVEERYVYCTADRYVIDPKEAVDLIDENTIGICSILGTTYTGEYEDTKAINDLLVERNIDVPIHVDAASGGFVAPFVNPGLEWDFRLEKVVSINVSGHKYGLVYPGVGWVVWRDPKFLPKELVFNINYLGADQASFTLNFSRGASQIIGQYYQMIRLGKRGYRRIMLNLTRTADYLSANLEELGFIILSQKSGEGLPLVAARLDEDLGKQYDEFAIAHQLRERGWVVPAYTMAPHSDKMKLMRVVVREDFTKSRCDALIADFKLALETLDSMDSKRIQHEKEHAAEFHMRRRSTLIGTAGPQIKKQATYHFNDDHSLQAKHDKSHPVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2023-06-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C5F3</accession>
    <name>A0A177C5F3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1014845</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441556">
        <property type="protein sequence ID" value="OAG02381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032746.1">
        <property type="nucleotide sequence ID" value="XM_018173368.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C5F3"/>
    <dbReference type="GeneID" id="28756854"/>
    <dbReference type="InParanoid" id="A0A177C5F3"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG02381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="251" mass="28587" checksum="AF83044AA33A9029" modified="2016-09-07" version="1">MTCAARRGSRPSLELKWTEEYFTVRRGNDRKLTQLVFYLFICHGTLQRSSPYKQSPNFESCFSCHRRDELPTRIGRASNPKKNSDTHIPRYVQEFMLSITQKRSTKSTPTKNRISGCLAIMVCPGTRNHPTDSRHFTDNEGPRRREIAWRVGAECWLKRGGWFSISPPNRLQEFARSGKVASSKNPRAIYIHPNLSSNDKPSLRGSTNLIQMNSGILTGRIVAEGLVEGMRLSLALLWPTAPRASIVRELR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C5I9</accession>
    <name>A0A177C5I9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1251913</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441556">
        <property type="protein sequence ID" value="OAG01950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032315.1">
        <property type="nucleotide sequence ID" value="XM_018184349.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C5I9"/>
    <dbReference type="STRING" id="1460663.A0A177C5I9"/>
    <dbReference type="GeneID" id="28767835"/>
    <dbReference type="InParanoid" id="A0A177C5I9"/>
    <dbReference type="OrthoDB" id="194443at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG01950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="354" mass="39782" checksum="09CFCDA9808A675F" modified="2016-09-07" version="1">MQLFKALGRGLKSTLESIASPLKYLGTTRSVGREGITHDLDFTIDLVDLPDLWTFLATHDVEAPARDFFYALDFTELMHRWDIIPMLNRTMATSTRPILPYTMYPHAPGLPVRFLVGLAQMPFDIHTNILVDDSPRFTPAFLARLTAPLALPNMTPEAFGALTKWLYTRDPPIFSCASELQHLCELWVAAAQLGIYLKANTLLRLGMELMTPGDRVADFGTARWVFSNTPAGSPLRGFVIVILAQRSQPNFAAPFQAGDVEIWKARTAFMGKLQHARKVLAFGTRNADGRVTLDFEKEKREGMGVGLGKLPMPAFLVWDEKVWNDRGQVVPDRFFVFPETEEFHEGLVGWLKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C5P8</accession>
    <name>A0A177C5P8_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF7730 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1262386</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441556">
        <property type="protein sequence ID" value="OAG02471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032836.1">
        <property type="nucleotide sequence ID" value="XM_018185149.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C5P8"/>
    <dbReference type="GeneID" id="28768635"/>
    <dbReference type="InParanoid" id="A0A177C5P8"/>
    <dbReference type="OrthoDB" id="3801532at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056632">
        <property type="entry name" value="DUF7730"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38790">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24864">
        <property type="entry name" value="DUF7730"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7730" evidence="1">
        <location>
            <begin position="29"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG02471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="331" mass="37030" checksum="0AD92E03FA3C758B" modified="2016-09-07" version="1">MGLTEKVERLNLAVREKPFESSASSHWTAQPRSGLLMLPLEIRKLVFDHLIGGPGICISENGRCAKGVEVPTRYRTLGGRPLITCDHRSENQGNPINALYLMLVCRQFYAEVTDMLYATSRFIFHDAIAFLRFSTRLSPPVLHKLRSITLEAGSSDSSFFERPLRYWSDVEAGHEDAHRLPSLAAEYFNEPYYPSLLSRCLREPEYHYDVRDPQVPSTWGAVCQDLGKMAGLRVLNVVVALESMLVCHKNSVFDEARGMSIDQGQAEGFIFAPLVEVKRALGGEAEVELVVDWATLDGESVFESLAAEVGINFARARIESWKKGMVLGANY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C5X3</accession>
    <name>A0A177C5X3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CC84DRAFT_988578</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC43A transporter (TC 2.A.1.44) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441556">
        <property type="protein sequence ID" value="OAG02127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032492.1">
        <property type="nucleotide sequence ID" value="XM_018188060.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C5X3"/>
    <dbReference type="FunCoup" id="A0A177C5X3">
        <property type="interactions" value="43"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177C5X3"/>
    <dbReference type="GeneID" id="28771546"/>
    <dbReference type="InParanoid" id="A0A177C5X3"/>
    <dbReference type="OrthoDB" id="330047at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052599">
        <property type="entry name" value="SLC43A_AATransporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20772">
        <property type="entry name" value="PROTEIN FMP42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20772:SF2">
        <property type="entry name" value="PROTEIN FMP42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="146"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="204"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="239"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="354"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="396"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="472"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="512"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAG02127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="582" mass="64247" checksum="371F2C70437F144B" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C640</accession>
    <name>A0A177C640_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_1219999</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG03093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033458.1">
        <property type="nucleotide sequence ID" value="XM_018183126.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C640"/>
    <dbReference type="STRING" id="1460663.A0A177C640"/>
    <dbReference type="GeneID" id="28766612"/>
    <dbReference type="InParanoid" id="A0A177C640"/>
    <dbReference type="OrthoDB" id="3903189at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF149">
        <property type="entry name" value="UBID FAMILY DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="116"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="158"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="195"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="225"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="24"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAG03093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="356" mass="39743" checksum="5A466671EFDABCFB" modified="2016-09-07" version="1">MHPSIFAAESWTLYALGVGLVLARLISRLSTLGSIRKLQLDDWTIILAVIPFTGMVFSANQTFDPNTSAKDTTRRLKMRFLLEELQMTTVWLIKACLLILYRRIFPATRSSAKRRLLLCISVYCLASYALTQALLPLWCSPMRNYWNPSTQNAQCHTYHHHSILVLAADTTTILLAFVLPIAFIPTPRKALQASLFLLGTCVLGTSILARYYVLVQPRSPMYIHWYTAEVTLMVLFANLPFLSSLFSTAVRARGRSVALSSWPREYVGARDGEGLRWQVRKGSAATAESAGSVGSRKEMWGSDGPAPLLEIEHDGVVADVPAVMIRRFSIRDSVEEVEVGRRERRPSGMGLLPPLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C6B3</accession>
    <name>A0A177C6B3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">p-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CC84DRAFT_1262213</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441556">
        <property type="protein sequence ID" value="OAG02230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032595.1">
        <property type="nucleotide sequence ID" value="XM_018185134.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C6B3"/>
    <dbReference type="STRING" id="1460663.A0A177C6B3"/>
    <dbReference type="GeneID" id="28768620"/>
    <dbReference type="InParanoid" id="A0A177C6B3"/>
    <dbReference type="OrthoDB" id="3783056at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050304">
        <property type="entry name" value="MT-severing_AAA_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015415">
        <property type="entry name" value="Spast_Vps4_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23074">
        <property type="entry name" value="AAA DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23074:SF83">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09336">
        <property type="entry name" value="Vps4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="4">
        <location>
            <begin position="193"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="42"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="44"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="84"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAG02230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="469" mass="52146" checksum="B8B87B1CF057D304" modified="2016-09-07" version="1">MLSFVYGADEFIYVLGACLLNYGSAIGAGMYQSATAGAPKQIAGKREASHHDDKEEVLSVPSTELPHTLNSAPPSGVEIQTAATSQKTSVSVQSQLNQSSHAPTRPASPKRAKLDWTRWTTAPRKPEQSETEWQETQLREQIRNLKVVFEDDDESILEMADVAGLDSVKAALDEFACFFLHFPHLTRNLRHRSATGILLFGPQGTGKTLLVKSFAKKYNLTVYDVRASAIMSKFVGESEKFVKALFKEVRANTPSVLLLDECDGLLCNPTRDTTQSHNYRLLQNELKNQWSDLMYSKDEVIIVGVTNKPHDIDMDGFGRRLSLKLHVALPNATGCQAILKGALDRLRHTLSDDEFSKLGALCHECGLSGYDIDCLVEGLLRSSLRKIVLSAHFQRLDWVEGTILVPCDEDADGALEGPYAHLVEHAEEVSYRPFTVDEVEHAIHRARPTVDEEMTQQHTMFASQYATED</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C6H2</accession>
    <name>A0A177C6H2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1253282</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441556">
        <property type="protein sequence ID" value="OAG02472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032837.1">
        <property type="nucleotide sequence ID" value="XM_018184387.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C6H2"/>
    <dbReference type="GeneID" id="28767873"/>
    <dbReference type="InParanoid" id="A0A177C6H2"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG02472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="247" mass="26869" checksum="CD80C402B0AF3664" modified="2016-09-07" version="1">MHQATDRRSEPHRRRRGARARHAKPAPTWTSRSRSGAHCSAKALYCYRPPATPAAAEQPQASLRSRRLSSVLDGLFLCCCAGAARSVSQVAPPASRTAAAAGHANPTRLLARPPSNTLQPASIVLSFGRPKQTSQTGWCVPRARSRWPVFPDALRAPLERVPAPYALTAFGAGPLEPAPMETRMTLICPLVASPWMAPQSPCPGNRRQLNTFRTFWNLVQYPSSIRTHGLNALLASVHSYSSPKVLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C8F5</accession>
    <name>A0A177C8F5_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">cAMP-dependent protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CC84DRAFT_1125374</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.11"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.11" evidence="1"/>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG03142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033507.1">
        <property type="nucleotide sequence ID" value="XM_018175716.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C8F5"/>
    <dbReference type="STRING" id="1460663.A0A177C8F5"/>
    <dbReference type="GeneID" id="28759202"/>
    <dbReference type="InParanoid" id="A0A177C8F5"/>
    <dbReference type="OrthoDB" id="63267at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005952">
        <property type="term" value="C:cAMP-dependent protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004691">
        <property type="term" value="F:cAMP-dependent protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd05580">
        <property type="entry name" value="STKc_PKA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000005">
        <property type="entry name" value="cAMP-dependent protein kinase catalytic subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000822">
        <property type="entry name" value="cAMP-dependent protein kinase catalytic subunit, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353:SF37">
        <property type="entry name" value="CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-DEPENDENT PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="77"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="13">
        <location>
            <begin position="340"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="14"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OAG03142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="397" mass="45710" checksum="12A3DC680487DB2D" modified="2016-09-07" version="1">MAAAVHKLLHPHRSRDQAREEEHERQHSATERARDEEKHTLAQWGEKKAPLEPGQIDKDPDQKMVGHSSSVLRKEDFELIKTLGTGTFARVWLVRVKNARDGEENQVFALKILRKMDVIRLKQVEHVRNERNVLAAVAGHPFITTMVASFQDHDSLYMLLDYCPGGEVFSYLRRARRFNEPTSQFYAAEIVLILEFLHEREGVAYRDLKPENILIDAEGHLKLVDFGFAKKVENRETYTLCGTPEYLAPEVIRNTGHGTAVDWWAFGILVYEFLVGQPPFWDQNPMKIYEQIVEGRVRFPSAMSADARDLISGLCTVDTSKRLGNISGGASTVKSHAWFKDIDWDALYHRKVQGPIVPHLRGPADTRNFDEYEPESIHREAYTKDMQEKYEDSFEDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C908</accession>
    <name>A0A177C908_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Beta-lactamase/transpeptidase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1151854</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the beta-lactamase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG03342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033707.1">
        <property type="nucleotide sequence ID" value="XM_018176769.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C908"/>
    <dbReference type="STRING" id="1460663.A0A177C908"/>
    <dbReference type="GeneID" id="28760255"/>
    <dbReference type="InParanoid" id="A0A177C908"/>
    <dbReference type="OrthoDB" id="10250282at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="entry name" value="DD-peptidase/beta-lactamase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051478">
        <property type="entry name" value="Beta-lactamase-like_AB/R"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22935:SF95">
        <property type="entry name" value="BETA-LACTAMASE-LIKE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22935">
        <property type="entry name" value="PENICILLIN-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="beta-lactamase/transpeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase-related" evidence="2">
        <location>
            <begin position="9"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG03342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="510" mass="55538" checksum="B3AB85103A195E90" modified="2016-09-07" version="1">MNESLSCGAQKKVTSDSIYRINSISKNFASFSALAVENLAKARIDVPFELTLDSPVRQLLPQFRLPDKDWIDGGRDITLRMLASHSSGLSREGYSTDFNMVLATGKADAETIGAKWAAATPEGNIEYAAKTNLMFAPGQRAGYSNLGMSILASSVVNYYNKITGSNLNWSQLTMQQILSPLNMTHSFFGSIPDSLLPDVGVPGGPNWADLVVGLGYDPAAGMWSSANDLTKYLYNIWLRPDPLPLISLSQRRRALQPNVALPDGKQLVGPGWEIDLFEVPISADASALNKTYSAYGKAGDGGGWHSWIDVIPELGYGLVVLTQVSGSADYVSISPSALKSVAHQHLMPAFAEALTSQMEKRFAGWYGDGEDGGLITEEVAKNETNATSYAKLELEGQVLYLRELVVNGTSALEGLDRLGWTDDYQVRYFSTPAGVALTPAEGAAENDEFGPGTQVWRMMIPGLEFCDWFDFDGYLDNNAWPLVKIAFVESGNGIDLHYPPFDIILSRVKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C9M7</accession>
    <name>A0A177C9M7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1165690</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG03457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033822.1">
        <property type="nucleotide sequence ID" value="XM_018178775.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C9M7"/>
    <dbReference type="GeneID" id="28762261"/>
    <dbReference type="InParanoid" id="A0A177C9M7"/>
    <dbReference type="OrthoDB" id="3776815at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008057984" evidence="2">
        <location>
            <begin position="17"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="217"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG03457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="264" mass="27819" checksum="C3A0C9A408830CB2" modified="2016-09-07" version="1">MRATVVLFLLAATASANITTSYFLPNVSYGTNRLRFVASVINASSDLVTLSVDLDNDPDYSEFGIKQGNWTMGSTMFEYSTSALMYGPSISDGGYAYSLRCDIPASSAVCTVTRGPDLVRPSCRLANRTNIGIPSEERKYTQLYSFSDTDSVGVETIVRTFPGFSSRPNPEWCGTETDIRNISVPSSALVETYPQARSDFNAYQFIITAGEEKLPKATTGGAASTGSLAPTGTGGGGTGSEGAAPMKTLAPALAGLGAAVAWFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C9P7</accession>
    <name>A0A177C9P7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ankyrin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_1164860</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG04373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034738.1">
        <property type="nucleotide sequence ID" value="XM_018178584.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C9P7"/>
    <dbReference type="STRING" id="1460663.A0A177C9P7"/>
    <dbReference type="GeneID" id="28762070"/>
    <dbReference type="InParanoid" id="A0A177C9P7"/>
    <dbReference type="OrthoDB" id="539213at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051165">
        <property type="entry name" value="Multifunctional_ANK_Repeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24123">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24123:SF33">
        <property type="entry name" value="PROTEIN HOS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="415"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="450"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAG04373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="523" mass="57784" checksum="15BB29673759FD2A" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C9U5</accession>
    <name>A0A177C9U5_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NAD(+) diphosphatase</fullName>
            <ecNumber evidence="4">3.6.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CC84DRAFT_1147014</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a 5'-end NAD(+)-phospho-ribonucleoside in mRNA + H2O = a 5'-end phospho-adenosine-phospho-ribonucleoside in mRNA + beta-nicotinamide D-ribonucleotide + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:60876"/>
            <dbReference type="Rhea" id="RHEA-COMP:15698"/>
            <dbReference type="Rhea" id="RHEA-COMP:15719"/>
            <dbReference type="ChEBI" id="CHEBI:14649"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:144029"/>
            <dbReference type="ChEBI" id="CHEBI:144051"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:60877"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Nudix hydrolase family. NudC subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.22" evidence="4"/>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG04423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034788.1">
        <property type="nucleotide sequence ID" value="XM_018176575.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C9U5"/>
    <dbReference type="FunCoup" id="A0A177C9U5">
        <property type="interactions" value="91"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177C9U5"/>
    <dbReference type="GeneID" id="28760061"/>
    <dbReference type="InParanoid" id="A0A177C9U5"/>
    <dbReference type="OrthoDB" id="10249612at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000210">
        <property type="term" value="F:NAD+ diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035529">
        <property type="term" value="F:NADH pyrophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019677">
        <property type="term" value="P:NAD+ catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110155">
        <property type="term" value="P:NAD-cap decapping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006742">
        <property type="term" value="P:NADP+ catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03429">
        <property type="entry name" value="NUDIX_NADH_pyrophosphatase_Nudt13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000042">
        <property type="entry name" value="Probable NADH pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050241">
        <property type="entry name" value="NAD-cap_RNA_hydrolase_NudC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015375">
        <property type="entry name" value="NADH_PPase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049734">
        <property type="entry name" value="NudC-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42904:SF6">
        <property type="entry name" value="NAD-CAPPED RNA HYDROLASE NUDT12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42904">
        <property type="entry name" value="NUDIX HYDROLASE, NUDC SUBFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09296">
        <property type="entry name" value="NUDIX-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="10">
        <location>
            <begin position="246"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OAG04423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="408" mass="44732" checksum="6BFBA17F4D351F7F" modified="2016-09-07" version="1">MPLPQPDLPEPAHPEVDSMLSRKFGKEIANYFSGSPLNRVSFLRPDHTFLSQAIRHPSTKILLFNKLEPLVHPPTSIATQSFADVTSIVGSDPFSKSEADTIADYNSSTYVPQIIFLGLDERHEGLVYKEHYKGVPWFAVDVTPKGALAENFEKLIQKVTAEGKEFSKGRMHLSLPPEEAAIYAEARHLLDWNARNPFCAACGYPTLSTHAGFKRTCPPEDIAPSVLNPVRPPCATRTGISNLCFPRTDPTVIMAVVSADGQRMLLGRQKRWPPHWYSTLAGFLEPAESVEEAVRREVWEESGVHLGRVVIHSTQPWPYPANLMIGAIGQAIPGGEDIHLGHDAELEDAKWFTADELREALRVGTSGLGEEPGPEYKEGGLRLPPATAIAHQLVTAVANGFASGAPMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CA46</accession>
    <name>A0A177CA46_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Signal recognition particle 54 kDa protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CC84DRAFT_1093450</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Signal-recognition-particle (SRP) assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum (ER) membrane. SRP is required for the cotranslational protein translocation for ER import and preferentially recognizes strongly hydrophobic signal sequences. It is involved in targeting the nascent chain-ribosome (RNC) complex to the ER and is proposed to participate in the arrest of nascent chain elongation during membrane targeting. SRP54 binds to the signal sequence of presecretory protein when they emerge from the ribosomes. SRP54 interacts with the scR1 RNA and mediates the association of the resulting SRP-RNC complex with the signal recognition particle receptor (SR) via its alpha subunit SRP101. Both, SRP54 and SRP101, are locked in their GTP bound forms in the SRP-RNC-SR complex, which dissociates upon transferring the signal sequence to the protein-conducting channel (translocon). After signal sequence transfer, SRP54 and SRP101 act as reciprocal GTPase-activating proteins (GAPs), thereby resolving their association.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.4"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="13">Fungal signal recognition particle consists of a 7S RNA molecule (scR1) and at least six protein subunits: srp72, srp68, srp54, sec65, srp21 and srp14.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 13">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 13">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="13">The M domain binds the 7SL RNA and the signal sequence of presecretory proteins.</text>
    </comment>
    <comment type="domain">
        <text evidence="13">The NG domain, also named G domain, is a special guanosine triphosphatase (GTPase) domain, which binds GTP and forms a guanosine 5'-triphosphate (GTP)-dependent complex with a homologous NG domain in the SRP receptor subunit srp101. The two NG domains undergo cooperative rearrangements upon their assembly, which culminate in the reciprocal activation of the GTPase activity of one another. SRP receptor compaction upon binding with cargo-loaded SRP and GTPase rearrangement drive SRP-mediated cotranslational protein translocation into the ER.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the GTP-binding SRP family. SRP54 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG04455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034820.1">
        <property type="nucleotide sequence ID" value="XM_018174512.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CA46"/>
    <dbReference type="FunCoup" id="A0A177CA46">
        <property type="interactions" value="977"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CA46"/>
    <dbReference type="GeneID" id="28757998"/>
    <dbReference type="InParanoid" id="A0A177CA46"/>
    <dbReference type="OrthoDB" id="10250817at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005786">
        <property type="term" value="C:signal recognition particle, endoplasmic reticulum targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030942">
        <property type="term" value="F:endoplasmic reticulum signal peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006616">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane, translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17875">
        <property type="entry name" value="SRP54_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.260.30:FF:000003">
        <property type="entry name" value="Signal recognition particle 54 kDa protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000022">
        <property type="entry name" value="Signal recognition particle 54 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.140:FF:000001">
        <property type="entry name" value="Signal recognition particle GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.140">
        <property type="entry name" value="Signal recognition particle SRP54, nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.30">
        <property type="entry name" value="Signal recognition particle, SRP54 subunit, M-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00306">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036891">
        <property type="entry name" value="Signal_recog_part_SRP54_M_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013822">
        <property type="entry name" value="Signal_recog_particl_SRP54_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004125">
        <property type="entry name" value="Signal_recog_particle_SRP54_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022941">
        <property type="entry name" value="SRP54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006325">
        <property type="entry name" value="SRP54_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000897">
        <property type="entry name" value="SRP54_GTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042101">
        <property type="entry name" value="SRP54_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01425">
        <property type="entry name" value="SRP54_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11564">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 54K PROTEIN SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11564:SF5">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE SUBUNIT SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00448">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02881">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02978">
        <property type="entry name" value="SRP_SPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00962">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00963">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47446">
        <property type="entry name" value="Signal peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00300">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 13" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 13" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 13" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="8 13" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="10 13" id="KW-0733">Signal recognition particle</keyword>
    <feature type="domain" description="SRP54-type proteins GTP-binding" evidence="14">
        <location>
            <begin position="269"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU364034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS00300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OAG04455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="545" mass="58208" checksum="645993A252CF7EEA" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CA73</accession>
    <name>A0A177CA73_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Acyl-CoA dehydrogenase NM domain-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CC84DRAFT_1196749</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG04644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035009.1">
        <property type="nucleotide sequence ID" value="XM_018181486.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CA73"/>
    <dbReference type="STRING" id="1460663.A0A177CA73"/>
    <dbReference type="GeneID" id="28764972"/>
    <dbReference type="InParanoid" id="A0A177CA73"/>
    <dbReference type="OrthoDB" id="10254877at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033539">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA dehydrogenase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050741">
        <property type="entry name" value="Acyl-CoA_dehydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083:SF28">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G10880)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083">
        <property type="entry name" value="MEDIUM-CHAIN SPECIFIC ACYL-COA DEHYDROGENASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0274">FAD</keyword>
    <keyword evidence="3 6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase N-terminal" evidence="9">
        <location>
            <begin position="31"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="8">
        <location>
            <begin position="157"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="7">
        <location>
            <begin position="264"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAG04644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="432" mass="47701" checksum="5A9BF06848E0E811" modified="2016-09-07" version="1">MAPDTKATTVNDGPPWSEPSWLTLPSPYYNESHRKLRNTLRAYYDEHIKPYMLEWEEQGDVPEQLRLEHARTGQPFADVPEPYRPADVVGPAGIPVKDLDVFHLMIMTDESSRVEGGVGTAMAGGSVIGVPPVVHYGTEEQKKKWLPGLFTWETSFCLGITEPSGGSDVANIQTTAVKSKDGSHYIVNGYKKWITGMPWATHMTTAVRTGGDGAKGISVLVIPTSSQGFSHRRIPNSGQKAGGASFVELDNVYVPIENLVGKENEGFRIIMKNFNKERFIMSVGCNRKARTCLSHSFEYATKRHTFGKPLISNQIITHKLATLGRYIESHWAWLEQIAYQIQQSPLGWQDPEIAGQIALSKVHGGRILEMANREAQQIFGGAGYQKGGPGAVVEQISRDLRMMVVGGGSEEIIADLAVRQETALAKKRGWKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CA81</accession>
    <name>A0A177CA81_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1206155</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG04485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034850.1">
        <property type="nucleotide sequence ID" value="XM_018182020.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CA81"/>
    <dbReference type="STRING" id="1460663.A0A177CA81"/>
    <dbReference type="GeneID" id="28765506"/>
    <dbReference type="InParanoid" id="A0A177CA81"/>
    <dbReference type="OrthoDB" id="3935706at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008057940" description="F-box domain-containing protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG04485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="601" mass="69645" checksum="8050B22A7613F3B6" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CAN0</accession>
    <name>A0A177CAN0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1177727</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG03780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034145.1">
        <property type="nucleotide sequence ID" value="XM_018180301.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CAN0"/>
    <dbReference type="GeneID" id="28763787"/>
    <dbReference type="InParanoid" id="A0A177CAN0"/>
    <dbReference type="OrthoDB" id="10357026at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008057938" evidence="1">
        <location>
            <begin position="21"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG03780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="110" mass="11659" checksum="683E0CCC44C7C210" modified="2016-09-07" version="1">MKTFTSALLTLGSVSTIVNAVAIDFYANRDCGLFSYSIDTPSEIGCTTLPETVSGLVLKTDIPDGDCLINLFNDESCMGNSVQNFLNGDTQTNVCLPAPQLYVAYSATGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CAZ3</accession>
    <name>A0A177CAZ3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">C4-dicarboxylate transporter/malic acid transport protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CC84DRAFT_1164966</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG04516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034881.1">
        <property type="nucleotide sequence ID" value="XM_018178611.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CAZ3"/>
    <dbReference type="STRING" id="1460663.A0A177CAZ3"/>
    <dbReference type="GeneID" id="28762097"/>
    <dbReference type="InParanoid" id="A0A177CAZ3"/>
    <dbReference type="OrthoDB" id="2901184at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015140">
        <property type="term" value="F:malate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09317">
        <property type="entry name" value="TDT_Mae1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.150">
        <property type="entry name" value="Voltage-dependent anion channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030185">
        <property type="entry name" value="Mae1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004695">
        <property type="entry name" value="SLAC1/Mae1/Ssu1/TehA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038665">
        <property type="entry name" value="Voltage-dep_anion_channel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31162:SF0">
        <property type="entry name" value="MALIC ACID TRANSPORT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31162">
        <property type="entry name" value="MALIC ACID TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03595">
        <property type="entry name" value="SLAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="26"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="100"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="130"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="160"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="202"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="246"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="280"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="312"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAG04516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="374" mass="40675" checksum="D615B44F8704FDBA" modified="2016-09-07" version="1">MSTGAIAVVLANTPNTFPGLMTIGKIFYITNLILFVLFTALITTRFILVPAKLVASLLHPVEGLFFGAYWVTVSLILNGAQSYGVPASGPWLVKALEICYWTYCGVVFVVGVGQYYVFFQSVKLNMHDAVPAWIFPIYPLLVVGTMAGTMIPSQPTDRGWYMWVGAVAFQGLAWVVALLMYSLYTQRLMTSELPSPSTRPGMYVSVGPAGYTAAGLISLATQASTVVPGSQFTQLALPDGDLIKNLGILAGLFIILFAFWFCCISTVAVLAGVRQMSFTLNWWAFIFPNAGLTLATIQIAGALNSDGIRGVASALTIVLVMLWLLVAVLCIKAVYMGELLWPGKDEDKTMKGIRWGRNGAFPEYNAEAQKERED</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CBK3</accession>
    <name>A0A177CBK3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Nuclear pore complex component</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1206321</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG04716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035081.1">
        <property type="nucleotide sequence ID" value="XM_018182026.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CBK3"/>
    <dbReference type="STRING" id="1460663.A0A177CBK3"/>
    <dbReference type="GeneID" id="28765512"/>
    <dbReference type="InParanoid" id="A0A177CBK3"/>
    <dbReference type="OrthoDB" id="429932at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005640">
        <property type="term" value="C:nuclear outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070762">
        <property type="term" value="C:nuclear pore transmembrane ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030474">
        <property type="term" value="P:spindle pole body duplication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012578">
        <property type="entry name" value="Nucl_pore_cmplx"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28003">
        <property type="entry name" value="NUCLEOPORIN POM34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28003:SF1">
        <property type="entry name" value="NUCLEOPORIN POM34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08058">
        <property type="entry name" value="NPCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="11"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="235"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG04716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="288" mass="30912" checksum="9B80C6014462F88A" modified="2016-09-07" version="1">MSQLARTTQGAAPMTPRTPSSAPATPSVLTEEESTPGRWKHPQFDEIARRQYATTFDERNVKMIVTNGSLLVGTFVAPAVISQITLLRTLSKPVLGLLHQLPYNGDEWTLFLFRLIFLANLVRAFMPLARRYFPDDIADIPLTPSQRLAMGLKPGISPRSPASGYASSPNYVTPPRYQKSTPRSSFGAQGSQSPLSGSPRASLGMSTSNSPFSPSTGSPLFQKAVNGGSATKRMSFGGSTPGSSFFGESSSSATPSTPTPSTGKASVGLNNKWLYDKRRDSPRSSLFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CBT8</accession>
    <name>A0A177CBT8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">TauD-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CC84DRAFT_1206043</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TfdA dioxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG04332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034697.1">
        <property type="nucleotide sequence ID" value="XM_018182010.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CBT8"/>
    <dbReference type="FunCoup" id="A0A177CBT8">
        <property type="interactions" value="3"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CBT8"/>
    <dbReference type="GeneID" id="28765496"/>
    <dbReference type="InParanoid" id="A0A177CBT8"/>
    <dbReference type="OrthoDB" id="10257314at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016706">
        <property type="term" value="F:2-oxoglutarate-dependent dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.130.10:FF:000003">
        <property type="entry name" value="Alpha-ketoglutarate-dependent taurine dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051323">
        <property type="entry name" value="AtsK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT SULFONATE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468:SF28">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT TAURINE DIOXYGENASE (AFU_ORTHOLOGUE AFUA_8G02210)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="8">
        <location>
            <begin position="129"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="31"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="35"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAG04332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="414" mass="46165" checksum="E97471D783233A4F" modified="2016-09-07" version="1">MTTEIVSQVEAALPASIATEKPTEHIALRADSPIEQDKPVDRDTTVEQAKSVQPKQLVEETEPGVKEKPKVRRVIDEEGGTTTATYPHYLPVWDHGERYPPWEPFNHTEHGKDADPSFKDLLVEGSKLQHLTPSTGSEVTGVQLSKLSNAGKDQLALLVAQRKVVAFRDQDLADLPIQQALDFGAYFGRHHIHPTSGAPEGYPEIHLVYRNGGNGEFESFLANRNSSVAWHSDVTYEEQPPGTTFLIILDTPEVGGDTAFVNHVEAYNRLSPALKERLHGLTALHSGFEQAEFSRSRGGVVRREPVKHSHPLVRTHPATGEKALFVNGGFTRSIDGLKKEESEYLLKFLVDHIGRGIDYQARVRWAPKTVVVWDNRVTSHSAIVDWVTGERRHLARITPQAERPYETPYVAEAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CCN4</accession>
    <name>A0A177CCN4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Carbamoyl phosphate synthase arginine-specific small chain</fullName>
            <ecNumber evidence="3">6.3.5.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Arginine-specific carbamoyl phosphate synthetase, glutamine chain</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Glutamine-dependent carbamoyl phosphate synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CC84DRAFT_1147207</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-glutamine + H2O = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>hydrogencarbonate + L-glutamine + 2 ATP + H2O = carbamoyl phosphate + L-glutamate + 2 ADP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:18633"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-arginine biosynthesis; carbamoyl phosphate from bicarbonate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Heterodimer composed of 2 chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CarA family.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.5" evidence="3"/>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG04538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034903.1">
        <property type="nucleotide sequence ID" value="XM_018176584.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CCN4"/>
    <dbReference type="FunCoup" id="A0A177CCN4">
        <property type="interactions" value="360"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CCN4"/>
    <dbReference type="GeneID" id="28760070"/>
    <dbReference type="InParanoid" id="A0A177CCN4"/>
    <dbReference type="OrthoDB" id="434at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004088">
        <property type="term" value="F:carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:L-arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01744">
        <property type="entry name" value="GATase1_CPSase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.880:FF:000016">
        <property type="entry name" value="Carbamoyl-phosphate synthase arginine-specific small chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.30.20:FF:000003">
        <property type="entry name" value="Carbamoyl-phosphate synthase arginine-specific small chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.20">
        <property type="entry name" value="Carbamoyl-phosphate synthase small subunit, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01209">
        <property type="entry name" value="CPSase_S_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050472">
        <property type="entry name" value="Anth_synth/Amidotransfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006274">
        <property type="entry name" value="CarbamoylP_synth_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002474">
        <property type="entry name" value="CarbamoylP_synth_ssu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036480">
        <property type="entry name" value="CarbP_synth_ssu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035686">
        <property type="entry name" value="CPSase_GATase1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01368">
        <property type="entry name" value="CPSaseIIsmall"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009475">
        <property type="entry name" value="PRK12838.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43418:SF7">
        <property type="entry name" value="CARBAMOYL-PHOSPHATE SYNTHASE SMALL CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43418">
        <property type="entry name" value="MULTIFUNCTIONAL TRYPTOPHAN BIOSYNTHESIS PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00988">
        <property type="entry name" value="CPSase_sm_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00097">
        <property type="entry name" value="ANTSNTHASEII"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00099">
        <property type="entry name" value="CPSGATASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00096">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01097">
        <property type="entry name" value="CPSase_sm_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52021">
        <property type="entry name" value="Carbamoyl phosphate synthetase, small subunit N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carbamoyl-phosphate synthase small subunit N-terminal" evidence="16">
        <location>
            <begin position="54"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00044334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM01097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="OAG04538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="484" mass="52805" checksum="04BD521CD2C97BE6" modified="2016-09-07" version="1">MMSQFFKPTAVRSAGVLGQVTKNRAQARLMATVQSNTPRQMATPQRIATPISTERATFTIKNGPIFSGKSFGAKVNMSGEAVFTTSLVGYPESMTDPSYRGQILVFTQPLIGNYGVPSLARDEHGLLRHFESPHIQASGIVVQDYAIKHSHWTAVESLAQWCAREGIPAISGVDTREVVTYLREQGSSLARITIGEEYDADEDEAFVDPEAINLVRRVSTKAPFHVSSSLGDMHVALIDCGVKENILRSLVSRGASVTAFPFDYPIHKVAHHFDGVFISNGPGDPTHCTSTVYNLRKLFESSQLPIMGICMGHQLLALAAGAKTIKLKYGNRAHNIPALDLTTGRCHITSQNHGYAIDPTTLPAGWREYFTNLNDQSNEGLIHNTRPIFSAQFHPEAKGGPLDSGYLFDKYIESVKKYKEQQAMFTSKDNKPSPLLVDLLSKERVGVHPAHPDDSEGGHTVGKLQEVVMDTKGTPAPQPIAAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CD67</accession>
    <name>A0A177CD67_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_802179</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG04759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CD67"/>
    <dbReference type="InParanoid" id="A0A177CD67"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG04759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="71" mass="8387" checksum="9A936F0641644D04" modified="2016-09-07" version="1">MAERTGSLVFSVLWSYVKEVVSYCIHIECSFSLLHTVDMPSWEHASSKENPHLHRQEKLERFHAELARFRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CDR9</accession>
    <name>A0A177CDR9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Serine/threonine-protein kinase BUR1</fullName>
            <ecNumber evidence="4">2.7.11.22</ecNumber>
            <ecNumber evidence="3">2.7.11.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Serine/threonine-protein kinase bur1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">CC84DRAFT_1060028</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10216"/>
            <dbReference type="Rhea" id="RHEA-COMP:11321"/>
            <dbReference type="Rhea" id="RHEA-COMP:11322"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43176"/>
            <dbReference type="ChEBI" id="CHEBI:68546"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.23"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="4"/>
    <dbReference type="EC" id="2.7.11.23" evidence="3"/>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG05456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035821.1">
        <property type="nucleotide sequence ID" value="XM_018173576.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CDR9"/>
    <dbReference type="FunCoup" id="A0A177CDR9">
        <property type="interactions" value="195"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CDR9"/>
    <dbReference type="GeneID" id="28757062"/>
    <dbReference type="InParanoid" id="A0A177CDR9"/>
    <dbReference type="OrthoDB" id="28397at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070691">
        <property type="term" value="C:P-TEFb complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070693">
        <property type="term" value="C:P-TEFb-cap methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008353">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030643">
        <property type="term" value="P:intracellular phosphate ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000562">
        <property type="entry name" value="Serine/threonine-protein kinase bur1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000514">
        <property type="entry name" value="Serine/threonine-protein kinase BUR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF233">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 16 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 20" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 16 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 17" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="19">
        <location>
            <begin position="26"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="331"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="20">
        <location>
            <position position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00041018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00073250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="OAG05456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="352" mass="40433" checksum="07AEA5615F7E4C82" modified="2016-09-07" version="1" fragment="single">MANAGAPTPSKGLQRRFKGCSKIGEYELLKKLGEGTFGEVHQARHVRSGRIFAMKKILTHNEKDGFPITALREIKLLKMLSHENVLKLEEMSVERPKAEGRKRAILYMVMPYMDHDLSGLLDNPDVHFSAPQIKCYMLQLFKGLRYLHDNHILHRDMKAANLLINNRGRLQIADFGLARHYDELVPQRGKGNGEARRDYTTLVVTRWYRPPELLLQLRRYTPAIDMWGAGCVFGEMFKRKPILAGQSDLHQAQIIFELVGSPNDRSMPGWNQLPGAEPVRAFPTSTGQLSQKFRELSPQGLDLLSKLLMLDWRKRINAIDAIDHPYFTEEPKPMREEDIPTFADSHELDRRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CEF6</accession>
    <name>A0A177CEF6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Kama family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CC84DRAFT_1148604</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG05292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035657.1">
        <property type="nucleotide sequence ID" value="XM_018176643.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CEF6"/>
    <dbReference type="STRING" id="1460663.A0A177CEF6"/>
    <dbReference type="GeneID" id="28760129"/>
    <dbReference type="InParanoid" id="A0A177CEF6"/>
    <dbReference type="OrthoDB" id="5396721at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003739">
        <property type="entry name" value="Lys_aminomutase/Glu_NH3_mut"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00238">
        <property type="entry name" value="KamA family radical SAM protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30538:SF0">
        <property type="entry name" value="L-LYSINE 2,3-AMINOMUTASE AQ_1632-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30538">
        <property type="entry name" value="LYSINE 2,3-AMINOMUTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01070">
        <property type="entry name" value="PLP-dependent"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="9">
        <location>
            <begin position="261"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="98"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAG05292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="645" mass="71892" checksum="73FE00E8AF55F4E1" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CEQ1</accession>
    <name>A0A177CEQ1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Sodium/hydrogen exchanger</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CC84DRAFT_1163947</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG05392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035757.1">
        <property type="nucleotide sequence ID" value="XM_018178372.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CEQ1"/>
    <dbReference type="GeneID" id="28761858"/>
    <dbReference type="InParanoid" id="A0A177CEQ1"/>
    <dbReference type="OrthoDB" id="1288932at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902600">
        <property type="term" value="P:proton transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006814">
        <property type="term" value="P:sodium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43562">
        <property type="entry name" value="NAPA-TYPE SODIUM/HYDROGEN ANTIPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43562:SF3">
        <property type="entry name" value="SODIUM ION_PROTON EXCHANGER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0050">Antiport</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0915">Sodium</keyword>
    <keyword evidence="9" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="18"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="42"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="72"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="133"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="164"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="196"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="396"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="528"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="domain" description="Cation/H+ exchanger transmembrane" evidence="12">
        <location>
            <begin position="46"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="294"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="332"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="448"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="294"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="333"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="448"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="461"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OAG05392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="578" mass="61826" checksum="D4A9C0BA229DD1D7" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CFI9</accession>
    <name>A0A177CFI9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Protein phosphatase PP2A regulatory subunit A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CC84DRAFT_1196421</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the phosphatase 2A regulatory subunit A family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG06375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036740.1">
        <property type="nucleotide sequence ID" value="XM_018181459.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CFI9"/>
    <dbReference type="FunCoup" id="A0A177CFI9">
        <property type="interactions" value="454"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CFI9"/>
    <dbReference type="GeneID" id="28764945"/>
    <dbReference type="InParanoid" id="A0A177CFI9"/>
    <dbReference type="OrthoDB" id="340346at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005935">
        <property type="term" value="C:cellular bud neck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005934">
        <property type="term" value="C:cellular bud tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000775">
        <property type="term" value="C:chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090443">
        <property type="term" value="C:FAR/SIN/STRIPAK complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110085">
        <property type="term" value="C:mitotic actomyosin contractile ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000159">
        <property type="term" value="C:protein phosphatase type 2A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030952">
        <property type="term" value="P:establishment or maintenance of cytoskeleton polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990813">
        <property type="term" value="P:meiotic centromeric cohesion protection in anaphase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007094">
        <property type="term" value="P:mitotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031030">
        <property type="term" value="P:negative regulation of septation initiation signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000011">
        <property type="entry name" value="Serine/threonine-protein phosphatase 2A regulatory subunit A alpha isoform"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055231">
        <property type="entry name" value="2AA_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054573">
        <property type="entry name" value="PP2A/SF3B1-like_HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051023">
        <property type="entry name" value="PP2A_Regulatory_Subunit_A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10648:SF4">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2 (FORMERLY 2A), REGULATORY SUBUNIT A, BETA ISOFORM-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10648">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A 65 KDA REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22646">
        <property type="entry name" value="PPP2R1A-like_HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22956">
        <property type="entry name" value="VPS15-like_hel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="10"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="HEAT" evidence="3">
        <location>
            <begin position="11"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="3">
        <location>
            <begin position="88"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="3">
        <location>
            <begin position="204"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="3">
        <location>
            <begin position="245"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatase PP2A regulatory subunit A/Splicing factor 3B subunit 1-like HEAT repeat" evidence="4">
        <location>
            <begin position="277"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="3">
        <location>
            <begin position="284"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="3">
        <location>
            <begin position="323"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="3">
        <location>
            <begin position="362"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatase 2A Regulatory Subunit A helical" evidence="5">
        <location>
            <begin position="366"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="3">
        <location>
            <begin position="401"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="3">
        <location>
            <begin position="518"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="3">
        <location>
            <begin position="581"/>
            <end position="613"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF22646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF22956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAG06375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="613" mass="68537" checksum="D1A979CE9E17BD00" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CFW3</accession>
    <name>A0A177CFW3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Myosin-2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CC84DRAFT_1259090</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG05698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036063.1">
        <property type="nucleotide sequence ID" value="XM_018184882.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A177CFW3">
        <property type="interactions" value="582"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CFW3"/>
    <dbReference type="GeneID" id="28768368"/>
    <dbReference type="InParanoid" id="A0A177CFW3"/>
    <dbReference type="OrthoDB" id="6108017at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15480">
        <property type="entry name" value="fMyo2p_CBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23767">
        <property type="entry name" value="IQCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01380">
        <property type="entry name" value="MYSc_Myo5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.820:FF:000001">
        <property type="entry name" value="Myosin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.190">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1590">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002710">
        <property type="entry name" value="Dilute_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046943">
        <property type="entry name" value="Fungal_Myo2/2A_CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036103">
        <property type="entry name" value="MYSc_Myo5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140:SF706">
        <property type="entry name" value="DILUTE CLASS UNCONVENTIONAL MYOSIN, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140">
        <property type="entry name" value="MYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01843">
        <property type="entry name" value="DIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00612">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM01132">
        <property type="entry name" value="DIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00015">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50084">
        <property type="entry name" value="Myosin S1 fragment, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51126">
        <property type="entry name" value="DILUTE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 8" id="KW-0505">Motor protein</keyword>
    <keyword evidence="5 8" id="KW-0518">Myosin</keyword>
    <keyword evidence="2 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myosin motor" evidence="11">
        <location>
            <begin position="74"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="domain" description="Dilute" evidence="10">
        <location>
            <begin position="1223"/>
            <end position="1492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="188"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Actin-binding" evidence="8">
        <location>
            <begin position="653"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1029"/>
            <end position="1050"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1101"/>
            <end position="1129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="189"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="168"/>
            <end position="175"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OAG05698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="1574" mass="179456" checksum="BE4CA363A49ED2B3" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CGD4</accession>
    <name>A0A177CGD4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1205641</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG06002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036367.1">
        <property type="nucleotide sequence ID" value="XM_018181990.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CGD4"/>
    <dbReference type="GeneID" id="28765476"/>
    <dbReference type="InParanoid" id="A0A177CGD4"/>
    <dbReference type="OrthoDB" id="3799525at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="214"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="244"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG06002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="454" mass="51784" checksum="BB8D2D455546116F" modified="2016-09-07" version="1">MSPLDISDSEKGMSVEILTRNLRFPNANVTAIELLTFLPGCLNSPDIVYRFASNGISLDAILSIVNTNRMLEQQWTAEYCYRTVRNAMRHAGHSDWTLKKHLQYFADKLRGWNATSLSVSGFRASLSISDKRKPDADVRFARLADGVKHMPDGDDALDLTRMIQHCVQNPSEEWLYPSNYDMLLAHLGGPTHPVAANMDRPIFERWEHVIPHVPRRNRPSELTTQPKKRGRSGTPQTDGEAPRRSGRRGRPSLKRRELQEDFLGADDSGIEDQVEEFVPPSTPWVKPPVIGRAAMSFQALLYDFSAQPSPKTDDTFDAYAFGYGPRTMAPFRPLHLITIKSLKFEDLSCWAENLRWAAEQHTTFGETGWTECPEHMERIAQFRCEQTWASAELVISIEDHQQEEEEDAAWLEAMIEGTLASMRRRDVDPHISIQGDIDEEYFDAEGRLKFRPRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CGN1</accession>
    <name>A0A177CGN1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_1163047</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG06724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037089.1">
        <property type="nucleotide sequence ID" value="XM_018178161.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CGN1"/>
    <dbReference type="STRING" id="1460663.A0A177CGN1"/>
    <dbReference type="GeneID" id="28761647"/>
    <dbReference type="InParanoid" id="A0A177CGN1"/>
    <dbReference type="OrthoDB" id="6770063at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF60">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="163"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="203"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="227"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="258"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="291"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="320"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="390"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="435"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="476"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="501"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="535"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="569"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="165"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="15"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="44"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="80"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAG06724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="606" mass="66917" checksum="F1467E5B37317E04" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CHB8</accession>
    <name>A0A177CHB8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_761528</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG06342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036707.1">
        <property type="nucleotide sequence ID" value="XM_018187338.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CHB8"/>
    <dbReference type="GeneID" id="28770824"/>
    <dbReference type="InParanoid" id="A0A177CHB8"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG06342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="59" mass="7000" checksum="6CD8D2B5ADC25CDA" modified="2016-09-07" version="1">MLKSWITFVISVYFPYTSLARLLSGSREITHRKKASWASSLLARPRFIREQTYITLYNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CHE3</accession>
    <name>A0A177CHE3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1241957</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG07003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037368.1">
        <property type="nucleotide sequence ID" value="XM_018184074.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CHE3"/>
    <dbReference type="GeneID" id="28767560"/>
    <dbReference type="InParanoid" id="A0A177CHE3"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG07003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="107" mass="11318" checksum="108ADFE4808CD4F8" modified="2016-09-07" version="1">MGTTTEATPNGHPDKTVVASDRSKYVQGNVDDAVWRARACLERIHTQSAYISVLATVLREYRIVPGGGPDAKLVKQETDNPAAGTATLAPVLSVELALKKQTDVGTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CHE6</accession>
    <name>A0A177CHE6_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF1996 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1195345</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG06995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037360.1">
        <property type="nucleotide sequence ID" value="XM_018181404.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CHE6"/>
    <dbReference type="STRING" id="1460663.A0A177CHE6"/>
    <dbReference type="GeneID" id="28764890"/>
    <dbReference type="InParanoid" id="A0A177CHE6"/>
    <dbReference type="OrthoDB" id="74764at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018535">
        <property type="entry name" value="DUF1996"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43662">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43662:SF13">
        <property type="entry name" value="DUF1996 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09362">
        <property type="entry name" value="DUF1996"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008058165" description="DUF1996 domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1996" evidence="2">
        <location>
            <begin position="34"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG06995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="337" mass="37214" checksum="2B822C6DA34A5FF2" modified="2016-09-07" version="1">MVTKRLLVALFALLPPTQALLRFSCSQLVVERLDPLVNPGLSQSPHLHQIIGGNAFNISMDPTVAPPDIATCTTCTFAEDFSNYWTATLYYRAKNGTFKRVPQKGNVNFESSNGGMTVYYIPKNVNGATPGAVTAFKKGFRMIVGNPTYRTEAQAKQFRQLTYTCLQDSMTRTGETLYFPKKPCPAGIMVNVRFPTCWDGVNLDSPDHMSHVAYPSSGTFESNGPCPSTHPVKLPQLFYEVIFDTTKFNDKSLWPDDGSQPFVWSFGDKTGYGNHGDYVFGWKGDALQKAMDTNCNINCPQLKTQSIAQANKCVQSQKVKEDVDGWLSELPGGMPVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CI51</accession>
    <name>A0A177CI51_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Membrane transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CC84DRAFT_1142610</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG06662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037027.1">
        <property type="nucleotide sequence ID" value="XM_018176375.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CI51"/>
    <dbReference type="GeneID" id="28759861"/>
    <dbReference type="InParanoid" id="A0A177CI51"/>
    <dbReference type="OrthoDB" id="3936150at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17316">
        <property type="entry name" value="MFS_SV2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000171">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511:SF4">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511">
        <property type="entry name" value="SYNAPTIC VESICLE GLYCOPROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="135"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="157"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="194"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="243"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="341"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="380"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="411"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="435"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="469"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="497"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="69"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAG06662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="526" mass="57718" checksum="13A6D0C016668789" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CID6</accession>
    <name>A0A177CID6_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial division protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CC84DRAFT_1116347</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in mitochondrial fission. Acts as an adapter protein required to form mitochondrial fission complexes. Formation of these complexes is required to promote constriction and fission of the mitochondrial compartment at a late step in mitochondrial division.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat MDV1/CAF4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG06628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036993.1">
        <property type="nucleotide sequence ID" value="XM_018175458.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CID6"/>
    <dbReference type="STRING" id="1460663.A0A177CID6"/>
    <dbReference type="GeneID" id="28758944"/>
    <dbReference type="InParanoid" id="A0A177CID6"/>
    <dbReference type="OrthoDB" id="674604at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990234">
        <property type="term" value="C:transferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847:SF637">
        <property type="entry name" value="WD REPEAT DOMAIN 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 6" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="8">
        <location>
            <begin position="75"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="632"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="673"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="715"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="757"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="839"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="881"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="923"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="1020"/>
            <end position="1060"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="1061"/>
            <end position="1102"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="1103"/>
            <end position="1134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00039789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00043913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAG06628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="1241" mass="137762" checksum="750DEE58B92C0622" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CIE8</accession>
    <name>A0A177CIE8_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">protein-ribulosamine 3-kinase</fullName>
            <ecNumber evidence="1">2.7.1.172</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_1089911</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>N(6)-D-ribulosyl-L-lysyl-[protein] + ATP = N(6)-(3-O-phospho-D-ribulosyl)-L-lysyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48432"/>
            <dbReference type="Rhea" id="RHEA-COMP:12103"/>
            <dbReference type="Rhea" id="RHEA-COMP:12104"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:90418"/>
            <dbReference type="ChEBI" id="CHEBI:90420"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.172"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="2">
            <dbReference type="Rhea" id="RHEA:48433"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the fructosamine kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.172" evidence="1"/>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG06638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037003.1">
        <property type="nucleotide sequence ID" value="XM_018174329.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CIE8"/>
    <dbReference type="STRING" id="1460663.A0A177CIE8"/>
    <dbReference type="GeneID" id="28757815"/>
    <dbReference type="InParanoid" id="A0A177CIE8"/>
    <dbReference type="OrthoDB" id="5772781at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102193">
        <property type="term" value="F:protein-ribulosamine 3-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1200.10:FF:000018">
        <property type="entry name" value="Fructosamine-3-kinase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016477">
        <property type="entry name" value="Fructo-/Ketosamine-3-kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12149">
        <property type="entry name" value="FRUCTOSAMINE 3 KINASE-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12149:SF8">
        <property type="entry name" value="PROTEIN-RIBULOSAMINE 3-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03881">
        <property type="entry name" value="Fructosamin_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006221">
        <property type="entry name" value="Ketosamine-3-kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00048655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR006221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAG06638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="328" mass="35588" checksum="91E2C29A36D37841" modified="2016-09-07" version="1">MKLDPAVVELLRLDAEQTTVSSAGGGGCSSASTFKITSKLSDGTEKRFFMKTGKGGNAEVMFAGEHASLRAIHDTVPSLCPQSYGHGRFSSQSSTSFLVTDFLNLTSRSAPTSSAPSLAAKLAKLHTTPAPVPDGYDKPMFGFPVTTCCGDTPQDNSFKDSWADFFANNRLRFILGRVEKSNSVDKELHTLVEMIASRVVPRLLGDEHLNNGQGVKPVVVHGDLWSGNAGVGTIGSDTGAQDIVYDSSACYAHNEFELGIMKMFGGFGGSFLKEYHDLCPKTEPVAEYEDRVKLYELYHHLNHYAMFGGSYRSGAVNIMRSLVRKYGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CIF8</accession>
    <name>A0A177CIF8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_610313</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG06648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037013.1">
        <property type="nucleotide sequence ID" value="XM_018186879.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CIF8"/>
    <dbReference type="GeneID" id="28770365"/>
    <dbReference type="InParanoid" id="A0A177CIF8"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG06648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="71" mass="7628" checksum="D904144883687A67" modified="2016-09-07" version="1">MPAPHGGASRPLCITISSLCGQSSQARLESALHIQAHAVAVCLAACGRHETIESLSQYRCSSRDRCLKRHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CIJ7</accession>
    <name>A0A177CIJ7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CC84DRAFT_1143810</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Mycotoxin biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG07335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037700.1">
        <property type="nucleotide sequence ID" value="XM_018176434.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CIJ7"/>
    <dbReference type="STRING" id="1460663.A0A177CIJ7"/>
    <dbReference type="GeneID" id="28759920"/>
    <dbReference type="InParanoid" id="A0A177CIJ7"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902181">
        <property type="term" value="P:verruculogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11061">
        <property type="entry name" value="CYP67-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000063">
        <property type="entry name" value="Cytochrome P450 monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF237">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE ATNE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13 14" id="KW-0349">Heme</keyword>
    <keyword evidence="10 13 14" id="KW-0408">Iron</keyword>
    <keyword evidence="12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 14" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="13">
        <location>
            <position position="454"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OAG07335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="531" mass="59346" checksum="B3034F9B63746E46" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CJN3</accession>
    <name>A0A177CJN3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acid protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_1062954</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG07040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037405.1">
        <property type="nucleotide sequence ID" value="XM_018173601.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CJN3"/>
    <dbReference type="STRING" id="1460663.A0A177CJN3"/>
    <dbReference type="GeneID" id="28757087"/>
    <dbReference type="InParanoid" id="A0A177CJN3"/>
    <dbReference type="OrthoDB" id="4074350at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05471">
        <property type="entry name" value="pepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034164">
        <property type="entry name" value="Pepsin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF51">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="415"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="3">
        <location>
            <begin position="20"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAG07040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="440" mass="47645" checksum="FF07F496D77D69DD" modified="2016-09-07" version="1" fragment="single">PEPYEVPPSQEWDGNDGSWSTFKLTIGAPPQEFRVLASTQSGQTIIVVPDGCIAGHDPSDCAESRGAQIFNSAQSPGFLTNTSSTWDLIGQYNIDLEERLGLNTTPGIFGYDMVGLGASGSNSVISVNSSLVGGVANMVYYMGHIPLGVTKSKFGSQSQAVDPLIQQLRKSTQIPSISFSYTAGAKYRLKSVTGQLIFGGYDPTRFEPNTNEFSFSFSADPSRLLTVGVDSVIATNSLKGTYSLSTSTHFSLIDSTTSMLWLPRDVCDAFEESFGLTYDPTTDLYLINTTMRDQLRARNPSVTFKLIDSLEGAATNFTSILLPYSAFDLQASYPYYENATNYFPIRRASNESQYTLGRTLLQEAYLIVDYERANFTLAQAAFPSPLPRASIVAIPPPDTQATASPSPSLSAGAKAGIAIGSLTLVSFLAALAFWFFRGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CJY3</accession>
    <name>A0A177CJY3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">UDP-Glycosyltransferase/glycogen phosphorylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CC84DRAFT_1144640</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG07803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038168.1">
        <property type="nucleotide sequence ID" value="XM_018176464.1"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CJY3"/>
    <dbReference type="GeneID" id="28759950"/>
    <dbReference type="InParanoid" id="A0A177CJY3"/>
    <dbReference type="OrthoDB" id="5835829at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016906">
        <property type="term" value="F:sterol 3-beta-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000100">
        <property type="entry name" value="Glycosyltransferase family 1 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000009">
        <property type="entry name" value="Sterol 3-beta-glucosyltransferase UGT80A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010610">
        <property type="entry name" value="EryCIII-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050426">
        <property type="entry name" value="Glycosyltransferase_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004276">
        <property type="entry name" value="GlycoTrans_28_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48050">
        <property type="entry name" value="STEROL 3-BETA-GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48050:SF13">
        <property type="entry name" value="STEROL 3-BETA-GLUCOSYLTRANSFERASE UGT80A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06722">
        <property type="entry name" value="EryCIII-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03033">
        <property type="entry name" value="Glyco_transf_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00726">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50330">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyltransferase family 28 N-terminal" evidence="3">
        <location>
            <begin position="192"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="Erythromycin biosynthesis protein CIII-like C-terminal" evidence="4">
        <location>
            <begin position="523"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="737"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1077"/>
            <end position="1137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1261"/>
            <end position="1283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1295"/>
            <end position="1396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="30"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="770"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="826"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="856"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1078"/>
            <end position="1092"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1128"/>
            <end position="1137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1272"/>
            <end position="1283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1295"/>
            <end position="1308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1329"/>
            <end position="1354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1371"/>
            <end position="1384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="1386"/>
            <end position="1396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAG07803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="1396" mass="150789" checksum="ADE077A123723E75" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CKJ8</accession>
    <name>A0A177CKJ8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_1090139</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG07398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037763.1">
        <property type="nucleotide sequence ID" value="XM_018174341.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CKJ8"/>
    <dbReference type="STRING" id="1460663.A0A177CKJ8"/>
    <dbReference type="GeneID" id="28757827"/>
    <dbReference type="InParanoid" id="A0A177CKJ8"/>
    <dbReference type="OrthoDB" id="429813at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051414">
        <property type="entry name" value="Adenylate-forming_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43439:SF2">
        <property type="entry name" value="ENZYME, PUTATIVE (JCVI)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43439">
        <property type="entry name" value="PHENYLACETATE-COENZYME A LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioester reductase (TE)" evidence="3">
        <location>
            <begin position="45"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAG07398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="370" mass="41110" checksum="802C2386A5B44926" modified="2016-09-07" version="1" fragment="single">RTTPKPHALHSRTSAMEGLVQKYSQGLEKLSTPVKEDIGPRNVALVGSTGYLGPHLLASILKLPSIASVYWLNSGSTVEKTLKSTGYQEIECSRSIQFFVANLASAKLGLSDGDFSEVSVKVDTIMHNSWHPSFSLSLSFFEKPFLLGLRKIVDWARRRPTPPRFVFISSIAGVGNWSKVVPSQPHIPESRIEDPDVAMHMGYGESKRAGQHMLQIAHDVCGIPISVVRIGQICGPSTQSGGKWPTQGWLLAIDTTSKALGALPTRVAPVNWIPADALATQITCVVTHASTSVEYHVFNVVYPDVASWELFLNVLRNRFSVDAGRISLPEWLNRLEERANLNLEEQKKYVALRFSDFLRSMGDWQRRYDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CKN0</accession>
    <name>A0A177CKN0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_655900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG07399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037764.1">
        <property type="nucleotide sequence ID" value="XM_018187032.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CKN0"/>
    <dbReference type="GeneID" id="28770518"/>
    <dbReference type="InParanoid" id="A0A177CKN0"/>
    <dbReference type="OrthoDB" id="3746964at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="203"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG07399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="237" mass="26176" checksum="C05E7AB1222EB251" modified="2016-09-07" version="1">MVNFQKLLTLSLIPTVIFTILSFISIVLTAHYWILTDYFVGRWLKRKSQFPEKNKFQWDDVIVDYTETSTNAIIAAGCLCLAAGVNCIIAYFKLKPSTMDLDYHSPLRRFWVGSAIGMAVVGLCSALAALITTFTDKGDDEFGCTTTTGKTKDGGVPFTNMMCSREIATCKFMGPVYDKAGKIPNVERWAVTIACNEATVVKWLQLVLIFNAVLVIAMFAAQAGVRRKTRSPASKGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CL65</accession>
    <name>A0A177CL65_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Isochorismatase hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_1162230</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the isochorismatase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038618.1">
        <property type="nucleotide sequence ID" value="XM_018177944.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CL65"/>
    <dbReference type="STRING" id="1460663.A0A177CL65"/>
    <dbReference type="GeneID" id="28761430"/>
    <dbReference type="InParanoid" id="A0A177CL65"/>
    <dbReference type="OrthoDB" id="167809at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00431">
        <property type="entry name" value="cysteine_hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="entry name" value="Isochorismatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050272">
        <property type="entry name" value="Isochorismatase-like_hydrls"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43540:SF9">
        <property type="entry name" value="FAMILY HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G08700)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43540">
        <property type="entry name" value="PEROXYUREIDOACRYLATE/UREIDOACRYLATE AMIDOHYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="Isochorismatase-like hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase-like" evidence="3">
        <location>
            <begin position="131"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAG08253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="343" mass="38162" checksum="76DD60FCA4758991" modified="2016-09-07" version="1">MLTAEQSSQWNAIRCRGAGLVRGHPFLTSKHQGRLLCYISVSILLLSISTQHHISMASNSLLLTKTEDYDNDVTVGTIKCTAPVAFGGEEQWFYLPATKKFDLTRGAAQKMVFECDADERHTGFMIDPGTSVLIVVDMQNYFINPIYRDHAAGLAAIEPTLKVIERCRKEGIQIAWLNWGINDQSLQSMAPAIQRGFSTSLGWHIGLGAQLPAKQGRCLFKRTWNAELYDPFRAVAQPGDLFFDKTRMSGLWSTEEPLHEYLRAVGKQTLLFAGVNTDQCVFGTVSDAYSYGWDCIMLRDCTGTMTGRGAQELTEYQVSTNMGFVTTSSAFCEALICEHFEGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CLK5</accession>
    <name>A0A177CLK5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Regulator of G protein signaling superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_714095</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG07748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038113.1">
        <property type="nucleotide sequence ID" value="XM_018187133.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CLK5"/>
    <dbReference type="FunCoup" id="A0A177CLK5">
        <property type="interactions" value="14"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CLK5"/>
    <dbReference type="GeneID" id="28770619"/>
    <dbReference type="InParanoid" id="A0A177CLK5"/>
    <dbReference type="OrthoDB" id="5584247at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07440">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052246">
        <property type="entry name" value="Cell_Polariz_PKAAnc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016137">
        <property type="entry name" value="RGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13155:SF1">
        <property type="entry name" value="A-KINASE ANCHOR PROTEIN 10, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13155">
        <property type="entry name" value="A-KINASE ANCHOR PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00615">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00315">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50132">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="250"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="282"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="336"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="RGS" evidence="3">
        <location>
            <begin position="169"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAG07748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="361" mass="41237" checksum="B639B0EC88A368DC" modified="2016-09-07" version="1">MSDSPLPAELNRNRFPNLFEVLSRKTVAPLDLFSFYIYMRDQQRSVDYLDFWLDVSQHLQLCRLYVRRLHRSVIEDTPDMEKNSKRSSYILDNAGEGPSGEKGNVSDQRLSAFLRSDHGSRQHSPQNSQGSNQSREVPGRPSFMTLHTDSPQDSSPGQNSSGDNQPRREDLRASAEKILYTYLLPGSEREIIIPQSILHDVQEAIEGPDQRSDPELFDAAKDYVFQAMERDAFPGFLQSKGLGNLVPQSMMIRLIIGLISFFGAVWTAFILIFLNKSRATRCWVILPFTVALYFIFTHQYMLDPILALIGYSEYTLMDFNRIREPFVRKTLNARSATMLGLFVLVDTAVCCLFIFVPGKRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CM42</accession>
    <name>A0A177CM42_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stress-response A/B barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1214557</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038377.1">
        <property type="nucleotide sequence ID" value="XM_018182641.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CM42"/>
    <dbReference type="GeneID" id="28766127"/>
    <dbReference type="InParanoid" id="A0A177CM42"/>
    <dbReference type="OrthoDB" id="1601230at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013097">
        <property type="entry name" value="Dabb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07876">
        <property type="entry name" value="Dabb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51502">
        <property type="entry name" value="S_R_A_B_BARREL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Stress-response A/B barrel" evidence="1">
        <location>
            <begin position="15"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG08012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="125" mass="14042" checksum="9DA0066E9DDBF0A9" modified="2016-09-07" version="1">MAMGEDAEAAKCVTVTRIACFKFRDWVAAGDIGARTGAFLALYDEYAHLLAEKPRGGRPLDTPLNLTGVQRDKGWDTGFVVRFKSEAARLEFDKAEGHDKLKNETDPLLERVFVYDFVDQENLGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CMF1</accession>
    <name>A0A177CMF1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acyl-coenzyme A thioesteras-like protein 13</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_1162116</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioesterase PaaI family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038487.1">
        <property type="nucleotide sequence ID" value="XM_018177910.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CMF1"/>
    <dbReference type="STRING" id="1460663.A0A177CMF1"/>
    <dbReference type="GeneID" id="28761396"/>
    <dbReference type="InParanoid" id="A0A177CMF1"/>
    <dbReference type="OrthoDB" id="46529at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:fatty acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03443">
        <property type="entry name" value="PaaI_thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.129.10:FF:000033">
        <property type="entry name" value="acyl-coenzyme A thioesterase 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039298">
        <property type="entry name" value="ACOT13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003736">
        <property type="entry name" value="PAAI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00369">
        <property type="entry name" value="unchar_dom_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21660:SF1">
        <property type="entry name" value="ACYL-COENZYME A THIOESTERASE 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21660">
        <property type="entry name" value="THIOESTERASE SUPERFAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioesterase" evidence="3">
        <location>
            <begin position="53"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAG08122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="160" mass="17419" checksum="B84DBA14C96B19ED" modified="2016-09-07" version="1">MPALKFVRSVWESFRASSGLEPRLLDGLKVTSAVPGRVKFELPIEKHHTNRLNILHGGTIASMVDLGGSLAVASRGLFATGVSTDLNVTYLSSGGKIGDLIRAEVSCDKFGKTMAFTSIQFKNEKDEVFARGSHTKFIALAWKDPNNITGELSPRVEKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CMK2</accession>
    <name>A0A177CMK2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1239732</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038891.1">
        <property type="nucleotide sequence ID" value="XM_018183987.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CMK2"/>
    <dbReference type="GeneID" id="28767473"/>
    <dbReference type="InParanoid" id="A0A177CMK2"/>
    <dbReference type="OrthoDB" id="3790858at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="48"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="122"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="232"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="333"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="64"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="149"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG08526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="382" mass="43015" checksum="C1E49D528B5A5BC4" modified="2016-09-07" version="1">MCMMVAYYFLAADRIPEIATRTSSFIHHFAKLCGNIYVHTADEIDSREASAPAPIDGPRVGQAIPSTRLSRSLDQQDRASVLPLLETQQQDSHRKQGADDDVFQTRKDTSDAQIIASTYHVGDKGDRSSVPPVNGDSPRISSPMVWDGSNVSPTTQLPRNSTDRLMDLASPKGTPEIELQNREKVIQPVLAEKKALNIDDLAAFVARFKELEAETTQLQEHRVANADLKGLVSQAKDDAKRACTQVQELQERSLNQKSEIEELRKELARTEKDSTDMTLKLTTDLDQERQKLQLVQRAHVQTRSKLSTVQAEKEQLMQRVAWVERSRPSAQKLAVMEASLQAMEADKKGMQDRIRILEGQVQAEKNKFSEYKRKIRNLSLDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CMK7</accession>
    <name>A0A177CMK7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 14 17">Homoserine dehydrogenase</fullName>
            <shortName evidence="14">HDH</shortName>
            <ecNumber evidence="5 14 17">1.1.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">CC84DRAFT_1162099</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes the conversion of L-aspartate-beta-semialdehyde (L-Asa) to L-homoserine (L-Hse), the third step in the biosynthesis of amino acids that derive from aspartate (the aspartate family of amino acids), including methioinine and threonine, the latter of which is a precursor to isoleucine; production of homoserine leads to a branch-point in the pathway as it can either be O-phosphorylated for processing to threonine, or O-acylated for processing to methionine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-homoserine + NADP(+) = L-aspartate 4-semialdehyde + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15761"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57476"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:537519"/>
            <dbReference type="EC" id="1.1.1.3"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="12">
            <dbReference type="Rhea" id="RHEA:15763"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:25213"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 17">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 3/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 17">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 3/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 14 18">Belongs to the homoserine dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.3" evidence="5 14 17"/>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038465.1">
        <property type="nucleotide sequence ID" value="XM_018177907.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CMK7"/>
    <dbReference type="FunCoup" id="A0A177CMK7">
        <property type="interactions" value="340"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CMK7"/>
    <dbReference type="GeneID" id="28761393"/>
    <dbReference type="InParanoid" id="A0A177CMK7"/>
    <dbReference type="OrthoDB" id="67851at2759"/>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00063"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00465"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004412">
        <property type="term" value="F:homoserine dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009090">
        <property type="term" value="P:homoserine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.10:FF:000006">
        <property type="entry name" value="Bifunctional aspartokinase/homoserine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005106">
        <property type="entry name" value="Asp/hSer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011147">
        <property type="entry name" value="Bifunc_Aspkin/hSer_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001342">
        <property type="entry name" value="HDH_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019811">
        <property type="entry name" value="HDH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022697">
        <property type="entry name" value="HDH_short"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43070:SF5">
        <property type="entry name" value="HOMOSERINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00742">
        <property type="entry name" value="Homoserine_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03447">
        <property type="entry name" value="NAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036497">
        <property type="entry name" value="HDH_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01042">
        <property type="entry name" value="HOMOSER_DHGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 14 17" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="11 14 17" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="9 14 16" id="KW-0521">NADP</keyword>
    <keyword evidence="10 14 17" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 14 17" id="KW-0791">Threonine biosynthesis</keyword>
    <feature type="domain" description="Aspartate/homoserine dehydrogenase NAD-binding" evidence="20">
        <location>
            <begin position="13"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="Homoserine dehydrogenase catalytic" evidence="19">
        <location>
            <begin position="168"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="15">
        <location>
            <position position="240"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="13"/>
            <end position="18"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>NADPH</name>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>NADPH</name>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="225"/>
        </location>
        <ligand>
            <name>L-homoserine</name>
            <dbReference type="ChEBI" id="CHEBI:57476"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00059589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRNR" id="PIRNR036497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR036497-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR036497-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU004171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF03447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="OAG08100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="378" mass="40301" checksum="6EBB3E47A1FEE3A0" modified="2016-09-07" version="1">MPLPRQVFVAVIGAGGVGKCFLAQLSSLAQSLSQSPAAPTYLSLIYLSTSKKALLHADYKSQQLSSWESELQASSTAPLPPPQLADYLVKAPGKVILVDNTSNQEVADSYPLFLKKGISIVTPNKKAFSGSYKLWEDIFNVASNGTGANGLGAGGYVFHESSVGAGLPVIVTLKDLIRTGDEIRKIEGVFSGTMSFLFNSFQPTNGGGGKFSAEVKKAKDLGYTEPDPRDDLNGLDVARKLTILARIAGLKVESPTSFPVQSLIPKELESASSGDEFLSRLPEFDGQMDQLKADAEKEDKVVRFVGSIDVQNGDVKVGLEKFDKSHPIAALKGSDNIIAFYTKRYGDNPLIIQGAGAGGDVTAMGVTGDLLRVLRLIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CPN1</accession>
    <name>A0A177CPN1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">peptidyl-tRNA hydrolase</fullName>
            <ecNumber evidence="1">3.1.1.29</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CC84DRAFT_432976</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the PTH family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.29" evidence="1"/>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG09266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039631.1">
        <property type="nucleotide sequence ID" value="XM_018186233.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CPN1"/>
    <dbReference type="FunCoup" id="A0A177CPN1">
        <property type="interactions" value="108"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CPN1"/>
    <dbReference type="GeneID" id="28769719"/>
    <dbReference type="InParanoid" id="A0A177CPN1"/>
    <dbReference type="OrthoDB" id="1711136at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004045">
        <property type="term" value="F:peptidyl-tRNA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1470">
        <property type="entry name" value="Peptidyl-tRNA hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001328">
        <property type="entry name" value="Pept_tRNA_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018171">
        <property type="entry name" value="Pept_tRNA_hydro_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036416">
        <property type="entry name" value="Pept_tRNA_hydro_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00447">
        <property type="entry name" value="pth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17224">
        <property type="entry name" value="PEPTIDYL-TRNA HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17224:SF1">
        <property type="entry name" value="PEPTIDYL-TRNA HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01195">
        <property type="entry name" value="Pept_tRNA_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53178">
        <property type="entry name" value="Peptidyl-tRNA hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01196">
        <property type="entry name" value="PEPT_TRNA_HYDROL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0820">tRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="75"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAG09266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="328" mass="35101" checksum="4BA3755580A90311" modified="2016-09-07" version="1">MCGNAATRAHVDTPAPAAIPASAPTDRRPKTIDARPPTSCNNHDDDSTTTFSQPEIAPIRTPPSSRKEKRKQRKNATLPTPPSSDTEQPTKRTPPNNPQRAPSLSPSLTMAKSLTQKTYPLLICSLGNPGPTYAHTLHSAGHTLTSHIAAVKSYQPFTAGLSGRVARPDNTTYSFGPLQGFRKTNSKEVGPGEDDWTLWQSTSLMNVSGKPLARAFAAFSSELARHGRGPGRLVVIHDELEAPLGKVSVRDGGSSARGHNGVKSVQGAMPGGTKWWRIGVGIGRPESREPDAVAGYVLRKMHAGEMRAMEKACAGVVKVLREISEGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CPT5</accession>
    <name>A0A177CPT5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1162763</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039313.1">
        <property type="nucleotide sequence ID" value="XM_018178088.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CPT5"/>
    <dbReference type="STRING" id="1460663.A0A177CPT5"/>
    <dbReference type="GeneID" id="28761574"/>
    <dbReference type="InParanoid" id="A0A177CPT5"/>
    <dbReference type="OrthoDB" id="5415512at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="238"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="363"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="403"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="510"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG08948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="539" mass="62098" checksum="295C3CB9B17BDA96" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CPX3</accession>
    <name>A0A177CPX3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">G-patch domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1162649</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039172.1">
        <property type="nucleotide sequence ID" value="XM_018178051.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CPX3"/>
    <dbReference type="FunCoup" id="A0A177CPX3">
        <property type="interactions" value="236"/>
    </dbReference>
    <dbReference type="GeneID" id="28761537"/>
    <dbReference type="InParanoid" id="A0A177CPX3"/>
    <dbReference type="OrthoDB" id="786951at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025239">
        <property type="entry name" value="DUF4187"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039249">
        <property type="entry name" value="GPATCH11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21032">
        <property type="entry name" value="G PATCH DOMAIN-CONTAINING PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21032:SF0">
        <property type="entry name" value="G PATCH DOMAIN-CONTAINING PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13821">
        <property type="entry name" value="DUF4187"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01173">
        <property type="entry name" value="DUF4187"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00443">
        <property type="entry name" value="G_patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G-patch" evidence="2">
        <location>
            <begin position="68"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG08807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="308" mass="35450" checksum="8A02531FA472BE74" modified="2016-09-07" version="1">MADSDSEEDYMKMIFDDTPKQPAHETSLQRAARKRKEGEARARQKTKAEREADAEAAREAALATALPENNKGFKMMAKFGFKQGDSLGKAEDARKVPIQVNVKEDRSGIGLESEKKRKLREAWNEAARAAKRSKEEEGDYLEDRKQQQREKKMQWDLDNAQRTAERLSDKEAEEADGASLEGKPLKDINVLWRIRARRRVEKEHDRRQRRELEHCLASRLPTLAQEDEDNDSKVAQGHDVTPFYTSLENDLEDEDPELAEFEALPVGERLIKVLAFLREKYKYCLYCGYQYPDAAMEGCPGITEEDHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CPZ3</accession>
    <name>A0A177CPZ3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Multifunctional tryptophan biosynthesis protein</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="16">Anthranilate synthase component 2</fullName>
                <shortName evidence="16">AS</shortName>
                <ecNumber evidence="16">4.1.3.27</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="16">Anthranilate synthase, glutamine amidotransferase component</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="16">Indole-3-glycerol phosphate synthase</fullName>
                <shortName evidence="16">IGPS</shortName>
                <ecNumber evidence="16">4.1.1.48</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="16">N-(5'-phosphoribosyl)anthranilate isomerase</fullName>
                <shortName evidence="16">PRAI</shortName>
                <ecNumber evidence="16">5.3.1.24</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="21" type="ORF">CC84DRAFT_1183754</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 16">Trifunctional enzyme bearing the Gln amidotransferase (GATase) domain of anthranilate synthase, indole-glycerolphosphate synthase, and phosphoribosylanthranilate isomerase activities.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 16">
            <text>1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate + H(+) = (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:23476"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:58613"/>
            <dbReference type="ChEBI" id="CHEBI:58866"/>
            <dbReference type="EC" id="4.1.1.48"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 16">
            <text>N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:21540"/>
            <dbReference type="ChEBI" id="CHEBI:18277"/>
            <dbReference type="ChEBI" id="CHEBI:58613"/>
            <dbReference type="EC" id="5.3.1.24"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15 16">
            <text>chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21732"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="4.1.3.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6 16">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 1/5.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 16">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 3/5.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5 16">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 4/5.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.27" evidence="16"/>
    <dbReference type="EC" id="4.1.1.48" evidence="16"/>
    <dbReference type="EC" id="5.3.1.24" evidence="16"/>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG09376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039741.1">
        <property type="nucleotide sequence ID" value="XM_018180705.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CPZ3"/>
    <dbReference type="FunCoup" id="A0A177CPZ3">
        <property type="interactions" value="393"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CPZ3"/>
    <dbReference type="GeneID" id="28764191"/>
    <dbReference type="InParanoid" id="A0A177CPZ3"/>
    <dbReference type="OrthoDB" id="524799at2759"/>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00040"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004049">
        <property type="term" value="F:anthranilate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004425">
        <property type="term" value="F:indole-3-glycerol-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004640">
        <property type="term" value="F:phosphoribosylanthranilate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:L-tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01743">
        <property type="entry name" value="GATase1_Anthranilate_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00331">
        <property type="entry name" value="IGPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00405">
        <property type="entry name" value="PRAI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000136">
        <property type="entry name" value="Multifunctional tryptophan biosynthesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.880:FF:000031">
        <property type="entry name" value="Multifunctional tryptophan biosynthesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00134_B">
        <property type="entry name" value="IGPS_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00135">
        <property type="entry name" value="PRAI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050472">
        <property type="entry name" value="Anth_synth/Amidotransfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016302">
        <property type="entry name" value="Anthranilate_synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013798">
        <property type="entry name" value="Indole-3-glycerol_P_synth_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001468">
        <property type="entry name" value="Indole-3-GlycerolPSynthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001240">
        <property type="entry name" value="PRAI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006221">
        <property type="entry name" value="TrpG/PapA_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001377">
        <property type="entry name" value="PRK00278.2-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00566">
        <property type="entry name" value="trpG_papA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43418:SF4">
        <property type="entry name" value="MULTIFUNCTIONAL TRYPTOPHAN BIOSYNTHESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43418">
        <property type="entry name" value="MULTIFUNCTIONAL TRYPTOPHAN BIOSYNTHESIS PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00218">
        <property type="entry name" value="IGPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00697">
        <property type="entry name" value="PRAI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001382">
        <property type="entry name" value="TrpG-trpC-trpF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00097">
        <property type="entry name" value="ANTSNTHASEII"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00096">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00614">
        <property type="entry name" value="IGPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 16" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="11 16" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="8 16" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="10" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="12 16" id="KW-0413">Isomerase</keyword>
    <keyword evidence="13 16" id="KW-0456">Lyase</keyword>
    <keyword evidence="14" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 16" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="Glutamine amidotransferase" evidence="18">
        <location>
            <begin position="29"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="Indole-3-glycerol phosphate synthase" evidence="19">
        <location>
            <begin position="259"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="domain" description="N-(5'phosphoribosyl) anthranilate isomerase (PRAI)" evidence="20">
        <location>
            <begin position="582"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00004873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRNR" id="PIRNR001382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF00697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="OAG09376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="770" mass="82879" checksum="E9A02F651200097E" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CQP0</accession>
    <name>A0A177CQP0_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Cytosine deaminase</fullName>
            <ecNumber evidence="14">3.5.4.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Cytosine aminohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CC84DRAFT_1185730</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the hydrolytic deamination of cytosine to uracil or 5-methylcytosine to thymine. Is involved in the pyrimidine salvage pathway, which allows the cell to utilize cytosine for pyrimidine nucleotide synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>cytosine + H2O + H(+) = uracil + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:20605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16040"/>
            <dbReference type="ChEBI" id="CHEBI:17568"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.4.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="13">Pyrimidine metabolism; UMP biosynthesis via salvage pathway; uracil from cytosine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cytidine and deoxycytidylate deaminase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.1" evidence="14"/>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG09077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039442.1">
        <property type="nucleotide sequence ID" value="XM_018180817.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CQP0"/>
    <dbReference type="FunCoup" id="A0A177CQP0">
        <property type="interactions" value="146"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CQP0"/>
    <dbReference type="GeneID" id="28764303"/>
    <dbReference type="InParanoid" id="A0A177CQP0"/>
    <dbReference type="OrthoDB" id="408702at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004131">
        <property type="term" value="F:cytosine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008835">
        <property type="term" value="F:diaminohydroxyphosphoribosylaminopyrimidine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046087">
        <property type="term" value="P:cytidine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019858">
        <property type="term" value="P:cytosine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008655">
        <property type="term" value="P:pyrimidine-containing compound salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01285">
        <property type="entry name" value="nucleoside_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000016">
        <property type="entry name" value="Cytosine deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11079:SF190">
        <property type="entry name" value="CYTOSINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11079">
        <property type="entry name" value="CYTOSINE DEAMINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="17">
        <location>
            <begin position="2"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00050113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00056232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00060700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00066550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00074321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00084039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="OAG09077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="152" mass="16508" checksum="D49CE2858ACFAF7F" modified="2016-09-07" version="1">MSESDVGFKAAFDEAHKGSEEGGVPIGAALVSAEGKLLGSGHNMRMQKGSATLHAEISALENAGRLPASVYHGATMYTTLSPCDMCTGACVMYKVKRVVIGENKNFLGGEEYLKSKGIEVVVLHNKELQTLMKKFIKEHPEEWYEDIGEETN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CQV4</accession>
    <name>A0A177CQV4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF775-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_1183949</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the OPI10 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG09686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040051.1">
        <property type="nucleotide sequence ID" value="XM_018180719.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CQV4"/>
    <dbReference type="FunCoup" id="A0A177CQV4">
        <property type="interactions" value="343"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CQV4"/>
    <dbReference type="GeneID" id="28764205"/>
    <dbReference type="InParanoid" id="A0A177CQV4"/>
    <dbReference type="OrthoDB" id="10248398at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061608">
        <property type="term" value="F:nuclear import signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006020">
        <property type="term" value="P:inositol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048364">
        <property type="entry name" value="Hikeshi-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008493">
        <property type="entry name" value="Hikeshi-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031318">
        <property type="entry name" value="OPI10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12925">
        <property type="entry name" value="HIKESHI FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12925:SF0">
        <property type="entry name" value="PROTEIN HIKESHI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21057">
        <property type="entry name" value="Hikeshi-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05603">
        <property type="entry name" value="Hikeshi-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hikeshi-like N-terminal" evidence="2">
        <location>
            <begin position="5"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="Hikeshi-like C-terminal" evidence="3">
        <location>
            <begin position="155"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF21057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAG09686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="209" mass="22073" checksum="228A460EE1F7A192" modified="2016-09-07" version="1">MFGVIVSGRPVLTDAQAVSETQFAFQIPSVPTFSHIVVFLLPGTTLPDGTAAAVYAQLPYTSEFKLLGAIANEKPSAIFKVNNRAGGPAGGGVGNEDAMVDASVPLNGAAVPPLALGISVEPAMQVAANLEQQKAQGSTNPNAGTEMVLRQNPVTTKVLAQRIIKNCYDFLTSWGSGDTVPLKAFQAWWTKFENKIEHDPSFLERSDGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CR85</accession>
    <name>A0A177CR85_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1172051</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG09478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039843.1">
        <property type="nucleotide sequence ID" value="XM_018179950.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CR85"/>
    <dbReference type="GeneID" id="28763436"/>
    <dbReference type="InParanoid" id="A0A177CR85"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG09478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="379" mass="41192" checksum="B8B533125161B56A" modified="2016-09-07" version="1">MARIARRVSSITCRGRGASRGRVWPACAGRIPGIWSNTAMQQNLGSPVSPDCGPALTASRAEGRGTWSSRADVREALVKAGVSVPPLDVCVCSEQRILHPPLSPASRTSGQRRVHHRRCERRDGQRPGLRGPCYGPPHIAIGATYGCSWHLPKARVLVMPLPLIRRVYRDCAALVHSTDVWMQRQGPRCILQCPVNAALRGPRAVVPTLAGSRGWDGGARVGVPEAASLRDDKRETEPSICGSGWACFWAAGDLLLILHCNRYQRRWIGSRAGCLECGSARWSLLCHSTGGRNDRKKAPPSIRPRRRANRAIARLFRGTSQTIAPVQWAMGQSVATPSPRERRPYQLHIAGLARGQTKPGQANGAAVRASLVLTPTTIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CR97</accession>
    <name>A0A177CR97_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1184194</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040409.1">
        <property type="nucleotide sequence ID" value="XM_018180731.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CR97"/>
    <dbReference type="STRING" id="1460663.A0A177CR97"/>
    <dbReference type="GeneID" id="28764217"/>
    <dbReference type="InParanoid" id="A0A177CR97"/>
    <dbReference type="OrthoDB" id="542013at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157:SF31">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG10044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="332" mass="36152" checksum="DCA93FDDE9640F5F" modified="2016-09-07" version="1">MSIPQILGEGLFAKLPVLVNEDTCAGKTYIITGGNHGLGLETARHLVRSFAARVILTVRNMKAGENAKADIERATGRTGVIELWDLDLASYDSIKAFASKLCSDTGRIDAFIANAGVQMDRWESAQGMELSMQVNVISTMLLAVLILPKLMESANSYRNEPKLVFVGSALGFVAKEDLAKCGQANVFAALNEPTRANMDQRYALTKLVEHYAIRELANLCPVERTCVTINVTAPGLCSTGLGHDTSTKTRAMVSVLRAAFARTAEQGSRTILHGVVAERDSHGKMLSGCKIKEYWVPKWMSDTGGKQMQKQIWSELAKIMEIQQPGCVSKIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CS57</accession>
    <name>A0A177CS57_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Peptidase S54 rhomboid domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CC84DRAFT_1137600</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S54 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG09720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040085.1">
        <property type="nucleotide sequence ID" value="XM_018176154.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CS57"/>
    <dbReference type="STRING" id="1460663.A0A177CS57"/>
    <dbReference type="GeneID" id="28759640"/>
    <dbReference type="InParanoid" id="A0A177CS57"/>
    <dbReference type="OrthoDB" id="10260614at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022764">
        <property type="entry name" value="Peptidase_S54_rhomboid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050925">
        <property type="entry name" value="Rhomboid_protease_S54"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43731:SF14">
        <property type="entry name" value="PRESENILIN-ASSOCIATED RHOMBOID-LIKE PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43731">
        <property type="entry name" value="RHOMBOID PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01694">
        <property type="entry name" value="Rhomboid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="89"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="240"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="267"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S54 rhomboid" evidence="9">
        <location>
            <begin position="195"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="33"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="51"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAG09720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="370" mass="40823" checksum="810D7CC04C127567" modified="2016-09-07" version="1">MSCLRCRAALPPLSAVRSPVGRAARWNQIRQLQTRRSQNAPGHPSKTLPHPTSQSPQSQPATEPHYPPNLNEEGHFPGGGEIPKVKIRFLAPTIWAITVSTGIYVSLAYFTAKSELESKSPYSLFRGNSRGSSYSISTPNGPPTPTEVVTRAWRNADPMSKLSWGLIGVNGAVHLSSLVAPRVWQHLWHIPATNRHYTLFTSTFVHSGLMHLGVNLYALYNFLPATGYSSLFRGDTNHMLSFFLSTGVLSGLAQHFASMIFRQGRAYAPFISSGGASGALFAVFGAFCMEYPTQGVGIILIPYYMEAQYFLPIVMAFDLVGMIRGYSFVQFGHAAHLSGACIGAAYSYLDGHNNAWRPLVDYWKRHLQQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CSN0</accession>
    <name>A0A177CSN0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">COPI associated</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CC84DRAFT_1160999</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG09978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040343.1">
        <property type="nucleotide sequence ID" value="XM_018177632.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CSN0"/>
    <dbReference type="FunCoup" id="A0A177CSN0">
        <property type="interactions" value="50"/>
    </dbReference>
    <dbReference type="GeneID" id="28761118"/>
    <dbReference type="InParanoid" id="A0A177CSN0"/>
    <dbReference type="OrthoDB" id="423534at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013714">
        <property type="entry name" value="Golgi_TVP15"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28128">
        <property type="entry name" value="GOLGI APPARATUS MEMBRANE PROTEIN TVP15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28128:SF1">
        <property type="entry name" value="GOLGI APPARATUS MEMBRANE PROTEIN TVP15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08507">
        <property type="entry name" value="COPI_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAG09978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="131" mass="14155" checksum="B01758647735C00A" modified="2016-09-07" version="1">MDFSDIFRMVNFATAVFMVLGGVTKFIHPGGFANIILGVYLVIFGAATGLLEVQIPPQVTRYASFMFSFIGRGVFYVFVGSVAVGDGWWRIIPGTIVGVVGLAYIVLEFIPSIEPPANMRDADAGWGAEQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CT76</accession>
    <name>A0A177CT76_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Translational machinery component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_1161107</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uL18 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040465.1">
        <property type="nucleotide sequence ID" value="XM_018177654.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CT76"/>
    <dbReference type="FunCoup" id="A0A177CT76">
        <property type="interactions" value="1186"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CT76"/>
    <dbReference type="GeneID" id="28761140"/>
    <dbReference type="InParanoid" id="A0A177CT76"/>
    <dbReference type="OrthoDB" id="1618453at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008097">
        <property type="term" value="F:5S rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00432">
        <property type="entry name" value="Ribosomal_L18_L5e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005485">
        <property type="entry name" value="Rbsml_uL18_euk_arch"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057268">
        <property type="entry name" value="Ribosomal_L18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025607">
        <property type="entry name" value="Ribosomal_uL18_C_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23410:SF12">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23410">
        <property type="entry name" value="RIBOSOMAL PROTEIN L5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14204">
        <property type="entry name" value="Ribosomal_L18_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17144">
        <property type="entry name" value="Ribosomal_L5e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00058">
        <property type="entry name" value="RIBOSOMALL5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53137">
        <property type="entry name" value="Translational machinery components"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL18 C-terminal eukaryotes" evidence="7">
        <location>
            <begin position="164"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="173"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAG10100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="225" mass="25497" checksum="BB78EA1B2FAD93A3" modified="2016-09-07" version="1">MAAYAHELKPYGITHGLTNWSAAYAVGLLLARRTLKKLELDEAFEGVEEADGEFSLTEAAEVDGEERRPFKVFLDVGLVRTSTGARVFGALKGASDGGLYVPHSENRFPGYDIESKELDAETLRKYIFGGHVAEYMETLADDDEERYKSQFSGYIDDDMEADGLEELYQDAHKQIREDPWKKEEGDAPKKSKDEWKKESLKYRTAKLSKAEKEKRVQEKIKTLTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CTV8</accession>
    <name>A0A177CTV8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ER-derived vesicles protein-like protein ERV14</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CC84DRAFT_1203044</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cornichon family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041016.1">
        <property type="nucleotide sequence ID" value="XM_018181802.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CTV8"/>
    <dbReference type="FunCoup" id="A0A177CTV8">
        <property type="interactions" value="841"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CTV8"/>
    <dbReference type="GeneID" id="28765288"/>
    <dbReference type="InParanoid" id="A0A177CTV8"/>
    <dbReference type="OrthoDB" id="434393at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003377">
        <property type="entry name" value="Cornichon"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033466">
        <property type="entry name" value="Cornichon_conserved"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12290">
        <property type="entry name" value="CORNICHON-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03311">
        <property type="entry name" value="Cornichon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01398">
        <property type="entry name" value="Cornichon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01340">
        <property type="entry name" value="CORNICHON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="54"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="111"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAG10651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="138" mass="16199" checksum="E84127F28736B651" modified="2016-09-07" version="1">MSGEAWLYLLAVLINAVNLFLQVFFTIMYSDLECDYINPIDLCNRLNTYIVPEAAVHAFLTFLFLINGYWVALVLNLPLLAWNGKKIFENQHLLDATEIFRKLNVHKKESFIKLGFHLIMFFFYLYSMIVALIRDESH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CTY5</accession>
    <name>A0A177CTY5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_1161563</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041046.1">
        <property type="nucleotide sequence ID" value="XM_018177774.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CTY5"/>
    <dbReference type="GeneID" id="28761260"/>
    <dbReference type="InParanoid" id="A0A177CTY5"/>
    <dbReference type="OrthoDB" id="1149618at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058580">
        <property type="entry name" value="DUF2828"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056690">
        <property type="entry name" value="DUF7788"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011205">
        <property type="entry name" value="UCP015417_vWA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31373">
        <property type="entry name" value="OS06G0652100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31373:SF27">
        <property type="entry name" value="TROVE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11443">
        <property type="entry name" value="DUF2828"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25043">
        <property type="entry name" value="DUF7788"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2828" evidence="2">
        <location>
            <begin position="252"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7788" evidence="3">
        <location>
            <begin position="711"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="349"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="355"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAG10681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="949" mass="105044" checksum="0B16F0A81C3D88AD" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CU75</accession>
    <name>A0A177CU75_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Glycoside hydrolase family 28 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CC84DRAFT_1256782</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Pectinolytic enzyme involved in the degradation of xylogalacturonan (xga), a galacturonan backbone heavily substituted with xylose, and which is one important component of the hairy regions of pectin. Activity requires a galacturonic acid backbone substituted with xylose.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the glycosyl hydrolase 28 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG11095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041460.1">
        <property type="nucleotide sequence ID" value="XM_018184659.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CU75"/>
    <dbReference type="STRING" id="1460663.A0A177CU75"/>
    <dbReference type="GeneID" id="28768145"/>
    <dbReference type="InParanoid" id="A0A177CU75"/>
    <dbReference type="OrthoDB" id="187139at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004650">
        <property type="term" value="F:polygalacturonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000743">
        <property type="entry name" value="Glyco_hydro_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31736">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31736:SF9">
        <property type="entry name" value="ENDO-XYLOGALACTURONAN HYDROLASE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00295">
        <property type="entry name" value="Glyco_hydro_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="10" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 13" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 13 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 14" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008058584" evidence="14">
        <location>
            <begin position="18"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00037278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OAG11095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="412" mass="41999" checksum="F1F898A7B62590DA" modified="2016-09-07" version="1">MLNAVGLISILSSAALAAYAPSNGLFSRSTDGITKRATCTPASAGSSSTDDVPAIEAALKSCGAGGTIIIPAGKTYMIRSTLDLTGCSNCDFQIEGTLKASDDTTFWNGVSSIISVSGISGAKIRSVTGAGVVDGNGQASYDKFASDSSYKRPKLLNIGGKSTNVAVSGLKFKNPPSFFITNNGDSSHISYESLYLTAESKSSNPAKNTDGIDIGPATYTTLKNITIQNTDDCVAFKPGADYVTVDTIHCKGSHGLSVGSLGGSAGKTDTVSNIYVTNAVMEGATKAVGIKVYPGGSSHGTAVVKNVTYDGVTVSSSDYAAQIQSCYNEDASYCASNPSTAQITDVYFKNFKGATSAKYAPTVANINCPAGGTCNVYFSGWAVKAASGTAKFLCANIDNANPGVTCSLGASG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CUH6</accession>
    <name>A0A177CUH6_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Peroxidase</fullName>
            <ecNumber evidence="10">1.11.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CC84DRAFT_1200537</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7 10">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="7 10">Binds 2 calcium ions per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
        <text evidence="7">Binds 1 heme b (iron(II)-protoporphyrin IX) group per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the peroxidase family. Ligninase subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.-" evidence="10"/>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG11194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041559.1">
        <property type="nucleotide sequence ID" value="XM_018181671.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CUH6"/>
    <dbReference type="STRING" id="1460663.A0A177CUH6"/>
    <dbReference type="GeneID" id="28765157"/>
    <dbReference type="InParanoid" id="A0A177CUH6"/>
    <dbReference type="OrthoDB" id="2113341at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000302">
        <property type="term" value="P:response to reactive oxygen species"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.520.10:FF:000021">
        <property type="entry name" value="Peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.420.10">
        <property type="entry name" value="Peroxidase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044831">
        <property type="entry name" value="Ccp1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002016">
        <property type="entry name" value="Haem_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001621">
        <property type="entry name" value="Ligninase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31356:SF66">
        <property type="entry name" value="CATALASE-PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31356">
        <property type="entry name" value="THYLAKOID LUMENAL 29 KDA PROTEIN, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00141">
        <property type="entry name" value="peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00462">
        <property type="entry name" value="LIGNINASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00458">
        <property type="entry name" value="PEROXIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50873">
        <property type="entry name" value="PEROXIDASE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0106">Calcium</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 7" id="KW-0349">Heme</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="7 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 10 12" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007948989" description="Peroxidase" evidence="10">
        <location>
            <begin position="21"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="Plant heme peroxidase family profile" evidence="11">
        <location>
            <begin position="103"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="112"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="251"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="253"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="258"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="8">
        <location>
            <position position="108"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="78"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="99"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR601621-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR601621-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR601621-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR601621-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OAG11194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="340" mass="37009" checksum="FFE3407BE8E8D5F5" modified="2016-09-07" version="1">MFHKALLVLPLLSLASPAFATPLETREASPGLIDGLLTGTLDAIRQSIKDILTGVKSGVADGDISSKPLICLSAVDKCCVWWDVSAELTKRFKETNGECNDAARAAIRFGFHDAGAWDKDTTTGGADGSLMMDFGEIDRPENNGLQSVRLLLREVQALFKVGYADLAQYAHNHATISCPKGPRIRTWVGRKDATGPAPTGKLPDVHDSPDNLIALFERKGFSAHDLAALVGAHAAAKQRFVDTSQAGKPLDTTPGVWDVEFYNDTLQEPQNPDIFVLPSDKKLSVHPKINDEWLSFVGDQPHWNEDYAKAYIRMSLLGVTSAELKGLKDCTKTLPKKTTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CUZ2</accession>
    <name>A0A177CUZ2_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">beta-galactosidase</fullName>
            <ecNumber evidence="3">3.2.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CC84DRAFT_1193992</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.</text>
            <dbReference type="EC" id="3.2.1.23"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the glycosyl hydrolase 35 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.23" evidence="3"/>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040972.1">
        <property type="nucleotide sequence ID" value="XM_018181334.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CUZ2"/>
    <dbReference type="STRING" id="1460663.A0A177CUZ2"/>
    <dbReference type="GeneID" id="28764820"/>
    <dbReference type="InParanoid" id="A0A177CUZ2"/>
    <dbReference type="OrthoDB" id="1657402at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004565">
        <property type="term" value="F:beta-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000040">
        <property type="entry name" value="Beta-galactosidase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.20.10">
        <property type="entry name" value="Beta-galactosidase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.390.10">
        <property type="entry name" value="Beta-galactosidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018954">
        <property type="entry name" value="Betagal_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037110">
        <property type="entry name" value="Betagal_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025972">
        <property type="entry name" value="BetaGal_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036833">
        <property type="entry name" value="BetaGal_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025300">
        <property type="entry name" value="BetaGal_jelly_roll_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031330">
        <property type="entry name" value="Gly_Hdrlase_35_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001944">
        <property type="entry name" value="Glycoside_Hdrlase_35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23421">
        <property type="entry name" value="BETA-GALACTOSIDASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13364">
        <property type="entry name" value="BetaGal_ABD2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10435">
        <property type="entry name" value="BetaGal_dom2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13363">
        <property type="entry name" value="BetaGal_dom3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01301">
        <property type="entry name" value="Glyco_hydro_35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00742">
        <property type="entry name" value="GLHYDRLASE35"/>
    </dbReference>
    <dbReference type="SMART" id="SM01029">
        <property type="entry name" value="BetaGal_dom2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117100">
        <property type="entry name" value="Beta-galactosidase LacA, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008058631" description="beta-galactosidase" evidence="9">
        <location>
            <begin position="20"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-galactosidase" evidence="10">
        <location>
            <begin position="378"/>
            <end position="553"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OAG10607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="976" mass="106883" checksum="D07652BE2B8D2A89" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CVA9</accession>
    <name>A0A177CVA9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Alpha N-terminal protein methyltransferase 1</fullName>
            <ecNumber evidence="5">2.1.1.244</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Translation associated element 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">X-Pro-Lys N-terminal protein methyltransferase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CC84DRAFT_1184664</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>N-terminal L-alanyl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-methionine = N-terminal N,N,N-trimethyl-L-alanyl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:54712"/>
            <dbReference type="Rhea" id="RHEA-COMP:13785"/>
            <dbReference type="Rhea" id="RHEA-COMP:13971"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:138057"/>
            <dbReference type="ChEBI" id="CHEBI:138315"/>
            <dbReference type="EC" id="2.1.1.244"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>N-terminal L-prolyl-L-prolyl-L-lysyl-[protein] + 2 S-adenosyl-L-methionine = N-terminal N,N-dimethyl-L-prolyl-L-prolyl-L-lysyl-[protein] + 2 S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:54736"/>
            <dbReference type="Rhea" id="RHEA-COMP:13787"/>
            <dbReference type="Rhea" id="RHEA-COMP:13974"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:138059"/>
            <dbReference type="ChEBI" id="CHEBI:138318"/>
            <dbReference type="EC" id="2.1.1.244"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>N-terminal L-seryl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-methionine = N-terminal N,N,N-trimethyl-L-seryl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:54724"/>
            <dbReference type="Rhea" id="RHEA-COMP:13789"/>
            <dbReference type="Rhea" id="RHEA-COMP:13973"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:138061"/>
            <dbReference type="ChEBI" id="CHEBI:138317"/>
            <dbReference type="EC" id="2.1.1.244"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. NTM1 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.244" evidence="5"/>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041092.1">
        <property type="nucleotide sequence ID" value="XM_018180766.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CVA9"/>
    <dbReference type="FunCoup" id="A0A177CVA9">
        <property type="interactions" value="482"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CVA9"/>
    <dbReference type="GeneID" id="28764252"/>
    <dbReference type="InParanoid" id="A0A177CVA9"/>
    <dbReference type="OrthoDB" id="1298661at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071885">
        <property type="term" value="F:N-terminal protein N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000025">
        <property type="entry name" value="N-terminal Xaa-Pro-Lys N-methyltransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008576">
        <property type="entry name" value="MeTrfase_NTM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12753">
        <property type="entry name" value="AD-003 - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12753:SF0">
        <property type="entry name" value="ALPHA N-TERMINAL PROTEIN METHYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05891">
        <property type="entry name" value="Methyltransf_PK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016958">
        <property type="entry name" value="DUF858_MeTrfase_lik"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="12">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="144"/>
            <end position="145"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00039112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00039449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00043129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00082558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR016958-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OAG10727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="258" mass="28539" checksum="4C0BB0FB20A745F1" modified="2016-09-07" version="1">MSADPPFPDASAPDALINHDRSIEYWSSVSADTTGMLGGYPQTSRIDLQSSSNFLTKLRRAKSTLPPKQPLPLLDRVADCGAGVGRITKEFLLKVSRRVDVVEPVKKFTDELVQSLGSGEWAGDGDSGAGIARGQVGEVINLGLQDWEPEVGAYDVIWNQWCLGHLTDVQLVAYLRRCKAGITQAEEGARSWIVVKENLSTDFKGKDIYDEEDSSVTRSDEKFRHLFKEAGLKIVATELQKGFPKELFPVRIYALRPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CW25</accession>
    <name>A0A177CW25_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_500650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041294.1">
        <property type="nucleotide sequence ID" value="XM_018186548.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CW25"/>
    <dbReference type="GeneID" id="28770034"/>
    <dbReference type="InParanoid" id="A0A177CW25"/>
    <dbReference type="OrthoDB" id="4225365at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG10929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="384" mass="44150" checksum="50B5D676BB8CE682" modified="2016-09-07" version="1">MRRSILYRALRIILFVWILTVTFWSLLPSPTIPYTQEALNNEKTLKTSHTLIVVDDYPTIYQGSSESNGFGHLIFEWRISRQLNPESEVELTLRVAENDPINLADLMRKSAAFHLSRTKHDAVRTPFFDLTHLDYKVACVDDIKNSDVCLPWFDRSDKALLTHSNHDGTCTISLRIVVDEHGVVELWPASFIENALAQLEKVRLKPEAVDYEEGQLLEETIQFLRESGHPIMQLEGGDMTTLEELHVPYVRGNLPSKTYPIRKAMLVRLGPVLRVALIPVFGIIYLLSTFSTVILFILYNGTLSCAGIMLSAWLRAGRPEFWPWTQRFRLTRWMYFRSQNQKTMWGPAGPVESRSAVRKEWTRNGFVGLERPKTARLERGFNAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CWK0</accession>
    <name>A0A177CWK0_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">MIT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_7207</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG11272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041637.1">
        <property type="nucleotide sequence ID" value="XM_018187156.1"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CWK0"/>
    <dbReference type="GeneID" id="28770642"/>
    <dbReference type="InParanoid" id="A0A177CWK0"/>
    <dbReference type="OrthoDB" id="2245455at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.80">
        <property type="entry name" value="Phosphotransferase system, lactose/cellobiose-type IIA subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007330">
        <property type="entry name" value="MIT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036181">
        <property type="entry name" value="MIT_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37327">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37327:SF1">
        <property type="entry name" value="MICROTUBULE INTERACTING AND TRANSPORT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04212">
        <property type="entry name" value="MIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116846">
        <property type="entry name" value="MIT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MIT" evidence="3">
        <location>
            <begin position="335"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="114"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="454"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="500"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="734"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="776"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="937"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1173"/>
            <end position="1196"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="652"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="18"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="48"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="143"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="159"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="187"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="289"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="322"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="535"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="553"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="740"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="792"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1177"/>
            <end position="1190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAG11272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="1342" mass="144396" checksum="6881F8A769590266" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CYH0</accession>
    <name>A0A177CYH0_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tat pathway signal sequence</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1134048</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ustYa family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG11897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042262.1">
        <property type="nucleotide sequence ID" value="XM_018176009.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CYH0"/>
    <dbReference type="STRING" id="1460663.A0A177CYH0"/>
    <dbReference type="GeneID" id="28759495"/>
    <dbReference type="InParanoid" id="A0A177CYH0"/>
    <dbReference type="OrthoDB" id="3687641at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021765">
        <property type="entry name" value="UstYa-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365:SF14">
        <property type="entry name" value="TAT PATHWAY SIGNAL SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365">
        <property type="entry name" value="YALI0B05434P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11807">
        <property type="entry name" value="UstYa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00035112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG11897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="207" mass="24176" checksum="E4FE47D5D8050335" modified="2016-09-07" version="1">MHEHTYEAPFFNSPYSIYRGPPSPEVDAAWEAIEYPAQMHFSREEIIKLGKDPEAAAKLPEEWGYGADRYFGVLDGQHLIHCVNLLRQWSHFDYYFPKYTPQSQAPPLASAHKDHCVAVLLEHLTCQPSLNVFTYYWMEGQPDPYPNFEINRKCQNHRDLLEWQREREVAPEFRELSFERPEGAKVRPADPRLAMVEGWVWNGSAPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CZ94</accession>
    <name>A0A177CZ94_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Methionine aminopeptidase 2</fullName>
            <shortName evidence="8">MAP 2</shortName>
            <shortName evidence="8">MetAP 2</shortName>
            <ecNumber evidence="8">3.4.11.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Peptidase M</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CC84DRAFT_1183387</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 9">Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8 9">
            <text>Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.</text>
            <dbReference type="EC" id="3.4.11.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="8">Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the peptidase M24A family. Methionine aminopeptidase eukaryotic type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.18" evidence="8"/>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018043219.1">
        <property type="nucleotide sequence ID" value="XM_018180684.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CZ94"/>
    <dbReference type="STRING" id="1460663.A0A177CZ94"/>
    <dbReference type="GeneID" id="28764170"/>
    <dbReference type="InParanoid" id="A0A177CZ94"/>
    <dbReference type="OrthoDB" id="7848262at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004239">
        <property type="term" value="F:initiator methionyl aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01088">
        <property type="entry name" value="MetAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03175">
        <property type="entry name" value="MetAP_2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050247">
        <property type="entry name" value="Met_Aminopeptidase_Type2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001714">
        <property type="entry name" value="Pept_M24_MAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002468">
        <property type="entry name" value="Pept_M24A_MAP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00501">
        <property type="entry name" value="met_pdase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45777">
        <property type="entry name" value="METHIONINE AMINOPEPTIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45777:SF1">
        <property type="entry name" value="METHIONINE AMINOPEPTIDASE 2-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00599">
        <property type="entry name" value="MAPEPTIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="4 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 8 9" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M24" evidence="11">
        <location>
            <begin position="142"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="11"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="42"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="53"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="68"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="210"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="311"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="319"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="344"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="439"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="439"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OAG12854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="458" mass="50311" checksum="41E1601BAED286E6" modified="2016-09-07" version="1">MGAKTPDGHQQGPNESAAHSTIASINPPKPAAASGLLQGTLEGEDEDGDDDDAKCGADGEVTDAKEGQKKKRKRNKKKKGKVPVHQTIPPRVALSNLFPDMQFPAGEVVNRVVEENLQRTTAEEIRHQAILDDMDDEFLSDYRKAAEVHRQVRKHVQTIAKPGITMTELAQEIEDGVRALVGHPGLETGDALRAGMGFPTGLCLNHIAAHWTPNFGNKEVVLKNDDVLKIDFGVHVGGRIVDSAFTLAFNPVYDPLLEAVRATTNTGLKEAGVDARMDHLSEVMQEVMESHEVEIEGKTVPVKAVRNITGHNILRYKIHGDKQVPFYKTKTNQRMEEGDIFAIETFGTTGKARMMDDIGIYGYGRNQNVSTAGLHHASAKSLLKTIDANFGSIVFAKRYLERIGVKNYHLGMRSLVQHGVVESYAPLVDIPGSYVAQFEHTVLLRPNCKEIVSRGDDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177D0P3</accession>
    <name>A0A177D0P3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1171464</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018043162.1">
        <property type="nucleotide sequence ID" value="XM_018179914.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177D0P3"/>
    <dbReference type="GeneID" id="28763400"/>
    <dbReference type="InParanoid" id="A0A177D0P3"/>
    <dbReference type="OrthoDB" id="5419608at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008058851" evidence="2">
        <location>
            <begin position="18"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG12797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="187" mass="17931" checksum="6B5877AD5016837C" modified="2016-09-07" version="1">MQFYAVVLAAMAAAVSAQFPTNIDPAQQSALLALATALPPSVLAAAATNQAGFASEVASSIAAGNTPEWYQALPTDVKSALASIYPVSTSAEATPSETAAPSSSSYEASSVAETTAAVTSTPVVVPSGTGASSIGTNSTGVTSVNTPTLSGTGSPQPTEAPGAASVPSAAIGAGIAGALAFLGMLAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177D0U3</accession>
    <name>A0A177D0U3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">E3 ubiquitin-protein ligase PEP5</fullName>
            <ecNumber evidence="9">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CC84DRAFT_1159902</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the homotypic vacuole fusion and vacuole protein sorting (HOPS) complex. Component of the class C core vacuole/endosome tethering (CORVET) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Endomembrane system</location>
            <topology evidence="8">Peripheral membrane protein</topology>
            <orientation evidence="8">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Vacuole membrane</location>
            <topology evidence="9">Peripheral membrane protein</topology>
            <orientation evidence="9">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the VPS11 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="9"/>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042984.1">
        <property type="nucleotide sequence ID" value="XM_018177360.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177D0U3"/>
    <dbReference type="FunCoup" id="A0A177D0U3">
        <property type="interactions" value="579"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177D0U3"/>
    <dbReference type="GeneID" id="28760846"/>
    <dbReference type="InParanoid" id="A0A177D0U3"/>
    <dbReference type="OrthoDB" id="26184at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033263">
        <property type="term" value="C:CORVET complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030897">
        <property type="term" value="C:HOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007032">
        <property type="term" value="P:endosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048284">
        <property type="term" value="P:organelle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007033">
        <property type="term" value="P:vacuole organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006904">
        <property type="term" value="P:vesicle docking involved in exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16688">
        <property type="entry name" value="RING-H2_Vps11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000440">
        <property type="entry name" value="E3 ubiquitin-protein ligase PEP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:001145">
        <property type="entry name" value="E3 ubiquitin-protein ligase PEP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057308">
        <property type="entry name" value="CHCR_PEP5_VPS11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000547">
        <property type="entry name" value="Clathrin_H-chain/VPS_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057307">
        <property type="entry name" value="PEP5_VPS11_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016528">
        <property type="entry name" value="VPS11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024763">
        <property type="entry name" value="VPS11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23323">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23323:SF24">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 11 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23341">
        <property type="entry name" value="PEP5_VPS11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23356">
        <property type="entry name" value="TPR_PEP5_VPS11"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12451">
        <property type="entry name" value="VPS11_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17122">
        <property type="entry name" value="zf-C3H2C3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007860">
        <property type="entry name" value="VPS11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50236">
        <property type="entry name" value="CHCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <keyword evidence="9" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="9" id="KW-0926">Vacuole</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="repeat" description="CHCR" evidence="11">
        <location>
            <begin position="329"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="13">
        <location>
            <begin position="808"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="537"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="537"/>
            <end position="557"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR007860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OAG12619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="902" mass="101143" checksum="D3A1A3060CDB0687" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177D1Q1</accession>
    <name>A0A177D1Q1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_1171706</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG13102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018043467.1">
        <property type="nucleotide sequence ID" value="XM_018179925.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177D1Q1"/>
    <dbReference type="FunCoup" id="A0A177D1Q1">
        <property type="interactions" value="69"/>
    </dbReference>
    <dbReference type="GeneID" id="28763411"/>
    <dbReference type="InParanoid" id="A0A177D1Q1"/>
    <dbReference type="OrthoDB" id="10021397at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000196">
        <property type="entry name" value="MFS toxin efflux pump (AflT)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1720.10:FF:000012">
        <property type="entry name" value="MFS toxin efflux pump (AflT)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF198">
        <property type="entry name" value="AZOLE RESISTANCE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="193"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="259"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="284"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="316"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="347"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="388"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="419"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="456"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="497"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="523"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="553"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="587"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="654"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="194"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="94"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="98"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="156"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="171"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAG13102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="692" mass="74391" checksum="D440085009B81591" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177D1V9</accession>
    <name>A0A177D1V9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_175961</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG13029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018043394.1">
        <property type="nucleotide sequence ID" value="XM_018185461.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177D1V9"/>
    <dbReference type="GeneID" id="28768947"/>
    <dbReference type="InParanoid" id="A0A177D1V9"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008058886" description="Secreted protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG13029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="170" mass="19011" checksum="7F340B9CCBE0E15D" modified="2016-09-07" version="1">MLSASLLLSCVILLVRFRASIVYIQEDCTPMLSARRYALPTALAQRIPDQRTNMAKSDRFCKIDWLTQATHLPTGLACIMQSRVHWSEVRSLSTVGCTEYAQGRRINVDPPQATRSADPSFDGLDVASARRESSTFLHHSSGSSYRLCRVRISAPTPTSWTWWLIVGPVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BUY2</accession>
    <name>A0A177BUY2_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1191449</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441563">
        <property type="protein sequence ID" value="OAF98955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029321.1">
        <property type="nucleotide sequence ID" value="XM_018181182.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BUY2"/>
    <dbReference type="GeneID" id="28764668"/>
    <dbReference type="InParanoid" id="A0A177BUY2"/>
    <dbReference type="OrthoDB" id="62952at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038883">
        <property type="entry name" value="AN11006-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085:SF8">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAF98955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="416" mass="47803" checksum="70525F64F022E3AF" modified="2016-09-07" version="1">MGLGASLAGSAESVCRKDVFPFLELPRELRDQIYDYAFNIPEDRADRALRIERRHLKYFRPSAASILLVLHHEYFLLNRQIAREALGLLFKNHTVYLSCGPYVLKQLLSRIEATGGPGKRWLKRIKRIELDWVTFPNLRIYPPERSEGKDEWYWEHDNHEVDVDYIRGAQYSGHYDEHDYEGGYYDDNFYEAEDASLYPTWPGRSTAAAAANPNDPFGFSTHYPFADPARPDAVTASDIDSKLDLLVSLEVTPLFDYLASPAFALNSITLPLYFLSRASQHQRTVSRPGYTLPLKIRYWVHNCIHALLMLRDSDTLQEVRVKYIPWDVWASMEPADDLRRMVEMGVWFRGSEEGSGEREGEGEAFRAVWAGLAGKGACNGDERMGLRAEVRFVKWEFDLDKRVGDELEVVFTKGVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BVN3</accession>
    <name>A0A177BVN3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">General stress protein FMN-binding split barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1130292</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441561">
        <property type="protein sequence ID" value="OAF99543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029909.1">
        <property type="nucleotide sequence ID" value="XM_018175855.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BVN3"/>
    <dbReference type="STRING" id="1460663.A0A177BVN3"/>
    <dbReference type="GeneID" id="28759341"/>
    <dbReference type="InParanoid" id="A0A177BVN3"/>
    <dbReference type="OrthoDB" id="434253at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052917">
        <property type="entry name" value="Stress-Dev_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038725">
        <property type="entry name" value="YdaG_split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34818">
        <property type="entry name" value="PROTEIN BLI-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34818:SF1">
        <property type="entry name" value="PROTEIN BLI-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16242">
        <property type="entry name" value="Pyrid_ox_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="General stress protein FMN-binding split barrel" evidence="2">
        <location>
            <begin position="31"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAF99543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="205" mass="22663" checksum="903FB1D8AE3BB753" modified="2016-09-07" version="1" fragment="single">MPETLNQGEVNSHTDPSVAKQYDNDTPKEQQIKDLYNMIDGKKIGMLSTYRNGVGPVGRSMAVGKRVGPDILFLSNGHSSKFSDLSENKECQVTFQDSKTQDWISLSGTATTVSNTDARIKDVWSSPIRAWFGDLGDGKHDGSADDPRMTLIEFRPKYVVYYLTQVGLLGYMKEVGVAAMTGKIADTGVIRELDEKDIEMARGMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BVS3</accession>
    <name>A0A177BVS3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_1181925</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441564">
        <property type="protein sequence ID" value="OAF98768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029134.1">
        <property type="nucleotide sequence ID" value="XM_018180581.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BVS3"/>
    <dbReference type="GeneID" id="28764067"/>
    <dbReference type="InParanoid" id="A0A177BVS3"/>
    <dbReference type="OrthoDB" id="2250022at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000057">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF12">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="155"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="187"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="219"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="287"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="321"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="353"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="379"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="412"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="443"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="59"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAF98768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="486" mass="54174" checksum="436FCF7328B5DD6C" modified="2016-09-07" version="1">MATTTTAEKNEVLMLEQQQTNEPDYVKPVPIVDKQDQFGAHEKTDPREIALVKKLDRWIMPMLWSMYWLNYLDRNAIALARINDLEEDLNLTSAQYQTCVSILFVGYLLGQIPSNMFLTRTRPSRYMGTAMMLWAIVSGLTAVSKNFTGLLLTRFFLGLTEAPYYPGAVYLLSIFYTRKEVATRIAILYTGNILATAFAGLIAAGIFHGMDDVAGLSGWRWLFILQGAVTFVIAIVGFFLLPDFPHDTKWLTPEERLLATNRMELDTVGNEGETSTRKGFMQAAKDPMVWIFAFMAHMHLAANGFKNFFPTVVETLGFEETITLVLTCPPYLIAGAVTIAVSWSSGKFNERTWHITISKAVATIGFVSACATMDVAGRYVSMVIFTIGTYGVNSLILGWCGSTCGQTKEKKAVAIGIVTTIMNASFIWTPYLWPKTDEPRYAIALGSSAGFSVATAVLAWVAKIIMKRRNKALREMNDESGNFYVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BW51</accession>
    <name>A0A177BW51_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1264196</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441562">
        <property type="protein sequence ID" value="OAF99180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029546.1">
        <property type="nucleotide sequence ID" value="XM_018185291.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BW51"/>
    <dbReference type="GeneID" id="28768777"/>
    <dbReference type="InParanoid" id="A0A177BW51"/>
    <dbReference type="OrthoDB" id="4738875at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052523">
        <property type="entry name" value="Trichothecene_AcTrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791">
        <property type="entry name" value="GNAT FAMILY ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791:SF1">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13673">
        <property type="entry name" value="Acetyltransf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008057418" description="N-acetyltransferase domain-containing protein" evidence="1">
        <location>
            <begin position="30"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetyltransferase" evidence="2">
        <location>
            <begin position="117"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAF99180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="274" mass="30347" checksum="4976915CB3E28E8D" modified="2016-09-07" version="1">MRTQCKLQPRLGLLLTLVVLTLHVAATAAGEQQVLNDSPHAGLRLRNATINDAAAIANVTIAAFFDLPNWDYLYQFRREYPREHQRCMTQFTNRILAHPAGRGEVVEIEAGADGERVVIASALWLQLQLQCALAEAGGEEPIPVGALSEEMANCTHRDLNLTRAVAWDHQWNALARKNLAPFGGNQLYLELLGTHPAYQGRGAGSILVKSGLERARKEMEEGELDVNVTLIAQPTAETFYMGMGFKEMRNMTMEGVDGESFVFNVMAYDMQSED</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BW52</accession>
    <name>A0A177BW52_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1170028</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441566">
        <property type="protein sequence ID" value="OAF98559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018028925.1">
        <property type="nucleotide sequence ID" value="XM_018179819.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BW52"/>
    <dbReference type="GeneID" id="28763305"/>
    <dbReference type="InParanoid" id="A0A177BW52"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAF98559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="74" mass="7936" checksum="729891DEFBE0A5C9" modified="2016-09-07" version="1">MSKKRYTCFAVCVLHIAIPIPGGSNWSSQQWRVNILILSGACSCTPIATLQSAARCSVVSPLPVPLAQSFIPSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BWA3</accession>
    <name>A0A177BWA3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Alpha-1,3-glucosyltransferase</fullName>
            <ecNumber evidence="10">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CC84DRAFT_1157775</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2 10">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Endoplasmic reticulum membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the ALG6/ALG8 glucosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="10"/>
    <dbReference type="EMBL" id="KV441563">
        <property type="protein sequence ID" value="OAF98948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029314.1">
        <property type="nucleotide sequence ID" value="XM_018177030.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BWA3"/>
    <dbReference type="FunCoup" id="A0A177BWA3">
        <property type="interactions" value="961"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177BWA3"/>
    <dbReference type="GeneID" id="28760516"/>
    <dbReference type="InParanoid" id="A0A177BWA3"/>
    <dbReference type="OrthoDB" id="5589195at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042281">
        <property type="term" value="F:dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004856">
        <property type="entry name" value="Glyco_trans_ALG6/ALG8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12413">
        <property type="entry name" value="DOLICHYL GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12413:SF1">
        <property type="entry name" value="DOLICHYL PYROPHOSPHATE MAN9GLCNAC2 ALPHA-1,3-GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03155">
        <property type="entry name" value="Alg6_Alg8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="57"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="159"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="192"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="255"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="280"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="380"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="408"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="448"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="481"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="544"/>
            <end position="569"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OAF98948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="584" mass="65720" checksum="AFC394C70F715EC6" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BWP9</accession>
    <name>A0A177BWP9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">FAD/NAD(P)-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CC84DRAFT_1155831</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FMO family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441560">
        <property type="protein sequence ID" value="OAF99913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030279.1">
        <property type="nucleotide sequence ID" value="XM_018176952.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BWP9"/>
    <dbReference type="FunCoup" id="A0A177BWP9">
        <property type="interactions" value="631"/>
    </dbReference>
    <dbReference type="GeneID" id="28760438"/>
    <dbReference type="InParanoid" id="A0A177BWP9"/>
    <dbReference type="OrthoDB" id="66881at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000960">
        <property type="entry name" value="Flavin_mOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050346">
        <property type="entry name" value="FMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23023">
        <property type="entry name" value="DIMETHYLANILINE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00370">
        <property type="entry name" value="FMOXYGENASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="461"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="461"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAF99913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="502" mass="56816" checksum="E1E35278E0086561" modified="2016-09-07" version="1">MATKSRIKSVAVIGAGAAGAATAAALNAENYFERIQVFERRETAGGTWIYDADPDPLPLYPGKLPPDTDPALEIPEALPRITPPIEQERWTKTPIYNSLTTNVPAIAMSFSDSPFAYGPFAPHYVPRQYVENYFSIHKTDSLLQLNTTVEDITKLPSSNGQSSERWKLTLRKHDALRRVDIWWEEEFDAVILANGHYAVPYIPQVKGLEEYIAMYPDRISHSKEYRAPAIYAGRKVLVIGNSASGHDVSLDLVGVANAPVYQSRRSKARWDGDGPLSGIEWKPLIREYLPSGRIIFEDDSYLDDIDAVLYCTGYKPSFPFWNVKTNGRPLWDYEANKLIKTYWHTFFQDFETLAIVGMPRTLTFRSFEYQAIAIARLFAGRNALPLPRLKEQEKWEMDRARRTKAEGKKFHDIPWDEGQTIEWLDGLFRIAGLGTIRGEGLVPPALSKELIWAVEHLRKYPEDPDEHGEKGNDEDHAGRREGSEGGWVVVQREKLPLGGVLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BWX7</accession>
    <name>A0A177BWX7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1063699</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441560">
        <property type="protein sequence ID" value="OAF99912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030278.1">
        <property type="nucleotide sequence ID" value="XM_018173614.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BWX7"/>
    <dbReference type="STRING" id="1460663.A0A177BWX7"/>
    <dbReference type="GeneID" id="28757100"/>
    <dbReference type="InParanoid" id="A0A177BWX7"/>
    <dbReference type="OrthoDB" id="537467at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAF99912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="91" mass="10537" checksum="5F3C4CBFA1CD1F89" modified="2016-09-07" version="1" fragment="single">MTKPCTLCSTPRSILVRCQIDETHQWHFLCPGACWKSVSGGVEDARGLEDEHPYYRYGGMWKDRSADGPVSAKKPRKVKKRQREEARDREE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BXU5</accession>
    <name>A0A177BXU5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_297650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441559">
        <property type="protein sequence ID" value="OAG00344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030709.1">
        <property type="nucleotide sequence ID" value="XM_018185782.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BXU5"/>
    <dbReference type="STRING" id="1460663.A0A177BXU5"/>
    <dbReference type="GeneID" id="28769268"/>
    <dbReference type="InParanoid" id="A0A177BXU5"/>
    <dbReference type="OrthoDB" id="5357075at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="77"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG00344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="335" mass="37829" checksum="3505ACC6725F6438" modified="2016-09-07" version="1">MQPLLIHFCDLCSTSTAIPFSASVFSQNNSCSHCGALSTGINIKTCGKQQESNMQQDELAQLFSAHMRLSQNRNNGSQDSQVAPQQQPAQQQEQVSQPIIYASQHYTHSYHVAPTRQLDPESEKTHIEPSELHGVLLRNSIDPTLLFPSQIDLFQNADNDQRLRLLELWRISPPSGSTARQLYDWPPTSLAQEEAMAKLRYERMIEERVQQDEIQKHQQQLDQSMDQSTDTAAVQAARDILVGSPDTAAEPYIVSGYDMLARREYEESAKSAGNYLRESTSYNQATDPVYIHTGQTGLWEKNVGSILDMENQYGAFAHARDFDVHRTYGDDEMVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BZU5</accession>
    <name>A0A177BZU5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_271467</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441558">
        <property type="protein sequence ID" value="OAG00903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031268.1">
        <property type="nucleotide sequence ID" value="XM_018185686.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BZU5"/>
    <dbReference type="GeneID" id="28769172"/>
    <dbReference type="InParanoid" id="A0A177BZU5"/>
    <dbReference type="OrthoDB" id="3797248at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="55"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG00903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="120" mass="12294" checksum="7FA56B6BCA5E3D97" modified="2016-09-07" version="1">MSSGRLHIPFPRTFLSVNTPTKKAGSPVEPTAAPEPQQSAHSFLSNRPAGAQRHASVSSVSSVDSIASAASATRGSPPASPVLEQTLPAFLSLNAKYAAPPKTAAALSGAEPHGFLSNRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BZV3</accession>
    <name>A0A177BZV3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">pectin lyase</fullName>
            <ecNumber evidence="7">4.2.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CC84DRAFT_1103224</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>Eliminative cleavage of (1-&gt;4)-alpha-D-galacturonan methyl ester to give oligosaccharides with 4-deoxy-6-O-methyl-alpha-D-galact-4-enuronosyl groups at their non-reducing ends.</text>
            <dbReference type="EC" id="4.2.2.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the polysaccharide lyase 1 family.</text>
    </comment>
    <dbReference type="EC" id="4.2.2.10" evidence="7"/>
    <dbReference type="EMBL" id="KV441560">
        <property type="protein sequence ID" value="OAF99976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030342.1">
        <property type="nucleotide sequence ID" value="XM_018175001.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BZV3"/>
    <dbReference type="STRING" id="1460663.A0A177BZV3"/>
    <dbReference type="GeneID" id="28758487"/>
    <dbReference type="InParanoid" id="A0A177BZV3"/>
    <dbReference type="OrthoDB" id="1637350at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030570">
        <property type="term" value="F:pectate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047490">
        <property type="term" value="F:pectin lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.10:FF:000003">
        <property type="entry name" value="Pectin lyase F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002022">
        <property type="entry name" value="Pec_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045032">
        <property type="entry name" value="PEL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31683">
        <property type="entry name" value="PECTATE LYASE 18-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31683:SF16">
        <property type="entry name" value="PECTIN LYASE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00656">
        <property type="entry name" value="Amb_all"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008057525" description="pectin lyase" evidence="8">
        <location>
            <begin position="17"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="Pectate lyase" evidence="9">
        <location>
            <begin position="99"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00036818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00039082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAF99976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="376" mass="38918" checksum="4035A2CD282C9341" modified="2016-09-07" version="1">MQRFVIALLGASAALAAPTASIKRATVSGSAEGFAAGVTGGGDATAVTPTSTDELVSYLGDSEPRVIILNQEFDFTDSEGTTTSAGCSPWGTGSQCQIAINQNDWCTNYEPDAPTVSSITYNKAGVEGITVASDKTIIGEGSKGVIKGKGLRMANGVSNIIIQNIHVTEINPEYVWGGDGITIDGADMIWIDHVKTSLIGRQHIVLGTESSGKVTISNSEIDGTTSWSAQCNAYHYWSVLFLGSDDQVTFKGNYIHNTSGRGPKVGGKTVLHAVNNYWGNIDPTGHAFEIDSGAYILAEGNTFDSVKTPVSTLEGKLYTGTDCSSALGRACVENTLTGSGDFSGTASDVLSSFSSKAAAADKDASGVPSSAGIGKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BZX9</accession>
    <name>A0A177BZX9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">FMN dependent dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CC84DRAFT_1046473</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441559">
        <property type="protein sequence ID" value="OAG00716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031081.1">
        <property type="nucleotide sequence ID" value="XM_018173419.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BZX9"/>
    <dbReference type="STRING" id="1460663.A0A177BZX9"/>
    <dbReference type="GeneID" id="28756905"/>
    <dbReference type="InParanoid" id="A0A177BZX9"/>
    <dbReference type="OrthoDB" id="25826at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000132">
        <property type="entry name" value="FMN dependent dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012133">
        <property type="entry name" value="Alpha-hydoxy_acid_DH_FMN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000262">
        <property type="entry name" value="FMN-dep_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037396">
        <property type="entry name" value="FMN_HAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008259">
        <property type="entry name" value="FMN_hydac_DH_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578:SF143">
        <property type="entry name" value="FMN-DEPENDENT ALPHA-HYDROXY ACID DEHYDROGENASE PB1A11.03"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578">
        <property type="entry name" value="S -2-HYDROXY-ACID OXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01070">
        <property type="entry name" value="FMN_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000138">
        <property type="entry name" value="Al-hdrx_acd_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00557">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51349">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 7" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN hydroxy acid dehydrogenase" evidence="8">
        <location>
            <begin position="15"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="290"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="95"/>
            <end position="97"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="149"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="266"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="288"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="290"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="293"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="321"/>
            <end position="325"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="344"/>
            <end position="345"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000138-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000138-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAG00716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="395" mass="43326" checksum="1F109A4407943593" modified="2016-09-07" version="1" fragment="single">YDYEMDTYQKGLQYGRPPLTFQASKWESLACERMSAESKGYVHGSAGSRETDDKNKSAFKKWSIVPKRLTGHKQFPDLTTEIFGEKLQVPIAMAPVGVLRIFNPEGEVAATKAAAKEAVPYILSTAASTSIEDVAEANGEDGQRWYQLYWPNRGNDNITISLLQRAKKAGYTALFVTLDTYLLGWRPSDMDNGYNPFLRADQIGVALGFSDPVYRQKFKEQHGVEIEEKMGEAAAGWMRTIFNGFSHSWEDLKFLQEHWDGPIVLKGIQTIADAKKAAEIGIQGIVVSNHGGRQQDGGNSSLGMLPHIVDAVGDKLKIFFDSGIRCGADIAKALALGADCVLVGRPYVYGLTLGGEGGVTHVLKSLIGDLELTLHIAGIPSVSKKDLNREVLVRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C0B1</accession>
    <name>A0A177C0B1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1056346</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441558">
        <property type="protein sequence ID" value="OAG00846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031211.1">
        <property type="nucleotide sequence ID" value="XM_018173542.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C0B1"/>
    <dbReference type="STRING" id="1460663.A0A177C0B1"/>
    <dbReference type="GeneID" id="28757028"/>
    <dbReference type="InParanoid" id="A0A177C0B1"/>
    <dbReference type="OrthoDB" id="661148at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG00846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="174" mass="20089" checksum="AE4E052D9DC0E326" modified="2016-09-07" version="1" fragment="single">WTYNLKFDNMTGMRKSELLTPPNQIDLITTYLPAKNYDSLRFIGPDGNVFLWVAHAPLSSVHGARYDALRHALFMAPKGCDPLYGNIVADHAYWDGFIDYSESTCTFTLVNLPDEALYIRTSAVDPALICATLQIMRDWEFHMLRVQRHRDPNGFRISEDRAREGDLGRITYWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2023-06-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C0B9</accession>
    <name>A0A177C0B9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1168739</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441559">
        <property type="protein sequence ID" value="OAG00681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031046.1">
        <property type="nucleotide sequence ID" value="XM_018179471.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C0B9"/>
    <dbReference type="GeneID" id="28762957"/>
    <dbReference type="InParanoid" id="A0A177C0B9"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG00681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="52" mass="5478" checksum="F5389474F7AACD9A" modified="2016-09-07" version="1">MHVPSPSVASGAKVGMWLTLTRVSGAAAGLREDVLRLAGLRDWLFRTAPSAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C0Z7</accession>
    <name>A0A177C0Z7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PLP-dependent transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CC84DRAFT_1199169</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441558">
        <property type="protein sequence ID" value="OAG01165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031530.1">
        <property type="nucleotide sequence ID" value="XM_018181605.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C0Z7"/>
    <dbReference type="STRING" id="1460663.A0A177C0Z7"/>
    <dbReference type="GeneID" id="28765091"/>
    <dbReference type="InParanoid" id="A0A177C0Z7"/>
    <dbReference type="OrthoDB" id="7042322at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050478">
        <property type="entry name" value="Ethylene_sulfur-biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43795">
        <property type="entry name" value="BIFUNCTIONAL ASPARTATE AMINOTRANSFERASE AND GLUTAMATE/ASPARTATE-PREPHENATE AMINOTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43795:SF63">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_4G00630)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00753">
        <property type="entry name" value="ACCSYNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="4">
        <location>
            <begin position="72"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="10"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAG01165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="439" mass="48599" checksum="2AC198B13512AED1" modified="2016-09-07" version="1">MTESLLSSRGQKELTDGADEHQVWEVSANQWDPETNPNGYVSLGIAENSLSHDELAEFLRNKSLIDPSAKAFTYQDGPAGSKPARNAIASFFNTYFHPIQQVRADNIIITNGASSAIEHCAWALCNSGEGILLGRPYYRAFLPDIQTRFGVKVVPVAFGEVDPCGLDCVARYEEALLRSNADGVKVRALLLCNPHNPLGRCYSKATIVQLMLLCQKYQMHLISDEIYALSVWENTVDKLEAPPTPFESALSIDTREIIDAALVHVLWGFSKDFGANGIRIGVMISQHNEPFLTACQTACIYSSPSSLAENAVVTILSDPNFLASYIRTNSERMSAAYTYAVQLLRRYDIDYIPGANAAFFLWINLGKRYLQVLGDSARGKSMDAFTNEIFQLLMKKKVYLVLGDAAGAEQPGWFRMVFTQPPRSVEEGLKRISEALNGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C132</accession>
    <name>A0A177C132_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">4-coumarate-CoA ligase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CC84DRAFT_1230462</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441559">
        <property type="protein sequence ID" value="OAG00427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030792.1">
        <property type="nucleotide sequence ID" value="XM_018183695.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C132"/>
    <dbReference type="STRING" id="1460663.A0A177C132"/>
    <dbReference type="GeneID" id="28767181"/>
    <dbReference type="InParanoid" id="A0A177C132"/>
    <dbReference type="OrthoDB" id="1898221at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016405">
        <property type="term" value="F:CoA-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000007">
        <property type="entry name" value="4-coumarate--CoA ligase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096:SF149">
        <property type="entry name" value="AMP-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="3">
        <location>
            <begin position="86"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="4">
        <location>
            <begin position="479"/>
            <end position="555"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAG00427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="573" mass="62190" checksum="0C2A10074F199990" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C1U9</accession>
    <name>A0A177C1U9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1229345</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441558">
        <property type="protein sequence ID" value="OAG00822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031187.1">
        <property type="nucleotide sequence ID" value="XM_018183663.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C1U9"/>
    <dbReference type="GeneID" id="28767149"/>
    <dbReference type="InParanoid" id="A0A177C1U9"/>
    <dbReference type="OrthoDB" id="10645640at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG00822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="378" mass="42950" checksum="024EBFB10B65F18E" modified="2016-09-07" version="1">MEAHVQQSDELTFALDDWSQFEGAPSLILPEIDRQLFETLAQEMAVWESNIASPPQAPTPYCLQAMHVPREHSWQPAEHTVMTDEGLPQFDATSLDGSVTSQQLIPNVQRVVAIEKGQNRCPLCNKTFRRGGSAVRAHINCVHIGKRKEHIRLNSSRAGRPKAQPSPRVSTPGQKNGRDTQRRSRVLSEITNLRSSVQDYITLAEFRTLQYELVVLKQERRMLLDSMGIWAQCDETFQQIIKDEAGAEFTAIERRALARDQSRRLVCTFQISFLTIMLEASRASQMQVRGRLVSRLEDMAAGKDKLLSNMEEAKVLRDFLSSVEDWVAAIQGRTTSLAFDYVVEMLVIKLICLLYPRLSKGLFQPTPEELEAQRREIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C1W4</accession>
    <name>A0A177C1W4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cytochrome P450 pisatin demethylase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1154220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441558">
        <property type="protein sequence ID" value="OAG00879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031244.1">
        <property type="nucleotide sequence ID" value="XM_018176874.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C1W4"/>
    <dbReference type="STRING" id="1460663.A0A177C1W4"/>
    <dbReference type="GeneID" id="28760360"/>
    <dbReference type="InParanoid" id="A0A177C1W4"/>
    <dbReference type="OrthoDB" id="3934656at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF229">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="212"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG00879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="434" mass="48851" checksum="72E312C0F622C47E" modified="2016-09-07" version="1">MAILPDTVLGLSPWTWLFKIGPIAIVVYTLLWMVYAVTLHPLAKVPGPFWASVTRIWYMYQVYMGDMDKVQRAMHKKYGPVVRLAPNEVTSANAADIPKIYRLTDPLLKTDFYPIWGAPQISKQPDQFTCIDEKEHTRYRKIVAPVYSLANVLKHEDYVAKCTTLFLERMMEFADKKEQVDIGHWFQMYAFDVVGELSFGNMFGFMEKNTDIGGWIGALEALMPVLCAAAIAPTYLRPFVLGSAIVSPTVFRALKSFEGIHTAAVDVVTKRVKEINAGIADRIDMLQQFSKIVRDKGDQNGFTDNEVTLEAYIAMLAGSDTTAIALRATLYFLMKHPGKLAKCREEIDAHRASLSSPIRYTESLAQLPYTSAAIKEAMRLHPSVGLSMQRHSPKTGVELSGYFIPPGWRRTLMSFSLSDGWSLKREAGKWRSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2023-06-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C2L9</accession>
    <name>A0A177C2L9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1168101</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441558">
        <property type="protein sequence ID" value="OAG00880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031245.1">
        <property type="nucleotide sequence ID" value="XM_018179317.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C2L9"/>
    <dbReference type="GeneID" id="28762803"/>
    <dbReference type="InParanoid" id="A0A177C2L9"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG00880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="99" mass="11061" checksum="E8D1A6A00A984DE6" modified="2016-09-07" version="1">MRSMRSKTSSAHFIALPGCTLGFKGTWDAATSMTWRLLLRIQVAGNRSSEVNEWDRRRDMIMELSIPGLWPIYLVLHACSASQTPGHKIGSTKDQTPSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C2Z2</accession>
    <name>A0A177C2Z2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_280732</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441558">
        <property type="protein sequence ID" value="OAG01252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031617.1">
        <property type="nucleotide sequence ID" value="XM_018185754.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C2Z2"/>
    <dbReference type="GeneID" id="28769240"/>
    <dbReference type="InParanoid" id="A0A177C2Z2"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG01252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="172" mass="19101" checksum="24246A6F2BADC585" modified="2016-09-07" version="1">MYFCSHETSIRVSALSSPETPGSGCTFPRISSTERCAQHGRRLRHRHTLPGCCECRRHLDILLAARPQRALRVRSARRDNMQNGYSRHQGVEKHNLREELAVMHAISSTGLRRVKGLGTTVRCEAASCRARHLNFVSRLTTNGAATPSTLRVSAPSRSAGHQSMGNKHLHTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C3E8</accession>
    <name>A0A177C3E8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NmrA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_194567</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441557">
        <property type="protein sequence ID" value="OAG01429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031794.1">
        <property type="nucleotide sequence ID" value="XM_018185548.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C3E8"/>
    <dbReference type="STRING" id="1460663.A0A177C3E8"/>
    <dbReference type="GeneID" id="28769034"/>
    <dbReference type="InParanoid" id="A0A177C3E8"/>
    <dbReference type="OrthoDB" id="9997102at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051164">
        <property type="entry name" value="NmrA-like_oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748">
        <property type="entry name" value="NITROGEN METABOLITE REPRESSION PROTEIN NMRA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748:SF25">
        <property type="entry name" value="NMRA FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="5"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAG01429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="316" mass="34644" checksum="B56B35326CAEF113" modified="2016-09-07" version="1">MASAKPILITGATGKQGGAVLEQLATHASSSQFVLLAVTRNTTSTSAQKIANRFPNVLLVQGDMNDVPDLFKSAQNTLKSAGKPSKIWGVYSVQISLGPGVTFEGEIEQGKAMIDESVAHGVKHFVYSSVDRGGNAKSFENETPIPHFKSKYQIEHHLLEKAGSKGENMGWTILRPVAFMDNLEPGFKTKVFLAALRDTLQGKPLQWISTEDIGIFAAKAFRDPESWNTRAESLAGDELTLEEMAGCFERVTGSANIATYSFFGSGLMWAVKELNVMITWFATDGYGADIGKLKKEEPQLCGFERWLRERSGWKTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C3G7</accession>
    <name>A0A177C3G7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF7791 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1076655</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441556">
        <property type="protein sequence ID" value="OAG02284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032649.1">
        <property type="nucleotide sequence ID" value="XM_018173725.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C3G7"/>
    <dbReference type="STRING" id="1460663.A0A177C3G7"/>
    <dbReference type="GeneID" id="28757211"/>
    <dbReference type="InParanoid" id="A0A177C3G7"/>
    <dbReference type="OrthoDB" id="443402at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056693">
        <property type="entry name" value="DUF7791"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF5">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25053">
        <property type="entry name" value="DUF7791"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7791" evidence="1">
        <location>
            <begin position="181"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF25053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG02284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="271" mass="31856" checksum="6A76B9DF3E19F5E7" modified="2016-09-07" version="1" fragment="single">VLSSSDRNEIPWSLSELEDAFNRLKTQHEIPVKFYFHIDGLDEFDGDHYKVIDIMEALAQLPNFKICVSSRPWNQFKHTIGQSSADSMQLHLFTRKDIENFARDSILTHRDYQRQNVQRQQYEDLVNSIGQRSEGVFLWVRLVVRSLRDGLLNDDPVSLIRKRLEQLPIDLEQFFRHILESVDSVYSERMARTFLSALAAPEPLEIIHYSFLDEEDPYFGWTLTFEPMDPTTVTKRVSETRWRLNGRYKGLLEPSSDEDSSRVTVDFLHRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C3P8</accession>
    <name>A0A177C3P8_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF2415 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_193106</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441557">
        <property type="protein sequence ID" value="OAG01407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031772.1">
        <property type="nucleotide sequence ID" value="XM_018185539.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C3P8"/>
    <dbReference type="STRING" id="1460663.A0A177C3P8"/>
    <dbReference type="GeneID" id="28769025"/>
    <dbReference type="InParanoid" id="A0A177C3P8"/>
    <dbReference type="OrthoDB" id="418169at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019417">
        <property type="entry name" value="DUF2415"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43991:SF9">
        <property type="entry name" value="DUF2415 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43991">
        <property type="entry name" value="WD REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_8G05640)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10313">
        <property type="entry name" value="DUF2415"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2415" evidence="2">
        <location>
            <begin position="326"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="535"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="554"/>
            <end position="565"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG01407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="701" mass="78080" checksum="23B075FCD3E8EFE6" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2023-06-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C3R2</accession>
    <name>A0A177C3R2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1008024</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441556">
        <property type="protein sequence ID" value="OAG02263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032628.1">
        <property type="nucleotide sequence ID" value="XM_018173346.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C3R2"/>
    <dbReference type="GeneID" id="28756832"/>
    <dbReference type="InParanoid" id="A0A177C3R2"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG02263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="125" mass="13321" checksum="F572053AF6BB5D3F" modified="2016-09-07" version="1">MCAMQCLTGDRCPAATALVADSLCSLDSTHAINRNRKLHVGRHGLLGLCLSTSTCLAIMACGSQAWTPATMGDPAFKAMSDRPGLACQACRQFALAQPHTQLSFFLTSASVLQHQQPYTRCHPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C4D5</accession>
    <name>A0A177C4D5_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">RuvB-like helicase</fullName>
            <ecNumber evidence="15">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CC84DRAFT_1179781</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">DNA helicase participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 15">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the RuvB family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="15"/>
    <dbReference type="EMBL" id="KV441557">
        <property type="protein sequence ID" value="OAG01749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032114.1">
        <property type="nucleotide sequence ID" value="XM_018180432.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C4D5"/>
    <dbReference type="FunCoup" id="A0A177C4D5">
        <property type="interactions" value="1383"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177C4D5"/>
    <dbReference type="GeneID" id="28763918"/>
    <dbReference type="InParanoid" id="A0A177C4D5"/>
    <dbReference type="OrthoDB" id="10060499at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031011">
        <property type="term" value="C:Ino80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097255">
        <property type="term" value="C:R2TP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000812">
        <property type="term" value="C:Swr1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000492">
        <property type="term" value="P:box C/D snoRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002221">
        <property type="entry name" value="RuvB-like 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000010">
        <property type="entry name" value="RuvB-like helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.360:FF:000002">
        <property type="entry name" value="RuvB-like helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.360">
        <property type="entry name" value="RuvB-like helicase, domain II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027238">
        <property type="entry name" value="RuvB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041048">
        <property type="entry name" value="RuvB-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042487">
        <property type="entry name" value="RuvBL1/2_DNA/RNA_bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010339">
        <property type="entry name" value="TIP49_P-loop"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11093">
        <property type="entry name" value="RUVB-RELATED REPTIN AND PONTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06068">
        <property type="entry name" value="TIP49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17856">
        <property type="entry name" value="TIP49_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0010">Activator</keyword>
    <keyword evidence="7 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 15" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4 15" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12 15" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 15" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13 15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 15" id="KW-0804">Transcription</keyword>
    <keyword evidence="9 15" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="16">
        <location>
            <begin position="68"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU363048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="OAG01749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="471" mass="51369" checksum="5FFE8F384C5D693C" modified="2016-09-07" version="1">MALPITTIAESKELRGLNLIAAHSHIRGLGVEPDTLEPKSSSQGLVGQEKARKAAAVILQMAKDGKIAGRAVLIAGPPSTGKTAIAMGMSQSLGADVPFTMLASSEIFSLEMSKTEALTQAFRKSIGVRITEESEVIEGEVVEIQIDRSVTGGNKQGKLTIKTTDMETIYDMGTKMIDAMTKEKVMAGDIISIDKASGKITKLGRSYTRSRDYDAMGIDTKFVQCPEGELQQRREVVHTVSLHEIDVINSRTQGFLALFSGDTGEIRSEVRDQINTKVAEWKEEGKAEIVPGVLFIDEVHMLDIECFSFINRALEDELAPIVIMASNRGNTQIRGTDYRSPHGLPLDFLDRVVIVSTHPYNREEMQQILSIRAQEEEVDVSPDALALLTKIGQETGLRYASNLITTSDLIRTKRQGSEVTVDDVQRSFALFYDPTRSVKYVAESEKRLIGDAGAVSLSVTNGAGADAMDVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C4M8</accession>
    <name>A0A177C4M8_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein AF-9 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">YAF9</name>
        <name evidence="6" type="ORF">CC84DRAFT_1098865</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for an H2A variant leading to transcriptional regulation of selected genes by chromatin remodeling. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histones H4 and H2A. The NuA4 complex is also involved in DNA repair. Yaf9 may also be required for viability in conditions in which the structural integrity of the spindle is compromised.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the SWR1 chromatin-remodeling complex and of the NuA4 histone acetyltransferase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="3">The coiled-coil domain is required for assembly into the NuA4 complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the YAF9 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441556">
        <property type="protein sequence ID" value="OAG02455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032820.1">
        <property type="nucleotide sequence ID" value="XM_018174792.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C4M8"/>
    <dbReference type="FunCoup" id="A0A177C4M8">
        <property type="interactions" value="688"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177C4M8"/>
    <dbReference type="GeneID" id="28758278"/>
    <dbReference type="InParanoid" id="A0A177C4M8"/>
    <dbReference type="OrthoDB" id="16041at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000812">
        <property type="term" value="C:Swr1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1970">
        <property type="entry name" value="YEATS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038704">
        <property type="entry name" value="YEAST_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005033">
        <property type="entry name" value="YEATS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055129">
        <property type="entry name" value="YEATS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23195">
        <property type="entry name" value="YEATS DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03366">
        <property type="entry name" value="YEATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51037">
        <property type="entry name" value="YEATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0010">Activator</keyword>
    <keyword evidence="3" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1 2 3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="YEATS" evidence="5">
        <location>
            <begin position="7"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="175"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="234"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU367117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAG02455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="277" mass="31368" checksum="65A755927BAA7D7D" modified="2016-09-07" version="1">MPAPAANKRNKRVSRNIIIGSEAWALPPVGHPDRPKGVPDDHTKRWTVYVRQPDGDPSLTTWLNKVQFKIFNTYENPLRTCDNPPFQVTETGWGGFTIDIRLHFQPISGEKAQYRQHFLQLEKYGDEKLQAEQERTGCVRSEYLEVVQFNEPTEALYEALTADDQWSYLALGAKGGKKTSSMSTGPNGRPKRGFPNGERSAQLPEKGGDDIPFSQEQEAELMNQLKAKMQMVEKALEEENKKREDTESKLKSLRAELGHEAAQQAAQQASGDRSRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C5F9</accession>
    <name>A0A177C5F9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1207541</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG02666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033031.1">
        <property type="nucleotide sequence ID" value="XM_018182107.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C5F9"/>
    <dbReference type="GeneID" id="28765593"/>
    <dbReference type="InParanoid" id="A0A177C5F9"/>
    <dbReference type="OrthoDB" id="5342507at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="54"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="92"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="126"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="188"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG02666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="234" mass="26156" checksum="BB50D1C9B1B53291" modified="2016-09-07" version="1">MSTTRDSYDARRQPYDGPADPRDKSQETGLLTRWVPEKLKHGGFYRWFLRFTRVLQFLSSIISLGVFSSRLYKVYRLVNSIRTRRGVNGAYGAVEGILAAAVLYTLITTLLGCIKKSANPGGKALRWIWVLMDVLFVGAFIAVSVLTRPSGGLAGVANCYNPQRLSGNNGGDITGETASQDDTCNLPWGTFILAIISTILHAITAAFHEVKDQRRQNRLHREKVVQRQYENDTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C5K2</accession>
    <name>A0A177C5K2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SET domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1167284</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441556">
        <property type="protein sequence ID" value="OAG02162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032527.1">
        <property type="nucleotide sequence ID" value="XM_018179144.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C5K2"/>
    <dbReference type="FunCoup" id="A0A177C5K2">
        <property type="interactions" value="68"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177C5K2"/>
    <dbReference type="GeneID" id="28762630"/>
    <dbReference type="InParanoid" id="A0A177C5K2"/>
    <dbReference type="OrthoDB" id="1028014at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20071">
        <property type="entry name" value="SET_SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050869">
        <property type="entry name" value="H3K4_H4K5_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12197">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12197:SF294">
        <property type="entry name" value="POTENTIAL PROTEIN LYSINE METHYLTRANSFERASE SET6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SET" evidence="2">
        <location>
            <begin position="17"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG02162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="364" mass="40919" checksum="0B03D0A42531C5FE" modified="2016-09-07" version="1">MEGEEQPPLPPGAPTSHLFEVRHTPHSGRAVFATQDIPADTLVFLGDDLTVDVVLREYRREVCGECFGYDRGRDLCVRDNTVGFAFCSEECRGQWRNRVGELGVETWTAVEKLVKGRSKEDADMVDVGLPRPKTKEIRIAWEGTADQAALIRIARSSVSSPDSSGENKGETGTVKPTKQHRKAVQKALMQPVSPDVLTFCVNGVLWKYNNPAKWDHILALAKDNTPYHNYDDLRAFTRSYLHMLAVCPSALLEHVTPETLFLLSSRDSHNSFGIRSLEDDGSEFFGYGCWPSASYFNHSCGPNVEKKRVGRVWHFRTGTKIKVGEELCITYLSGEERKLSRNKRMKTLKGNWGFECGCERCEAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C6H5</accession>
    <name>A0A177C6H5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Pectin lyase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CC84DRAFT_1166883</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Pectinolytic enzyme involved in the degradation of xylogalacturonan (xga), a galacturonan backbone heavily substituted with xylose, and which is one important component of the hairy regions of pectin. Activity requires a galacturonic acid backbone substituted with xylose.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the glycosyl hydrolase 28 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG03135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033500.1">
        <property type="nucleotide sequence ID" value="XM_018179073.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C6H5"/>
    <dbReference type="STRING" id="1460663.A0A177C6H5"/>
    <dbReference type="GeneID" id="28762559"/>
    <dbReference type="InParanoid" id="A0A177C6H5"/>
    <dbReference type="OrthoDB" id="187139at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004650">
        <property type="term" value="F:polygalacturonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000743">
        <property type="entry name" value="Glyco_hydro_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31736">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31736:SF9">
        <property type="entry name" value="ENDO-XYLOGALACTURONAN HYDROLASE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00295">
        <property type="entry name" value="Glyco_hydro_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="10" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 13" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 14" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008057814" evidence="14">
        <location>
            <begin position="21"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00037278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OAG03135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="397" mass="42719" checksum="DBEC4B293F151FF6" modified="2016-09-07" version="1">MRSFSLCSSALALFALPALAGPSADNTCTPLANGFAAIDDSPAINAALVECGAGGTIVLPADQAYSIFTPLDFSLCRHCDVQIEGTLILAAEQLPYYGTLPYYANGATRSVFTIANATGVRIRSVTGSGVVDGNAVSWYQRTKWSPKTGGYPFVHVTNGSTDVSVENLHFKNIQDRVFRLQGGSSNLRFEDVRITAEGINPNYASFDNFAFEMGKVENVSIANVDIDFGAQTGSDRPVGTCVSFDHGTDGVAVANVTCRRAFMGAAIQFDTISAFAPSAANATATVSNILVSNFTFAGAHATGVESWFNLSKKVIRNAVWEWVTVEGGTPAEFDPCYASMRDTQYYPRCLQYATYDAEVVFRHYRGKVGSPPTDPRWGEVNGLMDVRPVFEDWVADA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C6N4</accession>
    <name>A0A177C6N4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Beta-lactamase/transpeptidase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_1126751</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S12 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441556">
        <property type="protein sequence ID" value="OAG02438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032803.1">
        <property type="nucleotide sequence ID" value="XM_018175751.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C6N4"/>
    <dbReference type="STRING" id="1460663.A0A177C6N4"/>
    <dbReference type="GeneID" id="28759237"/>
    <dbReference type="InParanoid" id="A0A177C6N4"/>
    <dbReference type="OrthoDB" id="5946976at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="entry name" value="DD-peptidase/beta-lactamase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050491">
        <property type="entry name" value="AmpC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049511">
        <property type="entry name" value="PGH-like_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46825:SF9">
        <property type="entry name" value="BETA-LACTAMASE-RELATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46825">
        <property type="entry name" value="D-ALANYL-D-ALANINE-CARBOXYPEPTIDASE/ENDOPEPTIDASE AMPH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17660">
        <property type="entry name" value="BTRD1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="beta-lactamase/transpeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008057777" evidence="2">
        <location>
            <begin position="20"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-lactamase-related" evidence="3">
        <location>
            <begin position="313"/>
            <end position="588"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAG02438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="641" mass="70464" checksum="E90A477EB26A5E5B" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2023-06-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C7A1</accession>
    <name>A0A177C7A1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_939371</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG03001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033366.1">
        <property type="nucleotide sequence ID" value="XM_018187934.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C7A1"/>
    <dbReference type="GeneID" id="28771420"/>
    <dbReference type="InParanoid" id="A0A177C7A1"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG03001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="192" mass="20909" checksum="F2166E2B25206305" modified="2016-09-07" version="1">MRAISNFDHLLLEDSSIPEVSHASRKTLAPALNAIAVGLDLGRNASPILCSCLVFLKMTAVGEDVVPCLSDICRTCGIPWTYAFVSSAFLSTSSTIGRVAACAKIHATIFTISFTALVNAWSPTMLIPPLLHLERSHPRISQDLGFLYSARHMPSTSSCIVDWASNFNQIAWMRILHNMSTDECVVAPPYSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C7V2</accession>
    <name>A0A177C7V2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">PalH-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_1166585</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the palH/RIM21 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG02780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033145.1">
        <property type="nucleotide sequence ID" value="XM_018178998.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C7V2"/>
    <dbReference type="STRING" id="1460663.A0A177C7V2"/>
    <dbReference type="GeneID" id="28762484"/>
    <dbReference type="InParanoid" id="A0A177C7V2"/>
    <dbReference type="OrthoDB" id="5393256at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071467">
        <property type="term" value="P:cellular response to pH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014844">
        <property type="entry name" value="PalH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35779">
        <property type="entry name" value="PH-RESPONSE REGULATOR PROTEIN PALH/RIM21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35779:SF1">
        <property type="entry name" value="PH-RESPONSE REGULATOR PROTEIN PALH_RIM21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08733">
        <property type="entry name" value="PalH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="228"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="268"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="302"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="384"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="521"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="622"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="55"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="400"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="462"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="485"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="672"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="738"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="761"/>
            <end position="773"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAG02780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="773" mass="84757" checksum="265B51DA56EE5290" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C8F9</accession>
    <name>A0A177C8F9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">CAP20-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_862878</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG03686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034051.1">
        <property type="nucleotide sequence ID" value="XM_018187682.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C8F9"/>
    <dbReference type="GeneID" id="28771168"/>
    <dbReference type="InParanoid" id="A0A177C8F9"/>
    <dbReference type="OrthoDB" id="376826at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17316">
        <property type="entry name" value="Perilipin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG03686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="192" mass="21445" checksum="E91EAF43159D5651" modified="2016-09-07" version="1">MPHAEKDTVNGEMTTRLTNGEKPQSKVLSHLQTYPVVNDGLEFYKSHPYGAKSLNLVHKTYNSFVAPLHPYLQTPYSYLSPYLSRADELGDSGLSKVDTRFPIVKEDTSKLKQTVSEYVGLPFALAGKGRAYVVGTWQDEYSKTRGDGVVKSVKALISTELKIGLDGYTLLVEYWQKGHKEVNKKVNEVSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C8G2</accession>
    <name>A0A177C8G2_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">geranylgeranyl diphosphate synthase</fullName>
            <ecNumber evidence="1">2.5.1.29</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CC84DRAFT_1098077</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.29" evidence="1"/>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG02990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033355.1">
        <property type="nucleotide sequence ID" value="XM_018174751.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C8G2"/>
    <dbReference type="FunCoup" id="A0A177C8G2">
        <property type="interactions" value="458"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177C8G2"/>
    <dbReference type="GeneID" id="28758237"/>
    <dbReference type="InParanoid" id="A0A177C8G2"/>
    <dbReference type="OrthoDB" id="6921389at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004311">
        <property type="term" value="F:geranylgeranyl diphosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046165">
        <property type="term" value="P:alcohol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00685">
        <property type="entry name" value="Trans_IPPS_HT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12001">
        <property type="entry name" value="GERANYLGERANYL PYROPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12001:SF44">
        <property type="entry name" value="GERANYLGERANYL PYROPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00723">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="66"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="103"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAG02990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="431" mass="47784" checksum="4BF43EC4F60CA56A" modified="2016-09-07" version="1">MPSSGPAHASAPTADFQSPFQSPNAIPPRTSSHGIANGVKHRSSVLRPLSEIDWISQSKKSKLLHENQTPNQDQHQLPARPVDTHNTMGGEDEKPAAQQAPHPLAPPQPPLEPSRDIGHDLIYGPRRGWSEENERILLGPYDYLVGHPGKDIRSQCIAAFNKWLKVPAERLEVITRVVGMLHTASLLVDDVEDSSVLRRGIPVANSIFGVAQTINSANYVYFLALSDLLALQNPHLIQIYSQELLNLHRGQGMELHWRDSLTCPSEPAYLEMVDNKTGGLFRLAIKLMQAESTLTTEIDCAPLVSTIGLLFQILDDHLNLSTTSEYQSLKGMCEDLTEGKFSFPVIHAIHADPSNRVIYNILKQKTEDDEVKRYAVRYLEQKGSFEYSKGVIDGLRGKAEGLIAEIEAKVGEEAREGAEGLRRLLARLVVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C8N5</accession>
    <name>A0A177C8N5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CC84DRAFT_960161</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG03138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033503.1">
        <property type="nucleotide sequence ID" value="XM_018187958.1"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177C8N5"/>
    <dbReference type="GeneID" id="28771444"/>
    <dbReference type="InParanoid" id="A0A177C8N5"/>
    <dbReference type="OrthoDB" id="5389400at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056125">
        <property type="entry name" value="DUF7708"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF14">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24809">
        <property type="entry name" value="DUF7708"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="DUF7708" evidence="3">
        <location>
            <begin position="74"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="4">
        <location>
            <begin position="303"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="227"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAG03138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="1406" mass="159874" checksum="1ED90226F0A79356" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C8X8</accession>
    <name>A0A177C8X8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Actin-like ATPase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CC84DRAFT_1124037</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG04204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034569.1">
        <property type="nucleotide sequence ID" value="XM_018175671.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C8X8"/>
    <dbReference type="FunCoup" id="A0A177C8X8">
        <property type="interactions" value="184"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177C8X8"/>
    <dbReference type="GeneID" id="28759157"/>
    <dbReference type="InParanoid" id="A0A177C8X8"/>
    <dbReference type="OrthoDB" id="10262720at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034663">
        <property type="term" value="C:endoplasmic reticulum chaperone complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030968">
        <property type="term" value="P:endoplasmic reticulum unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10230">
        <property type="entry name" value="ASKHA_NBD_HSP70_HYOU1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.10:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000039">
        <property type="entry name" value="Hsp70 family chaperone Lhs1/Orp150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.30:FF:000004">
        <property type="entry name" value="hypoxia up-regulated protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45639">
        <property type="entry name" value="HSC70CB, ISOFORM G-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45639:SF3">
        <property type="entry name" value="HYPOXIA UP-REGULATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0143">Chaperone</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008057847" evidence="10">
        <location>
            <begin position="31"/>
            <end position="1048"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="595"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="825"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="929"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1022"/>
            <end position="1048"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="746"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="595"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="611"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="629"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="825"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="848"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="934"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="968"/>
            <end position="980"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OAG04204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="1048" mass="113809" checksum="BFB67C4B45B322C8" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C987</accession>
    <name>A0A177C987_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 15">Amino-acid acetyltransferase, mitochondrial</fullName>
            <ecNumber evidence="5 15">2.3.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12 15">Glutamate N-acetyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13 15">N-acetylglutamate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CC84DRAFT_895055</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 15">N-acetylglutamate synthase involved in arginine biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>L-glutamate + acetyl-CoA = N-acetyl-L-glutamate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24292"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:44337"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.1.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 15">Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 1/4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 15">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the acetyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.1" evidence="5 15"/>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG04213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034578.1">
        <property type="nucleotide sequence ID" value="XM_018187814.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C987"/>
    <dbReference type="STRING" id="1460663.A0A177C987"/>
    <dbReference type="GeneID" id="28771300"/>
    <dbReference type="InParanoid" id="A0A177C987"/>
    <dbReference type="OrthoDB" id="5585968at2759"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00106"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004042">
        <property type="term" value="F:L-glutamate N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:L-arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006592">
        <property type="term" value="P:ornithine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000049">
        <property type="entry name" value="Amino-acid acetyltransferase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="entry name" value="Acetylglutamate kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011190">
        <property type="entry name" value="GlcNAc_Synth_fun"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006855">
        <property type="entry name" value="Vertebrate-like_GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23342:SF4">
        <property type="entry name" value="AMINO-ACID ACETYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23342">
        <property type="entry name" value="N-ACETYLGLUTAMATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04768">
        <property type="entry name" value="NAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007892">
        <property type="entry name" value="NAGS_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51731">
        <property type="entry name" value="GNAT_NAGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 15" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7 15" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10 15" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="17">
        <location>
            <begin position="547"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="26"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="86"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="319"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="45"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="88"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00033251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRNR" id="PIRNR007892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="OAG04213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="736" mass="80600" checksum="E1D027355717BFB4" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C9R6</accession>
    <name>A0A177C9R6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CC84DRAFT_848082</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG03497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033862.1">
        <property type="nucleotide sequence ID" value="XM_018187626.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C9R6"/>
    <dbReference type="STRING" id="1460663.A0A177C9R6"/>
    <dbReference type="GeneID" id="28771112"/>
    <dbReference type="InParanoid" id="A0A177C9R6"/>
    <dbReference type="OrthoDB" id="545910at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006307">
        <property type="term" value="P:DNA alkylation repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14279">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.590:FF:000010">
        <property type="entry name" value="GRF zinc finger domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.590">
        <property type="entry name" value="Alpha-ketoglutarate-dependent dioxygenase AlkB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027450">
        <property type="entry name" value="AlkB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037151">
        <property type="entry name" value="AlkB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032854">
        <property type="entry name" value="ALKBH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010666">
        <property type="entry name" value="Znf_GRF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31212">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE ALKB HOMOLOG 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31212:SF4">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE ALKB HOMOLOG 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13532">
        <property type="entry name" value="2OG-FeII_Oxy_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06839">
        <property type="entry name" value="Zn_ribbon_GRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51999">
        <property type="entry name" value="ZF_GRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="5">
        <location>
            <begin position="244"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="domain" description="GRF-type" evidence="6">
        <location>
            <begin position="373"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAG03497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="436" mass="49614" checksum="2349B44C39DC1E98" modified="2016-09-07" version="1">MDAFVSRKRRRVDTVHPVVQVELAADRPEEESTDFKLAMLASLHPSIEEGTLLEALLASEGSVEHASEALSANPTPKKRPASSIGYQSSLSSYRVSLNRTGATKKPLVKKGKTLYLYAPEDIEAHTPCSIIHNFLPPEQADALTRELVAESSSYNNIEFKLFDRVVQSPHTFCFYVNSLAEAEEQKTEYTYDGRKVDDVRQSTPEMLRACPQVEDAVNQEIQRRIRDSYPDGKKLKYQTPKPWKANTAFVNCYDGPKECVGYHSDQLTYLGPRAVIGSLSLGVAREFRVRRIYAEDDQHRKEDGSLADAQGQISIHLPHNSLLVMHAEMQEEWKHSITPAQAIDPHPLAKNKRLNITYRYYKENLHPKYTPKCKCGVPTVLRCVTRQKENRGRYMWMCHVSYVPGKEGCSFFQWAEFDEDGEPPWTIKSSCKNQQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CAF3</accession>
    <name>A0A177CAF3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1219329</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG04111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034476.1">
        <property type="nucleotide sequence ID" value="XM_018183072.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CAF3"/>
    <dbReference type="GeneID" id="28766558"/>
    <dbReference type="InParanoid" id="A0A177CAF3"/>
    <dbReference type="OrthoDB" id="3776815at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008058011" evidence="1">
        <location>
            <begin position="17"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG04111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="276" mass="28746" checksum="B4A43F0E113076F9" modified="2016-09-07" version="1">MSPILSTLLFAAAATAQVTTSIWMPSPYQEDTHIGFYASVVGVSEGKTTLALSFDNKTDLATAGYIVEDEPNTMTFYGSSRFESVTTTTDVSDGLALTMGYGCQETSARGGVSVGAMCRFASEGPAVYSSVCEKYSDYTDVYTTTKEFAYGDDYTVTETTTIDYRTRVPSYCKSGSTLPESIIANTYMIEQEEIATYQVVITAGADKLSATAGATPSSSGPAPTGTGAFTLHKGQNVVPTETGSALPVQETGAAGALLALHPALAGLGAAAMAFLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CB60</accession>
    <name>A0A177CB60_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1165188</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG04815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035180.1">
        <property type="nucleotide sequence ID" value="XM_018178662.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CB60"/>
    <dbReference type="GeneID" id="28762148"/>
    <dbReference type="InParanoid" id="A0A177CB60"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG04815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="193" mass="21365" checksum="549673DB22266408" modified="2016-09-07" version="1">MERKRCVINDDAGLAAEKFEVRDRACIGEMVRASAVSTRGPDTIRTIGPQYVASKLLVLVLSSSDMWMSSFRHVTDFNVEDLTATGSLLATCDGYALFWNKLRYLLCFHRTEVNTFNPPEVAPGAIVPYVSSKFDSFGPPVMSSCLAEEASPMYQQEPQSCTASEFAATLVRATEPHRHCRYQIIPTSQLGNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CBS2</accession>
    <name>A0A177CBS2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">FAD-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CC84DRAFT_1261139</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG04150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034515.1">
        <property type="nucleotide sequence ID" value="XM_018185039.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CBS2"/>
    <dbReference type="STRING" id="1460663.A0A177CBS2"/>
    <dbReference type="GeneID" id="28768525"/>
    <dbReference type="InParanoid" id="A0A177CBS2"/>
    <dbReference type="OrthoDB" id="2151789at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF54">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008057992" evidence="5">
        <location>
            <begin position="17"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="6">
        <location>
            <begin position="60"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAG04150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="487" mass="53919" checksum="B5DD5F062E8628D6" modified="2016-09-07" version="1">MCNARLALALLATCAADSFSNYGEIDQACTMLESELPGCVYYPNSTAFEQSVASYIYAGSRLRPNCILGPKQAEDVQKAVQVLTQYPSVEFAVRSGGHNINKGFANTDLGVTIDLAALDDVEVSSDKSYVSIGVGARWGKVYATVEQQGLSGISYYSPERGWACDSVKSFDIVLANGSLINANAQSNADLFRALKGGSNNFGIVTHFELDVFEQGPLTGGSMDYGNVTGEQVVNTITSFKQPQMFDKHAMLIAIFSYQAHKHLFSHSATFFHTRPEKYFGSTLEAFTRVEPQTNVTLPVMNNTAGFFAGLSGSYDPSYAPNNFMHWTCLQFRVTKTILHKINGLYREHSLRLANVPAYRSANLTVFLVLQSVPATRPGNSLGFEPDSHPEKDQLNLLIMYQYDEGRMEVALQREINRLTKEVEDIAREERALSQFIYLNYAGSDQKVLEGYGKKSVEKLKRVAAEYDPDGVFQKQVRGGFKLSDVHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CC99</accession>
    <name>A0A177CC99_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">p-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CC84DRAFT_1094594</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family. BCS1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG04388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034753.1">
        <property type="nucleotide sequence ID" value="XM_018174571.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CC99"/>
    <dbReference type="STRING" id="1460663.A0A177CC99"/>
    <dbReference type="GeneID" id="28758057"/>
    <dbReference type="InParanoid" id="A0A177CC99"/>
    <dbReference type="OrthoDB" id="10251412at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050747">
        <property type="entry name" value="Mitochondrial_chaperone_BCS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23070">
        <property type="entry name" value="BCS1 AAA-TYPE ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="4">
        <location>
            <begin position="8"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="77"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAG04388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="173" mass="18589" checksum="A437F6F80AD39CA3" modified="2016-09-07" version="1" fragment="single">YSASGIPYKRGILLQGPPGTGKSSISLALAGHIRASLYNITIGEVRNGGHLVELFLSARHGSVVLLEDIDSAGIGREKVSISEDSPNASKNGEEKPNSDTELAEDGVVLIMTTNEPENLDKALIRPGRIDKQIHVGHASRAVAGNIFTRFYSDINNERDVSDYISEMAIEFVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CCI8</accession>
    <name>A0A177CCI8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acyl-CoA N-acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1218427</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG05036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035401.1">
        <property type="nucleotide sequence ID" value="XM_018182995.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CCI8"/>
    <dbReference type="STRING" id="1460663.A0A177CCI8"/>
    <dbReference type="GeneID" id="28766481"/>
    <dbReference type="InParanoid" id="A0A177CCI8"/>
    <dbReference type="OrthoDB" id="2129362at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43072:SF8">
        <property type="entry name" value="ACYLTRANSFERASE FABY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43072">
        <property type="entry name" value="N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="15"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG05036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="200" mass="22142" checksum="075D16BC9775B040" modified="2016-09-07" version="1">MTGLAKEEAATKPAYLVRPAVAADISSISTIAAWYVRNTVLTFRYNPATEEELLQEFYSIGQERLPYLIAADKSTGTILGYCYAARFRPAKLGYKPTVELSLYCDPDHRSKGIGSLLLKEVLQALRNWEPGTDSCISSDLDKVGVKTVLATMAVDETGPGGGLTLQRFYERAGFEQAGRLKHVGYKFGRWIDSIYMQLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CCJ9</accession>
    <name>A0A177CCJ9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Kinase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CC84DRAFT_795169</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG04529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034894.1">
        <property type="nucleotide sequence ID" value="XM_018187436.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CCJ9"/>
    <dbReference type="FunCoup" id="A0A177CCJ9">
        <property type="interactions" value="101"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CCJ9"/>
    <dbReference type="GeneID" id="28770922"/>
    <dbReference type="InParanoid" id="A0A177CCJ9"/>
    <dbReference type="OrthoDB" id="410920at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000640">
        <property type="entry name" value="Serine/threonine-protein kinase PRR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF110">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="4">
        <location>
            <begin position="344"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="164"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="298"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="30"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="179"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="235"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAG04529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="669" mass="72832" checksum="9AA7EEEBD1B597DF" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CE01</accession>
    <name>A0A177CE01_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_818697</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG05029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035394.1">
        <property type="nucleotide sequence ID" value="XM_018187528.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CE01"/>
    <dbReference type="GeneID" id="28771014"/>
    <dbReference type="InParanoid" id="A0A177CE01"/>
    <dbReference type="OrthoDB" id="10390201at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="232"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG05029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="274" mass="30518" checksum="5E19B507E8FC93E1" modified="2016-09-07" version="1">MSHSYTEPAFKGKKMYPKQNTQKSTQLTNRPMANIESNSPPSTPMFEVAARTCLLRPKPRPLPITVNTTWFEDNVNEHSLFKTRRKGAKDVQKTLEASYARPASRGSTTRQALFGLPETAELVEQFHEFQTQEHDDPPPYYEAVELILSPTELSARARTFSDVMKHGNKLEENGILKFASELDEASDTQRTFSTFLRRSGVASRQSAAGILGLPGYAYMPHKNGINLHSKETAAATTRGTDDPQTEAGLHERVAVDADVDADVEAQTKARSHNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CEI2</accession>
    <name>A0A177CEI2_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Up-regulated during septation protein 1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_1094636</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG05209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035574.1">
        <property type="nucleotide sequence ID" value="XM_018174572.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CEI2"/>
    <dbReference type="STRING" id="1460663.A0A177CEI2"/>
    <dbReference type="GeneID" id="28758058"/>
    <dbReference type="InParanoid" id="A0A177CEI2"/>
    <dbReference type="OrthoDB" id="5429395at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029191">
        <property type="entry name" value="Uds1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15456">
        <property type="entry name" value="Uds1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Up-regulated during septation protein 1" evidence="3">
        <location>
            <begin position="406"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="41"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="195"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="241"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="528"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="485"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="42"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="265"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="324"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="340"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="359"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF15456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAG05209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="584" mass="64169" checksum="87818CE3F5F71707" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CEM7</accession>
    <name>A0A177CEM7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tat pathway signal sequence</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1197077</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ustYa family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG05190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035555.1">
        <property type="nucleotide sequence ID" value="XM_018181501.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CEM7"/>
    <dbReference type="STRING" id="1460663.A0A177CEM7"/>
    <dbReference type="GeneID" id="28764987"/>
    <dbReference type="InParanoid" id="A0A177CEM7"/>
    <dbReference type="OrthoDB" id="3687641at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021765">
        <property type="entry name" value="UstYa-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365:SF14">
        <property type="entry name" value="TAT PATHWAY SIGNAL SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365">
        <property type="entry name" value="YALI0B05434P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11807">
        <property type="entry name" value="UstYa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00035112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG05190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="224" mass="25661" checksum="2CDD9F777AC17EC0" modified="2016-09-07" version="1">MRITLSSYTPLLDKLNFTFINKKINGSLFNDPWSVYKAEPSKEVDAAWEEISKIRALVVEADEIRKMGKDPEFAVQVPLEWGYGSTKYFAELDSQHLLHCLNTVRKYSHYSHYFYPKWGDESNMPALAVAHRSHCIGILLDALTCQPSLNLLHFNWMETQENPFPDFGINRKCVDHSAVLEWQDRVGIREDLVVDAKIERPEDAKVIPALPQLLELGNGEGLIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CET8</accession>
    <name>A0A177CET8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CC84DRAFT_1195888</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG05422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035787.1">
        <property type="nucleotide sequence ID" value="XM_018181424.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CET8"/>
    <dbReference type="STRING" id="1460663.A0A177CET8"/>
    <dbReference type="GeneID" id="28764910"/>
    <dbReference type="InParanoid" id="A0A177CET8"/>
    <dbReference type="OrthoDB" id="5376138at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000088">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF3">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="129"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="165"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="272"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="303"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="349"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="377"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="408"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="448"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="490"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAG05422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="512" mass="57536" checksum="06167C657AD48C57" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CF21</accession>
    <name>A0A177CF21_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1091469</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG06205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036570.1">
        <property type="nucleotide sequence ID" value="XM_018174402.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CF21"/>
    <dbReference type="STRING" id="1460663.A0A177CF21"/>
    <dbReference type="GeneID" id="28757888"/>
    <dbReference type="InParanoid" id="A0A177CF21"/>
    <dbReference type="OrthoDB" id="2157530at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF82">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="46"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG06205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="131" mass="15380" checksum="2B2A33043EF506EB" modified="2016-09-07" version="1" fragment="single">MTQHSYPYEPLKTKDSFRVLELLPGILDDPLQCRIRETIWSPDTKYEALSYVWGPPIFPMSMEETSSVSILWITENLFHALRILRYKHMRRTLWVDAICINQSDNVEKGHQVALMGNIYRKAQSVVVWLGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CF40</accession>
    <name>A0A177CF40_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Asp-tRNA Asn/Glu-tRNA Gln amidotransferas-like protein subunit A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1163986</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG05449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035814.1">
        <property type="nucleotide sequence ID" value="XM_018178383.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CF40"/>
    <dbReference type="STRING" id="1460663.A0A177CF40"/>
    <dbReference type="GeneID" id="28761869"/>
    <dbReference type="InParanoid" id="A0A177CF40"/>
    <dbReference type="OrthoDB" id="6428749at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42678">
        <property type="entry name" value="AMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42678:SF2">
        <property type="entry name" value="AMIDASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G14410)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="2">
        <location>
            <begin position="27"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG05449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="442" mass="47736" checksum="EF5269074A806C6C" modified="2016-09-07" version="1">MEPFRLTASQAQAKFKDGSLTVEQYAQSLLDRVAARDSTVNAWAYLNPELVLERARELDAIPPEKRSPLHGVAIGVKDVILTKDMPTQYNSPIYVDDAPKIDAASIQTLRANGALIFGKTTTTEFAATVVGPSHKGPKTTNAHNSKRTPGGSSSGSGAAVGDLQVPIGLGTQTVGSTIRPGSFNGIYAMKPTWNSISREGQKLYSLILDTLGLYARSVEDLKLLLDAFQLVDDEPEEPFTLKGAKLALLTLPTPEWPEPGPGTAAALKKGTELLRAHGAEVEEITLPDEFRSMYKYHLQVLSGDGRVAFLADYYGAKDKMHGSLIDHVENKDKHTRQDQLKAFDELAAMRPKIDAFASKYSAIVAPSVLDEAPVGLENTGSAAFCGPWTAMHTPVVNIPGFKGENGLPIGLSVVAGRYRDQYLLRVCTEIGKVFEGEGGWSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CG46</accession>
    <name>A0A177CG46_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">GroES-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CC84DRAFT_1092035</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG05808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036173.1">
        <property type="nucleotide sequence ID" value="XM_018174427.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CG46"/>
    <dbReference type="STRING" id="1460663.A0A177CG46"/>
    <dbReference type="GeneID" id="28757913"/>
    <dbReference type="InParanoid" id="A0A177CG46"/>
    <dbReference type="OrthoDB" id="1879366at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08297">
        <property type="entry name" value="CAD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940:SF8">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="6">
        <location>
            <begin position="25"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAG05808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="363" mass="39716" checksum="7E76DA0CD367FFC7" modified="2016-09-07" version="1" fragment="single">DFHAWMMTSPHMRAAQITEFNKPYQLNLQPVPQCGDNDLLVEVHAAGFCHSDLQVWEGNFKAKLPMIPSHEPAGKIVQIGARAKGSWKVGDRVGVLNFKNACKECVGCRQYNRKKGCTDPRFCEKREMAGFKHDGAFAEYMIADPATTVHLPENISFEQGAPLMCAGATVWGALQKLKPEVQPGETVAIVGIGGLGQLGIQFAKAMGFETVAIDNRLEGRRLATEVSSNLRPDLIVDSSAPDASDKIMDFTAGEGLAGIVVCTDSVPANTWSLRQLGNGGVMVPVGLPQDRWQFDTEPIVFRELTIRGVYVAGREQVEEMLKVVADHKILSHVTSVSFDEIPNLVAKYTDPAMKGRLVVQIKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CGC9</accession>
    <name>A0A177CGC9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1120327</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG06406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036771.1">
        <property type="nucleotide sequence ID" value="XM_018175575.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CGC9"/>
    <dbReference type="STRING" id="1460663.A0A177CGC9"/>
    <dbReference type="GeneID" id="28759061"/>
    <dbReference type="InParanoid" id="A0A177CGC9"/>
    <dbReference type="OrthoDB" id="3468019at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39401">
        <property type="entry name" value="SNOAL-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39401:SF1">
        <property type="entry name" value="SNOAL-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG06406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="140" mass="15806" checksum="3AE4E88B092D131A" modified="2016-09-07" version="1">MSSYTSEYPSIPFEPAFKKFFEDFYATSDIPDAHDAYVQFFTKDAALIMASKKAQGSEEILALRKGLWDKVASRVHNPIKIFPYGPNSNEVMLHGTVKYGLKAGGESSLDWAAYARLVKEEEKVKMEFYQVYLDTGAQAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2023-06-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CGW4</accession>
    <name>A0A177CGW4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_622256</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG06814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037179.1">
        <property type="nucleotide sequence ID" value="XM_018186919.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CGW4"/>
    <dbReference type="GeneID" id="28770405"/>
    <dbReference type="InParanoid" id="A0A177CGW4"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG06814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="230" mass="25536" checksum="5F49D46E54A7B95A" modified="2016-09-07" version="1">MTLVGRHPTRRQSAPESRRTWECWRPAWRHIRELRIALPRAKQSMLSCLGGLLGIPASRAAWPTPPGSGPGKLEARRASFNGAPSGAEQEYLVCLQRRRGLPTKRYMLRFHSKHVRRDPNLDRAVSMARRSVSKQPLRCYSALSKATRRRGSALCAFDAVIDRLAQSGACYSVPLQSPYAVAPVQFSPPAWPSRMACLPRTPEARCRSALQCSALPQMGPSPVRGRQASV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CHV5</accession>
    <name>A0A177CHV5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">WD40 repeat-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_1146495</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG06400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036765.1">
        <property type="nucleotide sequence ID" value="XM_018176554.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CHV5"/>
    <dbReference type="FunCoup" id="A0A177CHV5">
        <property type="interactions" value="939"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CHV5"/>
    <dbReference type="GeneID" id="28760040"/>
    <dbReference type="InParanoid" id="A0A177CHV5"/>
    <dbReference type="OrthoDB" id="431715at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045943">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018983">
        <property type="entry name" value="U3_snoRNA-assocProt_15_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19924:SF26">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 15 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19924">
        <property type="entry name" value="UTP15 U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 15 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09384">
        <property type="entry name" value="UTP15_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="3 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="132"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="175"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="259"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="U3 small nucleolar RNA-associated protein 15 C-terminal" evidence="7">
        <location>
            <begin position="383"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF09384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAG06400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="546" mass="59917" checksum="220E827E325C108B" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CIP1</accession>
    <name>A0A177CIP1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CC84DRAFT_1087787</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG06719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037084.1">
        <property type="nucleotide sequence ID" value="XM_018174217.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CIP1"/>
    <dbReference type="FunCoup" id="A0A177CIP1">
        <property type="interactions" value="800"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CIP1"/>
    <dbReference type="GeneID" id="28757703"/>
    <dbReference type="InParanoid" id="A0A177CIP1"/>
    <dbReference type="OrthoDB" id="340500at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071034">
        <property type="term" value="P:CUT catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000467">
        <property type="term" value="P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071051">
        <property type="term" value="P:poly(A)-dependent snoRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000127">
        <property type="entry name" value="Exosome complex component RRP40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000073">
        <property type="entry name" value="Putative Exosome complex component RRP40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026699">
        <property type="entry name" value="Exosome_RNA_bind1/RRP40/RRP4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041054">
        <property type="entry name" value="Rrp40_N_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21321:SF1">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21321">
        <property type="entry name" value="PNAS-3 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15985">
        <property type="entry name" value="KH_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18311">
        <property type="entry name" value="Rrp40_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21262">
        <property type="entry name" value="RRP40_S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0271">Exosome</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Exosome complex exonuclease Rrp40 N-terminal" evidence="6">
        <location>
            <begin position="24"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="5">
        <location>
            <begin position="153"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF15985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF18311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAG06719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="237" mass="24638" checksum="76AF49A8FB02E57E" modified="2016-09-07" version="1">MVVLPGDIVPQDGLPTPTGKKKHLTLGPGLRHIPPSTVSSTIAGGLVTDPKKVAAWIESNSGRYLPTTGDLVIATVQTSTAEAFNCTLTPHTPYATLPHLAFEGATKKTRPQLAPNSLVYARVASATKDFAPELTCVDPSTGKSEGLGPLKSGMVFQISLGMARRLLAGKKGGVILLEALGEKVGFEIAVGRNGVVVVDAGNVKSTLAIGKAVQEVDEQALGEKAQKKLAEKVLKSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CIZ1</accession>
    <name>A0A177CIZ1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DNA mismatch repair protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CC84DRAFT_1142918</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Component of the post-replicative DNA mismatch repair system (MMR).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9 10">Belongs to the DNA mismatch repair MutS family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG06828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037193.1">
        <property type="nucleotide sequence ID" value="XM_018176386.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CIZ1"/>
    <dbReference type="FunCoup" id="A0A177CIZ1">
        <property type="interactions" value="960"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CIZ1"/>
    <dbReference type="GeneID" id="28759872"/>
    <dbReference type="InParanoid" id="A0A177CIZ1"/>
    <dbReference type="OrthoDB" id="10252754at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032301">
        <property type="term" value="C:MutSalpha complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000400">
        <property type="term" value="F:four-way junction DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032137">
        <property type="term" value="F:guanine/thymine mispair binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032138">
        <property type="term" value="F:single base insertion or deletion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043570">
        <property type="term" value="P:maintenance of DNA repeat elements"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000710">
        <property type="term" value="P:meiotic mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043111">
        <property type="term" value="P:replication fork arrest"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1420.10:FF:000014">
        <property type="entry name" value="DNA mismatch repair protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1420.10:FF:000019">
        <property type="entry name" value="DNA mismatch repair protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.110:FF:000006">
        <property type="entry name" value="DNA mismatch repair protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1170.10:FF:000002">
        <property type="entry name" value="DNA mismatch repair protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000771">
        <property type="entry name" value="DNA mismatch repair protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1420.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.10">
        <property type="entry name" value="DNA repair protein MutS, domain I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.110">
        <property type="entry name" value="MutS, connector domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007695">
        <property type="entry name" value="DNA_mismatch_repair_MutS-lik_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017261">
        <property type="entry name" value="DNA_mismatch_repair_MutS/MSH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007861">
        <property type="entry name" value="DNA_mismatch_repair_MutS_clamp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007696">
        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016151">
        <property type="entry name" value="DNA_mismatch_repair_MutS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007860">
        <property type="entry name" value="DNA_mmatch_repair_MutS_con_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036678">
        <property type="entry name" value="MutS_con_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003810">
        <property type="entry name" value="PRK05399.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361:SF148">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MSH6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01624">
        <property type="entry name" value="MutS_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05188">
        <property type="entry name" value="MutS_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05192">
        <property type="entry name" value="MutS_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05190">
        <property type="entry name" value="MutS_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037677">
        <property type="entry name" value="DNA_mis_repair_Msh6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00533">
        <property type="entry name" value="MUTSd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55271">
        <property type="entry name" value="DNA repair protein MutS, domain I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53150">
        <property type="entry name" value="DNA repair protein MutS, domain II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="DNA repair protein MutS, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00486">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9 10" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7 9 10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 9 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair proteins mutS family" evidence="12">
        <location>
            <begin position="1039"/>
            <end position="1055"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="41"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="59"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="75"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="154"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="172"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR037677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS00486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OAG06828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="1204" mass="134081" checksum="C4F925212B069C88" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CJN6</accession>
    <name>A0A177CJN6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF1766-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1258596</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG07516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037881.1">
        <property type="nucleotide sequence ID" value="XM_018184842.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CJN6"/>
    <dbReference type="STRING" id="1460663.A0A177CJN6"/>
    <dbReference type="GeneID" id="28768328"/>
    <dbReference type="InParanoid" id="A0A177CJN6"/>
    <dbReference type="OrthoDB" id="2417614at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053006">
        <property type="entry name" value="Meiosis_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018306">
        <property type="entry name" value="Phage_T5_Orf172_DNA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28094">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 113 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28094:SF1">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 113 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10544">
        <property type="entry name" value="T5orf172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00974">
        <property type="entry name" value="T5orf172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bacteriophage T5 Orf172 DNA-binding" evidence="2">
        <location>
            <begin position="481"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="390"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="73"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG07516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="632" mass="70500" checksum="198558A01A65C16C" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CK67</accession>
    <name>A0A177CK67_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative sugar transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CC84DRAFT_655638</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG07362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037727.1">
        <property type="nucleotide sequence ID" value="XM_018187026.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CK67"/>
    <dbReference type="GeneID" id="28770512"/>
    <dbReference type="InParanoid" id="A0A177CK67"/>
    <dbReference type="OrthoDB" id="4139357at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17316">
        <property type="entry name" value="MFS_SV2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000171">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511:SF5">
        <property type="entry name" value="MAJOR FACILITATOR-TYPE TRANSPORTER HXNZ-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511">
        <property type="entry name" value="SYNAPTIC VESICLE GLYCOPROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="151"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="177"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="200"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="236"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="279"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="383"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="430"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="460"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="547"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="113"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="31"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="37"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAG07362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="574" mass="62229" checksum="AD772D6F52B14D5C" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CKB2</accession>
    <name>A0A177CKB2_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Cobalamin-independent methionine synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Methionine synthase, vitamin-B12 independent isozyme</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CC84DRAFT_1088288</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="14">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-methionine from L-homocysteine (MetE route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the vitamin-B12 independent methionine synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.14" evidence="4"/>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG07681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038046.1">
        <property type="nucleotide sequence ID" value="XM_018174250.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CKB2"/>
    <dbReference type="FunCoup" id="A0A177CKB2">
        <property type="interactions" value="539"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CKB2"/>
    <dbReference type="GeneID" id="28757736"/>
    <dbReference type="InParanoid" id="A0A177CKB2"/>
    <dbReference type="OrthoDB" id="1053771at2759"/>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00082"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003871">
        <property type="term" value="F:5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019280">
        <property type="term" value="P:L-methionine biosynthetic process from L-homoserine via O-acetyl-L-homoserine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03311">
        <property type="entry name" value="CIMS_C_terminal_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03312">
        <property type="entry name" value="CIMS_N_terminal_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.210:FF:000002">
        <property type="entry name" value="5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.210:FF:000003">
        <property type="entry name" value="5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.210">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00172">
        <property type="entry name" value="Meth_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013215">
        <property type="entry name" value="Cbl-indep_Met_Synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006276">
        <property type="entry name" value="Cobalamin-indep_Met_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002629">
        <property type="entry name" value="Met_Synth_C/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038071">
        <property type="entry name" value="UROD/MetE-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01371">
        <property type="entry name" value="met_syn_B12ind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003556">
        <property type="entry name" value="PRK05222.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30519">
        <property type="entry name" value="5-METHYLTETRAHYDROPTEROYLTRIGLUTAMATE--HOMOCYSTEINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08267">
        <property type="entry name" value="Meth_synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01717">
        <property type="entry name" value="Meth_synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000382">
        <property type="entry name" value="MeTrfase_B12_ind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51726">
        <property type="entry name" value="UROD/MetE-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 14" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Cobalamin-independent methionine synthase MetE N-terminal" evidence="18">
        <location>
            <begin position="4"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="Cobalamin-independent methionine synthase MetE C-terminal/archaeal" evidence="17">
        <location>
            <begin position="435"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="382"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="397"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="15">
        <location>
            <position position="704"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="19"/>
        </location>
        <ligand>
            <name>5-methyltetrahydropteroyltri-L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:58207"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>5-methyltetrahydropteroyltri-L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:58207"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="440"/>
            <end position="442"/>
        </location>
        <ligand>
            <name>L-homocysteine</name>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="440"/>
            <end position="442"/>
        </location>
        <ligand>
            <name>L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="493"/>
        </location>
        <ligand>
            <name>L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="524"/>
            <end position="525"/>
        </location>
        <ligand>
            <name>5-methyltetrahydropteroyltri-L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:58207"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="570"/>
        </location>
        <ligand>
            <name>5-methyltetrahydropteroyltri-L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:58207"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="608"/>
        </location>
        <ligand>
            <name>L-homocysteine</name>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="608"/>
        </location>
        <ligand>
            <name>L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="651"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="653"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="662"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="675"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="736"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000382-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000382-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR000382-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF01717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF08267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="OAG07681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="766" mass="86134" checksum="FAD585922D197928" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CKG4</accession>
    <name>A0A177CKG4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1163498</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG07287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037652.1">
        <property type="nucleotide sequence ID" value="XM_018178277.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CKG4"/>
    <dbReference type="STRING" id="1460663.A0A177CKG4"/>
    <dbReference type="GeneID" id="28761763"/>
    <dbReference type="InParanoid" id="A0A177CKG4"/>
    <dbReference type="OrthoDB" id="66144at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF110">
        <property type="entry name" value="RHODANESE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="1">
        <location>
            <begin position="64"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG07287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="210" mass="23237" checksum="3107C82BCCEF4622" modified="2016-09-07" version="1">MSSNDRFLDRVFAAKSKDESRQLYDQWASSYDADMQTYSFTAPQIVAEMVPKYLKVSPKDAVVVDAGCGSGLVGVTLHQSGFKTIDGLDLSEGMLKVAEKTGAYRKLEVTDLTQRLNIEDGTYDGLTCSGTFTHGHVGPEPLPELVRIVKAGGILVATILESFWKEFDFEMVVKGLEERGMVEMLENNLHSYRKFGDEESGGLVLVLRKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CKJ2</accession>
    <name>A0A177CKJ2_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transcription initiation factor TFIID subunit 13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_654497</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TAF13 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG07317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037682.1">
        <property type="nucleotide sequence ID" value="XM_018187015.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CKJ2"/>
    <dbReference type="FunCoup" id="A0A177CKJ2">
        <property type="interactions" value="365"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CKJ2"/>
    <dbReference type="GeneID" id="28770501"/>
    <dbReference type="InParanoid" id="A0A177CKJ2"/>
    <dbReference type="OrthoDB" id="10266074at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07978">
        <property type="entry name" value="HFD_TAF13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003195">
        <property type="entry name" value="TFIID_TAF13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11380:SF5">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11380">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID/SUPT3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02269">
        <property type="entry name" value="TFIID-18kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="102"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="106"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="119"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00040136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAG07317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="159" mass="17901" checksum="8ABBF096AAF1119F" modified="2016-09-07" version="1">MTEPRMRQRGKGPQWEQRDLESFLIAYGDTAPPLKATVLTLDEIITDYIIETCHEAAAVATHARRQKIKLDDFKFMLRRDTAKLGRVSELLETDKELKRKRKAFDTDEGAVVDTVEEVPGEKGKRGKKVEGGGEGDEGERKKKRKKKVKTDDASTVVSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CLA0</accession>
    <name>A0A177CLA0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SET domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1144248</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG07599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037964.1">
        <property type="nucleotide sequence ID" value="XM_018176448.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CLA0"/>
    <dbReference type="STRING" id="1460663.A0A177CLA0"/>
    <dbReference type="GeneID" id="28759934"/>
    <dbReference type="InParanoid" id="A0A177CLA0"/>
    <dbReference type="OrthoDB" id="3180714at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd10540">
        <property type="entry name" value="SET_SpSet7-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SET" evidence="1">
        <location>
            <begin position="14"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG07599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="160" mass="18420" checksum="82C43F953B3AE7FE" modified="2016-09-07" version="1">MHLESTRIPLERCPDLVILTDTPKGRGVFATKLITAKTVLDTCPVLILGIEENKRHIEHTSLYHYTYNWPITDKEGKKQKAQAVIFGLGSMFNHSSHDQNVVWDRDLLRQMITYRALRDIQPGEELCISYGDHLTFKDADAPPLPRPEDEIEQLNRIQLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CLA6</accession>
    <name>A0A177CLA6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1163696</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG07567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037932.1">
        <property type="nucleotide sequence ID" value="XM_018178321.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CLA6"/>
    <dbReference type="STRING" id="1460663.A0A177CLA6"/>
    <dbReference type="GeneID" id="28761807"/>
    <dbReference type="InParanoid" id="A0A177CLA6"/>
    <dbReference type="OrthoDB" id="3944128at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="383"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="702"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="383"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="397"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="454"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="493"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="702"/>
            <end position="720"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG07567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="755" mass="77047" checksum="C05CA159EF62B346" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CLH9</accession>
    <name>A0A177CLH9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_703558</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG07637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038002.1">
        <property type="nucleotide sequence ID" value="XM_018187110.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CLH9"/>
    <dbReference type="GeneID" id="28770596"/>
    <dbReference type="InParanoid" id="A0A177CLH9"/>
    <dbReference type="OrthoDB" id="3800559at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG07637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="247" mass="28531" checksum="751BFB7BA083035A" modified="2016-09-07" version="1">MVTKTSGRIAPGEDECRPSLLLGLNVEVLHNIVAELRLDEDAKALHNSYRTSNVQRDVAQPAHFNLFSIPKPDKFLLAKHSKHNSCPLKRTIEYTRAILQRYDVAASVEALAHLTRTNLSWTPKITLSFPRPITTSFRALHSRSQYDGAVGILQVMRLIKTVDLCFREHYTFWLKAHEVFVENMENALLKFQDFCRALRHVFCQTHNRPKVRRYVLLHDGRAGKTQGVIDYHSIPNLPYTLHMFRVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CMP9</accession>
    <name>A0A177CMP9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1162051</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038402.1">
        <property type="nucleotide sequence ID" value="XM_018177893.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CMP9"/>
    <dbReference type="GeneID" id="28761379"/>
    <dbReference type="InParanoid" id="A0A177CMP9"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG08037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="74" mass="7958" checksum="AF6BB837D07C67A1" modified="2016-09-07" version="1">MTVEDRRAATARVVMTTAVALLRHVTSMIVAIGMGVRLLAEAPLMISALPVLAMTQTRTILVVDPLRAAMMTHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CMV9</accession>
    <name>A0A177CMV9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_569267</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038657.1">
        <property type="nucleotide sequence ID" value="XM_018186718.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CMV9"/>
    <dbReference type="GeneID" id="28770204"/>
    <dbReference type="InParanoid" id="A0A177CMV9"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG08292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="204" mass="22104" checksum="A72591FF7B7A2EC8" modified="2016-09-07" version="1">MISWRGSPTSKGCEGPLGRTVGEAMERAVVTAAVAGEGMRSVELRSTDQLGQKRRVERLVDCASSTKGRKVGQQRHLGRPAVAVVQGQDAINERSRSGGCTARQVARGSGNGQRDKEKGSRVFLERGMRLLVSRRTLARCRLRPRANHSVPSGAARASQPAVRTHPQRRLMSCLCKRAAHQRVESQPILPVTRTCCVTGEIASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CQ46</accession>
    <name>A0A177CQ46_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Nop14-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_1115938</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in nucleolar processing of pre-18S ribosomal RNA. Has a role in the nuclear export of 40S pre-ribosomal subunit to the cytoplasm.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NOP14 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG09020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039385.1">
        <property type="nucleotide sequence ID" value="XM_018175444.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CQ46"/>
    <dbReference type="FunCoup" id="A0A177CQ46">
        <property type="interactions" value="1109"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CQ46"/>
    <dbReference type="GeneID" id="28758930"/>
    <dbReference type="InParanoid" id="A0A177CQ46"/>
    <dbReference type="OrthoDB" id="441771at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030692">
        <property type="term" value="C:Noc4p-Nop14p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034511">
        <property type="term" value="F:U3 snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000480">
        <property type="term" value="P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000472">
        <property type="term" value="P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007276">
        <property type="entry name" value="Nop14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23183">
        <property type="entry name" value="NOP14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23183:SF0">
        <property type="entry name" value="NUCLEOLAR PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04147">
        <property type="entry name" value="Nop14"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="63"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="128"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="269"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="799"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="32"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="128"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="204"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="217"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="302"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="360"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="405"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="842"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAG09020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="842" mass="95257" checksum="0FC0C389D6B3AE8F" modified="2016-09-07" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CQL5</accession>
    <name>A0A177CQL5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1111492</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG09814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040179.1">
        <property type="nucleotide sequence ID" value="XM_018175282.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CQL5"/>
    <dbReference type="GeneID" id="28758768"/>
    <dbReference type="InParanoid" id="A0A177CQL5"/>
    <dbReference type="OrthoDB" id="3711089at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="209"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="381"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="221"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="385"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG09814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="405" mass="45601" checksum="2A60D848C6A43ED4" modified="2016-09-07" version="1">MLNMDISSDTKIPLTAKTVRAIARASFQQPFDKLARAVSETKWLDFDVNDPGSIGTDRAVYRSLSRSKHNRLLVVGYYAPGYGDERPTDRVAAHVHTDPAEVRFYRIIEAKDGSRTLEDVNSTSAVDFDPPFCDVGDGQGDHRAGHRVTALIEWFFLDAGLVPELTRPDGDPGKFTRNFRQACMWVGNDGSQPVDVYLRRSSGVNIKEEEKETIPVRPKRSSTTSASFRNSAVDEFRLPPIKRSATDTSPVKRQREENPLARPTKHRRTLSEQVTPLTMHHHLMNSGSNPPSPRTPTLNDAERMNRALGSRIIHLHEQYRTLRSHFEETGSKQADLKTELKDMKERVIHAESRSEELDREVNSLRTRLQQAEEEAAKLRAEILAGSNGPNSGSSNGVDKRATRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CQW1</accession>
    <name>A0A177CQW1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Probable beta-glucosidase G</fullName>
            <ecNumber evidence="5">3.2.1.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Beta-D-glucoside glucohydrolase G</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Cellobiase G</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">Gentiobiase G</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">CC84DRAFT_1235297</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Beta-glucosidases are one of a number of cellulolytic enzymes involved in the degradation of cellulosic biomass. Catalyzes the last step releasing glucose from the inhibitory cellobiose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Glycan metabolism; cellulose degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="5"/>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG09611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039976.1">
        <property type="nucleotide sequence ID" value="XM_018183843.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CQW1"/>
    <dbReference type="STRING" id="1460663.A0A177CQW1"/>
    <dbReference type="GeneID" id="28767329"/>
    <dbReference type="InParanoid" id="A0A177CQW1"/>
    <dbReference type="OrthoDB" id="416222at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000757">
        <property type="entry name" value="Beta-glucosidase G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.300:FF:000002">
        <property type="entry name" value="Probable beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050288">
        <property type="entry name" value="Cellulose_deg_GH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715">
        <property type="entry name" value="BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715:SF12">
        <property type="entry name" value="BETA-GLUCOSIDASE G-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="Beta-D-glucan exohydrolase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="7 19" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="19">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008058492" description="Probable beta-glucosidase G" evidence="19">
        <location>
            <begin position="18"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type III-like" evidence="20">
        <location>
            <begin position="709"/>
            <end position="779"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00024983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00039579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00041276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00041601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00041808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="SMART" id="SM01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="OAG09611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="790" mass="84193" checksum="27ADB4B5C0BC0AA5" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CR71</accession>
    <name>A0A177CR71_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_433014</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG09269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039634.1">
        <property type="nucleotide sequence ID" value="XM_018186234.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CR71"/>
    <dbReference type="STRING" id="1460663.A0A177CR71"/>
    <dbReference type="GeneID" id="28769720"/>
    <dbReference type="InParanoid" id="A0A177CR71"/>
    <dbReference type="OrthoDB" id="3794485at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="275"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="275"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="289"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="305"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG09269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="324" mass="36177" checksum="5337D3329D202EA4" modified="2016-09-07" version="1">MVLKQFDMDFILRQQLTSDELPPWAGIVFKYPVDSDDLSEKLRAAYPDCKTHRERKHRATIDFLNAELSRMQSGSSIIDPNSPSNVKHPTQGSTPTAARLHAEVLSEGTEILSASDGTPSSLIESTISPKLAERIRKASQATADSEQSQAHASPTAAQQFVWSAHDGRSMRPKTKRKMTVEERNAYKNTRKRGACDKCRKQKGRCTHFNDNDQWKILVDSKRRSADLDAPSEEGMKLIKMEYSSDVHHRPSSGQTLEVERALSTRPLSMYEHVRPLDDAARDEQRVTDSLPSSVSSRSGSNGNSECLTPTNSRAKSPVIANERE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CRB3</accession>
    <name>A0A177CRB3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Jacalin-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1161075</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040429.1">
        <property type="nucleotide sequence ID" value="XM_018177646.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CRB3"/>
    <dbReference type="GeneID" id="28761132"/>
    <dbReference type="InParanoid" id="A0A177CRB3"/>
    <dbReference type="OrthoDB" id="3758675at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.15.10">
        <property type="entry name" value="Proaerolysin, chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004991">
        <property type="entry name" value="Aerolysin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03318">
        <property type="entry name" value="ETX_MTX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56973">
        <property type="entry name" value="Aerolisin/ETX pore-forming domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG10064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="326" mass="35414" checksum="199918A18AEC30B8" modified="2016-09-07" version="1">MWHVRGIHLTFSDGWVSPIRGSTTGDITEQGVIEWDGPVAKINRANNWDGYGGDAVGRIWIDAGGKSLNVGSDTGSYGGEPVELHTGVLLGAHGRSGDFLDTLEWMLMSADIIDSEVTQFKFPPETANLEEWNEKQKGMENISLDDLYYSNDSPAGSSNQTFEFSKGVEKTVSKTVTDQDSHAFGVSIGFKISAEIDVPLLAKVTAETSTSYSYTYTKTHSESISTSDKMPITYKQSGTLAPGQAMHCTALTSSGTFSSDFTAVTRITLGDGKTFDIEQPHHYESVGWTNAQSSCKLVPRDQIPSGALMGETMPLKKRSIAGRLWM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CRF3</accession>
    <name>A0A177CRF3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Protein phosphatase 2C isoform beta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_1082385</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the PP2C family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG09357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039722.1">
        <property type="nucleotide sequence ID" value="XM_018173978.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CRF3"/>
    <dbReference type="FunCoup" id="A0A177CRF3">
        <property type="interactions" value="239"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CRF3"/>
    <dbReference type="GeneID" id="28757464"/>
    <dbReference type="InParanoid" id="A0A177CRF3"/>
    <dbReference type="OrthoDB" id="10264738at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.40.10:FF:000078">
        <property type="entry name" value="Protein phosphatase 2C, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000222">
        <property type="entry name" value="PP2C_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832:SF837">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C-LIKE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01032">
        <property type="entry name" value="PPM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 5" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="7">
        <location>
            <begin position="63"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="36"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="220"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="455"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="43"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="226"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAG09357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="481" mass="51803" checksum="D13925F57E613EF0" modified="2016-09-07" version="1">MFSSAKQSLHLGSSPTSGTGAVEKTVQTPMQKLGKADPALSVPQGSLNNSAGESHPGPHSTFRVGVTEDKNKKCRRTMEDTHAYLYNFLSTPAPNYNPEKSRGSLSDGSSSTDQQVVETDNGYFAIFDGHAGTFAADWCGKKLHLLLEETIRRNPNTPIPELLDQTFTLVDQQLEKLPLKNSGCTAVIAVLRWEDRVPNQASSTGSTLFSAAAVKGVAEAGDKQSESTSTAESTSTAEGAQEHLIEAKLRNDASRQRVLYTANVGDARIVLCRNGRALRLSYDHKGSDDNEGRRVASAGGLILNNRVNGVLAVTRALGDAYMKDLVTGHPYTTETVIQADQDEFLILACDGLWDVCSDQEAVDLVRGIHDPQVASKTLVEHALARFSTDNLSCMVVRFDNKALKQRKTEAQLGVDRDTPGTKPGISEADAIVAQAKKEVGEPDVPVERVAQEIIHEEEAGQEENGPELNADAVKAARKNPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CRQ3</accession>
    <name>A0A177CRQ3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SGNH hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1161187</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040568.1">
        <property type="nucleotide sequence ID" value="XM_018177672.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CRQ3"/>
    <dbReference type="STRING" id="1460663.A0A177CRQ3"/>
    <dbReference type="GeneID" id="28761158"/>
    <dbReference type="InParanoid" id="A0A177CRQ3"/>
    <dbReference type="OrthoDB" id="671439at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001087">
        <property type="entry name" value="GDSL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045136">
        <property type="entry name" value="Iah1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14209">
        <property type="entry name" value="ISOAMYL ACETATE-HYDROLYZING ESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14209:SF19">
        <property type="entry name" value="ISOAMYL ACETATE-HYDROLYZING ESTERASE 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00657">
        <property type="entry name" value="Lipase_GDSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG10203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="272" mass="30115" checksum="3E7CB0141D5942D1" modified="2016-09-07" version="1">MGCNSSRKQLPQFVLFGDSLTEWSFDDSTQGFGWYLTDLYKGKAKIVNEGYAGYTSEHVKPEFSRIMTRITAPFAPSTLLFTIFLGANDACFVGKTEYVPLPQFSDNIRSFVEEILIQDNLADAKIVLITPPPVNVPDPLPGDDEGLGPAMAKALKGKEPKQDRAYLTYMSKKRYADGIMSIAKEYEETDRVVGLNYWRALVDAGLEEQGRTGELDEDLFPGCGLAGAKEFGSGWFTDGLHLDKKAYNVLSKALTETVIGKWPELSPERIGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CS14</accession>
    <name>A0A177CS14_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1202261</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG09559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039924.1">
        <property type="nucleotide sequence ID" value="XM_018181761.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CS14"/>
    <dbReference type="GeneID" id="28765247"/>
    <dbReference type="InParanoid" id="A0A177CS14"/>
    <dbReference type="OrthoDB" id="10508816at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="227"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="469"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="255"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="287"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG09559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="518" mass="57104" checksum="E002201FB87BBC3E" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CS61</accession>
    <name>A0A177CS61_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1213693</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040730.1">
        <property type="nucleotide sequence ID" value="XM_018182562.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CS61"/>
    <dbReference type="STRING" id="1460663.A0A177CS61"/>
    <dbReference type="GeneID" id="28766048"/>
    <dbReference type="InParanoid" id="A0A177CS61"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF73">
        <property type="entry name" value="HET DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_8G01020)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="13"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG10365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="247" mass="28444" checksum="065C0BD19AEA2B0A" modified="2016-09-07" version="1">MRRSNRHEERWSGWFWIDALCIIQDDEHPEKDIQIKFMPKIYGGAREVIAWIGPGDSITDAAMRYIRNQPSTFLRAVAEGTAEARLESFENTFRDVAFCVRDIFNKSYWGRLWILQELAMAQNTTIVCGNEELPWKTFIDFATQVAAADFGPSKTLRRAQGEVAAKQPVWLLTLIYEKRTRGLNLAELVFLSKDSVCGRDKKDYIRALLGMVQEGSGWRLDPEKHRSACSMLSHATRVMIDVRSWHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CSD8</accession>
    <name>A0A177CSD8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative benzoate 4-monooxygenase cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CC84DRAFT_1235664</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG09800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040165.1">
        <property type="nucleotide sequence ID" value="XM_018183856.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CSD8"/>
    <dbReference type="STRING" id="1460663.A0A177CSD8"/>
    <dbReference type="GeneID" id="28767342"/>
    <dbReference type="InParanoid" id="A0A177CSD8"/>
    <dbReference type="OrthoDB" id="3945418at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11062">
        <property type="entry name" value="CYP58-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF157">
        <property type="entry name" value="N-ACETYLTRYPTOPHAN 6-HYDROXYLASE IVOC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7 8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8 10" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="461"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAG09800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="522" mass="58968" checksum="F8817561ACF8A7DB" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CTD5</accession>
    <name>A0A177CTD5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1173134</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041158.1">
        <property type="nucleotide sequence ID" value="XM_018180009.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CTD5"/>
    <dbReference type="STRING" id="1460663.A0A177CTD5"/>
    <dbReference type="GeneID" id="28763495"/>
    <dbReference type="InParanoid" id="A0A177CTD5"/>
    <dbReference type="OrthoDB" id="3794541at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="327"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="155"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="327"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="339"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG10793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="350" mass="39182" checksum="1AE40ADC2BB64F51" modified="2016-09-07" version="1">MDELTTKMSKTAIPPKTMVLKRPDISLNHISEFVTHIPPPVDERTRIIAVCGCVDFETAYEVFDFDEAWLVYQRRLRLQALAPEFWCSSRVLDHGRRAPASGDKIQPIPTCVENDTLGSSWSHISTLPMISFQQRWESLEEVLPTADPTSWLNRDPSASSEFSSSQSSASSDWDLSDLFHRMGSMPAAWTLVKRQAQQYLDSHPGSDESANNKIHGFLRMLLDGRAPRTNANLRAVEQVLAFRISLSAIVTEMVQVSGLGLPGGKVCSEFSIGGWERLCNKKPDHNISKAYDIAADLIYSNVLPDPATREQGERWNKPHRYIAGRHCRQSKLQHHSRTGADSGQTARGDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CUP3</accession>
    <name>A0A177CUP3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">phosphoadenylyl-sulfate reductase (thioredoxin)</fullName>
            <ecNumber evidence="3">1.8.4.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">3'-phosphoadenylylsulfate reductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">PAPS reductase, thioredoxin dependent</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">PAdoPS reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CC84DRAFT_1184522</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>[thioredoxin]-disulfide + sulfite + adenosine 3',5'-bisphosphate + 2 H(+) = [thioredoxin]-dithiol + 3'-phosphoadenylyl sulfate</text>
            <dbReference type="Rhea" id="RHEA:11724"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17359"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
            <dbReference type="ChEBI" id="CHEBI:58343"/>
            <dbReference type="EC" id="1.8.4.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Sulfur metabolism; hydrogen sulfide biosynthesis; sulfite from sulfate: step 3/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PAPS reductase family. CysH subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.8.4.8" evidence="3"/>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040872.1">
        <property type="nucleotide sequence ID" value="XM_018180753.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CUP3"/>
    <dbReference type="FunCoup" id="A0A177CUP3">
        <property type="interactions" value="622"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CUP3"/>
    <dbReference type="GeneID" id="28764239"/>
    <dbReference type="InParanoid" id="A0A177CUP3"/>
    <dbReference type="OrthoDB" id="7869097at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004604">
        <property type="term" value="F:phosphoadenylyl-sulfate reductase (thioredoxin) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019344">
        <property type="term" value="P:cysteine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006750">
        <property type="term" value="P:glutathione biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019379">
        <property type="term" value="P:sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd23945">
        <property type="entry name" value="PAPS_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000151">
        <property type="entry name" value="Phosphoadenosine phosphosulfate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00063">
        <property type="entry name" value="CysH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004511">
        <property type="entry name" value="PAPS/APS_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002500">
        <property type="entry name" value="PAPS_reduct_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011800">
        <property type="entry name" value="PAPS_reductase_CysH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00434">
        <property type="entry name" value="cysH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02057">
        <property type="entry name" value="PAPS_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002537">
        <property type="entry name" value="PRK02090.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46509">
        <property type="entry name" value="PHOSPHOADENOSINE PHOSPHOSULFATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46509:SF1">
        <property type="entry name" value="PHOSPHOADENOSINE PHOSPHOSULFATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01507">
        <property type="entry name" value="PAPS_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000857">
        <property type="entry name" value="PAPS_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0198">Cysteine biosynthesis</keyword>
    <keyword evidence="7" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphoadenosine phosphosulphate reductase" evidence="13">
        <location>
            <begin position="56"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00052536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00078053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00082472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00082553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OAG10507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="287" mass="32394" checksum="B873FE50E217AE8B" modified="2016-09-07" version="1">MIRDDESGYASGESSHESLPEIVFSKAHLKFLNHQLAQLEPQDILRWCITSLPGLYQSTAFGLTGLVTVDMLSKLDGPLKSNVDLIFYDTLYQFQETLDLVEKVRQRYGNTIHVYKPRGCNTTEDFEAKYGKNFWDVNDEKYDYVAKVEPAARANAELNVKALLTGRRKSQGGKRGDLDIIEVTDSGVIKINPLANWSFAQVKEYVDANKVPYNDLLDRGYKSVGDWHSTQPVAAGEDERAGRWKGKNKTECGIHNPQSRYAQFLAQQQQQQEAEALAQQLEKTVVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CUU8</accession>
    <name>A0A177CUU8_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UBX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1112923</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040894.1">
        <property type="nucleotide sequence ID" value="XM_018175336.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CUU8"/>
    <dbReference type="STRING" id="1460663.A0A177CUU8"/>
    <dbReference type="GeneID" id="28758822"/>
    <dbReference type="InParanoid" id="A0A177CUU8"/>
    <dbReference type="OrthoDB" id="2445133at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01767">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001012">
        <property type="entry name" value="UBX_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46424">
        <property type="entry name" value="UBX DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46424:SF1">
        <property type="entry name" value="UBX DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00789">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23187">
        <property type="entry name" value="UBX7_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50033">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBX" evidence="2">
        <location>
            <begin position="244"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="208"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="384"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="164"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="401"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="424"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG10529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="455" mass="48713" checksum="956D146B1FEAE974" modified="2016-09-07" version="1">MFHEGNLQSGIARAIQEQKLVGCFIQDGSAESTTWEDEWLKSGWLSSLLEQKAVLLRLQAGSTEAGFLAAFCSISETPTFIVIQNGQLQEQLSSGISQTDFVNRIRKVLGASPIPGTAEPAASTPVVSAPEATRTATPPQPSPPTRTPAAPTPPLSSVAKGKQKATAPATKPEPATSKAQQAAREALRKKKEEERAALERIKARIEADKAERKAQAEARKAEREKLTESGPTTSQFSATSSRGSNAKEVHLNVRMFDGATVRSSFPRSAKLQDDVRPWIDQEFVARAENPNERHPPYYFKQILAPLPSRELSAGDECQTLGDIDLAPSATLVLVPVKGYTDAYAGGSRGIVSGPAGSVFNIVGGAFNLAGSAVGYVSNTLSSVLGGGGSAPQDNQQQQEQTGEGRSLGNTPQEPPGSTGIRVRTLADQRSREPRNEQLYNGNQLNFEPRDEDSNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CUX9</accession>
    <name>A0A177CUX9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_491712</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041045.1">
        <property type="nucleotide sequence ID" value="XM_018186500.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CUX9"/>
    <dbReference type="STRING" id="1460663.A0A177CUX9"/>
    <dbReference type="GeneID" id="28769986"/>
    <dbReference type="InParanoid" id="A0A177CUX9"/>
    <dbReference type="OrthoDB" id="446723at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277">
        <property type="entry name" value="ALPHA/BETA HYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277:SF81">
        <property type="entry name" value="PROTEIN ABHD13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG10680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="345" mass="37585" checksum="41142DC465CE772B" modified="2016-09-07" version="1">MDVYLEHERELVSRVQDDVVESGEFTKTLGARLLREDAGSKLVINFHGNAGHLALGWRPSIYRSMSGIPRTHTLVCDYRGFGLSTTTNAPHRPTEPGLITDGISIVAFALHTLHHPASRITLLGQSLGTAVTAATALYFTDPTSPLLPSSLPQSPSPKHPESFAAIVLAAAFTDLPTLLRSYKIKGFIPILSPLQNYPKIASFLSSRIEDTWPTLSRLQALIPAATHASAPLHVTILHARNDQEFPFQIAETVYAPLETLLLAEEGASSVSERRSIQGGERVSRGAFAYRRVETNDGERSVEVEVVRYGGHSEGVGWGQVSLAVRRAWRRTGADGTGKEYTGDEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CVS3</accession>
    <name>A0A177CVS3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SUI1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1113438</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041194.1">
        <property type="nucleotide sequence ID" value="XM_018175355.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CVS3"/>
    <dbReference type="FunCoup" id="A0A177CVS3">
        <property type="interactions" value="482"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CVS3"/>
    <dbReference type="GeneID" id="28758841"/>
    <dbReference type="InParanoid" id="A0A177CVS3"/>
    <dbReference type="OrthoDB" id="199771at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001731">
        <property type="term" value="P:formation of translation preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11608">
        <property type="entry name" value="eIF2D_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21156">
        <property type="entry name" value="PUA_eIF2d-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.780.10:FF:000008">
        <property type="entry name" value="eukaryotic translation initiation factor 2D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.400.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.780.10">
        <property type="entry name" value="SUI1-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039757">
        <property type="entry name" value="EIF2D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039759">
        <property type="entry name" value="eIF2D_SUI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048248">
        <property type="entry name" value="PUA_eIF2d-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001950">
        <property type="entry name" value="SUI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036877">
        <property type="entry name" value="SUI1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058886">
        <property type="entry name" value="SWIB_eIF2D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036885">
        <property type="entry name" value="SWIB_MDM2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057429">
        <property type="entry name" value="WH_eIF2D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12217">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12217:SF4">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26292">
        <property type="entry name" value="PUA_elF2D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01253">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26291">
        <property type="entry name" value="SWIB_eIF2D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25304">
        <property type="entry name" value="WHD_eIF2D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55159">
        <property type="entry name" value="eIF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47592">
        <property type="entry name" value="SWIB/MDM2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50296">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SUI1" evidence="2">
        <location>
            <begin position="552"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="255"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="407"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="258"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG10829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="644" mass="70153" checksum="D9C0C13987E787D9" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CVU0</accession>
    <name>A0A177CVU0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1083020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041204.1">
        <property type="nucleotide sequence ID" value="XM_018173999.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CVU0"/>
    <dbReference type="STRING" id="1460663.A0A177CVU0"/>
    <dbReference type="GeneID" id="28757485"/>
    <dbReference type="InParanoid" id="A0A177CVU0"/>
    <dbReference type="OrthoDB" id="5420247at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42029">
        <property type="entry name" value="AN04G07800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42029:SF3">
        <property type="entry name" value="AN04G07800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="97"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="145"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="175"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="271"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="342"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="280"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="290"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="350"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG10839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="421" mass="48467" checksum="FED481888E714761" modified="2016-09-07" version="1">MPITPEGLIIEAWSQGYLVGSLIIMTFITLANMRRGVLLHKMILIELLFGIWQGFWLFPGGQASSWWLSVAAIPLNMSWFLHNIISWMKIKPFLSRFWSLVFLYTCLLSFPYWVIEIYANFSYFNGNSKWFTRTRPLELLFRDPWWIITTVYLFTIIKTHYAMTIRDIIRISPRFGIMLASMIISISFVICDVCAVTGALRIGGASTGINPFWKLAFVFKCLTDSVILDDFKMALDRLRAFKISRLGSYSADDSDRRIRNDNNLVQTWEKAEREARENQRNLSDMGTSSDGHDPHEKGEGSGRFHFPFQNSHPGKQKEPVSRPDQSFFQQGEQYRDPLSMVRSAFDDDSGPSSVQSLNATHQPKKQNQGGDQTWFDETDPTDTRDVDVLELYANAQRDVEGQRAPQSPVRKDFPRRSHTTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CWB1</accession>
    <name>A0A177CWB1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1078508</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG11182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041547.1">
        <property type="nucleotide sequence ID" value="XM_018173802.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CWB1"/>
    <dbReference type="GeneID" id="28757288"/>
    <dbReference type="InParanoid" id="A0A177CWB1"/>
    <dbReference type="OrthoDB" id="3672650at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="253"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG11182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="322" mass="37786" checksum="1C9F6B12C7EEB229" modified="2016-09-07" version="1">MHEKKLSVMSNGSEDFSVQRQSMLLRELEMLLDLNPRELSSNLLALPRELRNRIYDFALPEITNGHRPELHTCLWGADMVHEPWRHDIFGYGYGVPKKHRFHPHLQMINRQLRTEMLARYFRRSKLTLHAELRNSQNNNGHFEHSPHILRLPMLKFVTHIRFYVEWNYTVLSKNDRIDDQIRIAKDLMATMDTLLTSLEAVENIELSVLFFWKLRSGKHYMLSMQDLFDLEDVFKRHAESRWLRILRSNNSTVTSPNPSAGVGYKLSSEDKGTDQSGGMEIFVSQDLEEAMRSKRKSMIDFYGNYGISDPLPHPAYEHGKMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CWN7</accession>
    <name>A0A177CWN7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_8338</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG11312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041677.1">
        <property type="nucleotide sequence ID" value="XM_018187580.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CWN7"/>
    <dbReference type="GeneID" id="28771066"/>
    <dbReference type="InParanoid" id="A0A177CWN7"/>
    <dbReference type="OrthoDB" id="10389108at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG11312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="149" mass="16137" checksum="676D042CFC31691B" modified="2016-09-07" version="1">MRSNVDAKLEKVASRRVTSGAVFRFERAWAIEVPAIGGAARGAETLAPAKVQERNAQHSRAVASRPPPARIETPLRHRLRTDASTSTALSSQFSESVLVSLARCGRQRRGGIATRTSPCRGEELLSARRLILGATTQPRSPRTSPSLQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CXA4</accession>
    <name>A0A177CXA4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Serine hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1225444</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG11831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042196.1">
        <property type="nucleotide sequence ID" value="XM_018183570.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CXA4"/>
    <dbReference type="STRING" id="1460663.A0A177CXA4"/>
    <dbReference type="GeneID" id="28767056"/>
    <dbReference type="InParanoid" id="A0A177CXA4"/>
    <dbReference type="OrthoDB" id="414698at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005645">
        <property type="entry name" value="FSH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050593">
        <property type="entry name" value="LovG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48070:SF4">
        <property type="entry name" value="ESTERASE ALNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48070">
        <property type="entry name" value="ESTERASE OVCA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03959">
        <property type="entry name" value="FSH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine hydrolase" evidence="2">
        <location>
            <begin position="3"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG11831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="257" mass="28715" checksum="F6EDE1BF6DE540CD" modified="2016-09-07" version="1">MPTRFLCLAGAFANDEKFKVQMAPFINEMESDGTADFYFAHGQHEANPPPGFEEFFGGPPFYRWMEQVQGPVEHDGLEKMRDFPQGASPEDTLRMFAPIGSSEALATTASQALDYVKGIIKEHGPFEAIIGYSEGAILAGTVIMREADWSVQGDYKNHFKLAMFFGGWPPLKKDLTGFMYSDETDEVIPIPVCNVIGSLDPYVDGSMALYNVCDPDTAVLFDHAKGHTLPRTKDTVKELGDTIRDMIREVREREQEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CXJ9</accession>
    <name>A0A177CXJ9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Glycoside hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_1226428</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042659.1">
        <property type="nucleotide sequence ID" value="XM_018183589.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CXJ9"/>
    <dbReference type="FunCoup" id="A0A177CXJ9">
        <property type="interactions" value="124"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CXJ9"/>
    <dbReference type="GeneID" id="28767075"/>
    <dbReference type="InParanoid" id="A0A177CXJ9"/>
    <dbReference type="OrthoDB" id="62120at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004338">
        <property type="term" value="F:glucan exo-1,3-beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050386">
        <property type="entry name" value="Glycosyl_hydrolase_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297">
        <property type="entry name" value="GLUCAN ENDO-1,6-BETA-GLUCOSIDASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297:SF8">
        <property type="entry name" value="GLYCOSIDE HYDROLASE FAMILY 5 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="3 5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008058714" evidence="6">
        <location>
            <begin position="21"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 5" evidence="7">
        <location>
            <begin position="99"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAG12294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="430" mass="49981" checksum="2C08DAA3AE32A2D8" modified="2016-09-07" version="1">MHLRFSIAHVLELFWCAALATPLDSFSERGVAWDWSSTTNKVRGVNIGGWLVLEPFITPSIFWQYSSNDWTVGDEWSLCKKIGKTECRKALRAHWDSFVKLEDFRKIKKAGFNAVRIPVGYWSFLEIEWEYVSGAAPYLDKAIGWARKTGLKVIIDLHGAPKSQNGFDHSGHAIEWPRWGDGDSIPNTHKVLKILEEKYAKKSMNDVVIAIQPLNEPFLVKLDDNMVKQFYRDSYYNLRLISNDMPMMIHDGFERPSWMNNFLTPDDNNAHNVIIDHHEYQIFNSFEVAKSTDEHRQAVCRAADYWADSDKWIVVGEWSGAMTDCAPHLNGFKEGNRHEGTYKDDWWVGSCWGPILSGEVQHWEQWWKDDVRKYIETQLDVFENKTKGWIFWNFKTEGSAGDWDLFQLLDGGVFPQPITDRKFGKYCLNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CXM0</accession>
    <name>A0A177CXM0_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NAD(P)-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1159658</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042679.1">
        <property type="nucleotide sequence ID" value="XM_018177291.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CXM0"/>
    <dbReference type="STRING" id="1460663.A0A177CXM0"/>
    <dbReference type="GeneID" id="28760777"/>
    <dbReference type="InParanoid" id="A0A177CXM0"/>
    <dbReference type="OrthoDB" id="2735536at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050425">
        <property type="entry name" value="NAD(P)_dehydrat-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366:SF562">
        <property type="entry name" value="ALDEHYDE REDUCTASE II (AFU_ORTHOLOGUE AFUA_1G11360)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366">
        <property type="entry name" value="NAD DEPENDENT EPIMERASE/DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG12314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="225" mass="25439" checksum="D2ECED094E989A20" modified="2016-09-07" version="1">MKEPSVREFVITSSLVSATLPVPGNTTRVERDTWNEMVLEMAWAPPPYEAERGGIVYAASKVATEKAFWDFVEKRKPHFTANAILPPMILGEPLHKSHAEVKAAYIRQLMTGDTAFLETMPATVAVDVKDLALLHIAAILDPSIRNVRFNTWAHFCNYNDMLPIMRAQLPERRFIDDMPGLTKLSLTTDTEQQVELLKKWGTNGGWVNLKQTVEENLMPLAEWGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CXX8</accession>
    <name>A0A177CXX8_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ubiquinone biosynthesis O-methyltransferase, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">3-demethylubiquinol 3-O-methyltransferase</fullName>
            <ecNumber evidence="5">2.1.1.64</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">3-demethylubiquinone 3-O-methyltransferase</fullName>
            <ecNumber evidence="5">2.1.1.-</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Polyprenyldihydroxybenzoate methyltransferase</fullName>
            <ecNumber evidence="5">2.1.1.114</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">COQ3</name>
        <name evidence="7" type="ORF">CC84DRAFT_1254405</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">O-methyltransferase required for two non-consecutive steps during ubiquinone biosynthesis. Catalyzes the 2 O-methylation of 3,4-dihydroxy-5-(all-trans-polyprenyl)benzoic acid into 4-hydroxy-3-methoxy-5-(all-trans-polyprenyl)benzoic acid. Also catalyzes the last step of ubiquinone biosynthesis by mediating methylation of 3-demethylubiquinone into ubiquinone. Also able to mediate the methylation of 3-demethylubiquinol into ubiquinol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 3,4-dihydroxy-5-(all-trans-polyprenyl)benzoate + S-adenosyl-L-methionine = a 4-hydroxy-3-methoxy-5-(all-trans-polyprenyl)benzoate + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:44452"/>
            <dbReference type="Rhea" id="RHEA-COMP:10930"/>
            <dbReference type="Rhea" id="RHEA-COMP:10931"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64694"/>
            <dbReference type="ChEBI" id="CHEBI:84443"/>
            <dbReference type="EC" id="2.1.1.114"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 3-demethylubiquinol + S-adenosyl-L-methionine = a ubiquinol + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:44380"/>
            <dbReference type="Rhea" id="RHEA-COMP:9566"/>
            <dbReference type="Rhea" id="RHEA-COMP:10914"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17976"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:84422"/>
            <dbReference type="EC" id="2.1.1.64"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 3-demethylubiquinone + S-adenosyl-L-methionine = a ubiquinone + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:81215"/>
            <dbReference type="Rhea" id="RHEA-COMP:9565"/>
            <dbReference type="Rhea" id="RHEA-COMP:19654"/>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:231825"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Mitochondrion inner membrane</location>
            <topology evidence="5">Peripheral membrane protein</topology>
            <orientation evidence="5">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.64" evidence="5"/>
    <dbReference type="EC" id="2.1.1.-" evidence="5"/>
    <dbReference type="EC" id="2.1.1.114" evidence="5"/>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042426.1">
        <property type="nucleotide sequence ID" value="XM_018184462.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CXX8"/>
    <dbReference type="FunCoup" id="A0A177CXX8">
        <property type="interactions" value="326"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CXX8"/>
    <dbReference type="GeneID" id="28767948"/>
    <dbReference type="InParanoid" id="A0A177CXX8"/>
    <dbReference type="OrthoDB" id="3265906at2759"/>
    <dbReference type="UniPathway" id="UPA00232"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031314">
        <property type="term" value="C:extrinsic component of mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061542">
        <property type="term" value="F:3-demethylubiquinol 3-O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120537">
        <property type="term" value="F:3-demethylubiquinone 3-O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010420">
        <property type="term" value="F:polyprenyldihydroxybenzoate methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00472">
        <property type="entry name" value="UbiG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010233">
        <property type="entry name" value="UbiG_MeTrfase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01983">
        <property type="entry name" value="UbiG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43464">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43464:SF19">
        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS O-METHYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 5 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 5 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 5" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="48"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAG12061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="311" mass="34262" checksum="41E44BEAB27AAAD9" modified="2016-09-07" version="1">MKPSDSLRAIRPIQRHLTTPSYRLIPARPAQAQAPLFASATTPVSPIRFSSTASSQPKESSKSTVDPTEVSHFNALASSWWDPVGPSRLLHLMNPLRHTFISRCRAASSSVSSNSNLRYLDIGCGGGIFAESAARLAHTASVTAIDPTPEVLKIAEAHKRRDPTLAAPGKLTYINTSIEDLPQPKTPQEGYDIVSLFEVLEHVNAPGPFLEHIMPHVKPGGWLVLSTISRTWTSWLVTNVMAEDVLGIVPKGTHDWAKYVNESELRDWFYGKPGWGELKTMGVMYVPGFGWKEVTGSEGWGNYFFAVRRAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CY65</accession>
    <name>A0A177CY65_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CC84DRAFT_1170626</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG11780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042145.1">
        <property type="nucleotide sequence ID" value="XM_018179865.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CY65"/>
    <dbReference type="STRING" id="1460663.A0A177CY65"/>
    <dbReference type="GeneID" id="28763351"/>
    <dbReference type="InParanoid" id="A0A177CY65"/>
    <dbReference type="OrthoDB" id="5226580at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF10">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="38"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAG11780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="648" mass="73478" checksum="98F68C9099D562BC" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CY83</accession>
    <name>A0A177CY83_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1170945</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042526.1">
        <property type="nucleotide sequence ID" value="XM_018179885.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CY83"/>
    <dbReference type="GeneID" id="28763371"/>
    <dbReference type="InParanoid" id="A0A177CY83"/>
    <dbReference type="OrthoDB" id="3830006at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="9"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="60"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG12161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="448" mass="50487" checksum="BCA9F806AFF9BFDD" modified="2016-09-07" version="1">MSTDPPPSRGSSPYLRPRLSLSTVTSIFPRPRGNSKSPHPDRPSTGNSGGWLSPLEPSRSRSSSTSRSIRSISSKSPGKWIRHLKRSRSASINSAAGEDNLPLKREDFKEVEGWFDAFQKYNRLITNQVSGNSNFPAEELSKIQKTICEVEGGRFINDLPEALFDIALLWCPAGEMTRKSVTESSEPSWSWTAWNGAVNFPFDPSSCPDVRRRGEAPVFFKSKITSFVLGPESGCERYTIMNRAMSLKLDPISTQRPRIEYPTAGLQLLASEPPKVQSDTLRFTAQKVDASAFKMEQIYDEEKQPLLCTGLIDSQDRPCGVLMDYKKKIVAHQQDGKLHYILLSVNRRVPSTFSKSSNNISHPSGIPIWKDGRFLKEEEIGDPEDYNNDGEWKMYNVMLIQEFEAKTLDDGSFQEAFARRVAVGRIHEDAWNEAMKTVPNRFSKIVLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CYJ3</accession>
    <name>A0A177CYJ3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1159873</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042948.1">
        <property type="nucleotide sequence ID" value="XM_018177351.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CYJ3"/>
    <dbReference type="STRING" id="1460663.A0A177CYJ3"/>
    <dbReference type="GeneID" id="28760837"/>
    <dbReference type="InParanoid" id="A0A177CYJ3"/>
    <dbReference type="OrthoDB" id="5350673at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052400">
        <property type="entry name" value="Zn2-C6_fungal_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47657">
        <property type="entry name" value="STEROL REGULATORY ELEMENT-BINDING PROTEIN ECM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47657:SF7">
        <property type="entry name" value="STEROL REGULATORY ELEMENT-BINDING PROTEIN ECM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="2">
        <location>
            <begin position="18"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG12583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="530" mass="58790" checksum="5A94DE34538087D3" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CYR9</accession>
    <name>A0A177CYR9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1159975</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018043070.1">
        <property type="nucleotide sequence ID" value="XM_018177375.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CYR9"/>
    <dbReference type="GeneID" id="28760861"/>
    <dbReference type="InParanoid" id="A0A177CYR9"/>
    <dbReference type="OrthoDB" id="3833686at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG12705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="76" mass="8225" checksum="D2F9C5D2A3DE82BB" modified="2016-09-07" version="1">MSSQQDDLLASSSLRNALATFGPSSAQYIGIKYVVDEHMAKAALQSLSLGPQQGEEVQGREGSGQRMNLAFRPREN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CYY7</accession>
    <name>A0A177CYY7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">3'-phosphate/5'-hydroxy nucleic acid ligase</fullName>
            <ecNumber evidence="1">6.5.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CC84DRAFT_1254944</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a 3'-end 3'-phospho-ribonucleotide-RNA + a 5'-end dephospho-ribonucleoside-RNA + GTP = a ribonucleotidyl-ribonucleotide-RNA + GMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:68076"/>
            <dbReference type="Rhea" id="RHEA-COMP:10463"/>
            <dbReference type="Rhea" id="RHEA-COMP:13936"/>
            <dbReference type="Rhea" id="RHEA-COMP:17355"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:83062"/>
            <dbReference type="ChEBI" id="CHEBI:138284"/>
            <dbReference type="ChEBI" id="CHEBI:173118"/>
            <dbReference type="EC" id="6.5.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="10">Binds 2 manganese ions per subunit.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.8" evidence="1"/>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018043119.1">
        <property type="nucleotide sequence ID" value="XM_018184497.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CYY7"/>
    <dbReference type="STRING" id="1460663.A0A177CYY7"/>
    <dbReference type="GeneID" id="28767983"/>
    <dbReference type="InParanoid" id="A0A177CYY7"/>
    <dbReference type="OrthoDB" id="10249697at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003972">
        <property type="term" value="F:RNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0170057">
        <property type="term" value="F:RNA ligase (GTP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1860.10">
        <property type="entry name" value="tRNA-splicing ligase RtcB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001233">
        <property type="entry name" value="RtcB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036025">
        <property type="entry name" value="RtcB-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11118">
        <property type="entry name" value="RNA-SPLICING LIGASE RTCB HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11118:SF1">
        <property type="entry name" value="RNA-SPLICING LIGASE RTCB HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01139">
        <property type="entry name" value="RtcB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103365">
        <property type="entry name" value="Hypothetical protein PH1602"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 10" id="KW-0464">Manganese</keyword>
    <keyword evidence="3 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="GMP-histidine intermediate" evidence="8">
        <location>
            <position position="459"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="247"/>
            <end position="251"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="248"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="274"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="372"/>
            <end position="373"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="372"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="459"/>
            <end position="462"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR601233-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR601233-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR601233-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OAG12754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="548" mass="59187" checksum="C93863793536853E" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CZQ7</accession>
    <name>A0A177CZQ7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Very long-chain fatty acid transport protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">Very-long-chain acyl-CoA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">CC84DRAFT_1077543</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Acyl-CoA synthetase required for both the import of long chain fatty acids (LCFAs) (C14-C18) and the activation very long chain fatty acids (VLCFAs) (C20-C26) by esterification of the fatty acids into metabolically active CoA-thioesters for subsequent degradation or incorporation into phospholipids. The transport and fatty acyl-CoA synthetase activities are genetically separable and are thus independent activities. Esterifies VLCFAs in the peroxisome matrix. The VLCFAs are actively transported into peroxisomes by a PXA1-PXA2 heterodimeric transporter in the peroxisomal membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>a very long-chain fatty acid + ATP + CoA = a very long-chain fatty acyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:54536"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:58950"/>
            <dbReference type="ChEBI" id="CHEBI:138261"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Lipid droplet</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Peroxisome membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018043358.1">
        <property type="nucleotide sequence ID" value="XM_018173758.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CZQ7"/>
    <dbReference type="STRING" id="1460663.A0A177CZQ7"/>
    <dbReference type="GeneID" id="28757244"/>
    <dbReference type="InParanoid" id="A0A177CZQ7"/>
    <dbReference type="OrthoDB" id="10253869at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009898">
        <property type="term" value="C:cytoplasmic side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005324">
        <property type="term" value="F:long-chain fatty acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044539">
        <property type="term" value="P:long-chain fatty acid import into cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000002">
        <property type="entry name" value="Long-chain fatty acid transport protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12780:FF:000019">
        <property type="entry name" value="Long-chain fatty acid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43107:SF15">
        <property type="entry name" value="FATTY ACID TRANSPORT PROTEIN 3, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43107">
        <property type="entry name" value="LONG-CHAIN FATTY ACID TRANSPORT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0436">Ligase</keyword>
    <keyword evidence="8" id="KW-0551">Lipid droplet</keyword>
    <keyword evidence="13" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="20">
        <location>
            <begin position="57"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="21">
        <location>
            <begin position="491"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="22">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00051585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00060276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00068795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00078285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="OAG12993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="620" mass="69064" checksum="E066BB94D3D7DC4E" modified="2016-09-07" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CZU4</accession>
    <name>A0A177CZU4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GPN-loop GTPase</fullName>
            <ecNumber evidence="5">3.6.5.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CC84DRAFT_1077717</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Small GTPase required for proper nuclear import of RNA polymerase II (RNAPII). May act at an RNAP assembly step prior to nuclear import.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Binds to RNA polymerase II.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the GPN-loop GTPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.-" evidence="5"/>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018043181.1">
        <property type="nucleotide sequence ID" value="XM_018173768.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CZU4"/>
    <dbReference type="FunCoup" id="A0A177CZU4">
        <property type="interactions" value="863"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CZU4"/>
    <dbReference type="GeneID" id="28757254"/>
    <dbReference type="InParanoid" id="A0A177CZU4"/>
    <dbReference type="OrthoDB" id="243313at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007064">
        <property type="term" value="P:mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd17870">
        <property type="entry name" value="GPN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004130">
        <property type="entry name" value="Gpn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030230">
        <property type="entry name" value="Gpn1/Npa3/XAB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231:SF8">
        <property type="entry name" value="GPN-LOOP GTPASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231">
        <property type="entry name" value="XPA-BINDING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03029">
        <property type="entry name" value="ATP_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="324"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="324"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="366"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU365059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAG12816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="432" mass="47561" checksum="216B59D231F26ABD" modified="2016-09-07" version="1">MSGAAPSSEAPVAIVCVGMAGSGKTTFMQRLVSHLYTHADPTQSEPATSKTPAAPPYILNLDPAVHYVPFTPNIDIRDSVNYKEVMKQFNLGPNGGILTSLNLFSTKIDQVISLLEKRTAPPEPAEQPEQTTVEFMTNSGKTTPPAQKPPHVKHILVDTPGQIEVFVWSASGEILLSSLASTFPTVIAYVIDTPRTTSTSTFMSNMLYACSILYKTKLPMILVFNKTDAQDAQFAKDWMTDFEAFQSALRNEEEGGSFGGEGSAIGGGSGYMGSLLNSMSLVFEEFYKHLSVVGVSSMTGDGMDEFFRSVQVKKDEFERDYKPELERRRAEREQEKATTRQKELDKLMKDMNVGGASKGKKKMDEPETVSDVEDNSDEGMQVDDDDSEDEEYDSDNPEHGLKARYQQALRDDAGPSAEDFSFARYVHKANLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177D013</accession>
    <name>A0A177D013_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DUF862-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CC84DRAFT_1110099</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DeSI family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG13064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018043429.1">
        <property type="nucleotide sequence ID" value="XM_018175240.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177D013"/>
    <dbReference type="STRING" id="1460663.A0A177D013"/>
    <dbReference type="GeneID" id="28758726"/>
    <dbReference type="InParanoid" id="A0A177D013"/>
    <dbReference type="OrthoDB" id="412286at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0101005">
        <property type="term" value="F:deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1720.30">
        <property type="entry name" value="PPPDE domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008580">
        <property type="entry name" value="PPPDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042266">
        <property type="entry name" value="PPPDE_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12378">
        <property type="entry name" value="DESUMOYLATING ISOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12378:SF80">
        <property type="entry name" value="IP06716P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05903">
        <property type="entry name" value="Peptidase_C97"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01179">
        <property type="entry name" value="DUF862"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51858">
        <property type="entry name" value="PPPDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPPDE" evidence="5">
        <location>
            <begin position="26"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="200"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="178"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAG13064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="253" mass="28216" checksum="44FE7CEB1E0BF031" modified="2016-09-07" version="1" fragment="single">MSSSTRPKPTRKSSSNHRNTLSLQKTEIKIHIYDLLPPGKVSTMLWAIGSSLLHSGVVIGDREYAYGGHDQRGLSGVYYTKPGQEPPGGTFRQALLHGFSFRPQEELDAIIHEASQQFMGTSYNLLTKNCNHFTSYLCDKLTGRSAPSWLNRAASIGVALPCVVPREWISPPDHDTADGELLDEDFEDERSSMLRHDERRRRLRATEDDAQDWEDAQTERISGASGGSDQRGPRGHPRAIPAAERAPLPRRIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177D0A5</accession>
    <name>A0A177D0A5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cloroperoxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CC84DRAFT_1192758</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the chloroperoxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018043022.1">
        <property type="nucleotide sequence ID" value="XM_018181257.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177D0A5"/>
    <dbReference type="GeneID" id="28764743"/>
    <dbReference type="InParanoid" id="A0A177D0A5"/>
    <dbReference type="OrthoDB" id="407298at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.489.10">
        <property type="entry name" value="Chloroperoxidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000028">
        <property type="entry name" value="Chloroperoxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036851">
        <property type="entry name" value="Chloroperoxidase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33577:SF15">
        <property type="entry name" value="HEME HALOPEROXIDASE FAMILY PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33577">
        <property type="entry name" value="STERIGMATOCYSTIN BIOSYNTHESIS PEROXIDASE STCC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01328">
        <property type="entry name" value="Peroxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47571">
        <property type="entry name" value="Cloroperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51405">
        <property type="entry name" value="HEME_HALOPEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 10" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008058826" evidence="8">
        <location>
            <begin position="18"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="domain" description="Heme haloperoxidase family profile" evidence="9">
        <location>
            <begin position="94"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAG12657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="428" mass="46036" checksum="2E7691AA7A7CAA63" modified="2016-09-07" version="1">MTCYFLSSIYLASAVSAWPWIANVPGVDLSAIHNHPENFAKQHRQTGSLDPTCPFNADHPGAAPFDVRFPYTGSINGLPGTGIGGVQVPAPGDTAHEFTPPGPNDIRGPCPGMNTAANHNFLSHDGITDLAELVSAQQNLYNLAYDLAVFIAVRGIALDGDVVTTKLSIGCDATERTSIDPTGTLGREPGLNAHNKFEGDTSLTRRDYFLNNGDAFTFQGDMFADMYRVANGTSNGLFDRDTIAVYRSQRYDESLAENPNFYFGPKALLLYGAASFIYEVFPIFGPEGDANIDMISTFYGAVPNSAGSYDHVPERIPENWSNRRTAYGLLEIGEEIRYQFSYAPKLFGGNVGAGNFLALNTTFGIIENGTIPGDATAADFTCLLYQLATDNVPGTVGNEAALPLDVLAWVLTQLNPVFGNLGCPLKLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177D0D7</accession>
    <name>A0A177D0D7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1160111</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018043223.1">
        <property type="nucleotide sequence ID" value="XM_018177410.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177D0D7"/>
    <dbReference type="STRING" id="1460663.A0A177D0D7"/>
    <dbReference type="GeneID" id="28760896"/>
    <dbReference type="InParanoid" id="A0A177D0D7"/>
    <dbReference type="OrthoDB" id="690068at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46266">
        <property type="entry name" value="TRANSCRIPTION FACTOR TT8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46266:SF4">
        <property type="entry name" value="TRANSCRIPTION FACTOR TT8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BHLH" evidence="2">
        <location>
            <begin position="171"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="232"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="311"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="363"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="60"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="132"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="259"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="328"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="370"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="433"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG12858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="451" mass="47308" checksum="07A6D9EB2035FD00" modified="2016-09-07" version="1">MSAPAGQRPIMPRPSFPPTPAPSTDITGKTSALAGPLDTTHFALPPAAIGSARGSTTEPSSTASNASDSSYRPLSPASPSATSKPPPASRKRPSSSQSVVTKDDYSLPPPPTRSRKIIQMKPKESQEQPKTAASPASAAKSAPAGGAGAAGAAGGKRKQSGNTTAAGRKIARKTAHSLIERRRRSKMNEEFGVLKDMIPACEGQEMHKLAILQASIEYMRYLQQCVDDLKAAHRPRRASPTPASPQQERSPLAVATAAAEEDDDDDEDEDEEDDQDEEMSDAVSPKHTAHGPRTANYQFANASPAIYPSDRSVYSTTTSPALRPGDVQNYSANMSPALQPSDPHHYSLSSSIRSTATSPLIQASPAFGGQTPSQAQFQNPFPTAPSSKNSLSGPAGGFALTSPALGPQADREDHEATEALLMLNTDRRSWHGSNGGQGGGRGMSVRDLLTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177D0L5</accession>
    <name>A0A177D0L5_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidase S9 prolyl oligopeptidase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1160233</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018043356.1">
        <property type="nucleotide sequence ID" value="XM_018177448.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177D0L5"/>
    <dbReference type="STRING" id="1460663.A0A177D0L5"/>
    <dbReference type="GeneID" id="28760934"/>
    <dbReference type="InParanoid" id="A0A177D0L5"/>
    <dbReference type="OrthoDB" id="2425929at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050955">
        <property type="entry name" value="Plant_Biomass_Hydrol_Est"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43037:SF3">
        <property type="entry name" value="FERULOYL ESTERASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43037">
        <property type="entry name" value="UNNAMED PRODUCT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Peptidase S9 prolyl oligopeptidase catalytic" evidence="2">
        <location>
            <begin position="2"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG12991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="184" mass="19570" checksum="7A32D934D21E6828" modified="2016-09-07" version="1">MVKYAVDKYGGDSEKVFVTGSSSGAMMTQVMAGAYPDVFKAASAYSGVPDGCFFVQGATATQDPPGWNNACANGQTTKTAQQWGDATRGYFPGYNGTRPRMLIWHGTADNTLRYPNYQESLKQWSNVLGLTTSKTASNTPQSGYTQTIYGDGDSNTAKLVGYSGQGVGHTVPVHESADIAFFGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177D1I3</accession>
    <name>A0A177D1I3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Elongation factor 1 beta subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_1136283</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the EF-1-beta/EF-1-delta family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG13032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018043397.1">
        <property type="nucleotide sequence ID" value="XM_018176092.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177D1I3"/>
    <dbReference type="FunCoup" id="A0A177D1I3">
        <property type="interactions" value="769"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177D1I3"/>
    <dbReference type="GeneID" id="28759578"/>
    <dbReference type="InParanoid" id="A0A177D1I3"/>
    <dbReference type="OrthoDB" id="331763at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005853">
        <property type="term" value="C:eukaryotic translation elongation factor 1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00292">
        <property type="entry name" value="EF1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.60:FF:000001">
        <property type="entry name" value="Elongation factor 1-beta 1 like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036219">
        <property type="entry name" value="eEF-1beta-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018940">
        <property type="entry name" value="EF-1_beta_acid_region_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049720">
        <property type="entry name" value="EF1B_bsu/dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014038">
        <property type="entry name" value="EF1B_bsu/dsu_GNE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014717">
        <property type="entry name" value="Transl_elong_EF1B/ribsomal_bS6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001326">
        <property type="entry name" value="Transl_elong_EF1B_B/D_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11595">
        <property type="entry name" value="EF-HAND AND COILED-COIL DOMAIN-CONTAINING FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11595:SF21">
        <property type="entry name" value="ELONGATION FACTOR 1-BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10587">
        <property type="entry name" value="EF-1_beta_acid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00736">
        <property type="entry name" value="EF1_GNE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01182">
        <property type="entry name" value="EF-1_beta_acid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00888">
        <property type="entry name" value="EF1_GNE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54984">
        <property type="entry name" value="eEF-1beta-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00824">
        <property type="entry name" value="EF1BD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00825">
        <property type="entry name" value="EF1BD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="3 4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Elongation factor 1 beta central acidic region eukaryote" evidence="7">
        <location>
            <begin position="109"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="Translation elongation factor EF1B beta/delta subunit guanine nucleotide exchange" evidence="6">
        <location>
            <begin position="144"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="73"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAG13032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="230" mass="25770" checksum="AABEDFB4F8F8C384" modified="2016-09-07" version="1">MGFSDLVSDAGLTILNNWVKTRSYIVGYTPSQADVKVFQQLKTVPAPEKYPFAWRWYNHILTWESEFSSLPGDPTKDHTAYGPEQTELPVNPAKAPEAAAEEDDDEVDLFGSDDEVDEEAEKLKAERLAEYNKKKAGKVKPAAKSIVTMDVKPWDDETNLDELKANVLAIEKDGLVWGASQFVAVGFGIKKLQINLVVEDEKVSLDELQQQIEEDEDHVQSTDIIAMQKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BT49</accession>
    <name>A0A177BT49_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1234294</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441566">
        <property type="protein sequence ID" value="OAF98563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018028929.1">
        <property type="nucleotide sequence ID" value="XM_018183810.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BT49"/>
    <dbReference type="GeneID" id="28767296"/>
    <dbReference type="InParanoid" id="A0A177BT49"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAF98563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="228" mass="26124" checksum="563C1E18A6411818" modified="2016-09-07" version="1">MWYWQDPVPSKTYALETRFEPQVARGPNVAKSMINRRYACFAEFGSADIVSRLSDEMLELPLNESDAVEDIAEDYRRGISIVIFPHHFGSRDNIVGTILHHIDHEQDAGPAVSHHRRPDFGLQSISSSAQQWSDANPDVTTDEAHAAPRRRGVRRTCAFHRRPSNRRSNTVRWNRPNRTPPRHISELRASAQTSHRILSEAYRPECARQCSRRGPPFEQLLHDTAKGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2023-06-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BTV5</accession>
    <name>A0A177BTV5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1106008</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441566">
        <property type="protein sequence ID" value="OAF98605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018028971.1">
        <property type="nucleotide sequence ID" value="XM_018175120.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BTV5"/>
    <dbReference type="GeneID" id="28758606"/>
    <dbReference type="InParanoid" id="A0A177BTV5"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAF98605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="63" mass="7693" checksum="A5EB096F3C82D9BA" modified="2016-09-07" version="1" fragment="single">RTISHLSAHTQLVQLENEDLRNVIRELKPSKNKWRRLDLQHRKEFHSTAVLWVPRKIRQAEER</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BUJ0</accession>
    <name>A0A177BUJ0_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_1170006</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the isochorismatase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441565">
        <property type="protein sequence ID" value="OAF98640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029006.1">
        <property type="nucleotide sequence ID" value="XM_018179808.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BUJ0"/>
    <dbReference type="STRING" id="1460663.A0A177BUJ0"/>
    <dbReference type="GeneID" id="28763294"/>
    <dbReference type="InParanoid" id="A0A177BUJ0"/>
    <dbReference type="OrthoDB" id="445341at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006307">
        <property type="term" value="P:DNA alkylation repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00431">
        <property type="entry name" value="cysteine_hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.590">
        <property type="entry name" value="Alpha-ketoglutarate-dependent dioxygenase AlkB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="entry name" value="Isochorismatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027450">
        <property type="entry name" value="AlkB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037151">
        <property type="entry name" value="AlkB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032854">
        <property type="entry name" value="ALKBH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31212">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE ALKB HOMOLOG 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31212:SF5">
        <property type="entry name" value="ISOCHORISMATASE FAMILY PROTEIN FAMILY (AFU_ORTHOLOGUE AFUA_3G14500)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13532">
        <property type="entry name" value="2OG-FeII_Oxy_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="Isochorismatase-like hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="3">
        <location>
            <begin position="682"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="97"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="317"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="390"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="317"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="369"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="413"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="452"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="482"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="499"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAF98640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="1071" mass="120946" checksum="8D4002B9E949A57B" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BUU5</accession>
    <name>A0A177BUU5_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ubiquitin 3 binding protein But2 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_388945</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441562">
        <property type="protein sequence ID" value="OAF99243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029609.1">
        <property type="nucleotide sequence ID" value="XM_018186006.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BUU5"/>
    <dbReference type="GeneID" id="28769492"/>
    <dbReference type="InParanoid" id="A0A177BUU5"/>
    <dbReference type="OrthoDB" id="3772810at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008057344" description="Ubiquitin 3 binding protein But2 C-terminal domain-containing protein" evidence="1">
        <location>
            <begin position="24"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAF99243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="245" mass="26250" checksum="099B95D21369E136" modified="2016-09-07" version="1">MLSLHTLANLIVTSFLLAPPTTALPLWPNNTTPAAVPTACSSPTSNPTAEIAPACQSFYPTSYRIMNSRYPTWDQTPLHGNQDFVMLLRQRADTFQVATQVQFDGLGDVAPPNSSSTCRLQFQLPAKDMQTVLGPAPVVDVYQVEREAGSPASWSTYEPALAASSNGSVSAPRLFGSINGSLAAQETAWNQSVGLVDVGATFCNATLTWQMAMAIDGGDEVNYWDFIGVDPPFNPVQGFRVITGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BUW1</accession>
    <name>A0A177BUW1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1157747</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441563">
        <property type="protein sequence ID" value="OAF98935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029301.1">
        <property type="nucleotide sequence ID" value="XM_018177029.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BUW1"/>
    <dbReference type="STRING" id="1460663.A0A177BUW1"/>
    <dbReference type="GeneID" id="28760515"/>
    <dbReference type="InParanoid" id="A0A177BUW1"/>
    <dbReference type="OrthoDB" id="19653at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF3">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="2">
        <location>
            <begin position="48"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAF98935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="313" mass="34480" checksum="72C7CD6B6CD4B6C2" modified="2016-09-07" version="1">MSLRTTAENRFDTFKLYTTSYKKIGDHEIEVNVLVPKDIKPGKRPIMIKWHGGGLTAGTAVYPPWFAGYLVPFLHRNNAIAILPNYRLAPEHTGDEILSDVADLGAWLTDSLPAYLASKEPAISPDLSKILVSGESAGGWVALQSVLSLSEGTFKACLLQYPVLNAFPTYPDDIIMGDPIPPKEVLDEFLTGIVPGTIISAARPPLRNAVAPMLRAHGRWGEFFGTGKHLMPDTRIEDAQFWVPTYILHGRDDTNVAVEWSEKFVGRARSLFPETKIELATPPGEHGFDGDLYEEDAGWLADLLKGVEGEWLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BV45</accession>
    <name>A0A177BV45_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1210780</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441568">
        <property type="protein sequence ID" value="OAF98528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018028894.1">
        <property type="nucleotide sequence ID" value="XM_018182315.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BV45"/>
    <dbReference type="GeneID" id="28765801"/>
    <dbReference type="InParanoid" id="A0A177BV45"/>
    <dbReference type="OrthoDB" id="10566960at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="200"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="335"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="419"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="528"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="241"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="335"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="369"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAF98528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="586" mass="64982" checksum="9CE46E5A3C316C76" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BVH9</accession>
    <name>A0A177BVH9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1264730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441564">
        <property type="protein sequence ID" value="OAF98731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029097.1">
        <property type="nucleotide sequence ID" value="XM_018185331.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BVH9"/>
    <dbReference type="GeneID" id="28768817"/>
    <dbReference type="InParanoid" id="A0A177BVH9"/>
    <dbReference type="OrthoDB" id="6365676at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.30">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036361">
        <property type="entry name" value="SAP_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="313"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="243"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="254"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="326"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="369"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="405"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="452"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="486"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="508"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="539"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="561"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="613"/>
            <end position="622"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAF98731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="674" mass="72975" checksum="550DB53DBE3DE1B3" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2023-06-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BVJ6</accession>
    <name>A0A177BVJ6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_407450</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441562">
        <property type="protein sequence ID" value="OAF99503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029869.1">
        <property type="nucleotide sequence ID" value="XM_018186074.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BVJ6"/>
    <dbReference type="GeneID" id="28769560"/>
    <dbReference type="InParanoid" id="A0A177BVJ6"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAF99503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="159" mass="17901" checksum="E8075BBD1A166792" modified="2016-09-07" version="1">MPCNATRPRSRLHIHHHFSLSSVCLFLHGVLPARVGMIEHLFFSHVLRRLLHVAALPRVAFLRRSTYWVPVGATIPFRFLSSSVRVMSCYLQNSLLLFTRKLLSRILRTQYGSVLHGRCLNESGYDIPRLVGPSLHMASNSVSIPSVVVCPVEGGENFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BVW4</accession>
    <name>A0A177BVW4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_1048333</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441561">
        <property type="protein sequence ID" value="OAF99552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029918.1">
        <property type="nucleotide sequence ID" value="XM_018173438.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BVW4"/>
    <dbReference type="GeneID" id="28756924"/>
    <dbReference type="InParanoid" id="A0A177BVW4"/>
    <dbReference type="OrthoDB" id="10021397at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF187">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAF99552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="62" mass="6195" checksum="7FC79B8F50BC9D75" modified="2016-09-07" version="1" fragment="single">SAAVQPLFGQPCNNFGRCWRMLGATALFTLGSGICGGAVNSSMLIAGRGIQCAGSGGMVMIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BWU0</accession>
    <name>A0A177BWU0_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CC84DRAFT_1050737</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441563">
        <property type="protein sequence ID" value="OAF98977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029343.1">
        <property type="nucleotide sequence ID" value="XM_018173471.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BWU0"/>
    <dbReference type="STRING" id="1460663.A0A177BWU0"/>
    <dbReference type="GeneID" id="28756957"/>
    <dbReference type="InParanoid" id="A0A177BWU0"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16473">
        <property type="entry name" value="RING-H2_RNF103"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000539">
        <property type="entry name" value="Ring finger domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051826">
        <property type="entry name" value="E3_ubiquitin-ligase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22765:SF434">
        <property type="entry name" value="GB|AAD18119.1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22765">
        <property type="entry name" value="RING FINGER AND PROTEASE ASSOCIATED DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="21"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="4">
        <location>
            <begin position="243"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="102"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="291"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="138"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="165"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="177"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="300"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="343"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="372"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAF98977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="437" mass="46788" checksum="4839862EDD210BD4" modified="2016-09-07" version="1" fragment="single">PSQTSGGGGGGGGGGPTSSPLLFFVALGFGVVFTNLWIIVGVKYCFRYNQRNRAARAAADGEPIDLTAMPRPHRRRREKKLMTMDEVNERFPLQKYKQWKASRENQGLPASGGIATAPQSRANSVKDVDGVVAPMQEGASSPSPATSLSKAQEGHAATSGALQKETMSPRTSLSAGENKETGSEKKEVDEKHAELVQTETAVSHYEPSKPSQAHEHDGEDSDDDDPIRTAAAPELLTEPGDTCAICLDTLEDQDDVRGLTCGHAFHASCVDPWLTSRRACCPLCKADYYVPKPRPEGETQEQTASGRRSNATGLRSPTTPPATWNARGNPFSRSRVVAISGPGRQNGSNTRQGNSGMPMMDLFNRPRRQDRTAPTTTDATAPVSEPRPTMSSWRARLGRPVVPTGSMPGWWGRGRGADADNSASAQPTPGQLEAGNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BWX6</accession>
    <name>A0A177BWX6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1222823</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441561">
        <property type="protein sequence ID" value="OAF99814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030180.1">
        <property type="nucleotide sequence ID" value="XM_018183421.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BWX6"/>
    <dbReference type="GeneID" id="28766907"/>
    <dbReference type="InParanoid" id="A0A177BWX6"/>
    <dbReference type="OrthoDB" id="3944237at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAF99814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="105" mass="12287" checksum="6DAF4504F364F6F7" modified="2016-09-07" version="1">MWVDPMLLTNTKSHKRQKQSSQMEDYFDSLLEDLQLADERMSKLLDDPHPVIEACQRQKNWLRRNTVLSYFKDLTEYIDGRDLSFLAVDEAPDDDDLDAQPTPPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BX41</accession>
    <name>A0A177BX41_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CC84DRAFT_1222316</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441560">
        <property type="protein sequence ID" value="OAF99982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030348.1">
        <property type="nucleotide sequence ID" value="XM_018183355.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BX41"/>
    <dbReference type="GeneID" id="28766841"/>
    <dbReference type="InParanoid" id="A0A177BX41"/>
    <dbReference type="OrthoDB" id="444631at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF47">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="22"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="59"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="100"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="139"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="194"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="227"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="260"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="44"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="306"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="367"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="306"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="398"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAF99982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="422" mass="47433" checksum="2AB3F1C74F2AAC38" modified="2016-09-07" version="1">MASPLRSPPLGVASVFGQSGSLALPAIATACACLPLIFFCALSRILSRVLARKWSFQDYLFCFTLVISIAFIAYSIPLTLAEPFGYHVWDIDTRHLTKPWMLRFLTFAIFTGPVLWFSKTMVIAHLVHVFTSVRWFKNTGYIIVVATGMIYGLYTCTTSIACSPKPDDDLDSYINGFRQRTCSGRGGANMAVGMLMALINSLADFYLLIATFVLSPSMNVTVKERRVIWLMHFVGIVASVCSILGLVYRIKAFQDADLTGYQIPIIVALILEVSISLMIPCMSSFYQIYRHYTYVEINERTTIGTPSPRYQSSLSYYKSPSHTNPSTPTPDPKTSWRKTHMSVEELPFRRASAEFYRKSPLALHDVRDSRMKRLPPTPLPMASRNNSVAERIEGSKGPKTPKTPKTPNSARSMRLPILFERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BXN3</accession>
    <name>A0A177BXN3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1168955</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441560">
        <property type="protein sequence ID" value="OAG00075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030440.1">
        <property type="nucleotide sequence ID" value="XM_018179540.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BXN3"/>
    <dbReference type="GeneID" id="28763026"/>
    <dbReference type="InParanoid" id="A0A177BXN3"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG00075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="140" mass="15477" checksum="4EF9907EBCD401E3" modified="2016-09-07" version="1">MERIHRGSSCRTESLWPCRRFRCDRFSHICHTEWSSALGFDVGHDPRVGRTDDSGPSNDSDFDRTSTLDAFDSAYTSDLDAAYYVALFPVAYLGCIGWAVLENCLYPDCSFADPGYVHLGLVLGPVLVSPWLSTLSIGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BXQ4</accession>
    <name>A0A177BXQ4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">TAFII55 protein conserved region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_1200301</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF7 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441563">
        <property type="protein sequence ID" value="OAF99109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029475.1">
        <property type="nucleotide sequence ID" value="XM_018181656.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BXQ4"/>
    <dbReference type="STRING" id="1460663.A0A177BXQ4"/>
    <dbReference type="GeneID" id="28765142"/>
    <dbReference type="InParanoid" id="A0A177BXQ4"/>
    <dbReference type="OrthoDB" id="153872at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08047">
        <property type="entry name" value="TAF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037817">
        <property type="entry name" value="TAF7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006751">
        <property type="entry name" value="TAFII55_prot_cons_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12228:SF0">
        <property type="entry name" value="TATA-BOX BINDING PROTEIN ASSOCIATED FACTOR 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12228">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID 55 KD SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04658">
        <property type="entry name" value="TAFII55_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01370">
        <property type="entry name" value="TAFII55_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TAFII55 protein conserved region" evidence="7">
        <location>
            <begin position="186"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="143"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="343"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="454"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="26"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="83"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="355"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="458"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="469"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAF99109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="559" mass="61558" checksum="8CD9F45BC7153DEA" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BY56</accession>
    <name>A0A177BY56_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DnaJ-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_1130457</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441561">
        <property type="protein sequence ID" value="OAF99618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029984.1">
        <property type="nucleotide sequence ID" value="XM_018175860.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BY56"/>
    <dbReference type="FunCoup" id="A0A177BY56">
        <property type="interactions" value="884"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177BY56"/>
    <dbReference type="GeneID" id="28759346"/>
    <dbReference type="InParanoid" id="A0A177BY56"/>
    <dbReference type="OrthoDB" id="5894at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051964">
        <property type="entry name" value="Chaperone_stress_response"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022755">
        <property type="entry name" value="Znf_C2H2_jaz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054076">
        <property type="entry name" value="ZUO1-like_ZHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44029">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44029:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12171">
        <property type="entry name" value="zf-C2H2_jaz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21884">
        <property type="entry name" value="ZUO1-like_ZHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="J" evidence="6">
        <location>
            <begin position="21"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="314"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="249"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="355"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="530"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="256"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="374"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="411"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAF99618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="553" mass="61570" checksum="7CF14C55F97407DA" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BY92</accession>
    <name>A0A177BY92_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Autophagy-related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CC84DRAFT_1169188</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Vacuolar effluxer which mediate the efflux of amino acids resulting from autophagic degradation. The release of autophagic amino acids allows the maintenance of protein synthesis and viability during nitrogen starvation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Vacuole membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the ATG22 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441561">
        <property type="protein sequence ID" value="OAF99661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030027.1">
        <property type="nucleotide sequence ID" value="XM_018179591.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BY92"/>
    <dbReference type="FunCoup" id="A0A177BY92">
        <property type="interactions" value="27"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177BY92"/>
    <dbReference type="GeneID" id="28763077"/>
    <dbReference type="InParanoid" id="A0A177BY92"/>
    <dbReference type="OrthoDB" id="192733at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032974">
        <property type="term" value="P:amino acid transmembrane export from vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17483">
        <property type="entry name" value="MFS_Atg22_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044738">
        <property type="entry name" value="Atg22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024671">
        <property type="entry name" value="Atg22-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050495">
        <property type="entry name" value="ATG22/LtaA_families"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23519">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23519:SF1">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11700">
        <property type="entry name" value="ATG22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="8 10" id="KW-0072">Autophagy</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <keyword evidence="4 10" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="73"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="150"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="182"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="206"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="323"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="352"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="419"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="450"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="488"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="527"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="558"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="589"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="620"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="21"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="34"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="49"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OAF99661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="653" mass="71741" checksum="8ECB3611C1CD9ECD" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2023-06-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BZ26</accession>
    <name>A0A177BZ26_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1169051</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441560">
        <property type="protein sequence ID" value="OAG00221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030586.1">
        <property type="nucleotide sequence ID" value="XM_018179557.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BZ26"/>
    <dbReference type="GeneID" id="28763043"/>
    <dbReference type="InParanoid" id="A0A177BZ26"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG00221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="62" mass="7005" checksum="719FFB00D2A42388" modified="2016-09-07" version="1">MELPLPKLSFSWSHRTLRIQAMKNFPQIPQIQMVLRATQVAWRDVQNVGGACSSAVSMPPVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BZA3</accession>
    <name>A0A177BZA3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1222256</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441560">
        <property type="protein sequence ID" value="OAF99911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030277.1">
        <property type="nucleotide sequence ID" value="XM_018183347.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BZA3"/>
    <dbReference type="GeneID" id="28766833"/>
    <dbReference type="InParanoid" id="A0A177BZA3"/>
    <dbReference type="OrthoDB" id="10039103at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020100">
        <property type="entry name" value="Glc-repressible_Grg1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11034">
        <property type="entry name" value="Grg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAF99911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="87" mass="9239" checksum="BD5D56D69AB26CA3" modified="2016-09-07" version="1">MSSNTNAQGEGFVESTINTVKDNVNWAANKVTGNTEEAQRKANQEQAKHGNSVGDKLDGALGTVKHGANEATDKSKAQYYDGKSSTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C022</accession>
    <name>A0A177C022_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Lactose permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CC84DRAFT_1222469</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441560">
        <property type="protein sequence ID" value="OAG00158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030523.1">
        <property type="nucleotide sequence ID" value="XM_018183375.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C022"/>
    <dbReference type="GeneID" id="28766861"/>
    <dbReference type="InParanoid" id="A0A177C022"/>
    <dbReference type="OrthoDB" id="6133115at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000134">
        <property type="entry name" value="MFS sugar transporter protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF70">
        <property type="entry name" value="MONOSACCHARIDE TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G14540)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50244">
        <property type="entry name" value="S5A_REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="128"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="153"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="188"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="222"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="319"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="351"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="381"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="415"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="453"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="478"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="59"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAG00158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="550" mass="61019" checksum="382EE284225BFD51" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C098</accession>
    <name>A0A177C098_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">FAR-17a/AIG1-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CC84DRAFT_1168435</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441559">
        <property type="protein sequence ID" value="OAG00319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030684.1">
        <property type="nucleotide sequence ID" value="XM_018179394.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C098"/>
    <dbReference type="STRING" id="1460663.A0A177C098"/>
    <dbReference type="GeneID" id="28762880"/>
    <dbReference type="InParanoid" id="A0A177C098"/>
    <dbReference type="OrthoDB" id="1898221at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006838">
        <property type="entry name" value="ADTRP_AIG1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10989">
        <property type="entry name" value="ANDROGEN-INDUCED PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10989:SF16">
        <property type="entry name" value="AT02829P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04750">
        <property type="entry name" value="Far-17a_AIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="166"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="209"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAG00319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="251" mass="28136" checksum="442264F29E9D8C48" modified="2016-09-07" version="1">MSAFRVADELKRRHPLQRLDAPSKGISGAAHVIGLVSFYRSFKFLVDNPNIINYSFGWHLQYLTVLGLSISTTCFTIGLLADMTSSQQLFTLKNYLALVAAPIEIIISMLYWGLRAIDRELVIPPDLPTPPVMADLGFHLFPTLLLSLDALFLSPPWPTSPINPRASTLSLMISTAIAFLYWFWIELCHSRNGFYPYPIFALLNTTQRIGLFALSGVAMWAAGAGLRWCYRVVNGIERDTVIEHGEDKKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C3P6</accession>
    <name>A0A177C3P6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1179571</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441557">
        <property type="protein sequence ID" value="OAG01502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031867.1">
        <property type="nucleotide sequence ID" value="XM_018180424.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C3P6"/>
    <dbReference type="GeneID" id="28763910"/>
    <dbReference type="InParanoid" id="A0A177C3P6"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG01502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="157" mass="16721" checksum="DC1A1F053A682C11" modified="2016-09-07" version="1">MVTSDANRRPASRCRMLIAAGQTASSTRAPDDGLAMAHERRATSRRKVPFGHVNSATAQGEGSQALARFRCVVGLLLWPLGACRNPSPMRRGRKKQRTRGTRRVEEVKGAAQPMGVLLSGRGTVGDALRLDLSKNKRRKSVVAGGGRLDMGATGTSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C4J4</accession>
    <name>A0A177C4J4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7165 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1152700</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441556">
        <property type="protein sequence ID" value="OAG02336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032701.1">
        <property type="nucleotide sequence ID" value="XM_018176814.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C4J4"/>
    <dbReference type="STRING" id="1460663.A0A177C4J4"/>
    <dbReference type="GeneID" id="28760300"/>
    <dbReference type="InParanoid" id="A0A177C4J4"/>
    <dbReference type="OrthoDB" id="3925024at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055589">
        <property type="entry name" value="DUF7165"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23749">
        <property type="entry name" value="DUF7165"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7165" evidence="2">
        <location>
            <begin position="96"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="482"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="527"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="653"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="817"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="60"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="535"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="556"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="709"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="745"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="780"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="911"/>
            <end position="921"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG02336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="921" mass="99887" checksum="C45577F16272F1D0" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C4V4</accession>
    <name>A0A177C4V4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">protein disulfide-isomerase</fullName>
            <ecNumber evidence="3">5.3.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CC84DRAFT_1124655</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 14">
            <text>Catalyzes the rearrangement of -S-S- bonds in proteins.</text>
            <dbReference type="EC" id="5.3.4.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the protein disulfide isomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.3.4.1" evidence="3"/>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG02764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033129.1">
        <property type="nucleotide sequence ID" value="XM_018175699.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C4V4"/>
    <dbReference type="STRING" id="1460663.A0A177C4V4"/>
    <dbReference type="GeneID" id="28759185"/>
    <dbReference type="InParanoid" id="A0A177C4V4"/>
    <dbReference type="OrthoDB" id="10264505at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003756">
        <property type="term" value="F:protein disulfide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00238">
        <property type="entry name" value="ERp29c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02998">
        <property type="entry name" value="PDI_a_ERp38"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000032">
        <property type="entry name" value="Protein disulfide-isomerase A6 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1150.12">
        <property type="entry name" value="Endoplasmic reticulum resident protein 29, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011679">
        <property type="entry name" value="ERp29_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036356">
        <property type="entry name" value="ERp29_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051063">
        <property type="entry name" value="PDI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005788">
        <property type="entry name" value="PDI_thioredoxin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01126">
        <property type="entry name" value="pdi_dom"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45672:SF11">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE C17H9.14C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45672">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE C17H9.14C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07749">
        <property type="entry name" value="ERp29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00421">
        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47933">
        <property type="entry name" value="ERP29 C domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008057729" description="protein disulfide-isomerase" evidence="10">
        <location>
            <begin position="21"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="11">
        <location>
            <begin position="8"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="11">
        <location>
            <begin position="134"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OAG02764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="364" mass="39870" checksum="53156DB64AE1CBD8" modified="2016-09-07" version="1">MLFNRLLPAALALLPALVAAENVVELTPDNFDDIVLKSGKPALVEFFAPWCGHCKNLAPVYEELATNYLHAKDKVTIAKVDADAHKSLGKKFGVQGFPTLKWFDGKSDTPKEYDSGRDLDSLAKFVQEKSGVRAKVKAKLPSQVVILDDKSFTEKVGKDQDVLVAFTAPWCGHCKNLKPVWEQLANTFANEQGVTIAQVDAEAENSKALAKEQGVSSYPTIKYFKKGTTEPLPYEGARAEADFVEFLNTNAGTYRAVGGGLNAIGGTIEALDSIVTKSKGAYASGLEEARKAAETLKDKYAQYYVKVFEKSSKNEGYAEKEYKRLQGLIGKGNLAAEKLDDLISRSNILRRFLPTGDEDEKSEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C4Z1</accession>
    <name>A0A177C4Z1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DASH complex subunit DAM1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Outer kinetochore protein DAM1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CC84DRAFT_898693</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Centromere</location>
            <location evidence="3">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DASH complex DAM1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG02585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032950.1">
        <property type="nucleotide sequence ID" value="XM_018187837.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C4Z1"/>
    <dbReference type="STRING" id="1460663.A0A177C4Z1"/>
    <dbReference type="GeneID" id="28771323"/>
    <dbReference type="InParanoid" id="A0A177C4Z1"/>
    <dbReference type="OrthoDB" id="5586015at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042729">
        <property type="term" value="C:DASH complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990537">
        <property type="term" value="C:mitotic spindle polar microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990758">
        <property type="term" value="P:mitotic sister chromatid biorientation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013962">
        <property type="entry name" value="DASH_Dam1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28113">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DAM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28113:SF1">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DAM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08653">
        <property type="entry name" value="DASH_Dam1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0137">Centromere</keyword>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="9" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="8" id="KW-0493">Microtubule</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="157"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="10"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="157"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="15">
        <location>
            <begin position="187"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00030453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OAG02585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="229" mass="24517" checksum="55E90D962F1DF0B4" modified="2016-09-07" version="1">MASTTPLAEPRSTSRTPRPRSKSPGSRLSRPTTPLRPSSRSSFRSSVSRGRAPYTSSTNPLEDLQDGFAELSDAMADLEQNFVHLQLMHESLARFSESFASFLYGLNMNAFCVDFPEAPIPDSFKRPLHDPQTNFRTSQNQEVPDVEATFLTTDTSFVENPPSSKVANKFQNPITPAPAEKKAATRGRGGIPRAGARGGGIPVRGGAGRGTRGSGIARGRGAGRGTRGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C500</accession>
    <name>A0A177C500_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1178935</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441556">
        <property type="protein sequence ID" value="OAG01959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032324.1">
        <property type="nucleotide sequence ID" value="XM_018180374.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C500"/>
    <dbReference type="GeneID" id="28763860"/>
    <dbReference type="InParanoid" id="A0A177C500"/>
    <dbReference type="OrthoDB" id="3800963at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG01959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="442" mass="50623" checksum="05784CF5BE0FBB66" modified="2016-09-07" version="1">MASLIKRIRLNQLPCKIPNSPSMVAASSPFGMSKAALERRMHNQIPRKRHTPYTAAKSAARPTPKHVVRPFPKRNTGSDSKNPSASRGRKSKPEKRGTNRTRIVGTSGDRISQWSARRILASRQHPFNPSKTLYKVQWKTTWEDASEVNGLVAAEWREALNEGSTFGFKARDGSEWIVLKDTTCLENDSEDSQWEMWRAIRRNAVKELEQDWAAGLKDGEFIFASEEDTTRIKYILGERWSEEMSATSILRATWAELHCDFGFTESDILLGDTKVRFIAQIDQYMISEKEKNYSDQENRMAFSVADIFKTLTPNPLQGLEDDAFSQGNVHSNYSQWCGALKALIRNAPFMFKGGTWLQFLAFLLLGSEAFRAELALAGIEVQEDWCQRAREYNIHMYYEQIVDDRSAHEIQETFLNLRDFFRDLQLNNELAVVSEQEGMVKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C564</accession>
    <name>A0A177C564_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Letm1 RBD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CC84DRAFT_1166488</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG02655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033020.1">
        <property type="nucleotide sequence ID" value="XM_018178972.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C564"/>
    <dbReference type="STRING" id="1460663.A0A177C564"/>
    <dbReference type="GeneID" id="28762458"/>
    <dbReference type="InParanoid" id="A0A177C564"/>
    <dbReference type="OrthoDB" id="73691at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030003">
        <property type="term" value="P:intracellular monoatomic cation homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033122">
        <property type="entry name" value="LETM1-like_RBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044202">
        <property type="entry name" value="LETM1/MDM38-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14009">
        <property type="entry name" value="LEUCINE ZIPPER-EF-HAND CONTAINING TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14009:SF1">
        <property type="entry name" value="MITOCHONDRIAL PROTON_CALCIUM EXCHANGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07766">
        <property type="entry name" value="LETM1_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51758">
        <property type="entry name" value="LETM1_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Letm1 RBD" evidence="9">
        <location>
            <begin position="218"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="69"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="110"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAG02655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="378" mass="42824" checksum="66A0047AB1820AB8" modified="2016-09-07" version="1">MKPRPILHFTPPTPRSICPAFTAQCHRPLSYARTAPSSNEPQSFSQPRGKSIHNAFALRPHMRFASTAAVAATASRKPSTSSPSKSTKIAVSPRSTPFTAPVPQVRAKLNPPPETYPPDLQLPPRGPELYVKYLYRCGRSYITFYKQGVSNVRATLKLAKTLRAKASSQTPDKDKWHTVLTRAEWQVVNRSGNDRLRLPAFAALLVVFGEWLPLLVVYLTPVVPEPCRIPYQLERSLKSAEKRRQERERRLAIDAARLVARDRKPGVSSPGVIRPQTVDLEALDRADLFTLLSLDARFGVQPRVWDWLFLTPPKALLRWGLKRRIGYLQKDDEAIRRDGGFQALEVREVQRACVERGIRVLGRKEGELRKELAGWFER</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C6C4</accession>
    <name>A0A177C6C4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1261615</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG02956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033321.1">
        <property type="nucleotide sequence ID" value="XM_018185081.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C6C4"/>
    <dbReference type="STRING" id="1460663.A0A177C6C4"/>
    <dbReference type="GeneID" id="28768567"/>
    <dbReference type="InParanoid" id="A0A177C6C4"/>
    <dbReference type="OrthoDB" id="17560at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17630">
        <property type="entry name" value="DIENELACTONE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17630:SF87">
        <property type="entry name" value="DIENELACTONE HYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
        <property type="entry name" value="DLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dienelactone hydrolase" evidence="2">
        <location>
            <begin position="42"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="246"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="246"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="272"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG02956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="297" mass="32724" checksum="F8A7DA177081E7E9" modified="2016-09-07" version="1">MSSCPWTNKKEEGKETACVECISGTIHAGLPQGTIEPLYGLNTYIVGNRTNPRAIIVIYSDVFSHNLPNNKLIADSYAKSGEYLVYMPDFFEGDPLGLNLADVLIPTDAAKQSVLSKYGGLLAGMPGYLMWISRHGKDKTHKACVDWLQKLRRSDEVKGKKIGMVGMCWGGRFVFRAARSSESIQLADGKKVPLIDAGVALHPSNVVLPEDVEGLTVPVSVGWGEVDIVTPFKQKGQIEEIMKKRAEAGDPPPEMEHKVYTPGRHGFSVRGNPEDPAERKALEDSVTQVLDWFEKRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C6Y4</accession>
    <name>A0A177C6Y4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1167507</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441556">
        <property type="protein sequence ID" value="OAG02460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032825.1">
        <property type="nucleotide sequence ID" value="XM_018179190.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C6Y4"/>
    <dbReference type="GeneID" id="28762676"/>
    <dbReference type="InParanoid" id="A0A177C6Y4"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG02460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="108" mass="11762" checksum="27D92E42740B7903" modified="2016-09-07" version="1">MEEGEARPGSALSSKNLCKGPCIWEELGWYGWFGLVFLGFFSVGVVGKFGEEFGVFVASDWCFWTFKHGCLWGRVCEGGRGVGVSGKAAGARNEFSDLEATFADMVDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C7D4</accession>
    <name>A0A177C7D4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_901948</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG02610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032975.1">
        <property type="nucleotide sequence ID" value="XM_018187848.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C7D4"/>
    <dbReference type="GeneID" id="28771334"/>
    <dbReference type="InParanoid" id="A0A177C7D4"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="17"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG02610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="140" mass="15040" checksum="BD73722B8D466820" modified="2016-09-07" version="1">MPPCSLHCTALPPACPASASVPVAASEPRPSTLGRSPPPDRVQPWPPTRRGPGASDLLAQWAAQLGLPSLSLLRRPAKGVQSTQRARKEPVPNHADLASPWRHSCDGLRIALRDPRATRTYDCMPMCCTAHTRIALQTAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C7F8</accession>
    <name>A0A177C7F8_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_1166536</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG02708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033073.1">
        <property type="nucleotide sequence ID" value="XM_018178984.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C7F8"/>
    <dbReference type="FunCoup" id="A0A177C7F8">
        <property type="interactions" value="780"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177C7F8"/>
    <dbReference type="GeneID" id="28762470"/>
    <dbReference type="InParanoid" id="A0A177C7F8"/>
    <dbReference type="OrthoDB" id="10027013at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051052">
        <property type="entry name" value="Diverse_substrate_MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44942">
        <property type="entry name" value="METHYLTRANSF_11 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44942:SF4">
        <property type="entry name" value="METHYLTRANSFERASE TYPE 11 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase" evidence="3">
        <location>
            <begin position="60"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAG02708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="346" mass="38640" checksum="FB4DC45E29201B95" modified="2016-09-07" version="1">MSNASSTSGTAYANLDWTQYIRYRPSYPPSLRELIYRYHTRNVPGKTTAPDASTHWDSLLDIGGGIGISSVPFIRDFRTMHLLDPSPLNHEKARVFLAEHVSVNNLQTKLEFTVAKAEEYANKPAVTAESGVSLAICASTAHFIDPDMLVKAMYRLMRPGGTMAIYSYWLPVFPDLDPGLSVVYTKTVTRAMRLCIRDEATRNVFADAVARLCTGTTVMDAIAVPDDLFEGIQRIQINPQTALSLDTFREDPAVPFTPLDSQVREHDGKYTYVSGTDPEAEGWTMSVDLDFLHGMIRTILPADIQLSKEQHEELYGDLDRAFVERCLSGYTLAMWGLDMILATRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C866</accession>
    <name>A0A177C866_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1197962</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG02890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033255.1">
        <property type="nucleotide sequence ID" value="XM_018181544.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C866"/>
    <dbReference type="STRING" id="1460663.A0A177C866"/>
    <dbReference type="GeneID" id="28765030"/>
    <dbReference type="InParanoid" id="A0A177C866"/>
    <dbReference type="OrthoDB" id="5412502at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="230"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="255"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG02890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="406" mass="44992" checksum="CF39C4494605A2A2" modified="2016-09-07" version="1">MLWLQAENGETVLQQLQLDIVGFLAILGEGSVLANAQVSTLSKWIFLPRLIPAPQALMRPTRPTVLEPVPGHITGIYSGNYKDTINHIGNIVCDANSLPAHSVRVVRIKRTGVSLVKSRTIAPLTGVLFLGFFLSCVLLGLSIWRQDGMSLVATCLLSFLSSLIGYGNKWELKLPERRSKKGNVPPGDVVIRYPKGSFLIVRCPEEVARELYFAPETIQYLLQHGPAYRLLSLVGTIMLMGGVICLANAQIESQIAWAASYMLLGSSYWIVAALPAKLHWDYSCYTVTNERLSDSNQSAKGFPSESPTFTQALWKAIVVSKQIGWVRLSNACPDTPAWQRWLKQAEQQARTVQLVESKTEEKVTTWEIPDWDAQQALVALLNEQATDDTASIKNAEEVVVRNMEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C8E9</accession>
    <name>A0A177C8E9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Inheritance of peroxisomes protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CC84DRAFT_1123092</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for peroxisome inheritance.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Peroxisome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the INP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG03676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034041.1">
        <property type="nucleotide sequence ID" value="XM_018175648.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C8E9"/>
    <dbReference type="STRING" id="1460663.A0A177C8E9"/>
    <dbReference type="GeneID" id="28759134"/>
    <dbReference type="InParanoid" id="A0A177C8E9"/>
    <dbReference type="OrthoDB" id="4097008at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005780">
        <property type="term" value="C:extrinsic component of intraperoxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045033">
        <property type="term" value="P:peroxisome inheritance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024758">
        <property type="entry name" value="Inp1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12634">
        <property type="entry name" value="Inp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="65"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="216"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="389"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="554"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="8"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="34"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="286"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="312"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="403"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="558"/>
            <end position="572"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAG03676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="594" mass="65266" checksum="E832ABA6DAE3E634" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C8L0</accession>
    <name>A0A177C8L0_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Scaffold protein Scd2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_878510</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG03973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034338.1">
        <property type="nucleotide sequence ID" value="XM_018187759.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C8L0"/>
    <dbReference type="FunCoup" id="A0A177C8L0">
        <property type="interactions" value="132"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177C8L0"/>
    <dbReference type="GeneID" id="28771245"/>
    <dbReference type="InParanoid" id="A0A177C8L0"/>
    <dbReference type="OrthoDB" id="548867at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902494">
        <property type="term" value="C:catalytic complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090726">
        <property type="term" value="C:cortical dynamic polarity patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000747">
        <property type="term" value="P:conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030010">
        <property type="term" value="P:establishment of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902917">
        <property type="term" value="P:positive regulation of mating projection assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032878">
        <property type="term" value="P:regulation of establishment or maintenance of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd06890">
        <property type="entry name" value="PX_Bem1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11878">
        <property type="entry name" value="SH3_Bem1p_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11879">
        <property type="entry name" value="SH3_Bem1p_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000093">
        <property type="entry name" value="Protein kinase activator Bem1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1520.10:FF:000041">
        <property type="entry name" value="Protein kinase activator Bem1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035550">
        <property type="entry name" value="Bem1/Scd2_PX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035548">
        <property type="entry name" value="Bem1/Scd2_SH3_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035549">
        <property type="entry name" value="Bem1/Scd2_SH3_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051228">
        <property type="entry name" value="NADPH_Oxidase/PX-Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053793">
        <property type="entry name" value="PB1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15706:SF2">
        <property type="entry name" value="SH3 AND PX DOMAIN-CONTAINING PROTEIN 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15706">
        <property type="entry name" value="SH3 MULTIPLE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00499">
        <property type="entry name" value="P67PHOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54277">
        <property type="entry name" value="CAD &amp; PB1 domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51745">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="5">
        <location>
            <begin position="31"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="5">
        <location>
            <begin position="171"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="PX" evidence="6">
        <location>
            <begin position="333"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="domain" description="PB1" evidence="7">
        <location>
            <begin position="547"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="102"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="280"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="466"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="106"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="309"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="320"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="467"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="531"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAG03973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="632" mass="69057" checksum="5521AE0B763A0AE5" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C8T7</accession>
    <name>A0A177C8T7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">Mitochondrial import inner membrane translocase subunit Tim21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CC84DRAFT_1166118</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. Required to keep the TOM and the TIM23 complexes in close contact. At some point, it is released from the TOM23 complex to allow protein translocation into the mitochondrial matrix.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the TIM23 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Mitochondrion inner membrane</location>
            <topology evidence="1 11">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the TIM21 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG03975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034340.1">
        <property type="nucleotide sequence ID" value="XM_018178878.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C8T7"/>
    <dbReference type="FunCoup" id="A0A177C8T7">
        <property type="interactions" value="228"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177C8T7"/>
    <dbReference type="GeneID" id="28762364"/>
    <dbReference type="InParanoid" id="A0A177C8T7"/>
    <dbReference type="OrthoDB" id="436405at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005744">
        <property type="term" value="C:TIM23 mitochondrial import inner membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.320:FF:000002">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit tim21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.320">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit Tim21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013261">
        <property type="entry name" value="Tim21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038552">
        <property type="entry name" value="Tim21_IMS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13032">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13032:SF6">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08294">
        <property type="entry name" value="TIM21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="11" id="KW-0811">Translocation</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="11" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00060204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OAG03975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="143" mass="16060" checksum="578CF76815E6882E" modified="2016-09-07" version="1">MTCGVGYFLFADVFSPDSKTAHFNRATTAIRAHPECQRLLGPGNEIAAHGEASWSRLARNRYLSSSTETDKWGTEHLRFRFYVEGPLGQGVAHVHLTKRPSQNEYEYHTLAVDVKGHQRVYLENADGKAGGKVAPKIFGARWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C912</accession>
    <name>A0A177C912_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxymuconolactone decarboxylase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_963765</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG03247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033612.1">
        <property type="nucleotide sequence ID" value="XM_018187982.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C912"/>
    <dbReference type="STRING" id="1460663.A0A177C912"/>
    <dbReference type="GeneID" id="28771468"/>
    <dbReference type="InParanoid" id="A0A177C912"/>
    <dbReference type="OrthoDB" id="2567457at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1290.10">
        <property type="entry name" value="AhpD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029032">
        <property type="entry name" value="AhpD-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34846">
        <property type="entry name" value="4-CARBOXYMUCONOLACTONE DECARBOXYLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G11590)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34846:SF11">
        <property type="entry name" value="4-CARBOXYMUCONOLACTONE DECARBOXYLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G11590)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69118">
        <property type="entry name" value="AhpD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG03247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="206" mass="21854" checksum="6DEC43449FFD26AD" modified="2016-09-07" version="1">MDSERIPAATRFPTVPPASLSAAQKPVHDHVTSVSQYVFGDNPPFAWADGEGSLIGPYTSMLYAPTIGTAFFDHAIKVGTDQRLPIRVKEIAILAVGGHFQAAYENYAHARLAKLCGLSDEQVASALAGRDPIQGLADAEITAYRLALAMVSGKGPVSEEIWSQVRRYFGQEESAVLVFLISSYAYIAMVLNAGAVPAPATATATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2023-06-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C9M6</accession>
    <name>A0A177C9M6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_886873</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG04086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034451.1">
        <property type="nucleotide sequence ID" value="XM_018187795.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C9M6"/>
    <dbReference type="GeneID" id="28771281"/>
    <dbReference type="InParanoid" id="A0A177C9M6"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG04086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="113" mass="12608" checksum="886364BDDDDB2834" modified="2016-09-07" version="1">MDGLDWDTSFLVIWFWVSIGCLDGGGRRALCDRYHIQSRQTILFMSFLSLIGCPGRDSLTYKLRDIRGAWKGESEAFSPKDCSGVEATTEMGKLLVLSTSSKVWIAVLKSPLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CAS1</accession>
    <name>A0A177CAS1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Alpha-ketoglutarate-dependent taurine dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_1247165</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TfdA dioxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG04824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035189.1">
        <property type="nucleotide sequence ID" value="XM_018184226.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CAS1"/>
    <dbReference type="STRING" id="1460663.A0A177CAS1"/>
    <dbReference type="GeneID" id="28767712"/>
    <dbReference type="InParanoid" id="A0A177CAS1"/>
    <dbReference type="OrthoDB" id="10257314at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016706">
        <property type="term" value="F:2-oxoglutarate-dependent dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.130.10:FF:000008">
        <property type="entry name" value="Alpha-ketoglutarate-dependent taurine dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051323">
        <property type="entry name" value="AtsK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT SULFONATE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468:SF9">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT TAURINE DIOXYGENASE (AFU_ORTHOLOGUE AFUA_3G01010)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="7">
        <location>
            <begin position="90"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAG04824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="381" mass="42726" checksum="A86808E4B882AE96" modified="2016-09-07" version="1">MAPGLVLPISEEIKDTVQPKKDTLGLPEPARKRLEKAGIDLSNGYPYRPAKPLFLDDVIKIRDYDREHVDPGSRADPEKKALLSAAKEVIHLTAHIGTEIVGLQLKDLTDQQKDELGLLIAERSVVFFRDQDISPQQQRTLGEWYGEIEVHPQVPSVPGVPGTTVIWPALQATESPASFRQTGGASRWHTDLVHERQPAGVTHLHNDTIPKVGGDTLWASGYAAYEKLSPDFRKIIDGKQAVYRSAHPYLDRNHPEAGPKFIERIHPLVRVHPATGWKALWVNRAMTVRIVGLDKAESDVILNYLYDVYEKNVDIQVRFRWTPGTSALWDNRITIHNASWDYEGNEPRHGTRVTALAEKPFFKADAPTRRQALGLAGPEDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CAU0</accession>
    <name>A0A177CAU0_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ACB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_1166110</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ACBP family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG03962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034327.1">
        <property type="nucleotide sequence ID" value="XM_018178876.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CAU0"/>
    <dbReference type="FunCoup" id="A0A177CAU0">
        <property type="interactions" value="398"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CAU0"/>
    <dbReference type="GeneID" id="28762362"/>
    <dbReference type="InParanoid" id="A0A177CAU0"/>
    <dbReference type="OrthoDB" id="346910at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000062">
        <property type="term" value="F:fatty-acyl-CoA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000582">
        <property type="entry name" value="Acyl-CoA-binding_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035984">
        <property type="entry name" value="Acyl-CoA-binding_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23310:SF62">
        <property type="entry name" value="ACYL-COA BINDING PROTEIN 1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23310">
        <property type="entry name" value="ACYL-COA-BINDING PROTEIN, ACBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00887">
        <property type="entry name" value="ACBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00689">
        <property type="entry name" value="ACOABINDINGP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47027">
        <property type="entry name" value="Acyl-CoA binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51228">
        <property type="entry name" value="ACB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACB" evidence="3">
        <location>
            <begin position="2"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAG03962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="90" mass="10220" checksum="8B2851C5532B4E41" modified="2016-09-07" version="1">MPSAKFEEVYKKTREIKTGPSNDDLLNLYAYAKVAQGEDIEKAPKPGMMDFTGKAKRKRWQEVVDANTSQADAEKKYIELGESLIKTHLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CC26</accession>
    <name>A0A177CC26_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DUF1772-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CC84DRAFT_1259768</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ATG33 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG04359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034724.1">
        <property type="nucleotide sequence ID" value="XM_018184939.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CC26"/>
    <dbReference type="STRING" id="1460663.A0A177CC26"/>
    <dbReference type="GeneID" id="28768425"/>
    <dbReference type="InParanoid" id="A0A177CC26"/>
    <dbReference type="OrthoDB" id="5336366at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051668">
        <property type="entry name" value="ATG33"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37278">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 33-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37278:SF1">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 33-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAG04359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="165" mass="17823" checksum="B67B30E28D112969" modified="2016-09-07" version="1">MTSPMVSICKFVGTISLGLLTGISASLSTTALPALLTLPTAVTARSTHTYLSSKTRLLSSYLRHITTFTLFSAYLLSPRRFRHPYLLYTSIFAFVSGPGVDYAVAFREGKNEQRALLDLEAQGDDVNGEQVRHAVERMKFTEAVRAGISGVAFAMGVVGIWGDGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CCQ3</accession>
    <name>A0A177CCQ3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Negative regulator of differentiation 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CC84DRAFT_793682</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG04490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034855.1">
        <property type="nucleotide sequence ID" value="XM_018187424.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CCQ3"/>
    <dbReference type="STRING" id="1460663.A0A177CCQ3"/>
    <dbReference type="GeneID" id="28770910"/>
    <dbReference type="InParanoid" id="A0A177CCQ3"/>
    <dbReference type="OrthoDB" id="6407164at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051252">
        <property type="term" value="P:regulation of RNA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12520">
        <property type="entry name" value="RRM1_MRN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12523">
        <property type="entry name" value="RRM2_MRN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12521">
        <property type="entry name" value="RRM3_MRN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12522">
        <property type="entry name" value="RRM4_MRN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000047">
        <property type="entry name" value="Differentiation 1 negative regulator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000064">
        <property type="entry name" value="Differentiation 1 negative regulator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000130">
        <property type="entry name" value="Differentiation 1 negative regulator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000120">
        <property type="entry name" value="Negative regulator of differentiation 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039171">
        <property type="entry name" value="Cwc2/Slt11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034195">
        <property type="entry name" value="Mrn1_RRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018835">
        <property type="entry name" value="RNA-binding_domain_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14089">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR RBM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14089:SF8">
        <property type="entry name" value="RNA-BINDING PROTEIN MRN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10378">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="191"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="282"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="416"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="507"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="23"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="575"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="689"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="768"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="23"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="585"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="633"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="709"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="777"/>
            <end position="792"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAG04490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="825" mass="87822" checksum="0A0C020A01F01430" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2023-06-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CD84</accession>
    <name>A0A177CD84_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1165505</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG05181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035546.1">
        <property type="nucleotide sequence ID" value="XM_018178726.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CD84"/>
    <dbReference type="GeneID" id="28762212"/>
    <dbReference type="InParanoid" id="A0A177CD84"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG05181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="72" mass="7930" checksum="65FB65DF98867FF9" modified="2016-09-07" version="1">MYSGFLGQSGWYVHSELIALTSSITDTLPAYMVPTMFILVDSMPLAALGQIAEETSQPTKDIRDVLEATDYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CDM8</accession>
    <name>A0A177CDM8_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GEgh 16 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_808091</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG04868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035233.1">
        <property type="nucleotide sequence ID" value="XM_018187496.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CDM8"/>
    <dbReference type="STRING" id="1460663.A0A177CDM8"/>
    <dbReference type="GeneID" id="28770982"/>
    <dbReference type="InParanoid" id="A0A177CDM8"/>
    <dbReference type="OrthoDB" id="3241054at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021476">
        <property type="entry name" value="Egh16-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34618:SF3">
        <property type="entry name" value="GEGH 16 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34618">
        <property type="entry name" value="SURFACE PROTEIN MAS1, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11327">
        <property type="entry name" value="Egh16-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008058055" description="GEgh 16 protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="269"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="323"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="269"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="289"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="323"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG04868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="366" mass="36840" checksum="EA44EAC9080C3906" modified="2016-09-07" version="1">MRYQTSILALAAVFSSVQAHGTIESAIGESGESKGFKVDDSLARNCTGISPCQQDTTIIRDSEITQNIVNSCGRTEIDGNIDVGGETEKAIAAKKVTTVKKGSQLAVTIHQVNADGAGPYECDLDVTSNAATSFVKLQVTNNVPGVNGLSQAEATNFTINVQMPDDFNCVGASTGNICTVRCRNTAVAGPFGGCFPVQQTDGTGRANNQTAGSITTAQTLDGINKQIAQNKKDLPVAIAAIAAAGAVAGNADASRVSALVPAASQTAAAGAGTGNAANGNTGNANTGNGKNGNGNGRNRGNGNGNAANAANGNAANGNGNAANAANGNAANGNGQAATGNGRNRNNNRRDRSRKFLSRFINPNAMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CE85</accession>
    <name>A0A177CE85_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_1122112</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG05119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035484.1">
        <property type="nucleotide sequence ID" value="XM_018175627.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CE85"/>
    <dbReference type="STRING" id="1460663.A0A177CE85"/>
    <dbReference type="GeneID" id="28759113"/>
    <dbReference type="InParanoid" id="A0A177CE85"/>
    <dbReference type="OrthoDB" id="245697at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034044">
        <property type="term" value="C:exomer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000747">
        <property type="term" value="P:conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13945">
        <property type="entry name" value="Chs5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000453">
        <property type="entry name" value="Chitin biosynthesis protein CHS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.120.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031673">
        <property type="entry name" value="Chs5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052827">
        <property type="entry name" value="CHS_Export/Cell_Fusion_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031669">
        <property type="entry name" value="Fn3_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47351">
        <property type="entry name" value="CHITIN BIOSYNTHESIS PROTEIN CHS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47351:SF1">
        <property type="entry name" value="CHITIN BIOSYNTHESIS PROTEIN CHS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16892">
        <property type="entry name" value="CHS5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16893">
        <property type="entry name" value="fn3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12738">
        <property type="entry name" value="PTCB-BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="75"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="2">
        <location>
            <begin position="163"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="260"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="265"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="320"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="331"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAG05119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="398" mass="43257" checksum="5D745B8B466C1C84" modified="2016-09-07" version="1">MLVSLTVGKVDAGVAVLLTEDKRLIEFPSILLPPDISSGSIVDIEVTRNAEKESDEAAKFHALQSNIFRTFGQREPTPPVLRCRNATQTSVVLEWDPIDIATAELRSLTLYRNGSKAGTIPRPTEVHSTKLSGLAVDTEYVFHLVLRTSAGTFSSDKLKVQTHKMTDLSGITITPGHMPAALRESLQRDVEEIGAKLVDAVRIDTTHFVCTEGRGPAWEKAVENNIPVVVPDWVKGCKRDGRIVGVRGYYLNADPRLRSVGGGASQSHSSQQQQAPSSVTSPRTEITPPTPDRPRHEPDNDNSAPPPPPPKDVEEKREVSPSPSASPEPKVATDEQKVRTEDLKPTADESEDDSEDDGHASSNEKAVEAGLPSREKQPPPPTAEDDDDDQAGFQDVQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CEK4</accession>
    <name>A0A177CEK4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Bromodomain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CC84DRAFT_1094049</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG05170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035535.1">
        <property type="nucleotide sequence ID" value="XM_018174546.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CEK4"/>
    <dbReference type="FunCoup" id="A0A177CEK4">
        <property type="interactions" value="572"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CEK4"/>
    <dbReference type="GeneID" id="28758032"/>
    <dbReference type="InParanoid" id="A0A177CEK4"/>
    <dbReference type="OrthoDB" id="784962at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05499">
        <property type="entry name" value="Bromo_BDF1_2_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050935">
        <property type="entry name" value="Bromo_chromatin_reader"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027353">
        <property type="entry name" value="NET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038336">
        <property type="entry name" value="NET_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22880:SF225">
        <property type="entry name" value="BROMODOMAIN-CONTAINING PROTEIN BET-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22880">
        <property type="entry name" value="FALZ-RELATED BROMODOMAIN-CONTAINING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17035">
        <property type="entry name" value="BET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51525">
        <property type="entry name" value="NET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bromo" evidence="4">
        <location>
            <begin position="315"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="4">
        <location>
            <begin position="520"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="domain" description="NET" evidence="5">
        <location>
            <begin position="705"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="47"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="407"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="617"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="663"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="786"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="88"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="126"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="155"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="167"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="189"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="230"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="258"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="439"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="467"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="630"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="815"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="829"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="851"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAG05170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="865" mass="93582" checksum="A25FB3C1C6CC0FB9" modified="2016-09-07" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CEL5</accession>
    <name>A0A177CEL5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CC84DRAFT_1145191</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG05641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036006.1">
        <property type="nucleotide sequence ID" value="XM_018176496.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CEL5"/>
    <dbReference type="FunCoup" id="A0A177CEL5">
        <property type="interactions" value="16"/>
    </dbReference>
    <dbReference type="GeneID" id="28759982"/>
    <dbReference type="InParanoid" id="A0A177CEL5"/>
    <dbReference type="OrthoDB" id="6133115at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015793">
        <property type="term" value="P:glycerol transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000061">
        <property type="entry name" value="MFS sugar transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF69">
        <property type="entry name" value="SUGAR TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="67"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="190"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="291"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="321"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="349"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="384"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="415"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="444"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="27"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAG05641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="545" mass="59459" checksum="3A6EE290AE72A6A5" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CF48</accession>
    <name>A0A177CF48_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="15">ATP-dependent RNA helicase DBP8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CC84DRAFT_1146180</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG06234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036599.1">
        <property type="nucleotide sequence ID" value="XM_018176547.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CF48"/>
    <dbReference type="FunCoup" id="A0A177CF48">
        <property type="interactions" value="809"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CF48"/>
    <dbReference type="GeneID" id="28760033"/>
    <dbReference type="InParanoid" id="A0A177CF48"/>
    <dbReference type="OrthoDB" id="10261904at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010467">
        <property type="term" value="P:gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17955">
        <property type="entry name" value="DEADc_DDX49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF24">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10 15" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="14">
        <location>
            <begin position="73"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="12">
        <location>
            <begin position="104"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="13">
        <location>
            <begin position="318"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="9">
        <location>
            <begin position="73"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="32"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OAG06234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="502" mass="55375" checksum="109E62E0576B7B00" modified="2016-09-07" version="1">MASISDYSSSDEEMLEQNGSRKKRRLSPVEKPTQQPLATTSRIKAKQITAPSRVQDGSGAPAVSEISNASERVSFASLNVSPWLVASLASMEIKKPTGIQKECIPEILKGRDCIGGSRTGTGKTVAFSVPILQKWSEDPCGIFALMITPTRELAIQIFEQVKAIGSRQSVKVILITGGADQREQALQLASRPHVVIATPGRLAEHIKTSGEDTICGLRRVKFVVFDEADRLLAPGKGSMLPDLETCLSILPPPERRQTLLFTATVTPEVLALKEKPRTPGKPPIFVCEVDTETLAIPPKLQQLYIMTPVTHKECYLHVLLSTPENVKKSVIIFCNRTKTATLLEYMLRLLDHRVTALHSGLKQAERVSNLARFRAQAARILVATDVAARGLDIPEVALVVNFDVPRDPDDYIHRVGRTARAGRVGHSVTLVGQRDVDLIHAIEERVGKELEEYEEEGVSVEGRVVREALKPVTEKKREALLQIEEGRDVLGKRKVGMQKRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2023-06-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CFF9</accession>
    <name>A0A177CFF9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_731273</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG05682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036047.1">
        <property type="nucleotide sequence ID" value="XM_018187207.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CFF9"/>
    <dbReference type="GeneID" id="28770693"/>
    <dbReference type="InParanoid" id="A0A177CFF9"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG05682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="90" mass="10621" checksum="0B09D34911D07C58" modified="2016-09-07" version="1">MSKPALSILLRRHHPLRHLLHHNHRRLLRLHQILHLLHHRHPRNLHSHRSKRRSDGILRHVFYHAAASLGAGSRNTALRSRNPCRMIVGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CFJ7</accession>
    <name>A0A177CFJ7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cyclase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1243831</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Cyclase 1 superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG05497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035862.1">
        <property type="nucleotide sequence ID" value="XM_018184129.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CFJ7"/>
    <dbReference type="STRING" id="1460663.A0A177CFJ7"/>
    <dbReference type="GeneID" id="28767615"/>
    <dbReference type="InParanoid" id="A0A177CFJ7"/>
    <dbReference type="OrthoDB" id="5396at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004061">
        <property type="term" value="F:arylformamidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:L-tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.50">
        <property type="entry name" value="Putative cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007325">
        <property type="entry name" value="KFase/CYL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037175">
        <property type="entry name" value="KFase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34861">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34861:SF11">
        <property type="entry name" value="CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04199">
        <property type="entry name" value="Cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102198">
        <property type="entry name" value="Putative cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008058113" description="Cyclase" evidence="2">
        <location>
            <begin position="17"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG05497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="351" mass="38802" checksum="52B49139A21904ED" modified="2016-09-07" version="1">MLPFVLTALCAHLATAQTDPYANWPSYADLPLNASFPPKAAWGVWGNDDVHGALNHITNDTRKKSAEEIQTGQAFNLNLELSFFPQPANIERKPLVHLFQPGDGYTDDVITFNTQMSTQIDGLRHFAYSIDGNTSTYRYYNDLIPDYEHVIGHDYTSVLGIQQAADKGIVARGILLDYKAWMDSQNKTYDALSGWSVPASDLEKVAEWQGLPSNWSRPGDILVVRFGWIEAFGKLNETERAIIVRGPGEWVGMKADDESAEWLWNKKLAMVGADNPAFESTPFGHVIGGHDGMSLHQLLISGWGQSIVEFLDLEKLAPALHALNRSSFFMTIQPVNKIGGIASPPNAMAVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CFK4</accession>
    <name>A0A177CFK4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1145809</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG06001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036366.1">
        <property type="nucleotide sequence ID" value="XM_018176528.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CFK4"/>
    <dbReference type="GeneID" id="28760014"/>
    <dbReference type="InParanoid" id="A0A177CFK4"/>
    <dbReference type="OrthoDB" id="3675232at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="323"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="12"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="348"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG06001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="565" mass="62631" checksum="2E93F5A21FDEEE61" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CG56</accession>
    <name>A0A177CG56_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Carbon-nitrogen hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1164195</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG05730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036095.1">
        <property type="nucleotide sequence ID" value="XM_018178440.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CG56"/>
    <dbReference type="STRING" id="1460663.A0A177CG56"/>
    <dbReference type="GeneID" id="28761926"/>
    <dbReference type="InParanoid" id="A0A177CG56"/>
    <dbReference type="OrthoDB" id="201515at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008418">
        <property type="term" value="F:protein-N-terminal asparagine amidohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070773">
        <property type="term" value="F:protein-N-terminal glutamine amidohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039703">
        <property type="entry name" value="Nta1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11750">
        <property type="entry name" value="PROTEIN N-TERMINAL AMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11750:SF26">
        <property type="entry name" value="PROTEIN N-TERMINAL AMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG05730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="308" mass="34058" checksum="5128ED552B206E90" modified="2016-09-07" version="1">MKIALLQFAPDVGTVQANIKRADDLLQRAKIPVDLDWLILPEMAFSGYNFHSLEEITPYLEPTTSGITTHWAIQVAQHYNCHVTVGYPERTLPSPSSPHQEPTNYNSTVTVSPTGAILQNYRKSFLYYTDETWAAEPPERFKVEHLQKLGNVIQGICMDINPHRFLAPWSDYEFASAALAPVPPLSHSDSPTPQGTNPLIVVSMAWLSHLTASEIAAEPAAPDVATVAYWVERFQPVVERSKDVPGPWYVVLANRCGSEKSVCYAGSSTVIKVEDGGVSLFETCGRGEERVCVVDLEGEPRFSVRSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CGL3</accession>
    <name>A0A177CGL3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1164642</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG06361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036726.1">
        <property type="nucleotide sequence ID" value="XM_018178529.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CGL3"/>
    <dbReference type="GeneID" id="28762015"/>
    <dbReference type="InParanoid" id="A0A177CGL3"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG06361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="120" mass="13322" checksum="5CCA0F3026F80DEE" modified="2016-09-07" version="1">MQPEDLMAAIPSWFIDKKNGCFILKLFATWNVYDDPDVGSRSEFLATNFTLPETLCKMSTATVCADLSPMAKKEDDGKSDHGLEDGNVVLQDVEVSDHTDEDEDDGVVWLDDEDSEGDVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CGW7</accession>
    <name>A0A177CGW7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FAD-binding PCMH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CC84DRAFT_1088054</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG06813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037178.1">
        <property type="nucleotide sequence ID" value="XM_018174232.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CGW7"/>
    <dbReference type="STRING" id="1460663.A0A177CGW7"/>
    <dbReference type="GeneID" id="28757718"/>
    <dbReference type="InParanoid" id="A0A177CGW7"/>
    <dbReference type="OrthoDB" id="2151789at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF13">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008058186" description="FAD-binding PCMH-type domain-containing protein" evidence="5">
        <location>
            <begin position="21"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="6">
        <location>
            <begin position="18"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAG06813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="462" mass="49653" checksum="F410173A4BFDA9CF" modified="2016-09-07" version="1">MRRAAVVAAAVAALGATVSADTCASVAATSSIQIKKQLDIGYATEQANYWSTACGAMKPSCQLPNQGFASIDGGPLISTRELNEVIYDAGNGVVRVGPGNDWDDVIGALDGTGVTVVGGRIGDVGVGGLVLGGGLSFLSTQYGWVANNVVEYEIVLANASIVTASESHNADLWKALKGGINNYGIVTAYTFKAHPQGQIWGGNIAYTADKSAEILAAVRDFTEYYPDDKAGIIMTAELTQFGVIDIWLMFLFYDGPTPPAGVFDNFTAIAHLSDDTKSRSYSDLLTHNNFGVIKTEIYTIATEMIPLPSADVGPDFLGAIYDNWRNTTESVIDAAGLIGSIALQPIPKRLARKAMEAGGDMIDLDDEIDRIILEFDLSWLSPLDSARMDVATQKFYTGSKDLVEQYQADDKLPEGYLPLFANDAYYRQDYFGRLRTADFARTVRDAVDPSGFFASRTGGWKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CH01</accession>
    <name>A0A177CH01_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">TPR-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1163148</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG06844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037209.1">
        <property type="nucleotide sequence ID" value="XM_018178189.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CH01"/>
    <dbReference type="GeneID" id="28761675"/>
    <dbReference type="InParanoid" id="A0A177CH01"/>
    <dbReference type="OrthoDB" id="5328412at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="287"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG06844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="552" mass="59410" checksum="3FA42BBEC6358E8D" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CH31</accession>
    <name>A0A177CH31_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_1163174</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG06875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037240.1">
        <property type="nucleotide sequence ID" value="XM_018178198.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CH31"/>
    <dbReference type="STRING" id="1460663.A0A177CH31"/>
    <dbReference type="GeneID" id="28761684"/>
    <dbReference type="InParanoid" id="A0A177CH31"/>
    <dbReference type="OrthoDB" id="5412288at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019622">
        <property type="entry name" value="Rrn9_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10680">
        <property type="entry name" value="RRN9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="709"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="748"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="164"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="220"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="365"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="595"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="645"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="12"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="40"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="51"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="229"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="309"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="374"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="401"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="417"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="436"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="454"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="606"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="667"/>
            <end position="679"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAG06875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="781" mass="86331" checksum="DFAE2B2DF33A4385" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CHC3</accession>
    <name>A0A177CHC3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">D-galacturonic acid reductase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1164567</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG06258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036623.1">
        <property type="nucleotide sequence ID" value="XM_018178512.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CHC3"/>
    <dbReference type="STRING" id="1460663.A0A177CHC3"/>
    <dbReference type="GeneID" id="28761998"/>
    <dbReference type="InParanoid" id="A0A177CHC3"/>
    <dbReference type="OrthoDB" id="2127032at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006740">
        <property type="term" value="P:NADPH regeneration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.10:FF:000030">
        <property type="entry name" value="NAD binding Rossmann fold oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000778">
        <property type="entry name" value="NAD binding Rossmann fold oxidoreductase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42840:SF6">
        <property type="entry name" value="BINDING ROSSMANN FOLD OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G11930)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42840">
        <property type="entry name" value="NAD(P)-BINDING ROSSMANN-FOLD SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="1">
        <location>
            <begin position="96"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG06258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="413" mass="45999" checksum="D8EBBCA5E9C8CDFF" modified="2016-09-07" version="1">MAPLEVLMVGTGEYTTGFVGGGASTSDKKVGVVGLTLFDLRRRGKVGNLSMVGVSGDKFPAIRQHLDKNISQAYNGLDVSFQEFPKEGKRDPDAYKEAIDALPKGSAITIFTPDTTHYPIALYAIERGHHVLVTKPAVKLLEHHQKLYEAAKKHNVFVYVEHHKRFDPAYADARFRATKLGDFNYFYSYMSQPKSQLETFKAWAGKDSDISYYLNSHHIDINESMVPGFKPVRVMGSAAKGIATDLGCDPATEDTITLLVDWVKKDDPSKRATGVYTAGWAAPQKAGVHSNQYFHYMASKGEIRVNQAKRGYDVTDDDTGLLWYNPFYMKYAPDEEGNFAGQIGYGYISFEKFVDAVNQLNEGKVTLDQLDSRPLPTLKNTIATTAILEAGRRSLDENRPIEIVEENGTWSLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CHD6</accession>
    <name>A0A177CHD6_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glycoside hydrolase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_750054</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG06127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036492.1">
        <property type="nucleotide sequence ID" value="XM_018187289.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CHD6"/>
    <dbReference type="STRING" id="1460663.A0A177CHD6"/>
    <dbReference type="GeneID" id="28770775"/>
    <dbReference type="InParanoid" id="A0A177CHD6"/>
    <dbReference type="OrthoDB" id="3257981at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051118">
        <property type="term" value="F:glucan endo-1,3-alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11577">
        <property type="entry name" value="GH71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005197">
        <property type="entry name" value="Glyco_hydro_71"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03659">
        <property type="entry name" value="Glyco_hydro_71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG06127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="500" mass="54017" checksum="2E991571CE8D2035" modified="2016-09-07" version="1">MCGVRPRRVSSLPGFADGIALGFIYNKLEIVEGGIHFDSFVTCYTFHKFALFQSLTSHSFCLVCNMRASTTSVALGLLAAANAAPFKTSTVKRQDAGKIVAAHFMIGIMATRSSAADYDDDMKKAKAAGIDAFALNIAKDDYTDAQLNYAYESAANNDMKVFISFDYNYFETSENEAVGAKLKEYCGKPGQLMVDGKCFASTFNGDNDPSKLFNANTVRTAAGTDLYLVPNLSPTGIRDATAVGDIDGSFNWIGWDSNGANRAPTAESNVTTSDFDSKYTEWLAGKTYMAPVSPWFFTNFPSKAWVFPGDLLWFRRWNEILALAPQMLEIITWNDYGESHYIGPDSETSLHNDDGSSAWANGFPHDGWLEMAQPYIAAYKAGSKEISVTEDKLVYWYRPTPKAACGTFDGIDTLQDAVFVVALLQSEGNVTVTSGSNTQTFYAPAGASAYQVAMGTGAQTFALLRGGADVFSAKGGLEITENCSPVNLNAFVGVAKGNAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CHI5</accession>
    <name>A0A177CHI5_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">EKC/KEOPS complex subunit GON7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CC84DRAFT_1258232</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. GON7 likely plays a supporting role to the catalytic subunit KAE1 in the complex. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. The complex is required for efficient recruitment of transcriptional coactivators.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the EKC/KEOPS complex composed of at least BUD32, CGI121, GON7, KAE1 and PCC1; the whole complex dimerizes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Telomere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the GON7 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG07024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037389.1">
        <property type="nucleotide sequence ID" value="XM_018184805.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CHI5"/>
    <dbReference type="GeneID" id="28768291"/>
    <dbReference type="InParanoid" id="A0A177CHI5"/>
    <dbReference type="OrthoDB" id="2288868at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014849">
        <property type="entry name" value="EKC/KEOPS_Gon7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08738">
        <property type="entry name" value="Gon7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0010">Activator</keyword>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0779">Telomere</keyword>
    <keyword evidence="11" id="KW-0804">Transcription</keyword>
    <keyword evidence="9" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="90"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00025393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OAG07024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="156" mass="16811" checksum="5FF2C0E8B6EED4E0" modified="2016-09-07" version="1">MLSLTATYAASSTPSSEPPFTHELPPLPAANDTPARTAYLAALTSATKALQDDINAFLTQKMADDKSAADAKEEENYGEEVRRNMAVLASDTDAERHAAASSPRRPWQATSNCADSQRMPGRPSLARTVLPIRFLGARGFPHHLPAMTRSIPHAMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CIH1</accession>
    <name>A0A177CIH1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CC84DRAFT_1195199</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG06772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037137.1">
        <property type="nucleotide sequence ID" value="XM_018181394.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CIH1"/>
    <dbReference type="GeneID" id="28764880"/>
    <dbReference type="InParanoid" id="A0A177CIH1"/>
    <dbReference type="OrthoDB" id="4161376at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010573">
        <property type="entry name" value="MFS_Str1/Tri12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF109">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06609">
        <property type="entry name" value="TRI12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="69"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="107"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="135"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="162"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="227"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="266"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="297"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="380"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="409"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="560"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="71"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="15"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAG06772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="609" mass="66210" checksum="9F93A708D167D6EB" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CJI1</accession>
    <name>A0A177CJI1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CC84DRAFT_1242229</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG07132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037497.1">
        <property type="nucleotide sequence ID" value="XM_018184080.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CJI1"/>
    <dbReference type="STRING" id="1460663.A0A177CJI1"/>
    <dbReference type="GeneID" id="28767566"/>
    <dbReference type="InParanoid" id="A0A177CJI1"/>
    <dbReference type="OrthoDB" id="268400at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF181">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="48"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="105"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="129"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="151"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="187"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="220"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="320"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="358"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="401"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="427"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="466"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="496"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="47"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAG07132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="528" mass="58731" checksum="24EAE28CDDEE9A6C" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CJJ4</accession>
    <name>A0A177CJJ4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RING finger domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CC84DRAFT_632503</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG07009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037374.1">
        <property type="nucleotide sequence ID" value="XM_018186956.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CJJ4"/>
    <dbReference type="STRING" id="1460663.A0A177CJJ4"/>
    <dbReference type="GeneID" id="28770442"/>
    <dbReference type="InParanoid" id="A0A177CJJ4"/>
    <dbReference type="OrthoDB" id="264354at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16495">
        <property type="entry name" value="RING_CH-C4HC3_MARCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011016">
        <property type="entry name" value="Znf_RING-CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46347">
        <property type="entry name" value="RING/FYVE/PHD ZINC FINGER SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46347:SF1">
        <property type="entry name" value="RING_FYVE_PHD ZINC FINGER SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12906">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00744">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51292">
        <property type="entry name" value="ZF_RING_CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="157"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="220"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="262"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="RING-CH-type" evidence="6">
        <location>
            <begin position="59"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="18"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAG07009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="309" mass="34656" checksum="9F05E152B6250BEA" modified="2016-09-07" version="1">MSSTSGFEREPGWTWPEDILREDEPERPSSARQRSPPQSSSTASGSAPQDAPGANSSKQRHWRPRQCRICLDTVQPTFDVPSENLPSFLQSTGNVKYEDENGRLIRPCMCKGSAKYVHEGCLQAWRHADPSYGRRNYWQCPTCKFKYRLARLGAGKVVGSIAAQIVLTIGILVTVVFILGFFADPIINLYVDPWGFLSPWSSPYDDHYYEDEPATWSEHFAKGLASMGVLGFLKALLASPLQLFRIGGGRGRNTARDRYEQVSWVIIVIGVGTFLLAIYKGVRAWSRRTLEKAGERVMDVQGDDDDDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CK35</accession>
    <name>A0A177CK35_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1258368</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG07200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037565.1">
        <property type="nucleotide sequence ID" value="XM_018184822.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CK35"/>
    <dbReference type="STRING" id="1460663.A0A177CK35"/>
    <dbReference type="GeneID" id="28768308"/>
    <dbReference type="InParanoid" id="A0A177CK35"/>
    <dbReference type="OrthoDB" id="4779541at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="451"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="160"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="207"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="243"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="255"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="281"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="318"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="342"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="383"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="410"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="492"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG07200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="577" mass="61458" checksum="B91B3AA76F628858" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CKM6</accession>
    <name>A0A177CKM6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1173649</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038459.1">
        <property type="nucleotide sequence ID" value="XM_018180048.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CKM6"/>
    <dbReference type="GeneID" id="28763534"/>
    <dbReference type="InParanoid" id="A0A177CKM6"/>
    <dbReference type="OrthoDB" id="3942453at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="152"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG08094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="197" mass="21556" checksum="3A193222B1AE6368" modified="2016-09-07" version="1">MCVAELNVSLMPCRHRWYHLSRACSPSTDLSNCDKKLGLAGWEIKCDFCPYCSGWNLTKSEYRLVGNDRAPAIGGLSRTPSLSLNTARRESRRGSLSRTDSSNSIAILAQEKNRALNARVDAYLKVAPEPPLPSPYPAPLADVNEDDGVALSSSPSDTSSEGPESVRHSSTSTQGDSVSIIKRMRHKSKRLSMSLFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CKY4</accession>
    <name>A0A177CKY4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1243111</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG07528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037893.1">
        <property type="nucleotide sequence ID" value="XM_018184111.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CKY4"/>
    <dbReference type="GeneID" id="28767597"/>
    <dbReference type="InParanoid" id="A0A177CKY4"/>
    <dbReference type="OrthoDB" id="3775889at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="15"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="39"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG07528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="248" mass="28535" checksum="412EC6A544E07F72" modified="2016-09-07" version="1">MSWVSHPTRSSSWRQNQQPQASNPPSWSRQNWRRRSDSSESSCSSLTSSSPPSSCGPSPPSKSWDSDWRAQYVPRSPSSVSNARTAFEDLYPGTVMYLPRQEDVPKSSVFYKRMWKRDDSPWGHPVVILKKEVVSDMEMVQCQLITSFRDRETFARKSDASKENIALIENTDNIKAHQGLNGVYTRLMTLELWSDRFPKTSFVNFYDKAGPQGNTFWIEYGNIQPLLAGRNIVFDEESLKRIINKQVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CLG1</accession>
    <name>A0A177CLG1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Nuclear elongation and deformation protein-like protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CC84DRAFT_716871</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the lipin family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG07782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038147.1">
        <property type="nucleotide sequence ID" value="XM_018187140.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CLG1"/>
    <dbReference type="FunCoup" id="A0A177CLG1">
        <property type="interactions" value="427"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CLG1"/>
    <dbReference type="GeneID" id="28770626"/>
    <dbReference type="InParanoid" id="A0A177CLG1"/>
    <dbReference type="OrthoDB" id="4567at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008195">
        <property type="term" value="F:phosphatidate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009062">
        <property type="term" value="P:fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019432">
        <property type="term" value="P:triglyceride biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000063">
        <property type="entry name" value="Nuclear elongation and deformation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026058">
        <property type="entry name" value="LIPIN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007651">
        <property type="entry name" value="Lipin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013209">
        <property type="entry name" value="LNS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031315">
        <property type="entry name" value="LNS2/PITP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057124">
        <property type="entry name" value="Ned1-like_M"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12181">
        <property type="entry name" value="LIPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12181:SF12">
        <property type="entry name" value="PHOSPHATIDATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04571">
        <property type="entry name" value="Lipin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08235">
        <property type="entry name" value="LNS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24565">
        <property type="entry name" value="Ned1_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00775">
        <property type="entry name" value="LNS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LNS2/PITP" evidence="4">
        <location>
            <begin position="417"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="96"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="321"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="624"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="682"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="145"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="626"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="682"/>
            <end position="735"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAG07782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="776" mass="85403" checksum="E1E4B15A23FD213B" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CLK8</accession>
    <name>A0A177CLK8_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_1066531</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG07667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038032.1">
        <property type="nucleotide sequence ID" value="XM_018173635.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CLK8"/>
    <dbReference type="GeneID" id="28757121"/>
    <dbReference type="InParanoid" id="A0A177CLK8"/>
    <dbReference type="OrthoDB" id="5413793at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF131">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="38"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="82"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="162"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="195"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="242"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="25"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAG07667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="274" mass="30333" checksum="42B98C697F16A5F2" modified="2016-09-07" version="1" fragment="single">DQRLIILWVNAVLITFTLCAVVSRAGRKIFVVGNFGMHDGLIVLAAVSATVFSSFQMVSTGLGLGLHQADVDPANMPELRKLLLTSNVFYFLCNWAIKHALLLFYSEITRERTHRIAIYAMHGVAFSFGLSSVLVDLLRCRPFKKAFYPDIEGYCFNMDAFYLYNSSMMLATDVVLYAMPVVFTRNLMLRRAQKVGLNCLFALGGLVLAASAARVWAIYIGAVKPDFTFRFATTMLFSVTENHIAILVACAPSIKIVALLVFPKLTSSLGKFAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CLZ3</accession>
    <name>A0A177CLZ3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CC84DRAFT_1140935</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038691.1">
        <property type="nucleotide sequence ID" value="XM_018176303.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CLZ3"/>
    <dbReference type="GeneID" id="28759789"/>
    <dbReference type="InParanoid" id="A0A177CLZ3"/>
    <dbReference type="OrthoDB" id="4142200at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17356">
        <property type="entry name" value="MFS_HXT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000026">
        <property type="entry name" value="MFS quinate transporter QutD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF35">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="7"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="78"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="100"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="175"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="265"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="300"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="328"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="371"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="412"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="441"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="10"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAG08326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="524" mass="57661" checksum="0FE853055D76C92C" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CMY3</accession>
    <name>A0A177CMY3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Asteroid domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_563590</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the asteroid family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038613.1">
        <property type="nucleotide sequence ID" value="XM_018186706.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CMY3"/>
    <dbReference type="STRING" id="1460663.A0A177CMY3"/>
    <dbReference type="GeneID" id="28770192"/>
    <dbReference type="InParanoid" id="A0A177CMY3"/>
    <dbReference type="OrthoDB" id="5297549at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026832">
        <property type="entry name" value="Asteroid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039436">
        <property type="entry name" value="Asteroid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15665">
        <property type="entry name" value="ASTEROID PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15665:SF1">
        <property type="entry name" value="PROTEIN ASTEROID HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12813">
        <property type="entry name" value="XPG_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Asteroid" evidence="3">
        <location>
            <begin position="129"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="516"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="532"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAG08248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="564" mass="63752" checksum="710B6B2F62B654FD" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CN13</accession>
    <name>A0A177CN13_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1162746</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039290.1">
        <property type="nucleotide sequence ID" value="XM_018178082.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CN13"/>
    <dbReference type="STRING" id="1460663.A0A177CN13"/>
    <dbReference type="GeneID" id="28761568"/>
    <dbReference type="InParanoid" id="A0A177CN13"/>
    <dbReference type="OrthoDB" id="16464at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050177">
        <property type="entry name" value="Lipid_A_modif_metabolic_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43245">
        <property type="entry name" value="BIFUNCTIONAL POLYMYXIN RESISTANCE PROTEIN ARNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43245:SF11">
        <property type="entry name" value="LD23561P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="1">
        <location>
            <begin position="18"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG08925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="379" mass="43177" checksum="414614FB040D96FA" modified="2016-09-07" version="1">MAVEEGSSTPAASDKPAVLIIGGLGYTGRFLAKYIHDNNLASEIRLVDKHLPELAWLAPEFKDVCTRERFVQADASREQSFPRIFDRPNGKEFDFVFNCGGETRFSQEDEVYKLRTYGLSMAMGKEAARRKVKCFIESSTGMVYKSDSVPRKETDKTKPWSKLAKWKLQAEEDLAKIEGLNLLVFRMSHVYGPYTSKFLATALCMARVYQSLGKEMKWLWKEDLRTNTVHVDDVVRALWTGAEWFVQAPRTSPQTFNIVDHGNTSQGLMATLMHDTFNIGTGFHGTLISTFARMNLDHVVDEVNDETLDPWAELQNQAGISNTTPLTPFMEKELLHNTDLSLDGSAFEQETGFRYQHEKLTKEEVEKVIESYKTMGWWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CNI2</accession>
    <name>A0A177CNI2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_581559</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038907.1">
        <property type="nucleotide sequence ID" value="XM_018186761.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CNI2"/>
    <dbReference type="GeneID" id="28770247"/>
    <dbReference type="InParanoid" id="A0A177CNI2"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG08542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="102" mass="11568" checksum="70D25547D5DD805B" modified="2016-09-07" version="1">MITVPPRTFRFRTCRPSLCKSCHTMLLTIGPQTRQRARGKVDYRYPPLDPHGARRPPATRFGRLDFVKTPFNSNPVAIRLFASAVVCSMLIPILWRNAANAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CPC3</accession>
    <name>A0A177CPC3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1162628</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039133.1">
        <property type="nucleotide sequence ID" value="XM_018178046.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CPC3"/>
    <dbReference type="STRING" id="1460663.A0A177CPC3"/>
    <dbReference type="GeneID" id="28761532"/>
    <dbReference type="InParanoid" id="A0A177CPC3"/>
    <dbReference type="OrthoDB" id="3799742at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="309"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="80"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="191"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="324"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG08768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="334" mass="35254" checksum="1B8D636C98595243" modified="2016-09-07" version="1">MFLSVKERARQIALGQFTAPTTSAPLIDLAPEPVPAPAPPRTTGAKDATQKAAAESKKTKGSKGAPTKEPTPKVAPPLKAPAKAAPPKATPAPASRATPSRTTTAPPEAPTPKKASSKSKITKEPPTPTTEAPPSKKSSSKSKTTKEPSSPKPGSSKPAREPPSPRFGSYMSPWSSSAKPPPSPKPESQKSKSSSTSKSKSSSSSKPKRAKSPPKRVDSPLASSDDEDDDPLSALKSACLKQITAVPGLGNRQLVVVLKQRSSGEWYAALKDTGADKYLKSWMNREKTFKTRREALEAYLGFATKMRERSSGSGMGMGWFPMSPRTSSPKGKGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CPG4</accession>
    <name>A0A177CPG4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Replication factor C subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CC84DRAFT_589564</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the activator 1 small subunits family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039183.1">
        <property type="nucleotide sequence ID" value="XM_018186798.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CPG4"/>
    <dbReference type="FunCoup" id="A0A177CPG4">
        <property type="interactions" value="642"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CPG4"/>
    <dbReference type="GeneID" id="28770284"/>
    <dbReference type="InParanoid" id="A0A177CPG4"/>
    <dbReference type="OrthoDB" id="4199794at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031390">
        <property type="term" value="C:Ctf18 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005663">
        <property type="term" value="C:DNA replication factor C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031391">
        <property type="term" value="C:Elg1 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031389">
        <property type="term" value="C:Rad17 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003689">
        <property type="term" value="F:DNA clamp loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902983">
        <property type="term" value="P:DNA strand elongation involved in mitotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006272">
        <property type="term" value="P:leading strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033314">
        <property type="term" value="P:mitotic DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007062">
        <property type="term" value="P:sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070914">
        <property type="term" value="P:UV-damage excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18140">
        <property type="entry name" value="HLD_clamp_RFC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.272.10:FF:000011">
        <property type="entry name" value="Replication factor C subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000237">
        <property type="entry name" value="replication factor C subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.272.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050238">
        <property type="entry name" value="DNA_Rep/Repair_Clamp_Loader"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013748">
        <property type="entry name" value="Rep_factorC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047854">
        <property type="entry name" value="RFC_lid"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669">
        <property type="entry name" value="REPLICATION FACTOR C / DNA POLYMERASE III GAMMA-TAU SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669:SF20">
        <property type="entry name" value="REPLICATION FACTOR C SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21960">
        <property type="entry name" value="RCF1-5-like_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08542">
        <property type="entry name" value="Rep_fac_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="post-AAA+ oligomerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="8">
        <location>
            <begin position="65"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00040745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAG08818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="415" mass="45385" checksum="E77431514AB8277F" modified="2016-09-07" version="1">MADFFNIKARQQAAAQASSSKAPASKAVTNRLQPWVEKYRPKTLSEVTAQDNTIQILSRTLQSTNLPHMLFYGPPGTGKTSTILALAKQLYGPELIKTRVLELNASDERGISIVRAKVKDFARQQLSSAPTHSITVEDESVEGGFKQVRYRDRYPCPPFKIIVLDEADSMTQDAQSALRRTMETYSKMTRFCLVCNYVTRIIDPLASRCSKFRFKSLDQGNAVKRVEDIAKLEGVNLDAGVSEELVRVAEGDLRKAITFLQSAARLVGAAQKEAAAGGKRKAHAVMDDDDEMDIDSAAPSAAAVSKVHIAEIAGVIPETTLESLTSAIFPGSQSQIQYTKIAKVVEDMIAEGWSAAQTVGQLYERVLFDERVGDLQKMRITGLFSEVDKRLGDGGDEHLAVLDLGLRISGVLCQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CPL6</accession>
    <name>A0A177CPL6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1255508</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG09465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039830.1">
        <property type="nucleotide sequence ID" value="XM_018184543.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CPL6"/>
    <dbReference type="STRING" id="1460663.A0A177CPL6"/>
    <dbReference type="GeneID" id="28768029"/>
    <dbReference type="InParanoid" id="A0A177CPL6"/>
    <dbReference type="OrthoDB" id="5241710at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="14"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG09465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="211" mass="23496" checksum="CE067900301705C2" modified="2016-09-07" version="1">MASTIPNERRLRQITVATLLPAFPLLIASGAMVGKENYNNYNWNWNQHLYPTVIYFGLLPTFLSAITSGIALQAKHDPLAKRAPWVTGLWVLNDLVLALGNLAILIPIWISEPAAMGGHGDWMMLETYATVFLMSNMFIHTYLALYPFKSLFNFECQKKCPHCHGRLGGSHVETVATKGEGYSLLRAENYLDEHEAEASTGPIRLSTDSEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CQC6</accession>
    <name>A0A177CQC6_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cyclase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1235575</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Cyclase 1 superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG09723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040088.1">
        <property type="nucleotide sequence ID" value="XM_018183849.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CQC6"/>
    <dbReference type="STRING" id="1460663.A0A177CQC6"/>
    <dbReference type="GeneID" id="28767335"/>
    <dbReference type="InParanoid" id="A0A177CQC6"/>
    <dbReference type="OrthoDB" id="5396at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004061">
        <property type="term" value="F:arylformamidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:L-tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.50">
        <property type="entry name" value="Putative cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007325">
        <property type="entry name" value="KFase/CYL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037175">
        <property type="entry name" value="KFase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34861">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34861:SF9">
        <property type="entry name" value="CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04199">
        <property type="entry name" value="Cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102198">
        <property type="entry name" value="Putative cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG09723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="329" mass="37744" checksum="A58F7983E989D7DD" modified="2016-09-07" version="1">MAQYKSFSDLPKFDELKDKRRFWVAEAGTKDEGLGMLRYLTPEHVAEVVQSEVRTGERVCVNWDMTRLETPGFNRFPCDHQIVPIPNYEGIAWDDIWRFNPQAGSQWDGFRHYGAEQPNGKRAWYGGTTGDEISKMESDRIGIGHWAQDGIAARGFLIDYVSYAEKKGQKVNGMTGHAITLDEVKEIAKECRIEFRPGDIFFLRCGFTKTWESLSLDEKKQYRADTQVQKHKHSGLIQSEEVTRFLWDNHIVAVAGDGVSFEVRPNKDHDWSLHHICLAGWGVPIGEMFDLERLAELCKKLNRWTFFVTSSPLNHPRAVSSPPNCMVLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CR59</accession>
    <name>A0A177CR59_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_451433</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG09701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040066.1">
        <property type="nucleotide sequence ID" value="XM_018186318.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CR59"/>
    <dbReference type="GeneID" id="28769804"/>
    <dbReference type="InParanoid" id="A0A177CR59"/>
    <dbReference type="OrthoDB" id="3904016at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="267"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="270"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG09701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="309" mass="34988" checksum="17897985D8996DCB" modified="2016-09-07" version="1">MDYGVRPVISYSPDRLSDCFDACVHNTQMMHNLEKWGPALHNLRGQKGYLEGMLSKTVTTLNALRDRQTRNQCILSTNPTPRTKRKKIQQDRWRTDKTIQTCENEEKIILDCLRVCENNIQTLEAIIYPPESSLNSAEHYGSNSYGELDTASFDWQGWTDDLVISPFERTRTGPLPLDEVSPDTMAGCTQPRSAFLVAPPNSAYTKFMPRPEATTFKPSAAHMQLSVTQLARELDKLTISGFLASKRMSSIHRRRFSDEAIAFRRFPSTVEPTPTRKGSSSSWPGQRRLRGNEDRGSAGKARLKRCISI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CR94</accession>
    <name>A0A177CR94_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14 15">Multifunctional fusion protein</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="15">Serine/threonine-protein phosphatase 2A activator</fullName>
                <ecNumber evidence="15">5.2.1.8</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="15">Phosphotyrosyl phosphatase activator</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="14">Glutathione peroxidase</fullName>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CC84DRAFT_1172057</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Acts as a regulatory subunit for PP2A-like phosphatases modulating their activity or substrate specificity, probably by inducing a conformational change in the catalytic subunit, a direct target of the PPIase. Can reactivate inactive phosphatase PP2A-phosphatase methylesterase complexes (PP2Ai) in presence of ATP and Mg(2+) by dissociating the inactive form from the complex.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a hydroperoxide + [thioredoxin]-dithiol = an alcohol + [thioredoxin]-disulfide + H2O</text>
            <dbReference type="Rhea" id="RHEA:62620"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:35924"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.11.1.24"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 15">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the PTPA-type PPIase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the glutathione peroxidase family.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="15"/>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG09488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039853.1">
        <property type="nucleotide sequence ID" value="XM_018179952.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CR94"/>
    <dbReference type="FunCoup" id="A0A177CR94">
        <property type="interactions" value="547"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CR94"/>
    <dbReference type="GeneID" id="28763438"/>
    <dbReference type="InParanoid" id="A0A177CR94"/>
    <dbReference type="OrthoDB" id="16120at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000159">
        <property type="term" value="C:protein phosphatase type 2A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008160">
        <property type="term" value="F:protein tyrosine phosphatase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140824">
        <property type="term" value="F:thioredoxin-dependent peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00340">
        <property type="entry name" value="GSH_Peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04087">
        <property type="entry name" value="PTPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000010">
        <property type="entry name" value="Glutathione peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1150:FF:000002">
        <property type="entry name" value="Serine/threonine-protein phosphatase 2A activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000889">
        <property type="entry name" value="Glutathione_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029759">
        <property type="entry name" value="GPX_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029760">
        <property type="entry name" value="GPX_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004327">
        <property type="entry name" value="Phstyr_phstse_ac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043170">
        <property type="entry name" value="PTPA_C_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037218">
        <property type="entry name" value="PTPA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10012">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE 2A REGULATORY SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10012:SF5">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 2A ACTIVATOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00255">
        <property type="entry name" value="GSHPx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03095">
        <property type="entry name" value="PTPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01011">
        <property type="entry name" value="GLUTPROXDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140984">
        <property type="entry name" value="PTPA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00460">
        <property type="entry name" value="GLUTATHIONE_PEROXID_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00763">
        <property type="entry name" value="GLUTATHIONE_PEROXID_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51355">
        <property type="entry name" value="GLUTATHIONE_PEROXID_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="5 15" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 15" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6 14" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="11" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 15" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="Thioredoxin" evidence="17">
        <location>
            <begin position="1"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="167"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="170"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="212"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU361210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="OAG09488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="604" mass="66795" checksum="FAA0B513E142D8E6" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CRE6</accession>
    <name>A0A177CRE6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Carboxyvinyl-carboxyphosphonate phosphorylmutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1255541</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate = pyruvate + succinate</text>
            <dbReference type="Rhea" id="RHEA:16809"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:57429"/>
            <dbReference type="EC" id="4.1.3.30"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG09512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039877.1">
        <property type="nucleotide sequence ID" value="XM_018184546.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CRE6"/>
    <dbReference type="STRING" id="1460663.A0A177CRE6"/>
    <dbReference type="GeneID" id="28768032"/>
    <dbReference type="InParanoid" id="A0A177CRE6"/>
    <dbReference type="OrthoDB" id="1923844at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046421">
        <property type="term" value="F:methylisocitrate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00377">
        <property type="entry name" value="ICL_PEPM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039556">
        <property type="entry name" value="ICL/PEPM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018523">
        <property type="entry name" value="Isocitrate_lyase_ph_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42905">
        <property type="entry name" value="PHOSPHOENOLPYRUVATE CARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42905:SF2">
        <property type="entry name" value="PHOSPHOENOLPYRUVATE CARBOXYLASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13714">
        <property type="entry name" value="PEP_mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00161">
        <property type="entry name" value="ISOCITRATE_LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG09512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="310" mass="33209" checksum="37F36F96D10E6F18" modified="2016-09-07" version="1">MAQINGNKPLSAVQKLRIMLSDPAKFVVCPGVYDGYTARIALAEGAECLYMTGAGTTMSRLGMPDMGLAQMSDMLTNASMLASISPHTPLIADADTGYGSALMVSRTVSSYIRAGVAGLHLEDQVVTKRCGHLRGKQLVDTEEFVSRIRAAVMAREQSGGDIVIIARTDALAGEGYAEALKRLRVAIAAGAEVAFLEGVTTRQEAESLTRDLAPTPCLFNNVPGGVSPDFSVKEAREIGYKIAIFPLLALEVVYPAVRNACRELLDEGSVKSVEKDGKRWGPRELFNVCGLDELMEFDRKAGGKGYVEDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CRL7</accession>
    <name>A0A177CRL7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mid2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_1161170</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040539.1">
        <property type="nucleotide sequence ID" value="XM_018177668.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CRL7"/>
    <dbReference type="STRING" id="1460663.A0A177CRL7"/>
    <dbReference type="GeneID" id="28761154"/>
    <dbReference type="InParanoid" id="A0A177CRL7"/>
    <dbReference type="OrthoDB" id="5425848at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16861">
        <property type="entry name" value="GLYCOPROTEIN 38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16861:SF10">
        <property type="entry name" value="MID2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008058594" description="Mid2 domain-containing protein" evidence="3">
        <location>
            <begin position="25"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="218"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="303"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="279"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="342"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="342"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="360"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAG10174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="372" mass="38320" checksum="7ACCDBECFB578EF2" modified="2016-09-07" version="1">MVFFHAPAAVLSLLALSFLPSVSATLFLKPTPAARLNDFERLKLALAKRQNACAGTPCGFEDAYCCTGGQQCFTDANMKALCTAGDGGWIYSTFYYTAAETVTKQSVWSTYVGSSPTGSACNPSDMCGTACCGSGEWCQDASINLCKVIGGGSAGSPGVTGTGTNPSAPVRPTSNGVIVITATGSATATVPFTTPIPTGVNGTLVESNSGGGGLSGGAIAGIVIGVIAGIILLLLICFYCCAKAAFDGVLALIGLGKKRKHTHEETTYIEEHHSGAAAGGRRWYGQAGSARPSRPAKKEGGGLGKLLGIGAGAAAIGALLGMKKKNEKRYDDKSTTVTDSSYYYSDYTSSSSASSDDRRTRHTRHSSRPSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CS77</accession>
    <name>A0A177CS77_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7143 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1172528</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040416.1">
        <property type="nucleotide sequence ID" value="XM_018179987.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CS77"/>
    <dbReference type="GeneID" id="28763473"/>
    <dbReference type="InParanoid" id="A0A177CS77"/>
    <dbReference type="OrthoDB" id="2497581at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055567">
        <property type="entry name" value="DUF7143"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37592">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37592:SF1">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23631">
        <property type="entry name" value="DUF7143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008058526" description="DUF7143 domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7143" evidence="2">
        <location>
            <begin position="34"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG10051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="192" mass="19670" checksum="CD6456974A8E3C1B" modified="2016-09-07" version="1">MYTPKSLVAIVAALALGATAAPTTLTRRQNACFVVGSTTLPAETADSANALASTVTCGTGTTIGNVPDVTTNGVSFSDIDFSKSSSTPLQFALDKFATADPLASTDLATFQTNLDLYTATEAGIRSEGGNLAIKEPKFFLAFQVARIKTAQGVAIADPGQTVEHLLGKVQKNAGSADKGLLSQVNALATKLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CSZ6</accession>
    <name>A0A177CSZ6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_479157</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040686.1">
        <property type="nucleotide sequence ID" value="XM_018186432.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CSZ6"/>
    <dbReference type="STRING" id="1460663.A0A177CSZ6"/>
    <dbReference type="GeneID" id="28769918"/>
    <dbReference type="InParanoid" id="A0A177CSZ6"/>
    <dbReference type="OrthoDB" id="5427204at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="226"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="365"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="9"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="61"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="229"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="300"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="318"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG10321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="583" mass="64511" checksum="8F358527CA195FCE" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CTK5</accession>
    <name>A0A177CTK5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1173193</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041229.1">
        <property type="nucleotide sequence ID" value="XM_018180014.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CTK5"/>
    <dbReference type="GeneID" id="28763500"/>
    <dbReference type="InParanoid" id="A0A177CTK5"/>
    <dbReference type="OrthoDB" id="3797007at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG10864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="335" mass="37388" checksum="92EF757F8EB973F0" modified="2016-09-07" version="1">MSDTNANFGATHDEPSVVMDIDPPDMTTHQPEAIHNQSEGFAPNVADNVMGTPLPDVAANASTTEVHGLVPVSDETTEPVVLPQDTEWIEDHAYQVVTVRAKHDPCLDKAKALAVVLLEHYYPADQGYRVEHAAFPLVQFGGWRTWIYPEDCYTATKRKSDNMKAGVKKNAEPVYETWAGNILADKFHRIFPEHIAGYVALNEVQYEDGSTGWAQHTYLAIMMDDLDTGYAILMLGPRFEFYDYHAKPAWEEKPWEHYLGPNPEDADYDPDLAAEDETSFFSHLGGGDVDSDAWIVDIRSKKPAETLAAVDKLFKSVVGRDVEYRDGYALPGPKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CU44</accession>
    <name>A0A177CU44_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">lytic cellulose monooxygenase (C4-dehydrogenating)</fullName>
            <ecNumber evidence="15">1.14.99.56</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CC84DRAFT_1138919</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>[(1-&gt;4)-beta-D-glucosyl]n+m + reduced acceptor + O2 = 4-dehydro-beta-D-glucosyl-[(1-&gt;4)-beta-D-glucosyl]n-1 + [(1-&gt;4)-beta-D-glucosyl]m + acceptor + H2O.</text>
            <dbReference type="EC" id="1.14.99.56"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the polysaccharide monooxygenase AA9 family.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.56" evidence="15"/>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040775.1">
        <property type="nucleotide sequence ID" value="XM_018176212.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CU44"/>
    <dbReference type="STRING" id="1460663.A0A177CU44"/>
    <dbReference type="GeneID" id="28759698"/>
    <dbReference type="InParanoid" id="A0A177CU44"/>
    <dbReference type="OrthoDB" id="5271017at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21175">
        <property type="entry name" value="LPMO_AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049892">
        <property type="entry name" value="AA9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005103">
        <property type="entry name" value="AA9_LPMO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353:SF10">
        <property type="entry name" value="ENDO-BETA-1,4-GLUCANASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03443">
        <property type="entry name" value="AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="8" id="KW-0186">Copper</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 16" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013062787" description="lytic cellulose monooxygenase (C4-dehydrogenating)" evidence="16">
        <location>
            <begin position="16"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="Auxiliary Activity family 9 catalytic" evidence="17">
        <location>
            <begin position="16"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00045077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF03443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="OAG10410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="229" mass="23851" checksum="BDF8D4ABCFA70FE4" modified="2016-09-07" version="1">MKFLGALILAATASAHYTFPALVAGGSATGQWQYVRKTTNYQSNGPVTDVTSNQIRCYELSPGSPAQGTYEVAAGSTIGFTAQSSISHPGTLQFYMAKAPSGQTAASFDGSGNVWFKIYEQGPTISGGQLSWPSNGKSQVTVPIPKSLPSGEYLFRVEHIALHSAGSAGGAQFYISCAQVKVTNGGNGTPGPLVSFPGAYKATDPGILINIYYPVPTSYTPPGPKVWSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CUE2</accession>
    <name>A0A177CUE2_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SURF1-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CC84DRAFT_1161459</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Probably involved in the biogenesis of the COX complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Mitochondrion inner membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SURF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040897.1">
        <property type="nucleotide sequence ID" value="XM_018177747.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CUE2"/>
    <dbReference type="FunCoup" id="A0A177CUE2">
        <property type="interactions" value="357"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CUE2"/>
    <dbReference type="GeneID" id="28761233"/>
    <dbReference type="InParanoid" id="A0A177CUE2"/>
    <dbReference type="OrthoDB" id="10040024at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06662">
        <property type="entry name" value="SURF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002994">
        <property type="entry name" value="Surf1/Shy1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045214">
        <property type="entry name" value="Surf1/Surf4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23427">
        <property type="entry name" value="SURFEIT LOCUS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23427:SF2">
        <property type="entry name" value="SURFEIT LOCUS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02104">
        <property type="entry name" value="SURF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50895">
        <property type="entry name" value="SURF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="299"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAG10532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="336" mass="38611" checksum="A1EB0811BD4F9915" modified="2016-09-07" version="1">MSKPNPFLNLFRRYYSHQPVRPPTNTRTRPSLHPQCLRARFRTQFLLLRRNLGGAPNSSHTPLDPSFVSILDRPAKMARVGKQHGPGLIILAIIPITAFALGCWQVQRLGWKTELVARFEDRLTFPPLELPLRIDPDAIADFDYRRVYAKGKLRHDQEMLIGPRMLEGEEGYTVVTPLEREDAQGNKSKILCCRGWIRKDAAKHWFRKKNGALPEGDVTVEGLLRIPPKGNMFTPRNIPEEGKWFFPNVEEMAKWSGSQAVWVEETMTPDLLESYAREPKGIPVGRAPTVNLRNNHTQYIFTWYALSFATSIMFWMVVKKPISGQAKRVRHSVDWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CUI4</accession>
    <name>A0A177CUI4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">AAT family amino acid transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CC84DRAFT_1161388</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040812.1">
        <property type="nucleotide sequence ID" value="XM_018177723.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CUI4"/>
    <dbReference type="FunCoup" id="A0A177CUI4">
        <property type="interactions" value="215"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CUI4"/>
    <dbReference type="GeneID" id="28761209"/>
    <dbReference type="InParanoid" id="A0A177CUI4"/>
    <dbReference type="OrthoDB" id="3900342at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000017">
        <property type="entry name" value="Amino acid permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004762">
        <property type="entry name" value="Amino_acid_permease_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00913">
        <property type="entry name" value="2A0310"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF1">
        <property type="entry name" value="GENERAL AMINO-ACID PERMEASE GAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="111"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="164"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="195"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="221"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="309"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="350"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="409"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="435"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="481"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="522"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="10">
        <location>
            <begin position="83"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="28"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OAG10447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="589" mass="63999" checksum="28F208CF47D3BD5E" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CVH2</accession>
    <name>A0A177CVH2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1211222</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG11564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041929.1">
        <property type="nucleotide sequence ID" value="XM_018182359.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CVH2"/>
    <dbReference type="GeneID" id="28765845"/>
    <dbReference type="InParanoid" id="A0A177CVH2"/>
    <dbReference type="OrthoDB" id="10559603at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008058648" evidence="1">
        <location>
            <begin position="20"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG11564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="136" mass="14453" checksum="F7C6B62C7623E552" modified="2016-09-07" version="1">MHLKIAASALALFTAVANAETRISFYTAKDCSSGYLSTATGHGSASNTEAENEFSYTVNAYVGGIAIDNLDDFQNQLNDDNGCVFTDITCCEYAPKCKEPSPVPSSGGYCITYDKYMGTVGVSSTVCDSLCIDNVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CVP5</accession>
    <name>A0A177CVP5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Monosaccharide transporter-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_1139611</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041164.1">
        <property type="nucleotide sequence ID" value="XM_018176247.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CVP5"/>
    <dbReference type="GeneID" id="28759733"/>
    <dbReference type="InParanoid" id="A0A177CVP5"/>
    <dbReference type="OrthoDB" id="6133115at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000078">
        <property type="entry name" value="MFS maltose transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF10">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="96"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="120"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="154"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="185"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="273"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="309"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="337"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="369"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="405"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="440"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="18"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAG10799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="525" mass="58075" checksum="AAD917780AB33945" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CVR3</accession>
    <name>A0A177CVR3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ankyrin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_1049379</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG11645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042010.1">
        <property type="nucleotide sequence ID" value="XM_018173454.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CVR3"/>
    <dbReference type="STRING" id="1460663.A0A177CVR3"/>
    <dbReference type="GeneID" id="28756940"/>
    <dbReference type="InParanoid" id="A0A177CVR3"/>
    <dbReference type="OrthoDB" id="539213at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0085020">
        <property type="term" value="P:protein K6-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171:SF8">
        <property type="entry name" value="BRCA1-ASSOCIATED RING DOMAIN PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="37"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="70"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="104"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="137"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="170"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAG11645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="235" mass="25245" checksum="E64CB72C77EA4687" modified="2016-09-07" version="1" fragment="single">GWTPLMTAVRNGNLSAVQLLVSAGADLEATSSDKDYEAFTPLIAAIHEKHSAIASHLISAGAALNVHDKWGYTPINRAGQAGLLSIVRLLVEHGESVDEQNNKTGWSVISEAAWHGFPDVVDYLAEAGADLETRDGNRDTSLQKASINGSTECVRRLLAHGANPNTHNYWDWTPLHDAGIRGYAGIVELLLKAGADMEARNSRAEGENTALILSSKDKESVRLFVDHGADLDAKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CVR7</accession>
    <name>A0A177CVR7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_501069</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041325.1">
        <property type="nucleotide sequence ID" value="XM_018186557.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CVR7"/>
    <dbReference type="GeneID" id="28770043"/>
    <dbReference type="InParanoid" id="A0A177CVR7"/>
    <dbReference type="OrthoDB" id="5388417at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG10960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="175" mass="19868" checksum="010DBDDDF85442EF" modified="2016-09-07" version="1">MDSISFIVTRDNDAEKAQLNTLQTTLLVALLTLFVLAVVLIGSLFFLRRVRRARKNAEAQLPLYEKRQSSHRRLTIQATRESVVVYQERRDLLANSSSPPQSPVPEIRITFPDEVDSAGKRQSGRVVVVRVGEHSVGLEPLDEDLPPYERDGDRFDSLDLDRIGGLKEKDDKYYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CW41</accession>
    <name>A0A177CW41_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1214360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG11112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041477.1">
        <property type="nucleotide sequence ID" value="XM_018182622.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CW41"/>
    <dbReference type="GeneID" id="28766108"/>
    <dbReference type="InParanoid" id="A0A177CW41"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG11112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="116" mass="13549" checksum="7977C540079AD5C4" modified="2016-09-07" version="1">MPRPYEIEILAGALAQDIVHICGWVMAFFEALLDFCTRHWEPLKDTIKAYHRRRVWVNLAVVFVSALSLGLLLYLVVLRAPSAVPVMRTSERQSFVEACDRQFVDDQRRWEARMEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CW65</accession>
    <name>A0A177CW65_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative Hsp70 family chaperone</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1224615</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG11476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041841.1">
        <property type="nucleotide sequence ID" value="XM_018183544.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CW65"/>
    <dbReference type="STRING" id="1460663.A0A177CW65"/>
    <dbReference type="GeneID" id="28767030"/>
    <dbReference type="InParanoid" id="A0A177CW65"/>
    <dbReference type="OrthoDB" id="2963168at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10170">
        <property type="entry name" value="ASKHA_NBD_HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187">
        <property type="entry name" value="ALPHA KINASE/ELONGATION FACTOR 2 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187:SF5">
        <property type="entry name" value="HEAT SHOCK 70 KDA PROTEIN 12A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG11476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="558" mass="62602" checksum="79CA548269515160" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CW86</accession>
    <name>A0A177CW86_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_7976</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG11298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041663.1">
        <property type="nucleotide sequence ID" value="XM_018187443.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CW86"/>
    <dbReference type="GeneID" id="28770929"/>
    <dbReference type="InParanoid" id="A0A177CW86"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="138"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="160"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG11298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="238" mass="25743" checksum="0E35E5EAEA729BCD" modified="2016-09-07" version="1">MHHRHQRLRPTNGVPDHSHAPSIPKYDINFGDIPLQVPASFAVFVFLNWNLRLRIFIIILQASIIARNHGILQLHPTLLPPRPAQDHNSPNPTPRHSPPKPPTRNRPPSPQPRRHNPPPSALPPHRTPDTRPLPRNVPPSAATPHASHPTRRHHHAELGPRNPAAESRPPAAPSGAHDNVQHDAAGRGRCEWARAVRAGASGDGSSPDDNVRCEPLSCGAGGVGDAVFGGEWGGARGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CWB8</accession>
    <name>A0A177CWB8_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1158787</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG11192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041557.1">
        <property type="nucleotide sequence ID" value="XM_018177070.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CWB8"/>
    <dbReference type="GeneID" id="28760556"/>
    <dbReference type="InParanoid" id="A0A177CWB8"/>
    <dbReference type="OrthoDB" id="3690848at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG11192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="480" mass="55111" checksum="3B5557C4071D5275" modified="2016-09-07" version="1">MANQPTMPSSRDILLPTELTDFFFAEGDESEHFPAIFLYTIWPILLVLIYPTLFIVFLIEGIVELVFVCWLKTRGLLDLHPLSTEGTPLLASEDRAEVASRRNTVATRYPAVDVAAIDLSELKHGAQISSLPVRLVEMPMEDPSHIAVVSWRWDFSQPNTLSSGLSLNVAQAIKYAKAHGIHFLFIDIISLDQNLSPEELIPEVARFSTLYETIPVIAAYDDTRLDFEYIMIRPWIFSEIKKMMRNPHKIVYVGHLRQGTYICKSVLHWWLGRVPRHRMADTRFLNQLRKAWFADYVPPVLALLNGHNNMTDIHDFKFIIPPLAEAFTAAEKLPPNDYLLTIALLLSNSQWGGIREYDVEGAFLGLPYTKYQVRSFVSNKERAMTSADNYTVKHIEHTEMHEIRLGDEKIATFSYRHDHWKDTLVPRYTVTVDLHIRRRLLGMLELDTDDARYAISDDDMVGYFLGSTLSESQNIEVVEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CWT9</accession>
    <name>A0A177CWT9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1200770</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG11508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041873.1">
        <property type="nucleotide sequence ID" value="XM_018181681.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CWT9"/>
    <dbReference type="STRING" id="1460663.A0A177CWT9"/>
    <dbReference type="GeneID" id="28765167"/>
    <dbReference type="InParanoid" id="A0A177CWT9"/>
    <dbReference type="OrthoDB" id="3691966at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="588"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="630"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="308"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="371"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="158"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG11508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="655" mass="72891" checksum="2EDA9080103B6EF0" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CXF4</accession>
    <name>A0A177CXF4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">UPF0157-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_40667</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG11582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041947.1">
        <property type="nucleotide sequence ID" value="XM_018186068.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CXF4"/>
    <dbReference type="GeneID" id="28769554"/>
    <dbReference type="InParanoid" id="A0A177CXF4"/>
    <dbReference type="OrthoDB" id="630895at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007344">
        <property type="entry name" value="GrpB/CoaE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34822">
        <property type="entry name" value="GRPB DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G01530)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34822:SF1">
        <property type="entry name" value="GRPB FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04229">
        <property type="entry name" value="GrpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="191"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG11582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="351" mass="39497" checksum="24BC736FF29655CF" modified="2016-09-07" version="1">MSVEVHPHNPAWSSQFLAIKERLERLLKDVPYKSIEHVGSTSVPGLVAKPIIDIDIIVARNHVQTTLATLTAAGFTDMGELGIKDRWCVKDPEQEPKRNVYVCVEGAIQTRNHLALRDTLRRDEKLRNHYAHVKLGLAAKGVDIVEYVEGKSAIIEKILRAAGTLSEEDMGAVSKANKRGERIGAIKTERLVLREFVWGDVEAYFGLESREEVVRYQNWGPRTREQVGEQVAEIVKGSAAVPRTHFELAVEHEGRFIGRVGAKVKKDGIAHADLWFSFLPECQGRGFATEAMKAFIPLLSGPLELEIECDPRNTGSWKLAERLGFERFELTEKAFECKGEWVDSLVYRKQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CXG2</accession>
    <name>A0A177CXG2_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">GPI mannosyltransferase 2</fullName>
            <ecNumber evidence="12">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CC84DRAFT_1077754</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Endoplasmic reticulum membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the PIGV family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="12"/>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042610.1">
        <property type="nucleotide sequence ID" value="XM_018173772.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CXG2"/>
    <dbReference type="FunCoup" id="A0A177CXG2">
        <property type="interactions" value="292"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CXG2"/>
    <dbReference type="GeneID" id="28757258"/>
    <dbReference type="InParanoid" id="A0A177CXG2"/>
    <dbReference type="OrthoDB" id="10252502at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031501">
        <property type="term" value="C:mannosyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000009">
        <property type="term" value="F:alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004376">
        <property type="term" value="F:GPI mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007315">
        <property type="entry name" value="PIG-V/Gpi18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12468">
        <property type="entry name" value="GPI MANNOSYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12468:SF2">
        <property type="entry name" value="GPI MANNOSYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04188">
        <property type="entry name" value="Mannosyl_trans2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 12 14" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5 12" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <keyword evidence="7 12 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008058711" description="GPI mannosyltransferase 2" evidence="13">
        <location>
            <begin position="27"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="114"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="149"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="226"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="255"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="316"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="431"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OAG12245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="454" mass="50697" checksum="56ECCDF59345F81A" modified="2016-09-07" version="1">MASRNPSTRLIQAFFAWKSVLFIVAAFSPGPGYDTSALIASNPTSSRHVDFHSWPVIDRVSLNFFRWDALYFVKSAQRGYHYEQEWAFSWAYSLLLKTLVKLVSGDESISLQNYVWAGIIVSNACHLVSVVVLHRLSSLVLDRRHSGRVPFVAAMLHIVSPAGMFLSSPYAESLFAALNFTGMLLYAQARITDRPGRKQTVREDALILGAGVLFMLATWIRSNGLLSGILFLFDVVPFVSRLLDRELSLNDIRKLVITCSSGALLGLGSIGPQYVAYQQYCVSQAGPSLRPWCSKTIPSIYTWVQRYYWNVGFLRYWTFSNLPLFLMAGPMLWLLLQTGIDYLRNSSQQPLGPSKTQPRGEGKDINEASTGLPQLALPQLILAITAATNFHVQVINRLSSGYPVWYIATSGWMIARESVAQKTKVFEGSKWICRGLIIYALVQGSLFANFLPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CYU4</accession>
    <name>A0A177CYU4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_1226287</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042603.1">
        <property type="nucleotide sequence ID" value="XM_018183586.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CYU4"/>
    <dbReference type="FunCoup" id="A0A177CYU4">
        <property type="interactions" value="72"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CYU4"/>
    <dbReference type="GeneID" id="28767072"/>
    <dbReference type="InParanoid" id="A0A177CYU4"/>
    <dbReference type="OrthoDB" id="1928087at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.900.10">
        <property type="entry name" value="HORMA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003511">
        <property type="entry name" value="HORMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036570">
        <property type="entry name" value="HORMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051294">
        <property type="entry name" value="HORMA_MeioticProgression"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48225">
        <property type="entry name" value="HORMA DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48225:SF7">
        <property type="entry name" value="MEIOSIS-SPECIFIC PROTEIN HOP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02301">
        <property type="entry name" value="HORMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56019">
        <property type="entry name" value="The spindle assembly checkpoint protein mad2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50815">
        <property type="entry name" value="HORMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0469">Meiosis</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HORMA" evidence="7">
        <location>
            <begin position="68"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="355"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="422"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="626"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="25"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="46"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="359"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="436"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="450"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="667"/>
            <end position="683"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAG12238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="683" mass="76448" checksum="CBF66CCD47C52961" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CZI8</accession>
    <name>A0A177CZI8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">p-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CC84DRAFT_1183165</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042906.1">
        <property type="nucleotide sequence ID" value="XM_018180670.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CZI8"/>
    <dbReference type="FunCoup" id="A0A177CZI8">
        <property type="interactions" value="913"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CZI8"/>
    <dbReference type="GeneID" id="28764156"/>
    <dbReference type="InParanoid" id="A0A177CZI8"/>
    <dbReference type="OrthoDB" id="2110130at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03221">
        <property type="entry name" value="ABCF_EF-3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000104">
        <property type="entry name" value="ATP-binding cassette sub-family F member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000882">
        <property type="entry name" value="Translation initiation regulator (Gcn20)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032781">
        <property type="entry name" value="ABC_tran_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050611">
        <property type="entry name" value="ABCF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211:SF117">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY F MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211">
        <property type="entry name" value="ATP-BINDING TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12848">
        <property type="entry name" value="ABC_tran_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="201"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="533"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="762"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="125"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="284"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="806"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="822"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="851"/>
            <end position="864"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAG12541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="1224" mass="134594" checksum="7BB25E0361AD8D04" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CZM2</accession>
    <name>A0A177CZM2_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1135242</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042883.1">
        <property type="nucleotide sequence ID" value="XM_018176054.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CZM2"/>
    <dbReference type="STRING" id="1460663.A0A177CZM2"/>
    <dbReference type="GeneID" id="28759540"/>
    <dbReference type="InParanoid" id="A0A177CZM2"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052635">
        <property type="entry name" value="Sec_Metab_Biosynth_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39607:SF1">
        <property type="entry name" value="B-ZIP TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39607">
        <property type="entry name" value="XANTHOCILLIN BIOSYNTHESIS CLUSTER TRANSCRIPTION FACTOR XANC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="2">
        <location>
            <begin position="46"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="255"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG12518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="265" mass="29559" checksum="77AF4DC554D7A38D" modified="2016-09-07" version="1">MHRHAGYQYAAAPAAPTHRYSGTSSAFSASANPNEDWTKISDLAERRRIQNRIAQRNYRKKLKKRLEDLERRAASSSASPEQKPAELQPTQPSARQAFPSPASSESDFSRRTPEMQSYEERGMFSHQYTDRQLSTSPPPFSYSAYPTPESAAYPVPYTTTATPYHSIPTTISPEMTTYAYLPPLSAAYPPTLPSLAPPMKSEYYQEDDIANPFASGYQLMNSMEIPPPHAYPPSDAHANSPPEMYQPTTPDSMPRTPPMHPIPGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CZN1</accession>
    <name>A0A177CZN1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1159870</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042946.1">
        <property type="nucleotide sequence ID" value="XM_018177350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CZN1"/>
    <dbReference type="GeneID" id="28760836"/>
    <dbReference type="InParanoid" id="A0A177CZN1"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG12581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="61" mass="6055" checksum="B7AB9D8A11E57361" modified="2016-09-07" version="1">MPVCTSRPPQHCPCPEAATIPASAGQSGGPLEAQSVLPLKLALAAATAVAVLCMIAATRQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177D0I6</accession>
    <name>A0A177D0I6_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 11">Dihydroorotate dehydrogenase (fumarate)</fullName>
            <ecNumber evidence="11">1.3.98.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Dihydroorotate oxidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CC84DRAFT_1183463</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the conversion of dihydroorotate to orotate with fumarate as the electron acceptor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>(S)-dihydroorotate + fumarate = orotate + succinate</text>
            <dbReference type="Rhea" id="RHEA:30059"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:30839"/>
            <dbReference type="ChEBI" id="CHEBI:30864"/>
            <dbReference type="EC" id="1.3.98.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 11">Pyrimidine metabolism; UMP biosynthesis via de novo pathway.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 11">Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.3.98.1" evidence="11"/>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018043326.1">
        <property type="nucleotide sequence ID" value="XM_018180688.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177D0I6"/>
    <dbReference type="FunCoup" id="A0A177D0I6">
        <property type="interactions" value="702"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177D0I6"/>
    <dbReference type="GeneID" id="28764174"/>
    <dbReference type="InParanoid" id="A0A177D0I6"/>
    <dbReference type="OrthoDB" id="14784at2759"/>
    <dbReference type="UniPathway" id="UPA00070"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990663">
        <property type="term" value="F:dihydroorotate dehydrogenase (fumarate) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04741">
        <property type="entry name" value="DHOD_1A_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.26.10">
        <property type="entry name" value="Dihydroorotate Dehydrogenase A, chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050074">
        <property type="entry name" value="DHO_dehydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033886">
        <property type="entry name" value="DHOD_1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023359">
        <property type="entry name" value="Dihydro_DH_chainA_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005720">
        <property type="entry name" value="Dihydroorotate_DH_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48109:SF1">
        <property type="entry name" value="DIHYDROOROTATE DEHYDROGENASE (FUMARATE)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48109">
        <property type="entry name" value="DIHYDROOROTATE DEHYDROGENASE (QUINONE), MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01180">
        <property type="entry name" value="DHO_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 11" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8 11" id="KW-0288">FMN</keyword>
    <keyword evidence="10 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9 11" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dihydroorotate dehydrogenase catalytic" evidence="12">
        <location>
            <begin position="68"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU364042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OAG12961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="368" mass="39162" checksum="F1307C06263B3B68" modified="2016-09-07" version="1">MDAHSKSLHIEPPLLNSANPWCSTLEQLQELYDCPSTGAVTTRTSLLEGFPNDEKIHQFAFFSPSTHEAGSANPTGQETADASGSLNTLGYSPLPLKQYLGFIKTISDHMTGTSTSTSRIKPFIVSVTGAVEEVVECYRQIHEQQNHVRMALAMEVNLSCPNIPGKPPPAYSSKALLAYLAALKQEIARQVEPVLPGKHTHVGTTHVPIGIKTPPYTYHDQYQAMIDALLGSAKAEPAHLPCPISFITATNTLGSSLLLHPIAEPTASSPAPHEYYHHVLNSANGTGIGGLAGAPLHPIALGNVYTIKGLLFQHDELSQIQIIGVGGVEDAEGYKRMRAVGATAVGVGTALGRKGVQAFADIAKGLRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177D1C6</accession>
    <name>A0A177D1C6_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ATP citrate synthase</fullName>
            <ecNumber evidence="2">2.3.3.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">ATP-citrate (pro-S-)-lyase 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Citrate cleavage enzyme subunit 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">CC84DRAFT_1079898</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes the formation of cytosolic acetyl-CoA, which is mainly used for the biosynthesis of fatty acids and sterols.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>oxaloacetate + acetyl-CoA + ADP + phosphate = citrate + ATP + CoA</text>
            <dbReference type="Rhea" id="RHEA:21160"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16947"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.3.3.8"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="15">Composed of two subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the succinate/malate CoA ligase alpha subunit family.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.8" evidence="2"/>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018043295.1">
        <property type="nucleotide sequence ID" value="XM_018173866.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177D1C6"/>
    <dbReference type="STRING" id="1460663.A0A177D1C6"/>
    <dbReference type="GeneID" id="28757352"/>
    <dbReference type="InParanoid" id="A0A177D1C6"/>
    <dbReference type="OrthoDB" id="3261737at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003878">
        <property type="term" value="F:ATP citrate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006085">
        <property type="term" value="P:acetyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06100">
        <property type="entry name" value="CCL_ACL-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.261:FF:000003">
        <property type="entry name" value="ATP-citrate synthase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.230.10:FF:000005">
        <property type="entry name" value="ATP-citrate synthase subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000024">
        <property type="entry name" value="Probable ATP-citrate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.580.10">
        <property type="entry name" value="Citrate Synthase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.230.10">
        <property type="entry name" value="Cytochrome P450-Terp, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017440">
        <property type="entry name" value="Cit_synth/succinyl-CoA_lig_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016142">
        <property type="entry name" value="Citrate_synth-like_lrg_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016143">
        <property type="entry name" value="Citrate_synth-like_sm_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002020">
        <property type="entry name" value="Citrate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036969">
        <property type="entry name" value="Citrate_synthase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033847">
        <property type="entry name" value="Citrt_syn/SCS-alpha_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017866">
        <property type="entry name" value="Succ-CoA_synthase_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005811">
        <property type="entry name" value="SUCC_ACL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23118">
        <property type="entry name" value="ATP-CITRATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23118:SF42">
        <property type="entry name" value="ATP-CITRATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00285">
        <property type="entry name" value="Citrate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02629">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00549">
        <property type="entry name" value="Ligase_CoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00881">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48256">
        <property type="entry name" value="Citrate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01216">
        <property type="entry name" value="SUCCINYL_COA_LIG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00399">
        <property type="entry name" value="SUCCINYL_COA_LIG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01217">
        <property type="entry name" value="SUCCINYL_COA_LIG_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CoA-binding" evidence="19">
        <location>
            <begin position="46"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="10"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00054002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00060724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00062455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00076189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00083544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="SMART" id="SM00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="OAG12930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="668" mass="72537" checksum="7B3AEE028FE2C6A1" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BU09</accession>
    <name>A0A177BU09_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BEM46 family protein-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1158307</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441564">
        <property type="protein sequence ID" value="OAF98744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029110.1">
        <property type="nucleotide sequence ID" value="XM_018177044.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BU09"/>
    <dbReference type="FunCoup" id="A0A177BU09">
        <property type="interactions" value="636"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177BU09"/>
    <dbReference type="ESTHER" id="9pleo-a0a177bu09">
        <property type="family name" value="ABHD13-BEM46"/>
    </dbReference>
    <dbReference type="GeneID" id="28760530"/>
    <dbReference type="InParanoid" id="A0A177BU09"/>
    <dbReference type="OrthoDB" id="10249433at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008474">
        <property type="term" value="F:palmitoyl-(protein) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277">
        <property type="entry name" value="ALPHA/BETA HYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277:SF81">
        <property type="entry name" value="PROTEIN ABHD13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="domain" description="Serine aminopeptidase S33" evidence="2">
        <location>
            <begin position="91"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAF98744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="296" mass="32752" checksum="DE52BA12A73BE2D4" modified="2016-09-07" version="1">MGGALDSFLSYLRVPLIASSGIAALLSGVLYFKQNEIIYARNFPPDARTNVPRPAQFGIPDFEELFIPTPDGESLSAFYIRANRAQSRNVTLLMFHGNAGNIGYRLPIAKVLAEEMGCNVFMLQYRGYGLSTGTPNEKGINIDAQTGLDYIRNRHELRSTRVVLYGQSLGGAVSIGLGARNQKQGDIAGIILENTFTSMRKMIPSALPPAKYLAPFCHQVWPSEDTLPQIINIPILFLSGLRDEIVPPSHMSKLYQVCRSTPKVWRELPNGTHNDSVSEPGYFAYIDEFLSEHVGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BU23</accession>
    <name>A0A177BU23_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1105411</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441564">
        <property type="protein sequence ID" value="OAF98675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029041.1">
        <property type="nucleotide sequence ID" value="XM_018175095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BU23"/>
    <dbReference type="GeneID" id="28758581"/>
    <dbReference type="InParanoid" id="A0A177BU23"/>
    <dbReference type="OrthoDB" id="5418749at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42030">
        <property type="entry name" value="DRBM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42030:SF1">
        <property type="entry name" value="DRBM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAF98675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="84" mass="9764" checksum="B2C88137BC1D710D" modified="2016-09-07" version="1" fragment="single">YCTANQIAQPQFQDYSDPRGIRTAWSSGVVVQGREFRAHLWRDYRYLEQSREEAAEIAWKTLNGIPVTNAPQFTYGRGYTTMSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BUN1</accession>
    <name>A0A177BUN1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF3500 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1130879</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441562">
        <property type="protein sequence ID" value="OAF99173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029539.1">
        <property type="nucleotide sequence ID" value="XM_018175875.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BUN1"/>
    <dbReference type="STRING" id="1460663.A0A177BUN1"/>
    <dbReference type="GeneID" id="28759361"/>
    <dbReference type="InParanoid" id="A0A177BUN1"/>
    <dbReference type="OrthoDB" id="4539697at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021889">
        <property type="entry name" value="DUF3500"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37489">
        <property type="entry name" value="DUF3500 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37489:SF1">
        <property type="entry name" value="DUF3500 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12006">
        <property type="entry name" value="DUF3500"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAF99173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="431" mass="49085" checksum="ABD830C55A1B520C" modified="2016-09-07" version="1">MPSTLHRMSSFEEASAAFRAHLPDLATPRFTTAAEQDVYEYAKFFQDNHAPPWLFELTQAWAKLYEEPFKGVTSDGNVKEGLYEARDEGIDIESIVKKAEDLLSKLDEQQSKKLKYPVNAKEWRAWSNPEILLRPFGLRLEEVPEATNDAIHKVIEASLSPEGYQKALASMRINHFLGECVKLPKIMNKDSYNFLLFGTPSASPSSPWGWLLYGHHLDIACFFRGPQITISPTFTGAEPNIIDAGPWKGTEILHKKGNIGLKLMQSLTSEQQQTAQIYKNLRDDGMKQTGDLATDRWNKDDQRHLCGAFRDNRIVPYEGVTVSSLTPDQQSLVLEIAEEMLLYLPTKSRQLRLDQIKSHFEETYFSWIGGYGDDDAFYYRIQSPVVILEFDHHSGVFLSNTEPKKFHTHTIVRTPNAGDYGQAIRATEHRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2023-06-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BVV5</accession>
    <name>A0A177BVV5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_608671</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441578">
        <property type="protein sequence ID" value="OAF98459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018028825.1">
        <property type="nucleotide sequence ID" value="XM_018186868.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BVV5"/>
    <dbReference type="GeneID" id="28770354"/>
    <dbReference type="InParanoid" id="A0A177BVV5"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAF98459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="58" mass="6444" checksum="7B225DEB2F971E67" modified="2016-09-07" version="1">MPGDFDENTSVPDGYMRSPSSVPLADREIAIMGPKLSLIPMRMPDESLLIASHIRWDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BWW2</accession>
    <name>A0A177BWW2_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1190723</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441560">
        <property type="protein sequence ID" value="OAF99892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030258.1">
        <property type="nucleotide sequence ID" value="XM_018181136.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BWW2"/>
    <dbReference type="GeneID" id="28764622"/>
    <dbReference type="InParanoid" id="A0A177BWW2"/>
    <dbReference type="OrthoDB" id="3226064at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="3"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAF99892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="461" mass="52703" checksum="FFF21C8E91003FD3" modified="2016-09-07" version="1">MELLELYYDVLIKIIEEVEPEDLAALAQTSIGFNHFVKGNEMLYKAHYLKNFDDPRRRPTDPAPDWIAELQRLVKLRKILQSQSPDVKSANMDFVLETISTLIKTGTESEGLSLNCGELTKLFSNPQNADMFMHRSSLYRRAGMETQSQAQSLETRQQSARLHSIYGIPKDSTGRRTLSTHPFARSRVYDLRNYSKRSRWGPFRNDGSMRVDWELVESIMVVLGYNNGICSRRYMDRFVLPWSAPFANIFQDRFAHLPFTDLQPPLPSLTKEPSLPLDFQDPYNVSGIWARIVCFLDYDDLYDFNFNTTAVRTPEDQPLPPITMEEAVRHIMMHLEVTAVTAPGKNDNQTMPVIHFDGKARAVDTNMDANANSSIRGCVRMTPEGEVRWSTVWIFNGHEERWRSEAIQVGGLRSKRGVVGVWYDKSFDPHGPAGPTAFWKVKELASGTDEDGNDSDDFMEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BXP3</accession>
    <name>A0A177BXP3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Antigenic cell wall galactomanno protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1199541</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441560">
        <property type="protein sequence ID" value="OAF99895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030261.1">
        <property type="nucleotide sequence ID" value="XM_018181625.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BXP3"/>
    <dbReference type="GeneID" id="28765111"/>
    <dbReference type="InParanoid" id="A0A177BXP3"/>
    <dbReference type="OrthoDB" id="2422134at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021054">
        <property type="entry name" value="Cell_wall_mannoprotein_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38123">
        <property type="entry name" value="CELL WALL SERINE-THREONINE-RICH GALACTOMANNOPROTEIN MP1 (AFU_ORTHOLOGUE AFUA_4G03240)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38123:SF1">
        <property type="entry name" value="HYDROPHOBIC SURFACE BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12296">
        <property type="entry name" value="HsbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012249652" description="Antigenic cell wall galactomanno protein" evidence="1">
        <location>
            <begin position="16"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAF99895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="182" mass="19034" checksum="F6D0C42435FADE17" modified="2016-09-07" version="1">MRFTPVLSLLPFALALPRIPRDAASLAPQVLEQIATLNSSLTSLTTAVNAFDGTLLHVIPQSLAVITAETALDAATLKTTFITKSSGNFTQTESNSVVAGLANLIAPIQTSLTALSAKYEVFKKTLESPIVLLDLKILKAHTDDLIDAVTAKVVPASAGLLGFGKGIIDKAFDDAIAVYQGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BZ95</accession>
    <name>A0A177BZ95_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HPC2-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1169267</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441561">
        <property type="protein sequence ID" value="OAF99766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030132.1">
        <property type="nucleotide sequence ID" value="XM_018179619.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BZ95"/>
    <dbReference type="STRING" id="1460663.A0A177BZ95"/>
    <dbReference type="GeneID" id="28763105"/>
    <dbReference type="InParanoid" id="A0A177BZ95"/>
    <dbReference type="OrthoDB" id="5576775at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014840">
        <property type="entry name" value="HRD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08729">
        <property type="entry name" value="HUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hpc2-related" evidence="2">
        <location>
            <begin position="464"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="428"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="509"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="242"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="283"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="314"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="341"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="534"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="558"/>
            <end position="568"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAF99766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="601" mass="62573" checksum="779E5CB4A0CC344A" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BZC1</accession>
    <name>A0A177BZC1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1263322</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441559">
        <property type="protein sequence ID" value="OAG00331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030696.1">
        <property type="nucleotide sequence ID" value="XM_018185228.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BZC1"/>
    <dbReference type="GeneID" id="28768714"/>
    <dbReference type="InParanoid" id="A0A177BZC1"/>
    <dbReference type="OrthoDB" id="10306384at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008057526" evidence="1">
        <location>
            <begin position="19"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG00331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="175" mass="19809" checksum="81FF63AE161FA766" modified="2016-09-07" version="1">MRFLTLAVTLMQVVIGVARPIDEPAPPAFMIMTAREPGTQGTQGTTNLPNYDMLILHIDTNQRGQWYHIDRIMVKYSTCMAWIDVDKLGGISSLESFKNQQGLPFYCFNYASTDCSGDTYWWKGVIRLDSLPSNWDNKIRSTRCHHGRFPDDIPPPDAKREEATLLVGSTTHEPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C0A1</accession>
    <name>A0A177C0A1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">L-serine ammonia-lyase</fullName>
            <ecNumber evidence="5">4.3.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CC84DRAFT_281648</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-serine = pyruvate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:19169"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="EC" id="4.3.1.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the serine/threonine dehydratase family.</text>
    </comment>
    <dbReference type="EC" id="4.3.1.17" evidence="5"/>
    <dbReference type="EMBL" id="KV441559">
        <property type="protein sequence ID" value="OAG00272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030637.1">
        <property type="nucleotide sequence ID" value="XM_018185761.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C0A1"/>
    <dbReference type="FunCoup" id="A0A177C0A1">
        <property type="interactions" value="457"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177C0A1"/>
    <dbReference type="GeneID" id="28769247"/>
    <dbReference type="InParanoid" id="A0A177C0A1"/>
    <dbReference type="OrthoDB" id="7773036at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003941">
        <property type="term" value="F:L-serine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004794">
        <property type="term" value="F:threonine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006565">
        <property type="term" value="P:L-serine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006567">
        <property type="term" value="P:L-threonine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000040">
        <property type="entry name" value="L-serine dehydratase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050147">
        <property type="entry name" value="Ser/Thr_Dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000634">
        <property type="entry name" value="Ser/Thr_deHydtase_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48078:SF2">
        <property type="entry name" value="CATABOLIC L-SERINE_THREONINE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48078">
        <property type="entry name" value="THREONINE DEHYDRATASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00165">
        <property type="entry name" value="DEHYDRATASE_SER_THR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="9" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="11">
        <location>
            <begin position="19"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OAG00272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="383" mass="41548" checksum="A48498EE594BEC42" modified="2016-09-07" version="1">MGVNEFLQSSQEQSRPWVETPLRESYALSQAAGCRIFLKLETLQPSGSFKSRGIGHYLVKRVEELPAHINNPHIFCSSGGNAGLAAVHASRTLGVACTVVVPLTVKQLMVTKIKAAGAYEVLQHGDAWADADKYMREELMPQAGEAAIYAPPFDHPDIWAGNSSIMYEIATQMPDSPADAIICSVGGGGLLNGIAMALDDLRLSDSTTVVGVETAGAESLAAAVRAGQLVTLPRITSQATSLGCARVTQLTLDTAQRQNFKGVVLPDAEAAMGCWRLADDERIMVELACGVNVALCYDGRLEKALGRKVRPDEKIVIVLCGGSNVTVNMLSEWRKEYAYLEEPVVRKEDAKVQDLPEEVPEIPRRAPVHRQWNEEVLQLEAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C0D6</accession>
    <name>A0A177C0D6_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_1101434</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441558">
        <property type="protein sequence ID" value="OAG01254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031619.1">
        <property type="nucleotide sequence ID" value="XM_018174914.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C0D6"/>
    <dbReference type="STRING" id="1460663.A0A177C0D6"/>
    <dbReference type="GeneID" id="28758400"/>
    <dbReference type="InParanoid" id="A0A177C0D6"/>
    <dbReference type="OrthoDB" id="4937900at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053157">
        <property type="entry name" value="Sterol_Uptake_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47784">
        <property type="entry name" value="STEROL UPTAKE CONTROL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47784:SF4">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="28"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="16"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAG01254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="395" mass="44598" checksum="2D5C7A40D6AFBE64" modified="2016-09-07" version="1">MSTPIDEAETPEQQRAAKRKTHRKSRNGCFQCKQRHTKCNEEHPRCGNCVRLDIHCTWPSRERFSTKYPTPPESHAVATAERTLSVGPDVPVSSFGSPMSIADLRLLHHWSTKSYQDMNADPARWPAWQIDCVEVAFDFPFLLRGILALAAIHKTSCDPQADRQSLLLQADTHISSALETYRKNLEHPSEETAMAMFLLSMVIVTYNLASAQLEAPEDPIGALHHCFRLVQGVALVIQPHVTQIMNSKMMSKIVEQGPGITFEGKVPEVLRLKKLAETKRTSAHDFYTLAIDDLHTHFLKTRQCPPENDRLAIAFSWSSHLSEEFLHLISTHDPITALVLAHFAVLLTECRLAWWIAEWPLRIVLAAQKLLVATPELLAYLDWPLEIVKASAGER</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C0F2</accession>
    <name>A0A177C0F2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Clavaminate synthase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_1190682</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441559">
        <property type="protein sequence ID" value="OAG00711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031076.1">
        <property type="nucleotide sequence ID" value="XM_018181128.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C0F2"/>
    <dbReference type="STRING" id="1460663.A0A177C0F2"/>
    <dbReference type="GeneID" id="28764614"/>
    <dbReference type="InParanoid" id="A0A177C0F2"/>
    <dbReference type="OrthoDB" id="288590at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044283">
        <property type="term" value="P:small molecule biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050231">
        <property type="entry name" value="Iron_ascorbate_oxido_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47990">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00682">
        <property type="entry name" value="IPNSYNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="3">
        <location>
            <begin position="211"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAG00711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="369" mass="42139" checksum="5D878596BC0FD9FD" modified="2016-09-07" version="1">MSSTETETQEETYVSYHDGGVFGKRRVLTGKAAKPTFNAVPKIDMRRIYSDNLDDRKELAKEVGDACRNVGFFYAVNHGVEEQILDDTFSAVKRFFDLPTEVKMEVHNQKTEKFRGYEAFLEGKLDPSTRGDLKEGFLMGEDATDPEQKLPVRDLPFMSTPRNQWPSHPTATFFRPALYTYYTAMLTFSRRLLGIFALALDLPEHHFDTITRHPMTNVRAVHYPPQHSDADVGIGAHTDFCWFTLVCQSRTEYPALEVLNANGIWVPVSHEPHSFVVNIADFLKLVTGGEWMSTVHRVRNMGGEERYSMPFFFSPDEDARVSVLERYSKKGGMYEEFGVGEYFQKRLVVDRRTHLEGAEGGEVKRSAGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C0T9</accession>
    <name>A0A177C0T9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Zinc finger C2H2 LYAR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CC84DRAFT_1180360</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the UPF0743 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441559">
        <property type="protein sequence ID" value="OAG00327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030692.1">
        <property type="nucleotide sequence ID" value="XM_018180470.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C0T9"/>
    <dbReference type="STRING" id="1460663.A0A177C0T9"/>
    <dbReference type="GeneID" id="28763956"/>
    <dbReference type="InParanoid" id="A0A177C0T9"/>
    <dbReference type="OrthoDB" id="21474at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.490:FF:000001">
        <property type="entry name" value="cell growth-regulating nucleolar protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039999">
        <property type="entry name" value="LYAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014898">
        <property type="entry name" value="Znf_C2H2_LYAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13100:SF10">
        <property type="entry name" value="CELL GROWTH-REGULATING NUCLEOLAR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13100">
        <property type="entry name" value="CELL GROWTH-REGULATING NUCLEOLAR PROTEIN LYAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08790">
        <property type="entry name" value="zf-LYAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51804">
        <property type="entry name" value="ZF_C2HC_LYAR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Zinc finger C2H2 LYAR-type" evidence="10">
        <location>
            <begin position="30"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="64"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="192"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="291"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="204"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="222"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="338"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="397"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00061084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OAG00327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="545" mass="62572" checksum="95F2B4E86358E4DA" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C155</accession>
    <name>A0A177C155_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CC84DRAFT_1262580</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV441557">
        <property type="protein sequence ID" value="OAG01524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031889.1">
        <property type="nucleotide sequence ID" value="XM_018185159.1"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177C155"/>
    <dbReference type="GeneID" id="28768645"/>
    <dbReference type="InParanoid" id="A0A177C155"/>
    <dbReference type="OrthoDB" id="245989at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03233">
        <property type="entry name" value="ABCG_PDR_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03232">
        <property type="entry name" value="ABCG_PDR_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001601">
        <property type="entry name" value="ABC multidrug transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000054">
        <property type="entry name" value="ABC multidrug transporter atrF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029481">
        <property type="entry name" value="ABC_trans_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043926">
        <property type="entry name" value="ABCG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034001">
        <property type="entry name" value="ABCG_PDR_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034003">
        <property type="entry name" value="ABCG_PDR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010929">
        <property type="entry name" value="PDR_CDR_ABC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19241">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19055">
        <property type="entry name" value="ABC2_membrane_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14510">
        <property type="entry name" value="ABC_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06422">
        <property type="entry name" value="PDR_CDR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="547"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="576"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="618"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="653"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="683"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="790"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1207"/>
            <end position="1227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1239"/>
            <end position="1262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1282"/>
            <end position="1310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1322"/>
            <end position="1345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1351"/>
            <end position="1369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1475"/>
            <end position="1494"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="15">
        <location>
            <begin position="179"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="15">
        <location>
            <begin position="870"/>
            <end position="1112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="833"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1501"/>
            <end position="1534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="46"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="58"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1519"/>
            <end position="1534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OAG01524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="1534" mass="171470" checksum="39637908CB0F4A26" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2023-06-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C1P8</accession>
    <name>A0A177C1P8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_211818</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441557">
        <property type="protein sequence ID" value="OAG01704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032069.1">
        <property type="nucleotide sequence ID" value="XM_018185603.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C1P8"/>
    <dbReference type="GeneID" id="28769089"/>
    <dbReference type="InParanoid" id="A0A177C1P8"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG01704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="76" mass="8597" checksum="D80CAAF24BB4EE4E" modified="2016-09-07" version="1">MQCYRLSVIKDMHRKHLGRIGAMLSLSDRRRAIAIRRSKTCIRTGATLSLGGRSKTCILVIFNIQGGLLFSLRWHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C1X3</accession>
    <name>A0A177C1X3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1168049</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441558">
        <property type="protein sequence ID" value="OAG00818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031183.1">
        <property type="nucleotide sequence ID" value="XM_018179309.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C1X3"/>
    <dbReference type="STRING" id="1460663.A0A177C1X3"/>
    <dbReference type="GeneID" id="28762795"/>
    <dbReference type="InParanoid" id="A0A177C1X3"/>
    <dbReference type="OrthoDB" id="1263307at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052897">
        <property type="entry name" value="Sec-Metab_Biosynth_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37017:SF13">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37017">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="10"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG00818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="255" mass="27930" checksum="E4473455D355E570" modified="2016-09-07" version="1">MSLTKSKPTILFVPGAWHLPSCYDLVSAPLSAAGYSTVSVALPSNSHNPVPSFEPDISAIRAALAPLVEAGKDVVVVAHSYGSVPANEAIKGLTRREREARGEQGGVVHYVFLSAFITPVGVSLMDALQNKDLPWFIVQEDKTLVRPDNPREIFYGDLSDDEAKKWEERLVPFSYQCYFGKTEFAAYREVESTFVFCTEDRAIPIQVQEGMVAAAEQQRAKFGRVVLEGSSHSPMLSRPGEVVEVIKRVSEGLGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C234</accession>
    <name>A0A177C234_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1221307</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441557">
        <property type="protein sequence ID" value="OAG01844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032209.1">
        <property type="nucleotide sequence ID" value="XM_018183258.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C234"/>
    <dbReference type="GeneID" id="28766744"/>
    <dbReference type="InParanoid" id="A0A177C234"/>
    <dbReference type="OrthoDB" id="3788067at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="233"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="295"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="373"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="243"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="269"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="304"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="393"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="407"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="419"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG01844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="601" mass="66743" checksum="4EDD234D84010F72" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C274</accession>
    <name>A0A177C274_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CC84DRAFT_1100589</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441557">
        <property type="protein sequence ID" value="OAG01545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031910.1">
        <property type="nucleotide sequence ID" value="XM_018174873.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C274"/>
    <dbReference type="STRING" id="1460663.A0A177C274"/>
    <dbReference type="GeneID" id="28758359"/>
    <dbReference type="InParanoid" id="A0A177C274"/>
    <dbReference type="OrthoDB" id="3934549at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF157">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="19"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="115"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="173"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="207"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="249"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="14"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="316"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAG01545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="366" mass="41498" checksum="C7D753C337CE5081" modified="2016-09-07" version="1">MDCAIDLLTNSGSRYFCRWYRMGVIGATDHLMFIALVLTWGNTVVNYYQDQTSSKFRFSFFRKPDKRPQAVVALRGTLITWYVYRMLYGVALCFVKLSILFFYRNIASHRTFRRVVYGLIAFVIAYTFATTTAAAFQCQNPAGSFDVTGYLAQFDRDPNTKKKDYKCFDPTRLWLFTGAVNLFTDVLILLLPIPTLLGLRVPMNKRLALVSIFSVGIMAIVASCVRMWVMALWAESPQNSARFGCDLLLWGQVEVNSGIVSASVPFLRLFFRGREREPDEKPIARRKVREIAPPNLAQGDAKPLRMQSMEFFEQEKIRKRDEETGNDSRSPDSPEWGGFITVPASLSSGSRGSAMLETPVKAHTTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C287</accession>
    <name>A0A177C287_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Isocitrate dehydrogenase [NAD] subunit 2, mitochondrial</fullName>
            <ecNumber evidence="6">1.1.1.41</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Isocitric dehydrogenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">NAD(+)-specific ICDH</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CC84DRAFT_1128793</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-threo-isocitrate + NAD(+) = 2-oxoglutarate + CO2 + NADH</text>
            <dbReference type="Rhea" id="RHEA:23632"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.41"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Octamer of two non-identical subunits IDH1 and IDH2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the isocitrate and isopropylmalate dehydrogenases family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.41" evidence="6"/>
    <dbReference type="EMBL" id="KV441558">
        <property type="protein sequence ID" value="OAG01271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031636.1">
        <property type="nucleotide sequence ID" value="XM_018175811.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C287"/>
    <dbReference type="FunCoup" id="A0A177C287">
        <property type="interactions" value="864"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177C287"/>
    <dbReference type="GeneID" id="28759297"/>
    <dbReference type="InParanoid" id="A0A177C287"/>
    <dbReference type="OrthoDB" id="10261637at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045242">
        <property type="term" value="C:isocitrate dehydrogenase complex (NAD+)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004449">
        <property type="term" value="F:isocitrate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006102">
        <property type="term" value="P:isocitrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.718.10:FF:000003">
        <property type="entry name" value="Isocitrate dehydrogenase [NAD] subunit, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.718.10">
        <property type="entry name" value="Isopropylmalate Dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019818">
        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004434">
        <property type="entry name" value="Isocitrate_DH_NAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00175">
        <property type="entry name" value="mito_nad_idh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11835">
        <property type="entry name" value="DECARBOXYLATING DEHYDROGENASES-ISOCITRATE, ISOPROPYLMALATE, TARTRATE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11835:SF34">
        <property type="entry name" value="ISOCITRATE DEHYDROGENASE [NAD] SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53659">
        <property type="entry name" value="Isocitrate/Isopropylmalate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0520">NAD</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Isopropylmalate dehydrogenase-like" evidence="15">
        <location>
            <begin position="52"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00030683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00072026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OAG01271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="382" mass="41503" checksum="39D95BE4CC49BA7E" modified="2016-09-07" version="1">MLAGRAFAAPARQCLRRTTATSRWTPALVQSRTYASEVAKFKGQKGNDGKYTVTLIEGDGIGPEIAQSVKDIYSAANVPIKWEPVDVTPRLKDGKTVIPDEAIASVERNLVALKGPLATPVGKGHVSLNLTLRRTFNLFANVRPCRSIVGFKTPYDNVDTVLIRENTEGEYSGIEHVVVDGVVQSIKLITREASERVLRYAFQHARDIGRKKVRAVHKATIMKMSDGLFLSTARDVSKDFPDIEFDAELLDNTCLKMVTDPLPYNDKVLVMPNLYGDILSDMCAGLIGGLGLTPSGNIGDECSIFEAVHGSAPDIQGKQLANPTALLLSSMMMLRHMGLGDHANNIEQAIFKTIAEGKTITGDLGGKAKTYEYADAVIKALK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C2M4</accession>
    <name>A0A177C2M4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glutathione S-transferase protein-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_211469</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441557">
        <property type="protein sequence ID" value="OAG01695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032060.1">
        <property type="nucleotide sequence ID" value="XM_018185600.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C2M4"/>
    <dbReference type="STRING" id="1460663.A0A177C2M4"/>
    <dbReference type="GeneID" id="28769086"/>
    <dbReference type="InParanoid" id="A0A177C2M4"/>
    <dbReference type="OrthoDB" id="414243at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03192">
        <property type="entry name" value="GST_C_Sigma_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.10:FF:000051">
        <property type="entry name" value="Glutathione S-transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050213">
        <property type="entry name" value="GST_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11571">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11571:SF263">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14497">
        <property type="entry name" value="GST_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST N-terminal" evidence="1">
        <location>
            <begin position="6"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="2">
        <location>
            <begin position="105"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG01695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="259" mass="29257" checksum="F850388EB68D5961" modified="2016-09-07" version="1">MSNANKYELLYWPGIPGRGEFVRLAFEATKTPYLDVSNQVEGGIRQILALKDEKATYDADGNPPALAPPALRIHGEGKNGKALVLSQTPAILAFLGEKLDLAGADAAEKAWIQALALTALDLNNETHDTHHPVSTLAYYEDQKEESLRRATDFRESRIPKFFGYFERVLKGNKEGKGRYLVGDKLSYADLTLWQVVHGLKFAFPKELKAREEAGEFPTIFKTFFPSVPEHGQLKEYLDSDRRKPYSKGIFRHYPELDRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C323</accession>
    <name>A0A177C323_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">WW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_221947</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441557">
        <property type="protein sequence ID" value="OAG01796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032161.1">
        <property type="nucleotide sequence ID" value="XM_018185626.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C323"/>
    <dbReference type="STRING" id="1460663.A0A177C323"/>
    <dbReference type="GeneID" id="28769112"/>
    <dbReference type="InParanoid" id="A0A177C323"/>
    <dbReference type="OrthoDB" id="4850726at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF73">
        <property type="entry name" value="HET DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_8G01020)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WW" evidence="2">
        <location>
            <begin position="92"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG01796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="785" mass="89531" checksum="34725B4FAD220745" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C324</accession>
    <name>A0A177C324_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_201441</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441557">
        <property type="protein sequence ID" value="OAG01571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031936.1">
        <property type="nucleotide sequence ID" value="XM_018185571.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C324"/>
    <dbReference type="STRING" id="1460663.A0A177C324"/>
    <dbReference type="GeneID" id="28769057"/>
    <dbReference type="InParanoid" id="A0A177C324"/>
    <dbReference type="OrthoDB" id="5422351at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40625:SF1">
        <property type="entry name" value="AMP-ACTIVATED PROTEIN KINASE GLYCOGEN-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40625">
        <property type="entry name" value="GTP-BINDING PROTEIN ESDC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="263"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="402"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="539"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="313"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="549"/>
            <end position="561"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG01571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="660" mass="72178" checksum="3D86A57E2E00B741" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C3H6</accession>
    <name>A0A177C3H6_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Translationally-controlled tumor protein homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_1167574</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the TCTP family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441557">
        <property type="protein sequence ID" value="OAG01338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031703.1">
        <property type="nucleotide sequence ID" value="XM_018179206.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C3H6"/>
    <dbReference type="FunCoup" id="A0A177C3H6">
        <property type="interactions" value="861"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177C3H6"/>
    <dbReference type="GeneID" id="28762692"/>
    <dbReference type="InParanoid" id="A0A177C3H6"/>
    <dbReference type="OrthoDB" id="10248936at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.150.10:FF:000002">
        <property type="entry name" value="Translationally-controlled tumor protein homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.10">
        <property type="entry name" value="Metal Binding Protein, Guanine Nucleotide Exchange Factor, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011323">
        <property type="entry name" value="Mss4/transl-control_tumour"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034737">
        <property type="entry name" value="TCTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018103">
        <property type="entry name" value="Translation_control_tumour_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018105">
        <property type="entry name" value="Translational_control_tumour_p"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11991">
        <property type="entry name" value="TRANSLATIONALLY CONTROLLED TUMOR PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11991:SF0">
        <property type="entry name" value="TRANSLATIONALLY-CONTROLLED TUMOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00838">
        <property type="entry name" value="TCTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01653">
        <property type="entry name" value="TCTPROTEIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01002">
        <property type="entry name" value="TCTP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51797">
        <property type="entry name" value="TCTP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TCTP" evidence="3">
        <location>
            <begin position="1"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00014759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAG01338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="169" mass="18600" checksum="B2B12F75C3BCDEBB" modified="2016-09-07" version="1">MIIFKDSLTGDEIISDSYNLKEVDGIAYEADCSKITVGVDNIDIGANASAEGGDEDADDQAQTVIDVVHSFRLNETSFDKKQYLTHLKGYMKAVKAKLQEKGASADEVAAFEKGAQGFAKKIVANFKDYEFLIGESMDPDGMVILLNYREDGVTPYVTVWKHGLDEMKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C434</accession>
    <name>A0A177C434_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">glutathione transferase</fullName>
            <ecNumber evidence="2">2.5.1.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CC84DRAFT_1100355</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>RX + glutathione = an S-substituted glutathione + a halide anion + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16042"/>
            <dbReference type="ChEBI" id="CHEBI:17792"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="EC" id="2.5.1.18"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GST superfamily.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.18" evidence="2"/>
    <dbReference type="EMBL" id="KV441557">
        <property type="protein sequence ID" value="OAG01558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031923.1">
        <property type="nucleotide sequence ID" value="XM_018174863.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C434"/>
    <dbReference type="FunCoup" id="A0A177C434">
        <property type="interactions" value="110"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177C434"/>
    <dbReference type="GeneID" id="28758349"/>
    <dbReference type="InParanoid" id="A0A177C434"/>
    <dbReference type="OrthoDB" id="2098326at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004602">
        <property type="term" value="F:glutathione peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd03189">
        <property type="entry name" value="GST_C_GTT1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03046">
        <property type="entry name" value="GST_N_GTT1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000156">
        <property type="entry name" value="Glutathione S-transferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051:SF9">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14497">
        <property type="entry name" value="GST_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13409">
        <property type="entry name" value="GST_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST N-terminal" evidence="5">
        <location>
            <begin position="10"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="6">
        <location>
            <begin position="113"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAG01558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="262" mass="29620" checksum="BA998AAD00D4F49C" modified="2016-09-07" version="1">MSTVAKAGQGVKLTVHWLNESRGQRIVWLLEELNLDYDIKVYFRQKDKHSPPELKQVHPLGKSPLISIVAPGLEKPLVLAESAAIVEYVSDHFGQQLIPKRYPNGNDGLIGAETKEWLRFRFLMHYAEGSLMPVLLTGLLTHNIREAPVPFFLKFITKKIADMIDNNFTLAELKLNLSYLEALLAESPDDEFLCGANLTGADFMMIFVLEAAVLFKALNETSYPKLYSYVRRIQSRDAYKRAGDKVSEASGVKYVPFSEKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C4A3</accession>
    <name>A0A177C4A3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Acetyl-CoA synthetase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CC84DRAFT_1251993</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441556">
        <property type="protein sequence ID" value="OAG01991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032356.1">
        <property type="nucleotide sequence ID" value="XM_018184352.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C4A3"/>
    <dbReference type="STRING" id="1460663.A0A177C4A3"/>
    <dbReference type="GeneID" id="28767838"/>
    <dbReference type="InParanoid" id="A0A177C4A3"/>
    <dbReference type="OrthoDB" id="429813at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051414">
        <property type="entry name" value="Adenylate-forming_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43439:SF2">
        <property type="entry name" value="ENZYME, PUTATIVE (JCVI)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43439">
        <property type="entry name" value="PHENYLACETATE-COENZYME A LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23562">
        <property type="entry name" value="AMP-binding_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="576"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="663"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="539"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="663"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAG01991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="1136" mass="127595" checksum="FCC4A3C6DEEC9805" modified="2016-09-07" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C4I2</accession>
    <name>A0A177C4I2_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Autophagy-related protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CC84DRAFT_1179682</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Preautophagosomal structure membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="KV441557">
        <property type="protein sequence ID" value="OAG01637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032002.1">
        <property type="nucleotide sequence ID" value="XM_018180430.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C4I2"/>
    <dbReference type="STRING" id="1460663.A0A177C4I2"/>
    <dbReference type="GeneID" id="28763916"/>
    <dbReference type="InParanoid" id="A0A177C4I2"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005776">
        <property type="term" value="C:autophagosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010506">
        <property type="term" value="P:regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13993">
        <property type="entry name" value="STKc_Pat1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000693">
        <property type="entry name" value="Serine/threonine protein kinase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045269">
        <property type="entry name" value="Atg1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24348:SF22">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24348">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE UNC-51-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0072">Autophagy</keyword>
    <keyword evidence="6 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="18"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="466"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="550"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="471"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="495"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="572"/>
            <end position="581"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OAG01637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="651" mass="72205" checksum="83928A0065F3DFF2" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C5G3</accession>
    <name>A0A177C5G3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Glycoside hydrolase family 5 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CC84DRAFT_1098801</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 30 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441556">
        <property type="protein sequence ID" value="OAG02129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032494.1">
        <property type="nucleotide sequence ID" value="XM_018174785.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C5G3"/>
    <dbReference type="STRING" id="1460663.A0A177C5G3"/>
    <dbReference type="GeneID" id="28758271"/>
    <dbReference type="InParanoid" id="A0A177C5G3"/>
    <dbReference type="OrthoDB" id="2012278at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004348">
        <property type="term" value="F:glucosylceramidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006680">
        <property type="term" value="P:glucosylceramide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039514">
        <property type="entry name" value="6GAL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033452">
        <property type="entry name" value="GH30_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001139">
        <property type="entry name" value="Glyco_hydro_30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11069">
        <property type="entry name" value="GLUCOSYLCERAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11069:SF23">
        <property type="entry name" value="LYSOSOMAL ACID GLUCOSYLCERAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14587">
        <property type="entry name" value="Glyco_hydr_30_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17189">
        <property type="entry name" value="Glyco_hydro_30C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008057742" evidence="4">
        <location>
            <begin position="20"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="domain" description="Endo-beta-1,6-galactanase-like" evidence="5">
        <location>
            <begin position="22"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 30 beta sandwich" evidence="6">
        <location>
            <begin position="371"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF14587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF17189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAG02129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="460" mass="48896" checksum="68143C19A888F484" modified="2016-09-07" version="1">MHLLAPLVLIGHLTGLCAAQTAIKVDVTTKYQTIDGFGFSQAFGRATEFQNAASTLRTQALDYLFSTTKGAGFSIIRNRIGSGGSGDSILPNQPSSPSASPAYTWDKNDRGQLWFTKQAVSYGVKTIYADAWSAPGFMKTSGNEATPGYLCGTPGHSCSSGDWRQAYANFLVQYVKYYAQEGITITHLGFLNEPDYMVSYSQMQISDDAKEAIDFAPILYKTVQAAGLKTKITCCDAVGWTKQSTYTTALVNAGMTSTNIEVITGHSYSADATSPISQTTRPKWNTEGGPSGAFTTTWYSSGAANEGFSWAKRVATAMVNAQLSAYLFWEGFEFKQTQSALHLVDTLDGTNAALSGPFWSMAMWSRYIRPGAVRVGTSGSISNVIIGAFQNTDSSVVVVFTNSGTGSASASISFNGFTPKTAAAWQTSQGNNFVTTGATLANGAVAVTVPAHGVVTVKLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C5J3</accession>
    <name>A0A177C5J3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11 12">Endo-1,4-beta-xylanase</fullName>
            <ecNumber evidence="4 11 12">3.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CC84DRAFT_1253211</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11 12">
            <text>Endohydrolysis of (1-&gt;4)-beta-D-xylosidic linkages in xylans.</text>
            <dbReference type="EC" id="3.2.1.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 11 12">Glycan degradation; xylan degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11 12">Belongs to the glycosyl hydrolase 11 (cellulase G) family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.8" evidence="4 11 12"/>
    <dbReference type="EMBL" id="KV441556">
        <property type="protein sequence ID" value="OAG02421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032786.1">
        <property type="nucleotide sequence ID" value="XM_018184385.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C5J3"/>
    <dbReference type="SMR" id="A0A177C5J3"/>
    <dbReference type="GeneID" id="28767871"/>
    <dbReference type="InParanoid" id="A0A177C5J3"/>
    <dbReference type="OrthoDB" id="2115822at2759"/>
    <dbReference type="UniPathway" id="UPA00114"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031176">
        <property type="term" value="F:endo-1,4-beta-xylanase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013319">
        <property type="entry name" value="GH11/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033123">
        <property type="entry name" value="GH11_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001137">
        <property type="entry name" value="Glyco_hydro_11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46828:SF4">
        <property type="entry name" value="ENDO-1,4-BETA-XYLANASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46828">
        <property type="entry name" value="ENDO-1,4-BETA-XYLANASE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00457">
        <property type="entry name" value="Glyco_hydro_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00911">
        <property type="entry name" value="GLHYDRLASE11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51761">
        <property type="entry name" value="GH11_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11 12" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9 11 12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 11 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 11 12" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0732">Signal</keyword>
    <keyword evidence="5 11 12" id="KW-0858">Xylan degradation</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008057750" description="Endo-1,4-beta-xylanase" evidence="13">
        <location>
            <begin position="20"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="GH11" evidence="14">
        <location>
            <begin position="36"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="11">
        <location>
            <position position="120"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="11">
        <location>
            <position position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OAG02421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="228" mass="24207" checksum="2735E93A6BF7B8C9" modified="2016-09-07" version="1">MVAFSTLALGLAAATGIFAAPAAEPAAEAAFDAPDFEFSSAKSLDRRQDYNQNYKTSGNVNFSPTNNGYSVQFSGAGDFVVGKGWKTGTTRNINFSGSTTASSGTVLVSVYGWTTNPLVEYYVQEYTSNGAGSAQGQKVGSVTCDGSVYDIWKHQQVNQPSIQGTSTFWQYISNRQTKRPGSGTVTTSCHFDAWKKLGLNLGTHNYQTLSTEGWGNAGGSSQYTVSGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C6V5</accession>
    <name>A0A177C6V5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1177498</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG03484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033849.1">
        <property type="nucleotide sequence ID" value="XM_018180287.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C6V5"/>
    <dbReference type="STRING" id="1460663.A0A177C6V5"/>
    <dbReference type="GeneID" id="28763773"/>
    <dbReference type="InParanoid" id="A0A177C6V5"/>
    <dbReference type="OrthoDB" id="408373at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047372">
        <property type="term" value="F:monoacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046464">
        <property type="term" value="P:acylglycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050266">
        <property type="entry name" value="AB_hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798">
        <property type="entry name" value="MONOACYLGLYCEROL LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798:SF5">
        <property type="entry name" value="MONOACYLGLYCEROL LIPASE ABHD6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine aminopeptidase S33" evidence="1">
        <location>
            <begin position="22"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG03484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="265" mass="28753" checksum="6A4CA4E0C85F09B3" modified="2016-09-07" version="1">MPFLQIGYKKIHYTDLKPESSDARETFVFIHGLGSSQDYYHAVASGLQAHNFRCITFDTTGAGRSPYTQIEQSIQSLSDDVIGILDALGVSKAIVVGHSMGGIVGAHLAAERNDRVVAAVLIGPVYPNPAVVPVFEKRIQTVEKEGMEPMANTIPNAAVGKQASPLAKGFIRELLLGQDPAGYCSNCRVIINAKPPAYEKIAIPILILAGEEDKSAPLEGCQKMFNEIGTGEKKLEVMKGIGHWHALEAFEQVGQHILSFYHDIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C710</accession>
    <name>A0A177C710_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Glutamate decarboxylase-like protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_1178267</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6 7">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the group II decarboxylase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG02652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033017.1">
        <property type="nucleotide sequence ID" value="XM_018180328.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C710"/>
    <dbReference type="STRING" id="1460663.A0A177C710"/>
    <dbReference type="GeneID" id="28763814"/>
    <dbReference type="InParanoid" id="A0A177C710"/>
    <dbReference type="OrthoDB" id="392571at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.170">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45677:SF8">
        <property type="entry name" value="CYSTEINE SULFINIC ACID DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45677">
        <property type="entry name" value="GLUTAMATE DECARBOXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="5 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 6 7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="6">
        <location>
            <position position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602129-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAG02652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="538" mass="58439" checksum="C96B29555DAD1133" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C7V8</accession>
    <name>A0A177C7V8_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 12">Complex III subunit 9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CC84DRAFT_1123185</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The complex plays an important role in the uptake of multiple carbon sources present in different host niches.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme composed of 3 respiratory subunits cytochrome b, cytochrome c1 and Rieske protein, 2 core protein subunits, and additional low-molecular weight protein subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Mitochondrion inner membrane</location>
            <topology evidence="1 12">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the UQCR10/QCR9 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG03733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034098.1">
        <property type="nucleotide sequence ID" value="XM_018175652.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C7V8"/>
    <dbReference type="FunCoup" id="A0A177C7V8">
        <property type="interactions" value="287"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177C7V8"/>
    <dbReference type="GeneID" id="28759138"/>
    <dbReference type="InParanoid" id="A0A177C7V8"/>
    <dbReference type="OrthoDB" id="44067at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045275">
        <property type="term" value="C:respiratory chain complex III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006122">
        <property type="term" value="P:mitochondrial electron transport, ubiquinol to cytochrome c"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.260:FF:000001">
        <property type="entry name" value="Cytochrome b-c1 complex subunit 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.260">
        <property type="entry name" value="Cytochrome b-c1 complex subunit 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008027">
        <property type="entry name" value="QCR9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036656">
        <property type="entry name" value="QCR9_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12980:SF0">
        <property type="entry name" value="CYTOCHROME B-C1 COMPLEX SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12980">
        <property type="entry name" value="UBIQUINOL-CYTOCHROME C REDUCTASE COMPLEX, SUBUNIT X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05365">
        <property type="entry name" value="UCR_UQCRX_QCR9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81514">
        <property type="entry name" value="Subunit X (non-heme 7 kDa protein) of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0249">Electron transport</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 12" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU368056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OAG03733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="68" mass="7817" checksum="1F996513DA25E05A" modified="2016-09-07" version="1">MAGLTSFVYNTVFRSNVTMLTTVFASAFAMQLAFDTGSDRIWDSINRGRQWKDVKVRYVQKAEDDDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C8F3</accession>
    <name>A0A177C8F3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acyl-CoA N-acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1095707</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG03411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033776.1">
        <property type="nucleotide sequence ID" value="XM_018174626.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C8F3"/>
    <dbReference type="GeneID" id="28758112"/>
    <dbReference type="InParanoid" id="A0A177C8F3"/>
    <dbReference type="OrthoDB" id="4072826at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051531">
        <property type="entry name" value="N-acetyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43792">
        <property type="entry name" value="GNAT FAMILY, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G00765)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43792:SF1">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="15"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG03411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="195" mass="21931" checksum="22FF85097BC9A1A8" modified="2016-09-07" version="1">MVVVDATITARTERLLIRPLTMEDAEDIVLMRSHPETMKHTPLLPSDDVEKSRAWIQGCFDRDNCWNFVVELLPSAPGASTTSPRVIGMIGAVRAPEVGYMLNHKYWGKGYATEALRGFIPLFFEHFAGGPQGRFEYAEAQTDPELVASQHVLEKVGFKLHELREKDFDNPILGLRDTLVYRLYRPGGEGRAASE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C8N1</accession>
    <name>A0A177C8N1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transcriptional co-activator</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CC84DRAFT_865848</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG03756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034121.1">
        <property type="nucleotide sequence ID" value="XM_018187704.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C8N1"/>
    <dbReference type="FunCoup" id="A0A177C8N1">
        <property type="interactions" value="1013"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177C8N1"/>
    <dbReference type="GeneID" id="28771190"/>
    <dbReference type="InParanoid" id="A0A177C8N1"/>
    <dbReference type="OrthoDB" id="10264870at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024738">
        <property type="entry name" value="Hfi1/Tada1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21277">
        <property type="entry name" value="TRANSCRIPTIONAL ADAPTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21277:SF5">
        <property type="entry name" value="TRANSCRIPTIONAL ADAPTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12767">
        <property type="entry name" value="SAGA-Tad1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="11"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAG03756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="451" mass="49433" checksum="B7B66F5D91AD335C" modified="2016-09-07" version="1">MAGTIRPNDMDMSTTPIMSSKTLPDLSIPLKSASKPSTPRAPRIDVEPLYTAVKSALGDADWTTYKTSLSAFLLGNLNQEELTARLDAIFARAEAEAAKTLGPRGALERAHNALVMGVYANVWRDAPEAGIASWVSSSDKVSGSVPKGTGDESEKRLKQEVMQISRRERKRLKTIHQGASGGFDFMPLDPVGGMMMEYHEARRVKLPEAGPAAQAGGYGKTNWDLEIRKRYTAPLFTETHEFPTASSISLRLLPICYESGLPQGHAPDCADLLNIACENYIKEALTNFFTLVNANGTGYVRTAEYKKRVEREEARVARGEMVRLAGGELPVEHEERRKRKLLCMEDLRLALEIGDSYLAHVPILAGAISHSRCLDTPGVEDIYLPPRGKAMANGFNGTKPNPHALNLDRDRTRDVGDPMDIDEESNWQGGSVKDIDDLDSALDAVLELGDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C8R9</accession>
    <name>A0A177C8R9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1166911</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG03168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033533.1">
        <property type="nucleotide sequence ID" value="XM_018179079.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C8R9"/>
    <dbReference type="GeneID" id="28762565"/>
    <dbReference type="InParanoid" id="A0A177C8R9"/>
    <dbReference type="OrthoDB" id="3786778at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008057884" evidence="2">
        <location>
            <begin position="20"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="194"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="219"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG03168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="242" mass="25160" checksum="AEF6051D3AEF0447" modified="2016-09-07" version="1">MRFNFGLVALSALFVASSAAPTAAVTDLSAVQDVTDLSVVKDVTTKLPAVEGELNRRTDNVVYEKLQYTLVEVKKHTAVINSTVSSVHGVVSTVEKTKIIASVKSEVVIIVQLLSTVVGEITVLLTDITSITGDLKDNIISVVVELLVEILLTLNNVITALKITIFELLGPIIFALLAVIVNLLAVLNVIIVDLLKIVFGLLGGVAGILVHVLAGLGAIIGGLLGVVGGVLGLVGDIVGCIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C8Z6</accession>
    <name>A0A177C8Z6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1166230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG04123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034488.1">
        <property type="nucleotide sequence ID" value="XM_018178902.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C8Z6"/>
    <dbReference type="GeneID" id="28762388"/>
    <dbReference type="InParanoid" id="A0A177C8Z6"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="22"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG04123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="53" mass="6109" checksum="D92EAA52DAE54A8F" modified="2016-09-07" version="1">MRDRFFIATMGLGTSRLHVRKWILMVIMRLGFFATALIITSAKELIPRARVMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CA05</accession>
    <name>A0A177CA05_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Aquaporin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CC84DRAFT_1092871</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>H2O(in) = H2O(out)</text>
            <dbReference type="Rhea" id="RHEA:29667"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the MIP/aquaporin (TC 1.A.8) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG04483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034848.1">
        <property type="nucleotide sequence ID" value="XM_018174487.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CA05"/>
    <dbReference type="FunCoup" id="A0A177CA05">
        <property type="interactions" value="243"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CA05"/>
    <dbReference type="GeneID" id="28757973"/>
    <dbReference type="InParanoid" id="A0A177CA05"/>
    <dbReference type="OrthoDB" id="3222at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015250">
        <property type="term" value="F:water channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1080.10:FF:000014">
        <property type="entry name" value="Aquaporin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="entry name" value="Glycerol uptake facilitator protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034294">
        <property type="entry name" value="Aquaporin_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000425">
        <property type="entry name" value="MIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19139:SF283">
        <property type="entry name" value="AQUAPORIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19139">
        <property type="entry name" value="AQUAPORIN TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00230">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00783">
        <property type="entry name" value="MINTRINSICP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81338">
        <property type="entry name" value="Aquaporin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="4 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008058000" evidence="12">
        <location>
            <begin position="29"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="44"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="95"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="137"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="162"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="208"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="239"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="324"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="328"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OAG04483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="377" mass="40755" checksum="C7060610E8C3CDAE" modified="2016-09-07" version="1">MFVASVGEWVGTTLFLFFAFAGTQVANAHSRTSDESTTTNATAGFSPIVMLYISVSFGFSLMVNVWIFFRISGGLFNPAVTLALWATGAVGATRAVCLFISQIIGSITASALVLAMFPTPLNVRTTLSEGTSLAQGVFIEALMTAELVFTILMLAKEKHKSTFIAPVGIGLALFVAELVGVYYTGGSLNPARSLGPCVVTNKYDTEHWIYWVGPGIGSLLAIGFYKFIKMLEYEMANPGQDGDDNNDPTKNPNHEVREKQRLTTAKVLQSLGYPHLADGQGQASLDTMKQAEEGGYYGCRTPSVLDMADEPERRMNPGLVLSTVASRSDMHSPVRSDMHSPGRSDMHGPVRNDLHNPGYAPSERTSSDRRTNAGVYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CA20</accession>
    <name>A0A177CA20_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Short-chain dehydrogenase/reductase 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Retinal short-chain dehydrogenase/reductase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CC84DRAFT_1165825</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the reduction of all-trans-retinal to all-trans-retinol in the presence of NADPH.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG03607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033972.1">
        <property type="nucleotide sequence ID" value="XM_018178803.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CA20"/>
    <dbReference type="FunCoup" id="A0A177CA20">
        <property type="interactions" value="535"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CA20"/>
    <dbReference type="GeneID" id="28762289"/>
    <dbReference type="InParanoid" id="A0A177CA20"/>
    <dbReference type="OrthoDB" id="10253736at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052650">
        <property type="term" value="F:all-trans-retinol dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05339">
        <property type="entry name" value="17beta-HSDXI-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000131">
        <property type="entry name" value="Short-chain dehydrogenase/reductase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24322">
        <property type="entry name" value="PKSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24322:SF736">
        <property type="entry name" value="RETINOL DEHYDROGENASE 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="351"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="352"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00059620"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00068717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00082544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OAG03607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="370" mass="40565" checksum="4A0543563F350084" modified="2016-09-07" version="1">MPIRSEWKLAREGWTLDTTTRLLKATAFNPLITLPLILAAKYTARGAQVASQNETLFRTLKSLVALGVLGSISGFLDDKVVNNWKGDEWDWKKEVVVVTGGSDGIGKSIVLLLAEKGIKVAVLDVQPLTYEAPPSVQFFQCDLGSKEAIEATAASVRSSLGDPTVLINNAGVARGKSILDSTEKDIRLTFNVNALSHYFLAHQFLPSMIQRNHGMVVTVASLAAYLSAPNMVDYASSKAAALTFHEGLAAELATQYKADKVRTIIMCQGYTRTALFEGFAGKSLYPETVAEEIVKAVLKGRSAHLVVPESSWGIVPRVRSWPLWMQYGFRKGLKNLMKSWKGRQVVQPSETQVEKEKKGVEESAVLVEEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CA57</accession>
    <name>A0A177CA57_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Subtilisin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_1218950</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S8 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG03658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034023.1">
        <property type="nucleotide sequence ID" value="XM_018183044.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CA57"/>
    <dbReference type="STRING" id="1460663.A0A177CA57"/>
    <dbReference type="GeneID" id="28766530"/>
    <dbReference type="InParanoid" id="A0A177CA57"/>
    <dbReference type="OrthoDB" id="3800010at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0720">Serine protease</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="113"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="209"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="388"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="994"/>
            <end position="1043"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1073"/>
            <end position="1111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="38"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="59"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="73"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="113"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="132"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="388"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="433"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="994"/>
            <end position="1008"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1015"/>
            <end position="1043"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="1075"/>
            <end position="1099"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1101"/>
            <end position="1111"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="2">
        <location>
            <position position="647"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="2">
        <location>
            <position position="702"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="2">
        <location>
            <position position="893"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAG03658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1138" mass="120060" checksum="0F043CA8CE37471F" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CA98</accession>
    <name>A0A177CA98_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_1246214</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG04296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034661.1">
        <property type="nucleotide sequence ID" value="XM_018184194.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CA98"/>
    <dbReference type="STRING" id="1460663.A0A177CA98"/>
    <dbReference type="GeneID" id="28767680"/>
    <dbReference type="InParanoid" id="A0A177CA98"/>
    <dbReference type="OrthoDB" id="5283415at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF55">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="41"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="78"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="4"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAG04296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="112" mass="12933" checksum="5189B0CCB5EC8591" modified="2016-09-07" version="1">MVPAALCSLLFTPFFYMYIKLGYFGWRHEDVPKDYEPSQGLYWFYIAQLFYNPILALVKCSILVFILHIGRTRKGLPWMVYTGLAITVLHAISVFFAVLFSCVPIAAIWTRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CAA8</accession>
    <name>A0A177CAA8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Alcohol dehydrogenase 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CC84DRAFT_1120632</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG04306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034671.1">
        <property type="nucleotide sequence ID" value="XM_018175584.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CAA8"/>
    <dbReference type="STRING" id="1460663.A0A177CAA8"/>
    <dbReference type="GeneID" id="28759070"/>
    <dbReference type="InParanoid" id="A0A177CAA8"/>
    <dbReference type="OrthoDB" id="1879366at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08297">
        <property type="entry name" value="CAD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000039">
        <property type="entry name" value="Alcohol dehydrogenase AdhP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940:SF1">
        <property type="entry name" value="ENOYL REDUCTASE (ER) DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="8">
        <location>
            <begin position="26"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAG04306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="367" mass="39063" checksum="424E359E93B6B52F" modified="2016-09-07" version="1" fragment="single">MADSKEQEQVFEIPKTCKAGVVVNEGPDFRVEVRDVPVPEIKPNEVLVKLNATGICHSDLHFMLNDWALPKMSDLGTQCAGHEGAGVIVKVGSQVKTLKPGMRAGLKPIQDTCGACELCRTGDECYCAGAVLTGLTINGSYQQYIVSPERYTTIIPDGVSDFIAGPIMCSASTVYTSIKESGLQPGDWAVFPGAGGGVGMQGLQLAKAMGLRPVAIDTGADKKKLCIENGAEHFIDFKETSNVAEEVVKICDGVGAHAVYVTAVQSYPSSISFLGGRVGGKVMCIGLPPAGAFHIDVDPGQMCFRKQSVQGTLVSSMGDVDKTLQFAQRGLLKPICTVYPLSQFNEVVQKLRRGEIAGRAVIDFNTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CAE6</accession>
    <name>A0A177CAE6_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_865701</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG03748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034113.1">
        <property type="nucleotide sequence ID" value="XM_018187702.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CAE6"/>
    <dbReference type="STRING" id="1460663.A0A177CAE6"/>
    <dbReference type="GeneID" id="28771188"/>
    <dbReference type="InParanoid" id="A0A177CAE6"/>
    <dbReference type="OrthoDB" id="5244761at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053181">
        <property type="entry name" value="EcdB-like_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47785:SF4">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47785">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="250"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="335"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="407"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="500"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="671"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="35"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="47"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="68"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="185"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="199"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="212"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="416"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="695"/>
            <end position="705"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAG03748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="1134" mass="125426" checksum="559488E418DEB817" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CAX7</accession>
    <name>A0A177CAX7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CC84DRAFT_1147535</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG04725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035090.1">
        <property type="nucleotide sequence ID" value="XM_018176597.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CAX7"/>
    <dbReference type="STRING" id="1460663.A0A177CAX7"/>
    <dbReference type="GeneID" id="28760083"/>
    <dbReference type="InParanoid" id="A0A177CAX7"/>
    <dbReference type="OrthoDB" id="5417844at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF47">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="54"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="98"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="137"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="183"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="217"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="257"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="36"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="293"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="337"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="304"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAG04725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="392" mass="42697" checksum="62C89EDAE6E1EFF3" modified="2016-09-07" version="1">MASTAPKDETYEAFRSRFDGAIITTYVVAMLVVPLKIWCRKRAGGWSIMGADEIFTLCGAAFVTGTFAVIYSAVRPLLGKKIADVMQSPEDMAKLPAFALYLWVANLLYTISVMFMKLSIVALYWRLFGLTRKGRIPLLLVGGVIVAWGITVFLIVIFNCDPIAGSWDLTLATTAKCVDKKSFYVGGSVPNVITDLVLVIMPLPYVWRLHASVAQRIVLGGIFALGMFVSIVSMIRLSVLLDTAGGVFDVTYTFKDVYMWSLVEINVGLTCACLPSLRPLVKVIGLRRLFSSGRSRPSGAATPEPSQGLSGNVSGLNSRRKPKGMFSQLEDDDEFEMIPEDKMKGGAWSGGSTSRVSHDTDRTSNGSTDSRKQAAIGAIVVQRDFEVSSSRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CBB7</accession>
    <name>A0A177CBB7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">VWFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1166198</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG04077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034442.1">
        <property type="nucleotide sequence ID" value="XM_018178892.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CBB7"/>
    <dbReference type="STRING" id="1460663.A0A177CBB7"/>
    <dbReference type="GeneID" id="28762378"/>
    <dbReference type="InParanoid" id="A0A177CBB7"/>
    <dbReference type="OrthoDB" id="2142040at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34706">
        <property type="entry name" value="SLR1338 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34706:SF1">
        <property type="entry name" value="VWFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="2">
        <location>
            <begin position="106"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="37"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG04077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="312" mass="34112" checksum="AD037D0CCF01486F" modified="2016-09-07" version="1">MSMFGSLKKKLSRRGSNPLSQKSAEANTSTTQGGYLAPSNSSSFTNPSPATRRPSSSSTNPFARPGANDPPPAYTPGPTAPALVSRQPSIGPATDDDPYAFLRNFDTVFLIDDSGSMAGSRWGQVEQALSVIAPICAERDEDGIDVYFLNNKKIWKHQRTAGHIIEIFQDAKPGGQTFTGKRLYEMLTPYLARYKKYPANTKPVNIIVVTDGQAHDDVAGTIQDVAKKLDRWEAPPWQVGIQFFQIGNDPEARNMLKQLDDELAGSDDLRDIVDTVPFTSEAGAQLSATGIMKVVLGSVNRRLDRNSKELHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CBJ5</accession>
    <name>A0A177CBJ5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_886284</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG04070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034435.1">
        <property type="nucleotide sequence ID" value="XM_018187791.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CBJ5"/>
    <dbReference type="GeneID" id="28771277"/>
    <dbReference type="InParanoid" id="A0A177CBJ5"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="280"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG04070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="330" mass="36269" checksum="4C715B8B222E4487" modified="2016-09-07" version="1">MPGSLARKERRRKEREGMRSPAAAKTAYVESVDDEGEPRGGAVQKTEDKPADSNEGELPVPQTTLSPQERIANLTSDIPSLVPASEPPKGSQPRPQGPARPPPTSPATKNQDRDQIDQKQSKNRSKRGRPPRIPPESEPPFESLRNAPSSVYEEAIATLRNMSTEESARLRNVVISQMAAEGFPIVTEGLRSKRIQDPSYPVRSIINPPWAPSARKKDVMTEEEAENLRRAMFAKMSQSTDQDWVASMAQSLEKLKIEKSLALQASIGNVDGPSQSVEIVTPEQEAPSGEQAPIVQPKKREDTETVKSLLVTNIESKLKSLPHAGKYCTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CC91</accession>
    <name>A0A177CC91_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 9">Lysophospholipase</fullName>
            <ecNumber evidence="2 9">3.1.1.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CC84DRAFT_1147008</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a 1-acyl-sn-glycero-3-phosphocholine + H2O = sn-glycerol 3-phosphocholine + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15177"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16870"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:58168"/>
            <dbReference type="EC" id="3.1.1.5"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the lysophospholipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.5" evidence="2 9"/>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG04419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034784.1">
        <property type="nucleotide sequence ID" value="XM_018176574.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CC91"/>
    <dbReference type="STRING" id="1460663.A0A177CC91"/>
    <dbReference type="GeneID" id="28760060"/>
    <dbReference type="InParanoid" id="A0A177CC91"/>
    <dbReference type="OrthoDB" id="4084751at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004622">
        <property type="term" value="F:phosphatidylcholine lysophospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004623">
        <property type="term" value="F:phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046475">
        <property type="term" value="P:glycerophospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002642">
        <property type="entry name" value="LysoPLipase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10728">
        <property type="entry name" value="CYTOSOLIC PHOSPHOLIPASE A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10728:SF33">
        <property type="entry name" value="LYSOPHOSPHOLIPASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01735">
        <property type="entry name" value="PLA2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00022">
        <property type="entry name" value="PLAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51210">
        <property type="entry name" value="PLA2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 8 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 8 9" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="6 8 9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007948943" description="Lysophospholipase" evidence="9">
        <location>
            <begin position="20"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="domain" description="PLA2c" evidence="10">
        <location>
            <begin position="34"/>
            <end position="555"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OAG04419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="555" mass="58997" checksum="0E098B375B672590" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CCD6</accession>
    <name>A0A177CCD6_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RelA/SpoT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1176683</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG04469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034834.1">
        <property type="nucleotide sequence ID" value="XM_018180237.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CCD6"/>
    <dbReference type="STRING" id="1460663.A0A177CCD6"/>
    <dbReference type="GeneID" id="28763723"/>
    <dbReference type="InParanoid" id="A0A177CCD6"/>
    <dbReference type="OrthoDB" id="4719016at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015969">
        <property type="term" value="P:guanosine tetraphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05399">
        <property type="entry name" value="NT_Rel-Spo_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007685">
        <property type="entry name" value="RelA_SpoT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41773">
        <property type="entry name" value="GTP PYROPHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41773:SF1">
        <property type="entry name" value="RELA_SPOT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04607">
        <property type="entry name" value="RelA_SpoT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00954">
        <property type="entry name" value="RelA_SpoT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RelA/SpoT" evidence="2">
        <location>
            <begin position="61"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG04469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="522" mass="60162" checksum="AD547D6BD0C4D482" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CCN2</accession>
    <name>A0A177CCN2_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Carboxypeptidase</fullName>
            <ecNumber evidence="14">3.4.16.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CC84DRAFT_1144759</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Extracellular serine carboxypeptidase that contributes to pathogenicity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Preferential release of a C-terminal arginine or lysine residue.</text>
            <dbReference type="EC" id="3.4.16.6"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the peptidase S10 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.-" evidence="14"/>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG05414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035779.1">
        <property type="nucleotide sequence ID" value="XM_018176468.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CCN2"/>
    <dbReference type="STRING" id="1460663.A0A177CCN2"/>
    <dbReference type="GeneID" id="28759954"/>
    <dbReference type="InParanoid" id="A0A177CCN2"/>
    <dbReference type="OrthoDB" id="443318at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018202">
        <property type="entry name" value="Ser_caboxypep_ser_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF189">
        <property type="entry name" value="CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00131">
        <property type="entry name" value="CARBOXYPEPT_SER_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 14" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="9 14 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 14" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 14" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0843">Virulence</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007948945" description="Carboxypeptidase" evidence="14">
        <location>
            <begin position="21"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="623"/>
            <end position="648"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00037356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU361156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OAG05414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="680" mass="74525" checksum="6D2EB1A9B6DD7145" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CCT8</accession>
    <name>A0A177CCT8_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ecp2 effector protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1165463</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG05136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035501.1">
        <property type="nucleotide sequence ID" value="XM_018178718.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CCT8"/>
    <dbReference type="STRING" id="1460663.A0A177CCT8"/>
    <dbReference type="GeneID" id="28762204"/>
    <dbReference type="InParanoid" id="A0A177CCT8"/>
    <dbReference type="OrthoDB" id="5006988at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008057998" description="Ecp2 effector protein domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG05136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="179" mass="18282" checksum="A4D96F5985DD84C9" modified="2016-09-07" version="1">MRFTATFALPLLLSSVTAFVIPQGQADGAYSVQLDSRGNEIHARLSDAPEISVREASPLVARAVQSYCGCGIGLNAGDTDAANADLVSQLGRGSNIGAHLAYYSKRGGVVAFACNLSGGTKLFAGDAIGQNNAQITASCGRYIAGSRGEPGNWATGYMRTSENGGNFCGAALSSGAHNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CEA8</accession>
    <name>A0A177CEA8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1164377</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG05964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036329.1">
        <property type="nucleotide sequence ID" value="XM_018178475.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CEA8"/>
    <dbReference type="STRING" id="1460663.A0A177CEA8"/>
    <dbReference type="GeneID" id="28761961"/>
    <dbReference type="InParanoid" id="A0A177CEA8"/>
    <dbReference type="OrthoDB" id="5333304at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="55"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="182"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="697"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="133"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="68"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="199"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="218"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="256"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="339"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="400"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="425"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="700"/>
            <end position="724"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG05964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="730" mass="82927" checksum="89DA742BF3AECF46" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CEL8</accession>
    <name>A0A177CEL8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1091617</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG06083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036448.1">
        <property type="nucleotide sequence ID" value="XM_018174407.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CEL8"/>
    <dbReference type="GeneID" id="28757893"/>
    <dbReference type="InParanoid" id="A0A177CEL8"/>
    <dbReference type="OrthoDB" id="3438274at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG06083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="232" mass="25939" checksum="9D28A5E1021A737F" modified="2016-09-07" version="1">MDEADVASAPKHDATLDGLKRACEIKNQITGKTLHILAPKPMRVSTCAVEMDPDNQAIKEMRQEHSMTWEAIVVELNKKRLERGEPQTWTPAAVYSRFVRSAPRIVAAKGEYGFRAQDYMHLRNPQDHPAAQLPGAINNPSGYQFGAGGGRKRVRDEDHAAKDLADNLRQPVSETLSEQMEILKKADMSELMMEAVATAEQEFWGTVANALEKKTGKLFVAKVLESRFHEIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CEY4</accession>
    <name>A0A177CEY4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Lysosomal dipeptide transporter MFSD1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Major facilitator superfamily domain-containing protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">CC84DRAFT_753994</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Lysosomal dipeptide uniporter that selectively exports lysine, arginine or histidine-containing dipeptides with a net positive charge from the lysosome lumen into the cytosol. Could play a role in a specific type of protein O-glycosylation indirectly regulating macrophages migration and tissue invasion. Also essential for liver homeostasis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-alanyl-L-lysine(out) = L-alanyl-L-lysine(in)</text>
            <dbReference type="Rhea" id="RHEA:79415"/>
            <dbReference type="ChEBI" id="CHEBI:192470"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>L-alpha-aminoacyl-L-arginine(out) = L-alpha-aminoacyl-L-arginine(in)</text>
            <dbReference type="Rhea" id="RHEA:79367"/>
            <dbReference type="ChEBI" id="CHEBI:229968"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-alpha-aminoacyl-L-histidine(out) = L-alpha-aminoacyl-L-histidine(in)</text>
            <dbReference type="Rhea" id="RHEA:79375"/>
            <dbReference type="ChEBI" id="CHEBI:229967"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-alpha-aminoacyl-L-lysine(out) = L-alpha-aminoacyl-L-lysine(in)</text>
            <dbReference type="Rhea" id="RHEA:79383"/>
            <dbReference type="ChEBI" id="CHEBI:229966"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-arginyl-L-alpha-amino acid(out) = L-arginyl-L-alpha-amino acid(in)</text>
            <dbReference type="Rhea" id="RHEA:79371"/>
            <dbReference type="ChEBI" id="CHEBI:84315"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-arginyl-glycine(out) = L-arginyl-glycine(in)</text>
            <dbReference type="Rhea" id="RHEA:79391"/>
            <dbReference type="ChEBI" id="CHEBI:229955"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-aspartyl-L-lysine(out) = L-aspartyl-L-lysine(in)</text>
            <dbReference type="Rhea" id="RHEA:79411"/>
            <dbReference type="ChEBI" id="CHEBI:229953"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-histidyl-L-alpha-amino acid(out) = L-histidyl-L-alpha-amino acid(in)</text>
            <dbReference type="Rhea" id="RHEA:79379"/>
            <dbReference type="ChEBI" id="CHEBI:229964"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>L-histidyl-glycine(out) = L-histidyl-glycine(in)</text>
            <dbReference type="Rhea" id="RHEA:79395"/>
            <dbReference type="ChEBI" id="CHEBI:229957"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>L-lysyl-L-alanine(out) = L-lysyl-L-alanine(in)</text>
            <dbReference type="Rhea" id="RHEA:79399"/>
            <dbReference type="ChEBI" id="CHEBI:229954"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-lysyl-L-alpha-amino acid(out) = L-lysyl-L-alpha-amino acid(in)</text>
            <dbReference type="Rhea" id="RHEA:79387"/>
            <dbReference type="ChEBI" id="CHEBI:229965"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-lysyl-L-lysine(out) = L-lysyl-L-lysine(in)</text>
            <dbReference type="Rhea" id="RHEA:79403"/>
            <dbReference type="ChEBI" id="CHEBI:229956"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-lysyl-glycine(out) = L-lysyl-glycine(in)</text>
            <dbReference type="Rhea" id="RHEA:79407"/>
            <dbReference type="ChEBI" id="CHEBI:191202"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="18">Homodimer. Interacts with lysosomal protein GLMP (via lumenal domain); the interaction starts while both proteins are still in the endoplasmic reticulum and is required for stabilization of MFSD1 in lysosomes but has no direct effect on its targeting to lysosomes or transporter activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG06184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036549.1">
        <property type="nucleotide sequence ID" value="XM_018187307.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CEY4"/>
    <dbReference type="STRING" id="1460663.A0A177CEY4"/>
    <dbReference type="GeneID" id="28770793"/>
    <dbReference type="InParanoid" id="A0A177CEY4"/>
    <dbReference type="OrthoDB" id="424834at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052187">
        <property type="entry name" value="MFSD1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23512">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23512:SF12">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G00260)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="19" id="KW-0472">Membrane</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="90"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="186"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="245"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="285"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="311"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="339"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="408"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="471"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="20">
        <location>
            <begin position="27"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00044876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00044878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00044881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00044884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00044912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00044924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00044985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00045018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00045709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00046376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="OAG06184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="497" mass="54193" checksum="8FFDB64F317F2367" modified="2016-09-07" version="1">MATIPESDASSNTGTLTPAPLQWKIMAILLITAIGFGSNWSSGITGAMKSTIKKEMKVNNTQFALLEASEDFMVTALMLVSGLVTDRIGGAGAMLYGNAIYSIGSILVAGAAQTRSYKFMIAGRVLRALGDIATQVAQYKVFSSWFAPGNGFASTLGFELGVGKIGAFAGKASANIIAKRTGDFAWVFWVAVFMNLFTNVMTGVFYWFTKVANRKFHGVTDPATGEVLKEKSKKFELKKALNMPWTFWCIMAFSLFETSTALVFLQNATELAEQRFETDSILAGWYSATAQYAGFFFVPLIGVFLDVFGHRISALVFCGIGVFTSMLLVCFAKTTKGTAASFGLFAFANCFGPTTIIDSIRTSMWHPSVFGSAYALKITMNNAMNIIVRVITGVIQDRDNNSYDRVTIVYVVLAGVSVAVSLGLSVASWKFVDLRQLQWSRKLRIARGDVLHERRRRFEAGEGKSRPISKACLVALVVFVLGGWSAYFWGVATGRNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CF28</accession>
    <name>A0A177CF28_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Hemerythrin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1091120</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG05357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035722.1">
        <property type="nucleotide sequence ID" value="XM_018174389.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CF28"/>
    <dbReference type="GeneID" id="28757875"/>
    <dbReference type="InParanoid" id="A0A177CF28"/>
    <dbReference type="OrthoDB" id="58416at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12108">
        <property type="entry name" value="Hr-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.520">
        <property type="entry name" value="nmb1532 protein domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053206">
        <property type="entry name" value="Dimeric_xanthone_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012312">
        <property type="entry name" value="Hemerythrin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38048">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38048:SF2">
        <property type="entry name" value="HEMERYTHRIN-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01814">
        <property type="entry name" value="Hemerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hemerythrin-like" evidence="2">
        <location>
            <begin position="40"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG05357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="259" mass="28505" checksum="9BB1342A1A17CBC7" modified="2016-09-07" version="1">MAPSTPAWADGPLPLIQTPSATKDTNDHPAHYIANEMAWAHNAMLRGLNAIYLQAPHVQQGDAADFLFFIASWSAWVLHHHTIEEKQMFPGFEAVPGVAPGSLSHNVEQHHEFSEGLSGLQKYATATTADSYSGAHVQKLVDGFSPILRQHLADEIDTLWAMDSVAANTEHSKKLLNIYQQCEAEAGKQDKSVVPPMVLGLCDKTFEGGNDWPKMPMGSAYFVHYLFARKHSKAWRFLPCDTFGKPRPLAFLGNNGAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CF62</accession>
    <name>A0A177CF62_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1164562</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG06253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036618.1">
        <property type="nucleotide sequence ID" value="XM_018178509.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CF62"/>
    <dbReference type="GeneID" id="28761995"/>
    <dbReference type="InParanoid" id="A0A177CF62"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG06253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="58" mass="6615" checksum="FA3B3B74632EB427" modified="2016-09-07" version="1">MCLKVQPSYIVSGEHVHVRASLLHVSTRRHNTCSLTHPDTNLTTTHQHHPPLRSLQKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CF92</accession>
    <name>A0A177CF92_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Jacalin-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_1175650</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG05488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035853.1">
        <property type="nucleotide sequence ID" value="XM_018180167.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CF92"/>
    <dbReference type="GeneID" id="28763653"/>
    <dbReference type="InParanoid" id="A0A177CF92"/>
    <dbReference type="OrthoDB" id="3784429at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd20231">
        <property type="entry name" value="PFM_jacalin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.100.10.30">
        <property type="entry name" value="Jacalin-like lectin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.15.10">
        <property type="entry name" value="Proaerolysin, chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001229">
        <property type="entry name" value="Jacalin-like_lectin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036404">
        <property type="entry name" value="Jacalin-like_lectin_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01419">
        <property type="entry name" value="Jacalin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56973">
        <property type="entry name" value="Aerolisin/ETX pore-forming domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51101">
        <property type="entry name" value="Mannose-binding lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51752">
        <property type="entry name" value="JACALIN_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008058129" description="Jacalin-type lectin domain-containing protein" evidence="2">
        <location>
            <begin position="25"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="domain" description="Jacalin-type lectin" evidence="3">
        <location>
            <begin position="33"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="375"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="375"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="403"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="440"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="614"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="634"/>
            <end position="650"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAG05488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="690" mass="75307" checksum="8F0ED2C0F1798C60" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CFJ1</accession>
    <name>A0A177CFJ1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1259019</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG05609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035974.1">
        <property type="nucleotide sequence ID" value="XM_018184873.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CFJ1"/>
    <dbReference type="STRING" id="1460663.A0A177CFJ1"/>
    <dbReference type="GeneID" id="28768359"/>
    <dbReference type="InParanoid" id="A0A177CFJ1"/>
    <dbReference type="OrthoDB" id="74545at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37015">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37015:SF1">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG05609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="881" mass="101687" checksum="4F040AB570192EBC" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CFR0</accession>
    <name>A0A177CFR0_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Translocation protein SEC62</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CC84DRAFT_1146052</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SEC62 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG06166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036531.1">
        <property type="nucleotide sequence ID" value="XM_018176542.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CFR0"/>
    <dbReference type="FunCoup" id="A0A177CFR0">
        <property type="interactions" value="120"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CFR0"/>
    <dbReference type="GeneID" id="28760028"/>
    <dbReference type="InParanoid" id="A0A177CFR0"/>
    <dbReference type="OrthoDB" id="200187at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031204">
        <property type="term" value="P:post-translational protein targeting to membrane, translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004728">
        <property type="entry name" value="Sec62"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011553">
        <property type="entry name" value="Sec62_asco"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00869">
        <property type="entry name" value="sec62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12443">
        <property type="entry name" value="TRANSLOCATION PROTEIN SEC62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12443:SF9">
        <property type="entry name" value="TRANSLOCATION PROTEIN SEC62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03839">
        <property type="entry name" value="Sec62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0811">Translocation</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="232"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="256"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="72"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="339"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="72"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="339"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="360"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OAG06166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="414" mass="45901" checksum="690AFA7E131298EC" modified="2016-09-07" version="1">MSSEAPPQPEGPPQGPPQGPPQGMPMGPPQPGQQPTPEQIAHMQRQLAIEAEKAGMTVPEYINRLKQQAMAQHQAQLRQQQMQQQQQQQQQQPIQPGPPQPDAIALANWLKNQDLKPRTVIHDEKRKDMFRVKRAIRALMSPAYEKACSKNPILPKVNDRVTAENAFKKLPLSLLALRVNKVDPDHAHDGHNHAKAKRVKGLWTVRIEQHQEANDDCYYIWLYEGSQWKQKLYAVGALVGILAVVLFPLWPMKLRLGVWYLSMGMLGLIGLFFAMAIFRLILFIITMFTAAPGLWLYPNLFEDVGFFDSFRPVWAWQETPEDIKNKKRAKKEKKAAKLAAKAAGTPLKPAKGKKAISGTATPQPEAQAEAAAPAPAPVAAESAPQPTGSEAAPPSGTVSQRPPRATVEEAEDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CFZ2</accession>
    <name>A0A177CFZ2_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF7726 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1164787</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG06534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036899.1">
        <property type="nucleotide sequence ID" value="XM_018178562.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CFZ2"/>
    <dbReference type="GeneID" id="28762048"/>
    <dbReference type="InParanoid" id="A0A177CFZ2"/>
    <dbReference type="OrthoDB" id="2592504at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056143">
        <property type="entry name" value="DUF7726"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42339">
        <property type="entry name" value="HISTONE H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42339:SF1">
        <property type="entry name" value="HISTONE H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24852">
        <property type="entry name" value="DUF7726"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7726" evidence="1">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7726" evidence="1">
        <location>
            <begin position="107"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG06534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="244" mass="27402" checksum="7EC69865E51356B0" modified="2016-09-07" version="1">MPMTESCDVVRRKIRTFLDSGEMKVGEFQDAINVTGNAYSRFMGQNGPYKGMGSSVYDAAWVFFKKREMKGIKMPKKTAASMGGASSSSVPSVESIVLDFEREEKVPIFDTCDDIRRKINAHLKLPGVTQASFLHNVGAQYHPARRVQSSQLSAFRSKKGPFAGNTSVMFYGAYVYFEKLRIKQNKPKGKKREEMERLHGPYGGIDHDRPRRSYLALAGSSVTEDQYGRVHISGPRESGVFPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CG60</accession>
    <name>A0A177CG60_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CC84DRAFT_1053897</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG06575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036940.1">
        <property type="nucleotide sequence ID" value="XM_018173515.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CG60"/>
    <dbReference type="STRING" id="1460663.A0A177CG60"/>
    <dbReference type="GeneID" id="28757001"/>
    <dbReference type="InParanoid" id="A0A177CG60"/>
    <dbReference type="OrthoDB" id="410267at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF90">
        <property type="entry name" value="CENTROMERE DNA-BINDING PROTEIN COMPLEX CBF3 SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="511"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="9"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="89"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="578"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAG06575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="578" mass="64701" checksum="A45A095D292172E1" modified="2016-09-07" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CG95</accession>
    <name>A0A177CG95_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">TPR-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CC84DRAFT_1164381</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Regulates mitochondrial small subunit maturation by controlling 15S rRNA 5'-end processing. Localizes to the 5' precursor of the 15S rRNA in a position that is subsequently occupied by mS47 in the mature yeast mtSSU. Uses structure and sequence-specific RNA recognition, binding to a single-stranded region of the precursor and specifically recognizing bases -6 to -1. The exchange of Ccm1 for mS47 is coupled to the irreversible removal of precursor rRNA that is accompanied by conformational changes of the mitoribosomal proteins uS5m and mS26. These conformational changes signal completion of 5'-end rRNA processing through protection of the mature 5'-end of the 15S rRNA and stabilization of mS47. The removal of the 5' precursor together with the dissociation of Ccm1 may be catalyzed by the 5'-3' exoribonuclease Pet127. Involved in the specific removal of group I introns in mitochondrial encoded transcripts.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Binds to mitochondrial small subunit 15S rRNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CCM1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG05972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036337.1">
        <property type="nucleotide sequence ID" value="XM_018178476.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CG95"/>
    <dbReference type="STRING" id="1460663.A0A177CG95"/>
    <dbReference type="GeneID" id="28761962"/>
    <dbReference type="InParanoid" id="A0A177CG95"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47936:SF1">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN GUN1, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47936">
        <property type="entry name" value="PPR_LONG DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01535">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13041">
        <property type="entry name" value="PPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="PPR" evidence="5">
        <location>
            <begin position="521"/>
            <end position="555"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00044493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00044511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAG05972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="1095" mass="125737" checksum="021E566AC29C48EC" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CGW6</accession>
    <name>A0A177CGW6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Heat shock protein Hsp88</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_1176157</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG06098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036463.1">
        <property type="nucleotide sequence ID" value="XM_018180198.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CGW6"/>
    <dbReference type="FunCoup" id="A0A177CGW6">
        <property type="interactions" value="1447"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CGW6"/>
    <dbReference type="GeneID" id="28763684"/>
    <dbReference type="InParanoid" id="A0A177CGW6"/>
    <dbReference type="OrthoDB" id="434160at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd24094">
        <property type="entry name" value="ASKHA_NBD_HSP70_ScSse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.10:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.30:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000171">
        <property type="entry name" value="Heat shock 70 kDa protein 4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000004">
        <property type="entry name" value="Heat shock 70 kDa protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.34.10:FF:000011">
        <property type="entry name" value="Heat shock protein hsp88"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45639:SF4">
        <property type="entry name" value="HSC70CB, ISOFORM G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45639">
        <property type="entry name" value="HSC70CB, ISOFORM G-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0346">Stress response</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="504"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="721"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="525"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="555"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="571"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="721"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="756"/>
            <end position="771"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAG06098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="778" mass="87064" checksum="5A96D8F5C2A0475D" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CH08</accession>
    <name>A0A177CH08_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">HSP90-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CC84DRAFT_622774</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the heat shock protein 90 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG06853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037218.1">
        <property type="nucleotide sequence ID" value="XM_018186926.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CH08"/>
    <dbReference type="FunCoup" id="A0A177CH08">
        <property type="interactions" value="1393"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CH08"/>
    <dbReference type="GeneID" id="28770412"/>
    <dbReference type="InParanoid" id="A0A177CH08"/>
    <dbReference type="OrthoDB" id="28737at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140453">
        <property type="term" value="C:protein aggregate center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd16927">
        <property type="entry name" value="HATPase_Hsp90-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.790:FF:000001">
        <property type="entry name" value="Heat shock protein 90 alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.80:FF:000001">
        <property type="entry name" value="Heat shock protein 90 alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11260:FF:000001">
        <property type="entry name" value="Heat shock protein 90 alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000001">
        <property type="entry name" value="Heat shock protein HSP 90-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.790">
        <property type="entry name" value="Heat shock protein 90, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00505">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019805">
        <property type="entry name" value="Heat_shock_protein_90_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037196">
        <property type="entry name" value="HSP90_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001404">
        <property type="entry name" value="Hsp90_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020575">
        <property type="entry name" value="Hsp90_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003555">
        <property type="entry name" value="PRK05218.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11528">
        <property type="entry name" value="HEAT SHOCK PROTEIN 90 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13589">
        <property type="entry name" value="HATPase_c_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00183">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002583">
        <property type="entry name" value="Hsp90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00775">
        <property type="entry name" value="HEATSHOCK90"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110942">
        <property type="entry name" value="HSP90 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00298">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Histidine kinase/HSP90-like ATPase" evidence="9">
        <location>
            <begin position="25"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="213"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="675"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="214"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="98"/>
            <end position="99"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="118"/>
            <end position="123"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="373"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR002583-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAG06853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="700" mass="79764" checksum="B75100DB2A7A2F9D" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CH99</accession>
    <name>A0A177CH99_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Eukaryotic translation initiation factor 2 subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CC84DRAFT_1090454</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S pre-initiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must exchange with GTP by way of a reaction catalyzed by eIF2B.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eIF-2-alpha family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG06160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036525.1">
        <property type="nucleotide sequence ID" value="XM_018174356.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CH99"/>
    <dbReference type="FunCoup" id="A0A177CH99">
        <property type="interactions" value="1281"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CH99"/>
    <dbReference type="GeneID" id="28757842"/>
    <dbReference type="InParanoid" id="A0A177CH99"/>
    <dbReference type="OrthoDB" id="1685042at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005850">
        <property type="term" value="C:eukaryotic translation initiation factor 2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043614">
        <property type="term" value="C:multi-eIF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990856">
        <property type="term" value="F:methionyl-initiator methionine tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001731">
        <property type="term" value="P:formation of translation preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd04452">
        <property type="entry name" value="S1_IF2_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1130:FF:000001">
        <property type="entry name" value="Eukaryotic translation initiation factor 2 subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000015">
        <property type="entry name" value="Eukaryotic translation initiation factor 2 subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.190:FF:000002">
        <property type="entry name" value="Translation initiation factor 2, alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1130">
        <property type="entry name" value="EIF_2_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.190">
        <property type="entry name" value="Translation initiation factor 2, subunit 1, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044126">
        <property type="entry name" value="S1_IF2_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024055">
        <property type="entry name" value="TIF2_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024054">
        <property type="entry name" value="TIF2_asu_middle_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011488">
        <property type="entry name" value="TIF_2_asu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10602">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10602:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07541">
        <property type="entry name" value="EIF_2_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110993">
        <property type="entry name" value="eIF-2-alpha, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116742">
        <property type="entry name" value="eIF2alpha middle domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="S1 motif" evidence="11">
        <location>
            <begin position="17"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="273"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00060206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OAG06160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="311" mass="35229" checksum="1E54B2294BE671A4" modified="2016-09-07" version="1">MSLTNSRFYEEKYPEVESFVMVNVKQIAEMGAYVKLLEYDNIDGMILLSELSRRRIRSIQKLIRVGRNEVVVVLRVDKDKGYIDLSKRRVSPEDIIKCEERYNKSKMVHSIMRHVAEKTETPIQELYENIGWPLNKKYGHSIDAFKLSITNPDVWKDVTFPNDVVKDELQTYISKRLTPQPTKVRSDIEVTCFGYEGIDAVKEALRTAEAKNTQDTQVKVKLVSPPLYVLTSQCLDKSIGIQVLEQAIEDIKASITKAGGDCSVKMAPKAVTENDDAELAALMEKRERENQEVSGDEDESTSDEGGVAEAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CHM1</accession>
    <name>A0A177CHM1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Malate dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1163311</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG07063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037428.1">
        <property type="nucleotide sequence ID" value="XM_018178233.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CHM1"/>
    <dbReference type="GeneID" id="28761719"/>
    <dbReference type="InParanoid" id="A0A177CHM1"/>
    <dbReference type="OrthoDB" id="1859733at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021851">
        <property type="entry name" value="DUF3455"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35567">
        <property type="entry name" value="MALATE DEHYDROGENASE (AFU_ORTHOLOGUE AFUA_2G13800)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35567:SF11">
        <property type="entry name" value="MALATE DEHYDROGENASE (AFU_ORTHOLOGUE AFUA_2G13800)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11937">
        <property type="entry name" value="DUF3455"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008058306" description="Malate dehydrogenase" evidence="1">
        <location>
            <begin position="18"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG07063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="220" mass="23126" checksum="E765E836757CB1A4" modified="2016-09-07" version="1">MFSTLIIAAVALPLALAAPAPYRLPESVFRRQLNDTCGLSTVQQPPSKLTPPGDHNQLVLIALGQGTQNYTCTNETAIPASIGAVANLFNASCAVSQKTSLGSVAEDANAVGQHFFVDNTTPEFDIIGLGNTQLKKAEADPAPNAATDVPWLKLDATNTNTAVRSIYRLNTKGGVAPATCAGQAAGAVVQVDYEAQYWVYACPDAMAARRQKRSLGLPLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CHN2</accession>
    <name>A0A177CHN2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1064023</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG06741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037106.1">
        <property type="nucleotide sequence ID" value="XM_018173621.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CHN2"/>
    <dbReference type="GeneID" id="28757107"/>
    <dbReference type="InParanoid" id="A0A177CHN2"/>
    <dbReference type="OrthoDB" id="10251048at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="218"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="229"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG06741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="479" mass="52740" checksum="D4AB8E7D3B36C03B" modified="2016-09-07" version="1" fragment="single">LGTPTAHLTSASQPHSHIRIVPREQLDSDSYEDSTPTFRSSSLQLPPLPLRDRGSRTGSAHSEVSTPINTTFAQMARRSNKNDMEGVEKPTSGPVPLSGFVSFKTHSDGSDNISPTDTRPPAIENHLRLFEQLPDIIRLQEQTGDFDGQVVFIGHPNRDVSAHQWISDSYQWINVGLWSHTRKRIEGSLASDRLATSELSFNSIEYFKFAAERRESMIKEHGRPRTDPEATNTEPTPTEANTDQTSEAPVGSFAATSARTVTGEKLEDPFITPGNILQPAPMLVFNFREGGPTVANPYRGISTLNAAAAPYRMLPKKQSSGESDSSVPAFNIPVSASDPALRFSDPDGRQEHVHPIANGFNKQAPTRQNWSGPFFADSMPTTHDPLASLSAQISIEEKLRNWYRDGQSVIRQQDYAKTLVAAASASNKNRSFAVIGDGSARKQDLSKHANTHLFARVYEHLSEYAEQSRTDGGQSCFTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CHP9</accession>
    <name>A0A177CHP9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CBM1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_763662</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG06398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036763.1">
        <property type="nucleotide sequence ID" value="XM_018187345.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CHP9"/>
    <dbReference type="GeneID" id="28770831"/>
    <dbReference type="InParanoid" id="A0A177CHP9"/>
    <dbReference type="OrthoDB" id="3799394at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008058312" description="CBM1 domain-containing protein" evidence="1">
        <location>
            <begin position="17"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG06398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="191" mass="20898" checksum="47A758CB744DFC2F" modified="2016-09-07" version="1">MRFFTLAASLISLTLAQHYHHPSITCSPSPTTPSIEPPRYTIPCTMSDDSPCPSGWFCTPTTIPPTATTDPWGGVCKDNPTPPPVTPCVMGNDTPCLPSSRCTPTTIPPANPTDPWGGQCIAGPPTSTSEWDTEYTQTFTPITPSVYTPYTSPVKSYDSPVPTWTGRPCRFEWQCRRGRGEKCVRGRCVLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CHR7</accession>
    <name>A0A177CHR7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyl hydrolase-like protein family 88</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1163162</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG06856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037221.1">
        <property type="nucleotide sequence ID" value="XM_018178192.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CHR7"/>
    <dbReference type="STRING" id="1460663.A0A177CHR7"/>
    <dbReference type="GeneID" id="28761678"/>
    <dbReference type="InParanoid" id="A0A177CHR7"/>
    <dbReference type="OrthoDB" id="2305845at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010905">
        <property type="entry name" value="Glyco_hydro_88"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052043">
        <property type="entry name" value="PolySaccharide_Degr_Enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33886">
        <property type="entry name" value="UNSATURATED RHAMNOGALACTURONAN HYDROLASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33886:SF8">
        <property type="entry name" value="UNSATURATED RHAMNOGALACTURONAN HYDROLASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07470">
        <property type="entry name" value="Glyco_hydro_88"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG06856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="452" mass="51432" checksum="5CDE6CDDEC3F6245" modified="2016-09-07" version="1">MVGTLWTDYSSAATITISLPKLWGFNNTILRSSNLAIRSTDTFGELEFCSHLSTKVLYRRESVDRGVQSAQDWPIMSTLTIHGLKSDDIHSAIQLLTHNLINIHDTTGEFLLKLDDGRVIDTKGWDGWEWTHGIGLYGLWHYYTLTGSQNTKDIMTGWFQKQLAKGTTKNINTMSPFLTLAYLYEDTGNRTYLPWLDTWAEWLMNGLPRTKYGGFQHETYNSFNKDELWDDTLMMSALPLAKIGLTLDRPEYVDEARRQFQLHCQYLFDTSTGLFFHGWKWEEGKDGSIGHNFARARWARGNSWLTIVLPEFVELLRLQPDDPLRQFLLGIFEAQCKALVKYQGENGMWRTLIDLPLENGNYEESSATAGFAYGMLKGVRKGYLGKEYLEPAVKAVKAVIGKIDDKGELQGTSFGTAMGPDLDFYCKIPITSMPYGQAMAIMALGEFLRTFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CI00</accession>
    <name>A0A177CI00_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CC84DRAFT_630037</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG06881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037246.1">
        <property type="nucleotide sequence ID" value="XM_018186941.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CI00"/>
    <dbReference type="STRING" id="1460663.A0A177CI00"/>
    <dbReference type="GeneID" id="28770427"/>
    <dbReference type="InParanoid" id="A0A177CI00"/>
    <dbReference type="OrthoDB" id="5022096at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF167">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="53"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="135"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="179"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="215"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="252"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="37"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="317"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="389"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="325"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="406"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAG06881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="420" mass="45668" checksum="4CFF0B242A407BD0" modified="2016-09-07" version="1">MGSEQPKQGAYPQENDGPRVLGVVLGITVFAVITMAARLWVRMKMIRNVGWDDYCMSFATLLVIIGAGIVVPEVHYGCGRHIDQISPEDFKIGFKLNFISQPIYLIAICIVKLSVGFFLLRIATIPFYRHTIQGIMAFMAFYTTGCFFTIMFQCTNLAVQWDQSVKGTCWSKQTIQALGYTNTACNIITDLLFAIVIPIPMLWQVQLNRRQKSSIVCILGLGIFATAAALVKISFLPNYGSTGDWLWDSRNITIWTILETCVGIIAGNLPCLKPLFRTVLGSTYGRGSRGRTGGTGNTPRYLGYGGGTNAASAKAKGFSSLNSSKADRQPHDPYEMKTMGGDERGSGAISPVSVRGDGGSDKSSEGSVELLDTQNAVLRLGGIMKTTEVTQSREATGGVPPSSRAGELELRPERGIRDMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CIH4</accession>
    <name>A0A177CIH4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">FabD/lysophospholipase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CC84DRAFT_1215695</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG06649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037014.1">
        <property type="nucleotide sequence ID" value="XM_018182736.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CIH4"/>
    <dbReference type="STRING" id="1460663.A0A177CIH4"/>
    <dbReference type="GeneID" id="28766222"/>
    <dbReference type="InParanoid" id="A0A177CIH4"/>
    <dbReference type="OrthoDB" id="5430240at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047499">
        <property type="term" value="F:calcium-independent phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019369">
        <property type="term" value="P:arachidonate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046486">
        <property type="term" value="P:glycerolipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07216">
        <property type="entry name" value="Pat17_PNPLA8_PNPLA9_like3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24185">
        <property type="entry name" value="CALCIUM-INDEPENDENT PHOSPHOLIPASE A2-GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24185:SF1">
        <property type="entry name" value="CALCIUM-INDEPENDENT PHOSPHOLIPASE A2-GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 4" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="3 4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PNPLA" evidence="5">
        <location>
            <begin position="291"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXGXXG" evidence="4">
        <location>
            <begin position="295"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXSXG" evidence="4">
        <location>
            <begin position="341"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="DGA/G" evidence="4">
        <location>
            <begin position="498"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="343"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAG06649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="629" mass="70624" checksum="ADB21A5B4E54A308" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CIS4</accession>
    <name>A0A177CIS4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">U-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CC84DRAFT_1117724</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ubiquitin conjugation factor E4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG07415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037780.1">
        <property type="nucleotide sequence ID" value="XM_018175502.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CIS4"/>
    <dbReference type="FunCoup" id="A0A177CIS4">
        <property type="interactions" value="1236"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CIS4"/>
    <dbReference type="GeneID" id="28758988"/>
    <dbReference type="InParanoid" id="A0A177CIS4"/>
    <dbReference type="OrthoDB" id="20295at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034450">
        <property type="term" value="F:ubiquitin-ubiquitin ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000055">
        <property type="entry name" value="Ubiquitin conjugation factor e4 a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019474">
        <property type="entry name" value="Ub_conjug_fac_E4_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045132">
        <property type="entry name" value="UBE4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003613">
        <property type="entry name" value="Ubox_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13931:SF2">
        <property type="entry name" value="UBIQUITIN CONJUGATION FACTOR E4 B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13931">
        <property type="entry name" value="UBIQUITINATION FACTOR E4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04564">
        <property type="entry name" value="U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10408">
        <property type="entry name" value="Ufd2P_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00504">
        <property type="entry name" value="Ubox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51698">
        <property type="entry name" value="U_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0697">Rotamase</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="U-box" evidence="13">
        <location>
            <begin position="979"/>
            <end position="1053"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="521"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="33"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="56"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OAG07415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="1074" mass="121993" checksum="BC0496943ACCAC15" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CIZ5</accession>
    <name>A0A177CIZ5_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DASH complex subunit SPC19</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Outer kinetochore protein SPC19</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CC84DRAFT_1088207</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Centromere</location>
            <location evidence="3">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DASH complex SPC19 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG06757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037122.1">
        <property type="nucleotide sequence ID" value="XM_018174244.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CIZ5"/>
    <dbReference type="FunCoup" id="A0A177CIZ5">
        <property type="interactions" value="19"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CIZ5"/>
    <dbReference type="GeneID" id="28757730"/>
    <dbReference type="InParanoid" id="A0A177CIZ5"/>
    <dbReference type="OrthoDB" id="3361333at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042729">
        <property type="term" value="C:DASH complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005876">
        <property type="term" value="C:spindle microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008608">
        <property type="term" value="P:attachment of spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013251">
        <property type="entry name" value="DASH_Spc19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28262">
        <property type="entry name" value="DASH COMPLEX SUBUNIT SPC19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28262:SF1">
        <property type="entry name" value="DASH COMPLEX SUBUNIT SPC19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08287">
        <property type="entry name" value="DASH_Spc19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0137">Centromere</keyword>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OAG06757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="175" mass="19495" checksum="B4CCC831E1983A76" modified="2016-09-07" version="1">MALEGCVGSLRSSMQLLDSSINILDEATNDFPRLSKVLQTTRHFELISEPDLHSAQSALLSEIRPEVESLLTRVQNYLDKLERREQSLIAKCDLNDGRLGTQDSNAESAFGAKSKGSAGANGKPISAVQEMKYKQLRAKKQRLSYAVETLEMQAKQRERQLRMSMAAPQQLGLED</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CJF9</accession>
    <name>A0A177CJF9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1241947</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG06998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037363.1">
        <property type="nucleotide sequence ID" value="XM_018184071.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CJF9"/>
    <dbReference type="GeneID" id="28767557"/>
    <dbReference type="InParanoid" id="A0A177CJF9"/>
    <dbReference type="OrthoDB" id="440424at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038213">
        <property type="entry name" value="IFI6/IFI27-like_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG06998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="143" mass="15536" checksum="7E743AD78880E6A8" modified="2016-09-07" version="1">MYPFLGDGPETPPPGGPFAARIISAFFTGIMNCIINSIAYLSSILYKYMVDEPFWFAFDIITSALVFIPGACAGAVLRAFGFMRVGPATRNWAARMMSKINPVIARGWYPTCQSAQMGGYGVAIVKRRYSGALSSCYRGSAMC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CK86</accession>
    <name>A0A177CK86_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Thioesterase/thiol ester dehydrase-isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CC84DRAFT_1118170</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the acyl coenzyme A hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG07661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038026.1">
        <property type="nucleotide sequence ID" value="XM_018175513.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CK86"/>
    <dbReference type="STRING" id="1460663.A0A177CK86"/>
    <dbReference type="GeneID" id="28758999"/>
    <dbReference type="InParanoid" id="A0A177CK86"/>
    <dbReference type="OrthoDB" id="331699at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:fatty acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006637">
        <property type="term" value="P:acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03442">
        <property type="entry name" value="BFIT_BACH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.129.10:FF:000032">
        <property type="entry name" value="Acyl-CoA thioester hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.129.10:FF:000038">
        <property type="entry name" value="Acyl-CoA thioester hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033120">
        <property type="entry name" value="HOTDOG_ACOT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12655">
        <property type="entry name" value="ACYL-COA THIOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12655:SF0">
        <property type="entry name" value="ACYL-COENZYME A THIOESTERASE 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51770">
        <property type="entry name" value="HOTDOG_ACOT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="HotDog ACOT-type" evidence="6">
        <location>
            <begin position="103"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="HotDog ACOT-type" evidence="6">
        <location>
            <begin position="300"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="66"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="66"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAG07661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="474" mass="53651" checksum="906C4C59C2E6B4AF" modified="2016-09-07" version="1">MAHLSRITLRRVSRAAECNCARSFLARPATVPATHRAFRTTSPSRTDGVFRELTAQRLQTPWVEALRKQQEESKSGAKKPLAPQVPKERDLTPKRMDDSYHKVVLPLAQDPWLLDTYLNSSGHIRLGTIFMDLDALSGVIAYKHTGDDVTTVTASCDRIVINHPLTEICDLELSGKVTYATGRSSMEITMQVAKAPQEGQTIKNEDVLIHCTMTMVALDPATKKPVNVNPLIVSSPEEKRLYDLGERNSKVRKQRKETALTKHTPNDLESDLIHAFWQKQLQYHDPYDELRKPDNAHFMDTTILRNATIMQPQNRNRHQFMIFGGFLLKQTFELAFTTAAAFAHARPTFVSLDPSTFQNPVPVGSILYMTATVVYTDPPLIGAPDEQFDPQSEYTRVQVRVDSKVRDVEHGRSKPTGTFNYTFTVKKNIRVVPRTYQEFMLYLDARRRAEQVKETLQHEGVGLSAQTAEESVTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CKB8</accession>
    <name>A0A177CKB8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF1783-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1088670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG07412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037777.1">
        <property type="nucleotide sequence ID" value="XM_018174268.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CKB8"/>
    <dbReference type="FunCoup" id="A0A177CKB8">
        <property type="interactions" value="31"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CKB8"/>
    <dbReference type="GeneID" id="28757754"/>
    <dbReference type="InParanoid" id="A0A177CKB8"/>
    <dbReference type="OrthoDB" id="2100652at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014807">
        <property type="entry name" value="Coa1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042432">
        <property type="entry name" value="Coa1_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28523">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28523:SF1">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08695">
        <property type="entry name" value="Coa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG07412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="222" mass="25376" checksum="57CD4DE2D4724845" modified="2016-09-07" version="1">MPPPRLLSPLLRARLQPSYQCLRRTPAVRHASTEPTPPPSALPWKTPQSIEAWPPAYMIPPPKDGEILLERKFNRELPPVPPLIHPSVLRTLPVFIISMTIATLVFFNYQKTESSVVTSTLYALRTNPAVRDMLGDEIYFASKYPWIRGEINQVHGRIDIRFWVKGTKREGEVRLRCKRRGKDGLYITKEWSLTMADGERMELYDPQGNAIDPFAGMDPADQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CL37</accession>
    <name>A0A177CL37_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1257121</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038588.1">
        <property type="nucleotide sequence ID" value="XM_018184698.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CL37"/>
    <dbReference type="GeneID" id="28768184"/>
    <dbReference type="InParanoid" id="A0A177CL37"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="56"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG08223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="107" mass="11805" checksum="C26BD0D983E79231" modified="2016-09-07" version="1">MGHHHSKPDDPPPPPPPDWLPGNCPTLFECNPNGKLAKRAGVIKHVFARAYEKNPATVRCLVCLLVFLVVVGMCITTWCAVAKRQARRKRVQAARVEAEKGGFSSDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CMY2</accession>
    <name>A0A177CMY2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1239417</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038625.1">
        <property type="nucleotide sequence ID" value="XM_018183976.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CMY2"/>
    <dbReference type="STRING" id="1460663.A0A177CMY2"/>
    <dbReference type="GeneID" id="28767462"/>
    <dbReference type="InParanoid" id="A0A177CMY2"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008058383" evidence="2">
        <location>
            <begin position="21"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG08260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="150" mass="14569" checksum="B4E6337706FC1042" modified="2016-09-07" version="1">MKATSYVALAISCFIAGSTSAPTPELIDLTGVVGSIANGNTAGNGNGNGNGIGNGNQAGNNNLINIGLKERGLVDSLAGALGSITKPSAGNGNSNGNGNGDGNSVGNGNQAGNGNTVNLGDVNVPSVTLPEIELPDINLSPSINMARSPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CNJ4</accession>
    <name>A0A177CNJ4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_1215252</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039146.1">
        <property type="nucleotide sequence ID" value="XM_018182707.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CNJ4"/>
    <dbReference type="STRING" id="1460663.A0A177CNJ4"/>
    <dbReference type="GeneID" id="28766193"/>
    <dbReference type="InParanoid" id="A0A177CNJ4"/>
    <dbReference type="OrthoDB" id="420380at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031418">
        <property type="term" value="F:L-ascorbic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004656">
        <property type="term" value="F:procollagen-proline 4-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045054">
        <property type="entry name" value="P4HA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006620">
        <property type="entry name" value="Pro_4_hyd_alph"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869">
        <property type="entry name" value="PROLYL 4-HYDROXYLASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869:SF242">
        <property type="entry name" value="PROLYL 4-HYDROXYLASE ALPHA SUBUNIT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00702">
        <property type="entry name" value="P4Hc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="7">
        <location>
            <begin position="172"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAG08781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="312" mass="34229" checksum="3E5688732153D3C5" modified="2016-09-07" version="1">MAKLIQSQSAVPPSRKASNTGKLELSTAQFLSFSFTLLTLPLLLQTLYTIYFSPYFAPLHAPQNDSSTSINPSSPSLLTACRAHTYTTQIVSLDPLMIYINNFTSGAEAEALIKLGADDFEDSFISRSGGGNQKVSGRTSQSAPLAVEEPLVACIVDRARAFLGTMLHAHEPFSTPQLVRYFQTQRYDLHTDFWPRHQRLSDGSGRLFNRPASFFVFLRDNCTAGETWFPGVSIEDGKEVGLGGRVRRGKDDGDDGKGVTFKPVKGSAVFWVNIGEDGVGDRRVVHAGLPVGEGEKIGMNIWPRKFYAAQDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2023-06-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CNY9</accession>
    <name>A0A177CNY9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_599801</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG09006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039371.1">
        <property type="nucleotide sequence ID" value="XM_018186829.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CNY9"/>
    <dbReference type="GeneID" id="28770315"/>
    <dbReference type="InParanoid" id="A0A177CNY9"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG09006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="65" mass="7395" checksum="0D18D068F868AAAF" modified="2016-09-07" version="1">MTVIASHIFASAQLLIDLTLGPTRWPSYRTRFVRSQKKSTGLVMGPHLHSSLNRDHFMSVELLDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CP77</accession>
    <name>A0A177CP77_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1234687</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG09314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039679.1">
        <property type="nucleotide sequence ID" value="XM_018183824.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CP77"/>
    <dbReference type="STRING" id="1460663.A0A177CP77"/>
    <dbReference type="GeneID" id="28767310"/>
    <dbReference type="InParanoid" id="A0A177CP77"/>
    <dbReference type="OrthoDB" id="10559973at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG09314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="112" mass="12467" checksum="BF1481040D75511E" modified="2016-09-07" version="1">MPTSSWDSSSSDETIRVRQLSPVPAIHNGPGHRFTPVFDRIHSRDDHGISGAAALDATDMAGVNFKHVDRNKYMMNLARNEVDILTEKGDRQTAKATLVNHATIEPPRCIFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CQ52</accession>
    <name>A0A177CQ52_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ubiquitin-protein ligase sel1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1215339</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039242.1">
        <property type="nucleotide sequence ID" value="XM_018182714.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CQ52"/>
    <dbReference type="GeneID" id="28766200"/>
    <dbReference type="InParanoid" id="A0A177CQ52"/>
    <dbReference type="OrthoDB" id="5400539at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020999">
        <property type="entry name" value="Chitin_synth_reg_RCR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12273">
        <property type="entry name" value="RCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="97"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG08877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="194" mass="22215" checksum="B391CED375F1B0A6" modified="2016-09-07" version="1">MELTKRYCVQYLDGTVECFRDGFWYSDTGIIVKWAILASFFLFFMAWFLGGYLHAKARLRKGKPLLAYHRWLVSYQDRKRYGQTTQNRYEYYAQPPYPQQQQQQQQQAYGPRPDGTWPEPPPMYNGDAPPGYVPPPGASKMDPNQAPGNVEMGQYPPPPPMGAQQTGGQSGFQQEMPPRPAQARLAGLLGRFRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CQD7</accession>
    <name>A0A177CQD7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_452646</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG09734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040099.1">
        <property type="nucleotide sequence ID" value="XM_018186322.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CQD7"/>
    <dbReference type="GeneID" id="28769808"/>
    <dbReference type="InParanoid" id="A0A177CQD7"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG09734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="84" mass="9461" checksum="DB4CA08487513422" modified="2016-09-07" version="1">MLAQRTWEVSHLPLKFCSFQDFPGNILLNIGNQLSVEPMSGQTSDPASMPIKLTFPNILLFLSIHVPLLMTACFPKDRLAFQKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CR28</accession>
    <name>A0A177CR28_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_449172</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG09671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040036.1">
        <property type="nucleotide sequence ID" value="XM_018186311.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CR28"/>
    <dbReference type="GeneID" id="28769797"/>
    <dbReference type="InParanoid" id="A0A177CR28"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008058495" description="Secreted protein" evidence="1">
        <location>
            <begin position="27"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG09671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="168" mass="18031" checksum="96E20089DE609EC8" modified="2016-09-07" version="1">MRGMDSLARASMLSSFLLIFSNVILSSSGSSGSSRLVIISESGPPMVGIISMTFPNAARISLRPASSSFLLKSLVVSLGLEPMLPVPLSSSTASFVAKTSAYALTRASISIPLSIAKDKGKNCCKDQVYSRERRRVCCEGHSCHFKYLTNTYRLLSPPQNGQVTYAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CRE4</accession>
    <name>A0A177CRE4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF1749-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1161098</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040458.1">
        <property type="nucleotide sequence ID" value="XM_018177651.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CRE4"/>
    <dbReference type="GeneID" id="28761137"/>
    <dbReference type="InParanoid" id="A0A177CRE4"/>
    <dbReference type="OrthoDB" id="10034502at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013744">
        <property type="entry name" value="SidJ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31591:SF7">
        <property type="entry name" value="DUF1749-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31591">
        <property type="entry name" value="UPF0613 PROTEIN PB24D3.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08538">
        <property type="entry name" value="DUF1749"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG10093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="317" mass="34063" checksum="AC1C69ADA0865930" modified="2016-09-07" version="1">MAQNGTFHPGTLHLYTPSLTAFEHRPPPLNPNCSVSSSSTPQNTILFIGGLGDSPLTVRYPTLLSRTVPPHWTIAEVTLTSSAAGWGTSTLSRDAAELGECVAYFKKMRPSGKIVLMGHSTGCQDVMEYLVGLSSSSRPAIEGAILQAAVSDREGWDTIVSDDASLKESLEKTVAMAGAWVARGDGDAILPKKGNKVLEMFDSPCTAYRAHSLLAKGGDDDYFSTDLSDDTLKGTFGKIPARTKAMFLWGSRDPYIPGHVDQEGTLKRWARIVREGGGNVDEANGGVVRGATHNLNDDAEDIVQDLVGRVVRFIKEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CRR9</accession>
    <name>A0A177CRR9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Glycoside hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CC84DRAFT_1111828</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG09986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040351.1">
        <property type="nucleotide sequence ID" value="XM_018175296.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CRR9"/>
    <dbReference type="STRING" id="1460663.A0A177CRR9"/>
    <dbReference type="GeneID" id="28758782"/>
    <dbReference type="InParanoid" id="A0A177CRR9"/>
    <dbReference type="OrthoDB" id="20872at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036156">
        <property type="entry name" value="Beta-gal/glucu_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054593">
        <property type="entry name" value="Beta-mannosidase-like_N2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051913">
        <property type="entry name" value="GH2_Domain-Containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006103">
        <property type="entry name" value="Glyco_hydro_2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006102">
        <property type="entry name" value="Ig-like_GH2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42732">
        <property type="entry name" value="BETA-GALACTOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42732:SF4">
        <property type="entry name" value="BETA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00703">
        <property type="entry name" value="Glyco_hydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02836">
        <property type="entry name" value="Glyco_hydro_2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22666">
        <property type="entry name" value="Glyco_hydro_2_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49303">
        <property type="entry name" value="beta-Galactosidase/glucuronidase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-mannosidase-like galactose-binding" evidence="6">
        <location>
            <begin position="119"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 2 immunoglobulin-like beta-sandwich" evidence="4">
        <location>
            <begin position="325"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 2 catalytic" evidence="5">
        <location>
            <begin position="409"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF22666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAG09986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="688" mass="77414" checksum="F1625988EAD2C7EF" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CSA9</accession>
    <name>A0A177CSA9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF1748-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1256251</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040780.1">
        <property type="nucleotide sequence ID" value="XM_018184605.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CSA9"/>
    <dbReference type="FunCoup" id="A0A177CSA9">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="GeneID" id="28768091"/>
    <dbReference type="InParanoid" id="A0A177CSA9"/>
    <dbReference type="OrthoDB" id="16824at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013726">
        <property type="entry name" value="Mitofissin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28075">
        <property type="entry name" value="CHROMOSOME 16, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28075:SF1">
        <property type="entry name" value="DUF1748-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08520">
        <property type="entry name" value="Mitofissin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG10415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="74" mass="8349" checksum="ACA04CEDCE7685DE" modified="2016-09-07" version="1">MVLGKVAHYAFDAVLISAFLAGVRRSTGLTVKSENFTETPGLKKWIDNYLWVGEWTMDQSVAVFGTSGYFERKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CTC4</accession>
    <name>A0A177CTC4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Multisynthetase complex auxiliary component p43</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CC84DRAFT_1084873</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040515.1">
        <property type="nucleotide sequence ID" value="XM_018174071.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CTC4"/>
    <dbReference type="FunCoup" id="A0A177CTC4">
        <property type="interactions" value="331"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CTC4"/>
    <dbReference type="GeneID" id="28757557"/>
    <dbReference type="InParanoid" id="A0A177CTC4"/>
    <dbReference type="OrthoDB" id="19141at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017102">
        <property type="term" value="C:methionyl glutamyl tRNA synthetase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd10304">
        <property type="entry name" value="GST_C_Arc1p_N_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02799">
        <property type="entry name" value="tRNA_bind_EMAP-II_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000199">
        <property type="entry name" value="tRNA-aminoacylation cofactor ARC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053836">
        <property type="entry name" value="Arc1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002547">
        <property type="entry name" value="tRNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051270">
        <property type="entry name" value="Tyrosine-tRNA_ligase_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11586:SF33">
        <property type="entry name" value="AMINOACYL TRNA SYNTHASE COMPLEX-INTERACTING MULTIFUNCTIONAL PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11586">
        <property type="entry name" value="TRNA-AMINOACYLATION COFACTOR ARC1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21972">
        <property type="entry name" value="Arc1p_N_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01588">
        <property type="entry name" value="tRNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50886">
        <property type="entry name" value="TRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1 3" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="TRNA-binding" evidence="5">
        <location>
            <begin position="256"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="160"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="160"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="194"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAG10150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="454" mass="47882" checksum="E0F1EF212CC694C0" modified="2016-09-07" version="1">MATATLDESLLAFLKTHAPNNASSETDAVKASQALFPSVTYTDAEKAELSQWLTSAAHVATDGEDAAKAAERLSSLNTHLASRTTVLGGKPSVADIAVYQKLAPVVSNWSAEERTGEQGYHHIVRHVDFVQNSPLFGLKLDNKVNIDLDSVIFKIKPVDAKAEKERKKKEKEAAAANAAASGGATPTTLTGDKAAGDKKSKKENVVDKAQAAGEAVASTVAGKAGGAPDGAPTQKKEKKPKQPKPQKAPPAEKPLSPCLIDLRVGHILKAERHPNADSLYVSTIACGDPAGTDNTSEYEGQVVRTVCSGLNGLIPLEEMQNRKIVTVCNLKPVTMRGIKSCAMVLAASPRVTEGEDSHKGPVELVNPPADSKAGDRVFFEGWEGEPEAVLNPKKKVWETIQPGFTTTDSLEVGFNVEDVPQLSGEGADKKTGVAKLKTAAGLCTVTTLKGATVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CTK1</accession>
    <name>A0A177CTK1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1236697</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040595.1">
        <property type="nucleotide sequence ID" value="XM_018183880.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CTK1"/>
    <dbReference type="STRING" id="1460663.A0A177CTK1"/>
    <dbReference type="GeneID" id="28767366"/>
    <dbReference type="InParanoid" id="A0A177CTK1"/>
    <dbReference type="OrthoDB" id="9930022at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08276">
        <property type="entry name" value="MDR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052711">
        <property type="entry name" value="Zinc_ADH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45033">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45033:SF2">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE PROTEIN C1773.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="1">
        <location>
            <begin position="16"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG10230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="347" mass="36930" checksum="7D9FED96996C66B1" modified="2016-09-07" version="1">MAPSTTKQWTIQGKEGFESLKWDEKAPVPSLGDKDVLVKFHAASLNFRDLAIPKGKYPFPVKEGVIPGSDGAGVVEAVGPNVTRFKVGDKVATLFNQGHLAGSLNPSILGTGLGGVVDGALREYGSFDEQGLVHIPSNLDFAEASTLPCAALTAWNALYGLKKLEPGQTVLTQGTGGVSIFALQFAKAAGARVIATTSSPEKAEILKKLGADHVINYKENPNWGEQAQSLSPGGLGVDHVVEVGGPTTMKQSLVAIKIDGVISIIGFIGGFSKDQPSFLDCLNNICTVRGLLVGSRQQFEDMNAAIEANDIHPIVDNKVFTLPELKEAYQYMFDQKHFGKLAIKIAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CTR4</accession>
    <name>A0A177CTR4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Alpha/beta-hydrolase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1184571</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040946.1">
        <property type="nucleotide sequence ID" value="XM_018180756.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CTR4"/>
    <dbReference type="GeneID" id="28764242"/>
    <dbReference type="InParanoid" id="A0A177CTR4"/>
    <dbReference type="OrthoDB" id="190201at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008058576" description="Alpha/beta-hydrolase" evidence="1">
        <location>
            <begin position="19"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG10581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="335" mass="36540" checksum="08FF4E99A51A230B" modified="2016-09-07" version="1">MAAFASLGALRLAGFATANTYSNFSIPIEISSRQGVFPNQGRNYFAKILEGYATVQGQYEISAKYCQPDDGNASTIQIFYWDLAYNNYNYSYVKVANAAGYSTLAIYRLVIGNSSHGEPINKIQAQLKVEALNAVTTLLRAGKIPEIKKRYGKIIHVGHSFGSIQSYWLSALYRNNTDGLTVPAWNLHSARLNQPLFFADAPNSKLRAVFSGWFKNSSLIQAHQTLLKVSHCDLTANQLVFLRYGAYDIGLGVITEQTEQPVTIGKLLTTGGAPAEDSFGGPVIIFTGEFDEAFCGLDCYATGGSNTGHRINVHYNSTAGNEYVQRWLAANGPGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CTU1</accession>
    <name>A0A177CTU1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Mitochondrial carrier protein-like protein rim2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CC84DRAFT_1112728</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040803.1">
        <property type="nucleotide sequence ID" value="XM_018175328.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CTU1"/>
    <dbReference type="FunCoup" id="A0A177CTU1">
        <property type="interactions" value="437"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CTU1"/>
    <dbReference type="GeneID" id="28758814"/>
    <dbReference type="InParanoid" id="A0A177CTU1"/>
    <dbReference type="OrthoDB" id="269120at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015218">
        <property type="term" value="F:pyrimidine nucleotide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990519">
        <property type="term" value="P:pyrimidine nucleotide import into mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049562">
        <property type="entry name" value="SLC25A33/36-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45829">
        <property type="entry name" value="MITOCHONDRIAL CARRIER PROTEIN RIM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45829:SF4">
        <property type="entry name" value="MITOCHONDRIAL CARRIER PROTEIN RIM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 10" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="52"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="173"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="286"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="19"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="29"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OAG10438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="382" mass="42031" checksum="C21DA13FFA6FCD9C" modified="2016-09-07" version="1">MTLDHAPRPRSIHDDGTPFKQTLLPQSRETGDVIPQKRPDGTPVATAESPFAKSWAHFIAGGLGGMASATLTAPLDVLKTRLQSTYYQQHLAAMRTARGLPPIETMSFARSSLLHIRETGEILWQVPKTEGWRALFKGLGPNLIGVVPARAINFYAYGNGKRIISNQFNDGKESAMVHLFAAACAGIVTGTATNPIWLVKTRLQLDKNTHADGRGRQYKNALDCTMQTIRKEGIRGLYRGLTASYLGVTESTLQWMMYEQMKLALARREERVAASGRPPTTWDQTVSWTGKVSAAGVAKFVAALITYPHEVVRTRLRQAPLENGQLKYTGLTQCFKLIWKEEGMAALYGGLVPHMFRVVPSAAIMFGTYEAVLKLLGTSSNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CU85</accession>
    <name>A0A177CU85_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Pectinesterase</fullName>
            <ecNumber evidence="4 11">3.1.1.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CC84DRAFT_1238408</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Involved in maceration and soft-rotting of plant tissue.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 11">
            <text>[(1-&gt;4)-alpha-D-galacturonosyl methyl ester](n) + n H2O = [(1-&gt;4)-alpha-D-galacturonosyl](n) + n methanol + n H(+)</text>
            <dbReference type="Rhea" id="RHEA:22380"/>
            <dbReference type="Rhea" id="RHEA-COMP:14570"/>
            <dbReference type="Rhea" id="RHEA-COMP:14573"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17790"/>
            <dbReference type="ChEBI" id="CHEBI:140522"/>
            <dbReference type="ChEBI" id="CHEBI:140523"/>
            <dbReference type="EC" id="3.1.1.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Glycan metabolism; pectin degradation; 2-dehydro-3-deoxy-D-gluconate from pectin: step 1/5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the pectinesterase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.11" evidence="4 11"/>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG11094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041459.1">
        <property type="nucleotide sequence ID" value="XM_018183937.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CU85"/>
    <dbReference type="STRING" id="1460663.A0A177CU85"/>
    <dbReference type="GeneID" id="28767423"/>
    <dbReference type="InParanoid" id="A0A177CU85"/>
    <dbReference type="OrthoDB" id="2019149at2759"/>
    <dbReference type="UniPathway" id="UPA00545">
        <property type="reaction ID" value="UER00823"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030599">
        <property type="term" value="F:pectinesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042545">
        <property type="term" value="P:cell wall modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045490">
        <property type="term" value="P:pectin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.10:FF:000014">
        <property type="entry name" value="Pectinesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033131">
        <property type="entry name" value="Pectinesterase_Asp_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000070">
        <property type="entry name" value="Pectinesterase_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31321">
        <property type="entry name" value="ACYL-COA THIOESTER HYDROLASE YBHC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31321:SF57">
        <property type="entry name" value="PECTINESTERASE 53-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01095">
        <property type="entry name" value="Pectinesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00503">
        <property type="entry name" value="PECTINESTERASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0063">Aspartyl esterase</keyword>
    <keyword evidence="11" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007948987" description="Pectinesterase" evidence="11">
        <location>
            <begin position="18"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="Pectinesterase catalytic" evidence="12">
        <location>
            <begin position="44"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OAG11094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="329" mass="34737" checksum="C020EFDCF8ED3225" modified="2016-09-07" version="1">MKISSFLIFLASGLGLASVSPLTKRAGRTGPPSGCKVVRGSGTQSGEYTTLGAAITALGTSATVSACIFIYSGTYTEQVVVQYKGPLSIYGYTTDISSYKNNAVTITHELSSPNAGSLDASATINVKSSSFALYNVNVANTYGKGAQAVALVANGSKQGYYGVSFKGYQDTLYAKSGDQYYSNCYIEGAVDYIFGDASAWFGECTIASTGSGAITATSRETSSDPAWYVFDHSTITAATGASVTGMVYLGRPWRVLSRVMYQNSVLTNVVNAKGWTEMADGATPLYYEYKNSGDGANTSGRKYLSASSAAVTKAQIWPNSGIDWYDKSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CUC0</accession>
    <name>A0A177CUC0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_486123</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the cyclin family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040845.1">
        <property type="nucleotide sequence ID" value="XM_018186463.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CUC0"/>
    <dbReference type="STRING" id="1460663.A0A177CUC0"/>
    <dbReference type="GeneID" id="28769949"/>
    <dbReference type="InParanoid" id="A0A177CUC0"/>
    <dbReference type="OrthoDB" id="5590282at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044843">
        <property type="term" value="P:cell cycle G1/S phase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd20537">
        <property type="entry name" value="CYCLIN_CCNO-like_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20559">
        <property type="entry name" value="CYCLIN_ScCLN_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000010">
        <property type="entry name" value="G1/S-specific cyclin Cln1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000065">
        <property type="entry name" value="G1/S-specific cyclin Cln1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039361">
        <property type="entry name" value="Cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004367">
        <property type="entry name" value="Cyclin_C-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048258">
        <property type="entry name" value="Cyclins_cyclin-box"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10177">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02984">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01332">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00292">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="3 5" id="KW-0195">Cyclin</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="6">
        <location>
            <begin position="97"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin C-terminal" evidence="7">
        <location>
            <begin position="192"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin-like" evidence="6">
        <location>
            <begin position="196"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAG10480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="405" mass="46442" checksum="5FA69A13D268FD52" modified="2016-09-07" version="1">MAFRQPMSRYGQCTSYFVETQDDGLYAARAEERDRARAIARMQQRALAEELSRLTADEYQDDIMDHMEYMESQTLPDVNSIDIQTEIQWFMRPYLLDFLVEAHAAFQLLPETLFLAVNLLDRYCSRRVVYKRHYQLVGCAALLIAAKYGDKKDRVPTVRELKSMCCSLYDDEMFTQMEWHVLQTLNWIIGHPTVDAFLQVALAEGPYDPEVEHMSLYIAEIALFHKEFVSTRPSILARSSLALARCILSRNDHKVSEWAATYDPQTVMSLSNHLYQPSQVLSRKYSSMHLSNVSTTVDEFLQRQAQIARRAAAPPTPPASVGLEEPKSMIDAYGPQTPQKTHYSASVMQHGCLTPPITPENEQYVAKSHPMPPTTYPTTPTPEHPANMHQAQYYQNTYIQPQPQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CV86</accession>
    <name>A0A177CV86_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Serine/threonine kinase 16</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CC84DRAFT_500618</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041293.1">
        <property type="nucleotide sequence ID" value="XM_018186547.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CV86"/>
    <dbReference type="STRING" id="1460663.A0A177CV86"/>
    <dbReference type="GeneID" id="28770033"/>
    <dbReference type="InParanoid" id="A0A177CV86"/>
    <dbReference type="OrthoDB" id="2585655at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF29">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G06680)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="139"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="206"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="232"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="332"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="376"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="416"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="445"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="516"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAG10928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="553" mass="60528" checksum="4DC6D225D30A41AD" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CVR1</accession>
    <name>A0A177CVR1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_1106724</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG11326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041691.1">
        <property type="nucleotide sequence ID" value="XM_018175154.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A177CVR1">
        <property type="interactions" value="973"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CVR1"/>
    <dbReference type="GeneID" id="28758640"/>
    <dbReference type="InParanoid" id="A0A177CVR1"/>
    <dbReference type="OrthoDB" id="360653at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052575">
        <property type="entry name" value="SSU_processome_comp_20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046523">
        <property type="entry name" value="UTP20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011430">
        <property type="entry name" value="UTP20_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17695">
        <property type="entry name" value="SMALL SUBUNIT PROCESSOME COMPONENT 20 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17695:SF11">
        <property type="entry name" value="SMALL SUBUNIT PROCESSOME COMPONENT 20 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20416">
        <property type="entry name" value="UTP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07539">
        <property type="entry name" value="UTP20_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="U3 small nucleolar RNA-associated protein 20 N-terminal" evidence="2">
        <location>
            <begin position="879"/>
            <end position="1475"/>
        </location>
    </feature>
    <feature type="domain" description="U3 small nucleolar RNA-associated protein 20" evidence="3">
        <location>
            <begin position="1696"/>
            <end position="1914"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1631"/>
            <end position="1652"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2440"/>
            <end position="2465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2586"/>
            <end position="2636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1633"/>
            <end position="1647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="2609"/>
            <end position="2624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="2625"/>
            <end position="2636"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAG11326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="2636" mass="296482" checksum="EF8C070B6034DFCC" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CVW7</accession>
    <name>A0A177CVW7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1080825</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG11361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041726.1">
        <property type="nucleotide sequence ID" value="XM_018173909.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CVW7"/>
    <dbReference type="STRING" id="1460663.A0A177CVW7"/>
    <dbReference type="GeneID" id="28757395"/>
    <dbReference type="InParanoid" id="A0A177CVW7"/>
    <dbReference type="OrthoDB" id="552755at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037647">
        <property type="entry name" value="HIRIP3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15410">
        <property type="entry name" value="HIRA-INTERACTING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15410:SF2">
        <property type="entry name" value="HIRA-INTERACTING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="338"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="383"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="405"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG11361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="415" mass="44833" checksum="FC7128C5C9911790" modified="2016-09-07" version="1">MSHSETEVPSKAAVSRAIRDVVITIHKAGDDDNLTVNHVRTEAEQKLGLSAGFLKKDEWKNESKTMIKEAVDRYCGDEAAPEPSPMKPSKAQPKAKPEPKKMAKKSAFDNASRGVKRKAPAPAKKLHKRKKTVSSDEESEAALSDSPVEDEASDAESEPAKKPARRQKQVVAEDSDEEDVAPPKSRPQGKNEAADREEDTKRPATPPLAAKDEGGDSDLSSVIDDSPVKKRKRNTEKPAKAVSGAKAKAQPKAKAAKTEDDPDQAEIKRLQGWLVKCGIRKVWGKELAKCDTSKDKIRHLKGMLNDAGMDGKYSVEKAAKIKEQREFAKDLEEIQAGAAAWGDSISTGRPRRAAARAAPPVILAEDSDDEDEEKAPGVKDDGTDGDDDDDDVHSDSGSDDSAGGQDDEDGDEDSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CW42</accession>
    <name>A0A177CW42_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">p-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CC84DRAFT_1214226</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041314.1">
        <property type="nucleotide sequence ID" value="XM_018182611.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CW42"/>
    <dbReference type="FunCoup" id="A0A177CW42">
        <property type="interactions" value="648"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CW42"/>
    <dbReference type="GeneID" id="28766097"/>
    <dbReference type="InParanoid" id="A0A177CW42"/>
    <dbReference type="OrthoDB" id="1721884at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050052">
        <property type="entry name" value="ATP-dep_Clp_protease_ClpX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48102:SF7">
        <property type="entry name" value="ATP-DEPENDENT CLP PROTEASE ATP-BINDING SUBUNIT CLPX-LIKE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48102">
        <property type="entry name" value="ATP-DEPENDENT CLP PROTEASE ATP-BINDING SUBUNIT CLPX-LIKE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10431">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="4">
        <location>
            <begin position="182"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="Clp ATPase C-terminal" evidence="5">
        <location>
            <begin position="462"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="48"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="294"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="300"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAG10949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="603" mass="65807" checksum="BD4AB32C121C8B00" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CW48</accession>
    <name>A0A177CW48_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CC84DRAFT_1200728</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG11456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041821.1">
        <property type="nucleotide sequence ID" value="XM_018181679.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CW48"/>
    <dbReference type="STRING" id="1460663.A0A177CW48"/>
    <dbReference type="GeneID" id="28765165"/>
    <dbReference type="InParanoid" id="A0A177CW48"/>
    <dbReference type="OrthoDB" id="10017208at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF47">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="111"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="159"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="192"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="232"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="30"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="273"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="277"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAG11456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="313" mass="34365" checksum="F679CDAAE059548F" modified="2016-09-07" version="1">MLSIPPAPLGIAAVAIAAVFVFLDIAAVSLRLWAKKIKQRPLDATDYLILGALFFATVDMITKGFGKYYVSFDDAITFAQYFIWGITILLIKLSILLLYRGIFHCMVYTLVAIYASMAICVGIWILQIGILFGSCQPLAVNWDPSVPGSCYFKGVSEYVISMSTNLAMDVVLVLIPAPEVWRLKHISVKKKIGISCVFGLGILTCILVGLRFKYLYEMNMADATHDGVPSGIISSVELYLGIICACLPIMPPAFVQAGKKMQSSYAAGLLTRKTSKDSSLGSQKPEQTAVDSKEPDYDQIELNSWPPRTQHEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CW79</accession>
    <name>A0A177CW79_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1238336</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG11067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041432.1">
        <property type="nucleotide sequence ID" value="XM_018183936.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CW79"/>
    <dbReference type="GeneID" id="28767422"/>
    <dbReference type="InParanoid" id="A0A177CW79"/>
    <dbReference type="OrthoDB" id="3718796at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008058660" evidence="1">
        <location>
            <begin position="17"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG11067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="151" mass="16604" checksum="2D259C0CFA4A0EE1" modified="2016-09-07" version="1">MNAFMFLFTFVASVLGLPHVAMIDTPAIRDVGLIFDDRYYKGNSTFIFELRDKPTCIPINVDSQNRPRGFSIKSVQVCKPTTCAFFTGDKCTSKSTGTFSVTCKGPGDVPNHDSNDVYKSYICGQNISKRGSLEDTKALVTVPHNFNAGMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CWP8</accession>
    <name>A0A177CWP8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1170507</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG11631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041996.1">
        <property type="nucleotide sequence ID" value="XM_018179860.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CWP8"/>
    <dbReference type="GeneID" id="28763346"/>
    <dbReference type="InParanoid" id="A0A177CWP8"/>
    <dbReference type="OrthoDB" id="3769559at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.80">
        <property type="entry name" value="E3 ubiquitin-protein ligase SopA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141571">
        <property type="entry name" value="Pentapeptide repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008058686" evidence="2">
        <location>
            <begin position="21"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG11631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="214" mass="22333" checksum="28C271A79A8E3BC1" modified="2016-09-07" version="1">MRSVLAFVAVVLSMALGISAAPLAWDSGSAASQIERDLSGLRRSADPAAADLSGLKRSSTDLSGLKRSSTDFSGLKERSSTDLSGLKRWIIELVERASTDLSGLKRAATDLSGLKRSTADLSGLKRSATDLSGLKRATTDLSGLKRSTTDLSGLKRAATDLSGLKRSTTDLSGLKRATTDLSGLKRSTTDLSGLKRSTTDLSGLKRSGTDLSGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CWR3</accession>
    <name>A0A177CWR3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1159004</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG11478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041843.1">
        <property type="nucleotide sequence ID" value="XM_018177113.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CWR3"/>
    <dbReference type="GeneID" id="28760599"/>
    <dbReference type="InParanoid" id="A0A177CWR3"/>
    <dbReference type="OrthoDB" id="3799226at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008058743" evidence="2">
        <location>
            <begin position="18"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="234"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG11478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="264" mass="27726" checksum="8910CA754AC2D02A" modified="2016-09-07" version="1">MRYSILFLTTILPVSLAAPIASTHQIQPPARLNRRSFTAREERYTQPDGGFPVPPVAPAPGAPAPGRFSGPDGGWVKRQSAEPDVWTPPGPRNGVSDGGSAAVPAPTEVYVPPSIPAPTEVYSPPSVPAPTEAAPPPSNIGWSIATRQDRYTQPDGGFYVPPPAPVAPVDPAPGRYDSPDGGWAKRQDRYTQPDGGFYAPPPAPVAPVDPAPGRYDSPDGGWAKRQDRYTQPDGGFYVAPAPVAPGPVEAVPGRYEGVDGGWKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CX07</accession>
    <name>A0A177CX07_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">CheY-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CC84DRAFT_66691</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042450.1">
        <property type="nucleotide sequence ID" value="XM_018187078.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CX07"/>
    <dbReference type="STRING" id="1460663.A0A177CX07"/>
    <dbReference type="GeneID" id="28770564"/>
    <dbReference type="InParanoid" id="A0A177CX07"/>
    <dbReference type="OrthoDB" id="3751929at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45339">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45339:SF1">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="Response regulatory" evidence="5">
        <location>
            <begin position="28"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="3">
        <location>
            <position position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAG12085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="158" mass="17625" checksum="76E59CB5D8336EC3" modified="2016-09-07" version="1">MAQPTIEASTQQQPRPNLRPKVGSTGIFVLIVEDNHINRIVCLKVLERQGHTVATVGNGQEALDFLCKTSGNRQPNLVFMDTSMPVMDGYEATRRIRRDAGMFDERMRTVPIIGLTANALRGVREQILEAGMDDYIAAPIRPRDLQVAVMRWISPKGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CXH9</accession>
    <name>A0A177CXH9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RTA1 like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CC84DRAFT_1078291</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042639.1">
        <property type="nucleotide sequence ID" value="XM_018173795.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CXH9"/>
    <dbReference type="STRING" id="1460663.A0A177CXH9"/>
    <dbReference type="GeneID" id="28757281"/>
    <dbReference type="InParanoid" id="A0A177CXH9"/>
    <dbReference type="OrthoDB" id="4521223at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007568">
        <property type="entry name" value="RTA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465:SF9">
        <property type="entry name" value="SPHINGOID LONG-CHAIN BASE TRANSPORTER RSB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04479">
        <property type="entry name" value="RTA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="71"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="186"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAG12274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="230" mass="25942" checksum="0474C5987198D987" modified="2016-09-07" version="1" fragment="single">CAVEESIYRYHPSLPANAAFAALFLIATIVHFVLGLRWKTPWVMWCTVLSCTHEVAGYIARVLLYINPWNFGAFITQILCITQAPVFYCAAIYVMLGQRHVHTGHQLLRLRPRTLPCQVFRVNISSLRNRLSAASSGDDNNGVRIAMAGLIFQVVTLVAFSALFADLIFRLLSYEHAKKLTRRDGLFFVFLILAILLTLVGCTFRAYELKEGYKGELITHEDLFIALEGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177D0G8</accession>
    <name>A0A177D0G8_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">TATA element modulatory factor 1 TATA binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CC84DRAFT_1160261</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG13016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018043381.1">
        <property type="nucleotide sequence ID" value="XM_018177457.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177D0G8"/>
    <dbReference type="STRING" id="1460663.A0A177D0G8"/>
    <dbReference type="GeneID" id="28760943"/>
    <dbReference type="InParanoid" id="A0A177D0G8"/>
    <dbReference type="OrthoDB" id="74178at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052602">
        <property type="entry name" value="Growth_transcription_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022092">
        <property type="entry name" value="TMF_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022091">
        <property type="entry name" value="TMF_TATA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46515:SF1">
        <property type="entry name" value="TATA ELEMENT MODULATORY FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46515">
        <property type="entry name" value="TATA ELEMENT MODULATORY FACTOR TMF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12329">
        <property type="entry name" value="TMF_DNA_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12325">
        <property type="entry name" value="TMF_TATA_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TATA element modulatory factor 1 TATA binding" evidence="6">
        <location>
            <begin position="759"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="44"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="263"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="632"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="310"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="538"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="772"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="60"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="72"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="130"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="152"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="188"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="263"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="677"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="688"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="708"/>
            <end position="736"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAG13016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="874" mass="97372" checksum="BFF0EDC743A5DAB3" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BTB9</accession>
    <name>A0A177BTB9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1191749</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441566">
        <property type="protein sequence ID" value="OAF98554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018028920.1">
        <property type="nucleotide sequence ID" value="XM_018181202.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BTB9"/>
    <dbReference type="STRING" id="1460663.A0A177BTB9"/>
    <dbReference type="GeneID" id="28764688"/>
    <dbReference type="InParanoid" id="A0A177BTB9"/>
    <dbReference type="OrthoDB" id="6359816at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843:SF5">
        <property type="entry name" value="BTB_POZ DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="20"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAF98554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="204" mass="22661" checksum="753682F8F7312F66" modified="2016-09-07" version="1">MAAENFIHDLSGYLFAGNLSDLTLTFGETSWQVHRALACCHSIWFQKAVNIGFKASVITLHDDPEFADAIDCMVSYFYKAGYDVSQYDTSESLLHAQVATIADKYDCASLYKLARTSFTDTVNAVESNDWFAVAALIYDHTTPDLSAHKELRGLVVAAVADRPDVLKEILQLESTAGFLRSNADLATDLLLSRKRELEDEHKEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BUS2</accession>
    <name>A0A177BUS2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Flavin oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CC84DRAFT_1200270</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NADH:flavin oxidoreductase/NADH oxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441563">
        <property type="protein sequence ID" value="OAF99054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029420.1">
        <property type="nucleotide sequence ID" value="XM_018181655.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BUS2"/>
    <dbReference type="STRING" id="1460663.A0A177BUS2"/>
    <dbReference type="GeneID" id="28765141"/>
    <dbReference type="InParanoid" id="A0A177BUS2"/>
    <dbReference type="OrthoDB" id="1663137at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051799">
        <property type="entry name" value="NADH_flavin_oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43656">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G08260)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43656:SF2">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G08260)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:flavin oxidoreductase/NADH oxidase N-terminal" evidence="5">
        <location>
            <begin position="7"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAF99054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="426" mass="45608" checksum="413306C0D0D55044" modified="2016-09-07" version="1">MSAQLNRPLKTPSGVVFRNRLVKAAMAESLAAADNDPTDAYITLYDTWSQGDWGAVITGEMEVSTTYMGHPYNINTKPAPSQTRAIKDKWTRWARAATQHGTPALVQLVHPGRQSPAACGQRSFFSKAIAPSAVAVSLGPGASDWLASKLLFGTPRAMSRDEISEAVSQFAAAAKLCHESGFSGVQIHAAHGFLLTQFLSPSTNLRTDEYGGSPAARARIVLEVIRAVRAAVPPSFCVGIKLNSADVGGREAESLEESLEQVGLVAREGIDFLEISGGTLENMRMAAGDAPAPMEKEMSESTRHREAFFLDYARAVRARFPEVVLMVTGGFRSRAGMREALDTGACDLIGLARPSAVWPRLPREVLLNEEVDDGDARCELSLVKGNWFVRNLAPKIVGVGVDTLYYAGQIAMMAEGKGTSAPGLGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BVA0</accession>
    <name>A0A177BVA0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1158581</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441565">
        <property type="protein sequence ID" value="OAF98651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029017.1">
        <property type="nucleotide sequence ID" value="XM_018177054.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BVA0"/>
    <dbReference type="GeneID" id="28760540"/>
    <dbReference type="InParanoid" id="A0A177BVA0"/>
    <dbReference type="OrthoDB" id="5424021at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAF98651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="160" mass="17990" checksum="E1A05CE18DC19438" modified="2016-09-07" version="1">MATPTVWANYVPPRGQCNYKPSIMSAKCPCLRFMLHPLKSTSSFECDGCAHHASFHSMENKEEDEIRKRWEQEARDKAHWEQQGGLDRPRKRPREINYGRGDAASSQVRTIEAGIATPDEETASKSGSARVVAKGKGKGLRAKGRITEIPEDDEDYIELD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BVD5</accession>
    <name>A0A177BVD5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1169989</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441565">
        <property type="protein sequence ID" value="OAF98618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018028984.1">
        <property type="nucleotide sequence ID" value="XM_018179804.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BVD5"/>
    <dbReference type="STRING" id="1460663.A0A177BVD5"/>
    <dbReference type="GeneID" id="28763290"/>
    <dbReference type="InParanoid" id="A0A177BVD5"/>
    <dbReference type="OrthoDB" id="3509362at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08276">
        <property type="entry name" value="MDR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052711">
        <property type="entry name" value="Zinc_ADH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45033">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45033:SF1">
        <property type="entry name" value="OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="1">
        <location>
            <begin position="38"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAF98618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="315" mass="33641" checksum="948F62493394C387" modified="2016-09-07" version="1">MGLYNHHKSVEHPPALVPCSDMCGVVVAVGPCSKKTSDPLKNPAFQLKEGDRVISTFAATHLTGQVQASDVANGLGGPAPGVLTQYRVFPTYNVVKIPDYLTAEEASCLPIAAMTAWMSLNCMRPQGEIIGANETVVCQGTGGVSIAALQIAAAAGASVIVTSSSDSKLQRAQKLGAQTLVNYNSMPDWEASVLKATGDAGADVILEVGGAKTLRKSFDCVKFGGLIACIGYLSGKVDDDTDRTNTNLLCLRRNVTLKGILNGPRDRLEEMLRFYSDKEIRPVVDRVFKFEEGVEALKYLYSGGHFGKVVIQVKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BVS6</accession>
    <name>A0A177BVS6_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">L-serine ammonia-lyase</fullName>
            <ecNumber evidence="5">4.3.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CC84DRAFT_1170020</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-serine = pyruvate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:19169"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="EC" id="4.3.1.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the serine/threonine dehydratase family.</text>
    </comment>
    <dbReference type="EC" id="4.3.1.17" evidence="5"/>
    <dbReference type="EMBL" id="KV441565">
        <property type="protein sequence ID" value="OAF98657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029023.1">
        <property type="nucleotide sequence ID" value="XM_018179814.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BVS6"/>
    <dbReference type="FunCoup" id="A0A177BVS6">
        <property type="interactions" value="457"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177BVS6"/>
    <dbReference type="GeneID" id="28763300"/>
    <dbReference type="InParanoid" id="A0A177BVS6"/>
    <dbReference type="OrthoDB" id="7773036at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003941">
        <property type="term" value="F:L-serine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004794">
        <property type="term" value="F:threonine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006565">
        <property type="term" value="P:L-serine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006567">
        <property type="term" value="P:L-threonine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06448">
        <property type="entry name" value="L-Ser-dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000040">
        <property type="entry name" value="L-serine dehydratase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050147">
        <property type="entry name" value="Ser/Thr_Dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000634">
        <property type="entry name" value="Ser/Thr_deHydtase_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48078:SF2">
        <property type="entry name" value="CATABOLIC L-SERINE_THREONINE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48078">
        <property type="entry name" value="THREONINE DEHYDRATASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00165">
        <property type="entry name" value="DEHYDRATASE_SER_THR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="9" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="11">
        <location>
            <begin position="15"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OAF98657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="339" mass="35986" checksum="C42608AEEE051B0C" modified="2016-09-07" version="1">MTSLQQSPALPCPWRETPLNRSTLLSKHAGCQVYLKLENLQPSGSFKSRGIGNFLRSHLASANAEDRHLTHFYSSSGGNAGLACVHAAVTLGAAATIVVPMTTSAYTMDKMRAAGATEVLQEGASWYECDQYLRETVIPRAKEAGEIPVYVPPFDASEIWEGHATLVGETLAQMNQDGPPDAIVCSVGGGGLFCGIVQGLERAGLENVPVLAVETEGAHSLALSLDKGELSTLPGITSIATTLGARTVAPQAFEYGQRPNVTSVVLPDHAAKEGCVRFADDERIMVEAACGVSMALCYGGRLKKYLPNLTEKSKVVFVVCGGSNITAEMLSKWTAELKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BVX1</accession>
    <name>A0A177BVX1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Membrane-associated proteins in eicosanoid and glutathione metabolism</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CC84DRAFT_1103730</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441561">
        <property type="protein sequence ID" value="OAF99643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030009.1">
        <property type="nucleotide sequence ID" value="XM_018175026.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BVX1"/>
    <dbReference type="STRING" id="1460663.A0A177BVX1"/>
    <dbReference type="GeneID" id="28758512"/>
    <dbReference type="InParanoid" id="A0A177BVX1"/>
    <dbReference type="OrthoDB" id="19091at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.550">
        <property type="entry name" value="Membrane associated eicosanoid/glutathione metabolism-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023352">
        <property type="entry name" value="MAPEG-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001129">
        <property type="entry name" value="Membr-assoc_MAPEG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35814">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35814:SF1">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01124">
        <property type="entry name" value="MAPEG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161084">
        <property type="entry name" value="MAPEG domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="125"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAF99643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="150" mass="16917" checksum="D0BB4063C6E14836" modified="2016-09-07" version="1">MTSFPTSRIGLNLTPATASWTVPFAAYYLFLQNRIVYQRLTTQTYMGDTIDASNGNEDPLYVCTRAQQNFNENIPLTLIIAGLAELNGADRKYINYFLGAMLAFRISHVELGLMRPKSMGVGRIIGYYGTQASLLTMSAYLFYTVKDYFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BW04</accession>
    <name>A0A177BW04_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CC84DRAFT_1200010</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441562">
        <property type="protein sequence ID" value="OAF99295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029661.1">
        <property type="nucleotide sequence ID" value="XM_018181647.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BW04"/>
    <dbReference type="GeneID" id="28765133"/>
    <dbReference type="InParanoid" id="A0A177BW04"/>
    <dbReference type="OrthoDB" id="3639251at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000394">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000018">
        <property type="entry name" value="MFS transporter permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF47">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="48"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="85"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="177"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="211"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="279"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="320"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="344"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="369"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="403"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="436"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="48"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAF99295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="481" mass="53508" checksum="EED2C7C62E7F43F0" modified="2016-09-07" version="1">MLIDEKTDVDHVEKAHIPPAHSDNDATPEQDWTAEEERAIVKKADWRVFPMLCIVFGLSLLDRTNISSAYIAGLATDLQLTGQRYNIALLVFFIGYCLFELPSNYVIRRLGARLWLSFLIIAWGACVLSMGFVQSWEVLTVLRAFLGVFEAGLFPGAVYIIGSWYRQFETAKRVSIFYMAALLASGFGPIFAYALSLISVGDGLYSQGWRWIFIIEGIATVVAGLIAPFFLIEFPEKVRFLTDRQKHIAITRVSLEKAGQQTAHATVAETLRMIWDWKLLMYSIQYFVAASSVYSLAFFQPIILRQGMGFSYAKAQLLSSPPYIFTVFASLGTSWLSDRLRLRWPILVGQSVIAIVGLLLVLYPQPPAARYFGLFLATWGTQGNVPASLAYGNNQTARVSKRAVVAAVMISVGAAGGVTGSTIFQAKDAPQYLPGMWATIAMQILYSIVTICMSMYFKRQNRLADETGKTLEGVEGFRYAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BX84</accession>
    <name>A0A177BX84_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ALDH-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1156450</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441561">
        <property type="protein sequence ID" value="OAF99560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029926.1">
        <property type="nucleotide sequence ID" value="XM_018176975.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BX84"/>
    <dbReference type="STRING" id="1460663.A0A177BX84"/>
    <dbReference type="GeneID" id="28760461"/>
    <dbReference type="InParanoid" id="A0A177BX84"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004777">
        <property type="term" value="F:succinate-semialdehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009450">
        <property type="term" value="P:gamma-aminobutyric acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050740">
        <property type="entry name" value="Aldehyde_DH_Superfamily"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43353:SF6">
        <property type="entry name" value="CYTOPLASMIC ALDEHYDE DEHYDROGENASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43353">
        <property type="entry name" value="SUCCINATE-SEMIALDEHYDE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="2">
        <location>
            <begin position="31"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAF99560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="495" mass="52686" checksum="D6E4650632BB15DD" modified="2016-09-07" version="1">MPFITHPLSPDSLPVVPLWINGKAHPSSEDEILFPVISSVQDKPIHYAVSASPKVAVLAVEAAATALVEWRKTTPAHRRSLILKAADVLEKKSKEVMQAQVAETSCPEMFAKFNMGSVAWMREIASATTEIRGVVTQNATGEGGADVGGLTVTVREPVGVVMIIPPWNGAVILPVRALSMALAAGCTVVVKASELSPRTHHLLLEAFEEAGIPSGVINMIQARREDAAAVTEAIVAHKSLRKVDFIGSAAVGSKIGQLCAKYLKPVLMELGGKGPAVVLEDADLQQAAKMCAMGAVADHGQLCFSTERIIVHRAVYDEFVKYLTAIFSHIPTAGDAVTKESAKHAYDVLSDAQDKGATFLVGGLEYLSETSLKPTLVTNVSRDARIFDEETFGPTATVYMAEDDDDAVEKANDSAYGLNAAVHSKSWERGYEIAKRLEYGQVHINNVTCSDAPGAPIKGVKGSGWGSSNSIWGINEFSIEKSVFLHPSGGASMIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BXA3</accession>
    <name>A0A177BXA3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1181230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441561">
        <property type="protein sequence ID" value="OAF99765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030131.1">
        <property type="nucleotide sequence ID" value="XM_018180539.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BXA3"/>
    <dbReference type="GeneID" id="28764025"/>
    <dbReference type="InParanoid" id="A0A177BXA3"/>
    <dbReference type="OrthoDB" id="3796229at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="200"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="278"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="278"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="296"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAF99765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="346" mass="37902" checksum="263EE6570FB7D903" modified="2016-09-07" version="1">MVGANAHGRDNAATNTKHKHPDHWNGLLSERSMLFYDGGYEWDGTNGFWDDTGIHHDFNDPNDPEAYPPTPRPVGLWLEDDEDVRISEDVSGDLSAAGNQDRSLRRNRAQVQTNSVHTGFLAKFTQEGSKTILIDGNVRKQNLLRDGLFVGHPSRERLLGQVEGMVIGQHMFIDGHNLADSYELCGMEISSALLANGDAVNPGSSAAKPPTMSGDRVKASGTVGNDVHHLGALTEDGEMKSEGAQADDQEADFGRELLFISSPLSDCPSDLSEWEVEDQIKRSHRAEAPRLGTKSESNRTFHESHEDGSKRSIKTKIRRDSVDPGVVFGNPSQEAVHPDLPAAMIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BY60</accession>
    <name>A0A177BY60_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Heat-stable 19 kDa antigen</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CC84DRAFT_1104243</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cerato-platanin family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441562">
        <property type="protein sequence ID" value="OAF99457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029823.1">
        <property type="nucleotide sequence ID" value="XM_018175046.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BY60"/>
    <dbReference type="GeneID" id="28758532"/>
    <dbReference type="InParanoid" id="A0A177BY60"/>
    <dbReference type="OrthoDB" id="4898945at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd22778">
        <property type="entry name" value="DPBB_CEPL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="entry name" value="RlpA-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010829">
        <property type="entry name" value="Cerato-platanin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07249">
        <property type="entry name" value="Cerato-platanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50685">
        <property type="entry name" value="Barwin-like endoglucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008057480" evidence="4">
        <location>
            <begin position="17"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAF99457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="135" mass="14291" checksum="CE917992997AF323" modified="2016-09-07" version="1">MKFSALALGFASLASAITVSYDTGYDDQSRAMTAVSCSDGANGLITKYGWQTQANIKTPYYGGYQGIAGWNSAQCGTCYSLTYKGKTIYVLAIDHTAAGFNINKKGLDALTNNQATQLGRVDAQYAQVALSKCGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BZ51</accession>
    <name>A0A177BZ51_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CC84DRAFT_1169067</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441560">
        <property type="protein sequence ID" value="OAG00251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030616.1">
        <property type="nucleotide sequence ID" value="XM_018179565.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BZ51"/>
    <dbReference type="STRING" id="1460663.A0A177BZ51"/>
    <dbReference type="GeneID" id="28763051"/>
    <dbReference type="InParanoid" id="A0A177BZ51"/>
    <dbReference type="OrthoDB" id="5319341at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF3">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="22"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="59"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="62"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAG00251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="585" mass="66083" checksum="8728241D64387065" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BZ90</accession>
    <name>A0A177BZ90_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_292353</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441559">
        <property type="protein sequence ID" value="OAG00301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030666.1">
        <property type="nucleotide sequence ID" value="XM_018185766.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BZ90"/>
    <dbReference type="GeneID" id="28769252"/>
    <dbReference type="InParanoid" id="A0A177BZ90"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG00301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="207" mass="23109" checksum="26DAB380D1C911B6" modified="2016-09-07" version="1">MKRQRQWWSGRRPLQKGCLGSRWMRCSLLLSTRMSLCMKCGNNSGRQPMVVDHHAHPISPAVSASNHDNTADTLVAESTRPSSSKTGNKVIGSEQNPINVKDEDVKDEEEHAVSMHMVAREKRATPDPSRQREQPVPKTSQPHRKQSPVVDVSKNRSRNPKSRKGSADVAIGSKLNKHVPQGYADSFQAHSLENSILLKKPKQLQTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BZB5</accession>
    <name>A0A177BZB5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1180565</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441559">
        <property type="protein sequence ID" value="OAG00565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030930.1">
        <property type="nucleotide sequence ID" value="XM_018180483.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BZB5"/>
    <dbReference type="GeneID" id="28763969"/>
    <dbReference type="InParanoid" id="A0A177BZB5"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG00565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="154" mass="17279" checksum="193AFEC2D558E6F9" modified="2016-09-07" version="1">MSTTAYIRRGEKQQRQSACQKYKDQAQEDLAGYEKLEKNITDNYNEEIEGGAEASEYEESSIQDHDAEGTAPISVYDSWMTLNPSQSIERLYQHPNPSIYHFAVMSNEGKLTGATIYIYSPPYAEIQAWVVPSSQSSNPNGRRIGTAPLQYGSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BZG7</accession>
    <name>A0A177BZG7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1230799</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441559">
        <property type="protein sequence ID" value="OAG00615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030980.1">
        <property type="nucleotide sequence ID" value="XM_018183706.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BZG7"/>
    <dbReference type="GeneID" id="28767192"/>
    <dbReference type="InParanoid" id="A0A177BZG7"/>
    <dbReference type="OrthoDB" id="3946303at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="329"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="423"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="548"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="330"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="373"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="389"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="435"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="447"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG00615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="608" mass="67941" checksum="8122D964533F7748" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BZM4</accession>
    <name>A0A177BZM4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_383288</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441561">
        <property type="protein sequence ID" value="OAF99799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030165.1">
        <property type="nucleotide sequence ID" value="XM_018185989.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BZM4"/>
    <dbReference type="GeneID" id="28769475"/>
    <dbReference type="InParanoid" id="A0A177BZM4"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAF99799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="81" mass="9164" checksum="6FAE2F03E193E050" modified="2016-09-07" version="1">MPSVHVCSALIRVTWSTESGSVEKVNLIRAWFFMSFKPPKPLRSCTCNNTFTMMKPSHTHSIHKARQDAQGLLIYKQGVLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BZN4</accession>
    <name>A0A177BZN4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Concanavalin A-like lectin/glucanase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_1231458</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the glycosyl hydrolase 12 (cellulase H) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441560">
        <property type="protein sequence ID" value="OAG00052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030417.1">
        <property type="nucleotide sequence ID" value="XM_018183724.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BZN4"/>
    <dbReference type="STRING" id="1460663.A0A177BZN4"/>
    <dbReference type="GeneID" id="28767210"/>
    <dbReference type="InParanoid" id="A0A177BZN4"/>
    <dbReference type="OrthoDB" id="89349at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008810">
        <property type="term" value="F:cellulase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013319">
        <property type="entry name" value="GH11/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002594">
        <property type="entry name" value="GH12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34002">
        <property type="entry name" value="BLR1656 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34002:SF10">
        <property type="entry name" value="PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01670">
        <property type="entry name" value="Glyco_hydro_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0430">Lectin</keyword>
    <keyword evidence="2" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008057492" evidence="3">
        <location>
            <begin position="18"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAG00052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="273" mass="29944" checksum="A43F0CA5465D2D2C" modified="2016-09-07" version="1">MKIFAALFVSSLSSAYANPITYVTDSKIVQRGTPTTRDATSVQENVSLCTQYAYYATNNYEILNNLWGKDSATSGSQCTYFEGTSGSGIKWSSTWTWQGGENNVKSYVYAGRLLTKGNTVAKVKTMQSQINWSYNTTNNVRANVAYDIFTASDPNHVNSSGDYELMIWLGRLGGVWPISQAGAPIATVTIAGYAFDLYFGYNGSMKVYSFVRSGSNDITSFKADIKLFFDYLVKNQQYPASSQNLIVYQIGTEAFTGGPAKFSVSTFSADLTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BZQ4</accession>
    <name>A0A177BZQ4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1222358</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441560">
        <property type="protein sequence ID" value="OAG00028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030393.1">
        <property type="nucleotide sequence ID" value="XM_018183360.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BZQ4"/>
    <dbReference type="STRING" id="1460663.A0A177BZQ4"/>
    <dbReference type="GeneID" id="28766846"/>
    <dbReference type="InParanoid" id="A0A177BZQ4"/>
    <dbReference type="OrthoDB" id="6431331at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37471:SF1">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37471">
        <property type="entry name" value="UNNAMED PRODUCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG00028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="527" mass="60960" checksum="D9E42B05C7A35C1A" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BZV2</accession>
    <name>A0A177BZV2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">5'-nucleotidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CC84DRAFT_1199663</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the 5'-nucleotidase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441560">
        <property type="protein sequence ID" value="OAG00122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030487.1">
        <property type="nucleotide sequence ID" value="XM_018181631.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BZV2"/>
    <dbReference type="STRING" id="1460663.A0A177BZV2"/>
    <dbReference type="GeneID" id="28765117"/>
    <dbReference type="InParanoid" id="A0A177BZV2"/>
    <dbReference type="OrthoDB" id="7722975at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009166">
        <property type="term" value="P:nucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07409">
        <property type="entry name" value="MPP_CD73_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000020">
        <property type="entry name" value="NT5E isoform 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.780.10">
        <property type="entry name" value="5'-Nucleotidase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008334">
        <property type="entry name" value="5'-Nucleotdase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036907">
        <property type="entry name" value="5'-Nucleotdase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006146">
        <property type="entry name" value="5'-Nucleotdase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006179">
        <property type="entry name" value="5_nucleotidase/apyrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11575:SF24">
        <property type="entry name" value="5'-NUCLEOTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11575">
        <property type="entry name" value="5'-NUCLEOTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02872">
        <property type="entry name" value="5_nucleotid_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01607">
        <property type="entry name" value="APYRASEFAMLY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55816">
        <property type="entry name" value="5'-nucleotidase (syn. UDP-sugar hydrolase), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00786">
        <property type="entry name" value="5_NUCLEOTIDASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007948924" evidence="6">
        <location>
            <begin position="24"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="7">
        <location>
            <begin position="48"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="5'-Nucleotidase C-terminal" evidence="8">
        <location>
            <begin position="349"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAG00122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="547" mass="59611" checksum="0ED2AF07017D2930" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2023-06-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C0L6</accession>
    <name>A0A177C0L6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_297603</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441559">
        <property type="protein sequence ID" value="OAG00348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030713.1">
        <property type="nucleotide sequence ID" value="XM_018185781.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C0L6"/>
    <dbReference type="GeneID" id="28769267"/>
    <dbReference type="InParanoid" id="A0A177C0L6"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG00348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="95" mass="10601" checksum="90957A2118A996FD" modified="2016-09-07" version="1">MRDIHHTPHLKIYLHSLWSPDGCPGASSPNIHLPLLYPYTPRHHLLSPSRPRVLGELLPCSSSILTYLCLRLCIASPARSAFISVHLLVVEVLFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C0M0</accession>
    <name>A0A177C0M0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1054094</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441560">
        <property type="protein sequence ID" value="OAG00257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030622.1">
        <property type="nucleotide sequence ID" value="XM_018173520.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C0M0"/>
    <dbReference type="GeneID" id="28757006"/>
    <dbReference type="InParanoid" id="A0A177C0M0"/>
    <dbReference type="OrthoDB" id="3797698at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG00257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="118" mass="13691" checksum="3DA51EDFDCDC5665" modified="2016-09-07" version="1" fragment="single">FEEETILKSFETTGISLFDPEVILRRFKKTTQDDNQGSRESSKKDAQKLRRSLHHISAKVQLLHHENAGLREALAIKTKHKKNVKPLDLQQRQEYHGGAVFWSSSKVRKARVRQSVKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C1A5</accession>
    <name>A0A177C1A5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1221733</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441558">
        <property type="protein sequence ID" value="OAG01206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031571.1">
        <property type="nucleotide sequence ID" value="XM_018183297.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C1A5"/>
    <dbReference type="STRING" id="1460663.A0A177C1A5"/>
    <dbReference type="GeneID" id="28766783"/>
    <dbReference type="InParanoid" id="A0A177C1A5"/>
    <dbReference type="OrthoDB" id="2394218at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42749">
        <property type="entry name" value="CELL SHAPE-DETERMINING PROTEIN MREB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42749:SF1">
        <property type="entry name" value="CELL SHAPE-DETERMINING PROTEIN MREB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG01206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="210" mass="23764" checksum="CA0E96F2E332183A" modified="2016-09-07" version="1">MEFRRSELKSYFDNQLLKLYETIHKQLVRVQEKIPYELVAHMVLSGGFGNAAYNLQIRVVPEPQLVVCNGNVADRMQKLKSGRNVLGWRCCRTSYGTLCKVLYDPNDQLCYGVTTQIDPLYKKPYVMQYIDCFGQPVSSDEPIVQTFKRKGPPATAAQPSPTRMFPTEIICSELDASTLPNVMNAYKSQNPHNRSNICQLTHQPAVLCAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C1D3</accession>
    <name>A0A177C1D3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">N-alpha-acetyltransferase 40</fullName>
            <ecNumber evidence="4">2.3.1.257</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CC84DRAFT_1168685</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>N-terminal L-seryl-[histone H2A] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-seryl-[histone H2A] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50600"/>
            <dbReference type="Rhea" id="RHEA-COMP:12742"/>
            <dbReference type="Rhea" id="RHEA-COMP:12744"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:64738"/>
            <dbReference type="ChEBI" id="CHEBI:83690"/>
            <dbReference type="EC" id="2.3.1.257"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>N-terminal L-seryl-[histone H4] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-seryl-[histone H4] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50596"/>
            <dbReference type="Rhea" id="RHEA-COMP:12740"/>
            <dbReference type="Rhea" id="RHEA-COMP:12743"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:64738"/>
            <dbReference type="ChEBI" id="CHEBI:83690"/>
            <dbReference type="EC" id="2.3.1.257"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the acetyltransferase family. NAA40 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.257" evidence="4"/>
    <dbReference type="EMBL" id="KV441559">
        <property type="protein sequence ID" value="OAG00608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030973.1">
        <property type="nucleotide sequence ID" value="XM_018179456.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C1D3"/>
    <dbReference type="FunCoup" id="A0A177C1D3">
        <property type="interactions" value="109"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177C1D3"/>
    <dbReference type="GeneID" id="28762942"/>
    <dbReference type="InParanoid" id="A0A177C1D3"/>
    <dbReference type="OrthoDB" id="424551at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043998">
        <property type="term" value="F:histone H2A acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010485">
        <property type="term" value="F:histone H4 acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990189">
        <property type="term" value="F:protein N-terminal-serine acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039949">
        <property type="entry name" value="NAA40"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20531">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20531:SF1">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="12">
        <location>
            <begin position="38"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OAG00608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="218" mass="24935" checksum="F02FF3D095DF65F7" modified="2016-09-07" version="1">MTSPERFTREWDDDVLAAVWEHTQKHGQLKDLGGGYKLELRPSTKLSHSDRGACLDIVRHTSMAAYKASRMGWHTPSKRTEMANKDMAYILVRATDGTRDAFGPGIDTNIVGFISFMIDYDDPPNDHRQVVYIFEIHLAERLRGKGLGKWLMFTVEAMAQSVTIKKTMLTVFVSNKAAIQAYKRMGYDKDEASPSDRETRGRIIPSDYWIMSKSWHDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C1Q8</accession>
    <name>A0A177C1Q8_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tachykinin family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1221199</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441557">
        <property type="protein sequence ID" value="OAG01714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032079.1">
        <property type="nucleotide sequence ID" value="XM_018183241.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C1Q8"/>
    <dbReference type="STRING" id="1460663.A0A177C1Q8"/>
    <dbReference type="GeneID" id="28766727"/>
    <dbReference type="InParanoid" id="A0A177C1Q8"/>
    <dbReference type="OrthoDB" id="415825at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540">
        <property type="entry name" value="TRANSCRIPTION FACTOR (ACR-2), PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540:SF5">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG01714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="644" mass="72247" checksum="31F314A8E710222C" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C1W5</accession>
    <name>A0A177C1W5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1221374</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441558">
        <property type="protein sequence ID" value="OAG00808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031173.1">
        <property type="nucleotide sequence ID" value="XM_018183268.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C1W5"/>
    <dbReference type="GeneID" id="28766754"/>
    <dbReference type="InParanoid" id="A0A177C1W5"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG00808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="173" mass="19189" checksum="83E9D0A788F23DB6" modified="2016-09-07" version="1">MDISIPLLQYPIPVTFEGVIAEQEFLFAESCASLSPLKKKKKKKKKKKKKKEKKRIDLAAIKLKKCGPTFDRKCLVEGLGFRGDKRCPYHRRNVMERASARGRIDVDIGLIVVDRLGVRNEPVHTEVAASASGGAQKSGNPTNDDAQEGDDLGMNLDEDLVKCDAQHITVSIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C1W6</accession>
    <name>A0A177C1W6_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ribosomal protein S21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CC84DRAFT_1167649</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bS21 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441557">
        <property type="protein sequence ID" value="OAG01446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031811.1">
        <property type="nucleotide sequence ID" value="XM_018179227.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C1W6"/>
    <dbReference type="STRING" id="1460663.A0A177C1W6"/>
    <dbReference type="GeneID" id="28762713"/>
    <dbReference type="InParanoid" id="A0A177C1W6"/>
    <dbReference type="OrthoDB" id="2501249at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070124">
        <property type="term" value="P:mitochondrial translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052837">
        <property type="entry name" value="Mitoribosomal_bS21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001911">
        <property type="entry name" value="Ribosomal_bS21"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41237">
        <property type="entry name" value="37S RIBOSOMAL PROTEIN MRP21, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41237:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN BS21M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01165">
        <property type="entry name" value="Ribosomal_S21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="34"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="34"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAG01446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="244" mass="27264" checksum="EBD5200A6C332B79" modified="2016-09-07" version="1">MSSRSLGELLLRPTSLLRLSCAQILPRVAPSWTAHRTISTSRTPQAAQPRAKEDLSFDGPAQPDVPASAERTSEAIDSLFSSMPGRAFARQSPAAYTRTSQEEAARKAFGSNFSNARSGSAFQRRTAGLDFDSMSMDGLPLNLPNQAPAVPLEPEKQVYPRLNPAFGRTVDLRPEAGRDLVRGITMLSSLVSRNKIRHDMMKQRFHERPGLKRKRLKSERWRTLFKKGFQEVTGRVSELTRKGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C2K9</accession>
    <name>A0A177C2K9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribonuclease H</fullName>
            <ecNumber evidence="4">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CC84DRAFT_210998</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase H family.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="4"/>
    <dbReference type="EMBL" id="KV441557">
        <property type="protein sequence ID" value="OAG01676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032041.1">
        <property type="nucleotide sequence ID" value="XM_018185595.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C2K9"/>
    <dbReference type="FunCoup" id="A0A177C2K9">
        <property type="interactions" value="240"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177C2K9"/>
    <dbReference type="GeneID" id="28769081"/>
    <dbReference type="InParanoid" id="A0A177C2K9"/>
    <dbReference type="OrthoDB" id="407198at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043137">
        <property type="term" value="P:DNA replication, removal of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.970.10:FF:000002">
        <property type="entry name" value="Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.970.10:FF:000001">
        <property type="entry name" value="Ribonuclease H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.970.10">
        <property type="entry name" value="Ribonuclease H1, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009027">
        <property type="entry name" value="Ribosomal_bL9/RNase_H1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050092">
        <property type="entry name" value="RNase_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011320">
        <property type="entry name" value="RNase_H1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037056">
        <property type="entry name" value="RNase_H1_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10642">
        <property type="entry name" value="RIBONUCLEASE H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10642:SF26">
        <property type="entry name" value="RIBONUCLEASE H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01693">
        <property type="entry name" value="Cauli_VI"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55658">
        <property type="entry name" value="L9 N-domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribonuclease H1 N-terminal" evidence="12">
        <location>
            <begin position="100"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="Ribonuclease H1 N-terminal" evidence="12">
        <location>
            <begin position="157"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="203"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="203"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="271"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OAG01676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="393" mass="44228" checksum="AF8E88D103907B96" modified="2016-09-07" version="1">MRALLKRIPAHRQLLCAALQESLWSAKPRDCSSRHVYHFTRSKPQTVSYLSPLYTRSFSEDARPIVDITFPHDLEKGEDTMAGGSSASSGSKHKRTAPAFYAVKAGFTPGIYQSWDDAKQQTSGFKNPVFKKFTMLTEAEEFMKGESVGAQKSGKSKYYGVQVGHTPGVYMDWPAVLEQVTGFKGAKQKRFDTWEEAQAFVSEAQQGGASSHTTSTPISLNGHVDSTTPSEVESRKSTKKQKQNDGFAVPTATNGDYEPGTGPLPPDAEDGFDRRIKHGRPDGPEIEYKTQEELSLRKFQPTGDFEGVLEVYTDGASKGNGQLGAYAGFGIWFGPNDPRKDKRSRRRRWQSLRQMRRRMGQRWMNRREVVEYRNLWTFLQELGQYGSRGKRVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C2T1</accession>
    <name>A0A177C2T1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Nitroreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_1220459</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the nitroreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441556">
        <property type="protein sequence ID" value="OAG02094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032459.1">
        <property type="nucleotide sequence ID" value="XM_018183172.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C2T1"/>
    <dbReference type="FunCoup" id="A0A177C2T1">
        <property type="interactions" value="13"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177C2T1"/>
    <dbReference type="GeneID" id="28766658"/>
    <dbReference type="InParanoid" id="A0A177C2T1"/>
    <dbReference type="OrthoDB" id="2138173at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02140">
        <property type="entry name" value="Frm2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.109.10:FF:000001">
        <property type="entry name" value="Nitroreductase family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="entry name" value="NADH Oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033877">
        <property type="entry name" value="Frm2/Hbn1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029479">
        <property type="entry name" value="Nitroreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43035">
        <property type="entry name" value="FATTY ACID REPRESSION MUTANT PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43035:SF1">
        <property type="entry name" value="FATTY ACID REPRESSION MUTANT PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00881">
        <property type="entry name" value="Nitroreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="FMN-dependent nitroreductase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitroreductase" evidence="7">
        <location>
            <begin position="11"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAG02094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="205" mass="23462" checksum="C73108B36B6C67E6" modified="2016-09-07" version="1">MAAQKSFLDAVKDRRTIYQLNKEAPKSDKEIVDIVNQIVLHVPSSFNSQSTRVVVLLNQEHEKFWELTKEVLKPQVPEEQYKSGTEPKLNGFKGAYGTILFFEDPQPVEDLRKAFPIYAHHFGDWSEHTSAMHQFAAWTALEAEGFGANLQHYNPIVDQKIQSEWNVPQQWKLRAQLVFGGKAGEAGEKQFKPLEERVFVHGAKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C320</accession>
    <name>A0A177C320_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1220832</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441557">
        <property type="protein sequence ID" value="OAG01309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031674.1">
        <property type="nucleotide sequence ID" value="XM_018183206.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C320"/>
    <dbReference type="GeneID" id="28766692"/>
    <dbReference type="InParanoid" id="A0A177C320"/>
    <dbReference type="OrthoDB" id="341259at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG01309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="128" mass="14237" checksum="6EDC4AEA2DF1E51A" modified="2016-09-07" version="1">MKFLFETQKKELRYLRDMLQSVDTRSAQSSDPPATATNDKNHKATADLHDTDLKTGNRLNADLNDDTVGGAEVSATSPNADGVQISDDVGDDYYVHSGEAPTNYYRSFVKRRPGDPRLGAMWTQRRNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C376</accession>
    <name>A0A177C376_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1154610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441558">
        <property type="protein sequence ID" value="OAG01120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031485.1">
        <property type="nucleotide sequence ID" value="XM_018176900.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C376"/>
    <dbReference type="GeneID" id="28760386"/>
    <dbReference type="InParanoid" id="A0A177C376"/>
    <dbReference type="OrthoDB" id="3786746at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG01120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="135" mass="15186" checksum="EC70D1EB9C14588C" modified="2016-09-07" version="1">MSTSATSPYGLPPSPRATRPELSPINTSFRTTPTSYSDATPSPNEKASAHSYSFTNTRPRRRDSDIFANATIPLSPPPSPPSAYKESPFDGVAPRRRNPFARLFCCLGREERARRRAMWADEFEQVGEKRHWTEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C396</accession>
    <name>A0A177C396_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 25">tRNA-dihydrouridine(47) synthase [NAD(P)(+)]</fullName>
            <ecNumber evidence="4 25">1.3.1.89</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="25">tRNA-dihydrouridine synthase 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="28" type="ORF">CC84DRAFT_1100878</name>
    </gene>
    <organism evidence="28 29">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="28 29" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="28 29">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="19">Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs. Specifically modifies U47 in cytoplasmic tRNAs. Catalyzes the synthesis of dihydrouridine in some mRNAs, thereby affecting their translation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>5,6-dihydrouridine(47) in tRNA + NAD(+) = uridine(47) in tRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53364"/>
            <dbReference type="Rhea" id="RHEA-COMP:13539"/>
            <dbReference type="Rhea" id="RHEA-COMP:13540"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.89"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="20">
            <dbReference type="Rhea" id="RHEA:53366"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>5,6-dihydrouridine(47) in tRNA + NADP(+) = uridine(47) in tRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53360"/>
            <dbReference type="Rhea" id="RHEA-COMP:13539"/>
            <dbReference type="Rhea" id="RHEA-COMP:13540"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.89"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="23">
            <dbReference type="Rhea" id="RHEA:53362"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>a 5,6-dihydrouridine in mRNA + NAD(+) = a uridine in mRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69851"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:17789"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="21">
            <dbReference type="Rhea" id="RHEA:69853"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>a 5,6-dihydrouridine in mRNA + NADP(+) = a uridine in mRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69855"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:17789"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="22">
            <dbReference type="Rhea" id="RHEA:69857"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 25">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="25">Belongs to the dus family. Dus3 subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.89" evidence="4 25"/>
    <dbReference type="EMBL" id="KV441558">
        <property type="protein sequence ID" value="OAG01140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031505.1">
        <property type="nucleotide sequence ID" value="XM_018174886.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C396"/>
    <dbReference type="FunCoup" id="A0A177C396">
        <property type="interactions" value="888"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177C396"/>
    <dbReference type="GeneID" id="28758372"/>
    <dbReference type="InParanoid" id="A0A177C396"/>
    <dbReference type="OrthoDB" id="259935at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106414">
        <property type="term" value="F:mRNA dihydrouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102265">
        <property type="term" value="F:tRNA-dihydrouridine47 synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02801">
        <property type="entry name" value="DUS_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000145">
        <property type="entry name" value="tRNA-dihydrouridine(47) synthase [NAD(P)(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035587">
        <property type="entry name" value="DUS-like_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018517">
        <property type="entry name" value="tRNA_hU_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45846">
        <property type="entry name" value="TRNA-DIHYDROURIDINE(47) SYNTHASE [NAD(P)(+)]-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45846:SF1">
        <property type="entry name" value="TRNA-DIHYDROURIDINE(47) SYNTHASE [NAD(P)(+)]-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01207">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25585">
        <property type="entry name" value="zf-CCCH_DUS3L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01136">
        <property type="entry name" value="UPF0034"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 25" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8 25" id="KW-0288">FMN</keyword>
    <keyword evidence="11 24 25" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="17 25" id="KW-0520">NAD</keyword>
    <keyword evidence="15 25" id="KW-0521">NADP</keyword>
    <keyword evidence="18" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16 25" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="29" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0677">Repeat</keyword>
    <keyword evidence="10 25" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="14 24 25" id="KW-0862">Zinc</keyword>
    <keyword evidence="13 24 25" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="27">
        <location>
            <begin position="110"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="24">
        <location>
            <begin position="110"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="26">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="26">
        <location>
            <begin position="256"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="26">
        <location>
            <begin position="50"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="26">
        <location>
            <begin position="76"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="26">
        <location>
            <begin position="87"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="26">
        <location>
            <begin position="256"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00045934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00048266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00048342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00049447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00049513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="RuleBase" id="RU291113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="EMBL" id="OAG01140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="716" mass="80980" checksum="BBD3ED614CD7F013" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C3G5</accession>
    <name>A0A177C3G5_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL22</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">60S ribosomal protein L17</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CC84DRAFT_1262436</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the universal ribosomal protein uL22 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441557">
        <property type="protein sequence ID" value="OAG01328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031693.1">
        <property type="nucleotide sequence ID" value="XM_018185153.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C3G5"/>
    <dbReference type="FunCoup" id="A0A177C3G5">
        <property type="interactions" value="963"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177C3G5"/>
    <dbReference type="GeneID" id="28768639"/>
    <dbReference type="InParanoid" id="A0A177C3G5"/>
    <dbReference type="OrthoDB" id="10254664at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00336">
        <property type="entry name" value="Ribosomal_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.470.10:FF:000010">
        <property type="entry name" value="60S ribosomal protein L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.10">
        <property type="entry name" value="Ribosomal protein L22/L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001063">
        <property type="entry name" value="Ribosomal_uL22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018260">
        <property type="entry name" value="Ribosomal_uL22_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005721">
        <property type="entry name" value="Ribosomal_uL22_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036394">
        <property type="entry name" value="Ribosomal_uL22_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01038">
        <property type="entry name" value="uL22_arch_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11593">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11593:SF10">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00237">
        <property type="entry name" value="Ribosomal_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54843">
        <property type="entry name" value="Ribosomal protein L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00464">
        <property type="entry name" value="RIBOSOMAL_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6 7" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAG01328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="212" mass="23601" checksum="6AD09E12F5A0EC0A" modified="2016-09-07" version="1">MKLTEKPPEIYWVNALLSAVAVGYPPHITMVRYAATSIDNAKSARARGSYLRTSFKNTRETAQAINGWRLERALTFLGNVIEHKEAVPMRRYAGSTGRTAQGKAFGVSKARWPVKSAEFVLGLLKNAEANADTKGLDTSNLVVKHIQVNQAPKQRRRTYRAHGRINPYMSNPCHIELILTEANEAVQKAEPIAHRLNSRQQGRATRRAITAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C3J0</accession>
    <name>A0A177C3J0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_1190365</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441558">
        <property type="protein sequence ID" value="OAG01230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031595.1">
        <property type="nucleotide sequence ID" value="XM_018181112.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C3J0"/>
    <dbReference type="GeneID" id="28764598"/>
    <dbReference type="InParanoid" id="A0A177C3J0"/>
    <dbReference type="OrthoDB" id="2213137at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF287">
        <property type="entry name" value="MFS MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="55"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="124"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="151"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="224"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="256"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAG01230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="358" mass="38585" checksum="44E388BF853631A7" modified="2016-09-07" version="1">MFLRPPAVDHAKDGWLFPASAVMLEALLWGFPSVFGVFQDYYITHPPFAGSQSTAVIGTCAMATMYLGIACGVCVMCLAQGLGSFSTSAPQLITSRGIVYTVGGGFAWTLILQYMPEWFDKMLSLAYGIVLAGSALAGVVLPPLVQWLLYAYGYQTTLRVCAIFMFLLAVPMLRTAGIFRSRNVSQNFLIAQAGEFIEAQGYFIPFVYLPSHVRLLGANHFRRSLTVILLNGAACVACIVMGALMDRYHFSIGVHISSLGTIMSVFCFWVFSVLYGLLGCAWLCTRSGVVTEMQKQGRVKDPGLVFATLAAGQGTGSIASGPLSELLIRGRYGAADAFTSVTAFVGNCSVVARRASWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2023-06-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C3Y7</accession>
    <name>A0A177C3Y7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_200463</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441557">
        <property type="protein sequence ID" value="OAG01508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031873.1">
        <property type="nucleotide sequence ID" value="XM_018185561.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C3Y7"/>
    <dbReference type="GeneID" id="28769047"/>
    <dbReference type="InParanoid" id="A0A177C3Y7"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG01508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="100" mass="11716" checksum="0A192563E6FF6751" modified="2016-09-07" version="1">MGWECRRGARRLKQRRLWVCFKGRDLPHRETPFFSGKQATSSYINVRRRRCVPVFLLFVQSRSLGLGVPGCVPAFSVYPLNLHYDPRPPQPLYPARVWKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C408</accession>
    <name>A0A177C408_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_974475</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441556">
        <property type="protein sequence ID" value="OAG01901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032266.1">
        <property type="nucleotide sequence ID" value="XM_018188017.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C408"/>
    <dbReference type="STRING" id="1460663.A0A177C408"/>
    <dbReference type="GeneID" id="28771503"/>
    <dbReference type="InParanoid" id="A0A177C408"/>
    <dbReference type="OrthoDB" id="5152799at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG01901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="187" mass="20936" checksum="E65834F75C399801" modified="2016-09-07" version="1">MVHLNRVATDKEIKAAKGLIDGMKKFTLAVEDEPDDYTATVYGSKYAAEDLPRHEMPVRTSNTLHGHCLLTAPGPRDAAPGVGSFLLRRRSCPCSPHKRVPHDQGRPHARWHPDAQPGLVRHHLHGKCLSCGSVSFSTSGKRGPRQWNTNILTIAFCGLAVFQEWSQSSRRWLARCTHLRNLMLCLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C4L7</accession>
    <name>A0A177C4L7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CC84DRAFT_1166515</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG02684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033049.1">
        <property type="nucleotide sequence ID" value="XM_018178978.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C4L7"/>
    <dbReference type="STRING" id="1460663.A0A177C4L7"/>
    <dbReference type="GeneID" id="28762464"/>
    <dbReference type="InParanoid" id="A0A177C4L7"/>
    <dbReference type="OrthoDB" id="303614at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009927">
        <property type="term" value="F:histidine phosphotransfer kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.130:FF:000023">
        <property type="entry name" value="Sensor histidine kinase/response regulator, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.40:FF:000083">
        <property type="entry name" value="Sensor histidine kinase/response regulator, putative (AFU_orthologue AFUA_4G00660)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43047:SF72">
        <property type="entry name" value="OSMOSENSING HISTIDINE PROTEIN KINASE SLN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43047">
        <property type="entry name" value="TWO-COMPONENT HISTIDINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55781">
        <property type="entry name" value="GAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase" evidence="8">
        <location>
            <begin position="555"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="9">
        <location>
            <begin position="1070"/>
            <end position="1197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="234"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="279"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="335"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="440"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="674"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1040"/>
            <end position="1061"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="243"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="345"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="442"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="679"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="6">
        <location>
            <position position="1128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAG02684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="1197" mass="132074" checksum="25F3F4E333D3E678" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C551</accession>
    <name>A0A177C551_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4484 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1125819</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441556">
        <property type="protein sequence ID" value="OAG01898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032263.1">
        <property type="nucleotide sequence ID" value="XM_018175730.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C551"/>
    <dbReference type="FunCoup" id="A0A177C551">
        <property type="interactions" value="26"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177C551"/>
    <dbReference type="GeneID" id="28759216"/>
    <dbReference type="InParanoid" id="A0A177C551"/>
    <dbReference type="OrthoDB" id="2152680at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028115">
        <property type="entry name" value="DUF4484"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018626">
        <property type="entry name" value="LCHN/Anr2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053056">
        <property type="entry name" value="Lipid_Metab_Assoc_Protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28153:SF1">
        <property type="entry name" value="DUF4484 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28153">
        <property type="entry name" value="PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09804">
        <property type="entry name" value="DENND11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14831">
        <property type="entry name" value="DUF4484"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4484" evidence="2">
        <location>
            <begin position="414"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG01898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="551" mass="60821" checksum="497BC1822975E8DE" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C562</accession>
    <name>A0A177C562_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">ATP-dependent RNA helicase DHH1</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">ATP-dependent RNA helicase dhh1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">CC84DRAFT_897986</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">P-body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the DEAD box helicase family. DDX6/DHH1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG02576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032941.1">
        <property type="nucleotide sequence ID" value="XM_018187836.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C562"/>
    <dbReference type="FunCoup" id="A0A177C562">
        <property type="interactions" value="1303"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177C562"/>
    <dbReference type="GeneID" id="28771322"/>
    <dbReference type="InParanoid" id="A0A177C562"/>
    <dbReference type="OrthoDB" id="10265785at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098562">
        <property type="term" value="C:cytoplasmic side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042149">
        <property type="term" value="P:cellular response to glucose starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006995">
        <property type="term" value="P:cellular response to nitrogen starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000290">
        <property type="term" value="P:deadenylation-dependent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036267">
        <property type="term" value="P:invasive filamentous growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045900">
        <property type="term" value="P:negative regulation of translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033962">
        <property type="term" value="P:P-body assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045727">
        <property type="term" value="P:positive regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007124">
        <property type="term" value="P:pseudohyphal growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010603">
        <property type="term" value="P:regulation of cytoplasmic mRNA processing body assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000749">
        <property type="term" value="P:response to pheromone triggering conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034063">
        <property type="term" value="P:stress granule assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd17940">
        <property type="entry name" value="DEADc_DDX6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000114">
        <property type="entry name" value="ATP-dependent RNA helicase DDX6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000364">
        <property type="entry name" value="ATP-dependent RNA helicase DDX6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47960">
        <property type="entry name" value="DEAD-BOX ATP-DEPENDENT RNA HELICASE 50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 17" id="KW-0347">Helicase</keyword>
    <keyword evidence="6 17" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="5 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="10" id="KW-0810">Translation regulation</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="21">
        <location>
            <begin position="49"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="19">
        <location>
            <begin position="80"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="20">
        <location>
            <begin position="260"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="429"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="16">
        <location>
            <begin position="49"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="433"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="453"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="18">
        <location>
            <begin position="463"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="481"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00038316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00040210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00040448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="OAG02576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="515" mass="57469" checksum="DD13051A19AB5AE6" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C5C4</accession>
    <name>A0A177C5C4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4211 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_938387</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG02954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033319.1">
        <property type="nucleotide sequence ID" value="XM_018187921.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C5C4"/>
    <dbReference type="STRING" id="1460663.A0A177C5C4"/>
    <dbReference type="GeneID" id="28771407"/>
    <dbReference type="InParanoid" id="A0A177C5C4"/>
    <dbReference type="OrthoDB" id="21499at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025451">
        <property type="entry name" value="DUF4211"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14689:SF0">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 82"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14689">
        <property type="entry name" value="PHORBOL-ESTER_DAG-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13926">
        <property type="entry name" value="DUF4211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4211" evidence="2">
        <location>
            <begin position="420"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="561"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="76"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="259"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="296"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="322"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="338"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="372"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="412"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="561"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="587"/>
            <end position="602"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG02954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="706" mass="78687" checksum="465CB4008FD2BA08" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C5P2</accession>
    <name>A0A177C5P2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1064174</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG03074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033439.1">
        <property type="nucleotide sequence ID" value="XM_018173623.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C5P2"/>
    <dbReference type="STRING" id="1460663.A0A177C5P2"/>
    <dbReference type="GeneID" id="28757109"/>
    <dbReference type="InParanoid" id="A0A177C5P2"/>
    <dbReference type="OrthoDB" id="5376804at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021514">
        <property type="entry name" value="DUF3176"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35394">
        <property type="entry name" value="DUF3176 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35394:SF5">
        <property type="entry name" value="DUF3176 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11374">
        <property type="entry name" value="DUF3176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG03074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="92" mass="10363" checksum="C7D50C7B92CF572C" modified="2016-09-07" version="1" fragment="single">SWTAETHILVFSVLTFAGLVATLMAHQNKPNPKWPQLVTINSIVSLFSLPMRAVISLVLAEGISQSKWQWHRQSRRLNGMVHFDAAKRGPWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C5Q2</accession>
    <name>A0A177C5Q2_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CC84DRAFT_1189503</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441556">
        <property type="protein sequence ID" value="OAG02212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032577.1">
        <property type="nucleotide sequence ID" value="XM_018181060.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C5Q2"/>
    <dbReference type="STRING" id="1460663.A0A177C5Q2"/>
    <dbReference type="GeneID" id="28764546"/>
    <dbReference type="InParanoid" id="A0A177C5Q2"/>
    <dbReference type="OrthoDB" id="4898680at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF40">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="31"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="68"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="70"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAG02212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="754" mass="85157" checksum="44F7FBA18B821B89" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C5W2</accession>
    <name>A0A177C5W2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1178473</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG02905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033270.1">
        <property type="nucleotide sequence ID" value="XM_018180345.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C5W2"/>
    <dbReference type="STRING" id="1460663.A0A177C5W2"/>
    <dbReference type="GeneID" id="28763831"/>
    <dbReference type="InParanoid" id="A0A177C5W2"/>
    <dbReference type="OrthoDB" id="3791063at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="332"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="498"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="570"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="264"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="338"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="382"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="409"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="422"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="447"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="504"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG02905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="714" mass="80803" checksum="B001E6F47D5E5217" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C5Y9</accession>
    <name>A0A177C5Y9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DUF862-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CC84DRAFT_1124969</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DeSI family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG02935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033300.1">
        <property type="nucleotide sequence ID" value="XM_018175705.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C5Y9"/>
    <dbReference type="STRING" id="1460663.A0A177C5Y9"/>
    <dbReference type="GeneID" id="28759191"/>
    <dbReference type="InParanoid" id="A0A177C5Y9"/>
    <dbReference type="OrthoDB" id="21221at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070646">
        <property type="term" value="P:protein modification by small protein removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02947">
        <property type="entry name" value="TRX_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1720.30">
        <property type="entry name" value="PPPDE domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008580">
        <property type="entry name" value="PPPDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042266">
        <property type="entry name" value="PPPDE_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013535">
        <property type="entry name" value="PUL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12378">
        <property type="entry name" value="DESUMOYLATING ISOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12378:SF7">
        <property type="entry name" value="DESUMOYLATING ISOPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05903">
        <property type="entry name" value="Peptidase_C97"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08324">
        <property type="entry name" value="PUL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01179">
        <property type="entry name" value="DUF862"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51858">
        <property type="entry name" value="PPPDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51396">
        <property type="entry name" value="PUL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPPDE" evidence="6">
        <location>
            <begin position="1"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="4">
        <location>
            <begin position="167"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="PUL" evidence="5">
        <location>
            <begin position="300"/>
            <end position="606"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAG02935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="606" mass="66263" checksum="EC052300C146BE1E" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C6I9</accession>
    <name>A0A177C6I9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Checkpoint forkhead associated with RING domains-containing protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CC84DRAFT_1098858</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the DMA1 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="3"/>
    <dbReference type="EMBL" id="KV441556">
        <property type="protein sequence ID" value="OAG02388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032753.1">
        <property type="nucleotide sequence ID" value="XM_018174791.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C6I9"/>
    <dbReference type="FunCoup" id="A0A177C6I9">
        <property type="interactions" value="130"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177C6I9"/>
    <dbReference type="GeneID" id="28758277"/>
    <dbReference type="InParanoid" id="A0A177C6I9"/>
    <dbReference type="OrthoDB" id="687730at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000132">
        <property type="term" value="P:establishment of mitotic spindle orientation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031578">
        <property type="term" value="P:mitotic spindle orientation checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051865">
        <property type="term" value="P:protein autoubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097271">
        <property type="term" value="P:protein localization to bud neck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090337">
        <property type="term" value="P:regulation of formin-nucleated actin cable assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000921">
        <property type="term" value="P:septin ring assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000426">
        <property type="entry name" value="DMA1p Ubiquitin-protein ligase (E3)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.20:FF:000030">
        <property type="entry name" value="FHA domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15067:SF7">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE DMA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15067">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17123">
        <property type="entry name" value="zf-RING_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FHA" evidence="15">
        <location>
            <begin position="81"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="16">
        <location>
            <begin position="224"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="288"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="351"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="389"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="25"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="391"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00061209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00080465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="OAG02388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="441" mass="47859" checksum="86A91BEF6A05D4B7" modified="2016-09-07" version="1">MTRTRAETAAPQLTVRNHSGPIPTTPTMASSQADQPTPSEAPAMKDLPSIRFIMHQDPRAARPSLSFSTINRTLPDESAVIKVGRYSERDVLPDVPKDQPSAAAVGFKSKVVSRKHCELWCKNGEWWIKDVKSSSGTFLNHIRLSQPNQESKPFKLKDGDIIQLGIDFRGGEEMIFRCVKIRIECNRGWQQALNAFNKQTHQRLRNLGKAKKDGDNASTHTSECSICLMSIAPCQSLFVAPCSHVWHYKCIRPILNGPTYPNFLCPNCRAVTDLEADVDDPVDFDEWEEEPAQENGEVKTNGASSQEDRHVTPKASTNALNALAGSHISFGDLEAAISNISISDSVTRVTSESTVDPSTPQRSPAPFASSSVTQPVAINVIAANESVGLTPLQNRSSNSSDGLSPNGAPEGPMTPRNDAGPFVLDGSGSTGRAAGQRFRDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C6S7</accession>
    <name>A0A177C6S7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Transcriptional activator spt7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CC84DRAFT_1096904</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG02572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032937.1">
        <property type="nucleotide sequence ID" value="XM_018174689.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C6S7"/>
    <dbReference type="FunCoup" id="A0A177C6S7">
        <property type="interactions" value="417"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177C6S7"/>
    <dbReference type="GeneID" id="28758175"/>
    <dbReference type="InParanoid" id="A0A177C6S7"/>
    <dbReference type="OrthoDB" id="21449at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046695">
        <property type="term" value="C:SLIK (SAGA-like) complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05510">
        <property type="entry name" value="Bromo_SPT7_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22927">
        <property type="entry name" value="HFD_SPT7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000072">
        <property type="entry name" value="Transcriptional activator spt7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018359">
        <property type="entry name" value="Bromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006565">
        <property type="entry name" value="BTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037782">
        <property type="entry name" value="Spt7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47343">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR SPT7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47343:SF1">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR SPT7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07524">
        <property type="entry name" value="Bromo_TP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00633">
        <property type="entry name" value="BROMODOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Bromo" evidence="8">
        <location>
            <begin position="328"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="97"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="174"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="232"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="427"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="538"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1020"/>
            <end position="1130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="25"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="119"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="182"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="251"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="427"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="439"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="470"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1064"/>
            <end position="1074"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAG02572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="1130" mass="125067" checksum="2B6B5D1E16C8CDAC" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C7C6</accession>
    <name>A0A177C7C6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_862419</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG03654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034019.1">
        <property type="nucleotide sequence ID" value="XM_018187675.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C7C6"/>
    <dbReference type="GeneID" id="28771161"/>
    <dbReference type="InParanoid" id="A0A177C7C6"/>
    <dbReference type="OrthoDB" id="3945200at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG03654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="542" mass="62507" checksum="D970219C31CC1DD7" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C7G8</accession>
    <name>A0A177C7G8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_850696</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG03495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033860.1">
        <property type="nucleotide sequence ID" value="XM_018187627.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C7G8"/>
    <dbReference type="STRING" id="1460663.A0A177C7G8"/>
    <dbReference type="GeneID" id="28771113"/>
    <dbReference type="InParanoid" id="A0A177C7G8"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF8">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="2">
        <location>
            <begin position="99"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG03495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="358" mass="40192" checksum="39DB03EC035C2719" modified="2016-09-07" version="1">MAYNFLRTKLSLLPHIFQPTRDAIFSFLPFRYRWRLLALQPLNLLSLLITSPSWLFDNCSSVLYVPTRSGPKRCLVYQPPSTGQEQERQGRKPRPLHIDIHGGAWIGGFPEHTARWCASLAVRTGAVVISISYRFAPLHTYPAAHDDVDDVVRYLLNHAAAVGADASLLTLSGSSAGGNLALGVAQMLHSQAASMSAAGERGEVARGYVGFYPVLDLRLRPEEKHKPPKFPNTDPLAWMTPLYDSYAEPTRKRDGDDARINVVVSEKETLPANMFFVVAGIDILACEQLAFVERVRGELDKEGGSEERCVEARVWEEGFHGWLELPKWILEKERMEAYGSAVEFIQRVHRKHSFTFST</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2023-06-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C7H0</accession>
    <name>A0A177C7H0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_910815</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG02718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033083.1">
        <property type="nucleotide sequence ID" value="XM_018187870.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C7H0"/>
    <dbReference type="GeneID" id="28771356"/>
    <dbReference type="InParanoid" id="A0A177C7H0"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG02718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="181" mass="20106" checksum="308F7BCB614D91AF" modified="2016-09-07" version="1">MGISDAILFLAMCSHDIEPTLHDGLIKGGGSSIRCCKMLDPCLSGTRLLPSVRSSPLSSAKYNAHYPQGRRTISAQQLVGPLVRRQSLSHKAHFDARCRDPSVVLARLWLRALSFLRLISWCCRRCSNDLHHNRKLAPSTLEAPLDRVRAGVPKGQIHLRTGVDLETISRHEHDKETFPAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C7I8</accession>
    <name>A0A177C7I8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acyl-CoA N-acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1166541</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG02717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033082.1">
        <property type="nucleotide sequence ID" value="XM_018178986.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C7I8"/>
    <dbReference type="STRING" id="1460663.A0A177C7I8"/>
    <dbReference type="GeneID" id="28762472"/>
    <dbReference type="InParanoid" id="A0A177C7I8"/>
    <dbReference type="OrthoDB" id="410198at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052523">
        <property type="entry name" value="Trichothecene_AcTrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791">
        <property type="entry name" value="GNAT FAMILY ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791:SF5">
        <property type="entry name" value="HYPOTHETICAL ACETYLTRANSFERASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="68"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG02717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="237" mass="27710" checksum="6B29B8BF40C75480" modified="2016-09-07" version="1">MSFKLSDVDLEADFEELMAVMWAAHEEPVQPFFRLFCPIVNGDRQASLKESTERMLEWDRHDPQARWLKVQDVSTGRIAGAAWYKIYKEDPFAHPEEEAVEWYPDDTSRDFVSQAIRQMDRPREEKATRPQVFLNILFTHPGYRRKGIGAMLVQWGIDAAKELGVEFWLNATPVGKPLYEKLGFEVVERNPLVPKTERPDATWNATAREFSDIVFWTMWLPKVGTFETNKTKRPWET</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C7X2</accession>
    <name>A0A177C7X2_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">MFS general substrate transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CC84DRAFT_1151676</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG03231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033596.1">
        <property type="nucleotide sequence ID" value="XM_018176759.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C7X2"/>
    <dbReference type="GeneID" id="28760245"/>
    <dbReference type="InParanoid" id="A0A177C7X2"/>
    <dbReference type="OrthoDB" id="196103at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051617">
        <property type="entry name" value="UNC-93-like_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23294">
        <property type="entry name" value="ET TRANSLATION PRODUCT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23294:SF59">
        <property type="entry name" value="UNC93-LIKE PROTEIN C922.05C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="112"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="234"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="266"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="299"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="340"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="403"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="464"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAG03231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="484" mass="53144" checksum="F2F11DE1EA0AD2D1" modified="2016-09-07" version="1">MTLKFFGREIRYHSPWVQNIISGIGVGASAGIYVALNLLGAGGGRPDSAHVVQVVNATLCSVWFFSSSFGGSILNKLGPGITMCLGVQTYAIYVGSLWYYDEIGKTGYPYAAGPIIGIGAGMVFITAGYIATAYPEEKDKGAYATMLMNMQGLGSVIGGIIPVIINRNKNTAAGVPRPVYISFIIIMIVGGLITLLLKRPQKLRRDDGSTVAVHPARGAWEELRSNLLIFSDPILLMMLPAFFPAECFLVYSGSVNAYLNGLRARSLLSFVAVCLQIPAGWALQWILDRPYWGRRKRGLIGLTVVAVPLLAAWVWEMIRVRNYDRNVTVTDPTDWDEPRFGWIFVLFMLNWVFSQLWHNIVYYWIGAITNSPQKLTHYVGVFRGVLGAGEAVCFGLDSIKIPFIAEAGGVLLFYVLGICSFYYLGIYHIKDTNYDHREEGAVIPNHVLEGKGLTEGQDVAQIRRNSVSEDSSEKEKTKVGGGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C8D1</accession>
    <name>A0A177C8D1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CRAL/TRIO domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1166740</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG02960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033325.1">
        <property type="nucleotide sequence ID" value="XM_018179040.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C8D1"/>
    <dbReference type="FunCoup" id="A0A177C8D1">
        <property type="interactions" value="147"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177C8D1"/>
    <dbReference type="GeneID" id="28762526"/>
    <dbReference type="InParanoid" id="A0A177C8D1"/>
    <dbReference type="OrthoDB" id="75724at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008526">
        <property type="term" value="F:phosphatidylinositol transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.525.10:FF:000013">
        <property type="entry name" value="Phosphatidylinositol transfer protein PDR16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011074">
        <property type="entry name" value="CRAL/TRIO_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052578">
        <property type="entry name" value="PI_Transfer_CRAL-TRIO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45824">
        <property type="entry name" value="GH16843P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45824:SF29">
        <property type="entry name" value="GH16843P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03765">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01100">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="2">
        <location>
            <begin position="106"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="301"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="306"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG02960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="328" mass="36663" checksum="0A041AECCBD674E8" modified="2016-09-07" version="1">MSAIGPFPHPAEGKKPAAPPALTADQQKKYDELLATVKAWTTLPKASAKGAEEEALADPERMWLTRECLLRYLRATKWNLPNATQRLRDTVIWRREYGTDSFTADYISDENATGKQVALGYDNEGRPCLYLLPNKQNTKNSPKQVEHLVYMLERTLDISPPGQETLALLIDFRNSSAGSQPSIGTGRQVLSILQNHYPERLGRALITHLPWYVTTFLKLISPFIDPVTKTKMRYNEPLTDHIPASQLMKNAGGEVDFEYDHSVYWPALAKLAEERRRERTERWEKAGKVVGESEIYLWGGEEGSVATAPTPTATAEAPQPTAEATVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C8H5</accession>
    <name>A0A177C8H5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_957890</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG03078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033443.1">
        <property type="nucleotide sequence ID" value="XM_018187949.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C8H5"/>
    <dbReference type="GeneID" id="28771435"/>
    <dbReference type="InParanoid" id="A0A177C8H5"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG03078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="95" mass="11258" checksum="BCE5CF10B521162B" modified="2016-09-07" version="1">MWTWFRGFLQSQRIFMAYPIRLYGTIRNRALPTNCTCDLFSIIINCNAQTLKAKPFDRYVNAQWHCCQSWLSWVGRTRLTSNYVGHTSTLYVCDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C8J5</accession>
    <name>A0A177C8J5_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">TPR-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_961683</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG03182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033547.1">
        <property type="nucleotide sequence ID" value="XM_018187967.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C8J5"/>
    <dbReference type="STRING" id="1460663.A0A177C8J5"/>
    <dbReference type="GeneID" id="28771453"/>
    <dbReference type="InParanoid" id="A0A177C8J5"/>
    <dbReference type="OrthoDB" id="5308957at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG03182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="482" mass="54388" checksum="5282B07DC5F028B9" modified="2016-09-07" version="1">MVRRALLRKERSKETQFEYGGQKWTLEQALSRASRSKKPIEELANTPEGMVVTTPDNPNDAVPPGNHDDDDEEEFPRSPSVTAIGSDTLPAARGLPLSYNGKTRQDLADILKVARASAQQKDAAKAEQAYIDVFRGLEHLLSPTAVDTVKIGYEIASFYWEQGRKADADGMLETMSATHIKELGMHNRSTQQHILHVVEMLNSWKRGEDALVMLQHARDIEEIERDARPRRRNRAQNMATSSLSVDEKLQSLYTEVDSAVNSTPIDEGLVNARIFMGTNHPTIEVLLKAIERQCLDGPSGMVAQGLRARAELLKHYISKGGRLSAADKHAFETAGDRLKIFWRRTRWDKKQFQSHEVIEASLELAAGVLRGKLVQHARWMFGEIEKKATDVFGADDERTIWTLINIGIIYQTYRTWEEARRWFETALAASLAAWGTSDGVTRALENARDNRHFAYLNDEGRPFETIFGVCGITIRPTRLHLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C8M6</accession>
    <name>A0A177C8M6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1166949</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG03212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033577.1">
        <property type="nucleotide sequence ID" value="XM_018179088.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C8M6"/>
    <dbReference type="STRING" id="1460663.A0A177C8M6"/>
    <dbReference type="GeneID" id="28762574"/>
    <dbReference type="InParanoid" id="A0A177C8M6"/>
    <dbReference type="OrthoDB" id="3509362at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08276">
        <property type="entry name" value="MDR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052711">
        <property type="entry name" value="Zinc_ADH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45033">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45033:SF1">
        <property type="entry name" value="OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="1">
        <location>
            <begin position="5"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG03212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="298" mass="31467" checksum="7FC179C9DC93F989" modified="2016-09-07" version="1">MLREGGYPIPVNEREIEGSCCAAEVVALGSSVTKFSIGERVAPTVNLNFLSGEERDADVCALGGDTAGVLREWAVFDEQHLVKLPGHVSWEEAATITGVGITAWVSLNGLEHVPEGATALLQGTGGVSIMSLLVCLAAGIRPIITSSSDAKLARLAKLSPEIKTINYKTTPDVAAEVLLLTAGKGVDYVLNNAGLSSIPSDLRMLRRYGGRIALIGFLEGFEAGWDASLLMGLIEKAASIKGILAGSRADLEAVSRFLEEKKVDLGPLVDRVFAFGESEKAFAYLEGGSHVGKVVIRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C925</accession>
    <name>A0A177C925_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_1166257</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the Nudix hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG04153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034518.1">
        <property type="nucleotide sequence ID" value="XM_018178911.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C925"/>
    <dbReference type="STRING" id="1460663.A0A177C925"/>
    <dbReference type="GeneID" id="28762397"/>
    <dbReference type="InParanoid" id="A0A177C925"/>
    <dbReference type="OrthoDB" id="447842at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035539">
        <property type="term" value="F:8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006203">
        <property type="term" value="P:dGTP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04678">
        <property type="entry name" value="NUDIX_MTH2_Nudt15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000060">
        <property type="entry name" value="Nudix hydrolase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020476">
        <property type="entry name" value="Nudix_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16099">
        <property type="entry name" value="8-OXO-DGTP DIPHOSPHATES NUDT15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16099:SF5">
        <property type="entry name" value="NUCLEOTIDE TRIPHOSPHATE DIPHOSPHATASE NUDT15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00502">
        <property type="entry name" value="NUDIXFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="3">
        <location>
            <begin position="6"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAG04153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="159" mass="17410" checksum="73926962CD04F4F6" modified="2016-09-07" version="1">MAEAQRPKIGVGVVIHNGAGNIVMGERAGSHGAGTMQCPGGHLEYGESFAECAKREVLEETGLEVGNVKFLVATNDVFGEGKHYVTVFVTCTIVGENTVPQPMEPEKCARWDWIPWAQMWAWAKEQAEAEAGGKSVNKQMFLPLVNLYREYPGMEHCLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C9S0</accession>
    <name>A0A177C9S0_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peroxin 26</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1196658</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG04494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034859.1">
        <property type="nucleotide sequence ID" value="XM_018181479.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C9S0"/>
    <dbReference type="STRING" id="1460663.A0A177C9S0"/>
    <dbReference type="GeneID" id="28764965"/>
    <dbReference type="InParanoid" id="A0A177C9S0"/>
    <dbReference type="OrthoDB" id="3981028at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="379"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="263"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="263"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="282"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="327"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG04494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="428" mass="48295" checksum="36CC5A247E28F3E1" modified="2016-09-07" version="1">MYGDLGSSRNLGASVSSLSSSRQHSQHIAKAYRQAAQLFLTRRLPEALSTIEPIITPPAQDDVNGSPDGDLAGYAPIATASRGTRVKVWSFYLTFLNAVVELGAEEGKLAFGSTRWKQLVSKCRDGSVWDDVARDGYAGVEGDVDAEVVVNLATLLLTHSPSQRLNQHKLETYLSASANPVFDISSHMTSSAYLQRRPSQQNNGTDTPRDLNTRLKLLELYTLHVLPRNDEWDYAREFISMSEVLDDERKEAFLLALHSLKEEKEDAEKREERLRQQQQEQLEQRRRETEARRLEQSRAEDERRKREEENRRQPRGSDEVFRGKGNAPRQAASTSSRASRPAKKAVTPPPGLYHRATALLSSMHAMITNTAHSMTANPMAFFRTLLFLLAFAVAFGRRDLRERIMRVLRNGLDKVRRTVGMGVKVSYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C9Z3</accession>
    <name>A0A177C9Z3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_860009</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG03577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033942.1">
        <property type="nucleotide sequence ID" value="XM_018187654.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C9Z3"/>
    <dbReference type="GeneID" id="28771140"/>
    <dbReference type="InParanoid" id="A0A177C9Z3"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG03577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="157" mass="17866" checksum="6923805618BC677A" modified="2016-09-07" version="1">MLGQPTYLLCFGLCYVSTRRLLTYVPSLPRWLRLTCLSAMGLRETRVHGRPGLCWAGILLWRLFSLTSRWLPLASLFFRDLAMLFLFFFSVSCRRRGISAVALLSGADGFVVLRMGRDSYTCAALLGRFGARDLGRRVLVVDLCQLRWFSLRESACT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CA52</accession>
    <name>A0A177CA52_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Copper homeostasis protein cutC homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1165909</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CutC family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG03722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034087.1">
        <property type="nucleotide sequence ID" value="XM_018178826.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CA52"/>
    <dbReference type="STRING" id="1460663.A0A177CA52"/>
    <dbReference type="GeneID" id="28762312"/>
    <dbReference type="InParanoid" id="A0A177CA52"/>
    <dbReference type="OrthoDB" id="7392499at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.380">
        <property type="entry name" value="Copper homeostasis (CutC) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00795">
        <property type="entry name" value="CutC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005627">
        <property type="entry name" value="CutC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036822">
        <property type="entry name" value="CutC-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12598">
        <property type="entry name" value="COPPER HOMEOSTASIS PROTEIN CUTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12598:SF0">
        <property type="entry name" value="COPPER HOMEOSTASIS PROTEIN CUTC HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03932">
        <property type="entry name" value="CutC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110395">
        <property type="entry name" value="CutC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG03722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="221" mass="23857" checksum="21A500D4DBBD3F74" modified="2016-09-07" version="1">MLEIACFNVSSAIAAAEAGADRIELCADYAAGGVTPSVDAWDEIRKATSKPINAMIRPRPGDFVYTTLQLYQMKLDILNFKPVASGFVFGILDSENRVDEARNRELVEMAAGLPCTFHRAFDTVPDQAEAVESLIRCGFTSILTSGGPADAVSGAGNVARLQKEFGSRITFILGGGIRSSNLAALREQTDVPWYHSAAITQPGEMVDRDEVSRLQSILKNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CCB6</accession>
    <name>A0A177CCB6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">p-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CC84DRAFT_1187505</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NBP35-CFD1 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP2/CFD1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG04427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034792.1">
        <property type="nucleotide sequence ID" value="XM_018180933.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CCB6"/>
    <dbReference type="FunCoup" id="A0A177CCB6">
        <property type="interactions" value="151"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CCB6"/>
    <dbReference type="GeneID" id="28764419"/>
    <dbReference type="InParanoid" id="A0A177CCB6"/>
    <dbReference type="OrthoDB" id="3900342at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904564">
        <property type="term" value="C:cytosolic [4Fe-4S] assembly scaffold complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140663">
        <property type="term" value="F:ATP-dependent FeS chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd02037">
        <property type="entry name" value="Mrp_NBP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001300">
        <property type="entry name" value="Cytosolic Fe-S cluster assembly factor CFD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02040">
        <property type="entry name" value="Mrp_NBP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03039">
        <property type="entry name" value="NUBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000808">
        <property type="entry name" value="Mrp-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019591">
        <property type="entry name" value="Mrp/NBP35_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028600">
        <property type="entry name" value="NUBP2/Cfd1_eukaryotes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033756">
        <property type="entry name" value="YlxH/NBP35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23264:SF19">
        <property type="entry name" value="CYTOSOLIC FE-S CLUSTER ASSEMBLY FACTOR NUBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23264">
        <property type="entry name" value="NUCLEOTIDE-BINDING PROTEIN NBP35 YEAST -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10609">
        <property type="entry name" value="ParA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01215">
        <property type="entry name" value="MRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 9" id="KW-0408">Iron</keyword>
    <keyword evidence="8 9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="15"/>
            <end position="22"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="224"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAG04427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="327" mass="34879" checksum="B4B956937FAF44C4" modified="2016-09-07" version="1">MPLENIRHIVLVLSGKGGVGKSSITTQLALALSLQGKSVGVLDIDLTGPSIPRFFGIEESRVKQAPGGWIPVEVHAEQTLPLTQHAIANANGSTHEKEQEQGQGTHVGALSCMSLGFILPNRGDAVIWRGPKKTAMVRQFLTDVLWPELDFLLVDTPPGTSDEHISLLETLLKTTAGTSQLAGAVVVTTPQAIAISDVKKELNFCAKTGVRVLGVVENMAGFVCPNCSECCNVFSKGGGEVMATEFHVPFLGSVPIDPAFVMLIEEGVRPRYPKGTVAGGKALVEREEGVESKEGLLVDKYRECSLAPVFEGFVGRLVADVEGRTRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CCC4</accession>
    <name>A0A177CCC4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_1246584</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG04532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034897.1">
        <property type="nucleotide sequence ID" value="XM_018184206.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CCC4"/>
    <dbReference type="STRING" id="1460663.A0A177CCC4"/>
    <dbReference type="GeneID" id="28767692"/>
    <dbReference type="InParanoid" id="A0A177CCC4"/>
    <dbReference type="OrthoDB" id="3251668at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="308"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="152"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="202"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="152"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="204"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="268"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAG04532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="351" mass="39238" checksum="9FDF9605ABECFE72" modified="2016-09-07" version="1">MDNIDDDLDLCYHRDLKTDVYYRCPSSEVTSPPVVYADFEKNTASLIPVDIVTEFVFNKASTITIAVTQQPNLNALFEPADYPRRITIEHALCYGIDGKERLKLQRAIARGFIEAIQAIDGFKYTELQAWSKDGSDGARFKYVCLDSLQNRNRKSKTKRKNSSKDADGGNAQNISKRSELSTYDCGGAIYARFSTKREAVNALSSNSTTSTGTSNGTKPKKWKKSQNDHHVEAHSAFQDQELDMSTSPEASKAGSKKKRKKNAVQLEGSGSATKNNLKTKQAKSPSKACQEAPARDPTPEPVQPVKDICLHCCKKRIKCNEAKPNCDQCLRVLWTCQYRHLVQRSARRTDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CDE2</accession>
    <name>A0A177CDE2_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Protein PBN1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CC84DRAFT_1259061</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Required for proper folding and/or the stability of a subset of proteins in the endoplasmic reticulum. Component of glycosylphosphatidylinositol-mannosyltransferase 1 which transfers the first of the 4 mannoses in the GPI-anchor precursors during GPI-anchor biosynthesis. Probably acts by stabilizing the mannosyltransferase GPI14.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Endoplasmic reticulum membrane</location>
            <topology evidence="11">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type III membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the PIGX family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG05664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036029.1">
        <property type="nucleotide sequence ID" value="XM_018184878.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CDE2"/>
    <dbReference type="STRING" id="1460663.A0A177CDE2"/>
    <dbReference type="GeneID" id="28768364"/>
    <dbReference type="InParanoid" id="A0A177CDE2"/>
    <dbReference type="OrthoDB" id="5546453at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990529">
        <property type="term" value="C:glycosylphosphatidylinositol-mannosyltransferase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000030">
        <property type="term" value="F:mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042322">
        <property type="entry name" value="Pbn1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013233">
        <property type="entry name" value="PIG-X/PBN1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28533">
        <property type="entry name" value="PROTEIN PBN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28533:SF1">
        <property type="entry name" value="PROTEIN PBN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08320">
        <property type="entry name" value="PIG-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00780">
        <property type="entry name" value="PIG-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 11" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="469"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU366056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OAG05664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="505" mass="54701" checksum="90C50B869E2538C1" modified="2016-09-07" version="1">MKQRITYLVEDPDSFTPEQLQVKDGSLSLIGLKAVQEHRVTFTLDELPTELRTSLKQWRELHIKWASHKPYTAIPPFTSRVSPGLHVSFTRRKSETTGQLCELIHTFFDPAAKCSSGPDANEVATPLFQVDEDGKQTASASLQYYTYLPHLTHFASFLSSNLCSASSQCADHAASLQDASSFDIDYTPSSRTLTLTSLTTPPSSGWKTLIPAPSPDRPGDTTEVGVLTHEPNPDPEDLAFAGFLTTLGPDAAPKPTRFQAPARHYPLPASSRDLAYSASFATPTGLHPTLELSFSPAGRLAPPDESCGLYAHLTLPSALFLDRYQFSDPLFLASKNLVSLRHVTGATDLEAPDWVVPQWGSAALVQLALPEQSPKDANTTASIPLHLRYLPAAPRAHTLVPAPWPVVFWACDMAQDPSGNPFDRVNLGYETAFAPGTRFMHVPPATGNGTAELVSWIAVPVLDTSAAGWVEMGTIGVVVAAFAGLCWVLFSGGGKREVQQDKKTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CDR1</accession>
    <name>A0A177CDR1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Alcohol dehydrogenase 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_1165270</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG04908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035273.1">
        <property type="nucleotide sequence ID" value="XM_018178681.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CDR1"/>
    <dbReference type="STRING" id="1460663.A0A177CDR1"/>
    <dbReference type="GeneID" id="28762167"/>
    <dbReference type="InParanoid" id="A0A177CDR1"/>
    <dbReference type="OrthoDB" id="1879366at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08297">
        <property type="entry name" value="CAD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000039">
        <property type="entry name" value="Alcohol dehydrogenase AdhP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940:SF5">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="7">
        <location>
            <begin position="18"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAG04908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="358" mass="37376" checksum="7EB8B53297087637" modified="2016-09-07" version="1">MAADLPKKYKAAVYDKPGSISTKIEELDMPEPGPGEVLINLSHSGVCHSDMGIMMQSWKHMPFPTQAGQVGGHEGVGKIVKMGPATDTSSVGLGDRVGIKWMAGICETCDACRVGLDASCAKGKVSGYYTPGTFQQYVLAPANYVTPIPDGLDSAAAAPLLCAGVTVYSALRKSRTQSGNFVVILGAGGGLGHLGTQFASRGMALRVIGIDHSSKKDLVLESGAEHFIPIDGTDDVAGAVKDLTGGLGAHAVVVLTSNNKAYASSVGLLRHGGTVVCIGVPEGDPVPFQATPAQLIMSAITIVGVAVGTRRDAIETLDFAARGVVKTHFRVEKLDKLTEVFKEMDEQKMQGRVVIDLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CDW2</accession>
    <name>A0A177CDW2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">FMN-dependent alpha-hydroxy acid dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CC84DRAFT_1260242</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG04968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035333.1">
        <property type="nucleotide sequence ID" value="XM_018184979.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CDW2"/>
    <dbReference type="STRING" id="1460663.A0A177CDW2"/>
    <dbReference type="GeneID" id="28768465"/>
    <dbReference type="InParanoid" id="A0A177CDW2"/>
    <dbReference type="OrthoDB" id="25826at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000132">
        <property type="entry name" value="FMN dependent dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012133">
        <property type="entry name" value="Alpha-hydoxy_acid_DH_FMN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000262">
        <property type="entry name" value="FMN-dep_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037396">
        <property type="entry name" value="FMN_HAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008259">
        <property type="entry name" value="FMN_hydac_DH_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578:SF86">
        <property type="entry name" value="DEPENDENT DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G02720)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578">
        <property type="entry name" value="S -2-HYDROXY-ACID OXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01070">
        <property type="entry name" value="FMN_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000138">
        <property type="entry name" value="Al-hdrx_acd_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00557">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51349">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 7" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN hydroxy acid dehydrogenase" evidence="8">
        <location>
            <begin position="32"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="331"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="111"/>
            <end position="113"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="307"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="329"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="331"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="334"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="365"/>
            <end position="369"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="388"/>
            <end position="389"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000138-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000138-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAG04968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="443" mass="48492" checksum="C844675DE4F5700A" modified="2016-09-07" version="1">MGDSSNPKPATQYEPDPTAFVQFQREIYASLRKPAFSTKPSQWEAQARKILPEPNFMYIYGSASSESTYASNVSAFERYRLRPWMLVQATHRDLSVELFGKLYKSPIFAAPVGVQEIAHHDAEEATARACASVSVPMILSTAATRSIEQVAKANGDGDRWFQLYWPVPQAEEVTASLLNRAKSNGFKVLVVTLDTFLLGWRPRDLDESYLPFAWGQGCQNAFTDPAFQRMYERLQAADTRSATEKIGEIWSILKRPGSLTGAAKILANAAIMKKAQLFMSLTASGAYRDWNDLSSLRKHWDGPIVLKGIQTLEDAHRAIEYGMDGIIVSNHGGRQLDGAIASLDALAEIGGDEKVKSSNLTILFDSGIRTGSDVLKAIALGAKAVLIGRPYIYGLAMGGEVGVKHVLSCLLADTDNSLANLGKTSLSQISRNDLRVIQSLAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CF10</accession>
    <name>A0A177CF10_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CC84DRAFT_1163959</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG05408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035773.1">
        <property type="nucleotide sequence ID" value="XM_018178373.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CF10"/>
    <dbReference type="STRING" id="1460663.A0A177CF10"/>
    <dbReference type="GeneID" id="28761859"/>
    <dbReference type="InParanoid" id="A0A177CF10"/>
    <dbReference type="OrthoDB" id="10266265at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF40">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="22"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="58"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="128"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="672"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="762"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="93"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="142"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="672"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="774"/>
            <end position="791"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAG05408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="791" mass="88598" checksum="ED2FF6C58C2D0612" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CFY1</accession>
    <name>A0A177CFY1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CC84DRAFT_1217720</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG06515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036880.1">
        <property type="nucleotide sequence ID" value="XM_018182921.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CFY1"/>
    <dbReference type="STRING" id="1460663.A0A177CFY1"/>
    <dbReference type="GeneID" id="28766407"/>
    <dbReference type="InParanoid" id="A0A177CFY1"/>
    <dbReference type="OrthoDB" id="2285533at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090575">
        <property type="term" value="C:RNA polymerase II transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050936">
        <property type="entry name" value="AP-1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40621:SF9">
        <property type="entry name" value="MEAB PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40621">
        <property type="entry name" value="TRANSCRIPTION FACTOR KAPC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="5">
        <location>
            <begin position="55"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="129"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="321"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="74"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="15"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="234"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="271"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="286"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAG06515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="412" mass="45125" checksum="815427EDB5F3D55E" modified="2016-09-07" version="1">MTAPVGKQEAERDGSTSSIASSPEPEPAAYTQDNPQQQQKRKGGRKPIYATSEERKQRNRQAQAAFRERRTEYIKQLESTIKHHEETLQNLQQSHRSAADECLMLRYKNSLLERILLEKGIDVQAELQAKTGSPNLGPTRQNAPTTASPNQPPLQQRAMLNRQQQNRRSMGGLPKAEGVPGLPMIQPDGAIPNRSPLSQPTPGSHLPSPVASATRSPNFVAHGTSVSPNFGSIPPQQQPQRHQQLQPQPPRSQFTPIMGPQRPSVITNQPSSNGLSSASTGSGASVMTQSSTAGGTQAYFPTPYSEHMTQLEQEYDEQNDMLDQEDPSDHSAGPGPYPNPFQSNAMQSQNMQPPMPPAQNPPYTNNGPVAANEANHAFNGMNHLFDPYDPMLDADPFGLSASMHFPTMYESR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CFZ8</accession>
    <name>A0A177CFZ8_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Integral membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1090445</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG06246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036611.1">
        <property type="nucleotide sequence ID" value="XM_018174354.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CFZ8"/>
    <dbReference type="STRING" id="1460663.A0A177CFZ8"/>
    <dbReference type="GeneID" id="28757840"/>
    <dbReference type="InParanoid" id="A0A177CFZ8"/>
    <dbReference type="OrthoDB" id="2603at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="121"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="155"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="257"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="291"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="330"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG06246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="407" mass="44829" checksum="B30E074183530777" modified="2016-09-07" version="1">MESSDSTLPNALKRNKAFHPTHEPFGQEAELHVQKDSVSGPVSFLNPTNAHFRHATRPDVRFKWSSRNNRKGRHALLIDRHQITSKTQGATPRPTSSPRSIARGLWRMLTYYPVWDVSFDVAYVFTLGSVIWVTNAFFVFLPLVRPTTEFSNEELYGGGVTAFIGATVFEVGSILLMAEAVNENQSGCFGWAVSQALSRGDDDAAAAPTPSQSHCTHHHPNRHNLVGKGRRPVTKGAPDTHPRAWRWWPSGHDLHSLGFLASLAQLCGASIFWIAGLTALPGIYDHLSRPLAIAFYWTPQVLGGLGFVVSGTLFMLETQPTWWKPAPRTLGWWIGAWNLVGGVGFTLCPAFGYDESSWAQYQACLSTFWGSWAFLIGSGLQWYESLEKFPVEVDGEGTGGGGAKEAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CGX7</accession>
    <name>A0A177CGX7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">cutinase</fullName>
            <ecNumber evidence="2">3.1.1.74</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CC84DRAFT_1217245</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>cutin + H2O = cutin monomers.</text>
            <dbReference type="EC" id="3.1.1.74"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the cutinase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.74" evidence="2"/>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG05957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036322.1">
        <property type="nucleotide sequence ID" value="XM_018182874.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CGX7"/>
    <dbReference type="GeneID" id="28766360"/>
    <dbReference type="InParanoid" id="A0A177CGX7"/>
    <dbReference type="OrthoDB" id="2975078at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050525">
        <property type="term" value="F:cutinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000675">
        <property type="entry name" value="Cutinase/axe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011150">
        <property type="entry name" value="Cutinase_monf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48250:SF2">
        <property type="entry name" value="CUTINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48250">
        <property type="entry name" value="CUTINASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01083">
        <property type="entry name" value="Cutinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01110">
        <property type="entry name" value="Cutinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008058148" description="cutinase" evidence="9">
        <location>
            <begin position="22"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="38"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00034045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR611150-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAG05957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="285" mass="29729" checksum="FD7903AAD02A7E7A" modified="2016-09-07" version="1">MLPLALLLPALTLATPAPSFASDTSTDMDAVIRGGTPCASHAVLFARGTFDSGNLGVWVGPFLKDSVLSALAGDVHVQGVNAGDYAANLADYVKEGGSESCADACARTVDAYVEKCPGANVFVSGWSQGALCAHKCVNRISPNAATQLKGLATFGDENALMDEPELVPSGLPFKAYCNEDNTSPDLLCTQSALSGVDLPSSIAAWKAEVYDNLALLKDVATNPAQLKAAAALPVSILSGFFGVSRYFLLDVATGNVRRWLVLPPHFVYGNNGMADQAAKWMASLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CIL9</accession>
    <name>A0A177CIL9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CBM1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CC84DRAFT_634948</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG07101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037466.1">
        <property type="nucleotide sequence ID" value="XM_018186974.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CIL9"/>
    <dbReference type="GeneID" id="28770460"/>
    <dbReference type="InParanoid" id="A0A177CIL9"/>
    <dbReference type="OrthoDB" id="2119228at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030248">
        <property type="term" value="F:cellulose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000254">
        <property type="entry name" value="CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035971">
        <property type="entry name" value="CBD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00734">
        <property type="entry name" value="CBM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00236">
        <property type="entry name" value="fCBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57180">
        <property type="entry name" value="Cellulose-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51164">
        <property type="entry name" value="CBM1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008058226" description="CBM1 domain-containing protein" evidence="3">
        <location>
            <begin position="19"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="CBM1" evidence="4">
        <location>
            <begin position="99"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="43"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="54"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAG07101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="145" mass="15513" checksum="98158B2FF46BDDFB" modified="2016-09-07" version="1">MLFNELALLSALSAGCLAVQADRLAPRQGDGSIIFTTICLGPRCSDAPAPTTAPPKTTLRTTTTSKKTTSSTKEPTKTSSPSQPTKTQTEEVGPSSTRCPVPLYYQCGGYHDGKPWTGCEVCVKGAKCIWQNDWYYQCVADDGSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CIX4</accession>
    <name>A0A177CIX4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Large ribosomal subunit protein bL17m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CC84DRAFT_1117472</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the bacterial ribosomal protein bL17 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG07266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037631.1">
        <property type="nucleotide sequence ID" value="XM_018175495.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CIX4"/>
    <dbReference type="FunCoup" id="A0A177CIX4">
        <property type="interactions" value="597"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CIX4"/>
    <dbReference type="GeneID" id="28758981"/>
    <dbReference type="InParanoid" id="A0A177CIX4"/>
    <dbReference type="OrthoDB" id="275000at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1030.10:FF:000005">
        <property type="entry name" value="Probable 50S ribosomal protein L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1030.10">
        <property type="entry name" value="Ribosomal protein L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01368">
        <property type="entry name" value="Ribosomal_bL17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000456">
        <property type="entry name" value="Ribosomal_bL17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047859">
        <property type="entry name" value="Ribosomal_bL17_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036373">
        <property type="entry name" value="Ribosomal_bL17_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00059">
        <property type="entry name" value="L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14413:SF16">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL17M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14413">
        <property type="entry name" value="RIBOSOMAL PROTEIN L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01196">
        <property type="entry name" value="Ribosomal_L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64263">
        <property type="entry name" value="Prokaryotic ribosomal protein L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01167">
        <property type="entry name" value="RIBOSOMAL_L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 8 10" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="241"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="241"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAG07266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="269" mass="31239" checksum="809E34DD17970EA6" modified="2016-09-07" version="1">MAGGHMKYRHLSRSSSHRQALLRNLVTSLFKQESITTTWHKAKEAQRLAEKLVTLGKKNTEATRRRAHQIFFEPNELVPKLFGPIRERYLERPGGYTRVLRIEPTKEDQAESAILELVDGPKDMRFAMTAKTLSNLPETTRMNELTAKNVKKVTQFRQDGVEHLRNMVEKMREGKKKRWDTRTLLGPRRVYLLEERQVRDRHLPEPVNDGELPNPVKMLHGGVLQKGTKIWNVRDIVERQKNKSKEGARLEAEKAQKKQQKQPKALQSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CKC8</accession>
    <name>A0A177CKC8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1214529</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG07975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038340.1">
        <property type="nucleotide sequence ID" value="XM_018182637.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CKC8"/>
    <dbReference type="GeneID" id="28766123"/>
    <dbReference type="InParanoid" id="A0A177CKC8"/>
    <dbReference type="OrthoDB" id="10645001at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48125:SF12">
        <property type="entry name" value="AT HOOK TRANSCRIPTION FACTOR FAMILY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48125">
        <property type="entry name" value="LP07818P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="316"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="498"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="573"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="752"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="380"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="395"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="408"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="454"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="599"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="667"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="752"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="764"/>
            <end position="773"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG07975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="818" mass="89843" checksum="48133FF82FC0C20F" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CKD9</accession>
    <name>A0A177CKD9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Oleate-induced peroxisomal protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1163884</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG07776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038141.1">
        <property type="nucleotide sequence ID" value="XM_018178356.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CKD9"/>
    <dbReference type="STRING" id="1460663.A0A177CKD9"/>
    <dbReference type="GeneID" id="28761842"/>
    <dbReference type="InParanoid" id="A0A177CKD9"/>
    <dbReference type="OrthoDB" id="10265837at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1050.10:FF:000001">
        <property type="entry name" value="Putative Non-specific lipid-transfer protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1050.10">
        <property type="entry name" value="SCP2 sterol-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003033">
        <property type="entry name" value="SCP2_sterol-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036527">
        <property type="entry name" value="SCP2_sterol-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10094:SF25">
        <property type="entry name" value="SCP2 STEROL-BINDING DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10094">
        <property type="entry name" value="STEROL CARRIER PROTEIN 2 SCP-2 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02036">
        <property type="entry name" value="SCP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55718">
        <property type="entry name" value="SCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCP2" evidence="1">
        <location>
            <begin position="23"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG07776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="127" mass="13457" checksum="7B9426A934F6A6AE" modified="2016-09-07" version="1">MSLKSDAFPSSVAFDAIASSLKNDEAGRKDAIKKGNAIFAFDLKNASGATESWYIDLKETGEVGKGAPPKKASVTLSLSDENFGKLVTGKANAQKLFMSGKLKVKGDVMKATKMEPILKKAQTSAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CLK2</accession>
    <name>A0A177CLK2_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein HRI1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1257262</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038758.1">
        <property type="nucleotide sequence ID" value="XM_018184718.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CLK2"/>
    <dbReference type="FunCoup" id="A0A177CLK2">
        <property type="interactions" value="13"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CLK2"/>
    <dbReference type="GeneID" id="28768204"/>
    <dbReference type="InParanoid" id="A0A177CLK2"/>
    <dbReference type="OrthoDB" id="4045395at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd11693">
        <property type="entry name" value="HRI1_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.320">
        <property type="entry name" value="Protein HRI1, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031818">
        <property type="entry name" value="Hri1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043047">
        <property type="entry name" value="Hri1_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16815">
        <property type="entry name" value="HRI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG08393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="323" mass="35897" checksum="93017503BB2F886D" modified="2016-09-07" version="1">MPADPNPANASISHRTYFYPLPHPLPPGTPIPYSAGLPSQNPLDLPATPVEPTSSLVLTSTTKQFIDVRVFKPILEEDPELPNEGGPRARLDWAFAGTSYSVPIPDPYPHGVTEHAATASRHAEHHRAWPAPITHATWTHWLDSRHPISSSPTGMPKDEGTMFPLSATQTLEFGEGINPATGKMWAYEELWTDEAPRAAPTREEADPLVYSIVLRCEDEAHDVRGVVMRLGRYCQGILMKGGYVSVERWEWVVEDGLDKEVGGWKRSVRIGDQFLPCAPTFTPAVLSVGGKVRYWDYEWVCEEKVAWREGPGATEAGVRERQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CM67</accession>
    <name>A0A177CM67_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">triacylglycerol lipase</fullName>
            <ecNumber evidence="6">3.1.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Autophagy-related protein 15</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">CC84DRAFT_1161944</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12044"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17855"/>
            <dbReference type="ChEBI" id="CHEBI:18035"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="EC" id="3.1.1.3"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">Binds to both phosphatidylinositol (PI) and phosphatidylinositol 3,5-bisphosphate (PIP2).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endosome</location>
            <location evidence="3">Multivesicular body membrane</location>
            <topology evidence="3">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Prevacuolar compartment membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.3" evidence="6"/>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG07899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038264.1">
        <property type="nucleotide sequence ID" value="XM_018177867.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CM67"/>
    <dbReference type="FunCoup" id="A0A177CM67">
        <property type="interactions" value="49"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CM67"/>
    <dbReference type="GeneID" id="28761353"/>
    <dbReference type="InParanoid" id="A0A177CM67"/>
    <dbReference type="OrthoDB" id="58570at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032585">
        <property type="term" value="C:multivesicular body membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005775">
        <property type="term" value="C:vacuolar lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004620">
        <property type="term" value="F:phospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034496">
        <property type="term" value="P:multivesicular body membrane disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046461">
        <property type="term" value="P:neutral lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006660">
        <property type="term" value="P:phosphatidylserine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00519">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000129">
        <property type="entry name" value="Autophagy related lipase Atg15, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050805">
        <property type="entry name" value="ATG15_Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47175">
        <property type="entry name" value="LIPASE ATG15-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47175:SF2">
        <property type="entry name" value="LIPASE ATG15-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0072">Autophagy</keyword>
    <keyword evidence="8" id="KW-0967">Endosome</keyword>
    <keyword evidence="16" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 20" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="14" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="19" id="KW-0732">Signal</keyword>
    <keyword evidence="11" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="19">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008058365" description="triacylglycerol lipase" evidence="19">
        <location>
            <begin position="28"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="524"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="601"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="528"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00029828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="OAG07899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="659" mass="72004" checksum="2555B25C86098C7D" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CMV8</accession>
    <name>A0A177CMV8_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1086404</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038472.1">
        <property type="nucleotide sequence ID" value="XM_018174159.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CMV8"/>
    <dbReference type="STRING" id="1460663.A0A177CMV8"/>
    <dbReference type="GeneID" id="28757645"/>
    <dbReference type="InParanoid" id="A0A177CMV8"/>
    <dbReference type="OrthoDB" id="3210378at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG08107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="644" mass="72174" checksum="130620703C225DB5" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CMW6</accession>
    <name>A0A177CMW6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_593194</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039230.1">
        <property type="nucleotide sequence ID" value="XM_018186808.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CMW6"/>
    <dbReference type="GeneID" id="28770294"/>
    <dbReference type="InParanoid" id="A0A177CMW6"/>
    <dbReference type="OrthoDB" id="10618233at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="102"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG08865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="177" mass="19422" checksum="A32099DC68BC2BA9" modified="2016-09-07" version="1">MSTAAKAGIGAGCGVGALVICALVFFLWRRHREKSNHQHAAALTSAGQDSNPNPHTARQPMTEEQSAKYAATADQMLHSPRERYSDLMPTTGTTSPSPPYAPAGYGYELASSPVPQQYYPRPPSPRMSEQQRMYSPGNSVEMYHPVPVEVSGLHSPRPQPAYPMRGTDPSQVDEWRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CN06</accession>
    <name>A0A177CN06_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_584880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039041.1">
        <property type="nucleotide sequence ID" value="XM_018186779.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CN06"/>
    <dbReference type="GeneID" id="28770265"/>
    <dbReference type="InParanoid" id="A0A177CN06"/>
    <dbReference type="OrthoDB" id="3800034at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008058496" description="Secreted protein" evidence="1">
        <location>
            <begin position="32"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG08676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="107" mass="11582" checksum="F845F3C576E27D55" modified="2016-09-07" version="1">MFIFIKMLFRNLPAAAVACLVLPAFQIVVHAHSGNREAVRACGVILRDMPERLASSFCSSYAEIPDITSTCTSTKTRKITVTSIASCSATTTASTSYVERTTFLSII</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CN14</accession>
    <name>A0A177CN14_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CC84DRAFT_1173855</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038727.1">
        <property type="nucleotide sequence ID" value="XM_018180061.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CN14"/>
    <dbReference type="GeneID" id="28763547"/>
    <dbReference type="InParanoid" id="A0A177CN14"/>
    <dbReference type="OrthoDB" id="3777487at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF8">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="2"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="111"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAG08362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="170" mass="18914" checksum="95F82BC0DCE80818" modified="2016-09-07" version="1">MSCINILTDIFMLALPLPVVWGLRINKTQKWLVSLSFIMGGSACIVCLVRLLFVLRVASTPDPTWLKGDSIPSGITSTFELSVGIFAASFPTYRPLYRWLSKGTLEDTTAHSNSFGSGRQWNGRSQAQRPDPHRIIKLTTIRSEVDPRDTNEERLYVVGSNVSTNRDGTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CNB1</accession>
    <name>A0A177CNB1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7896 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1257755</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG09025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039390.1">
        <property type="nucleotide sequence ID" value="XM_018184759.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CNB1"/>
    <dbReference type="STRING" id="1460663.A0A177CNB1"/>
    <dbReference type="GeneID" id="28768245"/>
    <dbReference type="InParanoid" id="A0A177CNB1"/>
    <dbReference type="OrthoDB" id="5377599at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057218">
        <property type="entry name" value="DUF7896"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42031">
        <property type="entry name" value="KEY LIME PATHOGENICITY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42031:SF1">
        <property type="entry name" value="KEY LIME PATHOGENICITY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25438">
        <property type="entry name" value="DUF7896"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7896" evidence="2">
        <location>
            <begin position="436"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="310"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="477"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="519"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="314"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="477"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="519"/>
            <end position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG09025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="616" mass="67816" checksum="EB15A19B7576EBED" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CNT1</accession>
    <name>A0A177CNT1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">YVTN repeat-like/Quino protein amine dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1086073</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039226.1">
        <property type="nucleotide sequence ID" value="XM_018174138.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CNT1"/>
    <dbReference type="STRING" id="1460663.A0A177CNT1"/>
    <dbReference type="GeneID" id="28757624"/>
    <dbReference type="InParanoid" id="A0A177CNT1"/>
    <dbReference type="OrthoDB" id="20669at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43991:SF12">
        <property type="entry name" value="WD REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_8G05640)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43991">
        <property type="entry name" value="WD REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_8G05640)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="269"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG08861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="448" mass="49895" checksum="1033987E9140E757" modified="2016-09-07" version="1">MGLEEAEGDHLSVITRDDLAGEDRDYQGIIWSKRMPRAEFRSKRRNEEKARLSKVMRQYNKRHPPINQTENFFSFRRMDKRHRPWGPHFQLRNMMAVTSRQDIYYAERLKGIFKTDASGSKAQPIIDTTKHTVNGNMPMITTMAAMDQVLIAGGFEGEYAVVDLASNNGPHTSMDVIRDWAPETKSFITNHVHLFNDRSSYTPQAVLSSNDFSLRVLDCATNTFRYKFPFSAAVNCSATSADGRLRVVAGDFPETLITNAETGETLQTLRAHEGDAFACAWADDGIHVASAAQDGTIAVWDARCWRAPLAVLPCELSIPRVLRFSPLGSGPRVLVVAEADDYVSVINATTFANKQVFDFFGQTGGVDFAPDGQSLFVANSEFGLGGIIELERAGGWDAERVLGDVEERYWDGKVVDWAGEDEMDGNYRVLCGKGERNRRGLDLGSVDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CNZ5</accession>
    <name>A0A177CNZ5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1086459</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039003.1">
        <property type="nucleotide sequence ID" value="XM_018174162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CNZ5"/>
    <dbReference type="GeneID" id="28757648"/>
    <dbReference type="InParanoid" id="A0A177CNZ5"/>
    <dbReference type="OrthoDB" id="5588148at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG08638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="61" mass="7033" checksum="6E8CB02D92A0B2E9" modified="2016-09-07" version="1" fragment="single">PKPTCVRDIRVFISFINYYWRFITNFSRLALPLTVLTKKAPNSARQGPAIRREESVPLNIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CPJ0</accession>
    <name>A0A177CPJ0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1215164</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039052.1">
        <property type="nucleotide sequence ID" value="XM_018182700.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CPJ0"/>
    <dbReference type="GeneID" id="28766186"/>
    <dbReference type="InParanoid" id="A0A177CPJ0"/>
    <dbReference type="OrthoDB" id="3790550at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="270"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="281"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="302"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG08687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="522" mass="57246" checksum="F89DA758D79CD360" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CPU4</accession>
    <name>A0A177CPU4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Palmitoyltransferase</fullName>
            <ecNumber evidence="10">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CC84DRAFT_1160676</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="10">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DHHC palmitoyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="10"/>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG09543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039908.1">
        <property type="nucleotide sequence ID" value="XM_018177552.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CPU4"/>
    <dbReference type="STRING" id="1460663.A0A177CPU4"/>
    <dbReference type="GeneID" id="28761038"/>
    <dbReference type="InParanoid" id="A0A177CPU4"/>
    <dbReference type="OrthoDB" id="302728at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12246">
        <property type="entry name" value="PALMITOYLTRANSFERASE ZDHHC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0564">Palmitate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="158"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="199"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="12">
        <location>
            <begin position="111"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="282"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="395"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="512"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="290"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="395"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="442"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="459"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="512"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="569"/>
            <end position="587"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OAG09543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="587" mass="67234" checksum="F46F91A7B30ADF9B" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CPZ2</accession>
    <name>A0A177CPZ2_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ribonuclease T2</fullName>
            <ecNumber evidence="2">4.6.1.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CC84DRAFT_598461</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the RNase T2 family.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.19" evidence="2"/>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039325.1">
        <property type="nucleotide sequence ID" value="XM_018186823.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CPZ2"/>
    <dbReference type="GeneID" id="28770309"/>
    <dbReference type="InParanoid" id="A0A177CPZ2"/>
    <dbReference type="OrthoDB" id="435754at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033897">
        <property type="term" value="F:ribonuclease T2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.730.10:FF:000020">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.730.10">
        <property type="entry name" value="Ribonuclease T2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001568">
        <property type="entry name" value="RNase_T2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036430">
        <property type="entry name" value="RNase_T2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018188">
        <property type="entry name" value="RNase_T2_His_AS_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033130">
        <property type="entry name" value="RNase_T2_His_AS_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11240">
        <property type="entry name" value="RIBONUCLEASE T2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11240:SF17">
        <property type="entry name" value="RIBONUCLEASE T2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00445">
        <property type="entry name" value="Ribonuclease_T2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55895">
        <property type="entry name" value="Ribonuclease Rh-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00530">
        <property type="entry name" value="RNASE_T2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00531">
        <property type="entry name" value="RNASE_T2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008058549" description="ribonuclease T2" evidence="5">
        <location>
            <begin position="18"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAG08960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="324" mass="36439" checksum="262E0D3700D69D59" modified="2016-09-07" version="1">MRSTSAAIVVLASTASAQLYPGQSPYNHTCELQNPLLSCPPQDPLLVDSCCVETFGGLVLSTQFWSTYTGGESAGQLLPQDTWTLHGLWPDFCNGSYTQYCDLTRQYDPIPSPNTTTGKPDGVPVPAYNGSNIGTFLEPFGKYDLLDYMDNYWIAQNQDNPGFWGHEFSKHATCFSTFNVPCYGPQYRKHEEVVDFFETAIRYYKRFPTFDWLEEADITPSNCTTYSYEEIRDPLVKQHGGLPFIGCTGPRYNTTEAGKNSTDNGYTVLSEVWYYEYVYGRPQEMNTVPVNASATYYTNCAKSEGAIHYPERTNGSVRVPTLPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CR26</accession>
    <name>A0A177CR26_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">3-hydroxyisobutyrate dehydrogenase</fullName>
            <ecNumber evidence="3">1.1.1.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CC84DRAFT_1184145</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>3-hydroxy-2-methylpropanoate + NAD(+) = 2-methyl-3-oxopropanoate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17681"/>
            <dbReference type="ChEBI" id="CHEBI:11805"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57700"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.31"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid degradation; L-valine degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HIBADH-related family. 3-hydroxyisobutyrate dehydrogenase subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.31" evidence="3"/>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG09973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040338.1">
        <property type="nucleotide sequence ID" value="XM_018180728.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CR26"/>
    <dbReference type="STRING" id="1460663.A0A177CR26"/>
    <dbReference type="GeneID" id="28764214"/>
    <dbReference type="InParanoid" id="A0A177CR26"/>
    <dbReference type="OrthoDB" id="21615at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008442">
        <property type="term" value="F:3-hydroxyisobutyrate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006574">
        <property type="term" value="P:L-valine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000006">
        <property type="entry name" value="3-hydroxyisobutyrate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000630">
        <property type="entry name" value="3-hydroxyisobutyrate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002204">
        <property type="entry name" value="3-OH-isobutyrate_DH-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029154">
        <property type="entry name" value="HIBADH-like_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015815">
        <property type="entry name" value="HIBADH-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22981:SF7">
        <property type="entry name" value="3-HYDROXYISOBUTYRATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22981">
        <property type="entry name" value="3-HYDROXYISOBUTYRATE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14833">
        <property type="entry name" value="NAD_binding_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000103">
        <property type="entry name" value="HIBADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00895">
        <property type="entry name" value="3_HYDROXYISOBUT_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0101">Branched-chain amino acid catabolism</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6-phosphogluconate dehydrogenase NADP-binding" evidence="9">
        <location>
            <begin position="38"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="3-hydroxyisobutyrate dehydrogenase-like NAD-binding" evidence="10">
        <location>
            <begin position="210"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000103-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF14833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OAG09973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="342" mass="36159" checksum="21E4BE5B246F1DDF" modified="2016-09-07" version="1">MRTVSAIASPLRRNAPVAARQASRRCFSSTRNVQANWGFIGLGRMGFAMAKNLRAKIPAEDTLFVQDVNTAASKKFLEENPTGVRIADNVREVAEKAETIITCLPEPQHVSSVYKQMLEPATLLTEGTTNQPRLFIDTSTIDPTTSGQVADAAHSSGQGVFIDAPMSGGVVGAQAGTLTFMIGAAPDAVERATAVLSLIGRRVLHLGEQGAGLKGKLANNYLLALNNVATAEAMNMGIQWGLDPKALAGMINISTGKCWPSEVNNPVPGVIEGSPASRGYEGGFGVALANKDLKLALKAAKDANIKLALGDTAKALYDEVEKVENCKGKDFSVVYRYLGGKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CRJ8</accession>
    <name>A0A177CRJ8_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Probable quinone oxidoreductase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">NADPH:quinone reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CC84DRAFT_1082008</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040519.1">
        <property type="nucleotide sequence ID" value="XM_018173960.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CRJ8"/>
    <dbReference type="FunCoup" id="A0A177CRJ8">
        <property type="interactions" value="630"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CRJ8"/>
    <dbReference type="GeneID" id="28757446"/>
    <dbReference type="InParanoid" id="A0A177CRJ8"/>
    <dbReference type="OrthoDB" id="48317at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035925">
        <property type="term" value="F:mRNA 3'-UTR AU-rich region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070402">
        <property type="term" value="F:NADPH binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003960">
        <property type="term" value="F:quinone reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05286">
        <property type="entry name" value="QOR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000053">
        <property type="entry name" value="Quinone oxidoreductase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047618">
        <property type="entry name" value="QOR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002364">
        <property type="entry name" value="Quin_OxRdtase/zeta-crystal_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48106">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE PIG3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48106:SF13">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01162">
        <property type="entry name" value="QOR_ZETA_CRYSTAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="5">
        <location>
            <begin position="17"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00043088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00070796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAG10154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="333" mass="36005" checksum="B9DD25832023FF41" modified="2016-09-07" version="1">MASLPKTMKGVWIEKTGGTEVLQYKEDIPVPEVKDGQVLVKNEFIGINYIDTYFRSGVYPLPHTPYILGREGAGTIAALGSNVPDDLQLGTRVAYMGQCAYAEYTPVDAKFTVAIPDSVDAKIAAAALLQALTAVTLIREAHPVQKGDWVLVTAAAGGVGLWLCQLLKAVGARTIAAASSPEKRELAKKNGAEVVVDYHEEDREKFTKEVIEITGGEGVAAVFDSVGKATFDSSLAAVKRKGSMVSFGNASGPVTGFALGRLSAKNVKLLRPTLFNYVYTRDELKQYAAEVWKFIEKDGLNVAIHDVYPLKDVVRATEDIQSRKTTGKLLLRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CRN8</accession>
    <name>A0A177CRN8_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1160979</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG09956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040321.1">
        <property type="nucleotide sequence ID" value="XM_018177629.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CRN8"/>
    <dbReference type="STRING" id="1460663.A0A177CRN8"/>
    <dbReference type="GeneID" id="28761115"/>
    <dbReference type="InParanoid" id="A0A177CRN8"/>
    <dbReference type="OrthoDB" id="5126878at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053178">
        <property type="entry name" value="Osmoadaptation_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38111:SF2">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G01560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38111">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="2">
        <location>
            <begin position="6"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG09956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="552" mass="62517" checksum="8BC26350F3C3CA9E" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CS21</accession>
    <name>A0A177CS21_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">L domain-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CC84DRAFT_479766</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040699.1">
        <property type="nucleotide sequence ID" value="XM_018186435.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CS21"/>
    <dbReference type="STRING" id="1460663.A0A177CS21"/>
    <dbReference type="GeneID" id="28769921"/>
    <dbReference type="InParanoid" id="A0A177CS21"/>
    <dbReference type="OrthoDB" id="676979at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000273">
        <property type="entry name" value="Leucine Rich Repeat domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15454">
        <property type="entry name" value="NISCHARIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15454:SF69">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE 11-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52075">
        <property type="entry name" value="Outer arm dynein light chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="31"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="278"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="562"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="40"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="321"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="336"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="370"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="570"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="634"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="652"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="691"/>
            <end position="704"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAG10334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="796" mass="86840" checksum="134EABF0D77E7100" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CT47</accession>
    <name>A0A177CT47_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HET-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1139435</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041068.1">
        <property type="nucleotide sequence ID" value="XM_018176237.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CT47"/>
    <dbReference type="STRING" id="1460663.A0A177CT47"/>
    <dbReference type="GeneID" id="28759723"/>
    <dbReference type="InParanoid" id="A0A177CT47"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF10">
        <property type="entry name" value="TOL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="259"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG10703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="698" mass="78869" checksum="D9DC68E4815EFF53" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CTG8</accession>
    <name>A0A177CTG8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1213631</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040653.1">
        <property type="nucleotide sequence ID" value="XM_018182554.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CTG8"/>
    <dbReference type="GeneID" id="28766040"/>
    <dbReference type="InParanoid" id="A0A177CTG8"/>
    <dbReference type="OrthoDB" id="10549443at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008058565" evidence="2">
        <location>
            <begin position="19"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG10288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="101" mass="9663" checksum="10EFB7B3EE6DA1CB" modified="2016-09-07" version="1">MPSTKVTLLMLAAIVAGADPFMVTSTTILPASVVSSDAAIVQAPASSNTSSVQPTTAPSASSGATSSQSATISGTKGAAAPSNVPFGAVFGLGLPVVLGML</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CTN1</accession>
    <name>A0A177CTN1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Lysine-specific metallo-endopeptidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1173219</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041259.1">
        <property type="nucleotide sequence ID" value="XM_018180017.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CTN1"/>
    <dbReference type="GeneID" id="28763503"/>
    <dbReference type="InParanoid" id="A0A177CTN1"/>
    <dbReference type="OrthoDB" id="3778039at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008058569" description="Lysine-specific metallo-endopeptidase domain-containing protein" evidence="1">
        <location>
            <begin position="24"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG10894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="416" mass="46579" checksum="1A3C2508CC7F1D3F" modified="2016-09-07" version="1">MVFISPQRTLLLFLTAGIFQTNAFPADGAPNSLLPTFTLLGGNGGSETGRCTGTDLENLKASYEDMCLMARSARDEIDFLTQQAALTEGDGPPKPADNAQVPVDNWKRWHRTRETYVSLFGADPFVKRGDPPGPKNPGDFIDGHKRFVRNFYDDVVNQYCGGAPAPDKSTLVCTDADFKFIQVGNVDPGDPQGRNIEVTNPQCTNIDGVWYSQNMPPGNQYDNRAPPRESGDGPVCDDPNHLAVVVRKWRAVFFCKDGLDTNVHKVVTIQDVRDKIKPASRRYKKLEDHEIVLQALTMGQLTRLDDVKRVGGEIMPVTWLHEMHHLLTRSTDEKAVDKTGNRIRITINEYNSATNQYEDHEADEKAYGYDLARDLALHNHVNAMVNPENVAFFGLAMFFSEFDWSRGFAMPLKEPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CU13</accession>
    <name>A0A177CU13_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Enoyl-CoA hydratase/isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CC84DRAFT_1161599</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Mycotoxin biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Siderophore biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 9">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041101.1">
        <property type="nucleotide sequence ID" value="XM_018177782.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CU13"/>
    <dbReference type="STRING" id="1460663.A0A177CU13"/>
    <dbReference type="GeneID" id="28761268"/>
    <dbReference type="InParanoid" id="A0A177CU13"/>
    <dbReference type="OrthoDB" id="2139957at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000074">
        <property type="entry name" value="Enoyl-CoA hydratase (AFU_orthologue AFUA_2G10650)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="entry name" value="Lyase 2-enoyl-coa Hydratase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941:SF158">
        <property type="entry name" value="ENOYL-COA HYDRATASE (AFU_ORTHOLOGUE AFUA_2G10650)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941">
        <property type="entry name" value="ENOYL-COA HYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0843">Virulence</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OAG10736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="277" mass="29943" checksum="395BEACFD66080FB" modified="2016-09-07" version="1">MSFPTATPPPPTPTFLKLSFPAPRVLLIRMDRPQALNAMSTAGQWEMHSVWAWLDAEPTLSVAVITGTGRAFSAGADLKEWNGSMGDDADPSKRMGNKPAFTPLSRRLGKKPVIAAVNGLAMGGGCEFVVNCDLVVASEDAVFGLPEVKRGVAPIGGALPRLIRTVGLQRASEFALLGEPITAQKACEWGIVNRVVKKEEVVDEAVRLASKMAENSPDAIICTRAGLREGWETASVERAVELVLDREWAELQKGENIKEGLKAFSEKRKPVWKGSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CV66</accession>
    <name>A0A177CV66_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1173393</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG11111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041476.1">
        <property type="nucleotide sequence ID" value="XM_018180031.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CV66"/>
    <dbReference type="GeneID" id="28763517"/>
    <dbReference type="InParanoid" id="A0A177CV66"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="302"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="98"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="316"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG11111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="329" mass="36229" checksum="0ECCBA3AEA602367" modified="2016-09-07" version="1">MFVRACIYLRQEHFLGHLAIGMALCSFPGGILGQARPDRMPDGSLCGDRPETSIIASASSLHFNLQAVYIRRVNCRARKLTLHPSPSRLHPGVASETMENAQETILRLQEAVKQQARAIDTIRQEQKDTVAENDALHQKTLDWSRRFPVLEDQNRKLLKKNKTKDDEIQRLRAQTAHLAQLLASQGAGVESVKEEVKDARQDIATTAQGDGTPSDRSSTKALRDVETQMEKLTVDEAEELPHTHLHAMAGAGRHADMRKALEPLLGVDITDEVCSRICDVVMEIIGPELAKANAQLSDCVASQSVSQTDPEGPGNRSSIPIPSARRSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CW53</accession>
    <name>A0A177CW53_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Purine-cytosine permease FCY21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CC84DRAFT_1139866</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041324.1">
        <property type="nucleotide sequence ID" value="XM_018176263.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CW53"/>
    <dbReference type="STRING" id="1460663.A0A177CW53"/>
    <dbReference type="GeneID" id="28759749"/>
    <dbReference type="InParanoid" id="A0A177CW53"/>
    <dbReference type="OrthoDB" id="5428495at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4160.10">
        <property type="entry name" value="Hydantoin permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026030">
        <property type="entry name" value="Pur-cyt_permease_Fcy2/21/22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31806">
        <property type="entry name" value="PURINE-CYTOSINE PERMEASE FCY2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31806:SF5">
        <property type="entry name" value="PURINE-CYTOSINE PERMEASE FCY21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002744">
        <property type="entry name" value="Pur-cyt_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="84"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="154"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="193"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="221"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="258"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="289"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="347"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="384"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="412"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="455"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="492"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="18"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR002744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAG10959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="518" mass="55782" checksum="4928BB8DA4158130" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CWG2</accession>
    <name>A0A177CWG2_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Bys1 family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1170459</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG11566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041931.1">
        <property type="nucleotide sequence ID" value="XM_018179858.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CWG2"/>
    <dbReference type="STRING" id="1460663.A0A177CWG2"/>
    <dbReference type="GeneID" id="28763344"/>
    <dbReference type="InParanoid" id="A0A177CWG2"/>
    <dbReference type="OrthoDB" id="3682664at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006771">
        <property type="entry name" value="CetA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04681">
        <property type="entry name" value="Bys1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008058671" description="Bys1 family protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG11566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="145" mass="15208" checksum="16AB7BEFE924524F" modified="2016-09-07" version="1">MRVYAPFLGLSLAATAAAAQPLLRVTNQCSENVYVVYSNDQYKAAQVTLTQGKGFQVILSGLGYSVGLSTDPAFYSEAVAKLIFGYSVNTDNGLLYYSIASDYGNPFASQSFSLTGNNGCASVNSPNGVTYACSDAASLYLTLCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CWT1</accession>
    <name>A0A177CWT1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alcohol oxidase p68</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_8385</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG11320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041685.1">
        <property type="nucleotide sequence ID" value="XM_018187607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CWT1"/>
    <dbReference type="SMR" id="A0A177CWT1"/>
    <dbReference type="STRING" id="1460663.A0A177CWT1"/>
    <dbReference type="GeneID" id="28771093"/>
    <dbReference type="InParanoid" id="A0A177CWT1"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF119">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE OXIDOREDUCTASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="3">
        <location>
            <begin position="269"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="570"/>
            <end position="571"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAG11320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="665" mass="74243" checksum="516E403786B6A440" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CWZ6</accession>
    <name>A0A177CWZ6_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CC84DRAFT_40497</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG11568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041933.1">
        <property type="nucleotide sequence ID" value="XM_018186060.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CWZ6"/>
    <dbReference type="STRING" id="1460663.A0A177CWZ6"/>
    <dbReference type="GeneID" id="28769546"/>
    <dbReference type="InParanoid" id="A0A177CWZ6"/>
    <dbReference type="OrthoDB" id="5392779at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47840:SF1">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47840">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="19"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="88"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAG11568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="739" mass="82495" checksum="05CF67DA5472B161" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CXC4</accession>
    <name>A0A177CXC4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">2-oxoisovalerate dehydrogenase subunit alpha</fullName>
            <ecNumber evidence="9">1.2.4.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Branched-chain alpha-keto acid dehydrogenase E1 component alpha chain</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CC84DRAFT_1134625</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>N(6)-[(R)-lipoyl]-L-lysyl-[protein] + 3-methyl-2-oxobutanoate + H(+) = N(6)-[(R)-S(8)-2-methylpropanoyldihydrolipoyl]-L-lysyl-[protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:13457"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:10497"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83142"/>
            <dbReference type="EC" id="1.2.4.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the BCKDHA family.</text>
    </comment>
    <dbReference type="EC" id="1.2.4.4" evidence="9"/>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042570.1">
        <property type="nucleotide sequence ID" value="XM_018176031.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CXC4"/>
    <dbReference type="STRING" id="1460663.A0A177CXC4"/>
    <dbReference type="GeneID" id="28759517"/>
    <dbReference type="InParanoid" id="A0A177CXC4"/>
    <dbReference type="OrthoDB" id="3845at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003863">
        <property type="term" value="F:branched-chain 2-oxo acid dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009083">
        <property type="term" value="P:branched-chain amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02000">
        <property type="entry name" value="TPP_E1_PDC_ADC_BCADC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000015">
        <property type="entry name" value="2-oxoisovalerate dehydrogenase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050771">
        <property type="entry name" value="Alpha-ketoacid_DH_E1_comp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001017">
        <property type="entry name" value="DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43380">
        <property type="entry name" value="2-OXOISOVALERATE DEHYDROGENASE SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43380:SF1">
        <property type="entry name" value="2-OXOISOVALERATE DEHYDROGENASE SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00676">
        <property type="entry name" value="E1_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-0630">Potassium</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Dehydrogenase E1 component" evidence="10">
        <location>
            <begin position="105"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OAG12205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="464" mass="52527" checksum="6D43F66B8FDBA5D1" modified="2016-09-07" version="1">MSLRSVPRRLGARALRRPSICHNASQAAPRVMPKWQTCRNVASTPTAEKVLFPGALNSEFTNSLEFLRPSQNKSISTFRILDQYGQVLDKERGVDTTDEEALELYKHMVCLSIMDLIMFEAQRQGRLSFYMVSTGEEGISVGSASALKPKDTVFCQYREAGVFMQRGFTLDQFMAQLFSNADDFGHGRNMPVHYGSRELNIRTVSSTLATQLPHAAGAAYALKLQNQQNPDIEPRVAVTYFGEGAASEGDFHAALNIAATRQAPCIFICRNNGYAISTPTSDQYRGDGIASRGAGYGMDTIRVDGNDIFAVRTATKEARRLALTDGGRPVLIEMMAYRVGHHSTSDDSYAYRQKVEVEDWKRRDNPITRLRKWLESRDLWNEDKEKETRSQLRKEVLAAFDRGEKKKKPKIRHAFDDVWEEITAEQRAHVEELKDILTRYPKEYDISQYEGGLDSLDELLEKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CXS5</accession>
    <name>A0A177CXS5_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Mediator of RNA polymerase II transcription subunit 7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CC84DRAFT_1192120</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 10">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the Mediator complex subunit 7 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG11650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042015.1">
        <property type="nucleotide sequence ID" value="XM_018181228.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CXS5"/>
    <dbReference type="FunCoup" id="A0A177CXS5">
        <property type="interactions" value="717"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CXS5"/>
    <dbReference type="GeneID" id="28764714"/>
    <dbReference type="InParanoid" id="A0A177CXS5"/>
    <dbReference type="OrthoDB" id="10253553at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070847">
        <property type="term" value="C:core mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1520">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037212">
        <property type="entry name" value="Med7/Med21-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009244">
        <property type="entry name" value="Mediatior_Med7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044888">
        <property type="entry name" value="Mediatior_Med7_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21428">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21428:SF11">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05983">
        <property type="entry name" value="Med7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140718">
        <property type="entry name" value="Mediator hinge subcomplex-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0010">Activator</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 10" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="233"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OAG11650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="266" mass="30317" checksum="106440FFA995A49B" modified="2016-09-07" version="1">MAQPAPEDEDVLTSYFPAPPPFYKHFTPKNLDALSQFKTTHSIDEDAALTTQQLLQLPTELRYLVPPAPPSPSAAYSVFGKKTTLHALEDYPDTMAAIRSRLLTHPVSGDPVLDWTYEQLYPSSPTWSSLDRQAYLFRFLRSIVLSYIELLGIMAHDPTSEAKDEKLKDVLTLALNMHALVNEYRPHQARETLIREMERQVERKRGEVEGVRRMGERVEEVLAGFERSGVEGREEIDGAAGEVSDEERRRERQRETWGVLDEVLGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CYB2</accession>
    <name>A0A177CYB2_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Allergen</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1135339</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042929.1">
        <property type="nucleotide sequence ID" value="XM_018176061.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CYB2"/>
    <dbReference type="GeneID" id="28759547"/>
    <dbReference type="InParanoid" id="A0A177CYB2"/>
    <dbReference type="OrthoDB" id="2118965at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38703:SF1">
        <property type="entry name" value="ALLERGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38703">
        <property type="entry name" value="CHROMOSOME 8, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="250"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="263"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="291"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG12564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="306" mass="33412" checksum="E94508970A4CA1F0" modified="2016-09-07" version="1">MDKAKAAVSDFMSKAGHHDTTVHETVAPAVVEEVVKPHVHEEVNTAIDKEVHQDHYHRTVQPIKDREVLPEKHTAQLGAVQHREFDHRDHDHTKRNLAAEQAQFKDQRVVTETSHSQSANAAIGGEHVHHHIHETIQPVVHKETIQPSVVHTTVPIHEVHHNAATIHESSELPAMTMSEFKQKGGVLSGRDERYDGFEGEPKHIGGTLKHMMEGKTSKRDSHQDHEVRESAMHGDFDPLDGGKHNTAAGRLGGAGTGVGAAGLGRETSSVSSTSHSTGTQPKKASLLDKLNPLKDADGDGKKGLMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CYD3</accession>
    <name>A0A177CYD3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HET-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1053925</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042940.1">
        <property type="nucleotide sequence ID" value="XM_018173517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CYD3"/>
    <dbReference type="STRING" id="1460663.A0A177CYD3"/>
    <dbReference type="GeneID" id="28757003"/>
    <dbReference type="InParanoid" id="A0A177CYD3"/>
    <dbReference type="OrthoDB" id="674604at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF13">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
        <property type="entry name" value="NB-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00364">
        <property type="entry name" value="DISEASERSIST"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="2">
        <location>
            <begin position="28"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="NB-ARC" evidence="1">
        <location>
            <begin position="275"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="697"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG12575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="697" mass="78924" checksum="E577FD6D0516EA6C" modified="2016-09-07" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177D002</accession>
    <name>A0A177D002_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Xanthine/uracil permease family protein-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CC84DRAFT_96892</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family. Azg-like subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042644.1">
        <property type="nucleotide sequence ID" value="XM_018188005.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177D002"/>
    <dbReference type="STRING" id="1460663.A0A177D002"/>
    <dbReference type="GeneID" id="28771491"/>
    <dbReference type="InParanoid" id="A0A177D002"/>
    <dbReference type="OrthoDB" id="431212at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005345">
        <property type="term" value="F:purine nucleobase transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015853">
        <property type="term" value="P:adenine transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015854">
        <property type="term" value="P:guanine transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045018">
        <property type="entry name" value="Azg-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006043">
        <property type="entry name" value="NCS2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43337">
        <property type="entry name" value="XANTHINE/URACIL PERMEASE C887.17-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43337:SF1">
        <property type="entry name" value="XANTHINE_URACIL PERMEASE C887.17-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00860">
        <property type="entry name" value="Xan_ur_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="180"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="244"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="328"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="405"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="456"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="541"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="556"/>
            <end position="576"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAG12279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="576" mass="61946" checksum="99A0D5EB9A0DBF74" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BU81</accession>
    <name>A0A177BU81_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peroxisomal targeting signal receptor</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Peroxin-5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CC84DRAFT_1105053</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peroxisomal targeting signal receptor family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441563">
        <property type="protein sequence ID" value="OAF98983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029349.1">
        <property type="nucleotide sequence ID" value="XM_018175079.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BU81"/>
    <dbReference type="FunCoup" id="A0A177BU81">
        <property type="interactions" value="88"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177BU81"/>
    <dbReference type="GeneID" id="28758565"/>
    <dbReference type="InParanoid" id="A0A177BU81"/>
    <dbReference type="OrthoDB" id="10006023at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005052">
        <property type="term" value="F:peroxisome matrix targeting signal-1 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016560">
        <property type="term" value="P:protein import into peroxisome matrix, docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000218">
        <property type="entry name" value="Peroxisomal targeting signal receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024111">
        <property type="entry name" value="PEX5/PEX5L"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10130:SF0">
        <property type="entry name" value="GH08708P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10130">
        <property type="entry name" value="PEROXISOMAL TARGETING SIGNAL 1 RECEPTOR PEX5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13414">
        <property type="entry name" value="TPR_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="13" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-0675">Receptor</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="12" id="KW-0882">Thioester bond</keyword>
    <keyword evidence="9 15" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <keyword evidence="10" id="KW-0832">Ubl conjugation</keyword>
    <feature type="repeat" description="TPR" evidence="15">
        <location>
            <begin position="360"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="15">
        <location>
            <begin position="512"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="22"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00032505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="OAF98983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="647" mass="70842" checksum="B9742D88E0375070" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BUP8</accession>
    <name>A0A177BUP8_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_1191605</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441564">
        <property type="protein sequence ID" value="OAF98700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029066.1">
        <property type="nucleotide sequence ID" value="XM_018181195.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BUP8"/>
    <dbReference type="STRING" id="1460663.A0A177BUP8"/>
    <dbReference type="GeneID" id="28764681"/>
    <dbReference type="InParanoid" id="A0A177BUP8"/>
    <dbReference type="OrthoDB" id="5294180at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF12">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="25"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAF98700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="655" mass="73032" checksum="D0FF76C405FF9F5C" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BVA3</accession>
    <name>A0A177BVA3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1158649</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441566">
        <property type="protein sequence ID" value="OAF98588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018028954.1">
        <property type="nucleotide sequence ID" value="XM_018177058.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BVA3"/>
    <dbReference type="GeneID" id="28760544"/>
    <dbReference type="InParanoid" id="A0A177BVA3"/>
    <dbReference type="OrthoDB" id="5117488at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAF98588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="209" mass="23274" checksum="A1385EC0EDA4A66B" modified="2016-09-07" version="1">MAPAWLENFITREDATPDPRRNSEQPTLEIHYTAIGGHRRILGVQGDTRPRYEVNRQAILGAWGSKCHITSPANEGKKVAIISFHSLPRAFIEIEFPQRHHQIDISTSKQRFDASGGLGCLHWKGTGMEVCGHASWELRDETSLVMAVDIDQNQVNGVIRLWRQNLDAETVEELVVAAIAKIEEYKLTIRTSKTSFVGATATAGWLASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BVA7</accession>
    <name>A0A177BVA7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1051343</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441575">
        <property type="protein sequence ID" value="OAF98477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018028843.1">
        <property type="nucleotide sequence ID" value="XM_018173483.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BVA7"/>
    <dbReference type="STRING" id="1460663.A0A177BVA7"/>
    <dbReference type="GeneID" id="28756969"/>
    <dbReference type="InParanoid" id="A0A177BVA7"/>
    <dbReference type="OrthoDB" id="1668230at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004713">
        <property type="term" value="F:protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAF98477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="236" mass="26156" checksum="5EA08560F482308A" modified="2016-09-07" version="1" fragment="single">GTAVLALSDDGKRVLKFPLTFETQHCNAQVAARARSHMQESRMMLEREKEIYQHLGLRAGILAPLEISSVGLVFPFFKNGDLRVHLQKTWGEVGQDQLMLWAEEAVERISFTQSMGVYQCDISTRNFLVGDDLSLVLNDFSGSRIGDKAELVGPETSYAKALQEDQYGTVQGSMEGEVFSIGSLLYEILTGQKPYNDLGNSEITDLFQQGSFPPTSTLALGSIIRDCWMGRFSSAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BVL1</accession>
    <name>A0A177BVL1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Integral membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CC84DRAFT_1158339</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the LU7TM family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441564">
        <property type="protein sequence ID" value="OAF98761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029127.1">
        <property type="nucleotide sequence ID" value="XM_018177045.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BVL1"/>
    <dbReference type="FunCoup" id="A0A177BVL1">
        <property type="interactions" value="742"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177BVL1"/>
    <dbReference type="GeneID" id="28760531"/>
    <dbReference type="InParanoid" id="A0A177BVL1"/>
    <dbReference type="OrthoDB" id="19932at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053937">
        <property type="entry name" value="GOST_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009637">
        <property type="entry name" value="GPR107/GPR108-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053938">
        <property type="entry name" value="PTM1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21229:SF1">
        <property type="entry name" value="GH17801P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21229">
        <property type="entry name" value="LUNG SEVEN TRANSMEMBRANE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06814">
        <property type="entry name" value="GOST_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21902">
        <property type="entry name" value="PTM1-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008057402" description="Integral membrane protein" evidence="9">
        <location>
            <begin position="22"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="193"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="225"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="256"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="297"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="328"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="373"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="417"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="domain" description="PTM1-like N-terminal" evidence="11">
        <location>
            <begin position="31"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="GOST seven transmembrane" evidence="10">
        <location>
            <begin position="189"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="466"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="495"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="524"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="537"/>
            <end position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF06814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF21902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OAF98761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="551" mass="62488" checksum="44B3AB4CD78F4AE5" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BVL6</accession>
    <name>A0A177BVL6_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CC84DRAFT_408427</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the phosphatase 2A regulatory subunit B family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441562">
        <property type="protein sequence ID" value="OAF99523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029889.1">
        <property type="nucleotide sequence ID" value="XM_018186079.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BVL6"/>
    <dbReference type="FunCoup" id="A0A177BVL6">
        <property type="interactions" value="635"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177BVL6"/>
    <dbReference type="GeneID" id="28769565"/>
    <dbReference type="InParanoid" id="A0A177BVL6"/>
    <dbReference type="OrthoDB" id="10264446at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005935">
        <property type="term" value="C:cellular bud neck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000159">
        <property type="term" value="C:protein phosphatase type 2A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070199">
        <property type="term" value="P:establishment of protein localization to chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051754">
        <property type="term" value="P:meiotic sister chromatid cohesion, centromeric"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031578">
        <property type="term" value="P:mitotic spindle orientation checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000786">
        <property type="term" value="P:positive regulation of autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031107">
        <property type="term" value="P:septin ring disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031134">
        <property type="term" value="P:sister chromatid biorientation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000016">
        <property type="entry name" value="Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002554">
        <property type="entry name" value="PP2A_B56"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10257">
        <property type="entry name" value="SERINE/THREONINE PROTEIN PHOSPHATASE 2A PP2A REGULATORY SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10257:SF3">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT GAMMA ISOFORM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01603">
        <property type="entry name" value="B56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028043">
        <property type="entry name" value="PP2A_B56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="621"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="48"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="93"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="109"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="632"/>
            <end position="660"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00064351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR028043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAF99523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="668" mass="75325" checksum="01BB35364EF152D6" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BVP7</accession>
    <name>A0A177BVP7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_405521</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441562">
        <property type="protein sequence ID" value="OAF99472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029838.1">
        <property type="nucleotide sequence ID" value="XM_018186062.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BVP7"/>
    <dbReference type="STRING" id="1460663.A0A177BVP7"/>
    <dbReference type="GeneID" id="28769548"/>
    <dbReference type="InParanoid" id="A0A177BVP7"/>
    <dbReference type="OrthoDB" id="2117996at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008057446" evidence="2">
        <location>
            <begin position="17"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="298"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="43"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="298"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="324"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="343"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAF99472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="489" mass="47458" checksum="414DC352040F193F" modified="2016-09-07" version="1">MKYLILSALLASAAIAAPTPANRNQGGNANGGNNANANANSNQAGAGAAKGTAGNTGAAGAAGTAGTAGAATGATGAAGTQGTTGQTGATGQTGATQPAAGTPGTITPGTSSAVPPPPGGAPGQTPTAGDLATAVANWMADTSMVSQFLNSGPTIQDDAAFKQAALVAFNAEVDELTHKAVIDAANGQLPNVQAANSTLATGGAFQDVVDKLQLMSQQGKAAANNIDLINQNRCTNVLPNIDAYMASTGSNSQAVRPNVCDQTGVIGGVQSNGPTLPGQTPGTPQQAFAAAKALASGTGTGQMSQTAGTAGTAANAGAPKTGANGKGTGVNGNQGAGTVANPNVAGGAQGTQAGQTTQGVNTGANTGAQQGTNAGTAAQGTQGTATGAQQGQTGTAAQAQQGANTGAQRQGQTGAAAQAQQGCQHWRSTSGPDRRRCSGTAGCQHWCSATGPGWGRCSGQRQLSISREILRRAWICWQCEVGWKMDLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BWS2</accession>
    <name>A0A177BWS2_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NADH-ubiquinone oxidoreductase 17.8 kDa subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1105370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441563">
        <property type="protein sequence ID" value="OAF99128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029494.1">
        <property type="nucleotide sequence ID" value="XM_018175094.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BWS2"/>
    <dbReference type="STRING" id="1460663.A0A177BWS2"/>
    <dbReference type="GeneID" id="28758580"/>
    <dbReference type="InParanoid" id="A0A177BWS2"/>
    <dbReference type="OrthoDB" id="2120038at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034444">
        <property type="entry name" value="Nuo17.8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42100">
        <property type="entry name" value="OXIDOREDUCTASE 178 KDA SUBUNIT, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G04320)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42100:SF1">
        <property type="entry name" value="OXIDOREDUCTASE 178 KDA SUBUNIT, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G04320)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAF99128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="192" mass="21841" checksum="AE2A3481EAC641DD" modified="2016-09-07" version="1">MQALRRTAATAARKGRTAVPRQQRRYAHDEHHHAHSEPVNESMGLGFWIPIGAIPVFSGLYWISQSDPNAPPIMTRLINKYTETTERYAERNALHVSMVEQAGNDRVLFMKTRPQEHVNMRFPEIMNQGSPYNVPAGQVNNMEKVIEKFKREAYEDNERKHQALADDNIKSEQPWERFPVAPGPAGRGVGAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BWW0</accession>
    <name>A0A177BWW0_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">2,3-bisphosphoglycerate-independent phosphoglycerate mutase</fullName>
            <ecNumber evidence="6">5.4.2.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Cofactor-independent phosphoglycerate mutase homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CC84DRAFT_374233</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2R)-2-phosphoglycerate = (2R)-3-phosphoglycerate</text>
            <dbReference type="Rhea" id="RHEA:15901"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="ChEBI" id="CHEBI:58289"/>
            <dbReference type="EC" id="5.4.2.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 3/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the BPG-independent phosphoglycerate mutase family.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.12" evidence="6"/>
    <dbReference type="EMBL" id="KV441561">
        <property type="protein sequence ID" value="OAF99625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029991.1">
        <property type="nucleotide sequence ID" value="XM_018185959.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BWW0"/>
    <dbReference type="STRING" id="1460663.A0A177BWW0"/>
    <dbReference type="GeneID" id="28769445"/>
    <dbReference type="InParanoid" id="A0A177BWW0"/>
    <dbReference type="OrthoDB" id="1886626at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00186"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004619">
        <property type="term" value="F:phosphoglycerate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006007">
        <property type="term" value="P:glucose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16010">
        <property type="entry name" value="iPGM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1450.10:FF:000001">
        <property type="entry name" value="2,3-bisphosphoglycerate-independent phosphoglycerate mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.720.10:FF:000001">
        <property type="entry name" value="2,3-bisphosphoglycerate-independent phosphoglycerate mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1450.10">
        <property type="entry name" value="BPG-independent phosphoglycerate mutase, domain B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01038">
        <property type="entry name" value="GpmI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011258">
        <property type="entry name" value="BPG-indep_PGM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006124">
        <property type="entry name" value="Metalloenzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036646">
        <property type="entry name" value="PGAM_B_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005995">
        <property type="entry name" value="Pgm_bpd_ind"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01307">
        <property type="entry name" value="pgm_bpd_ind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31637">
        <property type="entry name" value="2,3-BISPHOSPHOGLYCERATE-INDEPENDENT PHOSPHOGLYCERATE MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31637:SF0">
        <property type="entry name" value="2,3-BISPHOSPHOGLYCERATE-INDEPENDENT PHOSPHOGLYCERATE MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06415">
        <property type="entry name" value="iPGM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01676">
        <property type="entry name" value="Metalloenzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001492">
        <property type="entry name" value="IPGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64158">
        <property type="entry name" value="2,3-Bisphosphoglycerate-independent phosphoglycerate mutase, substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9 15" id="KW-0464">Manganese</keyword>
    <keyword evidence="7 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metalloenzyme" evidence="16">
        <location>
            <begin position="7"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="domain" description="BPG-independent PGAM N-terminal" evidence="17">
        <location>
            <begin position="92"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphoserine intermediate" evidence="13">
        <location>
            <position position="72"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="163"/>
            <end position="164"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="267"/>
            <end position="270"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="341"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="408"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="412"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="449"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="450"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="467"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00071648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00083354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001492-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR001492-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR001492-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF01676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF06415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="OAF99625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="520" mass="57202" checksum="8D616296E4536708" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BX93</accession>
    <name>A0A177BX93_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1209906</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441561">
        <property type="protein sequence ID" value="OAF99570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029936.1">
        <property type="nucleotide sequence ID" value="XM_018182249.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BX93"/>
    <dbReference type="GeneID" id="28765735"/>
    <dbReference type="InParanoid" id="A0A177BX93"/>
    <dbReference type="OrthoDB" id="5273928at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="348"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="349"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAF99570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="392" mass="44111" checksum="225AA4BADE45E42D" modified="2016-09-07" version="1">MVRPQRVRAFDEATGQVYEETQVPVTSMVSAWPDKCNGRKTKPQSYRHRGLGASSLYDMAMRSCAWHINLFMPSDLQSAEWHFAHRIYEHLQKNQNLTANAWSLFQQAFPGEAELNRTYPIRIPALYGQSASELPSIQQWLRLLPFSHLLLLNIQCLCLRLDDLITLTTLPNLGVLLMRFAYDKLPQELDDKAMRDWSRAVKEKGAFTQLRVVGLHHHAASLPATLKGLSQFPALRICTVEPQPPLASSQAAISQIASAALPFELLVDDYTGTADSDTPEAVWSKGNLPGHVKMKMLYDLAGRMHPDQAPEDVPDSAVLSVYYGAERNLAYNRYPLWFKRLGSVETEYEAGRQPKRYQDDQGGEERTGGGKKPRRLREGKQMDIGSLLGGFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2023-06-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BX97</accession>
    <name>A0A177BX97_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1169728</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441563">
        <property type="protein sequence ID" value="OAF99006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029372.1">
        <property type="nucleotide sequence ID" value="XM_018179740.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BX97"/>
    <dbReference type="GeneID" id="28763226"/>
    <dbReference type="InParanoid" id="A0A177BX97"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAF99006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="90" mass="9609" checksum="2EAE9B910C3DDF53" modified="2016-09-07" version="1">MTRACPTHGRAVVAPTLCRPLEGFANLAALISQSCWLTALAFSEISRGEVLAPTQAEVRSSDHDPGHSAGLRIVVEFSTFVEVVVVILSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BXI6</accession>
    <name>A0A177BXI6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">DUF914-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CC84DRAFT_1191205</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC35F solute transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441562">
        <property type="protein sequence ID" value="OAF99227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029593.1">
        <property type="nucleotide sequence ID" value="XM_018181171.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BXI6"/>
    <dbReference type="STRING" id="1460663.A0A177BXI6"/>
    <dbReference type="GeneID" id="28764657"/>
    <dbReference type="InParanoid" id="A0A177BXI6"/>
    <dbReference type="OrthoDB" id="429955at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009262">
        <property type="entry name" value="SLC35_F1/F2/F6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052221">
        <property type="entry name" value="SLC35F_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14233">
        <property type="entry name" value="DUF914-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14233:SF4">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER F2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06027">
        <property type="entry name" value="SLC35F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="57"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="126"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="152"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="179"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="217"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="243"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="284"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="307"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="333"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAF99227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="389" mass="42980" checksum="7BD3EBA0C3ECD762" modified="2016-09-07" version="1">MTPTDTIAHQPKGVDTTGPENGTGVPTLVASHEANPVLERDAATKGSWMAYVKTKQFWIAMVLGQTLAICITSTNTLSQLLSNEGTSIPAFQSLFNYILLNIVYTGYTLYKLGLKGWAKMVVKDGWRFFILAFIDVLGNYFIVLAYRYTTILSAQLINFWAIVVVVILSFLFLKVRYRWTQIAGILLCVGGVGVLFGSDHITGFNQYDALDAVKGDLFALLGASLYGVSNTFEEFLVSEEPLYVVIGQLGFWGMFINGTVAGIFDRSSFRAAVWNADVGGYLTGYTLILSLFYSLAPILFRLTSAAFFNISLLTGNFWGVAIGVKVFHYHIHWMYPIAFVLILVGQIIYFLRQGSLAEQKKPWLGEAQDKGVSGIGTAKRRVENPDAIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BYM7</accession>
    <name>A0A177BYM7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1222805</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441561">
        <property type="protein sequence ID" value="OAF99798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030164.1">
        <property type="nucleotide sequence ID" value="XM_018183418.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BYM7"/>
    <dbReference type="GeneID" id="28766904"/>
    <dbReference type="InParanoid" id="A0A177BYM7"/>
    <dbReference type="OrthoDB" id="3767041at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="260"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="265"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAF99798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="284" mass="32013" checksum="BB90549B5BB540FB" modified="2016-09-07" version="1">MVINETQLDKRRRQNRDSQRRFTVGERNKSRRSNSWGNPTGNHGQQLAALDELSASLGSNSSSLSSEHPNTFISNDYQSLLSPQGCSEGYNNWSSNKGQSNTRGEVLYRHGPPTNDSNPLPSGQMSLPPLNEQFPLHGIPMNVEHANTGRQQEQQPHNIGDTRASRKDGMLSPVSLLDVDKRIGSEVSKPFRPQELFFQHPGQRVRRRSESRAEQMIADVEKLYEFGISLSLFPEDLLLRNSLRRMKERFQSLVVLGDVSSSEGDLYDGDPADRDSDDEQEYGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BYN1</accession>
    <name>A0A177BYN1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Non-structural maintenance of chromosomes element 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CC84DRAFT_1169550</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the SMC5-SMC6 complex, that promotes sister chromatid alignment after DNA damage and facilitates double-stranded DNA breaks (DSBs) repair via homologous recombination between sister chromatids.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the SMC5-SMC6 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the NSE4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441562">
        <property type="protein sequence ID" value="OAF99449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029815.1">
        <property type="nucleotide sequence ID" value="XM_018179689.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BYN1"/>
    <dbReference type="STRING" id="1460663.A0A177BYN1"/>
    <dbReference type="GeneID" id="28763175"/>
    <dbReference type="InParanoid" id="A0A177BYN1"/>
    <dbReference type="OrthoDB" id="361242at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030915">
        <property type="term" value="C:Smc5-Smc6 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027786">
        <property type="entry name" value="Nse4/EID"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014854">
        <property type="entry name" value="Nse4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029225">
        <property type="entry name" value="Nse4_Nse3-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16140">
        <property type="entry name" value="NON-STRUCTURAL MAINTENANCE OF CHROMOSOMES ELEMENT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16140:SF0">
        <property type="entry name" value="NON-STRUCTURAL MAINTENANCE OF CHROMOSOMES ELEMENT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15412">
        <property type="entry name" value="Nse4-Nse3_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08743">
        <property type="entry name" value="Nse4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4 7" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="5 7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nse4/EID protein Nse3/MAGE-binding" evidence="10">
        <location>
            <begin position="239"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="Non-structural maintenance of chromosome element 4 C-terminal" evidence="9">
        <location>
            <begin position="444"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="147"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="283"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="354"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="35"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="147"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="305"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="361"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="372"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF15412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OAF99449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="549" mass="61370" checksum="E0400DA6488F830D" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2023-06-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BZL6</accession>
    <name>A0A177BZL6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_357355</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441560">
        <property type="protein sequence ID" value="OAG00032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030397.1">
        <property type="nucleotide sequence ID" value="XM_018185888.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BZL6"/>
    <dbReference type="GeneID" id="28769374"/>
    <dbReference type="InParanoid" id="A0A177BZL6"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG00032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="136" mass="15317" checksum="2A012FBDA9A7C8AA" modified="2016-09-07" version="1">MQPALPPRDGGCSRRLSRGVNCFTEQLWSSAPKAVGRNLGRHAHSSPLTCSISSFINCKISTVMLHFLLFSSLVGYAWAKTVTYDWYIRWRLVRCVFTTPRSSLTSARQRQTVSLDLSSVSMGYGRRRALIPRCNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BZM0</accession>
    <name>A0A177BZM0_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Endoplasmic reticulum chaperone BiP</fullName>
            <ecNumber evidence="4">3.6.4.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Immunoglobulin heavy chain-binding protein homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CC84DRAFT_1103118</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER. Is required for secretory polypeptide translocation. May physically associate with SEC63 protein in the endoplasmic reticulum and this interaction may be regulated by ATP hydrolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.10" evidence="4"/>
    <dbReference type="EMBL" id="KV441560">
        <property type="protein sequence ID" value="OAF99886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030252.1">
        <property type="nucleotide sequence ID" value="XM_018174997.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BZM0"/>
    <dbReference type="FunCoup" id="A0A177BZM0">
        <property type="interactions" value="1233"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177BZM0"/>
    <dbReference type="GeneID" id="28758483"/>
    <dbReference type="InParanoid" id="A0A177BZM0"/>
    <dbReference type="OrthoDB" id="2401965at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006986">
        <property type="term" value="P:response to unfolded protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd10241">
        <property type="entry name" value="ASKHA_NBD_HSP70_BiP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.10:FF:000009">
        <property type="entry name" value="DnaK-type molecular chaperone BiP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000153">
        <property type="entry name" value="Endoplasmic reticulum chaperone BiP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.34.10:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000172">
        <property type="entry name" value="Heat shock 70 kDa protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.30:FF:000001">
        <property type="entry name" value="heat shock 70 kDa protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000026">
        <property type="entry name" value="Heat shock protein 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042050">
        <property type="entry name" value="BIP_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001413">
        <property type="entry name" value="PRK00290.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="HEAT SHOCK PROTEIN 70KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 15" id="KW-0732">Signal</keyword>
    <keyword evidence="10 16" id="KW-0346">Stress response</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008057536" description="Endoplasmic reticulum chaperone BiP" evidence="15">
        <location>
            <begin position="37"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="558"/>
            <end position="585"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OAF99886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="675" mass="74081" checksum="33D0B32B89CA6C69" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C0J1</accession>
    <name>A0A177C0J1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">AAT family amino acid transporter, variant</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CC84DRAFT_1222521</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441560">
        <property type="protein sequence ID" value="OAG00227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030592.1">
        <property type="nucleotide sequence ID" value="XM_018183382.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C0J1"/>
    <dbReference type="STRING" id="1460663.A0A177C0J1"/>
    <dbReference type="GeneID" id="28766868"/>
    <dbReference type="InParanoid" id="A0A177C0J1"/>
    <dbReference type="OrthoDB" id="3900342at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000001">
        <property type="entry name" value="Amino acid permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF26">
        <property type="entry name" value="GENERAL AMINO ACID PERMEASE AGP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="84"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="135"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="168"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="201"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="243"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="281"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="333"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="374"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="405"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="447"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="481"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="8">
        <location>
            <begin position="56"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAG00227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="546" mass="60878" checksum="63E8986B40A6F0FF" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C136</accession>
    <name>A0A177C136_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1168279</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441558">
        <property type="protein sequence ID" value="OAG01136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031501.1">
        <property type="nucleotide sequence ID" value="XM_018179360.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C136"/>
    <dbReference type="GeneID" id="28762846"/>
    <dbReference type="InParanoid" id="A0A177C136"/>
    <dbReference type="OrthoDB" id="10300294at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG01136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="84" mass="8949" checksum="7268FD62A2932D37" modified="2016-09-07" version="1">MKIECFGLLLLSGIVCDLESVIPSLNGRNMDPSMGQRIAPAVVCILRAVIAFLCGTEGCTPTEAKGLSHVAQVRYTGSHCKARE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C1B6</accession>
    <name>A0A177C1B6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_1228506</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441557">
        <property type="protein sequence ID" value="OAG01433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031798.1">
        <property type="nucleotide sequence ID" value="XM_018183643.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C1B6"/>
    <dbReference type="STRING" id="1460663.A0A177C1B6"/>
    <dbReference type="GeneID" id="28767129"/>
    <dbReference type="InParanoid" id="A0A177C1B6"/>
    <dbReference type="OrthoDB" id="1103324at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF6">
        <property type="entry name" value="CYTOCHROME P450 2C30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0349">Heme</keyword>
    <keyword evidence="4 5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="291"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="445"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAG01433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="542" mass="62970" checksum="606E4BED33BDEF3A" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C219</accession>
    <name>A0A177C219_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Delta(14)-sterol reductase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">C-14 sterol reductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Sterol C14-reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CC84DRAFT_1221187</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the ERG4/ERG24 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441557">
        <property type="protein sequence ID" value="OAG01703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032068.1">
        <property type="nucleotide sequence ID" value="XM_018183239.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C219"/>
    <dbReference type="FunCoup" id="A0A177C219">
        <property type="interactions" value="491"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177C219"/>
    <dbReference type="GeneID" id="28766725"/>
    <dbReference type="InParanoid" id="A0A177C219"/>
    <dbReference type="OrthoDB" id="10262235at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050613">
        <property type="term" value="F:Delta14-sterol reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001171">
        <property type="entry name" value="ERG24_DHCR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018083">
        <property type="entry name" value="Sterol_reductase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21257">
        <property type="entry name" value="DELTA(14)-STEROL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21257:SF52">
        <property type="entry name" value="DELTA(14)-STEROL REDUCTASE TM7SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01222">
        <property type="entry name" value="ERG4_ERG24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01017">
        <property type="entry name" value="STEROL_REDUCT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01018">
        <property type="entry name" value="STEROL_REDUCT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 13" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9 13" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="12 13" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="8 13" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="11 13" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="77"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="154"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="290"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="320"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="440"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU369120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OAG01703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="492" mass="56017" checksum="6ADA1A63BF35BC9E" modified="2016-09-07" version="1">MASKRKTDPPSEKSHGYEFFGPPGAFAISFFLPILCYAFTFLCNDISGCPAPSLLHPSTLDFEQLKKEVGWPGFSGLITWNAVLGNFAYYLLSLALYAFLPAEEPEGTELRTGGRLKYRFNAWSSGIFILVILAAGTAVEGAEFPVWTFISDNYVGLLTTNILTSYALATYVYILSFTVQHPKDPSLRELAMGGHSGNILYDWFIGRELNPRITLPIFGEIDIKTWAEIRPGMLGWVILDLAFIMQQYRNFGKVTDSIILVTFAQAFYVFDCYYMEPAMLTTIDIISDGFGLMLAFGDLVWVPFTYSLQARYLATYPVELGIKGLVPIFAVQAVGYYIFRSVNNEKNRFRTNPDDPRVKHLKYIETASGSKLLITGWWGTARHINYLGDWFMSWSYVLPTAAAGYVIRNAATHPLDATSKDAVFFQNTYQKYVVPGEAKGWGMIVTYFFMVYFAVLLIHRERRDEEKCKKKYGKDWERYCELVPYRIIPYVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C223</accession>
    <name>A0A177C223_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1263014</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441558">
        <property type="protein sequence ID" value="OAG00939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031304.1">
        <property type="nucleotide sequence ID" value="XM_018185198.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C223"/>
    <dbReference type="GeneID" id="28768684"/>
    <dbReference type="InParanoid" id="A0A177C223"/>
    <dbReference type="OrthoDB" id="3755269at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG00939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="128" mass="13199" checksum="37293D105AAE8448" modified="2016-09-07" version="1">MRPLAILSPTLAIAVPASNKDTPAAVIARFTHSDECQLPSAPATCAGSSQKDVIVHYGKNTTQAEKDLLLNAAKASGASIHEAMNNFGFTGFVPESVVELIAAHGKTCGVSVYENGCAGIPWCGEAPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2023-06-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C265</accession>
    <name>A0A177C265_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_216454</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441557">
        <property type="protein sequence ID" value="OAG01743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032108.1">
        <property type="nucleotide sequence ID" value="XM_018185613.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C265"/>
    <dbReference type="GeneID" id="28769099"/>
    <dbReference type="InParanoid" id="A0A177C265"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG01743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="105" mass="11193" checksum="0B2418DB24DD2120" modified="2016-09-07" version="1">MGLGLMEAINSGLRASQAYLPRSTSSQLENSKLPVVEMTGNGLISALLRSHDRSGRVTIFHATSENAANIIATPMRDSAIARCTTFTGSGTTDRGNQLFNTTHIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C279</accession>
    <name>A0A177C279_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1180708</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441559">
        <property type="protein sequence ID" value="OAG00740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031105.1">
        <property type="nucleotide sequence ID" value="XM_018180501.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C279"/>
    <dbReference type="GeneID" id="28763987"/>
    <dbReference type="InParanoid" id="A0A177C279"/>
    <dbReference type="OrthoDB" id="3918601at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38794">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38794:SF1">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG00740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="116" mass="12560" checksum="F57B6724D433CF71" modified="2016-09-07" version="1">MSLEPTASPVLFTPSHPWVVENDYTSLLNVVGWFGITVIVLTVFTRLGTRQAISRTVGFDDIAIVIATFISIGETVAMSIGVKNGLGCLTGKETVEQLDAQQKASHSYHLLVVYCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C2I1</accession>
    <name>A0A177C2I1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1228381</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441557">
        <property type="protein sequence ID" value="OAG01361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031726.1">
        <property type="nucleotide sequence ID" value="XM_018183635.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C2I1"/>
    <dbReference type="GeneID" id="28767121"/>
    <dbReference type="InParanoid" id="A0A177C2I1"/>
    <dbReference type="OrthoDB" id="2151789at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG01361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="120" mass="13708" checksum="98BF14C5D606907A" modified="2016-09-07" version="1">MLHSSTVTPRQCFITSLPSDSFLGLLIKLGLSTLQETARLYAIMLADIRAKASGSWRISCVHPIRSTLWAANSTARGGHVLGLERYYENFDMYKFTFRSQRRRTLPHPGPRVNQRHPQFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C2J1</accession>
    <name>A0A177C2J1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_273594</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441558">
        <property type="protein sequence ID" value="OAG00957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031322.1">
        <property type="nucleotide sequence ID" value="XM_018185700.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C2J1"/>
    <dbReference type="GeneID" id="28769186"/>
    <dbReference type="InParanoid" id="A0A177C2J1"/>
    <dbReference type="OrthoDB" id="10537326at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG00957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="156" mass="17317" checksum="AEE40994B1C7B66B" modified="2016-09-07" version="1">MEIGRRGARQCVEQSESERQSRLVQPTRQHKARPVALIRFLTCSSSARNRDNPGEERCGIIGGPFAETLIDRLSDNVTGRPQHPRFLAQKVARGCSQAPLSIPVSRDPSAVTCDSCVFLQLHQATALPDARRRRMTRPLPCTAQQQLPSLHATHTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C2J4</accession>
    <name>A0A177C2J4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Mitochondrial import inner membrane translocase subunit TIM23</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CC84DRAFT_190328</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the TIM23 complex, at least composed of TIM23, TIM17, TIM50 and TIM21.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Mitochondrion inner membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the Tim17/Tim22/Tim23 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441557">
        <property type="protein sequence ID" value="OAG01371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031736.1">
        <property type="nucleotide sequence ID" value="XM_018185529.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C2J4"/>
    <dbReference type="FunCoup" id="A0A177C2J4">
        <property type="interactions" value="537"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177C2J4"/>
    <dbReference type="GeneID" id="28769015"/>
    <dbReference type="InParanoid" id="A0A177C2J4"/>
    <dbReference type="OrthoDB" id="159299at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005744">
        <property type="term" value="C:TIM23 mitochondrial import inner membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030943">
        <property type="term" value="F:mitochondrion targeting sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005681">
        <property type="entry name" value="Tim23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045238">
        <property type="entry name" value="Tim23-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00983">
        <property type="entry name" value="3a0801s02tim23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15371:SF0">
        <property type="entry name" value="SD19278P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15371">
        <property type="entry name" value="TIM23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02466">
        <property type="entry name" value="Tim17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="9"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAG01371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="218" mass="23080" checksum="9DB9481D54F40AB8" modified="2016-09-07" version="1">MTIWDTLTGRKSASTQTATPAAEPHDNFSPAPFDPSTAIQQPSDFILDPTQLHPLAGLNQDTLDYLQLEDSVLSDLPGSQSALPSRGWSDDLCYGTGISYLSALTVGGAWGLAEGLQKNPASMPPRLRINGVLNAVTRRGPFLGNSAGVVAMVYNGINSTIGYYRGKHDMTNSVLAGALSGAIFKSTRGVRPMAISSGIVASVAGSWALFRKVYFESE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C4G3</accession>
    <name>A0A177C4G3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CC84DRAFT_1153865</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441557">
        <property type="protein sequence ID" value="OAG01772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032137.1">
        <property type="nucleotide sequence ID" value="XM_018176857.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C4G3"/>
    <dbReference type="GeneID" id="28760343"/>
    <dbReference type="InParanoid" id="A0A177C4G3"/>
    <dbReference type="OrthoDB" id="6509908at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF234">
        <property type="entry name" value="MFS-TYPE TRANSPORTER DBAD-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="112"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="143"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="201"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="242"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="277"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="307"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="333"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="370"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="402"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="4">
        <location>
            <begin position="42"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAG01772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="436" mass="47657" checksum="FC640B429FF71979" modified="2016-09-07" version="1">MQDSEKKENALGYSIDVSVGGSQDSIQTVQKEPIVRQDGGTRAWLQVMGCWLLFMNTWGLTNSFSIFETYYNQKFQHISHSNISWIGSMQLFLTLFVGVFAGWLLDRGHLRIVLVTGIAFEVVGIAMTSLCTTYWHLLLAQGVCVGIGSGTLAFTSAAIIPFYFAKRRMLAAGIVSTGSSVAGVVYPLMMRELFDKVGFAWAVRVLALVMLGGLSMSLVILRPHSSARKERALLRSDLLRDAPYTIFIVSYAFMVAGVYVPYFFIQSYALDLSIDESMTFNVVAIMNAATFFGRFPYNYLADIYGGIAVLVPCCFATSIILFFWRFVHTLGGLIAISATFCFVTGGLVSLPAVTIANLTEDKSEYGTRMGMGYTIAAIGALLGNPIAGLARDSDSIDVLERWQGAWFVAGGALLVATALMIWARVLRAGVNMSVKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C526</accession>
    <name>A0A177C526_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_910854</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG02723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033088.1">
        <property type="nucleotide sequence ID" value="XM_018187872.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C526"/>
    <dbReference type="GeneID" id="28771358"/>
    <dbReference type="InParanoid" id="A0A177C526"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG02723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="139" mass="15423" checksum="8F14862F5AF56128" modified="2016-09-07" version="1">MLMFSKNLSKMAGASRQLLAFARDRGLPSSSWMSLVLRISACLSTPSLFPPRFHAFFIALTSGLPPFGTLSCLLVLALVTSNMISIGFIIWRRTKKLPLLPSHSASYTALDSPWMDLHSAFVCRCLSLLSSRLYRTLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C6F8</accession>
    <name>A0A177C6F8_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">WW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1097643</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG03115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033480.1">
        <property type="nucleotide sequence ID" value="XM_018174726.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C6F8"/>
    <dbReference type="GeneID" id="28758212"/>
    <dbReference type="InParanoid" id="A0A177C6F8"/>
    <dbReference type="OrthoDB" id="2367685at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="12"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="275"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="20"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="120"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="145"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG03115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="304" mass="34696" checksum="A943D8B77938A8B4" modified="2016-09-07" version="1">MGLLNNLVDQFTHQGAHGHSQGQGYGQSPYSQQPYGQQPYGQQNGQQQSGGYPRPSYMNDRPNPPEPWITEWDLSANTWVFINRQTGQRTHEFPRGGGNWYPPPAHGYGAGGGAYPPPQQGYSPGQGDYPPGSQGYGLQEGYGGPPQQQQYQQPPSQQKKDHSGRNTALGVMAGIAGGALLVHEGHKVEEKWDEDKYRAEERFDEEKYRVEDRFEEDKYRAEDRFDDDRYRMEERLEDFPDDAARWTGRKVREVEDIPADVAGWVGRKEGDVERFGDGIEDAYDDGRDEARYEDDDDRRDNDRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C788</accession>
    <name>A0A177C788_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glycoside hydrolase 131 catalytic N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1122999</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG03614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033979.1">
        <property type="nucleotide sequence ID" value="XM_018175645.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C788"/>
    <dbReference type="STRING" id="1460663.A0A177C788"/>
    <dbReference type="GeneID" id="28759131"/>
    <dbReference type="InParanoid" id="A0A177C788"/>
    <dbReference type="OrthoDB" id="120072at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041524">
        <property type="entry name" value="GH131_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34612">
        <property type="entry name" value="GH131_N DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34612:SF6">
        <property type="entry name" value="GLYCOSIDE HYDROLASE 131 CATALYTIC N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18271">
        <property type="entry name" value="GH131_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008057841" description="Glycoside hydrolase 131 catalytic N-terminal domain-containing protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase 131 catalytic N-terminal" evidence="2">
        <location>
            <begin position="20"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG03614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="261" mass="28514" checksum="7457A300CF902D89" modified="2016-09-07" version="1" fragment="single">MFGKAALVSALVSAVSAGTILWDGRFNEFTSSADLNKWSWANQVGPYQYYIHGSGAVTKYVNLSPSYKNPADAGSKQGAKITIDNTAKWNSDMWRTELIPQTKAAINSGKVYYHFSIKRSTTNVPSATNEHQIAFFESHFTELKYGWVNGESGTSNTNLQWFVGGQSKWKVELVADVWHNVAYEIDFSANQVTFWHSTGSDALTKTAGPFSTSTSSNGADWHLGVLRLPRSGNDGTGAEDWYFSGTYVESGSLTTSVSSPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C7H6</accession>
    <name>A0A177C7H6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PIN domain-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_1125262</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG03081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033446.1">
        <property type="nucleotide sequence ID" value="XM_018175715.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C7H6"/>
    <dbReference type="STRING" id="1460663.A0A177C7H6"/>
    <dbReference type="GeneID" id="28759201"/>
    <dbReference type="InParanoid" id="A0A177C7H6"/>
    <dbReference type="OrthoDB" id="2959108at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd09870">
        <property type="entry name" value="PIN_YEN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006086">
        <property type="entry name" value="XPG-I_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006084">
        <property type="entry name" value="XPG/Rad2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006085">
        <property type="entry name" value="XPG_DNA_repair_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081">
        <property type="entry name" value="FLAP ENDONUCLEASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081:SF62">
        <property type="entry name" value="XPG-I DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00867">
        <property type="entry name" value="XPG_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00752">
        <property type="entry name" value="XPG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00853">
        <property type="entry name" value="XPGRADSUPER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00484">
        <property type="entry name" value="XPGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XPG-I" evidence="3">
        <location>
            <begin position="120"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAG03081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="436" mass="49868" checksum="B5308F033EB38D6C" modified="2016-09-07" version="1" fragment="single">MGITALWDVIKAEDHSVPIAQLAEAHFKKHERPLRIAVDEADWRFNNLTAQQVYMIRETSNEPAFQGIEKSMFYRICRLLTLNVQLLFVFDGPGRPWKRGRRGQGRINYEERRLLKELLNYLRIPHHEAPGEAEAECARLQQLGVVDAVFSQDSDTLMFGCSMLVRDDRVAKEKGNNNRSKENTKKSGTSVRVIYGQEIQQRHRFDREGLVLFAMLSGGDYDITGLRNCGSAMAAGAVRAGLGTSLCQCRTKTHCVLWRSELSAYFQTQRGRKPEIPADFPDIKTLDKYNRPKISTDDQLRNLRGLRHGWNVPIDEMKLLELTSSRFNIWGKLYMNWVGPVLLTKYLVSRDLTLPKENVHQIKITKQGAKKDIVQNVAPPLLKSLAFSPFTLTTLIQKDFEGDRAGYWTSKMQDPFEPDCTVKADIPVYLLERVLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C7T4</accession>
    <name>A0A177C7T4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CC84DRAFT_1097224</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG02912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033277.1">
        <property type="nucleotide sequence ID" value="XM_018174700.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C7T4"/>
    <dbReference type="STRING" id="1460663.A0A177C7T4"/>
    <dbReference type="GeneID" id="28758186"/>
    <dbReference type="InParanoid" id="A0A177C7T4"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051000">
        <property type="entry name" value="Homeobox_DNA-bind_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057939">
        <property type="entry name" value="TRF2_HOY1_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24324:SF5">
        <property type="entry name" value="HEMATOPOIETICALLY-EXPRESSED HOMEOBOX PROTEIN HHEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24324">
        <property type="entry name" value="HOMEOBOX PROTEIN HHEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24818">
        <property type="entry name" value="PH_TRF2_HOY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 5 6" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4 5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="8">
        <location>
            <begin position="29"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="5">
        <location>
            <begin position="31"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAG02912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="570" mass="62442" checksum="8C981756F9794A85" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C8H3</accession>
    <name>A0A177C8H3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_961446</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG03162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033527.1">
        <property type="nucleotide sequence ID" value="XM_018187965.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C8H3"/>
    <dbReference type="FunCoup" id="A0A177C8H3">
        <property type="interactions" value="1271"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177C8H3"/>
    <dbReference type="GeneID" id="28771451"/>
    <dbReference type="InParanoid" id="A0A177C8H3"/>
    <dbReference type="OrthoDB" id="4337792at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051430">
        <property type="entry name" value="Fungal_TF_Env_Response"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31944">
        <property type="entry name" value="HEME-RESPONSIVE ZINC FINGER TRANSCRIPTION FACTOR HAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31944:SF131">
        <property type="entry name" value="HEME-RESPONSIVE ZINC FINGER TRANSCRIPTION FACTOR HAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="16"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAG03162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="740" mass="83538" checksum="4C516F1A8A92C3EA" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C8P5</accession>
    <name>A0A177C8P5_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CC84DRAFT_1197246</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG03501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033866.1">
        <property type="nucleotide sequence ID" value="XM_018181511.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C8P5"/>
    <dbReference type="STRING" id="1460663.A0A177C8P5"/>
    <dbReference type="GeneID" id="28764997"/>
    <dbReference type="InParanoid" id="A0A177C8P5"/>
    <dbReference type="OrthoDB" id="5290825at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015798">
        <property type="term" value="P:myo-inositol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015791">
        <property type="term" value="P:polyol transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000100">
        <property type="entry name" value="MFS sugar transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050814">
        <property type="entry name" value="Myo-inositol_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020:SF26">
        <property type="entry name" value="MYO-INOSITOL TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G01560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020">
        <property type="entry name" value="PROTON MYO-INOSITOL COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="128"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="200"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="263"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="385"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="416"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="446"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="479"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="518"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="550"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="133"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="624"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="17"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OAG03501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="643" mass="72999" checksum="F1B4387CFE3B6F43" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C8T3</accession>
    <name>A0A177C8T3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Myb-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1178680</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG03167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033532.1">
        <property type="nucleotide sequence ID" value="XM_018180363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C8T3"/>
    <dbReference type="GeneID" id="28763849"/>
    <dbReference type="InParanoid" id="A0A177C8T3"/>
    <dbReference type="OrthoDB" id="3778650at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb-like" evidence="2">
        <location>
            <begin position="253"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="2">
        <location>
            <begin position="428"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="315"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="315"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="331"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG03167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="486" mass="54600" checksum="67722524B1721710" modified="2016-09-07" version="1">MVASPMSASMRAHDSFSTNGMGPNVAQILQQMNIKGFHDFLVGRLLYLSQEAHWRLKSDLDLRGWPLHLRSMDDASWQLEAGAPWAPEDQKSLMVLSAHGVKAEDIAEQFFEGRTVDECQVEIDAIKAGVPMNSIETGQGAADIDIGASKAASPETPSTKAILSGLAKTPWKPTSFINRLIEVSSGAARARSDTPHADSRKDWNQADRDTVWAAVQRGMSPRQIQEKYLPFRSESAIQTRMTKERKLRGVQAIPTKWSNRDNELVIKLVDEGHDFEDIAPRLSRERTPKQIEARYRNLKKQARVSRMSVEVNVIDDDEDVELGDDNMQVDADGDEGSEYNDEISRVVQTPHKPKTTRKTIPYNSSEKSPTKKPPSSITSIRTKLLNSIDAKYLDSDGKKGLRKALNKTGWPTRFTSVEEHDSPMPEKNGPKWPTKDVEALRCIRETASSIPYKKLEEFFPGRSQTAIRNIYNTRANPSPNYSDRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C8T4</accession>
    <name>A0A177C8T4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Di-copper centre-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CC84DRAFT_1188539</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG04053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034418.1">
        <property type="nucleotide sequence ID" value="XM_018180995.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C8T4"/>
    <dbReference type="STRING" id="1460663.A0A177C8T4"/>
    <dbReference type="GeneID" id="28764481"/>
    <dbReference type="InParanoid" id="A0A177C8T4"/>
    <dbReference type="OrthoDB" id="6132182at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1280.10">
        <property type="entry name" value="Di-copper center containing domain from catechol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008922">
        <property type="entry name" value="Di-copper_centre_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050316">
        <property type="entry name" value="Tyrosinase/Hemocyanin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002227">
        <property type="entry name" value="Tyrosinase_Cu-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474">
        <property type="entry name" value="TYROSINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474:SF126">
        <property type="entry name" value="TYROSINASE-LIKE PROTEIN TYR-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00264">
        <property type="entry name" value="Tyrosinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00092">
        <property type="entry name" value="TYROSINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48056">
        <property type="entry name" value="Di-copper centre-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00497">
        <property type="entry name" value="TYROSINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00498">
        <property type="entry name" value="TYROSINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0186">Copper</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008057839" evidence="3">
        <location>
            <begin position="22"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosinase copper-binding" evidence="4">
        <location>
            <begin position="93"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosinase copper-binding" evidence="5">
        <location>
            <begin position="270"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAG04053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="347" mass="37859" checksum="2353D4B4D65FC222" modified="2016-09-07" version="1">MYFASLLRALAVLSTIQTTLGTPINDPVNVPPASCNNPPIRQEWRQLTNAQKKAYTDAVLCLTTKPAISGLQGTTNRFDDHQAVHSAQTPNIHWVGHFILWHRYFVATFERALRESCAYTGAQPYWDWSLDAEPSNLSSTRPFETAIFDPRTGFGGNGPKVEPTPEQNPLNITGGTGGGCVPSGPFAAPNFWVNIPARDCLRRDFIPWIMNSFADPALVANVLAQPDYTSFARAIEGTPSFAATNIHGSGHFGVGGVLGQLGNAANSPADPLFYLHHGNLDHVLWKWQQQDLAIRLKEVGGPVTPFDYGGVNVTLDFKINMGTLAGDATLKDLLDTEGKTLCYTYDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C8T8</accession>
    <name>A0A177C8T8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HET-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_964072</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG03272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033637.1">
        <property type="nucleotide sequence ID" value="XM_018187988.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C8T8"/>
    <dbReference type="STRING" id="1460663.A0A177C8T8"/>
    <dbReference type="GeneID" id="28771474"/>
    <dbReference type="InParanoid" id="A0A177C8T8"/>
    <dbReference type="OrthoDB" id="4850726at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF64">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="105"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG03272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="572" mass="65122" checksum="171573650F9F418B" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C995</accession>
    <name>A0A177C995_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CC84DRAFT_1220197</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG03327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033692.1">
        <property type="nucleotide sequence ID" value="XM_018183142.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C995"/>
    <dbReference type="STRING" id="1460663.A0A177C995"/>
    <dbReference type="GeneID" id="28766628"/>
    <dbReference type="InParanoid" id="A0A177C995"/>
    <dbReference type="OrthoDB" id="429813at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007817">
        <property type="entry name" value="Isocyanide_synthase_DIT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37285">
        <property type="entry name" value="SPORE WALL MATURATION PROTEIN DIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37285:SF5">
        <property type="entry name" value="SPORE WALL MATURATION PROTEIN DIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05141">
        <property type="entry name" value="DIT1_PvcA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="426"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="29"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="30"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAG03327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="787" mass="86768" checksum="E6AD2FAE0C644FF8" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C9V2</accession>
    <name>A0A177C9V2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1165729</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG03500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033865.1">
        <property type="nucleotide sequence ID" value="XM_018178784.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C9V2"/>
    <dbReference type="STRING" id="1460663.A0A177C9V2"/>
    <dbReference type="GeneID" id="28762270"/>
    <dbReference type="InParanoid" id="A0A177C9V2"/>
    <dbReference type="OrthoDB" id="10029320at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF222">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE STCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="1">
        <location>
            <position position="316"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG03500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="401" mass="45007" checksum="36BACF56C476E074" modified="2016-09-07" version="1">MAPGHLLNLVDAILDKTETFINLIEEKAKTGEEIRLEEYTTNLVFDIIGIVTFNMDLNAQIEGKQSDVLLTYRALSQVFNKRPFGAVWWKEYFTKNEREIRRLDKKLDGILKEEIRRQHKEILAGADPTSRSVATLSLYGIDKLTPEILQQTSDTLRGFLFAGHDTTSILLQWCFYELHRCPASAKDLKNELDAVFGADASPQSVIEQLRGPQAGKLLARLPYTDAIIKEALRLHPPGTTARMTPKGSGSTITLPDGQRLVVDGLCVTPRAYVIQRHPKIFGETRDDFMPERWLGEEGARIPDSAFRPYERGPRRCTGSELANLEVRIVLAAVARRFEFVKVGQGELDLDEKGLPQLDKKGCYKTKSAMFSTYLVTCKPVDGMLSKVKIKAGPQGRNDSLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CAA3</accession>
    <name>A0A177CAA3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">mannan endo-1,4-beta-mannosidase</fullName>
            <ecNumber evidence="4">3.2.1.78</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CC84DRAFT_1187610</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random hydrolysis of (1-&gt;4)-beta-D-mannosidic linkages in mannans, galactomannans and glucomannans.</text>
            <dbReference type="EC" id="3.2.1.78"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.78" evidence="4"/>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG04583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034948.1">
        <property type="nucleotide sequence ID" value="XM_018180940.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CAA3"/>
    <dbReference type="STRING" id="1460663.A0A177CAA3"/>
    <dbReference type="GeneID" id="28764426"/>
    <dbReference type="InParanoid" id="A0A177CAA3"/>
    <dbReference type="OrthoDB" id="406631at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016985">
        <property type="term" value="F:mannan endo-1,4-beta-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046355">
        <property type="term" value="P:mannan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000076">
        <property type="entry name" value="Mannan endo-1,4-beta-mannosidase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045053">
        <property type="entry name" value="MAN-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31451">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31451:SF39">
        <property type="entry name" value="MANNAN ENDO-1,4-BETA-MANNOSIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26410">
        <property type="entry name" value="GH5_mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012904429" description="mannan endo-1,4-beta-mannosidase" evidence="9">
        <location>
            <begin position="16"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 5" evidence="10">
        <location>
            <begin position="30"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF26410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OAG04583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="373" mass="40740" checksum="321778DB484D7F7F" modified="2016-09-07" version="1">MKLLSFLPLFAAAAALPAANHLAPRASISKVDGLKFNIDGVTKYYAGTNSYWIPFLTNDNDVDVIMGHLQTSGLKILRVWGFNDVTTVPGSGTVYFQSFSGSTATINTGANGLQRLDAVVKAAEKHSIKLIINFVNNWTDYGGMAAYFSACGVSSNAQWYTTAKCQSFYQAYIKAVISRYRTSTAVFAWELANEPRCNGCQTSVLTNWIRQTSNYIRSLDSDHMIAIGDEGFGLSGDGSYPYQFSEGLDFAANLALPNVSFGTFHLYPSSWGTTNSWGNAWITAHAKVCAQLKKPCLFEEYGVSNAADHCPVESEWQKTSLAAKDSGMAADLFWQLGDTVKSTGQQTHNDGHTIYYGSSDWTCLVTNHVKQIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CAW3</accession>
    <name>A0A177CAW3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1207096</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG03830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034195.1">
        <property type="nucleotide sequence ID" value="XM_018182075.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CAW3"/>
    <dbReference type="STRING" id="1460663.A0A177CAW3"/>
    <dbReference type="GeneID" id="28765561"/>
    <dbReference type="InParanoid" id="A0A177CAW3"/>
    <dbReference type="OrthoDB" id="5307331at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="306"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="681"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="728"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="855"/>
            <end position="1052"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="310"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="340"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="684"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="728"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="751"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="788"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="823"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="898"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="966"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="988"/>
            <end position="1005"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1021"/>
            <end position="1039"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG03830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="1052" mass="118637" checksum="B4496B3B5CC72941" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CAX9</accession>
    <name>A0A177CAX9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Tat pathway signal sequence</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1092962</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ustYa family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG04874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035239.1">
        <property type="nucleotide sequence ID" value="XM_018174494.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CAX9"/>
    <dbReference type="STRING" id="1460663.A0A177CAX9"/>
    <dbReference type="GeneID" id="28757980"/>
    <dbReference type="InParanoid" id="A0A177CAX9"/>
    <dbReference type="OrthoDB" id="3687641at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021765">
        <property type="entry name" value="UstYa-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365:SF14">
        <property type="entry name" value="TAT PATHWAY SIGNAL SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365">
        <property type="entry name" value="YALI0B05434P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11807">
        <property type="entry name" value="UstYa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00035112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG04874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="197" mass="22939" checksum="4FD390696A93E9F8" modified="2016-09-07" version="1" fragment="single">VNGTLYPNHHPSVARGPPNPEKDAVWNEWEITRVFAITADQIRGMGKDPTTATKLEDEIYGLGDDAYASTFDIYHQLHCLNMLRKLVYPEYYPNARMQFPHAQDPKVMFEIHMDHCIDMLMQTIQCSGNLNLITMHWVNEEAIPFPDMSINKQCVADFDALTQWRKEHQVDPVKYVKMSRSSRREDILCTHVLTVWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CB20</accession>
    <name>A0A177CB20_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">UPF0029-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CC84DRAFT_1218190</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IMPACT family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG04765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035130.1">
        <property type="nucleotide sequence ID" value="XM_018182973.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CB20"/>
    <dbReference type="FunCoup" id="A0A177CB20">
        <property type="interactions" value="386"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CB20"/>
    <dbReference type="GeneID" id="28766459"/>
    <dbReference type="InParanoid" id="A0A177CB20"/>
    <dbReference type="OrthoDB" id="69641at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140469">
        <property type="term" value="P:GCN2-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006446">
        <property type="term" value="P:regulation of translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23822">
        <property type="entry name" value="RWD_ScYIH1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.30">
        <property type="entry name" value="Impact, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023582">
        <property type="entry name" value="Impact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001498">
        <property type="entry name" value="Impact_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036956">
        <property type="entry name" value="Impact_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006575">
        <property type="entry name" value="RWD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020569">
        <property type="entry name" value="UPF0029_Impact_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16301">
        <property type="entry name" value="IMPACT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16301:SF25">
        <property type="entry name" value="PROTEIN IMPACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01205">
        <property type="entry name" value="Impact_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05773">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00591">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50908">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00910">
        <property type="entry name" value="UPF0029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0678">Repressor</keyword>
    <keyword evidence="6" id="KW-0346">Stress response</keyword>
    <keyword evidence="5" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="RWD" evidence="8">
        <location>
            <begin position="9"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="111"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAG04765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="280" mass="31186" checksum="5447567D5A4FA3FE" modified="2016-09-07" version="1">MSTNEAIQDEIISINSIFEEDTLVGLDDDSTLFSLRLPSLRDITLRLEFPQDYPDTPPSILGTESVGQDVPKGMGNKVVHMARDVLARVYDPGEACIYDLLEEVRDAIEKAEEDGSIQRDRQDEPEPPPEAPQDLTQDLGPEPPWIIAPQITEKKSVFLARVAPVSSPDQAKQYVAHLLATDKKAAKATHNMTAWRIKGPNETSYQDCDDDGETAAGGRMLHLMQLMDVWNVMVVVTRWYGGIQLGPDRFRIINTASREALVLGGFARDTKEENKKKGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CB29</accession>
    <name>A0A177CB29_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_872467</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG03900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034265.1">
        <property type="nucleotide sequence ID" value="XM_018187738.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CB29"/>
    <dbReference type="GeneID" id="28771224"/>
    <dbReference type="InParanoid" id="A0A177CB29"/>
    <dbReference type="OrthoDB" id="3799841at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="244"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="8"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAG03900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="324" mass="36111" checksum="E13FD523F6EB3345" modified="2016-09-07" version="1">MSWPEGNPITSAPPANNVSAQNNHVKRSGLGRPQQDVQQDSVPHSCICLHSRPCCSGCCAWPDLDLLWPFDPFFPTPRGAGHSSTSVAPDIVSSATQMITEQLSPDTVLRSDSVFVDGSFSLWNENSIYLDQVEEALSWSSLSSRSISGNQCPCVNAQQQLPPTFFEQEFELKSLGPAGWKSSQSSEAYSPSLLMSLYNCTRTPNSVCECVRPNSTTHMRSDPISKLAIDRARLPKCKLRKRRFPCPLNPCQKVFGSRNDLERHLATRKHRRESGSDRVNKFRCTVSWCKRKSEGFMRKDHWARHMGKMHPDLAVGDGEGGDAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CBD5</accession>
    <name>A0A177CBD5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Rgp1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_817124</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG05003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035368.1">
        <property type="nucleotide sequence ID" value="XM_018187525.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CBD5"/>
    <dbReference type="FunCoup" id="A0A177CBD5">
        <property type="interactions" value="55"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CBD5"/>
    <dbReference type="GeneID" id="28771011"/>
    <dbReference type="InParanoid" id="A0A177CBD5"/>
    <dbReference type="OrthoDB" id="1918at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014848">
        <property type="entry name" value="Rgp1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12507">
        <property type="entry name" value="REDUCED GROWTH PHENOTYPE 1 RGP1, YEAST -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08737">
        <property type="entry name" value="Rgp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="556"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="599"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="63"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="556"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="570"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="600"/>
            <end position="611"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG05003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="832" mass="89817" checksum="3092A94B530BABDF" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CBH0</accession>
    <name>A0A177CBH0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">High-affinity nicotinic acid transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CC84DRAFT_1150128</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG04169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034534.1">
        <property type="nucleotide sequence ID" value="XM_018176692.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CBH0"/>
    <dbReference type="FunCoup" id="A0A177CBH0">
        <property type="interactions" value="152"/>
    </dbReference>
    <dbReference type="GeneID" id="28760178"/>
    <dbReference type="InParanoid" id="A0A177CBH0"/>
    <dbReference type="OrthoDB" id="2962993at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000034">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000068">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF57">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="139"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="169"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="202"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="271"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="311"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="335"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="358"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="397"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="428"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="43"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="450"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAG04169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="489" mass="54771" checksum="14F49208E1EE74EA" modified="2016-09-07" version="1">MDQPKIANEKVGSFVSVAYGDVEPQGWDAQNTKRLLRKLDWHIIPFMSLIYLLCFLDRTNIGNARLDHLEQDLKLHGLQYNDCLAILFPFYIAAEIPSNIMMKRVRPSIWLTFIMFCWSVSMIGQGFVKNYSGLMATRVFLGVFEGGLFPGVNYFITQWYVRKECGFRMALFFSAATLAGAFGGILARGIAEMNGVGGRAAWAWIFILEGLLSVVVSLAAYWCIYDYPSTARFLTETEREEVQRRLQAEQGHLSNDFDMKYVWQAIGDWKIYIHMFICMAGFCPIYSFALFLPTIIKSMGYTANEAQLMSVPPYVAACFFTIIASWYADRVGKRGIFMLGFQLVALLGFSLLCGSGKASVQYAGTVFAAIGIYPQIPLGMAWNSGNIGGSLKRGTGIAMQVMGGNCGGIIASYVYVSRDGPRYITGHSILIGVVSAAFFLTLFMSTWCRLENARRDKVAAERGVQDLTEEQKLLERELADNVPWFRYAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CBI0</accession>
    <name>A0A177CBI0_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Large ribosomal subunit protein uL29m</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">54S ribosomal protein L4, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CC84DRAFT_1166317</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uL29 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG04222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034587.1">
        <property type="nucleotide sequence ID" value="XM_018178928.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CBI0"/>
    <dbReference type="STRING" id="1460663.A0A177CBI0"/>
    <dbReference type="GeneID" id="28762414"/>
    <dbReference type="InParanoid" id="A0A177CBI0"/>
    <dbReference type="OrthoDB" id="270763at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.330.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038340">
        <property type="entry name" value="MRP-L47_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010729">
        <property type="entry name" value="Ribosomal_uL29_mit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21183:SF18">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL29M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21183">
        <property type="entry name" value="RIBOSOMAL PROTEIN L47, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06984">
        <property type="entry name" value="MRP-L47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="35"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="223"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="226"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="254"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="275"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAG04222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="285" mass="31968" checksum="4CE50054ADC8F382" modified="2016-09-07" version="1">MAIPTSRILRPSLPSAPRDTALSLFASPTQCTRRTPLARFSTSPSLLKGPGRGDNNKNRGVSGVRHTGLRPRQTLSVKNKDYENQKLPTPVQPTSQISGDPDHGLYGFFKDKKLLLTPVEEGRHGRAWTVNELRNRDWETLQQLWWVCVKERNRLATAHYEHRRQGAGHGQTEMEERDETIQETMKAILDTLAERNTAYEEAYKLAKHDPTIDLGRTGHQYQESSYDAEDMYQEDDNLSDPVGVVPKEAAEGQPPQSETISVQPSSVPLPEAAPSKQQPKQPNAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CC57</accession>
    <name>A0A177CC57_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metallo-hydrolase/oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_791127</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG04377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034742.1">
        <property type="nucleotide sequence ID" value="XM_018187402.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CC57"/>
    <dbReference type="STRING" id="1460663.A0A177CC57"/>
    <dbReference type="GeneID" id="28770888"/>
    <dbReference type="InParanoid" id="A0A177CC57"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07713">
        <property type="entry name" value="DHPS-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041712">
        <property type="entry name" value="DHPS-like_MBL-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052926">
        <property type="entry name" value="Metallo-beta-lactamase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13754">
        <property type="entry name" value="METALLO-BETA-LACTAMASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13754:SF13">
        <property type="entry name" value="METALLO-BETA-LACTAMASE SUPERFAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_3G07630)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="1">
        <location>
            <begin position="84"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG04377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="354" mass="37922" checksum="69330C90A487D209" modified="2016-09-07" version="1">MEGSAMADRHALKEIDSVTIQVLVDNELDPITKSQNPAVVDATSFRLRELPAGERGPAAMEMRMEDICCGAHGLSLLITASAGDASHTLLFDAGPEEDVFEKNVARSRADLSTVEHVHLSHWHRDHSGGLPRALRMINAARKADSALGKPVMDVHPDRPIYRGFNAGPFVASLEADPTFEELEGAGARVVREGGTHGVLEDTFLVSGEVPRNTAYEVGFPRGMRFTAEGVWVPDELIRDERFVVCKLRGKGLVVFAGCSHPGIVNICQHALAIGGGAPLYAVVGGFHLADGDAAKLEASIQGLQALKPKILMPGHCTGWRFKFKIEQEMPGALVPCFSGTRYTLSGEGVGEGVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CDF0</accession>
    <name>A0A177CDF0_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 12">tRNA (uracil-O(2)-)-methyltransferase</fullName>
            <ecNumber evidence="4 12">2.1.1.211</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CC84DRAFT_809051</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Adenosyl-L-methionine (AdoMet)-dependent tRNA (uracil-O(2)-)-methyltransferase.</text>
    </comment>
    <comment type="function">
        <text evidence="1">Probable adenosyl-L-methionine (AdoMet)-dependent tRNA (uracil-O(2)-)-methyltransferase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 12">
            <text>uridine(44) in tRNA(Ser) + S-adenosyl-L-methionine = 2'-O-methyluridine(44) in tRNA(Ser) + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:43100"/>
            <dbReference type="Rhea" id="RHEA-COMP:10339"/>
            <dbReference type="Rhea" id="RHEA-COMP:10340"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74478"/>
            <dbReference type="EC" id="2.1.1.211"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 12">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the TRM44 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.211" evidence="4 12"/>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG04912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035277.1">
        <property type="nucleotide sequence ID" value="XM_018187503.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CDF0"/>
    <dbReference type="FunCoup" id="A0A177CDF0">
        <property type="interactions" value="81"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CDF0"/>
    <dbReference type="GeneID" id="28770989"/>
    <dbReference type="InParanoid" id="A0A177CDF0"/>
    <dbReference type="OrthoDB" id="10047021at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141101">
        <property type="term" value="F:tRNA(Ser) (uridine(44)-2'-O-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011671">
        <property type="entry name" value="tRNA_uracil_MeTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21210">
        <property type="entry name" value="TRNA (URACIL-O(2)-)-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21210:SF0">
        <property type="entry name" value="TRNA (URACIL-O(2)-)-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07757">
        <property type="entry name" value="AdoMet_MTase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 12" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 12" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="8 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="10 12" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="9"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="19"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU368004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OAG04912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="617" mass="69321" checksum="AB3EE30B2404AE93" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CEC0</accession>
    <name>A0A177CEC0_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_1092010</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG05656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036021.1">
        <property type="nucleotide sequence ID" value="XM_018174424.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CEC0"/>
    <dbReference type="STRING" id="1460663.A0A177CEC0"/>
    <dbReference type="GeneID" id="28757910"/>
    <dbReference type="InParanoid" id="A0A177CEC0"/>
    <dbReference type="OrthoDB" id="5365701at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052233">
        <property type="entry name" value="Rho-type_GEFs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46572">
        <property type="entry name" value="RHO1 GDP-GTP EXCHANGE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46572:SF1">
        <property type="entry name" value="RHO1 GUANINE NUCLEOTIDE EXCHANGE FACTOR TUS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="3">
        <location>
            <begin position="98"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="43"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="263"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="12"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="43"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="69"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAG05656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="458" mass="51595" checksum="F028E23E2E2EC331" modified="2016-09-07" version="1">MENEKPPPLPPRRNASPLLAPAKPELKKTSSWDEIFAPLATTSPLPLTNLSSENNRSQAGEDSVPKSPPLLAKKLSSLSSPDNGSKGIASPASTEEIKPGKIWTSVLLEEEQYIERMNKFTNIFYGVVIKEWPVLEKHMEAIVLARQLAPLHQEYILDVVKAQTQQNPFAVCDPRLFATWASKTYKVLKEYSRRFPHALYALRLTQSRDKKFGPCIETIGLNLTKAGQSWEDHLVLPIAQLDTYITKLQGIAQWLDEGSAPILTKEQSRVKATLETLQRLKTQCSDLADKSISQEEIQSLHRKVHTVDTSLVDVLELSSPDRRIVYHGSTALKLNNRGPWKPMQVVLLDNYIFWGKLKSTKDTNHKGMMIDSIRVIEKPVPVTQIAIRLPLDSTKTRTSSYLDELPRGVILYELFVDINVKPGSFTTLTIGTFSYEERSNWYQKLSEVAGTKSPQIPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CFV6</accession>
    <name>A0A177CFV6_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1164095</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG05610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035975.1">
        <property type="nucleotide sequence ID" value="XM_018178408.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CFV6"/>
    <dbReference type="GeneID" id="28761894"/>
    <dbReference type="InParanoid" id="A0A177CFV6"/>
    <dbReference type="OrthoDB" id="3750626at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="466"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="471"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="486"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="499"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG05610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="528" mass="59724" checksum="0024579D684C04D1" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CGF3</accession>
    <name>A0A177CGF3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1176020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG05929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036294.1">
        <property type="nucleotide sequence ID" value="XM_018180186.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CGF3"/>
    <dbReference type="GeneID" id="28763672"/>
    <dbReference type="InParanoid" id="A0A177CGF3"/>
    <dbReference type="OrthoDB" id="10621715at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG05929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="163" mass="18133" checksum="92DA8416AAA4C938" modified="2016-09-07" version="1">MTYSKSRRQMAFGGQRDESVRTLPRGVQGLSHRLVGTSRWDFEECHVDAIGPQSWRWLGQQRVPRAKLVNGFNSGVAAVPRHRRRGYKGCSEGFHYAQIFVLILTNSTCRICPHQYSSWGFAPVLGTVPSSMITATSTSSTGCTEFEVETKQCNRALGYNTGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CGH6</accession>
    <name>A0A177CGH6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HET-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1176458</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG06466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036831.1">
        <property type="nucleotide sequence ID" value="XM_018180224.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CGH6"/>
    <dbReference type="STRING" id="1460663.A0A177CGH6"/>
    <dbReference type="GeneID" id="28763710"/>
    <dbReference type="InParanoid" id="A0A177CGH6"/>
    <dbReference type="OrthoDB" id="5428863at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF1">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="80"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG06466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="294" mass="33271" checksum="3A74B7227DFFE207" modified="2016-09-07" version="1">MNLEKPLYTFNAICGAKGDKNALRIVGPCPDYALIRSWLGQCNKEHRECQILGSTENLKIITLIDVQNQRLVRYKPGLQYVALSYVWGGAPVPERIPGRPFELPNNISKTINHAMVVAENIGIPFLWADAVCIDQDKVEEKNQQLPLMNYIYEHASATIIALGDHANFGLPGVQGGPERLMQLVAEFGPLQLMARNPLLSSQIQSSAWSKRGWTYQEGLFSRRCIYFSQHQKIRPLQSLSPGRTALIPMRLIFLETHCCNPTFTQEAMSWVTWTFSLHTSMNIALEKSRMERTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2023-06-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CHT9</accession>
    <name>A0A177CHT9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_762245</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG06370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036735.1">
        <property type="nucleotide sequence ID" value="XM_018187339.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CHT9"/>
    <dbReference type="GeneID" id="28770825"/>
    <dbReference type="InParanoid" id="A0A177CHT9"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="223"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG06370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="242" mass="27634" checksum="D68D8C6728702B95" modified="2016-09-07" version="1">MILSWRMDFLASRPCAEIVRSSHHVAIPSLVRPFVPQVCASLHVGAAFDWSYEPKRASSVTLISRTCDRSLLLGQWTISTQTLCANSLHQNIQLFQLIARLISYLILCDFLEPLTPYGKLFSANRLYLCVGRRKRRVHNARLSKDRCTRGWYVRSWRRTKRSNIGTRGSDTESTAAEWNGTLEASFAWKFSHLRSRWVSGLHGLFMDMYDLKCITLGAPLATDRSSSEHHSSRSCVYHPSVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CHY5</accession>
    <name>A0A177CHY5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_622826</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG06851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037216.1">
        <property type="nucleotide sequence ID" value="XM_018186927.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CHY5"/>
    <dbReference type="GeneID" id="28770413"/>
    <dbReference type="InParanoid" id="A0A177CHY5"/>
    <dbReference type="OrthoDB" id="3799619at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="309"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG06851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="357" mass="40084" checksum="9C389D1D36A56A5B" modified="2016-09-07" version="1">MDMLYHYCFTNGSDDQDDTTRKNLQALIVSMAALESEMSAFNVYVVTQHMHDKPLNMWPKYEQYCGLGTASKELEDTVKGIKTLVQSGSFSNMYCIDMYTFQAREISIKVSNTIATVMKTMSDKTIDIETEARTDAHESTEQDTAIVAIMFELAEVIKHLTTAAESTWAALNLLETIAAKSSLQQANKFAKMQSYLPWACCAFTAILALSTFFNGLHNASQPPDLNDMRSSIAEMQSVCGLVNKNLDIAAYVRNDTLAEIDQRLLAIEHAWQDNNERIDNVWEALGPPNAEGTYFIQEMGAPDERPIDSRVLKARMDKLEADALEFKRQVQRAEVRTASRLNKLDRKRGGSGETEVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CI85</accession>
    <name>A0A177CI85_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_619230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG06692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037057.1">
        <property type="nucleotide sequence ID" value="XM_018186894.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CI85"/>
    <dbReference type="GeneID" id="28770380"/>
    <dbReference type="InParanoid" id="A0A177CI85"/>
    <dbReference type="OrthoDB" id="3786709at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="278"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="480"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="95"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="280"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="491"/>
            <end position="578"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG06692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="589" mass="67528" checksum="5B46ACA62E56292A" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CJH5</accession>
    <name>A0A177CJH5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1216001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG06989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037354.1">
        <property type="nucleotide sequence ID" value="XM_018182761.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CJH5"/>
    <dbReference type="GeneID" id="28766247"/>
    <dbReference type="InParanoid" id="A0A177CJH5"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="131"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG06989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="190" mass="20833" checksum="6D3C107C946AC4C1" modified="2016-09-07" version="1">MKEELAQELARQNKDQIASRGGISNTLEEIAAKQMGSTVASPVLVSQLPVPEAFARLDEGGNQRVIEAVRTAGNGRTVAGQLEKPTVPAVPQNSTVEQNTVAALVECTVREMQARQAKQHAQDKQANRHAQTTQTTQTVQTTQPTQARRPGLRLDQELYPEEDSQNLLRENTDEEDGDEEGAWEGEDNGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CK34</accession>
    <name>A0A177CK34_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CC84DRAFT_1163452</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG07238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037603.1">
        <property type="nucleotide sequence ID" value="XM_018178268.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CK34"/>
    <dbReference type="FunCoup" id="A0A177CK34">
        <property type="interactions" value="103"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CK34"/>
    <dbReference type="GeneID" id="28761754"/>
    <dbReference type="InParanoid" id="A0A177CK34"/>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd19071">
        <property type="entry name" value="AKR_AKR1-5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000002">
        <property type="entry name" value="2,5-diketo-D-gluconic acid reductase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827">
        <property type="entry name" value="2,5-DIKETO-D-GLUCONIC ACID REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827:SF13">
        <property type="entry name" value="ALDO_KETO REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00063">
        <property type="entry name" value="ALDOKETO_REDUCTASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="5">
        <location>
            <begin position="29"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="4">
        <location>
            <position position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAG07238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="284" mass="31399" checksum="7BD56EBE7E06D56C" modified="2016-09-07" version="1">MSYSLASRTKLANGLSMPTIHLGVYLTSGSETYQACRWALEAGYRGIDSAQMYHNEKESGKAVSDFLSSSDNTDSLKREDIHFTSKLASNSSYDAARKSITRSVKGCGLGYIDLFLLHSPHGGKKARLESWRAVEDAIDDGEIRIGGVSNYGVKHLQELLDSKPRILPAVNQIEIHPFNTRFDIADFCQEHDIVVEAYAPLVRALKMKHPVIASLSKKYSCTPGQLLVSWSLQHGYVPLPKSVNKARIVENGEVGGFSIDDSDIKKMDALDEYLVTDWDPTDTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CK57</accession>
    <name>A0A177CK57_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1242811</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG07352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037717.1">
        <property type="nucleotide sequence ID" value="XM_018184093.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CK57"/>
    <dbReference type="GeneID" id="28767579"/>
    <dbReference type="InParanoid" id="A0A177CK57"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG07352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="147" mass="16752" checksum="D390A3C392CFF423" modified="2016-09-07" version="1">MVDVRKCTPVGVGIQCLGRRGYLSASPASEKMTRNLNSWVTTDVPVSNCYPSTRLLSRILRLDIAQTYQSYSTSLLQPRPNIPISYIPGPKSAARHILNIHHVHHHHHHHHRNQTAPNPPRQTCRQRRLAVLPIIHLHLQPHHSKPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CKJ7</accession>
    <name>A0A177CKJ7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NADH-ubiquinone oxidoreductase-like protein 21 kDa subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_1114198</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038388.1">
        <property type="nucleotide sequence ID" value="XM_018175388.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CKJ7"/>
    <dbReference type="STRING" id="1460663.A0A177CKJ7"/>
    <dbReference type="GeneID" id="28758874"/>
    <dbReference type="InParanoid" id="A0A177CKJ7"/>
    <dbReference type="OrthoDB" id="196140at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053229">
        <property type="entry name" value="NADH-Q_oxidrdct_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024549">
        <property type="entry name" value="NADH-UbQ_OxRdtase_su21_C_fun"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019721">
        <property type="entry name" value="NADH-UbQ_OxRdtase_su21_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34062:SF1">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 21KDA SUBUNIT N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34062">
        <property type="entry name" value="OXIDOREDUCTASE 21 KDA SUBUNIT, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G04750)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10785">
        <property type="entry name" value="NADH-u_ox-rdase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12853">
        <property type="entry name" value="NADH_u_ox_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="NADH-ubiquinone oxidoreductase 21kDa subunit N-terminal" evidence="2">
        <location>
            <begin position="22"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="NADH-ubiquinone oxidoreductase 21kDa subunit C-terminal fungi" evidence="3">
        <location>
            <begin position="115"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAG08023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="189" mass="21388" checksum="E9A5E94A0F6A44D6" modified="2016-09-07" version="1">MSSTAETTIGQPVVPDKIPTGEYPLIDNDPHFSRVIRYTRPSDWLTGAAVGALSPGLMLYWERVSPSFVGKGGFAPVMRMSCAVGLTGAFLFAYSRTTSRFYGARENRREIDMDMREMVAKVKKGEPLYGKSELTEHMQGVAHRNSRYAGVFSHVIPWPNFVHHPYHGVDTAKYYRQAELELEQERQRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CKV8</accession>
    <name>A0A177CKV8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CHL4-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1186426</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG07469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037834.1">
        <property type="nucleotide sequence ID" value="XM_018180858.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CKV8"/>
    <dbReference type="FunCoup" id="A0A177CKV8">
        <property type="interactions" value="42"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CKV8"/>
    <dbReference type="GeneID" id="28764344"/>
    <dbReference type="InParanoid" id="A0A177CKV8"/>
    <dbReference type="OrthoDB" id="6585699at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034080">
        <property type="term" value="P:CENP-A containing chromatin assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.720">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007902">
        <property type="entry name" value="Chl4/mis15/CENP-N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05238">
        <property type="entry name" value="CENP-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="327"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="329"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="356"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="388"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="412"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG07469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="508" mass="56533" checksum="EEE1ECCE0F34589B" modified="2016-09-07" version="1">MAPKPNTAVPDYRNVPHSHRLPTSHREVQRTFTKLSRQSLVSLANQWLAKKNRDFCRPYLLGDRGADAEEDDEQYTPAQSYEELQEIYKELAARKGGKREIQDRILEGDWRTGISMYQLATAEIQYLLDHPNSLRWTAKRLAKIPSGKNMALDMEVTNDSEHLPRFQAQTFMANLARELTPLMKAHYLLIKIKTMPMTILRVYIHDSPYSTEASLAIDNGSSDNARAVFFIWPNGSNFVYSSIANHFGQVISDDGRHLRDIVQQAIPKAFSRPSARYQLASTNFTTKSLDALLAYRGPGKSNAASGGWSIFQDHNFSQNALDFITSQNDHGKEKNGQRKDGAVGATAKAGPGRPKRTLEDKETSDAKRRREVAAGRFGSSAQPNDGQGLERVEVRIDDAFPAMPNSADDADTSNISEQPANRNRRGRPSLLDRSLDEIEELEGADAWVPDVRVVFQGSHVFAGVRQLVEQGIVDGEKMPGWMTGEAGVTIGAVKEGRIRTKSGQIPGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CL04</accession>
    <name>A0A177CL04_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Rho GTPase activation protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_1175396</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG07632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037997.1">
        <property type="nucleotide sequence ID" value="XM_018180151.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CL04"/>
    <dbReference type="STRING" id="1460663.A0A177CL04"/>
    <dbReference type="GeneID" id="28763637"/>
    <dbReference type="InParanoid" id="A0A177CL04"/>
    <dbReference type="OrthoDB" id="410651at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00159">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45808">
        <property type="entry name" value="RHO GTPASE-ACTIVATING PROTEIN 68F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45808:SF2">
        <property type="entry name" value="RHO GTPASE-ACTIVATING PROTEIN 68F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13716">
        <property type="entry name" value="CRAL_TRIO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="2">
        <location>
            <begin position="31"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="3">
        <location>
            <begin position="218"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="472"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="610"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="472"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="555"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="664"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="700"/>
            <end position="710"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAG07632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="804" mass="88768" checksum="51DE7F8839A7B002" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CLC7</accession>
    <name>A0A177CLC7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ricin B lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1162057</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038406.1">
        <property type="nucleotide sequence ID" value="XM_018177895.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CLC7"/>
    <dbReference type="GeneID" id="28761381"/>
    <dbReference type="InParanoid" id="A0A177CLC7"/>
    <dbReference type="OrthoDB" id="2986744at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012091086" description="Ricin B lectin domain-containing protein" evidence="2">
        <location>
            <begin position="16"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="29"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG08041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="212" mass="21083" checksum="6C72A95802BC85E8" modified="2016-09-07" version="1">MKFSILLMIAATASAAVVAPRHHKGRKGGNAAAQQGQAAQTGNGATQNAQTGGQATSGGNNNQAATGGGALARGATTIVLKETQGVPGNECITFRNNGEMVDAACVNTAADRQLQASTVNGQPVLAVQRSFTAGFRPDLVGVDACVGNNGTTFLALPCNSASLDPVTFSNNNLVAASGACQSGHDGAAQITVDQSGQNCAELTSTETAATPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CLR1</accession>
    <name>A0A177CLR1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1173713</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038546.1">
        <property type="nucleotide sequence ID" value="XM_018180053.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CLR1"/>
    <dbReference type="STRING" id="1460663.A0A177CLR1"/>
    <dbReference type="GeneID" id="28763539"/>
    <dbReference type="InParanoid" id="A0A177CLR1"/>
    <dbReference type="OrthoDB" id="5345494at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036280">
        <property type="entry name" value="Multihaem_cyt_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48695">
        <property type="entry name" value="Multiheme cytochromes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG08181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="523" mass="57871" checksum="0D4F3A263F680829" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CLW8</accession>
    <name>A0A177CLW8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Alcohol oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CC84DRAFT_1258801</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG07777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038142.1">
        <property type="nucleotide sequence ID" value="XM_018184858.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CLW8"/>
    <dbReference type="STRING" id="1460663.A0A177CLW8"/>
    <dbReference type="GeneID" id="28768344"/>
    <dbReference type="InParanoid" id="A0A177CLW8"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF210">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE OXIDOREDUCTASE N-TERMINAL DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00623">
        <property type="entry name" value="GMC_OXRED_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="4">
        <location>
            <begin position="89"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAG07777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="630" mass="68756" checksum="882F4A6A51DFBA24" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CLY2</accession>
    <name>A0A177CLY2_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Deoxyhypusine hydroxylase</fullName>
            <shortName evidence="9">DOHH</shortName>
            <ecNumber evidence="9">1.14.99.29</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Deoxyhypusine dioxygenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Deoxyhypusine monooxygenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LIA1</name>
        <name evidence="10" type="ORF">CC84DRAFT_1162463</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L-lysine intermediate to form hypusine, an essential post-translational modification only found in mature eIF-5A factor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>[eIF5A protein]-deoxyhypusine + AH2 + O2 = [eIF5A protein]-hypusine + A + H2O</text>
            <dbReference type="Rhea" id="RHEA:14101"/>
            <dbReference type="Rhea" id="RHEA-COMP:10144"/>
            <dbReference type="Rhea" id="RHEA-COMP:12592"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:82657"/>
            <dbReference type="ChEBI" id="CHEBI:91175"/>
            <dbReference type="EC" id="1.14.99.29"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="9">Binds 2 Fe(2+) ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Protein modification; eIF5A hypusination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the deoxyhypusine hydroxylase family.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.29" evidence="9"/>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038888.1">
        <property type="nucleotide sequence ID" value="XM_018178000.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CLY2"/>
    <dbReference type="FunCoup" id="A0A177CLY2">
        <property type="interactions" value="894"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CLY2"/>
    <dbReference type="GeneID" id="28761486"/>
    <dbReference type="InParanoid" id="A0A177CLY2"/>
    <dbReference type="OrthoDB" id="421002at2759"/>
    <dbReference type="UniPathway" id="UPA00354"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019135">
        <property type="term" value="F:deoxyhypusine monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03101">
        <property type="entry name" value="Deoxyhypusine_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027517">
        <property type="entry name" value="Deoxyhypusine_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004155">
        <property type="entry name" value="PBS_lyase_HEAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12697:SF5">
        <property type="entry name" value="DEOXYHYPUSINE HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12697">
        <property type="entry name" value="PBS LYASE HEAT-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13646">
        <property type="entry name" value="HEAT_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00567">
        <property type="entry name" value="EZ_HEAT"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 9" id="KW-0386">Hypusine biosynthesis</keyword>
    <keyword evidence="6 9" id="KW-0408">Iron</keyword>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="binding site" evidence="9">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="238"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="270"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="271"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAG08523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="332" mass="36279" checksum="C2A26CB2C0EC8F71" modified="2016-09-07" version="1">MAAPETPAKDAQVQALRTILTSEQEALARRFRALFSLKYLASLQPPTEQTVPAIEAIAAAFSSPSALLKHELAYCLGQSRNDAAISPLRHVLQDKDEDPMCRHEAAEALGALGDKGSLDLLKGLRDDAKELDVVRETCDIAVDRIEWEHGIQSKDEHLKKSDFASIDPAPPLPQDQQAPSIPELEKKLLDTSLPLFKRYRAMFALRDLASPPDLPSAVPAVQSLARGFADPSALFRHEIAFVFGQLSHPASIPSLQDTLSNQKEESMVRHEAAEALGSLGDEDGVEEFLKKFLNDPEQVVRDSVIVALDMAEFEKNGEAEYAIVPEGKAVAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CM12</accession>
    <name>A0A177CM12_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">MAPEG-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CC84DRAFT_1056656</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038711.1">
        <property type="nucleotide sequence ID" value="XM_018173544.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CM12"/>
    <dbReference type="GeneID" id="28757030"/>
    <dbReference type="InParanoid" id="A0A177CM12"/>
    <dbReference type="OrthoDB" id="2421200at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.550">
        <property type="entry name" value="Membrane associated eicosanoid/glutathione metabolism-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023352">
        <property type="entry name" value="MAPEG-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001129">
        <property type="entry name" value="Membr-assoc_MAPEG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35371:SF1">
        <property type="entry name" value="BLR7753 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35371">
        <property type="entry name" value="INNER MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01124">
        <property type="entry name" value="MAPEG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161084">
        <property type="entry name" value="MAPEG domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAG08346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="204" mass="21408" checksum="8983D5A0B1400484" modified="2016-09-07" version="1" fragment="single">MSDDKKQKAKQVAAENGVVNPGGAAILGAAPLYLALIPLTSYLTKPDSVVQKLSETLIKLVPGVGISSISSGRAIPALSAIYLFWTFGVSGAASAAGQAMGREEGFDNDHPRKHVTELDGLPLRLRSAHYALMENFPGFALAAALAQVIAPTDSQVVNLLGFHVVAKLLVHYPAYLANIAVPRTLAHISATSALINVCWRLATG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CMG0</accession>
    <name>A0A177CMG0_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7053 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1173677</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038497.1">
        <property type="nucleotide sequence ID" value="XM_018180051.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CMG0"/>
    <dbReference type="STRING" id="1460663.A0A177CMG0"/>
    <dbReference type="GeneID" id="28763537"/>
    <dbReference type="InParanoid" id="A0A177CMG0"/>
    <dbReference type="OrthoDB" id="5078320at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055481">
        <property type="entry name" value="DUF7053"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38117">
        <property type="entry name" value="NACHT AND WD40 DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38117:SF2">
        <property type="entry name" value="NACHT AND WD40 DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23155">
        <property type="entry name" value="DUF7053"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7053" evidence="2">
        <location>
            <begin position="5"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="277"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="328"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="277"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="328"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="362"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG08132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="383" mass="43176" checksum="9414195D70A0D00F" modified="2016-09-07" version="1">MGLTRKKTTYINITPIPSFIPRQLAIDMLHSHGEIIELNPLVLSFEAVKAPRDAPADEFYATWYEITERIQYIPGIGKLGSGIIKFKGCFHDMPWGLQTHTYAPANVDVRNKWQICGTQPGEPPETQELGIGAPAEGLYLREDIEIKCNMTMTSFVKKEMKAASKVLVDRMLKKAELLDSGAISAMMENGKLKTINPADRSSVAKLAASPDSPNQQPYKLPNSPMRSPAFPATQMYHPSKHTGEQGAVMELPGDFYHPQPSPNHLNPQDRRYSIASELSSNEQNAPDSRWSYQSASTRPSSYNSSGGMRSPGLEYNKEYLAELPTMNEAHEEHAERRELQEVPWPSKEQHQYRYNPQDFARMQQQYTQPPQYSAYDTRRPSGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CMN0</accession>
    <name>A0A177CMN0_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Copper transport protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CC84DRAFT_1174225</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039169.1">
        <property type="nucleotide sequence ID" value="XM_018180083.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CMN0"/>
    <dbReference type="FunCoup" id="A0A177CMN0">
        <property type="interactions" value="513"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CMN0"/>
    <dbReference type="GeneID" id="28763569"/>
    <dbReference type="InParanoid" id="A0A177CMN0"/>
    <dbReference type="OrthoDB" id="161814at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005375">
        <property type="term" value="F:copper ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007274">
        <property type="entry name" value="Cop_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12483:SF115">
        <property type="entry name" value="COPPER TRANSPORT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12483">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 31 COPPER TRANSPORTERS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04145">
        <property type="entry name" value="Ctr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="4" id="KW-0187">Copper transport</keyword>
    <keyword evidence="4" id="KW-0406">Ion transport</keyword>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="174"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="197"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="136"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAG08804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="225" mass="24891" checksum="2273FDBFA0E3BD93" modified="2016-09-07" version="1">MDHSHMDHGGHEGHNMPGMDHGPQCNMNMLFTWDTTDLCIVFKSWHISGTGTLILSLLAIVLMTAGYEAVREASRRYDAHTKRVSEGRSSGDDLSRTCMRTTRTGGDMLEVSVDEGRKNMSRDERVKWSIAEKRPVDAAHAPDESSESSSLLWPGRHGRTSASASEQQTKTVKALFYAVQVFYSFFIMLLFMTYNGWVMLSVAVGAFVGYLLFSGGPSAKTAACH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CMW3</accession>
    <name>A0A177CMW3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CC84DRAFT_1239886</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038966.1">
        <property type="nucleotide sequence ID" value="XM_018183992.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CMW3"/>
    <dbReference type="STRING" id="1460663.A0A177CMW3"/>
    <dbReference type="GeneID" id="28767478"/>
    <dbReference type="InParanoid" id="A0A177CMW3"/>
    <dbReference type="OrthoDB" id="1560166at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940:SF7">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE-LIKE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAG08601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="314" mass="33683" checksum="7CAE7A34F74B7DCF" modified="2016-09-07" version="1">MKAVVIEQPGAPFILPTIAVPSPAPGEILIKVLGCGVCLFRLLRPARWIWHLPRIPEHEVIGSWSLGGKVGGGWHCGYDGTCAGCQGVNGVTRDGGRVFAFCHAEDCVLRCEAVIRIPEDADLVAYAPLMAVGPRATIGEYATCRHSCFPTIVSYSRDWRPGSSEHSVAPSTSDSKRGFAMQLGATNYVDTSKRDAANELQDMGGASLIVVTAPNAYIISGLVGALGRLGKLLILARNSALSWSFLSRGLKLEIGGSVHVWPAGHALDSEEAIDFAKRQGVKCMEEKFLLEMVEKAIKALTSNAVRFRSVPVIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CMW4</accession>
    <name>A0A177CMW4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1257125</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038593.1">
        <property type="nucleotide sequence ID" value="XM_018184699.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CMW4"/>
    <dbReference type="GeneID" id="28768185"/>
    <dbReference type="InParanoid" id="A0A177CMW4"/>
    <dbReference type="OrthoDB" id="3792554at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG08228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="150" mass="16812" checksum="9618956F6F2DC0B5" modified="2016-09-07" version="1">MPSNLETLHDALTARSIACTLSDEDSFILSFTATPLSYTLRIAGHRPSTIVLVLNLSTCVTLLYARSHGATQAASDRTDMLVEAGYVGVQEEDDFMPQIIRLYDLSKVQDRTALVKRILLMRDLERKFKAPFEEGKWMGKQKSFYSGYAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CP38</accession>
    <name>A0A177CP38_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">AA9 family lytic polysaccharide monooxygenase</fullName>
            <ecNumber evidence="5">1.14.99.56</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Endo-beta-1,4-glucanase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Glycosyl hydrolase 61 family protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_583066</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Lytic polysaccharide monooxygenase (LMPO) that depolymerizes crystalline and amorphous polysaccharides via the oxidation of scissile alpha- or beta-(1-4)-glycosidic bonds, yielding C1 and/or C4 oxidation products. Catalysis by LPMOs requires the reduction of the active-site copper from Cu(II) to Cu(I) by a reducing agent and H(2)O(2) or O(2) as a cosubstrate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>[(1-&gt;4)-beta-D-glucosyl]n+m + reduced acceptor + O2 = 4-dehydro-beta-D-glucosyl-[(1-&gt;4)-beta-D-glucosyl]n-1 + [(1-&gt;4)-beta-D-glucosyl]m + acceptor + H2O.</text>
            <dbReference type="EC" id="1.14.99.56"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 5">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="5">Has a modular structure: an endo-beta-1,4-glucanase catalytic module at the N-terminus, a linker rich in serines and threonines, and a C-terminal carbohydrate-binding module (CBM).</text>
    </comment>
    <dbReference type="EC" id="1.14.99.56" evidence="5"/>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038924.1">
        <property type="nucleotide sequence ID" value="XM_018186765.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CP38"/>
    <dbReference type="GeneID" id="28770251"/>
    <dbReference type="InParanoid" id="A0A177CP38"/>
    <dbReference type="OrthoDB" id="4849160at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008810">
        <property type="term" value="F:cellulase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030248">
        <property type="term" value="F:cellulose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd21175">
        <property type="entry name" value="LPMO_AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049892">
        <property type="entry name" value="AA9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005103">
        <property type="entry name" value="AA9_LPMO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353:SF19">
        <property type="entry name" value="GLYCOSYLHYDROLASE FAMILY 61-8 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03443">
        <property type="entry name" value="AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="4 5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008058452" description="AA9 family lytic polysaccharide monooxygenase" evidence="6">
        <location>
            <begin position="19"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="Auxiliary Activity family 9 catalytic" evidence="7">
        <location>
            <begin position="19"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU368122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAG08559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="254" mass="27949" checksum="8841214EDC24E5DE" modified="2016-09-07" version="1">MMLTVAIALAALSGTSLAHGGVTSYLIDNKNYTGYVWYDPYESQHDLIQRSWHMNPLSDPASTNLTCNNKGLAVPGTFHASVTAGSTIRATWLTPDGYGWPHTLGPMVAYMASCGEDCTTITDTSSLKWFKIAEEGLRAGYAVGEEDGWYQNDLWENRRTEYWNVTVPAGLKPGRYMIRHEIIMLELNPVQFYPNCAHLEVGGEGDSVPSDEFLVTFPGAYSLKDPGIAISGKVRGDKTTKNYTVPGPKVWKGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CP52</accession>
    <name>A0A177CP52_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1171908</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG09315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039680.1">
        <property type="nucleotide sequence ID" value="XM_018179937.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CP52"/>
    <dbReference type="GeneID" id="28763423"/>
    <dbReference type="InParanoid" id="A0A177CP52"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG09315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="136" mass="15248" checksum="35B2DF1124622C33" modified="2016-09-07" version="1">MFYVVVQIYMSAIGVRVNLYGTLVGVDIVLYNIAFAIGVKLLVNFDCTHRFSLQDVQYASKHMFIFVINRTLRGNIVGSEPRRGPLVGRVLAPLRLPGRLSFVIRELGFYFFVTRLGDIFLVFATSGSFLKSSSST</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CP72</accession>
    <name>A0A177CP72_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TPR-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1234709</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG09323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039688.1">
        <property type="nucleotide sequence ID" value="XM_018183826.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CP72"/>
    <dbReference type="STRING" id="1460663.A0A177CP72"/>
    <dbReference type="GeneID" id="28767312"/>
    <dbReference type="InParanoid" id="A0A177CP72"/>
    <dbReference type="OrthoDB" id="9991317at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.90">
        <property type="entry name" value="Immunodeficiency lentiviruses, gag gene matrix protein p17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024983">
        <property type="entry name" value="CHAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012344">
        <property type="entry name" value="Matrix_HIV/RSV_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19959:SF119">
        <property type="entry name" value="FUNGAL LIPASE-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19959">
        <property type="entry name" value="KINESIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12770">
        <property type="entry name" value="CHAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13374">
        <property type="entry name" value="TPR_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CHAT" evidence="1">
        <location>
            <begin position="871"/>
            <end position="1171"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG09323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="1172" mass="131130" checksum="542549F67C777534" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CPF7</accession>
    <name>A0A177CPF7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1240932</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG09101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039466.1">
        <property type="nucleotide sequence ID" value="XM_018184036.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CPF7"/>
    <dbReference type="STRING" id="1460663.A0A177CPF7"/>
    <dbReference type="GeneID" id="28767522"/>
    <dbReference type="InParanoid" id="A0A177CPF7"/>
    <dbReference type="OrthoDB" id="3945418at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG09101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="162" mass="18289" checksum="B3C65EA5A3A0EAFE" modified="2016-09-07" version="1">MHEVYGPVIRVTPHELHVSEPALYDELYTGTPMKRDQWAWAYNLSLLSGSSWTTIEDSLHRNRRAAVAPSLTLSAIRQFDHVIRAKLELLSQKFERFLTMRSLTKKKNRSDWRCSPTVIHKLLKSDLPAGERTPQRLLAEGISVMMAGATTTAHQNGLSPPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CPH4</accession>
    <name>A0A177CPH4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phosphatidylethanolamine-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1085945</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039217.1">
        <property type="nucleotide sequence ID" value="XM_018174131.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CPH4"/>
    <dbReference type="STRING" id="1460663.A0A177CPH4"/>
    <dbReference type="GeneID" id="28757617"/>
    <dbReference type="InParanoid" id="A0A177CPH4"/>
    <dbReference type="OrthoDB" id="2506647at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030414">
        <property type="term" value="F:peptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030162">
        <property type="term" value="P:regulation of proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046578">
        <property type="term" value="P:regulation of Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00866">
        <property type="entry name" value="PEBP_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.280.10">
        <property type="entry name" value="PEBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008914">
        <property type="entry name" value="PEBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036610">
        <property type="entry name" value="PEBP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035810">
        <property type="entry name" value="PEBP_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11362:SF85">
        <property type="entry name" value="INHIBITOR (TFS1), PUTATIVE (AFU_ORTHOLOGUE AFUA_4G08120)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11362">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01161">
        <property type="entry name" value="PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49777">
        <property type="entry name" value="PEBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG08852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="195" mass="21460" checksum="BF91F05931C5553E" modified="2016-09-07" version="1">MAASIEPSRLLASLSKAALLPSTVIPETFKPSVELSVSFNQKSVVAGNLFRVSEVKEAPTVAFSPESNVPSDATYTLLMIDPDAPTPDDPKFAYWRHWVVTRIPSGATVTAGEALTQYLAPGPKDDSRPHRYLFLLYREPEGKQKLSKEDVGGEEFVERRSFDAREWVGKWGLHLVGVNWMLGAGDGWNGGKDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CPT3</accession>
    <name>A0A177CPT3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">alpha-1,2-Mannosidase</fullName>
            <ecNumber evidence="13">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CC84DRAFT_1160664</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>N(4)-(alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 9A1,2,3B1,2,3) + 4 H2O = N(4)-(alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2) + 4 beta-D-mannose</text>
            <dbReference type="Rhea" id="RHEA:56008"/>
            <dbReference type="Rhea" id="RHEA-COMP:14356"/>
            <dbReference type="Rhea" id="RHEA-COMP:14367"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28563"/>
            <dbReference type="ChEBI" id="CHEBI:59087"/>
            <dbReference type="ChEBI" id="CHEBI:139493"/>
            <dbReference type="EC" id="3.2.1.113"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>N(4)-(alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,3) + 3 H2O = N(4)-(alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2) + 3 beta-D-mannose</text>
            <dbReference type="Rhea" id="RHEA:56028"/>
            <dbReference type="Rhea" id="RHEA-COMP:14358"/>
            <dbReference type="Rhea" id="RHEA-COMP:14367"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28563"/>
            <dbReference type="ChEBI" id="CHEBI:59087"/>
            <dbReference type="ChEBI" id="CHEBI:60628"/>
            <dbReference type="EC" id="3.2.1.113"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the glycosyl hydrolase 47 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="13"/>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG09533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039898.1">
        <property type="nucleotide sequence ID" value="XM_018177550.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CPT3"/>
    <dbReference type="STRING" id="1460663.A0A177CPT3"/>
    <dbReference type="GeneID" id="28761036"/>
    <dbReference type="InParanoid" id="A0A177CPT3"/>
    <dbReference type="OrthoDB" id="8118055at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004571">
        <property type="term" value="F:mannosyl-oligosaccharide 1,2-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.10:FF:000047">
        <property type="entry name" value="Mannosyl-oligosaccharide alpha-1,2-mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001382">
        <property type="entry name" value="Glyco_hydro_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050749">
        <property type="entry name" value="Glycosyl_Hydrolase_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036026">
        <property type="entry name" value="Seven-hairpin_glycosidases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742:SF101">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE ALPHA-1,2-MANNOSIDASE 1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE ALPHA-1,2-MANNOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01532">
        <property type="entry name" value="Glyco_hydro_47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00747">
        <property type="entry name" value="GLYHDRLASE47"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48225">
        <property type="entry name" value="Seven-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0106">Calcium</keyword>
    <keyword evidence="6 12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 13 15" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 14" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008058476" description="alpha-1,2-Mannosidase" evidence="14">
        <location>
            <begin position="21"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="546"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="359"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OAG09533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="559" mass="61797" checksum="6B5CCEAF5DCFF53E" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CQ91</accession>
    <name>A0A177CQ91_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">galacturonan 1,4-alpha-galacturonidase</fullName>
            <ecNumber evidence="11">3.2.1.67</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Galacturan 1,4-alpha-galacturonidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Poly(1,4-alpha-D-galacturonide)galacturonohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">CC84DRAFT_1234978</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>[(1-&gt;4)-alpha-D-galacturonosyl](n) + H2O = alpha-D-galacturonate + [(1-&gt;4)-alpha-D-galacturonosyl](n-1)</text>
            <dbReference type="Rhea" id="RHEA:14117"/>
            <dbReference type="Rhea" id="RHEA-COMP:14570"/>
            <dbReference type="Rhea" id="RHEA-COMP:14572"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58658"/>
            <dbReference type="ChEBI" id="CHEBI:140523"/>
            <dbReference type="EC" id="3.2.1.67"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the glycosyl hydrolase 28 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.67" evidence="11"/>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG09476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039841.1">
        <property type="nucleotide sequence ID" value="XM_018183835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CQ91"/>
    <dbReference type="STRING" id="1460663.A0A177CQ91"/>
    <dbReference type="GeneID" id="28767321"/>
    <dbReference type="InParanoid" id="A0A177CQ91"/>
    <dbReference type="OrthoDB" id="187139at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047911">
        <property type="term" value="F:galacturan 1,4-alpha-galacturonidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004650">
        <property type="term" value="F:polygalacturonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045490">
        <property type="term" value="P:pectin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000743">
        <property type="entry name" value="Glyco_hydro_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31736">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31736:SF14">
        <property type="entry name" value="EXOPOLYGALACTURONASE X-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00295">
        <property type="entry name" value="Glyco_hydro_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 15" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 16" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008058459" description="galacturonan 1,4-alpha-galacturonidase" evidence="16">
        <location>
            <begin position="22"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00041604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00043142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU361169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="OAG09476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="442" mass="48597" checksum="1E6D305E1C1CC8BB" modified="2016-09-07" version="1">MGIFKQPLLATLFLLSLAVQGAFVDERFLSTLRSPRPFHALASQQRNRTCIAPSHGDPSLDDASGILSAIQDCNNGGHVVFAEKLTYTIASPLNLTGLNALDLDIQGTLSFTDNITYWEANSFDLEYQNATSFFALGGKDVHVYGTGEIEGNGQAWWDAYPGNKKLKRPVLFAVVGLEGGSVSQIKLRNAPFWHNIVMESKYIAYSGLDLFSTSNNGNFEKNTDGWDIYRSDNIVIENSTITNGDDCVSFKPNSTNILVQNLRCNGTHGISVGSLGQYPERVDYVENILVRNITMENSSEGARIKVWPDSYSEKSESLTGGGGRGLVRNVTYDGMRLNNVDYGLTITQCYGQDDEEECFKHPSKLNITDVTFRNIRGRTNRVFSPIVGHLVCSSPYTCSGILAENVDIRTINGSNLVTCRNLDTKSLGGLNCTEWSKGYNPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CQB8</accession>
    <name>A0A177CQB8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_452508</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG09714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040079.1">
        <property type="nucleotide sequence ID" value="XM_018186320.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CQB8"/>
    <dbReference type="GeneID" id="28769806"/>
    <dbReference type="InParanoid" id="A0A177CQB8"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG09714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="84" mass="9162" checksum="915EEF1F31C1045A" modified="2016-09-07" version="1">MALRIGLASTSDALRPMLAAWDAAYSWIRFAGALVPFGPLCERDRAVGWVPEDIIIIIIIITILIIDEGAVYVWRGGCEFGRAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CQD1</accession>
    <name>A0A177CQD1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1204305</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG09152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039517.1">
        <property type="nucleotide sequence ID" value="XM_018181893.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CQD1"/>
    <dbReference type="GeneID" id="28765379"/>
    <dbReference type="InParanoid" id="A0A177CQD1"/>
    <dbReference type="OrthoDB" id="5413827at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38790:SF4">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38790">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG09152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="217" mass="24644" checksum="AF537D87AD8B20F0" modified="2016-09-07" version="1">MNDCSRTVLHVPVETHVCSEQSRAASSPFPRLSVLANDMLSLEHTPTHLVHVVQRNAETLLLQLPPEIRNKIFRDALAGLKVEVRAFMAAPRLYRVGPSNDYKSPSANLSLLQVCRQIYNETATLVCSGDTLFTAVTFSDLKMLHNKLNMAQRERLASLRLSTPCMIQIDALKVQLIDMFRGLRRVELCYWEGMVDLAERVKHEQQRSGLEILIAYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CQN6</accession>
    <name>A0A177CQN6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1160462</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG09268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039633.1">
        <property type="nucleotide sequence ID" value="XM_018177505.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CQN6"/>
    <dbReference type="GeneID" id="28760991"/>
    <dbReference type="InParanoid" id="A0A177CQN6"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG09268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="56" mass="6369" checksum="B6FD8349A83D43E3" modified="2016-09-07" version="1">MPELQPQIQRLLNLSIACALISTFSIVIRIYCKIRNKGGFHTGCLFKKESSWDADN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CQS0</accession>
    <name>A0A177CQS0_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Invertebrate defensins family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1257823</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG09107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039472.1">
        <property type="nucleotide sequence ID" value="XM_018184766.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CQS0"/>
    <dbReference type="GeneID" id="28768252"/>
    <dbReference type="InParanoid" id="A0A177CQS0"/>
    <dbReference type="OrthoDB" id="3784319at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008058482" description="Invertebrate defensins family profile domain-containing protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG09107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="65" mass="6728" checksum="D6243D2C6C925BA4" modified="2016-09-07" version="1">MKIVFTAVFALFATVMAAPSVENVGAAESLVEKRCLGAGAETSNFNDCCSGQGYADRGCACTRCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CR01</accession>
    <name>A0A177CR01_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Integral membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1171973</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG09388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039753.1">
        <property type="nucleotide sequence ID" value="XM_018179945.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CR01"/>
    <dbReference type="STRING" id="1460663.A0A177CR01"/>
    <dbReference type="GeneID" id="28763431"/>
    <dbReference type="InParanoid" id="A0A177CR01"/>
    <dbReference type="OrthoDB" id="2603at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="145"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="169"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="212"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="364"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="392"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="431"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG09388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="507" mass="56616" checksum="B8E0DEDC553A778D" modified="2016-09-07" version="1">MTSGNAFGMPDFEDEESRARMESDAGPNDVGHDHIVFQVPDFDGEHHQEHPHPKHALSEGAGVPPESTANNVRIANRVDGDTNFLGAHNGDKRSNSQAKNDMLAHSPSLGLIPTQSIEEGEAHKFVKKRTYLHKKHSERIRRHTFLAKCLGVVQNIWIMVSTFPYWDMAFWSGFAYAVGSAMFIIDGAFAFGPLASPNKHWPKGEDKYGGPILFFLGAVICYQTGAVMAYLEAINDGCFAGVAMKRFWVEGSEEDKKKLLDAKLHTFFGHIIPHHHHHDTDDAHANDIVGEKSRADVGGEQDVEAMWQTATSHDPEAQIHPIQPAPSRRQAVDHGPADQESFNEYMSWRWWPTWHALSTYHVRATLYGVTGIVVLPGVLSSLAWWQKIAAFWVPQVVASVCFLTAAIMFTLESQDVWYKPLPWTVRWWIGGWAAIGSVGFLLCACFGLGSEKHTWCEYQSDLSSMWGSAAYLFSSLLQWYEAVSDGPVLAFPNNRTPVLMRKAKVAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CR80</accession>
    <name>A0A177CR80_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1081557</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG09279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039644.1">
        <property type="nucleotide sequence ID" value="XM_018173932.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CR80"/>
    <dbReference type="STRING" id="1460663.A0A177CR80"/>
    <dbReference type="GeneID" id="28757418"/>
    <dbReference type="InParanoid" id="A0A177CR80"/>
    <dbReference type="OrthoDB" id="3763345at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG09279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="135" mass="15369" checksum="C0FEF7F2BEF2DA79" modified="2016-09-07" version="1" fragment="single">RGDLFAKGRLKNPYIFRRNIVTIFGGPKDSKFDSEDMKIRKESTRDRCELIRGLSADGVISWAIAYPPTLWAAGSMALDVFTCLLDDIEPELEQAWPPTVWETLHLLKADEGFLESSLVYEEFLEGLFSKLLKIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CT29</accession>
    <name>A0A177CT29_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_1256469</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041059.1">
        <property type="nucleotide sequence ID" value="XM_018184628.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CT29"/>
    <dbReference type="STRING" id="1460663.A0A177CT29"/>
    <dbReference type="GeneID" id="28768114"/>
    <dbReference type="InParanoid" id="A0A177CT29"/>
    <dbReference type="OrthoDB" id="10253736at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43391:SF14">
        <property type="entry name" value="DEHYDROGENASE_REDUCTASE SDR FAMILY PROTEIN 7-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43391">
        <property type="entry name" value="RETINOL DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAG10694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="266" mass="28648" checksum="732E07842B0D7026" modified="2016-09-07" version="1">MKDIASKTALITGGGTGIGLALALQLAAEGANIIISSTSKERLAAGAQKIREACPNVKVLDIVCDVSDRQSIKQLKDEITKAGLQVDILVCNAGVTTSGDYHLHREEDWDWVYGVVLNGTTYCIQAFYPDMVARGSGHIVINGSQAGMVPNWVSLHGPYTSAKAAVHALGAAMRPEAATHGVGVTTVVIAGTQTEIMKSERSRPERFGEPLNVKVERRAARRVPPSEVAEKIVTGIKEDRGWVATHPDLKDRTKQYFDEILAAYDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CT90</accession>
    <name>A0A177CT90_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ankyrin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_1065126</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041119.1">
        <property type="nucleotide sequence ID" value="XM_018173625.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CT90"/>
    <dbReference type="STRING" id="1460663.A0A177CT90"/>
    <dbReference type="GeneID" id="28757111"/>
    <dbReference type="InParanoid" id="A0A177CT90"/>
    <dbReference type="OrthoDB" id="4772757at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0085020">
        <property type="term" value="P:protein K6-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171:SF11">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="31"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAG10754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="84" mass="8784" checksum="EE32647BCC37DB80" modified="2016-09-07" version="1" fragment="single">QAAAMKGHAQVVETLLDRGAEVNAQVGFYANALQVAASEGHAQVVQILLDRGAEINAQGGYFGSALQAASYGRHQHVVKILLAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CTN3</accession>
    <name>A0A177CTN3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative gibberellin 20-oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CC84DRAFT_1112080</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040474.1">
        <property type="nucleotide sequence ID" value="XM_018175309.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CTN3"/>
    <dbReference type="STRING" id="1460663.A0A177CTN3"/>
    <dbReference type="GeneID" id="28758795"/>
    <dbReference type="InParanoid" id="A0A177CTN3"/>
    <dbReference type="OrthoDB" id="288590at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044283">
        <property type="term" value="P:small molecule biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050231">
        <property type="entry name" value="Iron_ascorbate_oxido_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47990">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00682">
        <property type="entry name" value="IPNSYNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="4">
        <location>
            <begin position="182"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="140"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAG10109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="345" mass="38153" checksum="0314548ADA1000F5" modified="2016-09-07" version="1">MSTVFSSLPVVDIHNLKASTLDTADHQALSRKLYDALSTTGFAYIKNAPLSFGQDEIFELSRDFFALPLSQKMKLAKKSFRQSHTNTYRGYFPTQPHLTPDNLKEGFEIGNPAADHNKATPAKAQKINLSESNVWPDAQLFAKQERLEQIYNELQRLAANLLSLLAAPLGKDPNFFSSWIDDSLSTLRLLHYPPVAQTVSPGTKHAEQAVRLSCTPHTDSGILTLLHQDATGGLEVLNAAGEWIPAPYIPGSIVVNIGDLMARVSGSRFKATMHRVRAPLPNPDAADARFGRFSIPFFFEPGEVCSVSIEGEEDSIVYGDYLRRKMATFVEFQEDSGYDTGTTEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CTW9</accession>
    <name>A0A177CTW9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">GroES-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_1237682</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041061.1">
        <property type="nucleotide sequence ID" value="XM_018183913.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CTW9"/>
    <dbReference type="STRING" id="1460663.A0A177CTW9"/>
    <dbReference type="GeneID" id="28767399"/>
    <dbReference type="InParanoid" id="A0A177CTW9"/>
    <dbReference type="OrthoDB" id="1879366at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000039">
        <property type="entry name" value="Alcohol dehydrogenase AdhP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940:SF8">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="7">
        <location>
            <begin position="9"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAG10696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="343" mass="36766" checksum="554089876BED3131" modified="2016-09-07" version="1">MKAAQWDPAQQKVVVNEVPKPTPGPGQFLVRLASASLCHSDLMSMAMPHEKPITIGHEGAGYIEEIHSTAENKGFKVGDGIGFTYIVNYCDDCEGCAVHNNHCLTKKSRVHGFDEPGLFAEYAAVDATSCIILPQELSPETSSPIFCGGITAFHCVDSCELKPGQWLAIIGCGGLGQLAVQYAKAMGFKVIGIDINDDILSTAKSQGADAVFNSRSNPNFFEEAKAVMNRGPNKGADAVAVFSAATAAYKSAPPLVKLGGIIMVVGLPAAGVTFDALDIARGTYRVKGDSTGVPKRMKKAIDFTAKHRIKPEIEIHKSLDAVNEMVERMKKGELTRRQLVQFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CU47</accession>
    <name>A0A177CU47_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_518360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG11065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041430.1">
        <property type="nucleotide sequence ID" value="XM_018186584.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CU47"/>
    <dbReference type="GeneID" id="28770070"/>
    <dbReference type="InParanoid" id="A0A177CU47"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG11065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="66" mass="6959" checksum="55726D6FD928CB7A" modified="2016-09-07" version="1">MGLVLAHESFSRSACVEARQTRGGKKRAGPHPSSPRTLPVRTGERGTSESRANVYIGGSHERGGGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CWM4</accession>
    <name>A0A177CWM4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_62296</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG11945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042310.1">
        <property type="nucleotide sequence ID" value="XM_018186928.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CWM4"/>
    <dbReference type="GeneID" id="28770414"/>
    <dbReference type="InParanoid" id="A0A177CWM4"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG11945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="167" mass="18919" checksum="C8073FADD9834246" modified="2016-09-07" version="1">MWVLSVLFDTRMSGTCELRSVSSLQPLFCWINFGHIGRVFPSQPVSSWCIWVLVRFASAHHAKLYGPAIVQTSITPFASVSGHVMSAPGGIELRVVRQGVQTWVSPPCRSRRPAYAKSASCGSRNDELGSWRQRMMSAKHRNIVQLSWSERPSFDDHNFAFRIVRPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CXF2</accession>
    <name>A0A177CXF2_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phosphatidate phosphatase APP1 catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_1107067</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG11507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041872.1">
        <property type="nucleotide sequence ID" value="XM_018175163.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CXF2"/>
    <dbReference type="STRING" id="1460663.A0A177CXF2"/>
    <dbReference type="GeneID" id="28758649"/>
    <dbReference type="InParanoid" id="A0A177CXF2"/>
    <dbReference type="OrthoDB" id="414243at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008195">
        <property type="term" value="F:phosphatidate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019236">
        <property type="entry name" value="APP1_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052935">
        <property type="entry name" value="Mg2+_PAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28208">
        <property type="entry name" value="PHOSPHATIDATE PHOSPHATASE APP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28208:SF2">
        <property type="entry name" value="PHOSPHATIDATE PHOSPHATASE APP1 CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09949">
        <property type="entry name" value="APP1_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008058713" description="Phosphatidate phosphatase APP1 catalytic domain-containing protein" evidence="2">
        <location>
            <begin position="22"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidate phosphatase APP1 catalytic" evidence="3">
        <location>
            <begin position="288"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="202"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAG11507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="525" mass="57604" checksum="89EDB9E7360007CB" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CXQ3</accession>
    <name>A0A177CXQ3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_112061</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042678.1">
        <property type="nucleotide sequence ID" value="XM_018175581.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CXQ3"/>
    <dbReference type="STRING" id="1460663.A0A177CXQ3"/>
    <dbReference type="GeneID" id="28759067"/>
    <dbReference type="InParanoid" id="A0A177CXQ3"/>
    <dbReference type="OrthoDB" id="3797976at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540">
        <property type="entry name" value="TRANSCRIPTION FACTOR (ACR-2), PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540:SF5">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG12313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="288" mass="32121" checksum="340BC2EE9FE0FBB0" modified="2016-09-07" version="1">MLGDVHNDTFIVVSDPTIANALDSQGSLQKARSHAARAAHARKRIARTAEYNARKPIEATLAYRQDQHGNTRELVTRLQLQTAPSPLGIMCADRRDPFNSVAAHLSHIEYFLLDHYAQVVVPTLNIQCRSLKNLGESAERMLREWVHLALTDAVVLQGVLLAACRHLIGRGYQAWKFEELAAGYKVRCVRDVIDAIESKDMDMDVTFAKIFTLANDEIWLGNLDMFRRHAAGAIKMVVLHGGPERLGLNGYLNSLFKIVLDKDHALRGDPRACTGFDRINRGVCLSAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CXW3</accession>
    <name>A0A177CXW3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Acetyl-CoA synthetase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CC84DRAFT_1078863</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Siderophore biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042738.1">
        <property type="nucleotide sequence ID" value="XM_018173814.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CXW3"/>
    <dbReference type="STRING" id="1460663.A0A177CXW3"/>
    <dbReference type="GeneID" id="28757300"/>
    <dbReference type="InParanoid" id="A0A177CXW3"/>
    <dbReference type="OrthoDB" id="10253115at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031956">
        <property type="term" value="F:medium-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12780:FF:000003">
        <property type="entry name" value="Long-chain-fatty-acid--CoA ligase FadD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201:SF6">
        <property type="entry name" value="ACYL COA SYNTHETASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201">
        <property type="entry name" value="ACYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="3">
        <location>
            <begin position="55"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="4">
        <location>
            <begin position="489"/>
            <end position="570"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAG12373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="588" mass="65381" checksum="82EECA8F5FBE7FD1" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CXY1</accession>
    <name>A0A177CXY1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Acyl-CoA dehydrogenase/oxidase C-terminal</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CC84DRAFT_48668</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG11752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042117.1">
        <property type="nucleotide sequence ID" value="XM_018186472.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CXY1"/>
    <dbReference type="STRING" id="1460663.A0A177CXY1"/>
    <dbReference type="GeneID" id="28769958"/>
    <dbReference type="InParanoid" id="A0A177CXY1"/>
    <dbReference type="OrthoDB" id="10251155at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052904">
        <property type="entry name" value="Acyl-CoA_dehydrogenase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041504">
        <property type="entry name" value="AidB_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42707:SF2">
        <property type="entry name" value="ACD11 DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42707">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18158">
        <property type="entry name" value="AidB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0274">FAD</keyword>
    <keyword evidence="2 4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Adaptive response protein AidB N-terminal" evidence="8">
        <location>
            <begin position="49"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="7">
        <location>
            <begin position="216"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="6">
        <location>
            <begin position="352"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF18158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAG11752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="668" mass="73301" checksum="7E3DBC90D19E981A" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CZ64</accession>
    <name>A0A177CZ64_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">U1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CC84DRAFT_1160050</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018043158.1">
        <property type="nucleotide sequence ID" value="XM_018177391.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CZ64"/>
    <dbReference type="STRING" id="1460663.A0A177CZ64"/>
    <dbReference type="GeneID" id="28760877"/>
    <dbReference type="InParanoid" id="A0A177CZ64"/>
    <dbReference type="OrthoDB" id="191651at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013085">
        <property type="entry name" value="U1-CZ_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040023">
        <property type="entry name" value="WBP4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13173">
        <property type="entry name" value="WW DOMAIN BINDING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13173:SF10">
        <property type="entry name" value="WW DOMAIN-BINDING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06220">
        <property type="entry name" value="zf-U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="U1-type" evidence="5">
        <location>
            <begin position="8"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="28"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="203"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="73"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="91"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="206"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="242"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAG12793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="281" mass="31483" checksum="C6356CD92C5CE159" modified="2016-09-07" version="1">MSEYWKSTPKYWCKFCKDYVKDTKFERQQHEATGRHQSNIQRSLKGLHREQAAEERQKQRAKDEVARLNGLVPSTSSSAASNAPAKPTFAKTEEKKATLQDRKKQWEQLAAMGIAVPDEARGGMALKGEWTVVKEEVVGSVDQDGEFKALNKGVRKRKVDEAEEERELAGETITRKKGWGQTFKSLPGKAGDDDDIEALFKKRKADVKDEEPALKTEVKEEDTVKGEAESQPLADIPTEEEAAAKREAERKTDSTAALVKEEESSGSTPAVVFKKRKKMAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177D008</accession>
    <name>A0A177D008_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DUF202 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CC84DRAFT_163222</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018043241.1">
        <property type="nucleotide sequence ID" value="XM_018185433.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177D008"/>
    <dbReference type="GeneID" id="28768919"/>
    <dbReference type="InParanoid" id="A0A177D008"/>
    <dbReference type="OrthoDB" id="5525680at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003807">
        <property type="entry name" value="DUF202"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052053">
        <property type="entry name" value="IM_YidH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34187:SF3">
        <property type="entry name" value="DUF DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G11150)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34187">
        <property type="entry name" value="FGR18P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02656">
        <property type="entry name" value="DUF202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="80"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="109"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="152"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="DUF202" evidence="6">
        <location>
            <begin position="65"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAG12876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="178" mass="20285" checksum="AC4C97C63EAE7F7E" modified="2016-09-07" version="1">MDFRPLDRMLDTDESITDEPFRPFYNFWAPKPVIVHQDNEYDGAVFIERPWLGVLLFDNIASDARDHAANERTFLSWLRLSVYMAIVAVAIILNFHLKSEPTAVERRISLPFGIIFWILSVACLVSGLANYIKTVARYSRRAALVQAGWKTQAMFTVVATTIVAACILFLSTNAQNRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177D0F7</accession>
    <name>A0A177D0F7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MT-A70-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1160253</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MT-A70-like family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG13006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018043371.1">
        <property type="nucleotide sequence ID" value="XM_018177454.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177D0F7"/>
    <dbReference type="STRING" id="1460663.A0A177D0F7"/>
    <dbReference type="GeneID" id="28760940"/>
    <dbReference type="InParanoid" id="A0A177D0F7"/>
    <dbReference type="OrthoDB" id="61116at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007757">
        <property type="entry name" value="MT-A70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12829:SF4">
        <property type="entry name" value="N(6)-ADENINE-SPECIFIC METHYLTRANSFERASE METTL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12829">
        <property type="entry name" value="N6-ADENOSINE-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05063">
        <property type="entry name" value="MT-A70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51143">
        <property type="entry name" value="MT_A70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="179"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG13006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="449" mass="51238" checksum="46BFA701EDB52C77" modified="2016-09-07" version="1">MQGLKDEMQPNTAILFQNADRDVTLIDIPKSIAMAQGRSDTLLSTAPLEAPYQLHEEPKTSQAKKNHSSHFTDLHIEYRSTIHAALAEIRSHTSGPWCLPRKLMTQLPKHGEMQLDDPEKEIESRLHEWSALAESKEEDTHFDFQKMMASISATPDPNATDIEAVSHKWLMSYTPPRDDAQIQSNQASEPWKSSFHNPEDHPLDIHVREGVTQAGREAPAYRFTIPPHATFFLGDSTHSDMFRASFRQLTDDYVLPRHFDLVLLDPPWPNRSAKRKGAYEQAGGMRHMKKVLLGMDIDSYLEHNALVGVWITNKEAMRTQVLGPGGLFETWNVGLVEEWIWVKVTTSGEPMFDIDSALRKPYEVLLLGRAAPNAWTTMSHARVTKRKIIAAVPDVHSRKPCLKELLEPYMPDARKYSALEVFSRHLVVGWTSWGNEVIKYNWDRYWALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177D0G0</accession>
    <name>A0A177D0G0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1228224</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG13185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018043550.1">
        <property type="nucleotide sequence ID" value="XM_018183630.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177D0G0"/>
    <dbReference type="GeneID" id="28767116"/>
    <dbReference type="InParanoid" id="A0A177D0G0"/>
    <dbReference type="OrthoDB" id="3794448at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008058836" evidence="1">
        <location>
            <begin position="19"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG13185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="163" mass="17698" checksum="D9D895A15A03FF5B" modified="2016-09-07" version="1">MKYSRSVISALFAASVLAAPVPAPGTEDSSVDNAFVNVAYYGLKEREAAAKPEPESATVDADFIGIVYNGLKKREEEKASVDSAFVNVAYYGLKEREAAEQAKRGEEQPDVDSAFVNVAYFGLKEREAAEAVAKRNEESSDVHSAFVNVAYYGLKERDSEVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177D199</accession>
    <name>A0A177D199_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Dimethylglycine dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CC84DRAFT_1160068</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GcvT family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018043174.1">
        <property type="nucleotide sequence ID" value="XM_018177396.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177D199"/>
    <dbReference type="STRING" id="1460663.A0A177D199"/>
    <dbReference type="GeneID" id="28760882"/>
    <dbReference type="InParanoid" id="A0A177D199"/>
    <dbReference type="OrthoDB" id="498204at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.110">
        <property type="entry name" value="Aminomethyltransferase beta-barrel domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1400">
        <property type="entry name" value="Aminomethyltransferase beta-barrel domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.120">
        <property type="entry name" value="Probable tRNA modification gtpase trme, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032503">
        <property type="entry name" value="FAO_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028896">
        <property type="entry name" value="GcvT/YgfZ/DmdA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029043">
        <property type="entry name" value="GcvT/YgfZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013977">
        <property type="entry name" value="GcvT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006222">
        <property type="entry name" value="GCVT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027266">
        <property type="entry name" value="TrmE/GcvT-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43757">
        <property type="entry name" value="AMINOMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43757:SF11">
        <property type="entry name" value="SARCOSINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16350">
        <property type="entry name" value="FAO_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01571">
        <property type="entry name" value="GCV_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08669">
        <property type="entry name" value="GCV_T_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101790">
        <property type="entry name" value="Aminomethyltransferase beta-barrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103025">
        <property type="entry name" value="Folate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="2">
        <location>
            <begin position="6"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="FAD dependent oxidoreductase central" evidence="5">
        <location>
            <begin position="302"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="GCVT N-terminal" evidence="3">
        <location>
            <begin position="362"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="domain" description="Aminomethyltransferase C-terminal" evidence="4">
        <location>
            <begin position="667"/>
            <end position="745"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAG12809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="770" mass="84504" checksum="CDD23F5877C0BC61" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177D1J7</accession>
    <name>A0A177D1J7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ankyrin repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_1136227</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG13000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018043365.1">
        <property type="nucleotide sequence ID" value="XM_018176091.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177D1J7"/>
    <dbReference type="FunCoup" id="A0A177D1J7">
        <property type="interactions" value="160"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177D1J7"/>
    <dbReference type="GeneID" id="28759577"/>
    <dbReference type="InParanoid" id="A0A177D1J7"/>
    <dbReference type="OrthoDB" id="539213at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904855">
        <property type="term" value="F:proteasome regulatory particle binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044183">
        <property type="term" value="F:protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070682">
        <property type="term" value="P:proteasome regulatory particle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="73"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="107"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="174"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAG13000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="236" mass="25566" checksum="F5E4519B8CB2C8BE" modified="2016-09-07" version="1">MDDARLKFAIHEACREGQTSKVESLLSANPKLASLRDDDDRLPIHWAVSYNHLPIVQLLVQSKSFDPDVVDGSGWTPLMMACSRKEADAIVSLLISKDADVNAKNSNGQTALHFCASKNHLDLARTLLKEKATARVKDKRGQLPLHRAAAIGSVPMIKELLGPGKSPLNATDADGWTALHHAIAEGHGDAALLLLTGGAEFDKKNSSDQVALDLVPDEKTRKFILQAAEREGIDLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BUB7</accession>
    <name>A0A177BUB7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Glucose-methanol-choline oxidoreductase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_415273</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441563">
        <property type="protein sequence ID" value="OAF99042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029408.1">
        <property type="nucleotide sequence ID" value="XM_018186120.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BUB7"/>
    <dbReference type="STRING" id="1460663.A0A177BUB7"/>
    <dbReference type="GeneID" id="28769606"/>
    <dbReference type="InParanoid" id="A0A177BUB7"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF147">
        <property type="entry name" value="CHOLINE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008057325" evidence="6">
        <location>
            <begin position="21"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="7">
        <location>
            <begin position="328"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="278"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="567"/>
            <end position="568"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAF99042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="644" mass="70044" checksum="EB12A03FAD211922" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BUD8</accession>
    <name>A0A177BUD8_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1234364</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441566">
        <property type="protein sequence ID" value="OAF98590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018028956.1">
        <property type="nucleotide sequence ID" value="XM_018183816.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BUD8"/>
    <dbReference type="GeneID" id="28767302"/>
    <dbReference type="InParanoid" id="A0A177BUD8"/>
    <dbReference type="OrthoDB" id="265717at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF64">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26639">
        <property type="entry name" value="Het-6_barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="2">
        <location>
            <begin position="108"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAF98590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="797" mass="90855" checksum="C02DD47491857C73" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BUX3</accession>
    <name>A0A177BUX3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CBM21 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_389494</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441562">
        <property type="protein sequence ID" value="OAF99273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029639.1">
        <property type="nucleotide sequence ID" value="XM_018186012.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BUX3"/>
    <dbReference type="STRING" id="1460663.A0A177BUX3"/>
    <dbReference type="GeneID" id="28769498"/>
    <dbReference type="InParanoid" id="A0A177BUX3"/>
    <dbReference type="OrthoDB" id="1881at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000164">
        <property type="term" value="C:protein phosphatase type 1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001069">
        <property type="term" value="F:glycogen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008157">
        <property type="term" value="F:protein phosphatase 1 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005979">
        <property type="term" value="P:regulation of glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2440">
        <property type="entry name" value="Carbohydrate binding type-21 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005036">
        <property type="entry name" value="CBM21_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038175">
        <property type="entry name" value="CBM21_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050782">
        <property type="entry name" value="PP1_regulatory_subunit_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12307:SF36">
        <property type="entry name" value="GLYCOGEN-BINDING SUBUNIT 76A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12307">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03370">
        <property type="entry name" value="CBM_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51159">
        <property type="entry name" value="CBM21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBM21" evidence="2">
        <location>
            <begin position="321"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="435"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="548"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="562"/>
            <end position="572"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAF99273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="618" mass="67926" checksum="F3EB492F2DAC56BD" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BVM5</accession>
    <name>A0A177BVM5_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1169072</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441561">
        <property type="protein sequence ID" value="OAF99533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029899.1">
        <property type="nucleotide sequence ID" value="XM_018179568.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BVM5"/>
    <dbReference type="STRING" id="1460663.A0A177BVM5"/>
    <dbReference type="GeneID" id="28763054"/>
    <dbReference type="InParanoid" id="A0A177BVM5"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF50">
        <property type="entry name" value="METHYLTRANSFERASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransferase" evidence="2">
        <location>
            <begin position="83"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="294"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="302"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAF99533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="388" mass="43313" checksum="2218A5D66317F976" modified="2016-09-07" version="1">MDATRGSVSSASVAQSTKLEDSAIFANPFALRHGRRYLRDLPYPLPCDLPELQRQNLHTLLSTSVFGRALGSSPNPERPPHKVLEIACGSGYWSSLCHEYLYGLGYEDVQYTGLDIVPVAADLRKQNIDWRFVQHDLRKVPLPFDDGEFDIVVMKDMSMVVPLGSASQRVLDEAIRILKSGGTLEIWETDHVIRSILPHPPPPPGKNPQEYACAVATGTFMISPITPFTEVHNKFLASSNNWITEALDKRKLSPTPCVRISQMLLQETETLQGVENRRVAIPLGELRWEREAAAERQAANRRGSEAARTKKSGDSATLTDEQAALRHTALLVVIQMIESLEPLLKEVSGKSQEEWQTWWGSMMTNLLQEKGASSGECLEIGVWWCQKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BWB1</accession>
    <name>A0A177BWB1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Ubiquitin-conjugating enzyme E2 Z</fullName>
            <ecNumber evidence="3">2.3.2.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">E2 ubiquitin-conjugating enzyme Z</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Ubiquitin carrier protein Z</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Ubiquitin-protein ligase Z</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CC84DRAFT_1169686</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.3.2.23" evidence="3"/>
    <dbReference type="EMBL" id="KV441563">
        <property type="protein sequence ID" value="OAF98958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029324.1">
        <property type="nucleotide sequence ID" value="XM_018179725.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BWB1"/>
    <dbReference type="STRING" id="1460663.A0A177BWB1"/>
    <dbReference type="GeneID" id="28763211"/>
    <dbReference type="InParanoid" id="A0A177BWB1"/>
    <dbReference type="OrthoDB" id="1926878at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004869">
        <property type="term" value="F:cysteine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043066">
        <property type="term" value="P:negative regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23809">
        <property type="entry name" value="UBCc_UBE2Z"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00195">
        <property type="entry name" value="UBCc_UEV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000126">
        <property type="entry name" value="Ubiquitin conjugating enzyme, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46116">
        <property type="entry name" value="(E3-INDEPENDENT) E2 UBIQUITIN-CONJUGATING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46116:SF26">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2 Z"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="15">
        <location>
            <begin position="4"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="UBC core" evidence="15">
        <location>
            <begin position="287"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00039894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00041798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00042316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00042401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OAF98958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="442" mass="50773" checksum="F32831383305613F" modified="2016-09-07" version="1">MSNQSILRITRELSEIQRGSDLSLAVACRDIDVRHVRALIIGPPDTPYEFGFFEFTAKFTKEYPTKAPHVQCITTNGGHTRFNPNIYAGGKVCLSILGTWRGERGEEWSSAQGLESILISIQSLMSTNPYENEPGFEDAKSDYDKKNQAAYVAKIRHETLRISVIERLEDYLGIKRGKPSQVTVYNAEEDYQSGAGDAPFEPFKDLCKRRFLWYYESYLASIDAEMKKHREGERFEKMPFEGPGNTMEGIFQYPQLKERLQTILAKLNEETLGWATEGMRAVEKEMGIASNLQRQFEQIVENYKKNDAVTLDLDLVDKNPFVWRLLFFGRPMTHLDGGMFRIIIHVSPKFPDVLPRVKFDTPIFHHRVSPDGVLCYNATRKDDMRSHIEAIIEAIEEESPAYDPRTLVNLEAAKLFWGGPDQKKLYNRRLRRSAQDSAENCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BWV2</accession>
    <name>A0A177BWV2_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Extracelular serine carboxypeptidase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CC84DRAFT_351898</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S28 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441560">
        <property type="protein sequence ID" value="OAF99973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030339.1">
        <property type="nucleotide sequence ID" value="XM_018185878.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BWV2"/>
    <dbReference type="GeneID" id="28769364"/>
    <dbReference type="InParanoid" id="A0A177BWV2"/>
    <dbReference type="OrthoDB" id="1735038at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070008">
        <property type="term" value="F:serine-type exopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008758">
        <property type="entry name" value="Peptidase_S28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11010">
        <property type="entry name" value="PROTEASE S28 PRO-X CARBOXYPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11010:SF117">
        <property type="entry name" value="SERINE PROTEASE 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05577">
        <property type="entry name" value="Peptidase_S28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008057404" description="Extracelular serine carboxypeptidase-like protein" evidence="6">
        <location>
            <begin position="20"/>
            <end position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAF99973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="538" mass="59256" checksum="BF520AE49C44520B" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BXY5</accession>
    <name>A0A177BXY5_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">glucan endo-1,6-beta-glucosidase</fullName>
            <ecNumber evidence="13">3.2.1.75</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Beta-1,6-glucanase B</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Endo-1,6-beta-D-glucanase B</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Endo-1,6-beta-glucanase B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">CC84DRAFT_1231880</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Beta-glucanases participate in the metabolism of beta-glucan, the main structural component of the cell wall. Acts on lutean, pustulan and 1,6-oligo-beta-D-glucosides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>Random hydrolysis of (1-&gt;6)-linkages in (1-&gt;6)-beta-D-glucans.</text>
            <dbReference type="EC" id="3.2.1.75"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 17">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.75" evidence="13"/>
    <dbReference type="EMBL" id="KV441561">
        <property type="protein sequence ID" value="OAF99561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029927.1">
        <property type="nucleotide sequence ID" value="XM_018183742.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BXY5"/>
    <dbReference type="STRING" id="1460663.A0A177BXY5"/>
    <dbReference type="GeneID" id="28767228"/>
    <dbReference type="InParanoid" id="A0A177BXY5"/>
    <dbReference type="OrthoDB" id="1887033at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046557">
        <property type="term" value="F:glucan endo-1,6-beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004338">
        <property type="term" value="F:glucan exo-1,3-beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050386">
        <property type="entry name" value="Glycosyl_hydrolase_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297">
        <property type="entry name" value="GLUCAN ENDO-1,6-BETA-GLUCOSIDASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297:SF39">
        <property type="entry name" value="GLUCAN ENDO-1,6-BETA-GLUCOSIDASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 17" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 17 20" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 18" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008057452" description="glucan endo-1,6-beta-glucosidase" evidence="18">
        <location>
            <begin position="18"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 5" evidence="19">
        <location>
            <begin position="101"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00036633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00037628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00041472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00042025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00043257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU361153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="OAF99561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="452" mass="50469" checksum="F85753EC1B646947" modified="2016-09-07" version="1">MRWSTLLPVLLAASAHAWMPQDRNLAAFNRNYNAHGKRVAALPNKIRGVNLGGWLVSEPWLMKNEWTQVIGCPACSDCNSNGGKCSEFDCVSAIGQSAADSGFNKHYTGWITPADIQDIHDAGLNTIRIPIGYWSLRELVDSSEHFPNMGDLKYLDAVIQKAADLGMFVVMDLHAAPGAQKTNDAFTGQCLPPAWLPGFFIQRNYDRASKWLSWMTQRIHNTPSYAQTVGIIEVVNEPQSSREGMPAEEVNTFTQVYYPQALKAVRDAEAALNVPASDRLHVQFMDKLWSSGDPKAHLPSDSAIIFDDHNYVGGAVGAISHPGKPQDVKQADYMWYTCYTDDRLSDGDVPKVVQEFSLTVDGAVEGNNEFAWDASQNQAFYTQWWNAQQRLYEQTNGWIFWTWKVGNELNNPRWSYQQAVARKWIPGSAAGLEGTRANDVCKTYFGTSDGRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BYT7</accession>
    <name>A0A177BYT7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_294631</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441559">
        <property type="protein sequence ID" value="OAG00316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030681.1">
        <property type="nucleotide sequence ID" value="XM_018185774.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BYT7"/>
    <dbReference type="STRING" id="1460663.A0A177BYT7"/>
    <dbReference type="GeneID" id="28769260"/>
    <dbReference type="InParanoid" id="A0A177BYT7"/>
    <dbReference type="OrthoDB" id="256333at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000039">
        <property type="entry name" value="Alcohol dehydrogenase AdhP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940:SF8">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="7">
        <location>
            <begin position="8"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAG00316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="313" mass="32579" checksum="594F17195ECA3442" modified="2016-09-07" version="1">MVQHGIMGTKLPCTGSHEGSGTVVAVGSSVKNFKVGDRVMGGIIYHSCGTCGDCRGPETSTQYCTNAAYCGVKGADGYFAEYARIDSRWAAKLPDKVSFETAAPLACAGCTVYKGVVLAGLKKGEWIALVGSGGGLGHLGVQFAKALGLKVVGVDARDEGLELTRKGGADLVVDARKGDEAAVKEVKHVTNGEGVAATVNVSDAKTAAATSCAITRMHGTVVQVAQPDNVTIPFQELIFRDIRLRGSLICSAQEANDMLQLVSKHNISVNANAFKGLGDMEKLIELAESGKMKGKGIVIMDQSQIDAEGKGVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BZN8</accession>
    <name>A0A177BZN8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CC84DRAFT_1103057</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441560">
        <property type="protein sequence ID" value="OAF99906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030272.1">
        <property type="nucleotide sequence ID" value="XM_018174995.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BZN8"/>
    <dbReference type="GeneID" id="28758481"/>
    <dbReference type="InParanoid" id="A0A177BZN8"/>
    <dbReference type="OrthoDB" id="413079at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000286">
        <property type="entry name" value="MFS efflux transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051788">
        <property type="entry name" value="MFS_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23514">
        <property type="entry name" value="BYPASS OF STOP CODON PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23514:SF16">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G17270)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="51"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="113"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="174"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="203"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="263"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="329"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="353"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="387"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="417"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="50"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAF99906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="444" mass="48109" checksum="D44140B9FFF47B28" modified="2016-09-07" version="1">MSTTTVIETGSANPAHIELQPIRTSPRPSIRTVARIQQDGLILDKTNFVRILTIGFSYIFAGLNDGSLGALTPYILRTYRVGTAHVALIYAASFVGWLLAAATNSHLVHHFQLGAILTIGAVLQLAAHLFRFWTPPFGLYVVTFFIQSAGMGYQDSHSNSYVASIQGSHRWLGFIHAMYALGCLIAPFVATALAARIGDRWPLFYLFLVGIGTINIVTVLVSFRDSLKVQDKVSSSEIVEEGAHNHGNSASRDILDTLKSPPVYLISMFYFFMLGVGITAGGWIVEYLVSARNGKLPDVGYVPTGLWGGIFLGRVLLSEPAHRFGERRMGLGCCLMILVFHLIFWLVPNLVSSAVSVSLLGFFYGPLFATGMSIASKIFDKRIQATAMGLIFVLAQAGGALFPSITGVIASQAGVKVMQPILVGLIVAMGISWTLIPKVPKRDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BZR7</accession>
    <name>A0A177BZR7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1155598</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441559">
        <property type="protein sequence ID" value="OAG00656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031021.1">
        <property type="nucleotide sequence ID" value="XM_018176942.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BZR7"/>
    <dbReference type="STRING" id="1460663.A0A177BZR7"/>
    <dbReference type="GeneID" id="28760428"/>
    <dbReference type="InParanoid" id="A0A177BZR7"/>
    <dbReference type="OrthoDB" id="37537at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050791">
        <property type="entry name" value="Aldo-Keto_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43625">
        <property type="entry name" value="AFLATOXIN B1 ALDEHYDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43625:SF7">
        <property type="entry name" value="REDUCTASE (YAKC), PUTATIVE (AFU_ORTHOLOGUE AFUA_8G01560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="2">
        <location>
            <begin position="16"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG00656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="333" mass="36447" checksum="8139E798B1A4A05D" modified="2016-09-07" version="1">MVKTIKFGDIEVPVPGFGAMGLSHGLGNQFTLEQAEPVLLRALELGCTFWDTAVIYGAGINETLLGEFIRKHNARDKIFLASKCGLDIFNKESTGVYGGVTNTPEHIATYIEGTIARLGFSPDLYYLHRIDPTTPLDTSIPALAALRSSGKTKYIGLSECSAATLRRANEIAKIDAVQAEYSAFETLHESDGLVDAARELGVAYVAYSPLGHGWLVDDFDYASPEDFPEGDYRRKVPKFQGDNFYANKKIVEEVKGIARKKGVSTSQVALAWVASQGMIAIPGTTKVHRLEENWGSRDVVLSDEEMGHMREVIEGAKVVGARYWPEMQATVGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C066</accession>
    <name>A0A177C066_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1180832</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441560">
        <property type="protein sequence ID" value="OAF99999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030365.1">
        <property type="nucleotide sequence ID" value="XM_018180510.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C066"/>
    <dbReference type="GeneID" id="28763996"/>
    <dbReference type="InParanoid" id="A0A177C066"/>
    <dbReference type="OrthoDB" id="3943581at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAF99999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="368" mass="39018" checksum="F686C36250A624B5" modified="2016-09-07" version="1">MAPSFPFTFRVGTPNGLSFKPSMPAVAPRSTVGLRDDNFTGNHKLVIVLVVLAVIAGILLVIFSSRKAREQDRLAKERGAFLRGLQRRNNEPSMVAMAIPLRIKIIASSITLIVIIAITLATSLEIRAHEAPRQLIQISKAQLAKDGKLEAQVQAQAQQAGAAINGSAFDRGDILSGTSTVAADITATWVITGRPTIIASDEGMIGATATAQPTSVDEGFIGNTVGTSKPTPSVRPLPPPAPQVPIVAMSYAGDGGPKHCRGQLLQKLNLPRPAKTWLNGTCVDLPGHARCGVFYSAKGDNCEAQLFTMEGCYNTTETYVNTVVFMPEERPVGAMWKSMFIRCGLDVPEPALIDPSILGGALKKPGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C1S9</accession>
    <name>A0A177C1S9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptidase A1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1179952</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441558">
        <property type="protein sequence ID" value="OAG00839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031204.1">
        <property type="nucleotide sequence ID" value="XM_018180449.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C1S9"/>
    <dbReference type="GeneID" id="28763935"/>
    <dbReference type="InParanoid" id="A0A177C1S9"/>
    <dbReference type="OrthoDB" id="5361565at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="454"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="515"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="523"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG00839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="569" mass="60903" checksum="4A84C2FA874C53CB" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C262</accession>
    <name>A0A177C262_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">precorrin-2 dehydrogenase</fullName>
            <ecNumber evidence="2">1.3.1.76</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CC84DRAFT_1199039</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>precorrin-2 + NAD(+) = sirohydrochlorin + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:15613"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58351"/>
            <dbReference type="ChEBI" id="CHEBI:58827"/>
            <dbReference type="EC" id="1.3.1.76"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Porphyrin-containing compound metabolism; siroheme biosynthesis; sirohydrochlorin from precorrin-2: step 1/1.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.76" evidence="2"/>
    <dbReference type="EMBL" id="KV441558">
        <property type="protein sequence ID" value="OAG00942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031307.1">
        <property type="nucleotide sequence ID" value="XM_018181596.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C262"/>
    <dbReference type="FunCoup" id="A0A177C262">
        <property type="interactions" value="120"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177C262"/>
    <dbReference type="GeneID" id="28765082"/>
    <dbReference type="InParanoid" id="A0A177C262"/>
    <dbReference type="OrthoDB" id="1721126at2759"/>
    <dbReference type="UniPathway" id="UPA00262">
        <property type="reaction ID" value="UER00222"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004325">
        <property type="term" value="F:ferrochelatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043115">
        <property type="term" value="F:precorrin-2 dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019354">
        <property type="term" value="P:siroheme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.110">
        <property type="entry name" value="Siroheme synthase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3280.10">
        <property type="entry name" value="Siroheme synthase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028161">
        <property type="entry name" value="Met8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028162">
        <property type="entry name" value="Met8_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028281">
        <property type="entry name" value="Sirohaem_synthase_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006367">
        <property type="entry name" value="Sirohaem_synthase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01470">
        <property type="entry name" value="cysG_Nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35330">
        <property type="entry name" value="SIROHEME BIOSYNTHESIS PROTEIN MET8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35330:SF1">
        <property type="entry name" value="SIROHEME BIOSYNTHESIS PROTEIN MET8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13241">
        <property type="entry name" value="NAD_binding_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14823">
        <property type="entry name" value="Sirohm_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14824">
        <property type="entry name" value="Sirohm_synth_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75615">
        <property type="entry name" value="Siroheme synthase middle domains-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Siroheme synthase central" evidence="8">
        <location>
            <begin position="131"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="Siroheme biosynthesis protein Met8 C-terminal" evidence="7">
        <location>
            <begin position="160"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF14824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAG00942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="247" mass="27385" checksum="65077E77303A38DC" modified="2016-09-07" version="1">MKSDFPEIQGGGSLILAWQIRNKRVLVIGGGEVAAGRIVKVLNADAKCVVVAPRSGLNDEVAYRVDQKQVEHVDRNFEPSDLDGADMVMCAIDDPEASTQVWKLCKEKRIAANIADVPPECDFYFGSEHRDGPLQIMVSTNGNGPRLANFVRRRIAATLPYNIGTAIQRVGMLRKKLRKVAPNIEEGPKRMAWMIKVSDKWTLEDLCEMTDEDMDGLLGFYKPNTVPSLDEVRLAQPDGAFDGPFLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C2F1</accession>
    <name>A0A177C2F1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1228343</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441557">
        <property type="protein sequence ID" value="OAG01331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031696.1">
        <property type="nucleotide sequence ID" value="XM_018183634.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C2F1"/>
    <dbReference type="GeneID" id="28767120"/>
    <dbReference type="InParanoid" id="A0A177C2F1"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG01331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="124" mass="13839" checksum="323558A7F7CDA25F" modified="2016-09-07" version="1">MYRPGDIVLMLQTCALVYQKYQIQGASSGGPFTLAVAAIAPKREVLATRIIAGAVPIEAGRRCRNFRRLLGKYLLLAFPWCSKLQARSQLQPEVRNIRSGQIAIFDEENETTGSVECYRALNSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2023-06-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C2K6</accession>
    <name>A0A177C2K6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_210951</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441557">
        <property type="protein sequence ID" value="OAG01675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032040.1">
        <property type="nucleotide sequence ID" value="XM_018185594.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C2K6"/>
    <dbReference type="GeneID" id="28769080"/>
    <dbReference type="InParanoid" id="A0A177C2K6"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG01675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="112" mass="12020" checksum="582CD4947F39CA57" modified="2016-09-07" version="1">MRGVRSYGVLGGVRNEPWRCSSLVGMAPVALSRNAALRSPSRRWPHEQAMVNSCTCAPFTLLSLTPIVFALQDCRNNAAPQLTVPLARAQAMFPGAPPTHPLSSALPWVAPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C2X0</accession>
    <name>A0A177C2X0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1154594</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441558">
        <property type="protein sequence ID" value="OAG01107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031472.1">
        <property type="nucleotide sequence ID" value="XM_018176898.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C2X0"/>
    <dbReference type="STRING" id="1460663.A0A177C2X0"/>
    <dbReference type="GeneID" id="28760384"/>
    <dbReference type="InParanoid" id="A0A177C2X0"/>
    <dbReference type="OrthoDB" id="4605274at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053228">
        <property type="entry name" value="Stereospecific_Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37574">
        <property type="entry name" value="LIPASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37574:SF1">
        <property type="entry name" value="LIPASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008057673" evidence="2">
        <location>
            <begin position="18"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG01107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="462" mass="49255" checksum="F6987E11393BA6C7" modified="2016-09-07" version="1">MHFSYLLIAALFSPINALPASSSYSAPAPVSRAPGLLGLTDGLGKVVDGLLDRIHDETEELTTAVLALLQQLDEVVPTATPTSIEDVATILKGIAGAEPTTFIESVVSLAKNGLGPGSFEGVFKQYSAGSNSENNVNEREPSKKLYPSAGDNDAPYSIDEETLRAAIYIPDTFTYGEKPPVILVPGTATKGGLCYEANLAKLLTKEDYADPLWLNIPGWLLESAPWNSEFVAYAINYIADITSQNVSVIALSQGNLDTQWALTYWPSTRNVVSDYIAVSPDYHGSILLDFLCPKLTEGIVGCAPAVIQQKYNAKFIEHFRSVGGASAWVPTTTVYTGTDDVVQPQHGTNASALLGDDRDVGVLNVELQLHCPLLSPALVGTHESLLWGQPLQVLIKDALTHDGPASIERISDWNDACSMLAAEGLGVADVVGTTAAVPVAFAAMFLYDKKVLYEPALPAYAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C3C4</accession>
    <name>A0A177C3C4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Kelch repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_1252906</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441556">
        <property type="protein sequence ID" value="OAG02244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032609.1">
        <property type="nucleotide sequence ID" value="XM_018184372.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C3C4"/>
    <dbReference type="STRING" id="1460663.A0A177C3C4"/>
    <dbReference type="GeneID" id="28767858"/>
    <dbReference type="InParanoid" id="A0A177C3C4"/>
    <dbReference type="OrthoDB" id="45365at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46344:SF27">
        <property type="entry name" value="KELCH REPEAT SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46344">
        <property type="entry name" value="OS02G0202900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01344">
        <property type="entry name" value="Kelch_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00612">
        <property type="entry name" value="Kelch"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008057653" evidence="3">
        <location>
            <begin position="18"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAG02244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="329" mass="35072" checksum="9C395DA32F591BBA" modified="2016-09-07" version="1">MRSLALIFSTFASLVLSETWHRLPDVPISPRQEHATVLLPPGDIVLVGGVTNGTQSTTSLVQSYSITRRKWTSLPPLPVPLNHPNAAVLSGQLYVFGGLAQKNTSWTAIPNSYRYDAKTRSWRRIADVPDGGVGSAAVGVWDGKVILAGGLKEIQLVSPYTQSTISSVYIYDSLTNAYLALPAAAAQLPDTRDHACGAVIEHRFYVLGGRERGQLTGKSSVPVLDLNDLNKGWSVAEGIMPSPRAGLACGIVGKKVYTFGGEGNLKVESGVWNSTEVYDVAQDSWNTLVGMKVPRHGGGAVAFNGKIYVPGGGDVIGISPTSYFDVFVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C4A0</accession>
    <name>A0A177C4A0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">FAD/NAD(P)-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CC84DRAFT_1100521</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NADH dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441557">
        <property type="protein sequence ID" value="OAG01500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031865.1">
        <property type="nucleotide sequence ID" value="XM_018174870.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C4A0"/>
    <dbReference type="STRING" id="1460663.A0A177C4A0"/>
    <dbReference type="GeneID" id="28758356"/>
    <dbReference type="InParanoid" id="A0A177C4A0"/>
    <dbReference type="OrthoDB" id="3244603at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003954">
        <property type="term" value="F:NADH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045024">
        <property type="entry name" value="NDH-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43706">
        <property type="entry name" value="NADH DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43706:SF17">
        <property type="entry name" value="NADH DEHYDROGENASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="6">
        <location>
            <begin position="6"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAG01500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="426" mass="47663" checksum="14BD54E5D153392D" modified="2016-09-07" version="1">MASKPTIAIIGSGWGGFTISHALSLAKYNVTVISPSRTIQYTPLLASAAAGMFNFRLAEEPVRRRNKLPGLSYYNARVEDIDFSSRTLQCKATHSDMTEEHLKDVDSFKLKYDKLVIAPGCDVQTFGTPGALEHAIFLRTTDDARKIQKRILDMVDAASIPGLTDTQQRDMLRILIVGGGAIGIEATAELFDLWDHELRHVYPHLDGKVTMEIHDVAPALLGTFDKRLGEYAARKLEGRGVQIKTSSHIEKVDAGAIWTKEIGELRYGMLIWATGNGTNPLVEKLDVKKDGKLQRIVTDKRLRVFDTNDQLIEDVYALGDSADIEGYTLPTLAEVALQKAQYLAKELNEAEEPAKAFEYNQRANIAYLGQHDGVIGGKEQWTGQSAWLAWRSGSIYHWPRSWRRTIMIGVSWFFNKIGGRDIARKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C4B2</accession>
    <name>A0A177C4B2_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Integral membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CC84DRAFT_1124352</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG02584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032949.1">
        <property type="nucleotide sequence ID" value="XM_018175688.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C4B2"/>
    <dbReference type="FunCoup" id="A0A177C4B2">
        <property type="interactions" value="17"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177C4B2"/>
    <dbReference type="GeneID" id="28759174"/>
    <dbReference type="InParanoid" id="A0A177C4B2"/>
    <dbReference type="OrthoDB" id="4005299at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018825">
        <property type="entry name" value="DUF2427"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018827">
        <property type="entry name" value="YTP1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31685:SF3">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_6G12730)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31685">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_6G12730)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10348">
        <property type="entry name" value="DUF2427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10355">
        <property type="entry name" value="Ytp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008057728" description="Integral membrane protein" evidence="3">
        <location>
            <begin position="25"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="93"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="285"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="323"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="365"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="398"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="450"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="487"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="516"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="554"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2427" evidence="4">
        <location>
            <begin position="59"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="Protein YTP1-like C-terminal" evidence="5">
        <location>
            <begin position="289"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF10355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAG02584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="596" mass="65852" checksum="4C666BF03D5CB9F1" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C4C7</accession>
    <name>A0A177C4C7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">AA9 family lytic polysaccharide monooxygenase</fullName>
            <ecNumber evidence="5">1.14.99.56</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Endo-beta-1,4-glucanase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Glycosyl hydrolase 61 family protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_1198464</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Lytic polysaccharide monooxygenase (LMPO) that depolymerizes crystalline and amorphous polysaccharides via the oxidation of scissile alpha- or beta-(1-4)-glycosidic bonds, yielding C1 and/or C4 oxidation products. Catalysis by LPMOs requires the reduction of the active-site copper from Cu(II) to Cu(I) by a reducing agent and H(2)O(2) or O(2) as a cosubstrate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>[(1-&gt;4)-beta-D-glucosyl]n+m + reduced acceptor + O2 = 4-dehydro-beta-D-glucosyl-[(1-&gt;4)-beta-D-glucosyl]n-1 + [(1-&gt;4)-beta-D-glucosyl]m + acceptor + H2O.</text>
            <dbReference type="EC" id="1.14.99.56"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 5">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="5">Has a modular structure: an endo-beta-1,4-glucanase catalytic module at the N-terminus, a linker rich in serines and threonines, and a C-terminal carbohydrate-binding module (CBM).</text>
    </comment>
    <dbReference type="EC" id="1.14.99.56" evidence="5"/>
    <dbReference type="EMBL" id="KV441556">
        <property type="protein sequence ID" value="OAG02266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032631.1">
        <property type="nucleotide sequence ID" value="XM_018181567.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C4C7"/>
    <dbReference type="STRING" id="1460663.A0A177C4C7"/>
    <dbReference type="GeneID" id="28765053"/>
    <dbReference type="InParanoid" id="A0A177C4C7"/>
    <dbReference type="OrthoDB" id="3496539at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008810">
        <property type="term" value="F:cellulase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030248">
        <property type="term" value="F:cellulose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd21175">
        <property type="entry name" value="LPMO_AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049892">
        <property type="entry name" value="AA9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005103">
        <property type="entry name" value="AA9_LPMO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353:SF2">
        <property type="entry name" value="ENDO-BETA-1,4-GLUCANASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03443">
        <property type="entry name" value="AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="4 5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Auxiliary Activity family 9 catalytic" evidence="7">
        <location>
            <begin position="20"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="243"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU368122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAG02266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="291" mass="31028" checksum="18AD73E3C586205F" modified="2016-09-07" version="1">MKVSTSVLAGVAFANSAAAHYFFDKLVIDGKETNSMQYVRENTRPEKYNPTKWKNTRDDMTPDLTDFRCNKGAFESASRTETAEVQAGATLAMKLAVGATMQHPGPQLVYMSKAPSTAQSYEGDGDWFKIMESGVCDPSKDFTKDAWCSWDKDRIEFTIPKDTPDGEYLIRPEHIALHGAHDGQAEFYYGCAQVKVTGGGSGAPSETAKIPGVYKVNDPEVNFSLWGGYKEYTIPGPALWTGGGSSGGSSAGNTTEQNELPSTPSAVATPAASVAPSASAQAGAGRISLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C4D1</accession>
    <name>A0A177C4D1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF1770-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1221023</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441557">
        <property type="protein sequence ID" value="OAG01530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031895.1">
        <property type="nucleotide sequence ID" value="XM_018183221.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C4D1"/>
    <dbReference type="STRING" id="1460663.A0A177C4D1"/>
    <dbReference type="GeneID" id="28766707"/>
    <dbReference type="InParanoid" id="A0A177C4D1"/>
    <dbReference type="OrthoDB" id="2430343at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140580">
        <property type="term" value="F:mitochondrion autophagosome adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000423">
        <property type="term" value="P:mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013898">
        <property type="entry name" value="Atg43"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38699">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38699:SF1">
        <property type="entry name" value="MITOPHAGY RECEPTOR ATG43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08589">
        <property type="entry name" value="ATG43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG01530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="175" mass="19890" checksum="122C325C9951F280" modified="2016-09-07" version="1">MDNPGTSEIASLLQNTHIKRHPSPRHDLNPSTAASAKQPVRLDVHPDPDASDVDEDEVPLGVLRPIPRRNAMPPLPDLRLEQTYLKSIEHAESWQAVAWITFKDHVLLCFGQGLVWTLVLSGWRHLNRSAKFSGRGVGARIRRWWWGVNNWKIPNEKLTDTKLAKNASGYYKNSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C538</accession>
    <name>A0A177C538_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_1261545</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG02864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033229.1">
        <property type="nucleotide sequence ID" value="XM_018185074.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C538"/>
    <dbReference type="STRING" id="1460663.A0A177C538"/>
    <dbReference type="GeneID" id="28768560"/>
    <dbReference type="InParanoid" id="A0A177C538"/>
    <dbReference type="OrthoDB" id="2735536at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050425">
        <property type="entry name" value="NAD(P)_dehydrat-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366">
        <property type="entry name" value="NAD DEPENDENT EPIMERASE/DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366:SF564">
        <property type="entry name" value="STEROL-4-ALPHA-CARBOXYLATE 3-DEHYDROGENASE, DECARBOXYLATING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="3">
        <location>
            <begin position="7"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAG02864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="358" mass="39647" checksum="E5ECF7C33C0E2C12" modified="2016-09-07" version="1">MVQEETVLLTGATGNVGGVILEHLFQTTNYNVNIVLRNAPKQIPLFRARYASEASTGRLTFTSIPDMTTPGAFDAAAAYASAIIHCATPVGSDTDWVKDMIEPTWTIDHSILTAAQKSLTIKRVIICGTLLQTLGPYNLFDPATTITDTSYNSTTFEEAKAGPWRNAYMFSKTNAERKTWAWYEDQGGQEGTGFDIVMLLPPMITGRSPQVGFQPGPGPGGIGRVYHALFESKTAEDMDAMFPIFLDTDDVARAHVLALEREKVPGNQRYLLASPEMVDLRSVVARMRKEYAEVRHRLPDVGIDEEGSKGRKAKLVKVDTSKSEVVFGRDWESAYNSIKETVLDVVRWEQETESARVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C5C2</accession>
    <name>A0A177C5C2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1099478</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441556">
        <property type="protein sequence ID" value="OAG01917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032282.1">
        <property type="nucleotide sequence ID" value="XM_018174826.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C5C2"/>
    <dbReference type="STRING" id="1460663.A0A177C5C2"/>
    <dbReference type="GeneID" id="28758312"/>
    <dbReference type="InParanoid" id="A0A177C5C2"/>
    <dbReference type="OrthoDB" id="5587021at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012814028" evidence="2">
        <location>
            <begin position="16"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="246"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="20"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="254"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="270"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG01917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="279" mass="28753" checksum="949FB1B84160C6A8" modified="2016-09-07" version="1">MLVLFFLSFATQLLAQSATSSATQPPTSSSSRAPITNGTSTTPPDVATTSTVPDVYLNVPELHVGRIELDVEKLQADINLNAKVAGLVTVNAGVQVSVEKINITIADVDVQLELVVRLGHLVDIVERVFESLDLNPLLLGLINNVTNLVGDVIGAVDGLLGSITNGGKTLNFLVDNLGNIVQEVVGGATGALSQIVGNYQQNMTQVGDIKQLGNGLIQKTFSYDPLSALVDIVFNAAGQVVQATVQKGSGGGSSSTTASATATPMPVTLPVSTDASTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C5U9</accession>
    <name>A0A177C5U9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">HSP70-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CC84DRAFT_1099254</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441556">
        <property type="protein sequence ID" value="OAG02148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032513.1">
        <property type="nucleotide sequence ID" value="XM_018174813.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C5U9"/>
    <dbReference type="STRING" id="1460663.A0A177C5U9"/>
    <dbReference type="GeneID" id="28758299"/>
    <dbReference type="InParanoid" id="A0A177C5U9"/>
    <dbReference type="OrthoDB" id="3782449at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="HEAT SHOCK PROTEIN 70KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008057792" evidence="4">
        <location>
            <begin position="32"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAG02148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="515" mass="56435" checksum="6D67F6F413897D99" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C625</accession>
    <name>A0A177C625_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Linalool dehydratase/isomerase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1252845</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441556">
        <property type="protein sequence ID" value="OAG02228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032593.1">
        <property type="nucleotide sequence ID" value="XM_018184370.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C625"/>
    <dbReference type="STRING" id="1460663.A0A177C625"/>
    <dbReference type="GeneID" id="28767856"/>
    <dbReference type="InParanoid" id="A0A177C625"/>
    <dbReference type="OrthoDB" id="9979195at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041411">
        <property type="entry name" value="Ldi"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18566">
        <property type="entry name" value="Ldi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="Linalool dehydratase/isomerase" evidence="2">
        <location>
            <begin position="251"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG02228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="672" mass="74044" checksum="F25BB9DECB0F0A54" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C6A6</accession>
    <name>A0A177C6A6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1179199</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441556">
        <property type="protein sequence ID" value="OAG02267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032632.1">
        <property type="nucleotide sequence ID" value="XM_018180395.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C6A6"/>
    <dbReference type="GeneID" id="28763881"/>
    <dbReference type="InParanoid" id="A0A177C6A6"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG02267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="173" mass="19212" checksum="C87647D1405693DC" modified="2016-09-07" version="1">MSDSSPPMREWTLSDVTDPLLRTRTEAFKVLFSGLTIRKVHDVLLNSPVRDWNAIHSNLQQEASKSGPSATLSNEDNRPQNSQHGSTSEESATDDGTPVDWKGQKITPRDLACRMNGVKLSIKSMRTGVDNLKKSITEQLDDLVEILELTMGEAHGIQNSLHILQNYENEAGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C6Z5</accession>
    <name>A0A177C6Z5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CC84DRAFT_1188732</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG02548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032913.1">
        <property type="nucleotide sequence ID" value="XM_018181004.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C6Z5"/>
    <dbReference type="STRING" id="1460663.A0A177C6Z5"/>
    <dbReference type="GeneID" id="28764490"/>
    <dbReference type="InParanoid" id="A0A177C6Z5"/>
    <dbReference type="OrthoDB" id="5296287at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF68">
        <property type="entry name" value="MULTIDRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01120)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="112"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="153"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="205"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="240"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="269"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="344"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="383"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="422"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="447"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="480"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="514"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="114"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="30"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="31"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="50"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAG02548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="549" mass="60193" checksum="76F0C5C34AB758B1" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C735</accession>
    <name>A0A177C735_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">1-phosphatidylinositol-4-phosphate 5-kinase</fullName>
            <ecNumber evidence="2">2.7.1.68</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">1-phosphatidylinositol 4-phosphate kinase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Diphosphoinositide kinase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">PIP5K</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CC84DRAFT_897649</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14425"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58178"/>
            <dbReference type="ChEBI" id="CHEBI:58456"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.68"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.1.68" evidence="2"/>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG02557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032922.1">
        <property type="nucleotide sequence ID" value="XM_018187830.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C735"/>
    <dbReference type="STRING" id="1460663.A0A177C735"/>
    <dbReference type="GeneID" id="28771316"/>
    <dbReference type="InParanoid" id="A0A177C735"/>
    <dbReference type="OrthoDB" id="20783at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016308">
        <property type="term" value="F:1-phosphatidylinositol-4-phosphate 5-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17303">
        <property type="entry name" value="PIPKc_PIP5K_yeast_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.800.10:FF:000009">
        <property type="entry name" value="Phosphatidylinositol 4-phosphate 5-kinase its3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.810.10">
        <property type="entry name" value="2-Layer Sandwich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.800.10">
        <property type="entry name" value="Phosphatidylinositol Phosphate Kinase II Beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027483">
        <property type="entry name" value="PInositol-4-P-4/5-kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002498">
        <property type="entry name" value="PInositol-4-P-4/5-kinase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027484">
        <property type="entry name" value="PInositol-4-P-5-kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023610">
        <property type="entry name" value="PInositol-4/5-P-5/4-kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23086:SF8">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 5-PHOSPHATE 4-KINASE, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23086">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-4-PHOSPHATE 5-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01504">
        <property type="entry name" value="PIP5K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00330">
        <property type="entry name" value="PIPKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56104">
        <property type="entry name" value="SAICAR synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51455">
        <property type="entry name" value="PIPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PIPK" evidence="13">
        <location>
            <begin position="306"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="47"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="145"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="222"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="723"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="12"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="61"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="107"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="723"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="746"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="808"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="829"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="888"/>
            <end position="904"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00078403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00080374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00082306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OAG02557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="916" mass="103070" checksum="AA991E1662B4BF40" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C7R9</accession>
    <name>A0A177C7R9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_1061912</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG03693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034058.1">
        <property type="nucleotide sequence ID" value="XM_018173594.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C7R9"/>
    <dbReference type="STRING" id="1460663.A0A177C7R9"/>
    <dbReference type="GeneID" id="28757080"/>
    <dbReference type="InParanoid" id="A0A177C7R9"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF68">
        <property type="entry name" value="MULTIDRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01120)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="25"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="95"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="119"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="149"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="182"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="257"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="294"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="327"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="27"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAG03693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="442" mass="48469" checksum="4D3C6F0099E4FFD3" modified="2016-09-07" version="1" fragment="single">NGNRVGWDAEDDPENPKNWSFWTKWLQICLLIVPVFTSSFGFTVMAGPAAEIMGTLRVHNSQLVTFAITAYTLGQFFGQLIILPLHRKYGIRNVLLLHLVLFPTANICCALSQNAGMLISFRFLSGLTSTFSFLLGYEASIEMFDAYAMGLGGGILAISATIGTTVGLVSGSFLVARLGWQWAFWITAITSGGFGLPSVFLLRETSKKVLLTRKAIRLRKETFNQALYAEVATEKLTRLYQGVWDTYSQHLSKPSLVILYIHSATFQGSIHLIYTTLGYVFLQQYSLAGSHISVAATGIAVSITISAFLLSPFTASSSAWTIQTRALYAKVIGSLMMATLCEVSGFITYGWTAEYHIDKILPILSLSLIPLGGQVSVSCPSPYFRCTIFVVDLVSKEPTRYIAHDTIRLLFCAVLPLGGIPLYRSIGVGWGNTLLGLLNLFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C8K5</accession>
    <name>A0A177C8K5_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Coatomer subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CC84DRAFT_1122699</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 10">Golgi apparatus membrane</location>
            <topology evidence="1 10">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG03461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033826.1">
        <property type="nucleotide sequence ID" value="XM_018175638.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C8K5"/>
    <dbReference type="FunCoup" id="A0A177C8K5">
        <property type="interactions" value="1229"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177C8K5"/>
    <dbReference type="GeneID" id="28759124"/>
    <dbReference type="InParanoid" id="A0A177C8K5"/>
    <dbReference type="OrthoDB" id="10261470at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008298">
        <property type="term" value="P:intracellular mRNA localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd22948">
        <property type="entry name" value="Coatomer_WDAD_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.470:FF:000002">
        <property type="entry name" value="Coatomer subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000022">
        <property type="entry name" value="Coatomer subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006692">
        <property type="entry name" value="Beta-prop_COPA/B_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047312">
        <property type="entry name" value="Coatomer_alpha_WD-assoc_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016391">
        <property type="entry name" value="Coatomer_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010714">
        <property type="entry name" value="Coatomer_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050844">
        <property type="entry name" value="Coatomer_complex_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011044">
        <property type="entry name" value="Quino_amine_DH_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056176">
        <property type="entry name" value="TPR_COPA_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19876">
        <property type="entry name" value="COATOMER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19876:SF1">
        <property type="entry name" value="COATOMER SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04053">
        <property type="entry name" value="B-prop_COPA_B_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06957">
        <property type="entry name" value="COPI_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23953">
        <property type="entry name" value="TPR_COPA_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003354">
        <property type="entry name" value="Coatomer_alpha_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50969">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 10" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8 10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 10" id="KW-0813">Transport</keyword>
    <keyword evidence="4 11" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="53"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="95"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="137"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="211"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="255"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="COPA/B second beta-propeller" evidence="12">
        <location>
            <begin position="349"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="domain" description="COPA/B TPR" evidence="14">
        <location>
            <begin position="622"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="domain" description="Coatomer alpha subunit C-terminal" evidence="13">
        <location>
            <begin position="843"/>
            <end position="1219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR003354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF04053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF06957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF23953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OAG03461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="1221" mass="136102" checksum="4C5FED50C369F880" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C8Q7</accession>
    <name>A0A177C8Q7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FAD/NAD(P)-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1251266</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG03158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033523.1">
        <property type="nucleotide sequence ID" value="XM_018184325.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C8Q7"/>
    <dbReference type="FunCoup" id="A0A177C8Q7">
        <property type="interactions" value="393"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177C8Q7"/>
    <dbReference type="GeneID" id="28767811"/>
    <dbReference type="InParanoid" id="A0A177C8Q7"/>
    <dbReference type="OrthoDB" id="202203at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004174">
        <property type="term" value="F:electron-transferring-flavoprotein dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43735">
        <property type="entry name" value="APOPTOSIS-INDUCING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43735:SF11">
        <property type="entry name" value="HYPOTHETICAL OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="1">
        <location>
            <begin position="2"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG03158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="373" mass="40713" checksum="A127546744CC3E92" modified="2016-09-07" version="1" fragment="single">LGTNVAEQLAKAAQGRFRVLLVERNSHFQHLFAFPRYAVTTKVPTNKAFIPYQASRLGENGSFIQASAIGLTSSAVQLDRKVLLDGQQVDSIPYFALAIATGTKLAPPSNVPGENKLSRTTYLRKHAEQVERSEQIVIIGAGAVGVQMALDAKELYPEKSITLVHSRENVMNKFHPDLHSVVKARADELGVNLVLGKRVKLPKEGYPVDNGRFDVELVDGTKIPTDLAITCNGMTPQSEIIRSLSPDVIDEQGYIAVKDTLQIQDDRFPNVFSLGDIAATAAHKAARPAMKQAEIVTKNVVHLFGQEPLEKYEVTDPAAIHLTLGIKKSVIFRNPSPASDDRPVVMHKDDGSLDMGIDGVWARRGADISNPNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C8R2</accession>
    <name>A0A177C8R2_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1220006</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG03100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033465.1">
        <property type="nucleotide sequence ID" value="XM_018183127.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C8R2"/>
    <dbReference type="GeneID" id="28766613"/>
    <dbReference type="InParanoid" id="A0A177C8R2"/>
    <dbReference type="OrthoDB" id="3712704at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF10">
        <property type="entry name" value="TOL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG03100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="314" mass="35797" checksum="7E98E6875E60E662" modified="2016-09-07" version="1">MDPPVKITFQLEDFPTTPTGTGDGLCQECYDSFKPVGPARRKVPRISSLRVSSKSCQGCQTLLDFFTAAQRQSVYPVSASNPVDLKRSWAYWVSEYSQKKHTNESQAIALSGLITFVQDLKKDEPLLGLWKQELAEGLLWERGIWHEPAPRKRIAPFPSWTWMSLPGAVQYPSFRLTSKHIELIHPRICWSQGEYDSSLEIAELLLRAKVLKGTLTYHGRESAQSSLYVEIGSSKVPLFERVDIPDSYYDNTTVQLILIGGTDRHWFFLIASNVVNPERNPYVRIGRAYSPCDRAFKKLEEHFKTVNSQVLNLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C982</accession>
    <name>A0A177C982_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1151733</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG03280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033645.1">
        <property type="nucleotide sequence ID" value="XM_018176764.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C982"/>
    <dbReference type="GeneID" id="28760250"/>
    <dbReference type="InParanoid" id="A0A177C982"/>
    <dbReference type="OrthoDB" id="3525430at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="440"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="477"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="511"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="542"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="588"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="693"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="728"/>
            <end position="746"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG03280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="747" mass="84322" checksum="F5CBB2E3E0EDE510" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C9Q0</accession>
    <name>A0A177C9Q0_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">alpha-glucosidase</fullName>
            <ecNumber evidence="5">3.2.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Glucosidase II subunit alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CC84DRAFT_1120912</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing (1-&gt;4)-linked alpha-D-glucose residues with release of alpha-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.20"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Glycan metabolism; N-glycan metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the glycosyl hydrolase 31 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.20" evidence="5"/>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG04474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034839.1">
        <property type="nucleotide sequence ID" value="XM_018175595.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C9Q0"/>
    <dbReference type="FunCoup" id="A0A177C9Q0">
        <property type="interactions" value="948"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177C9Q0"/>
    <dbReference type="GeneID" id="28759081"/>
    <dbReference type="InParanoid" id="A0A177C9Q0"/>
    <dbReference type="OrthoDB" id="3237269at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017177">
        <property type="term" value="C:glucosidase II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004558">
        <property type="term" value="F:alpha-1,4-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106407">
        <property type="term" value="F:Glc2Man9GlcNAc2 oligosaccharide glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033919">
        <property type="term" value="F:glucan 1,3-alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070880">
        <property type="term" value="P:fungal-type cell wall beta-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006491">
        <property type="term" value="P:N-glycan processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd06603">
        <property type="entry name" value="GH31_GANC_GANAB_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14752">
        <property type="entry name" value="GH31_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1760">
        <property type="entry name" value="glycosyl hydrolase (family 31)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033403">
        <property type="entry name" value="DUF5110"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030458">
        <property type="entry name" value="Glyco_hydro_31_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048395">
        <property type="entry name" value="Glyco_hydro_31_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025887">
        <property type="entry name" value="Glyco_hydro_31_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000322">
        <property type="entry name" value="Glyco_hydro_31_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762">
        <property type="entry name" value="ALPHA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762:SF54">
        <property type="entry name" value="BCDNA.GH04962"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17137">
        <property type="entry name" value="DUF5110"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13802">
        <property type="entry name" value="Gal_mutarotas_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01055">
        <property type="entry name" value="Glyco_hydro_31_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21365">
        <property type="entry name" value="Glyco_hydro_31_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00129">
        <property type="entry name" value="GLYCOSYL_HYDROL_F31_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008057905" description="alpha-glucosidase" evidence="14">
        <location>
            <begin position="32"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 31 N-terminal" evidence="16">
        <location>
            <begin position="98"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 31 TIM barrel" evidence="15">
        <location>
            <begin position="404"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 31 C-terminal" evidence="18">
        <location>
            <begin position="741"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="domain" description="DUF5110" evidence="17">
        <location>
            <begin position="848"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="208"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="208"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00042895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF01055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF13802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF17137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF21365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="OAG04474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="987" mass="111596" checksum="76C79B9FBC255F66" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2023-06-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C9S9</accession>
    <name>A0A177C9S9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1165818</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG03602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033967.1">
        <property type="nucleotide sequence ID" value="XM_018178802.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C9S9"/>
    <dbReference type="GeneID" id="28762288"/>
    <dbReference type="InParanoid" id="A0A177C9S9"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG03602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="414" mass="45095" checksum="6AD4759E8F26B520" modified="2016-09-07" version="1">MVMWTCRSDYEWGYSVARAIRPACFAFGSTRDWASGRSLFLLALPGTVHFLLGRKYKGWGGLPVFAWSRSHPLPLFLLLWTESLACCRMADTRFRRRRVPYARSSRAGRSVKKQPGQLARRVGEGKSNIIIMYSYPEVMPVWLAGDLPDNPKSDTNASAFCHFFVPVTQAIPPAGRPGKGPRDSRRKGRKVHVKGLAVTFSVQTWVDLAVSAVFYPVRAGKGFVQEVEGNLRPDGSVGDPKAWCLSKDNYGDYARLRTLEETGLLDANGPFCVASDPSGLPVLQSTTGTMKNAQLRSGLGEAMGKVEWRVGADSKVVGRTLSADVAGPNGIHLPAGGGDGFAQVQQGSVVDFRVYVDINKDAEYSTETGNELAFQPDWQMCFMVKCRGALPGPSGNGGVVGAVVKRVVSTVYYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2023-06-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CB07</accession>
    <name>A0A177CB07_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_790466</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG04361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034726.1">
        <property type="nucleotide sequence ID" value="XM_018187394.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CB07"/>
    <dbReference type="GeneID" id="28770880"/>
    <dbReference type="InParanoid" id="A0A177CB07"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG04361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="94" mass="10595" checksum="205F8368DEC0739B" modified="2016-09-07" version="1">MHLITIKPCLSQDWTHCKWNEPRPCDGSASLLRHHVLGLKFLVVRTEGCVQNLASASHGFSVWKSSQDVPVNWWYGSWGRGGAQHHHYATLSST</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CB84</accession>
    <name>A0A177CB84_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">60S ribosomal protein L14</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_1206478</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the eukaryotic ribosomal protein eL14 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG04934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035299.1">
        <property type="nucleotide sequence ID" value="XM_018182033.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CB84"/>
    <dbReference type="FunCoup" id="A0A177CB84">
        <property type="interactions" value="1056"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CB84"/>
    <dbReference type="GeneID" id="28765519"/>
    <dbReference type="InParanoid" id="A0A177CB84"/>
    <dbReference type="OrthoDB" id="1875589at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030684">
        <property type="term" value="C:preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23702">
        <property type="entry name" value="eL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000030">
        <property type="entry name" value="60S ribosomal protein L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039660">
        <property type="entry name" value="Ribosomal_eL14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002784">
        <property type="entry name" value="Ribosomal_eL14_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11127">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11127:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01929">
        <property type="entry name" value="Ribosomal_L14e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 8" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein eL14" evidence="7">
        <location>
            <begin position="55"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAG04934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="144" mass="16230" checksum="856296E097184EDB" modified="2016-09-07" version="1">MGDADITTSQWRLVEVGRVVVFSGGQYDGRLATVVEIIDHKRVLVDGPSKDAPVPRHAVALAKVSLTPIVIPKLPRGTGRGHVAQQWEKEGVDAKWAESSWSKKRAQFQKRRQLTDFERFKVMKLRKQARFEVRKSLAKVRSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CBH3</accession>
    <name>A0A177CBH3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CC84DRAFT_1247476</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. NIM1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG04965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035330.1">
        <property type="nucleotide sequence ID" value="XM_018184235.1"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CBH3"/>
    <dbReference type="GeneID" id="28767721"/>
    <dbReference type="InParanoid" id="A0A177CBH3"/>
    <dbReference type="OrthoDB" id="504170at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000571">
        <property type="entry name" value="Maternal embryonic leucine zipper kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.220">
        <property type="entry name" value="Fungal kinase associated-1 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031850">
        <property type="entry name" value="Fungal_KA1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043024">
        <property type="entry name" value="KA1_sf_fungal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF110">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16797">
        <property type="entry name" value="Fungal_KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="120"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="91"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="494"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="580"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="767"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="948"/>
            <end position="1092"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="100"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="504"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="600"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="627"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="640"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="677"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="696"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="771"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="797"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="954"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1027"/>
            <end position="1036"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1056"/>
            <end position="1065"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OAG04965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="1294" mass="145516" checksum="5A30907FEEE09516" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CBH5</accession>
    <name>A0A177CBH5_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Phytase A</fullName>
            <ecNumber evidence="4">3.1.3.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Histidine acid phosphatase phyA</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Myo-inositol hexakisphosphate phosphohydrolase A</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Myo-inositol-hexaphosphate 3-phosphohydrolase A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">CC84DRAFT_884491</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>1D-myo-inositol 1,2,4,5,6-pentakisphosphate + H2O = 1D-myo-inositol 1,2,5,6-tetrakisphosphate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:77115"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57798"/>
            <dbReference type="ChEBI" id="CHEBI:195535"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:77116"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>1D-myo-inositol 1,2,5,6-tetrakisphosphate + H2O = 1D-myo-inositol 1,2,6-trisphosphate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:77119"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:195535"/>
            <dbReference type="ChEBI" id="CHEBI:195537"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:77120"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>1D-myo-inositol 1,2,6-trisphosphate + H2O = 1D-myo-inositol 1,2-bisphosphate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:77131"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:195537"/>
            <dbReference type="ChEBI" id="CHEBI:195539"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:77132"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>1D-myo-inositol 1,2-bisphosphate + H2O = 1D-myo-inositol 2-phosphate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:77135"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:84142"/>
            <dbReference type="ChEBI" id="CHEBI:195539"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:77136"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>1D-myo-inositol hexakisphosphate + H2O = 1D-myo-inositol 1,2,4,5,6-pentakisphosphate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:16989"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57798"/>
            <dbReference type="ChEBI" id="CHEBI:58130"/>
            <dbReference type="EC" id="3.1.3.8"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:16990"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the histidine acid phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.8" evidence="4"/>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG04050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034415.1">
        <property type="nucleotide sequence ID" value="XM_018187781.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CBH5"/>
    <dbReference type="STRING" id="1460663.A0A177CBH5"/>
    <dbReference type="GeneID" id="28771267"/>
    <dbReference type="InParanoid" id="A0A177CBH5"/>
    <dbReference type="OrthoDB" id="6509975at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016158">
        <property type="term" value="F:inositol hexakisphosphate 3-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07061">
        <property type="entry name" value="HP_HAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033379">
        <property type="entry name" value="Acid_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016274">
        <property type="entry name" value="Histidine_acid_Pase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20963:SF24">
        <property type="entry name" value="3-PHYTASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20963">
        <property type="entry name" value="MULTIPLE INOSITOL POLYPHOSPHATE PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000894">
        <property type="entry name" value="Acid_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00616">
        <property type="entry name" value="HIS_ACID_PHOSPHAT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00778">
        <property type="entry name" value="HIS_ACID_PHOSPHAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 19" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="20" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="20">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008058057" description="Phytase A" evidence="20">
        <location>
            <begin position="27"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="18">
        <location>
            <position position="83"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="18">
        <location>
            <position position="355"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="34"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="72"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="208"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="259"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="429"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00041857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00042300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00043670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00043675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00043721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00043748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00043788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00044106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00044262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR000894-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR000894-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="OAG04050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="462" mass="50907" checksum="32575A4C4DBBDA46" modified="2016-09-07" version="1">MASSGSMPCLLAALLFTSLTLPRSAAAPTATRACDTVDDGYRCSPKTSHFWGQYSLWFSVPSDVDVDPPEHCDVSFASVLSRHGGRDPTMSKTLLYGATVGLIQNTSTAFPDEFAFLKDYEYNLGADLLTDAGRQEMVNSGAHFYRRYKDFLKGKTPFVRSSGQARVVESANKWLEGYAQAAHKKTGAIDVSIPEAAGVNNTLSHEICTNFEDGPLSDIGNKAQDIWVAKFVPPIQARVNGKLGTTLSTTEIIYLMDLCPFTTLASPTAQISDFCHLFTEDEWQQYDYYESLGKWYGYGNGNPLGPTQGIGYVSELLARLTEKPVQVVGSINSTLDKDFATFPLHRKVYADFSHDNDMTGVLAALGLYNNTKPLSNSTIESTNETKGYSAAWTVPFAARIYVEKLSCKKAKEEFVRIIVNDRVQPLDFCGGDRYGRCTLSKFVESQSFTRTGGHWNQCFTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CC00</accession>
    <name>A0A177CC00_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1178134</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG04278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034643.1">
        <property type="nucleotide sequence ID" value="XM_018180319.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CC00"/>
    <dbReference type="GeneID" id="28763805"/>
    <dbReference type="InParanoid" id="A0A177CC00"/>
    <dbReference type="OrthoDB" id="341259at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG04278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="142" mass="15575" checksum="E6CA4A7B912A0E0B" modified="2016-09-07" version="1">MLNPRGLARPKGFVPMTIPSIYDVVNFSDFKDRMDTPRLGAQVQQESIGKFLEQQAVWAAQDGTRVIHTSSKRMCLSADKPLLAGLDTFCFEITNNALGDEVLENALGCAIRLCTVGALAIQFPSWPPWTAASSAPSWGYRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CC13</accession>
    <name>A0A177CC13_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Amino acid permease/ SLC12A domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_1165229</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG04856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035221.1">
        <property type="nucleotide sequence ID" value="XM_018178672.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CC13"/>
    <dbReference type="STRING" id="1460663.A0A177CC13"/>
    <dbReference type="GeneID" id="28762158"/>
    <dbReference type="InParanoid" id="A0A177CC13"/>
    <dbReference type="OrthoDB" id="3900342at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF39">
        <property type="entry name" value="AMINO ACID TRANSPORTER (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="84"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="128"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="159"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="193"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="240"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="281"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="338"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="384"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="409"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="456"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="483"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="7">
        <location>
            <begin position="49"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAG04856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="562" mass="61597" checksum="7D5EE49814005EAC" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CCH0</accession>
    <name>A0A177CCH0_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NADAR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1206758</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG05335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035700.1">
        <property type="nucleotide sequence ID" value="XM_018182052.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CCH0"/>
    <dbReference type="STRING" id="1460663.A0A177CCH0"/>
    <dbReference type="GeneID" id="28765538"/>
    <dbReference type="InParanoid" id="A0A177CCH0"/>
    <dbReference type="OrthoDB" id="206452at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd15457">
        <property type="entry name" value="NADAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.40">
        <property type="entry name" value="YbiA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012816">
        <property type="entry name" value="NADAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037238">
        <property type="entry name" value="YbiA-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02464">
        <property type="entry name" value="ribofla_fusion"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08719">
        <property type="entry name" value="NADAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143990">
        <property type="entry name" value="YbiA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADAR" evidence="2">
        <location>
            <begin position="46"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG05335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="229" mass="25975" checksum="A0B1D076614CA336" modified="2016-09-07" version="1">MPKAKRKTVARSKASTKSEAPTKSKNPTNSRAVPHIKSPSQSDRVYFHEPSEEHGFLSPWYTSHFTIKTEDYESAAQYILAEKARVFGDKKARQRILEEHDVEVLMTLGENIKGFDEKSWRRRVSRIAKTANMHKFLSDDAESRDLLRQLKKLGTRELVFADPADSDLGIGFSAAEATEVGHAQWGANVFGKAIDEVRKTKAWKDQKASEQRVFDTSIFDVGGRLSVYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CDH6</accession>
    <name>A0A177CDH6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1259087</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG05695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036060.1">
        <property type="nucleotide sequence ID" value="XM_018184881.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CDH6"/>
    <dbReference type="GeneID" id="28768367"/>
    <dbReference type="InParanoid" id="A0A177CDH6"/>
    <dbReference type="OrthoDB" id="10553050at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="198"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG05695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="251" mass="27515" checksum="E7B88FC2B6F18EE0" modified="2016-09-07" version="1">MLVDLSTDAWRCRGVGILGRIRTVNAYRSKGAQVPPSLPAATPSLPPAMPHTPNTALREKQRSAAGFLTFGFILDTVSWALFGYLIHLVHKETDAYYAALQACDSPNPSPSSCNLDPRTHSLPWALTLTLPPLIFSSLTVPIALALALQKRLHPVLILCVAVPSFCLWISLGILNALSSDPYLTENMNPMPVDKWMQGVAGMQCASGAAWLIGMSMAARWVHVHNQEKWATRWMEERARSMEGTGLPPYNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CEK6</accession>
    <name>A0A177CEK6_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">pyridoxal 5'-phosphate synthase (glutamine hydrolyzing)</fullName>
            <ecNumber evidence="3">4.3.3.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CC84DRAFT_1259035</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by PDX2. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively. Also plays an indirect role in resistance to singlet oxygen-generating photosensitizers.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>aldehydo-D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + L-glutamine = pyridoxal 5'-phosphate + L-glutamate + phosphate + 3 H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:31507"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58273"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
            <dbReference type="EC" id="4.3.3.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; pyridoxal 5'-phosphate biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the PdxS/SNZ family.</text>
    </comment>
    <dbReference type="EC" id="4.3.3.6" evidence="3"/>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG05631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035996.1">
        <property type="nucleotide sequence ID" value="XM_018184875.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CEK6"/>
    <dbReference type="FunCoup" id="A0A177CEK6">
        <property type="interactions" value="251"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CEK6"/>
    <dbReference type="GeneID" id="28768361"/>
    <dbReference type="InParanoid" id="A0A177CEK6"/>
    <dbReference type="OrthoDB" id="1660966at2759"/>
    <dbReference type="UniPathway" id="UPA00245"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036381">
        <property type="term" value="F:pyridoxal 5'-phosphate synthase (glutamine hydrolysing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042823">
        <property type="term" value="P:pyridoxal phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008615">
        <property type="term" value="P:pyridoxine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04727">
        <property type="entry name" value="pdxS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000001">
        <property type="entry name" value="Pyridoxine biosynthesis protein PDX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01824">
        <property type="entry name" value="PdxS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001852">
        <property type="entry name" value="PdxS/SNZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033755">
        <property type="entry name" value="PdxS/SNZ_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003215">
        <property type="entry name" value="PRK04180.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00343">
        <property type="entry name" value="pyridoxal 5'-phosphate synthase lyase subunit PdxS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31829">
        <property type="entry name" value="PYRIDOXAL 5'-PHOSPHATE SYNTHASE SUBUNIT SNZ1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31829:SF0">
        <property type="entry name" value="PYRIDOXAL 5'-PHOSPHATE SYNTHASE SUBUNIT SNZ1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01680">
        <property type="entry name" value="SOR_SNZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029271">
        <property type="entry name" value="Pdx1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01235">
        <property type="entry name" value="PDXS_SNZ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51129">
        <property type="entry name" value="PDXS_SNZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0704">Schiff base</keyword>
    <feature type="domain" description="PdxS/SNZ N-terminal" evidence="12">
        <location>
            <begin position="20"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with D-ribose 5-phosphate" evidence="9">
        <location>
            <position position="94"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>D-ribose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>D-ribose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="235"/>
        </location>
        <ligand>
            <name>D-ribose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="256"/>
            <end position="257"/>
        </location>
        <ligand>
            <name>D-ribose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR029271-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR029271-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OAG05631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="315" mass="33501" checksum="FE1F573F5BFF0840" modified="2016-09-07" version="1">MPTELPTTNGNTAQDGENNFAVKAGLARMLKGGVIMDVVNAEQARIAEEAGAVAVMALERVPADIRAQGGVARMSDPQMIKEIMDTVTIPVMAKARIGHFVECQARSPSSLLILEALGVDYIDESEVLTPADAIHHVDKHPFRIPFVCGCRNLGEALRRVSEGAAMIRTKGEAGTGDVIEAVRHMRQVNSDIQKASAMSSTELYTYAKELGVDYALLKETAKLGRLPVVNFAAGGVATPADAALMMQLGCDGVFVGSGIFKSGDAAKRAKAIVQAVTHYKDPKVLMEVSMDLGEAMVGINCGDLGEQEKLAKRGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CEV4</accession>
    <name>A0A177CEV4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1177404</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG05349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035714.1">
        <property type="nucleotide sequence ID" value="XM_018180282.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CEV4"/>
    <dbReference type="STRING" id="1460663.A0A177CEV4"/>
    <dbReference type="GeneID" id="28763768"/>
    <dbReference type="InParanoid" id="A0A177CEV4"/>
    <dbReference type="OrthoDB" id="2310150at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG05349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="220" mass="24593" checksum="44DB80F32BBB8846" modified="2016-09-07" version="1">MATASKSTMPVVLDVMTIGKAGVEGVRVSDLKDVNLMLDVSQSIGHNEIDDARLYGGESSELYPNEGKGMNMGDNVYSHRPEDVRRGLLASLKAIETEKVEKWYLHGPDHTTSLQETLRGENSLCKEGYFECFILATTCPGKQPLSPLAGGFPTSMYKRDMKEDDDESGSRVDPKQWQCRMIIRVKRKEFDLILSGGNVVDYRRGQECSGSGLMRREMKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CEX9</accession>
    <name>A0A177CEX9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Helicase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CC84DRAFT_1206748</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG05317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035682.1">
        <property type="nucleotide sequence ID" value="XM_018182051.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CEX9"/>
    <dbReference type="STRING" id="1460663.A0A177CEX9"/>
    <dbReference type="GeneID" id="28765537"/>
    <dbReference type="InParanoid" id="A0A177CEX9"/>
    <dbReference type="OrthoDB" id="2801544at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050628">
        <property type="entry name" value="SNF2_RAD54_helicase_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626:SF51">
        <property type="entry name" value="SNF2-RELATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase C-terminal" evidence="5">
        <location>
            <begin position="986"/>
            <end position="1140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="865"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1188"/>
            <end position="1234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="867"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="897"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="929"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1188"/>
            <end position="1212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAG05317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="1251" mass="139724" checksum="D2AF221F98CF4743" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CF31</accession>
    <name>A0A177CF31_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Aflatoxin biosynthesis ketoreductase nor-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_1216878</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG05542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035907.1">
        <property type="nucleotide sequence ID" value="XM_018182844.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CF31"/>
    <dbReference type="GeneID" id="28766330"/>
    <dbReference type="InParanoid" id="A0A177CF31"/>
    <dbReference type="OrthoDB" id="9876299at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051468">
        <property type="entry name" value="Fungal_SecMetab_SDRs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43544:SF7">
        <property type="entry name" value="NADB-LER2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43544">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAG05542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="249" mass="25862" checksum="587587D8C2663835" modified="2016-09-07" version="1">MAPSTVVLITGAGRGIGKALTAAYLSYPDHVVIATVRDPKAPKAQELKGLSVGSGSRLLVVGIENTNPEDPKQAVETIEAAGVDHIDVVIANSGISIGAAPLELADPKAFTESFNVNVLSGVVLYQAVSKLLTNSSAPKWISVSSRGGSTSAPLPWYPYAAAYCMSKAAQNWFTQTLHVANASLTAFAIHPGFVLTDMGIAAATGAGIALPETSGDESAGKIIEVIKSATRENTSGKFLDVDTREEIPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CFT3</accession>
    <name>A0A177CFT3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CC84DRAFT_1205357</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG05590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035955.1">
        <property type="nucleotide sequence ID" value="XM_018181970.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CFT3"/>
    <dbReference type="STRING" id="1460663.A0A177CFT3"/>
    <dbReference type="GeneID" id="28765456"/>
    <dbReference type="InParanoid" id="A0A177CFT3"/>
    <dbReference type="OrthoDB" id="2392202at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006369">
        <property type="term" value="P:termination of RNA polymerase II transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00593">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="entry name" value="Ribonuclease III domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014720">
        <property type="entry name" value="dsRBD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000999">
        <property type="entry name" value="RNase_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11207:SF0">
        <property type="entry name" value="RIBONUCLEASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11207">
        <property type="entry name" value="RIBONUCLEASE III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00636">
        <property type="entry name" value="Ribonuclease_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00535">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="RNase III domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50137">
        <property type="entry name" value="DS_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50142">
        <property type="entry name" value="RNASE_3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RNase III" evidence="8">
        <location>
            <begin position="181"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="DRBM" evidence="7">
        <location>
            <begin position="330"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="484"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="17"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="484"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="510"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="533"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="568"/>
            <end position="599"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAG05590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="608" mass="68086" checksum="5E6AEA6A45BE5B9F" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CFV8</accession>
    <name>A0A177CFV8_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Catalase</fullName>
            <ecNumber evidence="3 10">1.11.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CC84DRAFT_1175946</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16 17">
            <text>2 H2O2 = O2 + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:20309"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="EC" id="1.11.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10 12">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the catalase family.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.6" evidence="3 10"/>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG05842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036207.1">
        <property type="nucleotide sequence ID" value="XM_018180182.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CFV8"/>
    <dbReference type="STRING" id="1460663.A0A177CFV8"/>
    <dbReference type="GeneID" id="28763668"/>
    <dbReference type="InParanoid" id="A0A177CFV8"/>
    <dbReference type="OrthoDB" id="6880011at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004096">
        <property type="term" value="F:catalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03132">
        <property type="entry name" value="GATase1_catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.180.10:FF:000003">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.880:FF:000050">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1370.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.180.10">
        <property type="entry name" value="Catalase core domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018028">
        <property type="entry name" value="Catalase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024712">
        <property type="entry name" value="Catalase_clade2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043156">
        <property type="entry name" value="Catalase_clade2_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011614">
        <property type="entry name" value="Catalase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002226">
        <property type="entry name" value="Catalase_haem_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010582">
        <property type="entry name" value="Catalase_immune_responsive"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041399">
        <property type="entry name" value="Catalase_large_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020835">
        <property type="entry name" value="Catalase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42821">
        <property type="entry name" value="CATALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42821:SF1">
        <property type="entry name" value="CATALASE-B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00199">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06628">
        <property type="entry name" value="Catalase-rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18011">
        <property type="entry name" value="Catalase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038927">
        <property type="entry name" value="Catalase_clade2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00067">
        <property type="entry name" value="CATALASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01060">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56634">
        <property type="entry name" value="Heme-dependent catalase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00437">
        <property type="entry name" value="CATALASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51402">
        <property type="entry name" value="CATALASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0349">Heme</keyword>
    <keyword evidence="9 10" id="KW-0376">Hydrogen peroxide</keyword>
    <keyword evidence="8 10 12" id="KW-0408">Iron</keyword>
    <keyword evidence="6 10 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 10" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Catalase core" evidence="13">
        <location>
            <begin position="42"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="92"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="165"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="12">
        <location>
            <position position="379"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR038927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR038927-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR038927-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OAG05842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="741" mass="82919" checksum="08D8586FD9DD19B5" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CFX5</accession>
    <name>A0A177CFX5_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Probable Xaa-Pro aminopeptidase P</fullName>
            <ecNumber evidence="5">3.4.11.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Aminoacylproline aminopeptidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Prolidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CC84DRAFT_1164108</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of any N-terminal amino acid, including proline, that is linked to proline, even from a dipeptide or tripeptide.</text>
            <dbReference type="EC" id="3.4.11.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the peptidase M24B family.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.9" evidence="5"/>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG05630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035995.1">
        <property type="nucleotide sequence ID" value="XM_018178413.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CFX5"/>
    <dbReference type="FunCoup" id="A0A177CFX5">
        <property type="interactions" value="384"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CFX5"/>
    <dbReference type="GeneID" id="28761899"/>
    <dbReference type="InParanoid" id="A0A177CFX5"/>
    <dbReference type="OrthoDB" id="9995434at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01085">
        <property type="entry name" value="APP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.350.10:FF:000010">
        <property type="entry name" value="Probable Xaa-Pro aminopeptidase P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.350.10:FF:000003">
        <property type="entry name" value="Xaa-pro aminopeptidase P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.230.10:FF:000007">
        <property type="entry name" value="Xaa-Pro aminopeptidase P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000587">
        <property type="entry name" value="Creatinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033740">
        <property type="entry name" value="Pept_M24B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032416">
        <property type="entry name" value="Peptidase_M24_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001131">
        <property type="entry name" value="Peptidase_M24B_aminopep-P_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050422">
        <property type="entry name" value="X-Pro_aminopeptidase_P"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43763">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43763:SF6">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01321">
        <property type="entry name" value="Creatinase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16189">
        <property type="entry name" value="Creatinase_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16188">
        <property type="entry name" value="Peptidase_M24_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00491">
        <property type="entry name" value="PROLINE_PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 19" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0464">Manganese</keyword>
    <keyword evidence="9 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="8" id="KW-0645">Protease</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Creatinase N-terminal" evidence="17">
        <location>
            <begin position="49"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M24" evidence="16">
        <location>
            <begin position="362"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M24 C-terminal" evidence="18">
        <location>
            <begin position="592"/>
            <end position="653"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00020658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00030849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00032413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF01321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF16188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="OAG05630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="654" mass="73009" checksum="67FAC3162037CC7E" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CGG8</accession>
    <name>A0A177CGG8_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1090895</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG05850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036215.1">
        <property type="nucleotide sequence ID" value="XM_018174380.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CGG8"/>
    <dbReference type="GeneID" id="28757866"/>
    <dbReference type="InParanoid" id="A0A177CGG8"/>
    <dbReference type="OrthoDB" id="3535998at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37012">
        <property type="entry name" value="B-ZIP TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="163"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="285"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="163"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="201"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG05850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="352" mass="38855" checksum="A242E047F0FD5F9D" modified="2016-09-07" version="1">MASMNRSPVYDDHSSGSERKQSTPGAKKRPSRAGTRSVTTLTAAQLERKRANDREAQRAIRQRTKDHIESLERQVRDLTAQIGTNSSTKMMELMRRNEELEQENALLRARLSHAGQALGMLEGAGAPSPSDRIQILSHARRSSTGTARSVHSVPEITTTPVAQPAPWQQQQQHPQPPQHQQHAYSPNVPSPHVEHPPTNWSSHPSAHPSQHPVSLSVPDSSLHAVESGNMPYPTPYSMDHNTRAMSYPLENASLVTSQAMQIGGYNTPTSNPSAHSSDYHRQMSVPMNNASPAGHGQHPHSYSSPAHHGYVPQSSHPGEMHMMAPASHQQSHMVNEQGQMMYHLPPHMKVEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CH69</accession>
    <name>A0A177CH69_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1164596</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG06292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036657.1">
        <property type="nucleotide sequence ID" value="XM_018178519.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CH69"/>
    <dbReference type="STRING" id="1460663.A0A177CH69"/>
    <dbReference type="GeneID" id="28762005"/>
    <dbReference type="InParanoid" id="A0A177CH69"/>
    <dbReference type="OrthoDB" id="47007at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051019">
        <property type="entry name" value="VLCFA-Steroid_DH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43899">
        <property type="entry name" value="RH59310P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43899:SF13">
        <property type="entry name" value="RH59310P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG06292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="355" mass="39254" checksum="CEA2B4C1DB19268F" modified="2016-09-07" version="1">MRRGFLLIQKGRTRDWTSATQRIARQIKFTSPGLLRKKNQCIISWSSLVFLTNPTPTISSTMPLPLVHYLYRSGLPKYFRQDSNGESSWALVTGASDGIGWELSRQLAERGFNVILHGRNTAKLSRCRSELEASFPARHFRTIAVDASAFTDADIDRIVATTTDIPLTILVNNVGGTAPLSSNFKHFEDYTTAEIDAVFSLNITFPLKLTRAILPRFQAQSSPTLVLTCGSQSQIGQAYVAGYSATKGALHTWSRALAAEQYESKSQVEILEVIVGGTYTQQLQKDPNMKPGVFMPTAEIMARAALARVGHGHRWVVGYWGHWVQGFLLYTCLPGWMADSVVAGILKPSVEAKKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CIX6</accession>
    <name>A0A177CIX6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1163624</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG07474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037839.1">
        <property type="nucleotide sequence ID" value="XM_018178308.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CIX6"/>
    <dbReference type="GeneID" id="28761794"/>
    <dbReference type="InParanoid" id="A0A177CIX6"/>
    <dbReference type="OrthoDB" id="10533120at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG07474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="109" mass="12130" checksum="5993C6F34907D42F" modified="2016-09-07" version="1">MPVQCICLQRGCSTHVPIKKARSKHAFAHIPLTILKDRLYKWSMQVIGDDNALREVRLQPQSVGNLNIAEEHSQGENKRAKHDRVISGSTVEDCGAKARDFRSAALPQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CJ25</accession>
    <name>A0A177CJ25_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Pre-mRNA-splicing factor SLU7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CC84DRAFT_1163164</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in pre-mRNA splicing.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Associated with the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the SLU7 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG06858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037223.1">
        <property type="nucleotide sequence ID" value="XM_018178194.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CJ25"/>
    <dbReference type="FunCoup" id="A0A177CJ25">
        <property type="interactions" value="475"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CJ25"/>
    <dbReference type="GeneID" id="28761680"/>
    <dbReference type="InParanoid" id="A0A177CJ25"/>
    <dbReference type="OrthoDB" id="249612at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030628">
        <property type="term" value="F:pre-mRNA 3'-splice site binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021715">
        <property type="entry name" value="Slu7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039974">
        <property type="entry name" value="Splicing_factor_SLU7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12942:SF2">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR SLU7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12942">
        <property type="entry name" value="STEP II SPLICING FACTOR SLU7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11708">
        <property type="entry name" value="Slu7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5 7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Pre-mRNA-splicing factor SLU7" evidence="9">
        <location>
            <begin position="117"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="152"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="422"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="152"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="171"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="425"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF11708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAG06858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="477" mass="54114" checksum="78B9ADDF2E723CF7" modified="2016-09-07" version="1">MPPAQPRKPDVSAAAKERNEYIPSFISKKPFYAVDENGEDGDYLEHQRLQKQEQDSKWYDRGKKIGPAATKYRKGACENCGAMTHKKKDCLSRPRKTGAKFTGKNIEADEAVEDVQLGWDAKRDRWNGYDAANFTEVIEEYNELEEMRKKAKEAAKGDQKSGDEEEDEGDRYDAETDMGRKQATSTRNLRLREDTAKYLLNLDLDSAKYDPKTRSMVDTGATADNAAALVAEEGFMKASGDAAEFERAQRYAWETQERGDRNKVHLQANPTSGELMRKKELQEAEETKAAKQKALMDKYGGQDKFNDDTLRRVGVTENERYVEYDERGRIKGAPKVKAKSKYPEDVLIHNHTSVWGSWWASFQWGYACCHSTVKNSYCTGSAGKEAFEAAERMRLGADAPDVDEIPKAIAQIEDAALKKHVPNTAEKDDKATRDDKRKRTLEEMRDGVTEAEMEEYRRKRQMAADPMANFLASKEAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CJ76</accession>
    <name>A0A177CJ76_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">37S ribosomal protein S25, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CC84DRAFT_1088059</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="6">Component of the mitochondrial small ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mS23 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG07366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037731.1">
        <property type="nucleotide sequence ID" value="XM_018174233.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CJ76"/>
    <dbReference type="FunCoup" id="A0A177CJ76">
        <property type="interactions" value="113"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CJ76"/>
    <dbReference type="GeneID" id="28757719"/>
    <dbReference type="InParanoid" id="A0A177CJ76"/>
    <dbReference type="OrthoDB" id="5542239at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016939">
        <property type="entry name" value="Ribosomal_mS23_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37799">
        <property type="entry name" value="37S RIBOSOMAL PROTEIN S25, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37799:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13741">
        <property type="entry name" value="MRP-S25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029764">
        <property type="entry name" value="RSM25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 6 7" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR029764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAG07366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="245" mass="28572" checksum="C2DBDB10255DE727" modified="2016-09-07" version="1">MGRYDFRPMRVRQTAKALFDSRRNASLPQWYNIIGDIPPSETLARPLQRAPTPKKARKPSRMFQPLPIAYPEDKLRSDFFGDHPWELARPRIIVEDSGNDSKHHDWSNIVQPGKQLDGESVVQRQMWLMKHRAMSKPTAYDVARREFYFHRHRDDIRRRVAREEALHCGAYFGKGPLEIGMELEDNVWENWKSWAREQIDDEEAARAQMFSGVPSESTSLESTEFEASLEEVQAEPSVLGKNFQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CJ80</accession>
    <name>A0A177CJ80_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GRAM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1088757</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG06918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037283.1">
        <property type="nucleotide sequence ID" value="XM_018174270.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CJ80"/>
    <dbReference type="STRING" id="1460663.A0A177CJ80"/>
    <dbReference type="GeneID" id="28757756"/>
    <dbReference type="InParanoid" id="A0A177CJ80"/>
    <dbReference type="OrthoDB" id="1708389at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037847">
        <property type="entry name" value="GRAMDC4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37402">
        <property type="entry name" value="GRAM DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37402:SF1">
        <property type="entry name" value="GRAM DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="306"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="405"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG06918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="610" mass="69377" checksum="D8F6BA0ABA34CE78" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CJS0</accession>
    <name>A0A177CJS0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">UV-endonuclease UvdE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_1163326</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG07089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037454.1">
        <property type="nucleotide sequence ID" value="XM_018178240.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CJS0"/>
    <dbReference type="STRING" id="1460663.A0A177CJS0"/>
    <dbReference type="GeneID" id="28761726"/>
    <dbReference type="InParanoid" id="A0A177CJS0"/>
    <dbReference type="OrthoDB" id="541883at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043504">
        <property type="term" value="P:mitochondrial DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009411">
        <property type="term" value="P:response to UV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.150">
        <property type="entry name" value="Divalent-metal-dependent TIM barrel enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004601">
        <property type="entry name" value="UvdE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00629">
        <property type="entry name" value="uvde"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31290">
        <property type="entry name" value="UV-DAMAGE ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31290:SF5">
        <property type="entry name" value="UV-DAMAGE ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03851">
        <property type="entry name" value="UvdE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="Xylose isomerase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0228">DNA excision</keyword>
    <keyword evidence="6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="2 8" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="279"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="597"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="673"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="19"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="56"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="94"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="213"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="279"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="602"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="616"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="712"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="762"/>
            <end position="771"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAG07089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="792" mass="86874" checksum="A3E052BFE03E7A82" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CJW4</accession>
    <name>A0A177CJW4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cell division/GTP binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_1204994</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG07541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037906.1">
        <property type="nucleotide sequence ID" value="XM_018181946.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CJW4"/>
    <dbReference type="FunCoup" id="A0A177CJW4">
        <property type="interactions" value="221"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CJW4"/>
    <dbReference type="GeneID" id="28765432"/>
    <dbReference type="InParanoid" id="A0A177CJW4"/>
    <dbReference type="OrthoDB" id="416553at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032161">
        <property type="term" value="C:cleavage apparatus septin structure"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005940">
        <property type="term" value="C:septin ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000921">
        <property type="term" value="P:septin ring assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043934">
        <property type="term" value="P:sporulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01850">
        <property type="entry name" value="CDC_Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000260">
        <property type="entry name" value="Cell division control 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030379">
        <property type="entry name" value="G_SEPTIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016491">
        <property type="entry name" value="Septin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18884">
        <property type="entry name" value="SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00735">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006698">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51719">
        <property type="entry name" value="G_SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1 8" id="KW-0132">Cell division</keyword>
    <keyword evidence="3 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Septin-type G" evidence="7">
        <location>
            <begin position="34"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="312"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="332"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAG07541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="342" mass="39075" checksum="D25C0F26CC850BA9" modified="2016-09-07" version="1">MATAYGAPQPSVYPESYVGFDSITKQIEKKLVKRGFQFNVICVGQTGLGKSTLINTIFASHLIDSKGRMQPDEPIRQTTEIQAVSHTIEENGVRLRLNIVDTPGYGDLINNERCWDPIVKYIKDQHSAYLRKELTAQRERYLQDTRIHCCLFFINPSGHGLKPIDIVVLKKLSEFVNVVPVIAKSDSLTLEERAEFKERIKEEFAFHNLRMYPYDNEEHDQEEVALNTSIKSIIPFAVVGSEKNIVVNGKQVRGRQNRWGFINVEDENHCEFVYLRNFLTRTHLQDLIETTSQIHYESFRAKQLLALKESSAVGGGHSSRPISPAADRELSRNSQRMTMNGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CK33</accession>
    <name>A0A177CK33_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_644322</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG07209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037574.1">
        <property type="nucleotide sequence ID" value="XM_018186994.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CK33"/>
    <dbReference type="GeneID" id="28770480"/>
    <dbReference type="InParanoid" id="A0A177CK33"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG07209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="202" mass="22710" checksum="3414A0FC9C1BCF9D" modified="2016-09-07" version="1">MLTCQAEATASFSSVTGRKLPLKLPMPTCLTTMTRIRTSMPRSTGPTVPRRTLAKRRLGHKARKRPPNHLLPSRQKSQRSRLQPRRTRLCQRRLLVQVKSNQRNLYSLARVSCLDREALEHALYPPVVLVILASRWVGPGTASASGNIVHVMTLMRWVMDWMLSAFLGRGLGLIWQAYAGMDKAKSLTGSSYPKRGSLVHEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2023-06-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CKH4</accession>
    <name>A0A177CKH4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1175265</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG07462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037827.1">
        <property type="nucleotide sequence ID" value="XM_018180141.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CKH4"/>
    <dbReference type="GeneID" id="28763627"/>
    <dbReference type="InParanoid" id="A0A177CKH4"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG07462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="271" mass="30152" checksum="C786C4E07A54F612" modified="2016-09-07" version="1">MGNMFPTDPSAWQTYFSEFSLESLPQVSSATEDEHSRNEKFVRDMYVDITSLDLSGRKYIYIICDVAAFGTSASTLQLPSDGLLVIYARFFTAAAPITLKFETGTLQIYAAETNQTISVNEYQVTVCSQAIQAWRLFDKHIASCKRIMSSLVPLLSPAFLEVNTMKGAWQSTTNDLDGLIETIDHIDVVTLDAVMRDIQTVALLGLWEDLKKHVKFANMTLPRQTFPRGTCIDCGRDVQRSSKLPPSKVNNEYPTKATGASSICSGVYQMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CKP3</accession>
    <name>A0A177CKP3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_655706</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG07367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037732.1">
        <property type="nucleotide sequence ID" value="XM_018187027.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CKP3"/>
    <dbReference type="GeneID" id="28770513"/>
    <dbReference type="InParanoid" id="A0A177CKP3"/>
    <dbReference type="OrthoDB" id="10587027at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="177"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="9"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="59"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG07367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="206" mass="21889" checksum="C4379F70A9584501" modified="2016-09-07" version="1">MTRKRSASRRSSGSSSNSSSHLARAALEAIQRVYTSRSVQISPSASPTSTTRESFEPAPSDTLSSMHSSSSTITPPAGYPTAHHQTAPAPTERTPLLSTFSPVVSPLGPSKSFSPGHTHPPEPFPDLEPGPGSPSDSSYEGLDVFGTHQPRRRWDLGASGGGGGQLRQNKRCEAWDACLLIYFFAVFVLVTVGGGAVLFWVLLHQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CKQ0</accession>
    <name>A0A177CKQ0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HET-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1184913</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG07811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038176.1">
        <property type="nucleotide sequence ID" value="XM_018180777.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CKQ0"/>
    <dbReference type="STRING" id="1460663.A0A177CKQ0"/>
    <dbReference type="GeneID" id="28764263"/>
    <dbReference type="InParanoid" id="A0A177CKQ0"/>
    <dbReference type="OrthoDB" id="674604at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF10">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="27"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG07811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="256" mass="29548" checksum="961D9B0EB8FF7B31" modified="2016-09-07" version="1">MRLLKYTSDGGLGLTEDLTTDEKVPPYAILSHTWQKGQEWTFDDLSSGNGKHKTGYQKVLFCAQQARRDGLDYCWVDTCCINKSSSAELSEAINSMFRWYQNSKKCYVYLLDVSCRDFANGGQSFRKSRWFTRGWTLQELIAPACVEFYSLEGKQIGDKSSLVQDIHSITGIPIQALQGCPLPQFSIDERMSWAKNRHTEREEDAAYSLLGIFDIHIPLLYGEKREKAFARLKRKIMKSFEARPRRRMLFTPPKRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CKQ3</accession>
    <name>A0A177CKQ3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SGNH hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CC84DRAFT_1075932</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 'GDSL' lipolytic enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG07377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037742.1">
        <property type="nucleotide sequence ID" value="XM_018173717.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CKQ3"/>
    <dbReference type="STRING" id="1460663.A0A177CKQ3"/>
    <dbReference type="GeneID" id="28757203"/>
    <dbReference type="InParanoid" id="A0A177CKQ3"/>
    <dbReference type="OrthoDB" id="2141316at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037459">
        <property type="entry name" value="RhgT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43695">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_2G17250)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43695:SF1">
        <property type="entry name" value="RHAMNOGALACTURONAN ACETYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SGNH hydrolase-type esterase" evidence="4">
        <location>
            <begin position="31"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAG07377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="278" mass="29140" checksum="6D7A8F8122820F58" modified="2016-09-07" version="1" fragment="single">LIAAASALPGRHQGPSPTSSSVKAIPTIWLAGDSTTAPGGGHNGTEGWGQYLKYSFGDNAFVNNSAYAGRSARSFTREGRFDRIAAAMKPGDFVVIELGINDPGKPTNGSTSTTGDKGRADCPGAGNETCTVIFNNVTEIVQTFPTYIETAAKKFLSLGAASVIISEQLPTNVWESGSYSYKPSIFSYYDLLVTDRLGGPAGKAYLVQHGSYAAQAQKLLGAEVVDANYPMDHTHTAPFLADVHSQAFVLGLKCGTSPLGNLVVNATARIEASRGPCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CKV2</accession>
    <name>A0A177CKV2_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mid2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_1186441</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG07498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037863.1">
        <property type="nucleotide sequence ID" value="XM_018180860.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CKV2"/>
    <dbReference type="STRING" id="1460663.A0A177CKV2"/>
    <dbReference type="GeneID" id="28764346"/>
    <dbReference type="InParanoid" id="A0A177CKV2"/>
    <dbReference type="OrthoDB" id="5425782at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008058307" description="Mid2 domain-containing protein" evidence="3">
        <location>
            <begin position="20"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="199"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="241"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="45"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="251"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAG07498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="276" mass="27560" checksum="5017F3A1E6463F37" modified="2016-09-07" version="1">MRSSWLLFVLMALVALSAAFSVEDALHIDGINAYLHHGEKRQAQGTGASSSADAPSSSAQAPSSTADEPSSTAAAPSTSAPSTTAAEPSSSDTTPTSAAQPSQESSSANADPSTTDASAASKTSAKASASLSTKALVSTEVAPVTTILTRTLTNGQTSLETSVGSRTVEHTTGSTVETALPTTQASSSSSGLSSTNKSIIGGVVGGVGGAILLGGIALVCWRMWGKKKRVTEDDADLMAGTGSALGDKSHSSASPFQSNLEQYHNPGGRPNAAANF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CKY8</accession>
    <name>A0A177CKY8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1175313</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG07520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037885.1">
        <property type="nucleotide sequence ID" value="XM_018180143.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CKY8"/>
    <dbReference type="GeneID" id="28763629"/>
    <dbReference type="InParanoid" id="A0A177CKY8"/>
    <dbReference type="OrthoDB" id="3801064at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG07520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="251" mass="28139" checksum="F8154462F64F2C40" modified="2016-09-07" version="1">MHLRKHDKDLWQARGATPDWSLVDCNCTKPDKYDYGEEYGCEDDPLYPPQECSEGAWEGAKACVGLFTFGSAYGITPLREDALDRLCWYYNEVRTIGLAEIEDPAVGDDNWELTDPILPLPAKHCEHAYNQTPPGSPLRKLLVRAFCASHQPGHRGKFICVGFKTCCDFSTVYLHKDILQPVDPPQELLADVAACFASGVSSTYVVKGEDIACEKYPVLPPSDFHAHNSEQERQHCSKLPVDPNTRVHIEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CL29</accession>
    <name>A0A177CL29_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">PQ-loop-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CC84DRAFT_1258582</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-histidine(out) + L-arginine(in) = L-histidine(in) + L-arginine(out)</text>
            <dbReference type="Rhea" id="RHEA:71063"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the laat-1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG07497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037862.1">
        <property type="nucleotide sequence ID" value="XM_018184840.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CL29"/>
    <dbReference type="GeneID" id="28768326"/>
    <dbReference type="InParanoid" id="A0A177CL29"/>
    <dbReference type="OrthoDB" id="8048523at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098852">
        <property type="term" value="C:lytic vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015174">
        <property type="term" value="F:basic amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034486">
        <property type="term" value="P:vacuolar transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.290:FF:000009">
        <property type="entry name" value="PQ loop repeat family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.290:FF:000012">
        <property type="entry name" value="Vacuolar membrane PQ loop repeat protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.290">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051415">
        <property type="entry name" value="LAAT-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006603">
        <property type="entry name" value="PQ-loop_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16201:SF44">
        <property type="entry name" value="SEVEN TRANSMEMBRANE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16201">
        <property type="entry name" value="SEVEN TRANSMEMBRANE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04193">
        <property type="entry name" value="PQ-loop"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00679">
        <property type="entry name" value="CTNS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="78"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="175"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="215"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="252"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="283"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="110"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00050768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAG07497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="316" mass="33977" checksum="33ED9AE3FC593D5C" modified="2016-09-07" version="1">MNVTIAGHGPHLTTHEALSGVFGSISLASWIFLLVPQLIENYRQSSADGISLAFLAVWFIGDVTNLAGALWAQLVPTVSALAVYFCFADLVLIAQCVYYNAKNARRAARKASTRSEDSVEQPLLGRRDSSNVGLPGSHTRRRSSAASARERRRRASSLPSLVEEEARGSAWVKNAISIVGVCAVGAAGWAIAWKTGVWVPTPEHGASPSDPEPDTPLGASILGYVSAVCYLGARIPQIVKNQRERSCEGLSLLFFILSLLGNATYGAGILFHSLEKEYFLTNLPWLIGSLGTIVEDVIIFIQFRVFGTGESSAVEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CL43</accession>
    <name>A0A177CL43_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="16">26S protease regulatory subunit 8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CC84DRAFT_1257150</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AAA ATPase family. BCS1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038620.1">
        <property type="nucleotide sequence ID" value="XM_018184701.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CL43"/>
    <dbReference type="FunCoup" id="A0A177CL43">
        <property type="interactions" value="1118"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CL43"/>
    <dbReference type="GeneID" id="28768187"/>
    <dbReference type="InParanoid" id="A0A177CL43"/>
    <dbReference type="OrthoDB" id="10251412at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034551">
        <property type="term" value="P:mitochondrial respiratory chain complex III assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19510">
        <property type="entry name" value="RecA-like_BCS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000768">
        <property type="entry name" value="Probable mitochondrial chaperone bcs1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057495">
        <property type="entry name" value="AAA_lid_BCS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014851">
        <property type="entry name" value="BCS1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050747">
        <property type="entry name" value="Mitochondrial_chaperone_BCS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23070">
        <property type="entry name" value="BCS1 AAA-TYPE ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25426">
        <property type="entry name" value="AAA_lid_BCS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08740">
        <property type="entry name" value="BCS1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01024">
        <property type="entry name" value="BCS1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="4 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="BCS1 N-terminal" evidence="15">
        <location>
            <begin position="49"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="14">
        <location>
            <begin position="270"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OAG08255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="490" mass="54557" checksum="0EA81674BC1C1643" modified="2016-09-07" version="1">MDSPNPSPAPPSPSQQLAKHAPVEGSDGFSSYFSQLTGNPFFTAGFGLAALATVGRIGQKSLVQGASLLRRRMLVDIEITHHDEAYPWLLLWMTNFHRSQLAGAQQASQGGILSSIVQRINPRLHHLQVSTAQSKSGSPRSAHFAFVPGHGQHILRYGSSFVLVDRQRQKSYNMSTGVPFETIRMTTLYSHRRVFEDIFAEAHEMHQQLQEGKTTIHTSNGMDWKPFGEPKRKRPLQSIVLERGVKERIVEDVEAFIKARTWYLDRGIPYRRGYLLYGPPGTGKSSFIQALAGHLDYDIAILNVSERGLHDDKLSHMLSRVPPRTIVLLEDIDVAFANRKQADAEGYSGANVTFSGLLNALDGVASGEERIIFLTTNYVERLDEALIRPGRVDMTVRLGEATEYQIGELWDRFYAEFDTEGAGKKQFLAKTNRLGLTNTVSTAALQGLFLYNKDDPEGAIKMVQGLTAGHPRRAEDHVELPGHVDVNDVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CLA5</accession>
    <name>A0A177CLA5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Class I glutamine amidotransferase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1162284</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038680.1">
        <property type="nucleotide sequence ID" value="XM_018177954.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CLA5"/>
    <dbReference type="GeneID" id="28761440"/>
    <dbReference type="InParanoid" id="A0A177CLA5"/>
    <dbReference type="OrthoDB" id="543156at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052158">
        <property type="entry name" value="INH-QAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43130">
        <property type="entry name" value="ARAC-FAMILY TRANSCRIPTIONAL REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43130:SF7">
        <property type="entry name" value="DJ-1_PFPI DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DJ-1/PfpI" evidence="1">
        <location>
            <begin position="51"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG08315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="234" mass="25902" checksum="A3652BDCCBC45B65" modified="2016-09-07" version="1">MTTSIPNAKSKPLRIGVLYEEVQLTDLAGLDILGNMSSRIVNMVTNLIPAMEKLKPYARDMEFLYISSSLEPAWATPDMFIRPTHTYESAPRDLDIILIGGPDPQKVPEASLTFLREASKQTKAILTTCTGGMWLAKSGVLDGKKATTNRILLEPARHVFPNVEWQDERWVTVDGHFEGAQLWTAGGAKCGIDMVIEYALQNFHEQLVASSCGSLEFEIEGRSKSYKGPFVPVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CLJ8</accession>
    <name>A0A177CLJ8_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">choline-phosphate cytidylyltransferase</fullName>
            <ecNumber evidence="9">2.7.7.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">CTP:phosphocholine cytidylyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Phosphorylcholine transferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CC84DRAFT_704536</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytidylyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.15" evidence="9"/>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG07657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038022.1">
        <property type="nucleotide sequence ID" value="XM_018187113.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CLJ8"/>
    <dbReference type="STRING" id="1460663.A0A177CLJ8"/>
    <dbReference type="GeneID" id="28770599"/>
    <dbReference type="InParanoid" id="A0A177CLJ8"/>
    <dbReference type="OrthoDB" id="17102at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004105">
        <property type="term" value="F:choline-phosphate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031210">
        <property type="term" value="F:phosphatidylcholine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02174">
        <property type="entry name" value="CCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000147">
        <property type="entry name" value="Cholinephosphate cytidylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041723">
        <property type="entry name" value="CCT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045049">
        <property type="entry name" value="Pcy1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10739:SF13">
        <property type="entry name" value="CHOLINE-PHOSPHATE CYTIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10739">
        <property type="entry name" value="CYTIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="7" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cytidyltransferase-like" evidence="13">
        <location>
            <begin position="133"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00026101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00076205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00080967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OAG07657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="457" mass="50795" checksum="37F9B711E35EF0E8" modified="2016-09-07" version="1">MPPKRKRTNTVSSVKNAAMDVAQPSSRDASDEGAEDSVLQQVTSKKERQADSHVSAKRTRTEKNADGENGDVDGQPDRASKKSKTSNSGDEGDHGVNGEAGTMRMAPPPKAGLVDPVGYKTNPPPEGRPVRVYADGVFDLFHLGHARALQQAKTAFPETHLIVGVTGNEETHRRKGLTVLSAAERAESVRHCKWVDEVIEDCPWIVTAEFLEQHGIDYVAHDDLPYGADEGDDIYKPIKEKGMFLVTQRTEGLSTTGIITKIVRDYDQYIDRQLKRGTSRKELNVSWLKKNELEFKRNMVELRDSIKNNWATTGQELTKDFRQFWQSSRPASPARTPTRERTERELAASATSPSALSHLSHLEIPGRASERGSSEFAAGYNLGLIGGVRSWVSTSLYVVRRGLIYDRWHAVAATSTTAAHRALRMKTAQTSMKQARRKRHVVGLANNLQKWTRGCNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CLQ7</accession>
    <name>A0A177CLQ7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1203846</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038849.1">
        <property type="nucleotide sequence ID" value="XM_018181856.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CLQ7"/>
    <dbReference type="STRING" id="1460663.A0A177CLQ7"/>
    <dbReference type="GeneID" id="28765342"/>
    <dbReference type="InParanoid" id="A0A177CLQ7"/>
    <dbReference type="OrthoDB" id="25896at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008058345" evidence="2">
        <location>
            <begin position="27"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="328"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="288"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="328"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="356"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG08484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="604" mass="67143" checksum="B9492109AE6CF57F" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CLY8</accession>
    <name>A0A177CLY8_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Fatty acid hydroxylase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_1194697</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038898.1">
        <property type="nucleotide sequence ID" value="XM_018181363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CLY8"/>
    <dbReference type="STRING" id="1460663.A0A177CLY8"/>
    <dbReference type="GeneID" id="28764849"/>
    <dbReference type="InParanoid" id="A0A177CLY8"/>
    <dbReference type="OrthoDB" id="408954at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006694">
        <property type="entry name" value="Fatty_acid_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050307">
        <property type="entry name" value="Sterol_Desaturase_Related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11863">
        <property type="entry name" value="STEROL DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04116">
        <property type="entry name" value="FA_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="107"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid hydroxylase" evidence="7">
        <location>
            <begin position="164"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="317"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="326"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAG08533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="337" mass="37345" checksum="C8ECEC5BBA2F358C" modified="2016-09-07" version="1">MSLSSLLTPLTLPLASLLALPLLSSWSTSLNLLFISLTWTTLALSYSPLQLEFFGPLLLRSTLYLLPSLLFLSFDTLIPSLAVEFKAQGERGLPARQRGGAGKIRNVVFWSVANVLLGVALQGGIEFLVTDGLRMRSLLVVKGSRWSLNHLPNPWGVVKHLGMGIVSRNILQYYIHRDLLHSTTGGFIARLHQEWHHSVTAPYSFVAAYDHPLPYLLHRFLPLYLPAITFRFHLTTYLIMIALTSLEELFTYSGYSVLPSTIMLKGMARRVDAHMRSGGEGNFGPLGVLDWINGTTLGGRNVTDDLGDEVEKHHVEERANGMASKLKSKARKGKGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CM63</accession>
    <name>A0A177CM63_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1215086</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038968.1">
        <property type="nucleotide sequence ID" value="XM_018182695.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CM63"/>
    <dbReference type="STRING" id="1460663.A0A177CM63"/>
    <dbReference type="GeneID" id="28766181"/>
    <dbReference type="InParanoid" id="A0A177CM63"/>
    <dbReference type="OrthoDB" id="5427833at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="124"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="248"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="124"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="192"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG08603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="300" mass="30993" checksum="A506F46268120DAD" modified="2016-09-07" version="1">MAMALVPTGVTTDIEAVSLSKFVPRIENLPQSCQVAYNTSIQGCTRADFPKERNEAINNCSNDCVQGLIQIVQLVNQQCSTVRVPADSIIGVALSGDLLPKLCGNIVVVTSGQQTYAQSTLATSTTSSTSTAASTTQQAQSSSTQATDSAQSTPSSTAASSVASSPSRSIQPPSSTQQGITIDTATPPPAPSQTAIGQKSNPDSAGGSPFDVTFSTSSSSHLQLGGLEMTAMLLAASATTAAPTVVAIEQLASLKKELESAIKRADKEEAAHLQLQNRLQRAEAAEAKAKAAESTWRLAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CMD9</accession>
    <name>A0A177CMD9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_579669</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038831.1">
        <property type="nucleotide sequence ID" value="XM_018186743.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CMD9"/>
    <dbReference type="STRING" id="1460663.A0A177CMD9"/>
    <dbReference type="GeneID" id="28770229"/>
    <dbReference type="InParanoid" id="A0A177CMD9"/>
    <dbReference type="OrthoDB" id="433474at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF8">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="3">
        <location>
            <begin position="88"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="3">
        <location>
            <begin position="272"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="441"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="453"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAG08466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="466" mass="51274" checksum="B7192B084BAA87BD" modified="2016-09-07" version="1">MTADNAPAERFGRPRWLLHVQAEIWRFLMGIGMMLHKLARPLPPKPSFNRNIESTVSPLKGNFKLHFYVPKDYNRVKKLKGAKRYPCVINFHGGGFVLGSALDDARWAGVVVQQVGAIVVSVDYRCAPEFPFPTAVEDGADAVLYLAQHADEFLIDPSRFAISGFSSGGNMSFTVPLCLQGELLDRSQSGEKIENPARKGSVPAINILAPPTKVHLRVPPPANSSGSRVALSRTPTGNSRLDRIAMLRSTGHSALSLVSSYKEGSAVAVATQGSTAEAKIRGIVSFYPPTDYTQTRAQRRATCSRADQLLPAVFTELFDDSYLQPPALDLSHPWLSPGVAPDAMLTALPDDIVLFCCEWDMLLAEGEQFRDRLKNGLGKRVHYHKVPGVPHGWDKAPNPLRESPGARDQYKVACRELKRMFEIEEEDVEGDLCECSTHAERDEEASIGMGSLKEVHTKESAREGTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CMP7</accession>
    <name>A0A177CMP7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Myb-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1257567</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039148.1">
        <property type="nucleotide sequence ID" value="XM_018184747.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CMP7"/>
    <dbReference type="STRING" id="1460663.A0A177CMP7"/>
    <dbReference type="GeneID" id="28768233"/>
    <dbReference type="InParanoid" id="A0A177CMP7"/>
    <dbReference type="OrthoDB" id="5403747at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG08783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="183" mass="19700" checksum="E0250E687B6FBB3B" modified="2016-09-07" version="1">MSDSGNDAGDSGSSSGPSFTEREMQMLAWAMQSLKSGPPDIDYEKLAQYAGMTNPRSAGNAWAKIRNKLNAATDGAIATPKKTSQKKKAAAKAEKTYDDADGEPETPKKATPRKRTPKKQEVDGEEASPKKRGRPARPKNKKSSDEEEAAAVETEATADDKVNEKMEDVDDGKPEATPAQEEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CMX7</accession>
    <name>A0A177CMX7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mitochondrial genome maintenance protein MGM101</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CC84DRAFT_1086196</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
            <location evidence="1">Mitochondrion nucleoid</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MGM101 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038492.1">
        <property type="nucleotide sequence ID" value="XM_018174147.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CMX7"/>
    <dbReference type="FunCoup" id="A0A177CMX7">
        <property type="interactions" value="249"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CMX7"/>
    <dbReference type="GeneID" id="28757633"/>
    <dbReference type="InParanoid" id="A0A177CMX7"/>
    <dbReference type="OrthoDB" id="17164at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000262">
        <property type="term" value="C:mitochondrial chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000725">
        <property type="term" value="P:recombinational repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009446">
        <property type="entry name" value="Mgm101"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31404">
        <property type="entry name" value="MITOCHONDRIAL GENOME MAINTENANCE PROTEIN MGM101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31404:SF0">
        <property type="entry name" value="MITOCHONDRIAL GENOME MAINTENANCE PROTEIN MGM101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06420">
        <property type="entry name" value="Mgm101p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1135">Mitochondrion nucleoid</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="8"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="29"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="42"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="96"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OAG08127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="300" mass="32295" checksum="957078EC5CDDD99A" modified="2016-09-07" version="1">MAARRGVSSLITSSCSRSTPSAYRATHRAFSSSPASGAFVNSTPRASTASTSTAAKPASTTTATKPASATSPSYSSTQRTVTPSFPAKEPPVPTARNASATEATTGQRSLTDGLSDQPAEIEGVPAIDWTRSYHGLGSVSFSPEQAEVLLAPIVQDDVEVKPDGIIYLPEIKYRRILNKAFGPGGWGLAPRGESIVTGKIVTREYGLIVQGRLVAIARGEQQYFDPDGIPTATEGCKSNALMRCCKDLGIASELWDPRFIRTFTKDNTKEIWVEHVVNKKKKKVVIRKDDVVRYPFKATQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CN21</accession>
    <name>A0A177CN21_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="21">Endoplasmic oxidoreductin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">CC84DRAFT_1162717</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 17">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">May function both as a monomer and a homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Lumenal side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the EROs family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039248.1">
        <property type="nucleotide sequence ID" value="XM_018178074.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CN21"/>
    <dbReference type="FunCoup" id="A0A177CN21">
        <property type="interactions" value="748"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CN21"/>
    <dbReference type="GeneID" id="28761560"/>
    <dbReference type="InParanoid" id="A0A177CN21"/>
    <dbReference type="OrthoDB" id="269384at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016972">
        <property type="term" value="F:thiol oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034975">
        <property type="term" value="P:protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007266">
        <property type="entry name" value="Ero1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037192">
        <property type="entry name" value="ERO1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12613:SF0">
        <property type="entry name" value="ERO1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12613">
        <property type="entry name" value="ERO1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04137">
        <property type="entry name" value="ERO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017205">
        <property type="entry name" value="ERO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110019">
        <property type="entry name" value="ERO1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 18" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 17" id="KW-0274">FAD</keyword>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 20" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="20">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008058385" evidence="20">
        <location>
            <begin position="22"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="128"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="224"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="522"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="226"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="16">
        <location>
            <position position="429"/>
        </location>
    </feature>
    <feature type="active site" evidence="16">
        <location>
            <position position="432"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="300"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="303"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="332"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="18">
        <location>
            <begin position="99"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="18">
        <location>
            <begin position="429"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR017205-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR017205-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR017205-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="OAG08883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="618" mass="69994" checksum="C47A07A682832CF3" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CNL6</accession>
    <name>A0A177CNL6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1162708</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039241.1">
        <property type="nucleotide sequence ID" value="XM_018178071.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CNL6"/>
    <dbReference type="STRING" id="1460663.A0A177CNL6"/>
    <dbReference type="GeneID" id="28761557"/>
    <dbReference type="InParanoid" id="A0A177CNL6"/>
    <dbReference type="OrthoDB" id="5345504at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046591">
        <property type="entry name" value="DUF6649"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20354">
        <property type="entry name" value="DUF6649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="200"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG08876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="226" mass="24652" checksum="3FAD032879F08E87" modified="2016-09-07" version="1">MAEVVAPGQDPDTPPTQPRRLHGKKRAADGQLESEQRLSKRFDLLNPDNGTRLYLPVASSSDAALTPGQRARQAAEPVPVPAAPKTETKRPRPPPPDDCMQVEDTPHRVYIADLDAELSDIESDEDNPIFLQDIEKHLAKIPKHVLTGPEPKPTKDNQLILYNVPSSLTVPEAQDSVRKAIVEARGRIRERQTSRSGTVEPATAPAATSATEIPPPSFDSDAMDID</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CPD1</accession>
    <name>A0A177CPD1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CC84DRAFT_1257465</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039014.1">
        <property type="nucleotide sequence ID" value="XM_018184736.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CPD1"/>
    <dbReference type="STRING" id="1460663.A0A177CPD1"/>
    <dbReference type="GeneID" id="28768222"/>
    <dbReference type="InParanoid" id="A0A177CPD1"/>
    <dbReference type="OrthoDB" id="5414787at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051430">
        <property type="entry name" value="Fungal_TF_Env_Response"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31944">
        <property type="entry name" value="HEME-RESPONSIVE ZINC FINGER TRANSCRIPTION FACTOR HAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31944:SF131">
        <property type="entry name" value="HEME-RESPONSIVE ZINC FINGER TRANSCRIPTION FACTOR HAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="8">
        <location>
            <begin position="298"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="58"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="644"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="61"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="661"/>
            <end position="671"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAG08649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="733" mass="82393" checksum="6E5CF2B9B00D08D4" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CPK4</accession>
    <name>A0A177CPK4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF1446-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1172026</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG09453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039818.1">
        <property type="nucleotide sequence ID" value="XM_018179946.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CPK4"/>
    <dbReference type="GeneID" id="28763432"/>
    <dbReference type="InParanoid" id="A0A177CPK4"/>
    <dbReference type="OrthoDB" id="10265871at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056362">
        <property type="entry name" value="AtuA-like_ferredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010839">
        <property type="entry name" value="AtuA_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47585">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47585:SF2">
        <property type="entry name" value="DUF1446 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G11420)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07287">
        <property type="entry name" value="AtuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23544">
        <property type="entry name" value="AtuA_ferredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyclic terpene utilisation N-terminal" evidence="1">
        <location>
            <begin position="16"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="domain" description="AtuA-like ferredoxin-fold" evidence="2">
        <location>
            <begin position="518"/>
            <end position="616"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG09453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="628" mass="69401" checksum="19D2FC1C32589C70" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CQV6</accession>
    <name>A0A177CQV6_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">DNA ligase</fullName>
            <ecNumber evidence="16">6.5.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">CC84DRAFT_1136897</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">DNA ligase involved in DNA non-homologous end joining (NHEJ); required for double-strand break (DSB) repair.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 16">
            <text>ATP + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m = (deoxyribonucleotide)n+m + AMP + diphosphate.</text>
            <dbReference type="EC" id="6.5.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 17">Belongs to the ATP-dependent DNA ligase family.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.1" evidence="16"/>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG09338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039703.1">
        <property type="nucleotide sequence ID" value="XM_018176119.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CQV6"/>
    <dbReference type="FunCoup" id="A0A177CQV6">
        <property type="interactions" value="576"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CQV6"/>
    <dbReference type="GeneID" id="28759605"/>
    <dbReference type="InParanoid" id="A0A177CQV6"/>
    <dbReference type="OrthoDB" id="151490at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032807">
        <property type="term" value="C:DNA ligase IV complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003910">
        <property type="term" value="F:DNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006297">
        <property type="term" value="P:nucleotide-excision repair, DNA gap filling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07903">
        <property type="entry name" value="Adenylation_DNA_ligase_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17722">
        <property type="entry name" value="BRCT_DNA_ligase_IV_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07968">
        <property type="entry name" value="OBF_DNA_ligase_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000234">
        <property type="entry name" value="DNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.30:FF:000013">
        <property type="entry name" value="DNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3260.10:FF:000008">
        <property type="entry name" value="DNA ligase 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3260.10">
        <property type="entry name" value="DNA ligase, ATP-dependent, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.30">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044125">
        <property type="entry name" value="Adenylation_DNA_ligase_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000977">
        <property type="entry name" value="DNA_ligase_ATP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012309">
        <property type="entry name" value="DNA_ligase_ATP-dep_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012310">
        <property type="entry name" value="DNA_ligase_ATP-dep_cent"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016059">
        <property type="entry name" value="DNA_ligase_ATP-dep_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012308">
        <property type="entry name" value="DNA_ligase_ATP-dep_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036599">
        <property type="entry name" value="DNA_ligase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029710">
        <property type="entry name" value="LIG4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00574">
        <property type="entry name" value="dnl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45997">
        <property type="entry name" value="DNA LIGASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45997:SF1">
        <property type="entry name" value="DNA LIGASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16589">
        <property type="entry name" value="BRCT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04679">
        <property type="entry name" value="DNA_ligase_A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01068">
        <property type="entry name" value="DNA_ligase_A_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04675">
        <property type="entry name" value="DNA_ligase_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117018">
        <property type="entry name" value="ATP-dependent DNA ligase DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56091">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00697">
        <property type="entry name" value="DNA_LIGASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00333">
        <property type="entry name" value="DNA_LIGASE_A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50160">
        <property type="entry name" value="DNA_LIGASE_A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 16" id="KW-0227">DNA damage</keyword>
    <keyword evidence="11 16" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="12 16" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4 16 21" id="KW-0436">Ligase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ATP-dependent DNA ligase family profile" evidence="19">
        <location>
            <begin position="432"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="20">
        <location>
            <begin position="727"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="59"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="18">
        <location>
            <begin position="60"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00034003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00043870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU000617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU004196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="OAG09338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="991" mass="113205" checksum="3083AC6F0C52C296" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CR37</accession>
    <name>A0A177CR37_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_436536</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG09428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039793.1">
        <property type="nucleotide sequence ID" value="XM_018186263.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CR37"/>
    <dbReference type="GeneID" id="28769749"/>
    <dbReference type="InParanoid" id="A0A177CR37"/>
    <dbReference type="OrthoDB" id="10265591at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG09428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="273" mass="29562" checksum="C795D5F2A0CFF8D4" modified="2016-09-07" version="1">MQDALAAGDLIDYADDAIAAMGSSGSTTPYATQETPIAAPSTMDDSFQVQYSRTNGIIESSSLEGAIAQLAGPSTWSQKRECGYDAAMRAVQADPLEVTDLYFPLGSWDDATYVRSDRSSSEDTVAFAGAPSSMTSQLGSIPVDSRRNSNLTVPGQNSAWSPLDTGACFGPMQWTEHMSSIEHESFANPSHVYGLPMVSLKMTPSDPYVMTNEMEHLLYQRMGSLYGDPGTYSKVCSQNFGSTLTEWYREDVRQLAHCISDCHVGAQAYGKYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CRB1</accession>
    <name>A0A177CRB1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Poly A polymerase C-terminal region-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CC84DRAFT_1111963</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the TTI2 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040420.1">
        <property type="nucleotide sequence ID" value="XM_018175305.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CRB1"/>
    <dbReference type="STRING" id="1460663.A0A177CRB1"/>
    <dbReference type="GeneID" id="28758791"/>
    <dbReference type="InParanoid" id="A0A177CRB1"/>
    <dbReference type="OrthoDB" id="445712at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110078">
        <property type="term" value="C:TTT Hsp90 cochaperone complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052929">
        <property type="term" value="F:ATP:3'-cytidine-cytidine-tRNA adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052927">
        <property type="term" value="F:CC tRNA cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001680">
        <property type="term" value="P:tRNA 3'-terminal CCA addition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05398">
        <property type="entry name" value="NT_ClassII-CCAase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.460.10:FF:000019">
        <property type="entry name" value="tRNA nucleotidyltransferase cca2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3090.10">
        <property type="entry name" value="cca-adding enzyme, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002646">
        <property type="entry name" value="PolA_pol_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032828">
        <property type="entry name" value="PolyA_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018870">
        <property type="entry name" value="Tti2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13734:SF5">
        <property type="entry name" value="CCA TRNA NUCLEOTIDYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13734">
        <property type="entry name" value="TRNA-NUCLEOTIDYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01743">
        <property type="entry name" value="PolyA_pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12627">
        <property type="entry name" value="PolyA_pol_RNAbd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10521">
        <property type="entry name" value="Tti2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81891">
        <property type="entry name" value="Poly A polymerase C-terminal region-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Poly A polymerase head" evidence="8">
        <location>
            <begin position="145"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA nucleotidyltransferase/poly(A) polymerase RNA and SrmB- binding" evidence="9">
        <location>
            <begin position="323"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="56"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAG10055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="976" mass="110343" checksum="F4692860862DF443" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CRI6</accession>
    <name>A0A177CRI6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ATP-NAD kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CC84DRAFT_1160684</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NAD kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG09552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039917.1">
        <property type="nucleotide sequence ID" value="XM_018177556.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CRI6"/>
    <dbReference type="FunCoup" id="A0A177CRI6">
        <property type="interactions" value="572"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CRI6"/>
    <dbReference type="GeneID" id="28761042"/>
    <dbReference type="InParanoid" id="A0A177CRI6"/>
    <dbReference type="OrthoDB" id="24581at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003951">
        <property type="term" value="F:NAD+ kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019674">
        <property type="term" value="P:NAD+ metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006741">
        <property type="term" value="P:NADP+ biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.30:FF:000005">
        <property type="entry name" value="NAD+ kinase Utr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10330:FF:000025">
        <property type="entry name" value="NAD+ kinase Utr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.30">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00361">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017437">
        <property type="entry name" value="ATP-NAD_kinase_PpnK-typ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002504">
        <property type="entry name" value="NADK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20275">
        <property type="entry name" value="NAD KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20275:SF0">
        <property type="entry name" value="NAD KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01513">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20143">
        <property type="entry name" value="NAD_kinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="NAD kinase/diacylglycerol kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="38"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="589"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="41"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="116"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="596"/>
            <end position="621"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAG09552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="648" mass="71814" checksum="0F3E5C79FD6B6C6B" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CSL0</accession>
    <name>A0A177CSL0_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CC84DRAFT_1237333</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040889.1">
        <property type="nucleotide sequence ID" value="XM_018183894.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CSL0"/>
    <dbReference type="STRING" id="1460663.A0A177CSL0"/>
    <dbReference type="GeneID" id="28767380"/>
    <dbReference type="InParanoid" id="A0A177CSL0"/>
    <dbReference type="OrthoDB" id="2269373at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF85">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="9"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="77"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAG10524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="594" mass="68069" checksum="03D325BD7646257A" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CSW0</accession>
    <name>A0A177CSW0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_483201</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040751.1">
        <property type="nucleotide sequence ID" value="XM_018186453.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CSW0"/>
    <dbReference type="GeneID" id="28769939"/>
    <dbReference type="InParanoid" id="A0A177CSW0"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="163"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG10386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="193" mass="21755" checksum="A84B8FA19A1512A8" modified="2016-09-07" version="1">MCAPLLEECGEEGRDWGTTRHARHRRHDNKQNSKSRIPTRAVVGCRSVAQLRRPQKRLCYPQAHPRSWDVETHGPAGIVRARIRANEVLTYRHKSATPRCGRARLRPMPSQSPREITSKVAHVEWVVSSILRTFNTPLTAQPYRVAVQGRTSLEASHDVLEAQRSNPRHAVEPSHRISATPIQTPQHAGNACP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CU70</accession>
    <name>A0A177CU70_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CC84DRAFT_1172756</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040692.1">
        <property type="nucleotide sequence ID" value="XM_018179998.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CU70"/>
    <dbReference type="STRING" id="1460663.A0A177CU70"/>
    <dbReference type="GeneID" id="28763484"/>
    <dbReference type="InParanoid" id="A0A177CU70"/>
    <dbReference type="OrthoDB" id="5418899at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF9">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="6"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="212"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="363"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="233"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="363"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAG10327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="743" mass="83055" checksum="557935AC92AA29F0" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CUH3</accession>
    <name>A0A177CUH3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">CIA30-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CC84DRAFT_1112726</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CIA30 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040802.1">
        <property type="nucleotide sequence ID" value="XM_018175327.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CUH3"/>
    <dbReference type="STRING" id="1460663.A0A177CUH3"/>
    <dbReference type="GeneID" id="28758813"/>
    <dbReference type="InParanoid" id="A0A177CUH3"/>
    <dbReference type="OrthoDB" id="42561at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010257">
        <property type="term" value="P:NADH dehydrogenase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013857">
        <property type="entry name" value="NADH-UbQ_OxRdtase-assoc_prot30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039131">
        <property type="entry name" value="NDUFAF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13194">
        <property type="entry name" value="COMPLEX I INTERMEDIATE-ASSOCIATED PROTEIN 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13194:SF18">
        <property type="entry name" value="COMPLEX I INTERMEDIATE-ASSOCIATED PROTEIN 30, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08547">
        <property type="entry name" value="CIA30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:ubiquinone oxidoreductase intermediate-associated protein 30" evidence="6">
        <location>
            <begin position="45"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="244"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="250"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAG10437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="265" mass="29806" checksum="457F389F0057E31B" modified="2016-09-07" version="1">MRPTARCLTPGFMKRSLDEFKRLSNRALKLEGLSSPTKPYPLIIFDSQDAIARCKRMSDKDIGGFSAANLDFHAATANEPAHARFHGTISTELPRDQPHVQRTGYAGWRTLDRGFTIFGKSVWDVDSYAYLAIQFKSDGRKYFVNVQTESIVPTDIHQHRLYSKTPGEWETILIKWNEFVRTNHGQVVEPQREMLTQKVRTVGNALIDRIPGPYDLSISKVWATNATSDDDILATVTGAITGLPSQHGFKKVETPKQEPLGDRSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CUL9</accession>
    <name>A0A177CUL9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RPEL repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CC84DRAFT_1161488</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040935.1">
        <property type="nucleotide sequence ID" value="XM_018177753.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CUL9"/>
    <dbReference type="STRING" id="1460663.A0A177CUL9"/>
    <dbReference type="GeneID" id="28761239"/>
    <dbReference type="InParanoid" id="A0A177CUL9"/>
    <dbReference type="OrthoDB" id="197676at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043451">
        <property type="entry name" value="Myocardin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004018">
        <property type="entry name" value="RPEL_repeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22793:SF12">
        <property type="entry name" value="MYOCARDIN-RELATED TRANSCRIPTION FACTOR, ISOFORM H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22793">
        <property type="entry name" value="MYOCARDIN-RELATED TRANSCRIPTION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02755">
        <property type="entry name" value="RPEL"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00707">
        <property type="entry name" value="RPEL"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51073">
        <property type="entry name" value="RPEL"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="RPEL" evidence="4">
        <location>
            <begin position="21"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="repeat" description="RPEL" evidence="4">
        <location>
            <begin position="65"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="repeat" description="RPEL" evidence="4">
        <location>
            <begin position="109"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="66"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="16"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="66"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="98"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAG10570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="140" mass="15975" checksum="0F6445138A93F46F" modified="2016-09-07" version="1">MTDAAIDETPISPIRSLERRDSLEKHLQHRPDPQDLKNRHILLDTNTAPALQAKALELERQRATDNLKKGLEHRPEREALVERNILPDSNAAPALQGHQRELEKNMRADSLEKGLQHRPSPEELVKKGILEADENPLKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CVC8</accession>
    <name>A0A177CVC8_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Wax synthase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CC84DRAFT_1173178</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041207.1">
        <property type="nucleotide sequence ID" value="XM_018180013.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CVC8"/>
    <dbReference type="STRING" id="1460663.A0A177CVC8"/>
    <dbReference type="GeneID" id="28763499"/>
    <dbReference type="InParanoid" id="A0A177CVC8"/>
    <dbReference type="OrthoDB" id="1077582at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032805">
        <property type="entry name" value="Wax_synthase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13813">
        <property type="entry name" value="MBOAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="38"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="322"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="349"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="Wax synthase" evidence="6">
        <location>
            <begin position="271"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAG10842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="404" mass="45983" checksum="AF590E8531BD4776" modified="2016-09-07" version="1">MALQDEWTLALAAQHIAWAFSFCATCLAVGCVPDLGKWTGFIVLLAPASGALYTSPNLSPNKYFNDTYSRFVIILFSYMVALCFMPGSRVSVTKDKTKELDTSWRAGWKRAYNARGIGLAWENPYLWPEQKSTIVFAKPSSETYKDKPVEAPASRHALATRSKWSAVLIHCVYLLINYVAMKLYFEYRVSATIGGFVRSDLSPEKEGILRRLFLQSQPEGLVTSPVTVRELQIRLLLAANKFIPDVLSLSAFHDLLAIIFIATGIDQPWEWPPLFGPVSEAYTMRRFWANFWHRLVYKSFNFHASTFTKALRIPQGTSFSRILNNCLVFVLSAIMHATVTWLYGGKCAWGRGTMVFWCIQPLSFVLEGLVQYNWKQYRKSKLWWMNASVLAAFERVAGILENRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CVD3</accession>
    <name>A0A177CVD3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein-lysine N-methyltransferase EFM5</fullName>
            <ecNumber evidence="5">2.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Elongation factor methyltransferase 5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">EFM5</name>
        <name evidence="6" type="ORF">CC84DRAFT_1158782</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">S-adenosyl-L-methionine-dependent protein-lysine N-methyltransferase that trimethylates elongation factor 1-alpha at 'Lys-79'.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM5 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="5"/>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG11181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041546.1">
        <property type="nucleotide sequence ID" value="XM_018177068.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CVD3"/>
    <dbReference type="FunCoup" id="A0A177CVD3">
        <property type="interactions" value="298"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CVD3"/>
    <dbReference type="GeneID" id="28760554"/>
    <dbReference type="InParanoid" id="A0A177CVD3"/>
    <dbReference type="OrthoDB" id="206354at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03187">
        <property type="entry name" value="Methyltr_EFM5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019369">
        <property type="entry name" value="Efm5/EEF1AKMT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041370">
        <property type="entry name" value="Mlase_EEF1AKMT1/ZCCHC4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13200">
        <property type="entry name" value="EEF1A LYSINE METHYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13200:SF0">
        <property type="entry name" value="EEF1A LYSINE METHYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10237">
        <property type="entry name" value="N6-adenineMlase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAG11181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="241" mass="27073" checksum="2FDC783B2453A544" modified="2016-09-07" version="1">MADSDDDGPIQLSSGALDALKEFYGERDARAKQFEDLKTQAEDEFAGKLSMEAFTEDWNASQFWYSDETATTLARQLLDGATDDTRIAVVSAPSTFIQLKNLLTSAAYTAKPHLTLLEYDTRFNVFKEFVPYDFEAPLKLPAELKGSFDAIIVDPPFLSEDCQTKAALTVRWLSRSWIPGSAGVKLIACTGERMESLITKLYAKVGVRTTDFEVRHAKGLSNEFRCYANFECGEWKWAKQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CW37</accession>
    <name>A0A177CW37_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Glyceraldehyde-3-phosphate dehydrogenase</fullName>
            <ecNumber evidence="12">1.2.1.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CC84DRAFT_1082743</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>D-glyceraldehyde 3-phosphate + phosphate + NAD(+) = (2R)-3-phospho-glyceroyl phosphate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10300"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57604"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="1.2.1.12"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 12">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 1/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 12">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.12" evidence="12"/>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG11017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041382.1">
        <property type="nucleotide sequence ID" value="XM_018173993.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CW37"/>
    <dbReference type="FunCoup" id="A0A177CW37">
        <property type="interactions" value="1115"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CW37"/>
    <dbReference type="GeneID" id="28757479"/>
    <dbReference type="InParanoid" id="A0A177CW37"/>
    <dbReference type="OrthoDB" id="1152826at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00184"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004365">
        <property type="term" value="F:glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd18126">
        <property type="entry name" value="GAPDH_I_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05214">
        <property type="entry name" value="GAPDH_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.10:FF:000001">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000020">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020831">
        <property type="entry name" value="GlycerAld/Erythrose_P_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020830">
        <property type="entry name" value="GlycerAld_3-P_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020829">
        <property type="entry name" value="GlycerAld_3-P_DH_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020828">
        <property type="entry name" value="GlycerAld_3-P_DH_NAD(P)-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006424">
        <property type="entry name" value="Glyceraldehyde-3-P_DH_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01534">
        <property type="entry name" value="GAPDH-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10836">
        <property type="entry name" value="GLYCERALDEHYDE 3-PHOSPHATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10836:SF76">
        <property type="entry name" value="GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02800">
        <property type="entry name" value="Gp_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00044">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000149">
        <property type="entry name" value="GAP_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00078">
        <property type="entry name" value="G3PDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00846">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00071">
        <property type="entry name" value="GAPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="5 9 12" id="KW-0520">NAD</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding" evidence="13">
        <location>
            <begin position="3"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="7">
        <location>
            <position position="151"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="12"/>
            <end position="13"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="150"/>
            <end position="152"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="210"/>
            <end position="211"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="315"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="site" description="Activates thiol group during catalysis" evidence="10">
        <location>
            <position position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OAG11017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="337" mass="36510" checksum="7124E6925B13D691" modified="2016-09-07" version="1">MVVKVGINGFGRIGRIVFRNAVEHNDVDIVAVNDPFIEPHYAAYMLRYDSTHGQFKGTIEVDGNNLKVNGKTVKFYTEKDPAQIPWSETGAYYVVESTGVFTTKDKAGLHLKGGAKKVVISAPSADAPMFVMGVNNETYKSDIDVLSNASCTTNCLAPLAKVIHDKFTIIEGLMTTVHSYTATQKVVDGPSAKDWRGGRTAAQNIIPSSTGAAKAVGKVIPDLNGKLTGMSMRVPTSNVSVVDLTVRIEKGATYDEIKEAIKEASEGSLKGILGYTEDDIVSTDLNGDNRSSIFDAKAGISLNKNFVKLVSWYDNEWGYSRRVLDLLVYIAKIDGNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CW60</accession>
    <name>A0A177CW60_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1223859</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG11132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041497.1">
        <property type="nucleotide sequence ID" value="XM_018183526.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CW60"/>
    <dbReference type="GeneID" id="28767012"/>
    <dbReference type="InParanoid" id="A0A177CW60"/>
    <dbReference type="OrthoDB" id="3862662at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="156"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG11132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="248" mass="27856" checksum="BF2B4163769FFC7B" modified="2016-09-07" version="1">MPAKPVEIRNQRPVCSQCASSGASCRYPPTNKRGIPSGYIALVEQRLLESEIVIFELLSTLYNYNPTVRQHRLSFDERHSLGEWSKQQSKAKKVEEWTNFPLGTDEQRQAWWLKKQDSIGRCEGSDAGNVDSPATNAFLGVLPDASPISAGFEETQQQQQQQQQQKSMDTPLPLASTVSETTTVLQHPWTSQMDSQSGSDADNSFRSSSMSGPPMMDERPQYATVNNSVNHASPEARHSTSDRWRKYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CWE6</accession>
    <name>A0A177CWE6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1225650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG11884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042249.1">
        <property type="nucleotide sequence ID" value="XM_018183573.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CWE6"/>
    <dbReference type="GeneID" id="28767059"/>
    <dbReference type="InParanoid" id="A0A177CWE6"/>
    <dbReference type="OrthoDB" id="10625116at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG11884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="212" mass="22088" checksum="26A041D5D162E283" modified="2016-09-07" version="1">MATHMAPGTQAAAASASTLDAASIDSRRRANGAGCIASAYLRRTAGHGSPADGARPVTVLWWPLSTEPSWALCLAVPGRGPRRGEGASGRCWRQNAHNAAMDHAVGCAVSSPTQPPARSAWVTTPPSNRLRQPLQSRASSVRPAEDSSLPASHLYSSALSLRAGPLAVPADMTAYATVGIPTRTAQMASLHMDLINTGRMSRTPPPFRCAST</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CX85</accession>
    <name>A0A177CX85_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1159134</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG11658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042023.1">
        <property type="nucleotide sequence ID" value="XM_018177146.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CX85"/>
    <dbReference type="STRING" id="1460663.A0A177CX85"/>
    <dbReference type="GeneID" id="28760632"/>
    <dbReference type="InParanoid" id="A0A177CX85"/>
    <dbReference type="OrthoDB" id="1263307at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052897">
        <property type="entry name" value="Sec-Metab_Biosynth_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37017:SF13">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37017">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="6"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG11658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="240" mass="26096" checksum="2CC1DB964A59BCD9" modified="2016-09-07" version="1">MTNPSIVIVPGSFTAKGIYQDLVDRLRAKGFPALAINLLSSQKRLGLEPATMKDDAKRVRDVAEALLAQGKEVVVLGHSYGGVPMTEGLAGVPVKRIIYLAAIAPKVGQSHVESMPGPLIDALLDSSVGGYMHSDPAQLASGLGIDSWEFAYECAQKLPHHSVAAFTEKTTQAAYETVPVSYMFTEKDVIVTQEHQESYIKMMEEVTGSKIDVIRKPWGHCPNWSHPDELVDVLVKVAEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CYR8</accession>
    <name>A0A177CYR8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1080602</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042402.1">
        <property type="nucleotide sequence ID" value="XM_018173898.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CYR8"/>
    <dbReference type="GeneID" id="28757384"/>
    <dbReference type="InParanoid" id="A0A177CYR8"/>
    <dbReference type="OrthoDB" id="5409477at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG12037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="229" mass="25876" checksum="3A95C7C5A604E461" modified="2016-09-07" version="1" fragment="single">EMDAAPNCAICNAPAYPECPCESERLQIAVKQAENRAMEEKLTEIRDWVISHARQHILNQFERLTSTRKAQHSAYLATLPNYTIYMQYSGHPPIHPIYIENLQRQIAEAHAELKRGIDADWRASVLRYPDVLDYFYGLVQLKLPDERSPRVVEPPFAAAGYADRGFAGQIAKEKKKKRRDSSLAPVERGRHRDEPPMHAVLGRVRGPPAAPTPPIGGGYPRPPPMYPGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CYV0</accession>
    <name>A0A177CYV0_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">2, 3 cyclic phosphodiesterase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1068698</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042686.1">
        <property type="nucleotide sequence ID" value="XM_018173649.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CYV0"/>
    <dbReference type="STRING" id="1460663.A0A177CYV0"/>
    <dbReference type="GeneID" id="28757135"/>
    <dbReference type="InParanoid" id="A0A177CYV0"/>
    <dbReference type="OrthoDB" id="5364416at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1140.10">
        <property type="entry name" value="Cyclic phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009097">
        <property type="entry name" value="Cyclic_Pdiesterase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13563">
        <property type="entry name" value="2_5_RNA_ligase2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55144">
        <property type="entry name" value="LigT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG12321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="176" mass="20147" checksum="F10B1AB6174E7DE7" modified="2016-09-07" version="1" fragment="single">RTSPHRAIAAHAPNTGIDEQHVYVLTLALSPSIAVPLDQMRDEYFPRHLNRTPAHITLFHALPHSQLDAIDADLTRLTSRTRPYHISTGTPFRLKRGVAVLLGTGEECSQALREELRSKWAAFLSQQDSRSRGWQPHWTVQNKVEEEKKVVSAYNTLRRILYEETHYGKALGFDLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CZD6</accession>
    <name>A0A177CZD6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phosphoglycerate mutase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1211980</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042783.1">
        <property type="nucleotide sequence ID" value="XM_018182415.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CZD6"/>
    <dbReference type="GeneID" id="28765901"/>
    <dbReference type="InParanoid" id="A0A177CZD6"/>
    <dbReference type="OrthoDB" id="496981at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001345">
        <property type="entry name" value="PG/BPGM_mutase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050275">
        <property type="entry name" value="PGM_Phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100">
        <property type="entry name" value="BROAD-SPECIFICITY PHOSPHATASE YOR283W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100:SF54">
        <property type="entry name" value="PHOSPHATASE SPAC5H10.03-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00175">
        <property type="entry name" value="PG_MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG12418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="261" mass="29731" checksum="86027A922D17D506" modified="2016-09-07" version="1">MPPKKISIVRHGQGFHNLTHNYDLRDPLLTPLGHEQCAQLSATYPNHDTVDLIIASPIRRTIQTAAFSFGPALARADVPFLLDPKLQELGSHNADRGLDPEDLKTWLTETEKEGEKKFKFDWEKIDVSGVEEGWNSKKGYYAYEANAIYQRAADMRASLYQRNEDHIVLVSHGAIAHFLTEDWQIHDPMLGTNWSNCEIREYVFSGNSKDGDAHLVEIEESKARRPPYEGPVWEAPWKGVRSGDKDEHVVEEIKEVEAEIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CZT4</accession>
    <name>A0A177CZT4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Integral membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1077377</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042725.1">
        <property type="nucleotide sequence ID" value="XM_018173751.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CZT4"/>
    <dbReference type="STRING" id="1460663.A0A177CZT4"/>
    <dbReference type="GeneID" id="28757237"/>
    <dbReference type="InParanoid" id="A0A177CZT4"/>
    <dbReference type="OrthoDB" id="444631at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF92">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="165"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="199"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="240"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG12360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="285" mass="31840" checksum="3FAA55EE8D8F1AC3" modified="2016-09-07" version="1">MGNDYFLVAGVPILLTGFALLQSVIYQLYWTEESLTDNTTAWSRHTDTSRRLVAAIELIWVAIYCVKFCYLAQFKFYKPPYAYVDAALTRHYWAVVGLCSVGFLFTLVQPIVLCTTRGKCRYIDGLDTRSWEIAVTVIDIVTDVLVMSIPMLLVHMANHVRPYTIANFVFKSLSIFSVVVAATRLALQYDSTVGRIRYVSVTFLLVIEATIALIMVSISGYRVVFLDFLSEWERRKTTHSTRLTVRQGRHRTATAAGGGGGEADNAKPSQPRAGSLSDLPILSTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177D0I5</accession>
    <name>A0A177D0I5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1212428</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018043316.1">
        <property type="nucleotide sequence ID" value="XM_018182454.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177D0I5"/>
    <dbReference type="GeneID" id="28765940"/>
    <dbReference type="InParanoid" id="A0A177D0I5"/>
    <dbReference type="OrthoDB" id="3942467at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="245"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG12951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="262" mass="28885" checksum="0292411BAF8FCF9B" modified="2016-09-07" version="1">MDPSRNLALHNAKLQIILSNWQTSQSAPSPESESEIDMPPPPAYHTVADPTESLPEMMHRLYDAEEEEVKETEMPEININATTQIRGHGNIISIAQMDSMRVANLLAILIHGGIPPQTQTNVQGREENAPAPSMTDRPAQERRELPKINININCGATVIGDRNIVGPGLGDIARHMQLAQQRQQAQQQQQQQQQQQQNQAKLDSRTAQPPRPVFGFPAPTQAPLVTPPMSRSSSFGSEGSGGVKRKAEEGRTEMPVKKEKCM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177D0Z3</accession>
    <name>A0A177D0Z3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Bacteriophage T5 Orf172 DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1171689</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG13078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018043443.1">
        <property type="nucleotide sequence ID" value="XM_018179923.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177D0Z3"/>
    <dbReference type="STRING" id="1460663.A0A177D0Z3"/>
    <dbReference type="GeneID" id="28763409"/>
    <dbReference type="InParanoid" id="A0A177D0Z3"/>
    <dbReference type="OrthoDB" id="3511049at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053006">
        <property type="entry name" value="Meiosis_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018306">
        <property type="entry name" value="Phage_T5_Orf172_DNA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28094">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 113 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28094:SF1">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 113 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10544">
        <property type="entry name" value="T5orf172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00974">
        <property type="entry name" value="T5orf172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bacteriophage T5 Orf172 DNA-binding" evidence="2">
        <location>
            <begin position="449"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="204"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="273"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="310"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="365"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG13078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="624" mass="69615" checksum="35878F8D9D8169C8" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BU52</accession>
    <name>A0A177BU52_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CC84DRAFT_1050719</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RBT5 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441564">
        <property type="protein sequence ID" value="OAF98784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029150.1">
        <property type="nucleotide sequence ID" value="XM_018173470.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BU52"/>
    <dbReference type="GeneID" id="28756956"/>
    <dbReference type="InParanoid" id="A0A177BU52"/>
    <dbReference type="OrthoDB" id="3932980at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008427">
        <property type="entry name" value="Extracellular_membr_CFEM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05730">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="domain" description="CFEM" evidence="9">
        <location>
            <begin position="37"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAF98784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="140" mass="15418" checksum="D978EEAADF82EC8B" modified="2016-09-07" version="1" fragment="single">ALTAAQRTYNVTSALAPGQLEKYKCLTTERWLKDFGIPECMHECTREANSKDGCAYDDFACHNINYQVYSDIIEPCAFPPQLGGSGTCTLEELGAIRPKVADAGNFFNATLYAAYADKHCEVRLSILKTLKIIADEATII</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BUM1</accession>
    <name>A0A177BUM1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_1170025</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KV441565">
        <property type="protein sequence ID" value="OAF98670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029036.1">
        <property type="nucleotide sequence ID" value="XM_018179818.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BUM1"/>
    <dbReference type="GeneID" id="28763304"/>
    <dbReference type="InParanoid" id="A0A177BUM1"/>
    <dbReference type="OrthoDB" id="2365600at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11375">
        <property type="entry name" value="Peptidase_M54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012962">
        <property type="entry name" value="Pept_M54_archaemetzincn"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15910">
        <property type="entry name" value="ARCHAEMETZINCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15910:SF1">
        <property type="entry name" value="ARCHAEMETZINCIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07998">
        <property type="entry name" value="Peptidase_M54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="25"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="128"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAF98670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="482" mass="52900" checksum="520200FC4AC667AD" modified="2016-09-07" version="1">MMTKRPSCSHSTLLFEPSPFAELAGFERPDQRTRIAATSKSGRAPPAVRNNSQTTASLSKEAQKESQTYPGPLVLPHDALNYDPDGDEPAQSFRSWLHEKARNKVTPERRTLYVGAPPTIDENVSFMKGWTTPNPAPDAAPSKTPSKKPRTEREPQSTTTNALQSPGVEETIAYLRAFYHGFDVAPLPIDLRWTSWENHGKGAKYRPVDTVRGIPTYIALSYNGVATRIRARRAPDGAFAAQLNLDDILDAAIAMLPADAYAIVLLVDHDIYESPDDDFCAGRAYGGSRVSVVQSARYNPLLDATVGITQDHAWPASHCKSYIDSLCAVEEMEAKPATATQTRLSKSGPMRAAVNAVSKLVVSDSNADLEALWSSRVVRTVSHELGHCICLAHCFYYACIMQSTASLLEDIRQSPFLCPVCDSKVSHTVAVELQGGTEEDKKRWVRDRYSALKSFCEGGDRLQTTLWAGFHGWLGEVLGDKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BUX9</accession>
    <name>A0A177BUX9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DEAD/DEAH-box helicase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1238638</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441576">
        <property type="protein sequence ID" value="OAF98468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018028834.1">
        <property type="nucleotide sequence ID" value="XM_018183954.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BUX9"/>
    <dbReference type="GeneID" id="28767440"/>
    <dbReference type="InParanoid" id="A0A177BUX9"/>
    <dbReference type="OrthoDB" id="3925403at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEAD/DEAH-box helicase" evidence="1">
        <location>
            <begin position="5"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAF98468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="49" mass="5283" checksum="6E2BE44666F88A8B" modified="2016-09-07" version="1" fragment="single">GQTLLIIVLPTGGGKSLLFIVPAFILGARVTILMVPFQALIEDHVQRIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BVD6</accession>
    <name>A0A177BVD6_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ATP-dependent RNA helicase DED1</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">ATP-dependent RNA helicase ded1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">CC84DRAFT_1181872</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">ATP-binding RNA helicase involved in translation initiation. Remodels RNA in response to ADP and ATP concentrations by facilitating disruption, but also formation of RNA duplexes.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 22">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the DEAD box helicase family. DDX3/DED1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="KV441564">
        <property type="protein sequence ID" value="OAF98691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029057.1">
        <property type="nucleotide sequence ID" value="XM_018180577.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BVD6"/>
    <dbReference type="FunCoup" id="A0A177BVD6">
        <property type="interactions" value="1258"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177BVD6"/>
    <dbReference type="GeneID" id="28764063"/>
    <dbReference type="InParanoid" id="A0A177BVD6"/>
    <dbReference type="OrthoDB" id="196131at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002183">
        <property type="term" value="P:cytoplasmic translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990625">
        <property type="term" value="P:negative regulation of cytoplasmic translational initiation in response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031047">
        <property type="term" value="P:regulatory ncRNA-mediated gene silencing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000160">
        <property type="entry name" value="ATP-dependent RNA helicase DDX3X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000008">
        <property type="entry name" value="ATP-dependent RNA helicase RhlB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 15" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="19">
        <location>
            <begin position="206"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="17">
        <location>
            <begin position="237"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="18">
        <location>
            <begin position="441"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="604"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="659"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="14">
        <location>
            <begin position="206"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="73"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="16">
        <location>
            <begin position="135"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="16">
        <location>
            <begin position="605"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="16">
        <location>
            <begin position="669"/>
            <end position="697"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="OAF98691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="697" mass="73729" checksum="25B00DF6FF284BC9" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BW30</accession>
    <name>A0A177BW30_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_374202</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441561">
        <property type="protein sequence ID" value="OAF99622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029988.1">
        <property type="nucleotide sequence ID" value="XM_018185956.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BW30"/>
    <dbReference type="GeneID" id="28769442"/>
    <dbReference type="InParanoid" id="A0A177BW30"/>
    <dbReference type="OrthoDB" id="194139at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAF99622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="123" mass="13751" checksum="D2E4F3463FAFE0A6" modified="2016-09-07" version="1">MSNNSNESLDRLNITLSTPVQLRGSHGSRRIWPLVLLLILIHLSTVLYTLPLNRVIELRLCQTHYSIPNPEEKACKIDEVQRQLAWIQGVMETMLVACGTCTLLGWWNVTGSRLTLVVVAASG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BW38</accession>
    <name>A0A177BW38_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">PEBP-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1046155</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441561">
        <property type="protein sequence ID" value="OAF99632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029998.1">
        <property type="nucleotide sequence ID" value="XM_018173416.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BW38"/>
    <dbReference type="STRING" id="1460663.A0A177BW38"/>
    <dbReference type="GeneID" id="28756902"/>
    <dbReference type="InParanoid" id="A0A177BW38"/>
    <dbReference type="OrthoDB" id="2506647at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030414">
        <property type="term" value="F:peptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030162">
        <property type="term" value="P:regulation of proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046578">
        <property type="term" value="P:regulation of Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00866">
        <property type="entry name" value="PEBP_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.280.10">
        <property type="entry name" value="PEBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008914">
        <property type="entry name" value="PEBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036610">
        <property type="entry name" value="PEBP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035810">
        <property type="entry name" value="PEBP_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11362:SF148">
        <property type="entry name" value="CARBOXYPEPTIDASE Y INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11362">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01161">
        <property type="entry name" value="PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49777">
        <property type="entry name" value="PEBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAF99632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="228" mass="23918" checksum="55CA2D94ED579E0A" modified="2016-09-07" version="1" fragment="single">ALAGVASATVAPGFPLKANTDLNVTWADNNVNPPGELLSLADTALAPSQISAPVWTPGGHAILMLVDLDVPRNNTRVQLLHWLTTNVTMPSTDTQTLKLEDAKKDLAPYLRPSPPLGDIPHKYTLLLFAQPENFTVPARFKSLLQTRVGWDTAAFVNATGLGAALGADWIRVQNTGNETMTNATASATPTASSSPTSTPTNYAGMAGVVEPRAWVGAVVVAGLMAVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BW75</accession>
    <name>A0A177BW75_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1181924</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441564">
        <property type="protein sequence ID" value="OAF98767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029133.1">
        <property type="nucleotide sequence ID" value="XM_018180580.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BW75"/>
    <dbReference type="FunCoup" id="A0A177BW75">
        <property type="interactions" value="241"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177BW75"/>
    <dbReference type="GeneID" id="28764066"/>
    <dbReference type="InParanoid" id="A0A177BW75"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF154">
        <property type="entry name" value="OXIDOREDUCTASE, SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_2G04560)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAF98767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="325" mass="35967" checksum="1016FD855177C078" modified="2016-09-07" version="1">MKNIQARADFDPVKEVPSLEGKVLFITGGTAGIGAETARTLAPHGPSHIYITGRNRKAADTLIGDIQKSYASVGMTFIEVDFTSLSSVKDNVQKGFKHERLDVLMCTAGIMASPPVLSKDGYETPTDHETPEIQFATNHLAHAMLIDVLLPTLLRTARTPASDVRILSTTSMGYGFHPGNGISFAELDSRSSMPRFMLGGWVRYGHSKLANILYPAELARRYPEITSLSIHPGVVATDLMYKQDWQTRWFIHITCWLQGLKYLTPHQGCWNQVYCAAVAKKEELVNGGFYYPVGLHAPDKLDKAATDANLAGRLWEWTQGVLQKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BWV4</accession>
    <name>A0A177BWV4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_413757</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441563">
        <property type="protein sequence ID" value="OAF98987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029353.1">
        <property type="nucleotide sequence ID" value="XM_018186109.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BWV4"/>
    <dbReference type="GeneID" id="28769595"/>
    <dbReference type="InParanoid" id="A0A177BWV4"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAF98987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="90" mass="9530" checksum="9051FCF81BFB895E" modified="2016-09-07" version="1">MLVCGQMWCCATLECQCCIGEAGCPDACVISSPPAGSAVVDTALERKQGQPIAAGSDDRGRLEHLGQLKLVDNTTSDSIIRHSKKSHIVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BX53</accession>
    <name>A0A177BX53_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1169410</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441562">
        <property type="protein sequence ID" value="OAF99271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029637.1">
        <property type="nucleotide sequence ID" value="XM_018179655.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BX53"/>
    <dbReference type="GeneID" id="28763141"/>
    <dbReference type="InParanoid" id="A0A177BX53"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAF99271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="251" mass="28074" checksum="13D388A7C1D1952B" modified="2016-09-07" version="1">MRSHDESEIHRGEAGGVEPSLTILCGSPSIVQPENVTMASVSDLHQPLRSTTCTPATRHVRTVRESDCGPFLIIVYGNCTFRISRHGHQFSSRDTGAAFTAGREFLPCYTSCRMFCVPKGVNGCHRASQVSELTLADRQYAVVAKPQQNAQREPSRLQPRLFPIQARSRAEFFQCSLKVASVARLFPGRTLNPFPRRVIRYPRCGGATHHQEIRTLPYKTFAQGQTLGQTLVSRLGRKRGNQWRLVSALMH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BX63</accession>
    <name>A0A177BX63_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1263807</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441560">
        <property type="protein sequence ID" value="OAG00094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030459.1">
        <property type="nucleotide sequence ID" value="XM_018185259.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BX63"/>
    <dbReference type="GeneID" id="28768745"/>
    <dbReference type="InParanoid" id="A0A177BX63"/>
    <dbReference type="OrthoDB" id="3792991at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008057428" evidence="1">
        <location>
            <begin position="17"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG00094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="149" mass="16081" checksum="615F8F5DC8E56797" modified="2016-09-07" version="1">MKITAILSVLLPTALALPLAAPAPAAAGVTTRGSTTSPNSLFAVRYRKDLISDPQKRAEPADSIFPVRYSSDVAQDSKKRSENVGFPTKYSKDVINTALKRSQPPSLFAVSYKKDVIDSKAPAAKLEKREATEGIFAVRYSKDVVPSQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BXA1</accession>
    <name>A0A177BXA1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF1769-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_359633</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441560">
        <property type="protein sequence ID" value="OAG00134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030499.1">
        <property type="nucleotide sequence ID" value="XM_018185900.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BXA1"/>
    <dbReference type="STRING" id="1460663.A0A177BXA1"/>
    <dbReference type="GeneID" id="28769386"/>
    <dbReference type="InParanoid" id="A0A177BXA1"/>
    <dbReference type="OrthoDB" id="2119945at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013897">
        <property type="entry name" value="Duc1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34826">
        <property type="entry name" value="UPF0590 PROTEIN C409.17C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34826:SF2">
        <property type="entry name" value="UPF0590 PROTEIN C409.17C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08588">
        <property type="entry name" value="Duc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Domain of unknown function at the cortex 1" evidence="2">
        <location>
            <begin position="18"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="295"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="382"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="295"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="321"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="382"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG00134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="433" mass="48418" checksum="951B8E4CD7F33FA9" modified="2016-09-07" version="1">MGRSEAGVVDPAARDKYRLQVTAGHSYDTSTHREVAVNSGEAHLIENDLMSCWLKIQIKDYNGLPHNSPETSDYFQHPLHTSDRYSIGFSFVPKRDIKGSDLVTGFDFDHSIKDRLPPGFRYAMRIVTTILDPGIYSDPYSDKPYLYGPALSSFFAFRIGEHTSDVPAEKQLASFESDAKGVIEEGAHGSGQRIRADCHIPAKTSKRRKNFLDEKKLEKFTFEAGRMYQADFFNPYLDFANFALRIPGFSISVVKYIDDKTHQLRYVLKDRSTEEVLFVVIFTLLFGRKLEETLEGTETEHGTTQEVPIKPEHETPERHASSNTSSPYETSTPSSRSRSSSAATSDYEDERETRQDRPTAAAALANSIYSGFAALGFGRAASTSTYASSKSGSPERSGKTTATPEKPKTLDEKVDEMDDHTIEELLKDKHSSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BZ30</accession>
    <name>A0A177BZ30_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Exonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1222794</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441561">
        <property type="protein sequence ID" value="OAF99787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030153.1">
        <property type="nucleotide sequence ID" value="XM_018183414.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BZ30"/>
    <dbReference type="STRING" id="1460663.A0A177BZ30"/>
    <dbReference type="GeneID" id="28766900"/>
    <dbReference type="InParanoid" id="A0A177BZ30"/>
    <dbReference type="OrthoDB" id="26838at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002562">
        <property type="entry name" value="3'-5'_exonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43040">
        <property type="entry name" value="RIBONUCLEASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43040:SF1">
        <property type="entry name" value="RIBONUCLEASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01612">
        <property type="entry name" value="DNA_pol_A_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3'-5' exonuclease" evidence="1">
        <location>
            <begin position="97"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAF99787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="282" mass="32037" checksum="480DDA2698900E72" modified="2016-09-07" version="1">MATAVVVSTVAHLAQVLDRLTLKATVPPHLYIDIEGVNLSRNGTISIFTLFDRTSKLVYLIDVYSLGFAAFTTHSATCKTFTDSVFQVIGADTAPRYVTLKTILECSKIPKVFFDVRNDSDALFAHFGIRLDGVQDLQVMELATRSGRNRERVNGLARCLHFGLVGILTPLQRSQIDTIKNRGSALFDPEKGGSFEVFNQRPLDPVIEKYCMQDVIFLPHLWLRYYKKLWVPFWKFVVASETKKRLEESRSADYVPQGKHKALGWTWDDLRQKELKWNSGSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BZ67</accession>
    <name>A0A177BZ67_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha</fullName>
            <ecNumber evidence="4">2.5.1.58</ecNumber>
            <ecNumber evidence="3">2.5.1.59</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">CAAX farnesyltransferase subunit alpha</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">FTase-alpha</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Ras proteins prenyltransferase subunit alpha</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Type I protein geranyl-geranyltransferase subunit alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CC84DRAFT_1102443</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein prenyltransferase subunit alpha family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.58" evidence="4"/>
    <dbReference type="EC" id="2.5.1.59" evidence="3"/>
    <dbReference type="EMBL" id="KV441559">
        <property type="protein sequence ID" value="OAG00271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030636.1">
        <property type="nucleotide sequence ID" value="XM_018174966.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BZ67"/>
    <dbReference type="FunCoup" id="A0A177BZ67">
        <property type="interactions" value="176"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177BZ67"/>
    <dbReference type="GeneID" id="28758452"/>
    <dbReference type="InParanoid" id="A0A177BZ67"/>
    <dbReference type="OrthoDB" id="272289at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005953">
        <property type="term" value="C:CAAX-protein geranylgeranyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005965">
        <property type="term" value="C:protein farnesyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004662">
        <property type="term" value="F:CAAX-protein geranylgeranyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004660">
        <property type="term" value="F:protein farnesyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.120">
        <property type="entry name" value="Protein prenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002088">
        <property type="entry name" value="Prenyl_trans_a"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11129">
        <property type="entry name" value="PROTEIN FARNESYLTRANSFERASE ALPHA SUBUNIT/RAB GERANYLGERANYL TRANSFERASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11129:SF1">
        <property type="entry name" value="PROTEIN FARNESYLTRANSFERASE_GERANYLGERANYLTRANSFERASE TYPE-1 SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01239">
        <property type="entry name" value="PPTA"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48439">
        <property type="entry name" value="Protein prenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51147">
        <property type="entry name" value="PFTA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0637">Prenyltransferase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00040965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00041392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00042436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00043086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00043219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OAG00271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="315" mass="36049" checksum="4B6E413B36F683E4" modified="2016-09-07" version="1">MPASDDATYYHDDPAWGDVQPLAQDDGALHPLASIAYTDEYSEAMGYLRAVMAANEYSERVLALTEHIISMNPAHYTVWLYRAKALRETGADLAREIAWLNPTALQHLKNYQIWHHRQTIVDALGSPAGEADFIATMLEQDSKNYHVWSYRQWLVQRFDLFASDDELRWTEAMIDDDVRNNSAWNHRWFLVVGGHGGRMESPRLAERELEYAKYAIRKAPQNQSPWNYIKGVVRAAGMPLSTLTSFALEFADMHRPDDIYSSHALDLLADIYADEEGSKEEAKKALDLLASRFDPIRAHYWNYRKALLEVPETAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BZ96</accession>
    <name>A0A177BZ96_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">DUF1640-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CC84DRAFT_310961</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CCDC90 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441559">
        <property type="protein sequence ID" value="OAG00545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030910.1">
        <property type="nucleotide sequence ID" value="XM_018185818.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BZ96"/>
    <dbReference type="FunCoup" id="A0A177BZ96">
        <property type="interactions" value="265"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177BZ96"/>
    <dbReference type="GeneID" id="28769304"/>
    <dbReference type="InParanoid" id="A0A177BZ96"/>
    <dbReference type="OrthoDB" id="889336at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.340:FF:000018">
        <property type="entry name" value="Mitochondrial protein FMP32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024461">
        <property type="entry name" value="CCDC90-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14360">
        <property type="entry name" value="PROTEIN FMP32, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14360:SF1">
        <property type="entry name" value="PROTEIN FMP32, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07798">
        <property type="entry name" value="CCDC90-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="248"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="175"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OAG00545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="270" mass="30863" checksum="000CAC5CDE7C4B70" modified="2016-09-07" version="1">MAASRSICRLASPRIALAPRLLRPVVFDSAVAPSRKSTSTPPLERASRAHSSSRQCLYTNTWRVGPAQQPQSITSILSSRRQFSATRAQQKDHHFDTLKFVQRLKDEGFTEEQAVAMMRVLSDVIEESIQNLTRTMVLREEQEKATYNQRVDFAKLRSELQTADSTESSLTRVSHERLTNELAKLNSRLRDEVQRTQASVRLDLNLEKGRIREEANVQELKLKETETRIEQETAQLRERLETVKFQTLQWLVGVCTGAAALMLGVWRILM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C056</accession>
    <name>A0A177C056_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">C2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CC84DRAFT_1128629</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441558">
        <property type="protein sequence ID" value="OAG01174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031539.1">
        <property type="nucleotide sequence ID" value="XM_018175804.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A177C056">
        <property type="interactions" value="44"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177C056"/>
    <dbReference type="GeneID" id="28759290"/>
    <dbReference type="InParanoid" id="A0A177C056"/>
    <dbReference type="OrthoDB" id="2015333at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd04043">
        <property type="entry name" value="C2_Munc13_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052811">
        <property type="entry name" value="Glucose_resp_signaling"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010439">
        <property type="entry name" value="MUN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014770">
        <property type="entry name" value="Munc13_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014772">
        <property type="entry name" value="Munc13_dom-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47263">
        <property type="entry name" value="ADENYLATE CYCLASE ACTIVATION PROTEIN GIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47263:SF1">
        <property type="entry name" value="C2 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_7G02350)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06292">
        <property type="entry name" value="MUN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51258">
        <property type="entry name" value="MHD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51259">
        <property type="entry name" value="MHD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MHD1" evidence="3">
        <location>
            <begin position="695"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="2">
        <location>
            <begin position="902"/>
            <end position="1016"/>
        </location>
    </feature>
    <feature type="domain" description="MHD2" evidence="4">
        <location>
            <begin position="1112"/>
            <end position="1233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="343"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="361"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAG01174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1367" mass="156937" checksum="25F2D49BC234B083" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C0C6</accession>
    <name>A0A177C0C6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Reducing type I polyketide synthase 10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CC84DRAFT_1199737</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441560">
        <property type="protein sequence ID" value="OAG00258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030623.1">
        <property type="nucleotide sequence ID" value="XM_018181637.1"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177C0C6"/>
    <dbReference type="GeneID" id="28765123"/>
    <dbReference type="InParanoid" id="A0A177C0C6"/>
    <dbReference type="OrthoDB" id="329835at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901336">
        <property type="term" value="P:lactone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05195">
        <property type="entry name" value="enoyl_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000209">
        <property type="entry name" value="Polyketide synthase Pks12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056501">
        <property type="entry name" value="NAD-bd_HRPKS_sdrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049551">
        <property type="entry name" value="PKS_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049552">
        <property type="entry name" value="PKS_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF50">
        <property type="entry name" value="HIGHLY REDUCING POLYKETIDE SYNTHASE SRDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23114">
        <property type="entry name" value="NAD-bd_HRPKS_sdrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21089">
        <property type="entry name" value="PKS_DH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="KS3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="10">
        <location>
            <begin position="30"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="11">
        <location>
            <begin position="943"/>
            <end position="1241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="8">
        <location>
            <begin position="943"/>
            <end position="1079"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="8">
        <location>
            <begin position="1092"/>
            <end position="1241"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for dehydratase activity" evidence="8">
        <location>
            <position position="975"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for dehydratase activity" evidence="8">
        <location>
            <position position="1157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OAG00258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="2372" mass="258579" checksum="3B18BDC82D63F884" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C0C8</accession>
    <name>A0A177C0C8_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ATP phosphoribosyltransferase</fullName>
            <ecNumber evidence="5">2.4.2.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CC84DRAFT_1168416</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + ATP</text>
            <dbReference type="Rhea" id="RHEA:18473"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:73183"/>
            <dbReference type="EC" id="2.4.2.17"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ATP phosphoribosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.17" evidence="5"/>
    <dbReference type="EMBL" id="KV441559">
        <property type="protein sequence ID" value="OAG00302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030667.1">
        <property type="nucleotide sequence ID" value="XM_018179391.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C0C8"/>
    <dbReference type="FunCoup" id="A0A177C0C8">
        <property type="interactions" value="185"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177C0C8"/>
    <dbReference type="GeneID" id="28762877"/>
    <dbReference type="InParanoid" id="A0A177C0C8"/>
    <dbReference type="OrthoDB" id="2574at2759"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00006"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003879">
        <property type="term" value="F:ATP phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:L-histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd13592">
        <property type="entry name" value="PBP2_HisGL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.120:FF:000003">
        <property type="entry name" value="ATP phosphoribosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.10:FF:000123">
        <property type="entry name" value="HIS1p ATP phosphoribosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00079">
        <property type="entry name" value="HisG_Long"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020621">
        <property type="entry name" value="ATP-PRT_HisG_long"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013820">
        <property type="entry name" value="ATP_PRibTrfase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018198">
        <property type="entry name" value="ATP_PRibTrfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001348">
        <property type="entry name" value="ATP_PRibTrfase_HisG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013115">
        <property type="entry name" value="HisG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011322">
        <property type="entry name" value="N-reg_PII-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015867">
        <property type="entry name" value="N-reg_PII/ATP_PRibTrfase_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00070">
        <property type="entry name" value="hisG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03455">
        <property type="entry name" value="HisG_C-term"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21403:SF8">
        <property type="entry name" value="ATP PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21403">
        <property type="entry name" value="ATP PHOSPHORIBOSYLTRANSFERASE ATP-PRTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01634">
        <property type="entry name" value="HisG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08029">
        <property type="entry name" value="HisG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54913">
        <property type="entry name" value="GlnB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01316">
        <property type="entry name" value="ATP_P_PHORIBOSYLTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 16" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="13" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 16" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ATP phosphoribosyltransferase catalytic" evidence="14">
        <location>
            <begin position="59"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine biosynthesis HisG C-terminal" evidence="15">
        <location>
            <begin position="241"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00020998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF08029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OAG00302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="317" mass="34279" checksum="73FF19A4C5D63E87" modified="2016-09-07" version="1">MEFVSSLNDRLLFAVPKKGRLNQACLDLLHGSDIQFHRHSRLDIALVKNLPLALIFLPAADIPTFVGEGRVDLGITGRDQVAEHECAEPPTATTGVVEVMDLDFGRCKLQVQVPQKGDMTKPEDLIGKNVVTSFTNLTEQYFRKLEAQQAGDATNGDATGEKTKLKTKIKYVGGSVEAACALGVADGIVDLVESGETMRAAGLHAISTVVDTSAILIKSKHPSDTKLVELITARIKGVITAQRYVLCTYNVERSKLEVASKITPGKRAPTVNSLEEDGWVAVSVMVERKQIAIVMDKLTEAGACDILVTKIENARAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C0J5</accession>
    <name>A0A177C0J5_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Sulfhydryl oxidase</fullName>
            <ecNumber evidence="6">1.8.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CC84DRAFT_1044939</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>2 R'C(R)SH + O2 = R'C(R)S-S(R)CR' + H2O2</text>
            <dbReference type="Rhea" id="RHEA:17357"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:16520"/>
            <dbReference type="ChEBI" id="CHEBI:17412"/>
            <dbReference type="EC" id="1.8.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="1.8.3.2" evidence="6"/>
    <dbReference type="EMBL" id="KV441559">
        <property type="protein sequence ID" value="OAG00328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030693.1">
        <property type="nucleotide sequence ID" value="XM_018173409.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C0J5"/>
    <dbReference type="FunCoup" id="A0A177C0J5">
        <property type="interactions" value="11"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177C0J5"/>
    <dbReference type="GeneID" id="28756895"/>
    <dbReference type="InParanoid" id="A0A177C0J5"/>
    <dbReference type="OrthoDB" id="59470at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016971">
        <property type="term" value="F:flavin-dependent sulfhydryl oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060904">
        <property type="term" value="P:regulation of protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.310:FF:000002">
        <property type="entry name" value="Sulfhydryl oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.310">
        <property type="entry name" value="ERV/ALR sulfhydryl oxidase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039799">
        <property type="entry name" value="ALR/ERV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036774">
        <property type="entry name" value="ERV/ALR_sulphydryl_oxid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017905">
        <property type="entry name" value="ERV/ALR_sulphydryl_oxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12645">
        <property type="entry name" value="ALR/ERV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12645:SF1">
        <property type="entry name" value="FAD-LINKED SULFHYDRYL OXIDASE ERV2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04777">
        <property type="entry name" value="Evr1_Alr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69000">
        <property type="entry name" value="FAD-dependent thiol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51324">
        <property type="entry name" value="ERV_ALR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 6" id="KW-0274">FAD</keyword>
    <keyword evidence="2 6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008057537" description="Sulfhydryl oxidase" evidence="7">
        <location>
            <begin position="24"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="ERV/ALR sulfhydryl oxidase" evidence="8">
        <location>
            <begin position="56"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU371123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAG00328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="164" mass="17791" checksum="FAAA33199DFB9EB5" modified="2016-09-07" version="1" fragment="single">LLALFGMALFTFLILGGHRSIDGQPSPIQQAKLNTQGGGSSGAVLTGHAIAPKLGNATAKAELGRAAWKVLHTTFARFPEKPTEEEKEALRSYVHLFQRLYPCGECAEHFGKVLAKYPPQVSSRSAAAMWGCMVHNIVNKRLKKPEFNCEDIGDAYDCGCGDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C112</accession>
    <name>A0A177C112_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Isocitrate dehydrogenase [NAD] subunit 1, mitochondrial</fullName>
            <ecNumber evidence="5">1.1.1.41</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Isocitric dehydrogenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">NAD(+)-specific ICDH</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CC84DRAFT_1168509</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-threo-isocitrate + NAD(+) = 2-oxoglutarate + CO2 + NADH</text>
            <dbReference type="Rhea" id="RHEA:23632"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.41"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Octamer of two non-identical subunits IDH1 and IDH2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the isocitrate and isopropylmalate dehydrogenases family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.41" evidence="5"/>
    <dbReference type="EMBL" id="KV441559">
        <property type="protein sequence ID" value="OAG00407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030772.1">
        <property type="nucleotide sequence ID" value="XM_018179413.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C112"/>
    <dbReference type="FunCoup" id="A0A177C112">
        <property type="interactions" value="698"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177C112"/>
    <dbReference type="GeneID" id="28762899"/>
    <dbReference type="InParanoid" id="A0A177C112"/>
    <dbReference type="OrthoDB" id="10261637at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045242">
        <property type="term" value="C:isocitrate dehydrogenase complex (NAD+)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042645">
        <property type="term" value="C:mitochondrial nucleoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004449">
        <property type="term" value="F:isocitrate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006102">
        <property type="term" value="P:isocitrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.718.10:FF:000001">
        <property type="entry name" value="Isocitrate dehydrogenase [NAD] subunit, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.718.10">
        <property type="entry name" value="Isopropylmalate Dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019818">
        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004434">
        <property type="entry name" value="Isocitrate_DH_NAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00175">
        <property type="entry name" value="mito_nad_idh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11835">
        <property type="entry name" value="DECARBOXYLATING DEHYDROGENASES-ISOCITRATE, ISOPROPYLMALATE, TARTRATE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11835:SF42">
        <property type="entry name" value="ISOCITRATE DEHYDROGENASE [NAD] SUBUNIT BETA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53659">
        <property type="entry name" value="Isocitrate/Isopropylmalate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="6" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Isopropylmalate dehydrogenase-like" evidence="13">
        <location>
            <begin position="52"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00071938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OAG00407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="386" mass="42268" checksum="496228BFE927BD43" modified="2016-09-07" version="1">MLSRSSQKTAQTLLRGARPASRCIAGPSMATRSMATVNHDIFKPTKFGGKYTVTLIPGDGIGAEVSESVKQIFKADNVPIEWEQVNVTGVETGNKHSEELFREAIASLKRNKLGLKGILHTPIERSGHQSFNVALRQELDIYASIVLIKNIPGYETRHKNIDLCIIRENTEGEYSGLEHQSVDGVVESLKIITRAKSERIAKFAFAFALANNRKKVTCIHKANIMKLADGLFRNTCKKVSEDYPTIEYNDMIVDNASMQCVSRPQQFDVMVMPNLYGGILSNIGAGLVGGPGIVPGCNMGRNVAVFEPGCRHVGLDIKGKDQANPSALILSAAMLLRHLGLDDHANRISQSVYRVIEDGQVRTRDMGGNSTTQEFTRAILAAMEKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C1H1</accession>
    <name>A0A177C1H1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nucleoside 2-deoxyribosyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1168741</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441559">
        <property type="protein sequence ID" value="OAG00682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031047.1">
        <property type="nucleotide sequence ID" value="XM_018179472.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C1H1"/>
    <dbReference type="GeneID" id="28762958"/>
    <dbReference type="InParanoid" id="A0A177C1H1"/>
    <dbReference type="OrthoDB" id="2893324at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039470">
        <property type="entry name" value="Nuc_deoxyri_tr2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15891">
        <property type="entry name" value="Nuc_deoxyri_tr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG00682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="291" mass="32152" checksum="5375F867F31DBF60" modified="2016-09-07" version="1">MSDPHPAAPVTNTEGWSEEDIALLKAFKDPTACKFCKRPSRCQECNHELVPEPKRPAGKQNIDVPRPDLFGQLPPPIANPARHRDFSVQFPPEALALGAFSVFAAGSIEMGKAIPWQRLLENHLCDLPITICNPRRGQWDPAVTQRAKDAAFREQVEWELGALTASTVICFFFDHATMSPVTLMELGLWAHSNKVVVCCNGDYWKGGNVHIVCERYGVPVVESFSELVPLVRAMLRTKGCIVGKSGNLTENEAERDPERSMSLDEAEGVLKGALREKQGIAIDRKQLGIAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C1T6</accession>
    <name>A0A177C1T6_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">3CxxC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CC84DRAFT_1189984</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441557">
        <property type="protein sequence ID" value="OAG01744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032109.1">
        <property type="nucleotide sequence ID" value="XM_018181085.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C1T6"/>
    <dbReference type="STRING" id="1460663.A0A177C1T6"/>
    <dbReference type="GeneID" id="28764571"/>
    <dbReference type="InParanoid" id="A0A177C1T6"/>
    <dbReference type="OrthoDB" id="8121437at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027377">
        <property type="entry name" value="ZAR1/RTP1-5-like_Znf-3CxxC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13695">
        <property type="entry name" value="Zn_ribbon_3CxxC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01328">
        <property type="entry name" value="zf-3CxxC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="3CxxC-type" evidence="4">
        <location>
            <begin position="46"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAG01744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="149" mass="17095" checksum="692620CA3A1D1B40" modified="2016-09-07" version="1">MEKPPKFSLHPELHGAVSLHLADDDLHFSFRQDRSDARSTKAWNSNIRGVFICYNNKCPSRSWASGMVAIRILLYAGQQYHAQVYHQRCEQCNFVSKPRLDDSYAERVARRLKIWSGVKVESVPRRGQSKRPHLTELCEGCRAGYCSNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C2J0</accession>
    <name>A0A177C2J0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1053813</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441558">
        <property type="protein sequence ID" value="OAG00850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031215.1">
        <property type="nucleotide sequence ID" value="XM_018173511.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C2J0"/>
    <dbReference type="GeneID" id="28756997"/>
    <dbReference type="InParanoid" id="A0A177C2J0"/>
    <dbReference type="OrthoDB" id="4148767at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="15"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG00850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="278" mass="31337" checksum="C831243B66E0DE5B" modified="2016-09-07" version="1" fragment="single">MGVTVSHTTLAPVSLASTLIGFISFAFTLATFLKVFWQSIITLKAAPDEITDYLSNLKQALLEERRHLRKVRRRARKRSRGDDGGSWVGGGTGGRRSRSRRRSGGGGGGGKGPRSYFERDEQAFRSQGESEALRVMRDAIRDMIRSFRVLEYPFLKPEFQDLDSARWSTNTPREKSPAYLQSPPEGSPWEDDDGEQAQAQGLSRSNRYGSEYKKCGMRERWLWLHRKGDVVTMSEGLSRIEVRRTAHEVGAVAMAVTDIGRDVEGMFEMIRAMEGRLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C2M1</accession>
    <name>A0A177C2M1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1208067</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441556">
        <property type="protein sequence ID" value="OAG01893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032258.1">
        <property type="nucleotide sequence ID" value="XM_018182140.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C2M1"/>
    <dbReference type="GeneID" id="28765626"/>
    <dbReference type="InParanoid" id="A0A177C2M1"/>
    <dbReference type="OrthoDB" id="5394791at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008057707" evidence="1">
        <location>
            <begin position="19"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG01893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="220" mass="23709" checksum="AAF766269A728760" modified="2016-09-07" version="1">MHILNLLNLAVFASLAAASPTAGAEALSSPEQAVGVPLEKRACTYTGCTCLKGIKAGVYCGNCYNPKDHNYWAVQTKGSSSRFATHAFQCASSGDCCDYGVASDCGKTSARCYYNGTPCSPTVKIDDPLISSARPFDASTSQLTHANFPRISLAAGRSLSRRGPKKAIILVPAWAKARAVALPILRKKHQSAKRWLPQKNYLRIYKPSTSSCDEHDTIFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C2M6</accession>
    <name>A0A177C2M6_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">YDG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CC84DRAFT_1168288</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441558">
        <property type="protein sequence ID" value="OAG01149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031514.1">
        <property type="nucleotide sequence ID" value="XM_018179362.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C2M6"/>
    <dbReference type="STRING" id="1460663.A0A177C2M6"/>
    <dbReference type="GeneID" id="28762848"/>
    <dbReference type="InParanoid" id="A0A177C2M6"/>
    <dbReference type="OrthoDB" id="2270193at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044027">
        <property type="term" value="P:negative regulation of gene expression via chromosomal CpG island methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.280.10">
        <property type="entry name" value="SRA-YDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036987">
        <property type="entry name" value="SRA-YDG_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003105">
        <property type="entry name" value="SRA_YDG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045134">
        <property type="entry name" value="UHRF1/2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14140">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE UHRF-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14140:SF27">
        <property type="entry name" value="OS04G0289800 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02182">
        <property type="entry name" value="SAD_SRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00466">
        <property type="entry name" value="SRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51015">
        <property type="entry name" value="YDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YDG" evidence="4">
        <location>
            <begin position="345"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="94"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="94"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="117"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="161"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAG01149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="515" mass="58855" checksum="544AC22A99B473B4" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2023-06-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C315</accession>
    <name>A0A177C315_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1167985</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441557">
        <property type="protein sequence ID" value="OAG01855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032220.1">
        <property type="nucleotide sequence ID" value="XM_018179297.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C315"/>
    <dbReference type="GeneID" id="28762783"/>
    <dbReference type="InParanoid" id="A0A177C315"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG01855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="180" mass="20233" checksum="37B577D8AC4215C7" modified="2016-09-07" version="1">MWCPQRNVVKNVNRTKSDWSRRSLRLVGGRRGARDCWLYTPALLGDWPAPSHAPQICAFWAQRMHDPIKVRVPPEGPIFQRIRCLGSRTVVLHSSNLARSPHVRCFWAPWCDQRILGRPLGTCRSRVVAIGRACSGILEACQRSASYGGKQAEQALTKLYQTMYAGCFSTHLDAACGRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2023-06-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C318</accession>
    <name>A0A177C318_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_276169</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441558">
        <property type="protein sequence ID" value="OAG01060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031425.1">
        <property type="nucleotide sequence ID" value="XM_018185716.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C318"/>
    <dbReference type="GeneID" id="28769202"/>
    <dbReference type="InParanoid" id="A0A177C318"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG01060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="147" mass="16321" checksum="F9010A30C0E917AA" modified="2016-09-07" version="1">MQGFLYQFAACPVFLRSRTASHQTSIPPCSFSGFLIPGAAFCPQLSASPLAWLDCGRFSNTCWLCLLPWEEHHLCASVSSYIVECIALPEPRLLLNCSAFVSLSPKLPFKYPAHFSRLYPNSIFGASLRLPSARWKPASPRPRLLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C365</accession>
    <name>A0A177C365_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1101515</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441558">
        <property type="protein sequence ID" value="OAG01228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031593.1">
        <property type="nucleotide sequence ID" value="XM_018174917.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C365"/>
    <dbReference type="GeneID" id="28758403"/>
    <dbReference type="InParanoid" id="A0A177C365"/>
    <dbReference type="OrthoDB" id="3941101at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG01228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="276" mass="30625" checksum="4A413779E6E7C761" modified="2016-09-07" version="1">MLAGRPSTLGAALLEDDAPPYDATGAQREDLPQYEPPAPSHNREAHEVPLHTYYLRAPDRKNLVAVPYGLSAPGSFKFTSRGSRLFSKKPEMDVWRSVRASAPTEDEYVAGIWFDTDGPLPWCPRARFVRQDPTAGNQTYKMEARNFSDWTISVDGTLYSWILEAKPFSLVLRQDGRQDAVARFNFSACGLVATGGAEVGDLTLYRDGLSQDKAGVDVILCGLVTALLQFKKMGRHYKNEPDAIAQRAMLPEERVPLHRSGVAQFWSYQQDGSTIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C3U8</accession>
    <name>A0A177C3U8_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1126927</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441557">
        <property type="protein sequence ID" value="OAG01340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031705.1">
        <property type="nucleotide sequence ID" value="XM_018175757.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C3U8"/>
    <dbReference type="STRING" id="1460663.A0A177C3U8"/>
    <dbReference type="GeneID" id="28759243"/>
    <dbReference type="InParanoid" id="A0A177C3U8"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037381">
        <property type="entry name" value="RFWD3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16047:SF7">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RFWD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16047">
        <property type="entry name" value="RFWD3 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="2">
        <location>
            <begin position="26"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG01340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="334" mass="36371" checksum="7FC9F77FD14D449E" modified="2016-09-07" version="1" fragment="single">MSPPMSASPTTMDNFIRTKLQPSGSCIICTDPFSASHQPVALPCHHIFGHACIKNWLHNGRGATNNCPICRAEIYPSDGGAFTSASIWTALCAASPDRIHDFLSALWPRVAALFADDPTGTFTTRDLLSQAVLPALRSMHNSDATGPFTDAHSLIASTWNSLGRPNSASGLAIPLVRLARLMAQTSSILPKWITTVPRTSLLFWRANACLGTSSCEISWAPLAEAAGLANARYFPFLHLYTVLLSQHIVHARPTHTGPSHSSIIERCCTKIGGEWAGKPGDGFKESVVGVYEELRRHQLEEKRISLRGHEEEKGVVTGLWAMAGWRREDARKPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C3V6</accession>
    <name>A0A177C3V6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Beach-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CC84DRAFT_1167212</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441556">
        <property type="protein sequence ID" value="OAG02086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032451.1">
        <property type="nucleotide sequence ID" value="XM_018179139.1"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177C3V6"/>
    <dbReference type="GeneID" id="28762625"/>
    <dbReference type="InParanoid" id="A0A177C3V6"/>
    <dbReference type="OrthoDB" id="26681at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06071">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01201">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1540.10">
        <property type="entry name" value="BEACH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056252">
        <property type="entry name" value="Alfy-like_Arm-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000409">
        <property type="entry name" value="BEACH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036372">
        <property type="entry name" value="BEACH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051944">
        <property type="entry name" value="BEACH_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023362">
        <property type="entry name" value="PH-BEACH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46108">
        <property type="entry name" value="BLUE CHEESE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46108:SF4">
        <property type="entry name" value="BLUE CHEESE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23295">
        <property type="entry name" value="Arm_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02138">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13385">
        <property type="entry name" value="Laminin_G_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14844">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01026">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81837">
        <property type="entry name" value="BEACH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50197">
        <property type="entry name" value="BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51783">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="BEACH-type PH" evidence="6">
        <location>
            <begin position="1829"/>
            <end position="1963"/>
        </location>
    </feature>
    <feature type="domain" description="BEACH" evidence="5">
        <location>
            <begin position="2002"/>
            <end position="2294"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="2427"/>
            <end position="2468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="952"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1781"/>
            <end position="1801"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="952"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="977"/>
            <end position="988"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAG02086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="2662" mass="299700" checksum="861CD77A1E11F0EB" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C4B5</accession>
    <name>A0A177C4B5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1167891</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441557">
        <property type="protein sequence ID" value="OAG01729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032094.1">
        <property type="nucleotide sequence ID" value="XM_018179281.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C4B5"/>
    <dbReference type="GeneID" id="28762767"/>
    <dbReference type="InParanoid" id="A0A177C4B5"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG01729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="87" mass="9473" checksum="2A691333256FE797" modified="2016-09-07" version="1">MLSRRLCTPGGVVVASCPGTQAIIPRRPADDRPNTLARLPLNGFTAEAHPSISSQQSHLAKRGGPRSPHYHKSTYIGLQQVSNLLRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C4J2</accession>
    <name>A0A177C4J2_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Selenoprotein O</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CC84DRAFT_1167817</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SELO family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441557">
        <property type="protein sequence ID" value="OAG01647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032012.1">
        <property type="nucleotide sequence ID" value="XM_018179269.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C4J2"/>
    <dbReference type="FunCoup" id="A0A177C4J2">
        <property type="interactions" value="316"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177C4J2"/>
    <dbReference type="GeneID" id="28762755"/>
    <dbReference type="InParanoid" id="A0A177C4J2"/>
    <dbReference type="OrthoDB" id="10254721at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070733">
        <property type="term" value="F:AMPylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00692">
        <property type="entry name" value="SelO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003846">
        <property type="entry name" value="SelO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32057">
        <property type="entry name" value="PROTEIN ADENYLYLTRANSFERASE SELO, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32057:SF14">
        <property type="entry name" value="PROTEIN ADENYLYLTRANSFERASE SELO, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02696">
        <property type="entry name" value="SelO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="281"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="24"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OAG01647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="628" mass="70963" checksum="4F5E2F5C0BC7873D" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C4M1</accession>
    <name>A0A177C4M1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Transcription elongation factor SPT4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CC84DRAFT_1099753</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">The SPT4-SPT5 complex mediates both activation and inhibition of transcription elongation, and plays a role in pre-mRNA processing. This complex seems to be important for the stability of the RNA polymerase II elongation machinery on the chromatin template but not for the inherent ability of this machinery to translocate down the gene.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Centromere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the SPT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441557">
        <property type="protein sequence ID" value="OAG01822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032187.1">
        <property type="nucleotide sequence ID" value="XM_018174838.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C4M1"/>
    <dbReference type="FunCoup" id="A0A177C4M1">
        <property type="interactions" value="444"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177C4M1"/>
    <dbReference type="GeneID" id="28758324"/>
    <dbReference type="InParanoid" id="A0A177C4M1"/>
    <dbReference type="OrthoDB" id="248751at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032044">
        <property type="term" value="C:DSIF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031934">
        <property type="term" value="C:mating-type region heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033553">
        <property type="term" value="C:rDNA heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000182">
        <property type="term" value="F:rDNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000993">
        <property type="term" value="F:RNA polymerase II complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003727">
        <property type="term" value="F:single-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006370">
        <property type="term" value="P:7-methylguanosine mRNA capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031507">
        <property type="term" value="P:heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008298">
        <property type="term" value="P:intracellular mRNA localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010507">
        <property type="term" value="P:negative regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001208">
        <property type="term" value="P:negative regulation of transcription elongation by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001209">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000232">
        <property type="term" value="P:regulation of rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090262">
        <property type="term" value="P:regulation of transcription-coupled nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140673">
        <property type="term" value="P:transcription elongation-coupled chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07973">
        <property type="entry name" value="Spt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029040">
        <property type="entry name" value="RPABC4/Spt4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009287">
        <property type="entry name" value="Spt4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022800">
        <property type="entry name" value="Spt4/RpoE2_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038510">
        <property type="entry name" value="Spt4_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12882">
        <property type="entry name" value="SUPPRESSOR OF TY 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12882:SF1">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR SPT4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06093">
        <property type="entry name" value="Spt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF025023">
        <property type="entry name" value="Spt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01389">
        <property type="entry name" value="Spt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63393">
        <property type="entry name" value="RNA polymerase subunits"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0137">Centromere</keyword>
    <keyword evidence="10" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="Spt4/RpoE2 zinc finger" evidence="9">
        <location>
            <begin position="16"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR025023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAG01822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="126" mass="13865" checksum="99CC5A00459D365B" modified="2016-09-07" version="1">MANANNFVPTNQLRNLRACMVCSIVKTENQFKSQGCPNCESFLQLRGEDEQVRACTSQVFEGLITVSNTTKSWVARWQRLEGYVPGVYAVQVEGLLPEDVISAAEDAGVHYIPRDGSVNEALPTDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C5I2</accession>
    <name>A0A177C5I2_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF1996 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1251904</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441556">
        <property type="protein sequence ID" value="OAG01940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032305.1">
        <property type="nucleotide sequence ID" value="XM_018184348.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C5I2"/>
    <dbReference type="STRING" id="1460663.A0A177C5I2"/>
    <dbReference type="GeneID" id="28767834"/>
    <dbReference type="InParanoid" id="A0A177C5I2"/>
    <dbReference type="OrthoDB" id="74764at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018535">
        <property type="entry name" value="DUF1996"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43662">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43662:SF2">
        <property type="entry name" value="DUF1996 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09362">
        <property type="entry name" value="DUF1996"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1996" evidence="1">
        <location>
            <begin position="15"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG01940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="337" mass="37541" checksum="202193B1020D8E98" modified="2016-09-07" version="1">MMRFACSQLTVERLDPLVNPGQIGTPHTHQIVGGNSFRPDMEPVKYDLPTESTCTSCTFSEDFSNYWTAALYFRARNGTYKRVKQVSNGGLHQDGGHTVYYIPTYDGVSNVTAFAPGFRMLAGNPMLRNTTGESRGICHRCLFKDQQPFGGAPCTGNDTTHLPDHQCEGGIRTQVTFPTCWDGKNLDSPDHQSHVAYATIPFEPYADPVVSRPYTPELERGKCPDTHPVHLPQLMYEVIFDTTEFNGEGMWPEDGSQPLVFSMGDATGHGNHGDYMFGWKGDSLQRAINARCDNDHCKELTRQTDEEAMKCKIAQKAVEDVGNDNCKLSLREGSKVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C624</accession>
    <name>A0A177C624_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Guanine nucleotide-binding protein, beta subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CC84DRAFT_938913</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat G protein beta family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG02975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033340.1">
        <property type="nucleotide sequence ID" value="XM_018187927.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C624"/>
    <dbReference type="FunCoup" id="A0A177C624">
        <property type="interactions" value="436"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177C624"/>
    <dbReference type="GeneID" id="28771413"/>
    <dbReference type="InParanoid" id="A0A177C624"/>
    <dbReference type="OrthoDB" id="10255630at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000020">
        <property type="entry name" value="Guanine nucleotide-binding protein beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016346">
        <property type="entry name" value="G-protein_beta_1-5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001632">
        <property type="entry name" value="WD40_G-protein_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19850">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN BETA G PROTEIN BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25391">
        <property type="entry name" value="WD40_Gbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002394">
        <property type="entry name" value="GN-bd_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00319">
        <property type="entry name" value="GPROTEINB"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="61"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="149"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="190"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="233"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="284"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="319"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="6"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAG02975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="351" mass="39030" checksum="287C1D7F2B1E4DF1" modified="2016-09-07" version="1">MADMSAESIQQKIQIARRDAEALKDRIKRKKDELADTTLRDVAKQRVEALPRLSMKTKRTLKGHLAKIYAMHWSTDRRHLVSASQDGKLIIWDAYTTNKVHAIPLRSSWVMTCAYSPSGNYVACGGLDNICSIYNLSAREGPTRVARELSGHSGYLSCCRFISDKRILTSSGDMTCVLWDLETGSKVHEFADHLGDVMSLSINPLDHNQFVSGACDAFAKLWDIRQQKCVQTFAAHDSDINAIQFFPNGNAFGTGSDDASCRLFDIRADRELQAYTIPEPVCGITSVAFSVSGRLLFAGYDDFECKVWDVLRGERVGTLQGHDNRVSCLGVSNDALSLCTGSWDSMLRIWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C883</accession>
    <name>A0A177C883_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Chromosome segregation ATPase family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1095072</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG03616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033981.1">
        <property type="nucleotide sequence ID" value="XM_018174596.1"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177C883"/>
    <dbReference type="GeneID" id="28758082"/>
    <dbReference type="InParanoid" id="A0A177C883"/>
    <dbReference type="OrthoDB" id="5423371at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23159">
        <property type="entry name" value="CENTROSOMAL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23159:SF31">
        <property type="entry name" value="CENTROSOME-ASSOCIATED PROTEIN CEP250 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="182"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="271"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1929"/>
            <end position="1961"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2072"/>
            <end position="2206"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1408"/>
            <end position="1435"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1646"/>
            <end position="1680"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1802"/>
            <end position="1911"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="10"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="34"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="58"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="138"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="200"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="276"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="2142"/>
            <end position="2161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="2184"/>
            <end position="2202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG03616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2268" mass="249826" checksum="258FFE0A56AB3459" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C8K0</accession>
    <name>A0A177C8K0_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CENP-V/GFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CC84DRAFT_1219132</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfa family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG03875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034240.1">
        <property type="nucleotide sequence ID" value="XM_018183057.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C8K0"/>
    <dbReference type="GeneID" id="28766543"/>
    <dbReference type="InParanoid" id="A0A177C8K0"/>
    <dbReference type="OrthoDB" id="2993351at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016846">
        <property type="term" value="F:carbon-sulfur lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052355">
        <property type="entry name" value="CENP-V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006913">
        <property type="entry name" value="CENP-V/GFA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28620:SF1">
        <property type="entry name" value="CENP-V_GFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28620">
        <property type="entry name" value="CENTROMERE PROTEIN V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04828">
        <property type="entry name" value="GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51891">
        <property type="entry name" value="CENP_V_GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CENP-V/GFA" evidence="4">
        <location>
            <begin position="10"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAG03875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="132" mass="15212" checksum="F58445DFE346AE40" modified="2016-09-07" version="1">MATNKTSQRYQASCHCQLIRYTVTLSPPLHDPESWVVECNCSICARNGYLNVYVQNECIQFDNVDLNSNLVEKYRFGKERVQHYFCSRCGSSLMAESIEPGFYEGVKALNVRMFQGVDVRTLQRREVDGRSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C8K1</accession>
    <name>A0A177C8K1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">cAMP-independent regulatory protein pac2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_864889</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG03726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034091.1">
        <property type="nucleotide sequence ID" value="XM_018187695.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C8K1"/>
    <dbReference type="GeneID" id="28771181"/>
    <dbReference type="InParanoid" id="A0A177C8K1"/>
    <dbReference type="OrthoDB" id="5572844at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018608">
        <property type="entry name" value="Gti1/Pac2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28027:SF1">
        <property type="entry name" value="CAMP INDEPENDENT REGULATORY PROTEIN (AFU_ORTHOLOGUE AFUA_3G09640)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28027">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR MIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09729">
        <property type="entry name" value="Gti1_Pac2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="274"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="274"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="321"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="360"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="399"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG03726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="450" mass="49264" checksum="D04F790E72E5BAE3" modified="2016-09-07" version="1">METYHGHVRTPNDAILLFEACRIGLLPRVQRRLSEKERQQIKSGSVFVWDEREAGMRRWTDGKSWSASRVSGSFLTYREMEGKRGGSNLNQPAPKRASGKSPDGSATGDSEGEGPDGYRYKPDGLMKQSFSITTSSGQHLHLISYYSRSNSMPLQQPSTDSSLRHIRPPKNMYPESTVNETQPVAAVTRGPLPGSPYAQSPHQMPTSPYSRPGPPQQPVYVPVYHPPTPPSGTPPYQHAYYGQPHYPYFQYAPLIYAPPGYPPQPGHVFDRPPPQMAHPGIPHPPPGHVAMAPHPGHHPQYIQQPPPHPLQRPELVQRPTGPIPPAPPAAPIPEQGPQLPAINSTTPTSAHRPPTPQPSEPQSQGSLAPPEPNSAANEPSPARTIPKIGSILNNHEQSGDNQNNSRSGSRSPNGTQPPIRELPPDRLASMSTATDSRALDKLNRNMFVRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C8K6</accession>
    <name>A0A177C8K6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative benzoate 4-monooxygenase cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CC84DRAFT_1151599</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG03192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033557.1">
        <property type="nucleotide sequence ID" value="XM_018176755.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C8K6"/>
    <dbReference type="STRING" id="1460663.A0A177C8K6"/>
    <dbReference type="GeneID" id="28760241"/>
    <dbReference type="InParanoid" id="A0A177C8K6"/>
    <dbReference type="OrthoDB" id="3945418at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11062">
        <property type="entry name" value="CYP58-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF157">
        <property type="entry name" value="N-ACETYLTRYPTOPHAN 6-HYDROXYLASE IVOC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7 8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8 10" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="469"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAG03192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="532" mass="61083" checksum="FE410FD3889BD796" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C997</accession>
    <name>A0A177C997_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transcription initiation factor TFIID subunit 12 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_1188140</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF12 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG03432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033797.1">
        <property type="nucleotide sequence ID" value="XM_018180973.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C997"/>
    <dbReference type="STRING" id="1460663.A0A177C997"/>
    <dbReference type="GeneID" id="28764459"/>
    <dbReference type="InParanoid" id="A0A177C997"/>
    <dbReference type="OrthoDB" id="2193432at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07981">
        <property type="entry name" value="HFD_TAF12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000037">
        <property type="entry name" value="Transcription initiation factor TFIID subunit 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037794">
        <property type="entry name" value="TAF12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003228">
        <property type="entry name" value="TFIID_TAF12_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12264">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12264:SF21">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03847">
        <property type="entry name" value="TFIID_20kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription initiation factor TFIID subunit 12" evidence="7">
        <location>
            <begin position="533"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="80"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="251"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="84"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="251"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="263"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="330"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="385"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="403"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="453"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAG03432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="643" mass="71567" checksum="3E050229C2CAE8EF" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C9R1</accession>
    <name>A0A177C9R1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BAG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1056927</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG03460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033825.1">
        <property type="nucleotide sequence ID" value="XM_018173548.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C9R1"/>
    <dbReference type="STRING" id="1460663.A0A177C9R1"/>
    <dbReference type="GeneID" id="28757034"/>
    <dbReference type="InParanoid" id="A0A177C9R1"/>
    <dbReference type="OrthoDB" id="4186058at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003103">
        <property type="entry name" value="BAG_domain"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51035">
        <property type="entry name" value="BAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BAG" evidence="2">
        <location>
            <begin position="105"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="271"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG03460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="290" mass="32660" checksum="B303D377AD102C80" modified="2016-09-07" version="1" fragment="single">METTERAPVFTFANGPSSPPMTPGTRSHTHFLHKDDHPTSSYKRMAMVHNAQSPPLEFIKPIGQGPQFHFTRPQSRGASSRPSTASVACATTPQDSEDDDASDEESICEDARQFRRAEEEDISFILEYLDSEPGYDSDIEVVRPDQFEDAKSDRSKSRLDDNGITAEINDMHLADDSSEDEELRQRMDWKKKKRWSARMYKTKRTYSMSVEGDSSYSDNDPCDDVDESARRLRRRVRGPGDRTSLIFEDGGFPNINNIAEVEEPEDGGIVVKKVQGPPSIPSDDAFTLDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C9X2</accession>
    <name>A0A177C9X2_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">dihydroorotase</fullName>
            <ecNumber evidence="4">3.5.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CC84DRAFT_1149066</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 3/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class II DHOase subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.5.2.3" evidence="4"/>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG03557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033922.1">
        <property type="nucleotide sequence ID" value="XM_018176655.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C9X2"/>
    <dbReference type="FunCoup" id="A0A177C9X2">
        <property type="interactions" value="276"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177C9X2"/>
    <dbReference type="GeneID" id="28760141"/>
    <dbReference type="InParanoid" id="A0A177C9X2"/>
    <dbReference type="OrthoDB" id="1670005at2759"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00117"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004151">
        <property type="term" value="F:dihydroorotase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000041">
        <property type="entry name" value="Dihydroorotase, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00219">
        <property type="entry name" value="PyrC_classII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004721">
        <property type="entry name" value="DHOdimr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002195">
        <property type="entry name" value="Dihydroorotase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00856">
        <property type="entry name" value="pyrC_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43137">
        <property type="entry name" value="DIHYDROOROTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43137:SF1">
        <property type="entry name" value="DIHYDROOROTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001237">
        <property type="entry name" value="DHOdimr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00482">
        <property type="entry name" value="DIHYDROOROTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00483">
        <property type="entry name" value="DIHYDROOROTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAG03557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="368" mass="40592" checksum="A25E524E0B7A5539" modified="2016-09-07" version="1">MEFTKIQEIELPAAFDAHVHLRDGEMSQLVTPTIRQGGVNQVYVMPNLVPPVTTVQQCLEYRDRLRAIEPNVDYLMSLYLHESVTPEVIREAKKAGITGVKSYPAGVTTNSSSGVISYEPFYPVFAEMEKQNMVLNLHGEVPSTPSHAHASTSKDQAITILNAEPAFLPTLKSLHEKFPTLRIILEHCSTAAALAAVRACGPAVAGTITAHHLSLVIDDWAGDPFCFCKPVAKTPEDRDALLQAVVRSEGRFFLGTDSAPHDQGKKRGEDKVAAGVFTQTNAVAYVLDALEKGVERGVIEEKEVSQEGLEGFLGRWGRKFYQVKDERGEKVVLRKGQAKVVEVLEKEGVSVKIVPFRRGETTWSVEWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CA90</accession>
    <name>A0A177CA90_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_861565</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG03640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034005.1">
        <property type="nucleotide sequence ID" value="XM_018187671.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CA90"/>
    <dbReference type="GeneID" id="28771157"/>
    <dbReference type="InParanoid" id="A0A177CA90"/>
    <dbReference type="OrthoDB" id="10335404at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG03640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="150" mass="16530" checksum="7BA3E8EE782004A7" modified="2016-09-07" version="1">MDSSYFVDRGFHEFQNNYPPNGLNSNHLNIFGQQSQQRHSEQYQHQPLSPGQPRSRGSSFNGSPTSPTSAHRSSMSQPSVTQSNHSYFSIGNTGPLPPTPSPVTATYDMSRSDSMNSGFDYGYGGNYNQMSMHGGNGIVKLNDSENHHEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CAN6</accession>
    <name>A0A177CAN6_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1249207</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG03828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034193.1">
        <property type="nucleotide sequence ID" value="XM_018184275.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CAN6"/>
    <dbReference type="GeneID" id="28767761"/>
    <dbReference type="InParanoid" id="A0A177CAN6"/>
    <dbReference type="OrthoDB" id="3727384at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008057946" description="Ig-like domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="560"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG03828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="560" mass="60784" checksum="34A7CA2DC1B0C0B7" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CAW9</accession>
    <name>A0A177CAW9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cellobiose dehydrogenase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CC84DRAFT_1121628</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG04864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035229.1">
        <property type="nucleotide sequence ID" value="XM_018175617.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CAW9"/>
    <dbReference type="STRING" id="1460663.A0A177CAW9"/>
    <dbReference type="GeneID" id="28759103"/>
    <dbReference type="InParanoid" id="A0A177CAW9"/>
    <dbReference type="OrthoDB" id="413885at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09630">
        <property type="entry name" value="CDH_like_cytochrome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1210">
        <property type="entry name" value="Cellobiose dehydrogenase, cytochrome domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.410.10">
        <property type="entry name" value="Cholesterol Oxidase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015920">
        <property type="entry name" value="Cellobiose_DH-like_cyt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-dep_OxRdtase_2_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053208">
        <property type="entry name" value="GMC_Oxidoreductase_CD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47190:SF2">
        <property type="entry name" value="CELLOBIOSE DEHYDROGENASE (AFU_ORTHOLOGUE AFUA_2G17620)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47190">
        <property type="entry name" value="DEHYDROGENASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16010">
        <property type="entry name" value="CDH-cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49344">
        <property type="entry name" value="CBD9-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00623">
        <property type="entry name" value="GMC_OXRED_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="2 4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008057913" evidence="6">
        <location>
            <begin position="24"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="7">
        <location>
            <begin position="327"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="8">
        <location>
            <begin position="492"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="205"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="207"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAG04864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="780" mass="82490" checksum="DA7C3675C210ABC9" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CB92</accession>
    <name>A0A177CB92_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">FAD-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_1166229</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG04119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034484.1">
        <property type="nucleotide sequence ID" value="XM_018178901.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CB92"/>
    <dbReference type="STRING" id="1460663.A0A177CB92"/>
    <dbReference type="GeneID" id="28762387"/>
    <dbReference type="InParanoid" id="A0A177CB92"/>
    <dbReference type="OrthoDB" id="407275at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF39">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008057957" evidence="6">
        <location>
            <begin position="24"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="7">
        <location>
            <begin position="61"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAG04119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="499" mass="52829" checksum="A87FEDB844203CCB" modified="2016-09-07" version="1">MLHTSSHGQQLLILLGFLAAGLCQDQKADSIRACLDQGGVQATISTDATWAKDTAAFQFRIAPEPVAVALPQDKSQVATALSCARNASVKVSAVGRAHSFQGYGYGNPGNLVIDMQAFTGLSFDNATNQLTFGGGANVGPAAKYLWDNHRRHFPHVRGSHVGLAGSTMGGGFGTTSRFLGIPTDNLASVEFMLHNGSIVTGGPGSDLHWAAQGAGPSFGIVLSATLNTHAIPIDGAVSYSLTLGDVDVDIASAALLKIQQWVTSGQAPDELSLRFQLGTFASAGFFYGVESDFDRAFAPLVESVRSVAPAVNLTKTVLPSFWDAEVAAVGPGMNDAAGGQLGGRAFFVQSWTVTNDHALSQKQAKALLQSYHSLNRTDLIGSGFLDLWGGISRDIADADTAFAHGKNLWLIRVDGQLVSGIWPSDGNTHMQALMKPFESALKKSAPLRSFVNYVNSELSVKEWSSRLYGSKNFAKLRKMKAAFDPEGMFSGYGLAIPAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CCI5</accession>
    <name>A0A177CCI5_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CC84DRAFT_1246391</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG04420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034785.1">
        <property type="nucleotide sequence ID" value="XM_018184202.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CCI5"/>
    <dbReference type="STRING" id="1460663.A0A177CCI5"/>
    <dbReference type="GeneID" id="28767688"/>
    <dbReference type="InParanoid" id="A0A177CCI5"/>
    <dbReference type="OrthoDB" id="310217at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050660">
        <property type="entry name" value="NEK_Ser/Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43671">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE NEK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43671:SF98">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE NEK11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="7"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAG04420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="208" mass="22965" checksum="D0050521BEC92793" modified="2016-09-07" version="1">MPSRTSFTELRHLTAGQDGGFNQGILIVRHRRTGTCYIEKRVSPRAIRTGHAAREARALRSCHHPHIISFVFADIDAAGYGYGSIYMSYCELGSLDGLLSRLARRSNFPPEGFLWKILFDMATALCYLQTGLKSSSLAQSGQPVSGCALGWVQILHRDIKPANIFVTFAHSRTESVYLALVLGDRSRSLSLRLRNPVIATPATCTPSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CCP3</accession>
    <name>A0A177CCP3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NTF2-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1164934</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG04480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034845.1">
        <property type="nucleotide sequence ID" value="XM_018178605.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CCP3"/>
    <dbReference type="GeneID" id="28762091"/>
    <dbReference type="InParanoid" id="A0A177CCP3"/>
    <dbReference type="OrthoDB" id="3732441at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41252">
        <property type="entry name" value="BLR2505 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41252:SF1">
        <property type="entry name" value="BLR2505 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12680">
        <property type="entry name" value="SnoaL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="1">
        <location>
            <begin position="11"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG04480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="140" mass="15962" checksum="E7B9D38393A13DF7" modified="2016-09-07" version="1">MARPSNLEIVQNLYLANDNADSEAFYRDLSPTITWKESDGFPTPGVFRSRADIDRHVFNVLRQEWDGFRFSLEYLVDGNERIVAVGTYRGTHRKTGRSFEARASHVWHLLDGKIESFEQFADTYTMQIAALSPVDSVSVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CCQ6</accession>
    <name>A0A177CCQ6_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Eukaryotic translation initiation factor 4C</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_1165435</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eIF-1A family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG05106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035471.1">
        <property type="nucleotide sequence ID" value="XM_018178714.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CCQ6"/>
    <dbReference type="FunCoup" id="A0A177CCQ6">
        <property type="interactions" value="766"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CCQ6"/>
    <dbReference type="GeneID" id="28762200"/>
    <dbReference type="InParanoid" id="A0A177CCQ6"/>
    <dbReference type="OrthoDB" id="274995at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd05793">
        <property type="entry name" value="S1_IF1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006196">
        <property type="entry name" value="RNA-binding_domain_S1_IF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001253">
        <property type="entry name" value="TIF_eIF-1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018104">
        <property type="entry name" value="TIF_eIF-1A_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21668">
        <property type="entry name" value="EIF-1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01176">
        <property type="entry name" value="eIF-1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00652">
        <property type="entry name" value="eIF1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01262">
        <property type="entry name" value="IF1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50832">
        <property type="entry name" value="S1_IF1_TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5 8" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S1-like" evidence="7">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="66"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="92"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="106"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00032507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAG05106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="116" mass="13144" checksum="72FB57A31FAC2F9C" modified="2016-09-07" version="1">MLGNGRLEAQCFDGTRRLGHIRGKLRKKVWINQGDIILLSLRDYQDEKGDVILKYSADEARSLKAYGELPENAKINETDTYGDQGDEGIGFEFDEDRDDSDDSDDKDGKELDIDDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CDI9</accession>
    <name>A0A177CDI9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1176939</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG04770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035135.1">
        <property type="nucleotide sequence ID" value="XM_018180253.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CDI9"/>
    <dbReference type="GeneID" id="28763739"/>
    <dbReference type="InParanoid" id="A0A177CDI9"/>
    <dbReference type="OrthoDB" id="10468716at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG04770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="618" mass="69636" checksum="D77FD13586443359" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CDX2</accession>
    <name>A0A177CDX2_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">acetylornithine transaminase</fullName>
            <ecNumber evidence="5">2.6.1.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CC84DRAFT_811029</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 4/4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.11" evidence="5"/>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG04978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035343.1">
        <property type="nucleotide sequence ID" value="XM_018187519.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CDX2"/>
    <dbReference type="FunCoup" id="A0A177CDX2">
        <property type="interactions" value="260"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CDX2"/>
    <dbReference type="GeneID" id="28771005"/>
    <dbReference type="InParanoid" id="A0A177CDX2"/>
    <dbReference type="OrthoDB" id="5419315at2759"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00109"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003992">
        <property type="term" value="F:N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:L-arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000004">
        <property type="entry name" value="Acetylornithine aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01107">
        <property type="entry name" value="ArgD_aminotrans_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004636">
        <property type="entry name" value="AcOrn/SuccOrn_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049704">
        <property type="entry name" value="Aminotrans_3_PPA_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050103">
        <property type="entry name" value="Class-III_PLP-dep_AT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00707">
        <property type="entry name" value="argD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002325">
        <property type="entry name" value="PRK01278.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11986:SF79">
        <property type="entry name" value="ACETYLORNITHINE AMINOTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11986">
        <property type="entry name" value="AMINOTRANSFERASE CLASS III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 11" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="9 10" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OAG04978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="487" mass="52343" checksum="2B4DA96B724D014B" modified="2016-09-07" version="1">MSVMALRFSTKRFATTLRASRANCGPARYASTAAALKGSSLPQDVKDSIEREASLPTPDPPSTSKTAGLVNQQLPYMVPTYVRPPPMFEKGEGCYLYDVENRKYLDFTSGIAVNALGHCDPGVTQAISEQAQLLMHTSNLYHNPLTGLLSKQLIQLTHATGGFATATKTFICNSGSEANEAAIKFARKVGKEVAPGKDKYDIVSFTGSFHGRTMGSLSATPNPKYQKPFAPMVPGFRYGTFNDVDAVNDLVTEGTCGVIVEPIQGEGGVNVATPEFLLALRKRCTEVGAVLIYDEIQCGLGRTGTFWAHASYPKEAHPDIVTTAKALGNGFPIGATIVNDFVCDHIKIGDHGTTFGGNPLGCRVASHILSRLSSPEILDSIPAKSAAFKKHFALLQERFPDRVKEIRGQGLILGLQLDEDPTPIVTAARERGLLIITCGTNTLRFVPPLVITEAEIDAGMTIVAEAMESVWTKGEQVPGTPGQQEMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CDY4</accession>
    <name>A0A177CDY4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF7136 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1177228</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG05132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035497.1">
        <property type="nucleotide sequence ID" value="XM_018180275.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CDY4"/>
    <dbReference type="GeneID" id="28763761"/>
    <dbReference type="InParanoid" id="A0A177CDY4"/>
    <dbReference type="OrthoDB" id="4490227at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055560">
        <property type="entry name" value="DUF7136"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23584">
        <property type="entry name" value="DUF7136"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7136" evidence="1">
        <location>
            <begin position="28"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF23584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG05132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="291" mass="31915" checksum="BCED87B102104CC7" modified="2016-09-07" version="1">MGQTTTTTAASTIFNATMPTPVEGRPSLEIDVFPRANTTYNYTEYLPVVFAFQNMNATLALGNVYFQWAIMPYGTEDDWILGGIWIEDPGYSGLETHNVPDFFNPDGSPYFMVNSTNTTNWNTNSVPSNWPGEEFLYSLRWYLRWSAFGYAREDETCVYLHGDLKGDMFFTMHHTRSSGGYWQGDSTTYPNPRELGNVTGNCAQFGGMREINVNSTDLCEKARVVSSGNPCTVKPDAALVSSMSSVAALRAQPTPTRIEEPSSSSAARAMSMPGRAVLVLAGIIGGPALPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CE57</accession>
    <name>A0A177CE57_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CC84DRAFT_1145105</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG05596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035961.1">
        <property type="nucleotide sequence ID" value="XM_018176493.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CE57"/>
    <dbReference type="STRING" id="1460663.A0A177CE57"/>
    <dbReference type="GeneID" id="28759979"/>
    <dbReference type="InParanoid" id="A0A177CE57"/>
    <dbReference type="OrthoDB" id="448448at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18008">
        <property type="entry name" value="DEXDc_SHPRH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050628">
        <property type="entry name" value="SNF2_RAD54_helicase_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626:SF52">
        <property type="entry name" value="SINGLE-STRANDED DNA-DEPENDENT ATPASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="242"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="8">
        <location>
            <begin position="575"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="657"/>
            <end position="804"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OAG05596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="804" mass="91652" checksum="F4468B0870B72C6B" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CEJ9</accession>
    <name>A0A177CEJ9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1259120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG05736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036101.1">
        <property type="nucleotide sequence ID" value="XM_018184885.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CEJ9"/>
    <dbReference type="GeneID" id="28768371"/>
    <dbReference type="InParanoid" id="A0A177CEJ9"/>
    <dbReference type="OrthoDB" id="5138733at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="205"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="289"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="352"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="358"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG05736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="590" mass="65455" checksum="A5B713AE834BB256" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CEX3</accession>
    <name>A0A177CEX3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Carbonyl reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CC84DRAFT_1165575</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG05280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035645.1">
        <property type="nucleotide sequence ID" value="XM_018178749.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CEX3"/>
    <dbReference type="STRING" id="1460663.A0A177CEX3"/>
    <dbReference type="GeneID" id="28762235"/>
    <dbReference type="InParanoid" id="A0A177CEX3"/>
    <dbReference type="OrthoDB" id="1933717at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43963">
        <property type="entry name" value="CARBONYL REDUCTASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43963:SF6">
        <property type="entry name" value="CHAIN DEHYDROGENASE FAMILY PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G15350)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAG05280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="288" mass="31034" checksum="82F4871AEFBFEEDA" modified="2016-09-07" version="1">MTYNRVGVVTGANKGIGLAIVRQLALQYPKSPLNSGSFLIYLTARDRGRGEAALEDLRNDAQLKQAQALKSDSGQTEIQYHQLDITDQKSLETFAAHIKQMHGDGIDFIINNAGIAMNGFNAELAKITLGCNYYNTMEVCHTFVPLLKPQGRIVNLASMAGHLSKYSDDVRKRFLAAKTEGDISGIMKDFISAVEAGNEKEAGYPSAAYAVSKAGLIGASKALSRAEQEKGSKILVNACCPGYVNTDMTKGNGTKSPDEGAQTPVLLALADIKGATGEFWQNEKPIEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CFB4</accession>
    <name>A0A177CFB4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phospholipase D/nuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1090988</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG06304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036669.1">
        <property type="nucleotide sequence ID" value="XM_018174382.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CFB4"/>
    <dbReference type="STRING" id="1460663.A0A177CFB4"/>
    <dbReference type="GeneID" id="28757868"/>
    <dbReference type="InParanoid" id="A0A177CFB4"/>
    <dbReference type="OrthoDB" id="2958217at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030572">
        <property type="term" value="F:phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032049">
        <property type="term" value="P:cardiolipin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00138">
        <property type="entry name" value="PLDc_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.870.10">
        <property type="entry name" value="Endonuclease Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025202">
        <property type="entry name" value="PLD-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21248">
        <property type="entry name" value="CARDIOLIPIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21248:SF11">
        <property type="entry name" value="PLD PHOSPHODIESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13091">
        <property type="entry name" value="PLDc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00155">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56024">
        <property type="entry name" value="Phospholipase D/nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PLD phosphodiesterase" evidence="1">
        <location>
            <begin position="167"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="PLD phosphodiesterase" evidence="1">
        <location>
            <begin position="425"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG06304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="506" mass="55981" checksum="586A4A44873B432D" modified="2016-09-07" version="1">MPSLGPLPSPLPFTEPFVGSLKKAAPFNHQDDPNWYAHDPQCLISESAVNSFVTGTGDAIYRSLAPLLEATNHELILVTCFWARSSSLDSLNALLRKLSEKAISRGTGKIKVRLCFSSSSLFQKLFHTQSTQGQTYPSSSWTKQFGLPEPSELEGLDLRISSIFILPFSVMHPKFILIDRRSVVLPSCNISWEEWFEGAITFSGPIVENFFQFYKRFWCRMDVQSLPTSTIHSDYPSPQHVNTAAPQDLRDIVPHGHTITPISTTSSTIPTIFLPSPHRRNPNFHPFASSSAISAPPTPLNVFVLNLLAQAARTIRIQSPNLTSPPVLSAILKSLGRGVDVQILTSERLMILEQLVTAGTTTSRCVKTLIKRYKKLARAEAAHLATDEEAALSAPRMGVLKILYFEPLHGSKPRGKEEGEPQQSHLKMMIVDGEVVVLGSGNLDRASWFTSQELGVAFFDKGLVGQVEEAVDRGMKGRAKLVFDGSRLVERPKQWTCMATSRNRSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CH50</accession>
    <name>A0A177CH50_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_630390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG06894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037259.1">
        <property type="nucleotide sequence ID" value="XM_018186943.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CH50"/>
    <dbReference type="GeneID" id="28770429"/>
    <dbReference type="InParanoid" id="A0A177CH50"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG06894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="296" mass="32171" checksum="37739AA6F89CBFD0" modified="2016-09-07" version="1">MLVESALGVVSNVQLRVLPDVYLVCAVCSFRITQSTGSLGVANLTRLQVHRAGAAPFKTANNLLRNSQMSSKNSVRTGHSCSNYATLRRFRVSRGVRKTVARRADAQGRASEGGYNLGAVAHAPVLVSTVLRRPRTGSSKGLLAQRSKGHLGDNLVVGWARPDLLTLLSDKFKRGLGLIYGVRPNTTLRNEKRRSPGQGRKARGSGALPSSRALALRGRVERSQRKRPSTTHRRDAGGVTRRESSASDWVSVLSLAIGFSHNIMRLPTIKSNSHLESPLFLVGGDQTTQSQLRYDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CHH6</accession>
    <name>A0A177CHH6_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Integral membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CC84DRAFT_760451</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM234 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG06308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036673.1">
        <property type="nucleotide sequence ID" value="XM_018187329.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CHH6"/>
    <dbReference type="GeneID" id="28770815"/>
    <dbReference type="InParanoid" id="A0A177CHH6"/>
    <dbReference type="OrthoDB" id="43458at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3730.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018908">
        <property type="entry name" value="TMEM234"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28668">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 234"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28668:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 234"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10639">
        <property type="entry name" value="TMEM234"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="15"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="91"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="132"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAG06308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="152" mass="16916" checksum="8FB73666C4AA99BD" modified="2016-09-07" version="1">MDRDTPTTPAPQPSVWRWILGFLMVGACWGLTTPFMRRAALNYTPPARPSLTDPNNSWLKRKALGIWYAVIGTLSRPAYAVPFLLNVTGSIWFFILIGQAELSLTVPITNSLAFLFTVLGEWWAEKKIISRDTWIGMGFVLAGIALCVQAKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CI46</accession>
    <name>A0A177CI46_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1163401</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG07175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037540.1">
        <property type="nucleotide sequence ID" value="XM_018178256.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CI46"/>
    <dbReference type="GeneID" id="28761742"/>
    <dbReference type="InParanoid" id="A0A177CI46"/>
    <dbReference type="OrthoDB" id="5304367at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="41"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="17"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG07175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="146" mass="16238" checksum="A4135DB17615ADFE" modified="2016-09-07" version="1">MGGRLSMPRGADGMSETSKPTSSPTPARLTRSRGIINGRTVMAPLAALTMAGLLFVYARTSIRAAKLNAQKHREADGGQISWHKESMRRHGQLERVGSDRSTLKEALQADFTRSKKEKLTSSEEPKVRTERSPEEKRLRKMMGKDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CIA8</accession>
    <name>A0A177CIA8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Mannan polymeras-like protein II complex ANP1 subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_1143635</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the ANP1/MMN9/VAN1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG07243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037608.1">
        <property type="nucleotide sequence ID" value="XM_018176423.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CIA8"/>
    <dbReference type="STRING" id="1460663.A0A177CIA8"/>
    <dbReference type="GeneID" id="28759909"/>
    <dbReference type="InParanoid" id="A0A177CIA8"/>
    <dbReference type="OrthoDB" id="204164at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000136">
        <property type="term" value="C:mannan polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000009">
        <property type="term" value="F:alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000032">
        <property type="term" value="P:cell wall mannoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000017">
        <property type="entry name" value="Mannan polymerase II complex ANP1 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052086">
        <property type="entry name" value="Mannan_Polymerase_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43083">
        <property type="entry name" value="MANNAN POLYMERASE II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43083:SF4">
        <property type="entry name" value="N-GLYCOSYL-TRANSFERASE (AFU_ORTHOLOGUE AFUA_4G06870)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03452">
        <property type="entry name" value="Anp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAG07243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="410" mass="46978" checksum="5C4029D3C946B2D0" modified="2016-09-07" version="1">MLMPKSYSWKAARARLPPSRQVLHTLRSPRTWALFGVVAVLALLWRSMGSAAGEMQRFYCWGPAKSPLHMTANENEEWYRHRQTPVIFNPHKSIAINDSSINYVNLNEIQSTVDAVKKRERVLILTPIREASKHLPQHFDLLSSLTYPHELIDLAFLVGDSEDDTMAALAKELERVQGNPEVAFHSTMIVEKDFGVTLSQEVHDRHSFEAQGPRRKALARARNYLLATALRPEHSWVYWRDVDIHDSPPEIIEDFILHDRDILVPNVWFHRYREVNGKMVDIEGRFDYNSWQETPESLKVVANVEKDKDLVLAEGYKNLKIFGLRNHMALQGDWREDKDAEIPLDGIGGVNIIVKADVHRSGINFPCYAFENQAETEGFAKMAKRAGYGVYGLPNYVVWHVDTDERPGNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CIE7</accession>
    <name>A0A177CIE7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">p-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1143733</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG07294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037659.1">
        <property type="nucleotide sequence ID" value="XM_018176428.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CIE7"/>
    <dbReference type="FunCoup" id="A0A177CIE7">
        <property type="interactions" value="6"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CIE7"/>
    <dbReference type="GeneID" id="28759914"/>
    <dbReference type="InParanoid" id="A0A177CIE7"/>
    <dbReference type="OrthoDB" id="6362633at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10285">
        <property type="entry name" value="URIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG07294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="240" mass="27028" checksum="CB80231941CE1AB2" modified="2016-09-07" version="1">MEEQVDRLVKKTWESYQNVPPSKRLLIAVSGIPGSGKTTLAAIVSNRLNELHAQQSPGTYSSNPLSAFLPMDGYHLSRRQLDALPDPVSAHARRGAEFTFDGESFLKLVKKLREPLCPETQTLFAPSFDHAMKDPVVDDIAIAPSIRIIIFEGNYLSLDKPPWKDAAAMMHELWFVDVDREVARKRLIYRHVRAGIADTEESAARRADENDLVNGKEIIENRLDVHEIVTSKDDDGWKPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CJD0</accession>
    <name>A0A177CJD0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Flavo protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_1088764</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the HFCD (homooligomeric flavin containing Cys decarboxylase) superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG07603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037968.1">
        <property type="nucleotide sequence ID" value="XM_018174271.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CJD0"/>
    <dbReference type="STRING" id="1460663.A0A177CJD0"/>
    <dbReference type="GeneID" id="28757757"/>
    <dbReference type="InParanoid" id="A0A177CJD0"/>
    <dbReference type="OrthoDB" id="1532798at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071513">
        <property type="term" value="C:phosphopantothenoylcysteine decarboxylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004633">
        <property type="term" value="F:phosphopantothenoylcysteine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1950">
        <property type="entry name" value="Flavin prenyltransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036551">
        <property type="entry name" value="Flavin_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003382">
        <property type="entry name" value="Flavoprotein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14359">
        <property type="entry name" value="HOMO-OLIGOMERIC FLAVIN CONTAINING CYS DECARBOXYLASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14359:SF6">
        <property type="entry name" value="PHOSPHOPANTOTHENOYLCYSTEINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02441">
        <property type="entry name" value="Flavoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52507">
        <property type="entry name" value="Homo-oligomeric flavin-containing Cys decarboxylases, HFCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavoprotein" evidence="3">
        <location>
            <begin position="39"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAG07603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="262" mass="29416" checksum="8D5AFC9DB8765F29" modified="2016-09-07" version="1">MAAIIENLKPLHLKPVRSPESAVVNMDPYALPLEDSKIHLLLCATGSVATIKIPNMVQALSRYTNLSIRLIFTEAAKNFLRGQSAEQPSIEEIKALPNVDAVYFDEDEWSEPWVRGNKILHIELRRWADIMVIAPLSADSLAKITQGWSDNLLLSVVRAWDTTGELDPIRNLGGVNGHIDETRRKKRILVAPSMNTAMWKQPITKKQVDILDEEWGVKNGGWFEVLLPMEKQLACGDVGGGAMKDWREIVEVIEDRLRMNGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CJX1</accession>
    <name>A0A177CJX1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">D-xylose 1-dehydrogenase (NADP(+), D-xylono-1,5-lactone-forming)</fullName>
            <ecNumber evidence="3">1.1.1.179</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">D-xylose-NADP dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_1203372</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>D-xylose + NADP(+) = D-xylono-1,5-lactone + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22000"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15867"/>
            <dbReference type="ChEBI" id="CHEBI:53455"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.179"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfo/Idh/MocA family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.179" evidence="3"/>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG07824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038189.1">
        <property type="nucleotide sequence ID" value="XM_018181823.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CJX1"/>
    <dbReference type="STRING" id="1460663.A0A177CJX1"/>
    <dbReference type="GeneID" id="28765309"/>
    <dbReference type="InParanoid" id="A0A177CJX1"/>
    <dbReference type="OrthoDB" id="6417021at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047837">
        <property type="term" value="F:D-xylose 1-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050984">
        <property type="entry name" value="Gfo/Idh/MocA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055170">
        <property type="entry name" value="GFO_IDH_MocA-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22604">
        <property type="entry name" value="OXIDOREDUCTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22604:SF105">
        <property type="entry name" value="TRANS-1,2-DIHYDROBENZENE-1,2-DIOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22725">
        <property type="entry name" value="GFO_IDH_MocA_C3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="6">
        <location>
            <begin position="25"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="GFO/IDH/MocA-like oxidoreductase" evidence="7">
        <location>
            <begin position="168"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00042988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF22725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAG07824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="411" mass="46955" checksum="E95ACCFBE7570ACC" modified="2016-09-07" version="1">MSLAQLKRIYTAFNPPAVEKRGDALKFGIIGAANSAAWALLIPAKMHPEVVVHAIAARDRKRAEEFAKKNGVPVVYDSYQELLDDPEIDCILVPLPNSLHFEWAVKSIRAGKHVLLEKPSVSNSHEAEILFNLPELNQPKAPVILEAFHYRFHPIWSAFMSNVTSADVVHVDTYSMIPWWFVNKDHIHFNYNLAGGTMMGMGTYNFAALRLIFGAEPEECISVDVKALTEGVHHDCDTEFKAKFRFPNGCIGEAFSTLQGPTIWHPSYARVTHRQVEVEDKTLPSSQKKFVTREVTLHGFIHAIFWHRLDIKESYEIRDKDTGRVVKKWTESRWQKAHTAKEAGVDLGKTESETYWMSFRYQLEAFVNRVKGRETAYWVDREDSVRQMKMVDMAYQKSGLGVRPTSKFQAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CKE0</accession>
    <name>A0A177CKE0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Regulator of G protein signaling superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_654238</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG07309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037674.1">
        <property type="nucleotide sequence ID" value="XM_018187013.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CKE0"/>
    <dbReference type="GeneID" id="28770499"/>
    <dbReference type="InParanoid" id="A0A177CKE0"/>
    <dbReference type="OrthoDB" id="10266999at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07440">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016137">
        <property type="entry name" value="RGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10845">
        <property type="entry name" value="REGULATOR OF G PROTEIN SIGNALING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10845:SF267">
        <property type="entry name" value="REGULATOR OF G PROTEIN SIGNALING DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G06860)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00615">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00315">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50132">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RGS" evidence="2">
        <location>
            <begin position="84"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="209"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="263"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="15"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="275"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="333"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG07309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="390" mass="42715" checksum="72C785BDDA74B748" modified="2016-09-07" version="1">MNSRKTATQPLQIRTPSSTASSPTTSTVEPDDEDVKMSMAEYHQPSRPLTVSIPRSIASASNRRPNLSEILANTAPPPYTLSSFMAFLSQNHCLENLEFTMDASRYRKHYSKMVNRHPGTPISPLSDECAYVLMLWRRLIDAYIRESGPREVNLPADVRDTLLNLSDSYVPPHPSALDEAVSKIYELMEESVLVSFLNSASPMSALASAVSHDSHESSTTRSSTRSYDERTLYHPRTSAHPPVHQRASAPSSLTSNFMHARPFSHSRFNSQPATSSGSPSSRGPLSYASGSDALTDDSGSRSPSGMSDPLTPPGTPPMSDYPMTDFQQAYYDNGSNSGTPSPRTSRGEHSGLANATRDSWKRVSSKLWPKKRSGGQLREEEQGVVEGGLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CKW8</accession>
    <name>A0A177CKW8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1258571</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG07479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037844.1">
        <property type="nucleotide sequence ID" value="XM_018184839.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CKW8"/>
    <dbReference type="STRING" id="1460663.A0A177CKW8"/>
    <dbReference type="GeneID" id="28768325"/>
    <dbReference type="InParanoid" id="A0A177CKW8"/>
    <dbReference type="OrthoDB" id="73875at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053214">
        <property type="entry name" value="LysM12-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47700:SF2">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47700">
        <property type="entry name" value="V CHITINASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G13720)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0843">Virulence</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG07479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="224" mass="25253" checksum="A1AE6B5D377F6CEE" modified="2016-09-07" version="1">MDYLKFLILLKQKMGAKSVSIAASASYWYLKAFPIDRIAKAINYIVYMTKSFWLLIAVFLANNSISSTDMTFMDGGIDSTGQLMRLLPALKDRGAGSMWKRVCFKPSIDKFDENDFRDNMGRDPWIRTQVTSLVTGKKKPRTTKTVTITEFSATVSILSQLSIARYLPVPQNNMDDGQSENKCWPSAIAPLDPGFALLEVDPYYEGMRPPYDYAQPYDPPNNGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CLC6</accession>
    <name>A0A177CLC6_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1216524</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG07587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037952.1">
        <property type="nucleotide sequence ID" value="XM_018182813.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CLC6"/>
    <dbReference type="STRING" id="1460663.A0A177CLC6"/>
    <dbReference type="GeneID" id="28766299"/>
    <dbReference type="InParanoid" id="A0A177CLC6"/>
    <dbReference type="OrthoDB" id="3918601at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39614">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39614:SF2">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="217"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="249"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="2">
        <location>
            <begin position="51"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG07587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="368" mass="40116" checksum="6630D3368F32D05D" modified="2016-09-07" version="1">MSDPSAAGPTIDPMDTSAGNRFAPYSPENHSAPLWIVSILGLIYTIGVLSIRLFIKRRVFGWDDSLIVAGTLTGLVQAIVFFKALKSGLGQVPEHVPNLSTTASLAFTAQILLLIALYLAKCSGILLLRRLFVRDQQNTGRLCDVVLGFTVVCGIATVVMSSAGCPSTGSFTTHCSSTNTRWSVVTALDIATEVILLLLPAYLVWQLQMKTSYKLRVIAAFCFRILVIIFSIFHLIARIKYADTQPSPFNIVTTLVWHQTLLAWGLISATIPNLKAFLQSLSASWGGADWGYTVKAYGNGTFEMKSMGTQSRSHAMASTTGTENATDMDQKYETQIQTRQVGERSSLGSGGSQDMIIRKETVWTVVRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CLI2</accession>
    <name>A0A177CLI2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1173866</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038738.1">
        <property type="nucleotide sequence ID" value="XM_018180062.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CLI2"/>
    <dbReference type="GeneID" id="28763548"/>
    <dbReference type="InParanoid" id="A0A177CLI2"/>
    <dbReference type="OrthoDB" id="3800944at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="301"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG08373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="619" mass="66420" checksum="D7630B590DD565E6" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CMF8</accession>
    <name>A0A177CMF8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Streptomycin biosynthesis protein StrI</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1085549</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038415.1">
        <property type="nucleotide sequence ID" value="XM_018174107.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CMF8"/>
    <dbReference type="STRING" id="1460663.A0A177CMF8"/>
    <dbReference type="GeneID" id="28757593"/>
    <dbReference type="InParanoid" id="A0A177CMF8"/>
    <dbReference type="OrthoDB" id="2129491at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051450">
        <property type="entry name" value="Gfo/Idh/MocA_Oxidoreductases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43377">
        <property type="entry name" value="BILIVERDIN REDUCTASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43377:SF12">
        <property type="entry name" value="BINDING ROSSMANN FOLD OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G11840)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="1">
        <location>
            <begin position="33"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG08050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="547" mass="61039" checksum="8A80232A41D6670E" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CMM3</accession>
    <name>A0A177CMM3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">pectinesterase</fullName>
            <ecNumber evidence="3">3.1.1.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_536334</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Glycan metabolism; pectin degradation; 2-dehydro-3-deoxy-D-gluconate from pectin: step 1/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the pectinesterase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.11" evidence="3"/>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038424.1">
        <property type="nucleotide sequence ID" value="XM_018186655.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CMM3"/>
    <dbReference type="STRING" id="1460663.A0A177CMM3"/>
    <dbReference type="GeneID" id="28770141"/>
    <dbReference type="InParanoid" id="A0A177CMM3"/>
    <dbReference type="OrthoDB" id="2019149at2759"/>
    <dbReference type="UniPathway" id="UPA00545">
        <property type="reaction ID" value="UER00823"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030599">
        <property type="term" value="F:pectinesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042545">
        <property type="term" value="P:cell wall modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045490">
        <property type="term" value="P:pectin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000070">
        <property type="entry name" value="Pectinesterase_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31321">
        <property type="entry name" value="ACYL-COA THIOESTER HYDROLASE YBHC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31321:SF137">
        <property type="entry name" value="PECTIN METHYL ESTERASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01095">
        <property type="entry name" value="Pectinesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0063">Aspartyl esterase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011117790" description="pectinesterase" evidence="6">
        <location>
            <begin position="26"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="Pectinesterase catalytic" evidence="7">
        <location>
            <begin position="176"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAG08059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="402" mass="43838" checksum="8764857103785DDE" modified="2016-09-07" version="1">MPSISTSLSWLSVFGLLFSPQSCLALSKKDRLACQRATHDPLKGCPKHTLLVDAESANATAKKNVFSSIQSAVLSLPHDNSTQYILILPGQYTEQVNVTRPGPLYLLGQTSDAASLAKNTVEVVWHNATGTATTGSYDNAWTSTLTIAPTFNSSTTGAGPTGNHVPDDTPFGNFDFRAYNLNFTNDYLPYSAGPSLALSTSYANTGFYHCSFKSYQDTIYVGKLANSYMSKCEIAGQTDFLYGFGTLWIEDSDLLMRSCGGGITAWKGTNTTYENKFGVYIHQSNVVAANSSIAPAMVGKCALGRPWNAQHRSIFANTYLDASIKPSGYIAWGTTDPRVNNYTLMAEYKTYGPGWNQTGRIDGNVTHILTEKQWQPYSSPSKVFQFFKSGKTGNSAWVDWNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2023-06-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CN95</accession>
    <name>A0A177CN95_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_585002</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039046.1">
        <property type="nucleotide sequence ID" value="XM_018186780.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CN95"/>
    <dbReference type="GeneID" id="28770266"/>
    <dbReference type="InParanoid" id="A0A177CN95"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG08681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="190" mass="20210" checksum="DAEF8854B2FE7F79" modified="2016-09-07" version="1">MGFPPLLCPGPPIYPRVHCIPVFPSRGSEASRHLSSAVGATGLRRRTAEGRHRVSAPHSTCAESGLEGGKLGLGRRVRCVQSVSGRRLHLSESAPPWERGRANACTRGPCVAVDPVVAWLPSGRRRRVGPKGCSAEADRGVRLWHCGVTVALCGITITVGLMMMGAGLECIHRRGFASLRSVHRRGGGLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CNW4</accession>
    <name>A0A177CNW4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Endoplasmic reticulum lectin</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Protein OS-9 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CC84DRAFT_1215151</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Lectin involved in the quality control of the secretory pathway. As a member of the endoplasmic reticulum-associated degradation lumenal (ERAD-L) surveillance system, targets misfolded endoplasmic reticulum lumenal glycoproteins for degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Endoplasmic reticulum membrane</location>
            <topology evidence="1 7">Peripheral membrane protein</topology>
            <orientation evidence="1 7">Lumenal side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the OS-9 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039037.1">
        <property type="nucleotide sequence ID" value="XM_018182698.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CNW4"/>
    <dbReference type="STRING" id="1460663.A0A177CNW4"/>
    <dbReference type="GeneID" id="28766184"/>
    <dbReference type="InParanoid" id="A0A177CNW4"/>
    <dbReference type="OrthoDB" id="448954at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030968">
        <property type="term" value="P:endoplasmic reticulum unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030970">
        <property type="term" value="P:retrograde protein transport, ER to cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.130.10">
        <property type="entry name" value="Mannose-6-phosphate receptor binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009011">
        <property type="entry name" value="Man6P_isomerase_rcpt-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044865">
        <property type="entry name" value="MRH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045149">
        <property type="entry name" value="OS-9-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012913">
        <property type="entry name" value="OS9-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15414:SF0">
        <property type="entry name" value="ENDOPLASMIC RETICULUM LECTIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15414">
        <property type="entry name" value="OS-9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07915">
        <property type="entry name" value="PRKCSH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50911">
        <property type="entry name" value="Mannose 6-phosphate receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51914">
        <property type="entry name" value="MRH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 7" id="KW-0430">Lectin</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008058441" description="Endoplasmic reticulum lectin" evidence="9">
        <location>
            <begin position="17"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="domain" description="MRH" evidence="10">
        <location>
            <begin position="149"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="60"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="203"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="473"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="490"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU369099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OAG08672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="533" mass="58532" checksum="D1CADF6D88881058" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CPJ2</accession>
    <name>A0A177CPJ2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1162909</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG09141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039506.1">
        <property type="nucleotide sequence ID" value="XM_018178121.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CPJ2"/>
    <dbReference type="GeneID" id="28761607"/>
    <dbReference type="InParanoid" id="A0A177CPJ2"/>
    <dbReference type="OrthoDB" id="5377226at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG09141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="225" mass="25294" checksum="F68C98ED7DAF0824" modified="2016-09-07" version="1">MVYITPGLFGHDHKHTPSVFSSSTHAHVQNHMVDSQIAASLGKRKRRLEDDKDMPSPKHISMSSADVDRYGSSISRTSPTSEGHIRLYGHDPASHEATVPRTFSRSPKLASSERRPVKQMKRLHVKTPSHLMDTEPDLVPSSPPVQRVDSHTKSDLSPCHVCSTAPKRKRDLEGYMDCQRCTERTCYICARECLGCQKAICKECIVEIGQDGEPWCLECYQHINT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CPP8</accession>
    <name>A0A177CPP8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1235008</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG09493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039858.1">
        <property type="nucleotide sequence ID" value="XM_018183836.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CPP8"/>
    <dbReference type="GeneID" id="28767322"/>
    <dbReference type="InParanoid" id="A0A177CPP8"/>
    <dbReference type="OrthoDB" id="10422528at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="29"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="171"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="63"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG09493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="365" mass="40452" checksum="3FE0005F3023CA64" modified="2016-09-07" version="1">MAPPASDATQQRSSRFTIRKLFSCQKRLTPKVLEDAEKQTPTTEGSLSAPDHQQFRAGPEYATTVSESREQTLSTGASRPGAVATKELSSRRPANARNGARLLFRRKQADALKDAKVEPRKTAMVRKKEFPPSIGTHSSGLSLGKMIRSGISDDTKRLLKDAFEDFWEFKREQERNRIREEEKQEEIARVEEVMDVVETKVVRKGSTIRHVKVMRPAVRLEKGVSLDPNQRLASMNITDGRNRAGVSSCSSIAGSQAAETGPSSTTPVISGSIMDRGPGFKRRRLSNHFGVQPCKPSEKKCDSFDGPSNSIRLDFALLMCDGNLVIAGWNTSHLPSLNMVLIIHFEHFVQLSKETVISGDVDWCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CQ41</accession>
    <name>A0A177CQ41_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fungal N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1257630</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039232.1">
        <property type="nucleotide sequence ID" value="XM_018184751.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CQ41"/>
    <dbReference type="STRING" id="1460663.A0A177CQ41"/>
    <dbReference type="GeneID" id="28768237"/>
    <dbReference type="InParanoid" id="A0A177CQ41"/>
    <dbReference type="OrthoDB" id="10265068at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.30">
        <property type="entry name" value="Hypothetical protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="DNA-glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG08867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="428" mass="47920" checksum="A8DECAA6A93EBCCE" modified="2016-09-07" version="1">MEAAAAVVSFVGLAGPVAQGLKFLYDFTTDMKDCPKDIREMKTDLELVEALITNVIKQCNERDLQLRESVALAKAIARAQESVQDLKEALAMYMMNGKHRRFKFAAKLSQTQKLRTSLDRTKTIMFELKNQLQSDIVYDIRDTNQKILRTVEKTNKDLETHDRSVHHVAQRLQNQARTTNRTMDTIGQSVQQASDNSSEELTNIKLVEKQLERITDLLEGTTISPSPSSTTSTPALSREVSDFSVISSQETIATSIASSPSISRSVSQNPQPVDSISEHPLLQFRDNQFHFLVACIFTQRSRNQRLACQRASECLAAYPTPIALAKASEQALSQYFGGIGLQNMKPPRLIALAQAYVRDPPKAGVNRSKTKKGSCPESEITHLPWIGEQSVNTWWVYCCERTDVATKEKPLLEYIEHLKDRNGGAPFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CQK0</accession>
    <name>A0A177CQK0_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein BCP1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CC84DRAFT_1193471</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 3">Involved in nuclear export, actin cytoskeleton organization and vesicular transport.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the BCP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG09794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040159.1">
        <property type="nucleotide sequence ID" value="XM_018181301.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CQK0"/>
    <dbReference type="FunCoup" id="A0A177CQK0">
        <property type="interactions" value="989"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CQK0"/>
    <dbReference type="GeneID" id="28764787"/>
    <dbReference type="InParanoid" id="A0A177CQK0"/>
    <dbReference type="OrthoDB" id="27543at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025602">
        <property type="entry name" value="BCP1_family"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13261">
        <property type="entry name" value="BRCA2 AND CDKN1A INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13261:SF0">
        <property type="entry name" value="BRCA2 AND CDKN1A-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13862">
        <property type="entry name" value="BCCIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028983">
        <property type="entry name" value="BCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR028983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAG09794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="295" mass="32791" checksum="348887947F247A93" modified="2016-09-07" version="1">MAKRKSQKDPEDLPDAPEGKGKRRNDDSDSDEDMDTLDVDFEWFDPNPAVDFHGLKTLLRQLLDVDNQLFNLSELADLILSQPLLGSTVKCDGTESDPFSFLTVLNLETHKDKQVIADLTAYLTRHSTSPSLAPLNTLLTAPSTAQIGLILTERFINMPHEIVAPSYKMLQEEIQWALDEKEPYAFTHYLVLSKAYIEVESNLPAAEQPPAKKKKAAKADNRETFYFHPEDEVLHKHALGFGSFEFESPVDEGASDSKRAFQEMGVKPMGHLILIEADKFAGAVGAVESFLGGGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CQP2</accession>
    <name>A0A177CQP2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1160882</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG09825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040190.1">
        <property type="nucleotide sequence ID" value="XM_018177604.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CQP2"/>
    <dbReference type="STRING" id="1460663.A0A177CQP2"/>
    <dbReference type="GeneID" id="28761090"/>
    <dbReference type="InParanoid" id="A0A177CQP2"/>
    <dbReference type="OrthoDB" id="3769501at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021833">
        <property type="entry name" value="DUF3425"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37012">
        <property type="entry name" value="B-ZIP TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37012:SF2">
        <property type="entry name" value="BZIP DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11905">
        <property type="entry name" value="DUF3425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG09825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="238" mass="26746" checksum="B453C622329A8CFA" modified="2016-09-07" version="1">MLAGSPDFPDPETVTSRIAPAEGAENDLPYGQAVWTALPRHVPSTCALDSAILNLINIRRSHEATGGNIQEFQKAIFPSVQSLLNPPGDAVKAPLANSIVRDIVSALAVRTIPEQVAILYIMGVSIRWQISPTQYNYDAMPEWLRPTPSQIFNRHAAWLDTLAWPSARERLCRADKWEGKDVLVRRICEKTFSVNWPYEAADIFLHDKTEPSLNPVFEQHIRNGKNWTLGREIKDILI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CRW3</accession>
    <name>A0A177CRW3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">EKC/KEOPS complex subunit BUD32</fullName>
            <ecNumber evidence="7">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="25 26">Atypical Serine/threonine protein kinase BUD32</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">EKC/KEOPS complex subunit bud32</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="31" type="ORF">CC84DRAFT_1235083</name>
    </gene>
    <organism evidence="31 32">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="31 32" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="31 32">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. BUD32 has ATPase activity in the context of the EKC/KEOPS complex and likely plays a supporting role to the catalytic subunit KAE1. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. The complex is required for efficient recruitment of transcriptional coactivators.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="28">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="27">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the EKC/KEOPS complex composed of at least BUD32, CGI121, GON7, KAE1 and PCC1; the whole complex dimerizes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Chromosome</location>
            <location evidence="4">Telomere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the protein kinase superfamily. BUD32 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="7"/>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG09517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039882.1">
        <property type="nucleotide sequence ID" value="XM_018183838.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CRW3"/>
    <dbReference type="FunCoup" id="A0A177CRW3">
        <property type="interactions" value="898"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CRW3"/>
    <dbReference type="GeneID" id="28767324"/>
    <dbReference type="InParanoid" id="A0A177CRW3"/>
    <dbReference type="OrthoDB" id="3399at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000408">
        <property type="term" value="C:EKC/KEOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070525">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000603">
        <property type="entry name" value="EKC/KEOPS complex subunit bud32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000845">
        <property type="entry name" value="Probable bifunctional tRNA threonylcarbamoyladenosine biosynthesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022495">
        <property type="entry name" value="Bud32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03724">
        <property type="entry name" value="arch_bud32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12209:SF0">
        <property type="entry name" value="EKC_KEOPS COMPLEX SUBUNIT TP53RK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12209">
        <property type="entry name" value="NON-SPECIFIC SERINE/THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06293">
        <property type="entry name" value="Kdo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="22" id="KW-0010">Activator</keyword>
    <keyword evidence="19" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0158">Chromosome</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="18" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="17 31" id="KW-0418">Kinase</keyword>
    <keyword evidence="16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="24" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="32" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="20" id="KW-0779">Telomere</keyword>
    <keyword evidence="23" id="KW-0804">Transcription</keyword>
    <keyword evidence="21" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="14" id="KW-0808">Transferase</keyword>
    <keyword evidence="15" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Protein kinase" evidence="30">
        <location>
            <begin position="34"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="29">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="29">
        <location>
            <begin position="9"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00013948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00019973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00030980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00033194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="30">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="EMBL" id="OAG09517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="32">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="270" mass="29890" checksum="CF0BF6537D6F2113" modified="2016-09-07" version="1">MAPETIEPTAPPLRAPSPAPTDRPLHTLPSPFTASNLEVLTQGAEALVYKSTFLTPQTPCVVKYRPPKPYRHPVLDRRLTKARLLAEARVLVRCKRDGVDVPGVLGADWEAGWLVLEWVEGRTVRAVLDGWAERGAQEEEGVLGLMGRVGRAVGRLHGIGVVHGDLTTSNLMVRQDERREEGVKQTNELEGDIVLIDFGLASHSTQNLQDEDRAVDLYVLERAFAATHPKAEPLFQEVLNAYGESFKGARAVLKRLEDVRLRGRKRSMLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CSD1</accession>
    <name>A0A177CSD1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribosomal protein S8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_1161385</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS8 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040808.1">
        <property type="nucleotide sequence ID" value="XM_018177722.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CSD1"/>
    <dbReference type="FunCoup" id="A0A177CSD1">
        <property type="interactions" value="72"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CSD1"/>
    <dbReference type="GeneID" id="28761208"/>
    <dbReference type="InParanoid" id="A0A177CSD1"/>
    <dbReference type="OrthoDB" id="409928at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.10:FF:000005">
        <property type="entry name" value="Mitochondrial 40S ribosomal protein S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000630">
        <property type="entry name" value="Ribosomal_uS8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035987">
        <property type="entry name" value="Ribosomal_uS8_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11758">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S15A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00410">
        <property type="entry name" value="Ribosomal_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56047">
        <property type="entry name" value="Ribosomal protein S8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAG10443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="199" mass="22328" checksum="0C68BA17ACC015F9" modified="2016-09-07" version="1">MSLVNLAHVCSHLQNASKARLGLTSIPVSKMHVNLMLGLQREGFISSVTLGGTTPPTPFLLQDQLDPEEHEDMAQKLAAEPWAAYPSPKRAGEPLLGGREVSYNVKVPQNPARRRLWLGLKYWNNEPVLKTMKLISKPTRRIWLTSEDLGRITRTRESAYVKGLTHPGECMFLSTDRGILEARECVERKLGGQPLCRVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CSH8</accession>
    <name>A0A177CSH8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">6-phosphogluconate dehydrogenase C-terminal domain-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_486285</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040859.1">
        <property type="nucleotide sequence ID" value="XM_018186467.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CSH8"/>
    <dbReference type="STRING" id="1460663.A0A177CSH8"/>
    <dbReference type="GeneID" id="28769953"/>
    <dbReference type="InParanoid" id="A0A177CSH8"/>
    <dbReference type="OrthoDB" id="21615at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029154">
        <property type="entry name" value="HIBADH-like_NADP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22981:SF7">
        <property type="entry name" value="3-HYDROXYISOBUTYRATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22981">
        <property type="entry name" value="3-HYDROXYISOBUTYRATE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14833">
        <property type="entry name" value="NAD_binding_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3-hydroxyisobutyrate dehydrogenase-like NAD-binding" evidence="3">
        <location>
            <begin position="42"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAG10494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="196" mass="21978" checksum="651AE7FF955AEDB2" modified="2016-09-07" version="1">MHATDAGECTLMVGSSFPDIYQRALPVLESMGRYIFHMGPLGSGHAMKTINNYVIASGLCALYESLVAGKKWGLEPQTIVDVLNVGTAVNFCSLDTVRRDMLTREFRSGFALALLVNDLGITQEFMREVGFETELPGVLRGHLRDALGVVEKCADHTEAIRGWERRVGLELKRTVRVDRIREEDFRHRLEGLNRIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CSI0</accession>
    <name>A0A177CSI0_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CC84DRAFT_1256315</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040850.1">
        <property type="nucleotide sequence ID" value="XM_018184611.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CSI0"/>
    <dbReference type="STRING" id="1460663.A0A177CSI0"/>
    <dbReference type="ESTHER" id="9pleo-a0a177csi0">
        <property type="family name" value="Fungal_carboxylesterase_lipase"/>
    </dbReference>
    <dbReference type="GeneID" id="28768097"/>
    <dbReference type="InParanoid" id="A0A177CSI0"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000299">
        <property type="entry name" value="Carboxylic ester hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007948981" description="Carboxylic ester hydrolase" evidence="3">
        <location>
            <begin position="22"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="28"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAG10485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="539" mass="58448" checksum="6900ACA7666872D5" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CSW5</accession>
    <name>A0A177CSW5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycoside hydrolase family 95 protein-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CC84DRAFT_1255799</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG09857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040222.1">
        <property type="nucleotide sequence ID" value="XM_018184572.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CSW5"/>
    <dbReference type="STRING" id="1460663.A0A177CSW5"/>
    <dbReference type="GeneID" id="28768058"/>
    <dbReference type="InParanoid" id="A0A177CSW5"/>
    <dbReference type="OrthoDB" id="2848340at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004560">
        <property type="term" value="F:alpha-L-fucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049053">
        <property type="entry name" value="AFCA-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016518">
        <property type="entry name" value="Alpha-L-fucosidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054363">
        <property type="entry name" value="GH95_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027414">
        <property type="entry name" value="GH95_N_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31084:SF3">
        <property type="entry name" value="ALPHA-FUCOSIDASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31084">
        <property type="entry name" value="ALPHA-L-FUCOSIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14498">
        <property type="entry name" value="Glyco_hyd_65N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21307">
        <property type="entry name" value="Glyco_hydro_95_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22124">
        <property type="entry name" value="Glyco_hydro_95_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007663">
        <property type="entry name" value="UCP007663"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008058550" evidence="1">
        <location>
            <begin position="20"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 95 N-terminal" evidence="2">
        <location>
            <begin position="22"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 95 catalytic" evidence="4">
        <location>
            <begin position="301"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha fucosidase A-like C-terminal" evidence="3">
        <location>
            <begin position="738"/>
            <end position="774"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF21307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF22124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAG09857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="794" mass="86831" checksum="41C206F126BB5AFE" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CU84</accession>
    <name>A0A177CU84_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF676 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1238431</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG11105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041470.1">
        <property type="nucleotide sequence ID" value="XM_018183939.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CU84"/>
    <dbReference type="STRING" id="1460663.A0A177CU84"/>
    <dbReference type="GeneID" id="28767425"/>
    <dbReference type="InParanoid" id="A0A177CU84"/>
    <dbReference type="OrthoDB" id="202545at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42044:SF2">
        <property type="entry name" value="DUF676 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42044">
        <property type="entry name" value="DUF676 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG11105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="405" mass="44966" checksum="86985D33F05150CB" modified="2016-09-07" version="1">MPTLATLIGGLSTINNTVTSNEINKATLALIWRDSAELGKFLVGLLDPIKCYVLANSGSGIAAPSEEHGTDNELDLTDPMNRHAVICQFQRLVRSVVFILTNMTQDTIQAIDIIPQTKLLSDDQTPGDIMEPSSPTSAMMPQEKWIFVNGIAGELWWLKVACRKLATKYRRDVTGVFNRGDGILWDLIECAGERSLHGSERAASQRQLIQRTASSNNAQVALRSKLEEALAAEGDEKIVVIAHSQGCLLLRLALEDILVGRTSFFPASTRTESDLETYAWARQKMRSQLYVFTFGNPSVDWRLETTDITQSEFGTYISRQDPAYLSSYVYRTEHFANDQDFVAKLGVLSSSRPADSGYSNVFINDRPTWIGHLFGTQYSLDPTHYQPNGQISRLLTCVPGQPIPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CUL1</accession>
    <name>A0A177CUL1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Pyridoxamine 5'-phosphate oxidase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1161391</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040814.1">
        <property type="nucleotide sequence ID" value="XM_018177724.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CUL1"/>
    <dbReference type="FunCoup" id="A0A177CUL1">
        <property type="interactions" value="30"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CUL1"/>
    <dbReference type="GeneID" id="28761210"/>
    <dbReference type="InParanoid" id="A0A177CUL1"/>
    <dbReference type="OrthoDB" id="5300823at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052841">
        <property type="entry name" value="PMP_oxidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28040">
        <property type="entry name" value="PYRIDOXAMINE 5'-PHOSPHATE OXIDASE YLR456W HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28040:SF1">
        <property type="entry name" value="PYRIDOXAMINE 5'-PHOSPHATE OXIDASE YLR456W HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="PNPOx_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyridoxamine 5'-phosphate oxidase N-terminal" evidence="2">
        <location>
            <begin position="9"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="92"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG10449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="234" mass="25055" checksum="ACDEFF688A5A8135" modified="2016-09-07" version="1">MASPNGLPGEVTVCLQNARFLHLATSASNVPHISLMNYTYLPSTPYSPHPTIIMTTPPSSQKTHNLESNPLVSLLVHDWVSHRPPTLDARNRSPSPSRPNPRSGSLAELLLGMNTASLSRISTTINGLATIVPSGSEEEAWYKAQHLANNTFGPSEDSYSSSPVGGLWGGGGLESQRQDEEMVEGDGGTRCYVEGEEVRVVVVRIRDGRVADWKGQVRDWVVGDVGGSGLANGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CUP6</accession>
    <name>A0A177CUP6_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1194182</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041296.1">
        <property type="nucleotide sequence ID" value="XM_018181339.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CUP6"/>
    <dbReference type="STRING" id="1460663.A0A177CUP6"/>
    <dbReference type="GeneID" id="28764825"/>
    <dbReference type="InParanoid" id="A0A177CUP6"/>
    <dbReference type="OrthoDB" id="5130013at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF39">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG10931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="488" mass="54981" checksum="32961C359805D93F" modified="2016-09-07" version="1">MTNPISHTTGYRYAAPICAHPKSSKPDTEGKERGLQLSWPFGSQHRRAIVSKGPVGIDTVHVREILHTSSEDIQRHSHLTQGSFDKSEWQVLELAIPLVPAVKVEVENQDRFQYFQHTASKALAILGHEPKALGNVLIRIALASNTSSAKAVRECILAYSALHRHGIHPQAVESKIAGLNALKVASFTEPNGIDNLEAIQHVAAGMLLLSFEIHLSICTSDDWTKYLCGVKNIIRAAGLDTLDQDQDLAILLDWVYYQDVLARFSLRHWYRQYGKPALNLITVTCTPADTTLHMTDWIDQSMRRKSANLNLISLLSELCDAVPKPLCGLPYSEVDERKRFLEILEWKIRNLEPSPVAYDHERSPLIMELYKLAMLVYLHRVTAGQLKQTVNMQFQIDRAFEILLQLGSCERQFPVFVFGCEARTDAQRAIILDTMSRTESSVSSRSLNHARLLLQAIWAQDDLAEGKTLYWKKISYVISCCTIPPSFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CUS2</accession>
    <name>A0A177CUS2_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CC84DRAFT_1238242</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. TCR/Tet family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041351.1">
        <property type="nucleotide sequence ID" value="XM_018183931.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CUS2"/>
    <dbReference type="GeneID" id="28767417"/>
    <dbReference type="InParanoid" id="A0A177CUS2"/>
    <dbReference type="OrthoDB" id="10021397at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF12">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="66"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="1"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAG10986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="132" mass="14056" checksum="D1289A80D1AD25ED" modified="2016-09-07" version="1">MQQQMAVHYCSVVSIFEGGSVISGAALTMAVLVFSRVLAGIGGSEIYVGTVNIVTFMTTPVERSKYLGYVAMAWSLGTILGPMIGGTFNDNLAMCLLYQIVFYSTSSTGLALLDTVFSTSYRVQLPETGQTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CWD7</accession>
    <name>A0A177CWD7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DlpA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1159291</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG11874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042239.1">
        <property type="nucleotide sequence ID" value="XM_018177186.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CWD7"/>
    <dbReference type="FunCoup" id="A0A177CWD7">
        <property type="interactions" value="9"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CWD7"/>
    <dbReference type="GeneID" id="28760672"/>
    <dbReference type="InParanoid" id="A0A177CWD7"/>
    <dbReference type="OrthoDB" id="1476984at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047443">
        <property type="term" value="F:4-hydroxy-4-methyl-2-oxoglutarate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008948">
        <property type="term" value="F:oxaloacetate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16841">
        <property type="entry name" value="RraA_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.40">
        <property type="entry name" value="Ribonuclease E inhibitor RraA/RraA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005493">
        <property type="entry name" value="RraA/RraA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036704">
        <property type="entry name" value="RraA/RraA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33254">
        <property type="entry name" value="4-HYDROXY-4-METHYL-2-OXOGLUTARATE ALDOLASE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33254:SF4">
        <property type="entry name" value="4-HYDROXY-4-METHYL-2-OXOGLUTARATE ALDOLASE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03737">
        <property type="entry name" value="RraA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89562">
        <property type="entry name" value="RraA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="114"/>
            <end position="117"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR605493-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG11874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="238" mass="25132" checksum="59F4DCE8C48D0F04" modified="2016-09-07" version="1">MASSKWKELSRYSACDIADALLKLGVPGAGFLPDITPMPHTSGLRKPELKKIIAPASTFLMAPKATPSFPNPVTLSKDFPKSNSSATGPYADLTQPGTVVIVSQPPGQSCAVMGGIMAERMKVLGAQGVVVDGRVRDLVALAETGLPIWSKGSSIIGAGAETRLHAYEVPVRVGKTVIEPGDIVMIDPFENGVVAVPQGKVDEVLQLLPKLVGADDKVISDVKNGRRVDEAFEEHRNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CWU6</accession>
    <name>A0A177CWU6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">60S ribosomal protein L4-A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CC84DRAFT_1159394</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG11993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042358.1">
        <property type="nucleotide sequence ID" value="XM_018177219.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CWU6"/>
    <dbReference type="FunCoup" id="A0A177CWU6">
        <property type="interactions" value="1359"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CWU6"/>
    <dbReference type="GeneID" id="28760705"/>
    <dbReference type="InParanoid" id="A0A177CWU6"/>
    <dbReference type="OrthoDB" id="10259785at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1370.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025755">
        <property type="entry name" value="Ribos_uL4_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002136">
        <property type="entry name" value="Ribosomal_uL4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023574">
        <property type="entry name" value="Ribosomal_uL4_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013000">
        <property type="entry name" value="Ribosomal_uL4_euk/arc_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045240">
        <property type="entry name" value="Ribosomal_uL4_euk/arch"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19431">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14374">
        <property type="entry name" value="Ribos_L4_asso_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00573">
        <property type="entry name" value="Ribosomal_L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52166">
        <property type="entry name" value="Ribosomal protein L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00939">
        <property type="entry name" value="RIBOSOMAL_L1E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL4 C-terminal" evidence="5">
        <location>
            <begin position="279"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="44"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="346"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="356"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF14374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAG11993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="371" mass="40004" checksum="D4A9DBE9926E9E00" modified="2016-09-07" version="1">MSRPTVTIISASGEASKDTAPIPNVFKSPIRPDIVHSVHTGMNKNKRQPYAVSEKAGHQTSAESWGTGRAVARIPRVSGGGTHRAGQAAFGNMCRSGRMFAPTKVWRKWHQKINLNQKRFATASALAASSSAALLLARGHNIATVPEVPLVVSSTAFADAAIAKTSAALALLKAVGAGADVEKVKKSRKVRAGKGKLRGRRYRQRRGPLVIYNPDEDGKELVGAFRNLAGVETSSVYSLNLLQLAPGGHLGRFIVWTSSAFSALDKVYGSTTEPSALKKDFLLPSALMKQPDLSKIINSSDVQKVLRPVRGGAISKRTNVQKKNPLKNFQVQLRLNPYAAAFAKEKQGQKELNAGKPERVGESFTEQLHEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CX79</accession>
    <name>A0A177CX79_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NACHT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_1211738</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042498.1">
        <property type="nucleotide sequence ID" value="XM_018182399.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CX79"/>
    <dbReference type="STRING" id="1460663.A0A177CX79"/>
    <dbReference type="GeneID" id="28765885"/>
    <dbReference type="InParanoid" id="A0A177CX79"/>
    <dbReference type="OrthoDB" id="443402at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056693">
        <property type="entry name" value="DUF7791"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF5">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25053">
        <property type="entry name" value="DUF7791"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50837">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="NACHT" evidence="3">
        <location>
            <begin position="278"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="744"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1009"/>
            <end position="1034"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAG12133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="1074" mass="123696" checksum="A3A02CD24852CE5E" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CX96</accession>
    <name>A0A177CX96_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_1159142</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG11668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042033.1">
        <property type="nucleotide sequence ID" value="XM_018177150.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CX96"/>
    <dbReference type="STRING" id="1460663.A0A177CX96"/>
    <dbReference type="GeneID" id="28760636"/>
    <dbReference type="InParanoid" id="A0A177CX96"/>
    <dbReference type="OrthoDB" id="3795566at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008058703" evidence="3">
        <location>
            <begin position="24"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="262"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="387"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="413"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="471"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAG11668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="515" mass="56703" checksum="677EA15C78729A4B" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CXK1</accession>
    <name>A0A177CXK1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Fructose-1,6-bisphosphatase</fullName>
            <ecNumber evidence="5">3.1.3.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">D-fructose-1,6-bisphosphate 1-phosphohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CC84DRAFT_1079770</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>beta-D-fructose 1,6-bisphosphate + H2O = beta-D-fructose 6-phosphate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:11064"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="EC" id="3.1.3.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="10">Carbohydrate biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the FBPase class 1 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.11" evidence="5"/>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042650.1">
        <property type="nucleotide sequence ID" value="XM_018173861.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CXK1"/>
    <dbReference type="FunCoup" id="A0A177CXK1">
        <property type="interactions" value="570"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CXK1"/>
    <dbReference type="GeneID" id="28757347"/>
    <dbReference type="InParanoid" id="A0A177CXK1"/>
    <dbReference type="OrthoDB" id="10256725at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042132">
        <property type="term" value="F:fructose 1,6-bisphosphate 1-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030388">
        <property type="term" value="P:fructose 1,6-bisphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006002">
        <property type="term" value="P:fructose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006000">
        <property type="term" value="P:fructose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005986">
        <property type="term" value="P:sucrose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00354">
        <property type="entry name" value="FBPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.540.10:FF:000009">
        <property type="entry name" value="Fructose-1,6-bisphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.80:FF:000001">
        <property type="entry name" value="Fructose-1,6-bisphosphatase class 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.540.10">
        <property type="entry name" value="Fructose-1,6-Bisphosphatase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01855">
        <property type="entry name" value="FBPase_class1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044015">
        <property type="entry name" value="FBPase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000146">
        <property type="entry name" value="FBPase_class-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033391">
        <property type="entry name" value="FBPase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028343">
        <property type="entry name" value="FBPtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020548">
        <property type="entry name" value="Fructose_bisphosphatase_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006778">
        <property type="entry name" value="PRK09293.1-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11556">
        <property type="entry name" value="FRUCTOSE-1,6-BISPHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11556:SF1">
        <property type="entry name" value="FRUCTOSE-BISPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00316">
        <property type="entry name" value="FBPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18913">
        <property type="entry name" value="FBPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500210">
        <property type="entry name" value="FBPtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000904">
        <property type="entry name" value="FBPtase_SBPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00115">
        <property type="entry name" value="F16BPHPHTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56655">
        <property type="entry name" value="Carbohydrate phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00124">
        <property type="entry name" value="FBPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fructose-1-6-bisphosphatase class I N-terminal" evidence="14">
        <location>
            <begin position="21"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="Fructose-1-6-bisphosphatase class 1 C-terminal" evidence="15">
        <location>
            <begin position="214"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00032973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00070480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF18913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OAG12285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="350" mass="38530" checksum="E00EEF180E0E786C" modified="2016-09-07" version="1">MSGKENQNGGAVGEAINTDIITLTRFLTEEQAKHKEATGDFTLLCHALQFAFKSISYYIRRSTLINLTGLAGNTNSTGDDQKKLDVIGNDLFISAMRSCGRVRLLVSEEEEECITFDEFPSARYAVACDPIDGSSNLDAGVSVGTIFSVYKLDEGAKGTKEDLLLAGTEMVASGFTMYGASAQLVITMKGGNVNGFTLDNNFGEFILTHPNMRIPKKRAIYSVNEGNSLYWEEPVKEYINGLKYPAEEGGKPYSARYIGSMVADAYRTLLYGGIFAYPADKKSPKGKLRILYECAPMAMVFENAGGLAVNSKMQRMMEVVPEHIHDRSGIFMGSEQEVQRVIDVHKKHQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CXP7</accession>
    <name>A0A177CXP7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">ATP-binding cassette transporter-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CC84DRAFT_55132</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG11818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042183.1">
        <property type="nucleotide sequence ID" value="XM_018186673.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CXP7"/>
    <dbReference type="STRING" id="1460663.A0A177CXP7"/>
    <dbReference type="GeneID" id="28770159"/>
    <dbReference type="InParanoid" id="A0A177CXP7"/>
    <dbReference type="OrthoDB" id="66620at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03213">
        <property type="entry name" value="ABCG_EPDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001305">
        <property type="entry name" value="ABCG transporter ABC superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043926">
        <property type="entry name" value="ABCG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052215">
        <property type="entry name" value="Plant_ABCG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48042">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48042:SF11">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19055">
        <property type="entry name" value="ABC2_membrane_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="366"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="400"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="444"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="482"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="507"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="607"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="31"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OAG11818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="631" mass="70248" checksum="F717E75D4CFE519D" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CXR0</accession>
    <name>A0A177CXR0_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="9">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CC84DRAFT_1225835</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Esterase involved in the hydrolysis of xylan, a major structural heterogeneous polysaccharide found in plant biomass representing the second most abundant polysaccharide in the biosphere, after cellulose.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the carbohydrate esterase 1 (CE1) family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="9"/>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042371.1">
        <property type="nucleotide sequence ID" value="XM_018183574.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CXR0"/>
    <dbReference type="STRING" id="1460663.A0A177CXR0"/>
    <dbReference type="GeneID" id="28767060"/>
    <dbReference type="InParanoid" id="A0A177CXR0"/>
    <dbReference type="OrthoDB" id="2425929at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010126">
        <property type="entry name" value="Esterase_phb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050955">
        <property type="entry name" value="Plant_Biomass_Hydrol_Est"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01840">
        <property type="entry name" value="esterase_phb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43037:SF3">
        <property type="entry name" value="FERULOYL ESTERASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43037">
        <property type="entry name" value="UNNAMED PRODUCT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10503">
        <property type="entry name" value="Esterase_PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 9 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 9" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0964">Secreted</keyword>
    <keyword evidence="2 9" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5029037674" description="Carboxylic ester hydrolase" evidence="9">
        <location>
            <begin position="19"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAG12006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="302" mass="32668" checksum="37AFB8519E6E6851" modified="2016-09-07" version="1">MRLLELITGLAAFAGVQGASVGTDHQIIKRASLTQVQNFGNNPSGIKMFIYVPQKLQAKPPVVLVLHACAWTAGNFFATTKYGQLADQHGYVLIYGQTPTDGACWDVSSTQTLTHDGGSDSTGLANMVRYALQKYNGDASKVYVTGESSGAMMTQVMSAVYPDMFAAASEFSGEPAGCFYTGTVRGWNSQCAGGQLHKTPAEWAKQVHAMYPSYTGQYPRMQIYHGDVDTTLNIASFNESIKEWSGIFGYSGNPTKTQANNPGAKLTRYTYGDRLQGIWGHGIGHVVPTNETEALKWFGITS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CY58</accession>
    <name>A0A177CY58_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Catabolite repression protein creC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_1254210</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Component of the regulatory network controlling carbon source utilization through ubiquitination and deubiquitination involving creA, creB, creC, creD and acrB. Required to prevent the proteolysis of the CreB deubiquitinating enzyme in the absence of carbon catabolite repression. CreB deubiquitinating enzyme stabilized in a complex with the CreC leads to the expression of genes such as those in the proline and quinate pathways.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Interacts with creB.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the WD repeat creC family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG11822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042187.1">
        <property type="nucleotide sequence ID" value="XM_018184441.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CY58"/>
    <dbReference type="STRING" id="1460663.A0A177CY58"/>
    <dbReference type="GeneID" id="28767927"/>
    <dbReference type="InParanoid" id="A0A177CY58"/>
    <dbReference type="OrthoDB" id="3367at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051286">
        <property type="term" value="C:cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045013">
        <property type="term" value="P:carbon catabolite repression of transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051362">
        <property type="entry name" value="WD_repeat_creC_regulators"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14107:SF16">
        <property type="entry name" value="AT02583P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14107">
        <property type="entry name" value="WD REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="410"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="57"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="101"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="593"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="107"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="604"/>
            <end position="614"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00037241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAG11822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="614" mass="67605" checksum="C8B942226F738CCB" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CY87</accession>
    <name>A0A177CY87_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Amino acid transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_1192217</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG11800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042165.1">
        <property type="nucleotide sequence ID" value="XM_018181233.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CY87"/>
    <dbReference type="STRING" id="1460663.A0A177CY87"/>
    <dbReference type="GeneID" id="28764719"/>
    <dbReference type="InParanoid" id="A0A177CY87"/>
    <dbReference type="OrthoDB" id="3257095at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF1">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="44"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="78"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="169"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="201"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="242"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="275"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="320"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="381"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="407"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="450"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="482"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAG11800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="524" mass="56654" checksum="F60E6ECC4D4350B1" modified="2016-09-07" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CZ89</accession>
    <name>A0A177CZ89_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Peptidase S54 rhomboid domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CC84DRAFT_1182961</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042597.1">
        <property type="nucleotide sequence ID" value="XM_018180655.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CZ89"/>
    <dbReference type="FunCoup" id="A0A177CZ89">
        <property type="interactions" value="16"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CZ89"/>
    <dbReference type="GeneID" id="28764141"/>
    <dbReference type="InParanoid" id="A0A177CZ89"/>
    <dbReference type="OrthoDB" id="272778at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43066">
        <property type="entry name" value="RHOMBOID-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43066:SF21">
        <property type="entry name" value="UBIQUITIN-ASSOCIATED DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="49"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="87"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="120"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="258"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAG12232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="292" mass="32216" checksum="214CCEF249DE476B" modified="2016-09-07" version="1">MITSGFTNAPVSQFLVFGVVIGALVASLTDTRYYIHIQVVPHIWKYGQFWRFLTWQICFTNSTEVLFAAVSLYNLRVIERLWGSRKFASFLLATLPYTTLLPPLILTFLLRPLTFGRLNFLPAGPTPIIFALLANYYAAIPYTYRYKIAPYSSTPPATSPSSPNAAQTATSIWAKSITFTSKATTYLPPLQLALSQFPGSLLGAAVGWAIGTAYRRDVLPYASSWRVPGWMVGEEKKRGFEGLRARLDAEREREGAGGGLATGILAGETQGGQARQRRTLGDMVAEQFRGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CZC5</accession>
    <name>A0A177CZC5_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Pectate lyase</fullName>
            <ecNumber evidence="10">4.2.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CC84DRAFT_1182991</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Pectinolytic enzyme consist of four classes of enzymes: pectin lyase, polygalacturonase, pectin methylesterase and rhamnogalacturonase. Among pectinolytic enzymes, pectin lyase is the most important in depolymerization of pectin, since it cleaves internal glycosidic bonds of highly methylated pectins. Favors pectate, the anion, over pectin, the methyl ester.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>Eliminative cleavage of (1-&gt;4)-alpha-D-galacturonan to give oligosaccharides with 4-deoxy-alpha-D-galact-4-enuronosyl groups at their non-reducing ends.</text>
            <dbReference type="EC" id="4.2.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 10">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 10">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the polysaccharide lyase 3 family.</text>
    </comment>
    <dbReference type="EC" id="4.2.2.2" evidence="10"/>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042642.1">
        <property type="nucleotide sequence ID" value="XM_018180657.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CZC5"/>
    <dbReference type="STRING" id="1460663.A0A177CZC5"/>
    <dbReference type="GeneID" id="28764143"/>
    <dbReference type="InParanoid" id="A0A177CZC5"/>
    <dbReference type="OrthoDB" id="441042at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030570">
        <property type="term" value="F:pectate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045490">
        <property type="term" value="P:pectin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004898">
        <property type="entry name" value="Pectate_lyase_PlyH/PlyE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33407">
        <property type="entry name" value="PECTATE LYASE F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33407:SF9">
        <property type="entry name" value="PECTATE LYASE F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03211">
        <property type="entry name" value="Pectate_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0106">Calcium</keyword>
    <keyword evidence="8 10 11" id="KW-0456">Lyase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025092238" description="Pectate lyase" evidence="10">
        <location>
            <begin position="18"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU367009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OAG12277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="256" mass="26227" checksum="EB81A5D25B40656E" modified="2016-09-07" version="1">MHSQTFLLSALASIASSAHIAARATTNTNLQTAFPASSGTTNLAAARTLAAGESLDGGMKQWDRSPSTCNEQAEGGDADAVFVLKDGAVLSNVIIGPNNGEGVHCLGTCTLNNVWWTDVCEDAATFKQSSGTSYVNGGGARKADDKVLQHNGGGTVAVKNFWAQDVGKVYRSCGNCGTQYARKSTFDNIKMSGGSVVAGVNGNLGDTTTIKNSCVLDGATHVCWLYKGVTSGEPSKTASVADGKVCATSAIKTSGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CZR5</accession>
    <name>A0A177CZR5_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">Aminomethyltransferase</fullName>
            <ecNumber evidence="4 12">2.1.2.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9 12">Glycine cleavage system T protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CC84DRAFT_1160239</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">The glycine cleavage system catalyzes the degradation of glycine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 12">
            <text>N(6)-[(R)-S(8)-aminomethyldihydrolipoyl]-L-lysyl-[protein] + (6S)-5,6,7,8-tetrahydrofolate = N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] + (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:16945"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="Rhea" id="RHEA-COMP:10492"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="ChEBI" id="CHEBI:83143"/>
            <dbReference type="EC" id="2.1.2.10"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3 12">The glycine cleavage system is composed of four proteins: P, T, L and H.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the GcvT family.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.10" evidence="4 12"/>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018043359.1">
        <property type="nucleotide sequence ID" value="XM_018177450.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CZR5"/>
    <dbReference type="FunCoup" id="A0A177CZR5">
        <property type="interactions" value="1207"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CZR5"/>
    <dbReference type="GeneID" id="28760936"/>
    <dbReference type="InParanoid" id="A0A177CZR5"/>
    <dbReference type="OrthoDB" id="10263536at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005960">
        <property type="term" value="C:glycine cleavage complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004047">
        <property type="term" value="F:aminomethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006546">
        <property type="term" value="P:glycine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.110:FF:000002">
        <property type="entry name" value="Aminomethyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1400:FF:000001">
        <property type="entry name" value="Aminomethyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1250.10:FF:000002">
        <property type="entry name" value="Aminomethyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.110">
        <property type="entry name" value="Aminomethyltransferase beta-barrel domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1400">
        <property type="entry name" value="Aminomethyltransferase beta-barrel domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1250.10">
        <property type="entry name" value="Aminomethyltransferase fragment"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.120">
        <property type="entry name" value="Probable tRNA modification gtpase trme, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006223">
        <property type="entry name" value="GcvT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028896">
        <property type="entry name" value="GcvT/YgfZ/DmdA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029043">
        <property type="entry name" value="GcvT/YgfZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013977">
        <property type="entry name" value="GcvT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006222">
        <property type="entry name" value="GCVT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027266">
        <property type="entry name" value="TrmE/GcvT-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00528">
        <property type="entry name" value="gcvT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001567">
        <property type="entry name" value="PRK00389.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43757">
        <property type="entry name" value="AMINOMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43757:SF2">
        <property type="entry name" value="AMINOMETHYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01571">
        <property type="entry name" value="GCV_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08669">
        <property type="entry name" value="GCV_T_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006487">
        <property type="entry name" value="GcvT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101790">
        <property type="entry name" value="Aminomethyltransferase beta-barrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103025">
        <property type="entry name" value="Folate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="8 12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 12" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="GCVT N-terminal" evidence="13">
        <location>
            <begin position="74"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="Aminomethyltransferase C-terminal" evidence="14">
        <location>
            <begin position="370"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="277"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR006487-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF08669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OAG12994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="460" mass="49613" checksum="3AF6060A8287BB9C" modified="2016-09-07" version="1">MASKRAAQLLRPAVNGFKASSVSLQHAVQHQTTIRSLATRAGRARKPARVSTTAVRFASTATPTSDGQLGRTGLYELHAKHGAKFVPFGGYEMPVQYSDLSIVDSHHWTRQKASLFDVGHMVQHDFSGPGAQAFLERLTPSSLSSLSENHSTLSTLLHPDTGGIVDDTVITRLANSFYVVTNAGCREKDLAYLTEQLETWRKDNPDKTVEWKLRTNQGLVALQGPLAATILERALSEQSASALKSLYFGQCMPGTIKGTDVEVLISRGGYTGEDGFEISIPPPATEAVTQFLLDSAKDELRLAGLGARDTLRLEAGMCLYGHDLDDTTTPVEAGLSWIIGKDRRANGGFHGDSVILQQLKKKSEGGGVTRRRVGLIIEGSPAREGAEIVDEAGEKIGNITSGCPSPTAKKNISMGYIKDGMHKSGTQVQVIVRGKKRKATVTKMPFIGSKYYKAPAPDPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177D074</accession>
    <name>A0A177D074_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1212271</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018043133.1">
        <property type="nucleotide sequence ID" value="XM_018182438.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177D074"/>
    <dbReference type="GeneID" id="28765924"/>
    <dbReference type="InParanoid" id="A0A177D074"/>
    <dbReference type="OrthoDB" id="3782790at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008058824" evidence="1">
        <location>
            <begin position="20"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG12768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="244" mass="26605" checksum="2458BAE87B76F7BE" modified="2016-09-07" version="1">MRFFTFLPALAPLCGLAASAAVSAAGSGVQKLFERSQLALQAPKLHRAPEGHIQRKRDAEQMFTFGGYASNLTGDGNYLKLEEPIEANGHPHPWCQGFEGSNGYTEGQEPTIHYVHMDKAKNESDPPGIPQYICWFYNDFDCDPTKGAVGSFKFTHTHLTDLDKKDKNGDDSNTNRDFPLMSGGANRFEWIKAYGCMFYVDNPSANEDSGNDVGQAGIAQDGTTGTELSAAELEAGQMIRALAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177D0K4</accession>
    <name>A0A177D0K4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ricin B lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1201479</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042864.1">
        <property type="nucleotide sequence ID" value="XM_018181723.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177D0K4"/>
    <dbReference type="GeneID" id="28765209"/>
    <dbReference type="InParanoid" id="A0A177D0K4"/>
    <dbReference type="OrthoDB" id="3770800at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008058835" description="Ricin B lectin domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG12499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="120" mass="12471" checksum="DAC3B841F8E3E84B" modified="2016-09-07" version="1">MQLSILAIIAPLLATVHAGCYSGGETWAPDQVQANNALDGVCNGLSGGFGGKQTKYACVNAGTANKRFEFWVTNTAGNSLSLNKGDCVLRLSNEINGCQNGGDTTTAGWNFRADPNAGRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177D1A2</accession>
    <name>A0A177D1A2_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GRF-like zinc ribbon domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1079568</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG13188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018043553.1">
        <property type="nucleotide sequence ID" value="XM_018173854.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177D1A2"/>
    <dbReference type="GeneID" id="28757340"/>
    <dbReference type="InParanoid" id="A0A177D1A2"/>
    <dbReference type="OrthoDB" id="4469945at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056444">
        <property type="entry name" value="Zn_ribbon_GRF_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23549">
        <property type="entry name" value="Zn_ribbon_GRF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GRF-like zinc ribbon" evidence="1">
        <location>
            <begin position="10"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF23549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG13188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="122" mass="13521" checksum="2CB0637EEFC2259F" modified="2016-09-07" version="1">MTTSSTPAYPSRCRRCDSRVTLMFTRSNNRIGNAGRPYYKCLTCTKFLCFADSRGLDPSNPLCSCGIPSRRQISGPARCVPRGLHYVCSQGGCSFYSPMHGDYGQISLDEEIASLFIQLSFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177D1M8</accession>
    <name>A0A177D1M8_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DNA mismatch repair protein MSH5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">MutS protein homolog 5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CC84DRAFT_1255161</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DNA mismatch repair MutS family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG13030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018043395.1">
        <property type="nucleotide sequence ID" value="XM_018184511.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177D1M8"/>
    <dbReference type="FunCoup" id="A0A177D1M8">
        <property type="interactions" value="142"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177D1M8"/>
    <dbReference type="GeneID" id="28767997"/>
    <dbReference type="InParanoid" id="A0A177D1M8"/>
    <dbReference type="OrthoDB" id="29596at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051026">
        <property type="term" value="P:chiasma assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03281">
        <property type="entry name" value="ABC_MSH5_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001067">
        <property type="entry name" value="DNA mismatch repair protein MSH5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011184">
        <property type="entry name" value="DNA_mismatch_repair_Msh2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007696">
        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361:SF20">
        <property type="entry name" value="MUTS PROTEIN HOMOLOG 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05192">
        <property type="entry name" value="MutS_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005813">
        <property type="entry name" value="MSH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00533">
        <property type="entry name" value="MUTSd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="DNA repair protein MutS, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00486">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0469">Meiosis</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair proteins mutS family" evidence="13">
        <location>
            <begin position="718"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="16"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00073549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00077470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS00486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OAG13030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="885" mass="97974" checksum="DFB99978DA26E0D3" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BU33</accession>
    <name>A0A177BU33_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Metallo-beta-lactamase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1169657</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441563">
        <property type="protein sequence ID" value="OAF98922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029288.1">
        <property type="nucleotide sequence ID" value="XM_018179715.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BU33"/>
    <dbReference type="STRING" id="1460663.A0A177BU33"/>
    <dbReference type="GeneID" id="28763201"/>
    <dbReference type="InParanoid" id="A0A177BU33"/>
    <dbReference type="OrthoDB" id="17458at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36839">
        <property type="entry name" value="METALLO-BETA-LACTAMASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_5G12770)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36839:SF1">
        <property type="entry name" value="METALLO-BETA-LACTAMASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_5G12770)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="1">
        <location>
            <begin position="18"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAF98922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="234" mass="26003" checksum="FBF72BE168D170D1" modified="2016-09-07" version="1">MPAGLSESTSTTKQLGIGERAILLQTSSGNVLWDLVAWLDDATVAFIKSKGGLQAIVISHPHFWTTHLEWARVFGCPVYLQEADQEWIQRKEDPQGLRHFISGETEILPGVTSLQAGGHFPGSSFLHWDNKLFIADTMMSVPSGFSKPNGSKSNPKAATYSFMWAYPNMIPLPPSEVLGIWRSIKGWDFESTYGGFMGQNVVGRKNLKKEVLESAQMFLRKGGHEKAEIFEETV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BU83</accession>
    <name>A0A177BU83_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Calcineurin-like phosphoesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_1169944</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441564">
        <property type="protein sequence ID" value="OAF98814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029180.1">
        <property type="nucleotide sequence ID" value="XM_018179798.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BU83"/>
    <dbReference type="FunCoup" id="A0A177BU83">
        <property type="interactions" value="70"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177BU83"/>
    <dbReference type="GeneID" id="28763284"/>
    <dbReference type="InParanoid" id="A0A177BU83"/>
    <dbReference type="OrthoDB" id="9984693at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033308">
        <property type="entry name" value="PGAP5/Cdc1/Ted1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13315">
        <property type="entry name" value="METALLO PHOSPHOESTERASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13315:SF1">
        <property type="entry name" value="PROTEIN TED1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="565"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="190"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="458"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="598"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="190"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="458"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="473"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="609"/>
            <end position="619"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAF98814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="638" mass="70700" checksum="C5106AAF3A140A49" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BUN7</accession>
    <name>A0A177BUN7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">nicotinamidase</fullName>
            <ecNumber evidence="6">3.5.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Nicotinamide deamidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CC84DRAFT_1191698</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; nicotinate biosynthesis; nicotinate from nicotinamide: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the isochorismatase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.19" evidence="6"/>
    <dbReference type="EMBL" id="KV441564">
        <property type="protein sequence ID" value="OAF98855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029221.1">
        <property type="nucleotide sequence ID" value="XM_018181199.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BUN7"/>
    <dbReference type="FunCoup" id="A0A177BUN7">
        <property type="interactions" value="423"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177BUN7"/>
    <dbReference type="GeneID" id="28764685"/>
    <dbReference type="InParanoid" id="A0A177BUN7"/>
    <dbReference type="OrthoDB" id="3341310at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008936">
        <property type="term" value="F:nicotinamidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019363">
        <property type="term" value="P:pyridine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01011">
        <property type="entry name" value="nicotinamidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="entry name" value="Isochorismatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052347">
        <property type="entry name" value="Isochorismatase_Nicotinamidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11080:SF2">
        <property type="entry name" value="LD05707P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11080">
        <property type="entry name" value="PYRAZINAMIDASE/NICOTINAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="Isochorismatase-like hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase-like" evidence="8">
        <location>
            <begin position="8"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00039017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00043224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAF98855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="225" mass="24783" checksum="8D7C51EA8AE20537" modified="2016-09-07" version="1">MSSRFKPALVLVDVQEDFCPPNGSLAVQGGRDIVPLLNELLDRPFAIKVATKDFHPPDHISFASNHDAPNNKPFESTITIANPLNPSETQETRLWPDHCVQGTKGAELLPELNVTKVHEIVEKGQDTRVEMYSAFADPFKSPCVSKSRLAKLLHDAEITDVFVAGLAADYCVRYTALDAAREGFKTRVIGEATRAVDPSSMDSVLKEYDEAGVTVIEKDDESLSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BVQ4</accession>
    <name>A0A177BVQ4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">CobW-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_1157544</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the SIMIBI class G3E GTPase family. ZNG1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV441562">
        <property type="protein sequence ID" value="OAF99482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029848.1">
        <property type="nucleotide sequence ID" value="XM_018177015.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BVQ4"/>
    <dbReference type="STRING" id="1460663.A0A177BVQ4"/>
    <dbReference type="GeneID" id="28760501"/>
    <dbReference type="InParanoid" id="A0A177BVQ4"/>
    <dbReference type="OrthoDB" id="272672at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03112">
        <property type="entry name" value="CobW-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1220.10">
        <property type="entry name" value="CobW-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036627">
        <property type="entry name" value="CobW-likC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011629">
        <property type="entry name" value="CobW-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003495">
        <property type="entry name" value="CobW/HypB/UreG_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051927">
        <property type="entry name" value="Zn_Chap_cDPG_Synth"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43603">
        <property type="entry name" value="COBW DOMAIN-CONTAINING PROTEIN DDB_G0274527"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43603:SF1">
        <property type="entry name" value="ZINC-REGULATED GTPASE METALLOPROTEIN ACTIVATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02492">
        <property type="entry name" value="cobW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07683">
        <property type="entry name" value="CobW_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00833">
        <property type="entry name" value="CobW_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90002">
        <property type="entry name" value="Hypothetical protein YjiA, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CobW C-terminal" evidence="7">
        <location>
            <begin position="317"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="348"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="348"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00034320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAF99482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="545" mass="61389" checksum="30B33049529032B3" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BVY5</accession>
    <name>A0A177BVY5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1238518</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441568">
        <property type="protein sequence ID" value="OAF98526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018028892.1">
        <property type="nucleotide sequence ID" value="XM_018183945.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BVY5"/>
    <dbReference type="GeneID" id="28767431"/>
    <dbReference type="InParanoid" id="A0A177BVY5"/>
    <dbReference type="OrthoDB" id="3626988at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAF98526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="219" mass="24165" checksum="CD3D8DA1E053A3AE" modified="2016-09-07" version="1">MPTKLLDLSDELLSRICSHGMVHEHHQQNLPQTLQHPIARHEYLETNVVVLNLSDIRGSASRLEFGYGAAQMIMTGNPGPLLRSLVHVQLSVSVTGTQGRSLAREAEDLKRLMDSCRNLRTLHFFVQADESVLHGSAAELRQGDVVALRSPDSRDRRVAEAVVNLAKSVPLRVVTVSFCPWRRGAVVVQMVDRDTADVVDACLAGGIDQTYEGLIARVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BXE3</accession>
    <name>A0A177BXE3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">asparagine--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CC84DRAFT_1156933</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.22" evidence="3"/>
    <dbReference type="EMBL" id="KV441561">
        <property type="protein sequence ID" value="OAF99805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030171.1">
        <property type="nucleotide sequence ID" value="XM_018176991.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BXE3"/>
    <dbReference type="FunCoup" id="A0A177BXE3">
        <property type="interactions" value="491"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177BXE3"/>
    <dbReference type="GeneID" id="28760477"/>
    <dbReference type="InParanoid" id="A0A177BXE3"/>
    <dbReference type="OrthoDB" id="43906at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004816">
        <property type="term" value="F:asparagine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015093">
        <property type="term" value="F:ferrous iron transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006421">
        <property type="term" value="P:asparaginyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048250">
        <property type="term" value="P:iron import into the mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04318">
        <property type="entry name" value="EcAsnRS_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000029">
        <property type="entry name" value="Solute carrier family 25 member 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004522">
        <property type="entry name" value="Asn-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00457">
        <property type="entry name" value="asnS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45758:SF4">
        <property type="entry name" value="MITOFERRIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45758">
        <property type="entry name" value="MITOFERRIN-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="13 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="17">
        <location>
            <begin position="173"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="15">
        <location>
            <begin position="496"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="15">
        <location>
            <begin position="595"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="15">
        <location>
            <begin position="686"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="OAF99805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="792" mass="85668" checksum="5C45B59277AC3F7F" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BXL0</accession>
    <name>A0A177BXL0_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">NADH-cytochrome b5 reductase</fullName>
            <ecNumber evidence="10">1.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CC84DRAFT_1169529</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>2 Fe(III)-[cytochrome b5] + NADH = 2 Fe(II)-[cytochrome b5] + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46680"/>
            <dbReference type="Rhea" id="RHEA-COMP:10438"/>
            <dbReference type="Rhea" id="RHEA-COMP:10439"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.6.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 9 10">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion outer membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.6.2.2" evidence="10"/>
    <dbReference type="EMBL" id="KV441562">
        <property type="protein sequence ID" value="OAF99428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029794.1">
        <property type="nucleotide sequence ID" value="XM_018179682.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BXL0"/>
    <dbReference type="STRING" id="1460663.A0A177BXL0"/>
    <dbReference type="GeneID" id="28763168"/>
    <dbReference type="InParanoid" id="A0A177BXL0"/>
    <dbReference type="OrthoDB" id="432685at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090524">
        <property type="term" value="F:cytochrome-b5 reductase activity, acting on NADH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06183">
        <property type="entry name" value="cyt_b5_reduct_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000009">
        <property type="entry name" value="NADH-cytochrome b5 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001834">
        <property type="entry name" value="CBR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370">
        <property type="entry name" value="NADH-CYTOCHROME B5 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370:SF101">
        <property type="entry name" value="NADH-CYTOCHROME B5 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00406">
        <property type="entry name" value="CYTB5RDTASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9 10" id="KW-0274">FAD</keyword>
    <keyword evidence="4 9 10" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 10" id="KW-0520">NAD</keyword>
    <keyword evidence="6 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="11">
        <location>
            <begin position="47"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR601834-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OAF99428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="291" mass="32042" checksum="FC3569B54B34E0F9" modified="2016-09-07" version="1">MALPLRPRTIVAGLTASSIGAGLLLSRLGRDVDADANAPKKVFGRGPAFVSLPLESEEQVNHDTKRLRFSLPNSTDISGLSLTSAVLTLSWPQGRWTPVVRPYTPVSHINEPGILELLVKHYPNGKQSTHLHSLKPGDKLIFAAAIRGYQWVPNSVPHVTLIAGGAGITPVFQLAQGILSNPDDKTAVTIVYGVNTNDDCHLKKEFEKYEKEFEDRFKVVYTVSRPDEKTTLRKGRVTKELLEEVAPMPSNGETKVFVCGPPEMEANLVGSRKEQGILEQLGYRKDQIHTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BY29</accession>
    <name>A0A177BY29_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ubiquitin-like protease family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CC84DRAFT_1232461</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C48 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441561">
        <property type="protein sequence ID" value="OAF99850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030216.1">
        <property type="nucleotide sequence ID" value="XM_018183761.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BY29"/>
    <dbReference type="GeneID" id="28767247"/>
    <dbReference type="InParanoid" id="A0A177BY29"/>
    <dbReference type="OrthoDB" id="3800536at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019783">
        <property type="term" value="F:ubiquitin-like protein peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.395.10">
        <property type="entry name" value="Adenoviral Proteinase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003653">
        <property type="entry name" value="Peptidase_C48_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02902">
        <property type="entry name" value="Peptidase_C48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like protease family profile" evidence="6">
        <location>
            <begin position="634"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="254"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="455"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="886"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="32"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="331"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="507"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAF99850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="956" mass="104863" checksum="AE62D9D00054EBC0" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BY50</accession>
    <name>A0A177BY50_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CC84DRAFT_374199</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441561">
        <property type="protein sequence ID" value="OAF99621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029987.1">
        <property type="nucleotide sequence ID" value="XM_018185954.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BY50"/>
    <dbReference type="GeneID" id="28769440"/>
    <dbReference type="InParanoid" id="A0A177BY50"/>
    <dbReference type="OrthoDB" id="194139at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507:SF8">
        <property type="entry name" value="MFS GENERAL SUBSTRATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507">
        <property type="entry name" value="ZGC:174356"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="207"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="248"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="275"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="307"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="345"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAF99621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="366" mass="39304" checksum="35669A31E7F21EFC" modified="2016-09-07" version="1">MSVWAVAVGHSDHILPTKAIIAGPVLAVLGGECVLQSTVFTLTSAMANDYVDRAKFFSYISSTSYVVSFLGPTLASFAMSRNLWAPFCLNILLLGLAVPVIKLLPGNGLVPIKSIMSVDSNDTAGEVGPLLRQSEDGPDHYSSAFETHPSILQRIVSTIRQLIALVDGRPNFQIMLCSFFLTALASSDTKLLVQYISKRYSWTFAQAGYMLSAKAIVNFTLLAIVVPRVVKSSASWKAVHGSEVRMNYAGAQISILISVVGVLCVALAFKFWMLLAALMIYALGSALPVFTMSLVKSPLIALTHSDIQDFSIVMLTKTLGSLVGAPFMTVLWVRAIEIGGVGLGLPYFVSGCIYLTAALVVARLKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BY65</accession>
    <name>A0A177BY65_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Extracellular membrane protein CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1222968</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441562">
        <property type="protein sequence ID" value="OAF99269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029635.1">
        <property type="nucleotide sequence ID" value="XM_018183445.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BY65"/>
    <dbReference type="GeneID" id="28766931"/>
    <dbReference type="InParanoid" id="A0A177BY65"/>
    <dbReference type="OrthoDB" id="3692961at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008057527" description="Extracellular membrane protein CFEM domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAF99269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="221" mass="23671" checksum="78935A9D49D67FB1" modified="2016-09-07" version="1">MQLTVTLLALTSLTLTSAFPYAHPQDAPSTVAPIPLPTLSIPADPTVSVPLSTSLNVPTTLPTLLPTLSVPGNLSSSRSTRHHFSHWEPIPIFSSACNCPALATVAYPCWATDALQRCNFEELHSFVCWTSAARGCPTPTRQCDALYSPTPLTGKHPCDLGQNTGGLEPPQDTTVYITETSYVTFVPTETATAAVGARAAATPLGRWQDMAWSPEYYGVRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BYB3</accession>
    <name>A0A177BYB3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1168979</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441560">
        <property type="protein sequence ID" value="OAG00126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030491.1">
        <property type="nucleotide sequence ID" value="XM_018179544.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BYB3"/>
    <dbReference type="GeneID" id="28763030"/>
    <dbReference type="InParanoid" id="A0A177BYB3"/>
    <dbReference type="OrthoDB" id="10431526at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG00126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="238" mass="27592" checksum="7BFBB09FCA8AAA19" modified="2016-09-07" version="1" fragment="single">MLNIFSSLTKNGWRETFRILRHSENIIRKQPSSPRKKYVHVRRRDRKGRKMRAAFQLVEEQGGDGTGRTYRRVNDGWEVGEGEVQEIILEKKTVVSMDANGNSQRLDRRKTTNRKRKVRAEGRELRVGGCCPTFLPSHTQLVWLVRWLNSFLGDSINKQDRKAKTPPTGTQIQWRTTVYANSVTTSIQRRELERRGVALLEAKGSQSEDYSPERNVKKEPSQHFRPKRSNKSFLTAGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BZM1</accession>
    <name>A0A177BZM1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1168725</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441559">
        <property type="protein sequence ID" value="OAG00665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031030.1">
        <property type="nucleotide sequence ID" value="XM_018179466.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BZM1"/>
    <dbReference type="GeneID" id="28762952"/>
    <dbReference type="InParanoid" id="A0A177BZM1"/>
    <dbReference type="OrthoDB" id="10250105at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG00665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="50" mass="5535" checksum="26CCB6A0D8927EE3" modified="2016-09-07" version="1" fragment="single">MLENSPARFDVNFAGPKDSDVDEDSLKDVKVFTFPGGPGKLPLRRRNTSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C0H3</accession>
    <name>A0A177C0H3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Fructosyl amino acid oxidasesarcosine oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_1152973</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MSOX/MTOX family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441557">
        <property type="protein sequence ID" value="OAG01294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031659.1">
        <property type="nucleotide sequence ID" value="XM_018176825.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C0H3"/>
    <dbReference type="STRING" id="1460663.A0A177C0H3"/>
    <dbReference type="GeneID" id="28760311"/>
    <dbReference type="InParanoid" id="A0A177C0H3"/>
    <dbReference type="OrthoDB" id="2219495at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051698">
        <property type="term" value="F:saccharopine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008115">
        <property type="term" value="F:sarcosine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045170">
        <property type="entry name" value="MTOX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10961:SF37">
        <property type="entry name" value="FAD DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10961">
        <property type="entry name" value="PEROXISOMAL SARCOSINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="7">
        <location>
            <begin position="10"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="424"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAG01294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="452" mass="51014" checksum="75ABA00976D67120" modified="2016-09-07" version="1">MAQEDQSPSLLIIGAGTFGTSLAVHASKSYPDASKITIVDRWCPDGAVQDKNAAAIDINRIIRTDYTSPLYCNLANEAIHFWFWNMEVQGHFHKAGWTVFDGPRQEREFRDGVRKTFEDRGSHIIRNVDADKLIKEHDVLKGLNGADLGNGYFNPEAGWVNAAKATKAYLRVAESRGVQRITGEVEELLFRDGDTGLEGVRLQDGTILRADKVVIAAGAWTSGLLSPLEDKLNIADKDRIERQVTAVGRLSAYFDLSEEETNYMMDTNLPIVVIGGEVDIIPPYYHIPTLKVNDLRTEFTNTITTASGRKITTPSKKNQMHVPRRLIQESEKVVKSSMPEWTKARSPDRWRICYDAVTPTEDWVLSRHPDDRLGNLYIAVGGSFHSYKFMPNAGKYLLNVLNGESNGEEKDRAWKWKSEEELKERGAKEFGESPRNGNRPELRDFEEEKARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C0M4</accession>
    <name>A0A177C0M4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1180411</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441559">
        <property type="protein sequence ID" value="OAG00392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030757.1">
        <property type="nucleotide sequence ID" value="XM_018180474.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C0M4"/>
    <dbReference type="GeneID" id="28763960"/>
    <dbReference type="InParanoid" id="A0A177C0M4"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG00392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="272" mass="29000" checksum="332542E470A6C602" modified="2016-09-07" version="1">MPGGAKRPGGDRTTHPALERELLQPRPGTASSACRLSTVARRQPRFLCDPERAAPAAPGATTAARQAARGVVVVDVVVLGRRQRAAPGREGVWDGGARQKTATDGPGACGRVCMRGQRAFQPGCMGKLHPRRAFPHDPHPLLPLPRRLPVLTSSSHAASRSASCSDLSRCTESIVGTANAAPSQHLASTQPAPSRRPASSFARTAADMHITQTFTSSRRVTARHPAAPWQLHPRTRVPHPRTCPPHWERGLPAARDGAHATSWTADLHLTDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C0N7</accession>
    <name>A0A177C0N7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1263042</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441558">
        <property type="protein sequence ID" value="OAG00976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031341.1">
        <property type="nucleotide sequence ID" value="XM_018185201.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C0N7"/>
    <dbReference type="GeneID" id="28768687"/>
    <dbReference type="InParanoid" id="A0A177C0N7"/>
    <dbReference type="OrthoDB" id="3782642at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008057629" evidence="1">
        <location>
            <begin position="19"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG00976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="279" mass="29881" checksum="DAE61946252B876B" modified="2016-09-07" version="1">MKLFQLVTAFAVTAFTVATSPGSGDESPARRASVARQAVNDLAARNPGAVSHYSHILAYYKKGFTSRDEDHENIPELAEAAGDSCSDWKQKYKKTQCARPWAPECEWDCAAKLCKDGPSECHKGGALGPKYCGSRANGHTSSGSSVTLLVRQDDQHTNEANEKKTETTAGCDQCDSWMNDCKSKCPHPNRPECRWKCLAALCAGRGPAECRGGAACGSASGCLKDAGSSNAPQARDDGDGWDEEECNEYTTGCVDAFCRDPLHNGPNSCSHKVKSFSLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C0S6</accession>
    <name>A0A177C0S6_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1209103</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441558">
        <property type="protein sequence ID" value="OAG01016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031381.1">
        <property type="nucleotide sequence ID" value="XM_018182200.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C0S6"/>
    <dbReference type="GeneID" id="28765686"/>
    <dbReference type="InParanoid" id="A0A177C0S6"/>
    <dbReference type="OrthoDB" id="10327567at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCHC-type" evidence="1">
        <location>
            <begin position="130"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="1">
        <location>
            <begin position="271"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="1">
        <location>
            <begin position="312"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="1">
        <location>
            <begin position="353"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG01016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="370" mass="40405" checksum="173C7C90BB2E0866" modified="2016-09-07" version="1">MASTSSTKHHHIKDTPLSGCGCIDCIMSLPWLPAVPPEQQHDNGLLPSAAPVSRIPDGILGSAQNATKEMVAQLLNKQNNSEADHEAGQRITTRDRTVSYQANNPDEVCRYFNTGIDCASWLSHCQRAHICSNCQSTTHGAHGCTFNPSSLIKGSYMTSANPTPTSHQQPLAREQVVMCATSPPDGPLSTTTNLVTIPQALTAAELTMYPIPPPRAPFSDPRTGMPMYFVPTSFNPSWISSDTTPNRPTRICELHNRTSGCTWSECHRQHICSNCHSPNHTLPACTNYPNHVCEKFNSECGCLFLHCQRRHVCSNCHSSAHSVFLCSNYPDFVCEKFNGTAGCLWVGCKRRHVCGKCGKEGHGQAVCEGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C126</accession>
    <name>A0A177C126_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1168635</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441559">
        <property type="protein sequence ID" value="OAG00542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030907.1">
        <property type="nucleotide sequence ID" value="XM_018179447.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C126"/>
    <dbReference type="STRING" id="1460663.A0A177C126"/>
    <dbReference type="GeneID" id="28762933"/>
    <dbReference type="InParanoid" id="A0A177C126"/>
    <dbReference type="OrthoDB" id="4226666at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052973">
        <property type="entry name" value="Fungal_sec-metab_reg_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35392:SF1">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35392">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="256"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="361"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="53"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="278"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="361"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG00542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="889" mass="100269" checksum="452BA5A5B711A1CA" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C1C4</accession>
    <name>A0A177C1C4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Amino acid transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CC84DRAFT_1230772</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441559">
        <property type="protein sequence ID" value="OAG00598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030963.1">
        <property type="nucleotide sequence ID" value="XM_018183705.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C1C4"/>
    <dbReference type="STRING" id="1460663.A0A177C1C4"/>
    <dbReference type="GeneID" id="28767191"/>
    <dbReference type="InParanoid" id="A0A177C1C4"/>
    <dbReference type="OrthoDB" id="2417308at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF14">
        <property type="entry name" value="GABA PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="41"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="70"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="165"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="193"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="240"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="273"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="327"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="374"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="402"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="447"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="478"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAG00598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="518" mass="56119" checksum="D6702466E5403BA8" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C1S5</accession>
    <name>A0A177C1S5_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">4-aminobutyrate aminotransferase</fullName>
            <ecNumber evidence="3">2.6.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">GABA aminotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Gamma-amino-N-butyrate transaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CC84DRAFT_216207</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>4-aminobutanoate + 2-oxoglutarate = succinate semialdehyde + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:23352"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57706"/>
            <dbReference type="ChEBI" id="CHEBI:59888"/>
            <dbReference type="EC" id="2.6.1.19"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.19" evidence="3"/>
    <dbReference type="EMBL" id="KV441557">
        <property type="protein sequence ID" value="OAG01734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032099.1">
        <property type="nucleotide sequence ID" value="XM_018185611.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C1S5"/>
    <dbReference type="FunCoup" id="A0A177C1S5">
        <property type="interactions" value="273"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177C1S5"/>
    <dbReference type="GeneID" id="28769097"/>
    <dbReference type="InParanoid" id="A0A177C1S5"/>
    <dbReference type="OrthoDB" id="10260828at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034386">
        <property type="term" value="F:4-aminobutyrate:2-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009450">
        <property type="term" value="P:gamma-aminobutyric acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000029">
        <property type="entry name" value="4-aminobutyrate aminotransferase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004631">
        <property type="entry name" value="4NH2But_aminotransferase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00699">
        <property type="entry name" value="GABAtrns_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43206:SF1">
        <property type="entry name" value="4-AMINOBUTYRATE AMINOTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43206">
        <property type="entry name" value="AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="7 11" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OAG01734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="513" mass="56426" checksum="8B50E1CF1F5CCC54" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C237</accession>
    <name>A0A177C237_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1167726</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441557">
        <property type="protein sequence ID" value="OAG01516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031881.1">
        <property type="nucleotide sequence ID" value="XM_018179246.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C237"/>
    <dbReference type="GeneID" id="28762732"/>
    <dbReference type="InParanoid" id="A0A177C237"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG01516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="51" mass="4880" checksum="25E81B48E551E97F" modified="2016-09-07" version="1">MSSASTPSNTSTAGASSGSNPSYQLPYAPFPYPMPANGGSGQQGGKGGSGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C2Q6</accession>
    <name>A0A177C2Q6_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ubiquitin-conjugating enzyme E2 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">E2 ubiquitin-conjugating enzyme 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Ubiquitin carrier protein UBC2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Ubiquitin-protein ligase UBC2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CC84DRAFT_1128644</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="8">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441558">
        <property type="protein sequence ID" value="OAG01179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031544.1">
        <property type="nucleotide sequence ID" value="XM_018175806.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C2Q6"/>
    <dbReference type="FunCoup" id="A0A177C2Q6">
        <property type="interactions" value="405"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177C2Q6"/>
    <dbReference type="GeneID" id="28759292"/>
    <dbReference type="InParanoid" id="A0A177C2Q6"/>
    <dbReference type="OrthoDB" id="10253686at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23791">
        <property type="entry name" value="UBCc_UBE2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 8" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="9">
        <location>
            <begin position="16"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="7">
        <location>
            <position position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00039884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00041569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00042179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00042190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAG01179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="168" mass="18495" checksum="2CC115B5D7283CE4" modified="2016-09-07" version="1">MALSTGARTNGSGGATVAQRLQKELMDIMMKPTPGITAFPDDENMSRWTATIDGPESTPYENLVFKLSMEFGATYPYAPPTVLFKTPIYHPNVDFSGRICLDILKDKWSAVYNIGTVLLSLQSLLGEPNNSSPLNGQAAELWDKDMDEFKRLVLARHKTPEELDAAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C3M0</accession>
    <name>A0A177C3M0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1221779</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441558">
        <property type="protein sequence ID" value="OAG01260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031625.1">
        <property type="nucleotide sequence ID" value="XM_018183302.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C3M0"/>
    <dbReference type="GeneID" id="28766788"/>
    <dbReference type="InParanoid" id="A0A177C3M0"/>
    <dbReference type="OrthoDB" id="3798255at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="42"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG01260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="98" mass="10638" checksum="D524B380AA95FD2C" modified="2016-09-07" version="1">MGQGHSHSAPERPPTAPQEPERELDPEERARIQAEERERRAAAVQARLAGQQKRSGNGNGVGAGAGGTKKKPSALEQMSAENRGWRAADEQAELRSWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C422</accession>
    <name>A0A177C422_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphate transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CC84DRAFT_1152571</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Sodium-phosphate symporter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441556">
        <property type="protein sequence ID" value="OAG02245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032610.1">
        <property type="nucleotide sequence ID" value="XM_018176807.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C422"/>
    <dbReference type="FunCoup" id="A0A177C422">
        <property type="interactions" value="962"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177C422"/>
    <dbReference type="GeneID" id="28760293"/>
    <dbReference type="InParanoid" id="A0A177C422"/>
    <dbReference type="OrthoDB" id="260807at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005436">
        <property type="term" value="F:sodium:phosphate symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035435">
        <property type="term" value="P:phosphate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001204">
        <property type="entry name" value="Phos_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11101">
        <property type="entry name" value="PHOSPHATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11101:SF55">
        <property type="entry name" value="PHOSPHATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01384">
        <property type="entry name" value="PHO4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="46"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="151"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="186"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="223"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="469"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="507"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="556"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="296"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="297"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAG02245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="586" mass="63142" checksum="7011A8DD891C2D39" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C578</accession>
    <name>A0A177C578_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1220404</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441556">
        <property type="protein sequence ID" value="OAG02039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032404.1">
        <property type="nucleotide sequence ID" value="XM_018183164.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C578"/>
    <dbReference type="STRING" id="1460663.A0A177C578"/>
    <dbReference type="GeneID" id="28766650"/>
    <dbReference type="InParanoid" id="A0A177C578"/>
    <dbReference type="OrthoDB" id="10261384at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11960">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034627">
        <property type="entry name" value="Irc6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28043">
        <property type="entry name" value="INCREASED RECOMBINATION CENTERS PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28043:SF1">
        <property type="entry name" value="INCREASED RECOMBINATION CENTERS PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG02039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="263" mass="29011" checksum="1E34C0E9E2ABF217" modified="2016-09-07" version="1">MEISNPRRILAVGAPGSGVLSLLKDLTGSAPELITDTTAGLSHEWNLTTKYYTAKLPIWIDEIPDIAEWRTEFTKPEAKEVVTAIGAWIFCFKKPVTEKDVEAIKDTMAAIAKVVEAACGYSDDHVRLAVAMPQSITPYLEKGAEDWDDVCMEHGFEFVDSEAKGKNQYGEEMGVKRVEDALKAQEWDGIGADDDFGFDDDAFGEGLDAEEREMGMELFGLKNAVHGMGEDEEAQVEELEGLMRKMVAIKGIYNLHASAHTRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C5L7</accession>
    <name>A0A177C5L7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">LDB19 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1021195</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441556">
        <property type="protein sequence ID" value="OAG02441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032806.1">
        <property type="nucleotide sequence ID" value="XM_018173385.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C5L7"/>
    <dbReference type="FunCoup" id="A0A177C5L7">
        <property type="interactions" value="20"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177C5L7"/>
    <dbReference type="GeneID" id="28756871"/>
    <dbReference type="InParanoid" id="A0A177C5L7"/>
    <dbReference type="OrthoDB" id="3832628at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070086">
        <property type="term" value="P:ubiquitin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050357">
        <property type="entry name" value="Arrestin_domain-protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024391">
        <property type="entry name" value="LDB19_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188">
        <property type="entry name" value="ARRESTIN DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188:SF76">
        <property type="entry name" value="PROTEIN LDB19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13002">
        <property type="entry name" value="LDB19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LDB19 N-terminal" evidence="2">
        <location>
            <begin position="131"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="414"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="441"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG02441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="453" mass="50285" checksum="92EEC0BAB44FAB66" modified="2016-09-07" version="1">MPGRLLSLVRPAPASSPPLDQLKGQKKHSDIPPLFPPVYSVERPSQKNKSQESLVMEAFKRHGLGGRQNSFKKSPKASPKAEPQPAAILNMVVESPPLVFFNSPQTSTGAIISGLLNLEVHEPNVTLEKMEMRLLAVVTTKKPVHQHCPDCTSQTTEIHKWEFLRGAVQLHFGQHSFPFSHLIPGHLPATTHGQITTLDYYLDAVGTLSNGKKLEYKRALDIKRSIVPGPDKHSIRIFPPTNLTASVKLPPVVHPIGDFGVEMRLSGVTQTKDDSQSRWRLRKLNWRIEETQKSISPACPKHANKVGGEGKGILHDDTRTIASEEVKTGWKTDFTEGNIDCEFRARCNIAHNPLCDMDSQSGMSVRHNLVIEMVVAEEWAPLKKLSQATPTGAARVLRTQFHLVLTERSGMGISWDEEQPPLYEDVPASPPTYIGDYDGPPLHDEHDELHLGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C5P1</accession>
    <name>A0A177C5P1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative hydroxybutyrate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CC84DRAFT_1262033</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441556">
        <property type="protein sequence ID" value="OAG02000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032365.1">
        <property type="nucleotide sequence ID" value="XM_018185120.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C5P1"/>
    <dbReference type="STRING" id="1460663.A0A177C5P1"/>
    <dbReference type="GeneID" id="28768606"/>
    <dbReference type="InParanoid" id="A0A177C5P1"/>
    <dbReference type="OrthoDB" id="2102561at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000140">
        <property type="term" value="F:acylglycerone-phosphate reductase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019433">
        <property type="term" value="P:triglyceride catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05374">
        <property type="entry name" value="17beta-HSD-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44169">
        <property type="entry name" value="NADPH-DEPENDENT 1-ACYLDIHYDROXYACETONE PHOSPHATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44169:SF6">
        <property type="entry name" value="NADPH-DEPENDENT 1-ACYLDIHYDROXYACETONE PHOSPHATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAG02000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="272" mass="29184" checksum="68BCA70EABABE1F6" modified="2016-09-07" version="1">MAKAVLITGCSDGGIGHALAKSFAQRGLTVFATARLVSNITGFEQFPSIHLLQLDVIDPNSIKAAVEAVEARSGRLDYLVNNAGRGYFMPAMGADIEESKKVYEVNFWGPLRTTQAFMPLLIASKGSIVNIGSIVGYFSQPYIGIYSASKAALHSLSDIMRVELAPFSVKVLTVVTGSIKTALHGKLPPCQLPEGSIYAPIQQQLDIMAHSDSIVRSEAEPYAEAVVSDVLAGKTGRVWHGSNSWKTKAGKILPKRVQDRILCKGAGLERLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C5S0</accession>
    <name>A0A177C5S0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1099398</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441556">
        <property type="protein sequence ID" value="OAG02030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032395.1">
        <property type="nucleotide sequence ID" value="XM_018174821.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C5S0"/>
    <dbReference type="STRING" id="1460663.A0A177C5S0"/>
    <dbReference type="GeneID" id="28758307"/>
    <dbReference type="InParanoid" id="A0A177C5S0"/>
    <dbReference type="OrthoDB" id="5229512at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG02030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="484" mass="55534" checksum="468383D1E870E564" modified="2016-09-07" version="1">MDHVSIDIDEESEDEALTSEVLAAFDKLHEQLRRHRALVVQPAVPRQPFPFMRLPLELREQVYDEYFRPENRLELYEAGEGIGGMYNFEFTLLRTSKQVYREALRSWRKNVFVRIETPWPHAVHHIRSEGQVPIVAAGPRALKCFQHRALVQITAPLHGVTVPDHAIVLLLEDVSKFTRVWYYSALNYVSLNPQLCLIFALREPYTPRDPKPVPLELQRKLLLPFGDVKDLYDTQMTGYDESVIAELRKAMKVPYPTVRESCELATTLMDEGDLFLATNQPQLAHISYIKSFDAIHIKISGRNRRILADGHFADDIHEGRYAGQAAMTVRVVLRIRLVTRMIRTYIHLGQPNEAAFWGIRSIKLVRQGLSPNADMDDFYSDFIGSSDIAMIYAWTAGAFQLMEAEEQWKEEIEGYAWEDGGVADTEVMWRRAGLYLASERYAGERKGMVEEMRRVGIKPPAGVFTDEASEIDSMRHMDMGDVES</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C656</accession>
    <name>A0A177C656_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Tat pathway signal sequence</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CC84DRAFT_1097786</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Mycotoxin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ustYa family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG02621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032986.1">
        <property type="nucleotide sequence ID" value="XM_018174731.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C656"/>
    <dbReference type="STRING" id="1460663.A0A177C656"/>
    <dbReference type="GeneID" id="28758217"/>
    <dbReference type="InParanoid" id="A0A177C656"/>
    <dbReference type="OrthoDB" id="3687641at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021765">
        <property type="entry name" value="UstYa-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365:SF11">
        <property type="entry name" value="TAT PATHWAY SIGNAL SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365">
        <property type="entry name" value="YALI0B05434P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11807">
        <property type="entry name" value="UstYa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00035112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAG02621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="205" mass="23178" checksum="D7FA7C1A152575A6" modified="2016-09-07" version="1">MKGPFWKTVTSHFFFTLLGILFGIAWSYWPVGGFSNDGYLSPSGHTPEVWSSENFTFTGEPSALTQSAWASLIPKGKGFVEHPHIASPPKAVAAYHQIHCLHGIRIAYYSRVNELHKLQGKHSLINHYIENMGGERGLYHLDHCFEYLRHALMCAADSNLEDLVVDEETGTAVAPGWGTKRVCRDFERLGKWSERWRASEDETIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C670</accession>
    <name>A0A177C670_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Jacalin-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1261846</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG03254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033619.1">
        <property type="nucleotide sequence ID" value="XM_018185104.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C670"/>
    <dbReference type="GeneID" id="28768590"/>
    <dbReference type="InParanoid" id="A0A177C670"/>
    <dbReference type="OrthoDB" id="3758675at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.15.10">
        <property type="entry name" value="Proaerolysin, chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56973">
        <property type="entry name" value="Aerolisin/ETX pore-forming domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008057763" description="Jacalin-type lectin domain-containing protein" evidence="1">
        <location>
            <begin position="26"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG03254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="376" mass="41096" checksum="A18EA8B115E8983B" modified="2016-09-07" version="1">MIIPSSRLLCGAALALTTLFSTVDAADCSTGPFAHVWKIGDSKAGENTDNVEFCSSLWDVGIPVTGLDVWYDEGEGINALQIQYANGDRHGIFGVPGSSPQHQSIDWEYSKTFIDSFSLWGNGGGKKLGNIRMVLTDGREFDVGNRHDTRSKKTEFPIDVGAGVMLGFGGWGANDIKQGYALFLRSQIDHITMTDPVFDESPENLNAQQKGIELQIVDSYDHANDLNATINWSFETTASVHTSTSTTTSVTKTFGTSVSVNWEASILAFSVGGGVELSYGYSQTNEKVETKETEVSRTITYEAPIKPGKHVWCQATAKSGKADLGYTATINLWLKDGTSWSWKEHGVYSQQAWGDTSSQCQEKPFSNARRSVEWHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C6A3</accession>
    <name>A0A177C6A3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Succinate-CoA ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CC84DRAFT_1099489</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441556">
        <property type="protein sequence ID" value="OAG02220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032585.1">
        <property type="nucleotide sequence ID" value="XM_018174828.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C6A3"/>
    <dbReference type="STRING" id="1460663.A0A177C6A3"/>
    <dbReference type="GeneID" id="28758314"/>
    <dbReference type="InParanoid" id="A0A177C6A3"/>
    <dbReference type="OrthoDB" id="1664372at2759"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER00999"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009361">
        <property type="term" value="C:succinate-CoA ligase complex (ADP-forming)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004775">
        <property type="term" value="F:succinate-CoA ligase (ADP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004776">
        <property type="term" value="F:succinate-CoA ligase (GDP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000277">
        <property type="entry name" value="Succinate--CoA ligase [ADP-forming] subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017440">
        <property type="entry name" value="Cit_synth/succinyl-CoA_lig_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033847">
        <property type="entry name" value="Citrt_syn/SCS-alpha_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005810">
        <property type="entry name" value="CoA_lig_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005811">
        <property type="entry name" value="SUCC_ACL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004230">
        <property type="entry name" value="PRK05678.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11117">
        <property type="entry name" value="SUCCINYL-COA LIGASE SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11117:SF6">
        <property type="entry name" value="SYNTHETASE SUBUNIT ALPHA, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G10830)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02629">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00549">
        <property type="entry name" value="Ligase_CoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001553">
        <property type="entry name" value="SucCS_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01798">
        <property type="entry name" value="SCOASYNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00881">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01216">
        <property type="entry name" value="SUCCINYL_COA_LIG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00399">
        <property type="entry name" value="SUCCINYL_COA_LIG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 6" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="CoA-binding" evidence="5">
        <location>
            <begin position="31"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="4">
        <location>
            <position position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR001553-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAG02220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="323" mass="34125" checksum="AE38AD2DD761A980" modified="2016-09-07" version="1">MLRQHCRQRGLASTSIRRYASHGDNTIANLRINQHTPVIYQGFTGKAATSNAKDTIAYATNVVGGVSPGKGGRDHLGLPVFNTVREAKDALDPHATCVFVPAMHAAGAIIEAIEAEIPLVVSVAEHIPVHDMLRVHEVLRTQSRTRLVGPNCPGIIAPEQCRLGIMPYKQYLKGCVGIVSKSGTLSYEAVGATTNAGLGQSIVVGMGGDMLPGTTLVDGLRLFFDHPETEGIIVIGEVGGEAELNAAELVKEYRSRTENPKPIIAMVAGRTAPEGKTMGHAGALLSPRDATAEAKAKALEEAGAVVVPHPGLMGSEMRRLLGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C6X4</accession>
    <name>A0A177C6X4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DUF3176 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1198567</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441556">
        <property type="protein sequence ID" value="OAG02450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032815.1">
        <property type="nucleotide sequence ID" value="XM_018181575.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C6X4"/>
    <dbReference type="STRING" id="1460663.A0A177C6X4"/>
    <dbReference type="GeneID" id="28765061"/>
    <dbReference type="InParanoid" id="A0A177C6X4"/>
    <dbReference type="OrthoDB" id="5242705at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021514">
        <property type="entry name" value="DUF3176"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35394">
        <property type="entry name" value="DUF3176 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35394:SF5">
        <property type="entry name" value="DUF3176 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11374">
        <property type="entry name" value="DUF3176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="194"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="701"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="799"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG02450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="827" mass="93071" checksum="03D3B9653E8E9910" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C7F0</accession>
    <name>A0A177C7F0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_841056</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG03475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033840.1">
        <property type="nucleotide sequence ID" value="XM_018187620.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C7F0"/>
    <dbReference type="STRING" id="1460663.A0A177C7F0"/>
    <dbReference type="GeneID" id="28771106"/>
    <dbReference type="InParanoid" id="A0A177C7F0"/>
    <dbReference type="OrthoDB" id="3936275at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="177"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="255"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="324"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="413"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="443"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="540"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="22"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="65"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="112"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="268"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="422"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="453"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="481"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG03475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="582" mass="61733" checksum="A1E5F95F9FB631FC" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C7G3</accession>
    <name>A0A177C7G3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1166602</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG02792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033157.1">
        <property type="nucleotide sequence ID" value="XM_018179003.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C7G3"/>
    <dbReference type="GeneID" id="28762489"/>
    <dbReference type="InParanoid" id="A0A177C7G3"/>
    <dbReference type="OrthoDB" id="5342924at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG02792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="55" mass="6004" checksum="A71BAD3DD89A2330" modified="2016-09-07" version="1">MRCDHSLNIGTAPLSLSIRQPVGIRVNDLDGLELVFANDKDVDHTIFGKVEPSKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C7G5</accession>
    <name>A0A177C7G5_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein regulator of cytokinesis 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_920149</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG02799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033164.1">
        <property type="nucleotide sequence ID" value="XM_018187891.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C7G5"/>
    <dbReference type="STRING" id="1460663.A0A177C7G5"/>
    <dbReference type="GeneID" id="28771377"/>
    <dbReference type="InParanoid" id="A0A177C7G5"/>
    <dbReference type="OrthoDB" id="642895at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990023">
        <property type="term" value="C:mitotic spindle midzone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051256">
        <property type="term" value="P:mitotic spindle midzone assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1520">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007145">
        <property type="entry name" value="MAP65_Ase1_PRC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19321:SF41">
        <property type="entry name" value="FASCETTO-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19321">
        <property type="entry name" value="PROTEIN REGULATOR OF CYTOKINESIS 1 PRC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03999">
        <property type="entry name" value="MAP65_ASE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="383"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="462"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="692"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="43"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="224"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="399"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="483"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="508"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="555"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="603"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="628"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="646"/>
            <end position="672"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG02799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="752" mass="85458" checksum="96D9BB28F759FDE7" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C7K4</accession>
    <name>A0A177C7K4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_934304</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG02832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033197.1">
        <property type="nucleotide sequence ID" value="XM_018187901.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C7K4"/>
    <dbReference type="GeneID" id="28771387"/>
    <dbReference type="InParanoid" id="A0A177C7K4"/>
    <dbReference type="OrthoDB" id="10379727at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG02832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="350" mass="38723" checksum="EB0936782C9321BA" modified="2016-09-07" version="1">MVIKMARRSRSSPPTAQSEIDKYNTIKSHRRLGFTFDELEMLYFGEEGRGFPEPLRVTQRIWKNQRTFHGVLEVLKRYANKRPEEVRVSIRNFENQRETERRMRQLAEATERLAQAIMGPIPGELPMDQPQQGGFASNFGDQHPFGPQPGYQWKGPIMGNTAVPGPFMHGQMAQANGAAGNLLPLGVNAGLVDAFEHPATLTAQDNLHGGTPTPMELTPAERCDWLPEVPSDTRLIAPALTPDVSSREMSFDAIFPEKSPDSPLLPAENLNEEQSLGDSFALSSLEYELSNRGSSSNALDTAGFNLFDDLFTTESSSHKLDTIDINTFDEQDSLIMEAIGDTRGAGTKSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C7L7</accession>
    <name>A0A177C7L7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">25S rRNA (Uridine(2843)-N(3))-methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1188870</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG02768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033133.1">
        <property type="nucleotide sequence ID" value="XM_018181016.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C7L7"/>
    <dbReference type="FunCoup" id="A0A177C7L7">
        <property type="interactions" value="34"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177C7L7"/>
    <dbReference type="GeneID" id="28764502"/>
    <dbReference type="InParanoid" id="A0A177C7L7"/>
    <dbReference type="OrthoDB" id="6419443at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021463">
        <property type="entry name" value="Methyltransf_34"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11312">
        <property type="entry name" value="Methyltransf_34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG02768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="328" mass="36605" checksum="365B0B267B36A815" modified="2016-09-07" version="1">MQFINTGTLPGKAIEQQLLLNIFRDAFPERLSTDIKPLLQEVKGHLYNRDFATAFGKEEYLETYALRWSPSRTLCYLEILHDLRDELKPFESESEETEDAEWKIVGLGGGAGAEIVALGGLMKLLKTTEEEHRAKMNIAAIDIADWANVVTRLGSGIVTKPPLSKYASAAAQSANSALTSLSSFAVTFHQHDVLNLSPDTLANIVENAHLITLLFTLNELYTTSLSLTQKFLLNLTTALAPGAHLLVVDSPGSYSTVSLNGAERKYPMQWLLDHTLLNPSGDAKANPSPCWEKLQEEESKWFRLPAGLRYPIELENMRYQLHLYRRCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C800</accession>
    <name>A0A177C800_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1260862</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG03773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034138.1">
        <property type="nucleotide sequence ID" value="XM_018185019.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C800"/>
    <dbReference type="GeneID" id="28768505"/>
    <dbReference type="InParanoid" id="A0A177C800"/>
    <dbReference type="OrthoDB" id="5139479at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="201"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="532"/>
            <end position="556"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG03773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="629" mass="68205" checksum="C07ADBF38B2A956D" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C839</accession>
    <name>A0A177C839_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_1188933</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG02860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033225.1">
        <property type="nucleotide sequence ID" value="XM_018181023.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C839"/>
    <dbReference type="STRING" id="1460663.A0A177C839"/>
    <dbReference type="GeneID" id="28764509"/>
    <dbReference type="InParanoid" id="A0A177C839"/>
    <dbReference type="OrthoDB" id="4898680at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF40">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="3">
        <location>
            <begin position="233"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAG02860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="606" mass="68386" checksum="3F6B9C5C8BA5618F" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C841</accession>
    <name>A0A177C841_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Endoglucanase IV</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CC84DRAFT_1260889</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG03813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034178.1">
        <property type="nucleotide sequence ID" value="XM_018185023.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C841"/>
    <dbReference type="STRING" id="1460663.A0A177C841"/>
    <dbReference type="GeneID" id="28768509"/>
    <dbReference type="InParanoid" id="A0A177C841"/>
    <dbReference type="OrthoDB" id="4849160at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd21175">
        <property type="entry name" value="LPMO_AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049892">
        <property type="entry name" value="AA9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005103">
        <property type="entry name" value="AA9_LPMO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353:SF34">
        <property type="entry name" value="ENDO-BETA-1,4-GLUCANASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03443">
        <property type="entry name" value="AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008057844" evidence="5">
        <location>
            <begin position="17"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="Auxiliary Activity family 9 catalytic" evidence="6">
        <location>
            <begin position="17"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAG03813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="253" mass="26651" checksum="1EBCBD7D13EE2972" modified="2016-09-07" version="1">MRSAVLLAALPALVSAHGHVEQVKADGVLYQGWNAAFQYQNPVPKTVGWKADNLDNGFVSPDAFATSAIVCHKQGASNGAYVNVKAGSTATFYWDTWPVTHKGPVIDYIAACNGDCGAVASTSLSWTKLDQKGWLSGSNPGTWATDNLIAANNTWTITIPSNLASGNYVVRHEIIALHAAGSTNGAQAYPQCVNFAVTGSGSAKPQGGVPATSFYKASDPGILFNLYTAFTSYTIPGPALGKIAKREHAREFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C935</accession>
    <name>A0A177C935_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Protein DML1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_1166269</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the partitioning of the mitochondrial organelle and mitochondrial DNA (mtDNA) inheritance.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the misato family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG04163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034528.1">
        <property type="nucleotide sequence ID" value="XM_018178915.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C935"/>
    <dbReference type="FunCoup" id="A0A177C935">
        <property type="interactions" value="79"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177C935"/>
    <dbReference type="GeneID" id="28762401"/>
    <dbReference type="InParanoid" id="A0A177C935"/>
    <dbReference type="OrthoDB" id="271881at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049942">
        <property type="entry name" value="DML1/Misato"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029209">
        <property type="entry name" value="DML1/Misato_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019605">
        <property type="entry name" value="Misato_II_tubulin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13391">
        <property type="entry name" value="MITOCHONDRIAL DISTRIBUTION REGULATOR MISATO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13391:SF0">
        <property type="entry name" value="PROTEIN MISATO HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10644">
        <property type="entry name" value="Misat_Tub_SegII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14881">
        <property type="entry name" value="Tubulin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Misato Segment II tubulin-like" evidence="6">
        <location>
            <begin position="2"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="DML1/Misato tubulin" evidence="7">
        <location>
            <begin position="120"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="355"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF10644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAG04163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="520" mass="58134" checksum="1A873996FCB62879" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C9P2</accession>
    <name>A0A177C9P2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">FAD-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CC84DRAFT_1217770</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG04295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034660.1">
        <property type="nucleotide sequence ID" value="XM_018182928.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C9P2"/>
    <dbReference type="STRING" id="1460663.A0A177C9P2"/>
    <dbReference type="GeneID" id="28766414"/>
    <dbReference type="InParanoid" id="A0A177C9P2"/>
    <dbReference type="OrthoDB" id="9983560at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF39">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="6">
        <location>
            <begin position="1"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAG04295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="360" mass="38765" checksum="BC40168094053CE7" modified="2016-09-07" version="1">MGGYPSYSVNVSTVAQVQLAINFARNTGVRLLVHNTGHDYLGKSTGANALSIWTRHLNSIEFIANYAGASAHIGSAFKMGAGTQTWELLQAAHEEDVSVLTGECPTVGVAGGYIAGGGMRPLSSKYGLAVDHVLSIDVVTPDGKFFTVDEKNNTDLFWALRGGGGGAFGVVTSVTVSTLPKLKMAGLTLSITIGPNGDVSDDIFWQAIDGQMSWALTPWIVPDMSLDEFKAMTADLRVQWEKLKFNVPLNFFETDNFYEAWTTHFPDDTVGVPNLRTASRLIDDQNWVNPSLLNDTIAFVQRVINNGSSLIGYNIRAATVADAPASATVPIWRDATMFAIVGTMWDAVPEIGQIITNTVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CAC4</accession>
    <name>A0A177CAC4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">CNH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CC84DRAFT_1207279</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG04081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034446.1">
        <property type="nucleotide sequence ID" value="XM_018182089.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CAC4"/>
    <dbReference type="STRING" id="1460663.A0A177CAC4"/>
    <dbReference type="GeneID" id="28765575"/>
    <dbReference type="InParanoid" id="A0A177CAC4"/>
    <dbReference type="OrthoDB" id="5325112at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034058">
        <property type="term" value="P:endosomal vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001180">
        <property type="entry name" value="CNH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032914">
        <property type="entry name" value="Vam6/VPS39/TRAP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12894">
        <property type="entry name" value="CNH DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12894:SF27">
        <property type="entry name" value="TRANSFORMING GROWTH FACTOR-BETA RECEPTOR-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50219">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="CNH" evidence="6">
        <location>
            <begin position="39"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="239"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="279"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="324"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAG04081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="1172" mass="129217" checksum="B44D77BB81F25FC6" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CAS6</accession>
    <name>A0A177CAS6_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Carboxypeptidase</fullName>
            <ecNumber evidence="13">3.4.16.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CC84DRAFT_867442</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Vacuolar carboxypeptidase involved in degradation of small peptides. Digests preferentially peptides containing an aliphatic or hydrophobic residue in P1' position, as well as methionine, leucine or phenylalanine in P1 position of ester substrate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>Release of a C-terminal amino acid with broad specificity.</text>
            <dbReference type="EC" id="3.4.16.5"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the peptidase S10 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.-" evidence="13"/>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG03800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034165.1">
        <property type="nucleotide sequence ID" value="XM_018187716.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CAS6"/>
    <dbReference type="FunCoup" id="A0A177CAS6">
        <property type="interactions" value="860"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CAS6"/>
    <dbReference type="GeneID" id="28771202"/>
    <dbReference type="InParanoid" id="A0A177CAS6"/>
    <dbReference type="OrthoDB" id="443318at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000328">
        <property type="term" value="C:fungal-type vacuole lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.410:FF:000001">
        <property type="entry name" value="Carboxypeptidase Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008442">
        <property type="entry name" value="Propeptide_carboxypepY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018202">
        <property type="entry name" value="Ser_caboxypep_ser_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF113">
        <property type="entry name" value="SERINE CARBOXYPEPTIDASE CTSA-4.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05388">
        <property type="entry name" value="Carbpep_Y_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00131">
        <property type="entry name" value="CARBOXYPEPT_SER_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 13" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 13" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0926">Vacuole</keyword>
    <keyword evidence="8" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012836766" description="Carboxypeptidase" evidence="14">
        <location>
            <begin position="16"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="domain" description="Propeptide carboxypeptidase Y" evidence="15">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00025622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00052076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF05388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OAG03800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="543" mass="61193" checksum="599A514EBA1C0BF6" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CAY6</accession>
    <name>A0A177CAY6_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Inactive metallocarboxypeptidase ECM14</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Inactive metallocarboxypeptidase ecm14</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CC84DRAFT_1217805</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Inactive carboxypeptidase that may play a role in cell wall organization and biogenesis.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Vacuole</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the peptidase M14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG04341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034706.1">
        <property type="nucleotide sequence ID" value="XM_018182935.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CAY6"/>
    <dbReference type="FunCoup" id="A0A177CAY6">
        <property type="interactions" value="834"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CAY6"/>
    <dbReference type="GeneID" id="28766421"/>
    <dbReference type="InParanoid" id="A0A177CAY6"/>
    <dbReference type="OrthoDB" id="3626597at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03860">
        <property type="entry name" value="M14_CP_A-B_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000060">
        <property type="entry name" value="Putative metallocarboxypeptidase ecm14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000834">
        <property type="entry name" value="Peptidase_M14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11705:SF147">
        <property type="entry name" value="INACTIVE METALLOCARBOXYPEPTIDASE ECM14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11705">
        <property type="entry name" value="PROTEASE FAMILY M14 CARBOXYPEPTIDASE A,B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00246">
        <property type="entry name" value="Peptidase_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00765">
        <property type="entry name" value="CRBOXYPTASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00631">
        <property type="entry name" value="Zn_pept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52035">
        <property type="entry name" value="PEPTIDASE_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="8 17" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0926">Vacuole</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008057944" description="Inactive metallocarboxypeptidase ECM14" evidence="17">
        <location>
            <begin position="22"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M14" evidence="18">
        <location>
            <begin position="194"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00026187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00026213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS52035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="OAG04341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="555" mass="61927" checksum="0924CEBA88AAF08B" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CAY8</accession>
    <name>A0A177CAY8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1261033</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG04009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034374.1">
        <property type="nucleotide sequence ID" value="XM_018185029.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CAY8"/>
    <dbReference type="STRING" id="1460663.A0A177CAY8"/>
    <dbReference type="GeneID" id="28768515"/>
    <dbReference type="InParanoid" id="A0A177CAY8"/>
    <dbReference type="OrthoDB" id="3789787at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="358"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="13"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG04009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="378" mass="43485" checksum="D206D427402BD8AA" modified="2016-09-07" version="1">MSISNMNSFCQHLLEANRLNQLLLNRIQELELELSQVRLTSRPLYTQDTLNPPNPAPSSTPVTRPAAARLKRTETPQQLFLKNMTDTKVYTVGIEPQDDRGLLHDFFEDIRKWAIHYTINLADEVLSHCSTMKDVVAIIGDKSDIHHLLADREMRQDVVSALIVRDIVFHAIGEGSMFNSKHRNGELCGEIVSSFAMLSHQDYRAKHQLCLRQAALYQEMYGEHNHHEWRTKQANERTKALLNTLSPFLHWGINTDGEHSLSELYVKGYRIGFRLRSHAIKWQVIFPVAGMQLDLKRMVNRTLNLAGDPMTTWTELTKNPERYFVRFAITPTMIKSDFSAGYEVKEVVHSSLVHVGRQNVSSHRKDTQMTSRKNGRKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CBA3</accession>
    <name>A0A177CBA3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1166255</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG04152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034517.1">
        <property type="nucleotide sequence ID" value="XM_018178910.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CBA3"/>
    <dbReference type="STRING" id="1460663.A0A177CBA3"/>
    <dbReference type="GeneID" id="28762396"/>
    <dbReference type="InParanoid" id="A0A177CBA3"/>
    <dbReference type="OrthoDB" id="5206661at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="257"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="430"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="435"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="452"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="468"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="491"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="512"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="580"/>
            <end position="594"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG04152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="600" mass="67241" checksum="22F9F90284D91D2B" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CBM3</accession>
    <name>A0A177CBM3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">cyclic pyranopterin monophosphate synthase</fullName>
            <ecNumber evidence="3">4.6.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CC84DRAFT_1066569</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate = cyclic pyranopterin phosphate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:49580"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:59648"/>
            <dbReference type="ChEBI" id="CHEBI:131766"/>
            <dbReference type="EC" id="4.6.1.17"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.17" evidence="3"/>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG04100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034465.1">
        <property type="nucleotide sequence ID" value="XM_018173636.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CBM3"/>
    <dbReference type="STRING" id="1460663.A0A177CBM3"/>
    <dbReference type="GeneID" id="28757122"/>
    <dbReference type="InParanoid" id="A0A177CBM3"/>
    <dbReference type="OrthoDB" id="429626at2759"/>
    <dbReference type="UniPathway" id="UPA00344"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061799">
        <property type="term" value="F:cyclic pyranopterin monophosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061798">
        <property type="term" value="F:GTP 3',8'-cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01420">
        <property type="entry name" value="MoaC_PE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.640">
        <property type="entry name" value="Molybdopterin cofactor biosynthesis C (MoaC) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023045">
        <property type="entry name" value="MoaC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047594">
        <property type="entry name" value="MoaC_bact/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036522">
        <property type="entry name" value="MoaC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050105">
        <property type="entry name" value="MoCo_biosynth_MoaA/MoaC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002820">
        <property type="entry name" value="Mopterin_CF_biosynth-C_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00581">
        <property type="entry name" value="moaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006870">
        <property type="entry name" value="PRK09364.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22960:SF0">
        <property type="entry name" value="MOLYBDENUM COFACTOR BIOSYNTHESIS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22960">
        <property type="entry name" value="MOLYBDOPTERIN COFACTOR SYNTHESIS PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01967">
        <property type="entry name" value="MoaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55040">
        <property type="entry name" value="Molybdenum cofactor biosynthesis protein C, MoaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Molybdopterin cofactor biosynthesis C (MoaC)" evidence="6">
        <location>
            <begin position="17"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAG04100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="175" mass="18034" checksum="A56CC9C6D79825E8" modified="2016-09-07" version="1" fragment="single">HLQTSLPHLTSSGAAHMVSVASKPSTERTAIATGTVRFSNPTPLSLIHAASNKKGDVLSVSRIAGIMAAKHTPTLIPLCHPIALTHVGVSLHVVLPFSASSSVVGKDKDAKDFGSIVVESKVSCTGQTGVEMEALTSVTGAALSVVDMCKAVDKGISISDVRVVLKEGGRSGTWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CCM1</accession>
    <name>A0A177CCM1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Brix-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1118498</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG05385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035750.1">
        <property type="nucleotide sequence ID" value="XM_018175520.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CCM1"/>
    <dbReference type="FunCoup" id="A0A177CCM1">
        <property type="interactions" value="896"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CCM1"/>
    <dbReference type="GeneID" id="28759006"/>
    <dbReference type="InParanoid" id="A0A177CCM1"/>
    <dbReference type="OrthoDB" id="264354at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042134">
        <property type="term" value="F:rRNA primary transcript binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000460">
        <property type="term" value="P:maturation of 5.8S rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000470">
        <property type="term" value="P:maturation of LSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10480:FF:000005">
        <property type="entry name" value="Similar to RNA processing factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10480">
        <property type="entry name" value="Probable brix-domain ribosomal biogenesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007109">
        <property type="entry name" value="Brix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044281">
        <property type="entry name" value="IMP4/RPF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22734:SF3">
        <property type="entry name" value="RIBOSOME PRODUCTION FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22734">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RIBONUCLEOPROTEIN PROTEIN IMP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04427">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00879">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50833">
        <property type="entry name" value="BRIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Brix" evidence="2">
        <location>
            <begin position="207"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="171"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG05385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="438" mass="49985" checksum="ED4FD62645C9CF0B" modified="2016-09-07" version="1">MVFSKEPPMQGFKPKNKLRRQSAHLAQKKSKEAAKRDERFRRKREEAKNPSLREERQRVNQPVTIEAKRKFDTDVVGDEEDALNWAIDVERLAKKRKLEQEAAERGDNVEGNGEEGLLEKLKKRDAEGNEVEDDEEEDEADSMLDSESECEDDSSDTEAVSSRTKRKSERAASPAMSTTTNATAATNLDISPDFLKQKFPAVFNPAETPKILVTTSINSTLHNEAEILASFFPNADYVRRSAHAHAHKYSVREIAKFASNREYTALAILMEAHHAKVPDGLDIVLLPEGPHFHFSISNWVEGKKLPGHGKDQGFHPELVLNGFRTPLGLLTAHLWRGLFPAQPELQGRTAVTLHNQRDYIFLRRHRYVFREKRATEKQVLDANGKPLKGVEDIRVGMQEIGPRATLKLRRIDRGIQFKSGQEWQWKAHAEKERTRFNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CD21</accession>
    <name>A0A177CD21_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small ribosomal subunit protein uS10m</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">37S ribosomal protein S10, mitochondrial</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Mitochondrial ribosomal small subunit protein 10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CC84DRAFT_725096</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS10 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG05553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035918.1">
        <property type="nucleotide sequence ID" value="XM_018187193.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CD21"/>
    <dbReference type="STRING" id="1460663.A0A177CD21"/>
    <dbReference type="GeneID" id="28770679"/>
    <dbReference type="InParanoid" id="A0A177CD21"/>
    <dbReference type="OrthoDB" id="366214at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.600:FF:000003">
        <property type="entry name" value="30S ribosomal protein S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.600">
        <property type="entry name" value="Ribosomal protein S10 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00508">
        <property type="entry name" value="Ribosomal_uS10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001848">
        <property type="entry name" value="Ribosomal_uS10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027486">
        <property type="entry name" value="Ribosomal_uS10_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036838">
        <property type="entry name" value="Ribosomal_uS10_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11700">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S10 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00338">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01403">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54999">
        <property type="entry name" value="Ribosomal protein S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS10" evidence="8">
        <location>
            <begin position="250"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="80"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="93"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00042916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00078476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAG05553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="437" mass="49770" checksum="05838B323A097756" modified="2016-09-07" version="1">MRSKIYQAMCGRRGDVDFVLARCSPRQRVLPGGGPLRPSANVLLHSAMLHATSTNPSAMAAPRSLRPFLAPAKRIKITPPRSSAQTFLRCKSKRAEDRDDDREWRTKPDENDGADVDIFAEMEKGEMPFEQRLEHMGIDAAEYKALKTSSKAAEEKLNRWTPKSKEDAQRKWKRMVNAPEDNTLLEMFKREGVDVLAEGKARELRLPTDKDPLDPKTQEALDALRTPVNVQAVHLRPLRRAPTHGVPVCDLQLRTYSIRNLLLFADFAVRAAYYMGLCARGPIPLPRITERWTVPRANFIFKKSQENFERITMRRLIQIQDGHPDVVKAWLAFLQKHQYYGVGMKANIWEFESLEAATRAGYNLDADDHSRRREGPMIEKVKEILSTPAYKEALADYTMPNSIELRPGGYKVPKEIMGRKARKAANKANRAEKQLNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CE55</accession>
    <name>A0A177CE55_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UBA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1218455</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG05068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035433.1">
        <property type="nucleotide sequence ID" value="XM_018182999.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CE55"/>
    <dbReference type="STRING" id="1460663.A0A177CE55"/>
    <dbReference type="GeneID" id="28766485"/>
    <dbReference type="InParanoid" id="A0A177CE55"/>
    <dbReference type="OrthoDB" id="5376710at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00627">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBA" evidence="2">
        <location>
            <begin position="693"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="563"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="650"/>
            <end position="678"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG05068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="741" mass="83838" checksum="1952C1FCF009619F" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CEB5</accession>
    <name>A0A177CEB5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1165436</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG05107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035472.1">
        <property type="nucleotide sequence ID" value="XM_018178715.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CEB5"/>
    <dbReference type="STRING" id="1460663.A0A177CEB5"/>
    <dbReference type="GeneID" id="28762201"/>
    <dbReference type="InParanoid" id="A0A177CEB5"/>
    <dbReference type="OrthoDB" id="5238363at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG05107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="261" mass="29963" checksum="BA29D50CE33962B9" modified="2016-09-07" version="1">MKSIFNRFSRFQPTTFKVSYSPEYRTYLQHHAASDWLHPLHILRRRELAERKREALWWHVTSGIDLSRSSVVRSWCRRRLRGAFTEGLKERGFDEFGRLLNVAKLREQKGFKSLSERNADLSLDGSVRLHITPALVTAKYADVRKETGGIIDILVEALRDNLQASHLSNPRPQPRSQPKTLPQSKAPSRPRETASQVLPSNQSQEGQLSQLNLPSHTKAQSPVIRYRSTPSNSHPPKISTKRKTQQPPDNAKPQRHSRDTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CEH2</accession>
    <name>A0A177CEH2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1164413</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG06033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036398.1">
        <property type="nucleotide sequence ID" value="XM_018178482.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CEH2"/>
    <dbReference type="STRING" id="1460663.A0A177CEH2"/>
    <dbReference type="GeneID" id="28761968"/>
    <dbReference type="InParanoid" id="A0A177CEH2"/>
    <dbReference type="OrthoDB" id="419598at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051604">
        <property type="entry name" value="Ergot_Alk_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43162">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43162:SF1">
        <property type="entry name" value="PRESTALK A DIFFERENTIATION PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="1">
        <location>
            <begin position="2"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG06033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="301" mass="33429" checksum="2AE7D044208478AC" modified="2016-09-07" version="1">MRVVVFGASGVQGAHQVPVLAKAGHDVVAVSRNPKHLEVDGKTIETFAADFADKAKISKAIAGSDAIFLNLPSTSFNQSGPILQGAKDIGEAAKEAGIKLIVFNTSMPVPKEAQDIKAQDDRREMKRLLRETGMPVVSIEPVVYIDNLLEGWALPPIRDRNTVVYCHKPDLQVSWICHHDVAQLMVAALQRPELAGRDFAVGGPETVRLEQLAEKLSRAWGRKLEYENQTVEDFCNKIGKTMQGRGLETEKIVSQMFKAYTYYNEAEDEPFNIDMAPVLKELPVKLTPIEEWAKRRSPPGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CEK2</accession>
    <name>A0A177CEK2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_1260449</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG05229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035594.1">
        <property type="nucleotide sequence ID" value="XM_018184987.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CEK2"/>
    <dbReference type="GeneID" id="28768473"/>
    <dbReference type="InParanoid" id="A0A177CEK2"/>
    <dbReference type="OrthoDB" id="1935484at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000247">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000106">
        <property type="entry name" value="MFS transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF104">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="213"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="246"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="325"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="360"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="387"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="416"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="485"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="9"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="22"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAG05229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="544" mass="62546" checksum="B2DCE019F4C20C19" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CF09</accession>
    <name>A0A177CF09_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CC84DRAFT_1186923</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG05781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036146.1">
        <property type="nucleotide sequence ID" value="XM_018180890.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CF09"/>
    <dbReference type="STRING" id="1460663.A0A177CF09"/>
    <dbReference type="GeneID" id="28764376"/>
    <dbReference type="InParanoid" id="A0A177CF09"/>
    <dbReference type="OrthoDB" id="60033at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050956">
        <property type="entry name" value="2C_system_His_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43719:SF31">
        <property type="entry name" value="HISTIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43719">
        <property type="entry name" value="TWO-COMPONENT HISTIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Histidine kinase" evidence="3">
        <location>
            <begin position="462"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="783"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="849"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAG05781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="928" mass="104311" checksum="895F53F249C266D8" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CF95</accession>
    <name>A0A177CF95_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SET domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1164597</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG06293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036658.1">
        <property type="nucleotide sequence ID" value="XM_018178520.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CF95"/>
    <dbReference type="STRING" id="1460663.A0A177CF95"/>
    <dbReference type="GeneID" id="28762006"/>
    <dbReference type="InParanoid" id="A0A177CF95"/>
    <dbReference type="OrthoDB" id="265717at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd20071">
        <property type="entry name" value="SET_SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053185">
        <property type="entry name" value="SET_domain_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47332">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47332:SF2">
        <property type="entry name" value="SET-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SET" evidence="1">
        <location>
            <begin position="3"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG06293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="309" mass="33939" checksum="2A03DF38388FC8D1" modified="2016-09-07" version="1">MTPIYTVSPSPEKGLGCFSTKLIPTGTLILSETPLFNVREPRTNAAVLAAFLNITKSEQENYLTLYAQTATTRDAKVIDIFNSNAWQTGSRTSICPQAARFNHSCVPNASFAWNSRLGKVTVHAVTAIPANTEILLSYERPYQVGSARREKLSAYGFVCSCVACGSGAEASDIRRARMVLLDARIRCQRRQLWRSAIPKAEVELVRILKEEAIVGEALGLAHHDAAVGWRKYGRVDLAVRHAAKELEICIICFGPDSSSVDTTRAFLLELKAQLAKESLLVSEPVLLAEGVSHSTGRRPPRPIWAVYRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CG66</accession>
    <name>A0A177CG66_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Kinase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1092613</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG05740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036105.1">
        <property type="nucleotide sequence ID" value="XM_018174470.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CG66"/>
    <dbReference type="STRING" id="1460663.A0A177CG66"/>
    <dbReference type="GeneID" id="28757956"/>
    <dbReference type="InParanoid" id="A0A177CG66"/>
    <dbReference type="OrthoDB" id="25129at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="27"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG05740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="378" mass="41617" checksum="30966B6245494FFB" modified="2016-09-07" version="1">MASEFDLTTERGLSAYLTSRSVSHTSVSLLTGGTANYVYRVTLPDGSTKIYKHAAPYLHSNTAFAFDPSRMDYEHRVLELQTSSPHLLSSHSPEASVHAVAVHSYDKENKLLCISDGGSRHLKDAYADPTLDMSSIGAALGRWLAALHTSTVATPLSLDPTSQNLKDNNAIAVSIYRHSYRNLSSAFAEYGDSGGNVPRYADFIDLPDKDIEFAQQINDAYGSRLAHENECICHGDFWPGNVLVKPASEEGGKVVLTVVDWEMTRRGTSATDAAQFLAESLLLDRFCGHRGLVPAFLNAYLSARPEIPGKEWFRRLAIHAGVHIAFWPTRVAWTDRRGTHALVELGKSILRAASESKWETLFGLPLFSGMEEIFLPAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2023-09-13" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CGF4</accession>
    <name>A0A177CGF4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_610491</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG06654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037019.1">
        <property type="nucleotide sequence ID" value="XM_018186881.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CGF4"/>
    <dbReference type="GeneID" id="28770367"/>
    <dbReference type="InParanoid" id="A0A177CGF4"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008058248" description="Secreted protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG06654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="130" mass="13824" checksum="1BDB07071A2CE9D9" modified="2016-09-07" version="1">MTVSARSWIISFSMIAMRALAAVLLTFSTISQASLSEHGTPTATAECWTPRKPYAGSVAFPQVPLISLSSGSLGGTLFERQNSETVWKGRIFSVLTFHSGAQCSSTTGAEYSCPGNATCVSVMFNVWECG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CI76</accession>
    <name>A0A177CI76_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Intramembrane protease 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CC84DRAFT_1143174</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase A22B family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG06961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037326.1">
        <property type="nucleotide sequence ID" value="XM_018176398.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CI76"/>
    <dbReference type="FunCoup" id="A0A177CI76">
        <property type="interactions" value="16"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CI76"/>
    <dbReference type="GeneID" id="28759884"/>
    <dbReference type="InParanoid" id="A0A177CI76"/>
    <dbReference type="OrthoDB" id="29661at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098554">
        <property type="term" value="C:cytoplasmic side of endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098553">
        <property type="term" value="C:lumenal side of endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042500">
        <property type="term" value="F:aspartic endopeptidase activity, intramembrane cleaving"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033619">
        <property type="term" value="P:membrane protein proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007369">
        <property type="entry name" value="Peptidase_A22B_SPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006639">
        <property type="entry name" value="Preselin/SPP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12174:SF23">
        <property type="entry name" value="MINOR HISTOCOMPATIBILITY ANTIGEN H13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12174">
        <property type="entry name" value="SIGNAL PEPTIDE PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04258">
        <property type="entry name" value="Peptidase_A22B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00730">
        <property type="entry name" value="PSN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="88"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="118"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="226"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="275"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="336"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="420"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="443"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="50"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="473"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="560"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="66"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="481"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="562"/>
            <end position="593"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAG06961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="614" mass="69149" checksum="22680EDDE2F011B8" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CIQ9</accession>
    <name>A0A177CIQ9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">rhamnogalacturonan endolyase</fullName>
            <ecNumber evidence="4">4.2.2.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CC84DRAFT_1242940</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endotype eliminative cleavage of L-alpha-rhamnopyranosyl-(1-&gt;4)-alpha-D-galactopyranosyluronic acid bonds of rhamnogalacturonan I domains in ramified hairy regions of pectin leaving L-rhamnopyranose at the reducing end and 4-deoxy-4,5-unsaturated D-galactopyranosyluronic acid at the non-reducing end.</text>
            <dbReference type="EC" id="4.2.2.23"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the polysaccharide lyase 4 family.</text>
    </comment>
    <dbReference type="EC" id="4.2.2.23" evidence="4"/>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG07404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037769.1">
        <property type="nucleotide sequence ID" value="XM_018184101.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CIQ9"/>
    <dbReference type="STRING" id="1460663.A0A177CIQ9"/>
    <dbReference type="GeneID" id="28767587"/>
    <dbReference type="InParanoid" id="A0A177CIQ9"/>
    <dbReference type="OrthoDB" id="114708at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102210">
        <property type="term" value="F:rhamnogalacturonan endolyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045490">
        <property type="term" value="P:pectin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10317">
        <property type="entry name" value="RGL4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10316">
        <property type="entry name" value="RGL4_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1120">
        <property type="entry name" value="Carboxypeptidase-like, regulatory domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013784">
        <property type="entry name" value="Carb-bd-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029413">
        <property type="entry name" value="RG-lyase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029411">
        <property type="entry name" value="RG-lyase_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016590">
        <property type="entry name" value="Rhamnogalacturonase_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015364">
        <property type="entry name" value="RhgB_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36574">
        <property type="entry name" value="RHAMNOGALACTURONATE LYASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36574:SF1">
        <property type="entry name" value="RHAMNOGALACTURONATE LYASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14683">
        <property type="entry name" value="CBM-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14686">
        <property type="entry name" value="fn3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09284">
        <property type="entry name" value="RhgB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49452">
        <property type="entry name" value="Starch-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="10" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008058258" description="rhamnogalacturonan endolyase" evidence="12">
        <location>
            <begin position="19"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="domain" description="Rhamnogalacturonase B N-terminal" evidence="13">
        <location>
            <begin position="20"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="Rhamnogalacturonan lyase" evidence="15">
        <location>
            <begin position="282"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="Rhamnogalacturonan lyase" evidence="14">
        <location>
            <begin position="371"/>
            <end position="543"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF09284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF14683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF14686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OAG07404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="544" mass="58842" checksum="9AD3689326C9C7C6" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2023-06-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CJG9</accession>
    <name>A0A177CJG9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_704745</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG07665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038030.1">
        <property type="nucleotide sequence ID" value="XM_018187115.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CJG9"/>
    <dbReference type="GeneID" id="28770601"/>
    <dbReference type="InParanoid" id="A0A177CJG9"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG07665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="152" mass="17229" checksum="6D52F0CC51B84B89" modified="2016-09-07" version="1">MHPSRRRGLSTECQPHSRGRPQLTRSNVVTLNHNDSKGLLGASSSRLWARNALRGVTASMVHSGSVQLHVENSAQWLSRHGTYRASLYITKEVNLLSQEQGKYDSGNRYPCTAVSRWLVASSRVVASKWFITPPRFGAREFRKHLHVDYDQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CK06</accession>
    <name>A0A177CK06_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidase M12A domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1175361</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG07581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037946.1">
        <property type="nucleotide sequence ID" value="XM_018180148.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CK06"/>
    <dbReference type="STRING" id="1460663.A0A177CK06"/>
    <dbReference type="GeneID" id="28763634"/>
    <dbReference type="InParanoid" id="A0A177CK06"/>
    <dbReference type="OrthoDB" id="291007at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001506">
        <property type="entry name" value="Peptidase_M12A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127">
        <property type="entry name" value="DISCOIDIN, CUB, EGF, LAMININ , AND ZINC METALLOPROTEASE DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127:SF850">
        <property type="entry name" value="METALLOENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01400">
        <property type="entry name" value="Astacin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008058324" description="Peptidase M12A domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M12A" evidence="2">
        <location>
            <begin position="200"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG07581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="404" mass="45384" checksum="D857E2E8A619041C" modified="2016-09-07" version="1">MRIRAFLLATQFWCYSVTALSFGNDFNGTIPSILGITNFSYPAASSNIGFGYADGVVNTDYHQPWPLVKMYKSSVHLIRYCYADQASKDALHCSWPAAENLWQDALGGKPSKETGYNLHFVQAWAAGETQFCYAEGTYDPKTAQGTWNWKLHNRQDALVVAYRPVDEKGNKPATSASLGYTPESALFPWQSRQARHYIQISDKDDEVRIAHELGHVLGLLHEHQRSDRDTVIEYRPENIAGYTEALAAAIKDKVPEAEARQKLRDDVPFCQKYNFRGSAYVKNADQPGPIIGDHAQGPLDFDFDSIMIYPSDAQTDTAACRADLAHCPIVRRAGTSSDGKSKFEYIAAKGKPSAKDVEFVRKHYAWREEEVSQRRKRSSREVGEVKVQIKIRRSNSEVQRGMGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CKA6</accession>
    <name>A0A177CKA6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1258391</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG07227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037592.1">
        <property type="nucleotide sequence ID" value="XM_018184827.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CKA6"/>
    <dbReference type="GeneID" id="28768313"/>
    <dbReference type="InParanoid" id="A0A177CKA6"/>
    <dbReference type="OrthoDB" id="10300271at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008058394" evidence="1">
        <location>
            <begin position="19"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG07227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="94" mass="9433" checksum="C6EDDCA1F971B079" modified="2016-09-07" version="1">MKFSIIASIFALASVGMAAPTQDGAVKTLNKRGPCPEAGSGNIDPCCFDGGPDENCKSQSNCYERCGPSGPNDQGGVLGCIAGCASVCPSTPEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CKB4</accession>
    <name>A0A177CKB4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ER membrane protein-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1087884</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG07280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037645.1">
        <property type="nucleotide sequence ID" value="XM_018174222.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CKB4"/>
    <dbReference type="FunCoup" id="A0A177CKB4">
        <property type="interactions" value="79"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CKB4"/>
    <dbReference type="GeneID" id="28757708"/>
    <dbReference type="InParanoid" id="A0A177CKB4"/>
    <dbReference type="OrthoDB" id="5577218at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032541">
        <property type="term" value="C:cortical endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097038">
        <property type="term" value="C:perinuclear endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048309">
        <property type="term" value="P:endoplasmic reticulum inheritance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000921">
        <property type="term" value="P:septin ring assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013635">
        <property type="entry name" value="Ice2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31726">
        <property type="entry name" value="PROTEIN ICE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31726:SF2">
        <property type="entry name" value="PROTEIN ICE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08426">
        <property type="entry name" value="ICE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="204"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="299"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="355"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG07280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="442" mass="48498" checksum="FD758CCDE6458751" modified="2016-09-07" version="1">MWLTRVLSSTCFLGAIIFTIPLAFDIGGRTCGLAFSLSLSAYYFVYSVLRLATPANSRFRWALGQLFAWTQWLMIGTLLIWSLNKFSIDADNSSGWVERTFGGKRSDDTSVYEWIFGAEGLLQSATIGAWDSVLRYSTPVFQILEGFCSLLVIQASGQVTRWVVNGERGDSWMIGLLITSASIISSSVYFLWRITTFPEISNVDAILIGVAITTAIFLCAWGIVSGKGNPVESSLLFAYVTLCIYQIFTDYQPAPGSVAADAPSDPALPPLPPIIMASYTTLLHALGSLPTIMHTAYNLMVGAIMTISLSVIISLAYRVFVFYAAARIIPAIRESGARALSEEPSLDDEDDTTKILGFLTWFSPSIIIAVYTSLLMQHFASGNGDANGSAVQGEWWKSQGGETGGNLWRWINLGITMAMYAIELKMSKEDDDGRLTQHWKTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CKD2</accession>
    <name>A0A177CKD2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1173538</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG07953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038318.1">
        <property type="nucleotide sequence ID" value="XM_018180043.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CKD2"/>
    <dbReference type="GeneID" id="28763529"/>
    <dbReference type="InParanoid" id="A0A177CKD2"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="86"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="223"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG07953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="249" mass="27246" checksum="5C2683182CFBC9E1" modified="2016-09-07" version="1">MSFLAPVVSFREHGVTPRALQVCIASLEVIGCNCTIGPHCDHFNCFAIPVFQHLSLAAASVLGVWANDGCRRASEPASIIIRWYQICYNTLAPVLFLMYSLVMVLQPWNGAKYYRMTHLVEKCCINSAVQSSRLGLGPHCGEATHDPLSLYNFQFEIEMRTETEPTLRIFEAGIPTTERQKVEQGGPQHTRHTAGDGCPSLGVRLDSRLLQVTCVQPLCGQTAAGEESQPGDVRGHAASVEGSRKFSLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CKQ8</accession>
    <name>A0A177CKQ8_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Large ribosomal subunit protein mL50</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CC84DRAFT_522190</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mL50 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG07886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038251.1">
        <property type="nucleotide sequence ID" value="XM_018186614.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CKQ8"/>
    <dbReference type="STRING" id="1460663.A0A177CKQ8"/>
    <dbReference type="GeneID" id="28770100"/>
    <dbReference type="InParanoid" id="A0A177CKQ8"/>
    <dbReference type="OrthoDB" id="6220758at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018305">
        <property type="entry name" value="Ribosomal_m50"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10501">
        <property type="entry name" value="Ribosomal_L50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAG07886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="659" mass="73661" checksum="89ADE741AB94CCA2" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CLJ1</accession>
    <name>A0A177CLJ1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1161886</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG07812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038177.1">
        <property type="nucleotide sequence ID" value="XM_018177851.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CLJ1"/>
    <dbReference type="GeneID" id="28761337"/>
    <dbReference type="InParanoid" id="A0A177CLJ1"/>
    <dbReference type="OrthoDB" id="9876299at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051468">
        <property type="entry name" value="Fungal_SecMetab_SDRs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43544:SF26">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY OXIDOREDUCTASE (JCVI)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43544">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG07812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="249" mass="26549" checksum="549FD21EC3A82845" modified="2016-09-07" version="1">METKTTVLITGSNRGIGLGLVERFLAKPSHVVIAAVRNPGHPTAQALHSLPTGPDTQLIVVKIDASIEKDAHDAVAKLQQKHGVGHLDIVIANAGVAYIYPTVADVKIEDIKAHMQPNVYGVIALYQATRGLLKKAAREPIFMIMGSSAGLLGNHLPIPNAAYAPTKTVLNWYTRRVDAEDNWLNCFSIDPGHVSTDLGNAAAQAVGMGDHAPTTVQESCDGMMIVLAKASKKVYGGKLAVYTGEFHGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CLY5</accession>
    <name>A0A177CLY5_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cyclin-D1-binding protein 1-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_1087329</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG07952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038317.1">
        <property type="nucleotide sequence ID" value="XM_018174198.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CLY5"/>
    <dbReference type="STRING" id="1460663.A0A177CLY5"/>
    <dbReference type="GeneID" id="28757684"/>
    <dbReference type="InParanoid" id="A0A177CLY5"/>
    <dbReference type="OrthoDB" id="4088536at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1410.10">
        <property type="entry name" value="I/LWEQ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026907">
        <property type="entry name" value="GCIP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049317">
        <property type="entry name" value="GCIP-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15492">
        <property type="entry name" value="CYCLIN D1-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15492:SF1">
        <property type="entry name" value="CYCLIN-D1-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13324">
        <property type="entry name" value="GCIP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008058361" description="Cyclin-D1-binding protein 1-like N-terminal domain-containing protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin-D1-binding protein 1-like N-terminal" evidence="3">
        <location>
            <begin position="50"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAG07952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="368" mass="39281" checksum="E5A586F1425240DB" modified="2016-09-07" version="1">MPPKPASLRTLLDLTSTTLALLTHFQSSLSPTATADASIPPPPNPLQALKACTSLLKSHTTTLSLLLLTPPLTPSAIITKIGDVSSGPLTGLVGAAVAEGELGDLMQAEVKVQVRRLLGAWGEVVGCVVRLAERRKKLEDEGGAAQAKKDDGPTEGERQAVLAATGVVWEACDALVKLCDGGIAGLVVRKAEEWRSVLLDAVEELKEWGDDVDDDDAEEGGSDGEFGDEDEMFGAANKLGKEDKELKEVLDKSVKKLKMVGVLYQALIKRRLKTFPSISPATAASAKGHKNPMTTLEELMKLIKSMPEQVDDLASAFYDLDADEAKTMLDKCCGEAKSAATLVKQNWSGNDDEFTAWSTKWVDALNAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CM25</accession>
    <name>A0A177CM25_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CC84DRAFT_1140196</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG07859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038224.1">
        <property type="nucleotide sequence ID" value="XM_018176277.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CM25"/>
    <dbReference type="STRING" id="1460663.A0A177CM25"/>
    <dbReference type="GeneID" id="28759763"/>
    <dbReference type="InParanoid" id="A0A177CM25"/>
    <dbReference type="OrthoDB" id="1924787at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF16">
        <property type="entry name" value="TRANSCRIPTION FACTOR, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G09360)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="6"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAG07859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="516" mass="58686" checksum="6FB0D9DFC0F46CEF" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CMD5</accession>
    <name>A0A177CMD5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">CBF-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_1162591</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CBF/MAK21 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039079.1">
        <property type="nucleotide sequence ID" value="XM_018178034.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CMD5"/>
    <dbReference type="FunCoup" id="A0A177CMD5">
        <property type="interactions" value="611"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CMD5"/>
    <dbReference type="GeneID" id="28761520"/>
    <dbReference type="InParanoid" id="A0A177CMD5"/>
    <dbReference type="OrthoDB" id="10263185at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030692">
        <property type="term" value="C:Noc4p-Nop14p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000480">
        <property type="term" value="P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000472">
        <property type="term" value="P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005612">
        <property type="entry name" value="CCAAT-binding_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027193">
        <property type="entry name" value="Noc4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12455">
        <property type="entry name" value="NUCLEOLAR COMPLEX PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12455:SF0">
        <property type="entry name" value="NUCLEOLAR COMPLEX PROTEIN 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03914">
        <property type="entry name" value="CBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="391"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="CCAAT-binding factor" evidence="7">
        <location>
            <begin position="321"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAG08714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="547" mass="62266" checksum="324E77134DD9EE56" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CMX5</accession>
    <name>A0A177CMX5_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Alanine--tRNA ligase</fullName>
            <ecNumber evidence="15">6.1.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Alanyl-tRNA synthetase</fullName>
            <shortName evidence="15">AlaRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">ALA1</name>
        <name evidence="17" type="ORF">CC84DRAFT_1086282</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14 15">Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 15">
            <text>tRNA(Ala) + L-alanine + ATP = L-alanyl-tRNA(Ala) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:12540"/>
            <dbReference type="Rhea" id="RHEA-COMP:9657"/>
            <dbReference type="Rhea" id="RHEA-COMP:9923"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78497"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="15">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="15">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="15">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="15">Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family. Alax-L subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.7" evidence="15"/>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039240.1">
        <property type="nucleotide sequence ID" value="XM_018174154.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CMX5"/>
    <dbReference type="FunCoup" id="A0A177CMX5">
        <property type="interactions" value="991"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CMX5"/>
    <dbReference type="GeneID" id="28757640"/>
    <dbReference type="InParanoid" id="A0A177CMX5"/>
    <dbReference type="OrthoDB" id="2423964at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004813">
        <property type="term" value="F:alanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070143">
        <property type="term" value="P:mitochondrial alanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00673">
        <property type="entry name" value="AlaRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.130:FF:000004">
        <property type="entry name" value="Alanine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.310.40:FF:000003">
        <property type="entry name" value="Alanine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000011">
        <property type="entry name" value="Alanine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.980.10:FF:000004">
        <property type="entry name" value="Alanine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.310.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.980.10">
        <property type="entry name" value="Threonyl-trna Synthetase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00036_B">
        <property type="entry name" value="Ala_tRNA_synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002318">
        <property type="entry name" value="Ala-tRNA-lgiase_IIc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018162">
        <property type="entry name" value="Ala-tRNA-ligase_IIc_anticod-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018165">
        <property type="entry name" value="Ala-tRNA-synth_IIc_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018164">
        <property type="entry name" value="Ala-tRNA-synth_IIc_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050058">
        <property type="entry name" value="Ala-tRNA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059090">
        <property type="entry name" value="ALA1_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023033">
        <property type="entry name" value="Ala_tRNA_ligase_euk/bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012947">
        <property type="entry name" value="tRNA_SAD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00344">
        <property type="entry name" value="alaS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11777:SF9">
        <property type="entry name" value="ALANINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11777">
        <property type="entry name" value="ALANYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26023">
        <property type="entry name" value="ALA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01411">
        <property type="entry name" value="tRNA-synt_2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07973">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00980">
        <property type="entry name" value="TRNASYNTHALA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00863">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101353">
        <property type="entry name" value="Putative anticodon-binding domain of alanyl-tRNA synthetase (AlaRS)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="ThrRS/AlaRS common domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50860">
        <property type="entry name" value="AA_TRNA_LIGASE_II_ALA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 15 17" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="8 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 15" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 15" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 15" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10 15" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 15" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 15" id="KW-0820">tRNA-binding</keyword>
    <keyword evidence="7 15" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alanyl-transfer RNA synthetases family profile" evidence="16">
        <location>
            <begin position="10"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="606"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="610"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="725"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="729"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00055137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="OAG08875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="965" mass="108025" checksum="E3FE75A855188800" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2023-06-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CN12</accession>
    <name>A0A177CN12_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_562204</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038554.1">
        <property type="nucleotide sequence ID" value="XM_018186694.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CN12"/>
    <dbReference type="GeneID" id="28770180"/>
    <dbReference type="InParanoid" id="A0A177CN12"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG08189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="173" mass="19800" checksum="3ECE8C88E5E04522" modified="2016-09-07" version="1">MTAASPLHRFFVPHASSPTAAERCVPALCVMDAQSILRRASHWLVRLKTLHTDENSFTLHIAVRHKVRTTCARYGTRSWHATAPTRSNQWRPCHRTSASVLEDERYRQGLPYLPSIRALVTQKLIGFLLMCRPRSTFCKLSASCLHIPHVRLQAQLCKPSTYRVCHLLRMCPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CNQ3</accession>
    <name>A0A177CNQ3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">UbiA prenyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CC84DRAFT_1141313</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038885.1">
        <property type="nucleotide sequence ID" value="XM_018176321.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CNQ3"/>
    <dbReference type="STRING" id="1460663.A0A177CNQ3"/>
    <dbReference type="GeneID" id="28759807"/>
    <dbReference type="InParanoid" id="A0A177CNQ3"/>
    <dbReference type="OrthoDB" id="434972at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016765">
        <property type="term" value="F:transferase activity, transferring alkyl or aryl (other than methyl) groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13965">
        <property type="entry name" value="PT_UbiA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050475">
        <property type="entry name" value="Prenyltransferase_related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42723">
        <property type="entry name" value="CHLOROPHYLL SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42723:SF1">
        <property type="entry name" value="CHLOROPHYLL SYNTHASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="42"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="80"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="138"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="213"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="280"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="310"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAG08520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="399" mass="43800" checksum="B6078D0C75B4AD84" modified="2016-09-07" version="1">MITIPDPLLATVRLLLPLPQLPRISTNSPQAKHLRTVPHHIYTLYLFTAADFPTFAVPTTLFALFASLSGPHLTTNPQPALLPTLTRVPLALAVTWANLLLFNISNQRSPTAVEEDRVNKPARPLPAGRLSCNSARRLLLYLAPAVMLLSWAMGVWEECLLQLAFTWVYNDLGGCDEHWLLRNALIALGYGFYSSAALRVMAGPEHTVTPQGLRWIGVVTAIMFATQHICDIKDAAGDALRGRQSAPIVLGDTVVRWSVAVPILLSSNFCAWYFASGLPAYVATLGLGLLVAFRILAYRDLKSDKKTWKLWALWTVGLFALPLVTNPAVFERTWVDLRVALWEVKCLLCEGERCEMLDLAAVSGIAMVFEGRRMYAQGLGAAGNGSVPEIVVESVVRST</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CP73</accession>
    <name>A0A177CP73_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA mismatch repair protein S5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CC84DRAFT_1257494</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA mismatch repair MutL/HexB family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039055.1">
        <property type="nucleotide sequence ID" value="XM_018184738.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CP73"/>
    <dbReference type="STRING" id="1460663.A0A177CP73"/>
    <dbReference type="GeneID" id="28768224"/>
    <dbReference type="InParanoid" id="A0A177CP73"/>
    <dbReference type="OrthoDB" id="10263226at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032389">
        <property type="term" value="C:MutLalpha complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061982">
        <property type="term" value="P:meiosis I cell cycle process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16926">
        <property type="entry name" value="HATPase_MutL-MLH-PMS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03485">
        <property type="entry name" value="MutL_Trans_hPMS_1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000017">
        <property type="entry name" value="PMS1 homolog 1, mismatch repair system component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014762">
        <property type="entry name" value="DNA_mismatch_repair_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013507">
        <property type="entry name" value="DNA_mismatch_S5_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002099">
        <property type="entry name" value="MutL/Mlh/PMS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038973">
        <property type="entry name" value="MutL/Mlh/Pms-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00585">
        <property type="entry name" value="mutl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073:SF41">
        <property type="entry name" value="MISMATCH REPAIR PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G05820)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01119">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13589">
        <property type="entry name" value="HATPase_c_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01340">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00058">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair protein S5" evidence="4">
        <location>
            <begin position="237"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="465"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="490"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="583"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="677"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="831"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1013"/>
            <end position="1034"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="492"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="517"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="595"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="729"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="1019"/>
            <end position="1034"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAG08690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="1034" mass="113930" checksum="9DA8EA2A3BCE9BB6" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CP92</accession>
    <name>A0A177CP92_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Serine/threonine-protein kinase SSN3</fullName>
            <ecNumber evidence="6">2.7.11.22</ecNumber>
            <ecNumber evidence="5">2.7.11.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="21">Cyclin-dependent kinase 8</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="20">Serine/threonine-protein kinase ssn3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="27" type="ORF">CC84DRAFT_434133</name>
    </gene>
    <organism evidence="27 28">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="27 28" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="27 28">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10216"/>
            <dbReference type="Rhea" id="RHEA-COMP:11321"/>
            <dbReference type="Rhea" id="RHEA-COMP:11322"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43176"/>
            <dbReference type="ChEBI" id="CHEBI:68546"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the SRB8-11 complex, a regulatory module of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="6"/>
    <dbReference type="EC" id="2.7.11.23" evidence="5"/>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG09334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039699.1">
        <property type="nucleotide sequence ID" value="XM_018186248.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CP92"/>
    <dbReference type="FunCoup" id="A0A177CP92">
        <property type="interactions" value="1041"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CP92"/>
    <dbReference type="GeneID" id="28769734"/>
    <dbReference type="InParanoid" id="A0A177CP92"/>
    <dbReference type="OrthoDB" id="6284126at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990508">
        <property type="term" value="C:CKM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008353">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060258">
        <property type="term" value="P:negative regulation of filamentous growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070481">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, non-stop decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031648">
        <property type="term" value="P:protein destabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd07842">
        <property type="entry name" value="STKc_CDK8_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000408">
        <property type="entry name" value="Serine/threonine-protein kinase SSN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000426">
        <property type="entry name" value="Serine/threonine-protein kinase ssn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF495">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0010">Activator</keyword>
    <keyword evidence="13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12 27" id="KW-0418">Kinase</keyword>
    <keyword evidence="14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-0539">Nucleus</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0678">Repressor</keyword>
    <keyword evidence="8" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="17" id="KW-0804">Transcription</keyword>
    <keyword evidence="15" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="26">
        <location>
            <begin position="15"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="368"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00039418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00040708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00041823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00049280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="EMBL" id="OAG09334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="406" mass="45897" checksum="42B55AA3908CB232" modified="2016-09-07" version="1">MFTGYNTKKRVNERYKIIGFISSGTYGRVYKAESRNANPPNSKLFAIKKFKPDKEGELQYSGISQSAIREMALCTELAHPNVVHTVEIILEEKCIFIVFEYAEHDLLQIIHHHNTGGQGGRQAIPARTIKSILWQLLQGLVYLHRNWVMHRDLKPANIMVTSAGKVKIGDLGLARLFYKPLQSLFSGDKVVVTIWYRAPELLLGSRHYTPAVDLWAVGCIFAELLSLRPIFKGEEAKMDGKKTVPFQRNQMQKIVEIVGMPSKERWPLLTSMPEFPQLSSLAAGNARFHRPQGLENWYQGCLKNNLYPPGSGPDTPGPEGFDLLQQLLEYDPQKRLTAENALQHPYFTSHGNPSENCFEESKIKYPVRRVSQEDNDIRTGSLPGTKRSGLPDDSLIGRPAKRLKEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CPR9</accession>
    <name>A0A177CPR9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative BAR adaptor protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CC84DRAFT_1160426</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG09221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039586.1">
        <property type="nucleotide sequence ID" value="XM_018177499.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CPR9"/>
    <dbReference type="FunCoup" id="A0A177CPR9">
        <property type="interactions" value="372"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CPR9"/>
    <dbReference type="GeneID" id="28760985"/>
    <dbReference type="InParanoid" id="A0A177CPR9"/>
    <dbReference type="OrthoDB" id="446293at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051285">
        <property type="term" value="C:cell cortex of cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031097">
        <property type="term" value="C:medial cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990528">
        <property type="term" value="C:Rvs161p-Rvs167p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051666">
        <property type="term" value="P:actin cortical patch localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903475">
        <property type="term" value="P:mitotic actomyosin contractile ring assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097320">
        <property type="term" value="P:plasma membrane tubulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000014">
        <property type="entry name" value="Protein hob3, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004148">
        <property type="entry name" value="BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046982">
        <property type="entry name" value="BIN3/RVS161-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47174">
        <property type="entry name" value="BRIDGING INTEGRATOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47174:SF3">
        <property type="entry name" value="BRIDGING INTEGRATOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03114">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00721">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51021">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BAR" evidence="4">
        <location>
            <begin position="1"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAG09221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="220" mass="24905" checksum="C5A225A7338A5EF5" modified="2016-09-07" version="1">METAANKLQKEAKGYLDSLRAMTASQMRIAETIDAFYGDAGAKDGVSRSYKQAVTDLDAETIKALDGPYRTTVLDPIQRFCSYFPDINACITKRDHKALDYDRTRAQVKKLTDKPDKDVTKLPRAEKDEQMAKASYDQLNEMLTTELPQLIDLRVPYLDPSFEALVKIQLRFCAEAYSRMAQVQQYLDADTRDQYAQGELDAKVEEVLQEIRDLSIAGTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CQ16</accession>
    <name>A0A177CQ16_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_600755</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG09032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039397.1">
        <property type="nucleotide sequence ID" value="XM_018186840.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CQ16"/>
    <dbReference type="GeneID" id="28770326"/>
    <dbReference type="InParanoid" id="A0A177CQ16"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG09032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="161" mass="17872" checksum="5C5F74B154CC442B" modified="2016-09-07" version="1">MQMRPTPPQRHRVPPPLTHPLCRLPARALLRPLLRPLACRAPPARRRRPPSCTPAAPARRTRWIVTSATVPQAAQRSTRARKQTAHQSVPCKPARPHAQGRRRAACPVWAAPPLWPLSPVHTAPSTATCPMPPLRLPRPALRFPPCRRAPSCARMTLTAYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CR38</accession>
    <name>A0A177CR38_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Syntaxin-binding protein-like protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1138085</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the STXBP/unc-18/SEC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG09983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040348.1">
        <property type="nucleotide sequence ID" value="XM_018176179.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CR38"/>
    <dbReference type="FunCoup" id="A0A177CR38">
        <property type="interactions" value="790"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CR38"/>
    <dbReference type="GeneID" id="28759665"/>
    <dbReference type="InParanoid" id="A0A177CR38"/>
    <dbReference type="OrthoDB" id="2228at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005628">
        <property type="term" value="C:prospore membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.830.10">
        <property type="entry name" value="Syntaxin Binding Protein 1, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043154">
        <property type="entry name" value="Sec-1-like_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043127">
        <property type="entry name" value="Sec-1-like_dom3a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001619">
        <property type="entry name" value="Sec1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027482">
        <property type="entry name" value="Sec1-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036045">
        <property type="entry name" value="Sec1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11679">
        <property type="entry name" value="VESICLE PROTEIN SORTING-ASSOCIATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00995">
        <property type="entry name" value="Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005715">
        <property type="entry name" value="VPS45_Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56815">
        <property type="entry name" value="Sec1/munc18-like (SM) proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="615"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="656"/>
            <end position="673"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG09983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="717" mass="80870" checksum="A3047154266D9FEA" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CR82</accession>
    <name>A0A177CR82_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="20 21">NADPH--cytochrome P450 reductase</fullName>
            <shortName evidence="20">CPR</shortName>
            <shortName evidence="20">P450R</shortName>
            <ecNumber evidence="20 21">1.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">cprA</name>
        <name evidence="24" type="ORF">CC84DRAFT_460240</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24 25">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="20">This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5. Involved in ergosterol biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19 20 21">
            <text>2 oxidized [cytochrome P450] + NADPH = 2 reduced [cytochrome P450] + NADP(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24040"/>
            <dbReference type="Rhea" id="RHEA-COMP:14627"/>
            <dbReference type="Rhea" id="RHEA-COMP:14628"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:55376"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="EC" id="1.6.2.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="20">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="20">Binds 1 FAD per monomer.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="20">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
        <text evidence="20">Binds 1 FMN per monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="20">Endoplasmic reticulum membrane</location>
            <topology evidence="20">Single-pass membrane protein</topology>
            <orientation evidence="20">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="20">Mitochondrion outer membrane</location>
            <topology evidence="20">Single-pass membrane protein</topology>
            <orientation evidence="20">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="20">Cell membrane</location>
            <topology evidence="20">Single-pass membrane protein</topology>
            <orientation evidence="20">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="20">Belongs to the NADPH--cytochrome P450 reductase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="20 21">In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="20">In the N-terminal section; belongs to the flavodoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.6.2.4" evidence="20 21"/>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040389.1">
        <property type="nucleotide sequence ID" value="XM_018186369.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CR82"/>
    <dbReference type="FunCoup" id="A0A177CR82">
        <property type="interactions" value="818"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CR82"/>
    <dbReference type="GeneID" id="28769855"/>
    <dbReference type="InParanoid" id="A0A177CR82"/>
    <dbReference type="OrthoDB" id="1856718at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003958">
        <property type="term" value="F:NADPH-hemoprotein reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06204">
        <property type="entry name" value="CYPOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.990.10:FF:000009">
        <property type="entry name" value="NADPH--cytochrome P450 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000100">
        <property type="entry name" value="NADPH--cytochrome P450 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000111">
        <property type="entry name" value="NADPH--cytochrome P450 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.360:FF:000024">
        <property type="entry name" value="NADPH--cytochrome P450 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000018">
        <property type="entry name" value="NADPH--cytochrome P450 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.990.10">
        <property type="entry name" value="NADPH-cytochrome p450 Reductase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03212">
        <property type="entry name" value="NCPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003097">
        <property type="entry name" value="CysJ-like_FAD-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001094">
        <property type="entry name" value="Flavdoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023173">
        <property type="entry name" value="NADPH_Cyt_P450_Rdtase_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023208">
        <property type="entry name" value="P450R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384:SF17">
        <property type="entry name" value="NADPH--CYTOCHROME P450 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384">
        <property type="entry name" value="NITRIC OXIDE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00667">
        <property type="entry name" value="FAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00258">
        <property type="entry name" value="Flavodoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000208">
        <property type="entry name" value="P450R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00369">
        <property type="entry name" value="FLAVODOXIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 20" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 20 21" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 20" id="KW-0274">FAD</keyword>
    <keyword evidence="3 20" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4 20" id="KW-0288">FMN</keyword>
    <keyword evidence="2 20" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="14 20" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="16 20 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="15 20" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 20" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="9 20 21" id="KW-0521">NADP</keyword>
    <keyword evidence="12 20 21" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 20" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="18 20" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="13 20" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="17 20" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="22">
        <location>
            <begin position="66"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="23">
        <location>
            <begin position="277"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <begin position="72"/>
            <end position="77"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <begin position="123"/>
            <end position="126"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <begin position="169"/>
            <end position="178"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="296"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <begin position="452"/>
            <end position="455"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <begin position="470"/>
            <end position="472"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <begin position="487"/>
            <end position="490"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="553"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <begin position="615"/>
            <end position="616"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <begin position="621"/>
            <end position="625"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="657"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="695"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00049342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PIRNR" id="PIRNR000208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="OAG10024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="696" mass="77366" checksum="85D2113EF970C4D6" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CRH5</accession>
    <name>A0A177CRH5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1161126</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040490.1">
        <property type="nucleotide sequence ID" value="XM_018177658.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CRH5"/>
    <dbReference type="GeneID" id="28761144"/>
    <dbReference type="InParanoid" id="A0A177CRH5"/>
    <dbReference type="OrthoDB" id="1022638at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG10125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="63" mass="6739" checksum="EF5F710342111A31" modified="2016-09-07" version="1">MPSNLTGGIVSTAVGSDDVPFDAHIELLCAHSPHFDEALDDRFEVVGALRLSLEEDGCLRVCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CRU2</accession>
    <name>A0A177CRU2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Asparagine synthetase domain-containing protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CC84DRAFT_1255918</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040371.1">
        <property type="nucleotide sequence ID" value="XM_018184583.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CRU2"/>
    <dbReference type="FunCoup" id="A0A177CRU2">
        <property type="interactions" value="741"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CRU2"/>
    <dbReference type="GeneID" id="28768069"/>
    <dbReference type="InParanoid" id="A0A177CRU2"/>
    <dbReference type="OrthoDB" id="10252281at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004066">
        <property type="term" value="F:asparagine synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006529">
        <property type="term" value="P:asparagine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01991">
        <property type="entry name" value="Asn_synthase_B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03766">
        <property type="entry name" value="Gn_AT_II_novel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001962">
        <property type="entry name" value="Asn_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051857">
        <property type="entry name" value="Asn_synthetase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45937">
        <property type="entry name" value="ASPARAGINE SYNTHETASE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45937:SF1">
        <property type="entry name" value="ASPARAGINE SYNTHETASE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00733">
        <property type="entry name" value="Asn_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0061">Asparagine biosynthesis</keyword>
    <keyword evidence="3" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="4">
        <location>
            <begin position="2"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAG10006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="569" mass="62569" checksum="9F07799891E168B1" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CS99</accession>
    <name>A0A177CS99_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1213155</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG09760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040125.1">
        <property type="nucleotide sequence ID" value="XM_018182508.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CS99"/>
    <dbReference type="STRING" id="1460663.A0A177CS99"/>
    <dbReference type="GeneID" id="28765994"/>
    <dbReference type="InParanoid" id="A0A177CS99"/>
    <dbReference type="OrthoDB" id="2906425at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="62"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG09760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="151" mass="16488" checksum="8D385454112247E1" modified="2016-09-07" version="1">MRLRTGGVERSVLRQDVVSHHFCVAHGTEHDCHPYGMFISRAEFNEGLVQALPSARPPGEVSAQDEVLAARVQVLADEGKLFSHGHLHLGNICVEGDANVTGLIDWGGAGLSIHQCDYLEEAALVQAILGRCVEEGVLPGRERRLWFVARV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CT23</accession>
    <name>A0A177CT23_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Amino acid transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CC84DRAFT_1160955</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG09917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040282.1">
        <property type="nucleotide sequence ID" value="XM_018177623.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CT23"/>
    <dbReference type="STRING" id="1460663.A0A177CT23"/>
    <dbReference type="GeneID" id="28761109"/>
    <dbReference type="InParanoid" id="A0A177CT23"/>
    <dbReference type="OrthoDB" id="10062876at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000042">
        <property type="entry name" value="Similar to amino acid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050598">
        <property type="entry name" value="AminoAcid_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785:SF402">
        <property type="entry name" value="AMINO ACID TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="68"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="112"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="158"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="186"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="245"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="285"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="328"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="409"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="434"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="464"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="490"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAG09917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="517" mass="55476" checksum="15D4AC27ACCFFC71" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CTD4</accession>
    <name>A0A177CTD4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Fungal STAND N-terminal Goodbye domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1070139</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040537.1">
        <property type="nucleotide sequence ID" value="XM_018173664.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CTD4"/>
    <dbReference type="GeneID" id="28757150"/>
    <dbReference type="InParanoid" id="A0A177CTD4"/>
    <dbReference type="OrthoDB" id="448455at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031350">
        <property type="entry name" value="Goodbye_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17109">
        <property type="entry name" value="Goodbye"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fungal STAND N-terminal Goodbye" evidence="1">
        <location>
            <begin position="3"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG10172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="70" mass="7619" checksum="C4727FA86F734624" modified="2016-09-07" version="1" fragment="single">FNSKNKIIYAKLDTIFTTIECLGNCIASAVSANSPHIGACFGAVAVRIKSALDDSAHYYRIMEMFEVMGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CVT9</accession>
    <name>A0A177CVT9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 9">cAMP-dependent protein kinase regulatory subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CC84DRAFT_1159153</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="8 9">Tetramer, composed of 2 regulatory (R) and 2 catalytic (C) subunits. In the presence of cAMP it dissociates into 2 active monomeric C subunits and an R dimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the cAMP-dependent kinase regulatory chain family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG11684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042049.1">
        <property type="nucleotide sequence ID" value="XM_018177155.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CVT9"/>
    <dbReference type="FunCoup" id="A0A177CVT9">
        <property type="interactions" value="414"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CVT9"/>
    <dbReference type="GeneID" id="28760641"/>
    <dbReference type="InParanoid" id="A0A177CVT9"/>
    <dbReference type="OrthoDB" id="417078at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005952">
        <property type="term" value="C:cAMP-dependent protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030552">
        <property type="term" value="F:cAMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004862">
        <property type="term" value="F:cAMP-dependent protein kinase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034236">
        <property type="term" value="F:protein kinase A catalytic subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd12098">
        <property type="entry name" value="DD_R_ScPKA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000039">
        <property type="entry name" value="cAMP-dependent protein kinase regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000118">
        <property type="entry name" value="cAMP-dependent protein kinase regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.890.10">
        <property type="entry name" value="cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050503">
        <property type="entry name" value="cAMP-dep_PK_reg_su-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012198">
        <property type="entry name" value="cAMP_dep_PK_reg_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003117">
        <property type="entry name" value="cAMP_dep_PK_reg_su_I/II_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018488">
        <property type="entry name" value="cNMP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11635">
        <property type="entry name" value="CAMP-DEPENDENT PROTEIN KINASE REGULATORY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11635:SF152">
        <property type="entry name" value="CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02197">
        <property type="entry name" value="RIIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000548">
        <property type="entry name" value="PK_regulatory"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00103">
        <property type="entry name" value="CAMPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00394">
        <property type="entry name" value="RIIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47391">
        <property type="entry name" value="Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00888">
        <property type="entry name" value="CNMP_BINDING_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00889">
        <property type="entry name" value="CNMP_BINDING_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9 10" id="KW-0114">cAMP</keyword>
    <keyword evidence="4 9 10" id="KW-0116">cAMP-binding</keyword>
    <keyword evidence="13" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="12">
        <location>
            <begin position="199"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="12">
        <location>
            <begin position="330"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="129"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="437"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="149"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="437"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="277"/>
        </location>
        <ligand>
            <name>3',5'-cyclic AMP</name>
            <dbReference type="ChEBI" id="CHEBI:58165"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="286"/>
        </location>
        <ligand>
            <name>3',5'-cyclic AMP</name>
            <dbReference type="ChEBI" id="CHEBI:58165"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="397"/>
        </location>
        <ligand>
            <name>3',5'-cyclic AMP</name>
            <dbReference type="ChEBI" id="CHEBI:58165"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="406"/>
        </location>
        <ligand>
            <name>3',5'-cyclic AMP</name>
            <dbReference type="ChEBI" id="CHEBI:58165"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR000548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000548-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OAG11684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="458" mass="50019" checksum="73F6F68E30BB8DB0" modified="2016-09-07" version="1">MSLPPDYSNEISSLNREILKHQPHDVLQFCANFFLRRLESQRAEFLLSQQHSSPQGRGMAESTFPGGNPFGTSPSHTGTYMQRLDEEDENDQVASPTAASFFPNAAMDKAQSNPASEDTFGNFAGFGGFGDAVKSRPQPSGAPEPQPFPNNYNLNRRTSVSAESLNPASSDHSDWTPPRHPKSAEQQARLREAVAGNFLFSHLDDEQSAQVLGALQEKPIPTKGIKVIQQGDVGDYFYVVEKGSFDIYVNQSGKLEAGPDGQGSKVGSVGPGGSFGELALMYNAPRAATVVSAEASNLWALDRVTFRRILMDSAFQRRRMYEGFLEEVPLLASLTPYERSKIADALETKKFPPGTHIIKEGDVGESFYILESGAAEVYKRGNEQPVHRYEKGDYFGELALLNDAPRAASVVSTTEVKVATLGKNGFQRLLGPVEGIMRRNDPSKVQDADGVDPFTKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CW32</accession>
    <name>A0A177CW32_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cell death in tomato 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1159193</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG11733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042098.1">
        <property type="nucleotide sequence ID" value="XM_018177166.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CW32"/>
    <dbReference type="GeneID" id="28760652"/>
    <dbReference type="InParanoid" id="A0A177CW32"/>
    <dbReference type="OrthoDB" id="5226619at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008058654" description="Cell death in tomato 1" evidence="1">
        <location>
            <begin position="18"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG11733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="191" mass="20675" checksum="7B5084F3140A5CC9" modified="2016-09-07" version="1">MYFKSFVALIAASAVSAAPAIKLARDDVQPWQITRLYTHTPSGRPGNDPHSTLNITITDPNTIPVGQSPTGQAVFPPTSANCSLQYLTNEDVPWGVEQSCTTDDNTKTYSTWSFTINKPAEGAAYASENFDLSFKLVDYVHLPGQEVTKTFTGGDHFEVGDNMSGQCGGSGVCNWNLNDTPYDIQQTEAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CW94</accession>
    <name>A0A177CW94_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_519068</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG11087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041452.1">
        <property type="nucleotide sequence ID" value="XM_018186593.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CW94"/>
    <dbReference type="GeneID" id="28770079"/>
    <dbReference type="InParanoid" id="A0A177CW94"/>
    <dbReference type="OrthoDB" id="10501184at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG11087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="97" mass="10539" checksum="6A1E54E21C0814BC" modified="2016-09-07" version="1">MGAIGTQTHLPQPCCTCGLVQLCFSVTICGYCMCSTKSERLIAHSIMRVYQYGVPSQAPNPSLCSGKHWQICPVARHPKNVTIVAESTITPDKQTTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CXF7</accession>
    <name>A0A177CXF7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1079946</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG11881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042246.1">
        <property type="nucleotide sequence ID" value="XM_018173871.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CXF7"/>
    <dbReference type="STRING" id="1460663.A0A177CXF7"/>
    <dbReference type="GeneID" id="28757357"/>
    <dbReference type="InParanoid" id="A0A177CXF7"/>
    <dbReference type="OrthoDB" id="3545916at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG11881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="368" mass="41425" checksum="604C98945F3A8900" modified="2016-09-07" version="1">MNDAATSTSNRSLVEALDAKVLSLQQKLLCNVDKIDAVPDAMFATEFRQLAKAIKALSRQIQLKDPESLIRIDAVTQSLLVGRVKREDLNSAVCIRPIIEAFVWSILYSRLFCNPYKDCHQLSSTIYALANKILSNHQHRWPSPTTSSEKWRVISMEQLVQRVGEEAIATGKIQGKCLQLEANIRRVRSKVKDIIEGYLIRVSPGTNFSRVDAIVDKAFSLALHIFLQRCRIQVVYPDIGDTYDKEQPHLDSIAESIEVEKGRVALIASPGLAKWVDGEGKHLDQRLDVVPAMVLAKPVAKEDDEKQVLMERLTSSKDEALVRIKTSTRKFIHPQVVIPSKPKSEDLFMKIEDTEMADGVQWAWPDAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CXM7</accession>
    <name>A0A177CXM7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glutamate pyruvate transaminase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Glutamic--alanine transaminase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Glutamic--pyruvic transaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CC84DRAFT_41608</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. Alanine aminotransferase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG11652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042017.1">
        <property type="nucleotide sequence ID" value="XM_018186131.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CXM7"/>
    <dbReference type="FunCoup" id="A0A177CXM7">
        <property type="interactions" value="479"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CXM7"/>
    <dbReference type="GeneID" id="28769617"/>
    <dbReference type="InParanoid" id="A0A177CXM7"/>
    <dbReference type="OrthoDB" id="1732682at2759"/>
    <dbReference type="UniPathway" id="UPA00528">
        <property type="reaction ID" value="UER00586"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042853">
        <property type="term" value="P:L-alanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.1970:FF:000001">
        <property type="entry name" value="Alanine aminotransferase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000012">
        <property type="entry name" value="alanine aminotransferase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000010">
        <property type="entry name" value="Alanine aminotransferase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045088">
        <property type="entry name" value="ALAT1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11751">
        <property type="entry name" value="ALANINE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11751:SF29">
        <property type="entry name" value="ALANINE TRANSAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="10">
        <location>
            <begin position="110"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00077894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00078532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00080525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OAG11652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="487" mass="54025" checksum="2D25695BD0C94471" modified="2016-09-07" version="1">MSSSEPRRALSLANINPHVKEAQYAVRGELAVRSEEYRAKLAKGEGKDLPFDTVIAANIGNPQQLDQKPITFFRQVASLLENPLLLEHEETFVKSLGYKPDVFERARWLLKEIKSVGAYSQSQGAPGIRESVAKYIERRDGYPASFSDIYLSNGASSGVNTLMHVICASPNTGVMVPIPQYPLYTATLSVLNAKCVPYYLEESQAWGTSLEAIRTSYDKAIAEGTDVKAIAIINPGNPTGASLPAEDIKSVLEFAAEKSLVVIADEVYQTNVFIGEFISFKKALRDLQKEAPGKFDHIELASLHSISKGMVGECGHRGGYLELVGFDPEVAQQIYKFISIQLCPPVIGQCIVEVMVNPPKEGEPSYELYKKEYDGIFNGLKERAYALYEAFKQMEGVECDKPQGSMYLFPTIKLPQKAIEQAKKENRTPDEFYCFRMLDATGICVVAGSGFGQKEGTLHFRTTFLAPGTDWTGRIVKFHQDFMAEFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CXQ8</accession>
    <name>A0A177CXQ8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1159150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG11682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042047.1">
        <property type="nucleotide sequence ID" value="XM_018177154.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CXQ8"/>
    <dbReference type="GeneID" id="28760640"/>
    <dbReference type="InParanoid" id="A0A177CXQ8"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG11682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="75" mass="8396" checksum="735601AB87BFE6DA" modified="2016-09-07" version="1">MERMVAVRSSFQAGIHNVDTYRRQKLLFSISISIILIIAVIAAARYPELIFDCAFLCVYCAGLYTDMVMGYAALP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CXX2</accession>
    <name>A0A177CXX2_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CC84DRAFT_47842</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG11742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042107.1">
        <property type="nucleotide sequence ID" value="XM_018186426.1"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CXX2"/>
    <dbReference type="GeneID" id="28769912"/>
    <dbReference type="InParanoid" id="A0A177CXX2"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18579">
        <property type="entry name" value="ABC_6TM_ABCC_D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18580">
        <property type="entry name" value="ABC_6TM_ABCC_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000055">
        <property type="entry name" value="ABC multidrug transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000066">
        <property type="entry name" value="ABC multidrug transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000838">
        <property type="entry name" value="ABC multidrug transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001854">
        <property type="entry name" value="ABC multidrug transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044746">
        <property type="entry name" value="ABCC_6TM_D1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044726">
        <property type="entry name" value="ABCC_6TM_D2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056227">
        <property type="entry name" value="TMD0_ABC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF269">
        <property type="entry name" value="ABC MULTIDRUG TRANSPORTER (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24357">
        <property type="entry name" value="TMD0_ABC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="69"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="312"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="408"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="491"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="538"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="909"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="950"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1035"/>
            <end position="1068"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1137"/>
            <end position="1160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1166"/>
            <end position="1187"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="14">
        <location>
            <begin position="284"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="13">
        <location>
            <begin position="625"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="14">
        <location>
            <begin position="914"/>
            <end position="1195"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="13">
        <location>
            <begin position="1232"/>
            <end position="1471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="587"/>
            <end position="607"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OAG11742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1490" mass="164632" checksum="04BE9C99AE9BD23B" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CY23</accession>
    <name>A0A177CY23_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Concanavalin A-like lectin/glucanase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_53426</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG11792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042157.1">
        <property type="nucleotide sequence ID" value="XM_018186653.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CY23"/>
    <dbReference type="STRING" id="1460663.A0A177CY23"/>
    <dbReference type="GeneID" id="28770139"/>
    <dbReference type="InParanoid" id="A0A177CY23"/>
    <dbReference type="OrthoDB" id="4388755at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00413">
        <property type="entry name" value="Glyco_hydrolase_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38121:SF2">
        <property type="entry name" value="ACYLTRANSFERASE 3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38121">
        <property type="entry name" value="GH16 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00722">
        <property type="entry name" value="Glyco_hydro_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0430">Lectin</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GH16" evidence="2">
        <location>
            <begin position="5"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="237"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG11792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="278" mass="29817" checksum="472C95E72AA809EA" modified="2016-09-07" version="1">MLGLYAEDQVTTETTTFENGIDSSKWVVDTRGYGGSVDNPYMRQMDPKNVEVADGLLKLKVPGGQTYDPKGTVGLSSAQIKSVKIFSVGSLEMTVKMTSEKGTCQCGFLYGADNNEVDLEYLTRTNVSWGVVQGMSKDQPIQQVNLNVTTDQTDDFHTYKLVRTESKAYFLIDGQLVNTFDKNIPTEPVQAMLAHWTDANPGWTGGPPAKDAVMSIKKVVVEYVGETSIFSTSTGVPSATQSPGSSPSASGKSAASRGFTLNAGSLLAVAALCSYFVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CY74</accession>
    <name>A0A177CY74_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1254478</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042516.1">
        <property type="nucleotide sequence ID" value="XM_018184466.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CY74"/>
    <dbReference type="GeneID" id="28767952"/>
    <dbReference type="InParanoid" id="A0A177CY74"/>
    <dbReference type="OrthoDB" id="3790454at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG12151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="305" mass="34778" checksum="4DD1BEFFCEBAD8B1" modified="2016-09-07" version="1">MTQPTNRRTMSVARTDSIFVDTPAGTLERALSEKPDLELIHIPSHYLLPPTHPSPFEGTLEASLDALLDFGRAHPNSISIMNVLRQSVTTTTNWRDLLVPILELEEKTAMGNGRLLLEELLFLATRTLLPEQIAQNRACMHRMYAAKRTTSTRMILRYDMLREWAKRANNHFIVVESHPPLGNLEASVAAAEEEDKVHPGRRPALPNIWATLIAAPVQGYHVYKVGQAMKHHVTGLDKWLMFEDEEVAGWNTDTLVQLVMQALLQWQWLRDNTERMESMEVKGWGDLEGRADECEWVRDDKRAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CYQ1</accession>
    <name>A0A177CYQ1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 14">Tubulin beta chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CC84DRAFT_1159957</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13 14">Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4 14">Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the tubulin family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018043049.1">
        <property type="nucleotide sequence ID" value="XM_018177369.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CYQ1"/>
    <dbReference type="FunCoup" id="A0A177CYQ1">
        <property type="interactions" value="1244"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CYQ1"/>
    <dbReference type="GeneID" id="28760855"/>
    <dbReference type="InParanoid" id="A0A177CYQ1"/>
    <dbReference type="OrthoDB" id="1662883at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000070">
        <property type="term" value="P:mitotic sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097435">
        <property type="term" value="P:supramolecular fiber organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02187">
        <property type="entry name" value="beta_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.600:FF:000003">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.20:FF:000002">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1440:FF:000009">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013838">
        <property type="entry name" value="Beta-tubulin_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002453">
        <property type="entry name" value="Beta_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01163">
        <property type="entry name" value="BETATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00228">
        <property type="entry name" value="TUBULIN_B_AUTOREG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11 14" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 14" id="KW-0493">Microtubule</keyword>
    <keyword evidence="9 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="16">
        <location>
            <begin position="47"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="17">
        <location>
            <begin position="246"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="425"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="432"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="OAG12684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="447" mass="49846" checksum="F52DDC362E0960D1" modified="2016-09-07" version="1">MREIVHLQTGQCGNQIGAAFWQQISGEHGLDGSGVYNGTSDLQLERMNVYFNEATGNKFVPRAVLVDLEPGTMDAVRAGPFGQLFRPDNFVFGQSGAGNNWAKGHYTEGAELVDQVLDVVRREAEGCDCLQGFQITHSLGGGTGAGMGTLLISKIREEFPDRMMATFSVVPSPKVSDTVVEPYNATLSIHQLVENSDETFCIDNEALYDICMRTLKLNNPSYGDLNHLVSAVMSGVSTSLRFPGQLNSDLRKLAVNMVPFPRLHFFMVGFAPLTSRGAYSFRAVTVPELTQQMFDPKNMMAASDFRNGRYLTCSTIFRGKVSMKEVEDQMRNVQNKNSSYFVEWIPNNVQTALCSIPPRGLKMSSTFVGNSTSIQELFKRIGDQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQEASISEGEEEYDEEAPVEGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2023-06-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CYR3</accession>
    <name>A0A177CYR3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_71798</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042543.1">
        <property type="nucleotide sequence ID" value="XM_018187143.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CYR3"/>
    <dbReference type="GeneID" id="28770629"/>
    <dbReference type="InParanoid" id="A0A177CYR3"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG12178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="102" mass="11288" checksum="A8F744A76D7C203B" modified="2016-09-07" version="1">MDCPHVFGGLVEGRTPGVAGALSGHGKRESRCLSASVRDAPQPRFMCYLRFRDRSELPDELALSCWGHAGSKVATRRKAHVLTWLWLIAVASSRELRLCMHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2023-06-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CYY3</accession>
    <name>A0A177CYY3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_65289</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042405.1">
        <property type="nucleotide sequence ID" value="XM_018187008.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CYY3"/>
    <dbReference type="GeneID" id="28770494"/>
    <dbReference type="InParanoid" id="A0A177CYY3"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG12040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="206" mass="22959" checksum="A3B9240D63D43DFC" modified="2016-09-07" version="1">MMEERFVLGLYCLINTASSIIVVEAMEHHSLIHSQFQSLKLLGEIANDGFASVNEVSLRTVLAWDLSSRFRPRPQTASTTEIQAPVSYGVSASGQNRLQMRILLRHAGSMNHSCIETTISCRSMRFIPRSGGMNPLALLLFENITNKGSMEVLPIGPTPLRTHAVLWRLTYKSILRRVCNSEKVLCPGLKLRNKRLDGASVPKDLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CZP5</accession>
    <name>A0A177CZP5_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CC84DRAFT_123194</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042802.1">
        <property type="nucleotide sequence ID" value="XM_018183744.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CZP5"/>
    <dbReference type="STRING" id="1460663.A0A177CZP5"/>
    <dbReference type="GeneID" id="28767230"/>
    <dbReference type="InParanoid" id="A0A177CZP5"/>
    <dbReference type="OrthoDB" id="2571985at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000435">
        <property type="term" value="P:positive regulation of transcription from RNA polymerase II promoter by galactose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051127">
        <property type="entry name" value="Fungal_SecMet_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424:SF15">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="20"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="621"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="621"/>
            <end position="632"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAG12437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="694" mass="78415" checksum="ED0B803B01C14B76" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CZQ8</accession>
    <name>A0A177CZQ8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1159846</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042923.1">
        <property type="nucleotide sequence ID" value="XM_018177346.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CZQ8"/>
    <dbReference type="GeneID" id="28760832"/>
    <dbReference type="InParanoid" id="A0A177CZQ8"/>
    <dbReference type="OrthoDB" id="416585at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG12558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="139" mass="14930" checksum="9CF939893C23AE21" modified="2016-09-07" version="1">MNNTNGNTTSPRPECHYSKGNINTTSLPENGSWVAIADAYPNYTRAMAQCCGADHPSDFYGPDACFRYCNVTDGPDGRNVKNVSDCLTDTFGIPWWWVHSRAQYNHDLDGAAVRLGNGGGKMGLLVLIVGLLGVFGGGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177D086</accession>
    <name>A0A177D086_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Aldose reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CC84DRAFT_1183241</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018043012.1">
        <property type="nucleotide sequence ID" value="XM_018180678.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177D086"/>
    <dbReference type="STRING" id="1460663.A0A177D086"/>
    <dbReference type="GeneID" id="28764164"/>
    <dbReference type="InParanoid" id="A0A177D086"/>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004032">
        <property type="term" value="F:aldose reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006066">
        <property type="term" value="P:alcohol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019568">
        <property type="term" value="P:arabinose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033554">
        <property type="term" value="P:cellular response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042843">
        <property type="term" value="P:D-xylose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042180">
        <property type="term" value="P:ketone metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000018">
        <property type="entry name" value="Glycerol dehydrogenase Gcy1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11732">
        <property type="entry name" value="ALDO/KETO REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00798">
        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00063">
        <property type="entry name" value="ALDOKETO_REDUCTASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="8">
        <location>
            <begin position="22"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="7">
        <location>
            <position position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAG12647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="298" mass="33629" checksum="2BDC58759BAA1F3E" modified="2016-09-07" version="1">MAPKNWTKETFTLNTGAKIPAIGLGTWQSKPNEVREAVKAALQAGYRHIDTALAYGNEHEVGQGIKDSGVPREEIWITTKLDNPWHKRVEEGINSSLKSLGVDYVDLYLMHWPSSTDPEDLKKHYPDWDFTDTWRELQKLPESGRVKNIGVSNFAIKNLEKLFASKDFKTTPAVNQIELHPNNPSPKLLDYLKEKGIHATAYSCLGSTDSPLYKNEELKKIAEKKGKTVQQVLLMWGLQRGTSVIPKSVTASRIQANFEVDGWELTEEEQKAISGLTERFKVCGDSWLPVKVFFGDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177D0E2</accession>
    <name>A0A177D0E2_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Threonine synthase</fullName>
            <ecNumber evidence="5">4.2.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CC84DRAFT_1159967</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>O-phospho-L-homoserine + H2O = L-threonine + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10840"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57590"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="EC" id="4.2.3.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:10841"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 5/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the threonine synthase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.1" evidence="5"/>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018043062.1">
        <property type="nucleotide sequence ID" value="XM_018177372.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177D0E2"/>
    <dbReference type="FunCoup" id="A0A177D0E2">
        <property type="interactions" value="255"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177D0E2"/>
    <dbReference type="GeneID" id="28760858"/>
    <dbReference type="InParanoid" id="A0A177D0E2"/>
    <dbReference type="OrthoDB" id="5203861at2759"/>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00065"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004795">
        <property type="term" value="F:threonine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01560">
        <property type="entry name" value="Thr-synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000046">
        <property type="entry name" value="THR4p Threonine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1380.10:FF:000003">
        <property type="entry name" value="THR4p Threonine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1380.10">
        <property type="entry name" value="Threonine synthase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000634">
        <property type="entry name" value="Ser/Thr_deHydtase_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029144">
        <property type="entry name" value="Thr_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037158">
        <property type="entry name" value="Thr_synth_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004450">
        <property type="entry name" value="Thr_synthase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051166">
        <property type="entry name" value="Threonine_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00260">
        <property type="entry name" value="thrC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42690">
        <property type="entry name" value="THREONINE SYNTHASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42690:SF1">
        <property type="entry name" value="THREONINE SYNTHASE-LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24857">
        <property type="entry name" value="THR4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14821">
        <property type="entry name" value="Thr_synth_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00165">
        <property type="entry name" value="DEHYDRATASE_SER_THR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0456">Lyase</keyword>
    <keyword evidence="9 12" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0791">Threonine biosynthesis</keyword>
    <feature type="domain" description="Threonine synthase N-terminal" evidence="14">
        <location>
            <begin position="9"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="13">
        <location>
            <begin position="97"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="12">
        <location>
            <position position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00050436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR604450-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF14821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OAG12697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="547" mass="60557" checksum="85C32E465C70996A" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177D0Z9</accession>
    <name>A0A177D0Z9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HMG box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1212203</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018043054.1">
        <property type="nucleotide sequence ID" value="XM_018182433.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177D0Z9"/>
    <dbReference type="STRING" id="1460663.A0A177D0Z9"/>
    <dbReference type="GeneID" id="28765919"/>
    <dbReference type="InParanoid" id="A0A177D0Z9"/>
    <dbReference type="OrthoDB" id="1919336at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00084">
        <property type="entry name" value="HMG-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="2">
        <location>
            <begin position="143"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="HMG box" evidence="2">
        <location>
            <begin position="246"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG12689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="310" mass="34096" checksum="52A0C68E75AA5E95" modified="2016-09-07" version="1">MLARGALCRLAADVPKTSTHDLPRISQLLRTTLFARHGASQPTVGAIVRAFRTTILEGRRAYATKSATEPTARVKREVKKAVATKKTAKTTTAKKTTTKKAAPKKAKKVAPKKKKPAKELTAEQKEAQTIKKLKERALLKGSPKRSNSSAWTEFASESLKGSKNIEDSQSIMKEAAVKYKNLTPAEREHYNQLAKQNMDAKLAAYDKWILSHTPEEIAAANYARAALKRKLGLKSKYDTLIDPRHNKAARSGPFVLFAKERLSSGEYQGIVVQERMKLVANEWKALSPSEKKVFEDQSAAAKAAAAKTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BUB6</accession>
    <name>A0A177BUB6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_429805</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441566">
        <property type="protein sequence ID" value="OAF98570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018028936.1">
        <property type="nucleotide sequence ID" value="XM_018186214.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BUB6"/>
    <dbReference type="GeneID" id="28769700"/>
    <dbReference type="InParanoid" id="A0A177BUB6"/>
    <dbReference type="OrthoDB" id="3800164at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="147"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="41"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="125"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAF98570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="316" mass="35414" checksum="B7D6BBDDB223FE81" modified="2016-09-07" version="1">MVVDNTHSIHDGADRKKGYTQRAEDNDAVAGQGDEEDPNEEERRQESRAQEDSGKKTCTEETCSEVRDHEEPGHSAARAASVLPGHQKSHVAPRSKAQEGTQPPRHHRSHPPNAHRADHPPQKPSMLTRNTLLPDPSTLTPEQRAVVERHEKQLAWQKKELARQKRASDKRAEEIRTKGYHYKGRWVPLQQRPDFVVKVEAGEEGEEILVKAEADDRAGSGMVRSALANRPRATRADIAQVTLSSLLATPHPSTTAGNRRRRVGGPDITKSFDKQYPLIAERVENEMLDEADDAGSLCEFVTADEWDDRENMYLDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BUT5</accession>
    <name>A0A177BUT5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HET-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1169379</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441562">
        <property type="protein sequence ID" value="OAF99233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029599.1">
        <property type="nucleotide sequence ID" value="XM_018179646.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BUT5"/>
    <dbReference type="STRING" id="1460663.A0A177BUT5"/>
    <dbReference type="GeneID" id="28763132"/>
    <dbReference type="InParanoid" id="A0A177BUT5"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF73">
        <property type="entry name" value="HET DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_8G01020)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="59"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAF99233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="394" mass="44994" checksum="1F6A35D55A232A31" modified="2016-09-07" version="1">MAGNISALQALPIDASGTSIRLLKVEPKSRDRFQSQSKELLSLSTEVFGLDDRARYHAYRALSYTWGPPEPTKAIALNGIVIRIRKNLFDFLDMYAHEQPDECKYLWIDQLCIDQNNTQERNHQVGIMHRIYAEAYEVVAWLGLDEDGSERVMKCLSGFSDVAFLGDSRLRGVMKDDKRKMLLENFEAVKALLGRDYWGRLWIIQEVLLAVRLKVYCGRLHCDGADFESLLGLMMIANDRIPRGTQTNIFGEEMWQSNPITYRNSLLANMDISEALLRFSEASCVDPRDKIFGLGAIISSSHDLTIDYGMSCEEVYMDTCCKLYETDRREVAYEALRCLSVQAKLHVSLELASDIEQLVRLKKWPENSSRHLEIFRKYLQRYSAVDAAPSVSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BV21</accession>
    <name>A0A177BV21_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">O-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CC84DRAFT_1222944</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441562">
        <property type="protein sequence ID" value="OAF99242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029608.1">
        <property type="nucleotide sequence ID" value="XM_018183442.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BV21"/>
    <dbReference type="GeneID" id="28766928"/>
    <dbReference type="InParanoid" id="A0A177BV21"/>
    <dbReference type="OrthoDB" id="1606438at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016461">
        <property type="entry name" value="COMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001077">
        <property type="entry name" value="COMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712:SF17">
        <property type="entry name" value="O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00891">
        <property type="entry name" value="Methyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51683">
        <property type="entry name" value="SAM_OMT_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="O-methyltransferase C-terminal" evidence="4">
        <location>
            <begin position="241"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAF99242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="403" mass="44682" checksum="EE77480CCEBFC1EF" modified="2016-09-07" version="1">MADTPPSQGALALVESITKLGEGLKNGERGARESLLGACSKLIAELSHPSETMLHLLWAQPAHLSVIRMGVEIKLFQAMQDIDAVGETTAEIASRTDPKTDPVLVGRMLRHLAAMNTVNETAPDTFAPTATSKSFAEPVYQDTILYIIDNFQPAHQKMPSFFQTHGFTTPNSQTDGPFQHAFNCKGYHYFEYFQKFDQEMGRRFGSMMDAWSKGRPRWFEPEFYPVKEQLIAGAECDGVFLVDVGGGVGHDVEGLREAFGSALPGKLVLQDRPEVVEHAQIGEGAEKMAHDFLTEQPVKGARAYYFHSIIQDWSDDVNTQILKAIVPAMKKGYSKVLVNDFVVPNQGAAWPQTALDWELMASLGARHRTVTEHTKLYEGAGLRITGIWRHPHSLDSLIELELA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BV63</accession>
    <name>A0A177BV63_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Peptidase S28</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CC84DRAFT_1182004</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S28 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441564">
        <property type="protein sequence ID" value="OAF98860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029226.1">
        <property type="nucleotide sequence ID" value="XM_018180591.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BV63"/>
    <dbReference type="GeneID" id="28764077"/>
    <dbReference type="InParanoid" id="A0A177BV63"/>
    <dbReference type="OrthoDB" id="1735038at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070008">
        <property type="term" value="F:serine-type exopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000636">
        <property type="entry name" value="Serine peptidase, family S28, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008758">
        <property type="entry name" value="Peptidase_S28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11010:SF109">
        <property type="entry name" value="PEPTIDASE, FAMILY S28, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G03790)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11010">
        <property type="entry name" value="PROTEASE S28 PRO-X CARBOXYPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05577">
        <property type="entry name" value="Peptidase_S28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008057353" description="Peptidase S28" evidence="6">
        <location>
            <begin position="23"/>
            <end position="574"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAF98860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="574" mass="63364" checksum="670EF745032DEBEF" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BWE2</accession>
    <name>A0A177BWE2_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1181977</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441564">
        <property type="protein sequence ID" value="OAF98827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029193.1">
        <property type="nucleotide sequence ID" value="XM_018180588.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BWE2"/>
    <dbReference type="STRING" id="1460663.A0A177BWE2"/>
    <dbReference type="GeneID" id="28764074"/>
    <dbReference type="InParanoid" id="A0A177BWE2"/>
    <dbReference type="OrthoDB" id="2991872at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053175">
        <property type="entry name" value="DHMBA_Reg_Transcription_Factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38791">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="2">
        <location>
            <begin position="9"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAF98827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="487" mass="54481" checksum="AF072AB1F2554F10" modified="2016-09-07" version="1">MSRPIWSTGCHACRKMKKKCDGAKPGCVRCKKAGRECPGYRSAQQVMFRSMNESAMARANKPTMLATISGGYNPFFIQPSTDWAQFAISHFVYHYVEPPSEYGLPGYLEFLPTMLNSADSSLQTSLLAASLANLANVSGMEQLHTESRIQYGRALRSLHTALSDKATATDDHTLLAVVLLQKYETITGNVDLEKDPHEKATTAMMRLRRPDHESLSNRSSSLSRVVLIRKEIKAMTDRTDSNMEVGERYVDTKQTVGSGLRMLLRDVFIASRGLEVCTEAQDIATGSHMTAFTEAWKFAVEVYNHLILWPSTVPPAWKMKAYVFPMTPSHIDGLTNREGQVYAFSSLQHGAVYGAYQCSRINICQSLRKAYRFIHQQPRQLFDSNFEPSQGEVLETLNSAVDDIFGTSPFMLGDVTSNGQLNATNERRALGAFFLLRSVYVALSVDTLTQPQSRKLLHLLGRIGSEFGIKTASNRRDKWLAQHPDRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BWV1</accession>
    <name>A0A177BWV1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">mitogen-activated protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CC84DRAFT_1222634</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:17990"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:46609"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.24" evidence="2"/>
    <dbReference type="EMBL" id="KV441561">
        <property type="protein sequence ID" value="OAF99615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029981.1">
        <property type="nucleotide sequence ID" value="XM_018183398.1"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177BWV1"/>
    <dbReference type="GeneID" id="28766884"/>
    <dbReference type="InParanoid" id="A0A177BWV1"/>
    <dbReference type="OrthoDB" id="266718at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004707">
        <property type="term" value="F:MAP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004709">
        <property type="term" value="F:MAP kinase kinase kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000196">
        <property type="term" value="P:cell integrity MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000182">
        <property type="entry name" value="MAP kinase kinase kinase mkh1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000387">
        <property type="entry name" value="Serine/threonine-protein kinase STE11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050538">
        <property type="entry name" value="MAP_kinase_kinase_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016">
        <property type="entry name" value="MAP KINASE KINASE KINASE SSK2-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016:SF48">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE BCK1_SLK1_SSP31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="1498"/>
            <end position="1767"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="100"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="420"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="505"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="585"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="850"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="933"/>
            <end position="1044"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1057"/>
            <end position="1112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1137"/>
            <end position="1182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1203"/>
            <end position="1306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1350"/>
            <end position="1385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="132"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="166"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="455"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="600"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="625"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="660"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="687"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="861"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="993"/>
            <end position="1004"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1019"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1057"/>
            <end position="1067"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1089"/>
            <end position="1106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1237"/>
            <end position="1259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1260"/>
            <end position="1270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1371"/>
            <end position="1385"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="1527"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OAF99615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="1789" mass="193824" checksum="182F3836EBF72857" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BWZ6</accession>
    <name>A0A177BWZ6_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">cAMP-dependent protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">CC84DRAFT_1191189</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.11"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.11" evidence="1"/>
    <dbReference type="EMBL" id="KV441562">
        <property type="protein sequence ID" value="OAF99208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029574.1">
        <property type="nucleotide sequence ID" value="XM_018181168.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BWZ6"/>
    <dbReference type="FunCoup" id="A0A177BWZ6">
        <property type="interactions" value="902"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177BWZ6"/>
    <dbReference type="GeneID" id="28764654"/>
    <dbReference type="InParanoid" id="A0A177BWZ6"/>
    <dbReference type="OrthoDB" id="63267at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005952">
        <property type="term" value="C:cAMP-dependent protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004691">
        <property type="term" value="F:cAMP-dependent protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010619">
        <property type="term" value="P:adenylate cyclase-activating glucose-activated G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045721">
        <property type="term" value="P:negative regulation of gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010515">
        <property type="term" value="P:negative regulation of induction of conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046827">
        <property type="term" value="P:positive regulation of protein export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd05580">
        <property type="entry name" value="STKc_PKA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000005">
        <property type="entry name" value="cAMP-dependent protein kinase catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000005">
        <property type="entry name" value="cAMP-dependent protein kinase catalytic subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353:SF153">
        <property type="entry name" value="CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-DEPENDENT PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="157"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="13">
        <location>
            <begin position="413"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="115"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="17"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="57"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="76"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="115"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="OAF99208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="468" mass="52172" checksum="2A957E36B2D6489C" modified="2016-09-07" version="1">MPSLGFLKKKKTRDSTDSPTSPVKDSTTSPIFPTTSKTQRASVVSKASTKTNPDTLAQQPAQGSQASAGASHKQVDSMNSQPQQAYATPQASPEPYQSASHNVPSIQNLIHPTNANAAPASSQQPQQPAKPANGALQTAQPPAQPRVTKGKYTLQDFAIQRTLGTGSFGRVHLVQSKHNQRYYAVKVLKKAQVVKMKQVEHTNDERRMLQQVKHPFLITLWGTFQDSKNLYMVMDFVEGGELFSLLRKSQRFPNPVAKFYAAEVTLALDYLHAQNIIYRDLKPENLLLDRHGHLKITDFGFAKEVPDITWTLCGTPDYLAPEVVASKGYNKSVDWWSLGILIFEMLCGFTPFWDGGSPMKIYENILKGRVKYPPYIHPDAQDLLQKLITPDLTKRLGNLHGGSKDVMNHPWFAEVTWERLQKKDIDAPYVPPVRAGVGDASQFDKYPEETEAYGQTGEDPHGPLFLDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BX17</accession>
    <name>A0A177BX17_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">DNA 3'-5' helicase</fullName>
            <ecNumber evidence="11">5.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CC84DRAFT_1209997</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the helicase family. RecQ subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="11"/>
    <dbReference type="EMBL" id="KV441561">
        <property type="protein sequence ID" value="OAF99685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030051.1">
        <property type="nucleotide sequence ID" value="XM_018182257.1"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177BX17"/>
    <dbReference type="GeneID" id="28765743"/>
    <dbReference type="InParanoid" id="A0A177BX17"/>
    <dbReference type="OrthoDB" id="10261556at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031422">
        <property type="term" value="C:RecQ family helicase-topoisomerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000729">
        <property type="term" value="P:DNA double-strand break processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031573">
        <property type="term" value="P:mitotic intra-S DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006312">
        <property type="term" value="P:mitotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17920">
        <property type="entry name" value="DEXHc_RecQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18794">
        <property type="entry name" value="SF2_C_RecQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000296">
        <property type="entry name" value="ATP-dependent DNA helicase RecQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000340">
        <property type="entry name" value="Bloom syndrome, RecQ helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.80">
        <property type="entry name" value="HRDC domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004589">
        <property type="entry name" value="DNA_helicase_ATP-dep_RecQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010997">
        <property type="entry name" value="HRDC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002121">
        <property type="entry name" value="HRDC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044876">
        <property type="entry name" value="HRDC_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032284">
        <property type="entry name" value="RecQ_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018982">
        <property type="entry name" value="RQC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00614">
        <property type="entry name" value="recQ_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710">
        <property type="entry name" value="DNA HELICASE RECQ FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710:SF153">
        <property type="entry name" value="RECQ-LIKE DNA HELICASE BLM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00570">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16124">
        <property type="entry name" value="RecQ_Zn_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09382">
        <property type="entry name" value="RQC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00956">
        <property type="entry name" value="RQC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47819">
        <property type="entry name" value="HRDC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50967">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 18" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="16">
        <location>
            <begin position="575"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="17">
        <location>
            <begin position="782"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodanese" evidence="14">
        <location>
            <begin position="797"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="domain" description="HRDC" evidence="15">
        <location>
            <begin position="1201"/>
            <end position="1284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="108"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="340"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="497"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1066"/>
            <end position="1187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1296"/>
            <end position="1317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1350"/>
            <end position="1371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1384"/>
            <end position="1480"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="256"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="113"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="151"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="168"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="340"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="497"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="1083"/>
            <end position="1100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="1300"/>
            <end position="1310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="1407"/>
            <end position="1417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1435"/>
            <end position="1458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="1459"/>
            <end position="1472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="OAF99685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="1480" mass="164971" checksum="2AAF43A6EF3A4B34" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BX26</accession>
    <name>A0A177BX26_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HET-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1131026</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441562">
        <property type="protein sequence ID" value="OAF99238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029604.1">
        <property type="nucleotide sequence ID" value="XM_018175880.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BX26"/>
    <dbReference type="STRING" id="1460663.A0A177BX26"/>
    <dbReference type="GeneID" id="28759366"/>
    <dbReference type="InParanoid" id="A0A177BX26"/>
    <dbReference type="OrthoDB" id="20872at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF11">
        <property type="entry name" value="HET-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
        <property type="entry name" value="NB-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="2">
        <location>
            <begin position="27"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="NB-ARC" evidence="1">
        <location>
            <begin position="284"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="696"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAF99238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="696" mass="78893" checksum="CDE230FD801A5F74" modified="2016-09-07" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BX61</accession>
    <name>A0A177BX61_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1169693</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441563">
        <property type="protein sequence ID" value="OAF98966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029332.1">
        <property type="nucleotide sequence ID" value="XM_018179727.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BX61"/>
    <dbReference type="STRING" id="1460663.A0A177BX61"/>
    <dbReference type="GeneID" id="28763213"/>
    <dbReference type="InParanoid" id="A0A177BX61"/>
    <dbReference type="OrthoDB" id="2420608at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018465">
        <property type="entry name" value="Scm3/HJURP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10384">
        <property type="entry name" value="Scm3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="606"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="254"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="431"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="637"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="435"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="472"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="533"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="575"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="642"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="668"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="686"/>
            <end position="701"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAF98966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="761" mass="83359" checksum="71EF101546FE2635" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BY01</accession>
    <name>A0A177BY01_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1104677</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441562">
        <property type="protein sequence ID" value="OAF99209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029575.1">
        <property type="nucleotide sequence ID" value="XM_018175068.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BY01"/>
    <dbReference type="STRING" id="1460663.A0A177BY01"/>
    <dbReference type="GeneID" id="28758554"/>
    <dbReference type="InParanoid" id="A0A177BY01"/>
    <dbReference type="OrthoDB" id="2378324at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3210.10">
        <property type="entry name" value="Hypothetical protein af1432"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35569">
        <property type="entry name" value="CYANAMIDE HYDRATASE DDI2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35569:SF1">
        <property type="entry name" value="CYANAMIDE HYDRATASE DDI2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAF99209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="238" mass="26257" checksum="6B30EB9BA171B246" modified="2016-09-07" version="1">MVAISHLLTRVIAGIPVPNTPLINSSIALTRAALPDQGYNHVMRSWLNGQAIINNLPATNRSKIDQEAFGIATILHDLGWSNDTTYISPDKRFEIDGAIAARTFLQAHGGPTWRSAQRLQLVFDIIALHSTASIARYKQPEVAIASGGILTELLGPSVARTSFGELITVSQAQWEDIARAYPREDVKEYFNGVMVGLCTMKPDTTWDNFVSDYGEVLIEGFNRTGHRTVDLTQMYLVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BYC2</accession>
    <name>A0A177BYC2_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">6,7-dimethyl-8-ribityllumazine synthase</fullName>
            <shortName evidence="7">DMRL synthase</shortName>
            <ecNumber evidence="3 7">2.5.1.78</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_1155401</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>(2S)-2-hydroxy-3-oxobutyl phosphate + 5-amino-6-(D-ribitylamino)uracil = 6,7-dimethyl-8-(1-D-ribityl)lumazine + phosphate + 2 H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:26152"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15934"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58201"/>
            <dbReference type="ChEBI" id="CHEBI:58830"/>
            <dbReference type="EC" id="2.5.1.78"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 7">Cofactor biosynthesis; riboflavin biosynthesis; riboflavin from 2-hydroxy-3-oxobutyl phosphate and 5-amino-6-(D-ribitylamino)uracil: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the DMRL synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.78" evidence="3 7"/>
    <dbReference type="EMBL" id="KV441559">
        <property type="protein sequence ID" value="OAG00514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030879.1">
        <property type="nucleotide sequence ID" value="XM_018176933.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BYC2"/>
    <dbReference type="FunCoup" id="A0A177BYC2">
        <property type="interactions" value="284"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177BYC2"/>
    <dbReference type="GeneID" id="28760419"/>
    <dbReference type="InParanoid" id="A0A177BYC2"/>
    <dbReference type="OrthoDB" id="2965at2759"/>
    <dbReference type="UniPathway" id="UPA00275">
        <property type="reaction ID" value="UER00404"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009349">
        <property type="term" value="C:riboflavin synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000906">
        <property type="term" value="F:6,7-dimethyl-8-ribityllumazine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd09209">
        <property type="entry name" value="Lumazine_synthase-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.960:FF:000005">
        <property type="entry name" value="6,7-dimethyl-8-ribityllumazine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.960">
        <property type="entry name" value="Lumazine/riboflavin synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00178">
        <property type="entry name" value="Lumazine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034964">
        <property type="entry name" value="LS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002180">
        <property type="entry name" value="LS/RS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036467">
        <property type="entry name" value="LS/RS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21058:SF0">
        <property type="entry name" value="6,7-DIMETHYL-8-RIBITYLLUMAZINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21058">
        <property type="entry name" value="6,7-DIMETHYL-8-RIBITYLLUMAZINE SYNTHASE DMRL SYNTHASE LUMAZINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00885">
        <property type="entry name" value="DMRL_synthase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52121">
        <property type="entry name" value="Lumazine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0686">Riboflavin biosynthesis</keyword>
    <keyword evidence="5 7" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAG00514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="208" mass="21859" checksum="FA965F0C387AFAE4" modified="2016-09-07" version="1">MTTLKGPGEAKTYDGSGLRIGIIHARWNTKIIDALLDGTKKALKAAGVKDENIVLQSVPGSYELPYAVKQLYAASQAQASSSTVIGAAADLLGSVSDLSTEPSKPISSTLSTPFDAIIAIGVLIKGETMHFEYIADAVSHGLMRVQLDNNVPLIFGLLTLLSDEQGLQRAGIGGASGKEGHNHGEDWGSAAVELGVKRKGWVEGKYVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BYF7</accession>
    <name>A0A177BYF7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">FAD/NAD(P)-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CC84DRAFT_312241</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441559">
        <property type="protein sequence ID" value="OAG00554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030919.1">
        <property type="nucleotide sequence ID" value="XM_018185821.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BYF7"/>
    <dbReference type="GeneID" id="28769307"/>
    <dbReference type="InParanoid" id="A0A177BYF7"/>
    <dbReference type="OrthoDB" id="66881at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050775">
        <property type="entry name" value="FAD-binding_Monooxygenases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43098:SF5">
        <property type="entry name" value="DUAL-FUNCTIONAL MONOOXYGENASE_METHYLTRANSFERASE PSOF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43098">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAG00554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="538" mass="61810" checksum="6DA54FE19A5C261B" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BYY3</accession>
    <name>A0A177BYY3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CC84DRAFT_1180704</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441559">
        <property type="protein sequence ID" value="OAG00734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031099.1">
        <property type="nucleotide sequence ID" value="XM_018180500.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BYY3"/>
    <dbReference type="STRING" id="1460663.A0A177BYY3"/>
    <dbReference type="GeneID" id="28763986"/>
    <dbReference type="InParanoid" id="A0A177BYY3"/>
    <dbReference type="OrthoDB" id="3926200at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="99"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="128"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="174"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="211"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAG00734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="353" mass="39928" checksum="725A96A3DBC26114" modified="2016-09-07" version="1">MEYDYVPLFFGNSHPASQAWAVFTAFSAVGSMISVTYTCVRVKQTIAWTNILPWSPLWRSSAPVSRREPKDYLELRILNNQHAHNPYDLSTGEPQGGLILHWIICVVYICATSAISVVTEAIAFPGQLLSYAHAIVGVVLGVMFPKFRSIENKVPMTRQWDPPSRESRWLKLKFAPIIFGWTYAIGSIALLVLTVIGPYKNADGSERVVKGWFYPAVSFGTLLMSLIYYLIFIASTEASLVRAAGIQIRECRHGENDRERIRRRCDVCQDSPQAHRHARDGYEHYFEVVVPDTHDRGSFLYWFFGGTEERHHPRASEQVNMVRAVFAQAKAHLKEMFRKPSGLSRNGGANGDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BZB7</accession>
    <name>A0A177BZB7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_383153</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441561">
        <property type="protein sequence ID" value="OAF99786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030152.1">
        <property type="nucleotide sequence ID" value="XM_018185987.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BZB7"/>
    <dbReference type="GeneID" id="28769473"/>
    <dbReference type="InParanoid" id="A0A177BZB7"/>
    <dbReference type="OrthoDB" id="4149149at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAF99786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="388" mass="44338" checksum="7DCCB309ADCDF646" modified="2016-09-07" version="1">MARSLDTSMGDPERELADALEAHRGSGGEPLAGLFNLTRRMENEQEEQFDVDLTIMDFLAYKATDLVFEWRAGSNPHQSDLPSALVTMTAEWRTFLKHKHSGKRLNSQAAFRSRLLQFSLLFTHRLNHEQTWTTEESLNELRAQNRKRGQYWNDAGRTPALQRPFDPSSEFPLADGALAENRHNLACAIDQPQERRRWVTDLEGTPTLHCLLPLFVELTAARVQLGDWVPSEGWMDLMGQFMLHAVLEEYLLNGAYSQETFNTIFAFGCPGTEHRSDEGGDVVAMRSIFCSDAHPHQEIPGWSEVRQRYVQELLPPPNSSTSFVQAMERAQELHPYEAFENSTIAFLEYLHDELIKPDLVQVEEGRVNIHGNELPESDSREMIRRMGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C082</accession>
    <name>A0A177C082_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">xylan 1,4-beta-xylosidase</fullName>
            <ecNumber evidence="14">3.2.1.37</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">1,4-beta-D-xylan xylohydrolase xlnD</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">Beta-xylosidase A</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Beta-xylosidase xlnD</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Xylobiase xlnD</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">CC84DRAFT_1229723</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Xylan 1,4-beta-xylosidase involved in the hydrolysis of xylan, a major structural heterogeneous polysaccharide found in plant biomass representing the second most abundant polysaccharide in the biosphere, after cellulose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>Hydrolysis of (1-&gt;4)-beta-D-xylans, to remove successive D-xylose residues from the non-reducing termini.</text>
            <dbReference type="EC" id="3.2.1.37"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Glycan degradation; xylan degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.37" evidence="14"/>
    <dbReference type="EMBL" id="KV441558">
        <property type="protein sequence ID" value="OAG01053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031418.1">
        <property type="nucleotide sequence ID" value="XM_018183671.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C082"/>
    <dbReference type="STRING" id="1460663.A0A177C082"/>
    <dbReference type="GeneID" id="28767157"/>
    <dbReference type="InParanoid" id="A0A177C082"/>
    <dbReference type="OrthoDB" id="47059at2759"/>
    <dbReference type="UniPathway" id="UPA00114"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046556">
        <property type="term" value="F:alpha-L-arabinofuranosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009044">
        <property type="term" value="F:xylan 1,4-beta-xylosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031222">
        <property type="term" value="P:arabinan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1700:FF:000007">
        <property type="entry name" value="Exo-1,4-beta-xylosidase xlnD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044993">
        <property type="entry name" value="BXL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42721:SF13">
        <property type="entry name" value="EXO-1,4-BETA-XYLOSIDASE XLND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42721">
        <property type="entry name" value="SUGAR HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="Beta-D-glucan exohydrolase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 19" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0858">Xylan degradation</keyword>
    <feature type="signal peptide" evidence="19">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008057539" description="xylan 1,4-beta-xylosidase" evidence="19">
        <location>
            <begin position="19"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type III-like" evidence="20">
        <location>
            <begin position="690"/>
            <end position="760"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00025331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00026107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00041508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00041545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00041684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00042744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="SMART" id="SM01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="OAG01053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="787" mass="84820" checksum="6FABD7A88F9DE9E1" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C0H6</accession>
    <name>A0A177C0H6_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">gamma-glutamylcyclotransferase</fullName>
            <ecNumber evidence="1">4.3.2.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CC84DRAFT_1190450</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EC" id="4.3.2.9" evidence="1"/>
    <dbReference type="EMBL" id="KV441559">
        <property type="protein sequence ID" value="OAG00342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030707.1">
        <property type="nucleotide sequence ID" value="XM_018181119.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C0H6"/>
    <dbReference type="STRING" id="1460663.A0A177C0H6"/>
    <dbReference type="GeneID" id="28764605"/>
    <dbReference type="InParanoid" id="A0A177C0H6"/>
    <dbReference type="OrthoDB" id="2017317at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003839">
        <property type="term" value="F:gamma-glutamylcyclotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.490.10">
        <property type="entry name" value="Gamma-glutamyl cyclotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017939">
        <property type="entry name" value="G-Glutamylcylcotransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12935">
        <property type="entry name" value="GAMMA-GLUTAMYLCYCLOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12935:SF0">
        <property type="entry name" value="GAMMA-GLUTAMYLCYCLOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="242"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="272"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="145"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="48"/>
            <end position="53"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR617939-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR617939-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAG00342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="340" mass="38284" checksum="59326A6A1AA14A6E" modified="2016-09-07" version="1">MTQRVFPRISQTSPERRDASLTEPSFDVKALSPSDIDAASEKGKTILYLAYGSNLCKETFREKRGIKPLSQINVLVPSLRLTFDLPGVPYIEPCFGNSAMREPDAMQDPDAMDSEDYHKDRWKKGLVGCVYEVTPSDYAQIIATEGGGAGYQDILVDCYPLPDGDTVPEKPTTQRFLAHTLFAPPEKSHARPDPSYAQPSARYLNLITTGAAELSLPREYQLYLNEIRPYTITTKKQQMGKVLFASIWLPFLQLLFALNAQFQDDKGRSPPWLAQLAALLFLGIWRCYDGAFKKVFGDGERTKGGETSSKKGDEMDEAQWRRIGENNGWFRSHEKIEHMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C0T0</accession>
    <name>A0A177C0T0_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Alpha/beta-hydrolase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1128002</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441558">
        <property type="protein sequence ID" value="OAG00821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031186.1">
        <property type="nucleotide sequence ID" value="XM_018175785.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C0T0"/>
    <dbReference type="STRING" id="1460663.A0A177C0T0"/>
    <dbReference type="GeneID" id="28759271"/>
    <dbReference type="InParanoid" id="A0A177C0T0"/>
    <dbReference type="OrthoDB" id="2141514at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33428:SF14">
        <property type="entry name" value="CARBOXYLESTERASE TYPE B DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33428">
        <property type="entry name" value="CHLOROPHYLLASE-2, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008057588" description="Alpha/beta-hydrolase" evidence="1">
        <location>
            <begin position="20"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG00821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="276" mass="28754" checksum="2DCA70E97216A62E" modified="2016-09-07" version="1">MKHTLALALMAFSLDAATASPLNVEARQGAGSGAGPYAPGTYKTDSSLQSHTIYYPTKTPANNEKLPVLIWGNGGCSNVGTSNSALLQNIASYGFLAVAEGAPSGGGTSNSASMKAAVDWVTKTAGTGAYANVDASKIMAAGFSCGGTEAMDNVWDSRVDTIGVISSGLLSNYTAASQWRKPVLFVLGGSSDIAYQNGERDFKNLAAGVPSWKGNINVGHGGTLNNANGGTFGKAILNWLLWTFKNDTTAASYFTSGYKADNWQVETHDLDQLKPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C161</accession>
    <name>A0A177C161_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_315685</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441559">
        <property type="protein sequence ID" value="OAG00572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030937.1">
        <property type="nucleotide sequence ID" value="XM_018185825.1"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177C161"/>
    <dbReference type="GeneID" id="28769311"/>
    <dbReference type="InParanoid" id="A0A177C161"/>
    <dbReference type="OrthoDB" id="10256089at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031991">
        <property type="term" value="P:regulation of actomyosin contractile ring contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032955">
        <property type="term" value="P:regulation of division septum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07589">
        <property type="entry name" value="BAR_DNMBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051492">
        <property type="entry name" value="Dynamin-Rho_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001331">
        <property type="entry name" value="GDS_CDC24_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22834">
        <property type="entry name" value="NUCLEAR FUSION PROTEIN FUS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22834:SF20">
        <property type="entry name" value="SH3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00741">
        <property type="entry name" value="DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="2">
        <location>
            <begin position="1062"/>
            <end position="1269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="614"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="829"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="927"/>
            <end position="1054"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1565"/>
            <end position="1702"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1719"/>
            <end position="1766"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="243"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="290"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="321"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="370"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="407"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="467"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="507"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="574"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="614"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="928"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="944"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="969"/>
            <end position="986"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1597"/>
            <end position="1608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1636"/>
            <end position="1645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1648"/>
            <end position="1661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1666"/>
            <end position="1692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1719"/>
            <end position="1740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1741"/>
            <end position="1753"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG00572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="1840" mass="202222" checksum="82DAD6DB0E2C6E11" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C1C6</accession>
    <name>A0A177C1C6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1167644</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441557">
        <property type="protein sequence ID" value="OAG01443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031808.1">
        <property type="nucleotide sequence ID" value="XM_018179225.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C1C6"/>
    <dbReference type="GeneID" id="28762711"/>
    <dbReference type="InParanoid" id="A0A177C1C6"/>
    <dbReference type="OrthoDB" id="10369355at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="28"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="247"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="288"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG01443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="298" mass="34689" checksum="4716416FC96A5C5B" modified="2016-09-07" version="1">MHRPMEPSPLRHSKDFLSPHGSTRTLGSVTSRRSQRSASTRHYGSHLSTIPSRSNISVFSPPFSPPLNPALHTRPLRLSSLHVLPHHPYPHGHYHQHSHITVGTVHSVQHYPRGPFKSGCPACGVDPVVLFPRHPWDQKHRQPWWEHLKEEYDFVKPYIEWQRRDKYLRTQRRRKEGKLLRQRFKLRTLKKTWKVELKRFGWKLLGWKNWEPDKERSRQRPQQQQQQPPEPTFNLLVTGGEDSNATQDDRDIQGHEARQELLGESEARTDGERADTSDAGNCLRGLAGKHESKSTSKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C1V5</accession>
    <name>A0A177C1V5_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">DNA-directed RNA polymerase subunit beta</fullName>
            <ecNumber evidence="14">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">CC84DRAFT_1198950</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23 24">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the RNA polymerase beta chain family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="14"/>
    <dbReference type="EMBL" id="KV441558">
        <property type="protein sequence ID" value="OAG00798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031163.1">
        <property type="nucleotide sequence ID" value="XM_018181595.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C1V5"/>
    <dbReference type="FunCoup" id="A0A177C1V5">
        <property type="interactions" value="1187"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177C1V5"/>
    <dbReference type="GeneID" id="28765081"/>
    <dbReference type="InParanoid" id="A0A177C1V5"/>
    <dbReference type="OrthoDB" id="10248617at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005721">
        <property type="term" value="C:pericentric heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032549">
        <property type="term" value="F:ribonucleoside binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003968">
        <property type="term" value="F:RNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140727">
        <property type="term" value="P:siRNA-mediated pericentric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00653">
        <property type="entry name" value="RNA_pol_B_RPB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.270.10:FF:000006">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.150:FF:000002">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1070.20:FF:000002">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1100.10:FF:000005">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1800.10:FF:000002">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1070.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1100.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.270.10">
        <property type="entry name" value="DNA-directed RNA polymerase, subunit 2, domain 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1800.10">
        <property type="entry name" value="RNA polymerase alpha subunit dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1110.10">
        <property type="entry name" value="RNA polymerase Rpb2, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015712">
        <property type="entry name" value="DNA-dir_RNA_pol_su2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007120">
        <property type="entry name" value="DNA-dir_RNAP_su2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037033">
        <property type="entry name" value="DNA-dir_RNAP_su2_hyb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007121">
        <property type="entry name" value="RNA_pol_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007644">
        <property type="entry name" value="RNA_pol_bsu_protrusion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007642">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037034">
        <property type="entry name" value="RNA_pol_Rpb2_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007645">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007646">
        <property type="entry name" value="RNA_pol_Rpb2_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007647">
        <property type="entry name" value="RNA_pol_Rpb2_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007641">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014724">
        <property type="entry name" value="RNA_pol_RPB2_OB-fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007175">
        <property type="entry name" value="PRK09606.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20856">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04563">
        <property type="entry name" value="RNA_pol_Rpb2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04561">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04565">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04566">
        <property type="entry name" value="RNA_pol_Rpb2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04567">
        <property type="entry name" value="RNA_pol_Rpb2_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00562">
        <property type="entry name" value="RNA_pol_Rpb2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04560">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01166">
        <property type="entry name" value="RNA_POL_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 14" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 14" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 14" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RNA polymerase beta subunit protrusion" evidence="19">
        <location>
            <begin position="38"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="18">
        <location>
            <begin position="284"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="20">
        <location>
            <begin position="495"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="21">
        <location>
            <begin position="594"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="22">
        <location>
            <begin position="699"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed RNA polymerase subunit 2 hybrid-binding" evidence="16">
        <location>
            <begin position="785"/>
            <end position="1158"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="17">
        <location>
            <begin position="1160"/>
            <end position="1252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="954"/>
            <end position="974"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU363031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF04560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF04561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF04563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF04565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF04566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF04567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="OAG00798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="1261" mass="142838" checksum="FB10D1C51D663578" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C269</accession>
    <name>A0A177C269_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Fumarate reductase flavo protein subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CC84DRAFT_1190194</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="KV441558">
        <property type="protein sequence ID" value="OAG00989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031354.1">
        <property type="nucleotide sequence ID" value="XM_018181103.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C269"/>
    <dbReference type="STRING" id="1460663.A0A177C269"/>
    <dbReference type="GeneID" id="28764589"/>
    <dbReference type="InParanoid" id="A0A177C269"/>
    <dbReference type="OrthoDB" id="7777654at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-dep_OxRdtase_2_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050315">
        <property type="entry name" value="FAD-oxidoreductase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006130">
        <property type="entry name" value="PRK08274.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43400:SF7">
        <property type="entry name" value="FAD-DEPENDENT OXIDOREDUCTASE 2 FAD BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43400">
        <property type="entry name" value="FUMARATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-dependent oxidoreductase 2 FAD-binding" evidence="5">
        <location>
            <begin position="11"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAG00989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="522" mass="56724" checksum="9185E5DC08E4F8FC" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C2D5</accession>
    <name>A0A177C2D5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1263082</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441558">
        <property type="protein sequence ID" value="OAG01022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031387.1">
        <property type="nucleotide sequence ID" value="XM_018185206.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C2D5"/>
    <dbReference type="GeneID" id="28768692"/>
    <dbReference type="InParanoid" id="A0A177C2D5"/>
    <dbReference type="OrthoDB" id="5229512at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038883">
        <property type="entry name" value="AN11006-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085:SF2">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="455"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="459"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="486"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG01022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="497" mass="56727" checksum="8AFE2CB53A73E978" modified="2016-09-07" version="1">MPDRTAGREGAGSLSFRFLDLPPELRDKIYQELLCDFKAAPSLGVNDVVEHKPCGYYVRTIHTAILRANQQIHLEAYDIMVKTNRFVHIKFFGGLPLDHMLETSTRRVICHHLPAVEAFKGYTMSVSVVPEGLAWWSPEDHHLVTRANSMAVHCMILGEDCAGLIRTLGNVHMPNLNKTLNISIAVAPYLQQNSPEQRELLEPFFKEPGTQEKLLAPFRAKLRGVEDIKIIGVDPSLASAIKEEIAKDEWTDSQTVLFEIQTAKQRGNDLFKAKELRAASQTWEEAVNDIERMHQSSSWKNLCVKGDTAFVDAMVELYFLMCLNITHVQLTGIDKPIPGYPRTHDAHVYLSLAEQQIDRVMNARQPNWWRKDYVWEPSDAQLAKLFFRQAMCRKADALLNGEPICMVDAIRTLELARQIVPDDAAIKREAESMEHEYERMLFEAERDVTPAQLFGEFGGDYEDEEDGFEDEDDFDDMPELLRHDESDEDFSDMPDTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C3J2</accession>
    <name>A0A177C3J2_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1100440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441557">
        <property type="protein sequence ID" value="OAG01469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031834.1">
        <property type="nucleotide sequence ID" value="XM_018174865.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C3J2"/>
    <dbReference type="STRING" id="1460663.A0A177C3J2"/>
    <dbReference type="GeneID" id="28758351"/>
    <dbReference type="InParanoid" id="A0A177C3J2"/>
    <dbReference type="OrthoDB" id="2157530at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF73">
        <property type="entry name" value="HET DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_8G01020)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="3"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG01469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="135" mass="15858" checksum="1EBC1270E05EBD91" modified="2016-09-07" version="1" fragment="single">MPNTIEINEHCLSITRNLSNALQYLFERNERRLWIDAICINQQNDVERGEQVGLMGRIYSWAKKVVVWLGHHADSSELAMDFLSLLASGPGDTDRLEWLLNLCEPEYSHHWKAVYTLLHRNWWKRAWVIQEAVLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C3X2</accession>
    <name>A0A177C3X2_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ASX DEUBAD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_203345</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441557">
        <property type="protein sequence ID" value="OAG01599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031964.1">
        <property type="nucleotide sequence ID" value="XM_018185584.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C3X2"/>
    <dbReference type="STRING" id="1460663.A0A177C3X2"/>
    <dbReference type="GeneID" id="28769070"/>
    <dbReference type="InParanoid" id="A0A177C3X2"/>
    <dbReference type="OrthoDB" id="2289918at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028020">
        <property type="entry name" value="ASX_DEUBAD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13919">
        <property type="entry name" value="ASXH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ASX DEUBAD" evidence="2">
        <location>
            <begin position="158"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="60"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="101"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG01599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="285" mass="30611" checksum="42FF3E2618E4E1C9" modified="2016-09-07" version="1">MSLPVRSPTVKEPSLEPPLPVDSSHDASTATIAPISSNQTQQSLKTTPISTEPVSASNGTGAPSPSGSVASSTSIESKKRAHAEVEDRQTTMTSAKRVKKAAASAGTKPARKGAPPAPRVGTRSSGRARKAPERFENLASPPKPATTTARKPGGRVFEPVYITTNANSRLKKIDLFHMLLKANAWTCLTSEQKLDILALLPLNPINVKLANDLRAGTAAEDARPREVSLNFNLFRTDVAKFKEDLSNGHLGKTWQASAEQAIKDRAAGAFDDWKEQEAELWWGQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C505</accession>
    <name>A0A177C505_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1153848</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441557">
        <property type="protein sequence ID" value="OAG01760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032125.1">
        <property type="nucleotide sequence ID" value="XM_018176856.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C505"/>
    <dbReference type="GeneID" id="28760342"/>
    <dbReference type="InParanoid" id="A0A177C505"/>
    <dbReference type="OrthoDB" id="3775566at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008057820" evidence="1">
        <location>
            <begin position="17"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG01760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="216" mass="23281" checksum="1DDAE67F51372C86" modified="2016-09-07" version="1">MTTLLALLTLVTSAVAQTATANFTGTGTISVWNSSDWTTATPASSLGCLSPKGKFIAPSSDAACGVFTRLDNYPYTLSTKEGNCTFSDETQERNTESIYGGTDHAWNCLEPYEANIYDDLYTIDGFPYVFLCSGDVDCYFDARLVPAPGSSDATSIWPFRWGSQQWGITPGHTMIQLVWNKMAAVQKRGDAVEPAGSRLSLEHGQAPALRGPKVLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C534</accession>
    <name>A0A177C534_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Pre-mRNA-splicing factor rse1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CC84DRAFT_1151919</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the RSE1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441556">
        <property type="protein sequence ID" value="OAG01878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032243.1">
        <property type="nucleotide sequence ID" value="XM_018176775.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C534"/>
    <dbReference type="FunCoup" id="A0A177C534">
        <property type="interactions" value="1284"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177C534"/>
    <dbReference type="GeneID" id="28760261"/>
    <dbReference type="InParanoid" id="A0A177C534"/>
    <dbReference type="OrthoDB" id="436637at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001143">
        <property type="entry name" value="Pre-mRNA-splicing factor rse-1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018846">
        <property type="entry name" value="Beta-prop_RSE1/DDB1/CPSF1_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058543">
        <property type="entry name" value="Beta-prop_RSE1/DDB1/CPSF1_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050358">
        <property type="entry name" value="RSE1/DDB1/CFT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004871">
        <property type="entry name" value="RSE1/DDB1/CPSF1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10644">
        <property type="entry name" value="DNA REPAIR/RNA PROCESSING CPSF FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10433">
        <property type="entry name" value="Beta-prop_RSE1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23726">
        <property type="entry name" value="Beta-prop_RSE1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03178">
        <property type="entry name" value="CPSF_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101908">
        <property type="entry name" value="Putative isomerase YbhE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="RSE1/DDB1/CPSF1 first beta-propeller" evidence="8">
        <location>
            <begin position="21"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="RSE1/DDB1/CPSF1 second beta-propeller" evidence="9">
        <location>
            <begin position="463"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="domain" description="RSE1/DDB1/CPSF1 C-terminal" evidence="7">
        <location>
            <begin position="882"/>
            <end position="1207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF10433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF23726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAG01878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1243" mass="137877" checksum="CB03A98F6F73821D" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C5E2</accession>
    <name>A0A177C5E2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1179288</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441556">
        <property type="protein sequence ID" value="OAG02371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032736.1">
        <property type="nucleotide sequence ID" value="XM_018180407.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C5E2"/>
    <dbReference type="GeneID" id="28763893"/>
    <dbReference type="InParanoid" id="A0A177C5E2"/>
    <dbReference type="OrthoDB" id="10675584at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="386"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="450"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="397"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="412"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG02371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="592" mass="63940" checksum="7CA37511C35EDAEA" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C5F1</accession>
    <name>A0A177C5F1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CC84DRAFT_975187</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441556">
        <property type="protein sequence ID" value="OAG01910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032275.1">
        <property type="nucleotide sequence ID" value="XM_018188023.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C5F1"/>
    <dbReference type="STRING" id="1460663.A0A177C5F1"/>
    <dbReference type="GeneID" id="28771509"/>
    <dbReference type="InParanoid" id="A0A177C5F1"/>
    <dbReference type="OrthoDB" id="3429912at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF17">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="233"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="7"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="94"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="143"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="94"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="143"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAG01910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="711" mass="78216" checksum="4B28BC634114738F" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C601</accession>
    <name>A0A177C601_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1003550</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441556">
        <property type="protein sequence ID" value="OAG02157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032522.1">
        <property type="nucleotide sequence ID" value="XM_018173335.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C601"/>
    <dbReference type="STRING" id="1460663.A0A177C601"/>
    <dbReference type="GeneID" id="28756821"/>
    <dbReference type="InParanoid" id="A0A177C601"/>
    <dbReference type="OrthoDB" id="2548233at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.30">
        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42034">
        <property type="entry name" value="CHROMOSOME 7, WHOLE GENOME SHOTGUN SEQUENCE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42034:SF1">
        <property type="entry name" value="CONDENSATION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG02157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="460" mass="51911" checksum="6197BFBE574FD0AA" modified="2016-09-07" version="1">MPLTWKETRPGRWERPQSCLEKVNLLNRNVDKALDRDNWAKTAVAKVEFDPKLGDPVQALKTAWKQVRYNYPEVAAFPYNGTYMYRIGNPEQIQLWVSATFVVEHNTTIDELFGHLPRNEQMMCYYLPDTSEILVRSPHYRLDARGAIFILNYLIKSLANPDPVLIFGGCAGNLSPSIDDALNIPFEYTPKIEEAATRRMASLNAHNPLIELTPNAKPNRAGATRRRFLKFSEAETKSITKGAKSAGMDYTAAMHAAVIAAVVRLAPPTEVQSYMASFHCDLRYLIPKSSKTKAAPIVCTDAITTEIEVSPSTNLKSYYNQLAPVYANGYAPYLESSACFHDKLAKEKYADGKGYESTDGQAQPRLGPLGIIDDQLTKHVKGVVRVKDFWLGGETLTKRKMVHNWIWEDQMTFSCCYNEKYWDDQFVELFLQTIKSVLMEEVAKTSSSSLSSKLKGMMLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2023-06-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C6M4</accession>
    <name>A0A177C6M4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1009945</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441556">
        <property type="protein sequence ID" value="OAG02350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032715.1">
        <property type="nucleotide sequence ID" value="XM_018173362.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C6M4"/>
    <dbReference type="GeneID" id="28756848"/>
    <dbReference type="InParanoid" id="A0A177C6M4"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG02350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="184" mass="19990" checksum="722F15D29924C365" modified="2016-09-07" version="1">MSSAYCVETQTSIFRRIRFFVFDELVHRLEEHTVLHPARVIGERRPLRYLVQPLRQSLAASGYIVEAGLALHLESLLNHSFNAGAANNIPAWCLKSLAQCCGVVFFDAVFASAGGSFGVEWEGAGEGLVGVAGEEIAEFEGEHNGCGLRCASREERAFGTGFGDARHKIDGFVCGEIQFGHDAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C851</accession>
    <name>A0A177C851_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1167020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG03311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033676.1">
        <property type="nucleotide sequence ID" value="XM_018179104.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C851"/>
    <dbReference type="GeneID" id="28762590"/>
    <dbReference type="InParanoid" id="A0A177C851"/>
    <dbReference type="OrthoDB" id="3539286at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051604">
        <property type="entry name" value="Ergot_Alk_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43162">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43162:SF1">
        <property type="entry name" value="PRESTALK A DIFFERENTIATION PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-binding" evidence="1">
        <location>
            <begin position="10"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG03311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="322" mass="35836" checksum="E51C02DD9B9923A1" modified="2016-09-07" version="1">MAPSYLITAANGHIGMRLIPLLLAHPSQPTLVLPTSNSARLTSSMPANVDRSRVHILEGSVQDPMFVEAAIKDHNVTAVFLCLTGPDELFTTFNFLDCIRRSGTVKHLVYVSAASDLSLEAQQSGLLKDIYCAHVAVKFIVEAKIMHGLLPREQNGGLSWTILGPTLFFSNDLSVQREMLEEGLFDEPLGSKGVSRVSEKDVALAAVKALEDDGKQWGGKKIMIGSLQTYTNQDTARLWSQALGRDISPTLSDKASLDEWEPRFAKKVGHAWGRDVRLMYEIFEEMPFGMTEEQYKEQVVLLGKEADSYEEFVETTSREWKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C8C9</accession>
    <name>A0A177C8C9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RmlC-like cupin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_872379</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG03893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034258.1">
        <property type="nucleotide sequence ID" value="XM_018187737.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C8C9"/>
    <dbReference type="STRING" id="1460663.A0A177C8C9"/>
    <dbReference type="GeneID" id="28771223"/>
    <dbReference type="InParanoid" id="A0A177C8C9"/>
    <dbReference type="OrthoDB" id="4124983at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053146">
        <property type="entry name" value="QDO-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36440">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_8G07350)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36440:SF1">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_8G07350)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin type-2" evidence="1">
        <location>
            <begin position="54"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG03893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="175" mass="19661" checksum="42AF124C86BC62D9" modified="2016-09-07" version="1">MDDEARQALAKMDMPRRPINFVPAQSGEILKLGHITCRVMEDGSRTDNRIGSAEFTVPAGTAGPPAHWHEMHDETFLVTQGTVRFHAPDNTIVDAKVGDYVTVPIRAPHTFSNPFDVEAKFFNTFTPAFYIDYFKILAEVSKSDEKMSKEKNLEVMARFATMPAKPLMDEVAKQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C8P4</accession>
    <name>A0A177C8P4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_963483</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG03219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033584.1">
        <property type="nucleotide sequence ID" value="XM_018187979.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C8P4"/>
    <dbReference type="GeneID" id="28771465"/>
    <dbReference type="InParanoid" id="A0A177C8P4"/>
    <dbReference type="OrthoDB" id="10422416at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG03219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="97" mass="11139" checksum="FFBF9F33618E95B9" modified="2016-09-07" version="1">MHSLAISHNADVSIDLSRVPCFDGARKSRRRKRRTTRQRTRQSGTNTKHLLKCHVAQSRRSWGRGTQLHRLDECAASRVRIWLGGRAARIRLLPLTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C8T5</accession>
    <name>A0A177C8T5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1165980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG03806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034171.1">
        <property type="nucleotide sequence ID" value="XM_018178843.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C8T5"/>
    <dbReference type="STRING" id="1460663.A0A177C8T5"/>
    <dbReference type="GeneID" id="28762329"/>
    <dbReference type="InParanoid" id="A0A177C8T5"/>
    <dbReference type="OrthoDB" id="5397628at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="77"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG03806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="343" mass="38163" checksum="FC36A43CBCA755DB" modified="2016-09-07" version="1">MGILLSTVQRTLNLLLPFTHPGTPLVQDLIHTAVLITTLYYAPQIADYYNAHYRPSSPHTPRNEGDTAPIDGQVDGPPADIPDAPLDDAWVLQDDGDNEDAGLEPPPLAPTPPPGQLHNPPPEDGVWQNDFAPGDPGPANDRPQATRANRVIGAKKAKSLARRDQRRAYHEFHRSQAEQRKLAEEAGREEREAALAQEKARRAEVEAQLAEEKRERLAWEREQKRKEAEEEHQRRERVVEKVREEIVRKGAVDLVDVAIEEGKDKVWVERLVRASGMLSQMEKGGAKVMITGEGWLVKIDAELMRTVYEEAASFGNSRDGKVSFANFGGILEKAVRARALAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C9E0</accession>
    <name>A0A177C9E0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_790620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG04364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034729.1">
        <property type="nucleotide sequence ID" value="XM_018187397.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C9E0"/>
    <dbReference type="GeneID" id="28770883"/>
    <dbReference type="InParanoid" id="A0A177C9E0"/>
    <dbReference type="OrthoDB" id="10623575at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG04364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="114" mass="12484" checksum="DBF5A0BC8F23E44A" modified="2016-09-07" version="1">MKAVTNRRTSRPNTTKRARNDSRSSAYRPLRGTSSRRSPHPQIHGTVSPAPKSRIKPSYCSSLDGASTIADSAHCVCELRGRTQHNHAILIGVKMPHRGCVDAVEGNVLARQML</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CAH9</accession>
    <name>A0A177CAH9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1218093</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG04663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035028.1">
        <property type="nucleotide sequence ID" value="XM_018182963.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CAH9"/>
    <dbReference type="GeneID" id="28766449"/>
    <dbReference type="InParanoid" id="A0A177CAH9"/>
    <dbReference type="OrthoDB" id="3798150at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG04663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="528" mass="59905" checksum="7AD8EF8820F48D20" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CAN3</accession>
    <name>A0A177CAN3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Vps54-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CC84DRAFT_1165107</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">trans-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VPS54 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG04723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035088.1">
        <property type="nucleotide sequence ID" value="XM_018178642.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CAN3"/>
    <dbReference type="FunCoup" id="A0A177CAN3">
        <property type="interactions" value="428"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CAN3"/>
    <dbReference type="GeneID" id="28762128"/>
    <dbReference type="InParanoid" id="A0A177CAN3"/>
    <dbReference type="OrthoDB" id="10259024at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000938">
        <property type="term" value="C:GARP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006896">
        <property type="term" value="P:Golgi to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039745">
        <property type="entry name" value="Vps54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012501">
        <property type="entry name" value="Vps54_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12965">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING 54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12965:SF0">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07928">
        <property type="entry name" value="Vps54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Vacuolar protein sorting-associated protein 54 C-terminal" evidence="8">
        <location>
            <begin position="834"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="178"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="255"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="556"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="801"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1083"/>
            <end position="1111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="188"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="562"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="807"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1084"/>
            <end position="1111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAG04723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="1111" mass="122262" checksum="0B4F9948D23594D7" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CAY2</accession>
    <name>A0A177CAY2_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF1996 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_1187767</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG04823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035188.1">
        <property type="nucleotide sequence ID" value="XM_018180955.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CAY2"/>
    <dbReference type="STRING" id="1460663.A0A177CAY2"/>
    <dbReference type="GeneID" id="28764441"/>
    <dbReference type="InParanoid" id="A0A177CAY2"/>
    <dbReference type="OrthoDB" id="74764at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018535">
        <property type="entry name" value="DUF1996"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43662">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43662:SF12">
        <property type="entry name" value="DUF1996 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09362">
        <property type="entry name" value="DUF1996"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008057915" description="DUF1996 domain-containing protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1996" evidence="3">
        <location>
            <begin position="35"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="274"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAG04823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="320" mass="34477" checksum="BE66673C5534CD01" modified="2016-09-07" version="1">MPSFTTFVGAAALAHMAAAYTQVNLRSAYMTKNIDPIVFPGSYDKSHLHSIFGSDALTASTTTSAELQKGCTNADNPNDLSAYWVPTPLFTTDGGKTYTPLGMFRFSAYYNLGETPAEVAIPQDLKMVAGKATATTEADMVANAQSSWGCEGESIPLDKNGFPSSTCATHIQQLLYFPNCVNVDTLETAYKDRRGGSCPSGMKSMPQLRFSIRWDARKNLPNGWSGEAPIKLACGNAFCSHGDFVNGWTEEAAQNMLATTQEKMHFSAVTGSLGTSQMSCTPKDAEPDKGTSDFAESVSLMSKRSVPEWGWASKSRLSRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2023-06-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CBD1</accession>
    <name>A0A177CBD1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_810534</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG04964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035329.1">
        <property type="nucleotide sequence ID" value="XM_018187517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CBD1"/>
    <dbReference type="GeneID" id="28771003"/>
    <dbReference type="InParanoid" id="A0A177CBD1"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG04964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="162" mass="17635" checksum="508C9243A6BB6E21" modified="2016-09-07" version="1">MLVRYFSGIVRSIWLQRQETLMRDCRKHTDAECPGTSITSNAGRRWCCGHCDRSGMVDCNSVRGLLTLNAGARSAQPKEVAPAQDLVTRSAPTRLPQNNLNAASYTSGSSCMSDHEPGSLSACSSVQFRHSLHCRRRSGWQNVDSLRGNSSCACGLISCTVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CBG7</accession>
    <name>A0A177CBG7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Carboxylic ester hydrolase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1165343</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG04994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035359.1">
        <property type="nucleotide sequence ID" value="XM_018178693.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CBG7"/>
    <dbReference type="GeneID" id="28762179"/>
    <dbReference type="InParanoid" id="A0A177CBG7"/>
    <dbReference type="OrthoDB" id="10007757at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008058053" description="Carboxylic ester hydrolase" evidence="1">
        <location>
            <begin position="18"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG04994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="175" mass="18124" checksum="AE416B1ABF49493A" modified="2016-09-07" version="1">MTVLWTLLPHTATIVTTNTIIATIPTCVSPTTSTVYGSISLCGAPAATYPSPTTGQITCTQPADAPSESVNAFHHIEADDTQGTAFEGCIFAGPSDSTTLSRGTHQCGTSTGVSLSSRKDAAARLIGFTYAGTYSPLFQDYFITRIASTAQTDIQSWGVLNNSVFTTLGGCGAQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CBK6</accession>
    <name>A0A177CBK6_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein SSH4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Protein ssh4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">CC84DRAFT_894954</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Components of the endosome-vacuole trafficking pathway that regulates nutrient transport. May be involved in processes which determine whether plasma membrane proteins are degraded or routed to the plasma membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endosome membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SSH4 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG04209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034574.1">
        <property type="nucleotide sequence ID" value="XM_018187812.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CBK6"/>
    <dbReference type="FunCoup" id="A0A177CBK6">
        <property type="interactions" value="35"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CBK6"/>
    <dbReference type="GeneID" id="28771298"/>
    <dbReference type="InParanoid" id="A0A177CBK6"/>
    <dbReference type="OrthoDB" id="258495at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12910">
        <property type="entry name" value="SPRY_SSH4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.920:FF:000065">
        <property type="entry name" value="Ear1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035780">
        <property type="entry name" value="SPRY_Ssh4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050618">
        <property type="entry name" value="Ubq-SigPath_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12864">
        <property type="entry name" value="RAN BINDING PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0967">Endosome</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="8 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <keyword evidence="7" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="62"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="B30.2/SPRY" evidence="18">
        <location>
            <begin position="129"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="376"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="442"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="383"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="456"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="480"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="524"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00025244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="OAG04209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="533" mass="58700" checksum="9067E54046A5564E" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CBK7</accession>
    <name>A0A177CBK7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Small nuclear ribonucleoprotein E</fullName>
            <shortName evidence="11">snRNP-E</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Sm protein E</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CC84DRAFT_1166263</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Involved in pre-mRNA splicing. Binds and is required for the stability of snRNA U1, U2, U4 and U5 which contain a highly conserved structural motif called the Sm binding site. Involved in cap modification.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG04157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034522.1">
        <property type="nucleotide sequence ID" value="XM_018178913.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CBK7"/>
    <dbReference type="FunCoup" id="A0A177CBK7">
        <property type="interactions" value="887"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CBK7"/>
    <dbReference type="GeneID" id="28762399"/>
    <dbReference type="InParanoid" id="A0A177CBK7"/>
    <dbReference type="OrthoDB" id="25620at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005687">
        <property type="term" value="C:U4 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990935">
        <property type="term" value="F:splicing factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036261">
        <property type="term" value="P:7-methylguanosine cap hypermethylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01718">
        <property type="entry name" value="Sm_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000031">
        <property type="entry name" value="Small nuclear ribonucleoprotein E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027078">
        <property type="entry name" value="snRNP-E"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11193">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 11" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8 11" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 11" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="7 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 11" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="12">
        <location>
            <begin position="17"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU365053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OAG04157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="95" mass="10783" checksum="1637C02E3D23A9CF" modified="2016-09-07" version="1">MTGGRGRGGQKVLLPPINFIFKLLQQRATVSIWLYENLGMRIEGKLRGFDEFMNLVIDDAVEVTLAKKETPEERRKLGQVLLKGDNISLIQQINN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CBR0</accession>
    <name>A0A177CBR0_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Histidine kinase HHK8p</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CC84DRAFT_896005</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG04259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034624.1">
        <property type="nucleotide sequence ID" value="XM_018187820.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CBR0"/>
    <dbReference type="STRING" id="1460663.A0A177CBR0"/>
    <dbReference type="GeneID" id="28771306"/>
    <dbReference type="InParanoid" id="A0A177CBR0"/>
    <dbReference type="OrthoDB" id="303614at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050956">
        <property type="entry name" value="2C_system_His_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058846">
        <property type="entry name" value="PAS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43719">
        <property type="entry name" value="TWO-COMPONENT HISTIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43719:SF30">
        <property type="entry name" value="TWO-COMPONENT SYSTEM RESPONSE REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26131">
        <property type="entry name" value="PAS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
        <property type="entry name" value="PAS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Histidine kinase" evidence="3">
        <location>
            <begin position="307"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="616"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="683"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAG04259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="796" mass="89371" checksum="B48185D54BE7D58F" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CBV8</accession>
    <name>A0A177CBV8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNase I-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_800297</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG04671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035036.1">
        <property type="nucleotide sequence ID" value="XM_018187461.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CBV8"/>
    <dbReference type="STRING" id="1460663.A0A177CBV8"/>
    <dbReference type="GeneID" id="28770947"/>
    <dbReference type="InParanoid" id="A0A177CBV8"/>
    <dbReference type="OrthoDB" id="2248459at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004439">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.10.10:FF:000036">
        <property type="entry name" value="Inositol polyphosphate phosphatase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046985">
        <property type="entry name" value="IP5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000300">
        <property type="entry name" value="IPPc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200">
        <property type="entry name" value="INOSITOL 5-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200:SF240">
        <property type="entry name" value="INOSITOL POLYPHOSPHATE 5-PHOSPHATASE C9G1.10C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22669">
        <property type="entry name" value="Exo_endo_phos2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00128">
        <property type="entry name" value="IPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Inositol polyphosphate-related phosphatase" evidence="2">
        <location>
            <begin position="814"/>
            <end position="1156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="250"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="263"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="336"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG04671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="1205" mass="134066" checksum="EC6B6E861CAA41BB" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CCL1</accession>
    <name>A0A177CCL1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_795499</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG04539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034904.1">
        <property type="nucleotide sequence ID" value="XM_018187438.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CCL1"/>
    <dbReference type="STRING" id="1460663.A0A177CCL1"/>
    <dbReference type="GeneID" id="28770924"/>
    <dbReference type="InParanoid" id="A0A177CCL1"/>
    <dbReference type="OrthoDB" id="3197614at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.80">
        <property type="entry name" value="Phosphotransferase system, lactose/cellobiose-type IIA subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40130">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40130:SF1">
        <property type="entry name" value="SPINDLE POLE BODY-ASSOCIATED PROTEIN CUT12 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="237"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="315"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="499"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="87"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="352"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="499"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="565"/>
            <end position="581"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG04539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="581" mass="62155" checksum="2E4928A7CE2685A5" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CCY7</accession>
    <name>A0A177CCY7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">E3 SUMO-protein ligase PIAS1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CC84DRAFT_1144908</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein sumoylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PIAS family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG05503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035868.1">
        <property type="nucleotide sequence ID" value="XM_018176480.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CCY7"/>
    <dbReference type="FunCoup" id="A0A177CCY7">
        <property type="interactions" value="206"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CCY7"/>
    <dbReference type="GeneID" id="28759966"/>
    <dbReference type="InParanoid" id="A0A177CCY7"/>
    <dbReference type="OrthoDB" id="28127at2759"/>
    <dbReference type="UniPathway" id="UPA00886"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061665">
        <property type="term" value="F:SUMO ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016925">
        <property type="term" value="P:protein sumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.780">
        <property type="entry name" value="PINIT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023321">
        <property type="entry name" value="PINIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038654">
        <property type="entry name" value="PINIT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003034">
        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004181">
        <property type="entry name" value="Znf_MIZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10782:SF4">
        <property type="entry name" value="TONALLI, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10782">
        <property type="entry name" value="ZINC FINGER MIZ DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14324">
        <property type="entry name" value="PINIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02891">
        <property type="entry name" value="zf-MIZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00513">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51466">
        <property type="entry name" value="PINIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50800">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51044">
        <property type="entry name" value="ZF_SP_RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SAP" evidence="10">
        <location>
            <begin position="17"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="domain" description="PINIT" evidence="12">
        <location>
            <begin position="107"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="SP-RING-type" evidence="11">
        <location>
            <begin position="295"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="77"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="381"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="435"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="91"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="381"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="411"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="455"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="537"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OAG05503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="560" mass="62415" checksum="05AD5DA176AAF17A" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CDM3</accession>
    <name>A0A177CDM3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1206435</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG04877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035242.1">
        <property type="nucleotide sequence ID" value="XM_018182029.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CDM3"/>
    <dbReference type="STRING" id="1460663.A0A177CDM3"/>
    <dbReference type="GeneID" id="28765515"/>
    <dbReference type="InParanoid" id="A0A177CDM3"/>
    <dbReference type="OrthoDB" id="3520662at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG04877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="279" mass="31425" checksum="FE0F19B3EB3F2945" modified="2016-09-07" version="1">MASCDTTSLLEQIEANILARDDTPFDEINEHLKKLQALADVYSTFVSTAHTLTDHAQDHILPQKLALRVKKMIKFTFGDPSRAADSDKVRSARLRKLDCNALKFCGLAYKVNEVCLLSELHFDLLLEKVTEFVCTRGLIEYLYRDDISKAVTTQLNLADEERDREYQKFLIANISSRPLKRSRATYDGSGTYSTTVVPNESPSKRQKTVTGSCLFESYLGSEVFVLTMHQVEEIIQSGRFGSDIRLIVPIYLETPPFITIPIANDVAIHHMTTRLAGTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CE69</accession>
    <name>A0A177CE69_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Histone H3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CC84DRAFT_1118920</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the histone H3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG05606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035971.1">
        <property type="nucleotide sequence ID" value="XM_018175537.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CE69"/>
    <dbReference type="STRING" id="1460663.A0A177CE69"/>
    <dbReference type="GeneID" id="28759023"/>
    <dbReference type="InParanoid" id="A0A177CE69"/>
    <dbReference type="OrthoDB" id="842664at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22911">
        <property type="entry name" value="HFD_H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000088">
        <property type="entry name" value="Histone H3-like centromeric protein CSE4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000164">
        <property type="entry name" value="Histone_H3/CENP-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45810">
        <property type="entry name" value="HISTONE H3.2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00622">
        <property type="entry name" value="HISTONEH3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00428">
        <property type="entry name" value="H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00959">
        <property type="entry name" value="HISTONE_H3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="6">
        <location>
            <begin position="61"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="12"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAG05606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="159" mass="17671" checksum="9BDF459DB6784D73" modified="2016-09-07" version="1">MPPKGQIRKNTARPSRPIGSSQRSARKQDTARKTGTPRRSSGGARVGDPGPAPKGKRRYKPGTVALKEIRKYQKSTELLLLKAPFQRLVREICQNVTTEDGPNRWQSQAVAALQEATEAFLVSLFHDANLCAIHAKRVTIQQKDIQLARRLRAAWGIPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CF07</accession>
    <name>A0A177CF07_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1218659</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG05300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035665.1">
        <property type="nucleotide sequence ID" value="XM_018183021.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CF07"/>
    <dbReference type="GeneID" id="28766507"/>
    <dbReference type="InParanoid" id="A0A177CF07"/>
    <dbReference type="OrthoDB" id="3794611at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="220"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="404"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="268"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="280"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="376"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="408"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="480"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG05300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="498" mass="54728" checksum="DE0216A54346A9B1" modified="2016-09-07" version="1">MPPRPKSKSKSATPTPSQGLRYPYTIRRIYLCGHPEEYVQIERAYHTRPPRILHTLVPQPQVVAGRSVGAYGQTRRQCTACASSLGQGSFSRSRDEVEWGRNRVKNRFLHVLMRERFSGQGERSIPWPKEKERGLGSEEYRGLQDIYEAIGTGRDVRPHSAVSYQDRVARKMVEGPAREGHAKVAYVLQTAVHAALAEGLGHGNFEDTELEREQLVEEKHELLSPKATNPRSLVSTNDKRAQSPKEGTGSNMRGSPSSPSAPAPISPRSPQRATPRSPTTNPPQPRRPPAPRQPRTSPEHTHRPVRPKLPADSQQEIAHHRALALAALEGRVPNVPTPGERHSDTTPTSAPRVPIPRPNPATVPSYISRQRPFGPTSASGGTTLSYGDGPRRYDGVPIAAVMETLYPENRDGKGEGRKDGEGVRLERGGYASFRSFESQRHPGPSAGSTRSRGSVGSAKSHGSGGRRRGDGESVRSFGSRKSDGRRGDARSPRRGWRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CF14</accession>
    <name>A0A177CF14_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1217461</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG06204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036569.1">
        <property type="nucleotide sequence ID" value="XM_018182894.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CF14"/>
    <dbReference type="GeneID" id="28766380"/>
    <dbReference type="InParanoid" id="A0A177CF14"/>
    <dbReference type="OrthoDB" id="648285at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG06204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="72" mass="8276" checksum="813102B88C5A1BF5" modified="2016-09-07" version="1">MTRANGQSAFIMVYNIVYGFIWAHFYYVKTAKHSLEEIAMAFGDRAFTDNDEDVVDTATAGKEKHEQLRKKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2023-06-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CFL6</accession>
    <name>A0A177CFL6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1175670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG05510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035875.1">
        <property type="nucleotide sequence ID" value="XM_018180170.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CFL6"/>
    <dbReference type="GeneID" id="28763656"/>
    <dbReference type="InParanoid" id="A0A177CFL6"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008058220" evidence="1">
        <location>
            <begin position="32"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG05510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="107" mass="11994" checksum="23E1F4A91FE81109" modified="2016-09-07" version="1">MAAAKGDARGPTWWMALWFQLKGSVPVMVRATPTMEACSTALQRELSWAFPAYGAQSEEYRDTGSMSYRRKFTFWGCARACCHSTDRECKEEIDPATRFVLSVAATP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CFQ6</accession>
    <name>A0A177CFQ6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cytochrome P450 monooxygenase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CC84DRAFT_1186957</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG05802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036167.1">
        <property type="nucleotide sequence ID" value="XM_018180894.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CFQ6"/>
    <dbReference type="STRING" id="1460663.A0A177CFQ6"/>
    <dbReference type="GeneID" id="28764380"/>
    <dbReference type="InParanoid" id="A0A177CFQ6"/>
    <dbReference type="OrthoDB" id="3945418at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11062">
        <property type="entry name" value="CYP58-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF157">
        <property type="entry name" value="N-ACETYLTRYPTOPHAN 6-HYDROXYLASE IVOC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7 8" id="KW-0408">Iron</keyword>
    <keyword evidence="3 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="447"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAG05802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="476" mass="53430" checksum="B677004D9F3B4489" modified="2016-09-07" version="1">MEGVWVTLLPAALATSAAYVVFIVLYNVYFHPLAAFPGPPVARTTIYWKAYVECILKRSFCDVLRELHAQYGDVVRVGPNELHFADPKAYHDIYNNKNRWDKESRLYKSFNEDRSSFGFLTYAEAKNRKDVLNRSFSQTAIESAESLLVEQTKALCEAFERQTKAGKSSNLLYAFRCMSMDVITSFCFGKPIYAVDAPGFQAPIVMAMDASLPVFVGFKYSDVFKNMILKCPPKLSKVVSPATAGLVDLQQLLLRQINDLTSDPEKLKALPHNMTIYHRLLDADAYRDKKLPSAGSLYEESQALMFGGADTVGNTLMVGAYYLLQNPDKQQTLRDELRTVWPSLDSAEADPRVKDLERLPYLNAVIKESLRLSSGVIWGLLRVVPTTGAKIAGVDIPPGTIVSTGSTFVHYNAAIFPEPDKFQPERWLESTDLDQWLVAFSRGPRMCLGINLAWAELRLGFSHVYRKFELATKIGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CGA3</accession>
    <name>A0A177CGA3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyl hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_732720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG05727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036092.1">
        <property type="nucleotide sequence ID" value="XM_018187215.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CGA3"/>
    <dbReference type="GeneID" id="28770701"/>
    <dbReference type="InParanoid" id="A0A177CGA3"/>
    <dbReference type="OrthoDB" id="3482285at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03143">
        <property type="entry name" value="A4_beta-galactosidase_middle_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029010">
        <property type="entry name" value="ThuA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40469:SF2">
        <property type="entry name" value="GALACTOSE-BINDING DOMAIN-LIKE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40469">
        <property type="entry name" value="SECRETED GLYCOSYL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06283">
        <property type="entry name" value="ThuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ThuA-like" evidence="1">
        <location>
            <begin position="9"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG05727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="231" mass="25810" checksum="F60485DA29BDF79D" modified="2016-09-07" version="1">METQKPFDVLVFSKTCGYRHDSIPAGVASLQCLAEQTSQFIVTASEDASTFTFDNLSNYAVIILLQTIGDIFTQDQLDALKQFVRDGGGVVAIHGAAAGMPNDAWYENLIGAHFDQHPPHEPGIVLVEDMNQDHFIMNCCGGRESWTDEFYNFTSHPRGNSNLKVLLRGDPKSFEGGKHGDDHPLAWCQEFEGGRVFFTALGHFDEAYSDEWFIEQMKRGILWAARKDNKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CGD5</accession>
    <name>A0A177CGD5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_1215697</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG06655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037020.1">
        <property type="nucleotide sequence ID" value="XM_018182738.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CGD5"/>
    <dbReference type="GeneID" id="28766224"/>
    <dbReference type="InParanoid" id="A0A177CGD5"/>
    <dbReference type="OrthoDB" id="2250022at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000057">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF84">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G09170)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="128"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="154"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="187"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="220"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="315"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="352"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="378"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="411"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="444"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="58"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAG06655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="485" mass="54004" checksum="1F5AC1E8BA2AF2F3" modified="2016-09-07" version="1">MASEPNTNQHELKPSASVEHIDELQKPHHDPAQLDRFGAATVKSPEEIALVKKLDLRMMPILWLMYFLNFLDRNAIVNGKLNNMHKDLHLVGTQYNTCVSIFFVGYLVGQVPSNMLLTRVKPSHYMAGWMMAWAIVSTLMVLVKGYTGMLVCRLVLGMTEAPFYPGALYVISSFYTRKETATRLSVFYTGNLLASSFSGLIAAGIFARLDGKHGLEGWRWLFLIQGVVTVFVAAASFFLLPNAPLQTRWLTQPERELAHSRIVLDTTELKGKVDVWKGLREACSDPRTWLFALMQNMHLSANGFKNFLPTVVQTLGFNTTITLVLTCPPYLISAFVSVAVSWSSGRFNERTWHVTLSKAVAIVGFIVGTATLNVGARYFAMVLFVGATYGVNNIVLAWTAGVLGQTHEKKAVALAIVNTLGNLSFVYTPYLWPDSDAPRFSKAMYASVGFSGGVVLCAWVMRLVLQRDNRKIRASDDEAINFYVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CH41</accession>
    <name>A0A177CH41_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1163182</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG06885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037250.1">
        <property type="nucleotide sequence ID" value="XM_018178200.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CH41"/>
    <dbReference type="GeneID" id="28761686"/>
    <dbReference type="InParanoid" id="A0A177CH41"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG06885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="58" mass="6441" checksum="96EDB696B662739A" modified="2016-09-07" version="1">MRVCIATLRLLPLGLWSARLFVSARCLLVAMVALLHQRTPPSLPHVLSHSPAKSQRNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CHW5</accession>
    <name>A0A177CHW5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_762249</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG06367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036732.1">
        <property type="nucleotide sequence ID" value="XM_018187340.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CHW5"/>
    <dbReference type="STRING" id="1460663.A0A177CHW5"/>
    <dbReference type="GeneID" id="28770826"/>
    <dbReference type="InParanoid" id="A0A177CHW5"/>
    <dbReference type="OrthoDB" id="2150604at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="115"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="187"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="220"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG06367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="251" mass="27834" checksum="1B906DC97C3FFD7D" modified="2016-09-07" version="1">MADAPLLGRGNDPSRSTGSRIKNARNVDTNTSIIRSILKIFSGGLIAPADTTYATIMILLNSTNAEEQDNLTTQWRDHKLNELSFIGVVSPLVAVCLVSTGAWDEISGKGWYIRAIWYSGIVFALFSVLTATQQTLRLHRLSAHKDGLHLLRLCLVRDRKPLDSEEGEAKLVPKPFQIWSWQSSMMFLMMAVGCLLVGMLVLVWSAVIKETKNVEYDENFKLAMSFTTVLAATVVYFFATQVSLMVGVSVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CI07</accession>
    <name>A0A177CI07_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Gibberellin 2-oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_1146697</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441552">
        <property type="protein sequence ID" value="OAG06508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036873.1">
        <property type="nucleotide sequence ID" value="XM_018176567.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CI07"/>
    <dbReference type="STRING" id="1460663.A0A177CI07"/>
    <dbReference type="GeneID" id="28760053"/>
    <dbReference type="InParanoid" id="A0A177CI07"/>
    <dbReference type="OrthoDB" id="406156at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.330:FF:000040">
        <property type="entry name" value="Chromosome 21, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050231">
        <property type="entry name" value="Iron_ascorbate_oxido_reductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47990">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00682">
        <property type="entry name" value="IPNSYNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Non-haem dioxygenase N-terminal" evidence="3">
        <location>
            <begin position="37"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="Isopenicillin N synthase-like Fe(2+) 2OG dioxygenase" evidence="2">
        <location>
            <begin position="210"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAG06508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="375" mass="43107" checksum="5C03B787DA5DF774" modified="2016-09-07" version="1">MAPGLVETASQTSQKLPIEKWVRPEPTKENLEWAPLSTIDLSRFDEPGGKQELAKQLYDAVTRVGFWVVTNTGIDDERVLRQFSIGNTFFKGSLEEKKRFPCNFAEGEYFGYRENSRWIGDTGVKENIEMLNIHKDIPAWKDVGKHRVTEENWEEIRTFHRDLWEKVARKLFVLISIMLELPENYLADAHAYDETSDDHLRYMIYNVRSQEEWDKAQAYSKGGHTDFGSLTLLFSQHVAGLQIRTPEGEWKYVKPVSGGITCNAADTLTFLTNGFVKSTIHRVVTPPSDQLKIPRLGLLYFSRPGDNTPMRTVPSPLLDRLGLIPEEHKDTSKPVPTGTEYVRARVRDVHHKTVLDKREGTKFQFKGLSVQNYYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CI78</accession>
    <name>A0A177CI78_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HET domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1241114</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG06559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018036924.1">
        <property type="nucleotide sequence ID" value="XM_018184044.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CI78"/>
    <dbReference type="STRING" id="1460663.A0A177CI78"/>
    <dbReference type="GeneID" id="28767530"/>
    <dbReference type="InParanoid" id="A0A177CI78"/>
    <dbReference type="OrthoDB" id="674604at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.270.20">
        <property type="entry name" value="Cytolysin/lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015926">
        <property type="entry name" value="Cytolysin/lectin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009960">
        <property type="entry name" value="Fruit_body_lectin_fun"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF10">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07367">
        <property type="entry name" value="FB_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63724">
        <property type="entry name" value="Cytolysin/lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="2">
        <location>
            <begin position="25"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="496"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="502"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG06559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="550" mass="62941" checksum="B5200C7EEA266D27" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CJL9</accession>
    <name>A0A177CJL9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mid2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CC84DRAFT_1163844</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG07734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038099.1">
        <property type="nucleotide sequence ID" value="XM_018178350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CJL9"/>
    <dbReference type="GeneID" id="28761836"/>
    <dbReference type="InParanoid" id="A0A177CJL9"/>
    <dbReference type="OrthoDB" id="5244543at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051694">
        <property type="entry name" value="Immunoregulatory_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549">
        <property type="entry name" value="PAIRED IMMUNOGLOBULIN-LIKE TYPE 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="112"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="81"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="186"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAG07734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="205" mass="21634" checksum="A65BD37CE46FCD48" modified="2016-09-07" version="1">MSSTITSLTRQTRTASRTSSATEAVCTWEGHCLGDTCSNENDCDNDWVCANTTCQTCCISKSEPTFFSTFSASDLTTITSPSSITTSATTPTSSSATSAPTNTSSGGLNTGAAVGIGIGGAALLIICIVGGWWFFMRRKNANQAYELGAVAPPSYDDDRKELYQATAQAQELPTRHPPVELHAIELAELEDSNTGRPNNEGKAMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CKJ1</accession>
    <name>A0A177CKJ1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CC84DRAFT_1117641</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441551">
        <property type="protein sequence ID" value="OAG07359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018037724.1">
        <property type="nucleotide sequence ID" value="XM_018175499.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CKJ1"/>
    <dbReference type="FunCoup" id="A0A177CKJ1">
        <property type="interactions" value="109"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CKJ1"/>
    <dbReference type="GeneID" id="28758985"/>
    <dbReference type="InParanoid" id="A0A177CKJ1"/>
    <dbReference type="OrthoDB" id="28208at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF458">
        <property type="entry name" value="SODIUM-COUPLED NEUTRAL AMINO ACID TRANSPORTER 11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="159"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="184"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="228"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="273"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="306"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="346"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="381"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="421"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="465"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="487"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="521"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="10">
        <location>
            <begin position="153"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="8"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="83"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OAG07359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="556" mass="60809" checksum="5BB6DEBA79AF02A9" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CL91</accession>
    <name>A0A177CL91_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CC84DRAFT_1162029</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038366.1">
        <property type="nucleotide sequence ID" value="XM_018177888.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CL91"/>
    <dbReference type="STRING" id="1460663.A0A177CL91"/>
    <dbReference type="GeneID" id="28761374"/>
    <dbReference type="InParanoid" id="A0A177CL91"/>
    <dbReference type="OrthoDB" id="419598at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051164">
        <property type="entry name" value="NmrA-like_oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748">
        <property type="entry name" value="NITROGEN METABOLITE REPRESSION PROTEIN NMRA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748:SF30">
        <property type="entry name" value="NMRA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="4">
        <location>
            <begin position="1"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAG08001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="319" mass="34744" checksum="42379D79E6FC89DC" modified="2016-09-07" version="1">MSKTALVIRATGSQGKGVVKHLAKSGWNVHAFVPDPSAERAVALKKFGDSVSLHKGSLDDAASVEAAIKGCNAVFLTQMPTWKDDSETREARMLLDAAKAAGVRHIAVSTQAGLSHPNVEQIFANPMIAPSVAGKIAVEKLVSECDIPWTALRPGWFNTNITLPVVDMMYPGLSDGKFINSYTPDLRICTVDPDDIGAFTAHVFDHPDQYAGRSVNIVSEEITVADIISEIERASGKTIDVHYRTEEENNKEAGNPFVIGQQLMKDLEGVADMDEVRSHGVPLTTFRQFLENNKDTVVPREGNHERLSADKLLSERVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CMJ5</accession>
    <name>A0A177CMJ5_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Saccharopine dehydrogenase-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1257529</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039098.1">
        <property type="nucleotide sequence ID" value="XM_018184740.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CMJ5"/>
    <dbReference type="STRING" id="1460663.A0A177CMJ5"/>
    <dbReference type="GeneID" id="28768226"/>
    <dbReference type="InParanoid" id="A0A177CMJ5"/>
    <dbReference type="OrthoDB" id="10059875at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032095">
        <property type="entry name" value="Sacchrp_dh-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16653">
        <property type="entry name" value="Sacchrp_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Saccharopine dehydrogenase-like C-terminal" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG08733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="64" mass="6889" checksum="E04202B2FC75AB37" modified="2016-09-07" version="1">MLQHKFVAEWQDGRKETSTPTLELLGDPEGYSAMALSVVAACGIATQLLLDEEPALRKPGVHAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CN36</accession>
    <name>A0A177CN36_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CC84DRAFT_1087312</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038594.1">
        <property type="nucleotide sequence ID" value="XM_018174197.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CN36"/>
    <dbReference type="STRING" id="1460663.A0A177CN36"/>
    <dbReference type="ESTHER" id="9pleo-a0a177cn36">
        <property type="family name" value="Fungal_carboxylesterase_lipase"/>
    </dbReference>
    <dbReference type="GeneID" id="28757683"/>
    <dbReference type="InParanoid" id="A0A177CN36"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050654">
        <property type="entry name" value="AChE-related_enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918">
        <property type="entry name" value="ACETYLCHOLINESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918:SF4">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007948964" description="Carboxylic ester hydrolase" evidence="3">
        <location>
            <begin position="18"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="28"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAG08229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="496" mass="54322" checksum="F653B643F60B1DCB" modified="2016-09-07" version="1">MRPFLLLSLSLPWIASGQYASYPQRYTRVKLPCGTLVNGLIDANFSSVRQFLGIPYAQPPVGDLRWEPPLAKRFSSPVNATAYGRSCTQPEVLTPNLENMDCPELSIQNKETGEDCLTLSLWTPTNATKLPVVIFFYGGGWYTGGQDVPYTIPTQWVQRTKDLIVVKPNSRGNIFGYPNAEGATNQNLGLLDQRLAVEWVRDNIEAFGGDSSKITIWGQSSGAEQVDYYNFAWHEDPIVQGLIMNSGTAFIEDGSGPKFSNFSYVATQVGCGNRTDAAAELSCMKKVNAATIEKVIADNLNGGGVPPLAFGSSADEKIVPSNLTKWALEGRIAKVPAIVGIDQNEGVGFVTYNADGPSAEDQALADYWFQALFLCPSFKTSKLRAAAGLPTYRYMYAGNFSNISPRPWMGAYHGSEQPMQFGTHGNYRGASTPYQIAVSEAMQDAYRAFIDDPLSGLKGQNWPTFTEEYGVVRWFASNGTVARNAIGELQAWEDKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CN86</accession>
    <name>A0A177CN86_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CC84DRAFT_1085540</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018038733.1">
        <property type="nucleotide sequence ID" value="XM_018174105.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CN86"/>
    <dbReference type="STRING" id="1460663.A0A177CN86"/>
    <dbReference type="GeneID" id="28757591"/>
    <dbReference type="InParanoid" id="A0A177CN86"/>
    <dbReference type="OrthoDB" id="3364175at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052783">
        <property type="entry name" value="Metabolic/Drug-Res_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47655">
        <property type="entry name" value="QUINIC ACID UTILIZATION ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47655:SF2">
        <property type="entry name" value="QUINIC ACID UTILIZATION ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="25"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="133"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="607"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="145"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAG08368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="744" mass="82411" checksum="A05045D6DA123DEF" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CNW5</accession>
    <name>A0A177CNW5_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Sequence orphan</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1202024</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG09225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039590.1">
        <property type="nucleotide sequence ID" value="XM_018181746.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CNW5"/>
    <dbReference type="GeneID" id="28765232"/>
    <dbReference type="InParanoid" id="A0A177CNW5"/>
    <dbReference type="OrthoDB" id="275936at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038781">
        <property type="entry name" value="C365.16-ike"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37845">
        <property type="entry name" value="SEQUENCE ORPHAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37845:SF1">
        <property type="entry name" value="SEQUENCE ORPHAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG09225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="307" mass="33663" checksum="BF42C316D98D367D" modified="2016-09-07" version="1">MTELVEKQSFNRGWRSYQLPGYLAGDVSAAFLSATLISPILTAIDRAVVENVSSTTRPLSIALKENILCTYRHPKRFFAAKPFFYMWTLYAVTYTTANSVNTLTTTFMDKSHEILAKSITFVVTCTVNVPLGVWKDIRFVQTFGGRPTPPPKGPVNTSPNSIKTSPPPQNPTKFPISVAATFLARDALTILGSFTLPPMLSHRIPIADPAAQMAAAQLLVPVLSQVVATPVHLLGLDLYSNPEKGERGQRVGRIRRGLLGTTAVRCARIVPAFGVGGIVNTGLREWFRGRVDGYGFPRRSDYNVHTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CPT9</accession>
    <name>A0A177CPT9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RNA polymerase Rpb4/RPC9 core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CC84DRAFT_1215361</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the eukaryotic RPB4 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039265.1">
        <property type="nucleotide sequence ID" value="XM_018182715.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CPT9"/>
    <dbReference type="STRING" id="1460663.A0A177CPT9"/>
    <dbReference type="GeneID" id="28766201"/>
    <dbReference type="InParanoid" id="A0A177CPT9"/>
    <dbReference type="OrthoDB" id="2186918at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010997">
        <property type="entry name" value="HRDC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006590">
        <property type="entry name" value="RNA_pol_Rpb4/RPC9_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045222">
        <property type="entry name" value="Rpb4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005574">
        <property type="entry name" value="Rpb4/RPC9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038324">
        <property type="entry name" value="Rpb4/RPC9_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21297">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03874">
        <property type="entry name" value="RNA_pol_Rpb4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00657">
        <property type="entry name" value="RPOL4c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47819">
        <property type="entry name" value="HRDC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNA polymerase Rpb4/RPC9 core" evidence="5">
        <location>
            <begin position="45"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAG08900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="174" mass="19305" checksum="9DF814FDCA5F74B7" modified="2016-09-07" version="1">MEDEPQDAPAHVAVEAPTFKAPRMVSRPKPQQQQEEEIGSELKLGDFEGEQPLSISEARAVVTAVHEKRKVKAAEGHGVLGDRTHNDSQSIQQFVDYLEMFARYKELNNLTAMGGVLDANPQFSMAERAMLGSLCCDTADEAKTLIPSLASKMDDESLQPVLDELQKYQDRLTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CPY6</accession>
    <name>A0A177CPY6_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Histone deacetylase interacting domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CC84DRAFT_1162658</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG08817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039182.1">
        <property type="nucleotide sequence ID" value="XM_018178052.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A177CPY6">
        <property type="interactions" value="1065"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CPY6"/>
    <dbReference type="GeneID" id="28761538"/>
    <dbReference type="InParanoid" id="A0A177CPY6"/>
    <dbReference type="OrthoDB" id="10265969at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033698">
        <property type="term" value="C:Rpd3L complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010628">
        <property type="term" value="P:positive regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1160.11:FF:000001">
        <property type="entry name" value="Paired amphipathic helix protein Sin3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1160.11:FF:000002">
        <property type="entry name" value="Paired amphipathic helix protein SIN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1160.11:FF:000003">
        <property type="entry name" value="Paired amphipathic helix SIN3-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1160.11">
        <property type="entry name" value="Paired amphipathic helix"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013194">
        <property type="entry name" value="HDAC_interact_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003822">
        <property type="entry name" value="PAH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036600">
        <property type="entry name" value="PAH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039774">
        <property type="entry name" value="Sin3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031693">
        <property type="entry name" value="Sin3_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12346:SF0">
        <property type="entry name" value="SIN3A, ISOFORM G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12346">
        <property type="entry name" value="SIN3B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02671">
        <property type="entry name" value="PAH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08295">
        <property type="entry name" value="Sin3_corepress"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16879">
        <property type="entry name" value="Sin3a_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00761">
        <property type="entry name" value="HDAC_interact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47762">
        <property type="entry name" value="PAH2 domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51477">
        <property type="entry name" value="PAH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Histone deacetylase interacting" evidence="9">
        <location>
            <begin position="849"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="401"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="444"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="648"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1137"/>
            <end position="1241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1578"/>
            <end position="1597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="18"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="44"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="75"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="93"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="129"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="151"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="171"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="182"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="482"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="694"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="709"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1137"/>
            <end position="1146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1166"/>
            <end position="1183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1184"/>
            <end position="1196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1221"/>
            <end position="1230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1231"/>
            <end position="1241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1578"/>
            <end position="1591"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAG08817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="1597" mass="178415" checksum="E7380024D6818D9F" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CQ96</accession>
    <name>A0A177CQ96_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_451051</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG09695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040060.1">
        <property type="nucleotide sequence ID" value="XM_018186316.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CQ96"/>
    <dbReference type="GeneID" id="28769802"/>
    <dbReference type="InParanoid" id="A0A177CQ96"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG09695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="157" mass="18760" checksum="918ED1204EAEA6F5" modified="2016-09-07" version="1">MKLTSRANALTTVIERPSHLNRKRERTHSRRRQCSHRLDPYNPQLALRLRRVHHNMDTVELQQGPQAPRLHMDNLIHRYRRLRMGKDKRKATGPKRSQYNIHTPSRRNSTTPMDRRPLRLHRAGERTQAKDNIHTIKDLHQVQTRLLAPQDHIVRQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CQE6</accession>
    <name>A0A177CQE6_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CC84DRAFT_1142349</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="KV441550">
        <property type="protein sequence ID" value="OAG09110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039475.1">
        <property type="nucleotide sequence ID" value="XM_018176365.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CQE6"/>
    <dbReference type="FunCoup" id="A0A177CQE6">
        <property type="interactions" value="799"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CQE6"/>
    <dbReference type="GeneID" id="28759851"/>
    <dbReference type="InParanoid" id="A0A177CQE6"/>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032889">
        <property type="term" value="P:regulation of vacuole fusion, non-autophagic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006624">
        <property type="term" value="P:vacuolar protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000550">
        <property type="entry name" value="Serine/threonine kinase 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000374">
        <property type="entry name" value="Serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052239">
        <property type="entry name" value="Ser/Thr-specific_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45998">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45998:SF2">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="34"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="163"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="172"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="203"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OAG09110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="406" mass="44666" checksum="86753B384CCB6E7A" modified="2016-09-07" version="1">MSLQSYFLDVIYSFTNCMVCFPGSPNLKINSRNFKILRLLGEGGFSYVYLVQDNANQQLFALKKIRCPFGQESVSQALKEVEAYSLFSPHPNIIHSIDYSVASDKSDPSAKTVYILLPYYRRGNLQDMINANLVNHTKFPEKRLMQLFLGVCKALKTMHQYRMSEGPGGARSEGKAKKVRKDAARADAEAAEAMEMRRHRDHDDDDEAEGEGLLESGEASLAQEGIAPGGERAYAHRDIKPGNVMIDDDGVNPILMDLGSLAPSPTPITSRSLALQVQDTAAEHSTMPYRAPELFDVKTGSVIDTKVDIWSMGCMLYACLVGKSPFEARSDETGGSLSMCVLGGDWRFPDEGRGAKKPADGEGISENVKEVVRKCLKVEPGERPDVDQLIEMVEGVIAELPEDGSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CQF8</accession>
    <name>A0A177CQF8_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1193119</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG09188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039553.1">
        <property type="nucleotide sequence ID" value="XM_018181275.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CQF8"/>
    <dbReference type="GeneID" id="28764761"/>
    <dbReference type="InParanoid" id="A0A177CQF8"/>
    <dbReference type="OrthoDB" id="2101473at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007396">
        <property type="entry name" value="TR_PAI2-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35802">
        <property type="entry name" value="PROTEASE SYNTHASE AND SPORULATION PROTEIN PAI 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35802:SF1">
        <property type="entry name" value="PROTEASE SYNTHASE AND SPORULATION PROTEIN PAI 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04299">
        <property type="entry name" value="FMN_bind_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG09188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="299" mass="33086" checksum="2A376040C2B038E4" modified="2016-09-07" version="1">MYLREIHAEKHIPTLYQFIKENPLGLLTTALDSNTFHSLQSSHIPWVLDNPDGEGTTELGTLRGHIARANPQAKSFIEAAKETRDGLTNADGSYTLTRDVLVIFNGPAHHYVTPKFYTGTKPATGKVVPTWNYSAVQVYGCATIFYETKADSTHTFLNKQIRDLTNHNEVETMGNKENPWAVEDAPESYIEILKKAIIGIQIEISDIGGKWKMSQESTVGDQEGVINGFAKLDTELGKEMSETVKASVHACLIADSDHPGSARNQTDSIAAPPLKFGLAWSVALRHQCDRPVFKLEHVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CQM9</accession>
    <name>A0A177CQM9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amidase signature enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_440465</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG09531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039896.1">
        <property type="nucleotide sequence ID" value="XM_018186288.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CQM9"/>
    <dbReference type="STRING" id="1460663.A0A177CQM9"/>
    <dbReference type="GeneID" id="28769774"/>
    <dbReference type="InParanoid" id="A0A177CQM9"/>
    <dbReference type="OrthoDB" id="566138at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42678">
        <property type="entry name" value="AMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42678:SF5">
        <property type="entry name" value="GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="1">
        <location>
            <begin position="37"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG09531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="545" mass="57450" checksum="A7FE8876ACCAF3A5" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CQZ7</accession>
    <name>A0A177CQZ7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glutathione transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CC84DRAFT_1136643</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG09199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039564.1">
        <property type="nucleotide sequence ID" value="XM_018176107.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CQZ7"/>
    <dbReference type="STRING" id="1460663.A0A177CQZ7"/>
    <dbReference type="GeneID" id="28759593"/>
    <dbReference type="InParanoid" id="A0A177CQZ7"/>
    <dbReference type="OrthoDB" id="2309723at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03190">
        <property type="entry name" value="GST_C_Omega_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00570">
        <property type="entry name" value="GST_N_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047047">
        <property type="entry name" value="GST_Omega-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016639">
        <property type="entry name" value="GST_Omega/GSH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32419:SF25">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32419">
        <property type="entry name" value="GLUTATHIONYL-HYDROQUINONE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13410">
        <property type="entry name" value="GST_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13409">
        <property type="entry name" value="GST_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015753">
        <property type="entry name" value="GST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01206">
        <property type="entry name" value="Xi.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01148">
        <property type="entry name" value="Xi_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST C-terminal" evidence="4">
        <location>
            <begin position="173"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="1">
        <location>
            <position position="196"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>glutathione</name>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="123"/>
            <end position="126"/>
        </location>
        <ligand>
            <name>glutathione</name>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="141"/>
            <end position="142"/>
        </location>
        <ligand>
            <name>glutathione</name>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Cys" evidence="3">
        <location>
            <position position="257"/>
        </location>
    </feature>
    <feature type="site" description="Lowers pKa of active site Cys" evidence="3">
        <location>
            <position position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR015753-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR015753-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR015753-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAG09199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="329" mass="37885" checksum="40B69964CFE71E3B" modified="2016-09-07" version="1">MTTTKLETQPSNPLPFCGDPPEANGLYQRFSRFRSFVPSKHFPAEKDRYVLYINYTCPWCHRAVIVHALKGLANVVQVVEVDGRDPTHGWFFGGARGPSRDPIHGFKWLREFYSMADPQYIGRITVPMLWDKKNRTVVNNESSEITRILIDGFDQFLPAERQEANKGASALIPSNLRNDIDQLNAWVYDNINNGVYKVGFATTQMAYNEHVVRLFQALDKLEQHLTQTNHQPFLFGNHITEADIRLYTTLIRFDVAYYTMFKCNLKMIRTDYPRLHHWLRTLYWSECPETGGGVFKRTTLFDVIKRGYSSITAGNGIVPIGPMPNIMLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CRI3</accession>
    <name>A0A177CRI3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Mitochondrial carnitine/acylcarnitine carrier protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CC84DRAFT_1255596</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG09578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039943.1">
        <property type="nucleotide sequence ID" value="XM_018184551.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CRI3"/>
    <dbReference type="GeneID" id="28768037"/>
    <dbReference type="InParanoid" id="A0A177CRI3"/>
    <dbReference type="OrthoDB" id="193856at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000064">
        <property type="term" value="F:L-ornithine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990575">
        <property type="term" value="P:mitochondrial L-ornithine transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050567">
        <property type="entry name" value="Mitochondrial_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624">
        <property type="entry name" value="MITOCHONDRIAL BASIC AMINO ACIDS TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624:SF57">
        <property type="entry name" value="MITOCHONDRIAL SUBSTRATE CARRIER FAMILY PROTEIN L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="25"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="129"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="226"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OAG09578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="317" mass="35552" checksum="D1074CFAEB59B2E8" modified="2016-09-07" version="1">MSAALKNQSKVPSELVDAPEQSKSPKNYRGFVGGVFSGIAKLSVGHPFDTIKVRMQTTDKSHFRGPVDCLMQTIRNEGVKGLYKGATPPLIGWMFMDSLMLGSLNVYRRVLNDNIFHPARYPGEQQKKLPVVGHAMAGVMAGWTVSFIAGPVEHIKARLQVQYAAEKSKRQYSGPIDCLKKTFNGHGIRGVWHGLSATLLFRTFFCFWWGSYEVFTQALNTNTNLSAPAVNFWAGGMSAQIFWLTSYPSDVIKQRVMTDPLGPERKFPRWRDAAKAVYREQGWKGYWRGFVPCFLRAFPANAMALVAFESVMRALPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CRU4</accession>
    <name>A0A177CRU4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">60S ribosomal export protein NMD3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CC84DRAFT_448938</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Acts as an adapter for the XPO1/CRM1-mediated export of the 60S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the NMD3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG09662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040027.1">
        <property type="nucleotide sequence ID" value="XM_018186307.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CRU4"/>
    <dbReference type="FunCoup" id="A0A177CRU4">
        <property type="interactions" value="1315"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CRU4"/>
    <dbReference type="GeneID" id="28769793"/>
    <dbReference type="InParanoid" id="A0A177CRU4"/>
    <dbReference type="OrthoDB" id="203821at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039768">
        <property type="entry name" value="Nmd3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007064">
        <property type="entry name" value="Nmd3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048899">
        <property type="entry name" value="NMD_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048898">
        <property type="entry name" value="OB_NMD3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12746:SF2">
        <property type="entry name" value="60S RIBOSOMAL EXPORT PROTEIN NMD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12746">
        <property type="entry name" value="NONSENSE-MEDIATED MRNA DECAY PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04981">
        <property type="entry name" value="NMD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21193">
        <property type="entry name" value="NMD_SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21192">
        <property type="entry name" value="OB_NMD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nmd3 N-terminal" evidence="9">
        <location>
            <begin position="21"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="60S ribosomal export protein NMD3 SH3" evidence="11">
        <location>
            <begin position="254"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="60S ribosomal export protein NMD3 OB-fold" evidence="10">
        <location>
            <begin position="318"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="461"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="474"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF21192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF21193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OAG09662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="510" mass="57948" checksum="91DDAE4868924540" modified="2016-09-07" version="1">MEIDAPLSFTPGAKSAATVLCADCGAPIDGTQSAGAFCYDCIKLKTDVTGGIQREATLHMCRDCDRWLSPPNSWVVARPESRELLALCLKKLRGLHKLRIIDASFIWTEPHSRRIKVKITVQSELGDGAIMQQTFEVEYTQNYHQCPDCQKSYTHNTWRACVQVRQKVPHKRTFLYLEQAILKHGAHKDAINIKEMHDGIDFFFAQRNHAEGFVDFLKAVVPANVKKSQELISHDIHTSTKSYKFSYSAEIVPICKDDLVVLPIPLARKIGNISPLTLCNRIGTSINLIDPATLQTAEVDTAVYWRTPFRSLADVQELVEFVVLDIEPLGQSRGRHFLAEATVSRASDMGSNDSTYYTRTHLGGILHVGDSVMGYHMTGTNFNNELFDKLEESKLSSTIPDVTRSQKAKSKRNWRIKRMAREESEMLPRKQDQEKMERDFELFLRDVEEDPEFRAGIQLYKQQQEAQAQKDADAMEVEESDVEEEDHGLAIPMEQLLDDFEDMTMAEDKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CRW9</accession>
    <name>A0A177CRW9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_439352</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG09509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018039874.1">
        <property type="nucleotide sequence ID" value="XM_018186282.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CRW9"/>
    <dbReference type="GeneID" id="28769768"/>
    <dbReference type="InParanoid" id="A0A177CRW9"/>
    <dbReference type="OrthoDB" id="5426563at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG09509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="500" mass="54229" checksum="FCCA15BCA99C0B2A" modified="2016-09-07" version="1">MSFKGRRQQSNSLDANDTEENLLDTKRRRLLRQSDWAGLTRPKLLMLNFQAQRGRDEIGKRRKTSHHNALTMHEDPSRLVPLPEAGTRRQLGGGARQHHDIKVRIGSDALTNRTTVHTSPQAQASATWDEVSSEEMTSGNAALHRAAPKPGQQADPNARRFVGAPTHALHPRNSTWGVMPRNQQLHYVGGSAGSMRVGLNEDSNASPNDQSVVSSSAEDHVSANKRGEVSNYCITQQVEGTTRSLRLTFDAATEFSAMAPIENASSCNLIGESNHNHYTANAAVTESGHVQMEAGAAGNAEPRPPHDIDEGPWMTFLPVQANSSSLSVADDLSALNRAHDRPAIHPLSNSASWSQRATQGARALADASLCVSPCLPSITQKCEKDELREHVHAGPGRSERSEKHIDGNDEFWQRLVFGSDKLDSTDGRPEATSPDKVIMDERRIVPFVAVSRSSTPFDPLHGPGFCVSDSTQAAATRAPLVTSSGSMLPIITSSTAPRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CSP6</accession>
    <name>A0A177CSP6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1256374</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018040918.1">
        <property type="nucleotide sequence ID" value="XM_018184618.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CSP6"/>
    <dbReference type="GeneID" id="28768104"/>
    <dbReference type="InParanoid" id="A0A177CSP6"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG10553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="198" mass="21640" checksum="96FAD4A234AA6285" modified="2016-09-07" version="1">MAPRQSGSPKPAATKQSTGVTKLKSSSNNGCGPRAQRQRRHGHAIVPSPSVIEEEQKPNLSAGSDDDTESVLSPLDDFSPVGDELHVPEKRDGVSAWTIVPTYQAKKSMSPTPKPHTPLAEGVPGTEDLITRVPGQKAVAVVTPNEKHSKNNMANWRSLDLVQDRPRIDEEAESSEDEWLDKYNKKSVVAKPKRKDHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CTQ1</accession>
    <name>A0A177CTQ1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Class I glutamine amidotransferase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1082426</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041279.1">
        <property type="nucleotide sequence ID" value="XM_018173982.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CTQ1"/>
    <dbReference type="STRING" id="1460663.A0A177CTQ1"/>
    <dbReference type="GeneID" id="28757468"/>
    <dbReference type="InParanoid" id="A0A177CTQ1"/>
    <dbReference type="OrthoDB" id="543156at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03139">
        <property type="entry name" value="GATase1_PfpI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052158">
        <property type="entry name" value="INH-QAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43130">
        <property type="entry name" value="ARAC-FAMILY TRANSCRIPTIONAL REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43130:SF15">
        <property type="entry name" value="THIJ_PFPI FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_5G14240)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008058656" evidence="1">
        <location>
            <begin position="20"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="DJ-1/PfpI" evidence="2">
        <location>
            <begin position="133"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG10914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="278" mass="29740" checksum="616E4CD715A1E319" modified="2016-09-07" version="1">MRKTFYTSLLAAVPMTALAQERPGLANSSAVPTHYGILLTPSITPIDMFGPMDVFQGLAMGFQNLTGPMHLSIISVNSTPSTTNPPMPGIDFGMALPPTITIAEYLAAAANNFTSIDESTTNSTCHTSTKIPGPLDVLLVPGGGGTRKDVSHEVDFVRTVYPSLKHLISVCTGSTIIARAGVLDGRKATTNKKAWAWATSFGNNVSYVPHARWVQDGNVWTSSGVSAGVDVSYAFLSSVYGEEVSQWVADVSEYTRWTNASYDPFADRWGPLNTTALK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CUT5</accession>
    <name>A0A177CUT5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1253780</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG11283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041648.1">
        <property type="nucleotide sequence ID" value="XM_018184403.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CUT5"/>
    <dbReference type="STRING" id="1460663.A0A177CUT5"/>
    <dbReference type="GeneID" id="28767889"/>
    <dbReference type="InParanoid" id="A0A177CUT5"/>
    <dbReference type="OrthoDB" id="3796487at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="247"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="327"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="333"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="370"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG11283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="588" mass="62777" checksum="45AD824DEB60F0E3" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CV56</accession>
    <name>A0A177CV56_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1073601</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041147.1">
        <property type="nucleotide sequence ID" value="XM_018173689.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CV56"/>
    <dbReference type="GeneID" id="28757175"/>
    <dbReference type="InParanoid" id="A0A177CV56"/>
    <dbReference type="OrthoDB" id="2832510at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052523">
        <property type="entry name" value="Trichothecene_AcTrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791">
        <property type="entry name" value="GNAT FAMILY ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791:SF14">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13673">
        <property type="entry name" value="Acetyltransf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG10782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="68" mass="7504" checksum="56A07E3267A021E0" modified="2016-09-07" version="1" fragment="single">WVLMHMVTHPAHRGKGAAGILVKWGIEQAERDGVPAYLEAGVMGRPIYERYGFIQVGELLEVDLKEGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CVE6</accession>
    <name>A0A177CVE6_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1159027</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG11503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041868.1">
        <property type="nucleotide sequence ID" value="XM_018177118.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CVE6"/>
    <dbReference type="GeneID" id="28760604"/>
    <dbReference type="InParanoid" id="A0A177CVE6"/>
    <dbReference type="OrthoDB" id="10430794at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG11503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="78" mass="8521" checksum="3C162D7D9FD4D488" modified="2016-09-07" version="1">MRQIASIAQPALLGCASQVLGGEHDLCRLLTNCMAARELEKALLCLTQPLMVMVTNRPRSLGCGWPAVRVLDFRQGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CVI7</accession>
    <name>A0A177CVI7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CC84DRAFT_1200798</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG11543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041908.1">
        <property type="nucleotide sequence ID" value="XM_018181686.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CVI7"/>
    <dbReference type="GeneID" id="28765172"/>
    <dbReference type="InParanoid" id="A0A177CVI7"/>
    <dbReference type="OrthoDB" id="10261408at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF3">
        <property type="entry name" value="HALOTOLERANCE PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="31"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAG11543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="290" mass="31959" checksum="0BFEBC4A2627D4A3" modified="2016-09-07" version="1">MNRAPPSPEYRDGPTQMASKDAGKGVRITLACNACRSRKHRCSGEKPQCAQCASNNVTCTWPAQQKRGPPKHYINSLEVRLLETEAVLLSLLSQVSTEQLKASFESLPPTGRTYNDPNCQPEQNTVYFSEFKQDVCKPSYWSSFPLDSDENVRRWWEDRMSRVRPGQLEADFVPGMPLHESLESEARQGGLPGLGVSLPVDSGLLQHTGYAEQAGLNSTGTEMNGPVTTLNQSTSRHGPNVDMHPGASMMRNEDAISTTTSEVSETLLSPDTGSGALIQIPDEFKQEFLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CVP7</accession>
    <name>A0A177CVP7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">DUF1640-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CC84DRAFT_1073092</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441549">
        <property type="protein sequence ID" value="OAG10940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041305.1">
        <property type="nucleotide sequence ID" value="XM_018173684.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CVP7"/>
    <dbReference type="STRING" id="1460663.A0A177CVP7"/>
    <dbReference type="GeneID" id="28757170"/>
    <dbReference type="InParanoid" id="A0A177CVP7"/>
    <dbReference type="OrthoDB" id="5424147at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024461">
        <property type="entry name" value="CCDC90-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14360:SF12">
        <property type="entry name" value="MOZ PROTEIN REPRESENTS A CHROMATIN-ASSOCIATED ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14360">
        <property type="entry name" value="PROTEIN FMP32, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07798">
        <property type="entry name" value="CCDC90-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="16"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="343"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="60"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="84"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="115"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAG10940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="383" mass="43178" checksum="F50DEF13C1405B87" modified="2016-09-07" version="1" fragment="single">MATPRLPFLWPVLFKPLKAPRTRAPNVTRCTPSRRRLAATSRPRQEVITQRYGTAQEPAPHLRDHETQKGSEKEAEASSQPEPEPVEEEEDEGPLPPTMPSTQMKSADADLPDEATPPPPLEPPKPPDAKPLDTVLHMPSPQEEEERKPPHLKTPPYVHHFDTYSLVKDLTKSGFTEDQSVSIMKAVRGILTDNMELAREGLVSKSNVENETYLFRAACSELRTEVGNTRKAEVERMRSERNQLQHEVDILSQRMGQETSHLKDELKGLFDDRKMAVRNEQRHMESLIQRLGYKITVELNSDARSEVEGLRWILTRRAATAIGISAFLLFTCLRFMSYSSHLTQEQKKKDEAPPEPSDNSPATGKPMLGKDEPLGGELLTTEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CVP8</accession>
    <name>A0A177CVP8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1211298</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG11644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042009.1">
        <property type="nucleotide sequence ID" value="XM_018182366.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CVP8"/>
    <dbReference type="GeneID" id="28765852"/>
    <dbReference type="InParanoid" id="A0A177CVP8"/>
    <dbReference type="OrthoDB" id="10503517at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="133"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="166"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG11644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="195" mass="21212" checksum="67C09B4B542D6912" modified="2016-09-07" version="1">MATKERLSAEALKASKIMTNMMAEFKTFRGILLGIQKAERDHNTQGQRDLLHRLTDQIGSTDDDEANFKTMDEANAKIRELKANEKEISAMLKQSQIDREELEGRLSTHQAEVDRSMNERDFTGDVKKLTGVASAAGASWSSGRPANARTSTDDGGAVGPRSIRLSKQSSSDVVPSSSHSSPASPMDDSDDGDLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2023-09-13" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CW66</accession>
    <name>A0A177CW66_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_53409</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG11795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042160.1">
        <property type="nucleotide sequence ID" value="XM_018186649.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CW66"/>
    <dbReference type="GeneID" id="28770135"/>
    <dbReference type="InParanoid" id="A0A177CW66"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008058668" description="Secreted protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG11795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="135" mass="15527" checksum="1B71A4CAFB32FC8C" modified="2016-09-07" version="1">MKLLQLVWVCVGLPQIVRLALDKRRKAISSLVGRRFLRVSLADNGTCSKRHFLACKQRCGRVRCWRVLSSLALALVSAEQSWAPARRQQTRSARVPRNGRAPIRQRALLLCEFWGRAKSPNTERPMECVWDRFGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CWT0</accession>
    <name>A0A177CWT0_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Trehalose-6-phosphate synthase</fullName>
            <ecNumber evidence="6">2.4.1.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">UDP-glucose-glucosephosphate glucosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_1079441</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>D-glucose 6-phosphate + UDP-alpha-D-glucose = alpha,alpha-trehalose 6-phosphate + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18889"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58429"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:61548"/>
            <dbReference type="EC" id="2.4.1.15"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Carbohydrate biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the glycosyltransferase 20 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.15" evidence="6"/>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG11362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041727.1">
        <property type="nucleotide sequence ID" value="XM_018173850.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CWT0"/>
    <dbReference type="FunCoup" id="A0A177CWT0">
        <property type="interactions" value="571"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CWT0"/>
    <dbReference type="GeneID" id="28757336"/>
    <dbReference type="InParanoid" id="A0A177CWT0"/>
    <dbReference type="OrthoDB" id="755951at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005946">
        <property type="term" value="C:alpha,alpha-trehalose-phosphate synthase complex (UDP-forming)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003825">
        <property type="term" value="F:alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004805">
        <property type="term" value="F:trehalose-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034605">
        <property type="term" value="P:cellular response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005992">
        <property type="term" value="P:trehalose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd03788">
        <property type="entry name" value="GT20_TPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000007">
        <property type="entry name" value="Trehalose-6-phosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000035">
        <property type="entry name" value="Trehalose-6-phosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001830">
        <property type="entry name" value="Glyco_trans_20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012766">
        <property type="entry name" value="Trehalose_OtsA"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02400">
        <property type="entry name" value="trehalose_OtsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10788:SF106">
        <property type="entry name" value="BCDNA.GH08860"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10788">
        <property type="entry name" value="TREHALOSE-6-PHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00982">
        <property type="entry name" value="Glyco_transf_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 8" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="491"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAG11362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="539" mass="60802" checksum="1D3948D54CDC2EF5" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CWZ3</accession>
    <name>A0A177CWZ3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">chitinase</fullName>
            <ecNumber evidence="3">3.2.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CC84DRAFT_1080353</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Dual chitinase/transglycosylase that plays a role in cell wall architecture. Chitinase and transglycosylase activities are coupled. Required for the polysaccharide cross-linking at the septa and the cell wall. More specifically, transfers chitin to 1,6-beta-glucan in the cell wall.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the glycosyl hydrolase 16 family. CRH1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.14" evidence="3"/>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG11380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041745.1">
        <property type="nucleotide sequence ID" value="XM_018173891.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CWZ3"/>
    <dbReference type="FunCoup" id="A0A177CWZ3">
        <property type="interactions" value="22"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CWZ3"/>
    <dbReference type="GeneID" id="28757377"/>
    <dbReference type="InParanoid" id="A0A177CWZ3"/>
    <dbReference type="OrthoDB" id="4781at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02183">
        <property type="entry name" value="GH16_fungal_CRH1_transglycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000152">
        <property type="entry name" value="Cell wall glucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF68">
        <property type="entry name" value="GLYCOSIDASE CRH1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00722">
        <property type="entry name" value="Glyco_hydro_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008058691" description="chitinase" evidence="14">
        <location>
            <begin position="21"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="15">
        <location>
            <begin position="28"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00038074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00093308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OAG11380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="363" mass="38680" checksum="D311276AF41AD2EC" modified="2016-09-07" version="1">MLRTLRAVAACALLSAPALAQTYTNCNPTESTSCPPDSALGKTVNIDFTSASDSFTAEGNPTYGSDGASFTVAKQGDSPKVTSKWYIMFGQVDIELQAAPGQGIVSSFFLQSDCLDEIDWEWLGGDNAQVQSNYFGKGNTATHDRGAFHANPGNHDGFQKYTIIWTSEQIAWQINGQTVRTLIPENANGQYPQTPMAIKIGAWAGGDPNNEQGTIDWAGGLTDYSKGPYTMKVKNLKVQDYSTGTTYTYGDTSGTWQSIKSNGGTINGGGTRVEQNAPGITSAATGAPLPFTPHTTSPYTRPSVYPWVPDTTVATVATTTYGNYPGLPSGWSVSDSGKVVPPSQAPVSKHLFLPLPPLHIHSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CX20</accession>
    <name>A0A177CX20_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Complex I intermediate-associated protein-like protein 84</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1253914</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG11452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041817.1">
        <property type="nucleotide sequence ID" value="XM_018184413.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CX20"/>
    <dbReference type="STRING" id="1460663.A0A177CX20"/>
    <dbReference type="GeneID" id="28767899"/>
    <dbReference type="InParanoid" id="A0A177CX20"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050667">
        <property type="entry name" value="PPR-containing_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47939">
        <property type="entry name" value="MEMBRANE-ASSOCIATED SALT-INDUCIBLE PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47939:SF1">
        <property type="entry name" value="OS04G0684500 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG11452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="806" mass="91198" checksum="57F082996B7E1F1F" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CXM6</accession>
    <name>A0A177CXM6_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">lytic cellulose monooxygenase (C4-dehydrogenating)</fullName>
            <ecNumber evidence="15">1.14.99.56</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">CC84DRAFT_1068713</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>[(1-&gt;4)-beta-D-glucosyl]n+m + reduced acceptor + O2 = 4-dehydro-beta-D-glucosyl-[(1-&gt;4)-beta-D-glucosyl]n-1 + [(1-&gt;4)-beta-D-glucosyl]m + acceptor + H2O.</text>
            <dbReference type="EC" id="1.14.99.56"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the polysaccharide monooxygenase AA9 family.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.56" evidence="15"/>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG11469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041834.1">
        <property type="nucleotide sequence ID" value="XM_018173650.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CXM6"/>
    <dbReference type="GeneID" id="28757136"/>
    <dbReference type="InParanoid" id="A0A177CXM6"/>
    <dbReference type="OrthoDB" id="6038816at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049892">
        <property type="entry name" value="AA9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005103">
        <property type="entry name" value="AA9_LPMO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353:SF10">
        <property type="entry name" value="ENDO-BETA-1,4-GLUCANASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03443">
        <property type="entry name" value="AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="8" id="KW-0186">Copper</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 16" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008058721" description="lytic cellulose monooxygenase (C4-dehydrogenating)" evidence="16">
        <location>
            <begin position="20"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="Auxiliary Activity family 9 catalytic" evidence="17">
        <location>
            <begin position="20"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="18">
        <location>
            <position position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00045077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF03443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="OAG11469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="147" mass="16034" checksum="3FFDE4D8D5F50937" modified="2016-09-07" version="1" fragment="single">MKTLLLPLATALLAQQGNAHYVFNRLIVNNTVSKEFQYIRDVTGNAGTRESTWLKSFPIFGPENENVTCGRGAFPVSNAATIETATIVAGSKVGFMVSPPMFDDDLIQYIYHEGPGQMFLSKLPEGTESLNDYDASGDFFKIGYAGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CXN9</accession>
    <name>A0A177CXN9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Snare complex subunit protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CC84DRAFT_1159088</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Endomembrane system</location>
            <topology evidence="8">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG11597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018041962.1">
        <property type="nucleotide sequence ID" value="XM_018177135.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CXN9"/>
    <dbReference type="FunCoup" id="A0A177CXN9">
        <property type="interactions" value="83"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CXN9"/>
    <dbReference type="GeneID" id="28760621"/>
    <dbReference type="InParanoid" id="A0A177CXN9"/>
    <dbReference type="OrthoDB" id="3063237at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000138">
        <property type="term" value="C:Golgi trans cisterna"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd15853">
        <property type="entry name" value="SNARE_Bet1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039899">
        <property type="entry name" value="BET1_SNARE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12791">
        <property type="entry name" value="GOLGI SNARE BET1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAG11597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="98" mass="10820" checksum="A1C693E2D66007C0" modified="2016-09-07" version="1">MSSQAWEREQQNDRLLDELSSKVTALRGVTIDIYDNARDHTLIESTSDTFSSLGTTIKGSAGRLTRMAQSGNKVAVLKLAGIIIGVCLVLYWGFRLIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CXW2</accession>
    <name>A0A177CXW2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1201147</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042406.1">
        <property type="nucleotide sequence ID" value="XM_018181708.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CXW2"/>
    <dbReference type="GeneID" id="28765194"/>
    <dbReference type="InParanoid" id="A0A177CXW2"/>
    <dbReference type="OrthoDB" id="3777131at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG12041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="348" mass="38571" checksum="1503CB24F39BA8A0" modified="2016-09-07" version="1">MDDKLQYSTDTLLPGREADIEGQLHFSLNNAAAWGRAEDSIQLGHMKEEDGWPAYLSMPSNGPLPAPAGLDAGREVLHPEALAPPHKRSAISGLDTDDRTDTRSENATNCRIAPDINGELQEDTPLPSTEQANVELRDAKQVLAERAAERERRKRERATQVLPPRKRARKALKASSSVDLDSVEQHHMPTEILSTNSLAAPWPALSPSHATNTSEPLLSLDELRVISNLMAAQSMSVDLTTTYTSARLNSMTESIWTALCKDALSEFSLKVHGAQLWTHIGEEVIAWPEEWLRVLASMEVLPTWWWVREGLVDLVVLEGAKVDDGEMDMVWNEHAERVAQRKGSAERG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CXX5</accession>
    <name>A0A177CXX5_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7730 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1159309</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG11898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042263.1">
        <property type="nucleotide sequence ID" value="XM_018177195.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CXX5"/>
    <dbReference type="STRING" id="1460663.A0A177CXX5"/>
    <dbReference type="GeneID" id="28760681"/>
    <dbReference type="InParanoid" id="A0A177CXX5"/>
    <dbReference type="OrthoDB" id="2951834at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038883">
        <property type="entry name" value="AN11006-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056632">
        <property type="entry name" value="DUF7730"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085:SF7">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24864">
        <property type="entry name" value="DUF7730"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7730" evidence="2">
        <location>
            <begin position="106"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="313"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="313"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="343"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG11898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="363" mass="40397" checksum="DB58A3C1F59D0F96" modified="2016-09-07" version="1">MARSKRLAPTEELVEEASESCIREREATSAAHVGLQPPTKKRRIRSDILWDSLAKPPTDTSGSARAMRDPANASQLAALHDIGLPTPEASSLAEQEQLSKDVFPFLKLPAELRMDIYRCALCRDEPLLLDLASKDEKDGDAETPKPKKARNNAGVNVELLRTCSLVYKEARQIFYSENCFTLSIESSVATLAQLHQRSRSLIRSVTLAIPSHHDILDSFADMVRLGLRYCWGLRTFTIRLDVMLPDFDTLPAGHHGGIYANAFRILRWLPKGCKVILEGNVNESVKRVVAEEGRLLVELDEISYFRRQHQMSGRVSGSSFMPSQRDGKGMSNRTAEGGLAPDSGSSSAPERVYNTRSCRSMRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CYA5</accession>
    <name>A0A177CYA5_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">Endopolyphosphatase</fullName>
            <ecNumber evidence="3 12">3.6.1.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">CC84DRAFT_1159807</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the hydrolysis of inorganic polyphosphate (polyP) chains of many hundreds of phosphate residues into shorter lengths.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>[phosphate](n+1) + n H2O = (n+1) phosphate + n H(+)</text>
            <dbReference type="Rhea" id="RHEA:22452"/>
            <dbReference type="Rhea" id="RHEA-COMP:14280"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16838"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="EC" id="3.6.1.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the endopolyphosphatase PPN1 family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.10" evidence="3 12"/>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042878.1">
        <property type="nucleotide sequence ID" value="XM_018177336.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CYA5"/>
    <dbReference type="FunCoup" id="A0A177CYA5">
        <property type="interactions" value="190"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CYA5"/>
    <dbReference type="GeneID" id="28760822"/>
    <dbReference type="InParanoid" id="A0A177CYA5"/>
    <dbReference type="OrthoDB" id="348678at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000298">
        <property type="term" value="F:endopolyphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004309">
        <property type="term" value="F:exopolyphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006798">
        <property type="term" value="P:polyphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00842">
        <property type="entry name" value="MPP_ASMase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000082">
        <property type="entry name" value="Endopolyphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041805">
        <property type="entry name" value="ASMase/PPN1_MPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012358">
        <property type="entry name" value="EndopolyPtase_N1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10340:SF55">
        <property type="entry name" value="ENDOPOLYPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10340">
        <property type="entry name" value="SPHINGOMYELIN PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF027093">
        <property type="entry name" value="EndopolyPtase_N1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5 12" id="KW-0926">Vacuole</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008058745" description="Endopolyphosphatase" evidence="14">
        <location>
            <begin position="23"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="15">
        <location>
            <begin position="45"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="504"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="508"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR027093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="OAG12513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="735" mass="82730" checksum="4E1BD099C990FCEA" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CYK7</accession>
    <name>A0A177CYK7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tetratricopeptide repeat domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_1159918</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PPR family. P subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018043000.1">
        <property type="nucleotide sequence ID" value="XM_018177361.1"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CYK7"/>
    <dbReference type="GeneID" id="28760847"/>
    <dbReference type="InParanoid" id="A0A177CYK7"/>
    <dbReference type="OrthoDB" id="411857at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000266">
        <property type="entry name" value="Pentatricopeptide repeat domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050872">
        <property type="entry name" value="PPR_P_subfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057585">
        <property type="entry name" value="TPR_dom_fungi"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46128">
        <property type="entry name" value="MITOCHONDRIAL GROUP I INTRON SPLICING FACTOR CCM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46128:SF329">
        <property type="entry name" value="MITOCHONDRIAL GROUP I INTRON SPLICING FACTOR DMR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01535">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13041">
        <property type="entry name" value="PPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13812">
        <property type="entry name" value="PPR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24603">
        <property type="entry name" value="TPR_30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="383"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="domain" description="Tetratricopeptide repeat" evidence="3">
        <location>
            <begin position="503"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="983"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="1018"/>
            <end position="1048"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAG12635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="1289" mass="141974" checksum="D46226DD0A17D184" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CYL1</accession>
    <name>A0A177CYL1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_63224</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG11957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042322.1">
        <property type="nucleotide sequence ID" value="XM_018186955.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CYL1"/>
    <dbReference type="GeneID" id="28770441"/>
    <dbReference type="InParanoid" id="A0A177CYL1"/>
    <dbReference type="OrthoDB" id="3796147at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG11957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="230" mass="26581" checksum="ABE42F927145E80B" modified="2016-09-07" version="1">MMTKTALSEERHRLQKEMRKKDLELGSVRTLKLQLSVKTVQVENLSRTLAVASDREAEQSKQLSSALTELRGARDTQRCQSKNIAYLKSKNSHPGGDVQVTWELKRDIAFYFTQLDLAHQNYRIFTCSHNRLANLPDGNKSTRQHDASFTASDMFRNWQRDKVFMEEYRQHRAYLTKHHLAHQQNDPGRGDHAHQIQETCKYPITNSPIALLITTVIALDGYRGVVVQYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CYM7</accession>
    <name>A0A177CYM7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1159332</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG11920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018042285.1">
        <property type="nucleotide sequence ID" value="XM_018177202.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CYM7"/>
    <dbReference type="STRING" id="1460663.A0A177CYM7"/>
    <dbReference type="GeneID" id="28760688"/>
    <dbReference type="InParanoid" id="A0A177CYM7"/>
    <dbReference type="OrthoDB" id="10250354at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051964">
        <property type="entry name" value="Chaperone_stress_response"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44029">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44029:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="9"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="648"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="102"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="281"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="354"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="413"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="460"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="472"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="602"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="655"/>
            <end position="669"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG11920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="789" mass="86368" checksum="F1883D2AB6C24DA9" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CZR0</accession>
    <name>A0A177CZR0_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">V-type proton ATPase subunit C</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CC84DRAFT_173264</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity.</text>
    </comment>
    <comment type="function">
        <text evidence="5">Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. Reversibly leaves the enzyme after glucose depletion, causing the catalytic subcomplex V1 to detach from the V0 section.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the V-ATPase C subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018043360.1">
        <property type="nucleotide sequence ID" value="XM_018185455.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CZR0"/>
    <dbReference type="FunCoup" id="A0A177CZR0">
        <property type="interactions" value="395"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CZR0"/>
    <dbReference type="GeneID" id="28768941"/>
    <dbReference type="InParanoid" id="A0A177CZR0"/>
    <dbReference type="OrthoDB" id="6605928at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000221">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase, V1 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14785">
        <property type="entry name" value="V-ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.100:FF:000002">
        <property type="entry name" value="V-type proton ATPase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1460.10">
        <property type="entry name" value="subunit c (vma5p) of the yeast v-atpase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1180">
        <property type="entry name" value="Vacuolar atp synthase subunit c, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004907">
        <property type="entry name" value="ATPase_V1-cplx_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036132">
        <property type="entry name" value="Vac_ATP_synth_c_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10137">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10137:SF0">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03223">
        <property type="entry name" value="V-ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118203">
        <property type="entry name" value="Vacuolar ATP synthase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="4 6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00053565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAG12995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="393" mass="44198" checksum="CD32A91A350E42EF" modified="2016-09-07" version="1">MSKGTKYLLVSLPSSITPSNHHDEALDALRSTIGGDNGQTYPFAIPNFKIGTLDALVQQADDLAKLNNSCEQVVAKVGDSLKTILDGDEDRVQQHKTINDKPVDQYLRSFQWNKIKYRADKPIADLIDSLQKEIAGIDNDVKAKFSQYNQTKTSLAAAERKRTGNLSTKSLATVVNPRLIIQDSEYLDTHLIAVPNLQVKDFYKSYETISEKVVPRSAVEVAKDDEFTLFAVVTFKKTSTDFIHKCREKRWTPRDYKYKEGGKEEEAKEASQLEQDAKKLWGEALRLGRTGYSESAMIWVHVLALRVFVETVLRYGLPLDFICGLVQTNAKAAKKAKTNLDANYSYLGGNAFNRDNKGRPKKDDSALTSEMQAQGHLGDAEYSPYVYYEFEIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177D0K5</accession>
    <name>A0A177D0K5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Prefoldin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1183265</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the prefoldin subunit beta family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG12682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018043047.1">
        <property type="nucleotide sequence ID" value="XM_018180681.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177D0K5"/>
    <dbReference type="FunCoup" id="A0A177D0K5">
        <property type="interactions" value="95"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177D0K5"/>
    <dbReference type="GeneID" id="28764167"/>
    <dbReference type="InParanoid" id="A0A177D0K5"/>
    <dbReference type="OrthoDB" id="2015447at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044183">
        <property type="term" value="F:protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002777">
        <property type="entry name" value="PFD_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20903:SF0">
        <property type="entry name" value="PREFOLDIN SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20903">
        <property type="entry name" value="PREFOLDIN SUBUNIT 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01920">
        <property type="entry name" value="Prefoldin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG12682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="120" mass="13704" checksum="A6B0AEA5A427493A" modified="2016-09-07" version="1">MSIPNEKLQQILQEIGQKKAFAEQQLVIVRQQKVANSRESRMLQLTASEMESLPKETKVYEGVGKMFVCTPIPDVQKRLSSEDEKLKSELSNLKKKEDYLEKTYENSKNSIEQVLGGRTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177D194</accession>
    <name>A0A177D194_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HET-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1079538</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG13178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018043543.1">
        <property type="nucleotide sequence ID" value="XM_018173852.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177D194"/>
    <dbReference type="STRING" id="1460663.A0A177D194"/>
    <dbReference type="GeneID" id="28757338"/>
    <dbReference type="InParanoid" id="A0A177D194"/>
    <dbReference type="OrthoDB" id="3792241at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF16">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="53"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG13178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="343" mass="38759" checksum="5D57FAA008A5A466" modified="2016-09-07" version="1" fragment="single">MIRYWLQQCVDNHIECGRGLDNVKPTRLLDLAAPLGDQDIRLVLTEDIGEQPYATLSYRWGTVSGVNLMKSNYETFRTRIVLGTLPRSVQEAVRVCRGLSVRYLWVDALCIIQESGADLAREIAQMGSIYAGSLVTVAAANSTHHESGFIRERYPLRREDCIISGTDQEIIFSHELQYDNLNKHLMTLQKSKLNERGWVYQERMLSPRTVHFTAEEVIWECRELCQCYQCAGTSSARVGSSSSHVKNAFIHLHGLSNPATRDEKFPTVWSSILSAYTSTMLSNADDRLSALAGIAQFAIEKLDYNASYGLWLHGFLENLLWWVKPRQTADLASEVEALDHVPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177D224</accession>
    <name>A0A177D224_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1077359</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441548">
        <property type="protein sequence ID" value="OAG13190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018043555.1">
        <property type="nucleotide sequence ID" value="XM_018173749.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177D224"/>
    <dbReference type="STRING" id="1460663.A0A177D224"/>
    <dbReference type="GeneID" id="28757235"/>
    <dbReference type="InParanoid" id="A0A177D224"/>
    <dbReference type="OrthoDB" id="3788048at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG13190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="261" mass="30293" checksum="13652811E54C343D" modified="2016-09-07" version="1">MFKPLSSAYSKQLTKYLHNAQGLLPVKKGDFFPLFWEAWTCSFQEKTILRSFQATGIITLSLEIILKRFKKSTLEQEERENSSSVLSGEDWLKLHSLIRSESSREAQKLSRSLHHILIQNELLHIEVEGLSKALLSKKKHEKKSKPLDLQQRQEYRGGAVFWSPSKVREAQFRQRIKDQEAEKQQLEKARKKAEKASKKVHQLQEKEERARKALEPATKPIQKKQRREVVAEGRGGDQGRDPSSVRTTRVGRNIKLPQKFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2023-06-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BTQ9</accession>
    <name>A0A177BTQ9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_1158609</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441566">
        <property type="protein sequence ID" value="OAF98555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018028921.1">
        <property type="nucleotide sequence ID" value="XM_018177055.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BTQ9"/>
    <dbReference type="GeneID" id="28760541"/>
    <dbReference type="InParanoid" id="A0A177BTQ9"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAF98555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="68" mass="7322" checksum="A72CBBD7990037FC" modified="2016-09-07" version="1">MRPTRVGTTHLISRIANVNSGSSTRLNLRSQVPQQGLITGSNVGKKIEMQMIFQTMISPEGLRVGGGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BTT3</accession>
    <name>A0A177BTT3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">NAD(P)-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CC84DRAFT_1105486</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441564">
        <property type="protein sequence ID" value="OAF98822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029188.1">
        <property type="nucleotide sequence ID" value="XM_018175097.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BTT3"/>
    <dbReference type="STRING" id="1460663.A0A177BTT3"/>
    <dbReference type="GeneID" id="28758583"/>
    <dbReference type="InParanoid" id="A0A177BTT3"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF282">
        <property type="entry name" value="WW DOMAIN-CONTAINING OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008057316" description="NAD(P)-binding protein" evidence="4">
        <location>
            <begin position="26"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAF98822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="122" mass="13188" checksum="FDE2D3F1072418CC" modified="2016-09-07" version="1">MNKPTATDHLGPFLVANILLPLLQSISVASRDSDVRVINVSRTAIDLVPSGHSFSLLEAWNNDSGGECSPLRFLHRYGHSKVANVLCTTELQRQLDQESSRILVAAVQPGVVATPRSEKSLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BUS0</accession>
    <name>A0A177BUS0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Geranylgeranyl transferas-like protein type i beta subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CC84DRAFT_1169880</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein prenyltransferase subunit beta family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441564">
        <property type="protein sequence ID" value="OAF98720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029086.1">
        <property type="nucleotide sequence ID" value="XM_018179778.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BUS0"/>
    <dbReference type="FunCoup" id="A0A177BUS0">
        <property type="interactions" value="4"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177BUS0"/>
    <dbReference type="GeneID" id="28763264"/>
    <dbReference type="InParanoid" id="A0A177BUS0"/>
    <dbReference type="OrthoDB" id="24893at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005953">
        <property type="term" value="C:CAAX-protein geranylgeranyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004662">
        <property type="term" value="F:CAAX-protein geranylgeranyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045089">
        <property type="entry name" value="PGGT1B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001330">
        <property type="entry name" value="Prenyltrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11774">
        <property type="entry name" value="GERANYLGERANYL TRANSFERASE TYPE BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11774:SF4">
        <property type="entry name" value="GERANYLGERANYL TRANSFERASE TYPE-1 SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00432">
        <property type="entry name" value="Prenyltrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="Terpenoid cyclases/Protein prenyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0637">Prenyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Prenyltransferase alpha-alpha toroid" evidence="8">
        <location>
            <begin position="14"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAF98720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="433" mass="48356" checksum="E2EDAAA221CB969F" modified="2016-09-07" version="1">MAPGLTRDAEESRLNYAAHTRYWRRNLKTFLPRQYTGNDCNRMTLAAFILSALDILGDLPAALSREERAGYIDWVYSCQLPEGGFRPAPATDLGAARTPKNQIWDPFHVAGTFFALLILITLGDGLENVKRREILQWLTKLQRPDGGFGETLGEQDRVEGGNDSRFGFMVAAVRWMLRGNLEGPVDGVPDIDVDAFVRCVQAAESYDGGLSEAPYHEAHGGFTSCAISALFFLDRLPTKNPDGRQRGLRNLPMTLHWLASRQTLTIDEEDAAETYSDETDSAATCDDSHSFMKLHNYPSMRGKLSFERQPPVHAEIKWVGMNGRENKIGDTCYAYWVCAPLKLLGHLDIIDPKPIRRWLLDRTQHLVGGFGKLPGDHPDPQHSFLGLMVLSMFGEAGLQNVDTALCITERAKDHLESLPWRRKLLGSDSIGEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BUU1</accession>
    <name>A0A177BUU1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">T6SS Phospholipase effector Tle1-like catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1264622</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441563">
        <property type="protein sequence ID" value="OAF99074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029440.1">
        <property type="nucleotide sequence ID" value="XM_018185323.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BUU1"/>
    <dbReference type="STRING" id="1460663.A0A177BUU1"/>
    <dbReference type="GeneID" id="28768809"/>
    <dbReference type="InParanoid" id="A0A177BUU1"/>
    <dbReference type="OrthoDB" id="3057168at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018712">
        <property type="entry name" value="Tle1-like_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33840:SF16">
        <property type="entry name" value="DUF2235 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09994">
        <property type="entry name" value="T6SS_Tle1-like_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T6SS Phospholipase effector Tle1-like catalytic" evidence="2">
        <location>
            <begin position="10"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="466"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAF99074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="595" mass="67726" checksum="FD62A8688DCA335A" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BV73</accession>
    <name>A0A177BV73_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_429622</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441566">
        <property type="protein sequence ID" value="OAF98558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018028924.1">
        <property type="nucleotide sequence ID" value="XM_018186208.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BV73"/>
    <dbReference type="GeneID" id="28769694"/>
    <dbReference type="InParanoid" id="A0A177BV73"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="229"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAF98558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="329" mass="36799" checksum="B1D8E49CA758165C" modified="2016-09-07" version="1">MVLRAISRLTASGYLPGLPDAAGLMTSPSGSPMSWHCSCVAMGSTCIGSLSAQAGSRLASLVKQRYNMALSQLSSAAAFPLTALSLRMWRHLATISFSTSTSPTPFPPETLSQLSIQPLLPLDLPSHSFLLFRRRHSSYTRPKHQLQHDLLLLRLRLRRLHSLSWRRAQRGRHHNPSPRPRRRRAGEDGKEIVVLSRNWDWGVGRGCCNCSCRCRSGQPGGLCRSNLDLGWGIVFFGYGHWALRLVLLFFFWLHRWALNGVRHGRVRAICIIPTRLRSPCSFYPHQHTSATGTYQGWNLLSSNSSCARTAWRSSHLSHPTSSTLSTPLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BVG4</accession>
    <name>A0A177BVG4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">VWFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CC84DRAFT_1233267</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome subunit S5A family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441563">
        <property type="protein sequence ID" value="OAF98960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029326.1">
        <property type="nucleotide sequence ID" value="XM_018183784.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BVG4"/>
    <dbReference type="FunCoup" id="A0A177BVG4">
        <property type="interactions" value="953"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177BVG4"/>
    <dbReference type="GeneID" id="28767270"/>
    <dbReference type="InParanoid" id="A0A177BVG4"/>
    <dbReference type="OrthoDB" id="1731724at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036435">
        <property type="term" value="F:K48-linked polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032436">
        <property type="term" value="P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043248">
        <property type="term" value="P:proteasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01452">
        <property type="entry name" value="VWA_26S_proteasome_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.410:FF:000005">
        <property type="entry name" value="26S proteasome non-ATPase regulatory subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.3990:FF:000001">
        <property type="entry name" value="26S proteasome regulatory subunit S5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.3990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027040">
        <property type="entry name" value="PSMD4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10223">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10223:SF0">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13519">
        <property type="entry name" value="VWA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0647">Proteasome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="4">
        <location>
            <begin position="5"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="196"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="235"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="196"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="235"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="280"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAF98960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="293" mass="31117" checksum="018EB1EF9C719233" modified="2016-09-07" version="1">MVLEASMIIVDNSEASRNGDYVPSRWEAQADAVNLIFSAKTGANPESSVGLMSMGGSQPEILTTLTTDIGKVLDGLHRTKIKGTSHFSTGINVAALALKHRQNKSQKQRIVLFTCSPIEEEEKDLVKLSKRMKKNGISVDIIAFGELGDDTTRKLEKFSEACQSAEGSHLAIIQPSSNLLSDSLITTPILGGDASSGGAGASNAGGEGGDSGGNSFEFGVDPSVDPELALALRMSFEEEKARQEKEKKSKEAAEGKSELEPVAEGDEKQPLLDDQGEASGSKDRKDDDKMDTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BVX8</accession>
    <name>A0A177BVX8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">ABC multidrug transporter-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CC84DRAFT_421577</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441564">
        <property type="protein sequence ID" value="OAF98717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029083.1">
        <property type="nucleotide sequence ID" value="XM_018186162.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A177BVX8">
        <property type="interactions" value="247"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177BVX8"/>
    <dbReference type="GeneID" id="28769648"/>
    <dbReference type="InParanoid" id="A0A177BVX8"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18597">
        <property type="entry name" value="ABC_6TM_YOR1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18606">
        <property type="entry name" value="ABC_6TM_YOR1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000565">
        <property type="entry name" value="ABC bile acid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002040">
        <property type="entry name" value="ABC multidrug transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000010">
        <property type="entry name" value="Multidrug resistance-associated ABC transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF464">
        <property type="entry name" value="ABC-TYPE TRANSPORTER CICA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="363"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="389"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="464"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="503"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="895"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="933"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1012"/>
            <end position="1031"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1037"/>
            <end position="1054"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1124"/>
            <end position="1142"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="193"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="611"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="900"/>
            <end position="1175"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="1211"/>
            <end position="1450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="571"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="603"/>
            <end position="616"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OAF98717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="1461" mass="163032" checksum="290C6D6080F648E0" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BW18</accession>
    <name>A0A177BW18_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Yeast cell wall synthesis Kre9/Knh1-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">CC84DRAFT_1223420</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441563">
        <property type="protein sequence ID" value="OAF99140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029506.1">
        <property type="nucleotide sequence ID" value="XM_018183487.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BW18"/>
    <dbReference type="STRING" id="1460663.A0A177BW18"/>
    <dbReference type="GeneID" id="28766973"/>
    <dbReference type="InParanoid" id="A0A177BW18"/>
    <dbReference type="OrthoDB" id="5589325at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018466">
        <property type="entry name" value="Kre9/Knh1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052982">
        <property type="entry name" value="SRP1/TIP1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40633:SF1">
        <property type="entry name" value="GPI ANCHORED SERINE-THREONINE RICH PROTEIN (AFU_ORTHOLOGUE AFUA_1G03630)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40633">
        <property type="entry name" value="MATRIX PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G05410)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10342">
        <property type="entry name" value="Kre9_KNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008057372" description="Yeast cell wall synthesis Kre9/Knh1-like N-terminal domain-containing protein" evidence="3">
        <location>
            <begin position="20"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="Yeast cell wall synthesis Kre9/Knh1-like N-terminal" evidence="4">
        <location>
            <begin position="27"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="156"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="163"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="OAF99140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="218" mass="21543" checksum="1CF072D1CD830839" modified="2016-09-07" version="1">MRFFEVVLSGAALISAAFAVEFNSWPDSVKAGQTVTLTYSPKDAATTIILRKGPSTNLDTLQTLTTTSTGGSFEWAVPSSLENGDDYAFEIRQAGAEPNYSGQFALSGGVASAVSSSAYSTKASSAAASSTAHSTEVSTTVKTSVVTSAASASASGSIVPSAGANSTISTGSPSATKSQASGSPTGSSPPVENTGAASSFGVNAAALFGAIGAFAYFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BW20</accession>
    <name>A0A177BW20_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">FAD-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CC84DRAFT_1231954</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441561">
        <property type="protein sequence ID" value="OAF99612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029978.1">
        <property type="nucleotide sequence ID" value="XM_018183745.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BW20"/>
    <dbReference type="STRING" id="1460663.A0A177BW20"/>
    <dbReference type="GeneID" id="28767231"/>
    <dbReference type="InParanoid" id="A0A177BW20"/>
    <dbReference type="OrthoDB" id="2151789at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF54">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="5">
        <location>
            <begin position="51"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAF99612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="486" mass="52670" checksum="AEEEF7F6BC74BB87" modified="2016-09-07" version="1">MHVPSPWTVPCTGNARLTCSVLQHLFPSNETFTGGSQYYQTLVQVPYSAICEKDPACFVTPESSDDVSLIMRVLTATNTKFAIRSWGHLPLPGWNAVGSDGVVISLERLQKKVLSADRKYATLGPGQNWGTVYDWCVANGVQVVGGRDIGVGVGGFLLGGGISLFNDKKGLGLDQVVRYEIVLPSGKVVNATTKKNADLYKSLKGGLSNFGIVTEFEVITSDIIDINYEVNLYHKNVTRAILSAYADFLREDGPGDAVVQLEVSQNATLVFFGHIGHVSSAPEFKAFRSIPVMRPFLPPSNGTVASFLSAALGSSGNGANGESPGSYYHTSVAQKIPDSKLILEAYDEYLKAATMLEPGMAMYFAPQGFTSALVKAGKALNGGNVMGLDDVPQFWHDTYVTFPNVNQYGLAQKAVDSWEAAWTKKAKKEGSFLPIIYSNNGNIHSRPLSGYGQKNFDFIKKTAKKYDPNGVMQTLQNDGFLIRKEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2023-06-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BWD1</accession>
    <name>A0A177BWD1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_419704</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441564">
        <property type="protein sequence ID" value="OAF98676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029042.1">
        <property type="nucleotide sequence ID" value="XM_018186151.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BWD1"/>
    <dbReference type="GeneID" id="28769637"/>
    <dbReference type="InParanoid" id="A0A177BWD1"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAF98676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="217" mass="24550" checksum="67F5542E267EE87F" modified="2016-09-07" version="1">MLQLGRRRSMLHVPRRAFLLHTASCEPSINFLQITPDPPIISTTLCLRMQTRNLERKELSRRGIGISRLNAQRDYVAARGVAAPHRLTPSAPRWLVCSPSYQRCAITLPPVPVPGEAFRVTGTARTLWLHARCHSFRILDQHCRILFSRSIFERVGPRVRERSSAPANPADCSCECEKCKVNLEEVAQAVRHCNWGFPAALSWAYGLITIVPTRIYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BWS9</accession>
    <name>A0A177BWS9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pyruvate dehydrogenase E1 component subunit alpha</fullName>
            <ecNumber evidence="5">1.2.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CC84DRAFT_1169513</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>N(6)-[(R)-lipoyl]-L-lysyl-[protein] + pyruvate + H(+) = N(6)-[(R)-S(8)-acetyldihydrolipoyl]-L-lysyl-[protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:19189"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:10478"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83111"/>
            <dbReference type="EC" id="1.2.4.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="1.2.4.1" evidence="5"/>
    <dbReference type="EMBL" id="KV441562">
        <property type="protein sequence ID" value="OAF99410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029776.1">
        <property type="nucleotide sequence ID" value="XM_018179676.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BWS9"/>
    <dbReference type="FunCoup" id="A0A177BWS9">
        <property type="interactions" value="598"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177BWS9"/>
    <dbReference type="GeneID" id="28763162"/>
    <dbReference type="InParanoid" id="A0A177BWS9"/>
    <dbReference type="OrthoDB" id="10256198at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042645">
        <property type="term" value="C:mitochondrial nucleoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045254">
        <property type="term" value="C:pyruvate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004739">
        <property type="term" value="F:pyruvate dehydrogenase (acetyl-transferring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007124">
        <property type="term" value="P:pseudohyphal growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006086">
        <property type="term" value="P:pyruvate decarboxylation to acetyl-CoA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd02000">
        <property type="entry name" value="TPP_E1_PDC_ADC_BCADC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000013">
        <property type="entry name" value="Pyruvate dehydrogenase E1 component subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001017">
        <property type="entry name" value="DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050642">
        <property type="entry name" value="PDH_E1_Alpha_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017597">
        <property type="entry name" value="Pyrv_DH_E1_asu_subgrp-y"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03182">
        <property type="entry name" value="PDH_E1_alph_y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11516:SF60">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE E1 COMPONENT SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11516">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE E1 COMPONENT, ALPHA SUBUNIT BACTERIAL AND ORGANELLAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00676">
        <property type="entry name" value="E1_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 5" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="Dehydrogenase E1 component" evidence="6">
        <location>
            <begin position="84"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAF99410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="424" mass="46967" checksum="BAE468D5595169EF" modified="2016-09-07" version="1">MLSRTIRRSIASPLRRNAFVPAAARPAFRTVTTDAASAHAEAVPTEDDKPFEVRLSDESFETYELDPPAYTLDTTKAELKQMYYDMVAMRRMEMAADRLYKEKKIRGFCHLSTGQEAVAVGIEHAIERADHLITAYRCHGFAMMRGGTIKSIIGELLGRREGIAYGKGGSMHMFAPGFYGGNGIVGAQVPVGAGIAFANAYENKKNVTLALYGDGASNQGQVFEAYNMAKLWNLPIIFACENNKYGMGTAANRSSAITDYYKRGQYIPGLKINGMDVLAVKAATQFGKEWCAAGKGPLVYEFVTYRYGGHSMSDPGTTYRTREEIQRMRSTQDPIAGLKQKLLDWSVVTEEELKSIDKKARANVDAEVAEAEKMAPPEAIPKVLFEDIYVRGSEPEFLRGRIPEENFYYAEADLGKEKDSPART</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BWW5</accession>
    <name>A0A177BWW5_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_1200407</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441564">
        <property type="protein sequence ID" value="OAF98809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029175.1">
        <property type="nucleotide sequence ID" value="XM_018181661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BWW5"/>
    <dbReference type="STRING" id="1460663.A0A177BWW5"/>
    <dbReference type="GeneID" id="28765147"/>
    <dbReference type="InParanoid" id="A0A177BWW5"/>
    <dbReference type="OrthoDB" id="1933717at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43669">
        <property type="entry name" value="5-KETO-D-GLUCONATE 5-REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43669:SF3">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G03445)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoreductase" evidence="3">
        <location>
            <begin position="40"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAF98809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="300" mass="32376" checksum="0F5998C057EA0B77" modified="2016-09-07" version="1">MSAQLDPNMLTAPFQLTKAMHRDVYPAVDPKRLAPLASDKVILITGSGGGLGYAVAKTWTLANAKGVVLVGRDEQKLDSVAKELKGNILVASGDITKEDDVKAIFEKAIAKFGAVDVVLNAAGIVNYGTIGEMEPSQWWAEHEINVKATYILAHYLHNFNKDRTTTFINLVSLGASMTNPGLSSLSTSQLAATKLGEHLDLELSNVRVFSIHPGIVEAKDGRGTVIDAMTPFAKDQPELTGAFTLYLLKPEADVLRGGYVSVNWDVEEIEKHGDEIKAGRLLRLGHINAKVGPDGHPWAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BXL7</accession>
    <name>A0A177BXL7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_358809</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441560">
        <property type="protein sequence ID" value="OAG00065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030430.1">
        <property type="nucleotide sequence ID" value="XM_018185893.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BXL7"/>
    <dbReference type="STRING" id="1460663.A0A177BXL7"/>
    <dbReference type="GeneID" id="28769379"/>
    <dbReference type="InParanoid" id="A0A177BXL7"/>
    <dbReference type="OrthoDB" id="8026949at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051714">
        <property type="entry name" value="Znf_CCHC_NABP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23002">
        <property type="entry name" value="ZINC FINGER CCHC DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="22"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="189"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="218"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="241"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG00065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="312" mass="35130" checksum="2AEC2529CD88FAD2" modified="2016-09-07" version="1">MCSHNKADCSNPKVERPFTGTCNLCGVEGHSARNCPSATCKLCGEAGHKALECTSRRKVDWTGLPELDAEEAWTKLVDASEEKDLDVFRIALRAYARAIDGAFIASEVEQALRDSDLNVFLIALRQEVAPHMTIVDLIGNPDREYVLTIQLSAKPRRAKLAQGWPADAAENMERLRSAGFVQDRGVPLCSNCNELGHIKKHCKQEVVEREKMTPIVTCVYCQEEGHRARDCPKERVNPYACKNCKQEGHKAADCPEPRSAEGVECHKCNETGHFSRDVSLFNFYEWKNQRLMFFEVPKRRSSSSSNLPQLRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BXP4</accession>
    <name>A0A177BXP4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glycoprotease family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1105134</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441563">
        <property type="protein sequence ID" value="OAF99099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018029465.1">
        <property type="nucleotide sequence ID" value="XM_018175084.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BXP4"/>
    <dbReference type="STRING" id="1460663.A0A177BXP4"/>
    <dbReference type="GeneID" id="28758570"/>
    <dbReference type="InParanoid" id="A0A177BXP4"/>
    <dbReference type="OrthoDB" id="10259622at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="619"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="393"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="530"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="649"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="803"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="530"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="562"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="804"/>
            <end position="814"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAF99099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1025" mass="111704" checksum="13DFA450F3672956" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BYR3</accession>
    <name>A0A177BYR3_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative NAD dependent epimerase/dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1168516</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441559">
        <property type="protein sequence ID" value="OAG00415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030780.1">
        <property type="nucleotide sequence ID" value="XM_018179416.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BYR3"/>
    <dbReference type="STRING" id="1460663.A0A177BYR3"/>
    <dbReference type="GeneID" id="28762902"/>
    <dbReference type="InParanoid" id="A0A177BYR3"/>
    <dbReference type="OrthoDB" id="10262413at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051783">
        <property type="entry name" value="NAD(P)-dependent_oxidoreduct"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48079:SF5">
        <property type="entry name" value="DEPENDENT EPIMERASE_DEHYDRATASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G00180)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48079">
        <property type="entry name" value="PROTEIN YEEZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="2">
        <location>
            <begin position="5"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG00415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="315" mass="34036" checksum="2791F59389698E65" modified="2016-09-07" version="1">MSKTIFITGGSGYIGAVIIEYAVAQGYSVTALSRSESSDSKLRALGANPVRGDIKSLDVLTAEASKADIVINMADAIASDFNISQDERWATNYAANNALAAGVKGTNKPLIITSGAMTAQPHPEDEETDEKSPGWPEGHIYARGFESNKQTYLDQGVRVAYVRLAPYVYGRGGSGVRLYMDSFAPRGKGFFIKPGTALTTTVHVEDAARLYLILAEKAVAGESYNATSETDIQQKQISEAICETLGFPCEELDVEEVKAKMGMFLAIFMTAKCRSSNKKAREQLGWSVQAEKGILEEIRSGSYVDVAKAMKKQAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BZF3</accession>
    <name>A0A177BZF3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nucleolar protein 58</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CC84DRAFT_1199558</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Required for pre-18S rRNA processing. May bind microtubules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NOP5/NOP56 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441560">
        <property type="protein sequence ID" value="OAF99917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030283.1">
        <property type="nucleotide sequence ID" value="XM_018181626.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BZF3"/>
    <dbReference type="FunCoup" id="A0A177BZF3">
        <property type="interactions" value="1562"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177BZF3"/>
    <dbReference type="GeneID" id="28765112"/>
    <dbReference type="InParanoid" id="A0A177BZF3"/>
    <dbReference type="OrthoDB" id="6780543at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031428">
        <property type="term" value="C:box C/D methylation guide snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017069">
        <property type="term" value="F:snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000494">
        <property type="term" value="P:box C/D sno(s)RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000480">
        <property type="term" value="P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000472">
        <property type="term" value="P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902570">
        <property type="term" value="P:protein localization to nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000452">
        <property type="term" value="P:snoRNA guided rRNA 2'-O-methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.246.90:FF:000003">
        <property type="entry name" value="Nucleolar protein 58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.4070:FF:000001">
        <property type="entry name" value="Probable Nucleolar protein 58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.4070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.90">
        <property type="entry name" value="Nop domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045056">
        <property type="entry name" value="Nop56/Nop58"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012974">
        <property type="entry name" value="NOP58/56_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042239">
        <property type="entry name" value="Nop_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002687">
        <property type="entry name" value="Nop_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036070">
        <property type="entry name" value="Nop_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012976">
        <property type="entry name" value="NOSIC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10894">
        <property type="entry name" value="NUCLEOLAR PROTEIN 5 NUCLEOLAR PROTEIN NOP5 NOP58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10894:SF1">
        <property type="entry name" value="NUCLEOLAR PROTEIN 58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01798">
        <property type="entry name" value="Nop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08156">
        <property type="entry name" value="NOP5NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00931">
        <property type="entry name" value="NOSIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89124">
        <property type="entry name" value="Nop domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51358">
        <property type="entry name" value="NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Nop" evidence="10">
        <location>
            <begin position="283"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="381"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="442"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="385"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="474"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="506"/>
            <end position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OAF99917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="574" mass="62097" checksum="261650B6A8A7CB29" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177BZJ9</accession>
    <name>A0A177BZJ9_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_1168714</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441559">
        <property type="protein sequence ID" value="OAG00645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031010.1">
        <property type="nucleotide sequence ID" value="XM_018179465.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177BZJ9"/>
    <dbReference type="STRING" id="1460663.A0A177BZJ9"/>
    <dbReference type="GeneID" id="28762951"/>
    <dbReference type="InParanoid" id="A0A177BZJ9"/>
    <dbReference type="OrthoDB" id="443402at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056693">
        <property type="entry name" value="DUF7791"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF5">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25053">
        <property type="entry name" value="DUF7791"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="2">
        <location>
            <begin position="263"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7791" evidence="3">
        <location>
            <begin position="548"/>
            <end position="691"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAG00645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="847" mass="96667" checksum="D8C1D8E1CCDDD6FD" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C048</accession>
    <name>A0A177C048_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HAD-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_277318</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441558">
        <property type="protein sequence ID" value="OAG01164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031529.1">
        <property type="nucleotide sequence ID" value="XM_018185731.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C048"/>
    <dbReference type="STRING" id="1460663.A0A177C048"/>
    <dbReference type="GeneID" id="28769217"/>
    <dbReference type="InParanoid" id="A0A177C048"/>
    <dbReference type="OrthoDB" id="2363873at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="entry name" value="Putative phosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051540">
        <property type="entry name" value="S-2-haloacid_dehalogenase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01493">
        <property type="entry name" value="HAD-SF-IA-v2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43316:SF3">
        <property type="entry name" value="HALOACID DEHALOGENASE, TYPE II (AFU_ORTHOLOGUE AFUA_2G07750)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43316">
        <property type="entry name" value="HYDROLASE, HALOACID DELAHOGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00413">
        <property type="entry name" value="HADHALOGNASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG01164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="263" mass="30257" checksum="4F3755B132E003DA" modified="2016-09-07" version="1">MAARKQKVIFFDLMGTCCDWLTSLLPALHECPPHSSLTPAEPRLRELAIAWREGFFQEIHARFNRGDPNEDIDITHRRVLDRLLETNGIEFDTWNESVRDKLVRQWHFQTPWPDVLLALHQLREDGRWFLVVLANGTARLQLDIAQSSGLPFHTLLSSELLGFTKPDPAIYRKAMDLVRLSPNDCIMLASHLYDLAAAKSAGMRTIYIHRDTEDTDTEIVDLRGEHAYVDLYFDGRERDQQSAQEVGFLAAAEYLIRTEPRSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C0C1</accession>
    <name>A0A177C0C1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_1209037</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441558">
        <property type="protein sequence ID" value="OAG00925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031290.1">
        <property type="nucleotide sequence ID" value="XM_018182197.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C0C1"/>
    <dbReference type="STRING" id="1460663.A0A177C0C1"/>
    <dbReference type="GeneID" id="28765683"/>
    <dbReference type="InParanoid" id="A0A177C0C1"/>
    <dbReference type="OrthoDB" id="4491390at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053178">
        <property type="entry name" value="Osmoadaptation_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38111">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="11"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="535"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="583"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="591"/>
            <end position="608"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAG00925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="608" mass="66432" checksum="4B8291F17608D6D7" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C0F1</accession>
    <name>A0A177C0F1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1222411</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441560">
        <property type="protein sequence ID" value="OAG00090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030455.1">
        <property type="nucleotide sequence ID" value="XM_018183365.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C0F1"/>
    <dbReference type="STRING" id="1460663.A0A177C0F1"/>
    <dbReference type="GeneID" id="28766851"/>
    <dbReference type="InParanoid" id="A0A177C0F1"/>
    <dbReference type="OrthoDB" id="5288318at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="162"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG00090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="379" mass="41593" checksum="3FB83D2E9E178355" modified="2016-09-07" version="1">MVVLVDLDDPDDDGFTPGPAAAADDGRPNPNVNGFSAALSCYPIARQLARQLDLNSLHDLSRTCRQFRANLLEYRDQLIRHTLHCDFDVEDEAIPRPTGSRLLTSGRVARCARDMVAECQRCAAVVCRNCTIKPPPAPTLRARHRRLCRTCTRAPLAFLTAAPRPRASSESSLPGTPDSPRPALLDDAADAPRAFTAPAFERTPCICADTVWLCQPCGQHLKNADTMYVRAWTWRTRYSHYLGGVGTGAGEGNEGVECGRGAQCLAARVVEHEVDCNASDPAYSGSPETGERWTGTSYYAQEIEGIGGVVKMKLKKQVRVGECVKVYEDERDKSIRWLEREVSGRLRSWCSWCERVVLGDKDRAEVRGGRAPSSAGSEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C1A1</accession>
    <name>A0A177C1A1_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Alcohol oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">CC84DRAFT_1155604</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441559">
        <property type="protein sequence ID" value="OAG00659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031024.1">
        <property type="nucleotide sequence ID" value="XM_018176944.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C1A1"/>
    <dbReference type="STRING" id="1460663.A0A177C1A1"/>
    <dbReference type="GeneID" id="28760430"/>
    <dbReference type="InParanoid" id="A0A177C1A1"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF115">
        <property type="entry name" value="DEHYDROGENASE XPTC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008057569" evidence="4">
        <location>
            <begin position="17"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="5">
        <location>
            <begin position="296"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="551"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="594"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="OAG00659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="614" mass="65689" checksum="7184061E37B8144D" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C1R9</accession>
    <name>A0A177C1R9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ZW10 C-terminal helical domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_1168659</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441559">
        <property type="protein sequence ID" value="OAG00570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018030935.1">
        <property type="nucleotide sequence ID" value="XM_018179452.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C1R9"/>
    <dbReference type="STRING" id="1460663.A0A177C1R9"/>
    <dbReference type="GeneID" id="28762938"/>
    <dbReference type="InParanoid" id="A0A177C1R9"/>
    <dbReference type="OrthoDB" id="534815at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990423">
        <property type="term" value="C:RZZ complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007094">
        <property type="term" value="P:mitotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046362">
        <property type="entry name" value="Zw10/DSL1_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055148">
        <property type="entry name" value="ZW10_C_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12205">
        <property type="entry name" value="CENTROMERE/KINETOCHORE PROTEIN ZW10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12205:SF0">
        <property type="entry name" value="CENTROMERE_KINETOCHORE PROTEIN ZW10 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22766">
        <property type="entry name" value="ZW10_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ZW10 C-terminal helical" evidence="3">
        <location>
            <begin position="713"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="421"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="445"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="43"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="24"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="461"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="479"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="492"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="512"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="536"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAG00570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="866" mass="96076" checksum="64927CD1B5D53746" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C205</accession>
    <name>A0A177C205_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA helicase</fullName>
            <ecNumber evidence="4">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">CC84DRAFT_1168332</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15 22">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the SWR1 chromatin-remodeling complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family. SWR1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="4"/>
    <dbReference type="EMBL" id="KV441558">
        <property type="protein sequence ID" value="OAG01191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031556.1">
        <property type="nucleotide sequence ID" value="XM_018179369.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A0A177C205">
        <property type="interactions" value="197"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177C205"/>
    <dbReference type="GeneID" id="28762855"/>
    <dbReference type="InParanoid" id="A0A177C205"/>
    <dbReference type="OrthoDB" id="372624at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000812">
        <property type="term" value="C:Swr1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000005">
        <property type="entry name" value="Photoperiod-independent early flowering 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000655">
        <property type="entry name" value="Protein PHOTOPERIOD-INDEPENDENT EARLY FLOWERING 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.850">
        <property type="entry name" value="SWI2/SNF2 ATPases, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014012">
        <property type="entry name" value="HSA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050520">
        <property type="entry name" value="INO80/SWR1_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45685:SF1">
        <property type="entry name" value="HELICASE SRCAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45685">
        <property type="entry name" value="HELICASE SRCAP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07529">
        <property type="entry name" value="HSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51204">
        <property type="entry name" value="HSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0010">Activator</keyword>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0804">Transcription</keyword>
    <keyword evidence="10" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HSA" evidence="19">
        <location>
            <begin position="328"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="17">
        <location>
            <begin position="799"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="18">
        <location>
            <begin position="1391"/>
            <end position="1544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="461"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="715"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1614"/>
            <end position="1646"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1659"/>
            <end position="1693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="24"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="134"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="183"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="262"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="496"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="525"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="567"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="604"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="625"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="647"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="1620"/>
            <end position="1631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="1659"/>
            <end position="1686"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="OAG01191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="1693" mass="189709" checksum="25916926C000C65E" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C2R3</accession>
    <name>A0A177C2R3_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">chitin synthase</fullName>
            <ecNumber evidence="2">2.4.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CC84DRAFT_1220947</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.4.1.16" evidence="2"/>
    <dbReference type="EMBL" id="KV441557">
        <property type="protein sequence ID" value="OAG01441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031806.1">
        <property type="nucleotide sequence ID" value="XM_018183211.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C2R3"/>
    <dbReference type="FunCoup" id="A0A177C2R3">
        <property type="interactions" value="87"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177C2R3"/>
    <dbReference type="GeneID" id="28766697"/>
    <dbReference type="InParanoid" id="A0A177C2R3"/>
    <dbReference type="OrthoDB" id="26569at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005935">
        <property type="term" value="C:cellular bud neck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004100">
        <property type="term" value="F:chitin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902404">
        <property type="term" value="P:mitotic actomyosin contractile ring contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd04190">
        <property type="entry name" value="Chitin_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004835">
        <property type="entry name" value="Chitin_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013616">
        <property type="entry name" value="Chitin_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914:SF38">
        <property type="entry name" value="CHITIN SYNTHASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01644">
        <property type="entry name" value="Chitin_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08407">
        <property type="entry name" value="Chitin_synth_1N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="698"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="734"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="768"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="812"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="939"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="972"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin synthase N-terminal" evidence="11">
        <location>
            <begin position="277"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="39"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1023"/>
            <end position="1060"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="39"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="61"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="119"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="216"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="1026"/>
            <end position="1035"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1036"/>
            <end position="1060"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OAG01441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="1060" mass="119091" checksum="8C2DA4648CFABB89" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C3P9</accession>
    <name>A0A177C3P9_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">AA1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1220816</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441557">
        <property type="protein sequence ID" value="OAG01290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018031655.1">
        <property type="nucleotide sequence ID" value="XM_018183204.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C3P9"/>
    <dbReference type="STRING" id="1460663.A0A177C3P9"/>
    <dbReference type="GeneID" id="28766690"/>
    <dbReference type="InParanoid" id="A0A177C3P9"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008057706" description="AA1-like domain-containing protein" evidence="2">
        <location>
            <begin position="22"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG01290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="161" mass="17294" checksum="E00326AF86E47385" modified="2016-09-07" version="1">MLRQALATAVTFLSLSHMASGAIVFLSNCHQDYYSGQYQWSEMDYFTNTPPTASYPDGKKPAGKTPSIEAKGPNTGGRDDRVHWEGRKTCGNFSDTTFCATIAADAGGKSKGTYVGSGSNGFGTKFDCYSEGGERYVYAINPPDATGLTSSCYAIYYCSTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C4B7</accession>
    <name>A0A177C4B7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Peptidase S28</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CC84DRAFT_1179266</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S28 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441556">
        <property type="protein sequence ID" value="OAG02345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032710.1">
        <property type="nucleotide sequence ID" value="XM_018180404.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C4B7"/>
    <dbReference type="GeneID" id="28763890"/>
    <dbReference type="InParanoid" id="A0A177C4B7"/>
    <dbReference type="OrthoDB" id="1735038at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070008">
        <property type="term" value="F:serine-type exopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000251">
        <property type="entry name" value="Extracelular serine carboxypeptidase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008758">
        <property type="entry name" value="Peptidase_S28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11010">
        <property type="entry name" value="PROTEASE S28 PRO-X CARBOXYPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11010:SF117">
        <property type="entry name" value="SERINE PROTEASE 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05577">
        <property type="entry name" value="Peptidase_S28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012814031" evidence="6">
        <location>
            <begin position="16"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAG02345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="547" mass="61342" checksum="8DB215D86B5BB401" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C4G7</accession>
    <name>A0A177C4G7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Conserved oligomeric Golgi complex subunit 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">CC84DRAFT_1166468</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG02634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032999.1">
        <property type="nucleotide sequence ID" value="XM_018178967.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C4G7"/>
    <dbReference type="FunCoup" id="A0A177C4G7">
        <property type="interactions" value="37"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177C4G7"/>
    <dbReference type="GeneID" id="28762453"/>
    <dbReference type="InParanoid" id="A0A177C4G7"/>
    <dbReference type="OrthoDB" id="18786at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017119">
        <property type="term" value="C:Golgi transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019465">
        <property type="entry name" value="Cog5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048485">
        <property type="entry name" value="COG5_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049176">
        <property type="entry name" value="COG5_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13228">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX COMPONENT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13228:SF3">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20649">
        <property type="entry name" value="COG5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10392">
        <property type="entry name" value="COG5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Conserved oligomeric Golgi complex subunit 5 N-terminal" evidence="5">
        <location>
            <begin position="12"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="Conserved oligomeric Golgi complex subunit 5 helical" evidence="6">
        <location>
            <begin position="192"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF10392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF20649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="OAG02634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="450" mass="48729" checksum="DD6EEED3048BE5F1" modified="2016-09-07" version="1">MSDGEPSYIDYEEFLDPDFSATAFANTLVLSTNNPSDTPLDLSTPLSRVLFDVQDIDTQIDTLTTKSALPLLDYTREHAASSGRILEEVEGQVASLTESYKALEKEVIERHEVAEQVRLTAERLCQTVKMGRAVARCLMLGRQLEVRMTEIGGVGSAKKEDHRAMVRSADTLLSLRQMFAASGPGEEGEGLDRVNVVNALKNELVSPGERSITSRAQQVVKEFSMSSLLTSGGQASSSTFTQTEDTKSRTTSALLTLYLLSPAAANGAAFSPTLLLSALRDYLETQLKSSLASLARSLATLPTLDRTLLEISARCQNILALEMLLESTKPPAHPLLQPIVNEPSHPDKAPPNNFLQPLLHALDTSSLPSYFWRSLASNLAPRVQDIMHRGGVSARTLRSNKDRVRDAVRDCVNRGSQVPGAPAGKGKAGAAGNWEREAAVMVSSISGQIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C4Y2</accession>
    <name>A0A177C4Y2_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Rhomboid-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CC84DRAFT_1150497</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S54 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG02575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032940.1">
        <property type="nucleotide sequence ID" value="XM_018176708.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C4Y2"/>
    <dbReference type="FunCoup" id="A0A177C4Y2">
        <property type="interactions" value="620"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177C4Y2"/>
    <dbReference type="GeneID" id="28760194"/>
    <dbReference type="InParanoid" id="A0A177C4Y2"/>
    <dbReference type="OrthoDB" id="418595at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022764">
        <property type="entry name" value="Peptidase_S54_rhomboid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050925">
        <property type="entry name" value="Rhomboid_protease_S54"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43731:SF14">
        <property type="entry name" value="PRESENILIN-ASSOCIATED RHOMBOID-LIKE PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43731">
        <property type="entry name" value="RHOMBOID PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01694">
        <property type="entry name" value="Rhomboid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="124"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="158"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="187"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="211"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="242"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S54 rhomboid" evidence="8">
        <location>
            <begin position="115"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAG02575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="267" mass="29459" checksum="640F718FA2FA0399" modified="2016-09-07" version="1">MSLFQRLTRTLRPTSFGAISTLRATRSARSPELGSNFFGNATRLGLRHRTYKAYNAPEDHTTSNMRLIYAFMGLNGAIFAYATYVQEQAKQGYTPAFIHFLQNCTLSPTGFFKEGRYWTTITSVFSHMNIMHIAGNMLSFFFMGQMLATTPGFTPGKIAVLVIGSGLAGSIGWLYTTMKNRNYQKRALGFSGSVMGVGTVAAFLYPKAQFAIYGIVPVPLWALIAGYAVYDGYYLDDSNSKVGHAGHLGGLAFGIVYYFARVRGLRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2023-06-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C5D7</accession>
    <name>A0A177C5D7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">CC84DRAFT_983054</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441556">
        <property type="protein sequence ID" value="OAG02102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032467.1">
        <property type="nucleotide sequence ID" value="XM_018188050.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C5D7"/>
    <dbReference type="GeneID" id="28771536"/>
    <dbReference type="InParanoid" id="A0A177C5D7"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="OAG02102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="118" mass="13724" checksum="1BC0CD6E352710ED" modified="2016-09-07" version="1">MQSVCGVFARCHSPRVWSAEFTPAFINRYPANGFRGHLGLRLCRISNAKRRSRIRCWRFDISVPGCIGAAWRVLVVVYRVPRPHVSESWSHRASFNHRNNRPGWDDNWAPHLLINKCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C5L0</accession>
    <name>A0A177C5L0_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidase C14</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1167294</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C14B family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441556">
        <property type="protein sequence ID" value="OAG02172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032537.1">
        <property type="nucleotide sequence ID" value="XM_018179147.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C5L0"/>
    <dbReference type="GeneID" id="28762633"/>
    <dbReference type="InParanoid" id="A0A177C5L0"/>
    <dbReference type="OrthoDB" id="3223806at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12660">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050452">
        <property type="entry name" value="Metacaspase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011600">
        <property type="entry name" value="Pept_C14_caspase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48104:SF30">
        <property type="entry name" value="METACASPASE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48104">
        <property type="entry name" value="METACASPASE-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00656">
        <property type="entry name" value="Peptidase_C14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase C14 caspase" evidence="2">
        <location>
            <begin position="4"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG02172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="318" mass="34910" checksum="A6C6472A5452E7A9" modified="2016-09-07" version="1">MAQRKKSLLIGINYVGSKHELKGCHSDVDNIAEFLSYRGYSNSHRDRVILSDNPVVAPDSPYYPTGHNILAAMDWLVSEPGCTLFMHYSGHGGQVEDVDSNRSTGLDDSLVPVDFEYNGQLSSTLLHQHLVTRMAPGCTLFVLMDCCHSGSAIELPFVYRTDADGQISLMDNLRKGAQLVGEAQDILSGGFNFNKMGEARELFAGATSFFHGLKHMGEQEEEGLQEGEFVGQYGSENKMVTMFSGCRDDQTSADANIAGRSTGAMTWAFLQIMKAGETPTYARTLQMTRQLLDQSNYTQVPQLSSGLDIDLDNLPLAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C5N5</accession>
    <name>A0A177C5N5_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_1167186</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441556">
        <property type="protein sequence ID" value="OAG02037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032402.1">
        <property type="nucleotide sequence ID" value="XM_018179133.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C5N5"/>
    <dbReference type="FunCoup" id="A0A177C5N5">
        <property type="interactions" value="283"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177C5N5"/>
    <dbReference type="GeneID" id="28762619"/>
    <dbReference type="InParanoid" id="A0A177C5N5"/>
    <dbReference type="OrthoDB" id="2262349at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009074">
        <property type="term" value="P:aromatic amino acid family catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.240.10:FF:000012">
        <property type="entry name" value="C6 transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052780">
        <property type="entry name" value="AAA_Catabolism_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31644">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR ARO80-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31644:SF2">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR ARO80-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="26"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="63"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="180"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="825"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="869"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="932"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="107"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="138"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="186"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="932"/>
            <end position="952"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAG02037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="1011" mass="110868" checksum="FC3313D9682A69D1" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C5P7</accession>
    <name>A0A177C5P7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">rhamnogalacturonan endolyase</fullName>
            <ecNumber evidence="4">4.2.2.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">CC84DRAFT_1152216</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endotype eliminative cleavage of L-alpha-rhamnopyranosyl-(1-&gt;4)-alpha-D-galactopyranosyluronic acid bonds of rhamnogalacturonan I domains in ramified hairy regions of pectin leaving L-rhamnopyranose at the reducing end and 4-deoxy-4,5-unsaturated D-galactopyranosyluronic acid at the non-reducing end.</text>
            <dbReference type="EC" id="4.2.2.23"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the polysaccharide lyase 4 family.</text>
    </comment>
    <dbReference type="EC" id="4.2.2.23" evidence="4"/>
    <dbReference type="EMBL" id="KV441556">
        <property type="protein sequence ID" value="OAG02047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032412.1">
        <property type="nucleotide sequence ID" value="XM_018176792.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C5P7"/>
    <dbReference type="GeneID" id="28760278"/>
    <dbReference type="InParanoid" id="A0A177C5P7"/>
    <dbReference type="OrthoDB" id="1179585at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102210">
        <property type="term" value="F:rhamnogalacturonan endolyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd10316">
        <property type="entry name" value="RGL4_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10320">
        <property type="entry name" value="RGL4_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1120">
        <property type="entry name" value="Carboxypeptidase-like, regulatory domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013784">
        <property type="entry name" value="Carb-bd-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051850">
        <property type="entry name" value="Polysacch_Lyase_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029413">
        <property type="entry name" value="RG-lyase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029411">
        <property type="entry name" value="RG-lyase_III"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32018:SF1">
        <property type="entry name" value="RHAMNOGALACTURONAN ENDOLYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32018">
        <property type="entry name" value="RHAMNOGALACTURONATE LYASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14683">
        <property type="entry name" value="CBM-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14686">
        <property type="entry name" value="fn3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49452">
        <property type="entry name" value="Starch-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7 13" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008057748" description="rhamnogalacturonan endolyase" evidence="10">
        <location>
            <begin position="19"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="domain" description="Rhamnogalacturonan lyase" evidence="12">
        <location>
            <begin position="314"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="Rhamnogalacturonan lyase" evidence="11">
        <location>
            <begin position="410"/>
            <end position="570"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF14683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF14686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="OAG02047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="573" mass="63710" checksum="C688E352F377D982" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C5U7</accession>
    <name>A0A177C5U7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">WD40 repeat-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_1178383</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the WD repeat cdt2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG02796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033161.1">
        <property type="nucleotide sequence ID" value="XM_018180338.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C5U7"/>
    <dbReference type="STRING" id="1460663.A0A177C5U7"/>
    <dbReference type="GeneID" id="28763824"/>
    <dbReference type="InParanoid" id="A0A177C5U7"/>
    <dbReference type="OrthoDB" id="2096344at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051865">
        <property type="entry name" value="WD-repeat_CDT2_adapter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22852:SF0">
        <property type="entry name" value="DENTICLELESS PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22852">
        <property type="entry name" value="LETHAL 2 DENTICLELESS PROTEIN RETINOIC ACID-REGULATED NUCLEAR MATRIX-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="2 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="257"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="299"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="610"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="982"/>
            <end position="1001"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="50"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="115"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="982"/>
            <end position="991"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAG02796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="1146" mass="127433" checksum="513F04857184C44B" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C5U8</accession>
    <name>A0A177C5U8_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_1099031</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KV441556">
        <property type="protein sequence ID" value="OAG02060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018032425.1">
        <property type="nucleotide sequence ID" value="XM_018174798.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C5U8"/>
    <dbReference type="GeneID" id="28758284"/>
    <dbReference type="InParanoid" id="A0A177C5U8"/>
    <dbReference type="OrthoDB" id="4139357at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010573">
        <property type="entry name" value="MFS_Str1/Tri12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF195">
        <property type="entry name" value="PEP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06609">
        <property type="entry name" value="TRI12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="49"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="87"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="204"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="244"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="274"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="315"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="356"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="386"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="409"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="497"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="534"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="49"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAG02060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="582" mass="62317" checksum="309CBC02BEAEBD09" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C711</accession>
    <name>A0A177C711_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Prokaryotic-type class I peptide chain release factors domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1166491</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG02659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033024.1">
        <property type="nucleotide sequence ID" value="XM_018178973.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C711"/>
    <dbReference type="FunCoup" id="A0A177C711">
        <property type="interactions" value="247"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177C711"/>
    <dbReference type="GeneID" id="28762459"/>
    <dbReference type="InParanoid" id="A0A177C711"/>
    <dbReference type="OrthoDB" id="270639at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004045">
        <property type="term" value="F:peptidyl-tRNA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016150">
        <property type="term" value="F:translation release factor activity, codon nonspecific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070126">
        <property type="term" value="P:mitochondrial translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052104">
        <property type="entry name" value="Mito_Release_Factor_mL62"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000352">
        <property type="entry name" value="Pep_chain_release_fac_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11075:SF54">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11075">
        <property type="entry name" value="PEPTIDE CHAIN RELEASE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00472">
        <property type="entry name" value="RF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110916">
        <property type="entry name" value="Peptidyl-tRNA hydrolase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prokaryotic-type class I peptide chain release factors" evidence="2">
        <location>
            <begin position="56"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG02659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="193" mass="21364" checksum="30272B95DA1FF451" modified="2016-09-07" version="1">MLRARFPAARRSLTARPLLPVAPLVRFASDRSTSDASPEELQAARRWLAQLHAETIPKSIGELSFSRSSGPGGQNVNKVNSKATLKMPLNALLDHVPSVLHHEIRASRYVAERSSAIVIQADDSRKQNDNAHSCYKRLYEAIVEAGHAAIPGETSAEQAKRVKDLQKSDNERRIKTKKQHSAKKSSRRGRGDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C8D7</accession>
    <name>A0A177C8D7_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Clavaminate synthase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_1251210</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG03119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033484.1">
        <property type="nucleotide sequence ID" value="XM_018184324.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C8D7"/>
    <dbReference type="STRING" id="1460663.A0A177C8D7"/>
    <dbReference type="GeneID" id="28767810"/>
    <dbReference type="InParanoid" id="A0A177C8D7"/>
    <dbReference type="OrthoDB" id="288590at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050231">
        <property type="entry name" value="Iron_ascorbate_oxido_reductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47990">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Non-haem dioxygenase N-terminal" evidence="3">
        <location>
            <begin position="33"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="438"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="8"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAG03119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="461" mass="51536" checksum="963ACB30F3857B01" modified="2016-09-07" version="1">MPHSERTASPPADASAALPSFPDNVPTAPLLRISLAKLLRNDADEYERCWRACCELGFFYVDLQTEDGTGEALLEEVGQLFEVMKDFFGLPVEEKTKYDFADQGSYFGYKGYGKGIVDGKGTRDRNEFYNISKDDILNLSPPLPCPDLLNPHRPLFESYIRASHNLCMLFASLVSSRLSLNPQTRASGGLSALHDLSAQSGDQIRFVKAPPQPHSSAAVALGEHTDFGKYTLSLLRDDSIQPSRRTPSAPPTVHRANAAFIVCAVLGCRKGALPGRVDFSGGRLRSNIHRVVPPPGEQWQVDRYSLVYFCRPVNDVVLKTLVEGEELGEEEEVSAKEWILRRALGRRREDGWKESAGTEGKYGIDIWSRAPSLKGTCENYFETLSIRQGLHFLEEVRYKQGLGRWNLLEIMFGRGSRNDLETPPPLSCSLPHHLDLRPRSHFSGPERRPTRHVEASRVVSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C8N7</accession>
    <name>A0A177C8N7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">FAD-binding FR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">CC84DRAFT_1178604</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441555">
        <property type="protein sequence ID" value="OAG03070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033435.1">
        <property type="nucleotide sequence ID" value="XM_018180359.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C8N7"/>
    <dbReference type="STRING" id="1460663.A0A177C8N7"/>
    <dbReference type="GeneID" id="28763845"/>
    <dbReference type="InParanoid" id="A0A177C8N7"/>
    <dbReference type="OrthoDB" id="1856718at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030586">
        <property type="term" value="F:[methionine synthase] reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050667">
        <property type="term" value="P:homocysteine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000027">
        <property type="entry name" value="FAD binding domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.990.10:FF:000007">
        <property type="entry name" value="Methionine synthase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.990.10">
        <property type="entry name" value="NADPH-cytochrome p450 Reductase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003097">
        <property type="entry name" value="CysJ-like_FAD-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023173">
        <property type="entry name" value="NADPH_Cyt_P450_Rdtase_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384:SF84">
        <property type="entry name" value="METHIONINE SYNTHASE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384">
        <property type="entry name" value="NITRIC OXIDE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00667">
        <property type="entry name" value="FAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="7">
        <location>
            <begin position="219"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="32"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="OAG03070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="647" mass="71471" checksum="98CD639C5331B2D6" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177C9I0</accession>
    <name>A0A177C9I0_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1165626</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG03380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018033745.1">
        <property type="nucleotide sequence ID" value="XM_018178764.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177C9I0"/>
    <dbReference type="GeneID" id="28762250"/>
    <dbReference type="InParanoid" id="A0A177C9I0"/>
    <dbReference type="OrthoDB" id="5363290at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42083">
        <property type="entry name" value="MARVEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42083:SF1">
        <property type="entry name" value="MARVEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="131"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG03380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="187" mass="20985" checksum="EBA1C66BF2851053" modified="2016-09-07" version="1">MAAPKSTFRSAVHTRLDKPLVSLFRVIQFAFALGSGISYAIELSHEHTSSEFIFAQLEFAITIITQIIDAFTLRSYRLTFLVESTICVLWLALFGVFYQIYPNGEELQSQYDDMTLGRAKTAVWLDLINSLLWLGSAVFSTVMCCAGTNGAIKWNLEQSRGKNSRKDREGAAEMESGVFHERPQGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CAC1</accession>
    <name>A0A177CAC1_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Peptidase M43 pregnancy-associated plasma-A domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">CC84DRAFT_1164973</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M43B family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG04525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034890.1">
        <property type="nucleotide sequence ID" value="XM_018178613.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CAC1"/>
    <dbReference type="STRING" id="1460663.A0A177CAC1"/>
    <dbReference type="GeneID" id="28762099"/>
    <dbReference type="InParanoid" id="A0A177CAC1"/>
    <dbReference type="OrthoDB" id="536211at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008754">
        <property type="entry name" value="Peptidase_M43"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47466">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47466:SF1">
        <property type="entry name" value="METALLOPROTEASE MEP1 (AFU_ORTHOLOGUE AFUA_1G07730)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05572">
        <property type="entry name" value="Peptidase_M43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M43 pregnancy-associated plasma-A" evidence="9">
        <location>
            <begin position="21"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="OAG04525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="163" mass="17267" checksum="5E320D74A555DDAD" modified="2016-09-07" version="1">MRTLHQGDYQTLNIYLVEGAGGGVCSFPDGSGQPISQDLLDFDGCFVPLEAGRSATSGTLAHEIGHWFGLLHTFQGGCDGDGDYCDDTAPQNEPSHGALATPGDLGSCPAADQCGKGPANVKNFMDYTDCSQEFTPCQGGRMNVAWSQYRVGRALAEGVQVKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CAS7</accession>
    <name>A0A177CAS7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">EthD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1121465</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the tpcK family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG04783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035148.1">
        <property type="nucleotide sequence ID" value="XM_018175612.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CAS7"/>
    <dbReference type="STRING" id="1460663.A0A177CAS7"/>
    <dbReference type="GeneID" id="28759098"/>
    <dbReference type="InParanoid" id="A0A177CAS7"/>
    <dbReference type="OrthoDB" id="3183782at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009799">
        <property type="entry name" value="EthD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07110">
        <property type="entry name" value="EthD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EthD" evidence="2">
        <location>
            <begin position="19"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG04783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="165" mass="18373" checksum="4A95FC20EE1E22A4" modified="2016-09-07" version="1">MAPQKETLLKFTSRRYKSPSVSEEAFHAFATSDHAPKAAPIQARHGFLGVRQSFKPTALRALLTEGPFAANKPPGWTVDDHDFEIVFYVRSMEQLGGLLGDPDFQQLMADEADICDQERAELSIGWEEVFVENGKVVNIEEGKSVYQGWNESVEKLAGKKEGSKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CAY0</accession>
    <name>A0A177CAY0_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF8035 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">CC84DRAFT_1166136</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG03999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034364.1">
        <property type="nucleotide sequence ID" value="XM_018178882.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CAY0"/>
    <dbReference type="STRING" id="1460663.A0A177CAY0"/>
    <dbReference type="GeneID" id="28762368"/>
    <dbReference type="InParanoid" id="A0A177CAY0"/>
    <dbReference type="OrthoDB" id="2192830at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058348">
        <property type="entry name" value="DUF8035"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26118">
        <property type="entry name" value="DUF8035"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF8035" evidence="2">
        <location>
            <begin position="262"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="234"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="OAG03999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="473" mass="56999" checksum="A992E0D015ABD7B7" modified="2016-09-07" version="1">MYRSSTGTLDHYDDAPRGGERWDRDRFERMARRAPPPRDVKDDFHFHEHDRFPGGRRDMDIREDYERRAPPPPTRVMEREREREVFREDDRFDRRRRHDLFDEPTPSQIANQALAPYRRKSVVDRDFEVDIHREQTKRPARPQYIRRQSSLDTFDRRPLPRYGDRERDEWRPPANVPIPLPIRERRRSPQRYQEEEFEEERFMERDRPGRREKVEEYREVEVHRAKSRRRRSPSRSVARSQARSSSTSSFEEIKLARADWGKKGKTRLPKRLCRVQAVTELGYPYEEEEDFIVITRALEKDHIDEIISVSEKYKETKTTYVYEDTRSVVEQPPAMMAPPPPPPPPMMDYPPPPPPPASVHGNTVVYERSVRGASPPRSHHHEHYEERIEESNHIGGPLTVLVPEERRVVRRERDVRSEREIREEIRMLEDERRMLKYERDGDYEIIERREKPREVIRIEKDRKGRMALVRSAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CAZ5</accession>
    <name>A0A177CAZ5_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MOSC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">CC84DRAFT_1197504</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG03947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034312.1">
        <property type="nucleotide sequence ID" value="XM_018181525.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CAZ5"/>
    <dbReference type="STRING" id="1460663.A0A177CAZ5"/>
    <dbReference type="GeneID" id="28765011"/>
    <dbReference type="InParanoid" id="A0A177CAZ5"/>
    <dbReference type="OrthoDB" id="17255at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030151">
        <property type="term" value="F:molybdenum ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005302">
        <property type="entry name" value="MoCF_Sase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005303">
        <property type="entry name" value="MOCOS_middle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011037">
        <property type="entry name" value="Pyrv_Knase-like_insert_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03473">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03476">
        <property type="entry name" value="MOSC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50800">
        <property type="entry name" value="PK beta-barrel domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51340">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MOSC" evidence="1">
        <location>
            <begin position="292"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="OAG03947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="447" mass="49492" checksum="C73D66E7920C4D1D" modified="2016-09-07" version="1">MASPNALDFLLSSIEKTWHDVGVRATPLALLTTSLALLLPIISLYLLALSQREQPTPPPAGCRKLNKSGTSNLSDQFAKKYDHGGEPSASNAWKVKALMVYPLKSCGGVELEKAEVGHTGLKYDRQFTFAQQVTSLPTLEGKVKSEWTFITLRQFPRLAKVEVEMWVPDPKAPGYHKDGEWVKSDGCIVARFPFSPDTEFSVAGIKNYGKILAAKLGGRSEPMVEFRIPFDPKKDIIAARGYRKEPVKIFDDVPVALNVGCDLSDEIVDQLKYTLGVSNPLTIFRIDPDSPRLVLQNAPKKEDVGFQTAIGMQDAHPVQIQNLASIHDVSSRVPSRFRPLNALRYRPNIIFTGPPAFEEDEWKKARFGSLTLDISCRTTRCKLPNVDPLTGIADRNEPGTTMRKYRVVDKGSKAACLGMQVTPLDEGILIVGDEIKVLATGEHYFIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CBB4</accession>
    <name>A0A177CBB4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein ARV</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">CC84DRAFT_1062649</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Mediator of sterol homeostasis involved in sterol uptake, trafficking and distribution into membranes.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Regulates also the sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Endoplasmic reticulum membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Golgi apparatus membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the ARV1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG04000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034365.1">
        <property type="nucleotide sequence ID" value="XM_018173599.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CBB4"/>
    <dbReference type="FunCoup" id="A0A177CBB4">
        <property type="interactions" value="24"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CBB4"/>
    <dbReference type="GeneID" id="28757085"/>
    <dbReference type="InParanoid" id="A0A177CBB4"/>
    <dbReference type="OrthoDB" id="2192830at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032541">
        <property type="term" value="C:cortical endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032366">
        <property type="term" value="P:intracellular sterol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097036">
        <property type="term" value="P:regulation of plasma membrane sterol distribution"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006665">
        <property type="term" value="P:sphingolipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016125">
        <property type="term" value="P:sterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007290">
        <property type="entry name" value="Arv1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14467">
        <property type="entry name" value="ARV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14467:SF0">
        <property type="entry name" value="PROTEIN ARV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04161">
        <property type="entry name" value="Arv1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7 10" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="148"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="222"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU368065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="OAG04000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="277" mass="30384" checksum="3A44532E9CF2DEFB" modified="2016-09-07" version="1" fragment="single">MPICIECRAPVKTLYTSYSKADDRALGKGVRLTQCPRCKRFADKYIEHDFVVIFLDLVLIKPQVYRHLLFNKLGLEDDRFDVIEWQRSILRLGTLLLLFDVYLTWARIEKASFPLPAPPPSPSINITNTAPPPLPPSTIPTLPLILQYLFYLTLVLLSTLSFHLPIRLLCSIPPTSLPSPLRFLLASAYFPAGNALSTALLVSSCTKLFPILLIIWEYDLPSAAAAVGWAVAVNNVAAVEILVGCGWLRAGMLVGIGAACREVVSRAVLGAVGLSEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CBH4</accession>
    <name>A0A177CBH4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidase A1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">CC84DRAFT_1260019</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG04686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035051.1">
        <property type="nucleotide sequence ID" value="XM_018184959.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CBH4"/>
    <dbReference type="GeneID" id="28768445"/>
    <dbReference type="InParanoid" id="A0A177CBH4"/>
    <dbReference type="OrthoDB" id="5361565at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008057965" description="Peptidase A1 domain-containing protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="414"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="3">
        <location>
            <begin position="45"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="OAG04686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="488" mass="53552" checksum="E066796924FB5173" modified="2016-09-07" version="1">MVSLAFYLSATVLLAQSSVAFNCSIPPIYVDIHKRVTHNTDNFQYGSFIGIGTPAQNHSLWPSLSRNQTSFGASTFCDGNSTLKDCKESTGGFFNSRDSTTFIEDKDYQTLDTAPNSTIKESFYGYDSLRLYTHYFETDGAWQTLVDNSSVEVVEEGTAKPAVVGLGTSSTILNDLAARNQICGKMYSLYIGQGFDRAGGAVNGSNVFGGYDAGRFIDPVHKYSMGSAGENHLNVRVKDIIISETNNVNANVSLFDTAAFPSMSSRPDTFDAQITTDQYPLSLPYEITQNFISHLQAEEDNTWGDNSLKLKNAFNGSMTIILDDGFEVTIPPSVLMNASNITPVQSRAKDSNEPFYLSTAFLTQVYLMADFEKQSFFLATAVQKNNMVMPTPFCPGSTPTAYQRPNQGAFVKQGLIGAIVGGVLGGIGIGICAYCFIASCRRRVAERRIEKRAEEGRKAAKMAQFEVEEVTEFDPPPKSATPFFWKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CBR4</accession>
    <name>A0A177CBR4_9PLEO</name>
    <protein>
        <submittedName>
            <fullName evidence="15">p-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">CC84DRAFT_1247813</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG05133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035498.1">
        <property type="nucleotide sequence ID" value="XM_018184241.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CBR4"/>
    <dbReference type="STRING" id="1460663.A0A177CBR4"/>
    <dbReference type="GeneID" id="28767727"/>
    <dbReference type="InParanoid" id="A0A177CBR4"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015421">
        <property type="term" value="F:ABC-type oligopeptide transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090374">
        <property type="term" value="P:oligopeptide export from mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18577">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18578">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03249">
        <property type="entry name" value="ABC_MTABC3_MDL1_MDL2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000102">
        <property type="entry name" value="ABC multidrug transporter Mdr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000913">
        <property type="entry name" value="ABC multidrug transporter SitT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000009">
        <property type="entry name" value="ABC transporter B family member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000251">
        <property type="entry name" value="ABC transporter B family member 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394:SF11">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394">
        <property type="entry name" value="ATP-DEPENDENT PERMEASE MDL1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="50"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="104"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="206"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="287"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="318"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="751"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="830"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="854"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="937"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="968"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="14">
        <location>
            <begin position="57"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="13">
        <location>
            <begin position="384"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="14">
        <location>
            <begin position="710"/>
            <end position="997"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="13">
        <location>
            <begin position="1032"/>
            <end position="1270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="650"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="672"/>
            <end position="682"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="OAG05133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="1276" mass="138560" checksum="6167E653F6508A42" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CBU0</accession>
    <name>A0A177CBU0_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRM61</fullName>
            <ecNumber evidence="2">2.1.1.220</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">tRNA(m1A58)-methyltransferase subunit TRM61</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">CC84DRAFT_1165172</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.1.1.220" evidence="2"/>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG04796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035161.1">
        <property type="nucleotide sequence ID" value="XM_018178657.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CBU0"/>
    <dbReference type="FunCoup" id="A0A177CBU0">
        <property type="interactions" value="637"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CBU0"/>
    <dbReference type="GeneID" id="28762143"/>
    <dbReference type="InParanoid" id="A0A177CBU0"/>
    <dbReference type="OrthoDB" id="1925287at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031515">
        <property type="term" value="C:tRNA (m1A) methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160107">
        <property type="term" value="F:tRNA (adenine(58)-N1)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.330.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049470">
        <property type="entry name" value="TRM61_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014816">
        <property type="entry name" value="tRNA_MeTrfase_Gcd14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12133">
        <property type="entry name" value="TRNA (ADENINE(58)-N(1))-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12133:SF2">
        <property type="entry name" value="TRNA (ADENINE(58)-N(1))-METHYLTRANSFERASE CATALYTIC SUBUNIT TRMT61A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08704">
        <property type="entry name" value="GCD14"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51620">
        <property type="entry name" value="SAM_TRM61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRM61 C-terminal" evidence="11">
        <location>
            <begin position="121"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRM61 C-terminal" evidence="11">
        <location>
            <begin position="205"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRM61 C-terminal" evidence="11">
        <location>
            <begin position="331"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="77"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="189"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="291"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="417"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="206"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="300"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="417"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="443"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00033309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="OAG04796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="515" mass="56933" checksum="FACAADE1B248E705" modified="2016-09-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CBU7</accession>
    <name>A0A177CBU7_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Matrin-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">CC84DRAFT_800118</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SF3A3 family.</text>
    </comment>
    <dbReference type="EMBL" id="KV441553">
        <property type="protein sequence ID" value="OAG04661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018035026.1">
        <property type="nucleotide sequence ID" value="XM_018187458.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CBU7"/>
    <dbReference type="FunCoup" id="A0A177CBU7">
        <property type="interactions" value="1203"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CBU7"/>
    <dbReference type="GeneID" id="28770944"/>
    <dbReference type="InParanoid" id="A0A177CBU7"/>
    <dbReference type="OrthoDB" id="2160351at2759"/>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000690">
        <property type="entry name" value="Matrin/U1-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051421">
        <property type="entry name" value="RNA_Proc_DNA_Dmg_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031774">
        <property type="entry name" value="SF3A3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024598">
        <property type="entry name" value="SF3a60/Prp9_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022755">
        <property type="entry name" value="Znf_C2H2_jaz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12786:SF2">
        <property type="entry name" value="SPLICING FACTOR 3A SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12786">
        <property type="entry name" value="SPLICING FACTOR SF3A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16837">
        <property type="entry name" value="SF3A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11931">
        <property type="entry name" value="SF3a60_Prp9_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12171">
        <property type="entry name" value="zf-C2H2_jaz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50171">
        <property type="entry name" value="ZF_MATRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Matrin-type" evidence="8">
        <location>
            <begin position="404"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="334"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="334"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="363"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="OAG04661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000077069"/>
        </source>
    </evidence>
    <sequence length="499" mass="57782" checksum="397BCE8D085AA029" modified="2016-09-07" version="1">MLLEDQRNIHEELERLEDAIADRLLEDPPHIRDRLARDHDVAQFLRQIEERSGRLMSIYQDADGKLDDEVRNLTLGDPMESFAREVSNIKAYHSKYTNMPVENLEKAYKRRSPEDHAHSIATIDSMFTGEEGFGRFFDLTTLHEQYLNLPVQQQARRLTYLQYLDVFDVFTPPQATIRRDQKMSESYFQYLKALQEYLESFMRRTKPLENLDKLFANFDKEFEEKWADDQIPGWEKNPTQASQAAGDAMEEGIYCSACKKGFAKESVYEAHLTGKKHKKAAAELESSTTVATTNGPGGDMNRFKERAVAEREFRIRRLAAAMQTERGDTKVNVERKQGMTERERQQELEQLYSEAPETANGGNDEDDDEDGEDKIYNPLKLPLAWDGKPIPFWLYKLHGLGVEFPCEICGNYVWMGRRAFDKHFNEPRHIHGLRCLGITNTTLFREITSIDEAQTLWRKIQQDKKKEKATVDNVVQMEDSEGNVMPEKVYKDLAAQGLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-09-07" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A177CBV4</accession>
    <name>A0A177CBV4_9PLEO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 18">3-isopropylmalate dehydratase</fullName>
            <ecNumber evidence="6 18">4.2.1.33</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16 18">Alpha-IPM isomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17 18">Isopropylmalate isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">CC84DRAFT_1124115</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Paraphaeosphaeria sporulosa</name>
        <dbReference type="NCBI Taxonomy" id="1460663"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Dothideomycetes</taxon>
            <taxon>Pleosporomycetidae</taxon>
            <taxon>Pleosporales</taxon>
            <taxon>Massarineae</taxon>
            <taxon>Didymosphaeriaceae</taxon>
            <taxon>Paraphaeosphaeria</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="submission" date="2016-05" db="EMBL/GenBank/DDBJ databases">
            <title>Comparative analysis of secretome profiles of manganese(II)-oxidizing ascomycete fungi.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Zeiner C.A."/>
                <person name="Purvine S.O."/>
                <person name="Zink E.M."/>
                <person name="Wu S."/>
                <person name="Pasa-Tolic L."/>
                <person name="Chaput D.L."/>
                <person name="Haridas S."/>
                <person name="Grigoriev I.V."/>
                <person name="Santelli C.M."/>
                <person name="Hansel C.M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">AP3s5-JAC2a</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 18">Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 18">
            <text>(2R,3S)-3-isopropylmalate = (2S)-2-isopropylmalate</text>
            <dbReference type="Rhea" id="RHEA:32287"/>
            <dbReference type="ChEBI" id="CHEBI:1178"/>
            <dbReference type="ChEBI" id="CHEBI:35121"/>
            <dbReference type="EC" id="4.2.1.33"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4 18">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 2/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 18">Belongs to the aconitase/IPM isomerase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.33" evidence="6 18"/>
    <dbReference type="EMBL" id="KV441554">
        <property type="protein sequence ID" value="OAG04238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_018034603.1">
        <property type="nucleotide sequence ID" value="XM_018175674.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A177CBV4"/>
    <dbReference type="FunCoup" id="A0A177CBV4">
        <property type="interactions" value="230"/>
    </dbReference>
    <dbReference type="STRING" id="1460663.A0A177CBV4"/>
    <dbReference type="GeneID" id="28759160"/>
    <dbReference type="InParanoid" id="A0A177CBV4"/>
    <dbReference type="OrthoDB" id="2279155at2759"/>
    <dbReference type="UniPathway" id="UPA00048">
        <property type="reaction ID" value="UER00071"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000077069">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009316">
        <property type="term" value="C:3-isopropylmalate dehydratase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003861">
        <property type="term" value="F:3-isopropylmalate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:L-leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01583">
        <property type="entry name" value="IPMI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01577">
        <property type="entry name" value="IPMI_Swivel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.499.10:FF:000006">
        <property type="entry name" value="3-isopropylmalate dehydratase large subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.499.10:FF:000007">
        <property type="entry name" value="3-isopropylmalate dehydratase large subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.19.10:FF:000003">
        <property type="entry name" value="3-isopropylmalate dehydratase small subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.499.10">
        <property type="entry name" value="Aconitase, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.19.10">
        <property type="entry name" value="Aconitase, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01026">
        <property type="entry name" value="LeuC_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01031">
        <property type="entry name" value="LeuD_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004430">
        <property type="entry name" value="3-IsopropMal_deHydase_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004431">
        <property type="entry name" value="3-IsopropMal_deHydase_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012235">
        <property type="entry name" value="3-IsopropMal_deHydtase_ssu/lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015931">
        <property type="entry name" value="Acnase/IPM_dHydase_lsu_aba_1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001030">
        <property type="entry name" value="Acoase/IPM_deHydtase_lsu_aba"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015928">
        <property type="entry name" value="Aconitase/3IPM_dehydase_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018136">
        <property type="entry name" value="Aconitase_4Fe-4S_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036008">
        <property type="entry name" value="Aconitase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000573">
        <property type="entry name" value="AconitaseA/IPMdHydase_ssu_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050067">
        <property type="entry name" value="IPM_dehydratase_rel_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033941">
        <property type="entry name" value="IPMI_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033940">
        <property type="entry name" value="IPMI_Swivel"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00170">
        <property type="entry name" value="leuC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00171">
        <property type="entry name" value="leuD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002458">
        <property type="entry name" value="PRK01641.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004016">
        <property type="entry name" value="PRK05478.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009116">
        <property type="entry name" value="PRK12466.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43822:SF9">
        <property type="entry name" value="3-ISOPROPYLMALATE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43822">
        <property type="entry name" value="HOMOACONITASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00330">
        <property type="entry name" value="Aconitase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00694">
        <property type="entry name" value="Aconitase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001418">
        <property type="entry name" value="ACN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00415">
        <property type="entry name" value="ACONITASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53732">
        <property type="entry name" value="Aconitase iron-sulfur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52016">
        <property type="entry name" value="LeuD/IlvD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00450">
        <property type="entry name" value="ACONITASE_1"/>
        <property type="match status